WorldWideScience

Sample records for albinos tratados con

  1. Criptosporidiosis experimental en ratones albinos tratados con Metilprednisolona

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    Hurtado, María del P; Bruzual, Elizabeth; Arcay, Lucila; de la Parte, María A; Brito, Ana

    2010-01-01

    Cryptosporidium spp., es un coccidio intracelular de distribución mundial responsable de un síndrome entérico en el hospedador inmunocompetente e inmunocomprometido. Se estudio la influencia inmunosupresora de la metilprednisolona (MP) en la evolución de la criptoporidiosis experimental en ratones de laboratorio. Se utilizaron dos grupos de cuatro ratones machos jóvenes cada uno; el primer grupo incluyó cuatro ratones infectados y tratados en forma interdiaria con MP a dosis de 16 mg/kg de pe...

  2. Paciente con esquizofrenia tratado con ziprasidona + clozapina

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    Pol Yanguas E.

    2013-05-01

    Full Text Available P es un paciente diagnosticado de esquizofrenia, sigue en un piso tutelado un programa de rehabilitación, está medicado con clozapina 500 mg/día y ziprasidona 280 mg/ día. Padece hipercolesterolemia, tabaquismo y sus hábitos alimenticios no son buenos. La medicación que utiliza desde 2007 hasta ahora se refleja en la tabla 1. El último tratamiento se le introdujo el 7 de agosto de 2012, habiendo presentado un electro cardiograma (ECG normal, pero con ligera taquicardia ventricular y prolactinemia de 44,8 ng/ml (valores normales: 2-18 ng/ml.

  3. Observaciones sobre dos casos de "colitis ulcerativa", tratados con prednisona

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    Luis Valencia Torres

    1960-04-01

    Full Text Available Dos pacientes con colitis ulcerativa fueron tratados con prednisona en una dosis de 30 a 5 mlgr. diarios durante un período de tiempo de cuarenta y cinco días y cuatro meses, respectivamente. Ambos pacientes tenían rayos X de estómago y duodeno negativos, así como cifras de uropepsina normal antes del tratamiento. Ambos presentaron durante el curso del tratamiento episodios epigástricos agudos, con signos radiológicos de gastritis y aumento apreciable en las cifras de uropepsina. Igualmente mejoraron al instalarse un régimen antiulceroso. Un paciente obtuvo cicatrización completa de las ulceraciones y el otro una mejoría apreciable.

  4. Conversazioni autobiografiche con Albino Sacco-Casamassima

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    Orazio Maria Valastro

    2004-03-01

    Full Text Available Nel 1948 venne Olivetti a Matera. Olivetti venne a Matera con un certo ambasciatore americano che praticamente aveva preparato o stava dando una mano per il piano Marschall, venne a Matera e mi vollero incontrare. Io sono stato chiamato dalla piazza, stavo nella piazza, era il mese di luglio, una cosa di questo genere, e andai in un bar, un bar ad angolo mi ricordo in Via Don Minzioni, dove questo Olivetti mi disse 'ma lei che cosa fa coi sassi?' 'Che cos'è questa storia?' Gli raccontai un po' che cosa facevo io con questi amici, avevamo fatto questo, insomma tutto quello che avevamo fatto nei sassi e che volevamo preparare ancora per presentare a qualcuno un piano di revisionamento dei sassi. Mi ricordo, era la prima volta che avevo visto Adriano Olivetti, ne avevo sentito parlare però non avevo mai visto quest'uomo con gli occhi celesti, minuto, coi capelli bianchi, riccioluto, con una cravatta bianca, cosa che mi fece impressione, una specie di angelo.

  5. CON EL TRATADO DE LIBRE COMERCIO PERDIMOS TOD@S

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    Mario Rodríguez

    2008-12-01

    Full Text Available Resumen El objetivo principal de este artículo es analizar la inserción de la economía guatemalteca al proceso del desarrollo global del sistema capitalista. El trabajo sustenta la idea de que la estructura productiva se fue configurando a partir de los procesos de ajuste estructural y que la misma tuvo un sesgo marcadamente neoliberal. Esto permitió generar una plataforma política y económica que facilito la imposición de un modelo dependiente con la instauración de un Acuerdo Comercial con Estados Unidos. Este mecanismo es la última fase de la implantación del modelo económico de acumulación, que permite una inserción del capital nacional al gran mercado capitalista mundial y reconfigura la estructura productiva agrícola del país adaptándola a las nuevas necesidades del capital global.   Abstract The Objective of this article is analyzing the insertion of the Guatemalan economy to process of world development of capitalist system. The work support the idea of the productive structure was forming to begin of structures adjustments process and had a slant markedly neoliberal. It allowed produce a politic platform and economic that made easy the imposition of a dependent model with the establishment of one trade agreement with United States. It mechanism is the last stage of the implantation of economic model of accumulation, that allow a insertion of national working capital to big world capitalist market and reforming the farming productive structure of Guatemala; adjustmenting the country to the new necessities of world working capital.

  6. EL TRATADO DE LIBRE COMERCIO Y SU RELACIÓN CON LA EDUCACION SUPERIOR

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    Pedro Vicente Obando Ordóñez

    2005-01-01

    Full Text Available Colombia se encuentra en el proceso de negociar un Tratado de Libre Comercio con Estados Unidos. La comunidad académica y las organizaciones educativas, a nivel mundial, previenen a los países de los peligros existentes en involucrar a la educación en las negociaciones de tipo comercial. El artículo explica las modalidades en la comercialización de servicios y da ejemplos de la manera como se realizan en el sector de la educación. Se incluye una información general sobre el GATS (Acuerdo General de Comercialización de Servicios en los procesos de negociación del Tratado. Por medio de ejemplos se analizan las barreras que existen en la forma de suministro de servicios educativos. Concluye el artículo con la presentación de cuatro escenarios posibles para la educación en el marco de la globalización.

  7. Esquistossomose mansoni experimental: carga parasitária e distribuição de vermes adultos no sistema porta de ratos albinos tratados com Azatioprina

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    Carlos Alberto Moreira Campos

    1983-09-01

    Full Text Available Estudou-se o curso da infecção esquistossomótica experimental no rato albino, um hospedeiro singular para o Schistosoma mansoni, e quatro semanas após a infecção houve uma rápida diminuição na carga parasitária, fato esse denominado por alguns pesquisadores como ' fenômeno de autocura Contudo, após a administração de um imunossupressor - a Azatioprina - observou-se uma maior susceptibilidade dos ratos à infecção, com os animais apresentando um significativo retardamento no chamado "fenômeno de autocura A grande maioria dos vermes é recuperada nos vasos intra-hepáticos do sistema porta, sem que haja migração para as veias mesentéricas. Quando os ratos foram tratados com Azatioprina observou-se uma significativa localização mesentérica dos vermes adultos neste hospedeiro.The course of experimental Schistosoma mansoni infection in the albino rat, a singular host for schistosomes was studied. Four weeks after infection there was a decrease of worm burden, a sélf-cure phenomenon reported by other investigators. However, after administration of a immunosupressive drug - Azathioprine - an increase in susceptibility of rats to infection was observed, with the animals presenting a significant delay in the to period selfcure. The majority of worms were recovered from the intra-hepatic veins of the portal system, but there was no migration to mesenteric veins. When rats were treated with Azathioprine a significant mesenteric localization of schistosomes was observed in this host.

  8. Esquistossomose mansoni experimental: carga parasitária e distribuição de vermes adultos no sistema porta de ratos albinos tratados com Azatioprina

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    Carlos Alberto Moreira Campos

    1983-09-01

    Full Text Available Estudou-se o curso da infecção esquistossomótica experimental no rato albino, um hospedeiro singular para o Schistosoma mansoni, e quatro semanas após a infecção houve uma rápida diminuição na carga parasitária, fato esse denominado por alguns pesquisadores como ' fenômeno de autocura Contudo, após a administração de um imunossupressor - a Azatioprina - observou-se uma maior susceptibilidade dos ratos à infecção, com os animais apresentando um significativo retardamento no chamado "fenômeno de autocura A grande maioria dos vermes é recuperada nos vasos intra-hepáticos do sistema porta, sem que haja migração para as veias mesentéricas. Quando os ratos foram tratados com Azatioprina observou-se uma significativa localização mesentérica dos vermes adultos neste hospedeiro.

  9. Estabilización de los indicadores hematológicos en paciente con policitemia absoluta secundaria tratado con Vimang

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    Gregorio Martínez-Sánchez

    2009-04-01

    Full Text Available Se reporta un caso del sexo masculino, de 72 años de edad con antecedentes de hipertensión arterial (con un período de evolución de 5 años que fue remitido en el 2001 a la Consulta de Hematología por presentar cifras elevadas de hemoglobina (Hb y hematócrito (Hto. Las cifras elevadas de Hb y Hto se detectaron durante un chequeo médico como resultado de que el paciente presentara pérdida de conocimiento y fuera hospitalizado. El paciente se remitió al Instituto de Hematología e Inmunología (Ciudad de La Habana para realizarle un estudio de volemia y ferrocinética, el cual mostró que presentaba policitemia absoluta moderada. Se descartó policitemia vera y se buscaron causas de policitemia absoluta secundaria sin que hayan encontrado ninguna hasta el presente. Desde este momento el paciente se ha seguido en la Consulta de Hematología del Hospital General Docente Ernesto Che Guevara (Las Tunas y cada 6 meses es chequeado en el Instituto de Hematología e Inmunología, Ciudad de La Habana. A partir del mes de abril de 2004 el paciente recibió 600 mg de Vimang® (extracto de Mangifera indica L. y se incrementó 2 meses después a 900 mg en 3 dosis separadas de 300 mg (tabletas diariamente. El presente estudio analizó la historia clínica del paciente y los resultados de todos los estudios que se le practicaron en los años precedentes al tratamiento con Vimang® y los observados durante el año que estaba bajo tratamiento. Como resultado se observó una reducción en un 50 % del número de flebotomías necesarias para mantener el paciente bajo control con respecto a los valores de Hto y Hb. Se encontraron además diferencias significativas (p < 0,05 con respecto a las desviaciones estándar de los indicadores Hto y Hb, que fueron menores en el periodo en que el paciente fue tratado con el extracto natural.

  10. Selguimiento del peso corporal en pacientes tratados con antipsicóticos: revisión bibliográfica

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    Martín Izquierdo, Marta Estefanía

    2015-01-01

    El tratamiento con antipsicóticos es uno de los principales factores de riesgo que más contribuye a la ganancia de peso en personas con enfermedades mentales graves. Los efectos negativos derivados del sobrepeso y la obesidad, sumados a los propios de la enfermedad, tienen como consecuencia una menor calidad y esperanza de vida en estos pacientes. El objetivo principal de este estudio es realizar una revisión bibliográfica del seguimiento de peso en pacientes tratados con antipsicóticos. ...

  11. Análisis comparativo del sector agropecuario colombiano frente al tratado de libre comercio con Chile

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    Eslava Ardila, Paula

    2014-01-01

    El presente trabajo es un análisis comparativo entre el sector agropecuario de Colombia frente al de Chile, en el marco del Tratado de Libre Comercio, con el objetivo de evaluar los productos potenciales de exportación del sector colombiano, y de esta manera aprovechar los recursos y las ventajas competitivas en oportunidades de progreso. Para el desarrollo del análisis, se describe cada uno de los países en términos económicos con variables como: PIB, PIB per cápita, Balanza Comercial, gr...

  12. Análisis comparativo de morbilidad en grandes quemados tratados con sesiones de autoinjertos frente a cultivo de queratinocitos

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    M. Rubio-Yanchuck

    2015-09-01

    Full Text Available La cobertura rápida y eficaz de las lesiones es un factor limitante en el tratamiento de grandes quemados. Los autoinjertos siguen siendo el tratamiento de elección pero no están exentos de riesgos. El uso de sustitutos de piel cultivada (SPC puede llegar a reducir la morbilidad implícita en el uso de autoinjertos. El objetivo de este estudio es realizar un análisis comparativo de la morbilidad asociada al uso de queratinocitos y autoinjertos en pacientes tratados inicialmente con aloinjertos como cobertura temporal. Realizamos un análisis retrospectivo de morbilidad en 21 pacientes con una superficie corporal quemada (SCQ mayor o igual al 40% en el Hospital Universitario La Paz, Madrid (España entre 2011y 2015. Fueron divididos en 2 grupos según la cobertura definitiva utilizada: un primer grupo con sesiones de autoinjerto, y un segundo grupo con cultivos de queratinocitos y áreas menores de autoinjertos. Fueron 5 mujeres y 16 varones con media de edad de 40,38 años, SCQ del 60,43% y SCQ dérmico profunda-subdérmica del 59,05%. La media de cirugías necesarias en pacientes tratados con autoinjertos y SPC fue 5,36 y 6,7 respectivamente. La incidencia de sepsis fue 80 frente a 50%; el fracaso renal agudo del 63,6 frente al 50%; y de neumonía del 27.3 frente al 40%. Entre los pacientes que sobrevivieron la estancia media en Unidad de Cuidados Intensivos fue de 66,16 frente a 50,6 días, la estancia media hospitalaria fue de 75,6 frente a 63,3 días y la media del número de trasfusiones fue de 75,6 frente a 63.3. La complicación del lecho quirúrgico en el grupo de autoinjertos fue del 63% frente al 0% en los tratados con queratinocitos, y las necesidades medias de noradrenalina fueron de 0,1 frente a 0,03 µg/kg/min. Los pacientes con lecho quirúrgico complicado tuvieron unos requerimientos medios de noradrenalina de 0,117 frente a 0,044 en pacientes con lecho quirúrgico no complicado. Como conclusión, los pacientes tratados con

  13. Estudio prospectivo del funcionamiento cognitivo en pacientes de cáncer de colon tratados con quimioterapia

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    López Santiago, Sonia

    2012-01-01

    El objetivo de esta tesis es investigar los cambios en rendimiento cognitivo de pacientes de cáncer de colon tratados con quimioterapia adyuvante. El método ha sido el estudio longitudinal unifactorial de tres medidas (T1: antes de la quimioterapia, T2: al finalizar el tratamiento y T3 seis meses después de T2); se explora: memoria verbal, función ejecutiva y habilidad psicomotora y variables moduladoras (ansiedad, depresión, astenia y calidad de vida). Muestra: 77 participantes, 63% varones,...

  14. Evaluación clínica y funcional de pacientes con parálisis de Bell tratados con láser

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    Ferrera Montero, Tania; Hernández Zayas, Marcia Sandra; Risset Castro, Liudmila; Castro Correoso, Vivianne

    2015-01-01

    Se realizó una intervención terapéutica, multicéntrica, de 88 pacientes con parálisis de Bell tratados con láser en los servicios de rehabilitación de los policlínicos "Julián Grimau", "Ramón López Peña" y "28 de Septiembre" de Santiago de Cuba, desde enero de 2013 hasta diciembre 2014, para determinar la eficacia de este proceder según la evolución clínica y funcional de los afectados. La muestra aleatoria fue dividida en 2 grupos con 44 integrantes cada uno: los del grupo control recibieron...

  15. Crónica: Un foro sobre el tratado de libre comercio con Estados Unidos: Aspectos jurídicos y económicos

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    Memoria Foro TLC con EEUU

    2004-12-01

    Full Text Available Durantes los días 18 y 19 de agosto de 2004 se realizó en la Universidad ICESI un foro sobre el Tratado de Libre Comercio con Estados Unidos y sus impactos sobre la normatividad jurídica colombiana.

  16. SUSTANCIAS Y REACCIONES QUÍMICAS. TEMAS DEL CURSO DE INGRESO UNIVERSITARIO TRATADOS CON DIFERENTES RECURSOS

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    René O. Güemes

    2011-01-01

    Full Text Available En esta investigación se buscó detectar y comparar dificultades presentadas en la comprensión de los temas “Sustancias” y “Reacciones Químicas” en alumnos ingresantes a la Universidad Nacional del Litoral (Santa Fe, Argentina implementando dos estrategias didácticas diferentes durante el dictado del “Curso de Ingreso de Química”. Se trabajó con dos grupos de alumnos; uno de los grupos utilizó un libro de texto, mientras que el otro trabajó con material multimedia en un aula de informática. Ambos grupos fueron evaluados al inicio y final del curso con la misma evaluación de opciones múltiples. Pudo comprobarse que el grupo que trabajó con el material multimedia alcanzó una mayor comprensión de los conceptos abstractos.

  17. Defectos del dorso nasal tratados con injerto autólogo

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    Ángel Soto Fernández

    2005-08-01

    Full Text Available Se operaron 10 pacientes con defectos del dorso nasal, 9 catalogados de grandes (4 mm o más y uno con menos de 1 mm. En la mayoría predominó el sexo masculino y el defecto fue adquirido. En 9 de los pacientes con defectos grandes se utilizó injerto de hueso de cresta ilíaca en forma de L descansando en huesos propios y espina nasal, y en uno con defecto pequeño se utilizó cartílago. El resultado es evaluado después de 8 años como satisfactorio estética y funcionalmente, sin evidencia clínica de reabsorción.

  18. PREVALENCIA Y FACTORES ASOCIADOS DE LA AUTOMONITORIZACIÓN GLUCÉMICA EN PACIENTES DIABÉTICOS TIPO 2 NO TRATADOS CON INSULINA EN LA COMUNIDAD VALENCIANA

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    Diego Cano-Blanquer; Pedro Cervera-Casino; Salvador Peiró-Moreno; Mónica Mateu-García; Amparo Barreda-Aznar; Grupo de Estudio de la Automonitorización Glucémica

    2013-01-01

    Fundamentos: La utilidad de la automonitorización de la glucemia (AMGS) en pacientes con diabetes tipo 2 (DM2) no tratados con insulina (NTI) es objeto de controversia.. Los objetivos de este trabajo son describir la prevalencia de AMGS en sujetos con DM2 NTI en la Comunidad Valenciana y analizar los factores asociados a su a su uso. Método: Estudio transversal en 83 consultas de atención primaria mediante revisión de la historia clínica electrónica y entrevista a 573 sujetos con DM2-NTI. Se ...

  19. Un caso de osteocondritis costal tífica tratado con vacunas y antivirus

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    Lleras Acosta, F.; Rueda H., Alfonso

    2011-01-01

    Por considerala de importancia práctica, presentamos la historiaclínica de una enferma afectada de osteocondritis costal de origen Eberthiano, tratada con éxito completo por las autovacunas y antivirus, Debemos esta interesante observación al Dr. Juan N. Carpas y al interno de su servicio de mujeres, Sr. Azuero, quienes galantemente nos suministraron los datos clínicos y las observaciones relativas a los efectos producidos por las vacunas.

  20. Un caso de Osteocondritis costal tífica tratado con vacunas y antivirus

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    F. Lleras Acosta

    1932-05-01

    Full Text Available Por considerala de importancia práctica, presentamos la historia clínica de una enferma afectada de osteocondritis costal de origen Eberthiano, tratada con éxito completo por las autovacunas y antivirus, Debemos esta interesante observación al Dr. Juan N. Carpas y al interno de su servicio de mujeres, Sr. Azuero, quienes galantemente nos suministraron los datos clínicos y las observaciones relativas a los efectos producidos por las vacunas.

  1. Poblaciones linfocitarias, células dendríticas y perfil de citoquinas en ratones con melanoma tratados con Uncaria tomentosa

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    Iván Lozada-Requena

    Full Text Available Objetivos. Evaluar el efecto inmunomodulador sobre poblaciones linfocitarias, células dendríticas (DC, citoquinas Th1/Th2/Th17 (T-helper e inflamatorias en el ámbito sistémico y/o en el microambiente tumoral de ratones con o sin melanoma. Materiales y métodos. Se obtuvieron muestras de sangre periférica y/o de tumores primarios de ratones con melanoma B16 tratados o no con un extracto hidroalcohólico de Uncaria tomentosa (UT con 5,03% de alcaloides oxindólicos pentacíclicos (UT-POA obtenido de la corteza de la planta. Todos los ensayos de medición de células y citoquinas fueron realizados por citometría de flujo. Resultados. UT-POA a nivel sistémico incrementa la relación CD4/CD8a (Cluster of Differenciation, mientras que la activación celular es inversamente proporcional; incrementa la proporción de DCm (DC mieloides; induce un perfil Th1 proinflamatorio y reduce la respuesta Th17. TNF-a (tumor necrosis factor alpha y IL-17A (interleuquina correlacionan positiva y negativamente con la relación CD4/CD8a. Conclusiones. El incremento de Th1 (TNF-a puede tener como consecuencia el incremento de linfocitos CD4 o la activación de macrófagos M1. Aunque UT-POA muestra un incremento de DCm, este no es dosis-dependiente. La disminución de Th17 (IL-17A puede favorecer el funcionamiento de los linfocitos CD8a. UT-POA muestra mejores efectos inmunomoduladores en el ámbito sistémico que intratumoral

  2. Factores de riesgo para la recanalización de los aneurismas cerebrales tratados con coils desprendibles

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    Carlos Mario Jiménez Yepes

    2008-11-01

    Full Text Available INTRODUCCIÓN: la efectividad de la embolización con coils de los aneurismas cerebrales se apoya en última instancia en su capacidad para lograr la exclusión del flujo sanguíneo del interior del aneurisma, que a su vez es el mecanismo por medio del cual se previene el resangrado. Los buenos resultados a corto y mediano plazo de la terapia endovascular con coils para la oclusión de aneurismas cerebrales no están discusión, siempre y cuando sean medidos en términos de complicaciones y prevención del resangrado, e incluso son mejores que con cirugía abierta, como lo han demostrado estudios tanto retrospectivos como prospectivos El problema aparece cuando se evalúa la persistencia de la oclusión de los aneurismas a largo plazo. A pesar de las ventajas de la terapia endovascular con coils, los aneurismas embolizados con este método en ocasiones se recanalizan y se requieren intervenciones adicionales, hecho que se constituye en la principal desventaja de esta modalidad de tratamiento. Este fenómeno, llamado recanalización, se ha reportado hasta en, aproximadamente, un tercio de los pacientes. Se han reportado frecuencias de recanalización del 28% en el primer año, 20% entre el primer y segundo años y 14% entre el segundo y tercer años, mostrando un patrón de recanalización que declina progresivamente hasta el tercer año, después del cual ya prácticamente no se presenta. Cognard y colaboradores (Radiology 1999,212;384-356 encontraron una frecuencia de recanalización del 14% en los aneurismas totalmente ocluidos y del 30% en los parcialmente ocluidos, con una frecuencia continua de recurrencia del 5% a los 3 meses, 9% a los 18 meses y 8% a los 38 meses luego de la embolización. En la serie reportada por Hayakawa (J Neurosurgery 2000, 193;561- 568 49% de los aneurismas tratados por medio de coils se hicieron recurrentes debido a recanalización de la luz meses o años después del tratamiento inicial. Como se puede ver a partir

  3. Caracterización de un suelo arcilloso tratado con hidróxido de calcio

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    Carlos Hernando Higuera Sandoval

    2013-02-01

    Full Text Available Propone unametodología para el tratamiento de suelos susceptibles (arcillas mediante la incorporación del hidróxido de calcio como estabilizante, en busca del mejoramiento de sus características físicas, mecánicas y químicas. La caracterización del suelo consistió en la elaboración de una serie de ensayos de laboratorio que determinaran sus características físico-mecánicas y químicas. Además de esto, se diseñaron mezclas de suelo-hidróxido de calcio en las que se varió el porcentaje de aditivo entre el 2% y el 12%, con el fin de observar las tendencias de sus características y poder así seleccionar el porcentaje óptimo de hidróxido de calcio, que proporcionará mejores condicionesde trabajabilidad del suelo estudiado. Como resultado se obtuvo una mezcla que optimizó el comportamiento del suelo original en cuanto a sus propiedades de plasticidad, resistencia y estabilidad, transformando un suelo pobre en uno adecuado para estructuras de pavimentos.

  4. Caracterización de un suelo arcilloso tratado con hidróxido de calcio

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    Óscar Eduardo Pardo Naranjo

    2012-06-01

    Full Text Available Propone una metodología para el tratamiento de suelos susceptibles (arcillas mediante la incorporación del hidróxido de calcio como estabilizante, en busca del mejoramiento de sus características físicas, mecánicas y químicas. La caracterización del suelo consistió en la elaboración de una serie de ensayos de laboratorio que determinaran sus características físico-mecánicas y químicas. Además de esto, se diseñaron mezclas de suelo-hidróxido de calcio en las que se varió el porcentaje de aditivo entre el 2% y el 12%, con el fin de observar las tendencias de sus características y poder así seleccionar el porcentaje óptimo de hidróxido de calcio, que proporcionará mejores condiciones de trabajabilidad del suelo estudiado. Como resultado se obtuvo una mezcla que optimizó el comportamiento del suelo original en cuanto a sus propiedades de plasticidad, resistencia y estabilidad, transformando un suelo pobre en uno adecuado para estructuras de pavimentos.

  5. Evaluación de tiempos quirúrgicos y transfusiones en pacientes quemados tratados con desbridamiento enzimático

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    Ángela Ojeda-Regidor

    Full Text Available Resumen Introducción y Objetivo En los últimos años se han publicado resultados que demuestran un desbridamiento enzimático rápido, eficaz y específico de tejidos quemados con el uso de Nexobrid® (Mediwound, Alemania, producto compuesto por un concentrado de enzimas proteolíticas enriquecidas con bromelaína. En este estudio comparamos el uso de Nexobrid® como desbridante enzimático frente a un Grupo Control con tratamiento estándar, con el objetivo de evaluar; en función de la superficie corporal quemada (SCQ, la cantidad de intervenciones quirúrgicas realizadas, la colonización del lecho quirúrgico, la necesidad de escarotomías, así como los requerimientos transfusionales de los pacientes tratados. Material y Método Estudio retrospectivo con 65 pacientes, edad media de 46.87 años, tratados con Nexobrid® entre septiembre de 2015 y diciembre de 2016. Comparamos con un grupo control de 177 pacientes, edad media de 48.24 años, intervenidos mediante desbridamiento tangencial desde enero a diciembre de 2014. El Grupo Control presenta unas características homogéneas a las del Grupo Nexobrid®. Ambos grupos fueron estratificados en función de su SCQ mayor o menor del 15%. Resultados Encontramos diferencias estadísticamente significativas (p 15%. Los requerimientos transfusionales fueron menores en el Grupo Nexobrid® frente al Grupo Control en los pacientes con SCQ > 15% (p 15%. Finalmente, reduce la necesidad de transfusión sanguínea en pacientes con SCQ mayor del 15%.

