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Sample records for albinos tratados con

  1. Conversazioni autobiografiche con Albino Sacco-Casamassima

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    Orazio Maria Valastro

    2004-03-01

    Full Text Available Nel 1948 venne Olivetti a Matera. Olivetti venne a Matera con un certo ambasciatore americano che praticamente aveva preparato o stava dando una mano per il piano Marschall, venne a Matera e mi vollero incontrare. Io sono stato chiamato dalla piazza, stavo nella piazza, era il mese di luglio, una cosa di questo genere, e andai in un bar, un bar ad angolo mi ricordo in Via Don Minzioni, dove questo Olivetti mi disse 'ma lei che cosa fa coi sassi?' 'Che cos'è questa storia?' Gli raccontai un po' che cosa facevo io con questi amici, avevamo fatto questo, insomma tutto quello che avevamo fatto nei sassi e che volevamo preparare ancora per presentare a qualcuno un piano di revisionamento dei sassi. Mi ricordo, era la prima volta che avevo visto Adriano Olivetti, ne avevo sentito parlare però non avevo mai visto quest'uomo con gli occhi celesti, minuto, coi capelli bianchi, riccioluto, con una cravatta bianca, cosa che mi fece impressione, una specie di angelo.

  2. Análisis químico del esmalte dental humano tratado con una sustancia remineralizante experimental

    OpenAIRE

    González García, Jennifer

    2015-01-01

    El objetivo de este trabajó fue analizar químicamente el efecto de la aplicación de una sustancia remineralizante experimental (SRM) sobre el esmalte dental humano. Se tomaron 40 molares humanos repartidos aleatoriamente en 4 grupos, cada uno de 10 especímenes. Grupo 1: grupo sin tratamiento, Grupo 2: grupo tratado con peróxido de hidrógeno al 35%, Grupo 3. Grupo tratado con la sustancia remineralizante experimental, Grupo 4: grupo tratado con peróxido de hidrógeno al 35% y después con la sus...

  3. CON EL TRATADO DE LIBRE COMERCIO PERDIMOS TOD@S

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    Mario Rodríguez

    2008-12-01

    Full Text Available Resumen El objetivo principal de este artículo es analizar la inserción de la economía guatemalteca al proceso del desarrollo global del sistema capitalista. El trabajo sustenta la idea de que la estructura productiva se fue configurando a partir de los procesos de ajuste estructural y que la misma tuvo un sesgo marcadamente neoliberal. Esto permitió generar una plataforma política y económica que facilito la imposición de un modelo dependiente con la instauración de un Acuerdo Comercial con Estados Unidos. Este mecanismo es la última fase de la implantación del modelo económico de acumulación, que permite una inserción del capital nacional al gran mercado capitalista mundial y reconfigura la estructura productiva agrícola del país adaptándola a las nuevas necesidades del capital global.   Abstract The Objective of this article is analyzing the insertion of the Guatemalan economy to process of world development of capitalist system. The work support the idea of the productive structure was forming to begin of structures adjustments process and had a slant markedly neoliberal. It allowed produce a politic platform and economic that made easy the imposition of a dependent model with the establishment of one trade agreement with United States. It mechanism is the last stage of the implantation of economic model of accumulation, that allow a insertion of national working capital to big world capitalist market and reforming the farming productive structure of Guatemala; adjustmenting the country to the new necessities of world working capital.

  4. Avances y perspectivas del aprovechamiento del tratado de libre comercio con Estados Unidos

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    Hernando José Gómez

    2013-08-01

    Full Text Available En este artículo se hace una revisión de las oportunidades y los retos de exportación frente al Tratado de Libre Comercio (TLC con Estados Unidos. Asimismo, se traza un análisis de las necesidades transversales de los sectores de la economía incluyendo temas sanitarios, fitosanitarios y de calidad. De igual manera, se destaca la importancia de robustecer la industria nacional en términos de competitividad del sector agrícola y ganadero, confecciones, servicios en salud, metalmecánica, agroindustria, entre otros, de la mano de acciones logísticas y estrategias de innovación para lograr la eficiencia y aprovechamiento del tratado bilateral.

  5. Melanoma "in situ" tratado con Imiquimod Melanoma in situ treated with Imiquimod

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    RE Achenbach

    Full Text Available Comunicamos un caso con dos melanomas "in situ", en un varón de 86 años, localizados en ambos lados de la cara con alto riesgo quirúrgico, quien fuera tratado con imiquimod al 5% una vez al día durante dos meses; los resultados hasta el momento, clínicos e histológicos han sido satisfactorios.A 86 years-old man with two melanomas "in situ" at both sides of his face, treated with imiquimod 5% are presented. The patient has a cardiovascular high risk due to isquemic heart disease, for that reason we start the treatment with imiquimod once a day for two months. The clinical and histological response was good and a follow up will be as long as we can.

  6. Cambios psicológicos en pacientes con espondiloartritis axial tratados con infliximab

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    Morlà Novell, Rosa M.

    2015-01-01

    Es conocido que los pacientes con enfermedades reumáticas presentan alteraciones psicológicas relacionadas con su enfermedad articular crónica. Algunos estudios reportan el beneficio de las terapias biológicas en las espondiloartritis (EsP), pero son pocos los datos acerca del impacto de los fármacos biológicos en los síntomas psicológicos. El objetivo del estudio fue el de analizar la influencia del tratamiento con un fármaco biológico anti-TNFα, infliximab (IFX), en los síntomas de ansi...

  7. Esquistossomose mansoni experimental: carga parasitária e distribuição de vermes adultos no sistema porta de ratos albinos tratados com Azatioprina

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    Carlos Alberto Moreira Campos

    1983-09-01

    Full Text Available Estudou-se o curso da infecção esquistossomótica experimental no rato albino, um hospedeiro singular para o Schistosoma mansoni, e quatro semanas após a infecção houve uma rápida diminuição na carga parasitária, fato esse denominado por alguns pesquisadores como ' fenômeno de autocura Contudo, após a administração de um imunossupressor - a Azatioprina - observou-se uma maior susceptibilidade dos ratos à infecção, com os animais apresentando um significativo retardamento no chamado "fenômeno de autocura A grande maioria dos vermes é recuperada nos vasos intra-hepáticos do sistema porta, sem que haja migração para as veias mesentéricas. Quando os ratos foram tratados com Azatioprina observou-se uma significativa localização mesentérica dos vermes adultos neste hospedeiro.The course of experimental Schistosoma mansoni infection in the albino rat, a singular host for schistosomes was studied. Four weeks after infection there was a decrease of worm burden, a sélf-cure phenomenon reported by other investigators. However, after administration of a immunosupressive drug - Azathioprine - an increase in susceptibility of rats to infection was observed, with the animals presenting a significant delay in the to period selfcure. The majority of worms were recovered from the intra-hepatic veins of the portal system, but there was no migration to mesenteric veins. When rats were treated with Azathioprine a significant mesenteric localization of schistosomes was observed in this host.

  8. Esquistossomose mansoni experimental: carga parasitária e distribuição de vermes adultos no sistema porta de ratos albinos tratados com Azatioprina

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    Carlos Alberto Moreira Campos

    1983-09-01

    Full Text Available Estudou-se o curso da infecção esquistossomótica experimental no rato albino, um hospedeiro singular para o Schistosoma mansoni, e quatro semanas após a infecção houve uma rápida diminuição na carga parasitária, fato esse denominado por alguns pesquisadores como ' fenômeno de autocura Contudo, após a administração de um imunossupressor - a Azatioprina - observou-se uma maior susceptibilidade dos ratos à infecção, com os animais apresentando um significativo retardamento no chamado "fenômeno de autocura A grande maioria dos vermes é recuperada nos vasos intra-hepáticos do sistema porta, sem que haja migração para as veias mesentéricas. Quando os ratos foram tratados com Azatioprina observou-se uma significativa localização mesentérica dos vermes adultos neste hospedeiro.

  9. Cambios en la vía aérea superior en pacientes adultos tratados con ortodoncia con exodoncias de 4 premolares

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    Riera Seguí, María

    2014-01-01

    El objetivo de este estudio fue investigar los cambios que se producen en las dimensiones de la vía aérea superior en pacientes tratados con o sin exodoncias utilizando mínimo y máximo anclaje. Se seleccionaron telerradiografías laterales de cráneo de 24 pacientes con Clase I, con discrepancia óseo-dentaria severa o con biprotrusión, y fueron divididos en tres grupos (cada uno de ellos formado por 3 hombres y 5 mujeres) según el tratamiento recibido: grupo 1- ocho pacientes tra...

  10. Estudio sobre la evolución de la atrofia retiniana en pacientes con coriorretinopatía serosa central tratados con terapia fotodinámica

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    Sierra Rodríguez, María Ángeles

    2015-01-01

    Estudio sobre la evolución de la atrofia retiniana en pacientes con coriorretinopatía serosa central tratados con terapia fotodinámica. Quermos demostrar la correlación entre la atrofia retiniana posterior al tratamiento de la coriorretinopatía serosa central (CSC) con terapia fotodinámica (TFD) con verteporfina y los distintos factores asociados: edad del paciente, tiempo transcurrido desde el diagnóstico, dosis de verteporfina empleada, número de sesiones necesarias para la completa reab...

  11. Análisis comparativo de morbilidad en grandes quemados tratados con sesiones de autoinjertos frente a cultivo de queratinocitos

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    M. Rubio-Yanchuck

    2015-09-01

    Full Text Available La cobertura rápida y eficaz de las lesiones es un factor limitante en el tratamiento de grandes quemados. Los autoinjertos siguen siendo el tratamiento de elección pero no están exentos de riesgos. El uso de sustitutos de piel cultivada (SPC puede llegar a reducir la morbilidad implícita en el uso de autoinjertos. El objetivo de este estudio es realizar un análisis comparativo de la morbilidad asociada al uso de queratinocitos y autoinjertos en pacientes tratados inicialmente con aloinjertos como cobertura temporal. Realizamos un análisis retrospectivo de morbilidad en 21 pacientes con una superficie corporal quemada (SCQ mayor o igual al 40% en el Hospital Universitario La Paz, Madrid (España entre 2011y 2015. Fueron divididos en 2 grupos según la cobertura definitiva utilizada: un primer grupo con sesiones de autoinjerto, y un segundo grupo con cultivos de queratinocitos y áreas menores de autoinjertos. Fueron 5 mujeres y 16 varones con media de edad de 40,38 años, SCQ del 60,43% y SCQ dérmico profunda-subdérmica del 59,05%. La media de cirugías necesarias en pacientes tratados con autoinjertos y SPC fue 5,36 y 6,7 respectivamente. La incidencia de sepsis fue 80 frente a 50%; el fracaso renal agudo del 63,6 frente al 50%; y de neumonía del 27.3 frente al 40%. Entre los pacientes que sobrevivieron la estancia media en Unidad de Cuidados Intensivos fue de 66,16 frente a 50,6 días, la estancia media hospitalaria fue de 75,6 frente a 63,3 días y la media del número de trasfusiones fue de 75,6 frente a 63.3. La complicación del lecho quirúrgico en el grupo de autoinjertos fue del 63% frente al 0% en los tratados con queratinocitos, y las necesidades medias de noradrenalina fueron de 0,1 frente a 0,03 µg/kg/min. Los pacientes con lecho quirúrgico complicado tuvieron unos requerimientos medios de noradrenalina de 0,117 frente a 0,044 en pacientes con lecho quirúrgico no complicado. Como conclusión, los pacientes tratados con

  12. Estudio prospectivo del funcionamiento cognitivo en pacientes de cáncer de colon tratados con quimioterapia

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    López Santiago, Sonia

    2011-01-01

    El objetivo de esta tesis es investigar los cambios en rendimiento cognitivo de pacientes de cáncer de colon tratados con quimioterapia adyuvante. El método ha sido el estudio longitudinal unifactorial de tres medidas (T1: antes de la quimioterapia, T2: al finalizar el tratamiento y T3 seis meses después de T2); se explora: memoria verbal, función ejecutiva y habilidad psicomotora y variables moduladoras (ansiedad, depresión, astenia y calidad de vida). Muestra: 77 participantes, 63% varones,...

  13. Protección frente a la tinción dentaria en dientes tratados con tetraciclinas al aplicar un antioxidante (ácido ascórbico)

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    Bermúdez Semprún, María Esther; Beltri Orta, Paola; Bartolomé Villar, Begoña

    2014-01-01

    En la presente investigación pretendemos optimizar los resultados, evitando la coloración coronal, en procedimientos odontológicos donde sea imprescindible el uso de tetraciclinas así como evaluar la disminución de las coloraciones coronales, al aplicar un antioxidante (Acido Ascórbico) en dientes tratados con tetraciclinas (Minociclina y Doxiciclina). En los dientes tratados con minociclina y doxiciclina observamos cambios en la coloración dentaria apreciables tanto en corona como en la raíz...

  14. SUSTANCIAS Y REACCIONES QUÍMICAS. TEMAS DEL CURSO DE INGRESO UNIVERSITARIO TRATADOS CON DIFERENTES RECURSOS

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    René O. Güemes

    2011-01-01

    Full Text Available En esta investigación se buscó detectar y comparar dificultades presentadas en la comprensión de los temas “Sustancias” y “Reacciones Químicas” en alumnos ingresantes a la Universidad Nacional del Litoral (Santa Fe, Argentina implementando dos estrategias didácticas diferentes durante el dictado del “Curso de Ingreso de Química”. Se trabajó con dos grupos de alumnos; uno de los grupos utilizó un libro de texto, mientras que el otro trabajó con material multimedia en un aula de informática. Ambos grupos fueron evaluados al inicio y final del curso con la misma evaluación de opciones múltiples. Pudo comprobarse que el grupo que trabajó con el material multimedia alcanzó una mayor comprensión de los conceptos abstractos.

  15. Toxicidad cutánea a corto plazo de pacientes con cáncer de mama tratados con radioterapia hipofraccionada

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    Rolando Loría-Ruiz

    2013-12-01

    Full Text Available Antecedentes: reportar la factibilidad y resultados de toxicidad cutánea en una cohorte de pacientes portadores de cáncer de mama, tratados con un esquema de hipofraccionamiento de radioterapia externa, con un manejo multidisciplinario. Métodos: utilizando un software SPSS v18, se realizó un análisis retrospectivo de 299 pacientes (6 H y 293 M, tratados entre marzo de 2009 y diciembre de 2011, en el Instituto Oncológico del Sureste, Murcia, España. La mediana de edad fue de 54 años (rango, 31-89; 145 (48,49% pacientes con cáncer de mama derecha y 154 (51,50% de mama izquierda. Con base en la 7ª ed AJCC, la etapificación patológica fue: 118 (39,5% pacientes T1, 114 (38,1% T2, 43 (14,1% T3, 11 (3,8% T4, 5 (1,7% Tis, 4 (1,3% Tx; 137 pacientes (45,8% eran N0, 94 (31,5% N1, 45 (15% N2, 20 (6,70% N3 y 3 (1,00% Nx. Todos los pacientes se sometieron a RTE con técnica 3D conformada con esquema hipofraccionado de 2,67 Gy/día, en 15 fracciones para una dosis total de 40.05 Gy. Se realizó irradiación electiva a la región supraclavicular en 169 pacientes, con igual fraccionamiento. El 100% de la muestra se sometió a cirugía, el 84,3% recibió quimioterapia (66,21% postoperatoria y 18,1% neoadyuvante. Resultados: sesenta y siete pacientes (23,1% presentaron toxicidad cutánea grado 2 al finalizar el tratamiento. No se reportó toxicidad cutánea aguda severa. Conclusión: el esquema de hipofraccionamiento empleado en cáncer de mama es factible y no ha demostrado incremento en la toxicidad aguda severa a nivel de piel.

  16. Aplicación de un antioxidante en dientes tratados con tetraciclinas y/o MTA.

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    Bermúdez Semprún, María Esther

    2014-01-01

    Una vez que el diente erupciona en la cavidad bucal, lo hace con una formación radicular incompleta, se denomina diente inmaduro o con ápice abierto. La patología pulpar, como secuela de caries o de lesión traumática puede interferir en la vitalidad pulpar, conllevando a una interrupción de la formación normal de la raíz y como consecuencia, una raíz de paredes delgadas y propensas a la fractura. A partir del 2001 se introdujo la revascularización, que tiene la capacidad de formar tejido ...

  17. Trabajos de estudiantes: un caso de colecistitis litiasica tratado con colecistotomia (colecistendesis)

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    García Torres, Aristides

    2011-01-01

    Nombre de la enferma: M. de los A. H.Cama N° 4.Edad, 29 añosEstado civil: SolteraProfesión, Oficios domésticosProcedencia, traslado del Servicio de Clínica Terapéutica del Prof. Salgar verificado el 16 de mayo de 1945.Ultima residencia, La Ciudad.Natural de Simijaca (Cundinamarca).Fecha de entrada al Hospital, 18 de abril de 1945.Fecha de salida del Hospital, 31 de mayo de 1945.Causa de la salida, mejoría.Tratamiento practicado en el Servicio del Prof. Piñeros, Colecistotomía, con extracción ...

  18. Poblaciones linfocitarias, células dendríticas y perfil de citoquinas en ratones con melanoma tratados con Uncaria tomentosa

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    Iván Lozada-Requena

    2015-12-01

    Full Text Available Objetivos. Evaluar el efecto inmunomodulador sobre poblaciones linfocitarias, células dendríticas (DC, citoquinas Th1/Th2/Th17 (T-helper e inflamatorias en el ámbito sistémico y/o en el microambiente tumoral de ratones con o sin melanoma. Materiales y métodos. Se obtuvieron muestras de sangre periférica y/o de tumores primarios de ratones con melanoma B16 tratados o no con un extracto hidroalcohólico de Uncaria tomentosa (UT con 5,03% de alcaloides oxindólicos pentacíclicos (UT-POA obtenido de la corteza de la planta. Todos los ensayos de medición de células y citoquinas fueron realizados por citometría de flujo. Resultados. UT-POA a nivel sistémico incrementa la relación CD4/CD8a (Cluster of Differenciation, mientras que la activación celular es inversamente proporcional; incrementa la proporción de DCm (DC mieloides; induce un perfil Th1 proinflamatorio y reduce la respuesta Th17. TNF-a (tumor necrosis factor alpha y IL-17A (interleuquina correlacionan positiva y negativamente con la relación CD4/CD8a. Conclusiones. El incremento de Th1 (TNF-a puede tener como consecuencia el incremento de linfocitos CD4 o la activación de macrófagos M1. Aunque UT-POA muestra un incremento de DCm, este no es dosis-dependiente. La disminución de Th17 (IL-17A puede favorecer el funcionamiento de los linfocitos CD8a. UT-POA muestra mejores efectos inmunomoduladores en el ámbito sistémico que intratumoral

  19. Poblaciones linfocitarias, células dendríticas y perfil de citoquinas en ratones con melanoma tratados con Uncaria tomentosa

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    Iván Lozada-Requena

    2015-10-01

    Full Text Available Objetivos. Evaluar el efecto inmunomodulador sobre poblaciones linfocitarias, células dendríticas (DC, citoquinas Th1/Th2/Th17 (T-helper e inflamatorias en el ámbito sistémico y/o en el microambiente tumoral de ratones con o sin melanoma. Materiales y métodos. Se obtuvieron muestras de sangre periférica y/o de tumores primarios de ratones con melanoma B16 tratados o no con un extracto hidroalcohólico de Uncaria tomentosa (UT con 5,03% de alcaloides oxindólicos pentacíclicos (UT-POA obtenido de la corteza de la planta. Todos los ensayos de medición de células y citoquinas fueron realizados por citometría de flujo. Resultados. UT-POA a nivel sistémico incrementa la relación CD4/CD8a (Cluster of Differenciation, mientras que la activación celular es inversamente proporcional; incrementa la proporción de DCm (DC mieloides; induce un perfil Th1 proinflamatorio y reduce la respuesta Th17. TNF-a (tumor necrosis factor alpha y IL-17A (interleuquina correlacionan positiva y negativamente con la relación CD4/CD8a. Conclusiones. El incremento de Th1 (TNF-a puede tener como consecuencia el incremento de linfocitos CD4 o la activación de macrófagos M1. Aunque UT-POA muestra un incremento de DCm, este no es dosis-dependiente. La disminución de Th17 (IL-17A puede favorecer el funcionamiento de los linfocitos CD8a. UT-POA muestra mejores efectos inmunomoduladores en el ámbito sistémico que intratumoral

  20. Estudio del grado de satisfacción en pacientes edéntulos totales tratados con implantes

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    Regina Mestre Aspa

    2001-07-01

    Full Text Available El objetivo de este estudio fue evaluar el grado de satisfacción de los pacientes edéntulos totales tratados en nuestro servicio mediante implantes dentales y la colocación posterior de una prótesis implantosoportada (sobre dentadura o prótesis fija. Para evaluar el grado de satisfacción se realizó una encuesta telefónica con seis preguntas: 1 ¿Siente algún tipo de dolor en los implantes? 2 ¿Tiene algún problema cuando habla? 3 ¿Se atreve a reír con esta prótesis? 4 ¿Puede comer cómodamente? 5 ¿Está satisfecho en general con el tratamiento recibido y el resultado de éste? 6 ¿Repetiría el tratamiento? Para cuantificar la satisfacción de los pacientes se valoraron de forma individual y de forma conjunta las respuestas a estas preguntas. De los datos obtenidos destacaremos que el 65% de los pacientes encuestados estaban satisfechos con el tratamiento recibido y con el resultado de éste, independientemente de si estos eran portadores de una prótesis fija o de una sobre dentadura. También el 65% de los pacientes repetirían el tratamiento. Mediante el test de c2 (grado de significación pThe aim of this study was to evaluate the satisfaction rate of total edentolous patients treated in our service with dental implants and the placement of a posterior implant-supported prothesis (overdenture or fixed. To evaluate the satisfaction we realize a telephonic inquest with six questions: 1 Do you feel any type of pain in your implants? 2 Do you have any trouble speaking? 3 Can you laugh with your prothesis? 4 Can you eat comfortably? 5 Are you satisfied in general with the treatment recieved and with its result? 6 Could you repeat the treatment? Toquantifie the satisfaction of the patients we value each answer individually and also all conjunctly. As a results, we obteined that 65% of patients were satisfied with the treatment and with its result, independently of the prothesis type they wear. Also a 65% of patients would repeat the

  1. Caracterización de un suelo arcilloso tratado con hidróxido de calcio

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    Óscar Eduardo Pardo Naranjo

    2012-06-01

    Full Text Available Propone una metodología para el tratamiento de suelos susceptibles (arcillas mediante la incorporación del hidróxido de calcio como estabilizante, en busca del mejoramiento de sus características físicas, mecánicas y químicas. La caracterización del suelo consistió en la elaboración de una serie de ensayos de laboratorio que determinaran sus características físico-mecánicas y químicas. Además de esto, se diseñaron mezclas de suelo-hidróxido de calcio en las que se varió el porcentaje de aditivo entre el 2% y el 12%, con el fin de observar las tendencias de sus características y poder así seleccionar el porcentaje óptimo de hidróxido de calcio, que proporcionará mejores condiciones de trabajabilidad del suelo estudiado. Como resultado se obtuvo una mezcla que optimizó el comportamiento del suelo original en cuanto a sus propiedades de plasticidad, resistencia y estabilidad, transformando un suelo pobre en uno adecuado para estructuras de pavimentos.

  2. Caracterización de un suelo arcilloso tratado con hidróxido de calcio

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    Carlos Hernando Higuera Sandoval

    2013-02-01

    Full Text Available Propone unametodología para el tratamiento de suelos susceptibles (arcillas mediante la incorporación del hidróxido de calcio como estabilizante, en busca del mejoramiento de sus características físicas, mecánicas y químicas. La caracterización del suelo consistió en la elaboración de una serie de ensayos de laboratorio que determinaran sus características físico-mecánicas y químicas. Además de esto, se diseñaron mezclas de suelo-hidróxido de calcio en las que se varió el porcentaje de aditivo entre el 2% y el 12%, con el fin de observar las tendencias de sus características y poder así seleccionar el porcentaje óptimo de hidróxido de calcio, que proporcionará mejores condicionesde trabajabilidad del suelo estudiado. Como resultado se obtuvo una mezcla que optimizó el comportamiento del suelo original en cuanto a sus propiedades de plasticidad, resistencia y estabilidad, transformando un suelo pobre en uno adecuado para estructuras de pavimentos.

  3. Calidad de vida y satisfacción del paciente anciano no oncológico con dolor irruptivo tratado con fentanilo sublingual

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    J. Pérez-Cajaraville

    2016-02-01

    Full Text Available Introducción: La prevalencia del dolor irruptivo (DI es > 55 % en los pacientes no oncológicos y cercana al 70 % en pacientes con dolor crónico. El DI deteriora el estado funcional y emocional de los pacientes, lo cual se traduce en una menor calidad de vida. Se ha descrito que un 50 % de la población oncológica anciana podría padecerlo, pero en ancianos no oncológicos los datos disponibles sobre el tratamiento del DI son limitados. Objetivos: El objetivo primario de este estudio fue valorar la calidad de vida y la satisfacción del paciente anciano no oncológico con DI tratado con fentanilo sublingual. Los objetivos secundarios fueron evaluar el cambio en la intensidad del dolor, el número de episodios de DI y el tiempo de respuesta al tratamiento con fentanilo sublingual, y describir su perfil de seguridad. Material y métodos: Estudio retrospectivo multicéntrico realizado en 78 pacientes con un periodo de recogida de datos de un mes. Se eligió a pacientes > 70 años, con DI (EVA ≥ 6 y tratamiento de base con opioides, a los cuales se les hubiera prescrito citrato de fentanilo sublingual para el tratamiento del DI. Se incluyeron datos basales (control 0 y de las visitas/controles telefónicos a los 3, 15 y 30 días (controles 1, 2 y 3, respectivamente. Resultados: Al inicio del estudio, el valor medio de EVA fue de 7,52 (DE 0,90 y la afectación media en las actividades cotidianas en el cuestionario CBD fue de 6,7/10 (DE 1,21. Al finalizar el estudio los pacientes tuvieron una afectación de 4,36/10 en sus actividades diarias a causa del dolor (p < 0,0001. El promedio de los ítems de intensidad del dolor (CBD se redujo 2,38 puntos vs. basal (p < 0,0001. La puntuación media en las dimensiones de salud física y salud mental del cuestionario SF-12 subió 2,46 y 9,27 puntos, respectivamente, vs. basal, de forma significativa (p = 0,0051 y p < 0,0001, respectivamente. El 75,32 % de los pacientes y el 92,21 % de los investigadores

  4. Remoción de color de lixiviados tratados biólogicamente mediante oxidación con permanganato de potasio

    OpenAIRE

    Bastidas, Mónica Lorena; Castro Gómez, Julio Andrés

    2004-01-01

    En el presente trabajo se estudió la oxidación química con permanganato de potasio y un oxidante a base de manganato de nombre comercial manhídrox, del lixiviado tratado previamente en un reactor biológico anaerobio de flujo ascendente (UASB) en el Relleno Sanitario La Esmeralda, con el propósito central de remover el color de dichas aguas residuales y observar el efecto en la remoción de turbiedad, DQO y DBO5. Los ensayos realizados mostraron que el permanganato de potasio es más efectivo, c...

  5. Medidas tecnológicas de protección en el tratado de libre comercio con los Estados Unidos de Norteamérica

    Directory of Open Access Journals (Sweden)

    Jhonny Antonio Pabón Cadavid

    2007-11-01

    Full Text Available Las medidas tecnológicas de protección de contenidos tutelados por el derecho de autor, gracias a los tratados internacionales de 1996 de la OMPI son objeto obligatorio de protección jurídica, en Colombia la legislación que ha abordado el tema ha sido de forma exclusiva la penal. El tratado de libre comercio con los Estados Unidos, en el marco de los aadpic aumentados, establece normas relacionadas con las medidas tecnológicas de protección que replican el modelo de la dmca de 1998. Un tema que ha tenido tantas variaciones, en especial frente a las excepciones a la elusión de las medidas, es necesario que sea abordado con una agenda legislativa moderna, que incluya los desarrollos que ha tenido el tema durante los últimos 10 años. Se presenta un análisis de las normas propuestas en el tlc y se propone que el legislador Colombiano dentro de la soberanía que le es propia, legisle el tema mucho más allá de lo propuesto en el TLC.

  6. Medidas tecnológicas de protección en el tratado de libre comercio con los Estados Unidos de Norteamérica

    Directory of Open Access Journals (Sweden)

    Jhonny Antonio Pabón Cadavid

    2007-01-01

    Full Text Available Las medidas tecnológicas de protección de contenidos tutelados por el derecho de autor, gracias a los tratados internacionales de 1996 de la ompi son objeto obligatorio de protección jurídica, en Colombia la legislación que ha abordado el tema ha sido de forma exclusiva la penal. El tratado de libre comercio con los Estados Unidos, en el marco de los aadpic aumentados, establece normas relacionadas con las medidas tecnológicas de protección que replican el modelo de la dmca de 1998. Un tema que ha tenido tantas variaciones, en especial frente a las excepciones a la elusión de las medidas, es necesario que sea abordado con una agenda legislativa moderna, que incluya los desarrollos que ha tenido el tema durante los últimos 10 años. Se presenta un análisis de las normas propuestas en el tlc y se propone que el legislador Colombiano dentro de la soberanía que le es propia, legisle el tema mucho más allá de lo propuesto en el tlc.

  7. Comportamiento detersivo de las formulaciones ecológicas en la extracción de grasas y proteínas en tejido de algodón aprestado y tratado con diversos suavizantes

    OpenAIRE

    Carrión Fité, Francisco Javier; Serra Gasol, Miquel

    2002-01-01

    En el presente trabajo se efectuó un estudio del comportamiento detersivo producido por una formulación ecológica, aplicada para el lavado de un tejido de algodón aprestado con una resina DMDHEU y tratado con diferentes suavizantes catiónicos, del tipo de amonio silicona y esterquat. A estos tejidos se aplicaron, antes del lavado, dos impurezas del tipo proteína y una tipo aceitosa. Los efectos del detergente, en la extracción de tales impurezas del tejido aprestado y tratado con los diferent...

  8. Función adrenal y metabolismo lipídico en niños asmáticos tratados con budesonida

    OpenAIRE

    Paoli-de Valeri Mariela; Zerpa-de Miliani Yajaira; Valeri-Dávila Ezio G.; Bellabarba Gabriela

    1999-01-01

    Objetivo. Evaluar el efecto de bajas dosis de budesonida inhalado sobre la función adrenal y el metabolismo lipídico en niños asmáticos. Material y métodos. Se estudiaron: 10 niños asmáticos (edad promedio, 8.6 años) tratados con budesonida inhalado (200-300 µg/día) por un lapso mayor a tres meses (grupo A); 15 niños asmáticos (edad promedio, 7.8 años) sin tratamiento esteroideo (grupo B), y 10 niños no asmáticos (grupo C). Se determinaron los niveles de cortisol basal y postestímulo con ACTH...

  9. EVALUACIÓN DEL MANEJO TUBULAR DEL POTASIO EN PACIENTES CIRRÓTICOS TRATADOS CON COMBINACIÓN DE FUROSEMIDA + ESPIRONOLACTONA

    Directory of Open Access Journals (Sweden)

    Algranati L

    2011-01-01

    Full Text Available Los cirróticos desarrollan hiperaldosteronismo secundario en estadios avanzados de su enfermedad, requiriendo tratamiento con furosemida + espironolactona. El manejo tubular del potasio (K en estos pacientes bajo dicho esquema diurético combinado (antagónico no ha sido aun estudiado, por lo cual decidimos describir el valor de la excreción fraccional (EF de potasio y del gradiente transtubular de potasio (GTTK en esta población bajo dichos diuréticos. Material y Método: Se evaluó prospectivamente la EF de sodio (Na, EFK y GTTK en 18 pacientes (11 hombres, edad promedio 56 años, normokalémicos, cirróticos (Ci compensados estadios Child Pugh A, B y C, MELD medio 22, portadores de filtrado glomerular, sedimento urinario y ecografía renal normales, tratados con furosemida + espironolactona y dieta hiposódica. Grupo control: 10 voluntarios sanos bajo igual dieta (S. Análisis estadístico: Wilcoxon. Resultados: Kalemia (mmol/l: 4 ± 0.5 (Ci vs. 4 ± 0.3 (S, p=NS; EFNa (%: 0.8 ± 0.4 (Ci vs. 0.5 ± 0.3 (S p=NS; EFK (%: 9.1 ±3 (Ci vs. 10±2 (S, p=NS; GGTK: 6 ±2 (Ci vs. 4 ±1 (S, p=0.04. Conclusión: Observamos que en cirróticos tratados con furosemida + espironolactona, existe un incremento significativo de la excreción urinaria de potasio, sólo evidenciable por el GTTK.

  10. Avaliação de parâmetros antioxidantes em ratos tratados com sevoflurano Evaluación de parámetros antioxidantes en ratones tratados con sevoflurano Evaluation of antioxidant parameters in eats treated with sevoflurane

    Directory of Open Access Journals (Sweden)

    Francisco J. L Bezerra

    2010-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O sevoflurano é um éter halogenado com flúor que sofre biotransformação hepática através do citocromo P450 2E1. Éteres halogenados que sofrem biotransformação pelo P450 2E1 podem produzir espécies reativas do oxigênio (ERO e promover enfraquecimento do sistema de defesa antioxidante. O objetivo deste trabalho foi investigar a relação entre a atividade das enzimas antioxidantes eritrocitárias e o sevoflurano. MÉTODO: Os animais foram distribuídos em quatro grupos: Grupo 1 controle: apenas oxigênio a 100% (1 L.min-1 por 60 minutos durante 5 dias consecutivos; Grupo 2 - sevoflurane 4,0% em oxigênio a 100% (1 L.min-1 por 60 minutos durante 5 dias consecutivos; Grupo 3 - isoniazida (i.p., 50 mg.kg-1 de peso corporal /dia, durante 4 dias e em seguida tratados apenas com oxigênio a 100% (1 L.min-1 por 60 minutos durante 5 dias consecutivos; Grupo 4 - isoniazida por via intraperitoneal na dose de 50 mg.kg-1 de peso corporal, diariamente durante 4 dias, seguido da administração do sevoflurane a 4,0% em oxigênio a 100% (1 L.min-1 por 60 minutos durante 5 dias. Após 12 horas da última exposição ao sevoflurane, os animais foram sacrificados e o sangue foi coletado através da veia porta para análise da atividade das enzimas antioxidantes. RESULTADOS: Aumento da atividade específica da glicose-6-fosfato desidrogenase, diminuição da atividade específica da catalase, principalmente no grupo de animais pré-tratados com isoniazida e, em seguida, tratados com sevoflurano. A glutationa peroxidase não apresentou alteração na sua atividade. CONCLUSÕES: A interação do sevoflurano com indutores enzimáticos do citocromo P450 2E1 pode propiciar a instalação do estresse oxidativo caso a exposição se torne prolongada e repetitiva.JUSTIFICATIVA Y OBJETIVOS: El sevoflurano es un éter halogenado con flúor que sufre una biotransformación hepática a través del citocromo P450 2E1. Los

  11. PREVALENCIA Y FACTORES ASOCIADOS DE LA AUTOMONITORIZACIÓN GLUCÉMICA EN PACIENTES DIABÉTICOS TIPO 2 NO TRATADOS CON INSULINA EN LA COMUNIDAD VALENCIANA

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    Diego Cano-Blanquer

    2013-01-01

    Full Text Available Fundamentos: La utilidad de la automonitorización de la glucemia (AMGS en pacientes con diabetes tipo 2 (DM2 no tratados con insulina (NTI es objeto de controversia.. Los objetivos de este trabajo son describir la prevalencia de AMGS en sujetos con DM2 NTI en la Comunidad Valenciana y analizar los factores asociados a su a su uso. Método: Estudio transversal en 83 consultas de atención primaria mediante revisión de la historia clínica electrónica y entrevista a 573 sujetos con DM2-NTI. Se analizó la asociación entre la indicación de AMGS y las características del paciente, médico y organizativas. Resultados: 289 (50,4% de los pacientes con DM2-NTI utilizaban AMGS. En el análisis multivariante el uso de AMGS se asoció a la menor edad (OR:2,3 para 65-84 y 6,0 para 8, vs <7, número de antidiabéticos orales prescritos (ADO (OR:2,5, 4,1 y 5,7 para 1, 2 ó 3+ ADO vs no tratamiento farmacológico, tipo de ADO (mayor en sulfonilureas y glitazonas y enfermedad respiratoria crónica (OR:0,5. Controlando el efecto de estos factores, el uso de AMGS se asoció adicionalmente a los años de ejercicio profesional del médico y a la asistencia en algunos departamentos sanitarios. Conclusiones: La mitad de los pacientes con DM-NTI utilizan AMGS. Su uso se asoció fuertemente a las características clínicas de los pacientes, aunque algunos factores no clínicos explican parte de la variabilidad en su utilización.

  12. Adenocarcinoma de recto y ano en paciente con enfermedad de Crohn tratado con infliximab Adenocarcinoma of the rectum and anus in a patient with Crohn´s disease treated with infliximab

    Directory of Open Access Journals (Sweden)

    J. Egea Valenzuela

    2010-08-01

    Full Text Available In the present paper, we report the case of a patient with long-standing Crohn´s disease and multiple complications that, after receiving treatment with infliximab, was diagnosed with an adenocarcinoma of the rectum and anus that required radical surgery, later presenting multiple metastases. In the discussion, characteristics and major risk factors for colorectal cancer in patients with inflammatory bowel disease will be largely reviewed, and current studies will be analyzed in connection with the appearance of neoplasms in patients being treated with biologics.Presentamos el caso de un paciente con enfermedad de Crohn de larga evolución y con múltiples complicaciones de su enfermedad que, tras recibir tratamiento con infliximab, es diagnosticado de un adenocarcinoma de recto y ano que precisa cirugía radical, presentando posteriormente metástasis múltiples. Se repasarán durante la discusión las características y los factores de riesgo más importantes del cáncer colorrectal en pacientes con enfermedad inflamatoria intestinal, y se analizarán los trabajos existentes hasta la fecha en relación con la aparición de neoplasias en pacientes tratados con fármacos biológicos.

  13. Rabdomioma cardiaco tratado quirúrgicamente con éxito y revisión de la literatura

    OpenAIRE

    Cigarroa López,Ángel; García Jiménez,Yoloxóchitl; Yáñez Gutiérrez,Lucelly; Jiménez Arteaga,Santiago; Martínez Sánchez,Arturo; Ortegón Cardeña,José; David Gómez,Felipe; Sánchez Soberanes,Agustín; López Gallegos,Diana; Riera-Kinkel,Carlos; Alva Espinosa,Carlos

    2005-01-01

    Los tumores cardiacos primarios son raros, con incidencia variable en todas las edades del 0.005 al 0.05%. En pacientes pediátricos, la incidencia es del 0.27%. Los tumores más frecuentes durante la infancia son los rabdomiomas cardiacos, considerados como benignos. Aunque la expresión clínica es amplia, en la mayoría de los casos son asintomáticos y se detectan por la presencia de soplos. En la etapa prenatal se manifiestan con arritmias o hydrops fetalis. En algunos neonatos y lactantes se ...

  14. Técnica de aclaramiento para dientes tratados endodónticamente con antecedentes de trauma dentoalveolar - reporte de caso

    OpenAIRE

    Mariño Poveda, Adriana Carolina

    2014-01-01

    La pigmentación, de un diente anterior no vital es una preocupación estética común para muchos pacientes. Los dientes no vitales con decoloración están comprometidos, debido a un trauma previo, caries y endodoncia. Las opciones de tratamiento rehabilitador son invasivas y debilitan la estructura dental remanente, cuestionando la viabilidad a largo plazo del diente. Este documento analiza un enfoque más conservador para el tratamiento de los dientes con decoloración. El caso ...

  15. PACIENTES DIABÉTICOS CON ENFERMEDAD CORONARIA MULTIVASO, TRATADOS MEDIANTE INTERVENCIONISMO CORONARIO PERCUTÁNEO / Diabetic patients with multivessel coronary disease treated by percutaneous coronary intervention

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    Suilbert Rodríguez Blanco

    2013-10-01

    Full Text Available Resumen Introducción: La enfermedad coronaria es la principal causa de morbilidad y mortalidad en los pacientes diabéticos. Muchos estudios han comparado el tratamiento médico más intervencionismo percutáneo con tratamiento médico más cirugía, en pacientes diabéticos con enfermedad de múltiples vasos. La cirugía de revascularización continúa siendo el tratamiento de elección. Objetivo: Caracterizar los pacientes diabéticos con enfermedad coronaria multivaso, tratados mediante intervencionismo coronario percutáneo. Método: Estudio observacional, descriptivo y transversal en 57 pacientes diabéticos con enfermedad de múltiples vasos, tratados mediante intervencionismo coronario percutáneo en el Laboratorio de Hemodinámica del Hospital "Hermanos Ameijeiras", entre enero de 2010 y julio de 2011. Resultados: Predominaron el sexo masculino (66,66 % y el grupo entre 50-64 años (36,85 %. El factor de riesgo cardiovascular más identificado fue la hipertensión arterial (54,38 %, seguido de la dislipidemia (49,12 %. En el grupo de edad más representado predominó la dislipidemia y el hábito de fumar. El diagnóstico más observado fue la angina de esfuerzo estable (45 pacientes, 78,95 %. El tipo de stent más utilizado fue el liberador de fármaco (54,39 % y la arteria más revascularizada fue la descendente anterior (36 pacientes, 63,15 %. Conclusiones: Se encontró una relación entre los pacientes sin éxito angiográfico con la dislipidemia y la obesidad; y entre los pacientes sin éxito del procedimiento, con el tabaquismo y también con la obesidad. / Abstract Introduction: Coronary heart disease is the leading cause of morbidity and mortality in diabetic patients. Many studies have compared medical therapy plus percutaneous intervention with medical therapy plus surgery in diabetic patients with multivessel disease. Bypass surgery remains the treatment of choice. Objective: To characterize diabetic patients with multivessel

  16. Síndrome de lisis tumoral en un paciente con cáncer de riñón tratado con sunitinib

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    Ezequiel Rodríguez-Reimúndes

    2011-04-01

    Full Text Available El síndrome de lisis tumoral (SLT es un trastorno metabólico que ocurre como consecuencia de una destrucción celular masiva. Se caracteriza por la presencia de hiperuricemia, hiperfosfatemia, hipocalcemia e hiperkalemia, y predispone al desarrollo de insuficiencia renal aguda. En la mayoría de los casos el SLT ocurre luego de instaurarse un tratamiento antitumoral y es más frecuente en tumores de alto grado de malignidad y alta sensibilidad a la quimioterapia. Presentamos el caso de un paciente con diagnóstico de cáncer de riñón recidivado que presenta un SLT e insuficiencia renal aguda luego de iniciar tratamiento con sunitinib.

  17. Effect of extract of Abrus precatorius on blood glucose con-centration of alloxan induced diabetic Albino Wistar Rats

    Institute of Scientific and Technical Information of China (English)

    Georgewill OA; Georgewill UO

    2009-01-01

    Objective:To evaluate the effect of extract of Abrus precatorius on blood glucose of alloxan induced albino wist-ar rats.Methods:Experimental animals received daily oral administration of extract of Abrus precatorius for 14 days.The effect of 200 mg/kg dose was studied during the treatment period.Results:There was a significant reduction in blood glucose concentration (P <0.05)with the mean blood glucose of the different groups as 5.0 ±0.3 for normal control,7.0 ±0.4 for diabetic control group and 4.0 ±0.2 for diabetic treated group. Conclusion:The findings of this study suggest that extract of Abrus precatorius has hypoglycemic effect.

  18. Outcome of sporadic amyotrophic lateral sclerosis treated With non-invasive ventilation and riluzole Sobrevida en pacientes con esclerosis lateral amiotrófica esporádica tratados con ventilación no invasiva y riluzole

    Directory of Open Access Journals (Sweden)

    Martín Sívori

    2007-08-01

    diagnóstico de sALS, según criterios definidos en El Escorial modificados, y fueron seguidos por 60 meses. Veintinueve pacientes recibieron NIV y 68 no (nNIV. En el grupo NIV la sobrevida media fue de 15.41 ± 7.78 meses vs. 10.88 ± 7.78 meses en nNIV (p= 0.028. La sobrevida media de los pacientes que recibieron riluzole (n=44 no fue diferente de la que no lo recibieron (n=53, aunque en el 4° y 5° mes los pacientes tratados con riluzole mostraron un escaso beneficio. Los pacientes que recibieron NIV y riluzole (n=18 tuvieron una sobrevida media de 16.61 ± 10.97 meses vs. 10.69 ± 7.86 meses para los que sólo recibieron tratamiento sintomático (n=42 (p= 0.021. La NIV prolongó significativamente la sobrevida en este grupo de pacientes. El riluzole, empleado como única terapéutica, no lo hizo. Los pacientes que combinaron los dos tratamientos tuvieron la mayor sobrevida.

  19. Características seminales de verracos alimentados con dietas adicionadas con ácido linoleico conjugado o nucleótidos, y comportamiento sexual de verracos castrados tratados con PGF2α.

    OpenAIRE

    Zamora Zamora, Vicente

    2010-01-01

    La composición nutrimental de la dieta afecta las características del semen y composición de nutrientes del espermatozoide. El comportamiento sexual en machos no está completamente relacionado con las hormonas esteroides producidas en el testículo. Se realizaron dos experimentos para evaluar el potencial de la adición de ácido linoleico conjugado (ALC; experimento 1) o nucleótidos (experimento 2) a dietas para verracos para mejorar las características seminales y modificar el perfil de ácidos...

  20. Modificación de biomarcadores histopatológicos e inmunohistoquímicos en las fibras musculares de cerdos tratados con clenbuterol

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    AM Molina

    2012-01-01

    Full Text Available El clenbuterol frecuentemente se ha utilizado de forma ilícita en el engorde del ganado, suponiendo ello un riesgo para la salud pública. La actual normativa prohíbe por tanto su uso en la cría del ganado. En este estudio se utilizaron 14 cerdos distribuidos al azar en dos grupos de estudio (n=7, uno control, y otro expuesto a 1 mg/kg de clenbuterol durante tres meses. Se utilizó el músculo longissimus lumbaris para la determinación de la concentración de clenbuterol, así como para la evaluación de los parámetros inmunohistoquímicos y el análisis estructural y ultraestructural de las fibras. El estudio de los distintos biomarcadores histopatológicos e inmunohistoquímicos de las fibras musculares, tras la exposición de los animales al clenbuterol, indicó la presencia de hipertrofia muscular, miofibrolisis y degeneración zenkeriana, observada tanto por microscopía óptica como electrónica. Mediante la técnica miosina ATP-asa se identificó un tipo de fibra denominada alterada en el grupo tratado que no apareció en el grupo control. Por tanto, se comprueba que el músculo longissimus lumbaris resulta una buena matriz para la investigación de la exposición a largo plazo a este compuesto en cerdos.

  1. Velocidad de la onda de pulso y la excreción urinaria de albumina en pacientes hipertensos tratados con Perindopril

    OpenAIRE

    J. E. Tobilli; C. A. Bellido; O. R. Iavícoli; Costa, M; Forcada, P

    2002-01-01

    La presión arterial sistólica, la presión arterial diastólica y la excreción urinaria de albúmina (EUA) han sido reconocidas como predictores de riesgo cardiovascular. Además, los trastornos de la compliance arterial (CA) evaluados mediante la velocidad de la onda de pulso elevada (VOP) están estrechamente relacionados con los cambios de la presión arterial y correlacionados con la mortalidad cardiovascular y la presencia de ateroesclerosis. El objetivo primario de este estudio ha sido determ...

  2. Manifestaciones cardiovasculares en pacientes tratados con hemodiálisis periódica por fístula arteriovenosa funcional

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    Ana S. Ayora Loaiza

    2016-06-01

    Conclusiones: No se encontró relación entre la localización de la fistula y los cambios en el sistema cardiovascular. El grupo de pacientes con fistula de más de cuatro años presentó mayores manifestaciones cardiovasculares y cambios significativos en el ecocardiograma.

  3. Evolución clínica de pacientes asmáticos tratados con inmunoterapia. Municipio Majibacoa, 2008-2013

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    Mailin Molina Leyva

    2015-11-01

    Full Text Available Se realizó un estudio cuasi-experimental de corte longitudinal en 50 pacientes asmáticos con edades  entre 5 y 54 años, atendidos en el Servicio de Alergología del municipio Majibacoa de la provincia de Las Tunas; con el objetivo de determinar la evolución clínica con inmunoterapia, en el período de enero 2008 a febrero de 2013. A los pacientes se les administró inmunoterapia específica de ácaros con extractos estandarizados, durante tres años o más de forma subcutánea. El asma bronquial predominó en el sexo femenino y en las edades comprendidas entre 5 y 14 años. Los antecedentes de atopia familiar fueron referidos por el mayor por ciento de los pacientes analizados. Según severidad de la enfermedad, antes del tratamiento prevalecieron los pacientes en la categoría persistente moderada. Se observó mejoría de los síntomas del asma en una elevada proporción de casos.

  4. Análisis de pacientes drepanocíticos tratados con hidroxiurea en el Hospital Nacional de Niños

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    Rasheda Maitland-Rouse

    2014-06-01

    Full Text Available Antecedentes: desde 1984 estudios comprobaron que la hidroxiurea aumentaba los niveles de hemoglobina fetal y del volumen corpuscular medio, por esta razón a partir de 1998 fue el primer fármaco aprobado para el tratamiento en la drepanocitosis. El objetivo de este estudio fue describir la respuesta y complicaciones de los pacientes drepanocíticos en tratamiento con hidroxiurea en el Hospital Nacional de Niños. Métodos: estudio transversal y retrospectivo, realizado en pacientes con drepanocitosis atendidos en el servicio de Hematología del Hospital Nacional de Niños de enero 2006 a diciembre 2009; se incluyeron pacientes cuyo expediente clínico reunía los criterios de inclusión. Resultados: se reclutaron 30 pacientes, 60% fueron del sexo masculino, la mayoría de los pacientes fueron de Guanacaste, San José y Limón con un 26.7%, 23.3%y 20.0% respectivamente. Un 87% de los pacientes mantuvieron una velocidad de crecimiento normal. Al comparar la hemoglobina fetal previa y posterior al tratamiento con hidroxiurea no se obtuvo diferencia estadísticamente significativa. Al comparar el número de transfusiones anuales previas y posteriores a tratamiento con Hidroxiurea, se obtuvo una diferencia estadísticamente significativa. Se observó una disminución en el número de hospitalizaciones; las principales causas de internamiento fueron las crisis vasooclusivas, procesos sépticos y los accidentes cerebro vasculares. Conclusión: el uso de hidroxiurea en los pacientes drepanocíticos se asoció a una reducción en el número de hospitalizaciones por crisis vasoclusivas, al mismo tiempo se redujo el número de transfusiones anuales, sin efectos secundarios y sin comprometer la velocidad de crecimiento de los pacientes.

  5. Velocidad de la onda de pulso y la excreción urinaria de albumina en pacientes hipertensos tratados con Perindopril

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    J. E. Tobilli

    2002-12-01

    Full Text Available La presión arterial sistólica, la presión arterial diastólica y la excreción urinaria de albúmina (EUA han sido reconocidas como predictores de riesgo cardiovascular. Además, los trastornos de la compliance arterial (CA evaluados mediante la velocidad de la onda de pulso elevada (VOP están estrechamente relacionados con los cambios de la presión arterial y correlacionados con la mortalidad cardiovascular y la presencia de ateroesclerosis. El objetivo primario de este estudio ha sido determinar la relación entre la VOP y la EUA en un grupo de pacientes no fumadores con hipertensión esencial y secundariamente evaluar los cambios producidos por un inhibidor de la enzima convertidora de angiotensina (perindopril sobre estas dos variables. En el estudio participaron setenta pacientes (33 hombres y 37 mujeres hipertensos no fumadores, sin tratamiento previo, de 50 ± 7 años (entre 35-69. La VOP de todos los pacientes fue estudiada por medio de un dispositivo computarizado (Complior en el período basal y a los seis meses de tratamiento con perindopril. También se determinó la EUA por el método de inmunodifusión radial al inicio del tratamiento y luego de seis meses de tratamiento con perindopril (4.6 ± 1.4 mg/día. Al finalizar el estudio se observó una reducción significativa de la presión arterial sistólica (PAS (160.2 ± 10.6 vs. 131.9 ± 7.1 mmHg, p<0.01, presión arterial diastólica (PAD (100.6 ± 5 vs. 81.6 ± 4.8 mmHg, p<0.01, VOP (13.4 ± 1 vs. 9.1 ± 0.9 m/seg, p<0.01 y EUA (42.2 ± 19.3 vs.11.1 ± 3.6 mg/día, p<0.01 al comparar estos valores con los del período basal. Por otra parte, la función renal evaluada por clearance de creatinina mostró una significativa mejoría en relación a los valores iniciales (87.5 ± 22.5 vs. 102.1 ± 23.5 ml/min, p<0.01. Asimismo, se apreció una significativa correlación positiva entre la EUA y la VOP al inicio del estudio (r = 0.81; p<0.01 y después de seis meses de tratamiento

  6. Morfología de la mucosa gástrica oxíntica en ratones jóvenes tratados con omeprazol

    OpenAIRE

    Corrons, Félix J.; Jurado, Susana B.; Peralta, R.; Pomini, H.; Errecalde, J.; Drut, Ricardo

    2010-01-01

    El omeprazol es un potente inhibidor de la bomba de protones usado como antiácido en la práctica diaria. Actúa uniéndose en forma covalente a la enzima de membrana H+/K+ ATPasa en la etapa final de la estimulación secretora. En pacientes adultos y pediátricos se describen cambios en la mucosa gástrica con altas dosis en cortos periodos de tiempo

  7. COMPORTAMIENTO DE UN MATERIAL GRANULAR NO TRATADO EN ENSAYOS TRIAXIALES CÍCLICOS CON PRESIÓN DE CONFINAMIENTO CONSTANTE Y VARIABLE BEHAVIOR OF AN UNBOUND GRANULAR MATERIAL IN CYCLIC TRIAXIAL TESTS WITH CONSTANT AND VARIABLE CONFINING PRESSURE

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    Hugo Alexander Rondón Quintana

    2008-12-01

    Full Text Available En un pavimento, cada una de las capas de la estructura experimenta bajo una carga vehicular ciclos de esfuerzo con componentes vertical, horizontal y de corte. Para el estudio de materiales granulares no tratados (utilizados para conformar capas de base y subbase, la mayor parte de las investigaciones se realizan empleando equipos triaxiales cíclicos en donde sólo la carga vertical es cíclica y la presión de confinamiento permanece constante durante el ensayo. Un ensayo que reproduce mejor la forma como se distribuyen los esfuerzos en estas capas es el ensayo triaxial cíclico con presión de confinamiento variable. En este ensayo se pueden modelar las componentes cíclicas tanto en el sentido vertical como horizontal. A pesar que son ensayos distintos, la ingeniería de pavimentos supone que la respuesta que experimentan estos materiales en estos ensayos es similar, lo anterior basado en algunos estudios realizados en la década de los setenta. En la presente investigación se diseña y desarrolla un programa experimental más detallado, para comparar el comportamiento que desarrolla un material granular no tratado en estos ensayos. De los resultados se evidencia que sólo para algunas trayectorias de esfuerzo, la dirección y la acumulación de la deformación vertical y volumétrica es similar.In a pavement structure, passing wheel loads impose cyclic stresses consisting of vertical, horizontal and shear components. Studies of the behavior of unbound granular materials (UGM, used for base and sub-base layers under cyclic loading are mostly performed using the axisymmetric triaxial test with constant confining pressure (CCP test and a cyclic variation of the axial stress. However, in this type of test only the vertical component of the cyclic stress path is considered. The oscillation of the horizontal stress can be reproduced by an additional cyclic variation of the confining pressure (VCP test. CCP and VCP tests are sometimes assumed to

  8. Inflamación celular en pacientes sometidos a cirugía electiva tratados con carbohidratos de baja carga glicémica, ácidos grasos omega 3 y antioxidantes

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    Lucrecia Arceo-Giorgana

    2016-03-01

    Full Text Available Antecedentes y Objetivos. La creciente complejidad de la Especialidad de Cirugía Plástica, ha inducido a su ramificación en varias subespecialidades. Una de las limitantes de la Cirugía Plástica ha sido la obesidad, enfermedad que conlleva complicaciones, aumenta el riesgo de inconvenientes y hace insuficiente el resultado proyectado para la estética y la función. El objetivo del presente trabajo es mostrar la importancia de la evaluación de la inflamación celular en la preparación de pacientes sometidos a cirugía electiva, previamente tratados con dieta con carbohidratos de baja carga glicémica, ácidos grasos omega 3 y 6 y antioxidantes. Material y Método. Realizamos un estudio longitudinal prospectivo cuasi-experimental no aleatorio de 23 pacientes que solicitaron intervenciones de Cirugía Plástica y aceptaron entrar en el protocolo de diagnóstico y tratamiento de inflamación celular. Primero realizamos el cuestionario de Reporte de Inflamación Celular "RIS" y tomamos a los pacientes pruebas de inflamación celular y de ácido eicosapentaenóico (EPA, ácido decosaexaenóico (DHA, acido araquidónico (AA y ácido dihomogamalinoléico (DGLA al ingreso y antes de la cirugía. Analizamos los datos con estadística descriptiva y comparamos los rangos con la prueba McNemar y de hipótesis t de student, del sistema SPSS. Resultados. Tras aplicar el RIS a los 23 pacientes antes de la preparación con dieta y tras un periodo de 1 a 3 meses, evaluamos las respuestas de cada uno de los cuestionarios a través de las pruebas no paramétricas, encontrando diferencia significativa en los 14 items. Se mejoró considerablemente a la alza el EPA; el DHA y el AA sin cambios significativos; y el DGLA disminuyó considerablemente. Con t de student encontramos variación significativa en los fosfolípidos del plasma y no hubo diferencia significativa entre los DHA y AA. Conclusiones. Demostramos así la efectividad de la dieta de los omegas

  9. Análisis de los cambios verticales óseos y dentoalveolares en pacientes tratados con aparatos funcionales de avance mandibular

    OpenAIRE

    Claudet Angulo, Paola Consuelo

    2016-01-01

    Los odontólogos deben tener amplios conocimientos sobre el crecimiento y desarrollo craneofacial, incluso para quienes ocasionalmente trabajan con niños, porque es difícil entender los trastornos que presentan los adultos sin conocer los procesos de desarrollo que han dado lugar a estos trastornos. Para ello se debe conocer, como es lógico, las pautas normales de crecimiento y los mecanismos implicados en el mismo.1 La variación es una ley básica de la biología. Las variaciones se dan a nivel...

  10. Study of hyperglycemia in non critically-ill patients receiving parenteral nutrition: incidence and risk factors Estudio de hiperglicemia en pacientes no críticos tratados con nutrición parenteral: incidencia y factores de riesgo

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    J. M. Llop

    2012-10-01

    Full Text Available Background: The objectives of our study on non-critically ill patients receiving parenteral nutrition (PN are to assess the incidence of hyperglycemia, the risk factors associated to its development and its influence in patient's evolution. Methods: A multicentric prospective observational study was performed in 9 hospitals. Four multivariate studies were developed to study the temporal risk in the occurrence of hyperglycemia (endpoint, intensive care unit (ICU admission, length of stay (LOS and death. Demographics, nutrients, drugs and clinical variables were collected. Independent variables studied as a possible risk factors were: sex, diabetes mellitus 2, baseline glycemia, albuminemia, pancreatitis, surgery in the 7 days prior to the end point, infection, insulin/somatostatin/corticoids administration during the study, glomerular filtration rate (GFR, and difference in the amount of glucose administration between the endpoint and one day before. Results: 119 patients were enrolled in the study, 25 cases of hyperglycemia were detected. In the clinical factors associated with PN hyperglycemia, significant variables were: surgery in the 7 days before the end point, GFR, glucose load in the 24 hours previous to the end point insulin administration and somatostatine/octreotide administration during the study. Hyperglycemia was significantly associated with ICU admission and increased LOS. Conclusions: Glucose administration in non-critically ill patients receiving PN should be reassessed downwards, especially in the immediate postsurgery, renal impairment and in patients treated with somatostatin analogues. It should be taken into account that an increase in glucose dose may lead to hyperglycemia in these patients and hyperglycemia correlates with longer hospital stay and increased frequency of ICU admissions.Antecedentes y objetivo: El estudio está dirigido a pacientes no críticos tratados con nutrición parenteral (NP y tiene como objetivo

  11. El ejercicio de la soberanía territorial de acuerdo con los tratados y principios del derecho internacional. El caso colombiano

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    Germán Ramírez Bulla

    2008-12-01

    Full Text Available La importancia del estudio del territorio como elemento del Estado, necesario para su existencia como sujeto del derecho internacional, que ejerce su soberanía territorial y debe respetar la de los demás como presupuesto para el mantenimiento de la paz y la seguridad internacionales, conduce a hacer algunas reflexiones sobre ciertos principios contenidos en las cartas de la onu y la oea y en otros instrumentos internacionales. El territorio como ámbito espacial en el que el Estado ejerce su soberanía, de manera excluyente para terceros que no deben intervenir en los asuntos internos, es también un espacio en el que las autoridades deben hacer cumplir el ordenamiento vigente. La Constitución del 91, al enumerar espacios que hacen parte de Colombia, reconoce la idea de la tridimensionalidad del territorio y cada uno de esos elementos es definido acogiendo o teniendo en cuenta normas del derecho internacional y del interno, con el objeto de precisar conceptos de manera que pueda haber una visión integral, no solamente del espacio físico, sino de la manera como el Estado se proyecta en sus relaciones exteriores, de acuerdo con una serie de principios que conforman un ordenamiento aceptado por la comunidad internacional.

  12. El ejercicio de la soberanía territorial de acuerdo con los tratados y principios del derecho internacional. El caso colombiano

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    Germán Ramírez Bulla

    2008-01-01

    Full Text Available La importancia del estudio del territorio como elemento del Estado, necesario para su existencia como sujeto del derecho internacional, que ejerce su soberanía territorial y debe respetar la de los demás como presupuesto para el mantenimiento de la paz y la seguridad internacionales, conduce a hacer algunas reflexiones sobre ciertos principios contenidos en las cartas de la onu y la oea y en otros instrumentos internacionales. El territorio como ámbito espacial en el que el Estado ejerce su soberanía, de manera excluyente para terceros que no deben intervenir en los asuntos internos, es también un espacio en el que las autoridades deben hacer cumplir el ordenamiento vigente. La Constitución del 91, al enumerar espacios que hacen parte de Colombia, reconoce la idea de la tridimensionalidad del territorio y cada uno de esos elementos es definido acogiendo o teniendo en cuenta normas del derecho internacional y del interno, con el objeto de precisar conceptos de manera que pueda haber una visión integral, no solamente del espacio físico, sino de la manera como el Estado se proyecta en sus relaciones exteriores, de acuerdo con una serie de principios que conforman un ordenamiento aceptado por la comunidad internacional.

  13. Características clínicas de pacientes tratados con terapia electroconvulsiva en un hospital público de Perú

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    Carla Cortez-Vergara

    2016-01-01

    Full Text Available Con el objetivo de describir el perfil de uso de la terapia electroconvulsiva (TEC en pacientes hospitalizados en el Instituto Nacional de Salud Mental "Honorio Delgado - Hideyo Noguchi" de Lima, Perú, se revisaron las historias clínicas de pacientes que recibieron TEC entre los años 2001 y 2011. Se aplicaron 419 cursos de TEC a 372 pacientes, con un total de 5439 aplicaciones; la esquizofrenia paranoide fue el diagnóstico más frecuente (70,7%, y la indicación más usual fue la resistencia al tratamiento (80,7%; asimismo, la respuesta clínica a la TEC fue buena en 70,1% de casos, mientras que los efectos secundarios, en general, fueron pasajeros y leves. El uso de TEC disminuyó a lo largo del periodo estudiado, pero fue muy tolerable y segura, especialmente en su versión modificada, y mostró una alta respuesta que la mantiene como un tratamiento psiquiátrico de primera línea.

  14. Perfil eletrocardiográfico e conteúdo glicogênico muscular de ratos tratados com nandrolona Perfil electrocardiográfico y contenido glicogénico muscular de ratones tratados con nandrolona Electrocardiographic profile and muscle glycogen content of rats treated with nandrolone

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    Carlos Alberto da Silva

    2010-12-01

    áfico, contenido glicogénico y de proteínas totales de los músculos cardíacos y esqueléticos, así como las concentraciones plasmática de albúmina. MÉTODOS: Los animales del grupo tratado recibieron la droga en la concentración 5mg/kg por vía subcutánea, dos veces por semana, durante tres semanas. Una vez por semana, los ratones fueron anestesiados con Pentobarbital sódico (50mg/Kg, ip y sometidos a evaluación por medio de electrocardiograma (ECG. Después del período experimental, muestras de los músculos cardíaco (ventrículo izquierdo - VI, sóleo (S, gastrocnemio blanco (GB, gastrocnemio rojo (GV, pectoral (P, intercostal (IC y diafragma (D fueron colectadas y analizadas. Los datos (media±epm fueron evaluados de acuerdo con ANOVA, segundo test de Tukey (p>0,05. RESULTADOS: Los ratones del grupo tratado presentaron alteraciones en los siguientes parámetros cardíacos: intervalo QRS, intervalo QTc y frecuencia cardíaca, caracterizados por un aumento de estos, teniendo el ápice en el intervalo de la semana de pretratamiento a la primera semana. Las reservas de glicógeno en el VI presentaron aumento de 127%. En relación a la cantidad de proteínas totales, una diferencia significativa fue constatada en el S, GV y D. En cuanto al perfil bioquímico y al hematocrito, fue observado un aumento en el porcentaje de eritrocitos. CONCLUSIÓN: El estudio muestra que importantes alteraciones cardíacas son provocadas precozmente, sugiriendo una jerarquía en la secuencia de modificaciones que comprometen la homeostasia del organismo.BACKGROUND: We considered both the indiscriminate use of steroids by top athletes and by physically active individuals. OBJECTIVE: To evaluate the effects of nandrolone decanoate on the electrocardiographic profile, glycogen content and total-protein profile of skeletal and cardiac muscles, as well as the plasma albumin concentrations. METHODS: The drug was administered subcutaneously, at a concentration of 5 mg/kg, twice a week for three

  15. Dosis elevadas de aspirina disminuyen la natriuresis en hipertensos tratados con enalapril High doses of aspirin reduce natriuresis in hypertensive patients treated with enalapril

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    Federico P. Di Gennaro

    2004-08-01

    Full Text Available Los inhibidores de la enzima convertidora de la angiotensina (IECA han demostrado ser eficaces en el tratamiento de la hipertensión arterial. Sin embargo, una importante proporción de hipertensos recibe además antiagregación plaquetaria con ácido acetil salicílico (AAS, y la consecuente inhibición de la síntesis de prostaglandinas con AAS atenuaría el efecto vasodilatador y la mayor excreción urinaria de sodio (Na u atribuidas al IECA. Nuestro objetivo fue evaluar la interacción de dos dosis de AAS (81 y 325 mg/día sobre el efecto hipotensor del enalapril y el impacto sobre la excreción de Na u en pacientes hipertensos. Se incluyeron 22 pacientes de ambos sexos, entre 35 y 65 años. Todos recibieron enalapril, dieta hiposódica y, secuencialmente separadas por período de «wash out», las dos dosis de AAS durante los setenta días del estudio. Se evaluó: presión arterial sistólica (PAS, diastólica (PAD, media (PAM y Na u en un período basal (PB, con 325 y 81 mg de AAS (P1 y P2 respectivamente. Comparando el PB con P1 y P2, se observó una reducción significativa de la PAS, PAD, PAM (pAngiotensin converting enzyme inhibitors have been shown to be useful in the treatment of essential hypertension while anti-platelet agents improve the overall cardiovascular risk profile in this population. Our aim was to assess the interaction of two different aspirin (ASA doses -81 and 325 mg/day- with the antihypertensive effect of enalapril as well as their impact upon the urinary sodium excretion (Na u. A total of 22 patients between 35 and 65 years of age were included in a prospective double blind trial with a partial cross-over design. We excluded patients with secondary hypertension and recent use of anti-inflammatory drugs. Patients were placed on enalapril and a low sodium diet -<6 g of NaCl/day- and, sequentially, on two different doses of aspirin separated by a 10 day wash out period. Blood pressure (BP was measured at weekly visits

  16. Síndrome de lisis tumoral "espontáneo" en paciente con enfermedad de Crohn tratado con inmunosupresores Acute spontaneous tumor lysis syndrome in a patient with Crohn's disease taking immunosuppressants

    OpenAIRE

    C. Froilán Torres; P. Castro Carbajo; R. Pajares Villarroya; R. Plaza Santos; S. Gómez Senent; M. D. Martín Arranz; L. Adán Merino; E. Martín Arranz; N. Manceñido Marcos; R. Peces; D. Benito López

    2009-01-01

    El síndrome de lisis tumoral (SLT) es una complicación catastrófica del tratamiento de ciertas enfermedades neoplásicas. Si bien es más frecuente en pacientes con neoplasias hematológicas malignas tras el inicio de la quimioterapia, puede presentarse excepcionalmente, tras la necrosis espontánea de algunos tumores, en ausencia de tratamiento citostático. Clínicamente cursa con hiperuricemia, hiperfosfatemia, hipocalcemia, hiperpotasemia y fallo renal agudo. Presentamos el caso de un paciente ...

  17. Características y resultado a largo plazo de pacientes mayores con leucemia promielocítica aguda tratados con esquemas terapéuticos basados en ATRA más antraciclinas

    OpenAIRE

    Martínez Cuadrón, David

    2015-01-01

    La leucemia promielocítica aguda (LPA) es un subtipo de leucemia mieloide aguda que se diferencia por una morfología característica y la presencia de la t(15;17) y su correspondiente reordenamiento molecular PML/RARa. Clínicamente, no es infrecuente que se presente con coagulopatía, pudiendo ser la responsable de la muerte del paciente incluso antes del diagnóstico. No obstante, su buena respuesta al tratamiento con ácido holo-trans retinoico (ATRA) se ha traducido en una importante mejoría d...