  6. Viabilidad de la aplicación de materiales reciclados y cenizas de biomasa en la fabricación de materiales tratados con cemento

    OpenAIRE

    Cabrera Montenegro, Manuel

    2016-01-01

    La presente Tesis Doctoral es una contribución al conocimiento y la investigación sobre el uso de áridos reciclados y cenizas de fondo procedentes de la combustión de biomasa para su uso en ingeniería civil. El interés en el uso de áridos reciclados procedentes de residuos de construcción y demolición (RCD) están en continuo crecimiento debido a su potencial frente a diversos usos, entre ellos como material tratado con cemento para capas estructurales de carretera. Por ot...

  7. Implicaciones para el Ecuador del Tratado de Libre Comercio con Estados Unidos en relación a los medicamentos y a la salud.

    OpenAIRE

    Logroño Barrionuevo, Milton Efraín

    2006-01-01

    1. LEGISLACION DE PROPIEDAD INTELECTUAL 2.EL TRATADO DE LIBRE COMERCIO: MEDICAMENTOS Y SALUD 3. IMPACTO DEL TRATADO DE LIBRE COMERCIO EN MEDICINAS Y SALUD.4. IMPLICACIONES SOCIALES DEL TRATADO DE LIBRE COMERCIO EN MEDICAMENTOS Y SALUD 5. PROPUESTA DE NEGOCIACIÓN EQUITATIVA DEL ECUADOR EN EL TRATADO DE LIBRE COMERCIO EN MEDICAMENTOS Y SALUD.6. CONCLUSIONES Y RECOMENDACIONES

  8. Comportamiento detersivo de las formulaciones ecológicas en la extracción de grasas y proteínas en tejido de algodón aprestado y tratado con diversos suavizantes

    OpenAIRE

    Carrión Fité, Francisco Javier; Serra Gasol, Miquel

    2002-01-01

    En el presente trabajo se efectuó un estudio del comportamiento detersivo producido por una formulación ecológica, aplicada para el lavado de un tejido de algodón aprestado con una resina DMDHEU y tratado con diferentes suavizantes catiónicos, del tipo de amonio silicona y esterquat. A estos tejidos se aplicaron, antes del lavado, dos impurezas del tipo proteína y una tipo aceitosa. Los efectos del detergente, en la extracción de tales impurezas del tejido aprestado y tratado con los diferent...

  9. EVALUACIÓN DEL MANEJO TUBULAR DEL POTASIO EN PACIENTES CIRRÓTICOS TRATADOS CON COMBINACIÓN DE FUROSEMIDA + ESPIRONOLACTONA

    Directory of Open Access Journals (Sweden)

    Algranati L

    2011-01-01

    Full Text Available Los cirróticos desarrollan hiperaldosteronismo secundario en estadios avanzados de su enfermedad, requiriendo tratamiento con furosemida + espironolactona. El manejo tubular del potasio (K en estos pacientes bajo dicho esquema diurético combinado (antagónico no ha sido aun estudiado, por lo cual decidimos describir el valor de la excreción fraccional (EF de potasio y del gradiente transtubular de potasio (GTTK en esta población bajo dichos diuréticos. Material y Método: Se evaluó prospectivamente la EF de sodio (Na, EFK y GTTK en 18 pacientes (11 hombres, edad promedio 56 años, normokalémicos, cirróticos (Ci compensados estadios Child Pugh A, B y C, MELD medio 22, portadores de filtrado glomerular, sedimento urinario y ecografía renal normales, tratados con furosemida + espironolactona y dieta hiposódica. Grupo control: 10 voluntarios sanos bajo igual dieta (S. Análisis estadístico: Wilcoxon. Resultados: Kalemia (mmol/l: 4 ± 0.5 (Ci vs. 4 ± 0.3 (S, p=NS; EFNa (%: 0.8 ± 0.4 (Ci vs. 0.5 ± 0.3 (S p=NS; EFK (%: 9.1 ±3 (Ci vs. 10±2 (S, p=NS; GGTK: 6 ±2 (Ci vs. 4 ±1 (S, p=0.04. Conclusión: Observamos que en cirróticos tratados con furosemida + espironolactona, existe un incremento significativo de la excreción urinaria de potasio, sólo evidenciable por el GTTK.

  10. Avaliação de parâmetros antioxidantes em ratos tratados com sevoflurano Evaluación de parámetros antioxidantes en ratones tratados con sevoflurano Evaluation of antioxidant parameters in eats treated with sevoflurane

    Directory of Open Access Journals (Sweden)

    Francisco J. L Bezerra

    2010-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O sevoflurano é um éter halogenado com flúor que sofre biotransformação hepática através do citocromo P450 2E1. Éteres halogenados que sofrem biotransformação pelo P450 2E1 podem produzir espécies reativas do oxigênio (ERO e promover enfraquecimento do sistema de defesa antioxidante. O objetivo deste trabalho foi investigar a relação entre a atividade das enzimas antioxidantes eritrocitárias e o sevoflurano. MÉTODO: Os animais foram distribuídos em quatro grupos: Grupo 1 controle: apenas oxigênio a 100% (1 L.min-1 por 60 minutos durante 5 dias consecutivos; Grupo 2 - sevoflurane 4,0% em oxigênio a 100% (1 L.min-1 por 60 minutos durante 5 dias consecutivos; Grupo 3 - isoniazida (i.p., 50 mg.kg-1 de peso corporal /dia, durante 4 dias e em seguida tratados apenas com oxigênio a 100% (1 L.min-1 por 60 minutos durante 5 dias consecutivos; Grupo 4 - isoniazida por via intraperitoneal na dose de 50 mg.kg-1 de peso corporal, diariamente durante 4 dias, seguido da administração do sevoflurane a 4,0% em oxigênio a 100% (1 L.min-1 por 60 minutos durante 5 dias. Após 12 horas da última exposição ao sevoflurane, os animais foram sacrificados e o sangue foi coletado através da veia porta para análise da atividade das enzimas antioxidantes. RESULTADOS: Aumento da atividade específica da glicose-6-fosfato desidrogenase, diminuição da atividade específica da catalase, principalmente no grupo de animais pré-tratados com isoniazida e, em seguida, tratados com sevoflurano. A glutationa peroxidase não apresentou alteração na sua atividade. CONCLUSÕES: A interação do sevoflurano com indutores enzimáticos do citocromo P450 2E1 pode propiciar a instalação do estresse oxidativo caso a exposição se torne prolongada e repetitiva.JUSTIFICATIVA Y OBJETIVOS: El sevoflurano es un éter halogenado con flúor que sufre una biotransformación hepática a través del citocromo P450 2E1. Los

  11. Función adrenal y metabolismo lipídico en niños asmáticos tratados con budesonida

    Directory of Open Access Journals (Sweden)

    Paoli-de Valeri Mariela

    1999-01-01

    Full Text Available Objetivo. Evaluar el efecto de bajas dosis de budesonida inhalado sobre la función adrenal y el metabolismo lipídico en niños asmáticos. Material y métodos. Se estudiaron: 10 niños asmáticos (edad promedio, 8.6 años tratados con budesonida inhalado (200-300 µg/día por un lapso mayor a tres meses (grupo A; 15 niños asmáticos (edad promedio, 7.8 años sin tratamiento esteroideo (grupo B, y 10 niños no asmáticos (grupo C. Se determinaron los niveles de cortisol basal y postestímulo con ACTH, andrógenos adrenales, lípidos y cortisol urinario. Resultados. Entre los grupos A y B no hubo diferencias significativas en las variables estudiadas. En los niños asmáticos (grupo A-B el cortisol urinario fue significativamente mayor en relación con el grupo C. Los niveles de triglicéridos, colesterol total, colesterol de la lipoproteína de baja densidad e índices aterogénicos fueron mayores en el grupo de niños asmáticos, con y sin budesonida, comparados con el grupo C. Conclusiones. El tratamiento con dosis bajas de budesonida inhalado en niños asmáticos no modificó la función del eje adrenal ni el metabolismo lipídico. Los pacientes asmáticos presentaron un perfil lipídico aterogénico que podría incrementar el riesgo de enfermedad cardiovascular.

  12. PREVALENCIA Y FACTORES ASOCIADOS DE LA AUTOMONITORIZACIÓN GLUCÉMICA EN PACIENTES DIABÉTICOS TIPO 2 NO TRATADOS CON INSULINA EN LA COMUNIDAD VALENCIANA

    Directory of Open Access Journals (Sweden)

    Diego Cano-Blanquer

    2013-01-01

    Full Text Available Fundamentos: La utilidad de la automonitorización de la glucemia (AMGS en pacientes con diabetes tipo 2 (DM2 no tratados con insulina (NTI es objeto de controversia.. Los objetivos de este trabajo son describir la prevalencia de AMGS en sujetos con DM2 NTI en la Comunidad Valenciana y analizar los factores asociados a su a su uso. Método: Estudio transversal en 83 consultas de atención primaria mediante revisión de la historia clínica electrónica y entrevista a 573 sujetos con DM2-NTI. Se analizó la asociación entre la indicación de AMGS y las características del paciente, médico y organizativas. Resultados: 289 (50,4% de los pacientes con DM2-NTI utilizaban AMGS. En el análisis multivariante el uso de AMGS se asoció a la menor edad (OR:2,3 para 65-84 y 6,0 para 8, vs <7, número de antidiabéticos orales prescritos (ADO (OR:2,5, 4,1 y 5,7 para 1, 2 ó 3+ ADO vs no tratamiento farmacológico, tipo de ADO (mayor en sulfonilureas y glitazonas y enfermedad respiratoria crónica (OR:0,5. Controlando el efecto de estos factores, el uso de AMGS se asoció adicionalmente a los años de ejercicio profesional del médico y a la asistencia en algunos departamentos sanitarios. Conclusiones: La mitad de los pacientes con DM-NTI utilizan AMGS. Su uso se asoció fuertemente a las características clínicas de los pacientes, aunque algunos factores no clínicos explican parte de la variabilidad en su utilización.

  13. La importancia de una estrategia de comercializaci?n y negociaci?n del sectorfloricultor colombiano en el marco del Tratado de Libre Comercio (TLC) con losEstados Unidos

    OpenAIRE

    Vargas Su?rez, Carlos Andr?s

    2005-01-01

    Por esto, la intenci?n de esta investigaci?n es plantear una estrategia de comercializaci?n y negociaci?n para el sector floricultor colombiano m?s acorde, que le haga frente a esta nueva oportunidad que se le presenta al pa?s, como lo es el Tratado de Libre Comercio con Estados Unidos.

  14. Adenocarcinoma de recto y ano en paciente con enfermedad de Crohn tratado con infliximab Adenocarcinoma of the rectum and anus in a patient with Crohn´s disease treated with infliximab

    Directory of Open Access Journals (Sweden)

    J. Egea Valenzuela

    2010-08-01

    Full Text Available In the present paper, we report the case of a patient with long-standing Crohn´s disease and multiple complications that, after receiving treatment with infliximab, was diagnosed with an adenocarcinoma of the rectum and anus that required radical surgery, later presenting multiple metastases. In the discussion, characteristics and major risk factors for colorectal cancer in patients with inflammatory bowel disease will be largely reviewed, and current studies will be analyzed in connection with the appearance of neoplasms in patients being treated with biologics.Presentamos el caso de un paciente con enfermedad de Crohn de larga evolución y con múltiples complicaciones de su enfermedad que, tras recibir tratamiento con infliximab, es diagnosticado de un adenocarcinoma de recto y ano que precisa cirugía radical, presentando posteriormente metástasis múltiples. Se repasarán durante la discusión las características y los factores de riesgo más importantes del cáncer colorrectal en pacientes con enfermedad inflamatoria intestinal, y se analizarán los trabajos existentes hasta la fecha en relación con la aparición de neoplasias en pacientes tratados con fármacos biológicos.

  15. Rabdomioma cardiaco tratado quirúrgicamente con éxito y revisión de la literatura

    OpenAIRE

    Cigarroa López,Ángel; García Jiménez,Yoloxóchitl; Yáñez Gutiérrez,Lucelly; Jiménez Arteaga,Santiago; Martínez Sánchez,Arturo; Ortegón Cardeña,José; David Gómez,Felipe; Sánchez Soberanes,Agustín; López Gallegos,Diana; Riera-Kinkel,Carlos; Alva Espinosa,Carlos

    2005-01-01

    Los tumores cardiacos primarios son raros, con incidencia variable en todas las edades del 0.005 al 0.05%. En pacientes pediátricos, la incidencia es del 0.27%. Los tumores más frecuentes durante la infancia son los rabdomiomas cardiacos, considerados como benignos. Aunque la expresión clínica es amplia, en la mayoría de los casos son asintomáticos y se detectan por la presencia de soplos. En la etapa prenatal se manifiestan con arritmias o hydrops fetalis. En algunos neonatos y lactantes se ...

  16. Prevalencia y factores asociados de la automonitorización glucémica en pacientes diabéticos tipo 2 no tratados con insulina en la Comunidad Valenciana

    OpenAIRE

    Cano-Blanquer, Diego; Cervera-Casino, Pedro; Peiró-Moreno, Salvador; Mateu-García, Mónica; Barreda-Aznar, Amparo

    2013-01-01

    Fundamentos: La utilidad de la automonitorización de la glucemia (AMGS) en pacientes con diabetes tipo 2 (DM2) no tratados con insulina (NTI) es objeto de controversia. Los objetivos de este trabajo son describir la prevalencia de AMGS en sujetos con DM2 NTI en la Comunidad Valenciana y analizar los factores asociados a su a su uso. Método: Estudio transversal en 83 consultas de atención primaria mediante revisión de la historia clínica electrónica y entrevista a 573 sujetos con DM2-NTI. Se a...

  17. Oxidation kinetics of hazelnut oil treated with ozone; Cinética de oxidación del aceite de avellana tratado con ozono

    Energy Technology Data Exchange (ETDEWEB)

    Uzun, H.; Ibanoglu, E.

    2017-07-01

    libres de todas las muestras. Ea y ΔH‡ de los aceites tratados con ozono mostraron una tendencia reductora que refleja una mayor sensibilidad a la oxidación de los aceites después del tratamiento con ozono. Consistentemente, un aumento de ΔS‡ indicó una reacción de oxidación más rápida con un aumento del tiempo de exposición al ozono. Sin embargo, no se observó diferencia significativa en k, Ea, ΔH‡, ΔS‡ (p <0.05) en función del período de almacenamiento, después de que el aceite de avellana fue tratado con ozono durante 1 min.

  18. Recuperación del epitelio germinal masculino de ratones tratados con dosis única de Busulfán

    Directory of Open Access Journals (Sweden)

    Luis Guzmán

    2013-05-01

    Full Text Available Busulfán es un agente alquilante bifuncional tipo-éster, que interfiere con la replicación del ADN. Dosis elevadas de este compuesto son aplicadas antes de los transplantes de médula ósea y de células germinales, sin embargo no han sido cuantificados el daño ni la recuperación del sistema reproductor. Para cuantificar la recuperación del efecto en la espermatogénesis, se usaron ratones de la cepa Balb C, a los que se les inyectó Busulfán intraperitonealmente, 40 mg/kg de peso corporal, y se evaluó el peso testicular y la concentración espermática en cola de epidídimo, a los 30, 54 y 72 días y se realizaron cortes histológicos de testículo. Los resultados fueron analizados con la prueba U Mann-Whitney p>0.05. A los 30 días el peso testicular, la concentración espermática y el diámetro de los túbulos seminíferos presentaron una drástica reducción del 77,8%, 97,9% y 34,3% respectivamente, comparados con el grupo control. A los 54 días, el peso testicular y el diámetro testicular muestran una recuperación del 70%. A los 72 días, la recuperación es completa en los parámetros evaluados. Por lo tanto, Busulfán aplicado en una sola dosis afecta significativamente la espermatogénesis en el ratón y se logra la recuperación completa en dos ciclos espermáticos.

  19. ¿Mejora la calidad de vida de pacientes con EPOC si son tratados por las enfermeras?

    OpenAIRE

    Vega Ramírez, Francisco Antonio; Quero Fuentes, María del Mar

    2015-01-01

    Cartel presentado en la Segunda Conferencia Internacional de Comunicación en Salud, celebrada el 23 de octubre de 2015 en la Universidad Carlos III de Madrid Introducción: la enfermedad pulmonar obstructiva crónica (EPOC), afecta a la calidad de vida (CV) de las personas y origina la necesidad de acciones adicionales de autocuidado. Objetivo: conocer si existe mejora en la calidad de vida en los pacientes con EPOC que son atendidos por enfermeras. Metodología: este estudio se basa en un di...

  20. Durabilidad de un suelo contaminado y tratado con cemento portland Durability of a contaminated soil treated with portland cement

    OpenAIRE

    José W Jiménez Rojas; Nilo C Consoli; Karla Salvagni Heineck

    2008-01-01

    Este trabajo tiene por objetivo la aplicación de la técnica de solidificación/estabilización de suelos contaminados, analizando específicamente el comportamiento físico del suelo a través de ensayos de durabilidad. El suelo fue contaminado en laboratorio con residuo oleoso y la aplicación de la técnica tuvo cómo agente de encapsulamiento el cemento Portland CP V-ARI. Los ensayos de durabilidad, realizados según la NBR 13554 (1996), tuvieron como objetivo estudiar el grado de desagregación y v...

  1. Evaluación clínico-citológica del herpes labial tratado con láser

    Directory of Open Access Journals (Sweden)

    Teresa García Sánchez,

    2001-08-01

    Full Text Available Se realizó un estudio descriptivo, longitudinal y prospectivo consistente en la descripción citológica y clínica de las muestras obtenidas en 150 pacientes con herpes labial diagnosticadas y atendidas en las diferentes consultas, que reunieron criterios de inclusión objetivos y subjetivos. Las muestras obtenidas por raspado de la superficie afectada se fijaron con cytospray y se colorearon con el método de Papanicolau; fueron leídas al inicio y a las 48 horas para evaluar la recuperación de la mucosa bajo los efectos del láser infrarrojo de arsenurio de galio y aluminio en dosis de 0,6 J/cm2 durante 1 minuto, para un total de 2 a 3 sesiones. Las células intermedias de las mucosas mostraron el mayor nivel de multiplicación, la recuperación fue identificada a partir de las 48 horas de evaluación citológica, clínicamente al 4to. día. Se recomienda evaluar la eficiencia del nuevo esquema terapéutico con láser para esta afección, así como su costo y efectividad.A descriptive, longitudinal and prospective study consisting in the cytological and clinical description of the samples obtained in 150 patients with herpes labialis diagnosed and seen in different consultation rooms was conducted. Objective and subjective inclusion criteria were gathered. The samples of the affected surfaces obtained by curettage were fixed with cytospray and they were colored by using Papanicolau’s method. They were read at the beginning and 48 hours later to evaluate the recovery of the mucosa under the effects of the infrared laser of gallium and alluminum arsenide at doses of 0.6 J/cm3 during a minute for a total of 2 or 3 sessions. The intermediate cells of the mucosas showed the highest level of multiplication. The recovery was identified 48 hours after the cytologic evaluation and from the clinical point of view on the 4th day. It was recommended to evaluate the efficiency of the new therapeutic scheme with laser to treat this affection, as well

  2. Análisis de la producción y comercialización del banano, su aceptación y evolución frente al Tratado de Libre Comercio con la Unión Europea

    OpenAIRE

    Rojas, Miguel Angel; Rodríguez, María Vanessa

    2015-01-01

    Colombia ha sido tradicionalmente un país exportador de banano, incluso éste producto es uno de los que conforman la canasta de los tradicionales. Ahora bien, con el Tratado de Libre Comercio con la Unión Europea es factible que su posición mejore en este mercado de más de 500 millones de habitantes, sin embargo, y bajo el supuesto que a futuro Ecuador ( el primer productor mundial) y Costa Rica suscriban TLC´S con la Unión Europea . El país ha emprendido una etapa de transformación que ...

  3. Estandarización de una prueba de ELISA para detectar anticuerpos IgE en pacientes con equinococosis quistica y su utilidad en el diagnóstico y seguimiento de pacientes tratados con albendazol: reporte preliminar

    Directory of Open Access Journals (Sweden)

    Herman Vildózola

    2012-01-01

    Full Text Available Objetivos: Determinar las diluciones y concentraciones optimas de una prueba de ELISA para detectar anticuerpos IgE, así como su sensibilidad, espécificidad y valor predictivo en pacientes con equinococosis quistica. Analizar si los niveles de anticuerpos IgE especificos se correlacionan con la respuesta al tratamiento médico con albendazol en un periodo mayor a un año de finalizado el tratamiento. Diseño: Estudio cuasiexperimental con grupo control. Institución: Instituto de Medicina Tropical Daniel A. Carrión, Facultad de Medicina, UNMSM, Lima, Perú. Material de estudio: Prueba de ELISA para anticuerpo IgE. Intervenciones: Estandarizacion de la prueba de ELISA para anticuerpo IgE y diseño preexperimento con preprueba y posprueba en un solo grupo, para evaluar su valor en el diagnóstico y seguimiento postratamiento de pacientes con quiste hidatidico hepatico tratados con albendazol. Para la estandarizacion de la prueba de ELISA, se utilizó suero de cinco pacientes con diagnóstico clínico de equinococosis quistica, y la sensibilidad y especificidad de la prueba se usó suero de 30 pacientes aparentemente sanos. Para determinar las reacciones cruzadas, se utilizó 16 muestras de suero de pacientes con otras helmintiasis (ascariasis, strongiloidiasis, toxocariosis, trichuriasis, himenolepiasis, cisticercosis y teniasis. Para el diagnóstico y seguimiento postratamiento de equinocococosis quística, se utilizó el suero de 17 pacientes. Principales medidas de resultados: Sensibilidad y especificidad de prueba estandarizada de ELISA para detectar anticuerpos IgE. Resultados: La prueba estandarizada de ELISA para detectar anticuerpos IgE tuvo una sensibilidad de 95,6% y una especificidad de 100%. En los pacientes con quiste hidatídico hepático considerados curados, uniformemente disminuyeron los niveles de anticuerpo tipo IgE hasta la negativización. Se obtuvo elevación de los niveles de IgE en los pacientes que presentaron

  4. Durabilidad de un suelo contaminado y tratado con cemento portland Durability of a contaminated soil treated with portland cement

    Directory of Open Access Journals (Sweden)

    José W Jiménez Rojas

    2008-01-01

    Full Text Available Este trabajo tiene por objetivo la aplicación de la técnica de solidificación/estabilización de suelos contaminados, analizando específicamente el comportamiento físico del suelo a través de ensayos de durabilidad. El suelo fue contaminado en laboratorio con residuo oleoso y la aplicación de la técnica tuvo cómo agente de encapsulamiento el cemento Portland CP V-ARI. Los ensayos de durabilidad, realizados según la NBR 13554 (1996, tuvieron como objetivo estudiar el grado de desagregación y vulnerabilidad del material con diversas combinaciones de dosificaciones de cemento y residuo oleoso, así cómo estudiar la variación volumétrica de los mismos. A partir de los resultados es posible observar que cuanto mayor la cantidad de contaminante, mayor es la pérdida de masa. Sin embargo, cuánto mayor es la cantidad de cemento, menor es la pérdida de masa y menor la variación volumétrica.This work seeks the application of solidification/stabilization techniques to contaminated soils analyzing specifically de physical behavior of the soil through tests of durability. The soil was contaminated in laboratory with acidic oily sludge industrial residues and the application of that technique had an encapsulate agent, the Portland cement CP V-ARI. The tests were carried out according to NBR 13.554 (1996, and they aimed to study the level of degradation and the vulnerability of the material with several combinations of cement and acidic oily sludge as well as study their volumetric variations. Starting from the results, it is possible to observe that the larger the contamination the larger the mass loss; however the larger the amount of cement, the smaller the mass loss and the more stable the volumetric variation.

  5. Evolución oftalmológica en pacientes hipertiroideos tratados con yodo radiactivo Ophthalmological evolution in hyperthyroid patients treated with radioactive iodine

    Directory of Open Access Journals (Sweden)

    María Teresa Marrero Rodríguez

    2005-08-01

    Full Text Available El objetivo del presente estudio fue realizar un análisis de la evolución oftalmológica en pacientes hipertiroideos tratados con yodo radiactivo. Se estudiaron 100 casos (88 mujeres y 12 hombres procedentes de la consulta de tiroides del Instituto Nacional de Endocrinología, con diagnóstico clínico y bioquímico de hipertiroidismo y con una edad media de 40 ± 10 años. Estos pacientes fueron sometidos a un tratamiento con yodo radiactivo a una dosis de 80 µCi/g de tejido tiroideo. A cada uno de ellos se le realizó una oftalmometría bilateral antes del tratamiento y 12 meses después de este. La oftalmometría media del ojo derecho antes del tratamiento fue de 14,51 ± 2,86 mm y posterior al tratamiento de 13,92 ± 2,83 mm, mientras que para el ojo izquierdo fue de 14,98 ± 2,91 mm y 14,27 ± 2,83 mm, respectivamente. Teniendo en cuenta los resultados de la oftalmometría, concluimos que el uso del yodo radiactivo en el tratamiento de pacientes hipertiroideos no tuvo efectos negativos sobre la evolución oftalmológica de los pacientes estudiados.This study was aimed at analyzing the ophthalmolgical evolution in hyperthyroid patients treated with radioactive iodine. 100 patients (88 females and 12 males from the thyroid department of the National Institute of Endocrinology with clinical and biochemical diagnosis of hyperthyroidism and with a mean age of 40 ± 10 years old, were studied. These patients underwent a treatment with radioactive iodine at a dose of 80 m Ci/g of thyroid tissue. A bilateral ophthalmometry was performed to each patient before the treatment and 12 months after it. Mean ophthalmometry of the right eye was 14.51 ± 2.86 mm before the treatment and 13.92 ± 2.83 mm after the treatment, whereas for the left eye it was 14.98 ± 2.91 mm and 14.27 ± 2.83 mm , respectively. Taking into account the results of the ophthalmometry, we concluded that the use of radioactive iodine in the treatment of hyperthyroid patients had

  6. Estimación de la conductividad hidráulica saturada in situ en un suelo tratado con vinaza

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    Ludwig M Rojas D

    2008-06-01

    Full Text Available Se estimaron los cambios en la conductividad hidráulica saturada mediante las técnicas de caída de carga" y "fuente localizada de agua en un suelo Ustipsamment típico arenoso isohipertérmico con dosis diluidas de vinazas. La investigación se realizó en el centro experimental de la Universidad Nacional de Colombia Sede Palmira (3° 25'39.81" N y 76° 25'45.70" o, 953 m.s.n.m, 24 °C y 60% HR, 1.020 mm. Los dos métodos no difirieron de forma significativa (p<0.05 en la estimación de la conductividad hidráulica saturada promedio, la cual se redujo de forma exponencial al incrementar la concentración de vinaza. Los resultados obtenidos nos indican una reducción de la conductividad hidráulica del 50% para una concentración de vinaza de 2° Brix en un suelo arenoso, 5.3° Brix en el suelo franco arenoso y 6.1° Brix en el suelo franco arcilloso.

  7. Factores pronósticos y predictivos de respuesta en pacientes con carcinoma de vejiga localmente avanzado tratados con quimioterapia neoadyuvante

    OpenAIRE

    Céliz, Pamela

    2012-01-01

    La cistectomía radical es el tratamiento de elección en pacientes con carcinoma de vejiga localmente avanzado. Sin embargo, más del 50% de los pacientes presentan recurrencias y fallecen por la enfermedad. La quimioterapia neoadyuvante ha demostrado un beneficio modesto en estos pacientes, más significativo en pacientes con respuesta patológica completa tras el tratamiento. Sin embargo, aun no se ha identificado en que pacientes se obtiene un mayor beneficio. El análisis de genes que particip...

  8. Respuesta clínica en pacientes mexicanos con síndrome de intestino irritable tratados con dieta baja en carbohidratos fermentables (FODMAP

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    N. Pérez y López

    2015-07-01

    Conclusiones: En este primer estudio en población mexicana con SII se observó mejoría significativa de los principales síntomas incluyendo dolor, distensión y flatulencia tras una dieta baja FODMAP.

  9. Síndrome de lisis tumoral en un paciente con cáncer de riñón tratado con sunitinib

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    Ezequiel Rodríguez-Reimúndes

    2011-04-01

    Full Text Available El síndrome de lisis tumoral (SLT es un trastorno metabólico que ocurre como consecuencia de una destrucción celular masiva. Se caracteriza por la presencia de hiperuricemia, hiperfosfatemia, hipocalcemia e hiperkalemia, y predispone al desarrollo de insuficiencia renal aguda. En la mayoría de los casos el SLT ocurre luego de instaurarse un tratamiento antitumoral y es más frecuente en tumores de alto grado de malignidad y alta sensibilidad a la quimioterapia. Presentamos el caso de un paciente con diagnóstico de cáncer de riñón recidivado que presenta un SLT e insuficiencia renal aguda luego de iniciar tratamiento con sunitinib.

  10. Desarrollo de panuveítis por tuberculosis en paciente con esclerosis múltiple tratado con interferón beta

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    Lucía Echevarría Lucas

    2016-09-01

    Los linfocitos CD4+ T, leucocitos, macrófagos y granulocitos, con la producción de sus mediadores interferón gamma, IL-12 o TNF-α son fundamentales para controlar al Mycobacterium tuberculosis. Por ello, antes de introducir Interferón beta 1b, convendría realizar técnicas de screening, como la prueba de Mantoux o el interferon gamma release assay–(quantiferon-TB para detectar posibles tuberculosis latentes potencialmente activables.

  11. CUANTIFICACIÓN DE MERCURIO EN PASTO TRATADO CON BIOSÓLIDOS POR ESPECTROFOTOMETRÍA DE ABSORCIÓN ATÓMICA CON GENERADOR DE HIDRUROS

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    Amilvia Yanett Ortiz Villa

    Full Text Available Los subproductos sólidos de carácter orgánico generados por los procesos de tratamiento de aguas residuales municipales son utilizados comúnmente como fuente de nutrientes para tratamiento de suelos. Estos biosólidos contienen nutrientes contaminantes inorgánicos como el mercurio, el cual es empleado para el estudio, por el conocimiento ampliamente documentado de su toxicidad en sistemas vivos y sus efectos en seres humanos. En este mismo sentido, y puesto que las plantas constituyen la base de la cadena trófica, se centra la atención sobre el pasto, debido a su fácil crecimiento y uso como pastura de ganadería. El mercurio en pasto fue cuantificado mediante espectrofotometría de absorción atómica utilizando la técnica de generador de hidruros con vapor frío. Se verificaron algunos parámetros de validación con criterios de aceptación deseables tales como linealidad (r² = 0,999, exactitud (R = 93,14-96,12%, precisión (CV = 1,11-1,69%, límites de detección y cuantificación (0,001-0,003 ppb. Se evidenció que las concentraciones de mercurio se encuentran por debajo de los valores máximos permitidos por la normatividad Internacional, presentando el biosólido como fuente confiable de nutrientes para el agro. De esta forma se establece una metodología que puede ser una buena herramienta para la determinación analítica de mercurio en pastos.

  12. Evolución electrofisiológica en pacientes con síndrome del túnel del carpo tratados con cirugía

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    Enrique Vergara Amador

    2016-01-01

    Conclusiones. La mejoría de los parámetros electrofisiológicos después de una liberación de síndrome de túnel del carpo es controversial: algunos reportes muestran mejoría desde el primer mes, especialmente en la velocidad de conducción sensitiva. Otros estudios muestran mejoría significativa entre las semanas 18 y 42 postoperatorias, siendo la recuperación motora más rápida que la sensitiva. En el presente estudio el 52% de los pacientes mejoraron en las escalas por disminución del grado de severidad. Las latencias distales motoras y sensitivas y el delta sensitivo del nervio mediano evidenciaron una mejoría. Estos resultados sugieren que los estudios electrodiagnóstico son efectivos en la evaluación objetiva de pacientes con síndrome de túnel del carpo y es el único examen que puede demostrar mejoría luego de una liberación del STC.

  13. Doctor Octavio Montoro y los primeros casos de diabetes tratados con insulina en Cuba Doctor Octavio Montoro and the first cases of diabetes treated with insulin in Cuba

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    Dagoberto Álvarez Aldana

    2003-08-01

    Full Text Available El uso clínico de la insulina por Banting y Best representa un hito en la historia de las ciencias médicas. Los avances en este campo han sido espectaculares y nuestro país no está ajeno a ellos. Sin embargo, poco se conoce sobre los primeros trabajos realizados por los médicos cubanos en relación con la insulinoterapia, hecho trascendental en la historia de la endocrinología cubana, pero desconocido principalmente para las nuevas generaciones de endocrinólogos. Esta revisión tiene como objetivos destacar la introducción en la clínica moderna de la insulina como un importante suceso en la historiografía médica cubana y divulgar la evolución clínica y el esquema terapéutico aplicado a los primeros casos de diabetes mellitus tratados con insulina en Cuba, así como resaltar el empeño y la capacidad de los profesionales de la salud pioneros en el uso clínico de la insulina en aquellos años, entre los que se destaca el Doctor Octavio Montoro. Para realizar este trabajo fue consultada la bibliografía médica de la época, archivos y otras fuentes. Como resultado se obtuvo que en Cuba se introdujo la insulina en el tratamiento de los pacientes diabéticos en febrero de 1923, por el Doctor Montoro, quien fue reconocido por sus conocimientos médicos y por su vasta cultura. Desempeñó múltiples cargos y recibió numerosas condecoraciones. Se concluyó que Cuba fue uno de los primeros países en el mundo que contó con la insulina como arma terapéutica contra la diabetes. El Doctor Octavio Montoro hizo importantes aportes en la investigación sobre la diabetes, por lo que merece ser considerado, a nuestro juicio, como el padre de la diabetología en nuestro país.The clinical use of insulin by Banting and Best represents a hallmark in the history of medical sciences. The advances in this field have been amazing and our country was also involved in this development. However, little is known about the first works carried out by Cuban

  14. La ventana europea: retos de la negociación del Tratado de Libre Comercio de México con la Unión Europea

    OpenAIRE

    Jaime Zabludovsky; Sergio Gómez Lora

    2004-01-01

    Después de más de seis años de gestiones diplomáticas y complejas negociaciones, el primero de julio de 2000 entraron en vigor las disposiciones para liberalizar los flujos de comercio de bienes entre México y la Unión Europea (UE). Estas disposiciones son parte del Tratado de Libre Comercio (TLCUEM) que, a su vez, es uno de los componentes del Acuerdo de Concertación Política, Asociación Económica y Cooperación ("Acuerdo Global").

  15. Maduración sexual en niños con diabetes mellitus tipo 1 tratados con dosis múltiples de insulina Sexual maturation in children presenting with Type 1 diabetes mellitus treated with multiple dose of insulin.

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    Tania Espinosa Reyes

    2007-04-01

    Full Text Available Antes de la terapia insulínica, la menarquia y menstruaciones subsecuentes aparecían raramente en niñas con diabetes mellitus tipo 1 (DM 1 desde la infancia, y en los varones se verificaba un importante retraso puberal. El objetivo del presente trabajo es evaluar el inicio de la pubertad, y la influencia de la edad de diagnóstico de la diabetes y el grado de control metabólico, sobre el desarrollo sexual en un grupo de ninos atendidos en consultas de endocrinología pediátrica. Se realizó un estudio prospectivo no concurrente a partir de las historias clínicas de pacientes tratados con dosis múltiples de insulina, de procedencia urbana (32 varones y 28 hembras, seguidos longitudinalmente por examen clínico y determinaciones bioquímicas periódicas desde el inicio de la DM 1 hasta alcanzar su talla final. El control metabólico fue evaluado a través de la hemoglobina glicosilada (HbA1 realizada trimestralmente, y clasificado según criterios de la institución en bueno (B: 10 %. La media de la edad a la que se encontró un volumen testicular de 4 mL fue 12,5 ± 0,8 años; en las niñas el inicio del desarrollo mamario se constató a la edad promedio de 11,4 ± 1,3 años y la menarquia ocurrió a los 12,9 ± 1,2 años. Se comprobó también que 31 pacientes tuvieron un control metabólico B (51,6 %, 22 R (36,7 % y 7 M (11,7 %. Se concluye que el tratamiento con dosis múltiples de insulina tiene una influencia favorable y decisiva sobre el grado de control metabólico, lo cual hace posible un desarrollo puberal adecuado en pacientes con DM 1.Before insulin therapy, menarche and subsequent menstruation rarely appear in girls presenting Type 1 diabetes mellitus (MD 1 from childhood, and in boys a significicant pubertal retardation was confirmed. Aim of present paper is to assess onset of puberty, influence of diagnosis age of diabetes, and degree of metabolic control, on sexual development in a cohort of children seen in service of

  16. Outcome of sporadic amyotrophic lateral sclerosis treated With non-invasive ventilation and riluzole Sobrevida en pacientes con esclerosis lateral amiotrófica esporádica tratados con ventilación no invasiva y riluzole

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    Martín Sívori

    2007-08-01

    diagnóstico de sALS, según criterios definidos en El Escorial modificados, y fueron seguidos por 60 meses. Veintinueve pacientes recibieron NIV y 68 no (nNIV. En el grupo NIV la sobrevida media fue de 15.41 ± 7.78 meses vs. 10.88 ± 7.78 meses en nNIV (p= 0.028. La sobrevida media de los pacientes que recibieron riluzole (n=44 no fue diferente de la que no lo recibieron (n=53, aunque en el 4° y 5° mes los pacientes tratados con riluzole mostraron un escaso beneficio. Los pacientes que recibieron NIV y riluzole (n=18 tuvieron una sobrevida media de 16.61 ± 10.97 meses vs. 10.69 ± 7.86 meses para los que sólo recibieron tratamiento sintomático (n=42 (p= 0.021. La NIV prolongó significativamente la sobrevida en este grupo de pacientes. El riluzole, empleado como única terapéutica, no lo hizo. Los pacientes que combinaron los dos tratamientos tuvieron la mayor sobrevida.

  17. Composición química, digestibilidad y cinética ruminal de la digestión de residuos agrícolas tratados con explosión de vapor

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    Ricardo Basurto Gutiérrez

    2012-01-01

    Full Text Available Para determinar el efecto de la explosión de vapor (EXPV en la composición y digestibilidad de forrajes toscos (F se condujeron dos experimentos. En el Exp 1, con un diseño factorial de presión (P; 10.3, 13.8 y 17.2 kg cm2 y tiempo (T; 5, 10 y 15 min, se determinaron los cambios en pH, fracciones de fibra (FF y la digestibilidad in vitro (DIVMS del rastrojo de sorgo (RS, rastrojo de maíz (RM y bagazo de caña (BZC por efecto de EXPV. En el Exp 2, se comparó la cinética de la digestión in situ (CDI de forrajes sin tratar y tratados con EXPV, RS y RM fueron tratados con 13.8 kg/cm2 por 10 min y BZC con 17.2 kg/cm2 por 15 min. Se incubaron muestras de forraje en rumen hasta por 120 h. Los datos fueron ajustados a un modelo no lineal. P y T no interactuaron en pH o FF. El aumento en P o T redujeron el pH, FDN y la hemicelulosa. La lignina y FDA no cambiaron dentro los niveles de P o T. En DIVMS, P*F y T*F fueron significativas. EXPV incrementó las fracciones soluble y potencialmente digestible y extensión de digestión de FF de los tres forrajes. Exceptuando para BCZ, el tiempo de retraso no cambió para FF. La respuesta de la tasa de digestión fue variable para FF o forraje. Se concluye que la EXPV mejora la calidad nutritiva de los forrajes toscos por solubilizar parte de la pared celular, acelerar la tasa de digestión e incrementar la extensión de la digestión.

  18. Manifestaciones cardiovasculares en pacientes tratados con hemodiálisis periódica por fístula arteriovenosa funcional

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    Ana S. Ayora Loaiza

    2016-06-01

    Conclusiones: No se encontró relación entre la localización de la fistula y los cambios en el sistema cardiovascular. El grupo de pacientes con fistula de más de cuatro años presentó mayores manifestaciones cardiovasculares y cambios significativos en el ecocardiograma.

  19. CONTROL DE Anastrepha serpentina (Wiedemann Y CALIDAD DE LOS FRUTOS DE ZAPOTE MAMEY Pouteria sapota (Jacq Moore & Stearn TRATADOS CON AIRE CALIENTE FORZADO

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    R. Ariza-Flores

    2009-01-01

    Full Text Available Los objetivos de este estudio fue evaluar la efectividad de tratamientos térmicos con aire caliente forzado húmedo en el combate de la mosca de los zapotes (Anastrepha serpentina Wiedemann "in vivo" y determinar la tolerancia a las condiciones aplicadas de frutos de zapote mamey. Los frutos no fueron dañados internamente por el tratamiento térmico cuando fueron expuestos a 43 °C·120 min-1. Los frutos alcanzaron su madurez de consumo a los ocho días a 25 °C, presentaron cambios rápidamente en color y perdieron más peso; mientras que, a 10 °C se mantuvieron con mayor firmeza, prolongaron su vida de anaquel y mostraron mayores daños en los haces vasculares. Con respecto a la mortandad de los huevos y larvas de mosca de la fruta A. serpentina, éstas fueron del 100 % con la atmósfera controlada (CA de aire caliente a 43 °C·120 min-1, igualmente los frutos no fueron dañados por la aplicación de la CA; las larvas murieron fácilmente por el calor a 40 °C·120 min-1, mientras que los huevos fueron más resistentes ya que ocurrieron larvas emergidas a 25 °C para los ocho días de almacenados.

  20. Evolución clínica de pacientes asmáticos tratados con inmunoterapia. Municipio Majibacoa, 2008-2013

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    Mailin Molina Leyva

    2015-11-01

    Full Text Available Se realizó un estudio cuasi-experimental de corte longitudinal en 50 pacientes asmáticos con edades  entre 5 y 54 años, atendidos en el Servicio de Alergología del municipio Majibacoa de la provincia de Las Tunas; con el objetivo de determinar la evolución clínica con inmunoterapia, en el período de enero 2008 a febrero de 2013. A los pacientes se les administró inmunoterapia específica de ácaros con extractos estandarizados, durante tres años o más de forma subcutánea. El asma bronquial predominó en el sexo femenino y en las edades comprendidas entre 5 y 14 años. Los antecedentes de atopia familiar fueron referidos por el mayor por ciento de los pacientes analizados. Según severidad de la enfermedad, antes del tratamiento prevalecieron los pacientes en la categoría persistente moderada. Se observó mejoría de los síntomas del asma en una elevada proporción de casos.

  1. Ana?lisis cinemático de la marcha en pacientes con pie zambo tratados mediante el me?todo de Ponseti frente a la te?cnica quiru?rgica de liberacio?n posterior

    OpenAIRE

    Ferrando, A.; Salom Taverner, M.; Page, A.

    2018-01-01

    El objetivo principal de este proyecto consiste en valorar la evolución de la marcha en niños en edad preadolescente tratados mediante el método de Ponseti frente a los tratados mediante liberación posterior a partir de técnicas de valoración de la marcha mediante análisis biomecánico. Material y Métodos Estudio retrospectivo de casos y controles aprobado por el comité de ética. Grupo 1: 28 niños (39 pies) tratados mediante liberación posterior. Grupo 2: 18 pacientes (31 pies) tratados median...

  2. Velocidad de la onda de pulso y la excreción urinaria de albumina en pacientes hipertensos tratados con Perindopril

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    J. E. Tobilli

    2002-12-01

    Full Text Available La presión arterial sistólica, la presión arterial diastólica y la excreción urinaria de albúmina (EUA han sido reconocidas como predictores de riesgo cardiovascular. Además, los trastornos de la compliance arterial (CA evaluados mediante la velocidad de la onda de pulso elevada (VOP están estrechamente relacionados con los cambios de la presión arterial y correlacionados con la mortalidad cardiovascular y la presencia de ateroesclerosis. El objetivo primario de este estudio ha sido determinar la relación entre la VOP y la EUA en un grupo de pacientes no fumadores con hipertensión esencial y secundariamente evaluar los cambios producidos por un inhibidor de la enzima convertidora de angiotensina (perindopril sobre estas dos variables. En el estudio participaron setenta pacientes (33 hombres y 37 mujeres hipertensos no fumadores, sin tratamiento previo, de 50 ± 7 años (entre 35-69. La VOP de todos los pacientes fue estudiada por medio de un dispositivo computarizado (Complior en el período basal y a los seis meses de tratamiento con perindopril. También se determinó la EUA por el método de inmunodifusión radial al inicio del tratamiento y luego de seis meses de tratamiento con perindopril (4.6 ± 1.4 mg/día. Al finalizar el estudio se observó una reducción significativa de la presión arterial sistólica (PAS (160.2 ± 10.6 vs. 131.9 ± 7.1 mmHg, p<0.01, presión arterial diastólica (PAD (100.6 ± 5 vs. 81.6 ± 4.8 mmHg, p<0.01, VOP (13.4 ± 1 vs. 9.1 ± 0.9 m/seg, p<0.01 y EUA (42.2 ± 19.3 vs.11.1 ± 3.6 mg/día, p<0.01 al comparar estos valores con los del período basal. Por otra parte, la función renal evaluada por clearance de creatinina mostró una significativa mejoría en relación a los valores iniciales (87.5 ± 22.5 vs. 102.1 ± 23.5 ml/min, p<0.01. Asimismo, se apreció una significativa correlación positiva entre la EUA y la VOP al inicio del estudio (r = 0.81; p<0.01 y después de seis meses de tratamiento

  3. COMPORTAMIENTO DE UN MATERIAL GRANULAR NO TRATADO EN ENSAYOS TRIAXIALES CÍCLICOS CON PRESIÓN DE CONFINAMIENTO CONSTANTE Y VARIABLE BEHAVIOR OF AN UNBOUND GRANULAR MATERIAL IN CYCLIC TRIAXIAL TESTS WITH CONSTANT AND VARIABLE CONFINING PRESSURE

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    Hugo Alexander Rondón Quintana

    2008-12-01

    Full Text Available En un pavimento, cada una de las capas de la estructura experimenta bajo una carga vehicular ciclos de esfuerzo con componentes vertical, horizontal y de corte. Para el estudio de materiales granulares no tratados (utilizados para conformar capas de base y subbase, la mayor parte de las investigaciones se realizan empleando equipos triaxiales cíclicos en donde sólo la carga vertical es cíclica y la presión de confinamiento permanece constante durante el ensayo. Un ensayo que reproduce mejor la forma como se distribuyen los esfuerzos en estas capas es el ensayo triaxial cíclico con presión de confinamiento variable. En este ensayo se pueden modelar las componentes cíclicas tanto en el sentido vertical como horizontal. A pesar que son ensayos distintos, la ingeniería de pavimentos supone que la respuesta que experimentan estos materiales en estos ensayos es similar, lo anterior basado en algunos estudios realizados en la década de los setenta. En la presente investigación se diseña y desarrolla un programa experimental más detallado, para comparar el comportamiento que desarrolla un material granular no tratado en estos ensayos. De los resultados se evidencia que sólo para algunas trayectorias de esfuerzo, la dirección y la acumulación de la deformación vertical y volumétrica es similar.In a pavement structure, passing wheel loads impose cyclic stresses consisting of vertical, horizontal and shear components. Studies of the behavior of unbound granular materials (UGM, used for base and sub-base layers under cyclic loading are mostly performed using the axisymmetric triaxial test with constant confining pressure (CCP test and a cyclic variation of the axial stress. However, in this type of test only the vertical component of the cyclic stress path is considered. The oscillation of the horizontal stress can be reproduced by an additional cyclic variation of the confining pressure (VCP test. CCP and VCP tests are sometimes assumed to

  4. Caracterización de la mezcla de yeso grueso con adición de residuos tratados de placas de yeso laminado

    OpenAIRE

    Rodríguez-Orejón, A.; Del Río-Merino, M.; Fernández-Martínez, F.

    2014-01-01

    La protección del medio ambiente implica la reutilización de los residuos de construcción y demolición. Los residuos de placas de yeso laminado se utilizan en la fabricación de cemento y de placas de yeso laminado. En este artículo se ha estudiado la utilización deresiduos de placa de yeso laminado cocido (YLC) mezclado con yeso grueso (YG), realizándose la caracterización físico-mecánica de dureza superficial y resistencias mecánicas, para determinar su idoneidad formando materiales de ye...

  5. Caracterización por QEMSCAN y FE-SEM de yacimientos de oro tratados artesanalmente con mercurio en Antioquia, Colombia

    OpenAIRE

    Rojas-Reyes, Néstor Ricardo; Echeverry-Vargas, Luver; Cataño-Martínez, Jesús

    2017-01-01

    RESUMEN En este trabajo se presenta la caracterización mineralógica de tres yacimientos auríferos ubicados en el nordeste del departamento de Antioquia, Colombia, que actualmente son beneficiados con mercurio. A tres yacimientos de oro se le realizaron cinco pruebas: determinación de especies minerales y análisis de imágenes en falso color por QEMSCAN(r); identificación y cuantificación de oro por FE-SEM; análisis al fuego y pruebas de cianuración. Los resultados por QEMSCAN mostraron que los...

  6. Perfil eletrocardiográfico e conteúdo glicogênico muscular de ratos tratados com nandrolona Perfil electrocardiográfico y contenido glicogénico muscular de ratones tratados con nandrolona Electrocardiographic profile and muscle glycogen content of rats treated with nandrolone

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    Carlos Alberto da Silva

    2010-12-01

    áfico, contenido glicogénico y de proteínas totales de los músculos cardíacos y esqueléticos, así como las concentraciones plasmática de albúmina. MÉTODOS: Los animales del grupo tratado recibieron la droga en la concentración 5mg/kg por vía subcutánea, dos veces por semana, durante tres semanas. Una vez por semana, los ratones fueron anestesiados con Pentobarbital sódico (50mg/Kg, ip y sometidos a evaluación por medio de electrocardiograma (ECG. Después del período experimental, muestras de los músculos cardíaco (ventrículo izquierdo - VI, sóleo (S, gastrocnemio blanco (GB, gastrocnemio rojo (GV, pectoral (P, intercostal (IC y diafragma (D fueron colectadas y analizadas. Los datos (media±epm fueron evaluados de acuerdo con ANOVA, segundo test de Tukey (p>0,05. RESULTADOS: Los ratones del grupo tratado presentaron alteraciones en los siguientes parámetros cardíacos: intervalo QRS, intervalo QTc y frecuencia cardíaca, caracterizados por un aumento de estos, teniendo el ápice en el intervalo de la semana de pretratamiento a la primera semana. Las reservas de glicógeno en el VI presentaron aumento de 127%. En relación a la cantidad de proteínas totales, una diferencia significativa fue constatada en el S, GV y D. En cuanto al perfil bioquímico y al hematocrito, fue observado un aumento en el porcentaje de eritrocitos. CONCLUSIÓN: El estudio muestra que importantes alteraciones cardíacas son provocadas precozmente, sugiriendo una jerarquía en la secuencia de modificaciones que comprometen la homeostasia del organismo.BACKGROUND: We considered both the indiscriminate use of steroids by top athletes and by physically active individuals. OBJECTIVE: To evaluate the effects of nandrolone decanoate on the electrocardiographic profile, glycogen content and total-protein profile of skeletal and cardiac muscles, as well as the plasma albumin concentrations. METHODS: The drug was administered subcutaneously, at a concentration of 5 mg/kg, twice a week for three

  7. Características clínicas de pacientes tratados con terapia electroconvulsiva en un hospital público de Perú

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    Carla Cortez-Vergara

    2016-01-01

    Full Text Available Con el objetivo de describir el perfil de uso de la terapia electroconvulsiva (TEC en pacientes hospitalizados en el Instituto Nacional de Salud Mental "Honorio Delgado - Hideyo Noguchi" de Lima, Perú, se revisaron las historias clínicas de pacientes que recibieron TEC entre los años 2001 y 2011. Se aplicaron 419 cursos de TEC a 372 pacientes, con un total de 5439 aplicaciones; la esquizofrenia paranoide fue el diagnóstico más frecuente (70,7%, y la indicación más usual fue la resistencia al tratamiento (80,7%; asimismo, la respuesta clínica a la TEC fue buena en 70,1% de casos, mientras que los efectos secundarios, en general, fueron pasajeros y leves. El uso de TEC disminuyó a lo largo del periodo estudiado, pero fue muy tolerable y segura, especialmente en su versión modificada, y mostró una alta respuesta que la mantiene como un tratamiento psiquiátrico de primera línea.

  8. Impacto del síndrome metabólico en la resistencia a la recanalización arterial y en el pronóstico de los pacientes con oclusión aguda de la arteria cerebral media tratados con activador tisular del plasminógeno

    OpenAIRE

    Dorado Bouix, Laura

    2012-01-01

    La recanalización arterial precoz es un punto clave para alcanzar un buen pronóstico funcional tras un ictus isquémico. El síndrome metabólico (SM) podría jugar un papel en la evolución de los pacientes con ictus isquémico tratados con activador tisular del plasminógeno (tPA) por vía sistémica (a) por su asociación a un estado protrombótico que podría interferir en la recanalización arterial inducida por tPA y (b) porque varias de las alteraciones metabólicas que acompañan al SM podrían contr...