  18. Treatment with pegylated interferon alpha 2b and ribavirin in patients unresponsive to previous treatments with standard interferon as monotherapy or combined with ribavirin Tratamiento con PEG interferón alfa 2b y ribavirina en enfermos previamente tratados con interferón estándar en monoterapia o combinado con ribavirina

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    F. Carnicer

    2005-05-01

    Full Text Available Background: little information is available on the effect of pegylated interferon (PEG and ribavirin (RBV in patients with chronic hepatitis due to virus C (CHC who were non-responders to previous treatment. Objectives: to evaluate response to treatment in patients who were non-responders to previous treatment. Methods: one hundred and twenty-four patients who were non-responders to previous treatment were included. All patients were treated with PEG alpha 2b interferon (dose: 1.5 mg/kg body weight and RBV (weight-dependent dosage. A qualitative PCR of virus C after six months was evaluated. In those in whom this was positive, treatment was discontinued; in those who were negative treatment was continued to the end of the year. Results: response following treatment (RFT was 35.4% (44 patients, and sustained viral response (SVR 29.8% (37 patients. No relation was observed between RFT, SVR and any previous treatment. RFT was dependent on low initial viremia and SVR was significantly and independently related to low serum hepatitis C RNA and a non-1 genotype. In general, treatment was well tolerated. Medication was discontinued in 5 patients, and doses reduced in 18. Conclusion: on retreatment with PEG and RBV a SVR of 29.8% was achieved in patients who had not responded to previous treatment, so its use in this group of patients is indicated.Introducción: existe poca información del resultado del tratamiento con interferón pegilado (PEG y ribavirina (RBV en enfermos con hepatitis crónica por virus C (HCC no respondedores a tratamientos previos. Objetivos: valorar la respuesta al tratamiento en enfermos no respondedores a tratamientos anteriores. Métodos: se incluyeron 124 enfermos no respondedores a tratamientos previos. Todos los pacientes fueron tratados con PEG interferón alfa 2b (dosis: 1,5 mg/kg peso y RBV (dosis ajustada al peso. Se valoró la PCR cualitativa del virus C al 6º mes. A los que la presentaban positiva se suspendió el

  19. Perfil clínico epidemiológico de los pacientes con cáncer tratados en una institución de tercer nivel. Manizales, Colombia, 1995-2004

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    Carlos Raúl Villegas

    2012-02-01

    Full Text Available Antecedentes: Los diagnósticos de cáncer son cada vez mayores y ello está asociado con el aumento de la expectativa de vida, la exposición a carcinógenos, la cobertura en salud, el tamizaje y la búsqueda activa de casos. En Estados Unidos se diagnostican 1’000,000 de casos nuevos y más de 500,000 muertes por año. Los costos de la atención y la incapacidad laboral son muy altos. En Colombia, el patrón de ocurrencia de esta enfermedad se constituye en un problema de salud pública. En Manizales, en el año 2004, se diagnosticaron 653 casos nuevos.Objetivo: Describir la población con diagnóstico de cáncer atendida en el Instituto Oncológico (ION SA de Manizales, Colombia, desde su fundación en el año 1995, hasta diciembre de 2004.Métodos: Se incluyeron 5,000 pacientes tratados durante 1995 a 2004. Las variables demográficas y clínicas se analizaron para establecer las frecuencias de presentación y los principales aspectos del manejo y los resultados del tratamiento.Resultados: Edad promedio 57 años +17.3; sexo femenino (65.6%; procedencia urbana (90.2%. La principal categoría ocupacional fue «Oficios varios» (61% seguida de «Técnico» (12.1%. Los diagnósticos con mayorfrecuencia fueron cáncer de mama (18.7%, cáncer de cérvix (13.1%, linfomas (7.7%, cáncer colorectal (6.4% y cáncer gástrico (4.7%. La mayoría de los pacientes (69.1% consultó después de dos meses de presentar síntomas.Las etapas clínicas III y IV fueron las más frecuentes en el momento de la consulta. Según la escala de Karnofsky, la capacidad funcional era buena al inicio del tratamiento. El manejo general se hizo con cirugía, quimioterapia yradioterapia. La toxicidad medicamentosa se presentó en 11.3% (567/5,000. La supervivencia a 5 años para hombres y mujeres fue de 61.2% y 72.3%, respectivamente (p<0.05.Conclusión: El perfil clínico y epidemiológico de los pacientes atendidos en el ION SA, mantiene las tendencias mundialmente

  20. Perfil clínico epidemiológico de los pacientes con cáncer tratados en una institución de tercer nivel. Manizales, Colombia, 1995-2004

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    Carlos Raúl Villegas

    2012-02-01

    Full Text Available Antecedentes: Los diagnósticos de cáncer son cada vez mayores y ello está asociado con el aumento de la expectativa de vida, la exposición a carcinógenos, la cobertura en salud, el tamizaje y la búsqueda activa de casos. En Estados Unidos se diagnostican 1’000,000 de casos nuevos y más de 500,000 muertes por año. Los costos de laatención y la incapacidad laboral son muy altos. En Colombia, el patrón de ocurrencia de esta enfermedad se constituye en un problema de salud pública. En Manizales, en el año 2004, se diagnosticaron 653 casos nuevos. Objetivo: Describir la población con diagnóstico de cáncer atendida en el Instituto Oncológico (ION SA de Manizales, Colombia, desde su fundación en el año 1995, hasta diciembre de 2004.Métodos: Se incluyeron 5,000 pacientes tratados durante 1995 a 2004. Las variables demográficas y clínicas se analizaron para establecer las frecuencias de presentación y los principales aspectos del manejo y los resultados del tratamiento.Resultados: Edad promedio 57 años +17.3; sexo femenino (65.6%; procedencia urbana (90.2%. La principal categoría ocupacional fue «Oficios varios» (61% seguida de «Técnico» (12.1%. Los diagnósticos con mayor frecuencia fueron cáncer de mama (18.7%, cáncer de cérvix (13.1%, linfomas (7.7%, cáncer colorectal (6.4% y cáncer gástrico (4.7%. La mayoría de los pacientes (69.1% consultó después de dos meses de presentar síntomas. Las etapas clínicas III y IV fueron las más frecuentes en el momento de la consulta. Según la escala de Karnofsky, la capacidad funcional era buena al inicio del tratamiento. El manejo general se hizo con cirugía, quimioterapia y radioterapia. La toxicidad medicamentosa se presentó en 11.3% (567/5,000. La supervivencia a 5 años para hombres y mujeres fue de 61.2% y 72.3%, respectivamente (p<0.05.Conclusión: El perfil clínico y epidemiológico de los pacientes atendidos en el ION SA, mantiene las tendencias mundialmente

  1. Síndrome de lisis tumoral "espontáneo" en paciente con enfermedad de Crohn tratado con inmunosupresores Acute spontaneous tumor lysis syndrome in a patient with Crohn's disease taking immunosuppressants

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    C. Froilán Torres

    2009-04-01

    Full Text Available El síndrome de lisis tumoral (SLT es una complicación catastrófica del tratamiento de ciertas enfermedades neoplásicas. Si bien es más frecuente en pacientes con neoplasias hematológicas malignas tras el inicio de la quimioterapia, puede presentarse excepcionalmente, tras la necrosis espontánea de algunos tumores, en ausencia de tratamiento citostático. Clínicamente cursa con hiperuricemia, hiperfosfatemia, hipocalcemia, hiperpotasemia y fallo renal agudo. Presentamos el caso de un paciente con enfermedad de Crohn en tratamiento inmunospresor, que desarrolló un síndrome de lisis tumoral espontáneo como debut de un plasmocitoma. Al ingreso, se objetivó un fracaso renal oligoanúrico que, a pesar de tratamiento precoz con hiperhidratación, alcalinización de la orina, urato-oxidasa y hemodiálisis, tuvo un desenlace fatal en 72 horas. Este caso reviste un interés particular por lo excepcional de la naturaleza "espontánea" del síndrome de lisis tumoral en ausencia de quimioterapia, por presentarse con una hiperuricemia extrema, probablemente la más alta de las recogidas en la literatura, y por la controversia actual de la terapia con inmunosupresores y/o biológicos en la enfermedad inflamatoria intestinal y su relación con el desarrollo de determinados tumores.Acute tumour lysis syndrome (TLS is a catastrophic complication of the treatment of certain neoplastic disorders. It most commonly occurs in association with hematologic malignancies and appears a few hours to a few days after initiation of specific chemotherapy, as the result from the release of intracellular components into the bloodstream due to abrupt malignant cell death. Acute spontaneous TLS is rare, and it has been described in leukemia and lymphoma and in some patients with solid tumors prior to institution of therapy. The syndrome is characterized by hyperuricemia, hyperphosphatemia, hypocalcemia, hyperkalemia, and acute oliguric or anuric renal failure due to

  2. Síndrome de lisis tumoral en un paciente con cáncer de riñón tratado con sunitinib Tumor lysis syndrome in a patient with a renal carcinoma treated with sunitinib

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    Ezequiel Rodríguez-Reimúndes

    2011-04-01

    Full Text Available El síndrome de lisis tumoral (SLT es un trastorno metabólico que ocurre como consecuencia de una destrucción celular masiva. Se caracteriza por la presencia de hiperuricemia, hiperfosfatemia, hipocalcemia e hiperkalemia, y predispone al desarrollo de insuficiencia renal aguda. En la mayoría de los casos el SLT ocurre luego de instaurarse un tratamiento antitumoral y es más frecuente en tumores de alto grado de malignidad y alta sensibilidad a la quimioterapia. Presentamos el caso de un paciente con diagnóstico de cáncer de riñón recidivado que presenta un SLT e insuficiencia renal aguda luego de iniciar tratamiento con sunitinib.The tumor mor lysis syndrome (TLS is a metabolic disorder resulting from a massive tumor breakdown. It is characterized by hyperuricemia, hyperphosphatemia, hypocalcemia and hyperkalemia and predisposes to acute renal failure. TLS usually occurs after the initiation of cytotoxic therapy and is more frequent in the case of neoplasias with a high proliferative rate or that are highly chemo-sensitive. We report the case of a man with a recurrent kidney cancer who presented with a TLS and acute renal failure after initiation of sunitinib.

  3. Pro-hepcidina, su relación con indicadores del metabolismo del hierro y de inflamación en pacientes hemodializados tratados o no con eritropoyetina recombinante Pro-hepcidin, its relation with indicators of iron metabolism and of inflammation in patients hemodialyzed treated or not with recombinant erythropoietin

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    Y. Barrios

    2010-08-01

    Full Text Available La hepcidina, péptido antimicrobiano, cuya síntesis se encuentra regulada por el estado del hierro e inflamación, juega un importante papel en la homeostasis del hierro en pacientes hemodializados (HD. Es medida a través de la prohepcidina sérica. Objetivo: Determinar los niveles séricos de prohepcidina y su relación con ferritina sérica, proteína C reactiva (PCR y albúmina en pacientes HD tratados o no con eritropoyetina recombinante (EPO, que asistieron a un Centro de Salud del Estado Carabobo-Venezuela. Metodología: Esta investigación es de tipo descriptiva, correlacional y de campo, cuya muestra estuvo conformada por 71 pacientes HD; 57 de éstos tratados con EPO. Se determinó prohepcidina sérica, ferritina, hemoglobina, hematocrito, PCR y albúmina. Se definió anemia (hemoglobina 10 mg/L. Resultados: El promedio para la prohepcidina fue de 397,5 ng/mL. Se observó un alto porcentaje de anemia (87,3% y un 22,5% de pacientes con ferritina sérica baja. No se observaron diferencias estadísticamente significativas para ferritina, albúmina, PCR y prohepcidina, entre pacientes con y sin tratamiento con EPO. Solo la variable PCR se correlaciona significativamente (rho = 0,276; p =0,020, con prohepcidina. Conclusión: Pacientes HD presentan niveles elevados de prohepcidina, esto pudiera deberse al proceso inflamatorio frecuentemente observado en estos pacientes y no al estado de hierro medido a través de los niveles de ferritina sérica.Hepcidin, an antimicrobial peptide which synthesis is regulated by iron status and inflammation, plays an important role in iron homeostasis in hemodialysed (HD patients. It is measured by measuring serum prohepcidin. Objective: To determine serum prohepcidin levels and their relationship with serum ferritin, C reactive protein (CRP, and albumin in HD patients treated or not with recombinant erythropoietin (EPO that attended the Health Centre of the Carabobo State in Venezuela. Methodology: This is

  4. Trastornos del sueño e incidencia de ansiedad y depresión en pacientes con dolor crónico no maligno tratados con opioides potentes Sleep disorders and incidence of anxiety and depresion in patients with chronic nonmalignant pain treated with strong opioids

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    I. Velázquez

    2012-04-01

    Full Text Available Introducción: acompañando al dolor están presentes otras funciones biológicamente importantes, no siempre bien reconocidas que suelen denominarse "co morbilidades", una de ellas es el sueño, aunque también se ha demostrado cierta concordancia entre el estado anímico y la nocicepción, siendo los dos estados de ánimo más estudiados y considerados como más relevantes en relación con el dolor crónico, la ansiedad y la depresión. Objetivo: el objetivo principal es evaluar la calidad del sueño en pacientes con dolor crónico no maligno (DCNM tratados con opioides potentes. Y como objetivos secundarios: analizar la incidencia de ansiedad y depresión en estos pacientes así como comparar la calidad del sueño e incidencia de ansiedad-depresión con distintas variables: tipo de opioide, género, sexo y tipo de dolor. Material y métodos: se consideró como universo del estudio a pacientes con DCNM tratados con el mismo opioide potente durante, al menos, tres meses y que acudieron a la consulta de Unidad del Dolor entre septiembre de 2009 y marzo de 2010. Fueron excluidos pacientes menores de 18 años, aquellos que no quisieron colaborar, diagnosticados de fibromialgia y los que estuvieran en tratamiento psiquiátrico. Como instrumento evaluador del sueño se utilizó el Cuestionario Oviedo de Sueño (COS y para mensurar el grado de ansiedad-depresión empleamos el Test Hospitalario de Ansiedad y Depresión (HAD en su valoración global. El análisis estadístico se realizó para las variables cualitativas mediante la χ² de Pearson. Las variables cuantitativas se compararon con un test de Student. Los valores con un p-valor menor que 0,05 fueron aceptados como significativos (95% de intervalo de confianza. Se usó el paquete estadístico SPSS.15 para Windows. Resultados: en la evaluación de los trastornos del sueño se encontraron diferencias significativas según el tipo de opioide consumido, siendo el grupo tratado con hidromorfoma el

  5. Constitución, Tratado de Libre Comercio Andino – Estados Unidos, Comunidad Andina

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    Marcel Tangarife Torres

    2007-12-01

    Full Text Available El presente escrito pretende hacer algunas reflexiones acerca de las relaciones jurídicas existentes entre la Constitución Política, el Tratado de Libre Comercio con Estados Unidos (TLC

  6. Audición y lenguaje en niños menores de 2 años tratados con implantación coclear Hearing and speech in children under 2 years of age with a cochlear implant

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    M. Manrique

    2004-12-01

    Full Text Available Fundamento. Valorar los resultados auditivos y de lenguaje en niños con una sordera congénita tratados mediante implantación coclear antes de los 2 años de edad y analizar las complicaciones surgidas en el proceso de selección, cirugía, programación y seguimiento de estos niños. Material y métodos. Se estudiaron 130 niños de forma prospectiva mediante la comparación de sus resultados individuales repetidos. Los niños se dividieron en dos grupos de edad: menores de 2 años (n=36 y niños entre 2 y 6 años (n=94. La valoración preoperatoria incluyó: 1. Historia, exploración física y ORL. 2. Valoración neuropediátrica, familiar y psicológica. 3. Potenciales auditivos troncoencefálicos. 4. Tomografía computarizada de alta resolución de peñascos. 5. Consejo terapéutico y consentimiento informado. La audición y el lenguaje se valoraron, antes y anualmente después de la cirugía (hasta 5 años, mediante pruebas logoaudiométricas en contexto cerrado y abierto, y con la prueba de Peabody y las escalas de Reynell. Resultados. La audición y el lenguaje mejoraron significativamente en todos los niños, independientemente de su edad. Los resultados, sin embargo, fueron mejores en los niños implantados antes de 2 años. Las pruebas de lenguaje mostraron que el desarrollo del lenguaje en estos niños es comparable al de niños normo-oyentes. La tasa de complicaciones no aumentó en los niños menores de 2 años. Conclusiones. La implantación coclear antes de los 2 años, ofrece unos resultados auditivos y de lenguaje mejores y más rápidos, en comparación con los alcanzados por niños de mayor edad, sin aumento de las complicaciones.Background. To compare the auditory abilities and speech performance of children with a profound prelingual bilateral hearing impairment, treated with a cochlear implant (CI before or after 2 years of age. To analyze the complications arising during the selection process of the children, or as a

  7. El Tratado De Dilectione Dei de Balduino de Ford

    OpenAIRE

    Carlos Hallet

    2004-01-01

    Figura relevante de la Orden del Císter, Balduino de Ford es un autor que se distingue por la originalidad de su espiritualidad. Su tratado De dilectione Dei es una meditación sobre el Primer Mandamiento, que nos invita a amar a Dios "con todo el corazón en sus beneficios, con toda el alma en sus promesas, con todas las fuerzas en sus juicios y con toda la mente en sus preceptos". Su reflexión, nutrida de la Biblia y expresada en un lenguaje marcado por la retórica latina, insiste en que el a...

  8. La ruptura de las relaciones diplomáticas: Una aproximación sistemática con una referencia especial a las consecuencias de la entrada en vigor del tratado de Lisboa en la praxis diplomática

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    Carles Pérez-Desoy i Fages

    2013-12-01

    Full Text Available Este trabajo tiene por objeto ofrecer un análisis sistemático de las distintas formas en que puede producirse la ruptura de relaciones diplomáticas entre dos estados soberanos, así como de las diversas fases en que puede descomponerse un proceso de este tipo, caracterizadas por la adopción de distintos tipos de medidas diplomáticas y la combinación de unas con otras (llamada a consultas, retirada de Embajadores, etc. lo que constituye un lenguaje de signos decodificable en términos diplomáticos, que ha sido poco estudiado desde un punto de vista sistemático. El elemento casuístico es, necesariamente, muy importante, máxime cuando las referencias a esta cuestión dentro de las normas codificadas del Derecho Diplomático son muy limitadas, y la jurisprudencia es con frecuencia inexistente. Por otra parte, la entrada en vigor del Tratado de Lisboa, y la puesta en marcha del Servicio de Acción Exterior Europeo (SEAE abre la posibilidad de que, en caso de crisis diplomática, acciones características de la diplomacia clásica puedan ser aplicadas también en el marco del proceso de toma de decisiones colectivas de la UE, ampliando así significativamente la panoplia de posibles medidas a adoptar. La entrada en vigor del Tratado de Lisboa abre también nuevas opciones teóricas de gran interés en el caso de ruptura de relaciones diplomáticas de un Estado Miembro de la UE con un tercer Estado, como por ejemplo la posible creación de una "sección de intereses" de ese Estado en el seno de la Delegación de la UE en ese país

  9. El Tratado de Lisboa (Un juego de espejos rotos

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    Juan Manuel de Faramiñán Gilbert

    2009-01-01

    Full Text Available El fracaso del Tratado por el que se establece una Constitución para Europa produjo un periodo de incertidumbre y perplejidad del que ha costado mucho sobreponerse. Por un momento, todo parecía resquebrajarse y se tuvo la sensación de que la imagen de unidad en la diversidad, que con tanta dificultad se había forjado, se partía hecha añicoscomo un espejo roto. No obstante, como en un “juego de espejos rotos”, el ideal europeísta se ha ido recomponiendo con un gran esfuerzo, dando lugar a un texto, el Tratado de Lisboa, que encierra una solución de compromiso con el fin de saldar la crisis cuando el futuro de la Unión Europea parecía oscurecerse. Como en los poemas de Alejandra Pizarnik, “cuando el palacio de la noche encierra su hermosura, pulsaremos los espejos hasta que nuestros rostros canten como ídolos” y, así fue como con un esfuerzo milimetrado se ha ido recomponiendo este rompecabezas de cristales con el fin de que en él se refleje, otra vez, la ansiada imagen global. Como se señala enPreámbulo del Tratado de Lisboa, deberemos estar resueltos a salvar una nueva etapa en proceso de integración europea y habrá que recordar “la importancia histórica de que la división del continente europeo haya tocado a su fin y la necesidad de sentar unas bases firmes para la construcción de la futura Europa”.

  10. Velocidad de la onda de pulso y la excreción urinaria de albumina en pacientes hipertensos tratados con Perindopril Pulse wave velocity and urinary albumin excretion in hypertensive patients treated with perindopril

    OpenAIRE

    J. E. Tobilli; C. A. Bellido; O. R. Iavícoli; Costa, M; Forcada, P

    2002-01-01

    La presión arterial sistólica, la presión arterial diastólica y la excreción urinaria de albúmina (EUA) han sido reconocidas como predictores de riesgo cardiovascular. Además, los trastornos de la compliance arterial (CA) evaluados mediante la velocidad de la onda de pulso elevada (VOP) están estrechamente relacionados con los cambios de la presión arterial y correlacionados con la mortalidad cardiovascular y la presencia de ateroesclerosis. El objetivo primario de este estudio ha sido determ...

  11. ACERO GALVANIZADO PRE-TRATADO CON PELÍCULAS HÍBRIDAS OBTENIDO POR RECUBRIMIENTO POR INMERSIÓN: INFLUENCIA DE LA VELOCIDAD DE RETIRADA DEL SUBSTRATO DEL SOL

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    Sandra Kunst

    2013-01-01

    Full Text Available En el presente trabajo, el acero galvanizado fue revestido con una película de silano obtenido a partir de un sol constituido por los precursores silano 3-(trimetoxisililpropil metacrilato (Tmspma y Tetraetoxisilano (Teos con adición de nitrato de cerio [0,01 M]. Se emplearon diferentes velocidades de retirada del sol (10, 20 y 30 cm.min-1, la caracterización de las películas fue realizada por Microscopía Electrónica de Barrido (MEB, perfilometría, ángulo de mojabilidad, potencial de circuito abierto, espectroscopia de impedancia electroquímica y polarización potenciodinámica. Los resultados muestran que la velocidad de retirada influye en el comportamiento electroquímico de las películas, las películas con mejor resistencia a la corrosión se obtiene con menores velocidades de retirada (10 y 20 cm.min-1.

  12. El sector agropecuario mexicano: un decenio con el Tratado de Libre Comercio de Norteamérica. La pobreza y la desigualdad se intensifican, crece la migración

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    Alicia Puyana

    2005-11-01

    Full Text Available México es una de las economías de tamaño intermedio más abiertas del orbe. Los aranceles se han abatido y el flujo de bienes, servicios y capitales, es prácticamente libre. Ha conformado zonas de libre comercio con casi todos los países desarrollados y con un amplio número de naciones en vía de desarrollo. Guardar coherencia con el TLCAN se ha convertido en el mapa de ruta que guía toda la estrategia comercial, de tal forma que el TLCAN innovó en muchos sentidos. Integró asimetrías inéditas e incorporó los acuerdos sobre propiedad intelectual, intercambio de servicios y los compromisos sobre inversión extranjera, que sólo se incluían en mercados comunes o en uniones económicas, además, sometió el sector agropecuario al proceso de desgravación arancelaria, cuando los esquemas de integración económica buscaban ganancias en productividad para el sector industrial. La importancia de estudiar los efectos del TLCAN sobre la agricultura mexicana se derivan de numerosos aspectos: la menor productividad de ésta, el peso de la economía campesina y la intensidad de la pobreza rural en la economía nacional.

  13. Las reglas de origen en los tratados de libre comercio

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    Marlon Iván Maldonado Narváez

    2014-01-01

    Full Text Available La presente revisión de los aspectos del libre comercio y las reglas de origen tiene como propósito hacer una evaluación general de los tratados de libre comercio en el ámbito colombiano, algunas de sus consecuencias y los ele- mentos que los componen, especialmente el referente al tema de las Reglas de Origen. El estudio de las Reglas de Origen, como uno de los aspectos fundamentales de las negociaciones de cualquier tratado de libre comercio, es determinante para entender si con ellas se busca proteger algún sector de la industria, o si por el contrario se establecen de manera abierta para facilitar el libre intercambio. Mediante una breve evaluación del Tratado de Libre Comercio entre Colombia y Estados Unidos, la postura asumida durante las negociaciones y los intereses de ambos países previamente a la firma del acuerdo se hace una valoración de lo riguroso que pueden ser las Reglas de Origen en dicho acuerdo.

  14. Contratos de Transporte Marítimo de Mercancías: del Harter Act norteamericano de 1893 a las Reglas de Rotterdam de 2008 y los tratados de libre comercio de Colombia con los Estados Unidos de América y la Unión Europea

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    Fernando Augusto Jiménez Valderrama

    2012-01-01

    Full Text Available La evolución de las instituciones jurídicas reguladoras de transporte marítimo de mercancías muestra un conflicto permanente entre los intereses del sector cargador y los intereses del sector naviero. El sistema establecido en la codificación continental y en el common law permitía acuerdos entre las partes como el establecimiento de cláusulas de "no responsabilidad" a favor de los navieros en el transporte marítimo. Esas cláusulas afectaban directamente los derechos de los cargadores a obtener una compensación por los daños y retrasos causados por las actividades de los navieros. Como reacción a este sistema, operadores de transporte propusieron una regla general basada en un mínimo de obligaciones que ambas partes debían respetar. Estos instrumentos están integrados a las Reglas de La Haya/Visby de 1924, las Reglas de Hamburgo de 1978 y recientemente en las Reglas de Rotterdam de 2008. Los tres instrumentos mencionados establecen un sistema imperativo para las partes en el contrato con exoneraciones y limitaciones de la responsabilidad del naviero. Los tratados de libre comercio entre Colombia y Estados Unidos de América y la Unión Europea crearon dos zonas de libre comercio entre Colombia y las dos economías más importantes del planeta.

  15. EFECTO DE VARIOS NIVELES DE TREONINA: LISINA SOBRE PARAMÉTROS PRODUCTIVOS EN CERDOS EN FINALIZACION TRATADOS CON RACTOPAMINA EFFECT OF VARIOUS LEVELS OF THREONINE: LYSINE ON PRODUCTION PARAMETERS IN FINISHING PIGS TREATED WITH RACTOPAMINE

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    Jaime Eduardo Parra Suescún

    2008-06-01

    Full Text Available Para determinar el efecto de la adición de Ractopamina (RAC y la relación Treonina:Lisina (Thr:Lys sobre los rendimientos productivos, se realizó un experimento durante 28 días. Para este fin se utilizaron 42 cerdos de aproximadamente 72,4± 2,3 kg, en los cuales se evaluó el efecto de dos niveles de RAC (5 y 10 ppm y tres relaciones Thr:Lys (0,60; 0,65 y 0,70 en la dieta, sobre el consumo de alimento diario (CDA, la ganancia diaria de peso (GDP, ganancia diaria de tejido magro libre de grasa (GDTMLG, y además, la eficiencia (Ef se expresó como GDTMLG en función del CDA. El experimento se realizó mediante un diseño completamente al azar con arreglo factorial 3x2 y se hizo un análisis de medidas repetidas en el tiempo. Todas las variables fueron medidas en cada animal 14 y 28 días después de iniciado el suministro de la dieta. Los valores medios/animal/día de todas las variables presentaron interacciones. En general se observó que niveles altos de Rac tuvieron un mejor desempeño con niveles bajos o intermedios de Thr:Lys mientras que los niveles bajos de Rac tuvieron mejores resultados con niveles altos de Thr:Lys. Por esta razón, es de esperarse que las diferencias entre las variables con los dos niveles de Rac se deban al manejo nutricional (relación Thr:Lys, ya que este factor influencia la magnitud de la respuesta. Desde el punto de vista productivo, la combinación a recomendar es 10 ppm de Rac y Thr:Lys 0,6.To determine the effect of adding Ractopamine (RAC and Threonine:Lysin ratio (Thr: Lys on the productive yields, an experiment during 28 days was made. 42 pigs of approximately 72,4± 2,3 kg were used in which the effect of two levels of RAC was evaluated (5 and 10 ppm and three relate Thr:Lys (0,60; 0,65 and 0,70 in the diet on the consumption of daily food (CDF, the daily weight gain (DWG, daily lean fat-free tissue gain (DLFFTG, and also, the efficiency (Ef was expressed as DLFFTG in function of CDF. A randomized

  16. La Alianza Bolivariana para las Américas-Tratado de Comercio de los Pueblos (ALBA-TCP: análisis de un proyecto de integración regional latinoamericana con una fuerte dimensión altermundialista.

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    Francisco Javier Ullán de la Rosa

    2011-11-01

    Full Text Available El ALBA-TCP es una de las organizaciones internacionales de más reciente creación. Es, sin duda, un proyecto original, diferente a las fórmulas de integración regional conocidas y preexistentes: fuertemente dirigido desde lo político, se propone como un mecanismo para planificar desde lo público las relaciones económicas y comerciales entre países, evitando o reduciendo en lo posible la competencia de mercado y fomentando la cooperación y las sinergias desde valores socialistas y de solidaridad. Y todo esto como expresión de una encrucijada ideológica donde crecen y se mezclan, con la lógica del collage posmoderno, casi todas las corrientes del pensamiento social de izquierda. El ALBA y los gobiernos que lo integran se encuentran en medio de una confrontación geopolítica e ideológica de escala continental que sesga enormemente la objetividad de los análisis. Este artículo pretende superar dichos sesgos presentando un análisis académico riguroso y sin toma de partido alguno. En él se analizan las circunstancias históricas que envuelven el nacimiento y evolución del ALBA y se incursiona en el análisis de su programa ideológico y sus proyectos concretos, señalando su convergencia con los del movimiento altermundialista latinoamericano y mundial. Por último, se apuntan algunas estadísticas de desarrollo concretas a fin de valorar los resultados en la práctica de las políticas económicas de este bloque regional.

  17. Velocidad de la onda de pulso y la excreción urinaria de albumina en pacientes hipertensos tratados con Perindopril Pulse wave velocity and urinary albumin excretion in hypertensive patients treated with perindopril

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    J. E. Tobilli

    2002-12-01

    Full Text Available La presión arterial sistólica, la presión arterial diastólica y la excreción urinaria de albúmina (EUA han sido reconocidas como predictores de riesgo cardiovascular. Además, los trastornos de la compliance arterial (CA evaluados mediante la velocidad de la onda de pulso elevada (VOP están estrechamente relacionados con los cambios de la presión arterial y correlacionados con la mortalidad cardiovascular y la presencia de ateroesclerosis. El objetivo primario de este estudio ha sido determinar la relación entre la VOP y la EUA en un grupo de pacientes no fumadores con hipertensión esencial y secundariamente evaluar los cambios producidos por un inhibidor de la enzima convertidora de angiotensina (perindopril sobre estas dos variables. En el estudio participaron setenta pacientes (33 hombres y 37 mujeres hipertensos no fumadores, sin tratamiento previo, de 50 ± 7 años (entre 35-69. La VOP de todos los pacientes fue estudiada por medio de un dispositivo computarizado (Complior en el período basal y a los seis meses de tratamiento con perindopril. También se determinó la EUA por el método de inmunodifusión radial al inicio del tratamiento y luego de seis meses de tratamiento con perindopril (4.6 ± 1.4 mg/día. Al finalizar el estudio se observó una reducción significativa de la presión arterial sistólica (PAS (160.2 ± 10.6 vs. 131.9 ± 7.1 mmHg, pSystolic and diastolic blood pressures and urinary albumin excretion (UAE have been recognized as predictors for cardiovascular risk. Furthermore, arterial compliance (AC disorders assessed by increased aortic pulse wave velocity (PWV are closely related to changes in blood pressure and strongly correlated with cardiovascular mortality and presence or extent of atherosclerosis. Our purpose in the present study was to determine a relationship between AC using PWV and UAE in a group of non-smoking patients with essential hypertension, and the level of interaction of ACE inhibition on

  18. Estimación de la conductividad hidráulica saturada in situ en un suelo tratado con vinaza Field satured hydraulic conductivity estimation on vinasse trated soil

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    Ludwig M Rojas D

    2008-06-01

    Full Text Available Se estimaron los cambios en la conductividad hidráulica saturada mediante las técnicas de caída de carga" y "fuente localizada de agua en un suelo Ustipsamment típico arenoso isohipertérmico con dosis diluidas de vinazas. La investigación se realizó en el centro experimental de la Universidad Nacional de Colombia Sede Palmira (3° 25'39.81" N y 76° 25'45.70" o, 953 m.s.n.m, 24 °C y 60% HR, 1.020 mm. Los dos métodos no difirieron de forma significativa (pChanges of the satured hydraulic conductivity in a soil was estimated using the “falling head” and “point source” methods. The soil treated with vinasse was an Ustipsamment Typic Sandy Isohipertermic located at the experimental center of the National University of Colombia at Palmira (3° 25' 39.81" N, 76° 25' 45.70" W; 953 m.a.s.l., 24 °C, 60% RH. and 1020 mm.. The field methods used did not show statistical differences for the estimation of the satured hydraulic conductivity (p<0.05. However, a decreasing exponential relationship between hydraulic conductivity and vinasse concentration was found. The hydraulic conductivity was reduced about of 50% from the initial value to 2° Brix in a sandy soil, 5.3° brix to a sandy loam soil and 6.1° Brix to a clay loam soil.

  19. Field satured hydraulic conductivity estimation on vinasse trated soil Estimación de la conductividad hidráulica saturada in situ en un suelo tratado con vinaza

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    Menjívar Flórez Juan Carlos

    2008-06-01

    Full Text Available Changes for soil satured hydraulic conductivity were estimated by using the “falling head” and “point source” methods. The soil type trated with vinasse was Ustipsamment Typic Sandy Isohipertermic located at Colombia National University experimental center (3° 25' 39.81"; N, 76° 25' 45.70"; W; 953 m.s.n.m., 24 °C, 60% HR. and 1020 mm.. The used field methods did not show statistical differences for the estimation of the satured hydraulic conductivity (p<0.05, however a decreasing exponential relationship between hydraulic conductivity and vinasse concentration was found. The hydraulic conductivity was reduced about of 50% from the initial value to 2° brix in sandy soil, 5.3° brix to sandy loam soil and 6.1° brix to clay loam.Key words: Point source method; Simulation models; Falling head method; Irrigation.Se estimaron los cambios en la conductividad hidráulica saturada mediante las técnicas de “caída de carga” y “fuente localizada de agua” en un suelo Ustipsamment típico arenoso isohipertérmico con dosis diluidas de vinazas. La investigación se realizó en la Universidad Nacional de Colombia Sede Palmira (3° 25'39.81"; N y 76° 25'45.70"; O, 953 m.s.n.m, 24 °C y 60% HR, 1.020 mm. Los dos métodos no difirieron de forma significativa (p<0.05 en la estimación de la conductividad hidráulica saturada promedio, la cual se redujo de forma exponencial al incrementar la concentración de vinaza. Los resultados obtenidos nos indican una reducción de la conductividad hidráulica del 50% para una concentración de vinaza de 2° Brix en un suelo arenoso, 5.3° Brix en el suelo franco arenoso y 6.1° Brix en el suelo franco arcilloso.tratados internacionales en América Latina

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    Víctor Bazán

    2006-01-01

    Full Text Available En este artículo el autor analiza las soluciones que, desde el plano de las respectivas normativas constitucionales, ofrece el derecho comparado de algunos países latinoamericanos en relación con la problemática del control de constitucionalidad de los tratados y convenios internacionales. En el trabajo se postula fundamentalmente que dicho contralor de constitucionalidad debe ser previo y obligatorio, en orden a prevenir contradicciones o disturbios normativos ad intra e intensificar, así, la búsqueda de la preservación de la supremacía constitucional; coadyuvar al mantenimiento de la coherencia y lógica del sistema de fuentes, y evitar la vinculación jurídica del Estado correspondiente en el ámbito internacional sin proceder, previamente, a las adecuaciones normativas pertinentes o, en su caso, a desistir de la aprobación del tratado o a concretarla con reservas, pues –entre diversos aspectos de la cuestión– la responsabilidad internacional del Estado está en juego.

  1. Fall-related injuries among youth under 20 years old who were treated in Nicaraguan emergency departments, 2004 Lesiones relacionadas con caídas en menores de 20 años de edad que fueron tratados en departamentos de emergencias de Nicaragua, 2004

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    María de Lourdes Martínez-Trujillo

    2011-04-01

    Full Text Available OBJECTIVE: To describe the circumstances of fall-related injuries among youth 0-19 years treated in emergency departments in Nicaragua; to estimate the incidence rates (IR of falls; and, to identify areas for prevention efforts. MATERIAL AND METHODS: All patients OBJETIVO: Describir las lesiones relacionadas con caídas entre los niños y adolescentes menores de 20 años de edad que fueron tratados en departamentos de emergencia de Nicaragua, 2004. Describir las circunstancias y estimar la tasa de incidencia (TI de las caídas entre niños y adolescentes de 0-19 años atendidos en las salas de emergencia en Nicaragua. Además, identificar áreas dónde dirigir los esfuerzos de prevención. MATERIALES Y MÉTODOS: Se seleccionaron todos los pacientes (6593 de 0-19 años lesionados por caídas atendidos en emergencia por el Sistema de Vigilancia de Lesiones en 2004 en las ciudades de Managua, León, Jinotepe y Ciudad Sandino. RESULTADOS: En 2004, la TI para caídas en niños y adolescentes 0-19 años fue 104.2 por 10000 habitantes. La TI en varones fue dos veces más alta que en mujeres. Los principales objetos involucrados fueron árboles (23.3% y camas (15.2%. La principal naturaleza de lesión fue fractura (35.7%. CONCLUSIONES: Mobiliario, lugares de recreación y ambiente físico fueron las áreas identificadas. Desarrollar intervenciones incluyendo cambios en el ambiente del hogar y áreas recreacionales, así como programas educacionales, resulta muy útil para adolescentes y cuidadores.

  2. UM TRATADO PARA O AMOR

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    Maria José Caldeira do Amaral

    2015-07-01

    Full Text Available No Tratado do Amor Cortês - Tractatus de Amore - André Capelão deseja oferecer ao leitor a arte cortês de amar, a beleza do desejo erótico e a disciplina da paixão constitutiva dessa arte que é amar. O maior argumento dessa obra é efetivar o suspiro fundo que a dimensão amorosa infunde na alma do homem e da mulher aos quais foi concedida a virtude. Para esse autor, escriba da chancelaria real e talvez, não se sabe com certeza, um Ordo Sacratus, o amor é a raiz de toda cortesia, a fonte de todo bem. Nosso objetivo, então, é encontrar nessa suma amorosa construída nos enlaces da Literatura de Cavalaria Medieval, os desdobramentos essenciais dessa vida afetiva bela e virtuosa no enredo profundo do qual emerge o afeto, a fé e a contradição da experiência humana do sofrimento amoroso. Palavras Chave: Literatura Medieval. Amor Cortês, André Capelão, virtude, desejo. Abstract: With the treaty toward the love - Tractatus de Amore – André Capelão offers to the reader the courteous’ art for love, the erotic desire’s beauty and the  suffering discipline belong this love’s art  is. The best reason of this literary composition is to achieve the depth sigh that the loving dimension infuses into the lovers’s soul, the man and the woman wich this virtue was conceded. For this author, the royal chancery scribe and perhaps, no one knows for sure, a Sacratus Ordo, love is the root of all free, the source of all good. Our goal, then, is to find this sum loving built in interlacing of Medieval Knights literature, the essential developments of this beautiful and virtuous love life in the deep storyline which emerges affection, faith and the contradiction of the human experience of love suffering. Key words: Medieval Literature. Courteous Love. André Capelão. Virtue.

  3. El Tratado De Dilectione Dei de Balduino de Ford

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    Carlos Hallet

    2004-01-01

    Full Text Available Figura relevante de la Orden del Císter, Balduino de Ford es un autor que se distingue por la originalidad de su espiritualidad. Su tratado De dilectione Dei es una meditación sobre el Primer Mandamiento, que nos invita a amar a Dios "con todo el corazón en sus beneficios, con toda el alma en sus promesas, con todas las fuerzas en sus juicios y con toda la mente en sus preceptos". Su reflexión, nutrida de la Biblia y expresada en un lenguaje marcado por la retórica latina, insiste en que el amor perfecto exige del creyente amar lo que a Dios le agrada porque a Él le agrada. Termina identificando prácticamente amor con obedienciaFamous figure of the cistercian order, Baldwin of Ford is an author who stands out for the originality of his spirituality. His treatise "De dilectione Dei" is a meditation about the First Comandment, which is an invitation to love God "with all the heart in His benefits, with all the soul in His promises, with all the forces in His judgements and with all the mind in His precepts". According to his reflection, fed with the Bible and expressed in a language marked by the latin rhetoric, the perfect love requires to love what is pleasing to God because it pleases Him. Baldwin practically identifies love with obedience

  4. Asociaciones verbales en esquizofrénicos tratados con olanzapina frente a los tratados con neurolépticos convencionales

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    Basilia Guerra Amador; María Pilar Jiménez Sánchez; José Luis Fernández Trespalacios; María del Prado Rivero Expósito

    2002-01-01

    En estudios anteriores se ha comprobado que los sujetos esquizofrénicos presentan mayor índice de comunalidad y mayor índice de respuestas únicas que los sujetos normales en el test de asociaciones verbales de Kent-Rosanoff. Estos resultados, interpretados como una mayor estereotipia y menor nivel de integración en el grupo, nos llevarían a poder delimitar un aspecto de anormalidad en el funcionamiento cognitivo de algunos pacientes esquizofrénicos. Por otra part...

  5. El tratado de Derecho Administrativo del Profesor Rodolfo Carlos Barra

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    Daniel Hugo Martins

    2014-06-01

    Full Text Available En el "Tratado" cuyos primeros dos tomos han sido públicados recientemente, Barra se propone aplicar la "tesis cuatripartita" al derecho administrativo, con base en la "filosofía perenne" y la interpretación tomista del derecho."Este trabajo -dice- propugna la sistematización y mediatización del Derecho Administrativo, como rama del derecho público que garantiza el cumplimiento del acto justo en las relaciones de justicia distributiva y está referido a la regulación de la relación jurídica Estado (Administración Pública - administrado"

  6. Malformación arteriovenosa pulmonar: Características clínicas, diagnóstico y rol del tratamiento quirúrgico en pacientes tratados con cirugía resectiva pulmonar Pulmonary arteriovenous malformation: Clinical features, diagnosis and role of surgical management in patients with lung resection surgery

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    ROBERTO GONZÁLEZ L

    2011-03-01

    Full Text Available Introducción: Las malformaciones arteriovenosas pulmonares (MAVP son infrecuentes y la cirugía tiene un rol en casos seleccionados. Objetivos: Describir las características clínicas, métodos diagnósticos y rol del tratamiento quirúrgico en pacientes tratados con cirugía por MAVP. Materialy Método: Revisión retrospectiva, incluyendo todos los pacientes con diagnóstico de MAVP en quienes se realizó cirugía en el Instituto Nacional del Tórax, desde febrero de 2005 a febrero de 2010. El seguimiento fue por control médico o contacto telefónico. Resultados: Se analizó 8 pacientes, seis mujeres (relación 3:1, edad entre 16 y 68 años. Los síntomas y signos más frecuentes fueron: disnea, cianosis y acropaquia. La localización más frecuente fue el lóbulo inferior derecho. Cuatro pacientes tenían MAVP múltiples y cuatro cumplían con criterios de Enfermedad de Rendu-Osler-Weber Seis tenían policitemia y dos anemia. La radiografía fue anormal en todos los casos y la tomogrqfía computada definió la anatomía en siete. Angiogrqfia se realizó en tres casos. Dos tenían ecocardiograma con contraste y cuatro cintigrama. La cirugía más frecuente fue la lobectomía. La indicación de cirugía fue: tamaño de la MAVP en cinco, falla de embolización en dos y hallazgo intra operatorio en uno, intervenido por otra razón. Uno presentó hemorragia post-operatoria. La estadía post-operatoria fue entre 2 y 10 días. No hubo mortalidad. En el último control todos los pacientes estaban asintomáticos. Conclusión: Las MAVPpueden presentarse en un amplio espectro clínico y anatómico. Pueden generar síntomas y complicaciones graves, por esto se recomienda tratarlas. El estudio pre-operatorio se basa en demostrar el shunt y en determinar las características anatómicas de la lesión. En algunos casos seleccionados está indicada la cirugía resectiva pulmonar.Background: Pulmonary arteriovenous malformations (PA VM are rare and surgery

  7. Posesión, retención y uso de mosquiteros tratados con insecticidas de larga duración luego de un año de su distribución en Loreto, Perú Long-lasting insecticide - treated bednet ownership, retention and usage one year after their distribution in Loreto, Peru

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    Angel Rosas-Aguirre

    2011-06-01

    Full Text Available Objetivos. Evaluar la posesión, retención y uso de mosquiteros tratados con insecticida de larga duración (MTILD luego de un año de su distribución en Loreto, Perú. Materiales y métodos. De julio a septiembre de 2007 se distribuyeron 26 185 MTILD Olyset Net® en 194 comunidades objetivo de Loreto, que protegieron a 45 331 personas. Posteriormente, se realizaron visitas de monitoreo (primera en diciembre de 2007 y segunda en julio de 2008 a los hogares de una muestra de 60 comunidades objetivo (30,9% del total, colectándose mediante un cuestionario semiestructurado los datos necesarios para el cálculo de indicadores de posesión, retención y uso de los MTILD. Resultados. En ambas visitas, la posesión de MTILD en hogares fue elevada (99,9% y 98,7%, respectivamente. La razón MTILD/persona disminuyó de 0,58 al momento de la distribución a 0,51 en la segunda visita, estimándose una retención al año de MTILD de 87%. En la primera visita, 99,0% de los niños Objectives. To assess long-lasting insecticide - treated bednet (LLITN ownership, retention and usage one year after their distribution in Loreto, Peru. Materials and methods. From July to September 2007, 26,185 LLITNs Olyset Net ® were delivered in 194 targeted communities in the Peruvian Amazon region, covering 45,331 people. Two cross-sectional community-based surveys in December 2007 and July 2008 were undertaken in a sample of 60 targeted communities (30.9% out of the total. A semi-structured questionnaire was used to collect necessary data to calculate LLITN ownership, retention and usage indicators. Results. High LLITN household ownership was showed in both surveys (99.9% and 98.7%, respectively. LLITN/ person ratio decreased from 0.58 at the end of the LLITN delivery to 0.51 in the second survey, estimating LLITN retention of 87% after 1 year of intervention. In the first survey, 99.0% of all children <5 years and 96,0% of pregnant women slept under a LLITN the previous

  8. Patterns of extension of gastrointestinal stromal tumors (GIST treated with imatinib (Gleevec® by 18F-FDG PET/CT Patrones de extensión de los tumores del estroma gastrointestinal (GIST tratados con imatinib (Gleevec® mediante PET/TC con 18F-FDG

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    Eulalia Valls-Ferrusola

    2012-07-01

    Full Text Available Background and aim: currently it is recognized the usefulness of 18F-FDG PET in assessing response to therapy with imatinib (Gleevec® in the gastrointestinal tract sarcomas (GIST. To facilitate the follow-up of these studies is important to know the patterns of metastatic spread. The aim of this paper is to describe patterns observed in the 18F-FDG PET/CT. Method: retrospective study included 29 patients who underwent 18F-FDG PET/CT after being diagnosed with unresectable or metastatic GIST. In total, 87 PET/CT studies were performed (1-6 controls per patient with a mean time of follow-up 6-36 months. We analyzed the location of the lesions evidenced in PET, CT and fusion. Images were evaluated visually and semiquantitatively (SUV. In cases in which has been considered necessary, additional images have been undertaken: PET delayed imaging, intravenous contrast CT and inspiratory chest CT. Results: the most common primary site was the stomach (41%, small bowel (35%, and rectum (24%. Significant changes in the location of metastatic disease between pre-treatment and the monitoring were observed, with the appearance of more extra-abdominal disease. Conclusions: individualization of protocol studies and interpretation of PET, CT and fused images were required for evaluation of treatment response to imatinib. Hybrid 18F-FDG PET/CT provides an accurate determination of the extent of GIST. While the most common metastatic site is the liver and peritoneum, in the following cases are common extra-abdominal disease.Introducción y objetivo: actualmente está reconocida la utilidad de la 18F-FDG-PET en la evaluación de la respuesta a la terapia con imatinib (Gleevec® en los sarcomas del tracto gastrointestinal (GIST. Para facilitar la valoración comparativa de estos estudios es importante conocer sus patrones de diseminación metastásica. El objetivo de este trabajo es describir estos patrones evidenciados en la 18F-FDG-PET/TC. Método: estudio

  9. Control Sitophilus zeamais (Coleoptera: Curculionidae in Maize (Zea mays L. treated with diatomaceous eart Coltrol de Sitophilus zeamais (Coleoptera: Curculionidae en maíz (Zea mays L. tratados con tierra de diatomeas Controle de Sitophilus zeamais (Coleoptera: Curculionidae em milho (Zea mays L. tratado com terra de diatomácea

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    Juliana Neitzke

    2010-04-01

    ácea (TD, na proporção de zero, 50, 100, 150, 200, 250 g de TD t-1, todos acondicionados em copos de plástico de 250 mL. Em cada copo plástico foram liberados 20 insetos de S. zeamais e estes fechados com tecido de “nylon” de malha fina, para a aeração. As avaliações da mortalidade dos insetos foram realizadas aos 3, 6 e 9 dias após a infestação (DAI, através da contagem em bandejas dos insetos mortos e vivos, e da possível reinfestação. O tratamento com terra diatomácea em milho (Zea mays na dosagem de 250 g t-1 proporcionou melhor controle de S. zeamais.

    El maíz (Zea mays L. es uno de los cereales más importantes cultivadas en todo el mundo. Como el producto se vende al natural, la principal preocupación es mantener la calidad del grano, pero su almacenamiento es difícil debido a la amplia gama de plagas que pueden atacar, causando reducción de calidad. El objetivo de este estudio fue evaluar diferentes dosis de tierra de diatomeas (TD en la mortalidad del gorgojo del maíz (Sitophilus zeamais en granos del maíz almacenado y comprobar el tiempo de exposición de cada tratamiento. El diseño experimental fue completamente aleatorizado con seis tratamientos y cinco repeticiones. Los tratamientos consistieron en aumentos en las dosis de TD en una proporción de cero, 50, 100, 150, 200, 250 g de TD t-1, todo ello incluido en vasos de plástico de 250 mL. En cada vaso de plástico fue puesto en libertad 20 insectos de S. zeamais y cerrada con malla de tela fina de nylon para la aireación. Las evaluaciones de la mortalidad de insectos se realizaron los días 3, 6 y 9 después de la infestación (DAI, con la cuenta en las bandejas de insectos vivos y muertos, y de la reinfestación posible. El tratamiento con tierra de

  10. Neoliberalismo y Tratado de Libre Comercio: ¿hacia ciclos de guerra civil?

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    John Saxe-Fernández

    1999-12-01

    Full Text Available El tratado de libre comercio TLC, es la formalización de una relación subordinada de México con Estados Unidos. El aperturismo mexicano ha sido marcado con mayor énfasis por los gobiernos de Porfirio Díaz y de Carlos Salinas de Gortari. El modelo económico derivado ha provocado la desviación de inversión pública al gasto no productivo, como el pago del servicio de la deuda, la liberación de precios junto al control salarial para reducir la inflación, con el propósito de "aumentar competitividad internacional" de los productos mexicanos de exportación.

  11. Constitución, Tratado de Libre Comercio Andino – Estados Unidos, Comunidad Andina

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    Marcel Tangarife Torres

    2007-12-01

    Full Text Available El presente escrito pretende hacer algunas reflexiones acerca de las relaciones jurídicas existentes entre la Constitución Política, el Tratado de Libre Comercio con Estados Unidos (TLC, y el ordenamiento jurídico de la comunidad andina. En esta oportunidad se recogerán algunos planteamientos hechos por el autor en publicaciones anteriores, con las actualizaciones, ampliaciones y precisiones que surgen de un proceso tan dinámico como el de la internacionalización de las relaciones económicas y comerciales. el autor pide excusas por citar algunos trabajos suyos, pues existe un gran vacío de doctrina especializada sobre la materia, vacío que ojalá sea llenado con prontitud.

  12. Tratamiento y seguimiento en pacientes con leucemia mieloide crónica en el hemocentro - UNICAMP (Brasil

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    E. Miranda

    2006-04-01

    Full Text Available Relatar la experiencia del Hemocentro Unicamp en el tratamiento y seguimiento de los pacientes con leucemia mieloide crónica (LMC tratados con mesilato de imatinib y la experiencia en transplantes alogénico.

  13. Tratamiento y seguimiento en pacientes con leucemia mieloide crónica en el hemocentro - UNICAMP (Brasil)

    OpenAIRE

    Miranda, E.; M. Torresan Delamain; I. Lorand Metze; A. C. Vigorito; K. B. Pagnano; Souza, C.A.

    2006-01-01

    Relatar la experiencia del Hemocentro Unicamp en el tratamiento y seguimiento de los pacientes con leucemia mieloide crónica (LMC) tratados con mesilato de imatinib y la experiencia en transplantes alogénico.

  14. Efectos de las formulaciones de citronelal ozonizado en el tratamiento de conejos con Dermatomicosis

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    Kendra García Madan

    2010-01-01

    Full Text Available El citronelal ozonizado presenta propiedades antimicrobianas y antifúngicas contra diferentes microorganismos. El objetivo de este estudio fue investigar el efecto de tres formulaciones, al 1, 3 y 5% de citronelal ozonizado y una formulación placebo, comparadas con el OLEOZON Tópico en la Dermatomicosis de conejos. En este estudio se utilizaron 27 conejos blancos de la raza Nueva Zelanda, distribuidos en 6 grupos de la siguiente forma: Grupo I, conejos sin tratamiento; Grupo II, tratados con OLEOZON Tópico; Grupo III, tratados con la formulación 1 (citronelal ozonizado al 3%; Grupo IV, tratados con la formulación 2 (citronelal puro al 5%; Grupo V, tratados con la formulación 3 (citronelal ozonizado al 5% y Grupo VI, tratados con la formulación 4 (citronelal ozonizado al 1%. El diagnóstico de la enfermedad se realizó por inspección visual y raspado profundo y cultivo. Todos los tratamientos se aplicaron tópicamente en días alternos durante 15 días. Como resultado, los animales de los grupos II Y III se curaron en los 15 días, Sin embargo los conejos del grupo II mostraron la piel aceitosa por una semana después de concluido el estudio. La apariencia de la piel sana de los conejos tratados con la formulación al 3% fue mejor en comparación con el grupo tratado con OLEOZON. El resto de los grupos, tratados con las formulaciones al 1 y 3% y con la formulación placebo, no se curaron con los 15 días de tratamiento. Este estudio demuestra la alta efectividad terapéutica de la formulación de citronelal ozonizado al 3% en el tratamiento de la dermatomicosis en conejos.

  15. La Política Criminal de los Tratados Internacionales

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    Jean Pierre Matus A

    2007-01-01

    Full Text Available El artículo expone las principales características comunes de los "delitos de trascendencia internacional" (international crimes contemplados en tratados y convenciones, que no constituyen "crímenes de derecho internacional" (crimes under international law, presentando un rudimiento de sistematización de su parte general, en el sentido de la dogmática continental. Se sostiene que los hechos comprendidos en tales categorías, que en general afectan la libertad, la vida y la seguridad personal, se reconocen como delictivos por un amplio número de Estados, lo que podría ser indicador de la existencia de un incipiente "Estado mundial", con reglas comunes de penalización al mismo tiempo necesitadas de implementación por parte de los Estados e independientes de la existencia de un órgano supranacional para hacerlas efectivasThis article exposes the principal characteristics that are common to the international crimes contemplated in treaties and conventions which do not constitute "crimes under international law", presenting a rudiment of systematization of its general part in the sense of the continental dogmatic. It is sustained that the facts understood in these categories, which in general affects the liberty, the life, and the personal security considered as crimes by a wide number of States which could be an indicator of the existence of an incipient "world state", with common rules of penalization at the same time needed to implement by the states and independents of the existence of an supranational organ to make these effective

  16. Introducción. El compromiso con los derechos fundamentales.

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    Mangas, Araceli

    2016-01-01

    Se analiza el carácter y la evolución de la protección de los derechos fundamentales en la UE, desde el silencio de los Tratados fundacionales, la protección judicial y la inclusión de la obligación en lso Tratados y en la Carta de Niza, las tensiones con las cortes constitucionales de los Estados miembros y la situación de plena protección tras el Tratado de Lisboa.

  17. Introducción. El compromiso con los derechos fundamentales.

    OpenAIRE

    Mangas, Araceli

    2008-01-01

    Se analiza el carácter y la evolución de la protección de los derechos fundamentales en la UE, desde el silencio de los Tratados fundacionales, la protección judicial y la inclusión de la obligación en lso Tratados y en la Carta de Niza, las tensiones con las cortes constitucionales de los Estados miembros y la situación de plena protección tras el Tratado de Lisboa.

  18. Esquistossomose: 1.000 pacientes tratados

    Directory of Open Access Journals (Sweden)

    Pedro Aquino Noleto

    1974-12-01

    Full Text Available Os autores relatam sua experiência com o hycanthone em 1.000 pacientes de esquistossomose mansônica, até agora tratados no Hospital de Clínicas da Universidade do Estado da Guanabara. São pacientes oriundos de áreas endêmicas do País, especialmente do nordeste e sudeste, 53,9% do sexo masculino e 46,1% do sexo feminino, de idade entre 5 e 63 anos. A forma clínica predominante da parasitose foi a hépato-intestinal (96,8%. O medicamento foi administrado em dose única, na razão de 3 mg/kg de peso corporal, a 33.6% de pacientes internados e a 66 4% em regime de tratamento ambulatorial. Os níveis séricos das transaminases, determinados, para confronto, antes e depois do uso do produto, em 60 dos pacientes internados, não se alteraram, ou apenas sofreram elevações inexpressivas. Não houve efeitos colateriais em 42,3% dos pacientes. Nos demais, esses efeitos foram de pequena e média intentidade, duraram apenas o 19 dia, na maioria das vezes, e consisfram, especialmente, de náuseas e de vômitos. O controle de cura parasitária estabelecido compreendeu 4 exames de fezes - aos 30, 60, 90 e 120 dias do emprego do medicamento, o que já se fez em 330 pacientes (33%, com 99% de cura. Incluída a biópsia retal, sempre que foi possivel, por ocasião do 4º exame de fezes, o esquema funcionou até agora em 97 pacientes (9,7%, dos quais 92 (94% estão curados, segundo esse critério. O presente trabalho confirma a ação esquistossomicida do hycanthone, bem como sua boa tolerabilidade, inclusive no que se refere ao hepatócito. Os doentes, entretanto, devem ser criteriosamente selecionados, tendo-se em vista as contra-indicações conhecidas, de modo especial em relação ao fígado.

  19. Replicación viral y producción de óxido nítrico y malondialdehído en cultivos celulares y ratones tratados preventivamente con melatonina, minociclina y ácido ascórbico infectados por el virus de encefalitis equina venezolana

    OpenAIRE

    Salazar de Acosta, Jenny

    2011-01-01

    El virus de Encefalitis Equina Venezolana (EEV) ha causado extensas epidemias a lo largo de América del Sur, sobre todo en Venezuela. Afecta, con una alta morbilidad, el sistema nervioso central (SNC) en humanos y equinos. Existen sustancias antioxidantes que interactúan con los radicales libres retardando la oxidación; entre ellas se encuentran la Melatonina (MLT), la Minociclina (MIN) y el Ácido ascórbico (AA). Se plantea determinar el efecto in vitro e in vivo de la MLT, MIN y AA sobre la ...

  20. Estudio del perfil del paciente tratado en la asignatura de prótesis estomatológica II en la Facultad de Odontología de Sevilla durante el período 2001-2011 y su relación con las competencias del título de graduado en odontología.

    OpenAIRE

    Arroyo Cruz, Gema

    2014-01-01

    Con esta breve introducción me gustaría transmitir cómo surgió en mí la inquietud por este trabajo. Toda mi vida universitaria ha estado ligada a la disciplina de Prótesis, primero como alumna interna, después como colaboradora y finalmente como docente. Esto me ha permitido estar presente y conocer de primera mano cómo se ha ido impartiendo la asignatura, qué cambios han acontecido y formarme con ello una opinión al respecto. Pero observar no siempre nos permite obtener una información preci...

  1. Characterization and Fine Mapping of a Novel Rice Albino Mutant low temperature albino 1

    Institute of Scientific and Technical Information of China (English)

    Yu Peng; Sheng Teng; Yi Zhang; Jun Lv; Jianhui Zhang; Ping Li; Xiaoliang Shi; Yufeng Wang; Honglei Zhang; Zuhua He

    2012-01-01

    Albino mutants are useful genetic resource for studying chlorophyll biosynthesis and chloroplast development and cloning genes involved in these processes in plants.Here we report a novel rice mutant low temperature albino I (ltal) that showed albino leaves before 4-leaf stage when grown under temperature lower than 20℃,but developed normal green leaves under temperature higher than 24℃ or similar morphological phenotypes in dark as did the wild-type (WT).Our analysis showed that the contents of chlorophylls and chlorophyll precursors were remarkably decreased in the ltal mutant under low temperature compared to WT.Transmission electron microscope observation revealed that chloroplasts were defectively developed in the albino ltal leaves,which lacked of well-stacked granum and contained less stroma lamellae.These results suggested that the ltal mutation may delay the light-induced thylakoid assembly under low temperature.Genetic analysis indicated that the albino phenotype was controlled by a single recessive locus.Through map-based approach,we finally located the Ltal gene to a region of 40.3 kb on the short arm of chromosome 11.There are 8 predicted open reading frames (ORFs) in this region and two of them were deleted in ltal genome compared with the WT genome.The further characterization of the Ltal gene would provide a good approach to uncover the novel molecular mechanisms involved in chloroplast development under low temperature stress.

  2. Los tratados de libre comercio: instrumentos para controlar la biodiversidad

    OpenAIRE

    Rodríguez Cervantes, Silvia

    2013-01-01

    La soberanía de cada Estado para regular la Bioprospección y utilización de la biodiversidad contenida en sus fronteras, fue un derecho reforzado por el Convenio de Diversidad Biológica de 1994 y diez años más tarde por el Tratado conocido como Tratado de la Semilla. Sin embargo, sus alcances se han visto obstaculizados por diversos pactos comerciales y sus respectivas políticas de propiedad intelectual. Algunos son de carácter multilateral; otros son re...

  3. Evaluación tomográfica y radiográfica de la obturación radicular tridimensional de conductos radiculares únicos tratados con tres técnicas de obturación radicular: Estudio in Vitro

    Directory of Open Access Journals (Sweden)

    Mónica Alexandra Pavón Granja

    2016-09-01

    Full Text Available El principal reto durante la terapia endodóntica es la obturación radicular, considerada como fase crítica ya que de esta va a depender el éxito o el fracaso. Por varios años se ha investigado tanto materiales como técnicas que permitan el sellado hermético tridimensional del sistema de conductos radiculares, biocompatibilidad que permita la adecuada reparación de los tejidos periapicales y que la obturación se mantenga con el tiempo proporcionando salud. Objetivo: Evaluar la adaptación tridimensional de tres técnicas de obturación radicular definitiva a nivel del tercio apical de conductos radiculares únicos. Materiales y métodos: Estudio de tipo experimental y aleatorizado, la muestra fue de 42 raíces de dientes uniradiculares divididos en 3 grupos de estudio (n=14, previamente se realizó un registro radiográfico periapical digital de toda la muestra posteriormente fueron instrumentados con técnica hibrida, desinfectados con NaOCl al 5,25% + activación ultrasónica y EDTA al 17%, GA fue sometido a técnica de obturación lateral en frío, GB aplicado técnica de obturación termomecánica McSpadden y GC se obturó con técnica termoplastificada (BeFill-VDW. Resultados: Los grupos C y B observados a través de tomografía computarizada presentaron mejores resultados de obturación radicular que el grupo A que no presentó un buen sellado apical, sin embargo, en el grupo C se observó mejores resultados que en A y B Conclusiones: Las técnicas de obturación radicular definitivas con la técnica termoplastificada mostraron ser ideales para proporcionar un sellado apical hermético durante el tratamiento endodóntico en la fase de obturación

  4. Esquistossomose: 1.000 pacientes tratados

    Directory of Open Access Journals (Sweden)

    Pedro Aquino Noleto

    1974-12-01

    Full Text Available Os autores relatam sua experiência com o hycanthone em 1.000 pacientes de esquistossomose mansônica, até agora tratados no Hospital de Clínicas da Universidade do Estado da Guanabara. São pacientes oriundos de áreas endêmicas do País, especialmente do nordeste e sudeste, 53,9% do sexo masculino e 46,1% do sexo feminino, de idade entre 5 e 63 anos. A forma clínica predominante da parasitose foi a hépato-intestinal (96,8%. O medicamento foi administrado em dose única, na razão de 3 mg/kg de peso corporal, a 33.6% de pacientes internados e a 66 4% em regime de tratamento ambulatorial. Os níveis séricos das transaminases, determinados, para confronto, antes e depois do uso do produto, em 60 dos pacientes internados, não se alteraram, ou apenas sofreram elevações inexpressivas. Não houve efeitos colateriais em 42,3% dos pacientes. Nos demais, esses efeitos foram de pequena e média intentidade, duraram apenas o 19 dia, na maioria das vezes, e consisfram, especialmente, de náuseas e de vômitos. O controle de cura parasitária estabelecido compreendeu 4 exames de fezes - aos 30, 60, 90 e 120 dias do emprego do medicamento, o que já se fez em 330 pacientes (33%, com 99% de cura. Incluída a biópsia retal, sempre que foi possivel, por ocasião do 4º exame de fezes, o esquema funcionou até agora em 97 pacientes (9,7%, dos quais 92 (94% estão curados, segundo esse critério. O presente trabalho confirma a ação esquistossomicida do hycanthone, bem como sua boa tolerabilidade, inclusive no que se refere ao hepatócito. Os doentes, entretanto, devem ser criteriosamente selecionados, tendo-se em vista as contra-indicações conhecidas, de modo especial em relação ao fígado.The authors report hier experiment with Hycanthone in a thousand patients suffering from schistosomiaasti mansoni, who have been treated in the Clinical Hospital of Guanabara University so far. The patients come from the endemical areas of the country, specially

  5. Análisis comparativo de pacientes con estenosis degenerativa lumbar pura (EDLP y estenosis secundaria a espondilolistesis degenerativa lumbar (ELDL tratados quirúrgicamente en el período de 2008 a 2011 en el Hospital Metropolitano de Quito-Ecuador Análise comparativa de pacientes com estenose degenerativa pura lombar (EDPL e estenose secundária a espondilolistese lombar degenerativa lombar (ELDL tratados cirurgicamente no período de 2008 a 2011 no Hospital Metropolitano de Quito, Equador Comparative analysis in patients with pure degenerative lumbar stenosis (EDLP and stenosis secundary to degenerative lumbar spondilolisthesis (ELDL surgically treated between 2008-2011 at the Hospital Metropolitano, Quito, Ecuador

    Directory of Open Access Journals (Sweden)

    Jaime Moyano

    2012-06-01

    Full Text Available OBJETIVO: Establecer si existen diferencias demográficas, de tratamiento y en resultados entre los grupos de EDLP y ELDL. MÉTODOS: Estudio retrospectivo observacional de 76 pacientes con EDL tratados quirúrgicamente. Se analizan por separado los datos demográficos y la evolución del grupo 1 (EDLP, 53 pacientes y del grupo 2 (ELDL, 23 pacientes. RESULTADOS: Grupo 1: 51% mujeres y 49% varones. Edad promedio 56,8 años. Evolución preoperatoria 34 meses; Grupo 2: 78% de mujeres y 22% de varones. Edad promedio 63,4 años. Evolución preoperatoria 10 meses. Los dos grupos fueron intervenidos con la misma técnica, por el mismo equipo quirúrgico. El porcentaje de satisfacción postoperatoria fue mejor para el grupo 1 cuando el tiempo de evolución preoperatoria fue menor a 18 meses. En el grupo 2 los hallazgos no fueron significativos. CONCLUSIÓN: La estenosis por ELDL tiene características de edad y sexo muy diferentes dela EDLP. La cirugía precoz presentó un mayor porcentaje de satisfacción.OBJETIVO: Determinar se existem diferenças demográficas, de tratamento e nos resultados entre os grupos EDLP e ELDL. MÉTODOS: Estudo observacional retrospectivo de 76 pacientes com EDLP tratados cirurgicamente. Analisamos separadamente os dados demográficos e os resultados do grupo 1 (EDLP, 53 pacientes e do grupo 2 (ELDL, 23 pacientes. RESULTADOS: Grupo 1: 51% mulheres e 49% homens; média de idade, 56,8 anos. Evolução pré-operatória, 34 meses. Grupo 2: 78% mulheres e 22% homens; média de idade, 63,4 anos. Evolução pré-operatória, 10 meses. Os dois grupos foram operados com a mesma técnica e pela mesma equipe cirúrgica. A porcentagem de satisfação pós-operatória foi maior no Grupo 1 quando a evolução pré-operatória foi inferior a 18 meses. No Grupo 2, os resultados não foram significativos. CONCLUSÃO: Na estenose secundária a ELDL, a idade e distribução por gênero foram muito diferentes do encontrado na EDLP. A cirurgia

  6. LOS TRATADOS INTERNACIONALES SOBRE DERECHOS HUMANOS Y SU UBICACIÓN EN EL ORDEN NORMATIVO INTERNO

    Directory of Open Access Journals (Sweden)

    Emilio Pfeffer Urquiaga

    2003-01-01

    Full Text Available El artículo analiza la precariedad de la normativa constitucional chilena en materia de incorporación del derecho convencional internacional, tanto en común como específicamente en materia de derechos humanos, pronunciándose sobre la jerarquía de los tratados que contienen derechos humanos de acuerdo con la doctrina y la jurisprudencia, abogando por un pronto desarrollo de normas constitucionales al efecto.This work highlights the precariousness of Chilean Constitutional Law with respect to the incorporation of international conventional Law, both in general and specifically in the area of human rights. The status accorded to human rights treaties by legal scholarship and judicial decisions is examined, and advocacy is advanced for further development of constitutional norms on the matter of incorporation of international treaties on human rights.

  7. Vinos, carnes, ferrocarriles y el Tratado de Libre Comercio entre Argentina y Chile (1905-1910

    Directory of Open Access Journals (Sweden)

    Pablo Lacoste

    2004-06-01

    Full Text Available Entre 1905 y 1910 Chile y Argentina negociaron la firma de un Tratado de Comercio con vistas a suprimir los aranceles aduaneros y consagrar el principio de "Cordillera Libre". El centro de atracción eran las exportaciones de ganado argentino a Chile y de vino chileno a Argentina. Pero en ambos países se produjo una fuerte reacción de los intereses creados con vistas a frustrar las tratativas diplomáticas. Tanto la Sociedad Nacional de Agricultura (Chile como el Centro Vitivinícola Nacional (Argentina realizaron intensas gestiones para alcanzar sus objetivos; esta última corporación llegó a movilizar miles de personas para oponerse al tratado; y hasta solicitó ayuda a los ferrocarriles británicos para que obstaculizaran el ingreso de los vinos chilenos al mercado argentino. La intensa resistencia de estas corporaciones terminaron por frustrar el proyecto, el cual fue definitivamente archivado en 1911.Between 1905 and 1910, Chile and Argentina negotiated the signature of a Trade Agreement in order to abolish the customs duties and consecrate the principle of "Free Mountain Range". The centre of attraction was the exports of Argentinean cattle to Chile and of Chilean wine to Argentina. But in both countries there aroused a strong reaction of the vested interests, purposely to thwart the diplomatic negotiations. Both, the Sociedad Nacional de Agricultura (Chile as well as the Centro Vitivinícola Nacional (Argentina carried out intense negotiations to reach their objectives; the latter even movilized thousands of people to oppose the treaty and went as far as requesting the help of the British railroads to block the entrance of Chilean wines to the Argentinean market. The stiff opposition of these corporations finally frustrated the project, which was definitively filed away in 1911.

  8. Fracturas por fatiga del cuello femoral: A propósito de un caso tratado quirúrgicamente

    OpenAIRE

    Arenas Planelles, Antonio; Arias Nieto, C.; Eslava Echavarren, E.; Tejero Ibáñez, Alberto; Garbayo Marturet, Antonio Jesús; Pablos Fernández, Julio de

    2000-01-01

    Se presenta un caso de fractura por fatiga de cuello femoral en un paciente de 26 años. Fue tratado quirúrgicamente realizándose osteosíntesis con 3 tornillos. La evolución fue satisfactoria, encontrándose el paciente sin dolor ni repercusión funcional a los 4 años de la lesión. A case of stress fracture of the femoral neck in a 26-year-old patient is presented. Surgical treatment was indicated by means of internal fixation with three screws. At four-year follow-up there was no pain or fun...

  9. Los tratados silogísticos de Boecio: sus fuentes, historia e influencia en la cristiandad latina

    Directory of Open Access Journals (Sweden)

    Manuel Correia

    2007-01-01

    Full Text Available En este artículo se describen los contenidos de un tratado sobre lógica aristotélica escrito por Boecio en el VI d. C, llamado por nuestras ediciones modernas De syllogismo categórico (=DSC. A través de sus contenidos, es posible mostrar: (i la importancia de este tratado en el proceso de transmisión de la lógica de Aristóteles al medioevo latino; (ii su relación con otro tratado monográfico similar, titulado por la crítica moderna Introductio ad syllogismos categóricos (ISC y su relación temática con DSC; (iii las fuentes más probables de ambos tratados; y, finalmente, (iv su influencia en el medioevo latino. La hipótesis que se defiende en este artículo es que los contenidos lógicos de este tratado, en particular la clasificación de las proposiciones categóricas, contenida en el corazón del DSC, entregan no solo el objeto temático al tratado, sino también coherencia argumentativa y unidad. En especial, el estudio de esta clasificación permite demostrar la unidad de DSC y en particular que el segundo libro de DSC es genuino y no espurio como sostuvieron, no hace mucho, los estudiosos Murari y McKinlay; además, esta misma clasificación permite apreciar su diferencia con ISC, por el hecho de que este último tratado posee una clasificación diferente a la de DSC. La base de la hipótesis propuesta se halla en que la clasificación mencionada es un intento por generar, a partir de los elementos preposicionales, las principales operaciones lógicas definidas por Aristóteles en sus escritos lógicos, asunto que en la revisión de De Rijk (1964 no quedó totalmente establecidoIn this article, the author describes the contents of a treatise on Aristotelian logic, written by Boethius in the sixth century A.D., titled in our modern editions as De syllogismo categórico (DSC. It is possible to show, through the contents: (i the importance of this treatise for the transmission process of Aristotle's logic to the Latin medieval

  10. How does agonistic behaviour differ in albino and pigmented fish?

    Science.gov (United States)

    Horký, Pavel; Wackermannová, Marie

    2016-01-01

    In addition to hypopigmentation of the skin and red iris colouration, albino animals also display distinct physiological and behavioural alterations. However, information on the social interactions of albino animals is rare and has mostly been limited to specially bred strains of albino rodents and animals from unique environments in caves. Differentiating between the effects of albinism and domestication on behaviour in rodents can be difficult, and social behaviour in cave fish changes according to species-specific adaptations to conditions of permanent darkness. The agonistic behaviours of albino offspring of pigmented parents have yet to be described. In this study, we observed agonistic behaviour in albino and pigmented juvenile Silurus glanis catfish. We found that the total number of aggressive interactions was lower in albinos than in pigmented catfish. The distance between conspecifics was also analysed, and albinos showed a tendency towards greater separation from their same-coloured conspecifics compared with pigmented catfish. These results demonstrate that albinism can be associated with lower aggressiveness and with reduced shoaling behaviour preference, as demonstrated by a tendency towards greater separation of albinos from conspecifics. PMID:27114883

  11. Expresión de cd34 en los blastos leucémicos como marcador pronóstico para muerte, recaída o falla de tratamiento en relación con la morfología monocítica de la leucemia mieloblástica aguda en pacientes tratados con quimioterapia “7x3” E HiDAC

    OpenAIRE

    Cárdenas Rodríguez, Yhonny Roberto

    2010-01-01

    Diferentes estudios in vitro y algunos escasos estudios clínicos han demostrado asociación entre la expresión de CD34 y resistencia a la apoptosis y múltiples medicamentos de quimioterapia, por lo que se hace muy importante la exploración clínica de esta variable como factor pronóstico en pacientes con Leucemia Mieloblástica Aguda y su posible modificación de efecto por parte de la morfología monocítica de algunas variedades de la enfermedad que tienen baja expresión conocida de CD34 (M5a y M...

  12. Los tratados internacionales como base de la diplomacia mundial.

    Directory of Open Access Journals (Sweden)

    Larys Leiba Hernández Villalobos

    2004-01-01

    Full Text Available Se presenta un análisis sobre las generalidades de los tratados internacionales: regulación jurídica, clasificación, estructura e innovaciones contempladas en la Constitución de la República Bolivariana de Venezuela (CRBV. Las fuentes documentales utilizadas se en marcan dentro del ámbito constitucional, legal y doctrinal. Se concluye que los tratados internacionales constituyen en la era actual, sin lugar a dudas, la «base de la diplomacia mundial», puesto que ayudan a que una sociedad globalizada marcada por intereses contrapuestos en el ámbito económico, político, religioso, militar, cultural, entre otros, pueda convivir conforme a un orden internacional establecido. Además, estos acuerdos contribuyen a lograr el mantenimiento de la paz, el orden público y la re;olución de conflictos internacionales.