  9. Efecto coadyuvante del extracto liofilizado de Passiflora edulis (maracuyá en la reducción de la presión arterial en pacientes tratados con enalapril

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    Juan Rojas

    2009-06-01

    Full Text Available Objetivos: Determinar el efecto coadyuvante antihipertensivo y la seguridad del jugo del fruto de maracuyá en pacientes hipertensos en tratamiento con enalapril. Diseño: Ensayo clínico prospectivo piloto, de fase II, aleatorizado, a doble ciego, de grupos paralelos, controlado, de búsqueda de dosis y evaluación del producto. Institución: Instituto de Investigaciones Clínicas, Facultad de Medicina, UNMSM; Hospital Nacional Dos de Mayo en Lima; Hospital Belén de Trujillo y Centros de Salud de Moche y Laredo, en la ciudad de Trujillo. Participantes: Pacientes hipertensos. Intervenciones: Los pacientes fueron asignados aleatoriamente a 4 grupos. Todos recibieron enalapril 10 mg/día y, además, el primer grupo recibió placebo y los demás 2, 3 y 4 cápsulas de 500 mg de liofilizado de jugo de maracuyá/día, respectivamente. Principales medidas de resultados: Disminución de la presión arterial. Resultados: Los grupos que recibieron enalapril más maracuyá tuvieron una mejor reducción de la presión sanguínea en comparación con el grupo que recibió enalapril más placebo. El grupo tratado con enalapril más 4 cápsulas de jugo liofilizado de maracuyá/día produjo al final del experimento una reducción de la presión sistólica de 6,73 mmHg y de la presión diastólica de 5,33 mmHg (p<0,05, en comparación con el grupo enalapril más placebo. No se observó efectos adversos por el tratamiento. Conclusiones: El jugo del fruto de P. edulis fue coadyuvante efectivo del enalapril en la disminución de la presión arterial en pacientes con hipertensión estadio 1, y demostró ser seguro.

  10. Evaluación clínica y funcional en niños asmáticos tratados con montelukast

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    Concepción Sánchez Infante

    2011-09-01

    Full Text Available Introducción: el asma bronquial es una enfermedad que se considera puede ser controlable, aunque no puede curarse, pero sus manifestaciones clínicas, que son las que afectan al paciente, pueden desaparecer o disminuir hasta lograr una vida normal, o casi normal, para este y sus familiares, con una serie de medidas medicamentosas y no medicamentosas. Objetivo: evaluar la eficacia del montelukast en el tratamiento de niños asmáticos persistentes. Métodos: se realizó un estudio en 65 niños asmáticos persistentes en el Hospital Pediátrico Universitario "William Soler". Se evaluaron los síntomas, pruebas funcionales respiratorias, días perdidos en la escuela, y control de la enfermedad, inicialmente, y un año después de la introducción del montelukast. Se observó la posibilidad de efectos secundarios. Resultados: 55 pacientes (84,6 % tenían tos nocturna diaria antes del tratamiento. Al año, la tos nocturna diaria se observó solo en 9 (13,9 %; 43 (66,1 % presentaban sibilancias al reírse, mientras que al año 1 (1,6 % mantenía sibilancias diarias con la risa; 41 (63,0 % tenían, inicialmente, afectación de la actividad física, mientras que al año 51 (78,4 % no tenían limitaciones. El 100 % tenía ausencias escolares. Durante el año de tratamiento 34 (57,0 % no presentaron días perdidos; 42 (64,6 % tenían crisis diarias, sin embargo, al reevaluar, 38 (58,5 % no tuvieron crisis. Habían tenido ingresos hospitalarios 23 (35,4 %, pero posteriormente solo 5 necesitaron hospitalización. Antes del tratamiento, 49 (75,0 % necesitaron tratamiento de rescate, en cambio, durante el año disminuyó a 27 (41,0 %. 19 niños (38,0 % tenían inicialmente el volumen espiratorio forzado en 1 s menor del 80 %, y solamente 8 (16,0 % posteriormente. Antes del tratamiento el 100 % de los pacientes tenían asma no controlada o parcialmente controlada, mientras que al año el 57 % tenía el asma controlada. No se observaron reacciones adversas

  11. Infecciones asociadas a catéteres en niños tratados con hemodiálisis Catheter-related infections in hemodyalisis-treated children

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    Diana Patricia Durán Casal

    2007-06-01

    Full Text Available Se estudiaron los expedientes clínicos de los 22 pacientes incluidos en el plan de enfermos crónicos del Servicio de Hemodiálisis de nuestro hospital en el 2005. Diez de estos pacientes tenían como acceso vascular temporal para hemodiálisis un catéter venoso central percutáneo (45,5 % y en ellos se registraron 26 procesos infecciosos relacionados con el cateterismo −algunos de ellos presentaron más de un episodio de infección relacionado con el catéter. Los catéteres utilizados fueron colocados por vía percutánea en las venas subclavia, femoral y yugular interna. Los catéteres insertados en la vena femoral presentaron el mayor número de complicaciones infecciosas. El hemocultivo fue positivo para el mismo germen en 14 casos del total de pacientes infectados, lo que evidenció que 53,8 % de los pacientes desarrollaron una infección asociada al uso del catéter. Los gérmenes que predominaron fueron los grampositivos (53,7 %, representados mayoritariamente por el estafilococo coagulasa-negativo. Las sepsis sistémicas predominaron en el estudio y todos los pacientes desarrollaron manifestaciones clínicas. En nuestro servicio la tasa estimada de sepsis por catéter para hemodiálisis fue de 18,1 %.The medical histories of the 22 patients from the chronically-ill patient program of Hemodyalisis Service at our hospital were studied in 2005. Ten of them had a central percutaneous venous catheter as a temporary vascular access for hemodyalisis (45,5%, but they also suffered 26 catheter-related infectious processes, some of them even more than one episode of infection. The used catheters were percutaneously placed in subclavian, femoral and internal jugular veins. Those catheters inserted into the femoral vein exhibited the highest number of infectious complications. Hemoculture was positive to the same germ in 14 cases of the total number of infected patients, which proved that 53,8% of patients developed catheter-related infection

  12. Valor predictor del cociente saturación hemoglobina/fio2 en pacientes pediátricos con insuficiencia respiratoria aguda debida a neumonía tratados con ventilación no invasiva. Predictive value of the pulse oximetric saturation/fraction of inspired oxygen ratio in pediatric patients with acute respiratory failure due to pneumonia treated with non-invasive ventilation

    OpenAIRE

    Palanca Arias, Daniel

    2014-01-01

    RESUMEN: El uso de la ventilación no invasiva (VNI) en pacientes con fracaso respiratorio hipoxémico debido a neumonía es controvertido, alcanzando elevadas tasas de fracaso en el Síndrome de Distrés Respiratorio Agudo (SDRA). Recientemente, el cociente SpO2/FiO2 (SF) se ha equiparado al cociente paO2/FiO2 (PF) para la valoración del SDRA. Determinamos en una cohorte de pacientes, diagnosticados de neumonía y tratados con VNI, si el cociente SF es una variable con valor predictor de fraca...

  13. Leishmaniosis laríngea recidivante: un caso inusual en un paciente inmunocompetente tratado con corticoides Recidivant laryngeal leishmaniosis: an unusual case in an immunocompetent patient treated with corticosteroids

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    R. Casero

    2010-06-01

    Full Text Available La leishmaniosis es una parasitosis de evolución crónica; en Argentina, sus agentes etiológicos principales pertenecen al complejo Leishmania (Viannia braziliensis, habitualmente asociado a lesiones cutáneas y mucocutáneas. Informamos en este trabajo un caso de leishmaniosis laríngea en un hombre de 29 años procedente de Jujuy, quien a raíz de múltiples subdiagnósticos portaba esta parasitosis desde hacía 20 años. En el año 2008 este paciente consulta por disfonía crónica y trastornos en las vías aéreas superiores, refiere que fue sometido a terapias con tuberculostáticos, antifúngicos y corticoides desde 2002. Diferentes biopsias y fibroscopías revelaron los siguientes diagnósticos: laringitis granulomatosa inespecífica, laringitis compatible con tuberculosis, laringitis compatible con histoplasmosis, linfoma Natural Killer extraganglionar a células pequeñas. Finalmente, estudios realizados en nuestro hospital demostraron la presencia de una laringe granulomatosa en toda su extensión, amastigotes intra y extracelulares de Leishmania spp., ausencia de formas compatibles con Micobacterias e Histoplasma, y laringitis crónica vinculable a Leishmania spp. El paciente realizó tratamiento con antimoniato de N-metil-glucamina y demostró una muy buena evolución clínica tras ser examinado 2 meses después. Si bien la leishmaniosis laríngea como lesión única no es la presentación prevalente de esta zoonosis, su estudio amerita especial atención en pacientes tratados con corticoides, pues esto evitará un diagnóstico tardío y las mayores consecuencias asociadas a la morbimortalidad propia de esta parasitosis.Leishmaniosis is a chronic parasitic disease, which in Argentina is mainly caused by protozoa belonging to the Leishmania (Viannia braziliensis complex, leading to cutaneous and mucosal pathologies. We report a rare case of laryngeal leishmaniosis in a 29 year-old man from Jujuy province, Argentina, who had been

  14. Ivermectin-related adverse clinical events in patients treated for Mansonella ozzardi infections Efectos clínicos adversos relacionados con ivermectina en pacientes tratados por infecciones con Mansonella ozzarddi

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    Alejandro J. Krolewiecki

    2011-03-01

    Full Text Available We report the occurrence of serious reactions after treatment with oral ivermectin in two patients with Mansonella ozzardi infections. Both had systemic and respiratory symptoms and recovered without sequelae. Follow-up revealed clearance of microfilaremia in both cases, with relapse in one of them. These reactions are well described in the treatment of other filarial infections, but have not yet been reported in the treatment of M. ozzardi. We are now reporting the first such known reactions with this helminthiasis.Se informa la aparición de reacciones adversas graves con el tratamiento con ivermectina oral en dos pacientes con infección por Mansonella ozzardi. Ambos presentaron síntomas respiratorios y sistémicos y se recuperaron sin secuelas. El seguimiento mostró ausencia de microfilaremia en ambos casos, con recidiva en uno de ellos. Estas reacciones, bien conocidas durante el tratamiento de otras filariosis, se describen por primera vez con esta helmintiasis.

  15. Calidad de vida en pacientes con isquemia crónica de miembros inferiores tratados con células madre adultas Quality of life in patients with chronic lower limb ischemia treated with adult stem cells

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    Amel Alfonso-Simón

    2012-12-01

    Full Text Available Se hizo una evaluación de la calidad de vida en 45 pacientes mayores de 60 años con isquemia arterial crónica de miembros inferiores; de ellos, 34 con isquemia severa y 11 con pie diabético isquémico, también con lesiones severas. A todos se les habían implantado en el miembro inferior afectado, células mononucleares derivadas de la médula ósea movilizadas a la sangre periférica con factor estimulador de colonias de granulocitos. Para la evaluación de la calidad de vida se seleccionó el cuestionario SF-36, que centra su contenido en 2 áreas: el estado funcional y el bienestar emocional. En todos los casos se manifestó una mala calidad de vida preimplante. La mejoría fue evidente a partir del sexto mes después de la terapia celular. Los casos con un año de evolución habían logrado una buena calidad de vida. La mayor parte de los pacientes que evolucionaron satisfactoriamente pudieron incorporarse a las actividades sociales y laborales, lo que con anterioridad no les era posible.An assessment of the quality of life in 45 patients older than 60 years with chronic arterial ischemia of the lower limbs was conducted. Out of them, 34 had severe ischemia, and 11 had ischemic diabetic foot, as well as severe injuries. All had been implanted mononuclear cells in the affected lower limb, which derived from the bone marrow, and mobilized to the peripheral blood with granulocyte colony stimulating factor. For assessing quality of life, SF-36 questionnaire was selected, which focuses its content on two areas: functional status and emotional well being. All cases showed poor quality of life before implantation. Improvement was evident on the sixth month after cell therapy. Cases with a year of evolution had achieved good quality of life. Most of the patients, who had successful outcomes, could join social activities and employment, which was previously not possible.

  16. Overexposure of radiation therapy patients in Panama: problem recognition and follow-up measures La sobreexposición de pacientes tratados con radioterapia en Panamá: reconocimiento del problema y medidas de seguimiento

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    Cari Borrás

    2006-09-01

    se encontraban físicos médicos de la Organización Panamericana de la Salud (OPS, quienes comprobaron que 56 pacientes con cáncer cérvico-uterino, de endometrio, de próstata o de recto tratados mediante campos de teleterapia parcialmente bloqueados recibieron dosis calculadas mediante un sistema computarizado de planificación de tratamientos. Los físicos médicos de la OPS comprobaron que solo 11 de esos 56 pacientes recibieron una dosis absorbida dentro de los límites aceptables de ±5%. Veintiocho de los 56 pacientes recibieron dosis con errores entre +10 y +105%. De esos 28 pacientes que fueron sobreexpuestos, según los físicos del ION, 23 murieron antes de septiembre de 2005; de ellos, 18 murieron a causa de los efectos de las radiaciones, principalmente complicaciones rectales. Las consecuencias clínicas, psicológicas y jurídicas de esta sobreexposición menoscabaron gravemente los tratamientos contra el cáncer en Panamá y llevaron a la OPS a examinar de cerca las prácticas de radioterapia oncológica en América Latina y el Caribe. Los médicos del ION evaluaron los resultados del tratamiento de 125 pacientes atendidos en ese mismo intervalo de tiempo por los mismos tipos de cáncer sin haber sufrido sobreexposición y encontraron una tasa de recurrencia de cáncer cervicouterino mayor de la esperada. Esto llevó a la OPS a lanzar una iniciativa para la acreditación de los centros de radioterapia oncológica en América Latina y el Caribe, en colaboración con las sociedades profesionales de radioncólogos, físicos médicos y tecnólogos de radioterapia. La Asociación Latinoamericana de Terapia Radiante Oncológica estableció una comisión de acreditación que exigirá que los centros establezcan programas integrales de garantía de la calidad en radioterapia oncológica según los lineamientos internacionales. Asimismo, se recogerán datos estadísticos acerca de los resultados observados en los pacientes tratados para documentar las

  17. Síndrome de lisis tumoral en un paciente con cáncer de riñón tratado con sunitinib Tumor lysis syndrome in a patient with a renal carcinoma treated with sunitinib

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    Ezequiel Rodríguez-Reimúndes

    2011-04-01

    Full Text Available El síndrome de lisis tumoral (SLT es un trastorno metabólico que ocurre como consecuencia de una destrucción celular masiva. Se caracteriza por la presencia de hiperuricemia, hiperfosfatemia, hipocalcemia e hiperkalemia, y predispone al desarrollo de insuficiencia renal aguda. En la mayoría de los casos el SLT ocurre luego de instaurarse un tratamiento antitumoral y es más frecuente en tumores de alto grado de malignidad y alta sensibilidad a la quimioterapia. Presentamos el caso de un paciente con diagnóstico de cáncer de riñón recidivado que presenta un SLT e insuficiencia renal aguda luego de iniciar tratamiento con sunitinib.The tumor mor lysis syndrome (TLS is a metabolic disorder resulting from a massive tumor breakdown. It is characterized by hyperuricemia, hyperphosphatemia, hypocalcemia and hyperkalemia and predisposes to acute renal failure. TLS usually occurs after the initiation of cytotoxic therapy and is more frequent in the case of neoplasias with a high proliferative rate or that are highly chemo-sensitive. We report the case of a man with a recurrent kidney cancer who presented with a TLS and acute renal failure after initiation of sunitinib.

  18. Resultados del seguimiento de pacientes con Trastorno Obsesivo Compulsivo tratados con dos variantes de Terapia Cognitiva Follow-Up of patients with Obsessive Compulsive Disorder treated with two variants of Cognitive Therapy

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    Ricardo Rodríguez Biglieri

    2007-12-01

    Full Text Available El artículo presenta los resultados del seguimiento a 6 meses realizado a pacientes con trastorno obsesivo compulsivo en el marco del proyecto UBACyT P079. Para el estudio se utilizó un diseño de caso único (A-B con replicación directa entre sujetos. Ocho pacientes fueron asignados aleatoriamente a una de las dos condiciones de tratamiento ofrecidas: 1 Terapia centrada en exposición y Prevención de respuesta; 2 Terapia Metacognitiva. Dos de los pacientes en la primera condición abandonaron el tratamiento tras la tercera sesión. Los cuatro de la segunda condición finalizaron el protocolo establecido. Los resultados para ambos tipos de terapia muestran una mejoría significativa en la sintomatología obsesiva y depresiva tras su aplicación, resultados que se han mantenido estables en las evaluaciones de seguimiento, sugiriendo la utilidad clínica de ambas terapias. Se discuten las implicaciones teóricas y prácticas de los resultados y se sugieren nuevas líneas de investigación.The article presents the follow-up at six months of patients with obsessive compulsive disorder treated in the context of UBACyT project P079. A single case design (A-B between subjects with direct replication was used. Eight patients were randomly assigned to one of two different treatment conditions: 1 Exposure and Response Prevention Therapy (Ex/PR; 2 Metacognitive Therapy (MT. Two patients in the Ex/PR condition dropped out after the third session. There was no dropout of patients under MT condition. Outcomes from both kinds of treatment show a significant improvement in obsessive and depressive sympthomatology after the interventions. These findings were sustained at the follow- up evaluations, suggesting that both treatments may be of clinical utility. Theoretical and practical implications are discussed, and further lines of investigation are outlined.

  19. The Structure and Content of Agreements between the Agency and States required in connection with the Treaty on the Non-Proliferation of Nuclear Weapons; Estructura y contenido de los acuerdos entre los Estados y el Organismo requeridos en relacion con el Tratado sobre la no proliferacion de las armas nucleares

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1971-05-15

    The Board of Governors has requested the Director General to use the material reproduced in this booklet as the basis for negotiating safeguards agreements between the Agency and non-nuclear-weapon States party to the Treaty on the Non-Proliferation of Nuclear Weapons [Spanish] El Acuerdo debe contener, de conformidad con el parrafo 1 del Articulo III del Tratado sobre la no proliferacion de las armas nucleares, el compromiso de aceptar salvaguardias por parte del Estado de conformidad con los terminos del Acuerdo, sobre todos los materiales basicos o materiales fisionables especiales en todas las actividades nucleares con fines pacificos realizadas en su territorio, bajo su jurisdiccion, o efectuadas bajo su control en cualquier lugar, a efectos unicamente de verificar que dichos materiales no se desvian hacia armas nucleares u otros dispositivos nucleares explosivos.

  20. La Salud y el Tratado de Libre Comercio (TLC.

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    Gustavo Malagón Londoño

    2004-09-01

    Se pregunta uno si con el espectro proyectado las pretensiones de obligar a normas rígidas de patentes, propiedad intelectual y otras inherentes se lograría un tratado justo o mas bien se agravaría la situación de los países en serios problemas actualmente...

  1. The Text of the Agreement between Iran and the Agency for the Application of Safeguards in connection with the Treaty on the Non-Proliferation of Nuclear Weapons; Texto Del Acuerdo Concertado Entre El Iran Y El Organismo Para La Aplicacion De Salvaguardias En Relacion Con El Tratado Sobre La No Proliferacion De Las Armas Nucleares

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1974-12-17

    The text of the agreement between Iran and the Agency for the application of safeguards in connection with the Treaty on the Non-Proliferation of Nuclear Weapons is reproduced in this document for the information of all Members [Spanish] Para informacion de todos los Estados Miembros, en el presente documento se trans cribe el texto del Acuerdo concertado entre el Iran y el Organismo para la aplicacion de salvaguardias en relacion con el Tratado sobre la no proliferacion de las armas nucle ares.

  2. Determinação das substâncias reativas ao ácido tiobarbitúrico como indicador da peroxidação lipídica em ratos tratados com sevoflurano Determinación de las substancias reativas al ácido tiobarbitúrico como indicador de la peroxidación lipídica en ratones tratados con sevoflurano Thiobarbituric acid reactive substances as an index of lipid peroxidation in sevoflurane-treated rats

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    Francisco José Lucena Bezerra

    2004-10-01

    biotransformación dos éteres sobre la acción del citocromo P450, uno de los posibles mecanismos de toxicidad hepática y renal promovida por eses compuestos. El objetivo de este estudio fue determinar los niveles de substancias reactivas al ácido tiobarbitúrico (SRAT, como indicador de la peroxidación lipídica, en ratones que recibieron sevoflurano, previamente tratados o no con isoniazida, inductora enzimática del citocromo P450 2E1. MÉTODO: Los animales fueron distribuidos aleatoriamente en 4 grupos que recibieron respectivamente: G1 - oxígeno a 100% 1 l.min-1/60 minutos por 5 días consecutivos; G2 - sevoflurano a 4% en oxígeno a 100%, 1 l.min-1/60 minutos por 5 días consecutivos; G3 - isoniazida (50 mg.kg-1.dia por vía intraperitoneal durante 4 días consecutivos, en seguida fue tratado como el G1, en G4 - isoniazida 50 mg.kg-1.dia por vía intraperitoneal durante 4 días consecutivos, siendo tratado, posteriormente, como el G2. Después de 12 horas del último tratamiento, se sacrificaran los animales y fue colectado el plasma para la análisis de las SRAT, siendo removido el lóbulo izquierdo del hígado y de los riñones para examen histológico. RESULTADOS: Los resultados mostraron aumento en las tasas de SRAT en el G3 y G4, con elevación discreta en G2. El estudio histológico reveló necrosis focal en el hígado de ratones pre-tratados con isoniazida (G3. CONCLUSIONES: El sevoflurano promovió peroxidación lipídica apenas cuando asociado a la isoniazida.BACKGROUND AND OBJECTIVES: Sevoflurane is a fluorinated ether with low blood solubility and biotransformed by an oxidative enzymatic liver system involving cytochrome P450 2E1. Lipid peroxidation occurs during ethers biotransformation process under action of cytochrome P450, a possible mechanism for liver and kidney toxicity promoted by such compounds. This study aimed at determining the levels of substances reactive to thiobarbituric acid (TBARS, as an index for lipid peroxidation in sevoflurane

  3. Análisis jurídico en relación con la aplicación provisional de tratados en Colombia. Una perspectiva de derecho internacional y nacional

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    Juan Camilo Rojas-Arias

    2015-01-01

    Full Text Available Este trabajo discute, desde una perspectiva del derecho internacional y del derecho constitucional, la prerrogativa del Gobierno de Colombia de aplicar provisionalmente un tratado en cumplimiento de las disposiciones legales sobre la materia. Este análisis teórico y práctico, busca examinar los criterios de aplicación de la precitada figura a fin de presentar algunas conclusiones al respecto.

  4. La ruptura de las relaciones diplomáticas: Una aproximación sistemática con una referencia especial a las consecuencias de la entrada en vigor del tratado de Lisboa en la praxis diplomática

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    Carles Pérez-Desoy i Fages

    2013-12-01

    Full Text Available Este trabajo tiene por objeto ofrecer un análisis sistemático de las distintas formas en que puede producirse la ruptura de relaciones diplomáticas entre dos estados soberanos, así como de las diversas fases en que puede descomponerse un proceso de este tipo, caracterizadas por la adopción de distintos tipos de medidas diplomáticas y la combinación de unas con otras (llamada a consultas, retirada de Embajadores, etc. lo que constituye un lenguaje de signos decodificable en términos diplomáticos, que ha sido poco estudiado desde un punto de vista sistemático. El elemento casuístico es, necesariamente, muy importante, máxime cuando las referencias a esta cuestión dentro de las normas codificadas del Derecho Diplomático son muy limitadas, y la jurisprudencia es con frecuencia inexistente. Por otra parte, la entrada en vigor del Tratado de Lisboa, y la puesta en marcha del Servicio de Acción Exterior Europeo (SEAE abre la posibilidad de que, en caso de crisis diplomática, acciones características de la diplomacia clásica puedan ser aplicadas también en el marco del proceso de toma de decisiones colectivas de la UE, ampliando así significativamente la panoplia de posibles medidas a adoptar. La entrada en vigor del Tratado de Lisboa abre también nuevas opciones teóricas de gran interés en el caso de ruptura de relaciones diplomáticas de un Estado Miembro de la UE con un tercer Estado, como por ejemplo la posible creación de una "sección de intereses" de ese Estado en el seno de la Delegación de la UE en ese país

  5. El leasing financiero internacional en el tratado UNIDROIT

    OpenAIRE

    Flores Doña, Mª Sierra

    1998-01-01

    El Tratado UNIDROIT se refiere al contrato de leasing financiero internacional, esto es, al celebrado entre una Sociedad de leasing y un empresario con establecimientos (principal o secundario) situados en el territorio de dos Estados contratantes y caracterizado porque la primera adquiere elementos integrantes del patrimonio empresarial a un fabricante, según las instrucciones recibidas por su cliente y a quien se le entregará para su uso a cambio del pago de cuotas períodicas, al margen de ...

  6. Oportunidades comerciales para productores y exportadores colombianos de mangostanes y mangos en los Países Bajos a partir del Tratado de Libre Comercio con la Unión Europea

    OpenAIRE

    Pardo Ibáñez, Sara Valentina; Picón Villamil, Yussi Andrea; Sassón Beltrán, Melissa

    2016-01-01

    El presente trabajo de investigación se realizó con el propósito de esclarecer y brindarle información pertinente y actualizada a los productores nacionales de frutas exóticas como el mango y el mangostán, acerca de las oportunidades comerciales que estos poseen con países pertenecientes a la Unión Europea (UE), debido al creciente consumo de frutas en estos países y al acuerdo comercial vigente que posee Colombia y la UE. Con el fin de que el sector agrícola crezca y pueda establecerse en me...

  7. El Tratado de Lisboa (Un juego de espejos rotos

    Directory of Open Access Journals (Sweden)

    Juan Manuel de Faramiñán Gilbert

    2009-01-01

    Full Text Available El fracaso del Tratado por el que se establece una Constitución para Europa produjo un periodo de incertidumbre y perplejidad del que ha costado mucho sobreponerse. Por un momento, todo parecía resquebrajarse y se tuvo la sensación de que la imagen de unidad en la diversidad, que con tanta dificultad se había forjado, se partía hecha añicoscomo un espejo roto. No obstante, como en un “juego de espejos rotos”, el ideal europeísta se ha ido recomponiendo con un gran esfuerzo, dando lugar a un texto, el Tratado de Lisboa, que encierra una solución de compromiso con el fin de saldar la crisis cuando el futuro de la Unión Europea parecía oscurecerse. Como en los poemas de Alejandra Pizarnik, “cuando el palacio de la noche encierra su hermosura, pulsaremos los espejos hasta que nuestros rostros canten como ídolos” y, así fue como con un esfuerzo milimetrado se ha ido recomponiendo este rompecabezas de cristales con el fin de que en él se refleje, otra vez, la ansiada imagen global. Como se señala enPreámbulo del Tratado de Lisboa, deberemos estar resueltos a salvar una nueva etapa en proceso de integración europea y habrá que recordar “la importancia histórica de que la división del continente europeo haya tocado a su fin y la necesidad de sentar unas bases firmes para la construcción de la futura Europa”.

  8. ACERO GALVANIZADO PRE-TRATADO CON PELÍCULAS HÍBRIDAS OBTENIDO POR RECUBRIMIENTO POR INMERSIÓN: INFLUENCIA DE LA VELOCIDAD DE RETIRADA DEL SUBSTRATO DEL SOL

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    Sandra Kunst

    2013-01-01

    Full Text Available En el presente trabajo, el acero galvanizado fue revestido con una película de silano obtenido a partir de un sol constituido por los precursores silano 3-(trimetoxisililpropil metacrilato (Tmspma y Tetraetoxisilano (Teos con adición de nitrato de cerio [0,01 M]. Se emplearon diferentes velocidades de retirada del sol (10, 20 y 30 cm.min-1, la caracterización de las películas fue realizada por Microscopía Electrónica de Barrido (MEB, perfilometría, ángulo de mojabilidad, potencial de circuito abierto, espectroscopia de impedancia electroquímica y polarización potenciodinámica. Los resultados muestran que la velocidad de retirada influye en el comportamiento electroquímico de las películas, las películas con mejor resistencia a la corrosión se obtiene con menores velocidades de retirada (10 y 20 cm.min-1.

  9. El sector agropecuario mexicano: un decenio con el Tratado de Libre Comercio de Norteamérica. La pobreza y la desigualdad se intensifican, crece la migración

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    Alicia Puyana

    2005-11-01

    Full Text Available México es una de las economías de tamaño intermedio más abiertas del orbe. Los aranceles se han abatido y el flujo de bienes, servicios y capitales, es prácticamente libre. Ha conformado zonas de libre comercio con casi todos los países desarrollados y con un amplio número de naciones en vía de desarrollo. Guardar coherencia con el TLCAN se ha convertido en el mapa de ruta que guía toda la estrategia comercial, de tal forma que el TLCAN innovó en muchos sentidos. Integró asimetrías inéditas e incorporó los acuerdos sobre propiedad intelectual, intercambio de servicios y los compromisos sobre inversión extranjera, que sólo se incluían en mercados comunes o en uniones económicas, además, sometió el sector agropecuario al proceso de desgravación arancelaria, cuando los esquemas de integración económica buscaban ganancias en productividad para el sector industrial. La importancia de estudiar los efectos del TLCAN sobre la agricultura mexicana se derivan de numerosos aspectos: la menor productividad de ésta, el peso de la economía campesina y la intensidad de la pobreza rural en la economía nacional.

  10. Optimización y análisis del comportamiento de materiales tratados con cal en carreteras : aplicación a lodos de tuneladora y mezclas bituminosas

    OpenAIRE

    Movilla Quesada, Diana

    2012-01-01

    En esta tesis doctoral se presentan diversos estudios experimentales mediante los cuales se mejoran materiales utilizados en carreteras, tanto en terraplenes como firmes, añadiendo diferentes filleres. Esta tesis está constituida por una compilación de artículos centrados en una misma línea de investigación: Tratamiento de materiales con cal, como material de aportación. Este tratamiento abarca diversos tipos de materiales, desde lodos procedentes de tuneladora que no han sido dispuestos e...

  11. La Alianza Bolivariana para las Américas-Tratado de Comercio de los Pueblos (ALBA-TCP: análisis de un proyecto de integración regional latinoamericana con una fuerte dimensión altermundialista.

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    Francisco Javier Ullán de la Rosa

    2011-11-01

    Full Text Available El ALBA-TCP es una de las organizaciones internacionales de más reciente creación. Es, sin duda, un proyecto original, diferente a las fórmulas de integración regional conocidas y preexistentes: fuertemente dirigido desde lo político, se propone como un mecanismo para planificar desde lo público las relaciones económicas y comerciales entre países, evitando o reduciendo en lo posible la competencia de mercado y fomentando la cooperación y las sinergias desde valores socialistas y de solidaridad. Y todo esto como expresión de una encrucijada ideológica donde crecen y se mezclan, con la lógica del collage posmoderno, casi todas las corrientes del pensamiento social de izquierda. El ALBA y los gobiernos que lo integran se encuentran en medio de una confrontación geopolítica e ideológica de escala continental que sesga enormemente la objetividad de los análisis. Este artículo pretende superar dichos sesgos presentando un análisis académico riguroso y sin toma de partido alguno. En él se analizan las circunstancias históricas que envuelven el nacimiento y evolución del ALBA y se incursiona en el análisis de su programa ideológico y sus proyectos concretos, señalando su convergencia con los del movimiento altermundialista latinoamericano y mundial. Por último, se apuntan algunas estadísticas de desarrollo concretas a fin de valorar los resultados en la práctica de las políticas económicas de este bloque regional.

  12. Modificaciones en la estructura celular por microscopia confocal en pacientes con queratocono tratados por crosslinking Changes in the cell structure of patients with keratoconus under cross-linking treatment by using confocal microscopy

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    Madelyn Jareño Ochoa

    2012-12-01

    Full Text Available Objetivo: describir las modificaciones en la estructura celular corneal después del tratamiento con crosslinking en pacientes con queratocono. Métodos: la muestra estuvo conformada por 30 pacientes (30 ojos con queratocono progresivo a los que se les realizó crosslinking del colágeno corneal y microscopia confocal. Se analizaron como variables las alteraciones en los plexos nerviosos sub-basal y subepitelial, en los nervios estromales, las modificaciones de los queratocitos en estroma anterior y medio, los cambios de las células endoteliales, la profundidad del tratamiento, así como la presencia y evolución del haze y el edema estromal. Resultados: los plexos nerviosos sub-basal y subepitelial estuvieron ausentes durante el primer mes, hubo una recuperación parcial a los 6 meses (73,3 % y total al año. Las fibras nerviosas estromales estuvieron ausentes al mes, a los 6 meses se recuperaron en 96,7 % y de manera total al año. Se encontró alteración de la morfología de los queratocitos del estroma anterior y medio en el primer mes (96,7 %, con inicio de la repoblación celular en 83,3 % a los 3 meses y al año se evidenció una regeneración total. El edema estromal estuvo presente en el primer mes en 83,3 % de los casos, solo en 3,3 % a los 6 meses y al año no hubo ningún paciente. El haze se observó al mes y a los tres meses en el 100 % de los pacientes, predominó al mes en el grado II, a los seis meses con grado I y disminuyó a 60 % sin haze al año. No se encontraron alteraciones en la morfología o densidad de las células endoteliales. Conclusiones: los resultados obtenidos reafirman los criterios de que el crosslinking del colágeno corneal es un método de tratamiento seguro.Objective: to describe the changes of the corneal cellular structure of patients with keratoconus after the cross-linking treatment. Methods: the sample was made up of 30 eyes from 30 patients, who had progressive keratoconus and were treated with

  13. Estimación de la conductividad hidráulica saturada in situ en un suelo tratado con vinaza Field satured hydraulic conductivity estimation on vinasse trated soil

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    Ludwig M Rojas D

    2008-06-01

    Full Text Available Se estimaron los cambios en la conductividad hidráulica saturada mediante las técnicas de caída de carga" y "fuente localizada de agua en un suelo Ustipsamment típico arenoso isohipertérmico con dosis diluidas de vinazas. La investigación se realizó en el centro experimental de la Universidad Nacional de Colombia Sede Palmira (3° 25'39.81" N y 76° 25'45.70" o, 953 m.s.n.m, 24 °C y 60% HR, 1.020 mm. Los dos métodos no difirieron de forma significativa (pChanges of the satured hydraulic conductivity in a soil was estimated using the “falling head” and “point source” methods. The soil treated with vinasse was an Ustipsamment Typic Sandy Isohipertermic located at the experimental center of the National University of Colombia at Palmira (3° 25' 39.81" N, 76° 25' 45.70" W; 953 m.a.s.l., 24 °C, 60% RH. and 1020 mm.. The field methods used did not show statistical differences for the estimation of the satured hydraulic conductivity (p<0.05. However, a decreasing exponential relationship between hydraulic conductivity and vinasse concentration was found. The hydraulic conductivity was reduced about of 50% from the initial value to 2° Brix in a sandy soil, 5.3° brix to a sandy loam soil and 6.1° Brix to a clay loam soil.

  14. Evaluación clínica y funcional en niños asmáticos tratados con montelukast Clinical and functional evaluation in asthmatic children treated with montelukast

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    Concepción Sánchez Infante

    2011-09-01

    Full Text Available Introducción: el asma bronquial es una enfermedad que se considera puede ser controlable, aunque no puede curarse, pero sus manifestaciones clínicas, que son las que afectan al paciente, pueden desaparecer o disminuir hasta lograr una vida normal, o casi normal, para este y sus familiares, con una serie de medidas medicamentosas y no medicamentosas. Objetivo: evaluar la eficacia del montelukast en el tratamiento de niños asmáticos persistentes. Métodos: se realizó un estudio en 65 niños asmáticos persistentes en el Hospital Pediátrico Universitario "William Soler". Se evaluaron los síntomas, pruebas funcionales respiratorias, días perdidos en la escuela, y control de la enfermedad, inicialmente, y un año después de la introducción del montelukast. Se observó la posibilidad de efectos secundarios. Resultados: 55 pacientes (84,6 % tenían tos nocturna diaria antes del tratamiento. Al año, la tos nocturna diaria se observó solo en 9 (13,9 %; 43 (66,1 % presentaban sibilancias al reírse, mientras que al año 1 (1,6 % mantenía sibilancias diarias con la risa; 41 (63,0 % tenían, inicialmente, afectación de la actividad física, mientras que al año 51 (78,4 % no tenían limitaciones. El 100 % tenía ausencias escolares. Durante el año de tratamiento 34 (57,0 % no presentaron días perdidos; 42 (64,6 % tenían crisis diarias, sin embargo, al reevaluar, 38 (58,5 % no tuvieron crisis. Habían tenido ingresos hospitalarios 23 (35,4 %, pero posteriormente solo 5 necesitaron hospitalización. Antes del tratamiento, 49 (75,0 % necesitaron tratamiento de rescate, en cambio, durante el año disminuyó a 27 (41,0 %. 19 niños (38,0 % tenían inicialmente el volumen espiratorio forzado en 1 s menor del 80 %, y solamente 8 (16,0 % posteriormente. Antes del tratamiento el 100 % de los pacientes tenían asma no controlada o parcialmente controlada, mientras que al año el 57 % tenía el asma controlada. No se observaron reacciones adversas

  15. Metástasis cervical contralateral en el carcinoma epidermoide de la cavidad oral: Estudio clínico analítico retrospectivo en 315 pacientes primariamente tratados con cirugía Contralateral neck metastasis in squamous cell carcinoma of the oral cavity: An analytical retrospective clinical study of 315 patients primarily treated with surgery

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    R. González-García

    2008-06-01

    Full Text Available Objetivos. Existen en la literatura numerosos estudios en relación con los factores pronósticos implicados en la aparición de metástasis cervicales ipsilaterales en el carcinoma epidermoide de cavidad oral. Sin embargo, no existen estudios clínicos amplios acerca de la asociación de factores clínico-patológicos y la aparición de metástasis cervicales contralaterales tras la resección quirúrgica del tumor primario. El propósito de este estudio es el análisis de los factores implicados en la aparición de metástasis cervical contralateral en pacientes con carcinoma epidermoide de cavidad oral primariamente tratados con cirugía. Pacientes y métodos. Se analizó una serie de 315 pacientes consecutivos con carcinoma epidermoide de la cavidad oral no tratados previamente. Se realizó un estudio complementario del subgrupo de 203 pacientes con carcinoma epidermoide del borde lateral de la lengua libre, por tratarse de un grupo muy prevalente en la serie analizada. Todos los pacientes recibieron tratamiento quirúrgico con o sin tratamiento radioterápico adyuvante. Varias fueron las variables clínicas e histopatológicas analizadas, como son: las características clínicas del tumor, el estadio tumoral, el grado de diferenciación histológica, el tipo de disección cervical, la supervivencia enfermedad- específica, los márgenes quirúrgicos en la pieza resecada, la extensión ganglionar extracapsular, la diseminación perineural y la afectación ósea. Resultados. La duración media del seguimiento de los pacientes que sobrevivieron fue de 70,9 ± 49,6 meses. Ochenta y tres pacientes murieron a causa de la enfermedad a lo largo del seguimiento. Cuarenta y siete de estos pertenecían al subgrupo de pacientes con carcinoma epidermoide de lengua. Un total de 147 pacientes permanecía vivo sin evidencias de recurrencia de la enfermedad al final del periodo de seguimiento, 116 de los cuales correspondían al subgrupo de pacientes con

  16. Field satured hydraulic conductivity estimation on vinasse trated soil Estimación de la conductividad hidráulica saturada in situ en un suelo tratado con vinaza

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    Menjívar Flórez Juan Carlos

    2008-06-01

    Full Text Available Changes for soil satured hydraulic conductivity were estimated by using the “falling head” and “point source” methods. The soil type trated with vinasse was Ustipsamment Typic Sandy Isohipertermic located at Colombia National University experimental center (3° 25' 39.81"; N, 76° 25' 45.70"; W; 953 m.s.n.m., 24 °C, 60% HR. and 1020 mm.. The used field methods did not show statistical differences for the estimation of the satured hydraulic conductivity (p<0.05, however a decreasing exponential relationship between hydraulic conductivity and vinasse concentration was found. The hydraulic conductivity was reduced about of 50% from the initial value to 2° brix in sandy soil, 5.3° brix to sandy loam soil and 6.1° brix to clay loam.Key words: Point source method; Simulation models; Falling head method; Irrigation.Se estimaron los cambios en la conductividad hidráulica saturada mediante las técnicas de “caída de carga” y “fuente localizada de agua” en un suelo Ustipsamment típico arenoso isohipertérmico con dosis diluidas de vinazas. La investigación se realizó en la Universidad Nacional de Colombia Sede Palmira (3° 25'39.81"; N y 76° 25'45.70"; O, 953 m.s.n.m, 24 °C y 60% HR, 1.020 mm. Los dos métodos no difirieron de forma significativa (p<0.05 en la estimación de la conductividad hidráulica saturada promedio, la cual se redujo de forma exponencial al incrementar la concentración de vinaza. Los resultados obtenidos nos indican una reducción de la conductividad hidráulica del 50% para una concentración de vinaza de 2° Brix en un suelo arenoso, 5.3° Brix en el suelo franco arenoso y 6.1° Brix en el suelo franco arcilloso.Fall-related injuries among youth under 20 years old who were treated in Nicaraguan emergency departments, 2004 Lesiones relacionadas con caídas en menores de 20 años de edad que fueron tratados en departamentos de emergencias de Nicaragua, 2004

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    María de Lourdes Martínez-Trujillo

    2011-04-01

    Full Text Available OBJECTIVE: To describe the circumstances of fall-related injuries among youth 0-19 years treated in emergency departments in Nicaragua; to estimate the incidence rates (IR of falls; and, to identify areas for prevention efforts. MATERIAL AND METHODS: All patients OBJETIVO: Describir las lesiones relacionadas con caídas entre los niños y adolescentes menores de 20 años de edad que fueron tratados en departamentos de emergencia de Nicaragua, 2004. Describir las circunstancias y estimar la tasa de incidencia (TI de las caídas entre niños y adolescentes de 0-19 años atendidos en las salas de emergencia en Nicaragua. Además, identificar áreas dónde dirigir los esfuerzos de prevención. MATERIALES Y MÉTODOS: Se seleccionaron todos los pacientes (6593 de 0-19 años lesionados por caídas atendidos en emergencia por el Sistema de Vigilancia de Lesiones en 2004 en las ciudades de Managua, León, Jinotepe y Ciudad Sandino. RESULTADOS: En 2004, la TI para caídas en niños y adolescentes 0-19 años fue 104.2 por 10000 habitantes. La TI en varones fue dos veces más alta que en mujeres. Los principales objetos involucrados fueron árboles (23.3% y camas (15.2%. La principal naturaleza de lesión fue fractura (35.7%. CONCLUSIONES: Mobiliario, lugares de recreación y ambiente físico fueron las áreas identificadas. Desarrollar intervenciones incluyendo cambios en el ambiente del hogar y áreas recreacionales, así como programas educacionales, resulta muy útil para adolescentes y cuidadores.

  17. A profile of patients treated at a national leprosy outpatient referral clinic in Rio de Janeiro, Brazil, 1986-2007 Perfil de los enfermos tratados en un servicio nacional de remisión de pacientes ambulatorios con lepra en Río de Janeiro, Brasil, 1986-2007

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    Mariana A. Hacker

    2012-06-01

    Full Text Available OBJECTIVE: To analyze a profile of patients treated at a national leprosy outpatient referral clinic in metropolitan Rio de Janeiro, Brazil, over a period of more than two decades, and the subgroup of nationally registered leprosy cases from the same residential area, as well as all registered cases statewide. METHODS: An observational, descriptive analysis was carried out for patients treated from 1986 to 2007 at the Souza Araújo Outpatient Clinic (Ambulatório Souza Araújo, ASA, a national referral center for the diagnosis and treatment of leprosy at the Oswaldo Cruz Foundation (Fiocruz that serves clients from the city of Rio de Janeiro and other municipalities in the metropolitan area of Rio de Janeiro State. Demographic and clinical data for the subgroup of leprosy cases registered with Brazil's National Disease Notification System (Sistema Nacional de Informação de Agravos de Notificação, SINAN between 2001 and 2007 and residing in the same municipalities as the ASA patients, and for all registered cases statewide, were also analyzed. RESULTS: Among the ASA patients, there was a decrease in average family income (from 3.9 to 2.7 times the minimum salary between the periods 1998-2002 and 2003-2007; the proportion of multibacillary (MB patients (from 52.7% to 46.9%; and the proportion of patients younger than 15 years old (from 12.8% to 8.7%. Among the MB patients, the average initial and final bacilloscopic indices were significantly higher in 2003-2007. Compared with the SINAN cases, more ASA cases involved disability and were younger than 15 years old. CONCLUSIONS: Patients living with leprosy in the metropolitan area of the state of Rio de Janeiro belong to the most deprived social strata and have not benefited from the overall improvement in socioeconomic conditions in Brazil.OBJETIVO: Analizar el perfil de los enfermos tratados en un servicio nacional de remisión de pacientes ambulatorios con lepra ubicado en la zona

  18. Protocol Additional to the Agreement between the Government of the Republic of Ghana and the International Atomic Energy Agency for the Application of Safeguards in connection with the Treaty on the Non-Proliferation of Nuclear Weapons; Protocolo Adicional Al Acuerdo Entre La Republica De Ghana Y El Organismo Internacional De Energia Atomica Para La Aplicacion De Salvaguardias En Relacion Con El Tratado Sobre La No Proliferacion De Las Armas Nucleares

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-11-27

    The text of the Protocol Additional to the Safeguards Agreement concluded between the Government of the Republic of Ghana and the International Atomic Energy Agency for the application of safeguards in connection with the Treaty for the Non-Proliferation of Nuclear Weapons (NPT) is reproduced in this document for the information of all Members. The Additional Protocol was approved by the Board of Governors on 11 June 1998. It was signed in Vienna on 12 June 1998 [Spanish] Se transcribe en el presente documento, para informacion de todos los Estados Miembros, el texto del Protocolo adicional al Acuerdo de salvaguardias concertado entre la Republica de Ghana y el Organismo Internacional de Energia Atomica para la aplicacion de salvaguardias en relacion con el Tratado sobre la no proliferacion de las armas nucleares (TNP). El Protocolo adicional fue aprobado por la Junta de Gobernadores el 11 de junio de 1998 y firmado en Viena el 12 de junio de 1998.

  19. Perfil lipídico sérico de ratos tratados com surfactante

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    Karina Ferreira de Castro

    2012-06-01

    Full Text Available A aterosclerose é uma doença multifatorial, lenta e progressiva e a hiperlipidemia um dos fatores potenciais no desenvolvimento de doenças cardíacas ateroscleróticas. As vantagens da indução das dislipidemias experimentais são a produção de lesões ateromatosas em curto espaço de tempo; adequado controle dietético e fatores ambientais; a possibilidade de estudos sobre a reversibilidade de lesões ateroscleróticas e ensaios pré-clínicos de substâncias hipolipidêmicas. Este estudo visou avaliar o perfil lipídico sérico de ratos tratados com surfactante. Foram utilizados 28 ratos Wistar, machos, albinos, adultos e hígidos. Estes foram distribuídos em quatro grupos experimentais formados por sete animais cada, a saber: Grupo I – (controle; Grupo II – tratado com tyloxapol, na dose de 500 mg/kg de peso corporal, via intraperitoneal a cada 48 horas, durante duas semanas; Grupo III – tratado com tyloxapol na dose de 500 mg/kg de peso corporal, via intraperitoneal a cada 48 horas, durante três semanas; Grupo IV – tratado com tyloxapol na dose de 500 mg/kg de peso corporal, via intraperitoneal a cada 48 horas, durante quatro semanas. Na avaliação do perfil lipídico, os valores de triacilgliceróis e HDL demonstraram que o grupo III diferiu significativamente do grupo I e os valores de colesterol total e LDL indicaram que o grupo I diferiu significativamente dos grupos II, III e IV. Conclui-se que o surfactante tyloxapol foi efetivo na indução da hiperlipidemia.

  1. Morbilidad y mortalidad en una serie de pacientes con neoplasias del peritoneo, tratados con citorreducción peritoneal más quimioterapia hipertérmica intraperitoneal en el Hospital Universitario de la Fundación Santa Fe de Bogotá (ONCOLGroup - estudio ATIA

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    F. Arias

    2012-04-01

    Conclusiones: La cirugía citorreductiva más HIPEC en pacientes bien seleccionados con neoplasias las cuales afectan el peritoneo, resulta un procedimiento que se puede realizar en Colombia con un adecuado perfil de seguridad y eficacia. La mortalidad fue similar a lo reportado en la literatura mundial.

  2. Resultados clínico-radiológicos en pacientes jóvenes con fractura articular completa de radio distal tratados con placa palmar bloqueada. [Clinical and radiological results in young patients with complete articular distal radius fractures treated with volar locked plate.

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    Pablo De Carli

    2016-02-01

    Conclusión: El tratamiento de las fracturas de radio distal tipo C en pacientes jóvenes con placa palmar bloqueada muestra resultados clínicos y radiológicos favorables con corrección de la mayoría de los escalones articulares.

  3. El tratado de Derecho Administrativo del Profesor Rodolfo Carlos Barra

    Directory of Open Access Journals (Sweden)

    Daniel Hugo Martins

    2014-06-01

    Full Text Available En el "Tratado" cuyos primeros dos tomos han sido públicados recientemente, Barra se propone aplicar la "tesis cuatripartita" al derecho administrativo, con base en la "filosofía perenne" y la interpretación tomista del derecho."Este trabajo -dice- propugna la sistematización y mediatización del Derecho Administrativo, como rama del derecho público que garantiza el cumplimiento del acto justo en las relaciones de justicia distributiva y está referido a la regulación de la relación jurídica Estado (Administración Pública - administrado"

  4. El Tratado de Versalles y el huevo de la serpiente

    OpenAIRE

    Cruset, María Eugenia

    2009-01-01

    Si algo enseña la historia es que no hay verdadero y pacífico desarrollo sin verdad, justicia y reparación. O, dicho en sentido negativo, nada hay más explosivo y destructivo para cualquier país que las arbitrariedades e inequidades. Este año se cumplen 90 años de uno de los episodios más gráficos de lo que estamos diciendo: el Tratado de Versalles, que firmado el 28 de junio de 1919 significó el fin de la Primer Guerra Mundial con la humillante derrota de Alemania. Flagrante situación de arb...

  5. Posesión, retención y uso de mosquiteros tratados con insecticidas de larga duración luego de un año de su distribución en Loreto, Perú Long-lasting insecticide - treated bednet ownership, retention and usage one year after their distribution in Loreto, Peru

    Directory of Open Access Journals (Sweden)

    Angel Rosas-Aguirre

    2011-06-01

    Full Text Available Objetivos. Evaluar la posesión, retención y uso de mosquiteros tratados con insecticida de larga duración (MTILD luego de un año de su distribución en Loreto, Perú. Materiales y métodos. De julio a septiembre de 2007 se distribuyeron 26 185 MTILD Olyset Net® en 194 comunidades objetivo de Loreto, que protegieron a 45 331 personas. Posteriormente, se realizaron visitas de monitoreo (primera en diciembre de 2007 y segunda en julio de 2008 a los hogares de una muestra de 60 comunidades objetivo (30,9% del total, colectándose mediante un cuestionario semiestructurado los datos necesarios para el cálculo de indicadores de posesión, retención y uso de los MTILD. Resultados. En ambas visitas, la posesión de MTILD en hogares fue elevada (99,9% y 98,7%, respectivamente. La razón MTILD/persona disminuyó de 0,58 al momento de la distribución a 0,51 en la segunda visita, estimándose una retención al año de MTILD de 87%. En la primera visita, 99,0% de los niños Objectives. To assess long-lasting insecticide - treated bednet (LLITN ownership, retention and usage one year after their distribution in Loreto, Peru. Materials and methods. From July to September 2007, 26,185 LLITNs Olyset Net ® were delivered in 194 targeted communities in the Peruvian Amazon region, covering 45,331 people. Two cross-sectional community-based surveys in December 2007 and July 2008 were undertaken in a sample of 60 targeted communities (30.9% out of the total. A semi-structured questionnaire was used to collect necessary data to calculate LLITN ownership, retention and usage indicators. Results. High LLITN household ownership was showed in both surveys (99.9% and 98.7%, respectively. LLITN/ person ratio decreased from 0.58 at the end of the LLITN delivery to 0.51 in the second survey, estimating LLITN retention of 87% after 1 year of intervention. In the first survey, 99.0% of all children <5 years and 96,0% of pregnant women slept under a LLITN the previous

  6. Vinos, carnes, ferrocarriles y el Tratado de Libre Comercio entre Argentina y Chile (1905-1910)

    OpenAIRE

    Lacoste, Pablo

    2004-01-01

    Entre 1905 y 1910 Chile y Argentina negociaron la firma de un Tratado de Comercio con vistas a suprimir los aranceles aduaneros y consagrar el principio de "Cordillera Libre". El centro de atracción eran las exportaciones de ganado argentino a Chile y de vino chileno a Argentina. Pero en ambos países se produjo una fuerte reacción de los intereses creados con vistas a frustrar las tratativas diplomáticas. Tanto la Sociedad Nacional de Agricultura (Chile) como el Centro Vitivinícola Nacional (...

  7. Tratado de libre comercio entre Colombia e Israel. Perspectivas generales y oportunidades para el sector agrícola colombiano

    OpenAIRE

    Triviño Ortega, Sebastián; Prada Vanegas, Harold Sebastián

    2015-01-01

    Las estrategias tendientes a la diversificación de los mercados de exportación e internacionalización de la economía por parte del gobierno colombiano y sus políticas gubernamentales han incluido la firma de una serie de Tratados de Libre Comercio, entre ellos el TLC de última generación firmado con El Estado de Israel. Estos tratados además de abordar temas tradicionales de comercio, tratan nuevos capítulos en inversiones y servicios. Así mismo se analizan las principales políticas por parte...