  13. Influencia del marco regulatorio de los productos farmacéuticos en la salud pública. Análisis a partir de la ratificación por Colombia del Convenio ADPIC y de los Tratados de Libre Comercio con los Estados Unidos y la Unión Europea

    Directory of Open Access Journals (Sweden)

    Fernando Jiménez Valderrama

    2013-01-01

    Full Text Available Este artículo tiene por objetivo estudiar la relación entre la disponibilidad, los precios de los medicamentos y los intereses de salud pública. Para ello hemos utilizado una metodología de análisis de los intereses económicos implicados y también un método sistemático de tratamiento de la legislación nacional, comunitaria andina e internacional vigente. Igualmente hemos acudido a metodologías de derecho comparado entre nuestro ordenamiento jurídico nacional con los de otros países de mundo occidental. Existe un estrecho vínculo entre la disponibilidad y los precios de los medicamentos y los intereses de salud pública. Nuestro actual sistema legal reconoce a los inventores de nuevos medicamentos como un “monopolio” para negociar en el mercado farmacéutico. Para proteger los intereses públicos nuestra regulación establece algunos límites a los derechos de los inventores. Los derechos de propiedad se limitan en el tiempo y bajo algunas circunstancias es obligatorio autorizar a otros a usar la patente bajo un contrato de licenciamiento. La Organización Mundial del Comercio ha establecido (Decisión del Consejo de la OMC, Ronda Doha 2003 otros límites a estos derechos en caso de condiciones excepcionales. Nuestra Constitución Nacional otorga prevalencia a los intereses públicos sobre los privados. Es un deber de los gobiernos establecer un sistema justo en el cual los inventores puedan obtener una recompensa económica por sus creaciones y la sociedad pueda satisfacer sus necesidades de salud.

  14. Pretextos y contextos olvidados : arte, ciencia y técnica en algunos tratados contables de la Inglaterra Tudor

    Directory of Open Access Journals (Sweden)

    Juan Lanero Fernández

    2009-06-01

    Full Text Available El presente estudio pretende ver, desde una perspectiva amplia, los dos tratados de James Peele (1553, 1569. The pathe waye (1569, en su conjunto, se aparta de forma considerable de los tratados publicados con anterioridad; y por lo que se refiere a su primer libro (1553, dispone de suficientes rasgos diferenciadores para que en el todo y en las partes sea una pieza bien distinta de tratados anteriores. Algunos detalles de The maner and fourme provienen directamente de Pacioli o a través del primer tratado inglés de partida doble, obra de Hugh Oldcastle (1543, o de Ympyn. La influencia de éste, por su tratado holandés/francés (1543 y la traducción inglesa (1547, se aprecia en The pathe waye en el cierre del Libro Mayor y en la forma que ambos tienen de tratar las operaciones de trueque. Es un hecho que Manzoni (1540 está presente en The moner and fourme en lo tocante a la numeración de las partidas en el Diario y a su referencia en el texto. Por lo que se refiere a la organización de los libros de cuentas, también existen resonancias de Weddington. La excelencia es la cualidad que destaca en los dos tratado, en particular en The pathe waye. Peele supo recoger en sus libros las tendencias más innovadoras de la partida doble provenientes de los autores que le precedieron. Está demostrado que Mellis manejó, aunque no siempre de forma apropiada, los tratados de Peele para su reedición de Oldcastle (1588. Y se puede decir lo mismo de John Carpenter (1632. Pele comprendió los verdaderos principios de la partida doble; pero sus excelentes tratados se quedaron injustamente olvidados en la penumbra de los pretextos, la competencia de los contextos y casi ningún paratexto que los valorara en su justiprecio que fue, y sigue siendo, elevado.The present paper tries to have a look, from a broad perspective, at James Peele's two treatises (1553, 1569. The pathe waye (1569, as a whole, drifts away considerably from the treatises previously

  15. Rescue of the albino phenotype by introducing a functional tyrosinase minigene into Kunming albino mice

    Institute of Scientific and Technical Information of China (English)

    Dong Xiao; Kang Xu; Xi-Gu Chen; Ying Yue; Xin-Yan Deng; Bing Huang; Zhong-Min Guo; Yun Ma; Yi-Li Lin; Xun Hong; Huan Tang

    2007-01-01

    AIM: To use the tyrosinase minigene as a visual marker to perform microinjection training and improve the techniques related with transgene to greatly elevate the efficiency of gene transfer.METHODS: A mouse tyrosinase minigene, i.e., TyBS,in which the 2.25-kb authentic genomic 5' non-coding flanking sequence of mouse tyrosinase was fused to a mouse tyrosinase cDNA, was introduced into the fertilized eggs of outbred Kunming albino mice.RESULTS: Of the 11 animals that developed from the injected eggs, two mice (P1 and #8) exhibited pigmented hair (P1) and eyes (P1 and #8), as confirmed by PCR analysis for the tyrosinase minigene integrated into the genome. When founder P1 was bred to Kunming male mouse, six progeny out of 11 offspring inherited the transgene and the pigmented-eye phenotype.CONCLUSION: Taken together, these results suggest that this minigene encodes the active tyrosinase protein and that its 5' flanking region contains the sequences regulating the expression of mouse tyrosinase gene as expected. We have rescued the albino phenotype by introduction and expression of a functional tyrosinase minigene in the Kunming albino mouse and the transgene can be passed to subsequent generation.These findings also indicate that TyBS can be a useful visual marker gene in the co-transgenic experiments.

  16. Effect of lead acetate toxicity on experimental male albino rat

    Directory of Open Access Journals (Sweden)

    Nabil M Ibrahim

    2012-01-01

    Conclusions: It can be concluded that lead acetate has harmful effect on experimental male albino rats. Therefore, the present work advises people to prevent exposure to the lead compound to avoid injurious hazard risk.

  17. El Tratado de Asunción y el Mercosur

    Directory of Open Access Journals (Sweden)

    Miguel Berthet

    2015-10-01

    Full Text Available Texto de la conferencia pronunciada por el Embajador Dr. Miguel Berthet -Director de Relaciones Económicas Internacionales Y de Comercio Exterior de los Ministerios'de Relaciones Exteriores y de Economía y Finaszas- en nuestra Facultad. el 25 de abril de 1991, explicando el significado y alcance del Tratado de Asunción. ,suscrito pocos dias antes de esta exposición. La conferencia estuvo principalmente orientada a dar nociones básicas para los estudiantes

  18. Food Color Induced Hepatotoxicity in Swiss Albino Rats, Rattus norvegicus

    OpenAIRE

    Saxena, Beenam; Sharma, Shiv

    2015-01-01

    Objective: Certain dietary constituents can induce toxicity and play a critical role in the development of several hepatic disorders. Tartrazine, metanil yellow and sunset yellow are widely used azo dyes in food products, so the present study is aimed to investigate the food color induced hepatotoxicity in Swiss albino rats. Materials and Methods: Swiss albino rats were divided into four groups, each group having six animals. Group I served as control, Group II, Group III and Group IV were ad...

  19. ACUTE ORAL TOXICITY OF MUCUNA PRURIENS IN SWISS ALBINO MICE

    OpenAIRE

    Parekar Sushant Shahaji; Somkuwar Arju Parnu

    2011-01-01

    Mucuna pruriens, belonging to the botanical family Fabaceae, has been used in traditional Ayurvedic Indian medicine for various ailments including Parkinson’s disease. The current study reports the outcome of acute oral toxicity investigation of ethanolic extract of M. pruriens (whole plant) on Swiss albino mice. No mortalities or evidence of adverse effects have been observed in Swiss albino mice following acute oral administration of ethanolic extract of M. pruriens at the dose of 2000 mg/...

  20. Desinfección con ozono de los conductos radiculares tratados endodóncicamente

    OpenAIRE

    Lüdi Etchevarren, Viviana Clelia

    2016-01-01

    Este trabajo valora el efecto del ozono gas sobre células planctónicas y biopelículas maduras de E. faecalis, principal responsable de la persistencia de la infección periapical y el fracaso endodóncico. Se utilizaron dos equipos: uno de uso odontológico que proporciona una concentración máxima de ozono gas de 4 μg/mL, y otro de uso médico que consigue una concentración máxima de 80 μg/mL. Se utilizaron dos modelos experimentales. 1) Biopelículas de E. faecalis generadas experimentalmente ...

  1. Cambios en la estabilidad estructural de un Mollisol tratado con Vinaza

    OpenAIRE

    Quiroz Marín, Tatiana; Rojas Palacios, Hernán

    2009-01-01

    La vinaza, subproducto de la destilación de alcohol carburante, se emplea para promover una mejor agregación en los suelos (Camargo, 1983; García, et al. 2006). Se planteó esta investigación, que evaluó el efecto de la aplicación de cuatro diferentes dosis de vinaza (0, 5.000, 10.000 y 15.000 Kg*ha-1) a través del tiempo (dos, cuatro y seis meses después de la aplicación de la vinaza), sobre la estabilidad estructural de un Mollisol. Para la evaluación se emplearon tres métodos de medición: e...

  2. SALES SOLUBLES Y METALES PESADOS EN SUELOS TRATADOS CON BIOSÓLIDOS

    OpenAIRE

    E. Robledo- Santoyo; V. Espinosa Hernández; R. Maldonado Torres; J. E. Rubiños Panta; E. Hernández Acosta; Ojeda Trejo, E.; L. Corlay Chee

    2010-01-01

    Las plantas de tratamientos de aguas residuales (PTAR) generan diariamente toneladas de lodos (biosólidos), los cuales pueden tener un uso agrícola como fuente de nutrientes y material mejorador del suelo, aunque también pueden ser fuente de contaminación por metales pesados y sales solubles. En este estudio se evaluó, en un suelo representativo de la zona de influencia de la PTAR de la ciudad de Aguascalientes, México, la aplicación de biosólidos y el efecto de su contenido de metales pesado...

  3. Implicaciones de la firma del Tratado de Libre Comercio entre Colombia y los Estados Unidos.

    Directory of Open Access Journals (Sweden)

    Olivier Guyottot

    2010-05-01

    Full Text Available Este artículo trata de mostrar que, más allá de su dimensión económica, el Tratado de Libre Comercio entre Estados Unidos y Colombia supone grandes retos políticos y geopolíticos para los dos países. En primera instancia, el TLC le permitiría a los Estados Unidos ampliar su red de acuerdos económicos bilaterales y constituye para Colombia una posibilidad de mejorar su presencia en el mercado norteamericano. Desde la perspectiva estadounidense, Colombia se convierte en un aliado y en un elemento crucial de influencia pro-norteamericana en Suramérica, en un contexto de inestabilidad; además de ser un apoyo en la lucha contra el terrorismo. Del lado colombiano, el Estado necesita la ayuda económica, financiera y logística de Estados Unidos para financiar su guerra contra el narcotráfico y los grupos armados. No obstante, el gobierno colombiano debe tener en cuenta los procesos regionales de integración económica, en los cuales está activamente involucrado, y favorecer las relaciones diplomáticas y comerciales con sus vecinos.

  4. The brainstem efferent acoustic chiasm in pigmented and albino rats.

    Science.gov (United States)

    Reuss, Stefan; Closhen-Gabrisch, Stefanie; Closhen, Christina

    2016-02-01

    The present study examined whether structural peculiarities in the brain-efferent pathway to the organ of Corti may underlie functional differences in hearing between pigmented and albino individuals of the same mammalian species. Pigmented Brown-Norway rats and albino Wistar rats received unilateral injections of an aqueous solution of the retrograde neuronal tracer Fluorogold (FG) into the scala tympani of the cochlea to identify olivocochlear neurons (OCN) in the brainstem superior olivary complex. After five days, brains were perfusion-fixed and brainstem sections were cut and analyzed with respect to retrogradely labeled neurons. Intrinsic neurons of the lateral system were located exclusively in the ipsilateral lateral superior olive (LSO) in both groups. Shell neurons surrounding the LSO and in periolivary regions, which made up only 5-8% of all OCN, were more often contralaterally located in albino than in pigmented animals. A striking difference was observed in the laterality of neurons of the medial olivocochlear (MOC) system, which provided more than one third of all OCN. These neurons, located in the rostral periolivary region and in the ventral nucleus of the trapezoid body, were observed contralateral to 45% in pigmented and to 68% in albino animals. Our study, the first to compare the origin of the olivocochlear bundle in pigmented and albino rats, provides evidence for differences in the crossing pattern of the olivocochlear pathway. These were found predominantly in the MOC system providing the direct efferent innervation of cochlear outer hair cells. Our findings may account for the alterations in auditory perception observed in albino mammals including man. PMID:26657095

  5. Suscetibilidade aos agentes quimioterápicos de isolados de Schistosoma mansoni oriundos de pacientes tratados com oxamniquine e praziquantel e não curados

    Directory of Open Access Journals (Sweden)

    Neusa Araújo

    1996-10-01

    Full Text Available Foram estudados dez isolados de Schistosoma mansoni provenientes de pacientes residentes em Itaquara, Bahia, Brasil, tratados com oxamniquine eposteriormente com praziquantel, e ainda assim não curados. Caramujos (Biomphalaria glabrataj foram expostos a miracídios provenientes das fezes dos pacientes. Cercãrías eliminadas por estes caramujos e por moluscos coletados no peridomicílio dos pacientes foram utilizadas para infecção experimental de camundongos albinos. Os animais infectados foram tratados em dose única, via oral, com oxamniquine (25, 50 e 100 mg/kg ou praziquantel (100, 200 e 400mg/kg. Foram realizados estudos de análise e comparação de DNA de cercãrías de S. mansoni eliminadas pelos caramujos e de vermes adultos recolhidos de camundongos infectados experimentalmente com os isolados dos 10 pacientes e ainda de cercãrías de S. mansoni eliminadas por moluscos naturalmente infectados coletados em Itaquara. A cepa LE (mantida rotineiramente no laboratório foi usada como padrão de comparação da resposta aos agentes esquistossomicidas administrados. As respostas terapêuticas foram significativamente diferentes entre alguns dos isolados embora não fosse possível caracterizar nenhum como resistente. A análise dos perfis de amplificação de DNA nas cercãrías e nos vermes adultos dos isolados de S. mansoni demonstrou baixo grau de variabilidade indicando que estes são geneticamente próximos e revelando a ausência de rearranjos globais dentro dos genomas.

  6. Evaluation of analgesic activity of perindopril in albino mice

    OpenAIRE

    Suresha, R. N.; Siddamma Amoghimath; Vaibhavi, P. S.; Shruthi, S L; M.K. Jayanthi; H L Kalabharathi

    2014-01-01

    The aim was to evaluate the analgesic activity of perindopril in chemical, thermal and mechanical pain on Swiss albino mice. A total of 54 albino mice (Swiss strain) weighing 25-30 g were allocated to each experimental model and in each model there were three groups. The control group received normal saline (25 ml/kg) per orally, standard group received pentazocine (10 mg/kg) intra-peritoneal and test groups received perindopril (1 mg/kg) per orally. Perindopril and normal saline was administ...

  7. CONTENIDO DE FENOLES TOTALES EN FRUTOS DE MANGO ′SUPER HADEN′ DAÑADOS POR ANTRACNOSIS Y TRATADOS EN POSCOSECHA

    OpenAIRE

    Akira Pérez Márquez; Yamile Vidal Aguiar; Tania Mulkay Vitón

    2016-01-01

    El contenido de fenoles totales en el exocarpio de los frutos tiene relación con los mecanismos de defensa propios del fruto frente al ataque por patógenos fúngicos. Colletotrichum gloeosporioides (Penz.) Penz. & Sacc. es causante de la antracnosis en el mango (Mangifera indica L.) y ocasiona elevadas pérdidas en poscosecha. El objetivo de este trabajo fue evaluar el contenido de fenoles totales en frutos de mango ‘Super Haden’ dañados y tratados en poscosecha y evi...

  8. Los mecanismos de control de la aplicación y del cumplimiento de los tratados internacionales multilaterales de protección del medio ambiente

    OpenAIRE

    Borràs Pentinat, Susana

    2007-01-01

    LOS MECANISMOS DE CONTROL DE LA APLICACIÓN Y DEL CUMPLIMIENTO DE LOS TRATADOS INTERNACIONALES MULTILATERALES DE PROTECCIÓN DEL MEDIO AMBIENTETesis presentada para aspirar al título de Doctor/a en Derecho por:Susana BORRÀS PENTINATRealizada bajo la dirección del Dr. Antoni Pigrau SoléCatedrático de Derecho Internacional Público yRelaciones Internacionales 2007Abstract:The PhD thesis, entitled "Control Mechanisms on the implementation and compliance with Multilateral Environmental Treaties",con...

  9. Ventilación con liberación de presión en la vía aérea, en neonatos con insuficiencia respiratoria aguda

    OpenAIRE

    Emmanuel Jiménez-Castro; Olman Coronado-García; Leonardo Orozco-Saborio; Alicia Boza-Mora

    2013-01-01

    La ventilación con liberación de presión en la vía aérea (APRV)es una modalidad ventilatoria que utiliza presión positiva controlada en la vía aérea, con el fin de maximizar el reclutamiento alveolar, con tiempos inspiratorios prolongados, permitiendo la respiración espontánea durante ambas fases del ciclo respiratorio. Los autores describen su experiencia en una serie de 12 casos con pacientes neonatales con insuficiencia respiratoria aguda, que fueron tratados con la APRV ventilación con li...

  10. Differences in MITF gene expression and histology between albino and normal sea cucumbers ( Apostichopus japonicus Selenka)

    Science.gov (United States)

    Zhao, Heling; Yang, Hongsheng; Zhao, Huan; Liu, Shilin; Wang, Tianming

    2012-01-01

    Albino Apostichopus japonicus occur both in the wild and in captivity. The offspring of albino A. japonicus also suffer from albinism. The formation of melanin in the melanocytes is dependant on microphthalmia-associated transcription factor (MITF). To investigate the role of MITF in controlling albinism, we cloned the full-length MITF cDNA from A. japonicus and compared MITF mRNA expression in albino and normal A. japonicus. In addition, we used light and electron microscopy to compare histological samples of normal and albino A. japonicus. The body wall of albino adults was characterized by significantly lower levels of MITF expression and lower numbers of epidermal melanocytes, which also contained less melanin. In albino juvenile offspring, MITF expression levels were significantly lower 32 d after fertilization and there were fewer, and less developed, epidermal melanocytes. Thus, we conclude that albino A. japonicus have fewer melanocytes and a reduced ability to synthesize melanin, likely because of lower expression of MITF.

  11. Evaluación económica de rituximab en combinación con fludarabina y ciclofosfamida en comparación con fludarabina y ciclofosfamida en el tratamiento de la leucemia linfática crónica Economic evaluation of rituximab added to fludarabine plus cyclophosphamide versus fludarabine plus cyclophosphamide for the treatment of chronic lymphocytic leukemia

    OpenAIRE

    Luis Felipe Casado; José Antonio García Marco; Florinda Gilsanz; Marcos González; Eduardo Ríos; Javier de la Serna; Álvaro Urbano; Vicente Vicente; Carlos Rubio-Terrés; Castro, Antonio J.

    2011-01-01

    Objetivos: Evaluar el coste-efectividad del esquema de rituximab, fludarabina y ciclofosfamida (R-FC) en comparación con el de fludarabina y ciclofosfamida (FC) en dos tipos de pacientes con leucemia linfática crónica (LLC): no tratados previamente o bien en recidiva/resistentes al tratamiento previo. Métodos: Dos modelos de Markov, utilizando los resultados publicados de superviviencia libre de progresión (SLP) de pacientes con LLC tratados con R-FC o FC en primera o segunda línea, las tasas...

  12. Evaluación de la fusión segmentaria con técnica TLIF con cajas de PEEK en patología degenerativa lumbar: ¿ es la radiografía dinámica útil para el diagnóstico de fusión segmentaria en pacientes tratados? Avaliação de fusão intersomática com técnica TLIF e dispositivo em PEEK em degeneração lombar: a radiografia dinâmica é útil para o diagnóstico da fusão intersomática em pacientes tratados? Evaluation of the intersomatic fusion with TLIF technique and PEEK cages: is the dynamic X Ray useful for the diagnosis for intersomatic fusion in instrumented patients?

    Directory of Open Access Journals (Sweden)

    Alejandro Ferrer

    2012-06-01

    Full Text Available OBJETIVO: Evaluar la eficiencia de las radiografías dinámicas en el diagnóstico de fusión intersomática mediante la comparación interobservador con TAC haciéndose cortes finos y reconstrucción en 3D. MÉTODO: Fueron evaluados 25 pacientes, entre diciembre de 2004 y marzo de 2010, operados por medio de técnica TLIF con caja de PEEK, chips óseos autólogos de cresta ilíaca (precaja e intracaja e instrumentación pedicular de titanio en 1 solo segmento lumbar. Estos 25 casos fueron evaluados en forma aleatoria por los 3 autores del trabajo; las radiografías dinámicas consignaron en cada una si el segmento presentaba fusión (A o no (B según el hallazgo de movilidad segmentaria. De la misma manera, se evaluaron los cortes de TAC, buscando el signo centinela y el signo centinela posterior (A presente y (B ausente. RESULTADOS: Según la apreciación de los autores y de acuerdo con la lectura de las Rx dinámicas, 24 de los 25 pacientes (96% no presentaban movilidad segmentaria alguna, considerándos elos, por ende, fusionados. Por el contrario, la observación de las TAC con cortes de 1mm y reconstrucción en 3D mostró signos compatibles con fusión en 17 pacientes (68%. CONCLUSIÓN: El método de selección para el diagnóstico de fusión intersomática es la TAC con cortes de 1mm y reconstrucción en 3D.OBJETIVO: Avaliar a eficiência de radiografias dinâmicas no diagnóstico de artrodese por meio da comparação interobservadores com TC de corte fino e reconstrução 3D. MÉTODOS: Foram avaliados 25 pacientes operados entre dezembro de 2004 e março de 2010 pela técnica TLIF e uso do dispositivo em PEEK, utilizando-se lascas ósseas de osso autólogo da crista ilíaca (pré-dispositivo e intradispositivo e instrumentação com parafusos pediculares de titânio em um único nível lombar. Esses 25 casos foram randomicamente avaliados pelos três autores; os casos foram classificados por presença ou ausência de mobilidade segmentar

  13. Therapeutic Efficacy of Ginger, Cisplatin and Radiation on Chemically-Induced Cancer in Male Albino Rats

    International Nuclear Information System (INIS)

    This study aimed to investigate the in vivo effect of dietary supplementation with ginger to evaluate its therapeutic effect against lung and kidney cancer and in combination with cisplatin as chemotherapy and radiotherapy in male albino rats. 54 male albino rats were divided into nine groups of 6 animals each, all animals were allowed to food and water ad libitum . Group I was treated with 0.5 ml saline, orlly for 12 consecutive weeks serve as con - trol group Group II injected with N-nitrosodimethylamine (NDMA) and carbon tetrachloride (CCl4 ); all groups were injected with NDMA + CCl4 for 6 weeks. Group III were given ginger for 6 consecutive weeks (200 mg/kg, b.wt./day). Group IV animals received cisplatin, group V irradiated with 2 Gy, group VI treated with ginger then irradiated, group VII treated with ginger then injected with cisplatin, group VIII injected with cisplatin then irradiated and group IX treated with ginger and cisplatin then irradiated. Antioxidant status in both kidney and lung tissues were estimated by determining the activity of antioxidant enzyme superoxide dismutase (SOD); as well as the level of reduced glutathione (GSH), Malondialdehyde (MDA) and Nitric oxide (NO). In parallel to histopathological investigations of lung and kidney tissues. In addition, Tumor Necrosis Factor Alpha (TNF-α) level, advanced oxidative protein product (AOPP), urea, creatinine and uric acid. Remarkable disturbances were observed in the levels of all tested parameters in NDMA + CCl4 group. On the other hand, rats injected with the cancer agents then treated with cisplatin+radiation showed moderate improvements in the studied parameters while, treatment with ginger + cisplatin + radiation ameliorated the levels of the disturbed bio

  14. La igualdad de genero en el Tratado Constitucional de la Unión Europea

    Directory of Open Access Journals (Sweden)

    Emanuela Lombardo

    2012-02-01

    Full Text Available El artículo analiza el tratamiento de la igualdad de género en el Tratado Constitucional Europeo de 2004, con especial referencia a la incorporación de una perspectiva de género en el proceso. Evalúa tanto los resultados positivos, relacionados con el mantenimiento del acervo comunitario en materia de igualdad, la inclusión de la Carta de los Derechos Fundamentales de la UE, y las movilizaciones a favor de la igualdad dentro y fuera de la Convención, como los resultados negativos, concernientes a la limitada capacidad de incorporar una perspectiva  de género en el proceso y en el texto constitucional. Ésta se atribuye al concepto estrecho de igualdad de género adoptado en el documento, a las resistencias en incorporar una perspectiva de género en todas las áreas políticas, a la baja representación de las mujeres en la Convención, y a la ausencia de una perspectiva de género en el proceso institucional y administrativo. En la conclusión se avanzan algunas hipótesis explicativas de dichas limitaciones. The article analyses the treatment of gender equality in the 2004 European Constitutional Treaty, with particular reference to the incorporation of a gender perspective in the process. The assessment includes positive results, that are related to the maintenance of the acquis cornrnmunautaire on equality, the inclusion of the Charter of Fundamental Rights, and the mobilisation in favour of equality within and outside the body of the Convention. It also considers the negative results that have to do with the limited capacity to incorporate a gender perspective into the process and the text of the Constitution. This limits are attributed to the narrow concept of gender equality adopted in the document, the resistance to incorporate a gender perspective into all policy areas, the low representation of women in the Convention, and the absence of a gender perspective in the institutional and administrative process. The

  15. Chelala, Ninou. – L’albinos en Afrique

    OpenAIRE

    Missié, Jean-Pierre

    2011-01-01

    Au moment où les médias internationaux se délectent de faits divers relatant les actes de violence faite aux albinos en Afrique de l’Est notamment (crimes en vue de prélever des parties du corps pour des besoins de fétiches, viol, stigmatisations), ce livre vient fort à propos bien qu’il semble n’avoir pas été suffisamment relu. Il pose malgré tout des questions pertinentes. Articulé sur trois chapitres (« Inventions historico-sociales de l’albinos » ;« La construction de l’identité de l’alb...

  16. ACUTE ORAL TOXICITY OF MUCUNA PRURIENS IN SWISS ALBINO MICE

    Directory of Open Access Journals (Sweden)

    Parekar Sushant Shahaji

    2011-05-01

    Full Text Available Mucuna pruriens, belonging to the botanical family Fabaceae, has been used in traditional Ayurvedic Indian medicine for various ailments including Parkinson’s disease. The current study reports the outcome of acute oral toxicity investigation of ethanolic extract of M. pruriens (whole plant on Swiss albino mice. No mortalities or evidence of adverse effects have been observed in Swiss albino mice following acute oral administration of ethanolic extract of M. pruriens at the dose of 2000 mg/ kg. This is the first report on the acute oral toxicity of M. pruriens and thus the findings of this study provide scientific validation on the use of the M. pruriens as a medicine for treating various ailments.

  17. COMPARATIVE ANTIHYPERLIPIDAEMIC EFFICACY OF TRACHYSPERMUM AMMI EXTRACTS IN ALBINO RABBITS

    Directory of Open Access Journals (Sweden)

    I. JAVED, Z. IQBAL, Z. U. RAHMAN, F. H. KHAN, F. MUHAMMAD, B. ASLAM AND L. ALI1

    2006-01-01

    Full Text Available Comparative antihyperlipidaemic efficacy of Trachyspermum ammi (L Sprague (Ajowain extracts in chloroform, methanol, petroleum ether and water was investigated in albino rabbits. Hyperlipidaemia was induced with butter fed ad libitum and oral intubation of cholesterol 400 mg/kg body weight. Simvastatin was used as a synthetic cholesterol lowering drug. The results suggested that chloroform and water extracts of T. ammi seed had no hypolipidaemic activity. However, methanol and petroleum ether extracts equivalent to its 2 g/kg body weight powder and Simvastatin (0.6 mg/kg body weight were equally effective in treating hyperlipidaemia in albino rabbits. Moreover, petroleum ether extract appeared to be more potent than methanol extract on the basis of increasing the level of HDL-cholesterol and lowering the LDL-cholesterol more effectively than methanol extract. Petroleum ether extract reduced atherogenic index (total cholesterol/HDL-cholesterol more effectively than methanol extract.

  18. Immunomodulatory Activity of Abutilon Indicum linn on Albino Mice

    OpenAIRE

    N. L. Dashputre; , N. S. Naikwade

    2010-01-01

    Purpose: To study the immunomodulatory activity of aqueous and ethanol extracts of leaves of Abutilon indicum Linn. (Family: Malvaceae) on albino mice. Methods: The ethanolic and aqueous extract of leaves of Abutilon indicum was administered orally at the dosage levels of 200 mg/kg/day and 400 mg/kg/day body weight in mice. The assessment of immunomodulatory activity on specific and non-specific immunity were studied by heamagglutination antibody (HA) titer, delayed type hypersensitivity (DTH...

  19. Preliminary acute toxicity study on imidacloprid in Swiss albino mice

    OpenAIRE

    Preeti Bagri; Vinod Kumar; Anil Kumar Sikka; Joginder Singh Punia

    2013-01-01

    Aim: To ascertain the maximum tolerated dose (MTD) and to investigate the acute oral toxic effects of imidacloprid towards Swiss albino male mice.Materials and Methods: The MTD of imidacloprid was determined in pilot dose range finding study following the standard method. Animals were observed for toxic signs and symptoms after oral administration of MTD of imidacloprid in single dose. The body weights of animals were recorded on alternate day. Animals were sacrificed on 14th day and changes ...

  20. Linfoma hepático primario: Evolución favorable con quimioterapia combinada con rituximab Primary hepatic lymphoma: favorable outcome with chemotherapy plus rituximab

    Directory of Open Access Journals (Sweden)

    I. Serrano-Navarro

    2008-11-01

    Full Text Available Comunicamos el caso de una paciente con un linfoma hepático primario tratado con éxito con quimioterapia combinada con rituximab. Utilizando los "encabezamientos estándar para búsquedas bibliográficas informatizadas" (Medical Subject Heading revisamos los casos publicados hasta la fecha de esta infrecuente entidad.This article describes the case of a patient with a non-Hodgkin primary hepatic lymphoma who was successfully treated with chemotherapy combined with rituximab. Using the Medical Subject Headings the published reports of this rare entity were reviewed.

  1. Evaluation of analgesic activity of perindopril in albino mice

    Directory of Open Access Journals (Sweden)

    R N Suresha

    2014-01-01

    Full Text Available The aim was to evaluate the analgesic activity of perindopril in chemical, thermal and mechanical pain on Swiss albino mice. A total of 54 albino mice (Swiss strain weighing 25-30 g were allocated to each experimental model and in each model there were three groups. The control group received normal saline (25 ml/kg per orally, standard group received pentazocine (10 mg/kg intra-peritoneal and test groups received perindopril (1 mg/kg per orally. Perindopril and normal saline was administered 2 h before, whereas the pentazocine was administered 15 min prior to Eddy′s hot plate, writhing and tail clip methods. The decrease in number of writhes, the delay in reaction time in tail clip and Eddy′s hot plate method denoted the analgesic activity. Perindopril decreased the number of writhes, delayed the reaction time in tail clip and Eddy′s hot plate method considerably when compared with control (normal saline, but less when compared with standard (pentazocine. Perindopril exhibits analgesic activity in thermal, chemical, and mechanical pain models in albino mice.

  2. CONTENIDO DE FENOLES TOTALES EN FRUTOS DE MANGO ′SUPER HADEN′ DAÑADOS POR ANTRACNOSIS Y TRATADOS EN POSCOSECHA

    Directory of Open Access Journals (Sweden)

    Akira Pérez Márquez

    2016-01-01

    Full Text Available El contenido de fenoles totales en el exocarpio de los frutos tiene relación con los mecanismos de defensa propios del fruto frente al ataque por patógenos fúngicos. Colletotrichum gloeosporioides (Penz. Penz. & Sacc. es causante de la antracnosis en el mango (Mangifera indica L. y ocasiona elevadas pérdidas en poscosecha. El objetivo de este trabajo fue evaluar el contenido de fenoles totales en frutos de mango ‘Super Haden’ dañados y tratados en poscosecha y evidenciar su relación con los mecanismos de defensa frente a la infección por patógenos. Se tomaron muestras de exocarpios de frutos sanos y con niveles de daños ligeros, moderados y severos por la antracnosis, así como en frutos tratados en poscosecha con agua caliente (53 ºC por 5 min, cera polietilénica (10 % ST más imazalil (800 mg L-1, cera polietilénica (10 % ST más imazalil (800 mg L-1 más dos bolsas de Conserver 21 y un testigo sin aplicación. Las muestras se liofilizaron y se determinó el contenido de fenoles totales por el método sugerido por Slinkard y Singleton (1977 con modificaciones. Los frutos afectados por la antracnosis presentaron menores contenidos de fenoles totales en el grado ligero fue de 59,25, en el moderado de 58,63 y en el severo 56,52 mg de ácido gálico g-1de masa fresca, mostrándose diferencias significativas entre los grados y frutos sanos. Los tratamientos poscosecha incrementaron el contenido de fenoles totales. El agua caliente y la combinación de cera polietilénica con imazalil mostró valores de 37,58 y 37,11 mg de ácido gálico g-1respectivamente, en comparación con el testigo que fue 33,94 mg de ácido gálico g-1, existiendo una correspondencia con la disminución de la incidencia de la enfermedad.

  3. Los tratados de arquitectura en los fondos de la Biblioteca Histórica de la Universidad Complutense: una aproximación al estudio de sus procedencias y antiguos poseedores.

    Directory of Open Access Journals (Sweden)

    Lizarraga Echaide, Juan Manuel

    2009-07-01

    Full Text Available La Biblioteca Histórica de la Universidad Complutense de Madrid atesora una importantísima colección de tratados de arquitectura El objeto de este artículo es reconstruir la historia de esta singular colección de libros antiguos de gran riqueza y valor y recuperar la procedencia estos tratados tanto con respecto a las bibliotecas de las instituciones docentes que forman parte de la historia de la Universidad como a las importantes bibliotecas personales que se han ido incorporando a su patrimonio bibliográfico. El conocimiento de las antiguas procedencias constituye una información valiosa que permite nuevas oportunidades de investigación histórica y bibliográfica

  4. Las indicaciones geográficas en el TLC firmado por Colombia y Perú con EUA frente al TLC con Chile.

    Directory of Open Access Journals (Sweden)

    Juan Andrés Zarama Medina

    2007-06-01

    Full Text Available El propósito de este trabajo es hacer un análisis crítico del tratamiento que se ha dado a las Indicaciones Geográficas y mas específicamente a las Denominaciones de Origen en el Tratado de Libre Comercio que firmaron recientemente por Colombia y Perú, con los Estados Unidos (TLC, al que en adelante denominaremos TLC CAN, y compararlo con el TLC firmado con Chile (En adelante TLC CHILE. Para efectos de este trabajo, centraremos nuestra atención de manera específica en la tendencia de estos tratados a tratar las indicaciones geográficas y en especial las denominaciones de origen, como marcas colectivas y de certificación o garantía.

  5. Las indicaciones geográficas en el TLC firmado por Colombia y Perú con EUA frente al TLC con Chile.

    Directory of Open Access Journals (Sweden)

    Juan Andrés Zarama Medina

    2007-01-01

    Full Text Available El propósito de este trabajo es hacer un análisis crítico del tratamiento que se ha dado a las Indicaciones Geográficas y mas específicamente a las Denominaciones de Origen en el Tratado de Libre Comercio que firmaron recientemente por Colombia y Perú, con los Estados Unidos (TLC, al que en adelante denominaremos TLC CAN, y compararlo con el TLC firmado con Chile (En adelante TLC CHILE. Para efectos de este trabajo, centraremos nuestra atención de manera específica en la tendencia de estos tratados a tratar las indicaciones geográficas y en especial las denominaciones de origen, como marcas colectivas y de certificación o garantía.

  6. Logros en educacion secundaria y su relacion con inteligencia y con resolucion de problemas nuevos

    OpenAIRE

    Nuria Cortada de Kohan

    1998-01-01

    En esta investigación, que es una segunda parte de la ya presentada en esta Revista Latinoamericana de Psicología. Vol. 29, N° 1, 1997, hemos tratado de profundizar en la relación entre procesos de pensamiento, inteligencia general y logros en educación. Hemos utilizado un proyecto metodológicamente similar al usado con los alumnos primarios elaborando tests de conocimientoadhoc para alumnos del último año de la Escuela Secundaria. Asimismo hemos aplicado a la misma muestra ...

  7. TRATADOS INTERNACIONALES DE DERECHOS HUMANOS BAJO EL ORDENAMIENTO JURÍDICO ALEMÁN

    Directory of Open Access Journals (Sweden)

    Roland Bank

    2003-01-01

    Full Text Available En el presente artículo el autor analiza la posición de los tratados internacionales en general, como asimismo, los tratados de derechos humanos y de integración en el sistema jurídico alemán, considerando la posición de la doctrina y la jurisprudencia emanada de la Corte Constitucional Alemana.The article analyzes the status in the German legal system of international treaties in general, and treaties on human rights and integration in particular, from the point of view of legal scholarship and the decisions of the German Constitutional Court.

  8. El lugar de la sátira en la poética: los tratados españoles del siglo XIX

    Directory of Open Access Journals (Sweden)

    González Alcázar, Felipe

    2008-12-01

    Full Text Available This article aims to analyse the satirical genre and its connections with Poetics in the Spanish Poetry and Rhetoric precept treatises of the nineteenth century. Throughout that century, literary theory was subject to major changes, such as the success of Hegel’s postulates on literary genres. Satire faces these changes and its own evolution: it was first identified with the Roman satura and afterwards through its various forms, it became a mixed or transitional genre. Its fragile nature seems to confront directly the normative perpetuity of treatises that, in spite of their rupture with romanticism, may be considered inheritors of the classicist principles.Se propone en este artículo investigar el género satírico y sus relaciones con la Poética a través de los tratados poético-retóricos de preceptiva españoles del siglo XIX. A lo largo de toda esa centuria la teoría literaria estuvo sujeta a grandes transformaciones, entre ellas, el triunfo de los principios hegelianos acerca de los géneros literarios. La sátira se enfrenta a esas mismas transformaciones y a su propia evolución: primero, identificada con la satura romana, y luego, a través de sus numerosas formas, convertida en un género mixto o de transición. Su lábil naturaleza parece enfrentarse directamente con la perennidad normativa de los tratados que, a pesar de la ruptura romántica, pueden considerarse herederos de los principios clasicistas.

  9. Calidad de vida de pacientes con cáncer de próstata en tratamiento con bloqueo androgénico continuo vs intermitente: estudio prospectivo mediante la aplicación del cuestionario CAVIPRES

    OpenAIRE

    C.R. Sierra Labarta; D. Sánchez Zalabardo; Á. de Pablo Cárdenas

    2015-01-01

    Fundamento: El tratamiento con bloqueo androgénico intermitente (BAI) pretende mejorar la calidad de vida de los pacientes con cáncer de próstata con los mismos resultados oncológicos que el bloqueo androgénico continuo (BAC). El presente trabajo compara la calidad de vida mediante la aplicación del cuestionario CAVIPRES entre dos grupos de pacientes, uno tratado con BAC y otro con BAI. Material y métodos: Se realizó un estudio longitudinal de 24 meses de duración que incluyó 114 pacientes. T...

  10. Oral toxicity of Madhuca butyracea Macb. saponins to albino rats.

    Science.gov (United States)

    Lalitha, T; Vishwanatha, S; Venkataraman, L V

    1990-07-01

    Saponins, isolated from M. butyracea, were assessed for their acute and subacute oral toxicity in albino rats. Acute doses of saponins caused mortalities and LD50 and LD90 values were 330 and 430 mg/kg body wt respectively. Severe diarrhoea, restlessness and histopathological changes were observed in liver and kidney. Diets containing saponins at 0,250,500 and 1000 ppm for 14 weeks did not affect food intake, growth or organ weights, but induced mild histological changes in liver and kidney and altered the serum levels of alkaline phosphatase, blood urea nitrogen, cholesterol and proteins, particularly in female rats. PMID:2272650

  11.  Miners’ magic: artisanal mining, the albino fetish and murder in Tanzania

    DEFF Research Database (Denmark)

    Bryceson, Deborah; Jønsson, Jesper Bosse; Sherrington, Richard

    2010-01-01

    purchase the albino charms, the waganga healers renowned for their healing, divination and sorcery skills who prescribe and sell the charms, and the albino murder victims. The agrarian background, miners’ ambitions and a clash of values comprise our starting point for understanding the victimisation...

  12. Forkhead containing transcription factor Albino controls tetrapyrrole-based body pigmentation in planarian.

    Science.gov (United States)

    Wang, Chen; Han, Xiao-Shuai; Li, Fang-Fang; Huang, Shuang; Qin, Yong-Wen; Zhao, Xian-Xian; Jing, Qing

    2016-01-01

    Pigmentation processes occur from invertebrates to mammals. Owing to the complexity of the pigmentary system, in vivo animal models for pigmentation study are limited. Planarians are capable of regenerating any missing part including the dark-brown pigments, providing a promising model for pigmentation study. However, the molecular mechanism of planarian body pigmentation is poorly understood. We found in an RNA interference screen that a forkhead containing transcription factor, Albino, was required for pigmentation without affecting survival or other regeneration processes. In addition, the body color recovered after termination of Albino double stranded RNA feeding owing to the robust stem cell system. Further expression analysis revealed a spatial and temporal correlation between Albino and pigmentation process. Gene expression arrays revealed that the expression of three tetrapyrrole biosynthesis enzymes, ALAD, ALAS and PBGD, was impaired upon Albino RNA interference. RNA interference of PBGD led to a similar albinism phenotype caused by Albino RNA interference. Moreover, PBGD was specifically expressed in pigment cells and can serve as a pigment cell molecular marker. Our results revealed that Albino controls planarian body color pigmentation dominantly via regulating tetrapyrrole biogenesis. These results identified Albino as the key regulator of the tetrapyrrole-based planarian body pigmentation, suggesting a role of Albino during stem cell-pigment cell fate decision and provided new insights into porphyria pathogenesis. PMID:27551436

  13. Spatiotemporal features of early neuronogenesis differ in wild-type and albino mouse retina

    Science.gov (United States)

    Rachel, Rivka A.; Dolen, Gul; Hayes, Nancy L.; Lu, Alice; Erskine, Lynda; Nowakowski, Richard S.; Mason, Carol A.

    2002-01-01

    In albino mammals, lack of pigment in the retinal pigment epithelium is associated with retinal defects, including poor visual acuity from a photoreceptor deficit in the central retina and poor depth perception from a decrease in ipsilaterally projecting retinal fibers. Possible contributors to these abnormalities are reported delays in neuronogenesis (Ilia and Jeffery, 1996) and retinal maturation (Webster and Rowe, 1991). To further determine possible perturbations in neuronogenesis and/or differentiation, we used cell-specific markers and refined birth dating methods to examine these events during retinal ganglion cell (RGC) genesis in albino and pigmented mice from embryonic day 11 (E11) to E18. Our data indicate that relative to pigmented mice, more ganglion cells are born in the early stages of neuronogenesis in the albino retina, although the initiation of RGC genesis in the albino is unchanged. The cellular organization of the albino retina is perturbed as early as E12. In addition, cell cycle kinetics and output along the nasotemporal axis differ in retinas of albino and pigmented mice, both absolutely, with the temporal aspect of the retina expanded in albino, and relative to the position of the optic nerve head. Finally, blocking melanin synthesis in pigmented eyecups in culture leads to an increase in RGC differentiation, consistent with a role for melanin formation in regulating RGC neuronogenesis. These results point to spatiotemporal defects in neuronal production in the albino retina, which could perturb expression of genes that specify cell fate, number, and/or projection phenotype.

  14. Forkhead containing transcription factor Albino controls tetrapyrrole-based body pigmentation in planarian

    Science.gov (United States)

    Wang, Chen; Han, Xiao-Shuai; Li, Fang-Fang; Huang, Shuang; Qin, Yong-Wen; Zhao, Xian-Xian; Jing, Qing

    2016-01-01

    Pigmentation processes occur from invertebrates to mammals. Owing to the complexity of the pigmentary system, in vivo animal models for pigmentation study are limited. Planarians are capable of regenerating any missing part including the dark-brown pigments, providing a promising model for pigmentation study. However, the molecular mechanism of planarian body pigmentation is poorly understood. We found in an RNA interference screen that a forkhead containing transcription factor, Albino, was required for pigmentation without affecting survival or other regeneration processes. In addition, the body color recovered after termination of Albino double stranded RNA feeding owing to the robust stem cell system. Further expression analysis revealed a spatial and temporal correlation between Albino and pigmentation process. Gene expression arrays revealed that the expression of three tetrapyrrole biosynthesis enzymes, ALAD, ALAS and PBGD, was impaired upon Albino RNA interference. RNA interference of PBGD led to a similar albinism phenotype caused by Albino RNA interference. Moreover, PBGD was specifically expressed in pigment cells and can serve as a pigment cell molecular marker. Our results revealed that Albino controls planarian body color pigmentation dominantly via regulating tetrapyrrole biogenesis. These results identified Albino as the key regulator of the tetrapyrrole-based planarian body pigmentation, suggesting a role of Albino during stem cell-pigment cell fate decision and provided new insights into porphyria pathogenesis. PMID:27551436

  15. Antidiarrheal Activity of Three Medicinal Plants in Swiss Albino Mice

    Directory of Open Access Journals (Sweden)

    MD. Ashrafuzzaman

    2016-09-01

    Full Text Available Background: Different parts of Allamanda neriifolia (AN, Crinum latifolium (CL, and Bruguiera cylindrical (BC are used in folk medicine to treat diarrhea. Therefore, the aim of this study was to investigate and compare possible antidiarrheal activity of methanol extracts from barks, stems, and roots of AL, CL, and BC in Swiss albino mice. Methods: Antidiarrheal activities of extracts were evaluated at three doses (100mg/kg, 200 mg/kg and 400mg/kg and compared with Loperamide in a castor oil-induced diarrhea and charcoal meal test model in the Swiss albino mice. Results: The aqueous extract of CL and BC administered at doses of 100, 200 and 400mg/kg showed 0%, 24.5%, 62.26% and 5.66%, 37.11%, and 62.26% diarrhea inhibition, respectively (Table 2. This reduction in diarrheal episodes is significant, and maximum effect was observed at the dose of 400mg/kg similarly in the alcohol extracts of both CL and BC. AN administered at the dose of 100, 200 and 400mg/kg showed 55.97%, 74.84% and 74.84% diarrhea inhibition, respectively. Conclusion: The antidiarrheal effect of the AN extract, in contrast to CL and BC, against the castor oil-induced diarrhea model prove its efficacy in an extensive range of diarrheal conditions.

  16. Melanoma maligno em búfalos (Bubalus bubalis albinos

    Directory of Open Access Journals (Sweden)

    Maria Cecília Florisbal Damé

    2015-10-01

    Full Text Available Descrevem-se melanomas múltiplos em dois búfalos albinos da raça Murrah no Sul do Brasil. Macroscopicamente havia múltiplos tumores enegrecidos no músculo esquelético, pulmões, linfonodos, saco pericárdio, cápsula renal, mediastino e pleura. Microscopicamente foram observadas células epitelióides poliédricas dispostas em ninhos sólidos ou fascículos entrelaçados sustentadas por um estroma colagenoso fino e esparso. O citoplasma era eosinofílico e por vezes continham quantidades variáveis de pigmento de melanina. A taxa de mitose foi baixa. Na imuno-histoquímica houve imunomarcação positiva utilizando anticorpo anti-tirosinase, anti-Melan-A, anti-vimentina, anti-proteína S-100 e antineurofilamento. É possível que o polimorfismo relacionado com o gene da pigmentação em búfalos albinos tenha contribuído para o maior risco de desenvolvimento de melanomas, como foi sugerido em humanos.

  17. Solución de controversias en los tratados bilaterales de inversión: mapa de situación en América del Sur

    Directory of Open Access Journals (Sweden)

    Magdalena Bas Vilizzio

    2015-03-01

    Full Text Available Este trabajo analiza las características particulares del sistema legal internacional de solución de controversias inversor-Estado, con especial foco en los tratados bilaterales de inversión (TBI en vigor en América del Sur, salvo excepciones. En este marco, aplicando la teoría de los regímenes internacionales (Krasner, 1983, se examinan las tres posiciones de los Estados de la región en torno al tema: 1 no ratificar TBI ni ser miembro del Centro Internacional de Arreglo de Diferencias relativas a Inversiones (CIADI (Brasil; 2 denunciar los TBI en vigor y abandonar el CIADI (Bolivia, Ecuador y Venezuela; 3 mantener los TBI en vigor y permanecer en los foros de solución de controversias actuales (Argentina, Chile, Colombia, Guyana, Paraguay, Perú, Surinam y Uruguay.

  18. Técnica dramática y retórica de las pasiones en el Tratado completo del arte del canto de Manuel García

    Directory of Open Access Journals (Sweden)

    Díaz Marroquín, Lucía

    2007-12-01

    Full Text Available The history of European singing technique, from the Italian origins of the stile rappresentativo and the early Seicento musical drama to the heights of bel canto, seems inextricably related to the classical rhetorical and philosophical theories, later re-interpreted by the humanist and rationalist authors. Manuel García’s Tratado completo del arte del canto inherits this tradition and contributes to it with every single observation or musical example included in this eminently practical work.

    Desde los orígenes italianos del stile rappresentativo y del drama musical, en los últimos años del siglo XVI y primeros del XVII, hasta el esplendor del bel canto, la historia de los tratados de canto europeos se encuentra inseparablemente asociada a las teorías retóricas y filosóficas clásicas, más tarde reinterpretadas por los autores humanistas y preenciclopedistas. Al escribir su Tratado completo del arte del canto, una obra eminentemente práctica, Manuel García hereda esta tradición y contribuye a ella con cada una de las observaciones y ejemplos musicales que propone.

  19. Importancia de las MIPYME, las oportunidades en los tratados de libre comercio y la gestión estratégica integral (GESI

    Directory of Open Access Journals (Sweden)

    Jose Antonio Riascos Gonzalez

    2013-12-01

    Full Text Available Existen varios aspectos que es importante tener presentes cuando se hace referencia a temas como las MIPYMES, los Tratados de Libre Comercio TLC y la Gestión Estratégica Integral GESI. En este artículo se hace una corta introducción sobre cómo se identifican en la Ley Colombiana las micro, pequeñas y medianas empresas, incluyendo algunas problemáticas indicadas por algunas entidades como la Cámara de Comercio de Medellín, y una investigación reciente desarrollada en el Informe MIPYME Iberoamérica 2011 FAEDPYME en el que se plantean aspectos de la estrategia empresarial de estas organizaciones. Luego se aborda la definición de TLC y los temas de negociación con sus oportunidades, ofrecidas por algunos países en los tratados que ha firmado o está firmando el gobierno Colombiano, complementando con un análisis de Pareto de los países que más oportunidades ofrecen; para finalmente plantear el modelo de Gestión Estratégica Integral que se presenta como un mapa a seguir por cualquier organización para formular las mejores estrategias, y que incluye una ruta: el Diamante de la Gestión Estratégica, como una opción que puede recorrer cualquier empresa para buscar la competitividad y el desarrollo sostenible

  20. ANÁLISIS DEL PERFIL DE COMPUESTOS VOLÁTILES DEL MANGO (Mangifera indica L. Var. Tommy Atkins TRATADO POR MÉTODOS COMBINADOS

    Directory of Open Access Journals (Sweden)

    Angélica Moreno

    2010-09-01

    Full Text Available Se evaluó el perfil de compuestos volátiles del mango (Mangifera indica L. Var. Tommy Atkins al ser tratado con la combinación de los métodos de deshidratación osmótica con o sin pulso de vacío (DOPV y DO y con secado por aire caliente o con vacío (SAC y VAC. El tiempo utilizado en la cinética del proceso de DO fue de 42 horas y la DOPV de 30 horas; en los procesos de secado, el SAC se realizó durante 24 horas y el VAC requirió 40 horas. En el perfil de compuestos volátiles del mango fresco analizado por cromatografía de gases acoplada a detector de espectrometría de masas (GC-MS se encontraron compuestos tipo mono y sesquiterpénico, además de ácidos y ésteres grasos. El germacreno D (20,49% fue el compuesto terpénico de mayor abundancia encontrado en el análisis realizado. La cantidad de compuestos volátiles en la fruta procesada fue afectada por la aplicación de DOPV y VAC; sin embargo estas pérdidas fueron menores que en las muestras secadas sin pretratamiento osmótico. En el análisis sensorial realizado, las frutas tratadas con DOPV y DO presentaron una menor intensidad calificada en el olor en comparación con la muestra no pretratada.

  1. La transmisión del saber médico: la vida infantil en la Edad Media a través de los tratados pediátricos y de otras fuentes de la época

    OpenAIRE

    Cabrera Sánchez, Margarita

    2006-01-01

    En este trabajo se analizan diversos temas relacionados con la vida de los niños en la Edad Media, contemplados a través de la información contenida en los tratados médicos y también en los testimonios gráfi cos conservados. La investigación se ha estructurado en diversos capítulos que versan sobre los cuidados que se prodigan a los niños (higiene, vestido, alimentación) y sobre las dolencias más comunes que afectaban a la infancia. In this paper we analyze several topics co...

  2. Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka)

    Institute of Scientific and Technical Information of China (English)

    ZHAO Heling; YANG Hongsheng; ZHAO Huan; LIU Shilin; WANG Tianming

    2012-01-01

    Albino Apostichopus japonicus occur both in the wild and in captivity.The offspring of albino A.japonicus also suffer from albinism.The formation of melanin in the melanocytes is dependant on microphthalmia-associated transcription factor (MITF).To investigate the role of MITF in controlling albinism,we cloned the full-length MITF cDNA from A.japonicus and compared MITF mRNA expression in albino and normal A.japonicus.In addition,we used light and electron microscopy to compare histological samples of normal and albino A.japonicus.The body wall of albino adults was characterized by significantly lower levels of MITF expression and lower numbers of epidermal melanocytes,which also contained less melanin.In albino juvenile offspring,MITF expression levels were significantly lower 32 d after fertilization and there were fewer,and less developed,epidermal melanocytes.Thus,we conclude that albino A.japonicus have fewer melanocytes and a reduced ability to synthesize melanin,likely because of lower expression of MITF.

  3. Estudio de las propiedades superficiales y del post-suavizado de tejidos de lana y poliamida 6 tratados con plasma

    OpenAIRE

    Canal, Cristina

    2007-01-01

    La lana es una fibra natural que aunque posee propiedades de confort apreciadas por el consumidor, presenta el inconveniente de encoger durante el lavado en medio acuoso. En una época en que la tendencia en el cuidado de las prendas es el "easy-care" (cuidado fácil), es imperativo que cualquier producto textil sea lavable a máquina. Por ello se han desarrollado numerosos tratamientos para prevenir el encogimiento de las prendas de lana. Sin embargo, la estricta legislación ambiental de los pa...

  4. Infecciones parameníngeas: reporte de dos casos asociados con sinusitis

    Directory of Open Access Journals (Sweden)

    Napoleón González-Saldaña

    2016-02-01

    Full Text Available El absceso cerebral y el empiema subdural son infecciones parameníngeas graves y poco frecuentes en la actualidad. Se presentan un caso de absceso cerebral y uno de empiema subdural asociados con sinusitis; ambos fueron tratados con ceftriaxona, vancomicina y metronidazol (uno de ellos además con drenaje quirúrgico y presentaron evolución clínica satisfactoria. Es importante la sospecha diagnóstica temprana para dar un tratamiento oportuno y mejorar el pronóstico en estos pacientes.

  5. Tratamiento quirúrgico de la espondilolistesis lumbosacra con las técnicas de Candebat

    OpenAIRE

    Echevarría Requeijo, Héctor de la Caridad

    2008-01-01

    Presentamos un estudio descriptivo y longitudinal de tipo prospectivo, en 47 pacientes con espondilolistesis lumbosacra, tratados con las técnicas de Candebat de instrumentación espinal en el Hospital Clínico Quirúrgico “Hermanos Ameijeiras”, desde enero 1999 a septiembre 2006, con el propósito de evaluar los resultados de estas técnicas quirúrgicas. Se seleccionaron los pacientes que no respondieron al tratamiento conservador durante seis meses o más. Veintiún enfermos (44,7%) pertenecen al...

  6. Neuroprotección con ozono en la terapia: nuevos hallazgos en la isquemia cerebral experimental.

    OpenAIRE

    J.D. García Salman; Silvia Menéndez; Rosa María Coro Antich; M. García Cabrera; A. Cuba Peña; Pérez-Saad, H.

    2005-01-01

    El tratamiento con ozono ha mostrado efectos terapéuticos en algunos estados patológicos relacionados con el estrés oxidativo. Nuestro objetivo fue investigar el efecto del tratamiento con ozono en los modelos de isquemia unilateral permanente y de isquemia bilateral transitoria en el gerbo mongol. El ozono se administró por vía rectal (1 mg/Kg). En la isquemia unilateral permanente los animales fueron tratados 3 semanas antes de la ligadura de una carótida. En IBT el tratamiento comenzó ante...

  7. Histopathological effects of doxorubicin on pancreas in male albino rats

    Directory of Open Access Journals (Sweden)

    I.A. Ali

    2015-06-01

    Full Text Available The aim of this study was to investigate the histopathological side effects of doxorubicin on pancreas tissue in male albino rats Rattus norvegicus. This study were used 55 adult rats (2.5-3.5 month of age. The rats divided into two groups, the first group include (35 rats. The second group were (20 rats. Microscopial examination of pancreas lesion demonstrated oedema around the acini, swelling of the epithelial cells of acini, occurance of cystic fibrosis (mucoviscidosis at the concentration of (4,5 mg/kg of body weight ,occurrence of small islets that form of few cells and exocrine-endocrine transformation. There were thickness in the walls of blood vessels, thrombus, congestion of blood vessels, we conclude, that doxorubicin had histopathological effect on pancreas in sub-acute doses more than chronic doses.

  8. The Albino Rat Following Oral Administration Of A-Chlorohydrin

    Directory of Open Access Journals (Sweden)

    Fouad A.F.Ali*, Ali A.Abdel Rahman* and Ashraf M.Moustafa

    2001-09-01

    Full Text Available The antifertility effects of a- chlorohydrin were re-investigated in female albino rats. a.i/Kg. bw of and six females were ! " #$ The uterine changes were in the form of an increase lumenal folding with areas of metaplasia, some cellular vaculization and increased the collogen deposition in the % $ &!rd "th day of the drug intake. The ovarian changes were in the form of decreased number of growing follicles and absence of both Graafian follicles and corpora lutea. It is clear that, treatment of female rats with a chlorohydrin caused reversible uterine and ovarian changes. Uterine changes took longer time to recover compared with that of ovarian changes. These results support the possibility that this drug could be a functional female sterilant as it was known as a male sterilant.

  9. Effect of lead acetate toxicity on experimental male albino rat

    Institute of Scientific and Technical Information of China (English)

    Nabil M Ibrahim; Esam A Eweis; Hossam S El-Beltagi; Yasmin E Abdel-Mobdy

    2012-01-01

    Objective: To evaluate the effect of different doses of lead acetate (1/20, 1/40 and 1/60 of LD50) on body weight gain, blood picture, plasma protein profile and the function of liver, kidney and thyroid gland. Methods: Male albino rats were divided into four groups, the first group represented the health control animals, while the second, third and fourth groups were ingested orally with sub lethal doses of lead acetate (1/20, 1/40 and 1/60) of the oral LD50, respectively. One dose was ingested every two days during the experimental period (14 weeks) including the adaptation time. Blood was collected and used for all analysis. Results: The results showed that, the ingestion of Pb2+ induced significant stimulation in glutamic-pyruvic transaminase (ALT) and glutamic-oxalacetic transaminease (AST) activity. Also, total soluble protein and albumin contents of plasma were significantly decreased, while the content of globulin was changed by the Pb2+ treatments. The cholinesterase activity was inhibited, but the activities of alkaline and acid phosphates and lactate dehydrogenase were stimulated, while plasma glucose level was elevated as a result of lead acetate intoxication. In case of blood picture, Pb2+ ingestion reduced the contents of hemoglobin and RBCs count of intoxicated rat’s blood and the plasma levels of T3, T4 and blood WBCs count were decreased. Conclusions: It can be concluded that lead acetate has harmful effect on experimental male albino rats. Therefore, the present work advises people to prevent exposure to the lead compound to avoid injurious hazard risk.

  10. Preliminary acute toxicity study on imidacloprid in Swiss albino mice

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    Preeti Bagri

    2013-12-01

    Full Text Available Aim: To ascertain the maximum tolerated dose (MTD and to investigate the acute oral toxic effects of imidacloprid towards Swiss albino male mice.Materials and Methods: The MTD of imidacloprid was determined in pilot dose range finding study following the standard method. Animals were observed for toxic signs and symptoms after oral administration of MTD of imidacloprid in single dose. The body weights of animals were recorded on alternate day. Animals were sacrificed on 14th day and changes in hematological parameters (Hb, TEC, TLC and DLC and morphometric measurements (length, breadth, thickness and weight of various body organs (heart, liver, spleen, kidney, testis and epididymis were examined. The student's t-test was applied to statistically analyze the results.Results: The MTD of imidacloprid was determined to be 110 mg/kg body weight. The sign and symptoms of acute toxicity were ataxia, rigidity and fasciculation of muscles, protrusion of eye ball and tremors of head. Imidacloprid treatment resulted in decreased body weight gain as compared to the control group. The changes in hematological parameters were not significant between imidacloprid treated and control groups. Also the values of relative organ weights and morphometric measurements of various body organs did not differ significantly between the control and imidacloprid treated animals.Conclusions: MTD of imidacloprid in Swiss albino male mice through oral route was determined for the first time. Study revealed a non-toxic effect of imidacloprid on body weight, relative organs weight, hematological parameters and morphometric measurements of various body organs in mice.

  11. Tratamiento conservador en pacientes con retinoblastoma bilateral

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    Juan C. Suárez

    2008-11-01

    Full Text Available OBJETIVO: comparar el tratamiento convencional del retinoblastoma bilateral, usado hasta hace algunos años, consistente en radioterapia o enucleación bilateral, con el tratamiento conservador actual que incluye termoterapia transpupilar (TTT o TTT/quimioterapia al menos en un ojo, en niños con diagnóstico de retinoblastoma bilateral. DISEÑO: estudio retrospectivo descriptivo. MUESTRA: 20 pacientes con diagnóstico de retinoblastoma bilateral que consultaron al Hospital Universitario San Vicente de Paúl, de Medellín, Colombia, entre 1997 y 2007. MÉTODO: se hizo enucleación del ojo con el tumor de mayor tamaño. En el otro ojo se hizo tratamiento con TTT, con el láser diodo (810 nm, spot amplio, solo o combinado con otras terapias. RESULTADOS: se dividió a los pacientes en dos grupos: 16 pacientes (32 ojos en el grupo 1 tratados conservadoramente y 4 pacientes (8 ojos en el grupo 2 con tratamiento convencional. El rango de edad fue de 1-72 meses en el grupo 1 y de 1-12 meses en el grupo 2. El tiempo de seguimiento fue de 7-67 meses para el grupo 1 y de 13-73 meses para el grupo 2. En el grupo 1 se hizo enucleación de 16 ojos (50%, radioterapia externa de uno (3,1%, quimioterapia más termoterapia de 5 (15,6% y quimioterapia más termoterapia más crioterapia de 10 (31,3%. En todos los pacientes se logró preservar al menos un ojo. En el grupo 2, se enuclearon 7 ojos (87,5% y se hizo radioterapia externa más enucleación en un paciente (12.5%. Además, todos los pacientes recibieron quimioterapia. CONCLUSIÓN: la terapia conservadora actual consistente en tratamiento local (termoterapia, crioterapia o braquiterapia y quimiorreducción permite preservar al menos un ojo y en algunos casos de los dos, muchas veces con buena agudeza visual, en niños con retinoblastoma bilateral; se evitan así la enucleación bilateral y la radioterapia externa usada en el tratamiento convencional con todos sus efectos secundarios. La enucleación contin

  12. Consequences of Mesobuthus tamulus gangeticus (Pocock, 1900 envenomation in albino mice

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    MK Chaubey

    2010-01-01

    Full Text Available The present study aimed to investigate the effects of Mesobuthus tamulus gangeticus Pocock (Buthidae venom on albino mice (NIH strain. Whole venom was obtained by electrical stimulation and its toxicity was determined in albino mice by subcutaneous envenomation. The venom LD50 was 2.5 mg kg-1 of mouse body weight. Toxic effects on different biochemical and enzymatic parameters in blood serum and other tissues of albino mice were determined after experimental envenomation with sublethal doses of M. tamulus gangeticus venom. Increased levels of glucose, uric acid and cholesterol, as well as decreased serum total proteins, were observed at 2 and 4 hours after the envenomation. In the liver and muscles, glycogen content dropped after venom injection. Moreover, M. tamulus gangeticus venom elevated the enzymatic activity of acid phosphatase (ACP, lactic dehydrogenase (LDH and alanine aminotransferase (ALT in the serum of albino mice. In conclusion, M. tamulus gangeticus can be considered a lethal scorpion species.

  13. Effect of co-administration of voglibose and vildagliptin on diabetic albino rats

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    Umashanker PD Keshri

    2016-08-01

    Conclusions: Vildagliptin and voglibose are effective in lowering blood glucose level in albino diabetic rats but their combination has potentiating effect. [Int J Basic Clin Pharmacol 2016; 5(4.000: 1533-1538

  14. Analgesia profunda con acupuntura / Deep analgesic with acupuncture

    OpenAIRE

    Villate Numa, María Fernanda

    2010-01-01

    El alivio del dolor por medio de la acupuntura se desarrollo en la China moderna después de 1945 con la influencia inicial de la medicina occidental. Según la teoría tradicional, la acupuntura es eficaz sólo cuando las agujas producen el fenómeno “De Qi”, descrito como una sensación ligeramente dolorosa, relajante y si los dedos del acupuntor notan que las agujas son aspiradas por el punto tratado. En el Occidente diferentes estudios han demostrado que la acupuntura estimula fibras aferentes ...

  15. Therapeutic effects of Cassia angustifolia in a cadmium induced hepatotoxicity assay conducted in male albino rats

    OpenAIRE

    Haidry, Muhammad Tahir; Malik, Arif

    2016-01-01

    The present study aims to investigate the therapeutic effects of Senna plant (Cassia angustifolia L.) in a cadmium induced hepatotoxicity assay by evaluating the activity of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and total protein (TP) in the albino rats’ serum. A total of 30 white albino rats were taken and divided into three groups; each group comprising ten rats. The group A was taken as a control group; group B was given cadmium chloride conce...

  16. Behavior of an albino vampire bat, Desmodus rotundus (E. Geoffroy) (Chiroptera, Phyllostomidae), in captivity

    OpenAIRE

    Wilson Uieda

    2001-01-01

    Albinism in the common vampire bat Desmodus rotundus (E. Geoffrey, 1810) was already reported for seven individuals, six of them did in Brazil. Although this species is relatively easy to keep in captivity and many studies with normally pigmented bats were did under laboratory conditions, no reports on detailed observations of captive albino vampire bats were found in literature. This paper reports some behavioral observation of a single albino female D. rotundus kept in captivity in Brazil b...

  17. Ostracism of an Albino Individual by a Group of Pigmented Catfish

    OpenAIRE

    Ondřej Slavík; Pavel Horký; Matúš Maciak

    2015-01-01

    Physiological and behavioural constraints hinder albino individuals. Albino animals are rare in the wild; this trait is associated with easy detection by predators, non-native or damaged environments, and exclusively aphotic environments in total darkness. The social aspect of albinism is reported only for human beings, and the effect is distinguishable in time and space when social benefits, are used to a limited the extent. Thus far, the social consequences of albinism for animals remain un...

  18. Effect of vitamin D on atorvastatin induced blood sugar changes in Wistar albino rats

    OpenAIRE

    Arunkumar, R; Vinayak Meti; A. Ruckmani; Shobita Devi

    2014-01-01

    Background: Statins are hypocholestrolemic agents used in atherosclerotic vascular disorders. They act by inhibiting hepatic hypoxanthine methyl glutaryl CoA reductase enzyme. They are reported to cause hyperglycemia as an important adverse event. This study was conducted to investigate atorvastatin induced blood sugar changes in Wistar, albino, male rats and the influence of vitamin D on the blood sugar changes. Methods: Forty, 12 weeks old male, Wistar albino rats, were selected and rand...

  19. Impact on behavioral changes due to chronic use of sertraline in Wistar albino rats

    OpenAIRE

    Shatavisa Mukherjee; Sukanta Sen; Arunava Biswas; Tapan Kumar Barman; Santanu Kumar Tripathi

    2015-01-01

    Aim: Despite having better tolerability and a wide range of clinical applications over other antidepressants, selective serotonin reuptake inhibitors (SSRIs) are also known to be associated with serious adverse effects like suicidal ideation on chronic use. The present study had explored the impact of the chronic use of sertraline, an SSRI, on the behavioral changes in Wistar albino rats. Materials and Methods: The study was conducted on 30 Wistar albino rats of either sex; divided into f...

  20. HAIR GROWTH POTENTIAL OF EVOLVULUS ALSINOIDES LINN. PLANT EXTRACT IN ALBINO RATS

    OpenAIRE

    Bhaiji Amrita; Patil Umesh Kumar; Dave Suchi; Jain Arvind; Sahoo Himanshu Bhusan

    2012-01-01

    Evolvulus alsinoides Linn. (Convolvulaceae) is traditionally used for its hair growth promoting activity in rural community of Indian sub-continent. Studies were therefore carried out to evaluate petroleum ether and methanolic extracts of Evolvulus alsinoides for their effect on hair growth in albino rats. The extracts were incorporated into oleaginous base and applied topically on shaved denuded skin of albino rats for thirty days. The time required for hair growth initiation and completion ...

  1. Shewanella algae en un paciente con diarrea crónica. Primer caso en Costa Rica

    Directory of Open Access Journals (Sweden)

    Erick Molina- Guevara

    2009-09-01

    Full Text Available Se presenta el caso de un paciente masculino, vecino de Pavas-San José, con historia de diarrea crónica. En el coprocultivo se identificó Shewanella algae. Casos de infección en humanos por esta bacteria son raros y se han encontrado, predominantemente localizadas, en piel, oídos y tejidos blandos con o sin bacteremia, en la mayoría de los cuales existe el antecedente de contacto con ambientes marinos. Shewanella algae es sensible a aminoglicósidos, carbapenemes, eritromicina y quinolonas, pero resistente a penicilinas. La sensibilidad a ampicilina y cefalosporinas es variable. Nuestro paciente fue tratado con cefalexina y tuvo una respuesta satisfactoria al mismo, con cese de los síntomas. De acuerdo con nuestro conocimiento este el primer caso documentado, en Costa Rica, de infección gastrointestinal por esta bacteria.

  2. CHILE'S RUSH TO FREE TRADE AGREEMENTS El frenesí de Chile por los Tratados de Libre Comercio

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    LESLIE WEHNER

    2011-01-01

    Full Text Available This article analyses the reasons for Chile's aggressive Free Trade Agreement (FTA policy. Assessing both how the Chilean government has converged with the export sector and how the government has been able to co-opt, soften and divide those on the losing side of any FTA policy, are key to understanding Chile's vast number of FTAs. However, FTAs are also a constitutive part of a country's foreign policy, which converts these accords into a vehicle for the achievement of state goals dealing with economic issues and power configurations and expectations. It is the interplay between domestic groups' interests and the state's foreign policy goals that explain Chile's rush to FTAs.Este artículo analiza las razones que llevan a Chile a implementar una política agresiva de Tratados de Libre Comercio (TLC. Para comprender el porqué del frenesí y del número de acuerdos se evalúa cómo el gobierno de Chile logra converger con el sector exportador, y cómo coopta, divide y disminuye a los grupos perdedores de esta política. Sin embargo, los TLC son además parte de la política exterior de un país; lo que hace de estos acuerdos un vehículo para alcanzar objetivos estratégicos para el Estado. Es la interrelación entre los intereses de grupos domésticos y los objetivos de política exterior del Estado los que explican el porqué del frenesí de Chile por alcanzar un alto número de TLC.

  3. El Camino de Paikín: un acercamiento a los grupos mocoví del Chaco a través del tratado de 1774

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    Florencia Nesis

    2008-07-01

    Full Text Available En 1774 y dentro de un programa que intentaba establecer paces con los grupos indígenas del Chaco se produjo el encuentro entre Jerónimo Matorras, gobernador del Tucumán y Paikín, líder Mocoví. Este encuentro, que tuvo lugar dentro del territorio chaqueño, dio lugar a la firma de un tratado que buscaba regular las relaciones entre ciertos grupos indígenas y el sector colonial La publicación de este tratado en varias obras de recopilación desde principios del siglo XX ayudó a crear una imagen acerca del comienzo del dominio político y territorial de los indígenas por parte de la sociedad hispanocriolla. En el presente trabajo proponemos releer el tratado de 1774 dentro del conjunto mayor de fuentes que se produjeron en torno a estas negociaciones para adentrarnos en las estrategias y prácticas políticas desplegadas, la modificación de las relaciones de alianza y enemistad y las condiciones de posibilidad de acción de cada uno de los sectores implicados.In 1774, in a program that tended to make peace with the Chaco aboriginal groups, a meeting was held between Jerónimo Matorras, governor of Tucumán, and Paikín, mocoví leader. This meeting, that took place inside the indigenous territory, gave rise to a treaty that looked to regulate different aspects of the interethnic relationships. The diffusion of this treaty in several compilation publications since the beginning of the XX century helped to create a concept of the colonial political and territorial domain over the indigenous groups. In this paper we propose to rethink the 1774 treaty putting it in relation with other documents that were also made on the basis of these negotiations. Through this analysis, we expect to delve into the political strategy, the change in the relationships of friendship and enmity between the indigenous groups and different colonial agents, and the action possibilities of each one.

  4. Erythropoietin-Like Effects of Dihydroartemisinin in Wistar Albino Rats

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    Utoh-Nedosa U. Anastasia

    2011-01-01

    Full Text Available Artemisinin drugs were active during the intra-erythrocytic stage of malaria parasite infection. The activity of artemisinin and synthetic endoperoxides was related to their interaction with heme. The electrophillic intermediate formed from artemisinin in the presence of heme alkylates the protein portion of hemoglobin preferentially to the heme portion. Problem statement: Since there might be an interaction between artemisinin and the heme of the blood, we studied the effects of 5-day and 7-day oral Dihydroartemisinin (DHA treatments with 5 dosage regimens of dihydroartemisinin on the blood and six vital organs of Wistar albino rats. Approach: The dosages of DHA tested on 5 test adult Wistar albino rats (weight = 106-140 grams were 1, 2, 60 or 80 mg Kg-1 rat weight of DHA by oral intubation for 5 or 7 days. Four rats of similar weight which served as controls in each experiment were given distilled water equivalents of the administered doses of DHA. Another group of 5 test rats and four control rats (weight 75-90 gms were given 1 mg kg-1 rat weight of DHA or distilled water for 5 or 7 days and were allowed to rest for one week after which the treatment was repeated. Results: The findings of the study showed that Dihydroartemisinin (DHA had erythropoietin-like properties. In the study DHA produced dose, repetition and time dependent statistically significant increases in the Packed Cell Volume (PCV (PConclusion: This result suggested that the administered DHA inhibited its own stimulated statistically significant increases in the PCV and the WBC of the treated rats through an inhibitory (negative feed-back effect. The structure and composition of the blood cell types like the presence of large numbers of reticlocytes and left-shifted neutrophils in the blood samples of 5-day DHA -treated rats but not in those of 7-day DHA treated rats indicated that new haemopoiesis was actively going on in the first 5 days of DHA treatment but had slowed down

  5. Biological dosimetry of patients with differenced carcinoma of thyroid treated with Iodine-131; Dosimetria biologica de pacientes con carcinoma diferenciado de tiroides tratados con Iodo-131

    Energy Technology Data Exchange (ETDEWEB)

    Vallerga, M. B.; Rojo, A.M.; Taja, M.R.; Deluca, G.; Di Giorgio, M. [Autoridad Regulatoria Nuclear Av. Del Libertador 8250 (C1429BNP). Buenos Aires (Argentina); Fadel, A. [Hospital General de Agudos Dr. Carlos Durand Av. Diaz Velez 5044. Buenos Aires (Argentina); Cabrejas, M.; Valdivieso, C. [Hospital de Clfnicas Jose de San Martin Av. Cordoba 2351 (CP1120). Buenos Aires (Argentina)]. e-mail: mvallerg@cae.arn.gov.ar

    2006-07-01

    The administration of I-131 to patient with Differentiated Thyroid Carcinoma (CaDiT) it is used inside the therapeutic outline as later step to the thyroidectomy. However, the good activity to give is of difficult determination due to factors such as, the variability in the capacity of tumoral reception of the I-131, distribution of the pharmaceutical, physiologic status, other associate pathologies, grade of advance of the illness, and previous treatments. Additionally, the activity to administer is dependent of the dose of tolerance in the healthy tissues; superior dose to 2 Gy in bone marrow, its could drive to myelotoxicity. At the moment, the form more extended of administration it is the empiric prescription that considers clinical parameters and of laboratory for their determination. Presently work, the protocol of applied treatment incorporates the evaluation for internal dosimetry and biological dosimetry to estimate absorbed dose in bone marrow. The biological estimate of the dose of these patients is based on the quantification of chromosomal aberrations whose frequency is referred to a curve-dose response in which the lymphocytes is irradiated in vitro with I-131, allowing to determine the in vivo dose to the patient's circulating lymphocytes. The objective of the present work is to determine the applicability of different cytogenetic essays in the estimate of the absorbed dose to the whole body or specific organs. Three patients were evaluated with CaDiT. Their treatment protocol consisted on a tracer administration of radioactive iodine of 74 - 111 MBq (2 - 3 mCi) and a therapy 7,4 - 11,1 GBq (200 - 300 mCi). Previous to the tracer administration and 8 days post-therapeutic administration took samples of veined blood that were evaluated by biological dosimetry by means of the application of the techniques: conventional cytogenetic Micronucleus and FISH (Hybridization in situ by Fluorescence). Starting from the frequencies of observed chromosomal aberrations it was considered absorbed dose to whole body. The obtained doses were compared by the different biological methods used. The evaluation by internal dosimetry of the data obtained tracer post-activity allowed to personalize the activity of I-131 to administer, starting from physical-mathematical models that consider the particular biokinetics of each patient (MIRD methodology). The doses estimated by the used biological dosemeters were consistent among them. It was discussed its scopes and limitations to be applied in the validation of the dosimetric estimation based on models, in order to administer a therapeutic dose protecting the patient of the adverse effects of the internal radiotherapy in organs that are not target of the same one. The acquired experience is considered of utility to give answer in cases of radioiodine incorporation in occupationally exposed personnel. (Author)

  6. Hematological and Histological Response of Wister Albino Rat Rattus norvegicus a Dietary Supplement of Seaweed Diet Gracilaria edulis

    OpenAIRE

    Anbalagan, T

    2009-01-01

    A dietary supplementation of seaweed Gracilaria edulis haematological and histological responseof albino rat Rattus norvegicus .The blood protein, cholesterol, albumin, calcium, phosphorus and urea of theseaweed feed albino rats having an increased tendency during the experimentation when compared with controlrats. Its note mostly that the experimental rat showing a decreasing level of glucose when compared withcontrol rats. The oral picture of the haematological change of albino rat fed with...

  7. El tratado de Domingo de Andrade Excelencias, antigüedad y nobleza de la arquitectura (1695 y la tratadística de su tiempo

    Directory of Open Access Journals (Sweden)

    Fernández Gasalla, Leopoldo

    2008-12-01

    Full Text Available Domingo de Andrade, chief architect of Santiago de Compostela’s Cathedral between 1677 and 1710, was de foremost artistical personality of his generation in Galicia. He also became a new kind of artist, capable of combining the practise of his art in the most brilliant way with the elaboration of theoretical approaches to it. This paper analyzes the origin of his treatise “Excelencias, Antigüedad y Nobleza de la Arquitectura” conceptual structure, as well as its relations with the previous and contemporary apologetical literature.El arquitecto Domingo de Andrade, maestro de obras de la catedral de Santiago, además de actuar como principal figura de su generación en Galicia, encarnó un nuevo tipo de artista capaz conjugar la práctica más brillante de su disciplina con la elaboración de planteamientos teóricos. Esa nueva dimensión abría las puertas del mundo de las Artes Liberales, para él y sus colegas más distinguidos. El presente artículo analiza el origen de la estructura conceptual del tratado Excelencias, Antigüedad y Nobleza de la Arquitectura, así como sus vínculos con la literatura apologética precedente y contemporánea.

  8. Antiarthritic activity of Vernonia amygdalina in albino rats

    Institute of Scientific and Technical Information of China (English)

    Georgewill OA; Georgewill UO

    2009-01-01

    Objective:To evaluate the antiarthritic activity of water extract of leaves of Vernonia amygdalina(V.A.)on arthritis induced model of rats.Methods:Arthritis was induced in male albino Wister rats by injection of cro-ton oil (0.1 mL)into the left foot pad of the animals.Treatment with V.A.at 200 and 400 mg/kg and stand-ard Indomethacin (0.3 mg/kg)was started on the same day and continued up to the 12th day.The paw vol-ume was measured on the 1st,5th,12th and 21st day,respectively for both the paws and anti-arthritic activity was evaluated.Results:The extract of V.A.produced reduction in the inflammation of the paw due to croton oil.The antiarthritic action started on the 5th day and continued till the 12th day and the activity was compara-ble to that of the standard on both days.V.A.significantly inhibited adjuvant induced arthritis and had signifi-cant ant-inflammatory effect (P <0.05).Conclusion:This report therefore clearly showed that V.A.signifi-cantly inhibited adjuvant induced arthritis in rats as it significantly reduced the paw volume on the 12th day and may explain the effectiveness of this plant when used in the tropics for the treatment of arthritis.

  9. Estudio comparativo de las maloclusiones de clase III tratadas con y sin cirugía

    OpenAIRE

    Martínez Asúnsolo, Pascual

    2014-01-01

    El objetivo de la presente tesis fue determinar si existen diferencias en la inclinación de los incisivos superiores e inferiores en pacientes de clase III tratados con cirugía o únicamente con “camuflaje ortodóncico”, así como su repercusión en la relación esquelética final. Para ello se realizó un estudio clínico comparativo y retrospectivo en la unidad docente de Ortodoncia del departamento de Estomatología de la Universidad de Valencia. La muestra consistió en 56 pacientes que cump...

  10. Fracturas del húmero proximal: su tratamiento con clavos bloqueados proximales

    OpenAIRE

    Arenas Planelles, Antonio; D'Arrigo, A.; Arenas Miquélez, A.; Duart, J.

    2012-01-01

    Se presentan 27 casos de fractura de húmero proximal tratados mediante osteosíntesis con clavo proximal bloqueado. Los resultados fueron buenos en la mayor parte de los pacientes, con un dolor medio de 11,67/15 en la cotación cifrada de Constant, una fuerza de 14/25 puntos y una movilidad de 20,52/40 puntos. Las complicaciones más importantes fueron el conflicto subacromial (29,6%), la consolidación viciosa de la fractura en varo (29,6%) y la protrusión de los tornillos de bloqueo...

  11. Tratamiento de las fracturas diafisarias de húmero mediante osteosíntesis con placa

    OpenAIRE

    Zamora Rodríguez, J. M.; Modrego Aranda, Francisco Javier; Seral García, Belén; Seral Iñigo, Fernando

    2002-01-01

    Hemos tratado 22 facturas agudas diafisarias de húmero mediante reducción abierta y fijación con placa AO entre 1991 y 1999. Todas las fracturas excepto una consolidaron en un plazo medio de 94 días. De acuerdo con el criterio de Brumback los resultados fueron excelentes o buenos en el 90% de los casos. La complicación postoperativa más importante fue la parálisis del nervio radial en 3 casos; todos se recuperaron espontáneamente en un plazo medio de 108 días. La fijación interna mediante pla...

  12. Modelado farmacocinético de ciclofosfamida en pacientes con cáncer de mama.

    OpenAIRE

    Llopis García, Mª Carmen

    2009-01-01

    El objetivo principal es establecer un modelo estructural farmacocinético poblacional, en pacientes con cáncer de mama de alto riesgo tratados con ciclofosfamida a dosis altas, para predecir su respuesta individual.Los objetivos Secundarios son explorar mecanismos fisiológicos condicionantes de la autoinducción metabólica de ciclofosfamida. Detección de subpoblaciones de pacientes a través de parámetros de eliminación de ciclofosfamida. Plantear la influencia de covariables, a través del anál...

  13. Chronic alcoholism-mediated metabolic disorders in albino rat testes

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    Shayakhmetova Ganna M.

    2014-09-01

    Full Text Available There is good evidence for impairment of spermatogenesis and reductions in sperm counts and testosterone levels in chronic alcoholics. The mechanisms for these effects have not yet been studied in detail. The consequences of chronic alcohol consumption on the structure and/or metabolism of testis cell macromolecules require to be intensively investigated. The present work reports the effects of chronic alcoholism on contents of free amino acids, levels of cytochrome P450 3A2 (CYP3A2 mRNA expression and DNA fragmentation, as well as on contents of different cholesterol fractions and protein thiol groups in rat testes. Wistar albino male rats were divided into two groups: I - control (intact animals, II - chronic alcoholism (15% ethanol self-administration during 150 days. Following 150 days of alcohol consumption, testicular free amino acid content was found to be significantly changed as compared with control. The most profound changes were registered for contents of lysine (-53% and methionine (+133%. The intensity of DNA fragmentation in alcohol-treated rat testes was considerably increased, on the contrary CYP3A2 mRNA expression in testis cells was inhibited, testicular contents of total and etherified cholesterol increased by 25% and 45% respectively, and protein SH-groups decreased by 13%. Multidirectional changes of the activities of testicular dehydrogenases were detected. We thus obtained complex assessment of chronic alcoholism effects in male gonads, affecting especially amino acid, protein, ATP and NADPH metabolism. Our results demonstrated profound changes in testes on the level of proteome and genome. We suggest that the revealed metabolic disorders can have negative implication on cellular regulation of spermatogenesis under long-term ethanol exposure.

  14. Immunomodulatory Activity of Abutilon Indicum linn on Albino Mice

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    N. L. Dashputre

    2010-04-01

    Full Text Available Purpose: To study the immunomodulatory activity of aqueous and ethanol extracts of leaves of Abutilon indicum Linn. (Family: Malvaceae on albino mice. Methods: The ethanolic and aqueous extract of leaves of Abutilon indicum was administered orally at the dosage levels of 200 mg/kg/day and 400 mg/kg/day body weight in mice. The assessment of immunomodulatory activity on specific and non-specific immunity were studied by heamagglutination antibody (HA titer, delayed type hypersensitivity (DTH, neutrophil adhesion test and carbon clearance test. In order to induced immunosuppresion in mice by using cyclophosphamide (100 mg/kg/day, p.o. and levamisole (50mg/kg/day, p.o. used as immunostimulating agents. Results: Oral administration of A. indicum showed a significant increase in the production of circulating antibody titre in response to sheep red blood cells (SRBCs. A significant (p<0.01 increase in both primary and secondary HA titre was observed when compared to control group, whereas in cyclophosphamide treated group A. indicum showed ignificant (p<0.01 increase in HA titre. A. indicum showed ignificantly (p<0.01 potentiated the DTH reaction by facilitating the footpad thickness response to SRBCs in sensitized mice. Also A. indicum evoked a significant (p<0.01 increase in percentage eutrophil adhesion to nylon fibers and phagocytic activity.Conclusion: The study demonstrates that A. indicum triggers both pecific and non-specific responses to a greater extent. The study comprised the acute toxicity and preliminary phytochemical screening of A. indicum. From the results obtained and phytochemical studies the immunostimulant effect of AI could be attributed to the flavonoid content.

  15. Un regimen sanitatis contra la peste: el tratado del licenciado Vázquez

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    de la Peña Barroso, Efrén

    2012-12-01

    Full Text Available The regimina pestis or plague treatises are the main literary genre where late medieval doctors reflected their medical concern about plague and pestilences. These medical texts, in which some practical recommendations were given to people to avoid and/or cure the effects of epidemic disease of high letality, were developed since the outbreak of the epidemic in 1348. The text now presented is a treatise on plague written by the «licenciado Vázquez», a converso from the archbishopric of Toledo who was tried by the Inquisition at the beginning of the 16th Century.Los regimientos o tratados contra la peste o pestilencia son expresión del modo en que los médicos universitarios bajomedievales hicieron frente a la enfermedad epidémica de alta letalidad. Estos textos médicos, que consistían en un repertorio más o menos amplio de recomendaciones prácticas para prevenir y/o tratar dicha enfermedad, experimentaron un notable desarrollo a partir de la peste negra de 1348. El texto que se ofrece a continuación es un tratado inédito contra la peste escrito por el licenciado Vázquez, un judeoconverso toledano que fue procesado por el Tribunal de la Inquisición a principios del siglo XVI.

  16. EL SISTEMA EUROPEO DE DERECHOS FUNDAMENTALES TRAS LA ENTRADA EN VIGOR DEL TRATADO DE LISBOA

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    Lorenzo Martín-Retortillo Baquer

    2011-07-01

    Full Text Available Resumen: En 1947 se pusieron las bases de lo que llegaría a ser la Unión Europea, a modo de organización comercial para sectores concretos, complejo que iría creciendo, ampliándose los fines y la organización, a la par que se fraguaba un complejo ordenamiento jurídico. Se hizo necesario alcanzar una declaración de derechos que incluyera los modernos derechos sociales. En el trabajo se estudia la compleja historia de la obtención de la declaración, la “Carta de Derechos Fundamentales de la Unión Europea”, que, al fin, entraría en vigor el 1.XII.2009, a la par que el último de los Tratados de la Unión, el Tratado de Lisboa.Abstract: The European Union was founded in 1947 as a concrete trade organization but it started to grown. The aims and the organization had increased and in the meantime a complex law system was set up. It was convenient to get a solid bill of rights including the modern social rights. The paper studies the complicate story of how to obtain the bill of rights –the “Carta of Fundamentals Rights of the European Union”- which formally came into effect the 1.XII.2099 at the same time that the last Treaty of the Union, the Treaty of Lison.

  17. Ventilación mecánica no invasiva en el paciente con orden de no intubación

    OpenAIRE

    Soler Barnés, Juan Alfonso

    2009-01-01

    INTRODUCCIÓN: La Ventilación Mecánica No Invasiva (VMNI) se está convirtiendo en la medida inicial de soporte respiratorio en la mayoría de etiologías condicionantes de Insuficiencia Respiratoria Aguda (IRA). Sin embargo, su uso es controvertido en los pacientes con “orden de no intubación” (ONI). METODOLOGÍA: Estudio prospectivo y observacional realizado durante 10 años en una UCI sobre pacientes con IRA, con o sin ONI, tratados con VMNI. El seguimiento fue de 1 año. RESULTADOS: Se reclutaro...

  18. Tratamiento de la osteoporosis grave con teriparatide

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    Marcelo A. Sarli

    2013-10-01

    Full Text Available El objetivo de este trabajo retrospectivo fue evaluar el tratamiento de la osteoporosis grave con teriparatide (PTH y comparar nuestros resultados con los publicados en la literatura médica. Se incluyeron cuarenta y seis pacientes, cuarenta y dos mujeres y cuatro varones, edad: 69.15 ± 9.43 años. Seis eran vírgenes de tratamiento y cuarenta tratados previamente con bisfosfonatos. Treinta y dos pacientes habían tenido 93 fracturas de las cuales 86 vertebrales. Cuarenta y seis recibieron PTH 6 meses, 29 pacientes durante 12 meses y 20 completaron los 18 meses sugeridos. La densidad mineral ósea (DMO de columna lumbar aumentó significativamente desde el primer control a los 6 meses (p < 0.0001. La DMO de cuello de fémur alcanzó un incremento significativo al final del tratamiento (p = 0.002. La osteocalcina aumentó significativamente al mes, seguido por el ß crosslaps (beta-CTx, prueba en suero al tercer mes y la fosfatasa alcalina ósea, regresando los marcadores de recambio óseo a niveles basales a los 18 meses. Las calcemias y las calciurias no se modificaron significativamente, pero 8 pacientes tuvieron hipercalcemias leves y tres hipercalciurias asintomáticas. El tratamiento fue bien tolerado y no se registraron efectos adversos graves que requirieran suspender el tratamiento. En conclusión, la PTH es una alternativa útil y segura para el tratamiento de la osteoporosis grave. Nuestros resultados concuerdan con los previamente publicados en la literatura médica.

  19. Correlation of body weight and other morphometric measurements in Albino rats (Rattus Norvegicus

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    Bruno Ikenna Aguh

    2013-03-01

    Full Text Available Relationship between body weight and other morphometric measurements in Albino rats (Rattus norvegicus was investigated. Morphometric data such as body weight (BDYWT, tail length (TL, body length from nose to anus (BLNA, body length from nose to tail tip (BLNT, tail circumference (TC, tail diameter (TD, and ear length (EL were collected from fifty live Albino rats involving 28 females and 22 males. The collected data were evaluated using regression analysis, correlation and independent-sample t-test. There was high significant (P r2 values ranging from 0.264 to 0.81. Regression analysis with high r2 value could be exploited in predicting many morphometric traits with great accuracy with the body weight serving as the explanatory or predictor variable. This research also suggested that male and female Albino rats have very similar morphometric characters as the results of independent-samples t-test showed.

  20. Hypoglycemic effect of Brassica juncea (seeds) on streptozotocin induced diabetic male albino rat

    Institute of Scientific and Technical Information of China (English)

    T Thirumalai; S Viviyan Therasa; EK Elumalai; E David

    2011-01-01

    Objective: To evaluate the hypoglycemic effect of Brassica juncea (seeds) on streptozotocin induced diabetic male albino rats. Methods: Hypoglycemic activity of Brassica juncea (seeds) aqueous extract at a dose of 250, 350 and 450 mg/kg body weight was evaluated. Adult male Swiss albino rats of six numbers in each group was undertaken for study and evaluated. Results: The serum insulin levels were recorded a significant depletion in all groups, short term as well as long term diabetic animals, when compared to that of normal animals. A significant dosage dependent augmenting effect of the seed extract on the serum insulin was recorded in both short term as well as long term groups. Conclusions: The aqueous seed extract of Brassica juncea has potent hypoglycemic activity in male albino rat.

  1. en tratamiento con antipsicóticos

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    A. González Padrón

    2007-01-01

    Full Text Available La intensidad y la evolución de la esquizofrenia dependen de la alteración de determinados centros neuronales y de la interacción entre la gravedad de tales alteraciones y las fluctuaciones de diversos neurotransmisores y neuromoduladores, entre ellos, la dopamina. Quizás debido a esta complejidad y heterogeneidad tanto en su causa como en su evolución, se dan casos de pacientes tratados con antipsicóticos, fisiológicamente estabilizados y de los que no se espera una evolución desfavorable que sufren un fallecimiento inesperado. En este sentido, se considera un caso de muerte súbita en un paciente que padecía hipertensión arterial, diabetes mellitus y esquizofrenia hebefrénica en tratamiento con tioridazina, sustancia que es determinada mediante cromatografía gaseosa acoplada a espectrometría de masas (GC-MS detectándose la presencia de tioridazina en una concentración de 2,392 mg/L de sangre. Estudiando dicho caso y teniendo en cuenta otros similares se aportan consideraciones que pueden ser de utilidad en la evaluación de estos agentes terapéuticos.

  2. Legitimidad y finalidad de los capítulos de propiedad intelectual en los tratados de libre comercio (TLC)

    OpenAIRE

    Susy Frankel

    2011-01-01

    Una visión analítica de la realidad actual permite apreciar un auge de los Tratados de Libre Comercio, mientras se presenta un estancamiento en las negociaciones multilaterales de comercio. Si bien la negociación de los TLC no se limita a los países desarrollados, los negociados por los países en desarrollo no tienden a contemplar mejoras en los estándares de propiedad intelectual. Algunos de los capítulos relativos a la propiedad intelectual incluidos en los Tratados de Libre Comercio simple...

  3. La consolidación de una nueva estrategia en las relaciones entre la Corona de Aragón y el Magreb Hafsída: el Tratado de 1403 y sus perspectivas mercantiles

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    López Pérez, Mª Dolores

    2010-12-01

    Full Text Available The political situation in the Kingdom of Tunis had a decisive influence on the targets and failures of its diplomatic and commercial links with the European powers. After a long period marked by successive agreements, the old objectives of the Crown of Aragon concerning the tax system were to be recognized in the agreement achieved in 1360, although that agreement is not achieved in practice enforce that claim. The strengthening of the Hafsid authority during the last decades of 14th Century opened a period of veiled confrontation. The increasing of the pirate actions, which culminated with the punishment expeditions on seaports of Maghreb, were an evidence for this confrontation. The agreement of 1403 ended up the hostilities and opened a new political strategy within the relationship between Crown of Aragon and Hafsid Maghreb.

    La coyuntura política del reino de Túnez repercutió de forma decisiva sobre las aspiraciones y fracasos de sus relaciones diplomáticas y comerciales con las potencias europeas. Tras un periodo prolongado jalonado por acuerdos sucesivos, las viejas pretensiones tributarias de la Corona de Aragón alcanzarán a ser reconocidas en el tratado suscrito en 1360, aunque aquel acuerdo no conseguirá hacer efectiva en la práctica dicha reclamación. El fortalecimiento del poder de los Hafsíes en las últimas décadas del siglo XIV reabre un periodo de confrontación velada con la intensificación de las actividades corsarias, que culminan en sendas expediciones de castigo sobre puertos magrebíes. El tratado de 1403 pondrá fin a dichas hostilidades y reabrirá una nueva estrategia en las relaciones con el Magreb Hafsída.

  4. Antidiarrhoeal efficacy ofMangifera indica seed kernel on Swiss albino mice

    Institute of Scientific and Technical Information of China (English)

    Rajan S; Suganya H; Thirunalasundari T; Jeeva S

    2012-01-01

    Objective:To examine the antidiarrhoeal activity of alcoholic and aqueous seed kernel extract of Mangifera indica (M. indica) on castor oil-induced diarrhoeal activity inSwiss albino mice.Methods:Mango seed kernels were processed and extracted using alcohol and water. Antidiarrhoeal activity of the extracts were assessed using intestinal motility and faecal score methods.Results:Aqueous and alcoholic extracts ofM. indica significantly reduced intestinal motility and faecal score inSwiss albino mice.Conclusions:The present study shows the traditional claim on the use of M. indica seed kernel for treating diarrhoea inSouthern parts of India.

  5. Changes of carbohydrate and protein metabolism in seedling leaves of a temperature-induced greenable albino mutant line W25 of rice

    Institute of Scientific and Technical Information of China (English)

    WU; SHUQingyao; XIAYingwu

    1998-01-01

    W25 is a low-temperature sensitive albino mutant line, Temperature not only controls the albino phenotype expression of W2o, but also determines whether it could survive, When the temperature is lower than 25℃. the leaves of W25 shows complete albino, but they exhibits normal green when temperature is higher than 30℃

  6. Desigualdades territoriales en México derivadas del tratado de libre comercio de América del Norte

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    Javier Delgadillo Maclas

    2008-04-01

    Full Text Available La instrumentación del Tratado de Libre Comercio de América del Norte (TLCAN a partir del año 1994 consolidó una etapa de libe ral ización económica iniciada en México a partir de 1982. La sistemática operación del TLCAN en los distintos sectores de la economía (incorporados a este acuerdo comercial se vio al mismo tiempo acompañada de efectos territoriales favorables en algunos casos, y de dimensiones críticas para un número importante de regiones y estados que componen la federación mexicana. Después de 14 años de su inicio, en este trabajo se analizan los procesos de reestructuración espacial desde entonces generados, las disparidades regionales asociadas al nuevo escenario internacional, y se da cuenta de las relaciones económicas que contraponen a la etapa actual del modelo neoliberal imperante con aquellas otras formas tradicionales de organización excluidas y que aún mantienen en México buena proporción de espacios socialmente marginadosThe coming into force of the North American Free Trade Agreement (NAFTA from 1994 consolidated a phase of Mexican economic liberalization that had begun in 1982. The systematic operationalization of the NAFTA in different sectors of the economy (incorporated into this commercial agreement was also accompanied by favorable spatial impacts in some cases, and unfavorable impacts for a significant number of regions and states of the Mexican federation. Fourteen years on, this article analyzes the processes of spatial restructuring that have been generated, the regional disparities associated with the new international scenario, and explains the economic relations that run in opposition to the current stage of the dominant neoliberal model, which has excluded other traditional forms of organization and has kept many areas of Mexico in a condition of social marginalization

  7. Convulsive liability of bupropion hydrochloride metabolites in Swiss albino mice

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    McMahon Louis

    2008-10-01

    Full Text Available Abstract Background It is known that following chronic dosing with bupropion HCl active metabolites are present in plasma at levels that are several times higher than that of the parent drug, but the possible convulsive effects of the major metabolites are not known. Methods We investigated the convulsive liability and dose-response of the three major bupropion metabolites following intraperitoneal administration of single doses in female Swiss albino mice, namely erythrohydrobupropion HCl, threohydrobupropion HCl, and hydroxybupropion HCl. We compared these to bupropion HCl. The actual doses of the metabolites administered to mice (n = 120; 10 per dose group were equimolar equivalents of bupropion HCl 25, 50 and 75 mg/kg. Post treatment, all animals were observed continuously for 2 h during which the number, time of onset, duration and intensity of convulsions were recorded. The primary outcome variable was the percentage of mice in each group who had a convulsion at each dose. Other outcome measures were the time to onset of convulsions, mean convulsions per mouse, and the duration and intensity of convulsions. Results All metabolites were associated with a greater percentage of seizures compared to bupropion, but the percentage of convulsions differed between metabolites. Hydroxybupropion HCl treatment induced the largest percentage of convulsing mice (100% at both 50 and 75 mg/kg followed by threohydrobupropion HCl (50% and 100%, and then erythrohydrobupropion HCl (10% and 90%, compared to bupropion HCl (0% and 10%. Probit analysis also revealed the dose-response curves were significantly different (p 50 values of 35, 50, 61 and 82 mg/kg, respectively for the four different treatments. Cox proportional hazards model results showed that bupropion HCl, erythrohydrobupropion HCl, and threohydrobupropion HCl were significantly less likely to induce convulsions within the 2-h post treatment observation period compared to hydroxybupropion HCl. The

  8. Impact of oxidative stress on pregnancy outcome in albino rats

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    R.S. Al-Naemi

    2012-01-01

    Full Text Available Accumulative reports documented that oxidative stress is implicated in many human and animal diseases. However, the reports concerning the effect of oxidative stress on pregnancy outcome are limited and scarce. The objective of this study was to determine the impact of oxidative stress on pregnancy outcome and to assess the antioxidant effect of vitamin C and E on oxidative stress parameters in blood and placental tissue samples in experimental pregnant animals model exposed to oxidative stress. Wister Albino rats were used in this work to investigate the effects of oxidative stress exposure (addition of H2O2 to the drinking water on pregnancy outcome. Rats were divided into 5 groups, as follows: Group I (included 7 normal pregnant rats which served as control group. Group II (exposed to 1 % H2O2 included 7 pregnant rats, the rats were allowed to become pregnant and received (1% H2O2 in drinking water from day 7th till the day 19th of pregnancy. Group III (exposed to 3% H2O2 included 8 pregnant rats. Same as group 2, but the rats were exposed to a higher concentration of H2O2 (3% in drinking water. Group IV (included 8 pregnant rats. Pregnant rats received vitamins C and E without induction of oxidative stress. Group V (included 8 pregnant rats.induction of oxidative stress by 1% H2O2 with vitamins supplementation in the pregnant rats. Serum total antioxidants capacity (TAC, serum and placental tissue oxidative stress biomarker; 8-iso prostaglandin F2α (8-Isoprostane were measured using specific ELISA kits. Also placental tissues of pregnant rats were isolated and put directly in 10% formalin prepared for histopathological examination. Results revealed a significant decrease in the median values of the body weight and total serum antioxidants capacity (TAC in groups II and III of rats compared with the control group. A significant higher median value of TAC obtained in the groups IV and V when compared with the control group. Significant higher

  9. Do conceito de propriedade no Segundo tratado sobre o governo de John Locke

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    Amaro de Oliveira Fleck

    2012-12-01

    Full Text Available Embora o Segundo tratado sobre o governo não tenha por intuito fundamentar o conceito de propriedade, mas sim o de mostrar o que torna um governo legítimo e em que circunstâncias o recurso à resistência não pode ser considerado ilegal, a teoria da propriedade como algo que se adquire mediante o trabalho, contida nesta obra, foi a concepção predominante acerca da propriedade ao longo da época moderna. O presente artigo busca expor os argumentos contidos nesta teoria, tanto contextualizando-os dentro da argumentação geral da obra quanto mostrando no que diferem das fundamentações da propriedade precedentes

  10. DERECHOS HUMANOS Y TRATADOS QUE LOS CONTIENEN EN EL DERECHO CONSTITUCIONAL Y LA JURISPRUDENCIA DE ECUADOR

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    Marco A. Morales Tobar

    2003-01-01

    Full Text Available El artículo analiza los derechos humanos en la Carta Fundamental del Ecuador y sus garantías, considerando la situación de los tratados internacionales en general y los derechos humanos en particular, estableciendo su procedimiento de incorporación, ubicando su posición entre las fuentes del derecho y considerando su aplicación por la jurisdicción constitucional ecuatoriana.The present article analizes Human Rights and their guarantees in the Constitution of Ecuador, considering the situation of international treaties in general and human rights in particular. Attention turns then to procedures for their incorporation, placing international treaties within the system of law and considering their application by the Ecuadorian constitutional jurisdiction.

  11. APLICACIÓN DE LOS TRATADOS INTERNACIONALES SOBRE DERECHOS HUMANOS EN LA JURISPRUDENCIA CONSTITUCIONAL PERUANA

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    Francisco José Eguiguren Praeli

    2003-01-01

    Full Text Available El artículo analiza las diferencias normativas en materia de derechos fundamentales o humanos en las Constitucionales de 1979 y 1993, realizando un análisis de la jurisprudencia del Tribunal Constitucional en la materia durante el imperio de la Carta Fundamental de 1993 y el impacto en el derecho interno de los tratados de derechos humanos y las resoluciones de la Comisión y la Corte Interamericana de Derechos Humanos.This article compares the norms on human rights of the Peruvian constitutions of 1979 and 1993, analyzing the opinions of the Constitutional Court since 1993 and the impact on internal law of human rights treaties and the decisions of the Inter-American Commission and Court on Human Rights.

  12. Sobre gnomos y gigantes: los tratados Grecorromanos y la igualdad soberana de los estados como ficción histórico-jurídica

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    Buis, Emiliano J.

    2011-12-01

    Full Text Available El presente trabajo inicialmente se aboca al estudio de los tratados que componen la Paz de Westfalia y su vínculo real con la construcción de la noción moderna de igualdad soberana de los Estados. A partir de este análisis crítico previo, la lección avanza sobre el estudio de las relaciones interestatales en el mundo griego y el romano, focalizándose principalmente en aquellos convenios celebrados antes de la era cristiana y en la necesidad de estos pueblos de recurrir a dichos instrumentos para fijar reglas de conducta previsibles. La hipótesis del trabajo, conforme a un vasto análisis de las situaciones propias del mundo antiguo, sugiere que aquellos Estados que se relacionaron en condiciones de desproporción de poder, siempre necesitaron acudir a un velo textual –convencional– de igualdad jurídica para disimular la real desigualdad de poder.

  13. Migración laboral México-Estados Unidos a veinte años del Tratado de Libre Comercio de América del Norte

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    Ana María Aragonés Castañer

    2015-01-01

    Full Text Available El fenómeno de la migración internacional de trabajadores está íntimamente relacionado con las desigualdades y las asimetrías del sistema capitalista y supone, además, la transferencia de plusvalía de los centros menos desarrollados hacia los polos industrializados o desarrollados. Si los países expulsores de migrantes se han ca-racterizado por aplicar políticas económicas que han ampliado los niveles de desempleo, la pau-perización de las condiciones laborales, la falta de apoyo al campo y el incremento del trabajo informal, en los países receptores los migrantes tienen una funcionalidad que se expresa en la diferencia existente entre el costo laboral unitario de los migrantes respecto de los trabajadores nativos. En este marco, el Tratado de Libre Co-mercio de América del Norte (1994 produjo una mayor subordinación económica de México hacia Estados Unidos y un crecimiento extraor-dinario de los flujos migratorios, en particular de la migración indocumentada, para los que no hubo ninguna protección ni cobertura legal.

  14. La PAC tras el Tratado de Lisboa : procesos legislativos ordinarios y actos de ejecución

    OpenAIRE

    Guillem Carrau, Javier

    2011-01-01

    El objetivo básico de este estudio es dejar patente que el Derecho agrario de la UE es especial y autónomo. Tras el Tratado de Lisboa, el procedimiento legislativo ordinario presupone una PAC más cercana al agricultor y al medio por el incremento de

  15. Tratamiento del síndrome de apnea obstructiva del sueño (SAOS) asociado a síndrome de hipoventilación-obesidad (SHO): presión positiva continua (CPAP) versus ventilación con presión positiva BI-nivel (BIPAP)

    OpenAIRE

    Hernández Vázquez, Julio

    2012-01-01

    OBJETIVOS. El objetivo principal es valorar la eficacia del tratamiento con BiPAP en comparación con CPAP sobre la disminución de la pCO2 en pacientes con SAOS y SHO, a los 3 y 12 meses del inicio de su aplicación. Los objetivos secundarios son comparar la evolución de los pacientes tratados con BiPAP con la de los tratados con CPAP en términos de mejoría de la pO2 diurna, cambios en la pruebas de función respiratoria (FEV1 y FVC), control de la somnolencia que conlleva el SAOS medida mediant...

  16. Therapeutic effects of Cassia angustifolia in a cadmium induced hepatotoxicity assay conducted in male albino rats

    Directory of Open Access Journals (Sweden)

    Muhammad Tahir Haidry

    2016-06-01

    Full Text Available The present study aims to investigate the therapeutic effects of Senna plant (Cassia angustifolia L. in a cadmium induced hepatotoxicity assay by evaluating the activity of alanine transaminase (ALT, aspartate transaminase (AST, alkaline phosphatase (ALP and total protein (TP in the albino rats’ serum. A total of 30 white albino rats were taken and divided into three groups; each group comprising ten rats. The group A was taken as a control group; group B was given cadmium chloride concentration of 5 mg/kg (body weight for 42 days; and group C was given cadmium chloride 5 mg/kg body weight for first 21 days and then extract of C. angustifolia 100 mg/kg (body weight was given for remaining 21 days. The analysis were performed twice i.e., on 21st day and 42nd day. Results illustrated that the concentration of cadmium was significantly elevated (P<0.05 at the levels of serum biochemical markers namely ALT, AST, ALP which lowered the protein levels in albino rats. Moreover, treatment with the standard extracts of C. angustifolia observed to reverse the effects of the cadmium significantly (P<0.05. It is concluded that the C. angustifolia had hepatoprotective effects and therapeutic potential against the cadmium induced hepatotoxicity in albino rats.

  17. Aphrodisiac and phytochemical studies ofCocculus hirsutus extracts in albino rats

    Institute of Scientific and Technical Information of China (English)

    SharanabasappaA Patil; SujayaM; SaraswatiB Patil

    2014-01-01

    Objective:To investigate thein vivo aphrodisiac activity of various extracts obtained from aerial partsCocculus hirsutus(C. hirsutus).Methods:We evaluated whether oral administration ofC. hirsutushas spermatogenic activity in male rats.Petroleum ether, chloroform and alcohol extract of aerial parts(stem and leaf) ofC. hirsutus were administered at the dose level of25 mg/100 g body weight to adult male albino rats for30 days.Results:The above said extracts have stimulated the spermatogenic activity and accessory reproductive organs performance in albino rats.Out of the three extracts administered, alcohol extract showed highly stimulant spermatogenic effects in mature male albino rats.Alcohol extract showed potent androgenic activity when treated in immatureAlbino rats.Males treated with the extract displayed more frequent and vigorous anogenital sniffing and mounting as compared to untreated animals.The increased spermatogenesis in extract treated groups was confirmed by change in histoarchitecture as evidenced by increase in number of spermatogonia, spermatocyte, spermatids and caudal spermatozoa.After subjecting to preliminary phytochemical screening, the alcohol extract showed positive tests for steroids, saponins, oils and fats, phenolic compounds and tannins.Conclusion:C. hirsutus exhibited remarkable increase in spermatogenic activity.These findings support the folk use of this plant as an aphrodisiac.

  18. Ostracism of an albino individual by a group of pigmented catfish.

    Science.gov (United States)

    Slavík, Ondřej; Horký, Pavel; Maciak, Matúš

    2015-01-01

    Physiological and behavioural constraints hinder albino individuals. Albino animals are rare in the wild; this trait is associated with easy detection by predators, non-native or damaged environments, and exclusively aphotic environments in total darkness. The social aspect of albinism is reported only for human beings, and the effect is distinguishable in time and space when social benefits, are used to a limited the extent. Thus far, the social consequences of albinism for animals remain unknown. We used socially established groups of the pigmented catfish, (Silurus glanis), to observe space and temporal distance detachment of albino specimens in laboratory conditions. The albino fish were separated at larger distances from the group than pigmented individuals with the same social status determined by familiarity, and this asymmetry also varied in time. Albinism-related ostracism results in a solitary existence, usually followed by enhanced predation risk. The motivation for an individual's exclusion from a group appears to be the avoidance of the predation risk that increases not only for an odd individual but also for conspecifics within a group. Our findings indicate a role for albinism in behavioural processes related to sociality in a group of conspecifics. PMID:26018869

  19. Generation of Albino Cynops pyrrhogaster by Genomic Editing of the tyrosinase Gene.

    Science.gov (United States)

    Nakajima, Keisuke; Nakajima, Taeko; Yaoita, Yoshio

    2016-06-01

    Albino animals are useful for in situ hybridization experiments that demonstrate gene expression in embryos and organs, for the immunological rejection of skin grafts transplanted to host animals, and to identify tissues with regenerative ability during limbs and retina regeneration processes. Cynops pyrrhogaster has extensive regenerating capacities. To facilitate regenerative research, in the present study, we produced albino C. pyrrhogaster using genomic editing. The DNA fragment containing part of the tyrosinase gene from C. pyrrhogaster was amplified using degenerate primers corresponding to evolutionarily conserved nucleotide sequences among several species, and the nucleotide sequence was determined. We designed a transcription activator-like effector nuclease (TALEN) that targets a candidate of the C. pyrrhogaster tyrosinase gene. Fertilized eggs were injected with TALEN mRNA, and albinos of C. pyrrhogaster were obtained. The results of the present study demonstrated that TALEN can be used effectively for genomic editing in C. pyrrhogaster and that the candidates of the tyrosinase gene that were cloned by us are essential for melanin synthesis. The albino newts created in the present study can be used as versatile experimental material. PMID:27268983

  20. Effect of Semecarpus anacardium fruits on reproductive function of male albino rats

    Institute of Scientific and Technical Information of China (English)

    ArtiSharma; PramodKumarVerma; V.RDixit

    2003-01-01

    Aim: To evaluate the effect of an ethanolic extract of Semecarpus anacardium fruits on spermatogenesis in albino rats. Methods: Male albino rats were fed with a 50 % ethanolic extract of Semecarpus anacardium fruit at 100 mg·kg-l·day-1, 200 mg·kg-l·day-1 and 300 mg·kg-1·day-1 for 60 days. Fertility test was performed after 60 days of treatment. Sperm motility and density were observed in the cauda epididymis. Biochemical and histological analyses of the blood and reproductive organs were done. Recovery of fertility was followed to evaluate the reversibility of drug action. Results: S. anacardium fruit extract administration resulted in spermatogenic arrest in albino rats. Thes perm motility and density was reduced significantly. The RBC and WBC counts, haemoglobin, haematocrit, blood sugar and urea were found to be within the normal range in the whole blood. The protein, cholesterol and glycogen in the testes and the fructose in the seminal vesicle were significantly decreased after the treatment. The fruit extract feeding caused marked reduction in the number of primary spermatocytes, secondary spermatocytes and spermatids.The number of mature Leydig cells was also decreased and degenerating cells increased proportionately. Conclusion:S. anacardium fruit extract causes spermatogenic arrest in albino rats. ( Asian J Androl 2003 Jun; 5: 121-124)

  1. Ostracism of an albino individual by a group of pigmented catfish.

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    Ondřej Slavík

    Full Text Available Physiological and behavioural constraints hinder albino individuals. Albino animals are rare in the wild; this trait is associated with easy detection by predators, non-native or damaged environments, and exclusively aphotic environments in total darkness. The social aspect of albinism is reported only for human beings, and the effect is distinguishable in time and space when social benefits, are used to a limited the extent. Thus far, the social consequences of albinism for animals remain unknown. We used socially established groups of the pigmented catfish, (Silurus glanis, to observe space and temporal distance detachment of albino specimens in laboratory conditions. The albino fish were separated at larger distances from the group than pigmented individuals with the same social status determined by familiarity, and this asymmetry also varied in time. Albinism-related ostracism results in a solitary existence, usually followed by enhanced predation risk. The motivation for an individual's exclusion from a group appears to be the avoidance of the predation risk that increases not only for an odd individual but also for conspecifics within a group. Our findings indicate a role for albinism in behavioural processes related to sociality in a group of conspecifics.

  2. Lipid Lowering Efficacy of Pennisetum glaucum Bran in Hyperlipidemic Albino Rats

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    I. Javed*, B. Aslam, M. Z. Khan1, Zia-Ur-Rahman, F. Muhammad and M. K. Saleemi1

    2012-05-01

    Full Text Available The objective of the study was to determine lipid lowering efficacy of Pennisetum (P glaucum (Pearl millet, locally known as bajra, bran in hyperlipidemia albino rats. Simvastatin, (Tablet survive®, was used as cholesterol lowering synthetic drug. The period of 0-15 days was considered as a lead-in period to induce hyperlipidemia with atherogenic diet in albino rats. P. glaucum bran at dose rate of 2, 4 and 6 g/kg BW showed lipid lowering efficacy in hyperlipidemic rats at post-treatment days 30, 45 and 60. At the level of 6 g/kg, P. glaucum bran was able to produce a significant (P<0.05 increase in HDL- cholesterol (47% and fall in other lipid profile parameters i.e. total lipids (41%, triglycerides(48%, total cholesterol (39% and LDL- cholesterol (55%. P. glaucum 6 g/kg also reduced total cholesterol in liver tissue and increased fecal bile acid secretion. The results of present study suggest that 6 g/kg P. glaucum bran and 0.6 mg/kg Simvastatin were equally effective in treating hyperlipidemia in albino rats. Moreover, the potency of P. glaucum for stimulating fecal bile acid secretion in albino rats may safely be conceived, at least, as a part of mechanisms for its antihyperlipidemic efficacy.

  3. Os Tratados de Polícia, fundadores da moderna saúde pública (1707-1856 Los Tratados de Policía, fundadores de la salud pública moderna (1707-1856 Treatises on Medical Police, founders of modern public health (1707-1856

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    Carlos Lousada Subtil

    2012-07-01

    Full Text Available A participação dos enfermeiros no movimento higienista é relativamente recente em relação aos momentos fundadores da moderna saúde pública, a que nos vamos referir. Para o enfermeiro de saúde pública contemporâneo é fundamental, no âmbito das suas atribuições e competências, analisar esses momentos à luz dum quadro conceptual que lhe permita esclarecer-se e estruturar a sua identidade profissional na construção do presente e no delinear do futuro. É objetivo deste trabalho fazer uma breve apresentação de alguns estudos sobre o tema e, sobretudo, analisar e discutir o «Tratado de Conservação da Saúde dos Povos», de Ribeiro Sanches (1756 e o «Tratado de Polícia Médica», de Freitas Soares (1818 que refletem os princípios da ciência de Polícia contidos na obra de Nicolas Delamare (1707, com recurso à metodologia de investigação histórica foucauniana. Aquelas obras ilustram bem a lenta passagem do modelo de governação corporativo para o estadualista, que se iniciou nos finais do Antigo Regime, e prosseguiu, com avanços e recuos, ao longo da monarquia constitucional inaugurada pela revolução de 1820.La participación de los enfermeros en el movimiento higienista es relativamente reciente con respecto a los momentos fundadores de la salud pública moderna a la cual vamos a referirnos. Para el enfermero actual de salud pública es fundamental, dentro del ámbito de sus atribuciones y competencias, analizar dichos movimientos a la luz de un marco conceptual que le permita aclarar y estructurar su identidad profesional en su construcción del presente y en el delinear de su futuro. El objetivo de este trabajo es realizar una breve presentación de algunos de los estudios sobre el tema y, sobre todo, analizar y discutir el «Tratado de Conservação da Saúde dos Povos», de Ribeiro Sanches (1756 y el «Tratado de Polícia Médica», de Freitas Soares (1818, que recogen los principios de la ciencia de Pol

  4. Conocimiento del médico acerca del tratado de libre comercio en el sector salud costarricense

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    Nancy Mesén-Arce

    2007-04-01

    Full Text Available Justificación: Al ser la salud un derecho en sí misma y tener relación recíproca con el crecimiento económico de un país, adquiere relevancia el análisis de las repercusiones del Tratado de Libre Comercio con EEUU (TLC en el sector salud costarricense. El objetivo de este trabajo es determinar el conocimiento de médicos trabajadores de la CCSS acerca de los posibles efectos del TLC sobre el sector salud. Metodología: Se elaboró un cuestionario compuesto por preguntas abiertas y cerradas, el cual se aplicó a 60 médicos, entre abril y mayo de 2006, en tres hospitales nacionales de la CCSS, específicamente: Hospital San Juan de Dios, Hospital "Dr. Rafael A. Calderón Guardia" y Hospital de las Mujeres "Dr.Adolfo Carit Eva". Resultados: De los sesenta médicos entrevistados, un 37% fueron mujeres y un 63% hombres. El 83% mencionó conocer el TLC, un 75% por los medios de comunicación y un 53% había sido informado acerca del contenido sobre propiedad intelectual. Los efectos sobre la salud más frecuentemente mencionados fueron: el acceso a los medicamentos genéricos (60%, la accesibilidad a los servicios de salud (50% y las oportunidades laborales (40%, solo un 15% no reconoció ningún fecto. Conclusión: Los médicos, como profesionales, como trabajadores de la CCSS y como consumidores deben conocer sobre los contenidos del TLC que pueden afectar su desempeño laboral. Este estudio demuestra que muchos de los entrevistados no tienen un adecuado conocimiento el TLC ni de sus implicaciones o efectos en el sistema de salud costarricense.Justification: Health is a human right by itself and it is related to the countries economic growth. One problem put forward by CAFTA has to do with its effects on the health services. The present study was undertaken to determine the knowledge of medical doctors regarding the possible effects of CAFTA on the health system and its repercussions on availability of generic medicines and the access to

  5. QUANTITATIVE AND HISTOCHEMICAL STUDY ON THE ADRENAL MEDULLA IN POST NATAL PERIOD OF ALBINO RAT

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    Wagieh k.Baiomy; Abdel-mawgood Anas; Mamdooh Ghaly; Ashraf M. Moustafa

    2009-09-01

    Full Text Available Background: The present work was based on the evaluation of histological, histochemical, and quantitative study on the adrenal medulla of the white albino rat in the different post natal age period. Material and methods:Sixty male albino rats were used in this study. The rats were classified to 4 main groups as follows: - Group one : One week old albino rats. - Group two: One month old albino rats. - Group three: Three months old albino rats. - Group four: Senile rats. Three main parameters were performed in this study, the first was the study of the morphological changes in the adrenal medulla in the different postnatal age groups. The second was concerned with the histochemical studies while the last parameter was the quantitative studies on the gland volume as well as its cellular count. These three parameters were performed by using different staining techniques. Results: The results showed that medullary cells in the early age groups were arranged in non-differentiated groups and become more differentiated in the older age groups. Both reticular and elastic fibers in the older age groups showed a definite increase especially at the region of corticomedullary zone. The different types of chromaffin cells were more observed at the old age groups. The concentration of ascorbic acid granules was more marked in the senile group. The quantitative changes were in the form of increased medullary volume especially in the old age. The number of chromaffin cells as well as the concentration of ascorbic acid contents was more noticed in the old age group. Conclusions: The differentiation of both divisions of the adrenal gland was not noticed in the early age groups. Cellular and fibrous differentiations were more seen in older age groups which may reflects an idea about the degree of gland maturation

  6. Comparative analysis of transcriptomes from albino and control sea cucumbers,Apostichopus japonicus

    Institute of Scientific and Technical Information of China (English)

    MA Deyou; YANG Hongsheng; SUN Lina; XU Dongxue

    2014-01-01

    The sea cucumberApostichopus japonicus is an important economic species in China. Its dorsal body wall color is commonly tawny, whereas its ventral surface is fawn. Albino sea cucumbers are rarely observed. In order to profile gene expression and screen albinism-related genes, we compared the transcriptome of albino samples with a control by 454 cDNA sequencing. We found that 6 539 identified genes on the basis of sequence similarity to known genes were expressed in the albino A. japonicus. The gene ontology analysis indicated that the transcription of genes associated with the terms of biological regulation and pigmenta-tion was non-abundant in the albino library compared to the control. Based on an analysis using the Kyoto Encyclopedia of Genes and Genomics (KEGG) database, we identified 14 important genes that were in-volved in major intercellular signaling pathways related to melanin synthesis, such as tyrosine metabolism, the mitogen-activated protein kinase (MAPK) pathway, and melanogenesis. The expressions of fibroblast growth factor receptor 4 (FGFR4), protein kinase C (PKC), protein kinase A (PKA), and Ras genes were sig-nificantly down-regulated in the albino transcriptome compared with the control, while the expressions of homogentisate 1, 2-dioxygenase gene (HGO), cAMP-responsive element binding protein (CREB), transcrip-tion factor AP-1(c-jun), and calmodulin (CaM) were significantly up-regulated (Fisher's exact test,p < 0.05). These differentially expressed genes could be candidate genes for revealing the mechanism of albinism and investigating regulation of melanin synthesis inA. japonicus.

  7. Hematological and Histological Response of Wister Albino Rat Rattus norvegicus a Dietary Supplement of Seaweed Diet Gracilaria edulis

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    T. Anbalagan

    2009-10-01

    Full Text Available A dietary supplementation of seaweed Gracilaria edulis haematological and histological responseof albino rat Rattus norvegicus .The blood protein, cholesterol, albumin, calcium, phosphorus and urea of theseaweed feed albino rats having an increased tendency during the experimentation when compared with controlrats. Its note mostly that the experimental rat showing a decreasing level of glucose when compared withcontrol rats. The oral picture of the haematological change of albino rat fed with seaweed diet evidenced theiractive participation on the metabolism of the experimental subject. These findings w ere well correlated w ithhistological observation in the liver and intestine shows the hepatocyte appearance and deposited fat and fociat necrosis is also seen in photomicrographs.

  8. Studies on the hypolipidemic effects of Coconut oil when blended with Tiger nut oil and fed to albino rats

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    El-Anany, A. M.

    2012-09-01

    Full Text Available Hyperlipidemia is a predominant risk factor for atherosclerosis and associated cardiovascular diseases (CVD. The international guidelines issued by the World Health Organization recommend a reduction in dietary saturated fat and cholesterol intake as a means to prevent hypercholesterolemia and CVD. The main objective of the current investigation was to evaluate the effects of feeding blended oils consisting of coconut oil (CNO with different proportions of Tiger nut oil (TNO on serum lipid levels in Albino rats. GLC analysis was performed to illustrate the fatty acid composition of the blended oils. Blended oils were obtained by mixing tiger nut oil with coconut oil at the volume ratios of 100:0, 70:30, 50:50, 25:75, 10:90 and 0:100. Fifty-six male albino rats were randomly divided into 7 groups of 8 rats each according to the oil type. The blended oils were fed to rats for a period of up to 10 weeks. Total cholesterol (T-Ch, high-density lipoprotein cholesterol (HDL-Ch, low-density lipoprotein cholesterol (LDL-Ch, and triglycerides (TG, were determined. The atherogenic Index (AI was calculated. The results showed that non-significant changes in all nutritional parameters were observed between the control group and the rats fed with the tested oils. The results also indicate that coconut oil had 86% saturated fatty acids. On TNO contains 66% oleic acid. Therefore, blending coconut oil with tiger nut oil can reduce the proportions of saturated to unsaturated fatty acids in CNO. The rats that were fed blended oils showed significantly reduced levels of serum cholesterol as compared to those fed CNO. The HDL levels were marginally enhanced in the rats that were fed blended oils. The total cholesterol and LDL cholesterol levels were controlled when TNO/CNO proportions varied between 25/75 and 70/30. This was reflected in the calculation of the atherogenic index. Similar changes were observed with serum triglyceride levels.

    La hiperlipidemia

  9. Logros en educacion secundaria y su relacion con inteligencia y con resolucion de problemas nuevos

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    Nuria Cortada de Kohan

    1998-01-01

    Full Text Available En esta investigación, que es una segunda parte de la ya presentada en esta Revista Latinoamericana de Psicología. Vol. 29, N° 1, 1997, hemos tratado de profundizar en la relación entre procesos de pensamiento, inteligencia general y logros en educación. Hemos utilizado un proyecto metodológicamente similar al usado con los alumnos primarios elaborando tests de conocimientoadhoc para alumnos del último año de la Escuela Secundaria. Asimismo hemos aplicado a la misma muestra de 200 alumnos aproximadamente el Test de las Matrices Progresivas de Raven, Forma Avanzada, y hemos utilizado 5 problemas para analizar las estrategias de pensamiento de los creados por Rimoldi para resolución de problemas nuevos. Los resultados, de manera similar con Jo que ocurrió en la muestra de alumnos primarios, nos permite concluir que decididamente la escuela no parece aprovechar debidamente los recursos intelectuales de los jóvenes. y esto avala las ideas de muchos pensadores actuales que consideran que los sistemas usuales de enseñanza deben ser drásticamente modificados.

  10. MORFOLOGIA DO TIMO DE COELHOS NOVA ZELÂNDIA BRANCO TRATADOS COM GENTAMICINA

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    Matheus Henrique Magalhães Silva

    2013-06-01

    Full Text Available Considering the thymus importance for the immune system and the immunodepressive potential of gentamicin, this study aimed to evaluate the effects of this aminoglycoside on the thymus histology of New Zealand White rabbits. For this, it were used 20 adult rabbits, 10 males and 10 females with a mean weight of 2.5 kg, healthy, of the New Zealand White breed, which were divided into two groups (control and treated, with five males and five females each. After seven days of daily treatment with 4.4 mg/kg of gentamicin by subcutaneous injection, on the eighth day the animals were sacrificed and their thymuses, after collected, were fixed in Bouin solution for 24 hours and processed routinely for embedded in paraffin. After the semi-serial microtome with thickness of 5 µm at intervals of 1000 µm, the histological sections were stained using Masson’s Trichrome techniques. It were analyzed, by light microscopy, the morphological characteristics of cortical and medullary of thymic individualized lobes of these sections. It was not observed histological differences between sexes or between control and treated groups. The results showed that this antibiotic, used in therapeutic dosage and by the recommended period, did not alter the morphology of the thymus of treated animals.Considerando-se a importância do timo para o sistema imunológico e o potencial imunodepressor da gentamicina, este estudo objetivou avaliar os efeitos deste aminoglicosídeo sobre a histologia do timo de coelhos da raça Nova Zelândia Branco. Para isto, utilizou-se 20 coelhos adultos, 10 machos e 10 fêmeas, com peso médio de 2,5 kg, hígidos, da raça Nova Zelândia Branco, os quais foram divididos em dois grupos (controle e tratado com cinco machos e cinco fêmeas cada. Após sete dias de tratamento diário com 4,4 mg/kg de gentamicina por via subcutânea, no oitavo dia, os animais foram sacrificados e seus timos, após coletados, foram fixados em solução de Bouin por 24

  11. Um albino parcial de veado campeiro (Ozotoceros bezoarticus, Linnaeus no Parque Nacional das Emas, Goiás Partial albinism in the pampas deer and a critical analysis about albino Mammals

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    Flávio H.G. Rodrigues

    1999-01-01

    Full Text Available A case of partial albinism in the pampas deer, recorded at the Emas National Park, Goiás, Brazil is described. The coat color and behaviour of the albino are compared with normal pampas deer.

  12. Sífilis secundaria en un paciente viviendo con VIH

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    Mauricio La Rosa

    2007-07-01

    Full Text Available Se presenta el caso de un paciente varón de 31 años, con diagnóstico de infección por el virus de inmunodeficiencia humana (VIH sin tratamiento antirretroviral, presentó lesiones ulcerativas en la región genital que luego progresaron por todo el cuerpo, se le diagnosticó sífilis secundaria. Fue tratado con penicilina benzatínica, con lo cual las lesiones desaparecieron. Se discute las pruebas diagnósticas realizadas y la terapéutica empleada. La coinfección por Treponema pallidum y por el VIH está presente en la población general y en especial en poblaciones de riesgo, como los hombres que tienen sexo con hombres y clientes de trabajadoras sexuales, esta situación puede afectar la presentación inicial así como el curso de la enfermedad.

  13. Prevalencia, factores de riesgo y características patogénicas diferenciales de EPOC y enfisema en pacientes con infección VIH

    OpenAIRE

    Sampériz Abad, Gloria; Riera Jaume, Melcior; Marín Trigo, José María

    2014-01-01

    Antecedentes: Las anomalías pulmonares están a menudo presentes en pacientes infectados con el virus de la inmunodeficiencia humana (VIH). Objetivos: Determinar la prevalencia, las características patogénicas y los factores de riesgo de anormalidades pulmonares en pacientes VIH +. Métodos: Se incluyeron en el estudio 275 pacientes VIH +, con una media (± desviación estandar) de edad de 48,5 (± 6,6) años y en su mayoría (95,6%) tratados con terapia antirretroviral de gran actividad (TARGA), Se...

  14. Transportación ósea en defectos masivos de la tibia con fijador externo RALCA

    OpenAIRE

    Mario Milanés Castellanos; Juan Vicente Quezada Musa; Eraclio Delgado Rifá

    2014-01-01

    Se presenta un paciente masculino, de 20 años de edad, que sufrió una fractura expuesta de la tibia derecha, grado II, el cual fue tratado, según el protocolo de urgencia, con la aplicación de antibióticos, desbridamiento, colocación de osteosíntesis interna mediante una placa de compresión y cobertura cutánea de la fractura. Se comenzó a observar una evolución desfavorable, con enrojecimiento de la piel y sepsis local mantenida, a pesar de desbridamientos repetidos y antibioticoterapia, lo ...

  15. La osteosíntesis con placa volar como tratamiento de las fracturas complejas del radio distal

    OpenAIRE

    Arenas Planelles, Antonio; Ortega Arruti, J.A.; Corchuelo Maíllo, C.; Arenas Miquélez, A.; Ortega Sáez, M. (Marta)

    2006-01-01

    Se presentan 45 casos de fractura compleja del radio distal tratados mediante reducción abierta y osteosíntesis con placa palmar. Los resultados fueron satisfactorios en 42 casos (93,3 %), con pocas complicaciones durante su evolución 45 cases of complex fracture of the distal radius are presented. They were treated by open reduction and stable fixation with a volar plate. The results were satisfactory in 42 cases (93,3 %), with few complications during their evolution.

  16. Tratamiento de alteraciones funcionales y dentomaxilofaciales con el método de Fränkel

    OpenAIRE

    Romero Zaldivar, Esperanza C.

    1997-01-01

    Se realizó un estudio descriptivo en 22 pacientes tratados con los reguladores de función de Fränkel para determinar los resultados de tratamiento mediante este método, los que se seleccionaron de acuerdo con la clasificación de síndromes planteada por Moyers y que presentaban dentición mixta, en las edades comprendidas de siete a nueve años. El grupo original estuvo constituido por 55 pacientes que ingresaron en el servicio de Ortodoncia de la Clínica Estomatológica Docente La Vigía desde j...

  17. Glosectomía parcial reconstruida con colgajo libre del radial. Propuesta de tratamiento fisioterápico

    OpenAIRE

    Almeida Santamaría, Mercedes

    2013-01-01

    El carcinoma escamoso de la lengua en estadio avanzado que es tratado quirúrgicamente con glosectomía reconstruida con colgajo libre del radial, resección de ganglios linfáticos afectados y radioterapia va a ocasionar secuelas en diferentes áreas corporales: lengua, columna cervical y miembro superior, afectándose el recorrido articular, la fuerza muscular, la sensibilidad táctil, la flexibilidad de los tejidos blandos y el drenaje linfático. El planteamiento de un tratamiento fisioterápico b...

  18. Improvement of sperm density in neem-oil induced infertile male albino rats by Ipomoea digitata Linn

    OpenAIRE

    Ghanashyam Keshav Mahajan; Raghunath Totaram Mahajan; Mahajan, Arun Y.

    2015-01-01

    Aim: Investigation has been carried out to validate folkloric claim of the potential of ID based on reproductive health status in experimentally induced male albino rats. Materials and Methods: Emulsified neem oil (ENO) fed albino rats were orally administered root powder of ID suspended in water for the doses of 250 and 500 mg/kg body weight for 40 days. Change in organ weight, sperm density and motility, serum hormonal levels and histomorphological changes were evaluated. Results: Significa...

  19. Lead acetate toxicity on glucose level and liver enzymes ameliorated by camel's milk in wistar albino rat

    OpenAIRE

    Draid, Marwan M.; Mujahed O. Bushwereb; Shadia G. Ramadan

    2016-01-01

    Background: The present work was conducted to investigate the effects of lead acetate intoxication on glucose and liver functions in albino rats, and the possible effectiveness of using camel milk to protect against lead induced toxicity. Methods: Eighteen male albino rats were divided into three groups of six, the first was a control group, the second received orally lead acetate in water as (2 ml saline containing 5 mg/kg body weight of lead acetate) and the third received the same ...

  20. El individuo ante la biopolítica: Tratado de Libre Comercio Colombia-EE.UU.

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    Martha Isabel G\\u00F3mez Lee

    2009-01-01

    Full Text Available El problema de las patentes de biotecnología puede ser visto como un asunto de política de ciencia y tecnología, en la que el contexto de la globalización y de la sociedad del conocimiento cruza la política de la vida o biopolítica. En los Estados Unidos se considera un asunto de política pública del conocimiento, mientras que en Colombia es una cuestión de política social y ambiental. Los ciudadanos colombianos tienen mucho que decir y controlar en la revolución biotecnológica y comercial que redimensiona la extracción de renta de la tierra y reconfi gura a la biodiversidad colombiana como nueva renta de germoplasma global. Los individuos están llamados a actuar de manera creativa en tres dimensiones: como agentes políticos y fuente de razones y acciones políticas, como objetivo último de las decisiones y las acciones de la biopolítica y como interfase entre las políticas públicas globales y las sociales. En esta última dimensión, el individuo colombiano es un actor político fundamental en las negociaciones del Tratado de Libre Comercio entre Estados Unidos y Colombia por ser él un actor activo de la sociedad civil en defensa de la vida.

  1. El individuo ante la biopolítica: Tratado de Libre Comercio Colombia-EE.UU.

    Directory of Open Access Journals (Sweden)

    Martha Isabel Gómez Lee

    2009-11-01

    Full Text Available El problema de las patentes de biotecnología puede ser visto como un asunto de política de ciencia y tecnología, en la que el contexto de la globalización y de la sociedad del conocimiento cruza la política de la vida o biopolítica. En los Estados Unidos se considera un asunto de política pública del conocimiento, mientras que en Colombia es una cuestión de política social y ambiental. Los ciudadanos colombianos tienen mucho que decir y controlar en la revolución biotecnológica y comercial que redimensiona la extracción de renta de la tierra y reconfigura a la biodiversidad colombiana como nueva renta de germoplasma global. Los individuos están llamados a actuar de manera creativa en tres dimensiones: como agentes políticos y fuente de razones y acciones políticas, como objetivo último de las decisiones y las acciones de la biopolítica y como interfase entre las políticas públicas globales y las sociales. En esta última dimensión, el individuo colombiano es un actor político fundamental en las negociaciones del Tratado de Libre Comercio entre Estados Unidos y Colombia por ser él un actor activo de la sociedad civil en defensa de la vida.

  2. Las aspiraciones cosmpolitas de la ciudadanía europea a la luz del Tratado de Lisboa

    OpenAIRE

    Jose Antonio García Saez

    2010-01-01

     En octubre de 2009 se repetirá el referéndum irlandés sobre el Tratado de Lisboa. El accidentado proceso de gestación de este tratado, heredero a su vez de la non nata Constitución Europea, suscita algunas dudas en torno a la concepción de ciudadanía europea que vienen manejando las instituciones de la UE. En el presente artículo se intentará aportar algunos elementos de reflexión sobre esta concepción de ciudadanía tomando como referencia el ideal más amplio de la ciudadanía cosmopolita. Pa...

  3. EXPERIMENTANDO CON SUJETOS EMOCIONADOS

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    Mercedes Rivero Obra

    2013-12-01

    Full Text Available Este artículo trata de investigar si es posible que se produzca una emoción partiendo solo de su expresión, y no de un estímulo. Para ello se analizarán algunos trabajos de autores como William James, Francisco Alcayde y Vilar o la psicóloga chilena Susana Bloch. Todos ellos han tratado de demostrar que la expresión de una emoción puede conducir al sujeto a experimentarla. Sin embargo, estas tesis cometen el error de abolir el pensamiento del sujeto, otorgándole una especial importancia a la parte física que diferencian de la que podríamos llamar la parte mental.

  4. [Obtaining and analysis of intergeneric somatic hybrids between Brassica napus and "albino" line of Orychophragmus violaceus].

    Science.gov (United States)

    Vasilenko, M Iu; Komarnitskiĭ, I K; Sakhno, L A; Gleba, Iu Iu; Kuchuk, N V

    2003-01-01

    The Orychophragmus violaceus chlorophylldefective line of "albino" type has been obtained by spectinomycin treatment. Somatic hybridization between Orychophragmus violaceus and Brassica napus was performed by fusion of green mesophyll protoplasts of rape and callus protoplasts of the O. violaceus "albino" line. Near two hundred of regenerant plants were selected according to the regeneration type and ability to become green, and were determined as hybrids. Chloroplast DNA in selected hybrids was identical to rape chlDNA, which was confirmed by the PCR-RFLP analysis of plastid DNA fragments. Fragments of hybrid mitochondrial DNA analyzed by the PCR-RFLP analysis were identical to fragments of O. violaceus. The nuclear genome of the majority of hybrids was represented by the O. violaceus genome, which was demonstrated by analyses of isoenzymes, DNA telomeric sequences, ribosomal and satellite DNAs, and the RAPD analysis. The cytogenetic analysis of a number of lines has shown variability in the number of chromosomes in the obtained lines. PMID:12741055

  5. EFFECTS OF POTASSIUM BROMATE ON THE KIDNEY AND HAEMATOLOGICAL PARAMETERS OF SWISS ALBINO MICE

    Directory of Open Access Journals (Sweden)

    MARIA STUTI

    2013-01-01

    Full Text Available The present study aimed to investigate the possible effects of potassium bromate toxicity on histological,haematological and biochemical parameters in Swiss albino mice. Mice were orally administered with potassiumbromate at the rate of 150 mg/kg body weight daily in a single dose for 30, 60 and 120 days. The chemicalsignificantly reduced the RBC count (p<0.01 Hb% (p<0.01 and platelet count (p<0.01, while it increasedsignificantly the urea (p<0.01 and creatinine level (p<0.01 and decreased total protein and Albumin (p<0.01Histopathological examination showed degenerative changes of tubular cells, cytoplasma vacuolation, cellularinfiltration, tubular dilation with eosinophilic debris and clear cell cytoplasm were observed. These findingssuggest that KBrO3 affects the physiological and biochemical activities of Swiss albino mice

  6. ¿Es necesaria la reconstrucción de la conjuntiva?: Trabajo experimental en conejos albinos para evaluar la neogénesis de la conjuntiva

    Directory of Open Access Journals (Sweden)

    E. A. Moretti

    2007-03-01

    Full Text Available En los defectos de espesor total del párpado inferior de gran magnitud, siempre ha sido regla de oro la reconstrucción de la lamela posterior (tarso y conjuntiva palpebral. Esto es debido a que el tono del músculo orbicularis oculi no alcanza a mantener el soporte necesario para resistir la acción de la gravedad y/o contractura cicatricial. Además la ausencia de conjuntiva provocaría lesiones sobre la córnea ocular. Es por ello que el empleo de injertos compuestos condromucosos ha sido insustituible. El presente trabajo de investigación fue realizado en 20 conejos albinos con el objeto de evaluar la posibilidad de emplear cartílago auricular para la reconstrucción del tarso sin colocación de mucosa a modo de conjuntiva sobre dicho cartílago. Los resultados obtenidos permiten confirmar por diferentes tinciones histológicas sobre biopsias comparadas con zonas testigo, el crecimiento de tejido conjuntival sobre el pericondrio sin provocar lesiones oculares (neogénesis de conjuntiva. Los hallazgos encontrados provocan importantes y sustanciales cambios en la cirugía reconstructiva del párpado inferior debido a que de esta manera, no sería necesaria la reconstrucción de la conjuntiva palpebral, siendo útil exclusivamente la colocación de cartílago.

  7. Legitimidad y finalidad de los capítulos de propiedad intelectual en los tratados de libre comercio (TLC

    Directory of Open Access Journals (Sweden)

    Susy Frankel

    2011-11-01

    Full Text Available Una visión analítica de la realidad actual permite apreciar un auge de los Tratados de Libre Comercio, mientras se presenta un estancamiento en las negociaciones multilaterales de comercio. Si bien la negociación de los TLC no se limita a los países desarrollados, los negociados por los países en desarrollo no tienden a contemplar mejoras en los estándares de propiedad intelectual. Algunos de los capítulos relativos a la propiedad intelectual incluidos en los Tratados de Libre Comercio simplemente reafirman los estándares del acuerdo sobre los ADPIC, mientras que otros se orientan a ampliar el cubrimiento y alcance de los derechos internacionales de propiedad intelectual. El presente artículo se concentra en estudiar la legitimidad y la finalidad de los capítulos de propiedad intelectual en los Tratados de Libre Comercio, así como la relación entre los capítulos sobre propiedad intelectual y el sistema multilateral de la Organización Mundial del Comercio (OMC que facilita los TLC y los límites racionales de la propiedad intelectual en el contexto comercial.

  8. Antiovulatory and estrogenic activity of Plumbago rosea leaves in female albino rats

    OpenAIRE

    Sheeja E; Joshi S; Jain D

    2009-01-01

    Objective : To evaluate the effect of petroleum ether (60-80), chloroform, acetone, ethanol and aqueous extracts of Plumbago rosea leaves on the estrous cycle and to identify the estrogenic activity of active acetone and ethanol extracts in female albino rats. Methods : Plant extracts were tested for their effect on the estrous cycle at two dose levels: 200 and 400 mg/kg, respectively. The effective acetone and ethanol extracts were further studied on estrogenic activity in rats. Histologica...