  8. Un tratado sobre la extranjería de lo propio (El uruguayo de Copi

    Directory of Open Access Journals (Sweden)

    María Negroni

    2006-09-01

    Full Text Available El uruguayo de Copi es un tratado sobre la lengua, una descripción desopilante de un país, un ácido comentario político, una burla impiadosa de los valores culturales, una pesadilla personal, un golpe de teatro donde cualquier versión de la realidad se vuelve precaria y se trastoca al compás de una imaginación afiebrada que no hace más que dar rienda suelta a los materiales del inconsciente. Pero sobre todo, es la visión desnuda de la relación imposible de un escritor con el país que ha dejado atrás. Un tratado sobre el horror de confrontarse con la realidad carcelaria del pasado. Un intento de "calmar" los fantasmas, es decir, de hacerlos hablar y moverse y morir y resucitar en una trama que transita en medio de cadáveres y mares desaparecidos y un territorio que se achica constantemente. Un texto fundamental para indagar cuestiones relacionadas con la "identidad" nacional y con las maneras en que los desplazamientos culturales (con su concomitante tránsito entre lenguas y visiones del mundo, tan comunes en el mundo actual, afectan la escritura.

  9. Agreement of 30 January 1992 between the Government of the Democratic People's Republic of Korea and the International Atomic Energy Agency for the Application of Safeguards in connection with the Treaty on the Nonproliferation of Nuclear Weapons; Acuerdo De 30 De Enero De 1992 Entre El Gobierno De La Republica Popular Democratica De Corea Y El Organismo Internacional De Enercia Atomica Para La Aplicacion De Salvaguardias En Relacion Con El Tratado Sobre La No Proliferacion De Las Armas Nucleares

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-05-15

    The text of the Agreement between the Government of the Democratic People's Republic of Korea and the International Atomic Energy Agency for the application of safeguards in connection with the Treaty on the Non-Proliferation of Nuclear Weapons is reproduced in this document for the information of all Members. The Agreement was approved by the Agency's Board of Governors on 12 September 1991 and signed in Vienna on 30 January 1992. The Agreement entered into force, pursuant to Article 25, on 10 April 1992 [Spanish] El texto del Acuerdo entre el Gobierno de la Republica Popular Democratic-a de Corea y el Organismo Internacional de Energia Atomica para la aplica cion de salvaguardias en relacion con el Tratado sobre la no proliferacion de las armas nuclearese reproduce en este documento para informacion de to dos los Estados Miembros. El Acuerdo fue aprobado por la Junta de Gobernado res del Organismo el 12 de septiembre de 1991 y firmado en Viena el 30 de ene ro de 1992.

  10. Comportamiento de la TSH y la T4 en una cohorte de pacientes con arritmia cardiaca tratados con amiodarona u otros antiarrítmicos Behavior of TSH and T4 in a cohort of patients with cardiac arrhythmia treated with amiodarone or other antiarrhythmics

    Directory of Open Access Journals (Sweden)

    Erwing A Vargas

    2008-08-01

    Full Text Available La amiodarona es uno de los antiarrítmicos de uso más extendido, pero de la misma forma es un medicamento con efectos adversos bien conocidos y a múltiples niveles; uno de los más importantes es el que se describe para el tejido tiroideo. Cerca de 80% de los pacientes que la toman de forma indefinida, presentarán algún efecto adverso; sin embargo, menos de 15% la suspenderán. En la glándula tiroides, los mecanismos de lesión se relacionan, por su semejanza estructural, con la levotiroxina, la liberación de altas concentraciones de yodo y la inducción de reactividad inmune, entre otras. No obstante, la mayoría de los pacientes permanece eutiroideos. Este estudio describe la variación de la función tiroidea a corto plazo, en 77 pacientes que recibieron diferentes tipos de antiarrítmicos, que no tenían factores de riesgo asociados a disfunción tiroidea, y que se reclutaron en el servicio de hospitalización. Se tomaron muestras de TSH al inicio y al cabo de tres meses de seguimiento. Se observaron niveles de TSH normales en 26% (43 pacientes y tendencia a valores más altos en el control al tercer mes en el grupo medicado con amiodarona. De manera adicional, se describió una proporción mayor de trastornos de la función de la glándula tiroides en la población masculina.Aminodarone is one of the most widespread used antiarrhythmics, but in the same way it is a medicine with well known side-effects at multiple levels; one of the most important ones is described for the thyroid tissue. Almost 80% of patients that receive it for an indefinite time will present an adverse effect; nevertheless, only less than 15% will discontinue it. Injury mechanisms are related, because of its structural similitude, to those of levothyroxine, with liberation of high iodine concentrations and induction of immune reactivity, among others. However, most patients remain in euthyrod state. This study describes thyroid function variation at short term in

  11. Aceros sinterizados tratados al vapor para la fabricación de componentes de amortiguadores bitubo

    Directory of Open Access Journals (Sweden)

    Cambronero, L. E. G.

    2000-06-01

    Full Text Available In this work, properties of three sintered and steam treated alloyed irons were analysed. These materials were Fe+2Cu, Fe+0.6C+0.5Cu, and Fe+0.45P+2.5Cu, which were obtained by powder mixing. Once pressed and sintered, samples were steam treated (surface treatment which is characteristic of sintered irons. Density, hardness and tensile strength were obtained on sintered and steam treated samples, within their microstructure analysis. Also, a tribological study was carried out since some parts of shock absorbers are working under friction.

    En este trabajo se analizan las propiedades de tres hierros aleados sintetizados y tratados al vapor. Los materiales seleccionados son el Fe+2Cu, Fe+0.6C+0.5Cu, y Fe+0.45P+2.5Cu, obtenidos por mezcla elemental de polvos. Una vez compactados y sintetizados, se sometieron a un tratamiento de recubrimiento característico de los hierros, como es el tratamiento al vapor. En los materiales sintetizados y tratados al vapor, se determinaron su densidad, dureza y resistencia a tracción, junto con su análisis microestructural. Así mismo dado que algunos de los componentes de los amortiguadores bitubo están sometidos a esfuerzos de fricción, se analizaron el comportamiento tribologíco de los materiales obtenidos tanto en estado sintetizado como tratados al vapor.

  12. Cutaneous Cancers in Nigerian Albinos: A Review of 22 Cases

    African Journals Online (AJOL)

    2018-04-20

    Apr 20, 2018 ... this protective pigment in albinos predisposed them to sunburns and subsequent ... The most common of the skin cancers documented among the albinos ..... hats, application of sunscreen creams and always using umbrella ...

  13. El comercio electrónico en los tratados de libre comercio de México

    OpenAIRE

    Sigmond, Karen

    2018-01-01

    Resumen: Este artículo iniciará con los antecedentes del desarrollo del régimen del derecho commercial internacional, desde el Acuerdo General sobre Aranceles Aduaneros y Comercio a la Organización Mundial del Comercio. Se definirá al comercio electrónico o E-commerce y se hará una referencia de las tendencias de crecimiento actuales, seguida de la manera en la que se regula esta materia en México. Se estudiará la cobertura del comercio electrónico en los Tratados de Libre Comercio de México,...

  14. seed on haematological parameters of albino rats

    African Journals Online (AJOL)

    Dr Ejere

    2015-06-23

    Jun 23, 2015 ... and its indices (haemoglobin content, pack cell volume, mean corpuscular volume, mean corpuscular haemoglobin ... demands in plant-based proteins for humans and livestock, ... hypogea) and animal based proteins (Siddhuraju et al.,. 1995 ..... difference in the packed cell volume (PCV) of albino rats.

  15. El Sistema del Tratado Antártico, Posición de Chile como País Puente

    Directory of Open Access Journals (Sweden)

    Javier Urbina Paredes

    2009-10-01

    Full Text Available El artículo presenta al Tratado Antártico y al sistema y régimen internacional a que da lugar, a cincuenta años de su firma en Washington, Estados Unidos, el 1 de diciembre de 1959. Los retos de la época y los propósitos del Tratado fueron satisfactoriamente superados, pero hoy se enfrenta a nuevos problemas y desafíos, no tanto de carácter político, sino científico, derivados sobre todo del cambio climático, la creciente actividad turística, el daño al medio ambiente y la seguridad de la navegación marítima y aérea. Chile es un actor clave en la Antártida y en el sistema del Tratado Antártico y ofrece sus potencialidades como país puente al ser el más cercano al continente para el desarrollo de las actividades antárticas en general. En su vinculación internacional sobre la materia, lo hace bajo el marco del Tratado Antártico, pero más aún, desarrolla capacidades concretas de acuerdo con las mayores y nuevas demandas que el sistema antártico deberá enfrentar para ponerlas a disposición de la comunidad internacional.

  16. Adición de residuos de yeso laminado tratado, en el yeso de construcción.

    OpenAIRE

    Rodriguez Orejón, Agustín

    2011-01-01

    Este trabajo tiene por objeto analizar la posibilidad de utilización de los RCD’s derivados de las placas de yeso laminado (PYL) de forma específica por mezcla de una matriz de yeso o escayola en polvo de nueva producción, con diferentes proporciones de estos residuos, previamente tratados. Por otro lado estudiar la cuantificación de la minoración de resistencia mecánica, sufrida por matrices de diferentes tipos de yeso con agregados, en distintas proporciones, a base de RCD`s de paneles ...

  17. Tratado de Libre Comercio de América del Norte, territorio financiero del libre comercio

    Directory of Open Access Journals (Sweden)

    Margarita Camarena Luhrs

    2014-09-01

    Full Text Available A veinte años de la firma del Tratado de Libre Comercio de Norteamérica, posiblemente ha agotado sus posibilidades. De sus objetivos, los que resultaron viables, fue la constitución de un territorio financiero de libre comercio, libre y continuo en Norteamérica. Con este proceso destaca el imperativo financiero de la expansión comercial trilateral; pero también, tal como se muestra con esta reflexión, que tras esos resultados comerciales opera una inteligencia financiera y territorial, realmente geoestratégica, promotora de extrema “liberalización proteccionista” que traspasa y supera las capacidades nacionales de Estados.

  18. Proceso de negociación del tratado sobre el comercio de armas: tensiones y dinámicas de poder

    OpenAIRE

    del Castillo Briceño, Paula Johana

    2014-01-01

    El interés del presente estudio de caso es analizar la articulación de las dinámicas de poder y estrategias de negociación detrás de un proceso tan complejo como el de la creación del Tratado sobre el Comercio de Armas.El estudio examina la evolución de las tensiones principales entre los Estados participantes frente al Tratado y resalta las lógicas de poder al interior de las negociaciónes, así como los factores externos que influyeron para solucionar o agravar dichas tensiones. Con el apoyo...

  19. Esquistossomose: 1.000 pacientes tratados

    Directory of Open Access Journals (Sweden)

    Pedro Aquino Noleto

    1974-12-01

    Full Text Available Os autores relatam sua experiência com o hycanthone em 1.000 pacientes de esquistossomose mansônica, até agora tratados no Hospital de Clínicas da Universidade do Estado da Guanabara. São pacientes oriundos de áreas endêmicas do País, especialmente do nordeste e sudeste, 53,9% do sexo masculino e 46,1% do sexo feminino, de idade entre 5 e 63 anos. A forma clínica predominante da parasitose foi a hépato-intestinal (96,8%. O medicamento foi administrado em dose única, na razão de 3 mg/kg de peso corporal, a 33.6% de pacientes internados e a 66 4% em regime de tratamento ambulatorial. Os níveis séricos das transaminases, determinados, para confronto, antes e depois do uso do produto, em 60 dos pacientes internados, não se alteraram, ou apenas sofreram elevações inexpressivas. Não houve efeitos colateriais em 42,3% dos pacientes. Nos demais, esses efeitos foram de pequena e média intentidade, duraram apenas o 19 dia, na maioria das vezes, e consisfram, especialmente, de náuseas e de vômitos. O controle de cura parasitária estabelecido compreendeu 4 exames de fezes - aos 30, 60, 90 e 120 dias do emprego do medicamento, o que já se fez em 330 pacientes (33%, com 99% de cura. Incluída a biópsia retal, sempre que foi possivel, por ocasião do 4º exame de fezes, o esquema funcionou até agora em 97 pacientes (9,7%, dos quais 92 (94% estão curados, segundo esse critério. O presente trabalho confirma a ação esquistossomicida do hycanthone, bem como sua boa tolerabilidade, inclusive no que se refere ao hepatócito. Os doentes, entretanto, devem ser criteriosamente selecionados, tendo-se em vista as contra-indicações conhecidas, de modo especial em relação ao fígado.

  20. Embarazo cornual: tratamiento médico con dosis única de metotrexato

    OpenAIRE

    Ricci A,Paolo; Troncoso J,José Luis; Avilés L,Guillermo; Avilés D,Raimundo

    2013-01-01

    Presentamos un caso de embarazo cornual o intersticial diagnosticado en forma precoz a través de ecografía transvaginal, tratado exitosamente, en forma conservadora, con dosis única sistémica de metotrexato.

  1. Efecto de los Tratados de Libre Comercio, Acuerdos Comerciales y Tratados Bilaterales de Inversión sobre los Flujos de Inversión Extranjera Directa: un análisis para América Latina entre 2001-2014

    OpenAIRE

    Dávila Barragán, Jimena Alejandra; Orozco Jaramillo, Camilo

    2015-01-01

    Este documento investiga los efectos que tienen los Tratados de Libre Comercio (TLC), demás Acuerdos Comerciales (AC) y Tratados Bilaterales de Inversión (TBI) sobre los flujos de Inversión Extranjera Directa (IED), por medio de un pseudo - panel conformado por un total de total de 960 individuos (construidos con país de origen y de destino) para 15 países de América Latina durante el período 2001-2014 -- Los resultados sugieren que los TLC no incluyen en los flujos de IED que ingresan a Amér...

  2. Evaluación tomográfica y radiográfica de la obturación radicular tridimensional de conductos radiculares únicos tratados con tres técnicas de obturación radicular: Estudio in Vitro

    Directory of Open Access Journals (Sweden)

    Mónica Alexandra Pavón Granja

    2016-09-01

    Full Text Available El principal reto durante la terapia endodóntica es la obturación radicular, considerada como fase crítica ya que de esta va a depender el éxito o el fracaso. Por varios años se ha investigado tanto materiales como técnicas que permitan el sellado hermético tridimensional del sistema de conductos radiculares, biocompatibilidad que permita la adecuada reparación de los tejidos periapicales y que la obturación se mantenga con el tiempo proporcionando salud. Objetivo: Evaluar la adaptación tridimensional de tres técnicas de obturación radicular definitiva a nivel del tercio apical de conductos radiculares únicos. Materiales y métodos: Estudio de tipo experimental y aleatorizado, la muestra fue de 42 raíces de dientes uniradiculares divididos en 3 grupos de estudio (n=14, previamente se realizó un registro radiográfico periapical digital de toda la muestra posteriormente fueron instrumentados con técnica hibrida, desinfectados con NaOCl al 5,25% + activación ultrasónica y EDTA al 17%, GA fue sometido a técnica de obturación lateral en frío, GB aplicado técnica de obturación termomecánica McSpadden y GC se obturó con técnica termoplastificada (BeFill-VDW. Resultados: Los grupos C y B observados a través de tomografía computarizada presentaron mejores resultados de obturación radicular que el grupo A que no presentó un buen sellado apical, sin embargo, en el grupo C se observó mejores resultados que en A y B Conclusiones: Las técnicas de obturación radicular definitivas con la técnica termoplastificada mostraron ser ideales para proporcionar un sellado apical hermético durante el tratamiento endodóntico en la fase de obturación

  3. How does agonistic behaviour differ in albino and pigmented fish?

    Directory of Open Access Journals (Sweden)

    Ondřej Slavík

    2016-04-01

    Full Text Available In addition to hypopigmentation of the skin and red iris colouration, albino animals also display distinct physiological and behavioural alterations. However, information on the social interactions of albino animals is rare and has mostly been limited to specially bred strains of albino rodents and animals from unique environments in caves. Differentiating between the effects of albinism and domestication on behaviour in rodents can be difficult, and social behaviour in cave fish changes according to species-specific adaptations to conditions of permanent darkness. The agonistic behaviours of albino offspring of pigmented parents have yet to be described. In this study, we observed agonistic behaviour in albino and pigmented juvenile Silurus glanis catfish. We found that the total number of aggressive interactions was lower in albinos than in pigmented catfish. The distance between conspecifics was also analysed, and albinos showed a tendency towards greater separation from their same-coloured conspecifics compared with pigmented catfish. These results demonstrate that albinism can be associated with lower aggressiveness and with reduced shoaling behaviour preference, as demonstrated by a tendency towards greater separation of albinos from conspecifics.

  4. El tratado secreto del Barón de Río Branco: la alianza entre Brasil y Ecuador, 1904

    Directory of Open Access Journals (Sweden)

    Luís Cláudio Villafañe G. Santos

    2016-06-01

    Full Text Available Es casi desconocida en las historiografías de Brasil y Ecuador la existencia de un tratado militar secreto entre ambos países, rmado el 5 de mayo de 1904, dirigido contra las pretensiones territoriales de Perú. El artículo estudia una creciente tensión entre Brasil y Perú, que disputaban un área de 442 mil kilómetros cuadrados en la Amazonía. Por iniciativa del Barón de Río Branco, se rmó un tratado secreto de alianza militar entre Brasil y Ecuador. Si bien este acuerdo no fue raticado por los países rmantes, fue de suma importancia para forzar al gobierno peruano a iniciar negociaciones con Brasil, que años más tarde resultaron en el tratado de límites entre los dos países.

  5. Frecuencia de Síntomas de Depresión en Pacientes Adolescentes con Epilepsia. Tratados en el Servicio de Consulta Externa de la Fundación Hospital de la Misericordia y Fundación Liga Central Contra La Epilepsia

    Directory of Open Access Journals (Sweden)

    Carolina Ñungo

    2009-07-01

    Full Text Available

    *Este artículo está basado en la tesis de especialización de Carolina Ñungo bajo la dirección del segundo y tercer autor. Fragmentos de este artículo fueron presentados como poster en el XIV Congreso Nacional de Epilepsia en Medellín, Colombia, Septiembre de 2008.

    Resumen

    La epilepsia es una condición neurológica crónica que debido a su etiología, mecanismo fisiopatológico, a la clínica y al tratamiento tiene importantes repercusiones en el estado biopsicosocial de las personas que la padecen. En las últimas décadas se ha llamado la atención hacia el deterioro mental, emocional y en general en la calidad de vida de estos pacientes al padecer diferentes trastornos psicológicos. El tipo de comorbilidad psiquiátrica que con mayor frecuencia se diagnóstica en los pacientes con epilepsia es el trastorno depresivo.

    Este estudio permite demostrar que la frecuencia de síntomas de depresión en un grupo de adolescentes entre 13 y 17 años con epilepsia es 4 veces mayor al compararlos con un grupo de personas de la misma edad sin epilepsia. Además el padecer epilepsia es el factor de asociación más importante para presentar síntomas depresivos de forma independiente con respecto a la edad o estrato socioeconómico.

    Debido al tamaño de la muestra (90 pacientes no se pudieron encontrar diferencias estadísticamente significativas con respecto a los distintos tipos de epilepsia, su evolución y tratamiento, aunque se hallo una mayor tendencia a la depresión en aquellos pacientes con diferentes tipos de crisis (focales y generalizadas, con epilepsia mal controlada y los que requieren politerapia.

    Este el primer estudio en adolescentes realizado en nuestro país que demuestra la relevancia que tiene este tipo de trastornos en nuestros pacientes como se había demostrado en otros estudios a nivel mundial.

    Palabras clave Síntomas depresivos

  6. Vinos, carnes, ferrocarriles y el Tratado de Libre Comercio entre Argentina y Chile (1905-1910

    Directory of Open Access Journals (Sweden)

    Pablo Lacoste

    2004-06-01

    Full Text Available Entre 1905 y 1910 Chile y Argentina negociaron la firma de un Tratado de Comercio con vistas a suprimir los aranceles aduaneros y consagrar el principio de "Cordillera Libre". El centro de atracción eran las exportaciones de ganado argentino a Chile y de vino chileno a Argentina. Pero en ambos países se produjo una fuerte reacción de los intereses creados con vistas a frustrar las tratativas diplomáticas. Tanto la Sociedad Nacional de Agricultura (Chile como el Centro Vitivinícola Nacional (Argentina realizaron intensas gestiones para alcanzar sus objetivos; esta última corporación llegó a movilizar miles de personas para oponerse al tratado; y hasta solicitó ayuda a los ferrocarriles británicos para que obstaculizaran el ingreso de los vinos chilenos al mercado argentino. La intensa resistencia de estas corporaciones terminaron por frustrar el proyecto, el cual fue definitivamente archivado en 1911.Between 1905 and 1910, Chile and Argentina negotiated the signature of a Trade Agreement in order to abolish the customs duties and consecrate the principle of "Free Mountain Range". The centre of attraction was the exports of Argentinean cattle to Chile and of Chilean wine to Argentina. But in both countries there aroused a strong reaction of the vested interests, purposely to thwart the diplomatic negotiations. Both, the Sociedad Nacional de Agricultura (Chile as well as the Centro Vitivinícola Nacional (Argentina carried out intense negotiations to reach their objectives; the latter even movilized thousands of people to oppose the treaty and went as far as requesting the help of the British railroads to block the entrance of Chilean wines to the Argentinean market. The stiff opposition of these corporations finally frustrated the project, which was definitively filed away in 1911.

  7. Behaviour of enzymatic activities and root elongation in Argiudoll soils from the Argentine Humid Pampa treated with biosolids Comportamiento de actividades enzimáticas y elongación de raíces en suelos Argiudoles de la Pampa Húmeda, Argentina, tratados con biosólidos

    Directory of Open Access Journals (Sweden)

    E.B.R. Perotti

    2008-06-01

    Full Text Available The incorporation of biosolids to soil is a strategy aiming at the re-location of these materials in the environment with a useful end: soil fertilization. In this work, the response of two Argiudoll soils (one with more than 100 years of agriculture and the other, a virgin one to biosolid incorporation was studied under laboratory conditions. To measure this response, soil enzymatic biodescriptors, such as dehydrogenase and urease activities, and tests related to plant physiology (the root elongation test were employed. The addition of the biosolid to both soils had a stimulating effect though different on each soil according to the added dose. Adjustment of the regression line for dehydrogenase activity with root elongation was positive and statistically significant (pLa incorporación de biosólidos al suelo es una estrategia que tiene como objetivo la reubicación de estos materiales en el ambiente con un fin útil, como es la fertilización del suelo. En este trabajo se estudió, en condiciones controladas de laboratorio, la respuesta de dos suelos Argiudoles (uno con más de 100 años de agricultura y otro virgen frente a la perturbación físico-química y biótica que genera la incorporación de un biosólido. Para medir esta respuesta se emplearon dos biodescriptores edáficos (las actividades deshidrogenasa y ureasa y un tercero referido a la fisiología vegetal, la prueba de elongación de raíces. La incorporación del biosólido en ambos suelos, en general no deprimió el funcionamiento de las actividades enzimáticas estudiadas; contrariamente, según la dosis aportada tuvo un efecto estimulante, aunque diferente, entre ambos suelos. El ajuste de la recta de regresión de la actividad deshidrogenasa con la elongación de las plántulas fue positivo y altamente significativo, lo que indica la complementaridad de ambos descriptores. Los resultados obtenidos sugieren que los biodescriptores empleados resultaron aptos para estudiar el

  8. EL TRATADO DE LIBRE COMERCIO EN LOS DISCURSOS DE LOS CULTIVADORES DE TRIGO EN YACUANQUER-NARIÑO

    OpenAIRE

    Burbano Huertas, Luis Felipe; Ortega Vera, César Mauricio

    2015-01-01

    A finales del siglo XX Colombia ha ingresado paulatinamente en los procesos de libre comercialización con otros países, derivados de las dinámicas del mercado a nivel internacional; entre estos se encuentran el de la apertura económica en la década de los noventa y en la actualidad, el Tratado de Libre Comercio (TLC). El TLC, ha sido objeto de una serie de inconformidades planteadas por parte de algunos sectores económicos, como es el caso de los cultivadores de trigo en todo el país y partic...

  9. Tocando a las puertas del cielo. México y la negociación del Tratado de Libre Comercio

    OpenAIRE

    Orozco-Martínez, Carlos E.

    1992-01-01

    Análisis de la iniciativa de Carlos Salinas de Gortari como presidente de México para la creación de un área libre de comercio con Estados Unidos y Canadá. Se hace una radiografía de lo negociado para el Tratado de Libre Comercio, como acceso a mercados, reglas de comercio, servicios, inversión y propiedad intelectual; se repasa lo visto en materia de aranceles, agricultura, industria automotriz, industria textil y petroquímica, entre otros. Incluye obra visual de Francisco Madrigal, reproduc...

  10. Los potenciales impactos del tratado de libre comercio Estados Unidos-Ecuador en el sector agrícola

    OpenAIRE

    Calvache Peña, Myriam Patricia; Zambrano Illescas, José Sigifredo

    2008-01-01

    El presente trabajo analiza las ventajas y desventajas, así como los potenciales impactos de la firma del tratado de libre comercio con Estados Unidos, en el sector agrícola ecuatoriano. Se trata de abordar este tema a través de una exposición técnica de datos y de la experiencia internacional existente, lo que lleva a un enfoque más profundo de las grandes asimetrías que se tiene en el país del norte, en donde los agricultores reciben beneficios tanto en la producción como en la exportación,...

  11. Tránsito del Derecho Penal Internacional desde el Tratado de Versalles y de Nuremberg hasta Roma

    OpenAIRE

    Castaño, Deissy Motta

    2012-01-01

    El marco del presente artículo se sustenta en la trascendencia del análisis de las instituciones internacionales en relación con los delitos contemplados como crímenes de guerra en conflagraciones entre Estados y su intervención en la problemática de la violencia interna. El tránsito del derecho penal internacional desde el Tratado de Versalles y de Nuremberg hasta Roma, constituye una aproximación a una genealogía histórica del derecho internacional, relativo a los crímenes de guerra durante...