  9. Antiovulatory and estrogenic activity of Plumbago rosea leaves in female albino rats

    OpenAIRE

    Sheeja, E.; Joshi, S.B.; D. C. Jain

    2009-01-01

    Objective: To evaluate the effect of petroleum ether (60–80°), chloroform, acetone, ethanol and aqueous extracts of Plumbago rosea leaves on the estrous cycle and to identify the estrogenic activity of active acetone and ethanol extracts in female albino rats. Methods: Plant extracts were tested for their effect on the estrous cycle at two dose levels: 200 and 400 mg/kg, respectively. The effective acetone and ethanol extracts were further studied on estrogenic activity in rats. Histological ...

  10. Effect of nigella sativa seeds extract on serum c-reactive protein in albino rats

    International Nuclear Information System (INIS)

    C-reactive protein (CRP) is an acute phase protein. It predicts future risk of cardiovascular diseases. Different medicinal plants and their active ingredients possess the ability to reduce serum CRP levels and hence inflammatory disorders and cardiovascular diseases. In our study, ethanolic extract of Nigella sativa seeds was evaluated in albino rats for its possible effect on serum CRP levels. Objective: The objective of this study was to determine the effect of ethanolic extract of Nigella sativa seeds on an acute inflammatory biomarker/mediator, C-reactive protein (CRP) in albino rats. Study Design: Randomized controlled trial (RCT). Place and Duration of Study: Physiology Department, Services Institute of Medical Sciences (SIMS), Lahore; from September to November, 2009. Subjects and Methods: The study was carried out on 90 male albino rats. Five percent (5%) formalin in a dose of 50 meu1 was injected into sub-plantar surface of right hind paw of each rat to produce inflammation. The rats were randomly divided into three groups of thirty each. Group A was given normal saline (control); group B was given Nigella sativa seed extract; and group C received diclofenac sodium, as a reference drug. CRP levels in each group were measured from blood samples taken 25 hours after giving formalin. Results: The ethanolic extract of Nigella sativa seeds, given intraperitoneally, caused highly significant (p<0.001) reduction in serum CRP levels as compared to control group. The reduction in CRP levels by ethanolic extract of Nigella sativa was also significantly (p<0.05) more than that produced by diclofenac sodium. Conclusion: Our results suggest that Nigella sativa possesses ability to reduce serum CRP levels significantly, after production of artificial inflammation, in albino rats. (author)

  11. Evaluation of the aphrodisiac activity of Tribulus terrestris Linn. in sexually sluggish male albino rats

    OpenAIRE

    Surender Singh; Vinod Nair; Yogendra K Gupta

    2012-01-01

    Objectives: To study the effect of acute and repeated dose administration of lyophilized aqueous extract of the dried fruits of Tribulus terrestris (LAET) on sexual function in sexually sluggish male albino rats. Materials and Methods: Aphrodisiac activity of the test drug was evaluated in terms of exhibited sexual behavior. In order to assess the effect of chronic T. terrestris exposure on the hypothalamus--pituitary--gonadal axis, testosterone level estimation and sperm count were carried o...

  12. Effect of Feeding Chapaties Preserved with Sorbic Acid on Growth and Reproduction of Albino Rats

    Directory of Open Access Journals (Sweden)

    T.S. Satyanarayana Rao

    1974-04-01

    Full Text Available Sorbic acid, used in concentration of o.3% in chapaties and found satisfactory as a preservative, has been investigated for its safety of use by long term feeding studies with albino rats. The data obtained with regard to growth rate, food consumption, organ to body weight ratio and performance in reproduction show that the preserved foodstuffs containing sorbic acid in the concentration of o.3% are safe for consumption.

  13. PRELIMINARY PHYTOCHEMICAL ANALYSIS AND ACUTE ORAL TOXICITY STUDY OF MUCUNA PRURIENS LINN. IN ALBINO MICE

    OpenAIRE

    Deka Manalisha; Kalita Jogen Chandra

    2012-01-01

    Mucuna Pruriens Linn. is an annual, climbing shrub which has an important place among aphrodisiac herbs in India since the ancient times. The plant has been using traditionally for many medicinal purposes such as Infertility, Parkinson’s disease, Loss of libido, Antioxidant, Anti venom, Anti microbial etc. The present study was carried out to investigate the preliminary phytochemical analysis and acute oral toxicity of the seeds of M.pruriens on albino mice. Matured seeds of M.pruriens were d...

  14. Protective Effect of Rosemary (Rosmarinus Officinalis) Extract on Naphthalene Induced Nephrotoxicity in Adult Male Albino Rat

    OpenAIRE

    Neveen M. El-Sherif; Noha Mohy Issa

    2015-01-01

    Background: Naphthalene (NA) is a common environmental contaminant and is abundant in tobacco smoke. Rosemary (Rosmarinus officinalis) is a herb commonly used as a spice and flavoring agents in food processing and is useful in the treatment of many diseases. Aim of the work: To study the nephrotoxicity of NA and to evaluate the possible protective role of rosemary extract in adult male albino rat. Materials and Methods: 25 animals were divided into three groups: Group I (Control group), G...

  15. Histopathological effects of pesticide-cholopyrifos on kidney in albino rats

    OpenAIRE

    Rekha; Sunanda Raina; Sajad Hamid

    2013-01-01

    Background: Histopathological lesions have been widely used as biomarkers for health evaluation of organism exposed to pollutants and can be used as warning symptoms for organism health. There are few reports regarding histomorphological changes in kidney following pesticide chlorpyrifos exposure which has prompted us to undertake this study. Methods: The present study was conducted on 45 inbred adult Wistar albino rats of either sex, weighing 145 – 165 gms. These animals were randomly d...

  16. The genome sequencing of an albino Western lowland gorilla reveals inbreeding in the wild

    OpenAIRE

    Prado-Martinez, Javier; Hernando-Herraez, Irene; Lorente-Galdos, Belen; Dabad, Marc; Ramirez, Oscar; Baeza-Delgado, Carlos; Morcillo-Suarez, Carlos; Alkan, Can; Hormozdiari, Fereydoun; Raineri, Emanuele; Estellé, Jordi; Fernandez-Callejo, Marcos; Valles, Mònica; Ritscher, Lars; Schöneberg, Torsten

    2013-01-01

    Background The only known albino gorilla, named Snowflake, was a male wild born individual from Equatorial Guinea who lived at the Barcelona Zoo for almost 40 years. He was diagnosed with non-syndromic oculocutaneous albinism, i.e. white hair, light eyes, pink skin, photophobia and reduced visual acuity. Despite previous efforts to explain the genetic cause, this is still unknown. Here, we study the genetic cause of his albinism and making use of whole genome sequencing data we find a higher ...

  17. Comparative Study of Wound Healing Activity of Topical and Oral Ocimum Sanctum Linn in Albino Rats

    OpenAIRE

    Asha, B.; Nagabhushan, A.; G. H. Shashikala

    2011-01-01

    Introduction: Ocimum sanctum, when given orally in one of the studies showed wound healing property. Since majority of the agents tried for wound healing are topical, the present study was planned to compare the oral and topical Ocimum sanctum for wound healing property. Methods: Excision and incision resutured wound models in albino rats were used to study complete epithelisation time, wound contraction, histopathological study and tensile strength of the wounds. Results: The animals were di...

  18. EFFECT OF AMLODIPINE ON ORAL GLUCOSE INDUCED GLYCEMIC CHANGES IN NORMAL ALBINO RATS

    OpenAIRE

    Dr. Sushma V. Naidu et al

    2012-01-01

    Objective: To determine the effect of amlodipine on blood glucose levels through oral glucose tolerance test in normoglycemic albino Rats and the magnitude of its effect on basal v/s glucose induced glycemic value compared to control.Methods: Rats were divided into control and test groups to study the effect of glucose induced glycemic changes in normal rats following oral administration of amlodipine. The control group received 1 ml of distilled water everyday, test group received amlo...

  19. Effect of Aqueous Flower Extract of Catharanthus roseus on Alloxan Induced Diabetes in Male Albino Rats

    OpenAIRE

    Natarajan, A.; K. Syed Zameer Ahmed; Sundaresan, S.; A. Sivaraj; Devi, K; B Senthil Kumar

    2012-01-01

    Catharanthus roseus is widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus. The present study was carried out to investigate the antidiabetic and hyperlipidemic potential of Catharanthus roseus on alloxan induced diabetes in male albino rats. Oral administration of aqueous extract of Catharanthus roseus at a dose of 250 mg, 350 mg, and 450 mg/kg body weight for 30 days to diabetic rats resulted in significant reduction in blood glucose, reduction in lipid profile a...

  20. HEPATOPROTECTIVE ROLE OF SODIUM SELENITE AGAINST OXIDATIVE DAMAGE INDUCED BY MERCURIC CHLORIDE IN RAT ALBINOS WISTAR

    OpenAIRE

    Youcef Necib; Ahlem Bahi; Sakina Zerizer; Cherif Abdennour; Mohamed Salah Boulakoud

    2013-01-01

    Background: The present study was undertaken, to evaluate the protective effect of sodium selenite against mercuric chloride induced oxidative stress in experimental rats. Female Albinos Wistar rats randomly divided into four groups, were the first was served as a control, whereas the remaining groups respectively treated with: sodium selenite (1mg/ kg b.w; ip), mercuric chloride (1 mg/kg body weight i.p) and combination of sodium selenite and HgCl2. Change in liver enzyme activities, thiobar...

  1. Physiological Changes Induced by Long Term Administration of Saccharin Compared with Aspartame to Male Albino Rats

    OpenAIRE

    Abdallah, Inas Z. A.

    2002-01-01

    Artificial sweeteners have been in use by food industries for a long time. Safety concerns raised about artificial sweeteners since they are widely used nowadays. The present work aims to study the possible changes in body weight, blood picture, liver functions, blood glucose and liver glycogen content as wel as histopathological changes induced in liver and urinary bladder of male albino rats after administration of two artificial sweeteners (saccharin or aspartame). Male rats were administe...

  2. Tratamiento de las fracturas del húmero proximal con placas bloqueadas

    OpenAIRE

    Arenas Planelles, Antonio; D'Arrigo, A.; Arenas Miquélez, A.; Jiménez Sarmiento, O.

    2011-01-01

    Se presentan 86 casos de fractura compleja de húmero proximal tratados mediante reducción abierta y osteosíntesis con placa bloqueada. Los resultados fueron buenos en la mayor parte de los pacientes. Los autores analizan los factores que han influido en los resultados del tratamiento 86 cases of complex fracture of the proximal humerus are presented. They were treated by open reduction and internal fixation with a locking plate. The results were satisfactory at most of the patient...

  3. Actividades enriquecidas con el uso de vídeos en aulas hospitalarias

    OpenAIRE

    Serrano Sánchez, José Luis; López Moya, Mª Del Pilar

    2014-01-01

    En los últimos años han proliferado buenas prácticas en el uso de Tecnologías de la Información y la Comunicación en contextos educativos hospitalarias, y en ocasiones se han llevado a cabo investigaciones que han tratado de analizar las posibilidades de las tecnologías en estos espacios educativos. Partiendo de estas experiencias, presentamos una innovación educativa con el uso del vídeo como tecnología enriquecedora de los procesos educativos en las aulas hospitalarias de ...

  4. GCompris: un software multinivelar con clara aplicación para las matemáticas

    OpenAIRE

    Real, Mariano

    2011-01-01

    En esta sección MatemásTIC de la revista Suma hemos estado analizando y haciendo un recorrido por aplicaciones de software libre o bien con licencia GPL de forma que el uso de estas aplicaciones no tenga un coste económico y se puedan disponer de las mismas en la red o bien a través de los repositorios de las diferentes distribuciones Linux. En ese recorrido que aún seguimos, hemos tratado aplicaciones recomendadas para el aula de matemáticas haciendo especial hincapié en aplicaciones indicad...

  5. Evaluation of hepatoprotective activity of aqueous extracts of leaves of Basella alba in albino rats.

    Science.gov (United States)

    Das, Saibal; Bandyopadhyay, Sanjib; Ramasamy, Anand; Mondal, Somnath

    2015-01-01

    This study was done to evaluate possible hepatoprotective effects of aqueous leaf extracts of Basella alba in comparison with silymarin in paracetamol-induced hepatotoxicity in albino rats. Six groups of six albino rats each received orally for 6 weeks, vehicle, paracetamol (2 g/kg/day), paracetamol (2 g/kg/day) plus silymarin (50 mg/kg/day), paracetamol (2 g/kg/day) plus B. alba extract (60 mg/kg/day), paracetamol (2 g/kg/day) plus B. alba extract (80 mg/kg/day) and paracetamol (2 g/kg/day) plus B. alba extract (100 mg/kg/day). Hepatoprotective effect was evaluated by comparing serum bilirubin, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, proteins, alkaline phosphatase and liver histopathology. Results were represented as mean ± SEM. One-way ANOVA was done followed by post hoc Tukey's test with a highly significance level of P alba 100 mg/kg/day orally had significant hepatoprotective effect in paracetamol-induced hepatotoxicity in albino rats. The results were well comparable and even in some respects superior to standard drug silymarin. PMID:25347929

  6. Bioprotection of Spruce Logs Against Sapstain Using an Albino Strain of Ceratocystis resinifera.

    Science.gov (United States)

    Morin, Chantal; Tanguay, Philippe; Breuil, Colette; Yang, Dian-Qing; Bernier, Louis

    2006-05-01

    ABSTRACT We recovered a spontaneous albino strain from ascospores of Ceratocystis resinifera, a sapstain fungus that grows deeply and rapidly in freshly felled conifer trees. This albino strain, named Kasper, was tested for its ability to prevent discoloration of spruce sapwood caused by wild-type sapstain fungi and compared with Cartapip 97, a commercially available biological control agent of sapstain in lodgepole pine and red pine logs. In a laboratory trial, Kasper reduced sapstain of white spruce logs as much as 94.4% and was more efficient than Cartapip 97. In field trials conducted in an area north of Québec City, Kasper reduced sapstain of black spruce as much as 80%. In three of four field trials, Kasper was significantly more efficient than Cartapip 97 in reducing sapstain development. The exception was encountered in a 2003 trial conducted in a sawmill yard where Kasper did not reduce sapstain. In a field trial conducted in western Canada, at Aleza Lake forest near Prince George, Kasper almost totally prevented the development of sapstain, even after 24 weeks. These results suggest albino strains derived from C. resinifera might be an additional source of potential biocontrol agents against sapstain.

  7. Histological review of skin cancers in African Albinos: a 10-year retrospective review

    International Nuclear Information System (INIS)

    Skin cancer is rare among Africans and albinism is an established risk for skin cancer in this population. Ultraviolet radiation is highest at the equator and African albinos living close to the equator have the highest risk of developing skin cancers. This was a retrospective study that involved histological review of all specimens with skin cancers from African albinos submitted to The Regional Dermatology Training Center in Moshi, Tanzania from 2002 to 2011. A total of 134 biopsies from 86 patients with a male to female ratio of 1:1 were reviewed. Head and neck was the commonest (n = 75, 56.0%) site affected by skin cancers. Squamous cell carcinoma (SCC) was more common than basal cell carcinoma (BCC) with a ratio of 1.2:1. Only one Acral lentiginous melanoma was reported. Majority (55.6%) of SCC were well differentiated while nodular BCC (75%) was the most common type of BCC. Squamous cell carcinoma is more common than basal cell carcinoma in African albinos

  8. Citrus aurantifolia impairs fertility facilitators and indices in male albino wistar rats

    Directory of Open Access Journals (Sweden)

    Uduak Akpan Okon

    2014-06-01

    Full Text Available Background: The ability to reproduce is one of lifes essential functions; therefore factors that affect this ability are of vital importance to mankind. We therefore designed this study to assess the effect of various dosages of C. aurantifolia treatment on fertility promoters and indices in male albino wistar rats. Methods: Toxicity studies showed no lethality at 5000 mg/kg. Eighteen male albino wistar rats weighing between 220 and 240 g were used. They were randomly assigned into three groups of six rats each. Group one served as control and was gavaged 5 ml of normal saline, groups two and three were gavaged 1000 mg/kg and 1500 mg/kg body weight as medium and high dose respectively twice daily for 21 days. On the 22nd day, the rats were sacrificed and blood samples were obtained by cardiac puncture; following standard procedure, the serum was obtained for hormonal (FSH, LH, prolactin and testosterone assay using microplate immunoenzymometric assay. The testes were harvested for semen analysis. Results: LH level was significantly lower in medium dose (P Citrus aurantifolia possess antifertility potentials in male albino wistar rats. Excessive intake should be with caution in males with fertility challenges. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 640-645

  9. Cuidados con el anciano con tos productiva.

    OpenAIRE

    Costa de Moura, María Lucia

    2005-01-01

    A partir de las informaciones y con la motivación para hacer un estudio dirigido a los cuidados con el anciano, sigue la necesidad del desarrollo de acciones pertinentes para la práctica de cuidar, o sea, la asistencia de enfermería prestada directamente al anciano, principalmente a aquellos que llegan a la unidad de salud quejándose de tos. El objeto de este estudio es la asistencia de enfermería basándome en las cuestiones que rodean la percepción del enfermero y cómo el...

  10. Los servicios profesionales en América del Norte. Un análisis de sus resultados y perspectivas a partir del Tratado de Libre Comercio

    Directory of Open Access Journals (Sweden)

    María Yira Figueroa Olvera

    2008-01-01

    Full Text Available Este trabajo presenta las características actuales del mercado laboral en América del Norte, para ello se toma como marco de referencia el Tratado de Libre Comercio de América del Norte (TLCAN. Asimismo, se analizan los resultados actuales y las perspectivas futuras de la prestación de servicios profesionales entre Canadá, Estados Unidos y México; los servicios profesionales más demandados; los requisitos para su prestación; así como las oportunidades de acceso y restricciones para los profesionistas mexicanos interesados en incorporarse. El argumento central es que uno de los sectores más dinámicos en la generación de empleo es el de servicios, y que éste a su vez presenta prioridades y particularidades entre los tres países. Por otra parte, no podemos soslayar que hay un aumento de la migración de mexicanos altamente calificados en relación con años anteriores. No obstante, una mayor movilidad de profesionistas en el mercado laboral de América del Norte sigue siendo un reto para México, pese a las negociaciones existentes, y más bien se ha caracterizado por cubrir las necesidades estratégicas de la economía de la región, donde también repercute la política migratoria de cada país. Finalmente, a manera de reflexión, se presentan los resultados indirectos de la migración de profesionales, como la fuga de cerebros.

  11. Protocolo quirúrgico en la reconstrucción de la parálisis facial: nuestra experiencia tras 140 casos tratados Protocol in surgical treatment of facial paralysis after 140 treated cases

    Directory of Open Access Journals (Sweden)

    B. Hontanilla Calatayud

    2008-09-01

    Full Text Available El objetivo de este trabajo es presentar nuestro protocolo de actuación en el tratamiento quirúrgico de la parálisis facial tras 140 casos tratados entre los años 2000 y 2007. Este protocolo está basado en los resultados obtenidos con un nuevo sistema de captura del movimiento facial en 3D denominado "Facial Clima", que puede ser considerado como un método objetivo de medición de los resultados en la cirugía de reanimación facial. Así podría compararse en pacientes con parálisis facial, la efectividad de los tratamientos entre distintos centros. Exponemos los resultados obtenidos tanto a nivel de la reconstrucción de la sonrisa como a nivel palpebral.The aim of this study is to present our protocol in the surgical treatment of facial paralysis after 140 treated cases since 2000 to 2007. The protocol is based on the results obtained with a new 3-D capture system of the facial movement called "Facial Clima", that could be considered as the adequate tool to assess the outcome of the facial paralysis reanimation surgery. Thus, patients with facial paralysis could be compared among surgical centres such that effectiveness of facial reanimation operations could be evaluated. The results obtained are exposed for smile and lid reconstruction.

  12. El reto de la contribución de la organización del Tratado de Cooperación Amazónica – OTCA– para el bienestar de las poblaciones locales y fronterizas

    Directory of Open Access Journals (Sweden)

    Fernando Franco Hernández

    2014-05-01

    Full Text Available El documento aborda la descripción de las dinámicas sociales, económicas y políticas de las poblaciones fronterizas asentadas en la Amazonia, que discurren en medio de situaciones de conflicto y con formas diferenciadas de presencia de los Estados nacionales y sus instituciones. El escrito expone las políticas de organismos multilaterales como la OTCA (Organización del Tratado de Cooperación Amazónica, que tienen como objetivo formular planes y agendas estratégicas en torno al desarrollo sostenible y al uso y conservación de los sistemas naturales amazónicos y sus recursos. El argumento central es que tales políticas, planes y programas tienen un impacto mínimo en la resolución de los problemas y conflictos que enfrentan los pueblos amazónicos, dada la ausencia de instrumentos que articulen las formulaciones de carácter general con propuestas y proyectos que conduzcan al desarrollo sostenible y a un mejor vivir de las poblaciones amazónicas a escala regional.

  13. La construcción de la bóveda de arista rectangular en el tratado de Gelabert: teoría y práctica

    Directory of Open Access Journals (Sweden)

    Senent-Domínguez, R.

    2013-10-01

    Full Text Available The groin vault is one of the most common types of vaults in Spain, designed to cover square spaces. When the groin vault is arranged on a rectangular plan, the vaulting system must be adapted to the new situation. This new arrangement multiplies the problems, entailing in different constructive solutions. This paper analyzes the theoretical model of the rectangular groin vault as proposed in stonecutting treatises (16th-18th centuries, focusing on the manuscript by Joseph Gelabert (17th century, and its relationship with vaults built in Palma de Mallorca from the 16th to the 18th century. Special attention is paid to the carving of the pieces of the groins by means of templates and their relationship to the “problem of the solid angle”, providing new data on a drawing in the manuscript of Hernán Ruiz the Younger (16th century.Entre los tipos de bóvedas más habituales del renacimiento español está la bóveda de arista, concebida para cubrir recintos cuadrados. Cuando la bóveda de arista se dispone sobre una planta rectangular, es necesario que el sistema de abovedamiento se adapte a esta nueva situación, lo que multiplica los problemas, dando lugar a diversas soluciones constructivas. Este artículo analiza el modelo teórico de bóveda de arista rectangular propuesto por los tratados de cantería de los siglos XVI-XVIII, centrándose en el manuscrito del mallorquín Joseph Gelabert (s. XVII, y su relación con bóvedas de este tipo construidas en la ciudad de Palma de Mallorca entre los siglos XVIXVIII. Se presta especial atención al problema de la labra de las dovelas de la arista por medio de plantillas y su relación con el “problema del ángulo sólido”, aportando nuevos datos sobre un dibujo del manuscrito de Hernán Ruiz el Joven (s. XVI.

  14. White versus blue: Does the wild 'albino' bilberry (Vaccinium myrtillus L.) differ in fruit quality compared to the blue one?

    Science.gov (United States)

    Zorenc, Zala; Veberic, Robert; Stampar, Franci; Koron, Darinka; Mikulic-Petkovsek, Maja

    2016-11-15

    Wild albino and blue bilberry fruit were analyzed to compare different fruit characteristics linked to the composition of primary and secondary metabolites. Compounds were identified using HPLC-MS and standard quality parameters were determined. Albino berries were significantly smaller, accumulated less water and were characterized by 23% higher dry weight. Soluble solids content and pH value were higher in albino bilberry and their surface was lighter and characterized by a yellow hue. Both bilberry forms accumulated identical individual sugars and organic acids; however, the albino form had 33% higher content of total sugars and 9% higher content of total organic acids compared to the blue type. Fifteen anthocyanins were identified in both forms, but in albino bilberries, individual anthocyanins were only detected in traces. Blue bilberry contained 1.6-fold higher levels of flavanols, 2.1-fold higher levels of flavonols, 2.5-fold higher levels of hydroxycinnamic acid derivatives and consequently, 4.6-fold higher total phenolic content. PMID:27283708

  15. Produtividade da mamona irrigada com esgoto doméstico tratado Productivity of castor bean irrigated with treated domestic sewage

    Directory of Open Access Journals (Sweden)

    Neyliane C. de Souza

    2010-05-01

    Full Text Available A mamoneira (Ricinus communis L., oleaginosa de relevante importância econômica e social no Nordeste, apresenta-se como alternativa para a produção do biodiesel. O experimento objetivou avaliar, em escala real, os aspectos produtivos da cultura da mamona irrigada com esgoto doméstico tratado. Empregou-se o sistema de microaspersão; a delimitação experimental foi de quatro repetições e quatro tratamentos: T1: água do poço e adubação recomendada; T2: esgoto doméstico tratado e adubação recomendada; T3: somente esgoto doméstico tratado e T4: esgoto doméstico tratado e metade da adubação recomendada. Verificou-se que as unidades irrigadas com esgoto tratado superaram as irrigadas com água, em quase todas as variáveis analisadas. A produtividade foi maior nos tratamentos irrigados com esgoto e adubação (T2 e (T4, alcançando produtividade de 1.986 e 1.412 kg ha-1, respectivamente. O teor de óleo contido nas sementes foi analisado e não apresentou nenhuma diferença significativa entre os tratamentos com adubação (T1, T2 e T4, sendo que o tratamento com esgoto tratado (T3 forneceu baixíssimos teores de óleo na semente.The castor bean (Ricinus communis L., an oil crop of economic and social importance for the Northeast region of Brazil, can be used for biodiesel production. The experiment aimed to evaluate, at a realistic scale, the productive aspects of the castor bean irrigated with treated sewage. Microsprinkler irrigation method was selected, and the experimental set-up consisted of four repetitions and four different treatments: well water and recommended fertilization (T1; treated wastewater and recommended fertilization (T2; treated wastewater without external recommended fertilization (T3; and treated wastewater and half of recommended fertilization (T4. It was found that units irrigated with treated sewage exceeded the ones irrigated with well water in almost all variables. The highest productivities were in the

  16. Lixiviação de metais pesados em solos tratados com lodo de esgoto

    Directory of Open Access Journals (Sweden)

    E. I. Bertoncini

    1999-09-01

    Full Text Available Foi realizado um experimento em tubos de percolação, utilizando-se três solos, classificados como Areia Quartzosa (AQ, Latossolo Vermelho-Amarelo (LV e Latossolo Vermelho-Escuro (LE, aos quais foram incorporadas sucessivas quantidades de lodo de esgoto, totalizando uma dose correspondente a 156,0 t ha-1 (base seca, num período de incubação de 310 dias. Após este período, os solos foram tratados com água ou com soluções de sais (KCl 0,9 mol L-1; KNO3 0,9 mol L-1; K2SO4 0,3 mol L-1 e Ca(NO32 0,3 mol L-1, adicionadas em quantidade correspondente a quatro vezes a capacidade de retenção de água dos solos. No líquido percolado pela passagem das soluções salinas, foram determinadas as quantidades de Cd, Cr, Cu, Ni e Zn presentes e, no percolado obtido com a passagem de água, além dos metais anteriormente citados, foram determinadas também as quantidades de Ca2+ e Mg2+. Os resultados permitiram observar que a adição de KCl provocou o arraste de 5% do Cd adicionado via lodo aos solos LV e LE; para os outros sais utilizados e para a água, esse arraste nunca foi superior a 2% do metal pesado adicionado via lodo. A retenção de Cd, Cu, Cr e Ni aumentou com a elevação dos teores de óxidos de Fe e Al presentes nos solos. Os elevados valores de pH e o aumento no teor de matéria orgânica proporcionado pela adição de lodo refletiram também na menor mobilidade dos metais. Os sais KCl e K2SO4 aumentaram a mobilidade de alguns dos metais estudados.

  17. Organizaciones internacionales y tratados asociativos: por una nueva clasificación de los sujetos de derecho internacional

    OpenAIRE

    Raphael Carvalho de Vasconcelos

    2015-01-01

    La personalidad jurídica es elemento fundamental para la actuación de un sujeto en el orden internacional. La efectiva participación en el espacio global no depende, sin embargo, sólo del cumplimiento de este requisito. Doctrina y jurisprudencia reconocen la personificación de las organizaciones internacionales actualmente sin grandes reservas, pero, ¿correspondería entender que cualquier tratado dotado de personería jurídica debe ser considerado investido de poderes para actuar en el orden i...

  18. Intoxicação aguda por triclorfon em caprinos tratados com a dose terapêutica

    OpenAIRE

    2014-01-01

    O presente estudo descreve um surto de intoxicação por triclorfon em caprinos, que receberam pela via oral, a dosagem terapêutica do princípio ativo em questão (100mg/kg), provenientes da Universidade Estadual de Maringá, campus de Umuarama, PR. Cinquenta e três ovinos foram tratados com a mesma formulação/solução e não se observou nenhum efeito colateral nos animais referente ao tratamento com triclorfon. Das 20 cabras medicadas, cerca de 40 minutos após a administração do triclorfon, oito a...

  19. Qualidade de caquis Fuyu tratados com cálcio em pré-colheita e armazenados sob atmosfera modificada

    OpenAIRE

    FERRI VALDECIR CARLOS; RINALDI MARIA MADALENA; LUCHETTA LUCIANO; ROMBALDI CESAR VALMOR

    2002-01-01

    Avaliou-se a eficiência do cálcio (CaCl2) na conservação de caquis Fuyu armazenados em temperatura ambiente (TA), atmosfera refrigerada (AR) e modificada (AM). Utilizou-se um delineamento inteiramente casualizado, com quatro repetições. Os caquizeiros foram tratados com 1% de CaCl2, em pulverizações de cobertura total, a cada 15 dias, a partir de 90 dias antes da data prevista para a colheita. Para a testemunha, pulverizaram-se as plantas com água destilada. As frutas foram colhidas com 65-75...

  20. EVALUATION OF ANTINOCICEPITVE ACTION OF PENTAZOCINE IN COMPARISION WITH MORPHINE IN ALBINO RATS

    Directory of Open Access Journals (Sweden)

    Manikanta

    2014-12-01

    Full Text Available : OBJECTIVES: To evaluate the antinociceptive effect of pentazocine in three graded doses (3, 6 and 12 mg/kg and its combination with morphine at sub-analgesic doses, and comparing their effect with analgesic dose of morphine (1mg/kg by tail flick method in albino rats. MATERIALS & METHODS: Tail flick method using analgesiometer and tail immersion test by hot water bath was selected for evaluating antinociceptive action of pentazocine and standard drug morphine. RESULTS: Pentazocine in the doses of 6mg/kg, 12 mg/kg intra peritoneal (i.p and morphine 1mg/kg i.p, produced significant antinociceptive effect in comparison to control by tail flick test and tail immersion test. Pentazocine 3 mg/kg, i.p and morphine 0.1 mg/kg, i.p had not produced significant antinociceptive action when given alone, but combination (pentazocine 3 mg/kg + morphine 0.1 mg/kg treatment produced significant antinociceptive effect in comparison to control. CONCLUSION: Pentazocine in the doses of 6 mg/kg, 12 mg/kg and their combination in low doses (pentazocine 3 mg/kg + morphine 0.1 mg/kg demonstrated significant antinociceptive activity in albino rats. Combination in low doses (pentazocine 3 mg/kg + morphine 0.1 mg/kg showed comparable antinociceptive activity with pentazocine 6 mg/kg in albino rats. STATISTICAL ANALYSIS: One way ANOVA and multiple comparison test (LSD was applied only to MPE% at 60 min.

  1. Potential of Pandanus odoratissimus as a CNS depressant in Swiss albino mice

    Directory of Open Access Journals (Sweden)

    Sama Raju

    2011-09-01

    Full Text Available In this study, several neuropharmacological effects of methanolic leaf extract of Pandanus odoratissimus (PO (family; Pandanaceae were studied in albino mice using various experimental models. The effect of PO on the CNS was studied by using different neuropharmacological paradigms including spontaneous motor activity, rota-rod performance and potentiation of Pentobarbital sodium sleeping time in albino mice. Preliminary phytochemical evaluation and acute toxicity studies were also carried out where LD50 >2000 mg/kg was considered non-toxic through acute exposure in rats by the oral route. The methanolic leaf extract (50,100 and 200 mg/kg i. p. produced a reduction in spontaneous motor activity, motor coordination and prolonged Pentobarbital sodium sleeping time. Preliminary qualitative chemical studies indicated the presence of steroids, saponins, terpinoids, glycosides, tannins, flavonoids and phenolics in the extract. These observations suggest that the leaf of Pandanus odoratissimus contains some active principles which possess potential CNS-depressant actionEstudaram-se alguns efeitos neurofarmacológicos do extrato metanólico de Pandanus odoratissimus (PO (família Pandanaceae em camundongos albinos, usando vários modelos experimentais. O efeito do PO no SNC foi estudado por meio de diferentes paradigmas neurofarmacológicos, como atividade motora espontânea, desempenho na haste rotatória e a potenciação do tempo de sono em camundongos albinos pelo pentobarbital sódico. A avaliação fitoquímica preliminar e os estudos de toxicidade aguda foram realizados e a DL50 >2000 mg/kg é considerada não tóxica, por meio da exposição aguda, por via oral, em ratos. O extrato metanólico de folha (50,100 e 200 mg/kg i. p. produziu redução da atividade motora espontânea, da coordenação motora e tempo prolongado de sono pelo pentobarbital sódico. Estudos químicos qualitativos preliminares indicaram a presença de esteróide, saponinas

  2. Experimental adiaspiromycosis in animals with a modified reactivity (Albino mice) after irradiation

    International Nuclear Information System (INIS)

    The nature of the pathologic process in experimental adiaspiromycosis, following intraperitoneal inoculation with elements of the mycelium phase of Emmonsia crescens Emmons et Jellison (1960), depends on the reactivity of the experimental animals. Compared with a control group of animals, inoculated albino mice (with a single dose of 250 rad) contracted adiaspiromycosis more readily, there was a higher incidence of positive findings, aleirospore dissemination to distant organs outside the abdominal cavity occurred earlier, the intensity of tissue and organ insemination of the host was much higher. The results of these studies show that individuals with low resistance and increased susceptibility to infection are particularly liable to contract adiaspiromycosis. (author)

  3. Contraceptive effect of Curcuma longa (L.) in male albino rat

    Institute of Scientific and Technical Information of China (English)

    PurohitAshok; BhagatMeenakshi

    2004-01-01

    Aim:To study the contraceptive effect of the crude extracts of Curcuma longa in male albino rats.Methods:Rats were fed orally with Curcuma longa aqueous and 70% alcoholic extract for 60 days (500 mg·kg-1·day-1).Results:A reduction in sperm motility and density was observed in both the treated groups.Conclusion:Curcuma longa may have affected the androgen synthesis either by inhibiting the Leydig cell function or the hypothalamus pituitary axis and as a result,spermatogenesis is arrested.(Asian J Androl 2004 Mar;6:71-74)

  4. Effect of cassava based diet on some heamatological parameters in albino rats fed petroleum contaminated diet

    Directory of Open Access Journals (Sweden)

    A O Adegoke

    2012-04-01

    Full Text Available The study was carried out to ascertain the effect of a cassava based diet (gari on crude oil heamato-toxicity in albino rats by feeding diet contaminated with various concentrations of crude oil mixed with 20% gari to determine the protective effect of gari. The haematological parameters haemoglobin (Hb, Packed cell volume (PCV and white blood cell count (WBC(Total and differential were monitored in the animals. Gari feeding at 20% caused insignificant dose dependent decrease in Hb and PCV but significant dose dependent white blood cell count in gari fed albino rats compared with Petroleum fed albino rats (P<0.05. Dose dependent decrease in Hb, PCV and white blood cell count was also observed in petroleum fed rats compared with their controls (P<0.05.  The study showed that ingestion of petroleum contaminated diet caused decreased haemoglobin (Hb, Packed cell volume (PCV and white blood cell count, an indicator of possible blood damage but supplementation of the diet with 20% gari decreased the haemoglobin (Hb, Packed cell volume (PCV and white blood cell count observed in petroleum fed albino rats. This study showed that feeding on gari diet did not reverse the damage caused by crude petroleum as evidenced by insignificant differences in Hb and PCV concentrations possibly as result of cyanide present in the gari.Industrial relevanceCassava is a staple food in human diets in over 80 countries (Gomez, et al 1988. Gari a starchy food prepared from cassava (Manihot utilisima tubers is one of the most popular staple foods of the people of the rain forest belt of West Africa. Gari contains mainly starch-20% amylase and 70% amylopectin having lost the soluble carbohydrates. Crude petroleum is capable of eliciting haemolytic toxicity of the blood cells in conditions of long- exposure causing decrease haemoglobin, white cell count and PCV levels. The study was carried out to see the effect of gari, a staple food on haemolytic toxicity caused by crude

  5. Sub-Acute Toxicity Studies of Paracetamol Infusion in Albino Wistar Rats

    Directory of Open Access Journals (Sweden)

    Anurag Payasi

    2010-04-01

    Full Text Available The objective of the present study was to evaluate the sub-acute toxicity of paracetamol infusion in albino wistar rats (male and female at different dose levels, ranging from 16 to 66 mg/kg body weight. No mortality was seen in any of the treatment groups during the course of study. Various physiological, hematological as well as biochemical parameters were studied and found not to be changed significantly, indicating that paracetamol infusion is non toxic even at higher dose level in wistar rats. Overall safety and tolerability profile of paracetamol infusion is proved good and does not appear to carry risk of serious adverse effects.

  6. Antioxidant Effect of Caffeic Acid on Oxytetracycline Induced Lipid Peroxidation in Albino Rats

    OpenAIRE

    Jayanthi, R.; Subash, P.

    2010-01-01

    Caffeic acid is a well-known phenolic compound widely present in plant kingdom. The aim of this study was to investigate the possible protective effect of caffeic acid (CA) against oxytetracycline (OXT) induced hepatotoxicity in male Albino Wistar rats. A total of 30 rats weighing 150–170 g were randomly divided into five groups of six rats in each group. Oral administration of OXT (200 mg/kg body weight/day) for 15 days produced hepatic damage as manifested by a significant increase in serum...

  7. COMBINED EFFECT OF WATER CONTAMINATION WITH COBALT AND NICKEL ON METABOLISM OF ALBINO (WISTAR) RATS

    OpenAIRE

    Z. Kechrid, F. Dahdouh, R. M. Djabar, N. Bouzerna

    2006-01-01

    The contamination of water by metal compounds is a worldwide environmental problem. Concentration of metals is widely related to biochemical values, which are used in diseases diagnosis due to environmental toxicity. The sub-chronic combined effects of nickel and cobalt on body weight gain and biochemical parameters were determined and compared with those of Ni (2+) or Co (2+) alone in 6 weeks male albino (Wistar) rats. Animals were given drinking solutions of NiSO4 6H2O [Ni (II) cation, LD50...

  8. Pharmacological evaluation of anti-fertility activity of ethanolic extract of Jatropha gossypifolia leaf in female albino mice

    Institute of Scientific and Technical Information of China (English)

    Sachin Jain; Gajendra Pratap Choudhary; Dinesh Kumar Jain

    2012-01-01

    Objective: Anti-fertility activity of ethanolic extract of Jatropha gossypifolia leaf in female albino mice. Methods: Jatropha gossypifolia leaf extract, when administered orally, altered the estrous cycle pattern in female mice, prolong the length of estrous cycle with significant increase in the duration of diestrus stage and reduced significantly the number of litters in albino mice. Treatment of mice with extract of 250 and 450 mg/kg body weight/day for 21 days caused a prolonged estrous cycle with significant increase in the duration of diestrus phase and elongation of estrus stage in treatment with higher dose (450 mg/kg body weight/day). Results: The analysis of the principal hormones involved in estrous cycle regulation showed that the plant extracts altered gonadrotrophin release (LH, FSH and prolactinn) and estradiol secretion. Conclusions:The results indicated the anti-fertility effect of Jatropha gossypifolia leaf extract in female albino mice.

  9. Reducción cerrada y osteosíntesis con agujas percutáneas en las fracturas del radio distal

    OpenAIRE

    Arenas Planelles, Antonio; Ortega Arruti, J.A.; Arenas Miquélez, A.; Ortega Sáez, M. (Marta)

    2009-01-01

    Se presentan 185 casos de fractura compleja del radio distal tratados con reducción ortopédica y estabilización con agujas de Kirschner introducidas de forma percutánea y asociadas a vendaje escayolado antebraquial. Los resultados funcionales finales fueron buenos o excelentes en 156 de los 185 casos (84,3%). Teniendo en cuenta los resultados, consideramos que el método es sencillo, útil y económico y debe valorarse su uso en la mayoría de las fracturas del radio distal. We report 185 case...

  10. Programas de intervención con menores hijos e hijas de mujeres víctimas de violencia de género

    OpenAIRE

    Pérez Caballero, M. Teresa; Díaz Rosado, Margarita

    2015-01-01

    En el citado seminario informaremos del programa de “atención integral a menores víctimas de violencia de género”, llevado a cabo por la Asociación DEMÉTER. A continuación, trataremos la formación en igualdad y prevención de violencia de género con los estudiantes, mediante charla, cuestionarios sobre conocimientos básicos en prevención de violencia de género, igualdad y menores. Terminaremos con un debate sobre los temas tratados. Universidad de Málaga. Campus de Excelencia Internac...

  11. Propuesta y análisis de un cuestionario complejo, basado en variables relacionadas con el paciente, dirigido a medir la percepción del tratamiento periodonta

    OpenAIRE

    Pulcini, Alberto

    2014-01-01

    Objetivo: Recientemente tanto en la investigación como en la clínica periodontal se ha incrementado el interés por el estudio de las variables centradas en el paciente. El objetivo de este estudio es medir el impacto de la terapia periodontal desde la perspectiva del sujeto tratado mediante la utilización y la organización de un nuevo cuestionario basado en variables relacionados con el paciente(QIPET). Material y Métodos: Se ha realizado un estudio transversal con análisis retrospectivo i...

  12. Diseñe su interfaz gráfica con Matlab

    Directory of Open Access Journals (Sweden)

    Miguel Ramón Ortegón Gutiérrez

    2011-01-01

    Full Text Available Las aplicaciones de carácter científico o tecnológico cuentan, para su desarrollo, con el apoyo de una poderosa herramienta de cálculo numérico, que permite abordar problemas que demanden variada y compleja manipulación matemática de manera eficiente y con ayudas gráficas. Su diseño funcional le permite usar con facilidad toda la gama de comandos en forma interactiva, o en modo programas que han sido implementados como parte del lenguaje, o los nuevos comandos implementados por el usuario. Problemas tradicionales, relativos al manejo de matrices o álgebra lineal, cálculo diferencial e integral, ecuaciones diferenciales, raíces de funciones, solución de sistemas de ecuaciones, etc., hasta algunos más especializados como el procesamiento digital de señales, redes neuronales, filtros, pueden ser tratados con este lenguaje. Con el presente artículo se desea difundir el uso de interfaces gráficas que provee Matlab, para hacer más modernas, presentables y manejables aplicaciones de ingeniería que con otras herramientas podrían resultar mas complicadas y engorrosas.

  13. Investigando con personas con dificultades de aprendizaje

    Directory of Open Access Journals (Sweden)

    Borja González Luna

    2013-12-01

    Full Text Available El artículo muestra los orígenes de lo que Walmsley (2008 denomina «investigación inclusiva». Para comprender qué se entiende por investigación inclusiva tenemos que remontarnos a los debates epistemológicos sobre las metodologías cuantitativas y cualitativas, acontecidos en la década de los 90, en torno a la revista Disability & Society. A partir de una síntesis de dichos debates, focalizados en el ámbito de la «discapacidad intelectual y del desarrollo», se exponen dos estrategias de colaboración con dicha población: a una aproximación etnográfica (de trabajo grupal, y b una aproximación biográfica (de trabajo individual. A continuación se esboza un posible diseño de trabajo de campo que intenta superar el paradigma cualitativo «clásico» con el objetivo de incluir a dicho colectivo más allá del rol de «sujetos de la investigación». Para finalizar se recoge el debate sobre la accesibilidad de los resultados de la investigación a los participantes en dichas investigaciones, y con ello la necesaria innovación en el ámbito de las «devoluciones» de los resultados, cuando se trata de incluir a personas que presentan limitaciones para la comprensión del lenguaje abstracto oral y/o escrito.

  14. Chemical variations observed in irradiated, treated with IPC and control potato tubers; Variaciones quimica observadas en tuberculos de patata irradiados, tratados con IPC y testigo

    Energy Technology Data Exchange (ETDEWEB)

    Mazon Matanzo, M. P.; Fernandez Gonzalez, J.

    1976-07-01

    The content in soluble sugars, ascorbic acid and phenolic acids of potato tubers preserved by irradiation and IPC, during storage period of five months are studied. In the irradiated tubers, soluble sugars increased immediately after the irradiation, in relation to the control tubers reaching inferior values to those reached by the control tubers, at the end of the storage period. The content in ascorbic acid is generally kept higher in the irradiated and IPC treated tubers than in the control tubers and the content in phenolic acids increased in the irradiated and IPC treated tubers by immediate effect of this treatment. (Author) 39 refs.

  15. Estudio del virus JC, agente causal de la leucoencafalopatía multifocal progresiva, en pacientes de esclerosis múltiple recurrente-remitente tratados con Natalizumab

    OpenAIRE

    Domínguez Mozo, María Inmaculada

    2013-01-01

    La esclerosis múltiple (EM) es una enfermedad desmielinizante inflamatoria crónica que afecta al sistema nervioso central (SNC) y cuyo origen es presumiblemente autoinmune, siendo en los países desarrollados la segunda causa de discapacidad entre personas jóvenes después de los accidentes de tráfico. Durante los últimos años se han desarrollado, o actualmente están en ensayo clínico, una gran cantidad de fármacos para tratar esta patología. Entre todos ellos cabe destacar natalizumab, u...

  16. Resistencia antimicrobiana en aislados de "Escherichia coli" de conejos tratados por vía oral con diferentes pautas de doxiciclina

    OpenAIRE

    Medina Landaeta, Alberto Enrique

    2011-01-01

    La resistencia a antimicrobianos constituye actualmente un problema de gran impacto en Salud Pública. El excesivo uso de antimicrobianos en medicina humana y veterinaria y en agricultura ha originado un incremento continuo de fracasos en la terapia antimicrobiana debido al aumento y diversidad de microorganismos resistentes. La evaluación del riesgo del desarrollo de resistencias cobra especial interés cuando se utilizan pautas de administración por vía oral en animales de abasto, por cuan...

  17. Los menores no punibles : ¿Resulta compatible su situación legislativa con la constitución nacional y tratados internacionales incorporados a ella?

    OpenAIRE

    Anselmino, Valeria L.

    2014-01-01

    El fenómeno de la mal llamada “Delincuencia de Menores” no deja de ser portada de diarios y revistas, como así tampoco es ajena al tratamiento doctrinario y legislativo. La vida moderna muestra a nuestros jóvenes una serie de expectativas y objetivos, de difícil acceso a través de los medios convencionales. La sensación de frustración y de falta de incentivos en que los mismos se ven envueltos resultan el empujón final hacia el camino del delito. A lo que se suma la crisis de la familia, e...

  18. Urgencias metabólicas en pacientes críticos con cáncer

    Directory of Open Access Journals (Sweden)

    Silvio A. Ñamendys-Silva

    2013-12-01

    Full Text Available Las alteraciones metabólicas graves que ocurren con frecuencia en pacientes oncológicos críticamente enfermos incluyen: hipercalcemia, hipocalcemia, hiponatremia, síndrome de lisis tumoral, alteraciones metabólicas asociadas a insuficiencia renal y acidosis láctica. Los enfermos oncológicos con urgencias metabólicas deben ser tratados en un departamento de oncología médica o en una unidad de cuidados intensivos. La mayor parte de las urgencias metabólicas se pueden tratar de forma adecuada cuando son identificadas de forma temprana. El clínico debe considerar, que el pronóstico de los pacientes oncológicos críticamente enfermos depende de su enfermedad primaria, las comorbilidades y las fallas orgánicas.

  19. Evaluation of antinociceptive effect of Xanthium strumarium Linn. leaves extract in Swiss albino mice

    OpenAIRE

    Akarte Atul; Bhagat Vishwas; Deshmukh Pradeep; Disle Chandrakant

    2009-01-01

    The aim of this study was to explore the probable antinociceptive effect of an ethanolic extract of Xanthium strumarium L. leaves in Swiss albino mice by using models of Eddy′s hot plate test, tail immersion test and acetic acid induce writhing test. Swiss albino mice were treated i.p. with saline water (control), test group treated with 50, 100, 200 and 400 mg/kg extract per oral, standard group treated with pentazocin 3 mg/kg. The results are expressed as the mean ± SEM. and...

  20. Evaluación urodinámica con doxazocina en pacientes con hiperplasia prostática benigna (HPB. Hospital Pablo Tobón Uribe (HPTU de 1998-1999

    Directory of Open Access Journals (Sweden)

    Juan Aristizábal

    2001-04-01

    Full Text Available

    Tradicionalmente la HPB ha sido tratada quirúrgicamente, pero a
    partir de los años 80 ha aparecido una gran variedad de modalidades
    terapéuticas diferentes a la cirugía, basadas en medicamentos orales que disminuyen el tamaño de la próstata y/o los síntomas que esto genera.
    Se propone estudiar con todos los parámetros urodinámicos, la respuesta de los pacientes con HPB tratados con Doxazocina para evaluar su efecto en las curvas Flujo-Presión.

     

     

  1. The Protective Role of Ginger (Zingiber Officinales ) in Male Albino Rats Exposed to Gamma Irradiation

    International Nuclear Information System (INIS)

    The present work was performed to evaluate the effectiveness of preirradiation treatment with ginger (Zingiber Officinales) for 21 consecutive days before exposure in controlling post-irradiation hazards in male rats. Male albino rats weighing about 120±10 g were divided into four groups: ( I ) control, ( II ) treated with ginger 200 mg/kg , ( III ) irradiated with 6 Gy and ( IV ) treated with ginger 200 mg/kg before irradiated with 6 Gy gamma - radiation . The blood samples were collected from heart of animals 21 days after treatment with ginger and seven days post irradiation. Blood samples were subjected to biochemical analysts such as liver functions , lipid profile , kidney function and sex hormone. Whole body gamma irradiation of rats at 6 Gy (single dose) caused significant increase in (aspartate and alanine aminotransferases (AST and ALT), cholesterol, triglycerides , glucose, urea and creatinine) while alkaline phosphatase showed no effect. Irradiation caused decrease in the contents of total protein , albumin and testosterone. Ginger treatment exerted noticeable amelioration in the studied biochemical parameters of the irradiated albino rats. The mechanism of action of ginger may be due to its antiinflammatory properties against whole body gamma irradiation

  2. Immunomodulatory Activity of Vetiveria zizanioides Extract on Peritonial Macrophages of Albino Mice

    Directory of Open Access Journals (Sweden)

    Sunitha VS

    2015-12-01

    Full Text Available Vetiveria zizanioides L. (Poaceae is a medicinal plant which is used as a thirst quencher in southern part of India especially in Kerala. The present study was conducted to scientifically evaluate the effects of extracts of V. zizanioides on phagocytic function of macrophages. In vivo effect of aqueous, ethanol and hexane extract of the plant at two doses (10mg/kg body weight and 25mg/kg b.w. were evaluated by oral administration of the extracts on Swiss albino male mice. In vitro immunomodulatory potential of the above extracts at different concentrations (10μg/ml, 25μg/ml, 50 μg/ml and 100μg/ml was studied using peritoneal macrophages from Swiss albino mice. All extracts gave phagocytic modulation in vivo. The aqueous extract of vetiveria zizanoides at a dose of 25mg/kg b.w. showed significant (p<0.05 increase in phagocytic activity in comparison with the control. An increased phagocytic response was shown by murine peritoneal macrophages after treatment with the extracts in vitro. A dose dependent response was observed in all cases. The results of the present study indicate the immunomodulatory effect of V. zizanioides extracts on murine peritoneal macrophages, as evidenced by its effect on phagocytosis which is a nonspecific immune mechanism.

  3. Effect of chronic exposure to aspartame on oxidative stress in the brain of albino rats

    Indian Academy of Sciences (India)

    Ashok Iyyaswamy; Sheeladevi Rathinasamy

    2012-09-01

    This study was aimed at investigating the chronic effect of the artificial sweetener aspartame on oxidative stress in brain regions of Wistar strain albino rats. Many controversial reports are available on the use of aspartame as it releases methanol as one of its metabolite during metabolism. The present study proposed to investigate whether chronic aspartame (75 mg/kg) administration could release methanol and induce oxidative stress in the rat brain. To mimic the human methanol metabolism, methotrexate (MTX)-treated rats were included to study the aspartame effects. Wistar strain male albino rats were administered with aspartame orally and studied along with controls and MTX-treated controls. The blood methanol level was estimated, the animal was sacrificed and the free radical changes were observed in brain discrete regions by assessing the scavenging enzymes, reduced glutathione, lipid peroxidation (LPO) and protein thiol levels. It was observed that there was a significant increase in LPO levels, superoxide dismutase (SOD) activity, GPx levels and CAT activity with a significant decrease in GSH and protein thiol. Moreover, the increases in some of these enzymes were region specific. Chronic exposure of aspartame resulted in detectable methanol in blood. Methanol per se and its metabolites may be responsible for the generation of oxidative stress in brain regions.

  4. A comparative study on the susceptibility of male and female albino mice to Trypanosoma brucei brucei

    Directory of Open Access Journals (Sweden)

    A.A. Turay, G.O. Nwobu, G.R.A. Okogun, C.U. Igwe, K. Adeyeye, K.E. Aghatise, H.O. Okpal & Y.M. Tatfeng

    2005-03-01

    Full Text Available Background & objectives: Trypanosomiasis has remained a major set-back in the development oflivestock farming in tropical Africa. Thus the need for ascertaining the trypanotolerant levels ofdomestic animal breeds and possible improvement on them cannot be over-emphasised.Methods: Level of trypanotolerance in animals was compared between sexes using albino mice infectedwith a Nigerian strain of Trypanosoma brucei brucei at a 50% mouse lethal dose (MLD50.Results: The male mice showed unrestrained parasite growth with a prepatent period (PP of two daysand a mean survival period (MSP of six days corresponding to a gradual decrease in packed cellvolume (PCV, body weight, diet response and white blood cells (WBC count to the time of death.Their female counterparts showed a PP of three days and MSP of ten days with a similar PCV gradientbut a refractory WBC count. There was no significant difference in the differential leucocytes countin both sexes. However, the eosinophils count was significantly higher in the infected animals. It wasfound that female albino mice exercised more parasite restraint than their male counterparts.Interpretation & conclusion: The result suggests that the female animals may be more trypanotoleranthence may be more useful in protein production in trypanosomiasis endemic areas. However, furtherresearch using large domestic breeds like goats and sheep may be required to confirm the hypothesis.

  5. Wound healing activity of methanolic stem extract of Musa paradisiaca Linn. (Banana) in Wistar albino rats.

    Science.gov (United States)

    Amutha, Kuppusamy; Selvakumari, Ulagesan

    2016-10-01

    This study is designed to explore the phytochemical, antibacterial and wound healing activity of methanolic stem extract of Musa paradisiaca Linn. (Banana). The phytochemical analysis was performed for the methanolic stem extract of Musa paradisiaca Linn. Results indicates that the Musa paradisiaca Linn. was rich in glucosides, tannins and alkaloids, saponins, flavonoids and phenols were present in moderate quantities. The extract shows antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus with the zone of inhibition of Pseudomonas aeruginosa was 21 mm and Staphylococcus aureus was 19 mm at concentration of 500 µg/disc. The minimum inhibitory concentration (MIC) was also evaluated for the extract. Wistar albino rats were selected for wound healing activity. The burn wound was created by using red hot steel rod from above the hind limb region. The methanolic extract was applied on the wound and the progressive changes were monitored every day. The wound contraction rate was absorbed based on the histopathological examination. It was concluded that the methanolic extract of Musa paradisiaca Linn. showed greater healing activity compared to control in Wistar albino rats.

  6. Amelioration of cisplatin induced nephrotoxicity in Swiss albino mice by Rubia cordifolia extract

    Directory of Open Access Journals (Sweden)

    Joy Jisha

    2008-01-01

    Full Text Available Background: Cisplatin is one of the most effective chemotherapeutics against a wide range of cancers including head, neck, ovarian and lung cancers. But its usefulness is limited by its toxicity to normal tissues, including cells of the kidney proximal tubule. The purpose of the present study is to investigate whether the hydro-alcoholic extract of Rubia cordifolia could decrease the intensity of toxicity in Swiss albino mice. Materials and Methods: Cisplatin at a dose of 12 mg/kg body wt was administered intraperitoneally to Swiss albino mice. Another set of animals was given hydro-alcoholic extract of Rubia cordifolia at different doses along with cisplatin treatment. The antioxidant levels, serum creatinine, serum urea etc. were analyzed. Results: The extract could significantly decrease the cisplatin induced nephrotoxicity as inferred from the tissue antioxidant status in the drug administered animals. Remarkable change was observed in serum creatinine and urea levels. Lipid peroxidation in the kidney and liver tissues was also considerably reduced in Rubia cordifolia extract treated animals. Conclusion: Hydro-alcoholic extracts of Rubia cordifolia are effective in reducing the renal damage caused by the cancer chemotherapeutic drug cisplatin. Since Rubia cordifolia has been in use as an important ingredient in the traditional Ayurvedic system of medicine, it could be safe and beneficial to use this herbal extract as an adjuvant to ameliorate renal damage in patients undergoing cancer chemotherapy with cisplatin.

  7. Effect of imatinib on the biochemical parameters of the reproductive function in male Swiss albino mice

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    A M Prasad

    2011-01-01

    Full Text Available Background: Treatment of cancers with cytotoxic agents such as tyrosine kinase inhibiting drugs often, but not always, result in transient to permanent testicular dysfunction. Germ cells are important targets of many chemicals. Most of the drugs are genotoxins and induce irreversible effect on genetic makeup. These mutagenic changes are proportionally related to carcinogenesis. This is alarmingly dangerous in youth and children, since these effects last longer, affecting fertility or forming basis for carcinogenesis. There is paucity of reports on planned studies of imatinib on the testicular function. Hence, the study was planned to assess the effects of imatinib on biochemical markers of testicular functions in male Swiss albino mice. Materials and Methods: Male Swiss albino mice were treated with imatinib and sacrificed at the end of first, second, fourth, fifth, seventh, and tenth week after the last exposure to imatinib. The testis were removed, weighed, and processed for biochemical analysis. Results: The intratesticular testosterone level was significantly (P<0.001 reduced in treated groups and severe effect was observed on week 4 and 5. The intratesticular lactate dehydrogenase (LDH level was significantly increased by imatinib in all treated groups up to week 5. Conclusion: Imatinib does affect testosterone and LDH level significantly, but this effect is reversible once the drug is withdrawn. This finding may help the clinicians to plan and address the fertility-related issues in young patients of reproductive age who are being treated with imatinib for gastrointestinal tumors and chronic myeloid leukemia.

  8. Assessment of imidacloprid-induced mutagenic effects in somatic cells of Swiss albino male mice.

    Science.gov (United States)

    Bagri, Preeti; Kumar, Vinod; Sikka, Anil K

    2016-10-01

    Pesticides are being used for plant protection to increase food protection and to reduce insect-borne diseases worldwide. Exposure to the pesticides may cause genotoxic effects on both the target and nontarget organisms, including man. Therefore, the mutagenicity evaluation of such pesticides has become a priority area of research. Imidacloprid (IMI), a neonicotinoid insecticide, is widely used in agriculture either alone or in combination with other insecticides. A combined approach employing micronucleus test (MNT) and chromosomal aberrations assay (CA) was utilized to assess the mutagenicity of imidacloprid in bone marrow of Swiss albino male mice. IMI suspension was prepared in 3% gum acacia and administered at doses of 5.5, 11 and 22 mg/kg body weight for 7, 14 and 28 days to mice. IMI treatment resulted in a dose and time-dependant increase in the frequencies of micronuclei per cell and chromosomal aberrations in bone marrow cells. A statistically significant increase in chromosomal aberrations and micronuclei/cell was found only after daily treatment of IMI at highest selected dose (22 mg/kg body weight) for longest selected time period (28 days) compared to the control group. Thus, daily exposure of imidacloprid at a dose level of 22 mg/kg body weight for 28 days caused mutagenic effects on the somatic cells of Swiss albino male mice.

  9. Acute effect of aspartame-induced oxidative stress in Wistar albino rat brain.

    Science.gov (United States)

    Ashok, Iyaswamy; Sheeladevi, Rathinasamy; Wankhar, Dapkupar

    2015-09-01

    The present study was carried out to investigate the acute effect of aspartame on oxidative stress in the Wistar albino rat brain. We sought to investigate whether acute administration of aspartame (75 mg/kg) could release methanol and induce oxidative stress in the rat brain 24 hours after administration. To mimic human methanol metabolism, methotrexate treated rats were used to study aspartame effects. Wistar strain male albino rats were administered with aspartame orally as a single dose and studied along with controls and methotrexate treated controls. Blood methanol and formate level were estimated after 24 hours and rats were sacrificed and free radical changes were observed in discrete regions by assessing the scavenging enzymes, reduce dglutathione (GSH), lipid peroxidation and protein thiol levels. There was a significant increase in lipid peroxidation levels, superoxide dismutase activity (SOD), glutathione peroxidase levels (GPx), and catalase activity (CAT) with a significant decrease in GSH and protein thiol. Aspartame exposure resulted in detectable methanol even after 24 hours. Methanol and its metabolites may be responsible for the generation of oxidative stress in brain regions. The observed alteration in aspartame fed animals may be due to its metabolite methanol and elevated formate. The elevated free radicals due to methanol induced oxidative stress.

  10. Effect of chronic exposure to aspartame on oxidative stress in the brain of albino rats.

    Science.gov (United States)

    Iyyaswamy, Ashok; Rathinasamy, Sheeladevi

    2012-09-01

    This study was aimed at investigating the chronic effect of the artificial sweetener aspartame on oxidative stress in brain regions of Wistar strain albino rats. Many controversial reports are available on the use of aspartame as it releases methanol as one of its metabolite during metabolism. The present study proposed to investigate whether chronic aspartame (75 mg/kg) administration could release methanol and induce oxidative stress in the rat brain. To mimic the human methanol metabolism, methotrexate (MTX)-treated rats were included to study the aspartame effects. Wistar strain male albino rats were administered with aspartame orally and studied along with controls and MTX-treated controls. The blood methanol level was estimated, the animal was sacrificed and the free radical changes were observed in brain discrete regions by assessing the scavenging enzymes, reduced glutathione, lipid peroxidation (LPO) and protein thiol levels. It was observed that there was a significant increase in LPO levels, superoxide dismutase (SOD) activity, GPx levels and CAT activity with a significant decrease in GSH and protein thiol. Moreover, the increases in some of these enzymes were region specific. Chronic exposure of aspartame resulted in detectable methanol in blood. Methanol per se and its metabolites may be responsible for the generation of oxidative stress in brain regions.

  11. HAIR GROWTH POTENTIAL OF EVOLVULUS ALSINOIDES LINN. PLANT EXTRACT IN ALBINO RATS

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    Bhaiji Amrita

    2012-05-01

    Full Text Available Evolvulus alsinoides Linn. (Convolvulaceae is traditionally used for its hair growth promoting activity in rural community of Indian sub-continent. Studies were therefore carried out to evaluate petroleum ether and methanolic extracts of Evolvulus alsinoides for their effect on hair growth in albino rats. The extracts were incorporated into oleaginous base and applied topically on shaved denuded skin of albino rats for thirty days. The time required for hair growth initiation and completion was significantly (P < 0.01 reduced. Minoxidil 2% solution applied topically served as positive control. The treatment was successful in bringing 73% of hair follicles in anagenic phase by application of 5% methanolic extract as comparable to standard. Bioactivity guided fractionation was carried out of methanolic extract and was fractionated as aqueous and non-aqueous extract and screened pharmacologically. Water insoluble methanolic extract was found to be more potent and reduced the hair growth initiation and completion time significantly (P < 0.01 as comparable to standard. It holds the promise of potent alternative for minoxidil.Keywords:

  12. Effect of Some Antioxidants on the Physical Fitness of Albino Rats

    International Nuclear Information System (INIS)

    In recent years, more attention has been paid for searching of natural antioxidants and their evaluation in either medicinal practice or as food raw materials. The aim of the present research is to assess the effect of several well-known products used as antioxidants, on body weight, haemopoesis, endocrine system and lipid profile in normal albino rats. Thirty male adult albino rats were equally arranged into 5 groups, the first group was served as control and the others received special treatments where taurine (2% in drinking water), tryptophan (100 mg/kg b.w. orally), hawthorn extract (50 mg/100 g b.w. orally) and coenzyme Q10 (50 mg/kg b.w. orally) were given for two months. Body weight was regularly recorded twice a week and at the end of the experiment, the rats were decapitated. Red blood cell count (RBCs), hemoglobin (Hb) content, reticulocytic count, white blood cell count (WBCs) and glutathione (GSH) concentration were estimated in blood, while, triiodothyronine (T3), thyroxin (T4), Testosterone, and corticosterone hormones besides lipid profile were estimated in the serum. The results denoted that although there is a slight improvement in the parameters tested, it does not deserve the coast of the regular use of these antioxidants and further investigations still needed

  13. Effect of GABAB Receptor Antagonist (CGP35348 on Learning and Memory in Albino Mice

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    Quratulane Gillani

    2014-01-01

    Full Text Available The present study was designed to demonstrate the potential effect of CGP 35348 (GABAB receptor antagonist on the learning, memory formation, and neuromuscular coordination in albino mouse. Mice were intrapertoneally injected with 1 mg CGP 35348/mL of distilled water/Kg body weight, while the control animals were injected with equal volume of saline solution. A battery of neurological tests was applied following the intrapertoneal injections. Results of rota rod indicated that CGP 35348 had no effect on neuromuscular coordination in both male (P=0.528 and female (P=0.125 albino mice. CGP 35348 treated females demonstrated poor exploratory behavior during open filed for several parameters (time mobile (P=0.04, time immobile (P=0.04, rotations (P=0.04, and anticlockwise rotations (P=0.038. The results for Morris water maze (MWM retention phase indicated that CGP 35348 treated male mice took shorter latency to reach the hidden platform (P=0.04 than control indicating improved memory. This observation was complemented by the swim strategies used by mice during training days in MWM as CGP 35348 treated males used more direct and focal approach to reach the platform as the training proceeded.

  14. Ameliorative effect of grapefruit juice on amiodarone-induced cytogenetic and testicular damage in albino rats

    Institute of Scientific and Technical Information of China (English)

    Saber Abdelruhman Sakr; Mohamed El-said Zoil; Samraa Samy El-shafey

    2013-01-01

    Objective:To evaluate the ameliorative role of grapefruit juice on the cytogenetic and testicular damage induced by the antiarrythmic drug amiodarone in albino rats. Methods: Animals were divided into four groups. Group I was considered as control. Group II was given grapefruit juice at a dose level of 27 mL/kg body weight. Group III was orally administered amiodarone (18 mg/kg body weight) daily for 5 weeks. Animals were sacrificed after 5 weeks of treatment. Bone marrow was collected from the femurs for analysis of chromosomal aberrations and mitotic indices. Testes were removed and stained with H&E for histological examination. Sperms were collected from epidedymis for detection of sperm head abnormalities. Comet assay was used to detect DNA damage. Results: Amiodarone treatment caused a significant increase in the percentage of chromosomal aberrations, decreased the mitotic index and increased DNA damage. The testis showed many histopathological alterations, inhibition of spermatogenesis and morphometric changes. The number of sperm head abnormalities was increased. Treating animals with amiodarone and grapefruit juice caused a reduction in chromosomal aberrations, mitotic index, DNA damage and testicular alterations caused by amiodarone. Conclusions:The results of this study indicated that grapefruit juice ameliorates the cytotoxicty and testicular alterations induced by amiodarone in albino rats and this is may be due to the potent antioxidant effects of its components.

  15. Impact on behavioral changes due to chronic use of sertraline in Wistar albino rats

    Directory of Open Access Journals (Sweden)

    Shatavisa Mukherjee

    2015-01-01

    Full Text Available Aim: Despite having better tolerability and a wide range of clinical applications over other antidepressants, selective serotonin reuptake inhibitors (SSRIs are also known to be associated with serious adverse effects like suicidal ideation on chronic use. The present study had explored the impact of the chronic use of sertraline, an SSRI, on the behavioral changes in Wistar albino rats. Materials and Methods: The study was conducted on 30 Wistar albino rats of either sex; divided into five groups. Four groups were subjected to chronic mild stress induced by using various stressors randomly scheduled in a week and continued for a period of 3 weeks. The stressed rodents were subjected to sertraline treatment for 9 weeks in different human therapeutic doses extrapolated to animal doses. Behavioral changes were monitored, assessed, and evaluated throughout the treatment phase with the help of tests such as locomotor activity test, forced swim test, tail suspension test, antianxiety test, and sucrose preference test (SPT. Results: All tests except SPT, demonstrated significant (P < 0.05 reduction in depressive-like activity in the stressed rodents by the mid-treatment phase, followed by an abrupt onset of the depressive state by the end of the treatment phase. SPT showed a significant (P < 0.05 increase in sucrose consumption throughout the treatment phase. Conclusion: Behavioral changes following chronic sertraline administration conferred gradual remission of depression state on initial treatment phase, followed by a reversal of effect on chronic use.

  16. Hematobiochemical changes of lead Poisoning and amelioration with Ocimum sanctum in wistar albino rats

    Directory of Open Access Journals (Sweden)

    Anjaneyulu Y.

    2011-12-01

    Full Text Available An experiment was carried out to study the hematobiochemical changes of chronic lead poisoning in adult male wistar albino rats for a period of twelve weeks. Adult 216 healthy rats were randomly divided into six groups viz. control (groupI, higher dose of lead acetate @60mgs/kg bwt (group II, Lower dose of lead acetate @ 30 mgs / kg bwt (group III, Higher dose of lead + Ocimum @ 400 mgs/ kg bwt (group IV, lower dose of lead + Ocimum @ 400 mgs/ kg bwt (group V, Ocimum control (group VI. All lead treated and ameliorated groups given Lead acetate/ lead + Ocimum orally for three days in a week for a period of twelve weeks. The mean PCV, Hb, values were reduced significantly (P<0.05 in lead treated rats as dose dependent manner. Where as significant improvement was noticed in Ocimum treated groups Increased TLC and PLC values as dose dependent manner. A significant reduction in PNC was noticed in ocimum treated groups. Significant (P<0.05 decrease in serum total protein values, serum glucose and increased creatinine values were observed in lead treated groups as dose dependent . Increased protein & glucose and decreased creatinine values obtained in Ocimum treated groups. The alterations in hematological and biochemical parameters in the present study indicates decreased lifespan & fragility of RBC and damage to liver, kidney and Pancreas in lead poisoned wistar albino rats. [Vet. World 2011; 4(6.000: 260-263

  17. Dietary Antioxidants Effectiveness on Carbon Tetrachloride-Induced Hepatotoxicity in Adult Female Albino Rats

    International Nuclear Information System (INIS)

    Hepatic toxicity through carbon tetrachloride (CCI4) induced lipid peroxidation was extensively used in experimental models to understand the cellular mechanisms behind oxidative damage and to evaluate the therapeutic potential of drugs and dietary antioxidants. The ameliorative effect of Aloe vera juice and carrot supplementation on hepato carcinogenesis induced by carbon tetrachloride in adult female albino rats was investigated. The carcinogenic process was determined by measuring gamma-glutamyl transpeptidase (GGT), ornithine carbamyl transferase (OCT), thiobarbituric acid reactive substances (TBARs), representing levels of lipid peroxides, and carcinoembryonic antigen (CEA) in the sera of female albino rats. Carbon tetrachloride significantly elevated the serum GGT, OCT activities and the level of TBARs. Administration of Aloe vera leaf juice filtrate after CCl4 treatment resulted in a non-significant modification in GGT, OCT activities and significantly improved the level of TBARs in comparison with control. Supplementation of carrot to CCI4 treated animals led to a great amelioration in OCT activity and TBARs level, whereas GGT activity was ameliorated but statistically changed compared to control. There was a non-significant alteration in the level of CEA in all treated groups compared to normal control one

  18. Effect of Stem Cell Therapy on Amiodarone Induced Fibrosing Interstitial Lung Disease in Albino Rat

    Science.gov (United States)

    Zaglool, Somaya Saad; Zickri, Maha Baligh; Abd El Aziz, Dalia Hussein; Mabrouk, Doaa; Metwally, Hala Gabr

    2011-01-01

    Background and Objectives: The fibrosing forms of interstitial lung disease (ILD) are associated with significant morbidity and mortality. ILD may be idiopathic, secondary to occupational, infection, complicate rheumatic diseases or drug induced. Efficacy of antifibrotic agents is as far as, limited and uncertain. No effective treatment was confirmed for pulmonary fibrosis except lung transplantation. The present study aimed at investigating the possible effect of human cord blood mesenchymal stem cell (MSC) therapy on fibrosing ILD. This was accomplished by using amiodarone as a model of induced lung damage in albino rat. Methods and Results: Seventeen adult male albino rats were divided into 3 groups. Rats of amiodarone group were given 30 mg/kg of amiodarone orally 6 days/ week for 6 weeks. Rats of stem cell therapy group were injected with stem cells in the tail vein following confirmation of lung damage and left for 4 weeks before sacrifice. Obstructed bronchioles, thickened interalveolar septa and thickened wall of pulmonary vessels were found and proved morphometrically. Reduced type I pneumocytes and increased area% of collagen fibers were recorded. All findings regressed on stem cell therapy. Conclusions: Cord blood MSC therapy proved definite amelioration of fibrosing interstitial lung disease provided therapy starts early in the development of the pathogenesis. PMID:24298346

  19. Assessment of imidacloprid-induced mutagenic effects in somatic cells of Swiss albino male mice.

    Science.gov (United States)

    Bagri, Preeti; Kumar, Vinod; Sikka, Anil K

    2016-10-01

    Pesticides are being used for plant protection to increase food protection and to reduce insect-borne diseases worldwide. Exposure to the pesticides may cause genotoxic effects on both the target and nontarget organisms, including man. Therefore, the mutagenicity evaluation of such pesticides has become a priority area of research. Imidacloprid (IMI), a neonicotinoid insecticide, is widely used in agriculture either alone or in combination with other insecticides. A combined approach employing micronucleus test (MNT) and chromosomal aberrations assay (CA) was utilized to assess the mutagenicity of imidacloprid in bone marrow of Swiss albino male mice. IMI suspension was prepared in 3% gum acacia and administered at doses of 5.5, 11 and 22 mg/kg body weight for 7, 14 and 28 days to mice. IMI treatment resulted in a dose and time-dependant increase in the frequencies of micronuclei per cell and chromosomal aberrations in bone marrow cells. A statistically significant increase in chromosomal aberrations and micronuclei/cell was found only after daily treatment of IMI at highest selected dose (22 mg/kg body weight) for longest selected time period (28 days) compared to the control group. Thus, daily exposure of imidacloprid at a dose level of 22 mg/kg body weight for 28 days caused mutagenic effects on the somatic cells of Swiss albino male mice. PMID:26823062

  20. Traffic Noise: A Silent Killer of Male Gamate of Albino Rats

    Directory of Open Access Journals (Sweden)

    Purushottam Pramanik , Snehangshu Biswas

    2012-01-01

    Full Text Available Objectives: The study aims to estimate the change in the weight of testis, sperm count, sperm morphology, testicular cholesterol and protein level in acute and chronic traffic noise exposed albino rats. Background: Road traffic is a significant source of noise pollution, a type of environmental stress. Traffic noise significantly increases adrenal cortical function and causes testicular dysfunction. Method: Experiment was performed on adult male albino rats. Animals were divided in to one control group and two experimental groups. Both the experimental groups were exposed to traffic noise having intensity 80 dB to 90 dB at the rate of 5 hr daily and control group was not exposed. First experimental group was exposed to traffic noise for 30 days and second group for 60 days. Testicular weight, sperm count, sperm morphology, testicular protein level and testicular cholesterol level were estimated. Statistical analysis was done using unpaired ‘t’ test. Result: Contribution of testis to body weight, testicular protein level and sperm count were low but testicular cholesterol level was more in traffic noise exposed rats than unexposed counterpart. Traffic noise exposure also increased percentage of morphologically abnormal sperm. Conclusion: Traffic noise adversely affect male gamete and such effect may be due to noise-induced suppression of testosterone synthesis.