  12. Los tratados silogísticos de Boecio: sus fuentes, historia e influencia en la cristiandad latina

    Directory of Open Access Journals (Sweden)

    Manuel Correia

    2007-01-01

    Full Text Available En este artículo se describen los contenidos de un tratado sobre lógica aristotélica escrito por Boecio en el VI d. C, llamado por nuestras ediciones modernas De syllogismo categórico (=DSC. A través de sus contenidos, es posible mostrar: (i la importancia de este tratado en el proceso de transmisión de la lógica de Aristóteles al medioevo latino; (ii su relación con otro tratado monográfico similar, titulado por la crítica moderna Introductio ad syllogismos categóricos (ISC y su relación temática con DSC; (iii las fuentes más probables de ambos tratados; y, finalmente, (iv su influencia en el medioevo latino. La hipótesis que se defiende en este artículo es que los contenidos lógicos de este tratado, en particular la clasificación de las proposiciones categóricas, contenida en el corazón del DSC, entregan no solo el objeto temático al tratado, sino también coherencia argumentativa y unidad. En especial, el estudio de esta clasificación permite demostrar la unidad de DSC y en particular que el segundo libro de DSC es genuino y no espurio como sostuvieron, no hace mucho, los estudiosos Murari y McKinlay; además, esta misma clasificación permite apreciar su diferencia con ISC, por el hecho de que este último tratado posee una clasificación diferente a la de DSC. La base de la hipótesis propuesta se halla en que la clasificación mencionada es un intento por generar, a partir de los elementos preposicionales, las principales operaciones lógicas definidas por Aristóteles en sus escritos lógicos, asunto que en la revisión de De Rijk (1964 no quedó totalmente establecidoIn this article, the author describes the contents of a treatise on Aristotelian logic, written by Boethius in the sixth century A.D., titled in our modern editions as De syllogismo categórico (DSC. It is possible to show, through the contents: (i the importance of this treatise for the transmission process of Aristotle's logic to the Latin medieval

  13. Tratamiento de la anorexia urémica con acetato de megestrol

    OpenAIRE

    Fernández Lucas, M.; Teruel, J.L.; Burguera, V.; Sosa, H.; Rivera, M.; Rodríguez Palomares, J.R.; Marcén, R.; Quereda, C.

    2010-01-01

    Introducción: La anorexia es un trastorno frecuente en el enfermo tratado con hemodiálisis periódica, y factor contribuyente de la malnutrición. El objetivo del presente trabajo es comprobar la eficacia del acetato de megestrol, un estimulador del apetito utilizado en enfermos con cáncer, como tratamiento de la anorexia del enfermo sometido a diálisis. Material y métodos: En el año 2009, 16 enfermos de nuestra unidad de hemodiálisis, tres de ellos con diabetes mellitus, fueron tratados con ac...

  14. Anticonvulsant activity of Granisetron in Albino mice

    Directory of Open Access Journals (Sweden)

    Sathisha Aithal

    2015-05-01

    Full Text Available The objective of this study was to investigate the anticonvulsant activity of  5-HT3 antagonist, granisetron in albino mice. In this study granisetron (0.5mg/kg, i.p. was administered 30 minutes prior to application of electroshock (60mA, 02.seconds or administration of pentylenetetrazole. Granisetron significantly reduced the duration of tonic hind limb extension in maximum electroshock seizure (MES test. In pentylenetetrazole (PTZ test, granisetron delayed the onset and the decreased the duration of convulsions compared to control group. The percentage of animals protected in MES and PTZ  models were 66 and 83 respectively. The results showed that granisetron at dose of 0.5mg possess anticonvulsant activity in both MES and PTZ models.

  15. Influencia del marco regulatorio de los productos farmacéuticos en la salud pública. Análisis a partir de la ratificación por Colombia del Convenio ADPIC y de los Tratados de Libre Comercio con los Estados Unidos y la Unión Europea

    Directory of Open Access Journals (Sweden)

    Fernando Jiménez Valderrama

    2013-01-01

    Full Text Available Este artículo tiene por objetivo estudiar la relación entre la disponibilidad, los precios de los medicamentos y los intereses de salud pública. Para ello hemos utilizado una metodología de análisis de los intereses económicos implicados y también un método sistemático de tratamiento de la legislación nacional, comunitaria andina e internacional vigente. Igualmente hemos acudido a metodologías de derecho comparado entre nuestro ordenamiento jurídico nacional con los de otros países de mundo occidental. Existe un estrecho vínculo entre la disponibilidad y los precios de los medicamentos y los intereses de salud pública. Nuestro actual sistema legal reconoce a los inventores de nuevos medicamentos como un “monopolio” para negociar en el mercado farmacéutico. Para proteger los intereses públicos nuestra regulación establece algunos límites a los derechos de los inventores. Los derechos de propiedad se limitan en el tiempo y bajo algunas circunstancias es obligatorio autorizar a otros a usar la patente bajo un contrato de licenciamiento. La Organización Mundial del Comercio ha establecido (Decisión del Consejo de la OMC, Ronda Doha 2003 otros límites a estos derechos en caso de condiciones excepcionales. Nuestra Constitución Nacional otorga prevalencia a los intereses públicos sobre los privados. Es un deber de los gobiernos establecer un sistema justo en el cual los inventores puedan obtener una recompensa económica por sus creaciones y la sociedad pueda satisfacer sus necesidades de salud.

  16. Pretextos y contextos olvidados : arte, ciencia y técnica en algunos tratados contables de la Inglaterra Tudor

    Directory of Open Access Journals (Sweden)

    Juan Lanero Fernández

    2009-06-01

    Full Text Available El presente estudio pretende ver, desde una perspectiva amplia, los dos tratados de James Peele (1553, 1569. The pathe waye (1569, en su conjunto, se aparta de forma considerable de los tratados publicados con anterioridad; y por lo que se refiere a su primer libro (1553, dispone de suficientes rasgos diferenciadores para que en el todo y en las partes sea una pieza bien distinta de tratados anteriores. Algunos detalles de The maner and fourme provienen directamente de Pacioli o a través del primer tratado inglés de partida doble, obra de Hugh Oldcastle (1543, o de Ympyn. La influencia de éste, por su tratado holandés/francés (1543 y la traducción inglesa (1547, se aprecia en The pathe waye en el cierre del Libro Mayor y en la forma que ambos tienen de tratar las operaciones de trueque. Es un hecho que Manzoni (1540 está presente en The moner and fourme en lo tocante a la numeración de las partidas en el Diario y a su referencia en el texto. Por lo que se refiere a la organización de los libros de cuentas, también existen resonancias de Weddington. La excelencia es la cualidad que destaca en los dos tratado, en particular en The pathe waye. Peele supo recoger en sus libros las tendencias más innovadoras de la partida doble provenientes de los autores que le precedieron. Está demostrado que Mellis manejó, aunque no siempre de forma apropiada, los tratados de Peele para su reedición de Oldcastle (1588. Y se puede decir lo mismo de John Carpenter (1632. Pele comprendió los verdaderos principios de la partida doble; pero sus excelentes tratados se quedaron injustamente olvidados en la penumbra de los pretextos, la competencia de los contextos y casi ningún paratexto que los valorara en su justiprecio que fue, y sigue siendo, elevado.The present paper tries to have a look, from a broad perspective, at James Peele's two treatises (1553, 1569. The pathe waye (1569, as a whole, drifts away considerably from the treatises previously

  17. Biochemical and Haematological Indices of Weanly Albino Rats Fed ...

    African Journals Online (AJOL)

    acer

    ABSTRACT: Malnutrition is a public health problem in Nigeria accounting for more than 50% of ... weanly albino rats using nutritional, biochemical ... groundnut (16%), soy beans (16%), crayfish ... consumption was observed in rats on PC and.

  18. Estudio comparativo de las medidas transitorias de protección al sector agrícola en los tratados de libre comercio suscritos entre Estados Unidos de América (EEUU) – Colombia y Estados Unidos de América (EEUU) – Chile

    OpenAIRE

    Barón Martín, Erika Andrea; Vargas Pulido, Wiiliam Ernesto

    2016-01-01

    La suscripción de tratados de libre comercio (TLC) por parte de Estados Unidos (EEUU) durante la última década con países suramericanos ha correspondido a una estrategia implementada por este país para acercase al continente y mantener relaciones comerciales más estrechas con sus aliados estratégicos. Sin embargo, las negociaciones de estos tratados de libre comercio, suscritos con países suramericanos como Chile y Colombia han incluido medidas transitorias de protección, en especial en el s...

  19. Food Color Induced Hepatotoxicity in Swiss Albino Rats, Rattus norvegicus

    OpenAIRE

    Saxena, Beenam; Sharma, Shiv

    2015-01-01

    Objective: Certain dietary constituents can induce toxicity and play a critical role in the development of several hepatic disorders. Tartrazine, metanil yellow and sunset yellow are widely used azo dyes in food products, so the present study is aimed to investigate the food color induced hepatotoxicity in Swiss albino rats. Materials and Methods: Swiss albino rats were divided into four groups, each group having six animals. Group I served as control, Group II, Group III and Group IV were ad...

  20. Reconocimiento Mapu-Che de Chile: Tratado ante Constitución, Historia frente a Derecho

    Directory of Open Access Journals (Sweden)

    Bartolomé CLAVERO SALVADOR

    2011-04-01

    Full Text Available Desde el año 1991, el compromiso adquirido por los sucesivos gobiernos chilenos para reconocer a nivel constitucional la presencia indígena en el ordenamiento del Estado ha puesto de manifiesto el desconocimiento académico y jurídico mutuo por parte de Chile con respecto a las evidencias para una reposición de Mapu-Che. El presente trabajo hace un recorrido histórico y jurídico por las formas de relación entre el Estado chileno y el Estado Mapu, que hasta la conquista chilena de Mapu en la década de los ochenta del siglo XIX se manifestaron a través de Tratados y Parlamentos que implicaban un reconocimiento mutuo de ambas entidades en una esfera internacional. Las comisiones de estudios, informes oficiales e invocaciones de verdad para un nuevo trato, primero de las Naciones Unidas, y después de la República de Chile, han observado estas evidencias de la significación constitucional e internacional de los Tratados, pero Chile ha convertido su peculiar forma de reconocimiento constitucional de la presencia indígena en un alarde de unidad e indivisibilidad nacional. Este encubrimiento nace del deseo de mantener una Constitución exclusiva, al que se une la certeza de que otra forma de reconocimiento obligaría a un replanteamiento de las propias raíces de los fundamentos constitucionales de la República de Chile.

  1. El Tratado de Asunción y el Mercosur

    Directory of Open Access Journals (Sweden)

    Miguel Berthet

    2015-10-01

    Full Text Available Texto de la conferencia pronunciada por el Embajador Dr. Miguel Berthet -Director de Relaciones Económicas Internacionales Y de Comercio Exterior de los Ministerios'de Relaciones Exteriores y de Economía y Finaszas- en nuestra Facultad. el 25 de abril de 1991, explicando el significado y alcance del Tratado de Asunción. ,suscrito pocos dias antes de esta exposición. La conferencia estuvo principalmente orientada a dar nociones básicas para los estudiantes

  2. The Text of the Agreement between Belgium, Denmark, the Federal Republic of Germany, Ireland, Italy, Luxembourg, The Netherlands, the European Atomic Energy Community and the Agency in Connection with the Treaty on the Non-Proliferation of Nuclear Weapons; Texto del Acuerdo Concertado Entre Belgica, Dinamarca, La Republica Federal De Alemania, Irlanda, Italia, Luxemburgo, Los Paises Bajos, La Comunidad Europea De Energia Ato Mica Y El Organismo En Relacion Con El Tratado Sobre La No Proliferacion De Las Armas Nucleares

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1973-09-14

    The text of the Agreement, and of the Protocol thereto, between Belgium, Denmark, the Federal Republic of Germany, Ireland, Italy, Luxembourg, The Netherlands, the European Atomic Energy Community and the Agency in implementation of Article III (1) and (4) of the Treaty on the Non-Proliferation of Nuclear Weapons (reproduced in document INFCIRC/140) is reproduced in this document for the information of all Members [Spanish] Para informacion de todos los Estados Miembros, en el presente documento se transcribe el texto del Acuerdo concertado entre Belgica, Dinamarca, la Republica Federal de Alemania, Irlanda, Italia, Luxemburgo, los Paises Bajos, la Comunidad Europea de Energia Atomica y el Organismo en ejecucion de lo dispuesto en los parrafos 1 y 4 del articulo III del Tratado sobre la no proliferacion de las armas nucleares, asi como el del Protocolo que acompana a dicho Acuerdo.

  3. Cadmium cytotoxicity in albino mice hepatocytes and its possible implications on tropical environments; Citotoxicidad del cadmio en hepatocitos de raton albino y sus posibles implicaciones en ambientes tropicales

    Energy Technology Data Exchange (ETDEWEB)

    Marcano, Letty; Carruyo, Ingrid; Montiel, Xiomara [Univ. del Zulia, Facultad Experimental de Ciencias, Dept. de Biologia (Venezuela); com, letty_marcano@hotmail; Faria, Clarisa de R [Univ. del Zulia, Facultad de Medicina, Catedra de Histologia, Maracaibo, Zulia (Venezuela)

    2006-06-15

    Analyzed phenotypic, structural and ultrastructural alterations induced by Cd{sup +2} in hepatocytes extracted from Swiss Albino mice. Cadmium was given orally in watery solution of CdCl{sub 2} during 100 days at concentrations of 50 ppm, 100 ppm and 150 ppm. In controls, distilled water alone was used. The samples were processed with the paraffin inclusion and hematoxylin-eosin coloration techniques for light microscopy. The conventional technique was used for transmission electron microscopy . Phenotypic (size and weight differences) and physiologic changes (muscular weakness, unrest) were found; at the structural level it was noticed loss of trabecular disposition and of lobular architecture, lymphocyte agglomeration, vacuolisation, dilatation of sinusoid and central vein, among others. The ultrastructural study evidenced alterations coincident with those seen with light microscopy, which were accentuated with the increase of metal concentration: nucleolus with a high number of fibrillar centers (50 ppm); voluminous lipidic drops in the cytoplasm, loose endoplasmic rough reticulum, cytoplasmic vacuolisation, altered lysosomes and peroxisomes (100 ppm); contracted nucleis with condensed chromatin, dilatation of intracellular space and mitochondria, and loss of fibrillar areas (150 ppm). Cadmium produces a toxic effect in the hepatic cells; the effect is more severe at higher concentration, leading to cellular necrosis. (author) [Spanish] Se realizo un analisis de las alteraciones fenotipicas, estructurales y ultraestructurales inducidas por Cd{sup +2} en hepatocitos de raton albino suizo. El Cadmio fue suministrado via oral en solucion acuosa de CdCl{sub 2} durante 100 dias a concentraciones de 50 ppm, 100 ppm y 150 ppm. En los controles la solucion de cadmio fue sustituida por agua destilada. Las muestras fueron procesadas utilizando la tecnica de inclusion en parafina y tenidas con hematoxilina-eosina para microscopia optica y por la tecnica convencional para

  4. Caracterización de un suelo arcilloso tratado con hidróxido de calcio

    OpenAIRE

    Carlos Hernando Higuera Sandoval; Jenny Carolina Gómez Cristancho; Óscar Eduardo Pardo Naranjo

    2013-01-01

    Propone unametodología para el tratamiento de suelos susceptibles (arcillas) mediante la incorporación del hidróxido de calcio como estabilizante, en busca del mejoramiento de sus características físicas, mecánicas y químicas. La caracterización del suelo consistió en la elaboración de una serie de ensayos de laboratorio que determinaran sus características físico-mecánicas y químicas. Además de esto, se diseñaron mezclas de suelo-hidróxido de calcio en las que se varió el porcentaje de aditi...

  5. Análisis del perfil de compuestos volátiles del mango (mangifera indica l. var. tommy atkins) tratado por métodos combinados

    OpenAIRE

    Moreno, Angélica; León, David F.; Giraldo, Germán A.; Ríos, Eunice

    2010-01-01

    Se evaluó el perfil de compuestos volátiles del mango (Mangifera indica L. Var. Tommy Atkins) al ser tratado con la combinación de los métodos de deshidratación osmótica con o sin pulso de vacío (DOPV y DO) y con secado por aire caliente o con vacío (SAC y VAC). El tiempo utilizado en la cinética del proceso de DO fue de 42 horas y la DOPV de 30 horas; en los procesos de secado, el SAC se realizó durante 24 horas y el VAC requirió 40 horas. En el perfil de compuestos volátiles del mango fresc...

  6. ANÁLISIS DEL PERFIL DE COMPUESTOS VOLÁTILES DEL MANGO (Mangifera indica L. Var. Tommy Atkins) TRATADO POR MÉTODOS COMBINADOS

    OpenAIRE

    Angélica Moreno; David F. León; Germán A. Giraldo; Eunice Ríos

    2010-01-01

    Se evaluó el perfil de compuestos volátiles del mango (Mangifera indica L. Var. Tommy Atkins) al ser tratado con la combinación de los métodos de deshidratación osmótica con o sin pulso de vacío (DOPV y DO) y con secado por aire caliente o con vacío (SAC y VAC). El tiempo utilizado en la cinética del proceso de DO fue de 42 horas y la DOPV de 30 horas; en los procesos de secado, el SAC se realizó durante 24 horas y el VAC requirió 40 horas. En el perfil de compuestos volátiles del mango fresc...

  7. IMPACTO DEL TRATADO DE LIBRE COMERCIO ENTRE COLOMBIA Y EEUU, SOBRE EL ACCESO A LOS MEDICAMENTOS EN COLOMBIA

    Directory of Open Access Journals (Sweden)

    José David Millán Cano

    2012-12-01

    Full Text Available Este artículo, más que pretender continuar con la franca crítica al Tratado de Libre Comercio (TLC entre Colombia y EE.UU, busca dar una aproximación a las posibles repercusiones que este acuerdo tendrá sobre el acceso a los medicamentos de los afiliados al Sistema General de Seguridad Social en Salud (SGSSS colombiano en  mediano y largo plazo.Para lograr esto, se definirá qué se entiende por Tratado de Libre Comercio, para luego realizar una breve reseña histórica de su evolución. Luego, y para entender un poco la relación que ha unido a Colombia y a EEUU en términos comerciales, se intentará dar un panorama histórico sobre el tema. Se continuará con una descripción de cómo fue el proceso de negociación sin perder de vista los antecedentes y causas de tipo político, económico, y social que motivaron un TLC entre Colombia y EEUU, teniendo en cuenta qué sectores quedaron incluidos en la negociación, qué servicios y con qué condiciones, para luego, evaluar cómo se ve afectado el derecho a la salud y sobre todo el acceso a los medicamentos para los afiliados al SGSSS colombiano a mediano y largo plazo.

  8. THERAPEUTIC DRUG TRIAL IN ALBINO MICE AGAINST TRYPANOSOMIASIS

    Directory of Open Access Journals (Sweden)

    S. Ahmad, A. A. Nasir and A.H. Awan

    2005-01-01

    Full Text Available This study was conducted to determine the trypanocidal efficacy of Antrycide, Fatrybanil and Trypamedium in albino mice experimentally infected sub-cutaneously with Trypanosoma evansi. For this purpose, 25 albino mice were randomly divided into five equal groups i.e. A, B, C, D and E. Groups A, B and C were infected and then treated with Antrycide, Fatrybanil and Trypamedium, respectively. Group D was kept as infected and group E non-infected control. On the basis of blood smear examination, the efficacy of Antrycide and Fatrybanil was found 100% when used in single dose as compared to Trypamedium which was 100% effective with second dose.

  9. The reproductive dysfunction effects of gasoline inhalation in albino rats.

    Science.gov (United States)

    Ugwoke, C C; Nwobodo, E D; Unekwe, P; Odike, M; Chukwumai, S T; Amilo, G

    2005-01-01

    Daily exposure to fuel vapour may pose significant health risk to exposed individuals. Fifteen each of male and female albino rats weighing between 110-230g were divided into test (10) and control (5) groups each. The test animals; were exposed to inhalation gasoline for one hour daily for twenty-one consecutive days. All animals were then bled and the serum levels of the reproductive hormones determined. The results showed significant [P inhalation gasoline exposure significantly [P < 0.05] lowers the levels of reproductive hormones in albino rats and may thus interfere with reproduction.

  10. Serological Changes Induced by Blend of Sunset Yellow, Metanil Yellow and Tartrazine in Swiss Albino Rat, Rattus Norvegicus

    OpenAIRE

    Saxena, Beenam; Sharma, Shiv

    2014-01-01

    Objective: The present study was carried out to evaluate the toxic effect of blend of some food colors on Swiss albino rats. Materials and Methods: A blend (1:1:1) of sunset yellow, metanil yellow and tartrazine showed additive effects on serological parameters which indicate that addition of these dye together in food stuff may give rise to more toxic effects than are produced by each dye individually. Animals were divided into four groups (I, II, III, and IV). First group was treated as con...

  11. "La pequeña y mediana empresa ante la apertura comercial y el tratado de libre comercio"

    OpenAIRE

    Beltran Cázares, Graciela

    2011-01-01

    En México la pequeña y mediana empresa constituye, hoy en día, el contro del sistema económico del país, debido a que más del 95% de las empresas son pequeñas y medianas. Estas proporcionan más de la mitad de todos los empleos de la nación, incluyendo actividades que no son comerciales, ofrecen el campo experimental en donde se generan con frecuencia nuevos productos, nuevas ideas, nuevas técnicas y nuevas formas de hacer las cosas. México firmó el Diecisiete de Diciembre de 1992 un Tratado d...

  12. Modifications in sperm quality of Wister Albino Rats by Ethanol ...

    African Journals Online (AJOL)

    The effect of a well known herb, Phyllanthus amarus on the sperm characteristics in male albino rats was studied. This was an investigation of the age-long claim by the locales in the rural communities in the southern states of Nigeria where this plant is consumed religiously that it affects sperm quality, hence sexual potency ...

  13. Biological studies on albino rats fed with Sorghum bicolor starch ...

    African Journals Online (AJOL)

    Partially purified amylase was extracted from the culture medium of Rhizopus sp. grown in potato dextrose broth for 48 h at room temperature by precipitation with 96.9% ethanol. The enzyme was used to hydrolyze sorghum starch. The hydrolyzed product was afterwards formulated into rat feed, which was fed to albino rats ...

  14. Malignant Melanoma in an Albino | Efem | Sudan Journal of Medical ...

    African Journals Online (AJOL)

    Oculocutaneous albinism is a rare autosomal recessive disorder characterised by generalised depigmentation, photophobia, decreased visual acuity, and nystagmus. Malignant melanoma is rare in patients with albinism. We report a case of a large advanced fumigating tumour on the right forearm of a male Nigerian albino ...

  15. Narratives of Tanzanian Albinos in Kenya and South-Africa

    African Journals Online (AJOL)

    Nneka Umera-Okeke

    Indexed African Journals Online: www.ajol.info ... Postdoctoral Fellow, School of Social and Government Studies, ... A network of syndicates hunting for albinos, .... tracing of PWA's residences and locations, through friends and later through head teachers and principals in secondary schools, key informants in shopping ...

  16. Cutaneous Cancers in Nigerian Albinos: A Review of 22 Cases

    African Journals Online (AJOL)

    2018-04-20

    Apr 20, 2018 ... Context: Albinism is an inherited disorder of hypopigmentation involving the skin, eyes, and hair. ... These data include age, gender, site of the lesion, the diagnosis, no of lesions excised .... increase awareness to treatment among the albinos and their .... their identity, but anonymity cannot be guaranteed.

  17. Biochemical response of normal albino rats to the addition of ...

    African Journals Online (AJOL)

    Experiments were conducted to determine the biochemical effect of Hibiscus cannabinus and Murraya koenigii extracts on normal albino rats using standard methods. Analyses carried out indicated that the aqueous leaf extract of H. cannabinus and M. koenigii exhibited significant hypolipideamic activity in normal rats.

  18. Immunological evaluation of Aeromonas infection in albino rats | El ...

    African Journals Online (AJOL)

    Aeromonas hydrophila is the most common bacterial species causing an acute self limiting diarrheal illness in mammals. Albino rats were categorized into treated and control groups. Treated groups were injected daily intraperitoneally with 0.2ml of bacterial suspension containing 6x106 cells/ml of 0.9% NaCl, while the ...

  19. the reproductive dysfunction effects of gasoline inhalation in albino

    African Journals Online (AJOL)

    admin

    exposure to inhalation gasoline, which generally saturate the ambient air of their workplaces. In this study, we challenged male and female albino rats with gasoline vapour and monitored the endocrine disruptive effects as part of a comprehensive study of the health risks faced by refinery workers in Nigeria. The ultimate.

  20. Diseño del proceso de obtención de trozos secos de carambola (averroha carambola l.) tratados osmóticamente

    OpenAIRE

    Castillo Ortiz, Maria Eugenia; Cornejo Z., Fabiola

    2009-01-01

    En el presente trabajo se diseñó la línea de proceso para obtener trozos secos de carambola tratados osmóticamente, mostrando la utilidad industrial que posee la carambola para la elaboración de productos que puedan ser exportados al mercado extranjero con excelentes características organolépticas y condiciones de estabilidad en percha óptimas. Los experimentos realizados sirvieron para establecer la cinética de deshidratación osmótica, analizada a 3 concentraciones de sacarosa (40 ºBrix,...

  1. Tratado de libre comercio entre Colombia y los Estados Unidos desde el análisis económico del derecho

    OpenAIRE

    Aldana Carrillo, Diego David

    2015-01-01

    El presente trabajo es una aproximación al Tratado de Libre Comercio entre Colombia y los Estados Unidos desde el Análisis Económico del Derecho. Inicialmente se reconstruye la normativa del acuerdo y sus funciones económicas fundamentales, contextualizando el libre comercio con Estados Unidos desde una perspectiva comparada, y analizando su papel tanto en el ámbito de la economía globalizada como en el ordenamiento jurídico nacional. Posteriormente se realiza una aproximación conceptual al A...

  2. Differences in MITF gene expression and histology between albino and normal sea cucumbers ( Apostichopus japonicus Selenka)

    Science.gov (United States)

    Zhao, Heling; Yang, Hongsheng; Zhao, Huan; Liu, Shilin; Wang, Tianming

    2012-01-01

    Albino Apostichopus japonicus occur both in the wild and in captivity. The offspring of albino A. japonicus also suffer from albinism. The formation of melanin in the melanocytes is dependant on microphthalmia-associated transcription factor (MITF). To investigate the role of MITF in controlling albinism, we cloned the full-length MITF cDNA from A. japonicus and compared MITF mRNA expression in albino and normal A. japonicus. In addition, we used light and electron microscopy to compare histological samples of normal and albino A. japonicus. The body wall of albino adults was characterized by significantly lower levels of MITF expression and lower numbers of epidermal melanocytes, which also contained less melanin. In albino juvenile offspring, MITF expression levels were significantly lower 32 d after fertilization and there were fewer, and less developed, epidermal melanocytes. Thus, we conclude that albino A. japonicus have fewer melanocytes and a reduced ability to synthesize melanin, likely because of lower expression of MITF.