  1. Evaluation of antinociceptive effect of Xanthium strumarium Linn. leaves extract in Swiss albino mice

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    Akarte Atul

    2009-01-01

    Full Text Available The aim of this study was to explore the probable antinociceptive effect of an ethanolic extract of Xanthium strumarium L. leaves in Swiss albino mice by using models of Eddy′s hot plate test, tail immersion test and acetic acid induce writhing test. Swiss albino mice were treated i.p. with saline water (control, test group treated with 50, 100, 200 and 400 mg/kg extract per oral, standard group treated with pentazocin 3 mg/kg. The results are expressed as the mean ± SEM. and statistically analyzed using one-way analysis of variance (ANOVA followed by a Student-Newman-keuls test for multiple comparisons using Graph Pad Instant statistical program. Values of p < 0.05 were considered to be significant. The ethanolic extract showed the dose-dependent antinociceptive activity in Eddy′s hot plate test, tail immersion test and acetic acid induce writhing test at time intervals 15, 30, 60 and 120 min.

  2. ANTIFERTILITY STUDIES ON ETHANOLIC EXTRACT OF ABRUS PRECATORIUS L ON SWISS MALE ALBINO MICE

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    Sayeed Mohammed Abu et al.

    2012-01-01

    Full Text Available Fertility control is an issue of global and national health concern, many study have been done for the male contraception. The use of medicinal plants in different sorts of disease including fertility problem is widespread throughout the world. Though considerable progress has been made the development of highly effective, acceptable and reversible methods of contraception among females, progress possibilities on males are still slow and limited. With recent progress towards a better understanding of male reproductive physiology there is needed to develop new contraceptive modalities for male. Abrus precatorius is one of the folk medicinal plants widely used as an antifertility agent in varius places of south Asian countries including Chittagong region of Bangladesh. The aim of the present study was to investigate the antifertility activity of abrus precarious seed extract intraperitonially administered in adult swiss male albino mice. The intraperitonial administration of 40, 80 and 80 mg/kg body weight of ethanolic seed extract of Abrus precatorius shown a highly antifertility activity which done for two months. The lower concentrations (40 mg/kg body weight of ethanolic seed extract of Abrus precatorius gave temporarily antifertility activity. But the higher dose (80 mg/kg body weight gave relatively more permanent antifertility activity on swiss albino mice compare with the control.

  3. Biochemical and immunological changes on oral glutamate feeding in male albino rats

    Science.gov (United States)

    Kumar, D.; Bansal, Anju; Thomas, Pauline; Sairam, M.; Sharma, S. K.; Mongia, S. S.; Singh, R.; Selvamurthy, W.

    High altitude stress leads to lipid peroxidation and free radical formation which results in cell membrane damage in organs and tissues, and associated mountain diseases. This paper discusses the changes in biochemical parameters and antibody response on feeding glutamate to male albino Sprague Dawley rats under hypoxic stress. Exposure of rats to simulated hypoxia at 7576 m, for 6 h daily for 5 consecutive days, in an animal decompression chamber at 32+/-2° C resulted in an increase in plasma malondialdehyde level with a concomitant decrease in blood glutathione (reduced) level. Supplementation of glutamate orally at an optimal dose (27 mg/kg body weight) in male albino rats under hypoxia enhanced glutathione level and decreased malondialdehyde concentration significantly. Glutamate feeding improved total plasma protein and glucose levels under hypoxia. The activities of serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) and the urea level remained elevated on glutamate supplementation under hypoxia. Glutamate supplementation increased the humoral response against sheep red blood cells (antibody titre). These results indicate a possible utility of glutamate in the amelioration of hypoxia-induced oxidative stress.

  4. Effect Of Some Aflatoxins On A Lymphatic Organ (Spleen Of Male Albino Rats (Histopathological Study

    Directory of Open Access Journals (Sweden)

    Nahed Ahmed Omar

    2012-07-01

    Full Text Available Background:The present study was planned to compare between two kinds of aflatoxins ( AFB2 and AF Mix on spleen of male albino rats. Fifty young male albino rats ,each weighing 50g, were fed on diets containing aflatoxins at concentration of 1.0 ppm either of AFB2 or AF mix. for 2, 4, 6 weeks followed by a withdrawal period of 2 weeks. Material and Methods:- Rats were randomly divided into 3 groups: the 1st group of 10 rats was fed on the standard diet. The 2nd and the 3rd groups of 20 rats each were maintained on the standard diet plus either AFB2 or AF mix. respectively. Ten animals from the latter 2 groups as withdrawal period. Pieces of spleen were subjected to histological procedures and the obtained sections (6 µm thick were stained with the haematoxylin and eosin, also, mercuric bromophenol blue stain for total protein were used in this study. Results:- Marked histopathological alterations were observed in the studied sections under the influence of AFB2 and AF mix. It was found that AFB2 induced more alterations. The most common changes were lymphocytic degeneration, fatty changes with numerous hemorrhagic areas.The two weeks withdrawal period showed a partial recovery of the developed changes. Conclusion:- This study indicated that AFB2 has a toxic effect on spleen than the equivalent level of AF mix. .Great caution must be followed to prevent the possible contamination of our food with such mycotoxins.

  5. Modelo conceptual de datos difusos de triaje para emergencia hospitalaria representado con FuzzyEER

    Directory of Open Access Journals (Sweden)

    Wuilfredo Rangel

    2010-05-01

    Full Text Available El triaje de emergencia persigue desarrollar el proceso de valorización clínica preliminar para ordenar los pacientes según el nivel de urgencia o gravedad, antes de la atención médica, de forma que en una condición de saturación del servicio o disminución de recursos, los pacientes más graves sean tratados con prioridad. Un proceso de triaje presenta un alto grado de imprecisión o incertidumbre al momento de expresar el estado de salud de un paciente, en consecuencia puede haber dificultad y riesgo en la clasificación de las urgencias. En los servicios de emergencias de loshospitales públicos venezolanos, en especial el servicio de emergencia del Hospital Universitario de Caracas (HUC, seha evidenciado un incremento en el número de casos que se atienden, siendo una constante la saturación del servicio, lo cual imposibilita que los pacientes con prioridad de atención, sean tratados más rápidamente de forma oportuna y eficaz. En este trabajo se propone un modelo conceptual de datos difuso de triaje para el sector salud venezolano basado en el proceso de triaje hospitalario de la Sociedad Venezolana de Medicina de Emergencia y Desastres (SVMED, ya que un modelo de datos que contemple la representación de atributos difusos puede representar de mejor forma los requerimientos del sistema. El modelo propuesto utiliza la notación Entidad Relación con elementos difusos (FuzzyEER para la representación de las entidades y atributos con imprecisión. Dicho modelo será la base de un sistema automatizado de triaje que hará uso del lenguaje de consultas difusas FSQL (Fuzzy SQL.

  6. Modulación de la actividad dopa-decarboxilasa central evaluada mediante PET con 18-F-dopa inducida por la administración crónica de levodopa en macacos con parkinsonismo inducido por MPTP

    OpenAIRE

    M. Riverol; Luquin, M R

    2013-01-01

    La enfermedad de Parkinson (EP) es una entidad frecuentre que afecta fundamentalmente a personas de edad avanzada. Los fármacos más utilizados para el control de los síntomas de esta entidad son la levodopa y los agonistas dopaminérgicos. Diversos estudios de tomografía de emisión de positrones (PET) con 18F-fluorodopa y DAT-scan realizados en pacientes tratados han mostrado, que tras 5 años dde tratamiento, la actividad dopa-descarboxilasa y del transportador de dopamina, fue mayor en los pa...

  7. Cirugía preprotésica e implantológica en pacientes con atrofia maxilar severa

    OpenAIRE

    R. González García; Naval Gias, Luis; Mario F. Muñoz Guerra; Sastre Pérez, Jesús; F.J. Rodríguez Campo

    2005-01-01

    Objetivos. Valoración del éxito en la osteointegración de los implantes dentales en pacientes con atrofia maxilar severa sometidos a cirugía de elevación de seno maxilar y técnica por aposición mediante el uso de injertos de hueso autólogo. Diseño del estudio. Se realiza estudio descriptivo y analítico de 27 pacientes con atrofia maxilar severa y edentulismo parcial o total, durante 4 años de seguimiento. Todos los casos fueron tratados mediante cirugía con utilización de injertos óseos autól...

  8. Neuropatía óptica por radiación: tratamiento combinado con corticoides y anti-VEGF.

    OpenAIRE

    Vanesa Rivero Gutiérrez; Maria Jesus Aparicio Hernandez-Lastras; Marta Suarez Leoz

    2015-01-01

    Caso Clínico: Varón 71 años diabético y fumador, tratado con braquiterapia por melanoma coroideo. A los dos años presenta una neuropatía óptica por radiación y trombosis venosa contralateral. Se trata con corticodes subtenonianos y posteriormente, se interviene de cataratas y se introduce antiangiogénico intravitreo, con buen resultado. Discusión: La neuropatía óptica por radiación  es una vasculopatía progresiva y crónica secundaria a una radiación ionizante supraumbral. Ocurre cuando la dos...

  9. Interaccion de promastigotes de Leishmania donovani con celulas de exudado peritonial de ratones mediante la influencia de la quimotripsina

    Directory of Open Access Journals (Sweden)

    Lucila Arcay

    1986-06-01

    Full Text Available Se hace un estudio de la interacción de promastigotes de Leishmania donovani con células de exudado peritoneal de ratón (c e p mediante la influencia de la quimotripsina. La adhesión de los promastigotes a las c e p fue terminal y marginal, y en observaciones hechas a partir de los 10 minutos de enfrentamiento, esta adhesión fue nula hasta los 30 minutos en el grupo tratado, y sólo a las das horas hubo un pequeño incremento (2.4% con respecto al control. Se observa marcada disminución en todos los parámetro medidos, tales como enlace, penetración, multiplicación intracelular, división de formas flageladas, en el grupo tratado. La quimotripsina favorece la formación de formas intermedias flageladas, heciendose el parásito piriforme y esférico, apareciendo una forma aberrante de extremo anterior cilindrico que semeja a una forma coanoflagelada. Se sospecha que la enzima reduce efectivamente fragmentos proteicos o péptidos, los cuales pueden haber sido tan pequeños como para esconder a otros ligandos relacionados con la adhesión macrófago-parásito.

  10. Las convenciones de comercio, navegación y relaciones internacionales firmadas por Colombia con Estados Unidos y Reino Unido en 1825: al rescate de su memoria, a propósito del TLC

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    Jorge Enrique Elías Caro

    2013-10-01

    Full Text Available Colombia en 1825 firmó con Estados Unidos y el Reino Unido un tratado de libre comercio, de navegación y relaciones internacionales. En este trabajo lo que se persigue es explicar las razones que dieron origen a la firma de estos acuerdos. De igual forma analizar las repercusiones que tuvo para la economía, la política y las condiciones sociales el haber suscrito estos pactos. De la misma manera se hace una analogía de los determinantes que versaban estos tratados con el que actualmente vienen  los gobiernos de Colombia y Estados , para ello se hace una comparación de los articulados y sus contenidos

  11. Estudio de la integración visuomotora en niños con altas capacidades intelectuales

    OpenAIRE

    Gaona Bosque, Sara

    2011-01-01

    A lo largo de los años diversos autores han tratado de demostrar que los niños superdotados -actualmente denominados como niños con “altas capacidades intelectuales”- además de tener una mayor capacidad intelectual destacan también por poseer otras habilidades superiores, como por ejemplo, mayor desarrollo cognitivo, mayor capacidad creativa, niveles superiores de percepción, etc. En el presente estudio tratamos de determinar si también poseen una mejor integración visuomotora. Entendiendo la...

  12. Funcionando con la computadora

    OpenAIRE

    Álvarez, Eduardo; Astiz, Mercedes; Medina, Perla; Montero, Y.; Oliver, María; Rocerau, M. Cristina; Valdez, Guillermo; Vecino, María; Vilanova, Silvia

    2004-01-01

    En este trabajo se presenta la descripción y resultados de la segunda etapa de una experiencia planteada con el objetivo de indagar la manera en que los alumnos determinan e interpretan funciones que explican situaciones problemáticas valiéndose de una nueva forma de trabajo en el aula: la utilización de la computadora como herramienta y un programa asistente matemático. La primera etapa consistió en el desarrollo de un taller optativo con alumnos de entre 14 y 15 años de edad del Colegio Dr....

  13. en pacientes con obesidad

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    Alcia María Alvarado Sánchez

    2005-01-01

    Full Text Available El objetivo de este estudio fue evaluar la eficacia de una intervención psicológica en pacientes con obesidad. Se utilizó un diseño cuasiexperimental con un grupo de estudio y un grupo control. Después de la intervención, se encontró una diferencia significativa en la reducción de peso entre los grupos. Asimismo, hubo un incremento significativo en la autoestima del grupo estudiado.

  14. GARLIC (ALLIUM SATIVUM) EXTRACT AFFECTS THE FREE AMINO ACID LEVEL IN THE GONADS OF FEMALE ALBINO RATS

    OpenAIRE

    Srivastava S; Pathak P. H.

    2012-01-01

    Effect of Allium sativum Linn. (Alliaceae) (Raw Garlic Extract (RGE)) was studied on free amino acids (FAA) level in female albino rats. The garlic extract was tested in three different doses 1ml, 2ml and 4ml/ kg body weight daily as low, medium and high dose respectively for a period of 7, 14, 21 and 28 days. The significant (P

  15. Characterization and comparison of proteomes of albino sea cucumber Apostichopus japonicus (Selenka) by iTRAQ analysis.

    Science.gov (United States)

    Xia, Chang-ge; Zhang, Dijun; Ma, Chengnv; Zhou, Jun; He, Shan; Su, Xiu-rong

    2016-04-01

    Sea cucumber is a commercially important marine organism in China. Of the different colored varieties sold in China, albino sea cucumber has the greatest appeal among consumers. Identification of factors contributing to albinism in sea cucumber is therefore likely to provide a scientific basis for improving the cultivability of these strains. In this study, two-dimensional liquid chromatography-tandem mass spectrometry coupled with isobaric tags for relative and absolute quantification labeling was used for the first time to quantitatively define the proteome of sea cucumbers and reveal proteomic characteristics unique to albino sea cucumbers. A total of 549 proteins were identified and quantified in albino sea cucumber and the functional annotations of 485 proteins have been exhibited based on COG database. Compared with green sea cucumber, 12 proteins were identified as differentially expressed in the intestine and 16 proteins in the body wall of albino sea cucumber. Among them, 5 proteins were up-regulated in the intestine and 8 proteins were down-regulated in body wall. Gene ontology annotations of these differentially expressed proteins consisted mostly of 'biological process'. The large number of differentially expressed proteins identified here should be highly useful in further elucidating the mechanisms underlying albinism in sea cucumber. PMID:26707782

  16. Toxicological evaluation and oral glucose tolerance test of ethanolic leaf extract of Barleria cristata L. in wistar albino rats

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    R. Narmadha

    2013-12-01

    Conclusion: EtBc was revealed the non-toxic nature used for acute toxicity studies and among various doses of this extract, 400 mg/kg brought an effective hypoglycemic activity in wistar albino rats. [Int J Basic Clin Pharmacol 2013; 2(6.000: 742-746

  17. Estudo quantitativo do nervo frênico de rato albino em função do envelhecimento

    OpenAIRE

    Romeu Rodrigues de Souza; Ii-Sei Watanabe; Gerson Chadi; Maria Vilma de Araújo

    1990-01-01

    The phrenic nerve of albino rats was studied for age changes in number of fibres, myelin sheath thickness and axon calibre. Nerves were excised from three young and three aged rats. There is no significant morphological differences between nerves from young and aged rats and no difference with age was found in the number of fibres, myelin sheath thickness and axon calibre.

  18. Acute toxicity of the aqueous-methanolic Moringa oleifera (Lam leaf extract on female Wistar albino rats

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    Mitchel O. Okumu

    2016-10-01

    Conclusions: Based on these results, the LD50 of the AQ-ME MO leaf extract was found to be >2000 mg/kg in female wistar albino rats. Keywords: Moringa oleifera, Aqueous-methanol, Wistar rats, OECD 425, Biochemical assays, Liver [Int J Basic Clin Pharmacol 2016; 5(5.000: 1856-1861

  19. LA PRACTICA CLÍNICA DEL TRABAJO SOCIAL CON LAS PERSONAS MAYORES. BEAVER MARIÓN L MILLER DONJNTERVENCIÓN PRIMARIA, SECUNDARIA, TERCIARIA. PAIDÓS, SEGUNDA EDICIÓN, ESPAÑA 1988,457 PÁGINAS.

    Directory of Open Access Journals (Sweden)

    Yesica Alexandra Rodríguez

    2012-08-01

    Full Text Available El texto brinda elementos clave para el desempeño del trabajo social con personas mayores. Los autores presentan una caracterización detallada de este tipo de población, dan a conocer formas practicas de intervención, tomando como referencia estudios de casos ya tratados y colocando al trabajador social en la posibilidad de observar aquellos papeles que pueda jugar en el momento de acceder esta población.

  20. O-PRECISION: UNA ALTERNATIVA METODOLÓGICA DE TRABAJO CON PERSONAS CON DISCAPACIDAD FÍSICA E INTELECTUAL

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    Victoria Rey Niño

    2015-04-01

    Full Text Available La Clasificación Internacional del Funcionamiento, de la Discapacidad y de la Salud (CIF define la discapacidad como un término genérico que abarca deficiencias, limitaciones de la actividad y restricciones a la participación. En este caso hablamos de personas con discapacidad física e intelectual por parálisis cerebral, lo que significa que su acceso al mundo de la actividad física se encuentra en la mayoría de los casos muy restringido. Pero existe una modalidad de la orientación llamada Orientación de Precisión u O-Trail que, según la Federación Deportiva de Orientación (FEDO, ha sido adaptada para ofrecer a todos, independientemente de su sexo, edad, capacidad o discapacidad física, la oportunidad de participar en igualdad de condiciones en una típica competición de orientación. Como sugiere Arribas y Sánchez (1998: “En la actividad física podemos encontrar recursos y herramientas de intervención adecuadas a cada contexto y etapa de ciclo vital además, a través de su práctica pueden verse satisfechas determinadas necesidades e intereses personales y grupales, que pueden ser tratados desde un planteamiento educativo” . Este proyecto tiene la intención de ir más allá y pretende utilizar la Orientación de precisión como una herramienta para implementar una alternativa metodológica de trabajo a las actividades que se llevan a cabo con un colectivo de personas con discapacidad física e intelectual en la Asociación Cultural y rehabilitadora de Discapacitados Físicos de Palencia, desarrollando y estimulando sus aspectos intelectuales y sociales mediante una disciplina deportiva desconocida para ellos, con la intención de que aumente su motivación por participar.Objetivo: Implementar la O-Precisión como alternativa metodológica de trabajo con personas con discapacidad física e intelectual con el fin de desarrollar sus capacidades cognitivas y aumentar su autoestima.

  1. Shelf life of peaches treated with 1-methylcyclopropene Vida útil de pêssegos tratados com 1-metilciclopropeno

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    Ricardo Alfredo Kluge

    2002-03-01

    Full Text Available Peaches [Prunus persica (L. Bastch] present reduced post-harvest shelf life, partially, due to their high respiratory rate and fast ripening. These processes are related to ethylene production, as well as its action. Peaches, cv. Aurora-1, were picked at two different ripening stages (mature green and ripe and treated with 1-methylcyclopropene (1-MCP, the ethylene's competitive antagonist, at concentrations of 0, 100, 300 and 900 nL L-1 for 12 hours at 25ºC. After treatment, the fruits were stored at room temperature (25ºC for six days. Fruits treated with 1-MCP presented better firmness and less ground color loss than non-treated fruits. The 1-MCP antagonist reduced the development of fruit rot at the mature green stage, but not at the ripe one. The 1-MCP shows commercial application potential in the treatment of peaches in order to delay the ripening process and increase their shelf life.Pêssegos [Prunus persica (L. Bastch] apresentam reduzida vida útil pós-colheita devido, em parte, a sua alta taxa respiratória e amadurecimento rápido. Estes processos estão relacionados com a produção e a ação do etileno. Pêssegos cv. Aurora-1 foram colhidos em dois estádios de maturação (verde e maduro e tratados com o antagonista competitivo do etileno 1-metilciclopropeno (1-MCP nas concentrações de 0, 100, 300 e 900 nL L-1, durante 12 horas a 25ºC. Após o tratamentos os frutos foram armazenados em condições ambientais (25ºC durante seis dias. Os frutos tratados com 1-MCP apresentaram maior firmeza de polpa e menor perda de coloração de fundo se comparado com os frutos não tratados. O 1-MCP reduziu o desenvolvimento de podridões em frutos do estádio verde, mas não em frutos maduros. O 1-MCP apresenta potencial de aplicação comercial em pêssegos, visando retardar o amadurecimento e aumentar sua vida útil de prateleira.

  2. Tratamiento endovascular de una fuga paraprotésica mitral con dispositivo Amplatzer®

    Directory of Open Access Journals (Sweden)

    Alberto Sciegata

    2012-10-01

    Full Text Available El leak o fuga paraprotésica mitral se presenta entre el 5 y el 17% de los pacientes tratados con cirugía de reemplazo valvular. En general, los defectos son únicos, la mayoría se encuentran localizados en la región postero-medial del anillo valvular y solo la tercera parte produce reflujo de grado grave. El cierre percutáneo por vía endovascular es una alternativa terapéutica válida en pacientes con elevado riesgo para re-operación. La estrategia de abordaje depende de la localización, tamaño, morfología y relaciones adyacentes del o los defectos. El procedimiento debe ser realizado por profesionales con experiencia en el tratamiento de cardiopatías estructurales y en el manejo de estos dispositivos de cierre, y se considera imprescindible la utilización de un ecocardiograma transesofágico tridimensional. Se presenta el caso de un paciente con una fuga paraprotésica valvular mitral que fue cerrada con un dispositivo Amplatzer ® introducido en forma percutánea desde la vena femoral.

  3. Impacto del Tratamiento con Teriparatida en la Calidad de Vida de las Personas con Osteoporosis

    Directory of Open Access Journals (Sweden)

    Marta Osca Guadalajara

    2015-01-01

    Full Text Available La pérdida ósea en pacientes osteoporóticos, conlleva riesgo de fracturas, dolor óseo vertebral y disminución de la calidad de vida. El objetivo de este trabajo fue analizar el efecto de la teriparatida (TPTD en pacientes osteoporóticos y con dolor vertebral. Métodos: Estudio observacional longitudinal prospectivo, entre abril de 2006 y febrero de 2014, en los 77 pacientes tratados con TPTD en la Unidad del Dolor del Hospital de Teruel. La duración del tratamiento fue de 18 o 24 meses. Se utilizó la Escala Visual Analógica (EVA para la medición del dolor y el cuestionario europeo de calidad de vida (EuroQol-5D para obtener la tarifa social (TS, antes y después el tratamiento. Se realizó un análisis descriptivo, de regresión lineal y logística. Resultados: Se observó una mejoría del dolor (80% y de la calidad de vida (65 %. Se mejoró la EVA media (5,42 a 3,47 puntos y el EuroQol-5D (0,36 a 0,58 puntos. La regresión indicó una mejora de la EVA en 0,441 puntos por cada punto de EVA inicial, y de la TS en 0,0528 puntos por cada 0,1 puntos de TS inicial. La probabilidad de mejorar la EVA en 3 puntos (OR=2,021, fue mayor que de mejorar 2 puntos (OR=1,695. Conclusiones: La TPTD en pacientes osteoporóticos reduce el dolor óseo y mejora la calidad de vida. Su efecto es mayor en pacientes con peor estado de salud inicial, pudiendo ser utilizado como criterio para las decisiones terapéuticas y de gestión clínica.

  4. CGP 35348, GABAB Receptor Antagonist, Has a Potential to Improve Neuromuscular Coordination and Spatial Learning in Albino Mouse following Neonatal Brain Damage

    Directory of Open Access Journals (Sweden)

    Q. Gillani

    2014-01-01

    Full Text Available To study the effect of CGP 35348 on learning and memory in albino mice following hypoxia ischemia insult, 10 days old albino mice were subjected to right common carotid artery ligation followed by 8% hypoxia for 25 minutes. Following brain damage, mice were fed on normal rodent diet till they were 13 week old. At this time point, mice were divided into two groups. Group 1 received saline and group 2 intrapertoneally CGP 35348 (1 mg/mL solvent/Kg body weight for 12 days. A battery of tests used to assess long term neurofunction (Morris water maze, Rota rod and open field along with brain infarct measurement. Overall CGP 35348 has improved the motor function in male and female albino mice but effects were more pronounced in female albino mice. In open field, CGP 35348 treated female albino mice had demonstrated poor exploratory behavior. During Morris water maze test, gender specific effects were observed as CGP 35348 had improved spatial learning and memory and swimming speed in male albino mice but had no effect in female albino mice following hypoxia ischemia encephalopathy (HIE. We concluded that GABAB receptor antagonists CGP 35348 can be used to improve gender based spatial memory.

  5. Retención y Penetración en Estacones de Eucalyptus Saligna. Sometidos a Tratamiento con CuSO4 y Sal CCC, en Baño Caliente y frio y Vacio-Presión

    Directory of Open Access Journals (Sweden)

    Escobar C. Oscar

    1987-09-01

    Full Text Available Este trabajo describe y da los resultados obtenidos con el pretratamiento de estacones de Eucalyptus saligna a tres soluciones de CUS04 y su posterior tratamiento con sales CCA (OSMOSE K-33. El sulfato de cobre se aplicó por el método de baño caliente y frío, seguido por el proceso de difusión durante una semana; para los anteriores tratamientos se usó madera verde o parcialmente seca al aire; las sales CCA se aplicaron a madera seca por el método de vacío-presión. Una de las razones para llevar a cabo este refuerzo de las sales CCA, es haber encontrado postes de eucalipto severamente atacados por hongos, en especial con pudrición blanda. Los estacones fueron tratados inicialmente con soluciones de sulfato de cobre a 1 %, 2% y 3% de concentración; luego los estacones fueron tratados con una solución de sal CCA al 2.5% de concentración por vacío-presión. Se usaron 40 estacones distribuídos en 4 grupos de 10: tres (3 grupos fueron usados para el tratamiento con las soluciones de CUS04 y solución de CCA; el grupo restante fue tratado con la sal CCA únicamente, el cual fue usado como grupo testigo para fines de comparación en los ensayos de campo (cementerios.

  6. COMPARISON OF ANTIDEPRESSANT ACTIVITY OF LOSARTAN WITH IMIPRAMINE IN ALBINO MICE

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    Choppadandi

    2016-06-01

    Full Text Available OBJECTIVES Comparison of antidepressant activity of Losartan with Imipramine in albino mice. BACKGROUND Of all the afflictions that trouble the soul, depression is the commonest characterised by a state of low mood and aversion to activity that can affect a person's thoughts, behaviour, feelings and physical well-being. Similarly, hypertension is another condition which has emerged as a major public health problem in India and many other developing countries. There is compulsion that 35% of the population has to use the antihypertensives and antidepressants simultaneously for a long period of time to maintain their health. The present work is aimed at comparing antidepressant activity of losartan with imipramine which acts by raising brain BDNF (Brain derived neurotrophic factor levels so that a single agent can be used for both the conditions avoiding multiple medications. METHOD 18 Albino mice were taken, divided into 6 mice in each group and subjected to Forced swim test. All the drugs were administered orally. Drugs were administered and time of onset of immobility is measured 60 min. after the drug administration along with total duration of immobility. Animals are exposed to pretest of 15 min., 24 hrs. prior to the 6 min. swim test. Each animal is considered immobile when it ceased to struggle and swim and remained floating in the water, only moving to keep its head above water. Control group received distilled water (10 mL/kg. Standard group received Imipramine (5 mg/kg and test group was treated with Losartan (3 mg/kg. The Forced swim test for each mouse was video captured which was later analysed to count the time of onset of immobility and total duration of immobility. RESULTS Data was analysed using Analysis of Variance (ANOVA. Losartan showed significant antidepressant activity indicated by significant delay (P<0.05 in the time of onset of immobility and significant reduction (P<0.05 in the total duration of immobility compared to

  7. Tratamiento con inmunoterapia específica en niños con Rinitis Alérgica y/o Asma Bronquial. Área Norte. 2005 - 2007.

    Directory of Open Access Journals (Sweden)

    Matilde Iraida Morera Franco

    2007-10-01

    Full Text Available Se realizó un estudio descriptivo longitudinal durante el período Enero 2005_ Enero 2007 en el Policlínico Norte del municipio Sancti Spíritus. El universo estuvo constituido por el total de niños con edades de 2_15 años con enfermedades alérgicas, a los que se realizó pruebas de alergia e indicó tratamiento con inmunoterapia específica por vía subcutánea, la muestra estuvo formada por 75 pacientes con asma bronquial, rinitis alérgica y/o ambas enfermedades, con el objetivo de determinar el comportamiento del tratamiento con inmunoterapia específica se aplicó el método porcentual para el análisis de resultados, donde el grupo etáreo que predominó fue de 2 _5 años, más del 65 % de los pacientes tratados refirieron mejoría de los síntomas las causas más frecuentes de abandono de tratamiento fue la aparición de infecciones intercurrentes, no ocurrió reacción anafiláctica en ninguno de los casos estudiados, el tratamiento con inmunoterapia puede reducir el uso de otros tratamientos asociados como Intal, antihistamínicos, broncodilatadores y esteroides.

  8. Los derechos fundamentales y su incorporación en los tratados de Libre Comercio

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    Carlos Valega Puello

    2004-01-01

    Full Text Available En la última década del siglo XX, noobstanteasistira un proceso de ace/eración de las economías mundiales, caracterizadas por la globalización y el neoliberalismo, han sido importantes los esfuerzos encaminados a proteger los derechos de los trabajadores, especialmente los relacionados con la libertad de asociación y libertad sindical y derecho de negociación colectiva, la eliminación de toda forma de trabajo forzoso y obligatorio, la abolición del trabajo infantil y la eliminación de toda discriminación en materia de empleo y ocupación. Tales esfuerzos ratifican la necesidad de incorporar la dimensión social tanto en los acuerdos comerciales como en los procesos de integración regional.

  9. Colombia & the New Global Economy: Implications of Tratado de Libre Comercio for Colombian Industry, Engineers and Engineering Educators

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    Bopaya Bidanda

    2006-11-01

    Full Text Available The landscape of the world economy has changed significantly over the last twenty five years. The inter-connectedness of national economies, the rapid ascent of the BRIC countries (Brazil, Russia, India, China in the global engineering environment and the pro-active role of organizations such as the World Trade Organization, regional alliances such as the EU, and Mercosur are factors that have synergized this movement towards a new order. The completion of the Tratado de Libre Comercio (TLC agreement is a major milestone for the Colombian economy. These developments have serious and opportunistic implications for organizations, engineers, and engineering educators. We focus here on the drivers and consequences for engineering practitioners and educators. Corporate strategies, along with the need for engineering curriculum reform to ensure that Colombian engineers will effectively compete in the global marketplace, are detailed.

  10. Un tratado de nobleza de un regidor coruñés de principios del siglo XVII

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    García Hurtado, Manuel Reyes

    2006-12-01

    Full Text Available We present the publication and annotated study of a treatise on nobility written about 1621 by Juan Melio de Sande, an councillor from A Coruña. We emphasise the characteristics common to these kinds of texts and we try to clarify the author’s motives. In his format, argument, and authorities referred to, he could only follow the most reputable specialists on the subject of genealogy at that time.

    Presentamos la publicación y el estudio anotado de un tratado de nobleza redactado hacia 1621 por el regidor de A Coruña Juan Melio de Sande. Hacemos hincapié en las características comunes a este tipo de textos e intentamos dilucidar las motivaciones de su autor. En su formato, argumentación y autoridades empleadas no hace sino seguir a los más reputados especialistas en materia nobiliaria de su tiempo.

  11. Effect of salvia Egyptiaca extract on cholinergic system in adult male albino rats

    International Nuclear Information System (INIS)

    The daily oral administrations of Salvia aegyptiaca extract, equivalent to 2 g/kg body weight for 4 weeks, caused significant decrease in acetylcholine esterase activity in whole blood and in all tested brain areas (cerebellum, pons + medulla oblongata, striatum, cerebral cortex, hypothalamus, midbrain and hippocampus) of male albino rat nearly all over the experimental period. Treatment with Salvia aegyptiaca extract also resulted in significant increase in acetylcholine content in the cerebral cortex and hippocampus' nearly throughout the whole experimental period. It could be concluded from the present results that the extract of Salvia aegyptiaca caused an increase in acetylcholine content and this increase may be due to the decrease in the activity of acetylcholine esterase enzyme which play an important role in the treatment of Alzheimer's disease

  12. Harmful effect of protein difficiency on lipids, glucose, insulin and estradiol levels in female albino rats

    International Nuclear Information System (INIS)

    The present study was undertaken to investigate the harmful effect of protein deficient diet on some biochemical activities in serum of female rats. Protein malnutrition is a well known socioeconomic problem in different parts of the world. Many studies were investigated on the biological parameters following protein malnutrition in human and experimental animals. Forty albino female rats were divided into 3 groups. The first group (10 rats) fed 18% protein diet and served as normal control and the other two groups, each contains 15 rats, fed 5% protein for 21 and 45 days, respectively, and served as malnourished groups. The results showed significant decrease in total body weight, serum glucose, insulin and estradiol levels in the third group as well as decrease in the total cholesterol, HDL-cholesterol, LDL-cholesterol and VLDL-cholesterol and triglycerides concentrations that compared to normal control rats

  13. Cyathula prostrata:A potent source of anticancer agent against daltons ascites in Swiss albino mice

    Institute of Scientific and Technical Information of China (English)

    Priya K; Krishnakumari S; Vijayakumar M

    2013-01-01

    Objective:To evaluate the anticancer activity of the methanolic extract of Cyathula prostrata inEhrlich ascites carcinoma(EAC)-bearing mice with methotrexate as positive control in the advanced stage of tumorigenesis.Methods:EAC was induced in swiss albino mice by injecting 106 cell/mL of tumor cell suspension intraperitoneal.The methanolic extract of Cyathula prostrata effect on the tumor cell viability,DNA fragmentation andMTT assay were carried out.Results:Methanolic extract attenuated percentage increased in the cell survival time when compared to control group.However, the effect was less than that of methotrexat.Methotrexat and the extracts reversed the tumor-induced alterations inDNA fragmentation andMTT assay.Conclusions:The present study suggests that the methanol extract ofCyathula prostratahas significant anticancer activity and that is comparableto that of methotrexate.

  14. Sub-chronic toxicity and heavy metal toxicity study on Kappaphycus alvarezii in albino rats

    Institute of Scientific and Technical Information of China (English)

    AbiramiRG; KowsalyaS

    2012-01-01

    Objective: This study aimed to evaluate the toxicity of Kappaphycus alvarezii methanolic extracts in albino rats. Methods: Sub-chronic toxicity was tested with a single dose of intraperitonal administration of the extract as per the OECD guidelines in the experimental group rats and the control group rats was fed with standard diet and water ad libitum. Mortality, behaviour changes, clinical signs and symptoms, food intake, body weight and any abnormalities of the visceral organs were observed. Results: The results revealed that the algal extract resulted in neither mortality nor any abnormalities. The Most of the serum biochemical parameters and hematological values were similar in control and experimental groups, histopathological examination of the vital organs like liver, kidney, spleen, brain and heart revealed no obvious abnormality in the control group and Kappaphycus alvarezii treated group. Conclusion: It may be concluded that Kappaphycus alvarezii rich in nutrient and nutraceutial potentials and also safety food for human consumption.

  15. Effect of Escherichia coli infection on the histopathology of albino mice visceral organs

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    Abin Biswas

    2010-03-01

    Full Text Available Histopathology is very essential in assessing the nature and state of the tissues. It is used widely to examine the visceral organs in various diseases, infections and disorders. It provides the required insight and details about the possible malfunctioning of the disease or infection. Albino mice were taken and test group was infected withEscherichia coli. The control group was not infected with any linical pathogen. The histopathological examination was carried out to determine the effect of infection in the test group. Liver, spleen and kidney were the visceral organs which were used for the study. The size, shape and other morphological characteristics had markeddifference in case of infected mice when compared with control group mice. Histopathological analysis can be further extended in the case of other clinical pathogenic infections which could lead to nteresting results.

  16. Haematological And Biochemical Changes Induced By Amaranth Impact On Male Albino Rats

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    Shadia Ali Radwan; Ahmed Riad El-Sayed; Mohammed Salah Al-Shinnawy

    2010-09-01

    Full Text Available The present investigation was performed to study the effect of daily administration (interperitoneal injection of synthetic coloring agent amaranth at dose 50 mg /kg b.w. /day for two periods (7 and 21 days, using male albino rats. The effects of amaranth on growth, haematological and some biochemical parameters were examined throughout the study. The results revealed that amaranth treatment cause a marked change in treated groups when compared with control. They showed a significant decrease in percentage of body weight change, RBCs count, Hb concentration and HCT value, while, they recorded a significant increase in WBCs, serum activity of AST and ALP, in addition to serum urea and creatinine levels in treated rats. But ALT and bilirubin showed insignificant changes throughout the experiment.

  17. Spermatotoxic, cytotoxic and genotoxic evaluation of aqueous extract of Ocimum gratissimum in albino mice

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    Akeem Akinboro

    2013-11-01

    Full Text Available Ocimum gratissimum (Lamiaceae is an alternative medicine as well as food condiment in African and Asian countries. Information on its safe consumption is important considering its wide utilization. The potential effects of aqueous extract of this plant on cell division, chromosome structure and sperm morphology in mice were investigated. The Inductions of chromosomal aberrations and abnormal sperm cells were not dose dependent. However, these were and sperm morphology tests, respectively. Aberrant sperm cell in form of tail folded over head was observed most. These observations suggest possible mutagenic activity of the aqueous extract of O. gratissimum in albino mice. Key words: Ocimum gratissimum, chromosome, mitotic index, sperm cells, aqueous extract  

  18. Evaluation of radioprotective effects of Rajgira (Amaranthus paniculatus) Extract in Swiss albino mice

    International Nuclear Information System (INIS)

    The radioprotective efficacy of aqueous extract of Rajgira (Amaranthus paniculatus) leaves against whole body gamma radiation was studied in Swiss albino mice. The oral administration of Rajgira extract at 800 mg/kg body weight/day for 15 consecutive days before whole body exposure to radiation was found to be effective with the LD50/30 values of 6.33 and 8.62 Gy for irradiation alone and Rajgira+irradiation group, respectively, giving a dose reduction factor of 1.36. This effect of Rajgira accompanied the increased endogenous spleen colonies and the spleen weight without any side effect or toxicity, as well as the modulation of the radiation-induced decrease of reduced glutathione and the radiation-induced increase in lipid peroxidation assessed in the liver and the blood. (author)

  19. Effects of lithium carbonate on the microanatomy of thyroid gland of albino rats

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    Nasseer Ahmad Shah

    2014-02-01

    Results: Microscopic changes in thyroid gland of albino rats were evident after 8 weeks of drug administration which include marked pleomorphism, shrinkage in size of thyroid follicles, excess of colloid and marked vacuolations in acini. At 12th week of study, follicles were found both macro and micro follicular, with variable lining epithelium and hyperchromatic nuclei. Lining epithelium of some follicles was disrupted. The stroma was infiltrated with lymphocytes and eosinophils and there were some interfollicular hemorrhages. Conclusions: Lithium given over prolonged period will cause macro and micro follicular goiter with hyperplastic epithelium and hyper chromatic nuclei, hyperplasia of stroma with increased vascularity, sometimes hemorrhages and finally may lead to thyroiditis like picture. So, it is advised that patients on lithium therapy should be periodically evaluated for thyroid dysfunction. [Int J Res Med Sci 2014; 2(1.000: 279-284

  20. HYPOGLYCEMIC ACTIVITY OF PASSIFLORA EDULIS SIMS LEAF EXTRACT IN WISTAR ALBINO RATS

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    Kanakasabapathi Devaki

    2011-09-01

    Full Text Available The traditional medicinal plant P.edulis was tested for its hypoglycemic effect in Wistar albino rats. The oral glucose tolerance test was performed in overnight fasted normal as well as in alloxan induced diabetic rats (150 mg/kg, of alloxan, i.p. with the administration of 100,200,300,400 mg/kg of b.wt of P.edulis. The blood sample withdrawn at 0, 60, 120, 180 min of glucose administration from the retro orbital sinus by capillary puncture indicated the hypoglycemic nature of the P.edulis leaf extract and identified the most effective dose as 200mg/kg b.wt.

  1. Effect of Aqueous Flower Extract of Catharanthus roseus on Alloxan Induced Diabetes in Male Albino Rats

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    A. Natarajan

    2012-04-01

    Full Text Available Catharanthus roseus is widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus. The present study was carried out to investigate the antidiabetic and hyperlipidemic potential of Catharanthus roseus on alloxan induced diabetes in male albino rats. Oral administration of aqueous extract of Catharanthus roseus at a dose of 250 mg, 350 mg, and 450 mg/kg body weight for 30 days to diabetic rats resulted in significant reduction in blood glucose, reduction in lipid profile and also prevented a decrease in body weight. Histological observation demonstrated significant fatty changes and inflammatory cell infiltrates in pancreas of diabetic rats. But, supplementation with Catharanthus roseus to diabetic rats significantly reduced the fatty changes and inflammatory cell infiltrates.

  2. Inheritance of a new albino mutation in Brazilian free-range black chickens

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    W Jorge

    2008-09-01

    Full Text Available A genetically recessive albino mutation, which inhibits pigment development in the eyes, skin, and feathers of domestic chickens from Brazil, is described. This mutation appeared in a flock of completely black chickens of a private breeder. There are no information on the origin, breed, or specific line of the birds. Pigment inhibition is apparently complete in the feathers and eyes. Bird sight is very impaired, but no histological examination was carried out. Ratios obtained in F2 and backcrossed birds indicate that a single autosomal recessive gene is responsible for the condition. The data suggest that the absence of melanin in the eyes, skin, and feathers (symbol cc is a mutation of the pigmented C wild gene.

  3. Histopathological changes in Wistar albino rats exposed to aqueous extract of unripe Carica papaya

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    Taofeeq Oduola

    2010-05-01

    Full Text Available Background: Exposure of animals to xenobiotics may or may not trigger adverse response at cellular levels. Aqueous extract of unripe Carica papaya is consumed by sickle cell patients as antisickling agent in Western Nigeria. Aim: This study was undertaken to investigate the effects of Carica papaya on certain organs in Wister albino rats exposed to aqueous extract of unripe Carica papaya. Materials and Methods: Different doses of aqueous extract of unripe Carica papaya were administered orally daily for 42 days to six groups of rats. At the end of exposure, the animals were sacrificed and tissue sections were prepared from livers, kidneys, hearts and small intestines using standard techniques. Results: Histopathological results showed that no pathological changes were observed in tissue sections of experimental animals when compared with tissue sections of the same organs in control animals. Conclusion: No pathological changes were elicited in the organs of rats exposed to aqueous extract of unripe Carica papaya.

  4. HYPOGLYCEMIC EFFECT OF ACETONE EXTRACT OF TERMINALIA ARJUNA ROXB. BARK ON TYPE-2 DIABETIC ALBINO RATS

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    SHAMSHUN NEHAR

    2013-01-01

    Full Text Available In the present study, hypoglycemic effects of Terminalia arjuna bark extract were seen in high fructose (21%followed by streptozotocin (40mg/kg BW induced type-2 diabetic male albino rats. In vivo study showedprotective effect of T. arjuna bark acetone extract of towards blood glucose, serum urea, serum createnine, SGOT,SGPT, oral glucose tolerance (OGTT, urine sugar and urine ketone bodies in diabetic rats. Feeding 500 mg/kgBW arjuna bark extract to rats showed better effect for blood and urine parameters as compared to rats fed with250 mg/kg BW arjuna bark extract. The effect of feeding 500 mg/kg BW arjuna bark extract was found to bealmost equal to that of with glimepiride fed diabetic rats. The result indicated that Terminalia arjuna bark acetoneextract of have antidiabetogenic and possess hypoglycemic effects in type-2 diabetic rats.

  5. Histopathological changes in Wistar albino rats exposed to aqueous extract of unripe Carica papaya

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    Taofeeq Oduola

    2010-01-01

    Full Text Available Background : Exposure of animals to xenobiotics may or may not trigger adverse response at cellular levels. Aqueous extract of unripe Carica papaya is consumed by sickle cell patients as antisickling agent in Western Nigeria. Aim : This study was undertaken to investigate the effects of Carica papaya on certain organs in Wister albino rats exposed to aqueous extract of unripe Carica papaya. Materials and Methods : Different doses of aqueous extract of unripe Carica papaya were administered orally daily for 42 days to six groups of rats. At the end of exposure, the animals were sacrificed and tissue sections were prepared from livers, kidneys, hearts and small intestines using standard techniques. Results : Histopathological results showed that no pathological changes were observed in tissue sections of experimental animals when compared with tissue sections of the same organs in control animals. Conclusion : No pathological changes were elicited in the organs of rats exposed to aqueous extract of unripe Carica papaya.

  6. Estabilidad de emulsiones preparadas con proteínas de sueros de soja

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    Jorge Wagner

    2011-12-01

    Full Text Available Por precipitación con acetona en frio, se obtuvieron muestras de proteínas aisladas de dos sueros de soja, el suero SS proveniente de la obtención de aislados de soja y el suero de tofu ST. A partir del SS y del mismo suero previamente liofilizado y calentado (SSLC se obtuvieron las proteínas denominadas PSS y PSSLC, respectivamente; a partir de ST se preparó la muestra PST. El objetivo del trabajo fue analizar la estabilidad de emulsiones o/w preparadas con las proteínas de sueros de soja en forma comparativa con un aislado de soja nativo (ASN. Las emulsiones se prepararon por homogeneización de dispersiones proteicas (0,1–1,0 % p/v en buffer fosfato 10 mM pH 7 y aceite de girasol (Φmásico=0,33, empleando un Ultraturrax T-25. La estabilidad fue evaluada por medida del aceite separado, distribución de tamaño de partículas (por difracción láser y los grados de cremado y coalescencia evaluados a través de perfiles de BackScattering. Se observó que en todas las concentraciones ensayadas las emulsiones preparadas con proteínas aisladas (por precipitación con acetona en frío de suero de tofu tratado térmicamente (PST tenían una estabilidad comparable a la de emulsiones preparadas con ASN. Se halló una estabilidad menor en emulsiones con proteínas nativas de suero de soja (PSS obtenido en laboratorio no tratado térmicamente. Las proteínas obtenidas de este suero liofilizado y calentado (PSSLC exhibieron una mejor capacidad emulsionante. Los resultados mostraron que las proteínas de sueros de soja presentan buenas propiedades emulsionantes y estabilizantes dependientes del grado de desnaturalización y glicosilación alcanzado.

  7. Nigella sativa oil Ameliorates ionizing Radiation induced cellular injury in Male Albino Rats

    International Nuclear Information System (INIS)

    Nigella sativa (NS), commonly known as black seed, is a plant spices in which thymoquinone is the main active ingredient isolated from the black seeds. The seeds of Nigella sativa are used in herbal medicine all over the world for the treatment and prevention of a number of diseases. The aim of this study was focused on investigating the possible protective effect of NS against gamma radiation induced nephrotoxicity and inflammatory changes in male albino rats. Twenty four albino rats were divided into four equal groups as follows: control group, irradiated group (animals subjected to whole body gamma irradiation at a dose of 6 Gy), treated group (rats treated with 0.2 ml/kg, i.p., NS oil for 4 weeks), and treated irradiated group (animals treated with 0.2 mL/kg, i.p., NS oil for 4 weeks then exposed to whole body gamma irradiation at a dose of 6 Gy). The obtained results revealed that the administration of Nigella sativa oil to irradiated rats significantly ameliorated the changes induced in kidney antioxidant system; catalase and glutathione peroxidase activities as well as reduced glutathione concentration. Also, NS oil restored the kidney function indices (urea and creatinine) near normal level when compared with their equivalent values in irradiated rats. In addition, the changes in serum tumor necrosis factor alpha (TNF-α), Interleukin-1β (IL-1β) and Interleukin-6 (IL-6) activities were markedly improved compared to the corresponding values of irradiated group. The histopathological results showed distinctive pattern of ischemic renal injury in irradiated group, while in treated- irradiated group the renal tissues showed relatively well-preserved architecture with or without focal degeneration. In conclusion, NS acts in the kidney as a potent scavenger of free radicals to prevent or ameliorates the toxic effects of gamma irradiation as shown in the biochemical and histopathological study and also NS oil might provide substantial protection against

  8. Pharmacokinetics of ofloxacin in serum and vitreous humor of albino and pigmented rabbits.

    Science.gov (United States)

    Perkins, R J; Liu, W; Drusano, G; Madu, A; Mayers, M; Madu, C; Miller, M H

    1995-07-01

    The purpose of this study was to evaluate the pharmacokinetics of ofloxacin in serum and vitreous humor samples from albino and pigmented rabbits by using a recently described animal model which permits robust estimation of parameter values. The drug was administered to rabbits intravenously, multiple vitreous humor and serum samples were taken from each rabbit, and the vitreous humor and serum samples were assayed by high-pressure liquid chromatography. The pharmacokinetic parameters were determined with RSTRIP, an iterative, nonlinear, weighted, least-squares regression program. Eight New Zealand White rabbits and eight Dutch Belted rabbits (split into single-dose and multiple-dose groups) were investigated in this study. The value of penetration into the vitreous humor of albino rabbits (n = 6) was 32.6% +/- 2.12%, with terminal-elimination half-life values of 3.21 and 2.39 h, respectively, for vitreous humor and serum. In pigmented rabbits after a single dose (n = 3) and with a steady-state concentration of drug in serum (n = 4), penetration values were similar, at 30.4% +/- 2.98% and 30.0% +/- 4.12%, respectively (P > 0.10). Following a single dose of ofloxacin, pigmented animals had elimination half-life values from serum and vitreous humor of 2.64 and 4.32 h, respectively. After steady state was achieved, half-life values for serum and vitreous humor were 3.12 and 6.05 h, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

  9. ANALGESIC ACTIVITY OF AQUEOUS EXTRACT OF CURCUMA AMADA (MANGO - GINGER IN MALE ALBINO WISTAR RATS

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    Kumari Bai

    2015-09-01

    Full Text Available BACKGROUND: Mango ginger ( Curcuma amada Roxb. has morphological resemblance with ginger, but imparts mango flavour. According to Ayurveda and Unani medicinal systems , the biological activities include antioxidant, antibacterial, antifungal, anti - inflammatory, antiallergic, CNS depressant and analgesic activity. Hence curcuma amada aqueous extract for analgesic activity was evaluated in pain animal models. Pain is a most common complaint of many medical conditions, and pain control is one of t he most important therapeutic priorities. Curcuma Amada suppresses the inflammatory mediators associated with pain. However there is no scientific data suggestive of its analgesic activity. Hence this study was carried out to evaluate its role in central a nd peripheral models of pain. OBJECTIVE: To Evaluate rhizomes of Curcuma Amada for analgesic activity in male albino wistar rats . MATERIALS AND METHODS: Albino rats, the proven models for analgesic studies. They were obtained from the animal house of DR.B. R. Ambedkar Medical College. Animals were maintained as per CPCSEA guidelines . The aqueous extract of curcuma amada was used.4x2 groups of 6 Rats were used to ensure that results obtained were statistically significant using ANOVA test. Analgesic activity was assessed with the help of following screening methods . Acetic Acid Writhing Method using Acetic Acid . Tail Flick Method using the Analgesiometer . Tail Immersion Method using Hot Water (55 0 C . Hot Plate method using Hot Plate . RESULT S: Aqueous extract of curcuma amada significantly suppressed the 1% acetic acid induced writhing response in rats when compared to control group (Gum acacia. In Tail flick test and Hot plate test Curcuma Amada increases the latency period of pain (reaction time. In Tail im mersion test the test drug significantly (P < 0.001 reduces pain at 30 min when compared to control group at 60 min of oral administration. CONCLUSION : The present findings indicate that

  10. ANTIDIABETIC AND HYPOLIPIDEMIC ACTIVITY OF GYMNEMA SYLVESTRE IN DEXAMETHASONE INDUCED INSULIN RESISTANCE IN ALBINO RATS

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    Hemanth Kumar V, Nagendra Nayak IM , Shobha V Huilgol, Saeed M Yendigeri , Narendar K

    2015-07-01

    Full Text Available Background: Gymnema sylvestre plant was widely used for medicinal purpose. The plant leaves were traditionally used to treat diabetes. Aim: To determine the antidiabetic and hypolipidemic activity of Gymnema sylvestre in dexamethasone induced insulin resistance in Albino rats. Objectives: The present study was undertaken to evaluate antidiabetic and hypolipidemic activity of Gymnema sylvestre leaf aqueous extract against dexamethasone induced insulin resistance in Albino rats. Materials and Methods: Animals were divided into five groups. Normal control and diabetic control group received gum acacia (2% orally for 12days, and normal saline (i.p., dexamethasone (8mg/kg/i.p. from day 7- day12 respectively. Two test groups (Gymnema sylvestre leaf aqueous extract 2 and 4gm/kg/p.o./12days and standard control received metformin (2gm/kg/p.o./12 days. The two test groups, standard control group received dexamethasone (8mg/kg/i.p from day 7- day 12 respectively. The antidiabetic and hypolipidemic activity was estimated by measuring serum glucose, insulin, lipid levels and histopathological evaluation of liver tissue. Results were analyzed by using one way ANOVA followed by Scheffe’s multiple comparison test. Results: Treatment with aqueous extract of Gymnema sylvestre (2 and 4gm/kg/p.o significantly (p<0.01 altered the elevated glucose, lipid, insulin levels and also improved the histopathology of liver in dexamethasone induced insulin resistance rats. Conclusion: Treatment with aqueous extract of Gymnema sylvestre improved the altered glucose, insulin and lipid profile in insulin resistance rats.

  11. Effect of sorafenib on sperm count and sperm motility in male Swiss albino mice

    Science.gov (United States)

    Shetty, Surekha Devadasa; Bairy, Laxminarayana Kurady

    2015-01-01

    The issue of male germ line mutagenesis and the effects on developmental defects in the next generation has become increasingly high profile over recent years. Mutagenic substance affects germinal cells in the testis. Since the cells are undergoing different phases of cell division and maturation, it is an ideal system to study the effect of chemotherapeutic agents. There are lacunae in the literature on the effect of sorafenib on gonadal function. With background, a study was planned to evaluate the effects of sorafenib on sperm count and sperm motility in male Swiss albino mice. Male Swiss albino mice were used for the study. The animals were segregated into control, positive control (PC) and three treatment groups. PC received oral imatinib (100 mg/kg body weight) and treatment groups received 25, 50, and 100 mg/kg body weight of sorafenib orally for 7 consecutive days at intervals of 24 h between two administrations. The control group remained in the home cage for an equal duration of time to match their corresponding treatment groups. The animals were sacrificed at the end of 1st, 2nd, 4th, 5th, 7th, and 10th weeks after the last exposure to drug, respectively. Sperm suspensions were prepared and introduced into a counting chamber. Total sperm count and motility were recorded. There was a significant decrease in sperm count and sperm motility by sorafenib which was comparable with the effect of PC imatinib. Sorafenib adversely affects sperm count and sperm motility which are reversible after discontinuation of treatment. PMID:26605157

  12. EVALUATION OF ANXIOLYTIC POTENTIAL OF ETHANOLIC EXTRACT HYPERICUM HOOKERIANUM IN STRESS INDUCED SWISS ALBINO MICE

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    S.Subakanmani

    2012-04-01

    Full Text Available The aim of the present work is evaluate to Anxiolytic profile of Hypericum hookerianum in stress induced Swiss albino mice. The study was carried out using Swiss albino mice (25- 30 g. The Anxiolytic effect of aerial parts of ethanolic extract of Hypericum hookerianum was evaluated by using behavioral analysis like Elevated plus maze (EPM test, Open Field Test (OFT, Hole Board Test (HBT, Light dark exploration Test (LDE in restraint stress induced animals. Behavioral test parameters for anxiety were assessed followed by biochemical parameters (lipid per oxidation, super oxide dismutase, catalase, glutathione per oxidase, reduced glutathione, etc. and Diazepam 1 mg/kg served as a standard Anxiolytic drug, administered intraperitonealy. The results were shown that, ethanolic extract of H.hookerianum (Hh 100mg/kg and Hh 200 mg/kg, p.o. significantly increased the percentage of time spent and number of entries in open arm in EPM. In LDE, the extract produced significant increase in time spent, number of crossing and decrease in the duration of immobility in light box. In OFT, the extract showed significant increase in number of rearings, assisted rearings and number of square crossed, all of which are demonstrations of exploratory behavior. Biochemical analyses revealed an increase in lipid per oxidation, depletion of super oxide dismutase, reduced glutathione, catalase activity and glutathione per oxidase in stress induced animals as compared to unstressed animal. Six days treatment of Hh (100 mg/kg, 200 mg/kg comparable with Diazepam, significantly attenuated restraint stress-induced behavioral and oxidative damage. The results of the present study suggest that an ethanolic extract of H.hookerianum may possess Anxiolytic activity in stressed animals and provide a scientific evidence for its traditional claim.

  13. EFFECT OF FLUORIDE ON KIDNEY OF ALBINO RABBIT-AN EXPERIMENTAL STUDY

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    Santosh K.

    2014-08-01

    Full Text Available BACKGROUND: Fluoride is present in environment in various forms and ingested by man from solid foods, drinks, drinking water and inhaled from the air. Out of these, fluoride is present in large quantities in dissolved state in many sources of drinking water producing toxicity in man. Fluoride, being excreted mainly through the kidneys, seems to damage it causing renal dysfunction. Kidneys are among the most sensitive body organs in their histopathological and functional responses to excessive amounts of fluoride. Trace elements are essential and beneficial to human being in minute concentrations. However, intake in large quantities produces adverse and toxic effects on our body. OBJECTIVE: The present study was designed to investigate the toxic effects (evaluated as histopathological changes of sodium fluoride on the kidney in albino rabbit. MATERIALS AND METHODS: Total 40 albino rabbits were used for this study, among them 8 rabbits were taken in the control group (Group A and16 rabbits each were taken in both group B and group C who were administered low and high dose of fluoride respectively. After 2 weeks interval, up to 16 weeks the histology of the kidney of each group of the rabbit was studied for histological analysis. RESULT: Histological changes in the kidneys of both Group B and Group C rabbits, following continuous daily exposure to sodium fluoride solutions in two different doses (0.5% solution for Group B and 3% solution for Group C for different durations of time were studied in detail and compared with those of the controls (Group A. CONCLUSION: It is concluded that Sodium Fluoride solution in high doses for prolonged period has a definite adverse effect on the renal parenchyma.

  14. In vivo DNA damaging and apoptotic potential of silver nanoparticles in Swiss albino mice

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    Al Gurabi MA

    2015-01-01

    Full Text Available Mohammed A Al Gurabi, Daoud Ali, Saad Alkahtani, Saud Alarifi Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia Abstract: Nanoparticles can potentially cause adverse effects on organs, tissue, cell levels, and protein levels because of their physicochemical properties. Silver nanoparticles (AgNPs are being used on a wide scale in world consumer markets; their potential hazards for humans remain largely unknown. This study aimed to investigate the intraperitoneal toxicity of AgNPs (26 mg per kg of body weight, 52 mg per kg of body weight, and 78 mg per kg of body weight over 72 hours in Swiss albino mice. AgNPs induced a significant increase in serum liver injury markers including alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase. Induction of DNA damage was also studied in mice injected with AgNPs. Apoptosis (detected by using the terminal deoxynucleotidyl transferase deoxyuridine triphosphatase nick end labeling assay method in liver tissue and DNA strand breaks (detected by using the comet assay method in lymphocytes revealed that a concentration of 78 mg of AgNPs per kg body weight can cause significant apoptosis and DNA damage. The DNA damage and apoptosis raise the concern about the safety associated with application of the AgNPs. Significantly more alterations were induced in the hepatocytes of animals exposed to AgNP doses than in the control animals. The induced histological and apoptotic changes may be due to AgNP toxicity. immunohistochemical and ultrastructural of AgNP. Keywords: silver nanoparticles, liver tissue, histology, apoptosis, DNA damage, Swiss albino mice

  15. Effect of Bougainvillea spectabilis Leaves on Serum Lipids in Albino Rats Fed with High Fat Diet

    Directory of Open Access Journals (Sweden)

    H. Saikia

    2011-04-01

    Full Text Available Dyslipidemia is major problem among population those have sedentary life style as well as in diabetics. Bougainvillea spectabilis is most commonly found in India as an ornamental plant and has got anti-diabetic action due to presence of one insulin mimicking agent D-pinitol (3-O-methyl-chiroinositol. The present investigation was undertaken to evaluate the effect of alcoholic extract of leaves of Bougainvillea spectabilis (AEBSL on serum lipid profile in albino rats fed with high fat diet (HFD and to compare it with a standard hypolipidaemic drug simvastatin. Thirty healthy albino rats of both sexes (100-200 g were randomized into 5 groups of 6 animals each. The groups were treated as follows: Group A: normal diet (ND; Group B: HFD (vanaspati ghee + coconut oil mixture in ratio of 3:2 at 10 ml/kg/day; Group C: HFD+ AEBSL (100 mg/kg/day; Group D: HFD + AEBSL (200 mg/kg/day; Group E: HFD + simvastatin (1.8 mg/kg/day. Lipid profile was estimated after 8 weeks of treatment. AEBSL showed a significant (p<0.01 reduction in total cholesterol (TC, Triglyceride (TG, Low density lipoprotein (LDL, Very low density lipoprotein (VLDL levels and significant (p<0.01 increase in high density lipoproteins (HDL in hypercholesteromic rats (Group C and Group D. AEBSL 200 mg/kg/day found to be more effective than AEBSL 100 mg/kg/day. There is also significant improvement in atherogenic index (p<0.01 and increases the percentage of protection AEBSL treated animals. Alcoholic extract of leaves of Bougainvillea spectabilis leaves have excellent lipid lowering potentiality.

  16. Using the Tg(nrd:egfp/albino zebrafish line to characterize in vivo expression of neurod.

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    Jennifer L Thomas

    Full Text Available In this study, we used a newly-created transgenic zebrafish, Tg(nrd:egfp/albino, to further characterize the expression of neurod in the developing and adult retina and to determine neurod expression during adult photoreceptor regeneration. We also provide observations regarding the expression of neurod in a variety of other tissues. In this line, EGFP is found in cells of the developing and adult retina, pineal gland, cerebellum, olfactory bulbs, midbrain, hindbrain, neural tube, lateral line, inner ear, pancreas, gut, and fin. Using immunohistochemistry and in situ hybridization, we compare the expression of the nrd:egfp transgene to that of endogenous neurod and to known retinal cell types. Consistent with previous data based on in situ hybridizations, we show that during retinal development, the nrd:egfp transgene is not expressed in proliferating retinal neuroepithelium, and is expressed in a subset of retinal neurons. In contrast to previous studies, nrd:egfp is gradually re-expressed in all rod photoreceptors. During photoreceptor regeneration in adult zebrafish, in situ hybridization reveals that neurod is not expressed in Müller glial-derived neuronal progenitors, but is expressed in photoreceptor progenitors as they migrate to the outer nuclear layer and differentiate into new rod photoreceptors. During photoreceptor regeneration, expression of the nrd:egfp matches that of neurod. We conclude that Tg(nrd:egfp/albino is a good representation of endogenous neurod expression, is a useful tool to visualize neurod expression in a variety of tissues and will aid investigating the fundamental processes that govern photoreceptor regeneration in adults.

  17. sistema Web con JSP

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    César Viloria Núñez

    2014-01-01

    Full Text Available Este artículo presenta el desarrollo de un sistema de información que permite la adquisición y la administración de información relacionada con los signos vitales como la presión arterial, la frecuencia cardiaca y respiratoria, y la saturación de oxígeno en la sangre de un paciente. La implementación del sistema se basa en una solución Web, permitiendo así que médicos especialistas puedan monitorear a sus pacientes desde cualquier punto conectado a la red en tiempo real y, al mismo tiempo, dar indicaciones críticas al personal médico que se encuentra en el lugar con el paciente.

  18. pacientes con falla cardiaca

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    Diana Marcela Achury Saldaña

    2007-01-01

    Full Text Available Objetivo: determinar la adherencia al tratamiento de pacientes con falla cardiaca hospitalizados, al aplicar un plan educativo quefomenta el autocuidado.Método: estudio cuasiexperimental (entrevistas enfermera-paciente realizado entre diciembre de 2004 y mayo de 2006, con unamuestra de 50 pacientes seleccionados por conveniencia. Se diseñó un instrumento para evaluar los comportamientos de los pacientes,con base en algunos resultados de la adherencia y sus respectivos indicadores de la taxonomía NOC (Nursing out comes classification. Laadherencia al tratamiento fue medida en dos momentos: el primero durante la hospitalización, seguido de la aplicación del plan educativoantes del alta, que proporcionaba información en el manejo de su enfermedad desde una dimensión física, psicológica y social quepromueve el autocuidado; y el segundo un mes después del alta en su domicilio.Resultados: diferencias estadísticamente significativas (P=0,0001 que demuestran cómo mediante la capacitación al paciente enel manejo de su tratamiento farmacológico y no farmacológico, el establecimiento de una sana relación entre el profesional de enfermeríay el paciente, y la participación de la familia, se logra una total adherencia al tratamiento.Conclusiones: para lograr una adherencia total del paciente con falla cardiaca al tratamiento es necesario un proceso educativo y unseguimiento continuo y personalizado que motive permanentemente al paciente y se le reconozca el papel protagónico en su cuidado y manejo de la enfermedad.

  19. Transporte forestal con cables

    OpenAIRE

    Anaya L. Héctor J.

    2012-01-01

    La explotación forestal es un problema fundamentalmente de transporte. El apeo y la preparación de las trozas, aunque a veces presentan algunas dificultades, son operaciones fáciles de resolver comparadas con la operación de transporte la cual absorbe del 60% al 70% o más del costo total del aprovechamiento del bosque. El 30% o 40% restante es absorbido por las faenas previas de apeo y troceo.

  20. Lectura con adolescentes

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    Silvia Méndez Anchía

    2007-01-01

    Full Text Available Con base en la premisa de que la lectura de textos literarios tiene una función formadora y que esta se acentúa en la adolescencia, me propongo demostrar que el cuento “Rapunzel” puede utilizarse como estrategia para explorar algunas situaciones que los sujetos adolescentes perciben como particulares en relación con su vida, pero que se inscriben dentro de grandes problemáticas estudiadas por varias disciplinas. Para ello, he identificado, desde dos marcos de referencia (sociológico y psicoanalítico, diversas problemáticas y discursos que se desprenden de la lectura del cuento realizada por dos mujeres adolescentes, quienes respondieron una guía de lectura y participaron en una entrevista a profundidad. Concluyo que la lectura y comentario del cuento hacen posible que una serie de experiencias que los sujetos adolescentes viven como únicas (como el embarazo de una amiga, las críticas de las personas adultas y las exigencias de padres y madres, ingresen en el circuito de los conocimientos generales al relacionarlas con los discursos y problemáticas en que se inscriben (por ejemplo, el discurso de la “crisis” de la adolescencia, el enfoque de derechos humanos, el mundo fantasmático materno. Por ello, recomiendo la lectura y comentario de textos literarios como estrategia didáctica para contribuir a la elaboración de la subjetividad de personas adolescentes.

  1. Los derechos de los inversores extranjeros sobre la tierra según los tratados de protección de inversiones: una visión desde Latinoamérica

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    Nicolás M. Perrone

    2016-01-01

    Full Text Available En los últimos diez años, la inversión extranjera en agricultura se ha incrementado notablemente en Latinoamérica. Inversores extranjeros tanto privados como estatales están interesados en la producción agrícola, ya sea por el beneficio esperado o para asegurarse el abastecimiento de alimentos. Este aumento de la inversión puede ser positivo para los países de la región. No obstante, para realizar esta determinación, es necesario comprender, entre otros, los efectos legales de estos flujos de inversión. Este trabajo sostiene que los derechos de propiedad que adquieren los inversores extranjeros sobre la tierra y los emprendimientos agrícolas pueden ser diferentes de los derechos de los inversores nacionales Esto se debe a los tratados para la protección de inversión extranjera. El fortalecimiento de los derechos de los inversores extranjeros afecta la relación de estos inversores con los Estados receptores. Este artículo analiza los efectos de los derechos de los inversores extranjeros en relación con cinco categorías de iniciativas estatales. Concretamente, 1 el derecho a exportar la producción o al precio de exportación frente a medidas comerciales y tributarias; 2 el derecho a continuar el proyecto frente a cambios dentro del paradigma regulatorio;3 el derecho a continuar el proyecto frente a cambios de política o nuevas preferencias sociales; 4 el derecho a recibir una compensación mayor frente a reformas agrarias o programas de reparación histórica;5 el derecho a mantener su plan de negocios frente a una crisis alimentaria.

  2. TRATADOS, JUECES Y JUSTICIA EN LA ECONOMÍA Y LOS NEGOCIOS INTERNACIONALES. PERSPECTIVA EN COLOMBIA

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    Jahir Alexánder Gutiérrez Ossa

    2009-11-01

    Full Text Available El propósito del artículo es analizar el papel de la justicia y del juez en los temas económicos y de los negocios internacionales ante los TLC, temas que merecen un estudio profundo por la necesidad de contar con sistemas jurídicos que provean la estructura idónea para responder ante dichos campos. La credibilidad de la justicia referente a estos temas no deja de estar en entredicho. Sin embargo, existe la posibilidad de que la designación de jueces económicos y de negocios internacionales en general pueda mejorar las condiciones en que las empresas se enfrentan ante situaciones de carácter legal. Dicha opción podría generarse si se hace un análisis económico del derecho y de la estructura jurídica. Al respecto, es importante buscar mecanismos que permitan mejorar la acción eficaz de la justicia en los temas económicos y de los negocios internacionales dispuestos en los TLC.

  3. Hematoma após raquianestesia tratado conservadoramente: relato de caso e revisão da literatura Hematoma después de raquianestesia tratado conservadoramente: relato de caso y revisión de la literatura Conservative treatment of hematoma after spinal anesthesia: case report and literature review

    Directory of Open Access Journals (Sweden)

    Daniel Segabinazzi

    2007-04-01

    objetivo de este trabajo fue describir un caso de hematoma después raquianestesia tratado de forma conservadora y revisar los trabajos en la literatura. RELATO DEL CASO: Paciente del sexo masculino, 73 años, 65 kg, 1,67 m, estado físico ASA III. Fue sometido a raquianestesia para retirada de catéter de diálisis peritoneal. Durante la realización de la punción hubo parestesias en el miembro inferior derecho. Se inyectaron 15 mg de bupivacaína hiperbárica a 0,5% sin vasoconstrictor. Veinte y cuatro horas después de la realización del bloqueo el paciente permanecía con anestesia en silla de montar y con dolor lumbar, y 48 horas después del procedimiento presentó una incontinencia urinaria. La resonancia nuclear magnética demostró la existencia de un proceso expansivo subaracnoideo, con compresión de raíces nerviosas (L4 a S1. Después de la evaluación del neurocirujano, se empieza el tratamiento conservador. El paciente recibió alta hospitalaria el 18° día de postoperatorio asintomático. CONCLUSIÓN: El caso presentado mostró una buena evolución con el tratamiento conservador.BACKGROUND AND OBJECTIVES: Spinal anesthesia caries the risk of bleeding. Compression of nervous tissue secondary to the formation of a hematoma can cause neurological damage, which, if not diagnosed and treated in a timely fashion, can be permanent. The identification of risk factors, diagnosis, and early treatment are important for the prognosis. The objective of this report was to describe the case of a hematoma after spinal anesthesia treated conservatively, and review the literature. CASE REPORT: Male patient, 73 years old, 65 kg, 1.67 m, and ASA physical status III, underwent spinal anesthesia for removal of a peritoneal dialysis catheter. During the puncture, the patient experienced paresthesia of the right lower limb. Fifteen milligrams of 0.5% hyperbaric bupivacaine without vasoconstrictor were administered. Twenty-four hours later, saddle anesthesia and lumbar pain

  4. La elevación del seno maxilar en el tratamiento con implantes dentales: un estudio a 4 años

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    A. Jiménez Guerra

    2015-12-01

    Full Text Available Introducción: El objetivo del presente estudio era mostrar los resultados de la elevación del seno maxilar con biomateriales en el tratamiento con implantes del maxilar posterior. Métodos: 70 pacientes edéntulos parciales fueron tratados con 181 implantes Galimplant® con superficie arenada y grabada con ácidos para la rehabilitación del maxilar posterior mediante la técnica de elevación de seno y relleno con betafosfato tricálcico (Osteoblast®. Los implantes fueron cargados después de un periodo de cicatrización de 6-8 meses. Resultados: Los hallazgos clínicos indican una supervivencia y éxito de los implantes del 98,4%. Tres implantes se perdieron durante el periodo de cicatrización. El 85,1% de los implantes fueron insertados simultáneamente a la elevación del seno maxilar. Después de un periodo medio de carga funcional de 57,4 meses, no ha habido complicaciones tardías. El 22,4% de los implantes fueron restaurados con coronas unitarias y el 77,6% con puentes fijos. Conclusiones: Este estudio indica que la rehabilitación del maxilar posterior con implantes mediante la técnica de elevación del seno maxilar constituye un tratamiento dental exitoso.

  5. Note on breeding and parental care behaviours of albino Hoary-bellied Squirrel Callosciurus pygerythrus (Rodentia: Sciuridae in Sibsagar District of Assam, India

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    G. Kalita

    2009-06-01

    Full Text Available A few individuals of albino Horay-bellied Squirrels along with normal gray individuals of Callosciurus pygerythrus have been observed in Sibsagar district of Assam, India. One albino female was studied in captivity. This paper presents our observations on the breeding behaviour and the parental care exhibited by the albino squirrel in captivity. The squirrel bred twice in captivity with a normal male of the same species. In both the periods, a single male baby with normal coat colour developed. Oral dose of vitamin E has been found helpful in the breeding of the studied squirrel species. The mother squirrel exhibited parental care by carrying her baby using her mouth, to a safer place during danger. However, the observed phenomenon is unlike that of the cat species. Some of the habitat ecology and feeding habits of the albino squirrels have also been studied, both in natural and in captive conditions.

  6. Cementos con cenizas volantes

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    Ossa M., Mauricio

    1984-03-01

    additions of 20 and 30% .

    Casi la generalidad de los estudios realizados sobre cementos con adición de cenizas volantes se refieren a sus características y comportamiento en pastas, morteros y hormigones, siempre en relación con aquéllos del cemento portland. Esta vez, se desarrolló un trabajo experimental orientado a relacionar entre sí los cementos con adiciones de cenizas volantes y de puzolana natural. Para ello se fabricaron a escala de laboratorio cementos de ambos tipos, empleando como materias primas comunes clinker y yeso y, como variables, diferentes porcentajes de las dos adiciones, que cumplieron previamente los requisitos normalizados en cuanto a sus actividades puzolánicas. La calidad de los cementos fabricados resultó adecuada y concordante con la del cemento portland-puzolánico obtenido a escala industrial con los mismos clinker, yeso y puzolana natural de este estudio. Posteriormente, se determinaron las características de los cementos experimentales y se confeccionaron morteros normales para la realización de ensayos físicos y mecánicos. Los resultados de ensayos indicaron que los cementos con adición de cenizas volantes (CCV requieren menos agua para consistencia normal, presentan tiempos de fraguado mayores y expansiones en autoclave menores que los cementos con adición de puzolana (CP. Los calores de hidratación a 7 y 28 días de edad fueron aproximadamente similares para ambos tipos de cemento. En morteros normales, los cementos CCV mostraron menor retracción de secado, mayor retentividad y mayor fluidez (para igual cantidad de agua que los cementos CP. En los ensayos de exudación se observó que ésta depende más de la finura que el tipo de adición. Finalmente, los ensayos mecánicos señalaron que las resistencias a compresión y flexotracción de los morteros con cementos CCV son menores a edades inferiores que 14 días (del orden de 5 a 10% a un día de edad, pero que a partir de entonces pasan a ser mayores que las de

  7. Fracturas de clavícula. Tratamiento quirúrgico con clavos intramedulares flexibles

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    Roberto Joaquín Del Gordo D'amato

    2014-05-01

    Full Text Available Se realizó un estudio de tipo descriptivo en una serie de casos en el cual se presentan los resultados de 12 fracturas de clavícula tratadas en forma quirúrgica mediante clavos intramedulares flexibles. Todos los pacientes fueron tratados por los autores en la Clínica El Prado del D.T.C.H. de la Ciudad de Santa Marta mediante reducción cerrada bajo control radioscópico. Presentando resultados excelentes y buenos en todos los casos. Así mismo, se evidenció consolidación clínica a las cuatro semanas con reintegro a la vida laboral alrededor de las seis semanas. Todos los pacientes mostraron alto grado de satisfacción con el resultado obtenido. Se concluye que el tratamiento empleado es una alternativa terapéutica a tener en cuenta en aquellas fracturas desplazadas, sean estas del tercio externo, medio o interno que permite consolidación sin las complicaciones que con alguna frecuencia se presentan con el tratamiento conservador. (Duazary 2006; 2:115-120

  8. Protective effect of Tribulus terrestris L. fruit aqueous extracton lipid profile and oxidative stress in isoproterenol induced myocardial necrosis in male albino Wistar rats

    OpenAIRE

    Sailaja, K.V.; Shivaranjani, V. Leela; Poornima, H.; Rahamathulla, S.B.Md.; Devi, K. Lakshmi

    2013-01-01

    The objective of the present study was to evaluate the possible protective effects of Tribulus terrestris fruit aqueous extract (TTFAEt) on lipid profile and oxidative stress in isoproterenol (ISO) induced myocardial necrosis in albino Wistar rats. Albino Wistar rats were divided into normal control, TTFAEt alone treated, ISO control and pretreated (TTFAEt+ISO) groups. The extract was administered at a dose of 50 mg/kg body weight for 40 days orally by gavage and ISO was administered at a dos...

  9. Protective effect of Tribulus terrestris L. fruit aqueous extract on lipid profile and oxidative stress in isoproterenol induced myocardial necrosis in male albino Wistar rats

    OpenAIRE

    K. Lakshmi Devi; Poornima, H.; Rahamathulla, S.B.Md.; Sailaja, K.V.; Shivaranjani, V. Leela

    2013-01-01

    The objective of the present study was to evaluate the possible protective effects of Tribulus terrestris fruit aqueous extract (TTFAEt) on lipid profile and oxidative stress in isoproterenol (ISO) induced myocardial necrosis in albino Wistar rats. Albino Wistar rats were divided into normal control, TTFAEt alone treated, ISO control and pretreated (TTFAEt+ISO) groups. The extract was administered at a dose of 50 mg/kg body weight for 40 days orally by gavage and ISO was administered at...

  10. Differential effects of alprazolam and clonazepam on the immune system and blood vessels of non-stressed and stressed adult male albino rats

    OpenAIRE

    Elmesallamy, Ghada E.; Abass, Marwa A.; Ahmed Refat, Nahla A.G.; Atta, Amal H.

    2011-01-01

    Benzodiazepines belongs to one of the most commonly used anxiolytic and anticonvulsant drugs in the world. Full description of toxic effects on different organs is lacking for nearly all the current benzodiazepines. The aim of the current work was to study the immunologic and vascular changes induced by sub-chronic administration of alprazolam and clonazepam in non-stressed and stressed adult male albino rats. Forty-two adult male albino rats were divided into 6 groups (I): (Ia) Negative cont...

  11. Evaluation of cardioprotective effect of aqueous extract of Garcinia indica Linn. fruit rinds on isoprenaline-induced myocardial injury in Wistar albino rats

    OpenAIRE

    Patel, Kaksha J.; Ashwin K. Panchasara; Manish J Barvaliya; Purohit, Bhargav M.; Seema N Baxi; Vadgama, Vishal K.; Tripathi, C.B.

    2015-01-01

    In the present study, cardioprotective effect of aqueous extract of Garcinia indica Linn. fruit rinds in isoprenaline-induced myocardial infarction in Wistar albino rats was evaluated. In vitro total phenolic, total flavonoid content and 2, 2’-diphenyl-1-picrylhydrazyl hydrate radical scavenging activity was measured. In vivo effect of aqueous extract of G. indica was evaluated in Wistar albino rats by isoprenaline-induced myocardial injury model. Thirty six rats were randomly divided in 6 gr...

  12. Evaluacion de las alteraciones conductuales y dopaminergicas en ratones con bajas concentraciones de plomo.

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    N. Martínez Riera

    2001-01-01

    Full Text Available La investigación de los efectos del plomo en animales de experimentación y sus consecuencias en el desarrollo neurológico conductual es compleja y controvertida. Conociendo que la maduración neurológica de los ratones ha culminado en edades que oscilan entre los 25-35 días, nuestro objetivo ha sido investigar si la administración de soluciones de diferentes concentraciones de plomo, durante tiempos establecidos de acuerdo a las dosis-ingesta, producía alteraciones en los juegos solitarios en animales de experimentación adultos. Se trabajó con ratones adultos de ambos sexos de la cepa C3H, alimentados con dieta estándar y agua ad libitum. Se utilizaron seis lotes: tres experimentales que fueron tratados con acetato de plomo en el agua de bebida en diferentes concentraciones: 1, 1000 y 2000 ppm y en los tres grupos controles, la ingesta fue de agua potable. En este trabajo se estudiaron los juegos solitarios de los animales: 1 Actividad locomotora, 2 Aseo total, 3 Exploración subterránea (en tiempo y frecuencia y 4 Exploración aérea total. Se determinó el nivel de dopamina presente en el cerebro de los mismos por espectrofluorometría. Los resultados obtenidos de las alteraciones conductuales en los animales de experimentación analizados con tests no paramétricos fueron: disminución significativa de la actividad locomotora (número de cuadros, de la exploración subterránea (en tiempo, de la exploración aérea (en tiempo y del aseo total, no observándose variaciones significativas en la exploración subterránea (en frecuencia. Las variables investigadas estarían mediadas por distintos sistemas de neurotrasmisión. En la dopamina determinada en cerebro de ratones con ingesta de plomo de 1 - 1000 - 2000 ppm se encontró disminución significativa de la misma en los ratones tratados con respecto a los grupos controles.

  13. Biosíntesis de dextranos de alto peso molecular mediante la inoculación con Leuconostoc Mesenteroides, var. Mesenteroides (atcc 10830 de jugos residuales de la agroindustria de la piña: síntesis y caracterización de hierro-dextranos

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    José Roberto Vega Baudrit

    2013-01-01

    Full Text Available En este trabajo se muestran los estudios realizados para obtener dextranos a partir de desechos de la agroindustria de piña. La fermentación se llevó a cabo en un biorreactor (10 L, se inoculó con un cultivo de Leuconostoc mesenteroides, var. mesenteroides (ATCC 10830. Se centrifugó y se precipitó y purificó con etanol. Fue caracterizado por medio de viscosidad, peso molecular y grupos funcionales por espectroscopía infrarroja. Este dextrano fue tratado con el fin de obtener hierro-dextranos.

  14. Estudio del comportamiento del pH en filetes de pejerrey de laguna (Odonthestes bonariensis), conservados con y sin vacío, utilizando distintos tratamientos y almacenados a temperaturas de 4,0 y -1.5º C

    OpenAIRE

    Copes, Julio; Pellicer, K.; Hoyo, G. del; Brocardo, S.; Giannuzzi, Leda

    2008-01-01

    En la industria pesquera, la medición del pH es una variable que reviste gran importancia al momento de juzgar la frescura de los productos derivados de la pesca. El objetivo de este trabajo fue estudiar el comportamiento del pH a partir de filetes de pejerrey de laguna (Odonthestes bonariensis), conservados con y sin vacío, tratados con agua clorada y agua clorada con ácidos cítrico y ascórbico, almacenadas a 4, 0 y -1.5 °C. Se obtuvieron diferencias significativas entre los filetes de pejer...

  15. Evaluación de las técnicas de cepillado de bass y vertical en un grupo de pacientes en tratamiento de ortodoncia con técnica mbt

    OpenAIRE

    Yelitza Ivone Baracaldo Ortíz; Fredy Alexander Cabuya Cabuya; Rubén Darío Hurtado Rozo; Edwin Emil Ricaurte Vila; Diana Constanza Gamboa Martínez; Liliana Carolina Báez Quintero

    2012-01-01

    Objetivo: Evaluar la efectividad de las técnicas de Cepillado de Bass y Vertical en pacientes con aparatología ortodóntica fija tratados con la técnica MBT. Materiales y métodos: se realizó un estudio experimental “In vivo” aleatorizado doble ciego; la muestra fue de 100 personas distribuidas en dos grupos, a cada uno se le asignó una Técnica de Cepillado y se dieron instrucciones de higiene oral por medio de charlas personalizadas y por escrito. Se usó el índice de Sillnes y Löe para medir e...

  16. Funciones con Microsoft Excel

    OpenAIRE

    Castillo, Dalia Imelda; Estrada, Ana Luisa; Hernández, Brenda Amalia

    2009-01-01

    En este documento se presenta el desarrollo de algunas actividades que se trabajaron con estudiantes de primer semestre de la Universidad Autónoma de Nayarit; utilizando la hoja de cálculo Excel en el tema de visualización de funciones, para la materia de lenguaje y pensamiento matemático. Ya que la tecnología ha adquirido un papel muy importante en el proceso enseñanza-aprendizaje, nos ofrece un medio para que el estudiante explore, analice, verifique y desarrolle habilidades que se serán út...

  17. Creo con mis dedos

    OpenAIRE

    S??nchez Aniceto, Monta??a

    2015-01-01

    Las artes pl??sticas son muy importantes para los ni??os/as sobre todo para Educaci??n Infantil ya que promueven la creatividad mediante diferentes recursos y t??cnicas lo que favorece su motivaci??n en las competencias desde la edad temprana hasta la adolescencia. Es la primera forma que tiene el ni??o/a de expresarse en el mundo (a trav??s de los garabatos), de comunicarse, compartir sus emociones con los dem??s, creando su propio lenguaje que evolucionar?? hacia el lenguaje oral y escri...

  18. Mayonesa con quitosano

    OpenAIRE

    Gaffrey, María Celeste

    2014-01-01

    Introducción: El quitosano es un polímero natural que se obtiene a partir de la quitina, la cual forma parte de la estructura de soporte de numerosos organismos vivos, tales como artrópodos (crustáceos e insectos), moluscos y hongos. Presenta propiedades aplicables en los alimentos, como estabilizante, emulsificante, y quelante. No puede ser digerido por los seres humanos por lo cual está considerado como una fibra dietética con un contenido calórico cero. Objetivos: Evaluar...

  19. Eugenistas, pero con prudencia

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    Pogliano, Claudio

    1999-12-01

    Full Text Available Thinking that one could not describe eugenics like a unique movement, since numerous bound varians took place related to the geographical and cultural context, this article tries to demostrate the peculiarity of the Italian case. If already in 1889 Giuseppe Sergi wanted that the artificial selection take it to end what should make the natural, avoiding the risk of the so called «degeneration», only in the face of the First World War seems to grow the alarm for the decadent quality of the population, finding a more and more wide echo. In 1919 the Siges was born (Società italiana de genetica ed eugenica shocked under the impression of the difusse fear about the butcher the war had caused. From there from now on fastens a «nazional» direction closely related to the traditional thought and also with the new political temper. A «moderate» direction, Fascist, Catholic, that was built in consonance with the pronatalism of the regime and in rough polemic with the presumed Anglo-Saxon eugenics aberration.

    Partiendo de la base de que no se puede describir la eugénica como un movimiento unitario, ya que se produjeron numerosas variantes ligadas al contexto geográfico y cultural, este artículo intenta demostrar la peculiaridad del caso italiano. Si ya en 1889 Giuseppe Sergi deseaba que la selección artificial llevase a cabo lo que debía de hacer la natural, evitando así el riesgo de la «degeneración », sólo ante la Primera Guerra Mundial parece crecer la alarma por la decadente calidad de la población, encontrando un eco cada vez más amplio. En 1919 nació la Sige (Società italiana de genetica ed eugenica bajo la impresión del difuso temor que la carnicería bélica había provocado. De ahí en adelante prende rápidamente una dirección «nazional» que se imbrica tanto con una tradición del pensamiento como con el nuevo temple político. Una dirección «moderada» fascista, católica, que se construyó en consonancia con el

  20. Conversando con... BENEDETTA TAGLIABUE

    OpenAIRE

    Torres, Ana; Cabanes, Miguel

    2011-01-01

    Esta entrevista se realiza en el marco del XIII Congreso Internacional de Expresión Gráfica Arquitectónica realizado en la Escuela Técnica Superior de Arquitectura de Valencia los días 27 al 30 de Mayo de 2010.Benedetta Tagliabue es, en la actualidad, una de las arquitectas con mayor prestigio en el panorama internacional. El Pabellón de España para la Expo de Shanghai 2010, es una de sus últimas obras más representativas, en el que se acentúa y desarrolla un conjunto de características arqui...

  1. Qualidade pós-colheita de quivi 'Hayward' tratado com 1-MCP e armazenado sob diferentes atmosferas

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    Marcelo José Vieira

    2012-06-01

    Full Text Available Este trabalho teve por objetivo avaliar o efeito do 1-MCP sobre o amadurecimento e a qualidade pós-colheita de quivi 'Hayward' armazenado sob diferentes atmosferas. Foram conduzidos dois experimentos, com frutos colhidos em pomar comercial localizado em Fraiburgo-SC. No experimento 1, os frutos foram tratados com três doses de 1-MCP (0,0; 0,5 ou 1,0 µL L-1 e armazenados sob atmosfera controlada (AC, contendo 2,0kPa de O2 + 4,5kPa de CO2, a 0ºC ± 0,5ºC, 92 ± 3% UR, e com <40 ηL L-1 de etileno no ambiente, durante 90 e 120 dias, mais sete dias de vida de prateleira a 23ºC. No experimento 2, os frutos foram tratados com 0,0 ou 0,7 µL L-1 de 1-MCP e armazenados sob atmosfera ambiente (AA, contendo 21 kPa de O2 + 0,03 kPa de CO2, a 0 ± 0,5ºC, 90 ± 3% UR, e com 200 a 250 ηL L-1 de etileno no ambiente, durante 30, 60, 90 e 120 dias, mais um e sete dias de vida de prateleira a 23ºC ou AC (contendo 2,0 kPa de O2 + 4,5 kPa de CO2, a 0ºC ± 0,5ºC, 92 ± 3% UR, e com <40 ηL L-1 de etileno no ambiente, durante 60, 90, 120 e 150 dias, mais um e sete dias de vida de prateleira a 23ºC. Os benefícios do tratamento com 1-MCP sobre a conservação da qualidade foram observados tanto para frutos armazenados sob AA quanto sob AC. No experimento 1, não houve diferença entre as doses de 1-MCP de 0,5 e 1,0 µL L-1 sobre o controle do amadurecimento e manutenção da qualidade dos frutos armazenados em AC. No experimento 2, o tratamento com 1-MCP retardou o aumento na taxa de produção de etileno após remoção de câmara fria. A redução da taxa de produção de etileno nos frutos tratados com 1-MCP foi associada ao aumento na conservação da firmeza da polpa sob AC e AA, e redução na incidência de pericarpo translúcido sob AA. O potencial de armazenamento foi aumentado pelo tratamento com 1-MCP em aproximadamente 60 e 30 dias, nos frutos armazenados sob AA e AC, respectivamente.

  2. Outcome of sporadic amyotrophic lateral sclerosis treated With non-invasive ventilation and riluzole Sobrevida en pacientes con esclerosis lateral amiotrófica esporádica tratados con ventilación no invasiva y riluzole

    OpenAIRE

    Martín Sívori; Gabriel E. Rodríguez; Daniel Pascansky; César Séenz; Roberto E.P. Sica

    2007-01-01

    Sporadic amyotrophic lateral sclerosis (sALS) is a progressive degenerative motor neuron disorder lacking specific treatment. Riluzole is the only drug able to modestly slow down the course of the disease. Respiratory insufficiency is the main cause of death; non invasive ventilation (NIV) has shown to improve survival. Our aim was to evaluate the effect of NIV and riluzole on survival. Ninety seven patients with a diagnosis of sALS were assessed and followed up for 60 months. Twenty nine pat...

  3. Segumiento de la carga tumoral en pacientes con leucemia mielode crónica de novo y en remisión citogenética completa tratados con imatinib en Colombia

    Directory of Open Access Journals (Sweden)

    Gonzalo Guevara

    2012-12-01

    Full Text Available Normal 0 21 false false false ES X-NONE X-NONE Objective: To evaluate the hematological, cytogenetic, and molecular responses in Colombian patients with CML chronic myeloid leukemia (CML treated with imatinib. Methods: Two groups of patients, one with the novo diagnostic and another in state of complete cytogenetic remission were followed for 12 months with quantitative PCR evaluations every three months and with chromosomal analysis every 6 months. Results: The group with the novo diagnosis showed 50% of complete cytogenetic remission at 12 months while the other 50% were considered to have primary resistance. Respect the molecular analysis, 10.5% of the patients reached undetectable BCR-ABL transcripts at 12 months. In the complete cytogenetic remission group, 10.6% lost the state of complete cytogene­tic remission at 12 months, 50% reached undetectable BCR-ABL transcripts but 10% showed levels higher than 10%, which in our standardization was equal to no molecular response. Conclusions: Despite having received the conventional dosages of 400 mg/day of imatinib, the cytogenetic and molecular responses obtained in our group of Colombian patients with CML, were lower than those in other international studies.

  4. Evaluación de la expresión de las proteínas PPARγ Y NFκB en vellosidades intestinales de ratones adultos ICR infectados con rotavirus ECwt y tratados con pioglitazona

    OpenAIRE

    Gómez Moreno, Dory Lineth

    2013-01-01

    ANTECEDENTES Rotavirus es la principal causa de diarrea severa en niños menores de cinco años de edad en todo el mundo, según la OMS, rotavirus causa aproximadamente 527.000 muertes cada año (1). Dos vacunas de rotavirus vivos atenuados (Rotarix ™) y (RotaTeq ™) están disponibles actualmente (2). Aunque estas vacunas han demostrado su eficacia, no evita la aparición de los síntomas y muchos niños permanecen sin vacunar. Por consiguiente, se necesitan alternativas farmacológicas para el tra...

  5. Three-dimensional verification of prostate cancer patients treated with VMAT by Matrixx detector and COMPASS software IBA; Verificacion tridimensional de pacientes con cancer de prostata tratados con VMAT mediante el detector Matrixx y software COMPASS de IBA

    Energy Technology Data Exchange (ETDEWEB)

    Mateos, J. C.; Luis, F. J.; Cabrera, P.; Carrasco, M.; Sanchez, G.; Herrador, M.

    2011-07-01

    Described in this paper the verification of prostate cancer patients treated with VMAT planned in our hospital, with a prescribed dose of 76 Gy. The ability to simultaneously analyze the patient by any plane COMPASS software (IBA, Germany), together with the detector array Matrixx-Evolution, this system gives a particularly interesting feature. The aim of this paper is to describe the operation of this equipment and validated for patient dosimetry in IMRT and VMAT treatments.

  6. Perfil eletrocardiográfico e conteúdo glicogênico muscular de ratos tratados com nandrolona

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    Carlos Alberto da Silva

    2010-12-01

    Full Text Available FUNDAMENTO: Considerou-se o uso indiscriminado de esteroides tanto por atletas de elite quanto por praticantes de atividades físicas. OBJETIVO: Avaliar os efeitos do decanoato de nandrolona sobre o perfil eletrocardiográfico, conteúdo glicogênico e de proteínas totais dos músculos cardíacos e esqueléticos, bem como as concentrações plasmática de albumina. MÉTODOS: Os animais do grupo tratado receberam a droga na concentração 5 mg/kg pela via subcutânea, duas vezes por semana, durante três semanas. Uma vez por semana, os ratos foram anestesiados com Pentobarbital sódico (50 mg/kg, ip e submetidos à avaliação por meio do eletrocardiograma (ECG. Após o período experimental, amostras dos músculos cardíaco (ventrículo esquerdo - VE, sóleo (S, gastrocnêmio branco (GB, gastrocnêmio vermelho (GV, peitoral (P, intercostal (IC e diafragma (D foram prontamente coletadas e analisadas. Os dados (média ± epm foram avaliados de acordo com ANOVA, segundo teste de Tukey (p>0,05. RESULTADOS: Os ratos do grupo tratado apresentaram alterações nos seguintes parâmetros cardíacos: intervalo QRS, intervalo QTc e frequência cardíaca, caracterizados por um aumento desses, tendo o ápice no intervalo da semana de pré-tratamento para a primeira semana. As reservas de glicogênio no VE apresentaram aumento de 127%. Em relação à quantidade de proteínas totais, a diferença significativa foi constatada no S, GV e D. Quanto ao perfil bioquímico e ao hematócrito, foi observado um aumento na porcentagem de eritrócitos. CONCLUSÃO: O estudo mostra que importantes alterações cardíacas são deflagradas precocemente, sugerindo uma hierarquia na sequência de modificações que comprometem a homeostasia do organismo.

  7. Análise epidemiológica de 210 casos de hematoma extradural traumático tratados cirurgicamente

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    João Luiz Vitorino Araujo

    2012-08-01

    Full Text Available OBJETIVO: Analisar aspectos da epidemiologia, apresentação clínica e radiológica de pacientes com hematoma extradural traumático (HED submetidos a procedimento neurocirúrgico. MÉTODOS: Foi realizada a revisão de prontuários de 210 pacientes admitidos no Serviço de Emergência com HED diagnosticados através de tomografia computadorizada, tratados cirurgicamente no período de agosto de 1998 a janeiro de 2008. Foram analisados: idade, sexo, apresentação clínica e radiológica, mecanismo de trauma e status neurológico no momento da alta hospitalar. RESULTADOS: Em 49,2% o mecanismo de trauma foi queda; 89,2% dos pacientes eram do gênero masculino; 49,7% dos casos tinham Escala de Coma de Glasgow (ECG entre 13-15; 61% dos pacientes tinham idade entre 20-49 anos; A localização do HED em 26,5% e 19,6% dos casos foi têmporo-parietal e temporal, respectivamente; 32,8% tinham lesões intracranianas associadas, sendo a fratura craniana evidenciada em cerca de 45% dos casos; 76,2% dos pacientes tratados cirurgicamente tiveram alta com déficit mínimo ou ausência de déficit neurológico. CONCLUSÃO: Observamos que o HED, na população de estudo, apresenta-se mais frequentemente no gênero masculino, na quarta década de vida, mais relacionado às quedas. Na admissão, observamos uma ECG entre 13 e 15, sendo pertinente mencionar o envolvimento da região têmporo-parietal na maioria dos casos. Acreditamos que o conhecimento da epidemiologia do hematoma extradural traumático pode auxiliar na elaboração de medidas de saúde pública, visando à prevenção e identificação precoce desta doença em determinada população.

  8. con la cosecha mecanizada

    Directory of Open Access Journals (Sweden)

    Arturo Martínez Rodríguez

    2006-01-01

    Full Text Available Las investigaciones dirigidas a incrementar los indicadores de eficiencia y calidad durante la cosecha mecanizada del café, constituyen un tema de gran actualidad a nivel internacional. La determinación de las propiedades físico-mecánicas de los frutos y del sistema frutopedúnculo, es una etapa indispensable durante las investigaciones relacionadas con la cosecha mecanizada de este producto. En este trabajo se brindan los resultados sobre la determinación de un grupo de propiedades dimensionales, inerciales y elásticas del sistema fruto-pedúnculo de coffea arabica variedad Catuai en diferentes estadios de maduración, relacionadas con la cosecha mecanizada de este cultivo.Así mismo se determina el momento flector requerido para la ruptura de la unión fruto pedúnculo. Durante la investigación se emplearon técnicas de procesamiento de imágenes digitales, así como de extensometría eléctrica. Como resultado de la medición de las diferentes propiedades se apreciaron diferencias sustanciales en las características dimensionales, inerciales y elásticas de los frutos maduros y verdes, así como en el momento requerido para el desprendimiento de los frutos y en las formas en que se produce el desprendimiento.

  9. Garlic (Allium sativum) Extract Supplementation Alters the Glycogen Deposition in Liver and Protein Metabolism in Gonads of Female Albino Rats

    OpenAIRE

    Sashank Srivastava; P. H. Pathak

    2012-01-01

    Garlic is an ayurvedic herb that has been extensively used as medication and as the taste enhancer of the food. The present investigation was undertaken to provide data on the efficacy of garlic (Allium sativum Linn.) extract on glycogen deposition and protein metabolism in female albino rats that may further explore medicinal potential of garlic. The rats were divided into four groups A, B, C and D, keeping group A as a healthy control. The garlic extract was tried in three different doses, ...

  10. Effects of Calendula Essential Oil-Based Cream on Biochemical Parameters of Skin of Albino Rats against Ultraviolet B Radiation

    OpenAIRE

    Mishra, Arun K.; Mishra, Amrita; Verma, Anurag; Chattopadhyay, Pronobesh

    2012-01-01

    Reactive oxygen species (ROS) generated from UV-B radiation have the capacity to cause oxidative decomposition which leads to the formation of toxic components as well as lipid peroxidation. Considering this fact, the present study was performed to evaluate the effect of a cream (O/W) containing the essential oil of Calendula officinalis on biochemical parameters of the skin of albino rats against UV-B radiation. The fingerprint analysis of Calendula essential oil was performed by HPLC with s...

  11. Evaluation of anti-depressant and anxiolytic activity of Rasayana Ghana Tablet (A compound Ayurvedic formulation) in albino mice

    OpenAIRE

    Deole, Yogesh S.; Chavan, Sulakshan S.; Ashok, B. K.; Ravishankar, B.; Thakar, A.B.; Chandola, H. M.

    2011-01-01

    In recent years, many Ayurvedic formulations are being researched to provide an effective antidepressant and anxiolytic drug in the field of psycho-pharmacology. The present study was planned to evaluate the anti-depressant and anxiolytic activity of Rasayana Ghana Tablet comprising three herbs Guduchi (Tinospora cordifolia Miers), Aamalaki (Emblica officinalis Garten) (RGT) and Gokshura (Tribulus terrestris Linn). Swiss albino mice were divided into four groups of six animals each, comprisin...

  12. Effect of aqueous extract of Tinospora cordifolia on functions of peritoneal macrophages isolated from CCl4 intoxicated male albino mice

    OpenAIRE

    Sharma Gauri D; Sengupta Mahuya; Chakraborty Biswajit

    2011-01-01

    Abstract Background The current practice of ingesting phytochemicals for supporting the immune system or fighting infections is based on centuries-old tradition. Macrophages are involved at all the stages of an immune response. The present study focuses on the immunostimulant properties of Tinospora cordifolia extract that are exerted on circulating macrophages isolated from CCl4 (0.5 ml/kg body weight) intoxicated male albino mice. Methods Apart from damaging the liver system, carbon tetrach...

  13. Effect of Some Food Colorants (Synthetic and Natural products) of Young Albino RatsI- Liver and Kidney Functions

    OpenAIRE

    Eman G.E. Helal * Samir A.M. Zaahkouk

    2000-01-01

    Food colorants are used all over the world in great amount. However, their use in food is still controversial. It causes and will cause severe tension to the consumers as the sensitivity of people increases to general health. This work was carried out to study and compare between the possible toxic effect of some natural (tumeric, carmine and chlorophyll) and synthetic (fast green, annatto and sunset-yellow), food colorants on liver and kidney function of young male albino rats. Such effect m...

  14. Estudo quantitativo do nervo frênico de rato albino em função do envelhecimento

    Directory of Open Access Journals (Sweden)

    Romeu Rodrigues de Souza

    1990-01-01

    Full Text Available The phrenic nerve of albino rats was studied for age changes in number of fibres, myelin sheath thickness and axon calibre. Nerves were excised from three young and three aged rats. There is no significant morphological differences between nerves from young and aged rats and no difference with age was found in the number of fibres, myelin sheath thickness and axon calibre.

  15. Effect of saffron (Crocus sativus L.) on sodium valporate induced cytogenetic and testicular alterations in albino rats

    OpenAIRE

    Sakr, Saber A.; Zowail, Mohamed E.; Marzouk, Amera M.

    2014-01-01

    The present study investigated the cytogenetic and testicular damage induced by the antiepileptic drug, sodium valporate (SVP) in albino rats and the effect of saffron aqueous extracts. Treating rats with SVP caused a significant increase in the chromosomal aberrations either structural or numerical and decreased the mitotic index. Besides, animals administered SVP showed DNA damage appeared in the single strand breaks (comet assay). Testis of SVP-treated rats showed many histopathological ch...

  16. Comparison of the efficacy of sitagliptin with pioglitazone on dexamethasone-induced hepatic steatosis, dyslipidemia, and hyperglycemia in albino rats

    OpenAIRE

    Paul Mathai; Nagendra Nayak; Mamtha Rao; Nitasha Bhat, G. M.; K. Vinodraj; N Chandralekha; D Rajesh; T. K. Chethan

    2015-01-01

    Background: Sitagliptin is a dipeptidyl peptidase type 4 inhibitor. This study was done to assess the insulin-sensitizing effect of sitagliptin on Wistar albino rats by means of surrogate measures. Methods: There were four groups of six rats each. First group received dexamethasone alone in a dose of 8 mg/kg intraperitoneally for 6 days to induce metabolic changes and considered as dexamethasone control. Second group received sitagliptin 100 mg/kg orally 6 days before dexamethasone and 6 d...

  17. Evaluation of genotoxic potential of Hypericum triquetrifolium extract in somatic and germ cells of male albino mice

    OpenAIRE

    Bushra M. A. Mohammed,; Sarbast K. Q. Kheravii

    2011-01-01

    Hypericum triquetrifolium aqueous extract were studied for the first time for its toxic and the possible clastogenic effects in vivo on the bone marrow and spermatozoa cells of Swiss albino mice. The lethal dose of the aqueous extract was considered to be 10.33 g/kg of the body weight, injected subcutaneously. The doses which were chosen for treatments were 2, 1, and 0.25 g/kg. H. triquetrifolium extract induce statistically significant increases in the average...

  18. Comparison of the efficacy of liraglutide with pioglitazone on dexamethasone induced hepatic steatosis, dyslipidemia and hyperglycaemia in albino rats

    OpenAIRE

    Vinodraj, K.; Nagendra Nayak, I. M.; Rao, J. Vikram; Mathai, Paul; N Chandralekha; Nitasha, B.; D. Rajesh; T. K. Chethan

    2015-01-01

    Objectives: To evaluate the efficacy of liraglutide with pioglitazone for prevention of dexamethasone induced hepatic steatosis, dyslipidemia and hyperglycemia in Albino rats. Materials and Methods: There were four groups of six rats each. First group received dexamethasone alone in a dose of 8 mg/kg intraperitoneally for 6 days to induce metabolic changes and considered as dexamethasone control. Second group received liraglutide 1.8 mg/kg subcutaneously 6 days before dexamethasone and 6 days...

  19. Phytic Acid Exposure Alters AflatoxinB1-Induced Reproductive and Oxidative Toxicity in Albino Rats (Rattus norvegicus)

    OpenAIRE

    Abu El-Saad, Abdelaziz S.; Mahmoud, Hamada M.

    2009-01-01

    The increased use of feed in Egypt's aquaculture and animal industries raises concerns about the possible presence of mycotoxins in feedstuffs. The use of alternative medicine, such as botanicals and nutritional supplements, has become popular with inflammatory cases. The present study aimed to testify the role played by phytic acid (IP6) in enhancing the reproductive and oxidative toxicity induced in aflatoxinB1 (AFB1) treated white male albino rats (Rattus norvegicus) throughout treatment a...

  20. Structural And Histochemical Changes Of Albino Rat Kidney Under The Effect Of Injectable Contraceptive

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    Mamdouh A. Ghali

    2006-03-01

    Full Text Available The choice of safe and effective method for fertility control still under continuous search. So, discovery of structures having long duration of action which made administration by injection was an attractive alternative to oral contraceptives. Medroxyprogesterone acetate emerged from this early work as promising injectable long ­ acting contraceptive with minimal risk. This work was planned to evaluate the structural and histochemical changes induced by injectable contraceptive Depo-provera (MPA, on the kidney of adult female Albino rats as well as testing the degree of reversibility of changes that may develop after the arrest of its use. Thirty adult female Albino rats were used in this work and divided into three equal groups. Group I was used as a control, group II was intramuscularly injected with MPA 4 times (2.7 mg / rat every 3 oestrus cycles and sacrificed one day after arrest of the injection, while , group III the animals were injected with MPA by the same dose and sacrificed 30 days after arrest of the injection. The abdominal aorta was exposed and Indian ink injection was injected to study the renal vascular changes. The animals were sacrificed, the kidney was dissected and paraffin sections were prepared and stained by haematoxylin and eosin and PAS technique to study the microscopic structure and the distribution of PAS+ve materials respectively. Frozen sections were prepared and stained by both Gomori and Nachla's techniques to study the activity of acid phosphatase enzyme and succinic dehydrogenase enzyme respectively. The obtained data were statistically analyzed using Student's t.test. The injected groups showed atrophy of tubular epithelium, dilatation of tubular lumina. All recovery groups were nearly similar to normal state except PAS+ve material of renal tubules which were nearly similar to injected groups. The treated groups showed significant increase in vascular distribution and PAS+ve materials. While, non

  1. Effects of ciprofloxacin and zinc chloride in adult albino rat and pre-natal conceptus

    International Nuclear Information System (INIS)

    Background: Administration of quinolone therapy is controversial during growing age as stated by earlier authors. The flouroquinolones are currently not indicated for young children because of arthropathy and adverse effect as new born shown by studies. However the effects of ciprofloxacin and ZnCl/sub 2/ on prenatal conceptus have remained undocumented. The present study was designed to compare the effects on conceptus after maternal ingestion of ciprofloxacin and ZnCl/sub 2/ using Wastar albino rats. Methods: Ciprofloxacin and ZnCl/sub 2/ was administrated to pregnant female albino rats. Ciprofloxacin with a dose of 20 mg/Kg bodyweight and ZnCl/sub 2/ 120 micro g/100 gm bodyweight two times therapeutic dose for 10 days (from day 8-18 of pregnancy). Each animal was weighted on day 1, day 8 and day 18 of pregnancy. Abortion resulted on day 18th of pregnancy. Each group of pregnant animals were sacrificed on day 18 of gestation by over dose of either anaesthesia, abdomen opened, uterus and both cornua containing conceptus identified, removed, there weight recorded, crown rump length was measured and was compared with similar value of control animals. The results were statistically analysed to find out the significance. Results: The ciprofloxacin induces a mordanting effect as obviated by increased basophilia. Our study reveals that ciprofloxacin administered in maternal, decreased maternal body weight to 38.4+-0.9 gm. However simultaneous ZnCl/sub 2/ maintained the body weight to 41.4+-0.7 gm, while ZnCl/sub 2/ increased the body weight to 46.5+-2.25 gm. The body weight and Crown Rump length (CR Length) in conceptus decreased by 4.52+-0.10 gm and 3.06+-0.09 Cm respectively. That ciprofloxacin and ZnCl/sub 2/ administration maintained the body weight and CR length by 5.46+-0.09 gm and 3.79+-0.13 Cm respectively. That ZnCl/sub 2/ administration increased the body weight and CR length by 6.71+-0.05 gm and 4.15+-0.08 Cm respectively. Conclusion: Prenatal administration

  2. Proteomic analysis of young leaves at three developmental stages in an albino tea cultivar

    Directory of Open Access Journals (Sweden)

    Li Juan

    2011-08-01

    Full Text Available Abstract Background White leaf No.1 is a typical albino tea cultivar grown in China and it has received increased attention in recent years due to the fact that white leaves containing a high level of amino acids, which are very important components affecting the quality of tea drink. According to the color of its leaves, the development of this tea cultivar is divided into three stages: the pre-albinistic stage, the albinistic stage and the regreening stage. To understand the intricate mechanism of periodic albinism, a comparative proteomic approach based on two-dimensional electrophoresis (2-DE and mass spectrometry was adopted first time to identify proteins that changed in abundance during the three developmental periods. Results The 2-DE results showed that the expression level of 61 protein spots varied markedly during the three developmental stages. To analyze the functions of the significantly differentially expressed protein spots, 30 spots were excised from gels and analyzed by matrix-assisted laser desorption ionization-time of flight-tandem mass spectrometry. Of these, 26 spots were successfully identified. All identified protein spots were involved in metabolism of carbon, nitrogen and sulfur, photosynthesis, protein processing, stress defense and RNA processing, indicating these physiological processes may play crucial roles in the periodic albinism. Quantitative real-time RT-PCR analysis was used to assess the transcriptional level of differentially expressed proteins. In addition, the ultrastructural studies revealed that the etioplast-chloroplast transition in the leaf cell of White leaf No. 1 was inhibited and the grana in the chloroplast was destroyed at the albinistic stage. Conclusions In this work, the proteomic analysis revealed that some proteins may have important roles in the molecular events involved in periodic albinism of White leaf No. 1 and identificated many attractive candidates for further investigation. In

  3. Protection of radiation-induced DNA damage in albino rats by Zingiber Montanum extract

    International Nuclear Information System (INIS)

    The tropical ginger, Zingiber montanum (J. König) A. Dietr, has potentials in scavenging free radicals and affording protection from radiation-induced chromosomal aberrations. The present investigation aims at determining antioxidant and radioprotective properties of the rhizome extract. Sulphur free radical, DPPH and superoxide scavenging assays were carried out for assessing antioxidant activities. Radiation-induced (500 cGy) DNA damage in pBR322 in vitro could be significantly reduced upto 71% (P < 0.05) by treatment with 60% ethanol extract (20 μg). Acute toxicity of the 60% ethanol extract was determined and suitable injectable dose was selected for intra-peritoneal administration in albino rats (Rattus norvegicus). The LD50 of extract calculated for 72 hrs was found to be 2.9 g/kg, and maximum tolerated dose (MTD) of rhizome extract was 1.3 g/kg. Rhizome extract (0.5 g/kg) in 60% ethanol was intra-peritoneally injected to albino rats and exposed to 100, 300 and 500 cGy. Radioprotective effect of the extract was determined by alkaline single cell comet assay. Significant reduction (P < 0.05) of comet DNA (68%) and length (61%)in rat bone marrow cells was observed at a radiation dose of 500 cGy. The results demonstrate that tropical ginger possess free radical scavenging properties and can protect bone marrow cells from radiation-induced DNA damages. The results on radiation induced DNA damage using plasmid pBR322 DNA obviously justify that the extract at a low dose can protect DNA from undergoing strand breakage due to gamma radiation exposure. Versatility of Zingiber montanum in different chemical assays in terms of its radical scavenging potential shows that this non-conventional food plant as a lot of potential in maintaining human health through dietary supplementation as nutraceutical. This candidate plant also can possibly be a promising candidate in clinical radiotherapy perhaps as a substitute of or the well-know radioprotector amifostine. (author)

  4. Vertebral muscles of the back and tail of the albino rat (Rattus norvegicus albinus).

    Science.gov (United States)

    Brink, E E; Pfaff, D W

    1980-01-01

    The dorsal and ventral vertebral muscles of the back and the tail of the albino Norway rat are described and discussed. These muscles were analyzed because they are undoubtably used during the sexual posturing, lordosis, of the female rat, as well as participating in a variety of other behaviors. The muscles are described by region (thoracic-lumbar or sacrocaudal), and the classifications of Vallois are followed where possible. Of the epaxial (dorsal) muscles, the three longitudinal systems of muscles, the transversospinalis, the longissimus, and the iliocostalis systems, can be identified in the albino rat. Muscles of the transversospinalis system are fused in the lumbar region, distinct and specialized in the thoracic region, and form the tail muscle extensor caudae medialis caudally. The iliocostalis system of the lumbar region is fused with one component of the lumbar longissimus system to form lateral longissimus. Anteriorly, iliocostalis thoracis and cervicis represent the iliocostalis system. The lumbar longissimus system is represented by the longissimus component of lateral longissimus, medial longissimus, and a short-fiber component. Longissimus dorsi is the anterior continuation of the longissimus portion of the lateral longissimus. The short-fiber component also continues into the thoracic region, where it becomes difficult to separate out from longissimus dorsi. Medial longissimus represents the excursion into the lumbar region of the long, tendinous, tailbase-tail muscle, longissimus caudae; the caudal portion of this muscle is extensor caudae lateralis. The remaining dorsal muscle described is the tail muscle, abductor caudae dorsalis. The hyposomal (ventral) muscles described are quadratus lumborum and the intertransversarii, present in the lumbar region; the muslces iliococcygeus, pubococcygeus and coccygeus which arise from the medial face of the pelvis and insert onto the proximal tail; the long, tendinous, tail muscles, flexor caudae brevis and

  5. Microscopic Studies Of The Effect Of Some Food Additives On The Kidney Of Albino Rat

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    Abd El-Tawab M. Ismail - Ashraf M.Moustafa

    2003-09-01

    Full Text Available Recently the use of synthetic food coloring additives was increased and the levels of human exposure to such agents are very broad, thus feeding over long periods may continually possess potential hazards to the human health. Also most of the food colors tested in the conventional toxicity experiments showed toxic effects at very high level of intake i.e. 1-5 % in the diet. The aim of this study was to evaluate the histological and histochemical effects of some of these substances (Sodium nitrate and sunset yellow on the liver of adult albino rats. The study included three main parts: A. Histological studies on the liver under the effect of (Sodium nitrate and sunset yellow substances. Using paraffin sections, which were stained with Hx & Eosin, Masson Trichrome B. Evaluation of histochemical activity of both alkaline phosphates enzyme and succinic dehydrogenase enzymes on the renal tissue. C. Statistical evaluation using image analyzer to detect glomerular area, area percentage of collagen fibers distribution and optical density of both alkaline phosphatase enzyme activity in glomerulus and succinic dehydrogenase enzyme activity in renal tubules. Seventy adult male albino rats were used. Nitrate and sunset yellow were given orally through a gastric tube in dose of 1 mg / kg / b.w. daily. The animals were classified into seven groups. 1. Group I (Control group 2. Group II: The animals were given sodium nitrate in a dose of 1mg/kg/bwt for one month. 3. Group III: The animals were given sun set yellow in a dose of 1mg/kg/bwt/day for one month. 4. Group IV: The animals were given sodium nitrate and sunset yellow for one month in a dose of 1mg/kg/bwt/for each drug in a separate manner. 5. Group V: The animals were given sodium nitrate similar to the previous dose as group II for one month and left 2 weeks without oral intubations. 6. Group VI: The animals were given sun set yellow No 6 in a dose and route of administrations as group III for one

  6. THE USE OF CASSAVA ROOT MEAL AS A PARTIAL REPLACEMENT FOR CORN IN DIETS FOR ALBINO RATS

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    Thomas Nii NARKU NORTEY

    2016-07-01

    Full Text Available The experiment was carried out to determine if partial replacement of maize with cassava root meal (CRM in diets for albino rats will have an effect on performance, organ characteristics and blood parameters. Twenty five Sprague Dawley albino rats (F344 strain, initial body weight (216 ± 8g were randomly assigned to five treatments (T1 to T5 in a completely randomized (CRD arrangement. T1 was the control and contained zero CRM. T2 and T3 contained 30% CRM, while T4 and T5 contained 45% CRM. These levels of inclusion represented 50 and 75% replacement of corn in the diets respectively. T2 and T4 had 0.15% methionine (Met while T3 and T5 had 0.3% Met. The rats were each fed a single diet for 28d. Average daily feed intake (ADFI of rats on T1 was lower (P 0.05 in average daily gain (ADG and feed conversion efficiency (FCE. Similarly there were no differences (P>0.05 in carcass, viscera and other internal organ weights. Results of this trial indicate that albino rats can tolerate diets with added CRM (45% of the diet with no adverse effects on growth and internal organ characteristics. Future work will need to look at the possibility of using CRM at similar or higher levels in diets for growing pigs.

  7. Distribution and ultrastructure of pigment cells in the skins of normal and albino adult turbot, Scophthalmus Maximus

    Institute of Scientific and Technical Information of China (English)

    GUO Huarong; HUANG Bing; QI Fei; ZHANG Shicui

    2007-01-01

    The distribution and ultrastructure of pigment cells in skins of normal and albino adult turbots were examined with transmission electron microscopy (TEM). Three types of pigment cells of melanophore, iridophore and xanthophore have been recognized in adult turbot skins. The skin color depends mainly on the amount and distribution of melanophore and iridophore, as xanthophore is quite rare. No pigment cells can be found in the epidermis of the skins. In the pigmented ocular skin of the turbot, melanophore and iridophore are usually co-localized in the dermis. This is quite different from the distribution in larvae skin. In albino and white blind skins of adult turbots, however, only iridophore monolayer still exists, while the melanophore monolayer disappears. This cytological evidence explains why the albino adult turbot, unlike its larvae, could never resume its body color no matter what environmental and nutritional conditions were provided. Endocytosis is quite active in the cellular membrane of the iridophore. This might be related to the formation of reflective platelet and stability of the iridophore.

  8. Entrevista con Juan Marichal.

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    - Consejo de Redacción

    1997-01-01

    Full Text Available Juan Marichal nació en Santa Cruz de Tenerife, en 1922, en el seno de una familia ligada al partido republicano insular. Muy joven, en 1935, se trasladó a Madrid, ciudad en la que vive el estallido de la guerra civil. En 1937, pasa a Valencia y luego a Barcelona; tras su exilio en 1938, prosigue sus estudios secundarios en un liceo de París, concluyéndolos en Casablanca. En 1941 emigra a México, formándose en la UNAM: fue alumno de los exiliados José Gaos y Joaquín Xirau así como del mexicano Edmundo O 'Gorman. Luego, becado en Princeton desde 1946, lo fue de América Castro, donde preparó una tesis sobre Feijoo. Apoyado en las vastas perspectivas de sus maestros, fue orientándose hada nuestra historia intelectual, desde el siglo XV hasta hoy. Su carrera profesional se ha desarrollado en los Estados Unidos (coincidiendo con Amado Alonso y con Ferrater Mora: ha sido profesor de estudios hispánicos en la Universidad de Harvard, desde 1948 hasta 1988, año en que se jubiló voluntariamente como numerario (aunque había permanecido en el Bryn Mawr College, entre 1953 y 1957. A este trabajo se suman, con todo, sus conferencias en América Latina y en España. Ha colaborado en las revistas más importantes, en este campo, de México, Nueva York, Puerto Rico, La Habana, Buenos Aires o París así como de las españolas, desde los sesenta. Juan Marichal -hoy, miembro de la Junta Directiva de los Amigos de la Residencia de Estudiantes, director del Boletín de la Institución Libre de Enseñanza y asociado al Instituto Universitario Ortega y Gasset-, reside en España desde otoño de 1989: se considera a sí mismo «voluntario en Madrid», como había dicho Alfonso Reyes en su estancia madrileña (1914-1924.

  9. Los cuadrados mágicos matemáticos en al-Andalus. El tratado de Azarquiel

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    Comes, Mercè

    2009-06-01

    Full Text Available This paper focuses on the presence of mathematical magic squares in al-Andalus. After an introductory review on the history of magic squares, the problem of their origins and their development in Eastern Islam, the methods of construction of the talismanic squares appearing in two manuscripts of Azarquiel’s treatise, the only one on this subject known in al-Andalus, as well as their reception in Europe are examined.

    El artículo estudia la presencia de los cuadrados mágicos matemáticos en al-Andalus. Después de un repaso introductorio a la historia de dichos cuadrados mágicos, al problema de su origen y a su desarrollo en el oriente islámico, se examinan los métodos de construcción de los cuadrados talismánicos que aparecen en dos manuscritos del tratado de Azarquiel, el único sobre este tema conocido en al-Andalus, así como su recepción en Europa.

  10. Tratamiento con caspofungina de endocarditis por Candida tropicalis resistente a fluconazol Treatment with caspofungin of Candida tropicalis endocarditis resistant to fluconazol

    Directory of Open Access Journals (Sweden)

    Marcelo del Castillo

    2004-04-01

    Full Text Available Las endocarditis causadas por hongos, (Candida en particular, requieren tratamiento médico-quirúrgico, siendo la anfotericina B la droga de elección. Caspofungina es una equinocandina con gran actividad sobre Candida y Aspergillus. Se presenta un paciente con una endocarditis por Candida tropicalis resistente a fluconazol tratado con caspofungina bajo un esquema de salvataje, luego de haber presentado efectos adversos por anfotericina B. El paciente tuvo respuesta microbiológica.Fungal endocarditis, in particular due to Candida species, requires medical and surgical treatment and amphotericin B is the drug of choice. Caspofungin is an echinocandin very effective against Candida and Aspergillus. We present a patient with Candida tropicalis endocarditis, fluconazol resistant, treated with caspofungin, on a compassional basis as a result of adverse effects with amphotericin B. The patient had a microbiological response.

  11. Simulación de ensayos triaxiales cíclicos con presión de confinamiento constante y variable empleando ecuaciones empíricas

    Directory of Open Access Journals (Sweden)

    Hugo Alexander Rondón Quintana

    2009-01-01

    para intentar predecir la acumulación de las deformaciones permanentes que experimentan materiales granulares no tratados (GNT en ensayos triaxiales cíclicos con presión de confinamiento constante (PCC y variable (PCV. Con base en el análisis de dichas ecuaciones, se escogieron las más utilizadas en el mundo con el fin de simular el comportamiento que experimentó un GNT en ensayos tipo PCC y PCV. Las simulaciones realizadas demuestran que la mayor parte de las ecuaciones empíricas que se utilizan para predecir la acumulación de la deformación permanente de un material granular bajo carga cíclica no pueden reproducir su comportamiento en ensayos PCC y PCV. Adicionalmente, los parámetros que emplean dichas ecuaciones no son constantes del material.

  12. Los impactos del Tratado de Libre Comercio de América del Norte en la producción de frijol de Zacatecas

    Directory of Open Access Journals (Sweden)

    Elivier Reyes Rivas

    2007-01-01

    Full Text Available La apertura comercial total, prevista en el Tratado de Libre Comercio de América del Norte (TLCAN para 2008, puede afectar la agricultura y el empleo rural de Zacatecas, particularmente la producción de frijol, donde la entidad ocupa el primer lugar como productor nacional. Dicha leguminosa ocupa 57 por ciento del área sembrada en el estado y emplea a cerca de 70 mil personas. Al revisar los términos comerciales pactados, datos estadísticos y fuentes primarias, se concluye que la competitividad que genere la apertura comercial puede precipitar el abandono de los cultivos y el deterioro de las condiciones de vida de miles de agricultores. El gobierno mexicano debería reevaluar los términos del tratado para impulsar la producción agrícola y establecer políticas públicas nuevas generadoras de empleo.

  13. Los tratados y el jardín renacentista en Italia. Principios, metodologías y técnicas

    OpenAIRE

    Taffuri, Tullio

    2013-01-01

    La tesis destaca la influencia que ejerció la teoría, las técnicas y la metodología de proyecto de los principales tratados de la época renacentista en la concepción, diseño y realización de algunos de los más importantes jardines de la época. Los tratados de Vitruvio, Alberti, Filarete, Di Giorgio, Serlio, Palladio, Colonna y Del Riccio establecen una nueva estética y una nueva visión del mundo, basadas en la geometría elemental y en los números simples. En la Grecia antigua, Platón y Pitágo...

  14. Entrevista con Geoffrey Lloyd.

    OpenAIRE

    Fernando Colina Pérez; Mauricio Jalón

    2008-01-01

    Helenista y también sinólogo de relieve internacional, Geoffrey E. R. Lloyd nació en Londres (1933), de padres galeses. Es un gran historiador de la ciencia y del pensamiento griegos. En 1940 fue evacuado de Londres con su madre. Sus estudios significativos comenzaron, tras algún rodeo, en el King’s College donde estudiaba su hermano. Éste sería, como su padre, médico, y él mismo dudó en estudiar esa profesión, que late en sus libros. Pero un profesor de clásicas como John Raven –que redactó,...

  15. Entrevista con Georges Duby.

    Directory of Open Access Journals (Sweden)

    - Consejo de Redacción

    1994-01-01

    Full Text Available Duby, heredero de dos grandes historiadores como Marc Bloch y Lucien Febvre, es uno de los más importantes medievalistas europeos. Fue, y sigue siendo, un motor de la importante reforma en la historia producida desde los sesenta. En sus primeros trabajos se acusa la recepción de las ideas económicas y geográficas de la mejor historiografía. Su riguroso estudio sobre la base material de la Edad Media, le permitirá luego irrumpir en la historia de las mentalidades, analizando, como decía Febvre, el utillaje mental (vocabulario, sintaxis, lugares comunes, cuadros lógicos, etc. del Medioevo. Así, el ejemplo de Mauss y LéviStrauss le anima a trabajar sobre el matrimonio, la sexualidad y ciertos sistemas del pensamiento: el primero, con su defensa de los hechos sociales totales, y el segundo, que buscaba las dimensiones simbólicas de lo social, le impulsan a trabajar sobre la ideología entendida no como mero reflejo de la situación material sino como «proyecto de acción sobre lo vivido». A su obra individual, atenta a los impulsos culturales más vivos, se suma su empuje decisivo en la realización de proyectos colectivos como la Historia de la vida privada o la Historia de las mujeres. Prácticamente, han sido traducidos todos sus libros al castellano, y han podido verse en España asimismo varios de sus programas televisivos (ha sido presidente de la SEPT, cadena de televisión cultural fundada en 1985. La amplitud de sus intereses intelectuales, transmitidos en su obra con un lenguaje a la vez muy claro y bellamente elaborado, se hace palpable también en este diálogo.

  16. Realización y corrección automática de exámenes con hoja de cálculo

    Directory of Open Access Journals (Sweden)

    Sánchez García, Juan Francisco

    2007-01-01

    Full Text Available La forma habitual de realizar exámenes de tipo test es mediante formularios en papel que posteriormente son tratados con un escáner y un software específico que facilita la corrección así como la emisión de informes y la exportación de datos a aplicaciones de hoja de cálculo. En las asignaturas de informática de gestión llama la atención que en algunos casos se hace evaluación de términos informáticos y utilización de aplicaciones informáticas sobre papel, cuando el hacerlo directamente sobre el ordenador permitiría además comprobar los conocimientos prácticos del alumno.Con la idea de facilitar al alumno la cumplimentación de este tipo de exámenes hemos desarrollado una metodología propia utilizando la hoja de cálculo Microsoft Excel. De esta forma el formulario de examen se sustituye por un fichero de hoja de cálculo que posteriormente será tratado para obtener los resultados contenido en el mismo y facilitar su corrección, la cual también se efectuará con la propia hoja de cálculo, utilizando programación en Visual Basic para Aplicaciones (VBA.

  17. Análisis de regresión con datos imprecisos: Un nuevo enfoque que utiliza distancias difusas y sus aplicaciones

    OpenAIRE

    Aguilar-Peña, María-de-la-Concepción

    2015-01-01

    [ES] El análisis de regresión es una herramienta estadística potente con muchas aplicaciones en diferentes áreas. Este problema en un entorno difuso ha sido tratado en la literatura desde diferentes puntos de vista y teniendo en cuenta una variedad de datos de entrada/salida (reales o difusos). En esta memoria se presenta una nueva metodología basada en una familia de medidas de distancia difusas entre números difusos arbitrarios que se define utilizando algunas de las características posibi...

  18. Seguridad y eficacia de un concentrado de complejo protrombínico en pacientes con coagulopatía y hemorragia

    OpenAIRE

    N. Martínez-Calle; M. Marcos-Jubilar; Alfonso, A.; M Hernández; Hidalgo, F.; R. Lecumberri; J.A. Páramo

    2014-01-01

    Fundamento: Los concentrados de factores del complejo protrombínico (CCP) están indicados para reversión del efecto de antagonistas de vitamina K (AVK). Recientemente se han utilizado en el manejo de la coagulopatía de la hemorragia masiva. El objetivo del presente trabajo es evaluar la seguridad y eficacia del CCP en dos situaciones clínicas, para reversión de AVK y manejo integral de la hemorragia masiva. Material y métodos: Revisión retrospectiva de los casos tratados con CCP entre enero d...

  19. La moneda castellana en los manuales de mercaderías y tratados de aritmética italianos bajomedievales (siglos XIII-XV)

    OpenAIRE

    González Arévalo, Raúl

    2007-01-01

    El presente artículo analiza el conocimiento sobre la moneda y el sistema monetario vigentes en Castilla en la Baja Edad Media en los manuales de mercadería y los tratados de aritmética italianos de los siglos XIII al XV. The present paper analyzes the knowledge of money and money system in Castile in the Late Middle Ages in the Italian pratiche di mercatura and treaties of Arithmetics from the XIIIth to XVth Centuries.

  20. Effect of Chronic Use of Recreational Drugs on the Sperm Count in Albino Mice

    Directory of Open Access Journals (Sweden)

    Sravonee Purkayastha

    2014-05-01

    Full Text Available Chronic use of various recreational drugs is leading to drug abuse which is increasingly developed in the modern society among the various populations throughout the world. The present study was conducted to investigate the impact of a few recreational drugs viz., anabolic androgenic steroids (AAS, alcohol and nicotine on male fertility status which was assessed by measuring sperm count in male albino mice. Semen samples were collected from normal, AAS-treated, alcohol-treated and nicotine-treated mice and the sperm count (in millions/ml semen was assessed at regular intervals i.e. on 10th, 20th, 30th, 45th,60th,75th and 90th day of treatment during the experimental period of 90 days. The results showed a significant decrease in the sperm count in AAS-treated, nicotine-treated (p<0.01 and alcohol-treated mice (p<0.05 compared to that of the normal mice. The present study clearly indicates suppression of sperm count on AAS, alcohol and nicotine treatment which may be one of the contributing factors in male infertility.

  1. Antiovulatory and estrogenic activity of Plumbago rosea leaves in female albino rats

    Directory of Open Access Journals (Sweden)

    Sheeja E

    2009-01-01

    Full Text Available Objective : To evaluate the effect of petroleum ether (60-80, chloroform, acetone, ethanol and aqueous extracts of Plumbago rosea leaves on the estrous cycle and to identify the estrogenic activity of active acetone and ethanol extracts in female albino rats. Methods : Plant extracts were tested for their effect on the estrous cycle at two dose levels: 200 and 400 mg/kg, respectively. The effective acetone and ethanol extracts were further studied on estrogenic activity in rats. Histological studies of the uterus were carried out to confirm their estrogenic activity. Results : The acetone and ethanol extracts were most effective in interrupting the normal estrous cycle of the rats (P< 0.05, < 0.01, < 0.001. These later exhibited prolonged diestrous stage of the estrous cycle with consequent temporary inhibition of ovulation. The antiovulatory activity was reversible on discontinuation of treatment. Both the extracts showed significant estrogenic and antiestrogenic activity. Conclusion : The acetone and ethanolic extracts of P. rosea leaves have an antifertility activity.

  2. Restoring lens capsule integrity enhances lens regeneration in New Zealand albino rabbits and cats.

    Science.gov (United States)

    Gwon, A; Gruber, L J; Mantras, C

    1993-11-01

    In studies conducted by numerous investigators for 150 years, lenses regenerated following endocapsular lens extraction in New Zealand albino rabbits have been irregular in shape, appearing primarily doughnut-shaped as a result of lack of lens growth at the site of the anterior capsulotomy and its adhesion to the posterior capsule. In the present study, we restored the lens capsule integrity by inserting a collagen patch at the time of surgery to seal the anterior capsulotomy and to improve the shape and structure of the regenerated lenses. We then filled the capsule bag with air to prevent adhesions between the anterior and posterior capsule and maintain capsule tautness and shape. Lens regeneration was first noted as early as one to two weeks. Regenerated lens filled approximately 50% of the capsule bag at two weeks and 100% by five weeks. Subsequent growth was in the anterior-posterior direction and measured by A-scan biometry. Lens thickness increased by 0.3 mm per month. The regenerated lenses were spherical with normal cortical structure and a nuclear opacity. In conclusion, restoration of lens capsular integrity with a collagen patch following endocapsular lens extraction enhanced the shape, structure, and growth rate of the regenerated lenses. In addition, lens regeneration was shown to occur in two cats.

  3. Neuroprotective effect of grape seed extract against cadmium toxicity in male albino rats.

    Science.gov (United States)

    El-Tarras, Adel El-Sayed; Attia, Hossam Fouad; Soliman, Mohammed Mohamed; El Awady, Mohammed Abdelhamid; Amin, Adnan Abelghani

    2016-09-01

    Cadmium toxicity can disturb brain chemistry leading to depression, anxiety, and weakened immunity. Cadmium disturbs the neurotransmitter dopamine, resulting in low energy, lack of motivation, and depression, which are predisposing factors for violence. The purpose of this study was to evaluate the ameliorative effect of grape seed extract (GSE) on the brain of 40 male albino rats after exposure to cadmium chloride (Cd) toxicity. The rats were separated into either the control group, the Cd group, the GSE group, or the GSE and Cd mixture (treated) group. The cerebrum showed evidence of degeneration of some nerve fibers and cells. Fibrosis, vacuolations, and congestion in the blood vessels were demonstrated. Satelletosis was located in the capsular cells. Immunohistochemical expression of Bax was strongly positive in the Cd group and decreased in the treated group. These histopathological changes were decreased in the brain tissue of the treated group, but a few blood vessels still had evidence of congestion. Cadmium administration increased the level of MDA and decreased MAO-A, acetylcholinesterase, and glutathione reductase (GR), while the treatment with GSE affected the alterations in these parameters. In addition, cadmium downregulated the mRNA expression levels of GST and GPx, while GSE treatment normalized the transcript levels. The expression of both dopamine and 5-hydroxytryptamine transporter was downregulated in the rats administered cadmium and the addition of GSE normalized the expression of these aggression associated genes. PMID:27271977

  4. Antioxidative Effect of Trichosanthes tricuspidata Root Extract on Sildenafil Induced Migraine in Albino Mice

    Directory of Open Access Journals (Sweden)

    P Nithiya

    2009-01-01

    Full Text Available Migraine is considered a neurovascular disease involving the dilatation of cerebral arteries. Because of their dual role in modulating neuronal and vascular events, neuropeptides have been implied to be of importance in migraine pathophysiology. It is a highly prevalent disorder which manifests clinically as moderate to severe or severe headache attacks with frequent frontotemporal unilateral location and associated symptoms. The disability of migraine results in considerable economic and social losses .Nitric oxide, a short lived vasodilator and weak oxygen radical has been implicated in the genesis of migraine headaches. Hence the role of all enzymic and non enzymic antioxidants becomes in evitable in the treatment of migraine. Trichosanthes tricuspidata′s (red apple gourd antioxidant effect was tested over Sildenafil induced migraine in female albino mice. The levels of antioxidant enzymes such as super oxide dismutase (SOD, lipid peroxidase(LPO, catalase(CAT and glutahione peroxidase(GPx were more promising in the treatment group fed with the root extract of Trichosanthes tricuspidata.

  5. Autoradiographic localization of tritiated dihydrotestosterone in the flank organ of the albino hamster

    International Nuclear Information System (INIS)

    In the hamster flank organ, the growth of hair and growth of sebaceous glands are androgen-dependent functions. Although dihydrotestosterone (DHT) is known to be a potent stimulator of flank organ growth, there is no information about localization of DHT receptor sites in this organ. The purpose of this study was to use steroid autoradiography to localize DHT receptors in the hamster flank organ. Because steroid hormones are functional when translocated to nuclear receptors, nuclear localization by autoradiography defines receptor sites. In order to be able to visualize autoradiographic grains from radiolabeled androgens around hair follicles, albino hamsters were studied to avoid confusion between the grains and pigment granules which are abundant in the more common Golden Syrian hamster. Mature male hamsters castrated 24 hours earlier were given tritium-labeled dihydrotestosterone ( [3H]DHT). Using the technique of thaw-mount steroid autoradiography, 4-micron unfixed frozen sections were mounted in the dark onto emulsion-coated glass slides and allowed to develop for 4-6 months. [3H]DHT was found to be concentrated over sebocyte nuclei. The label was present peripherally as well as in differentiating sebocytes. There was no nuclear localization of [3H]DHT in animals pretreated with excessive quantities of unlabeled DHT. Steroid metabolites of [3H] DHT were assessed by thin-layer chromatography in paired tissue samples. Most of the label remained with DHT. Uptake was inhibited in the flank organ of hamsters pretreated with unlabeled DHT

  6. Protective Role Of Fresh Pomegranate Against Oxidative Damage In Whole Body Gamma Irradiated Male Albino Rats

    International Nuclear Information System (INIS)

    Twenty four male albino rats, body weight 100-130 g, were used to evaluate the protective role of fresh pomegranate fruit intake for 30 days on the damage induced by single dose of 6 Gy whole body gamma irradiation. The rats were randomly and equally divided into four groups: group (1): control, group (2): irradiated with 6 Gy, group (3): pomegranate for 30 days and group (4): pomegranate for 30 days followed by 6 Gy whole body irradiation. At the end of the experiment, all rats were sacrificed after 12 hours fasting then sera were separated for the determination of sugar, total antioxidant, lipid profile and liver and kidney functions. Results showed that gamma radiation caused significant decline (P<0.05) in serum total antioxidant, total protein, albumin, HDL-C and blood glucose with significant elevation (P<0.05) in other hepato-renal markers in addition to serum total cholesterol, triglycerides and LDL-C. These changes were significantly attenuated in irradiated animals pre-treated with whole fresh pomegranate fruit leading to the conclusion that pre-intake of pomegranate fruit had a radio- protective effect. This protection of this whole fruit may be due to the increased total antioxidant level leading to free radical scavenging

  7. Evaluation of the aphrodisiac activity of Tribulus terrestris Linn. in sexually sluggish male albino rats

    Directory of Open Access Journals (Sweden)

    Surender Singh

    2012-01-01

    Full Text Available Objectives: To study the effect of acute and repeated dose administration of lyophilized aqueous extract of the dried fruits of Tribulus terrestris (LAET on sexual function in sexually sluggish male albino rats. Materials and Methods: Aphrodisiac activity of the test drug was evaluated in terms of exhibited sexual behavior. In order to assess the effect of chronic T. terrestris exposure on the hypothalamus--pituitary--gonadal axis, testosterone level estimation and sperm count were carried out. Twenty-eight-day oral toxicity studies were carried out to evaluate the long-term effects of the LAET administration on different body systems. Results: A dose-dependent improvement in sexual behavior was observed with the LAET treatment as characterized by an increase in mount frequency, intromission frequency, and penile erection index, as well as a decrease in mount latency, intromission latency, and ejaculatory latency. The enhancement of sexual behavior was more prominent on chronic administration of LAET. Chronic administration of LAET produced a significant increase in serum testosterone levels with no significant effect on the sperm count. No overt body system dysfunctions were observed in 28-day oral toxicity study. Conclusions: Findings of the present study validate the traditional use of T. terrestris as a sexual enhancer in the management of sexual dysfunction in males.

  8. Hazardous effects of fried potato chips on the development of retina in albino rats

    Institute of Scientific and Technical Information of China (English)

    Hassan I El-Sayyad; Saber A Sakr; Gamal M Badawy; Hanaa S Afify

    2011-01-01

    Objective: To evaluate the hazardous effects of fried potato chips upon the retina of two developmental stages of the albino rats aged 7 and 14 days from parturition. Methods: Pregnant rats were arranged into two groups: control pregnant rats and consequently their delivered newborns until reaching 7 and 14 days old from parturition and fried potato chips group in which pregnant rats at the 6th day of gestation maintained on diet formed of fried potato chips supplied from the market mixed with standard diet at a concentration of 50% per each till 7 and 14 post-partum. Three fold integrated approaches were adopted, namely, histological, ultrastructural and proteomic analysis. Results: Histological examination of the retina of the experimental offsprings revealed many histopathological changes, including massive degeneration, vacuolization and cell loss in the ganglion cell layer, as well as general reduction in retinal size. At the ultrastructural level, the retina of experimental offsprings exhibited number of deformities, including ill differentiated and degenerated nuclear layer, malformed and vacuolated pigment epithelium with vesiculated and fragmented rough endoplasmic reticulum, degenerated outer segment of photoreceptors, as well as swollen choriocapillaris and loss of neuronal cells. Proteomic analysis of retina of the two experimental developmental stages showed variations in the expressed proteins as a result of intoxication which illustrated the adverse toxic effects of fried potato chips upon the retina. Conclusions: It can be concluded that the effect of fried potato chips on the development of retina in rats may be due to the presence of acrylamide or its metabolite.

  9. Effect of Camel's Milk on Cisplatin-Induced Nephrotoxicity in Swiss Albino Mice

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    Mohamed M.E. Afifi

    2010-01-01

    Full Text Available Problem statement: Nephrotoxicity is a major complication and a dose limiting factor for cisplatin therapy. Cisplatin mediated nephrotoxicity is remarkably documented by reactive oxygen species. Camel's milk has good nutritive value, antigenotoxic and anticytotoxic effects. The aim of the present study was to assess the protective effect of camel's milk against Cisplatin-induced renal oxidative stress in mice. Approach: Forty mal Swiss albino mice were randomly divided into four groups (n = 10. Group I, control group. Group II was received cisplatin (12 mg kg-1 for 5 alternate days. Group III was received camel's milk (33 mL kg-1 for consecutive 30 days. Group IV was received camel's milk (33 mL kg-1 for consecutive 30 days before administration of Cisplatin. Results: Cisplatin-induced oxidative stress was indicated by increased level of tissue Malondialdehyde (MDA, serum creatinine and urea, decreased the concentration of reduced Glutathione (GSH, Vitamin C (Vit. C and Vitamin E (Vit. E and decreased both activities and gene expression of Superoxid Dismutase (SOD, Catalase (CAT, Glutathione Raductase (GR and Glutathione Peroxidase (GPx. Camel's milk reduced these biochemical changes and counteracted the deleterious effects of cisplatin Conclusion: The present study demonstrated the renoprotective potential of camel's milk against cisplatin-induced oxidative stress and renal dysfunction in mice. Hence, camel's milk has a potential to be used as therapeutic adjuvant in cisplatin nephrotoxicity.

  10. Biochemical Effects Of Ribavirin (Antiviral And Ddb (Hepato Protective Drugs In Albino Rats

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    Soliman S. Ibrahim, Amr Shalaby and Mahmoud Rabeh

    2005-09-01

    Full Text Available The present investigation has been designed to through spot light on the efficiency of these two drugs in treatment of hepatitis patients. Cortisol, antigliadin (1gG , total protein (TP albumin (ALB , Iron (Fe , alanine aminotransferase (ALT , aspartic aminotransferase (AST and alkaline phosphatase (ALP were determined in serum of normal mature male and female albino rats that injected intraperitoneally day after day with 1mg/kg body weight of each drug separately for 3 months. The cortisol level and ALP showed significant increase in each of ribavirin or DDB treated animals, while the IgG concentration in ribavirin treated animals increased significantly, but it is did not vary greatly from that of the control in DDB treated animals. On the other hand both ribavirin and DDB treated male and female rats showed significant decrease in the ALT in serum while serum AST elicited non significant decrease in each of ribavirin and DDB treated male and female. With respect to serum TP and ALB levels the result showed significant decrease in ribavirin and non significant decrease in DDB treated male and female rats. Furthermore, the serum Fe level in ribavirin treated male and female rats increased significantly but it is did not vary greatly from that of the control in DDB treated animal.

  11. Clastogenic Effects of Glyphosate in Bone Marrow Cells of Swiss Albino Mice

    International Nuclear Information System (INIS)

    Glyphosate (N-(phosphonomethyl) glycine, C3H8NO5P), a herbicide, used to control unwanted annual and perennial plants all over the world. Nevertheless, occupational and environmental exposure to pesticides can pose a threat to nontarget species including human beings. Therefore, in the present study, genotoxic effects of the herbicide glyphosate were analyzed by measuring chromosomal aberrations (CAs) and micronuclei (MN) in bone marrow cells of Swiss albino mice. A single dose of glyphosate was given intraperitoneally (i.p) to the animals at a concentration of 25 and 50 mg/kg b.wt. Animals of positive control group were injected i.p. benzo(a)pyrene (100 mg/kg b.wt., once only), whereas, animals of control (vehicle) group were injected i.p. dimethyl sulfoxide (0.2 mL). Animals from all the groups were sacrificed at sampling times of 24, 48, and 72 hours and their bone marrow was analyzed for cytogenetic and chromosomal damage. Glyphosate treatment significantly increases CAs and MN induction at both treatments and time compared with the vehicle control (P<.05). The cytotoxic effects of glyphosate were also evident, as observed by significant decrease in mitotic index (MI). The present results indicate that glyphosate is clastogenic and cytotoxic to mouse bone marrow.

  12. In vivo anticancer activity of vanillin, benzophenone and acetophenone thiosemicarbazones on Swiss albino mice

    Institute of Scientific and Technical Information of China (English)

    Sha Md. Shahan Shahriar; Shaikh M Mohsin Ali; Mele Jesmin; Md. Khairul Islam; Sarozit Mondal

    2014-01-01

    Objective: To study the anticancer activities of three schiff bases viz. vanillin thiosemicarbazone, benzophenone thiosemicarbazone and acetophenone thiosemicarbazone against Ehrlich ascites carcinoma (EAC) cells in Swiss albino mice. Methods: Synthesized compounds have administrated into the intraperitoneal cavity of the EAC inoculated mice at two doses. The anticancer activities have studied by monitoring the parameters such as cell growth inhibition, tumor weight measurement, survival time of EAC bearing mice as well as the changes in depleted hematological parameters due to tumorgenesis. All such data have been compared with those of a known standard drug bleomycin at the dose of 0.3 mg/kg (i.p.).Results:It has been found that these bases enhanced life span, reduced average tumor weight and inhibited tumor cell growth of EAC cell bearing mice remarkably. The results were similar in potency to those obtained with bleomycin. It was also found that the depleted hematological parameters (red blood count, white blood count and haemoglobin content) were found to be restored gradually towards normal within few weeks after ceasing the treatment.Conclusions:The compounds can be primarily considered more or less as potent anticancer agents.

  13. The acute lethal dose 50 (LD50) of caffeine in albino rats.

    Science.gov (United States)

    Adamson, Richard H

    2016-10-01

    An acute LD50 is a statistically derived amount of a substance that can be expected to cause death in 50% of the animals when given by a specified route as a single dose and the animals observed for a specified time period. Although conducting routine acute toxicity testing in rodents has been criticized, it can serve useful functions and also have practical implications. Material safety data sheets (MSDS) will reflect the acute toxicity of a substance and may require workers to wear protective gear, if appropriate, based on the LD50. There is no information in the scientific published literature which calculates a mean LD50 and standard deviation for caffeine administered orally to rats, using studies performed under good laboratory practice (GLP) or equivalent. This report does that and should be useful to manufacturers, packagers, transporters and regulators of this material. Using data from studies that are reproducible and reliable, the most accurate estimate of the acute LD50 of caffeine administered orally in male albino rats is hereby reported to be 367/mg/kg. PMID:27461039

  14. [EFFICACY OF A NEW MEBENDAZOLE FORMULATION FOR EXPERIMENTAL ECHINOCOCCUS GRANULOSUS LARVAL INVASION IN ALBINO MICE].

    Science.gov (United States)

    Kovalenko, F P; Kukhaleva, I V; Shkolyar, N A; Legonkov, Yu A; Musaev, G Kh; Bulanova, T E; Samochatova, E I

    2015-01-01

    The problem of echinococcosis has acquired special urgency in Russia in the last 10 years. The dramatically worse epidemiological situation of echinococcosis in the country is suggested by just frequent cases of cystic echinococcosis in the indigenous population of Moscow and its region, including children. Currently, albendazole that is less toxic than mebendazole remains the drug of choice, However, some authors note that E. granulosus larval cysts are moresusceptible to mebendazole than to albendazole. Both drugs mainly show parasitological activity and have no larvicidal effect particularly in larval alveococcosis. Analysis of the results of chemotherapy, with a group of benzimidazole carbamates for echinococcosis in 6 clinical centers from 5 European countries (Italy, Bulgaria, Romania, Greece, and Turkey) over the past 30 years showed that the evaluation of therapeutic effectiveness was overestimated; thus, 40% of all parasitic larval cysts that were considered dead became active again after, 2 years after the treatment. The original oil micronized mebendazole suspension tested by us in albino mice with late-stage larval cystic echinococcosis showed the properties of a highly effective and safe systemic larvicide that caused prompt death in the entire parasite population in the treated animals even in extreme hyperinvasion when the baseline parasite weight was greater than the host's one.

  15. Effect of Solanine on Arthritis Symptoms in Postmenopausal Female Albino Rats

    International Nuclear Information System (INIS)

    Solanine is a toxic compound produced in nightshades family as potato,tomato and eggplant when exposed to light.The current study was carried out on 18 female postmenopausal albino rats to investigate the effect of solanine on the symptoms of rheumatoid arthritis.Animals were classified into 3 groups feeding on balanced diet only (GI) or replaced by two third with small pieces of diseased potatoes for 2 and 4 weeks (GII,GIII) respectively . Serum levels of arthritic bio markers were investigated as the estimation of erythrocytes sedimentation rate ( ESR) , C-Reactive Protein (CRP), malondialdehyde (MDA),Tumor necrosis factor-α (TNF-α),Interleukin-6( IL-6) and Immunoglobulin G (IgG) were determined in all groups. There was a significant positive increase in the levels of ESR, CRP , MDA , TNF-α, IL-6 , and IgG among different groups depending on potatoes intake. There was positive correlation between the serum levels of CRP and TNF-α ,Il-6 and IgG.However, a non significantly positive correlation between serum level of CRP and the level of MDA was observed. The data of the present study showed that old age and postmenopausal suffering from arthritis and joint swollen must eliminat or avoid the nightshades plants to alleviate the joint pain and also decrease the destruction of the tissues

  16. [Comparative efficacy of albendazole and mebendazole oily suspensions in albino mice with experimental larval alveococcosis].

    Science.gov (United States)

    Kovalenko, F P; Kukhaleva, I V; Shkoliar, N A; Legon'kov, Iu A

    2013-01-01

    The comparative efficacy of albendazole and mebendazole oily suspensions (AOS and MOS) was studied in an experimental model of experimental larval alveococcosis in albino mice. The animals were intragastrically injected with the agents once daily for 40 days on day 35 after intraperitoneal inoculation with E. multilocularis acephalocysts. They were dissected 29 days after treatment termination (103 days following inoculation) and the rate of infestation and viability and the degree of maturity of developed alveococcosis larvocysts (AL) were determined. The AOS and MOS efficiency estimated by the mean mass of AL per animal was 83.3 and 98.1%, respectively; whereas the similar indicator calculated by one largest AL weight per animal found among all the animals in the compared groups was equal to 57.7 and 96.9%, respectively. Under the equal conditions of solubilization in vegetable oil, the biological activity and bioavailability of mebendazole were shown to increase to a much greater extent than those of albendazole. The findings suggest that the use of mebendazole is promising for designing new vegetable oil-based formulations of the agent. PMID:24003516

  17. [EFFICACY OF A NEW MEBENDAZOLE FORMULATION FOR EXPERIMENTAL ECHINOCOCCUS GRANULOSUS LARVAL INVASION IN ALBINO MICE].

    Science.gov (United States)

    Kovalenko, F P; Kukhaleva, I V; Shkolyar, N A; Legonkov, Yu A; Musaev, G Kh; Bulanova, T E; Samochatova, E I

    2015-01-01

    The problem of echinococcosis has acquired special urgency in Russia in the last 10 years. The dramatically worse epidemiological situation of echinococcosis in the country is suggested by just frequent cases of cystic echinococcosis in the indigenous population of Moscow and its region, including children. Currently, albendazole that is less toxic than mebendazole remains the drug of choice, However, some authors note that E. granulosus larval cysts are moresusceptible to mebendazole than to albendazole. Both drugs mainly show parasitological activity and have no larvicidal effect particularly in larval alveococcosis. Analysis of the results of chemotherapy, with a group of benzimidazole carbamates for echinococcosis in 6 clinical centers from 5 European countries (Italy, Bulgaria, Romania, Greece, and Turkey) over the past 30 years showed that the evaluation of therapeutic effectiveness was overestimated; thus, 40% of all parasitic larval cysts that were considered dead became active again after, 2 years after the treatment. The original oil micronized mebendazole suspension tested by us in albino mice with late-stage larval cystic echinococcosis showed the properties of a highly effective and safe systemic larvicide that caused prompt death in the entire parasite population in the treated animals even in extreme hyperinvasion when the baseline parasite weight was greater than the host's one. PMID:26827585

  18. Effect of ethanolic seed extract of Caesalpinia bonducella on fertility in pregnant female albino rats

    Institute of Scientific and Technical Information of China (English)

    Lilaram; R Nazeer Ahmed

    2013-01-01

    Objective: In the present study, an attempt has been made to investigate the effect of ethanolic seed extract of Caesalpinia bonducella (C. bonducella) on fertility in female Wistar albino rats. Methods: Pregnant rats were randomized into two groups containing eight animals in each group. Control group rats were orally administered with 1 mL/100 g b.wt of distilled water while rats in second group received 300 mg/kg of the seed extract from gestation day 1-7, once daily. The animals were sacrificed twenty four hours after the last dose on gestation day 12. Results:A significant reduction in implantation index and a contrasting significant increase in resorption index, pre-implantation and post-implantation loss was recorded in the seed extract treated rats. Progesterone level declined significantly in rats treated with seed extract. Ovary revealed degenerated corpora lutea in treated rats. The embryos were noticed with craniofacial deformities in extract treated group. Conclusions: The results obtained in this study suggest that the seeds of C. bonducella possess antifertility activity probably due to its antiprogesterogenic hormonal properties that can modulate the reproductive function of the experimental rats.

  19. Long-term exposure to incense smoke alters metabolism in Wistar albino rats.

    Science.gov (United States)

    Alokail, Majed S; Al-Daghri, Nasser M; Alarifi, Saud A; Draz, Hossam M; Hussain, Tajamul; Yakout, Sobhy M

    2011-03-01

    The burning of incense is an important source of indoor air pollution in Asia. We assessed the effect of long-term exposure to incense smoke on the body weight and levels of circulating glucose, triglycerides, total cholesterol, HDL-cholesterol, insulin, adiponectin and leptin in Wistar albino rats. Two groups of rats were used. First group (n = 12) was exposed daily to incense smoke for 4 months at the rate of 4 g day(-1) in the exposure chamber. Another group of rats (n = 12), was used as non-exposed control. Blood samples were collected from all animals after 4, 8, 12 and 16 weeks of exposure. Serum glucose, triglycerides, total cholesterol and HDL-cholesterol, LDL-cholesterol insulin, adiponectin and leptin were measured. Our results showed that incense smoke exposure was associated with decreased weight gain and the adverse metabolic changes of increased triglycerides and decreased HDL-cholesterol concentrations. Exposure to incense was also associated with a transient increase of leptin levels. Taken together, these data suggest that incense smoke influences metabolism adversely in rats. The effect of incense smoke on human health and the underlying mechanisms need to be studied further.

  20. The effects of acute gasoline vapour inhalation on some haematological indices of albino Wistar rats

    Institute of Scientific and Technical Information of China (English)

    Chukwudi Onyeka John Okonkwo; Ailende Daniel Ehileboh; Eddy Nwobodo; Charles Chijioke Dike

    2016-01-01

    Objective: To find out if Gasoline vapour has some effects on haematological indices when inhaled by experimental rats. Methods: The standard method for laboratory operating procedure recommended by World Health Organization was used in all the analysis done. Forty two albino Wistar rats comprising twenty one males (160–220 g) and twenty one females (140–190 g) were sampled into six groups consisting of four test groups and two control groups. The test groups were exposed to gasoline vapour for twenty one days. Test group one were exposed to gasoline for 30 min while test group two were exposed to gasoline vapour for 1 h daily. At the end of twenty one days of exposure, blood samples were collected from the rats and their haematological parameters were estimated. Statistical analysis was done using windows SPSS version 16. Results: The results showed a significant decrease (P Conclusions: The results obtained suggest that inhalation exposure to gasoline may result in pancytopaenia and a significant fluctuation in the red blood cell-dependent haematological indices.

  1. Diuretic activity of leaves of Plectranthus amboinicus (Lour Spreng in male albino rats

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    Roshan Patel

    2010-01-01

    Full Text Available The shade-dried powder of leaves of Plectranthus amboinicus (Lour Spreng was subjected to successive extraction using the various solvents (petroleum ether, chloroform, ethanol and water in increasing order of polarity. The preliminary phytochemical analyses were carried out for all the extracts. The analyses of the leaves revealed the presence of alkaloids, carbohydrates, glycosides, proteins, amino acids, flavonoids, quinine, tannins, phenolic compounds and terpenoids. Since the phytoconstituents present in the ethanolic and aqueous extracts were similar, both the extracts were selected for further study. The diuretic properties of ethanolic and aqueous extracts were evaluated by determination of urine volume and electrolyte concentration in male albino rats. Furosemide (10 mg/kg was used as standard while normal saline (0.9% was used as control. Both ethanolic and aqueous extracts (500 mg/kg have shown significant increase in the volume of urine and urinary concentration of Na, K and Cl ions. Thus, from the is study it may be concluded that the leaves of P. amboinicus (Lour Spreng possess diuretic activities.

  2. Diuretic activity of leaves of Plectranthus amboinicus (Lour) Spreng in male albino rats.

    Science.gov (United States)

    Patel, Roshan; Mahobia, Naveen K; Gendle, Ravindra; Kaushik, Basant; Singh, Sudarshan K

    2010-03-01

    The shade-dried powder of leaves of Plectranthus amboinicus (Lour) Spreng was subjected to successive extraction using the various solvents (petroleum ether, chloroform, ethanol and water) in increasing order of polarity. The preliminary phytochemical analyses were carried out for all the extracts. The analyses of the leaves revealed the presence of alkaloids, carbohydrates, glycosides, proteins, amino acids, flavonoids, quinine, tannins, phenolic compounds and terpenoids. Since the phytoconstituents present in the ethanolic and aqueous extracts were similar, both the extracts were selected for further study. The diuretic properties of ethanolic and aqueous extracts were evaluated by determination of urine volume and electrolyte concentration in male albino rats. Furosemide (10 mg/kg) was used as standard while normal saline (0.9%) was used as control. Both ethanolic and aqueous extracts (500 mg/kg) have shown significant increase in the volume of urine and urinary concentration of Na, K and Cl ions. Thus, from the is study it may be concluded that the leaves of P. amboinicus (Lour) Spreng possess diuretic activities. PMID:21808546

  3. Effect of methanol extract ofSynsepalum dulciifcum pulp on some biochemical parameters in albino rats

    Institute of Scientific and Technical Information of China (English)

    Nkwocha Chinelo; Njoku Obioma Uzoma

    2015-01-01

    Objective:To determine the beneficial effects of the methanol extract ofSynsepalum dulcificum on some biochemical parameters. Methods: In this study, rats were orally administered (gavage) with methanol extracts at doses of 0 mg/kg (Group 1, as normal group), 100 mg/kg (Group 2), 200 mg/kg (Group 3) and 500 mg/kg (Group 4) body weight per day for 28 d. Results: Acute toxicity study showed that the methanol extract was not toxic to rats up to 5 000 mg/kg. From the results, the 100 mg/kg doses of the extract significantly (P<0.05) reduced serum levels of bilirubin, low density lipoprotein, alanine aminotransferase and glucose after 14 d compared with those after 28 d. A significant difference (P<0.05) was observed in the malondialdehyde and serum protein concentration in Group 4 while glucose concentration decreased significantly (P<0.05) in Group 1 and Group 4 after 14 d compared with 28 d. The high density lipoprotein significantly increased (P<0.05) in Group 3. Conclusions: The fruit has no negative effect on some biochemical parameters in albino rats.

  4. Pharmacokinetic and pharmacodynamic drug interactions of carbamazepine and glibenclamide in healthy albino Wistar rats

    Directory of Open Access Journals (Sweden)

    S Prashanth

    2011-01-01

    Full Text Available Aims: To find out the pharmacokinetic and pharmacodynamic drug interaction of carbamazepine, a protype drug used to treat painful diabetic neuropathy with glibenclamide in healthy albino Wistar rats following single and multiple dosage treatment. Materials and Methods: Therapeutic doses (TD of glibenclamide and TD of carbamazepine were administered to the animals. The blood glucose levels were estimated by GOD/POD method and the plasma glibenclamide concentrations were estimated by a sensitive RP HPLC method to calculate pharmacokinetic parameters. Results: In single dose study the percentage reduction of blood glucose levels and glibenclamide concentrations of rats treated with both carbamazepine and glibenclamide were significantly increased when compared with glibenclamide alone treated rats and the mechanism behind this interaction may be due to inhibition of P-glycoprotein mediated transport of glibenclamide by carbamazepine, but in multiple dose study the percentage reduction of blood glucose levels and glibenclamide concentrations were reduced and it may be due to inhibition of P-glycoprotein mediated transport and induction of CYP2C9, the enzyme through which glibenclamide is metabolised. Conclusions: In the present study there is a pharmacokinetic and pharmacodynamic interaction between carbamazepine and glibenclamide was observed. The possible interaction involves both P-gp and CYP enzymes. To investigate this type of interactions pre-clinically are helpful to avoid drug-drug interactions in clinical situation.

  5. Effect of Commiphora myrrha extract on some physiological parameters and histological changes in diabetic albino rats

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    Eman G.E. Helal*, Ashraf Mahmoud ** Essam E. El-Badawy

    2005-09-01

    Full Text Available The present study aimed to clarify the antidiabetic activity of Commiphora myrrha (CM aqueous extract on thirty adult male albino rats, which were divided into two groups; the first served as a control group, the second was injected with alloxan (120mg/Kg body weight and divided into two subgroups the first served as diabetic group, the second treated with (CM water extract (0.05mg/100 gm bwt. After 30 days of the treatment half of each group was sacrificed and the other half was left for other 15 days without any additional treatment (recovery period. Our results revealed highly significant decrease (p< 0.01 in blood glucose level and highly significant increase in body weight of the diabetic rats with different histological changes in cells of islets of Langerhans. These histological and physiological changes were ameliorated in rats treated with CM. Water extract of CM has a definite hypoglycemic, hyperinsulinimic effect, on the other hand, a significant increase in body weight, cell number and liver glycogen contents were achieved. The results of the present study clarify the role of CM as an active antidiabetic plant and suggest a relationship between drenching CM extract and insulin production. Other of investigations want be done to detect effects of different doses and time intervals of CM in diabetic animals.

  6. Experimental transmission of Trypanosoma cruzi through the genitalia of albino mice

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    Herrera Leidi

    2001-01-01

    Full Text Available Trypanosoma cruzi is usually transmitted by contact with the excreta of infected Triatominae; among non-vectorial infections, direct transmission through coitus has been proposed. We investigated this possibility by instilling, through the external meatus of the vagina and the penis of previously anesthetized NMRI albino mice, blood of mice infected with strains isolated from Didelphis marsupialis (opossum, strain CO57, Rattus rattus (rat, strain CO22 and human (strain EP. Some animals were allowed to copulate the same day of the instillation. In other experiments, the strains were inoculated in the scrotum. To determine the effect of immunosuppression, some mice were treated with cyclophosphamide 30 days post-instillation. Controls were instilled orally and ocularly. Vaginal instillation with strain CO22 produced systemic infection with tropism to the heart, skeletal muscle, skin, duodenum, pancreas, ovary and sternum. Scrotal inoculation with strain EP likewise invaded liver, spleen, lung, lymph nodes and urogenital organs; while strain CO57 invaded skeletal and cardiac muscle, pancreas, testis, and vas deferens. Penile infection with strain CO22 was detected by xenodiagnosis. Immunosuppression did not increase parasitemia of vaginally infected mice or controls. Mating did not produce infection. Our results show that contact of blood trypomastigotes of T. cruzi with genital mucosa can produce blood and tissue infections. These results are discussed in relation to reports of frequent experimental tropism of T. cruzi toward urogenital organs.

  7. Experimental transmission of Trypanosoma cruzi through the genitalia of albino mice.

    Science.gov (United States)

    Herrera, L; Urdaneta-Morales, S

    2001-07-01

    Trypanosoma cruzi is usually transmitted by contact with the excreta of infected Triatominae; among non-vectorial infections, direct transmission through coitus has been proposed. We investigated this possibility by instilling, through the external meatus of the vagina and the penis of previously anesthetized NMRI albino mice, blood of mice infected with strains isolated from Didelphis marsupialis (opossum, strain CO57), Rattus rattus (rat, strain CO22) and human (strain EP). Some animals were allowed to copulate the same day of the instillation. In other experiments, the strains were inoculated in the scrotum. To determine the effect of immunosuppression, some mice were treated with cyclophosphamide 30 days post-instillation. Controls were instilled orally and ocularly. Vaginal instillation with strain CO22 produced systemic infection with tropism to the heart, skeletal muscle, skin, duodenum, pancreas, ovary and sternum. Scrotal inoculation with strain EP likewise invaded liver, spleen, lung, lymph nodes and urogenital organs; while strain CO57 invaded skeletal and cardiac muscle, pancreas, testis, and vas deferens. Penile infection with strain CO22 was detected by xenodiagnosis. Immunosuppression did not increase parasitemia of vaginally infected mice or controls. Mating did not produce infection. Our results show that contact of blood trypomastigotes of T. cruzi with genital mucosa can produce blood and tissue infections. These results are discussed in relation to reports of frequent experimental tropism of T. cruzi toward urogenital organs. PMID:11500777

  8. Hypoglycaemic and Antioxidant Activity of SPHAG - a Poly Herbal Formulation in Alloxan Induced Wistar Albino Rats

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    Thamizh Selvam N

    2015-04-01

    Full Text Available Management of Diabetes mellitus is one of the greatest challenges among the developing and developed countries. The use of herbal medicine is steadily growing in the management of various diseases all over the world. The present study has been taken up on a poly herbal formulation -SPHAG, a combination of aqueous extracts of plants Solanum nigrum, Premna corymbosa, Holarrhena pubescens, Alstonia scholaris and Gymnema sylvestre for its hypoglycaemic and antioxidant activity in alloxan induced diabetic Wistar albino rats. The four groups containing 6 animals in each group, like Healthy Control, Disease Control, SPHAG lower dose(250 mg/kg.b.wt. and SPHAG higher dose (500 mg/kg.b.wt. were maintained. The oral administration of SPHAG had showed significant reduction in the glucose level and HbA1C level when compared with Disease Control. Biochemical parameters comprising of liver function and renal function tests had shown improved health status in SPHAG treated groups over Disease Control group. The antioxidant enzymes superoxide dismutase, Glutathione peroxidase levels in blood and tissues including liver, kidney and heart were found to be decreased in the Disease control group. SPHAG treated animals showed significant improvement on the antioxidant enzyme levels and the efficacy is found to be dose dependent. Thus, the present study has demonstrated hypoglycaemic and antioxidant potential of SPHAG in the experimental animals. The synergistic contribution of major phyto-constituents of SPHAG i.e. flavonoids and phenols are expected for its biopotency and efficacy.

  9. Radiomodification by Aloe vera leaf extract on skin of Swiss albino mice exposed to gamma radiation

    International Nuclear Information System (INIS)

    The development of effective radioprotectors and radiorecovery drugs is of great importance in view of their potential application during both planned (e.g. radiotherapy) and unplanned (e.g. in nuclear industry, natural background radiation emanating from the earth or other sources) radiation exposure. Over the past 50 years, research in the development of radioprotectors has focused on screening a plethora of chemical and biological compounds. Several synthetic chemical compounds have been tested for protection against radiation. But they have limited use due to inherent toxicity. Herbal medicine is still the mainstay of about 75-80 percent of the world population mainly in the developing nations for primary health care because of better cultural acceptability, better compatibility with the human body and lesser side effects. Thus, natural products offer an alternative to their synthetic counterparts due to low toxicity with no side effects. The present investigation has been an attempt to asses the radioprotective efficacy of Aloe vera leaf extract on biochemical alterations in skin of Swiss albino mice

  10. Evaluation of antidiabetic, antioxidant effect and safety profile of gomutra ark in Wistar albino rats.

    Science.gov (United States)

    Sachdev, Devender O; Gosavi, Devesh D; Salwe, Kartik J

    2012-01-01

    The effect of Gomutra ark (GoA) on experimental alloxan-induced diabetes in rats was studied. For this purpose, Wistar albino rats of either sex weighing 200-250 g were used. The biochemical parameters like blood sugar, vitamin C, and malondialdehyde release were measured. The safety profile of GoA was evaluated using acute and chronic toxicity studies. GoA significantly lowers blood glucose in diabetic rats although the observed effect was found to be less than glibenclamide. It significantly lowers the level of malondialdehyde and vitamin C in diabetic rats. No toxicity was observed even when cow urine was given 32 times of the study dose in acute toxicity and no significant changes were seen when it was used chronically, which suggests that cow urine is having a very high therapeutic index. This study supports the traditional use of GoA in diabetes and is having a high therapeutic index and is safe for chronic use. However, further studies are needed to elucidate the mechanism of action of Gomutra ark.

  11. Evaluation of analgesic activity of lotus seeds (Nelumbo nucifera in albino rats

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    P. Vikrama Chakravarthi

    Full Text Available The present study was undertaken to assess the analgesic effect of red and white lotus (Nelumbo nucifera seeds in albino rats. The analgesic action in acute pain model was studied by tail flick method. The methanolic extracts of lotus seeds were screened for phytochemical analysis and it’s revealed the presence of all components excluding tannins. The Forty eight adult Sprague-Dawley rats were divided into six groups of eight each and maintained under ideal laboratory conditions. Group I was taken as control and group II treated with the standard drug diclofenac potassium @ 3mg/kg on 7thday of study. The methanolic extract of Nelumbo nucifera seeds of red and white varieties @ 400mg/kg and 600mg/kg were fed to group III, IV, V and VI respectively, for 7 days.  It is observed that the both lotus seed extracts shows considerable analgesic effect in acute pain model which is less than the effect of Diclofenac group. The higher dose groups of lotus seed extracts (600mg/kg were revealed more activity than their corresponding lower dose. While evaluating all groups, the higher dose group of white lotus seed (600mg/kg, exhibited more pronounced activity than other extracts. [Vet World 2009; 2(9.000: 355-357

  12. Anti-inflammatory activity of red and white lotus seeds (Nelumbo nucifera in albino rats

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    P. Vikrama Chakravarthi

    2010-08-01

    Full Text Available The present study was carried out to evaluate the anti-inflammatory activity of red and white lotus seeds in albino rats. The Carrageenin induced paw edema model was used for studying the anti-inflammatory activity. The cyclooxygenase-2 (COX-2 enzyme inhibition assay was carried out in spectrophotometer to identify the specific mode of action. Forty eight adult Sprague-Dawley rats were used in this experiment. They were divided into six groups of eight each and maintained under ideal laboratory conditions. Group I was taken as control and group II treated with the standard drug diclofenac potassium @ 3mg/kg/celecoxib @ 10mg/kg (in case of COX–2 assay on 7th day of study. The methanolic extract of Nelumbo nucifera seeds of red and white varieties @ 400mg/kg and 600mg/kg were fed to group III, IV, V and VI respectively, for 7 days. All groups of lotus seed extracts were revealed anti-inflammatory activity in Carragenin induced inflammation as well as in COX-2 enzyme inhibition assay. While comparing all groups, the higher dose group of white lotus seed extracts, exhibited more pronounced inhibition than other groups. [Vet World 2010; 3(4.000: 157-159

  13. ANTIANXIETY EFFECT OF ETHANOLIC EXTRACT OF LEAVES OF TYLOPHORA INDICA IN WISTAR ALBINO RATS

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    Shyamjith Manikkoth

    2013-02-01

    Full Text Available Pathological anxiety is one of the most common mental disorders in humans. Anxiolytic drugs, mostly belonging to the benzodiazepine (BDZ group and serotonergic groups are widely used to treat anxiety. However the clinical uses of these established drugs are associated with lot of adverse effects. Therefore the development of new agent possessing anxiolytic effect with minimal or no adverse effects would be of great importance in the treatment of anxiety related disorders. Very high importance is given to the phytoconstituents by the scientific community for a new anxiolytic agent which is devoid of side effects/ minimal adverse effects. In this research work the ethanolic extract of Tylophora indica (300 mg/kg body weight was administered oral for ten days to Wistar albino rats for screening its anxiolytic effect by using Elevated Plus Maze (EPM and Light Dark Arena (LDA test. The results of our study demonstrated that the ethanolic extract of Tylophora indica has significant anxiolytic activity in EPM and LDA models of anxiety.

  14. Impact of dietary oils and fats on lipid peroxidation in liver and blood of albino rats

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    Rafaat Mohamed Elsanhoty; Mohamed Fawzy Ramadan

    2014-01-01

    Objective:To investigate the effects of different dietary fat and oils (differing in their degree of saturation and unsaturation) on lipid peroxidation in liver and blood of rats. Methods:The study was conducted on 50 albino rats that were randomly divided into 5 groups of 10 animals. The groups were fed on dietary butter (Group I), margarine (Group II), olive oil (Group III), sunflower oil (Group IV) and corn oil (Group V) for 7 weeks. After 12 h of diet removal, livers were excised and blood was collected to measure malondialdehyde (MDA) levels in the supernatant of liver homogenate and in blood. Blood superoxide dismutase activity (SOD), glutathione peroxidase activity (GPx), serum vitamin E and total antioxidant capacity (TAC) levels were also measured to determine the effects of fats and oils on lipid peroxidation. Results: The results indicated that no significant differences were observed in SOD activity, vitamin E and TAC levels between the five groups. However, there was significant decrease of GPx activity in groups IV and V when compared with other groups. The results indicated that feeding corn oil caused significant increases in liver and blood MDA levels as compared with other oils and fats. There were positive correlations between SOD and GPx, vitamin E and TAC as well as between GPx and TAC (r:0.743;P Conclusions:The results demonstrated that feeding oils rich in polyunsaturated fatty acids (PUFA) increases lipid peroxidation significantly and may raise the susceptibility of tissues to free radical oxidative damage.

  15. Acute toxicity study of Vilocym Premix (herbal growth promoter for Livestockin Wistar Albino Rat

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    A.H. Ahmad

    2009-06-01

    Full Text Available An experimental study with the objective of safety evaluation of Vilocym Premix, herbal growth promoter for Livestock (supplied by Ayurvet Ltd., Baddi, India, was done as per standard guidelines of OECD-423 for acute toxicity testing. Vilocym Premix is a scientifically developed combination of herbs that contains herbal ingredients namely Azadirachta indica, Curcuma longa & many more alongwith natural zeolites. The study was done in 3 males and 3 female Wistar Albino rats, which were administered an initial dose of 50 mg/kg body weight followed by dose rates of 300, 500 & 5000 mg/kg body weight of test compound. The animals were observed for signs of convulsions, tremors, circling, depression, excitement and mortality. Body weight was recorded at 0,7th and 14th day and plasma total protein, albumin; AST and ALT were measured after 3rd day of experiment. No abnormal sign of symptoms were observed in any of the animal fed with Vilocym Premix at the dose rate of 50, 300, 500 & 5000 mg/kg. No mortality was observed indicating safety of herbal premix. [Vet. World 2009; 2(3.000: 100-102

  16. Toxicity assessment of ethanol extract of Solanum villosum (Mill on wistar albino rats.

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    Venkatesh R

    2014-07-01

    Full Text Available Purpose: To evaluate the potential toxicity of ethanol extract of the medicinal plant Solanum villosum (Mill. Methods: Ethanol extract of S. villosum administered orally at ranges of doses 100, 200, 400, 600 and 800 mg/kg/bw to assess its impact on biochemical indices of Wistar albino rats. Hematological profile, biochemical assays, antioxidant and lipid peroxidation assays were compared between control and experimental animals. An acute toxicity test was performed in rats at different concentration of ethanol extract of S. villosum in order to establish the approximate oral lethal dose (LD 50. Results: No mortality occurred during the two weeks experimental period, in both control and experimental groups. The changes in biochemical parameters were statistically insignificant at p<0.05 levels. The treated rats showed that very less toxic symptoms only after 800 mg/kg/bw. These observations were supported by hematological and liver function markers. Conclusions: The medicinal plant Solanum villosum can be administered orally at a dose range of 200 mg/kg/bw was very effective and without any side effects. Ethanol extract of S. villosum is not toxic and therefore it may be used safely in clinical trials. It is the first documented report about the plant Solanum villosum (Mill in the toxicity assessment study.

  17. GASTROPROTECTIVE ACTIVITY OF PONGAMIA PINNATA STEM BARK IN WISTAR ALBINO RATS

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    Khumanthem Deepak Singh

    2011-02-01

    Full Text Available The present study was carried out with the stem bark of Pongamia pinnata Linn, belonging to the family Fabaceae. It is one of the fast growing, glabrous, deciduous tree and has recently gained importance as a commercial source of alkaloids like kaempferol, karanjin. Methanolic extract of Pongamia pinnata was subjected to phytochemical screening. Acute gastric ulceration was produced by oral administration of various noxious chemicals including Ethanol, Indomethacin, Pylorus ligation and Cold restraint stress. In pharmacological screening, the effect of methanolic extract of stem bark of Pongamia pinnata Linn was evaluated in Wistar Albino Rats of either sex(150-200g for Antiulcer activity at a dose of 200mg/kg and 400mg/kg(p.o and the effect was compared with Omeprazole(10mg/kg p.o as standard drug. The extract decreased the ulcer index thereby increasing the percentage ulcer protection. Thus from the study and literature, it can be concluded that Pongamia pinnata Linn have potent antiulcer activity.

  18. ANTIOXIDANT ACTIVITY OF GARCINIA GUMMI GUTTA (LINN IN PARACETAMOL INTOXICATED WISTAR ALBINO RATS

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    Thamizh Selvam N

    2011-11-01

    Full Text Available The study was carried out to determine antioxidant activity of methanolic extract of Garcinia gummi gutta fruit in the selective in vivo model system using Wistar albino rats. The experiment was comprised of five groups such as Healthy control, Disease control (Paracetamol treated, Positive control (Silymarin treated, test groups G. gutta lower dose(250mg/kg b.wt and higher dose (500 mg/kg b.wt. The study period was 10 days and the biochemical profile including SGOT, ALKP, Total protein and antioxidant enzymes Superoxide dismutase, Glutathione peroxidase and Glutathione reductase levels were evaluated in blood and tissue samples (liver, kidney, heart of all the experimental animals. The study proved that there was a significant improvement of antioxidant enzyme levels in the G. gutta treated groups as compared to the control groups and the efficacy was found to be dose dependent. The study proved the antioxidant activity of G. gutta extract and further study on characterization of phytoconstituents is under progress for harnessing G. gutta as a drug formulation.

  19. Embryotoxic and Teratogenic Effects of Nickel in Swiss Albino Mice during Organogenetic Period

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    Shivi Saini

    2013-01-01

    Full Text Available The present study evaluates potential hazardous of nickel (Ni+2 as NiCl2·6H2O to Swiss albino mice fetus. Ni was administered orally on body weight base from days 6 to 13 of gestation period. Based on LD50, Ni doses (46.125, 92.25, and 184.5 mg Ni/kg b.wt. were used. On day 18 of gestation, uteri of the sacrificed dams were examined. A dose-dependent decrease ( in the body weight of the pregnant females and fetuses during the gestation period was observed. Number of implant sites and placental weight at all the three dose levels was lower compared with their respective control groups. Average number of live fetuses/dams reduced significantly ( at 184.5 mg Ni/kg b.wt. with concomitant increase in the percentage of postimplantation death and percentage of resorbed, macerated, and dead fetuses, respectively. Exposure increased the fetal malformations, namely, hydrocephaly, open eyelids, microphthalmia, exophthalmia, club foot, umbilical hernia, and skeletal anomalies. Reduced ossification of nasal, frontal, parietal, intraparietal, and supraoccipital bones, absence/gap between the ribs, reduced/fused sternebrae, vertebral centra, and caudal vertebrae, reduced pelvic elements, absence of carpals, metacarpals, tarsals, metatarsals, and phalanges were distinct. This indicates vulnerability of the mice fetus to nickel during prenatal exposure.

  20. Protective effects of lupeol and mango extract against androgen induced oxidative stress in Swiss albino mice

    Institute of Scientific and Technical Information of China (English)

    Sahdeo Prasad; Neetu Kalra; Madhulika Singh; Yogeshwer Shukla

    2008-01-01

    Aim: To investigate antioxidant potential of lupeol/mango pulp extract (MPE) in testosterone induced oxidative stress in prostate of male Swiss albino mice. Methods: Oral treatment of lupeol (1 mg/animal) and MPE (1 mL [20% w/v]/animal) was given separately to animals along with subcutaneous injection of testosterone (5 mg/kg body weight)consecutively for 15 days. At the end of the study period, the prostate was dissected out for the determination of reactive oxygen species (ROS) levels, lipid peroxidation and antioxidant enzymes status (catalase, superoxide dismutase,glutathione reductase, glutathione-S-transferase). Results: In testosterone treated animals, increased ROS resulted in depletion of antioxidant enzymes and increase in lipid peroxidation in mouse prostate. However, lupeol/MPE treatment resulted in a decrease in ROS levels with restoration in the levels of lipid peroxidation and antioxidant enzymes. Conclusion: The results of the present study demonstrate that lupeol/MPE are effective in combating oxidative stress-induced cellular injury of mouse prostate. Mango and its constituents, therefore, deserve study as a potential chemopreventive agent against prostate cancer.

  1. ANTI IMPLANTATION AND PREGNANCY INTERRUPTION ACTIVITY OF JAPAKUSUMA (HIBISCUS ROSA SINENSIS IN ALBINO RATS

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    Kashinath Hadimur

    2013-06-01

    Full Text Available Increase in population has affected many socio-economic conditions of people by increasing crimes, illiteracy, destructive activities, diseases, improper food and shelter. Thus to control this population and limit the family size at a personal level and at a national level, modern contraceptive methods and medicines were introduced long back. There are many new contraceptives available now, but they have various side effects. Some traditional practitioners used to dispense oral contraceptives mentioned in Ayurvedic classics. Such as 1 Pippali (Piper longum, Vidanga (Emblica ribes and Tankana (Sodii Biboras. 2 Talisapatra (Taxus baccata and Gairika (Hematite with cold water and 3 Kanji bhavita Japakusuma (Hibiscus rosa sinensis. An experimental study on above mentioned 1 and 2 formulations has proved its efficacy as temporary contraceptive medicine. To evaluate the permanent or long term temporary contraceptive effect of Japakusuma, an attempt was made in this study. Study was conducted by Choudary and Khanna method on 18 female, 36 male (for mating albino rats. Japakusuma, Propylene glycol, Ovral L formed the materials. Single dose was administered on proestrous stage of rat oestrous cycle and observed for anti-implantation and pregnancy interruption activity. Test drug showed significant anti implantation and pregnancy interruption activity. Thus showing the temporary contraceptive activity of Japakusuma (Hibiscus rosa sinensis.

  2. Asociación de sobrepeso y uso de glucocorticoides con componentes del síndrome metabólico en pacientes oncológicos en quimioterapia

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    Karla Sánchez-Lara

    2013-02-01

    Full Text Available En pacientes con diagnostico de cáncer en tratamiento con quimioterapia es común encontrar componentes del síndrome metabólico (SM como sobrepeso, obesidad, resistencia a la insulina e hiperglicemia. Estos componentes se han asociado a mayor recurrencia de la enfermedad. Objetivos: describir la relación entre el IMC, el uso de glucocorticoides y el sitio de tumor con los factores del SM en pacientes tratados con quimioterapia de un centro hospitalario universitario. Métodos: Estudio retrospectivo donde se revisaron expedientes de pacientes tratados en el centro oncológico del 2008 al 2010, con diagnóstico de cáncer y en tratamiento con quimioterapia sistémica. Se recopilo información acerca de datos antropométricos y criterios de SM definidos por ATP III. Resultados: Se incluyeron 158 pacientes, 75,9% genero femenino, los tumores mas comunes fueron mama, gastrointestinal y pulmón. Más de la mitad de los pacientes presentaron >3 componentes del SM (56,3%; El 43,6% de pacientes recibieron dexametasona como parte del tratamiento. El IMC promedio fue de 25,3 Kg/m². El diagnostico de cáncer de mama en tratamiento con quimioterapia se asoció con la presencia de 3 o más componentes del SM. La administración de glucocorticoides no se asoció a la presencia de SM. Conclusiones: los sujetos con IMC>25 tienen 12,6 veces más el riesgo de padecer SM, independientemente del uso de glucocorticoides en el tratamiento. El mantenimiento de un peso adecuado en el paciente oncológico es importante para reducir los factores de riesgo del SM.

  3. RELACIÓN DE LA CALIDAD DE VIDA CON DIFERENTES MODELOS DE ATENCIÓN DOMICILIARIA EN ENFERMOS ONCOLÓGICOS TERMINALES DE UN ÁREA SANITARIA DE MADRID

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    Yolanda Agra Varela

    2003-01-01

    Full Text Available Fundamentos: En este trabajo se evalúa la efectividad de los cuidados paliativos a domicilio con el objetivo de determinar si los enfermos con cáncer terminal tratados por Equipos de Soporte de Atención Domiciliaria presentan mejor calidad de vida que los tratados por Equipos de Atención Primaria. Métodos: Estudio prospectivo cuasi experimental realizado en el Área 4 del Imsalud de Madrid con enfermos referidos desde el hospital a Equipos de Soporte de Atención Domiciliaria o a Equipos de Atención Primaria. La variable estudiada fue la calidad de vida medida a través del Rotterdam Symptom Check List y el Hospital Anxiety and Depression Scale. Para el análisis estadístico se utilizó MANOVA, ANOVA de medidas repetidas y el test de Friedman. Resultados: 165 enfermos fueron tratados por Equipos de Soporte de Atención Domiciliaria y 56 por Equipos de Atención Primaria. Los primeros presentaron mejor puntuación en las escalas global (diferencia de medias: 9,5; IC 95%: 2,3-16,67 y dolor (diferencia de medias: 6,4; IC 9%: 1,14-11,43 del Rotterdam Symptom Check List en la primera semana del estudio. El tamaño del efecto fue mayor en el grupo Equipos de Soporte de Atención Domiciliaria. La prescripción de fármacos y el lugar de la muerte fue diferente en ambos grupos. Conclusiones:Al principio del estudio los enfermos tratados por Equipos de Soporte de Atención Domiciliaria presentaron una mejor percepción del estado de salud que los tratados por Equipos de Atención Primaria. No obstante, el importante número de pérdidas a lo largo del mismo hace que haya que mirar estos resultados con precaución.

  4. Relación de la calidad de vida con diferentes modelos de atención domiciliaria en enfermos oncológicos terminales de un área sanitaria de Madrid

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    Agra Varela Yolanda

    2003-01-01

    Full Text Available Fundamentos: En este trabajo se evalúa la efectividad de los cuidados paliativos a domicilio con el objetivo de determinar si los enfermos con cáncer terminal tratados por Equipos de Soporte de Atención Domiciliaria presentan mejor calidad de vida que los tratados por Equipos de Atención Primaria. Métodos: Estudio prospectivo cuasi experimental realizado en el Área 4 del Imsalud de Madrid con enfermos referidos desde el hospital a Equipos de Soporte de Atención Domiciliaria o a Equipos de Atención Primaria. La variable estudiada fue la calidad de vida medida a través del Rotterdam Symptom Check List y el Hospital Anxiety and Depression Scale. Para el análisis estadístico se utilizó MANOVA, ANOVA de medidas repetidas y el test de Friedman. Resultados: 165 enfermos fueron tratados por Equipos de Soporte de Atención Domiciliaria y 56 por Equipos de Atención Primaria. Los primeros presentaron mejor puntuación en las escalas global (diferencia de medias: 9,5; IC 95%: 2,3-16,67 y dolor (diferencia de medias: 6,4; IC 9%: 1,14-11,43 del Rotterdam Symptom Check List en la primera semana del estudio. El tamaño del efecto fue mayor en el grupo Equipos de Soporte de Atención Domiciliaria. La prescripción de fármacos y el lugar de la muerte fue diferente en ambos grupos. Conclusiones: Al principio del estudio los enfermos tratados por Equipos de Soporte de Atención Domiciliaria presentaron una mejor percepción del estado de salud que los tratados por Equipos de Atención Primaria. No obstante, el importante número de pérdidas a lo largo del mismo hace que haya que mirar estos resultados con precaución.

  5. La carga precoz de los implantes GMI con conexión interna y superficie arenada y grabada

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    E. Velasco Ortega

    2014-08-01

    Full Text Available Introducción: La implantología oral representa en la actualidad, una modalidad terapéutica odontológica en los pacientes con pérdida dental total y parcial. El estudio muestra la evaluación de los pacientes tratados mediante carga precoz de implantes de titanio con conexión interna y superficie arenada y grabada. Métodos: 39 pacientes con pérdidas dentales fueron tratados con implantes con conexión interna y superficie arenada y grabada Frontier GMI®. Los implantes fueron cargados funcionalmente tras un periodo de tiempo de 6 semanas en la mandíbula y 8 semanas en el maxilar superior. Los hallazgos clínicos (implantológicos y prostodóncicos se han seguido durante 1 año. Resultados: 111 implantes fueron insertados en ambos maxilares (50 en el maxilar superior y 61 en la mandíbula para su rehabilitación prostodóncica. 44 implantes fueron insertados en el sector anterior y 67 implantes en el sector posterior. Después de 1 año de seguimiento clínico, los resultados indican una supervivencia y éxito de los implantes del 99,1%. Durante el periodo de cicatrización libre de carga funcional, se perdió 1 implante por movilidad. Como complicaciones tardías hubo un caso de periimplantitis. Las restauraciones prostodóncicas incluyeron 30 coronas unitarias, 15 puentes fijos, 5 sobredentaduras con bolas y 2 rehabilitaciones totales fijas. Conclusiones: Los hallazgos clínicos del presente estudio indican que la rehabilitación prostodóncica mediante la inserción de implantes de titanio con conexión interna y superficie arenada + grabada, y cargados precozmente, representa una terapéutica odontológica con éxito elevado.

  6. preescolares desnutridos con madres con obesidad y sin obesidad

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    Viridiana Vanessa Conzuelo-González

    2009-01-01

    Full Text Available El primer objetivo fue conocer cuántos menores de cinco años con diferentes grados de desnutrición tienen una madre con sobrepeso/obesidad/ en una comunidad indígena que vive en extrema pobreza y bajo condiciones de migración masculina internacional. El segundo fue comparar tres variables socionutricionales (ingreso familiar, educación de la madre y adecuación nutrimental de la dieta diaria entre estos hogares y los hogares con desnutrición infantil y madres sin obesidad. Se realizó un estudio transversal (2006-2007, en la comunidad mazahua de San Francisco Tepeolulco, Municipio de Temascalcingo; que incluyó a 85 hogares integrados por preescolares con desnutrición inscritos al programa Oportunidades. Se determinó el estado nutrición de los preescolares con indicadores antropométricos y se obtuvo el IMC de las madres de estos infantes. Se aplicó una encuesta socionutricional, incluida el recordatorio de 24 horas, y complementado con la observación participante (cualitativa. Se encontró que 83% de las madres mazahuas presentaron sobrepeso u obesidad. El estado de nutrición de los preescolares con madres con obesidad presentó un porcentaje mayor de desnutrición (76%. En la variable género, se encontró que 54% de los niños con madres con obesidad tenía baja talla. Al relacionar el nivel educativo de la madre, esta variable resultó ser estadísticamente significativa (p=0.015, donde el analfabetismo está más relacionado con la desnutrición infantil que tienen madres de bajo y/o peso normal. La elevada prevalencia de hogares conformados con preescolares con desnutrición y madres con obesidad, es un síntoma más de la pobreza en zonas indígenas en México, con bajo índice de desarrollo humano.

  7. Crear con el movimiento: la danza como proceso de investigación

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    Anadel Lynton Snyder

    2006-01-01

    Full Text Available Tanto en la educación profesional como en las clases de danza para aficionados y dentro de la educación artística escolarizada, “la danza” se enseña casi siempre como vocabularios codificados de movimientos a dominar a través de la repetición descontextualizados de su origen histórico y cultural y tratados como sistemas cerrados. La investigación y reflexión sobre los usos de la danza y otros lenguajes expresivos y de temáticas significativas en las comunidades de donde provienen los estudiantes son otras herramientas imprescindibles del maestro y sus alumnos. El maestro puede sistematizar el uso de la investigación acción para analizar y adecuar su propia práctica docente a sus metas y compartir sus experiencias con otros. Describiré algunas experiencias recientes de mi práctica docente en talleres de improvisación, creación y movimiento y lo que yo llamo Danzando en Comunidad, un método para crear con el movimiento, aplicable al trabajo con personas de cualquier edad que se interesan en hacer danzas basadas en sus propias ideas.

  8. Função renal em pacientes com leishmaniose muco-cutânea tratados com antimoniais pentavalentes

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    Joel Paulo Russomano Veiga

    1985-12-01

    Full Text Available Avaliou-se a função renal em 10 pacientes com leishmaniose muco-cutânea tratados com glucantime (antimoniato de Meglumine, Rhodia ou Pentostam (estibogluconato de sólio, Wellcome. Durante o uso das drogas, verificou-se a existência de um defeito na capacidade concentrante do rim, obtendo-se menores valores da osmolaridade urinária máxima e de depuração negativa máxima de água livre, neste período, em relação aos testes efetuados antes do tratamento. A capacidade de concentração urinária normalizou-se em 5, de 8 pacientes estudados no período de 15 a 30 dias, após a suspensão dos medicamentos, embora com valores de osmolaridade urinária máxima inferiores aos obtidos antes do tratamento. Em dois pacientes surgiu proteínúria, acima de 150 mg/dia, com o uso dos antimoniais, normalizando-se posteriormente. A depuração de creatinina endógena não se alterou significativamente com o uso das drogas. Os resultados sugerem que os antimoniais pentavalentes podem levar a uma disfunção tubular renal, caracterizada por um defeito na capacidade de concentrar a urina, reversível após a retirada dos medicamentos.

  9. Qualidade de caquis Fuyu tratados com cálcio em pré-colheita e armazenados sob atmosfera modificada

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    FERRI VALDECIR CARLOS

    2002-01-01

    Full Text Available Avaliou-se a eficiência do cálcio (CaCl2 na conservação de caquis Fuyu armazenados em temperatura ambiente (TA, atmosfera refrigerada (AR e modificada (AM. Utilizou-se um delineamento inteiramente casualizado, com quatro repetições. Os caquizeiros foram tratados com 1% de CaCl2, em pulverizações de cobertura total, a cada 15 dias, a partir de 90 dias antes da data prevista para a colheita. Para a testemunha, pulverizaram-se as plantas com água destilada. As frutas foram colhidas com 65-75mm de diâmetro, coloração verde-amarelada e armazenadas em: 1 - TA (23±3ºC e 75±5%; 2 - AR (0±0,5ºC e 90±5% de umidade relativa; e 3 - AM (filme de polietileno de baixa densidade 33µm, 29x46cm, 0±0,5ºC e umidade relativa 90±5%, durante 80 dias. As frutas foram submetidas a avaliações de perda de peso, firmeza de polpa, sólidos solúveis totais e escurecimento da epiderme. As avaliações foram efetuadas 24 e 96 horas após as frutas serem retiradas da câmara. Para as frutas armazenadas em TA, as análises foram realizadas a cada 4 dias, durante 20 dias. A aplicação de CaCl2 em pré-colheita melhorou o potencial de armazenamento, e a AM teve efeito sinérgico ao CaCl2 na melhoria do potencial de conservação dos caquis.

  10. Profiling and comparison of color body wall transcriptome of normal juvenile sea cucumber ( Apostichopus japonicus) and those produced by crossing albino

    Science.gov (United States)

    Ma, Deyou; Yang, Hongsheng; Sun, Lina

    2014-12-01

    Sea cucumber ( Apostichopus japonicus) is one of the most important aquaculture animals in China. Usually its normal body color is black that fits its living environment. The juvenile individuals obtained by crossing albino sea cucumber segregated in body color. To document the transcriptome difference between albino associating sea cucumber and the control, we sequenced their transcriptomes with RNA-seq. Approximately, 4.790 million (M) and 4.884 M reads, 200 nt in length, were generated from the body wall of albino associating sea cucumber and the control, respectively, from them, 9550 (46.81%) putative genes were identified. In total, 583 genes were found to express differentially between albino associating sea cucumber and the control. Of these differentially expressed genes (DEGs), 4.8% changed more than five-folds. The expression levels of eight DEGs were confirmed with real-time PCR. The changing trend of these DEGs detected with real-time PCR agreed well with that detected with RNA-seq, although the change degree of some DEGs was different. Four significantly enriched pathways were identified for DEGs, which included phagocytosis, Staphylococcus aureus infection, ECM-receptor interaction and focal adhesion. These pathways were helpful for understanding the physiological difference between albino associating sea cucumber and the control.

  11. Extracts of Azadirachta indica and Melia azedarach seeds inhibit folliculogenesis in albino rats

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    Roop J.K.

    2005-01-01

    Full Text Available The seed oil of Azadirachta indica A. Juss (neem is used in traditional medicine for its antidiabetic, spermicidal, antifertility, antibacterial, and wound healing properties. The present study was undertaken to investigate the quantitative aspects of follicular development in cyclic female albino rats (135 ± 10 g; 8 groups with 6 animals in each group after oral administration of polar (PF and non-polar (NPF fractions of A. indica seed extract at 3 and 6 mg kg body weight-1 day-1 and Melia azedarach Linn. (dharek seed extract at 24 mg kg body weight-1 day-1 for 18 days. The extracts were prepared using a flash evaporator at 35°C and then dissolved in olive oil to prepare doses on a per kg body weight basis. There was a significant reduction (P = 0.05 in the number of normal single layered follicles (A. indica: 0.67 ± 0.33 and 4.67 ± 2.03 after 3 and 6 mg/kg NPF, and 3.33 ± 1.67 and 1.00 ± 1.00 after 3 and 6 mg/kg PF vs control: 72.67 ± 9.14 and M. azedarach: 0.60 ± 0.40 and 1.80 ± 1.2 after 24 mg/kg PF and NPF, respectively, vs control: 73.40 ± 7.02 and follicles in various stages (I-VII of follicular development in all treatment groups. These extracts also significantly reduced (P = 0.05 the total number of normal follicles in the neem (14.67 ± 5.93 and 1.00 ± 1.00 after 3 and 6 mg/kg PF and 3.67 ± 0.88 and 5.33 ± 2.03 after 3 and 6 mg/kg NPF and dharek (13.00 ± 3.58 and 14.60 ± 2.25 after 24 mg/kg NPF and PF treatments compared to control (216.00 ± 15.72 and 222.20 ± 19.52, respectively. Currently, indiscriminate use of persistent and toxic rodenticides to control rodent populations has created serious problems such as resistance and environmental contamination. Therefore, it becomes necessary to use ecologically safe and biologically active botanical substances that are metabolized and are not passed on to the next trophic level, and that interfere with the reproductive potential particularly growth and differentiation of

  12. Effect Of Some Slimming Drugs On Haematological And Some Vital Signs Of Albino Rats

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    Eman G.E. Helal* and Shadia, A. Radwan**

    2007-03-01

    Full Text Available Some of slimming drugs had been withdrawn from markets so, the present study was conducted to follow the effect of three different anorexic drugs; on the haematological and physical parameters of adults albino rats. The used drugs differ in their nature, where the first one i.e., apple-lite is a fully natural substance, the 2nd one i.e., mirapront-N. is a chemical substance and the 3rd one i.e., tenuate is a synthetic foamy filler substance. Fourty adult male albino rats (130 20g were randomly divided into four groups, ten on each treated group and ten for the first group which conserved as control group. The 2nd group was treated daily with apple-lite (3.5mg/ 100g.b.wt, the 3rd group was treated daily with mirapro-N (0.14mg/100g.b.wt and the 4th group was treated daily with tenuate (0.1 mg/100g.b.wt. Haematological parameters (RBCs, WBCs count, haemoglobin content (Hb, hematocrit value (Hct%, mean cell volume (MCV, mean cell heamoglobin (MCH and mean cell heamoglobin concentration (MCHC were detected after 30 days of treatment and also after 15 days of the last treatment as a recovery period. Also, body weight, percent of organs weight/body weight, skin-fold thickness and some vital measurements i.e. heart beats, respiratory rate and rectal temperature were recorded after the same periods of treatment and recovery. Haematological studies revealed that RBCs count, total WBCs count, Hb and Hct values were significantly decreased in the three groups treated daily with anorexic drugs for 30 days. These changes aere also recorded after the recovery period except in apple-lite treated group which showed insignificant change in RBCs and Hb after the recovery period. The calculated mean cell haemoglobin concentration (MCHC recorded significant increase in apple-lite after treated and recovery periods, while non significant changes in MCHC were observed after mirapro-N and tenuate groups after treatment 30 daysfor 30 days but significant increase of

  13. Entrevista con Alberto Tenenti.

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    - Consejo de Redacción

    1995-01-01

    Full Text Available Gran especialista en historia moderna, Alberto Tenenti nació en Viareggio, en 1924. Tras realizar estudios superiores en Italia, trabajó en el Centre National de la Recherche Scientifique varios años, asesorado por Lucien Febvre. Ha dirigido el Archivo del Estado de Brescia; y, más tarde, ha enseñado en París, desde una cátedra en la École Pratique des Hautes Études en Sciences Sociales (VI Sección, alIado de Braudel. Su Il senso della morte e l'amore della vita nel Rinascimento, de 1957, es una obra maestra sobre los orígenes de la sensibilidad moderna: sin olvidar el naciente vitalismo, estudia el desarrollo de dos motivos, el del ars moriendi, que tiene su evolución propia desde 1350 hasta su difusión impresa, y el de lo macabro, que refleja la crisis de conciencia del siglo XV y adquiere «unas dimensiones desconocidas y verdaderamente anormales». En este libro sobre un problema clave como la muerte, apela de modo notable a la iconografía: Tenenti ha recordado que la cultura tradicional, eclesiástica sobre todo, percibió un mayor peligro en la capacidad de reflexión autónoma y de crítica de los hombres de letras, que en las renovaciones radicales de los artistas. Numerosos trabajos de conjunto realizados por él han perseguido una historia global: Los fundamentos del mundo moderno; Florencia en la época de los Medicis; La formación del mundo moderno; El Renacimiento; el primero de ellos estaba firmado con un historiador de su misma generación, R. Romano, estudioso de las relaciones comerciales en la época moderna en Europa y en la América española. Tenenti ha publicado monografías (Venezia e i corsari, 1961, colecciones de artículos (Credence, ideologie, libertinismi tra medioevo ed eta moderna, 1978; Stato: un'idea, una logica. Dal comune italiano all'assolutismo francese, 1987 y editado a clásicos como Il libri della famiglia de L. B. Alberti, 1969. Es también especialista en temas económicos, como el del

  14. Puentes con vigas pretensadas

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    Editorial, Equipo

    1965-07-01

    Full Text Available This paper describes one of the three bridges which Hidrocivil, S. A., has built in Catalonia (northern Spain, over the river Ripoll. The other two bridges are very similar to this one, both in construction and design, and show only minor adjustments to the local topography. The contracting firm proposed several alterations in the prefabrication and constructional procedure, in relation to the initial project, and these changes were accepted. The main feature of these projects is the use of prestressed beams, built at the workshop in sections, and joined together by means of sixty 7 mm cables in each beam. As the shear forces are more acute at the joints, the end of each section has a kind of diaphragm, to provide a large contact area, and hence greater surface to transmit the shear forces. The methods of construction are also of interest. Briefly, they involve building the bridge piles, and use these to support a provisional structure with transversal movement. This provisional structure, in turn, served as platform for two bridge cranes, which lifted the girders to their final location. After the first span was completed, the deck was concreted and the auxiliary structure pushed forward to the next span, to repeat the same operations. This arrangement saved the use of provisional framework.En este trabajo se describe uno de los tres puentes que Hidrocivil, S. A., ha construido.—previo concurso— en la región catalana; concretamente, el que salva el río Ripoll. Los otros dos no han sido objeto de descripción general por ser muy similares, en lo que a ejecución y concepción se refiere, con la única variante que presentan las características topográficas locales. La empresa propuso ciertas variantes— que fueron aceptadas— en la prefabricación y métodos de construcción. El interés de estas obras se centra en el empleo de vigas pretensadas, prefabricadas en taller por trozos, y solidarizados en el mismo mediante las operaciones

  15. Study of Aging and Hepatoprotective Activity of Vitis vinifera L. Seeds in Albino Rats

    Institute of Scientific and Technical Information of China (English)

    Ghulam Mustafa Khan; SH Ansari; ZABhat; Feroz ahmad

    2012-01-01

    Objective: Present study was conducted to investigate in liver of rats from 8-12 weeks old to 20 weeks old, the age dependent changes, carbon tetrachloride mediated changes, and the hepatoprotective effect shown by the seeds of Vitis vinifera L. Method: The hepatoprotective activity was studied by observing the effect of 100 mg/kg dose of ethanolic extract of grape seeds on carbon tetrachloride induced hepatotoxicity in albino rats and results were compared with those of the aged group results. Results: 100 mg/kg b.w. of ethanolic extract of Vitis vinifera seeds produced highly significant decrease in AST, ALT, ALP, bilirubin, albumin levels and significant decrease in the TSP levels compared to the toxic group levels. The levels of AST, ALT, ALP, bilirubin and albumin in aged control rats were found to be significantly higher than the levels in young control animals. MDA levels were slightly higher while GSH levels were lower in aged control rats as compared to young control rats. MDA levels in the toxic group showed highly significant increase compared to the young control levels. Ethanolic extract of seeds of Vitis vinifera significantly lowered the MDA levels. Histopathology results reveal that 100mg/kg/day dose of ethanolic extract of seeds of Vitis vinifera L. cured the hepatic damage to a great extent which was induced by CCl4. Conclusions: Aging leads to the changes in the hepatic structure which are comparable to the changes induced by low doses of a hepatotoxin and the ethanolic extract of seeds of Vitis vinifera L. was effective in bringing about functional improvement of hepatocytes exposed to free radical attack, which was confirmed by biochemical and histological observations.

  16. The Protective Effect of Vitamin C on Irradiated Testes of Albino Rat

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    Lotfy Sayed*, Esam Eldin Abdel Hady*, Hosam Eldin Hussin

    2005-06-01

    Full Text Available The increased exposure to radiation in medicine or industries increases the hazards of radiation on various organs of the human body. The aim of this work was to evaluate the protective effect of anti oxidant (vitamin C against the effect of radiation on rat testes. Thirty adult albino rats were divided into three groups, each contained ten rats .The first group (G.1 was exposed to 415 r (G.1' or 622 r (G.1" using x-ray source for one minute per day for one week. The second group (G.2 was exposed to 415 r (G.2' or 622 r (G.2" using x-ray source for one minute per day for one week, in addition to vitamin C equivalent to 86.9 mg./liter orally for the two sub groups for the same period . The third group (G.3 was a control group. The examined testes of G.1 showed damaged germinal epithelium with remaining some layers of spermatogonia. There was no affection of spermatocytes, mature sperms, Sertoli cells and Leydig cells, the lumen contained little sperms and debris of germ cells (G.1' .While for (G.1" there was marked damage of the seminiferous tubules with irregular outline, destruction of spermatogonia, spermatocytes and spermatids with pyknotic type of nuclear degeneration and the lumen was devoid of mature sperms. The examined testes of the (G.2 showed evidence of almost complete recovery for G .2' and marked recovery for G.2" It is concluded that anti oxidants were essential to patients exposed to x-ray , to guard against its hazards.

  17. EFFICACY OF ANDROGRAPHIS PANICULATA ON ETHYLENE GLYCOL INDUCED NEPHROLITHIASIS IN ALBINO RATS

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    Prathibhakumari P.V.

    2013-06-01

    Full Text Available Nephrolithiasis is the third most common disorder of the urinary system with high recurrence rate. Clinical treatment of lithiasis is costly and can cause harmful side effects and hence nowadays phytotherapy have higher clinical significance in kidney stone management. Aim of the study is to investigate the antilithiatic property of the methanol extract of Andrographis paniculata (MEAP in experimentally induced nephrolithiatic rats. Nephrolithiasis was induced in Wistar albino rats by administering the dose of 0.75% ethylene glycol for a period of 28 days. The experimental animals were divided into nine groups. Group I served as normal control. Group II received standard antilithiatic drug and group III as the lithiatic control. Group IV and V indicated as preventive regime, received 400mg/kg and 200mg/kg body weight MEAP and group VI, VII, VIII and IX indicated curative regime of which VI and IX received 400mg/kg extract and VII and VIII at 200mg/kg body weight of MEAP. At the end of the experimental period, serum (creatinine, blood urea, BUN, uric acid urine (protein, calcium and phosphorus and kidney (calcium and phosphorus were analyzed. All the elevated biochemical parameters in EG received group were declined in the MEAP treated groups at dosage of 200 and 400mg/kg. Urinary protein, phosphorus and calcium also declined in both MEAP treatment groups than the lithiatic groups. Serum creatinine declined significantly in high dose received group than its low dose in both post and co treatment groups. A dose dependent effect was observed in all the serum parameters except BUN. Kidney phosphorus and calcium of preventive regime which received MEAP at a high dose of 400mg/kg showed a clear dose dependent effect than the curative regimes. The result of the present study suggests the usefulness of MEAP against nephrolithiasis.

  18. Effect of curcuma longa L. on fatty liver induced by oxytetracycline in albino rats.

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    Eman G.E. Helal , Samia M. Abd El-Wahab and Ghada A. Zedan

    2011-04-01

    Full Text Available Background: Curcuma longa has been shown to be a potent anti-inflammatory, antioxidant and anticarcinogenic agent. The present investigation aimed at examining the possible potential protective effect of curcuma against oxytetracyclin-induced fatty liver in an attempt to understand its mechanism of action, which may pave the way for possible therapeutic applications. Material and Methods: Albino rats were divided into two major groups, 15 rats for each. The first group was divided into three sub-groups: a control, b fatty liver group; that was injected intraperitonealy with oxytetracycline ( 120mg/kg for three consecutive days resulting in steatosis and c curcuma treated group; which was treated with curcuma ( 0.4 % of diet for 30 days after fatty liver induction . All animals were scarified after 33 days of the beginning of the experiment. The second group was divided into three subgroups: a control, b fatty liver group and c drug protection group; which received curcuma for 15 days before induction of fatty liver, then sacrificed after induction of fatty liver (3 days. Blood samples were collected for biochemical analysis. Liver specimens were obtained and fixed in 10 % formalin for histological study. Results: Fatty liver groups showed high significant increase in serum glucose, cholesterol, triglycerides, LDL cholesterol, ALT, AST, GGT, LDH, total protein, albumin, globulin, urea and creatinine while HDL cholesterol and A/G ratio were significantly decreased compared to control group. Histopathological changes were detected in liver tissue of fatty liver rats. The treatment with curcuma ameliorated the biochemical parameters and histological changes. The pre-treatment with curcuma before the induction of fatty liver also ameliorated the results but they did not turn back to the normal values. Conclusion: It is recommend to using curcuma as diet additive for fatty liver patients or those people who have hyperlipidemic family history.

  19. Impact of dietary oils and fats on lipid peroxidation in liver and blood of albino rats

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    Haggag, Mohammad El-Sayed Yassin El-Sayed; Elsanhoty, Rafaat Mohamed; Ramadan, Mohamed Fawzy

    2014-01-01

    Objective To investigate the effects of different dietary fat and oils (differing in their degree of saturation and unsaturation) on lipid peroxidation in liver and blood of rats. Methods The study was conducted on 50 albino rats that were randomly divided into 5 groups of 10 animals. The groups were fed on dietary butter (Group I), margarine (Group II), olive oil (Group III), sunflower oil (Group IV) and corn oil (Group V) for 7 weeks. After 12 h of diet removal, livers were excised and blood was collected to measure malondialdehyde (MDA) levels in the supernatant of liver homogenate and in blood. Blood superoxide dismutase activity (SOD), glutathione peroxidase activity (GPx), serum vitamin E and total antioxidant capacity (TAC) levels were also measured to determine the effects of fats and oils on lipid peroxidation. Results The results indicated that no significant differences were observed in SOD activity, vitamin E and TAC levels between the five groups. However, there was significant decrease of GPx activity in groups IV and V when compared with other groups. The results indicated that feeding corn oil caused significant increases in liver and blood MDA levels as compared with other oils and fats. There were positive correlations between SOD and GPx, vitamin E and TAC as well as between GPx and TAC (r: 0.743; P<0.001) and between blood MDA and liver MDA (r: 0.897; P<0.001). The results showed also negative correlations between blood MDA on one hand and SOD, GPx, vitamin E and TAC on the other hand. Conclusions The results demonstrated that feeding oils rich in polyunsaturated fatty acids (PUFA) increases lipid peroxidation significantly and may raise the susceptibility of tissues to free radical oxidative damage. PMID:24144131

  20. Selenium ameliorates carbimazole induced hepatotoxicity and oxidative stress in Albino rats

    Institute of Scientific and Technical Information of China (English)

    Saber Abdel-Rahman Sakr; Faten Roshdy Abdel-Ghafar; Samah Mohamed Abo-El-Yazid

    2015-01-01

    Objective:To evaluate the effect of the antithyroid drug, carbimazole on liver of albino rats and the possible ameliorative role of selenium. Methods:Four groups of rats were used (n=10), Group 1 served as normal control, Group 2 was orally given sodium selenite (10μg/kg body weight) daily for 8 weeks, Group 3 was orally given carbimazole at a dose level of 1.35 mg/kg body weight, Group 4 was orally administered carbimazole and sodium selenite daily for 8 weeks. Rats in control and treated groups were sacrificed by cervical decapitation after 8 weeks of treatment, their livers were removed and stained with H&E for histological examinations. Alanine aminotransferase and aspartate aminotransferase were determined in the sera. Malondialdehyde and the antioxidant enzymes, catalase and superoxide dismutase were measured in the liver. Results:Cytoplasmic vacuolation of the hepatocytes, necrosis, leucocytic infiltrations, blood vessels congestion and fatty degeneration were observed in liver of carbimazole-treated animals. Carbimazole caused marked elevation in serum alanine aminotransferase and aspartate aminotransferase. It also caused an increase in malondialdehyde and depletion of the activity of the antioxidant enzymes, catalase and superoxide dismutase in the liver. Treating animals with carbimazole and selenium led to an improvement in both the histological and biochemical alterations induced by carbimazole. Moreover, selenium reduced the level of malondialdehyde and increased the activity of antioxidant enzymes, superoxide dismutase and catalase. Conclusions:It is concluded that the ameliorative effect of selenium against the hepatotoxicity of carbimazole is attributed to its antioxidant properties.