  3. Denervación renal percutánea mediante el uso de catéter con balón en pacientes con hipertensión arterial resistente

    Directory of Open Access Journals (Sweden)

    Isabel C. Marín-Orozco

    2015-11-01

    El objetivo del presente reporte es describir detalladamente dos casos de hipertensión arterial resistente, tratados mediante ablación con radiofrecuencia con el nuevo dispositivo Vessix® de la compañía Boston Scientific.

  4. Therapeutic Efficacy of Ginger, Cisplatin and Radiation on Chemically-Induced Cancer in Male Albino Rats

    International Nuclear Information System (INIS)

    El-Beih, N.M.; Galal, S.M.; Fahmy, N.M.; Abd El-Azime, M.G.

    2015-01-01

    This study aimed to investigate the in vivo effect of dietary supplementation with ginger to evaluate its therapeutic effect against lung and kidney cancer and in combination with cisplatin as chemotherapy and radiotherapy in male albino rats. 54 male albino rats were divided into nine groups of 6 animals each, all animals were allowed to food and water ad libitum . Group I was treated with 0.5 ml saline, orlly for 12 consecutive weeks serve as con - trol group Group II injected with N-nitrosodimethylamine (NDMA) and carbon tetrachloride (CCl 4 ); all groups were injected with NDMA + CCl 4 for 6 weeks. Group III were given ginger for 6 consecutive weeks (200 mg/kg, b.wt./day). Group IV animals received cisplatin, group V irradiated with 2 Gy, group VI treated with ginger then irradiated, group VII treated with ginger then injected with cisplatin, group VIII injected with cisplatin then irradiated and group IX treated with ginger and cisplatin then irradiated. Antioxidant status in both kidney and lung tissues were estimated by determining the activity of antioxidant enzyme superoxide dismutase (SOD); as well as the level of reduced glutathione (GSH), Malondialdehyde (MDA) and Nitric oxide (NO). In parallel to histopathological investigations of lung and kidney tissues. In addition, Tumor Necrosis Factor Alpha (TNF-α) level, advanced oxidative protein product (AOPP), urea, creatinine and uric acid. Remarkable disturbances were observed in the levels of all tested parameters in NDMA + CCl 4 group. On the other hand, rats injected with the cancer agents then treated with cisplatin+radiation showed moderate improvements in the studied parameters while, treatment with ginger + cisplatin + radiation ameliorated the levels of the disturbed bio

  5. Cutaneous Cancers in Nigerian Albinos: A Review of 22 Cases

    Directory of Open Access Journals (Sweden)

    Oluwafemi Olasupo Awe

    2018-01-01

    Full Text Available Context: Albinism is an inherited disorder of hypopigmentation involving the skin, eyes, and hair. This disorder results in the absence or reduction in melanin production. There are two main types of albinism which are ocular albinism and oculocutaneous albinism. It could also be classified as syndromic or nonsyndromic the melanin, which protects from the harmful effect of ultraviolet radiation of the sun on the normal skin, is deficient in the albino, predisposing them more, to cutaneous malignancies. Aim: This study is to highlight the epidemiology of cutaneous cancers in albinos in sub-urban Nigeria. Methodology: This is a retrospective review of all albinos with histological diagnoses of cutaneous malignancies that presented to Irrua Specialist Teaching Hospital, Irrua Edo State, Nigeria between September 2010 and August 2016. The following details were extracted from the patients' case-notes, operation register, and the histopathology register. These data include age, gender, site of the lesion, the diagnosis, no of lesions excised, and duration of the lesion (s. These were collated and analyzed using SPSS version 22. Results: There were 22 albinos with histopathologically diagnosed cutaneous malignancies. There were 11 males and 11 females with male:female of 1. The age range is from 25 to 55 years with the mean of 34.68. Conclusion: Albinism is one of the most common causes of cutaneous malignancies, and majority of them present with locally advanced lesions that will need excision biopsy resulting in disfigurement. This problem can be prevented in many cases with proper community education, support, and free health care. There is also need for them to present early whenever they noticed any skin changes.

  6. Vigabatrin can enhance electroretinographic responses in pigmented and albino rats.

    Science.gov (United States)

    Akula, James D; Noonan, Emily R; Di Nardo, Alessia; Favazza, Tara L; Zhang, Nan; Sahin, Mustafa; Hansen, Ronald M; Fulton, Anne B

    2015-08-01

    To evaluate the effects of the antiepileptic medication vigabatrin (VGB) on the retina of pigmented rats. Scotopic and photopic electroretinograms were recorded from dark- and light-adapted Long-Evans (pigmented) and Sprague Dawley (albino) rats administered, daily, 52-55 injections of 250 mg·kg(-1)·day(-1) VGB or 25-26 injections of 500 mg·kg(-1)·day(-1) VGB, or a corresponding number of sham injections. Sensitivity and saturated amplitude of the rod photoresponse (S, Rm(P3)) and postreceptor response (1/σ, Vm) were derived, as were sensitivity and amplitude of the cone-mediated postreceptor response (1/σ(cone), Vm(cone)). The oscillatory potentials and responses to a series of flickering lights (6.25, 12.5, 25 and 50 Hz) were studied in the time and frequency domains. A subset of rats' eyes was harvested for Western blotting or histology. Of the parameters derived from dark-adapted ERG responses, in both pigmented and albino rats, VGB repeatedly and reliably enhanced electroretinographic parameters; no significant ERG deficits were noted. No significant alterations were observed in ER/oxidative stress or in the Akt cell death/survival pathway. There were migrations of photoreceptor nuclei toward the RPE and outgrowths of bipolar cell dendrites into the outer nuclear layer in VGB-treated rats; these were never observed in sham-treated animals. Although VGB is associated with retinal dysfunction in patients and VGB toxicity has been demonstrated by other laboratories in the albino rat, in our pigmented and albino rats, VGB did not induce deficits in, but rather enhanced, retinal function. Nonetheless, retinal neuronal dysplasia was observed.

  7. Histomorphological effects of isoniazid induced hepatotoxicity in male albino mice

    International Nuclear Information System (INIS)

    Humayun, F.; Zareen, N.

    2017-01-01

    To observe the histomorphological changes of isoniazid induced hepatotoxicity in male albino mice. Methodology: This experimental study was carried out at University of Health Sciences, Lahore, Pakistan from January to December 2013. Forty male albino mice selected by simple random technique, were divided into two groups; A-Control, and B-experimental. Group A comprised of 15, while Group B comprised 25 mice. Both the groups were kept under identical conditions and diet. However, experimental group was treated with an additional oral hepatotoxic dose of isoniazid i.e. 100mg/kg bodyweight daily for 30 days. After 30 days, the animals were sacrificed and livers were dissected out. Gross comparison of the organ and stained sections were histologically compared for morphological differences between the groups. Fischer Exact test was used to analyze the qualitative data and a p<0.05 was considered significant. Results: Group A animals showed the normal liver architecture. Whereas, those of Group B showed deranged hepatic histomorphology. Conclusion: Hepatotoxic dose of Isoniazid caused histomorphological alterations in the liver of male albino mice. (author)

  8. La igualdad de genero en el Tratado Constitucional de la Unión Europea

    Directory of Open Access Journals (Sweden)

    Emanuela Lombardo

    2012-02-01

    Full Text Available El artículo analiza el tratamiento de la igualdad de género en el Tratado Constitucional Europeo de 2004, con especial referencia a la incorporación de una perspectiva de género en el proceso. Evalúa tanto los resultados positivos, relacionados con el mantenimiento del acervo comunitario en materia de igualdad, la inclusión de la Carta de los Derechos Fundamentales de la UE, y las movilizaciones a favor de la igualdad dentro y fuera de la Convención, como los resultados negativos, concernientes a la limitada capacidad de incorporar una perspectiva  de género en el proceso y en el texto constitucional. Ésta se atribuye al concepto estrecho de igualdad de género adoptado en el documento, a las resistencias en incorporar una perspectiva de género en todas las áreas políticas, a la baja representación de las mujeres en la Convención, y a la ausencia de una perspectiva de género en el proceso institucional y administrativo. En la conclusión se avanzan algunas hipótesis explicativas de dichas limitaciones. The article analyses the treatment of gender equality in the 2004 European Constitutional Treaty, with particular reference to the incorporation of a gender perspective in the process. The assessment includes positive results, that are related to the maintenance of the acquis cornrnmunautaire on equality, the inclusion of the Charter of Fundamental Rights, and the mobilisation in favour of equality within and outside the body of the Convention. It also considers the negative results that have to do with the limited capacity to incorporate a gender perspective into the process and the text of the Constitution. This limits are attributed to the narrow concept of gender equality adopted in the document, the resistance to incorporate a gender perspective into all policy areas, the low representation of women in the Convention, and the absence of a gender perspective in the institutional and administrative process. The

  9. Efectos de inhibidores de colinesterasa en pacientes con enfermedad asociada a cuerpos de Lewy

    Directory of Open Access Journals (Sweden)

    Nilton Custodio

    2008-09-01

    Full Text Available Objetivos: Analizar los efectos de los inhibidores de colinesterasas (ICE donepezilo, rivastigmina y galantamina en el tratamiento de demencia con cuerpos de Lewy (DCL y demencia de la enfermedad de Parkinson (DEP. Diseño: Estudio tipo ensayo abierto. Lugar: Servicio de Neurología, Hospital Militar Central (HMC, y Unidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia, Clínica Internacional. Participantes: Pacientes con demencia asociada a cuerpos de Lewy y demencia de la enfermedad de Parkinson. Intervenciones: Las mediciones de eficacia en 33 pacientes con diagnóstico de DCL y DEP se realizó con el Mini-Mental State Examination (MMSE, Alzheimer Disease Assessment Scale cognitive subscale (ADAS-cog, Alzheimer’s Disease Cooperative Study-Clinical Global Impression of Change (ADCS-CGIC, Alzheimer’s Disease Cooperative Study-Activities of Daily Living Inventory (ADCS-ADL, Neuro-Psychiatry Inventory (NPI, Prueba de dibujo de Reloj de Manos (PDR-M y la Unified Parkinson´s Disease Rating Scale-motor subscale (UPDRS-part III. Principales medidas de resultados: Síntomas cognitivos, funcionamiento global y actividades de vida diaria de los pacientes. Resultados: Diecisiete pacientes fueron tratados con rivastigmina, 9 con galantamina y 7 con donepezilo. Luego de 6 meses de tratamiento, los pacientes en tratamiento con rivastigmina mejoraron en 1,39 puntos en ADAS-cog respecto de su medición basal, mientras que los pacientes tratados con donepezilo y galantamina no mostraron cambios (cambios <0,2 puntos. Respecto al ADCS-ADL, los pacientes tratados con rivastigmina, donepezilo y galantamina demostraron disminución de 0,42, 0,58 y 0,75 puntos, respectivamente. En el MMSE, los pacientes tratados con rivastigmina y donepezilo no mostraron cambios y los pacientes tratados con galantamina tuvieron una disminución promedio de 1,19 puntos. No hubo diferencias significativas en la incidencia de síntomas parkinsonianos en los tres

  10. Comparison of symptoms, physical examination and electromyography findings, with the results of surgery of carpal tunnel release, in patients treated between January 2007 and December 2008, at the Hospital Calderon Guardia; Comparacion de la sintomatologia, exploracion fisica y hallazgos electromiograficos, con los resultados de la cirugia de liberacion de tunel carpal, en pacientes tratados entre enero 2007 y diciembre 2008, en el Hospital Calderon Guardia

    Energy Technology Data Exchange (ETDEWEB)

    Chavarria Alvarado, Manuel

    2010-07-01

    A comparison of the preoperative findings was performed in patients with the diagnosis of carpal tunnel syndrome, with functional outcomes and postoperative residual pain, using the scale Patient Rate Wrist Evaluation (PRWE). All patients have had clinical history, physical examination and electromyography studies. They were operated by minimally invasive open surgery. The information was collected in an Excel table and patients have located via telephone. 100% of the evaluated patients have engaged in activities that involve trauma or repetitive wrist movements. The physical sign with predicative positive value for suspect of carpal tunnel syndrome has been the Phalen, present in over 70% of cases. The amount of physical signs present preoperatively and postoperative results were found without correlation. The mixed lesion, both sensory and motor has been the most found in electrodiagnostic studies. Patients whose studies have been negative, postoperative results have showed less favorable. Only 69% of patients operated in the orthopedic service of the Hospital Rafael Angel Calderon Guardia (HCG), have had favorable postoperative results. (author) [Spanish] Una comparacion de los hallazgos preoperatorios fue realizada en los pacientes con diagnostico del sindrome del tunel carpal, con los resultados funcionales y dolor residual en el posoperatorio, utilizando la escala Patient Rate Wrist Evaluation (PRWE). Todos los pacientes han tenido historia clinica, examen fisico y estudios electromiograficos. Ellos fueron intervenidos mediante cirugia abierta minimamente invasiva. La informacion fue recolectada en una tabla de excel y los pacientes fueron localizados via telefonica. El 100% de los pacientes evaluados se han dedicado a realizar actividades que implican trauma o movimientos repetitivos de las munecas. El signo fisico con valor predictivo positivo para la sospecha de sindrome de tunel carpal ha sido el Phalen, presente en mas del 70% de los casos. La cantidad

  11. Linfoma hepático primario: Evolución favorable con quimioterapia combinada con rituximab Primary hepatic lymphoma: favorable outcome with chemotherapy plus rituximab

    Directory of Open Access Journals (Sweden)

    I. Serrano-Navarro

    2008-11-01

    Full Text Available Comunicamos el caso de una paciente con un linfoma hepático primario tratado con éxito con quimioterapia combinada con rituximab. Utilizando los "encabezamientos estándar para búsquedas bibliográficas informatizadas" (Medical Subject Heading revisamos los casos publicados hasta la fecha de esta infrecuente entidad.This article describes the case of a patient with a non-Hodgkin primary hepatic lymphoma who was successfully treated with chemotherapy combined with rituximab. Using the Medical Subject Headings the published reports of this rare entity were reviewed.

  12. Cicatrização de feridas: estudo comparativo em ratos hipertensos não tratados e tratados com inibidor da enzima conversora da angiotensina

    Directory of Open Access Journals (Sweden)

    Maria de Lourdes Pessole Biondo-Simões

    Full Text Available OBJETIVO: Reconhecer a interferência do captopril na cicatrização de feridas cutâneas de ratos hipertensos. MÉTODOS: Distribuíram-se 111 ratos em quatro grupos: controle normotenso (N=30; controle hipertenso (N=30, os quais receberam 1 ml/dia de solução de cloreto de sódio a 0.9% por via oral; grupo experimento (N=31, hipertensos que receberam 7,5mg/kg/dia de captopril e um grupo aferição (N=20, 10 hipertensos e 10 normotensos, nos quais aferiu-se a pressão na aorta abdominal, no último dia de experimento. Após 15 dias de medicação, fez-se uma incisão da pele e da tela subcutânea, na região médio-dorsal dos grupos I, II e III, seguida de síntese. Ressecaram-se as cicatrizes de 10 animais de cada grupo, no 4.º, 7.º e 14.º dias após a operação, que divididas em duas partes foram enviadas para a tensiometria e para análise histológica. RESULTADOS: A pressão arterial média de 83,18 ± 7,51 mmHg nos normotensos e 151,36 ± 10,51 mmHg nos hipertensos. As cicatrizes dos hipertensos tratados e não tratados eram menos resistentes que as dos normotensos, nos tempos iniciais (p<0,05 e que ao 14.º dia as resistências se igualaram. Não houve diferença entre o grupo tratado e o não tratado. A densidade de colágeno total foi maior nos normotensos em todos os tempos (p<0,05 e não houve diferença entre hipertensos tratados e não tratados. A epitelização, a reação inflamatória e a formação do tecido de granulação foi semelhante nos três grupos. CONCLUSÕES: O captopril, em ratos, não modifica a cicatrização, ficando as diferenças relacionadas à hipertensão.

  13. Possible hepatotoxic consequence of nevirapine use in juvenile albino rats

    Directory of Open Access Journals (Sweden)

    Elias Adikwu

    2017-08-01

    Full Text Available Context: Nevirapine (NVP is used in human immunodeficiency virus exposed neonates. This could present safety concern due to decreased liver metabolizing enzymes activity and renal clearance in neonates. Aims: To determine the hepatotoxic effect of NVP in juvenile albino rats. Methods: Juvenile albino rats were weighed, divided into groups and treated orally with 4-32 mg/kg/day of NVP for 14 days including a recovery group. The control groups were treated with water (placebo and normal saline (solvent. At the end of NVP treatment, rats were weighed and sacrificed, blood was collected and serum extracted. Serum was analyzed for alanine aminotransferase (ALT, aspartate aminotransferase (AST, alkaline phosphatase (ALP, total bilirubin (TB and conjugated bilirubin (CB. The liver was harvested via dissection, weighed and evaluated for AST, ALT, ALP, superoxide dismutase (SOD, catalase (CAT, glutathione (GSH, malondialdehyde (MDA levels and histological damage. Results: The body, absolute and relative liver weights of rats in NVP treated groups were not significantly different (p>0.05 when compared to placebo. However, serum levels of AST, ALT, ALP, TB and CB were significantly increased (p<0.05 in a dose-dependent manner in NVP-treated groups. Furthermore, liver levels of ALT, ALP, AST and MDA were significantly increased (p<0.05 while SOD, CAT, and GSH were decreased in a dose dependent manner in NVP-treated groups. NVP-treated rats were characterized by varying degrees of hepatic morphological alterations. However, in the recovery group, the effects of NVP were reversed. Conclusions: This study observed dose-dependent and reversible hepatotoxicity in nevirapine- treated juvenile albino rats.

  14. Los tratados de arquitectura en los fondos de la Biblioteca Histórica de la Universidad Complutense: una aproximación al estudio de sus procedencias y antiguos poseedores.

    Directory of Open Access Journals (Sweden)

    Lizarraga Echaide, Juan Manuel

    2009-07-01

    Full Text Available La Biblioteca Histórica de la Universidad Complutense de Madrid atesora una importantísima colección de tratados de arquitectura El objeto de este artículo es reconstruir la historia de esta singular colección de libros antiguos de gran riqueza y valor y recuperar la procedencia estos tratados tanto con respecto a las bibliotecas de las instituciones docentes que forman parte de la historia de la Universidad como a las importantes bibliotecas personales que se han ido incorporando a su patrimonio bibliográfico. El conocimiento de las antiguas procedencias constituye una información valiosa que permite nuevas oportunidades de investigación histórica y bibliográfica

  15. Treaty on the Non-Proliferation of Nuclear Weapons. Notification of the Entry into Force; Tratado Sobre la no Proliferacion de las Armas Nucleares. Notificacion de la Entrada en Vigor

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1970-04-22

    By letters addressed to the Director General on 5, 6 and 20 March 1970 respectively, the Governments of the United Kingdom of Great Britain and Northern Ireland, the United States of America and the Union of Soviet Socialist Republics, which are designated as the Depository Governments in Article IX. 2 of the Treaty on the Non-Proliferation of Nuclear Weapons, informed the Agency that the Treaty had entered into force on 5 March 1970 [Spanish] En sus cartas dirigidas al Director General con fecha 5, 6 y 20 de marzo de 1970, respectivamente, el Reino Unido de Gran Bretana e Irlanda del Norte, los Estados Unidos de America y la Union de Republicas Socialistas Sovieticas, designados Gobiernos depositarios en el parrafo 2 del Articulo IX del Tratado sobre la no proliferacion de las armas nucleares, han comunicado al Organismo que dicho Tratado entro en vigor el 5 de marzo de 1970.

  16. Hepatopancreatic intoxication of lambda cyhalothrin insecticide on albino rats

    OpenAIRE

    Elhalwagy, Manal EA; Abd-Alrahman, Sherif H; Nahas, AA; Ziada, Reem M; Mohamady, Aziza H

    2015-01-01

    Background: Despite the known adverse effects of lambda cyhalothrin insecticide, little is known about its hepatopancreatic intoxication effects. The present study was carried out to elucidate sub-chronic effect of Karat 2.5% EC formulation of lambda cyhalothrin on male albino rats. Methods: To explore the effects of exposure to lambda cyhalothrin on rats and its mechanism, low (1/40 of LD50, 5 mg/kg/day) and high dose (1/4 of LD50, 50 mg/kg/day) lambda cyhalothrin were applied to rats via dr...

  17. CULTIVO DE MILHO COM ESGOTO DOMÉSTICO TRATADO

    Directory of Open Access Journals (Sweden)

    Amistander José dos Santos

    2015-01-01

    Full Text Available A crescente demanda por água para abastecimento vem gerando por consequênciaum aumento no volume de água residuária, que requer cuidados especiais para suadisposição final. Nesse sentido esse trabalho se propõe estudar a destinação da água deesgoto doméstico tratado para uso agrícola, tendo como objetivo avaliar os efeitos daaplicação de água residuária provenientes da lagoa aerada e lagoa de maturação, de estaçãode tratamento de esgoto sanitário sobre o sistema solo-planta, produtividade agrícola eoutras características agronômicas da cultura do milho. O experimento foi conduzido emestufa agrícola, utilizando os seguintes tratamentos: T0- água da chuva sem adubação(APS; T1- água chuva + adubação recomendada pela análise de solo (APA; T2 - águaresiduária, sem adubação coletado na saída da lagoa de maturação (ARF e T3 - águaresiduária, sem adubação coletada na saída da lagoa aerada (ARE. Foram feitas análise daágua de turbidez, da condutividade elétrica (CE, dos sólidos totais, do pH, do ortofosfatosolúvel, do Nitrogênio amoniacal ( NH4+, Ca2+ e Mg2+, Na+, da alcalinidade, da Razão deAdsorção de Sódio e DBO. Analisou-se ainda a fertilidade do solo e as variáveisrelacionadas à cultura como altura média da planta, matéria seca, teores de macronutrientese micronutrientes do tecido foliar. De modo geral, o uso de água residuária melhorou afertilidade do solo, sendo mais eficiente que o uso de água de chuva + adubaçãoconvencional para elevar o pH do solo e em diminuir os teores de Al3+ trocável e de H+Ale tão eficiente quanto para elevar a soma de bases (SB, a capacidade de troca catiônicaefetiva (CTC e saturação por bases (V. Entretanto nas condições desse ensaio, foi possívelconcluir que no presente estudo, evidenciaram-se limitações da utilização de águasprovenientes da lagoa facultativa na irrigação do milho (Zea mays L. em relação ao Na+ nosolo e a RAS, devendo ser

  18. Las indicaciones geográficas en el TLC firmado por Colombia y Perú con EUA frente al TLC con Chile.

    Directory of Open Access Journals (Sweden)

    Juan Andrés Zarama Medina

    2007-06-01

    Full Text Available El propósito de este trabajo es hacer un análisis crítico del tratamiento que se ha dado a las Indicaciones Geográficas y mas específicamente a las Denominaciones de Origen en el Tratado de Libre Comercio que firmaron recientemente por Colombia y Perú, con los Estados Unidos (TLC, al que en adelante denominaremos TLC CAN, y compararlo con el TLC firmado con Chile (En adelante TLC CHILE. Para efectos de este trabajo, centraremos nuestra atención de manera específica en la tendencia de estos tratados a tratar las indicaciones geográficas y en especial las denominaciones de origen, como marcas colectivas y de certificación o garantía.

  19.  Miners’ magic: artisanal mining, the albino fetish and murder in Tanzania

    DEFF Research Database (Denmark)

    Bryceson, Deborah; Jønsson, Jesper Bosse; Sherrington, Richard

    2010-01-01

    purchase the albino charms, the waganga healers renowned for their healing, divination and sorcery skills who prescribe and sell the charms, and the albino murder victims. The agrarian background, miners’ ambitions and a clash of values comprise our starting point for understanding the victimisation...

  20. EVOLUCIÓN DE LA PROPIEDAD INTELECTUAL EN LOS TRATADOS DE LIBRE COMERCIO SUSCRITOS POR CANADÁ.

    OpenAIRE

    Vaccaro, Christian Schmitz

    2015-01-01

    O esforço para integrar-se economicamente se enquadra em uma ampla tendência de globalização, especialmente econômica e comercial, que impera em nosso mundo há algum tempo. Isso leva ao cumprimento de altas exigências para poder competir nos mercados mundiais. O Canadá tem assinado múltiplos tratados de livre comércio com várias nações. Para os fins do presente trabalho, centrar-nos-emos particularmente na relação entre propriedade intelectual e tratados de livre comércio, examinando as dispo...

  1. El lugar de la sátira en la poética: los tratados españoles del siglo XIX

    Directory of Open Access Journals (Sweden)

    González Alcázar, Felipe

    2008-12-01

    Full Text Available This article aims to analyse the satirical genre and its connections with Poetics in the Spanish Poetry and Rhetoric precept treatises of the nineteenth century. Throughout that century, literary theory was subject to major changes, such as the success of Hegel’s postulates on literary genres. Satire faces these changes and its own evolution: it was first identified with the Roman satura and afterwards through its various forms, it became a mixed or transitional genre. Its fragile nature seems to confront directly the normative perpetuity of treatises that, in spite of their rupture with romanticism, may be considered inheritors of the classicist principles.Se propone en este artículo investigar el género satírico y sus relaciones con la Poética a través de los tratados poético-retóricos de preceptiva españoles del siglo XIX. A lo largo de toda esa centuria la teoría literaria estuvo sujeta a grandes transformaciones, entre ellas, el triunfo de los principios hegelianos acerca de los géneros literarios. La sátira se enfrenta a esas mismas transformaciones y a su propia evolución: primero, identificada con la satura romana, y luego, a través de sus numerosas formas, convertida en un género mixto o de transición. Su lábil naturaleza parece enfrentarse directamente con la perennidad normativa de los tratados que, a pesar de la ruptura romántica, pueden considerarse herederos de los principios clasicistas.

  2. Effect of acetylsalicylic acid on spermatogenesis in adult albino mice

    International Nuclear Information System (INIS)

    Ameer, M.K.; Tahrir, M.

    2015-01-01

    Spermatogenesis in male albino mice. Study Design: Laboratory based randomized controlled trial. Place and Duration of Study: Department of Anatomy University of Health Sciences, Lahore from Apr, 2012 to Dec, 2012. Material and Methods: Thirty nine male albino mice, 6-8 weeks old weighing 30 - 5 gm, were used; these were randomly divided into three groups having thirteen mice in each using random numbers table. Group A served as a control and was given distilled water orally via oral gavage 10 ml per kg for 30 days. Group B was given acetylsalicylic acid 100 mg/kg dissolved in 10 ml distilled orally for a period of 30 days. Group C was given acetylsalicylic acid 25 mg/kg dissolved in 2.5 ml distilled orally for a period of 30 days. Animals were sacrificed 24 hours after the last dose and the testes were removed, fixed in Bouin's fixative for 48 hours. Five microns thick sections of processed tissue were stained with H and E and PAS for calculation of Johnsen score and diameter of seminiferous tubules. Serum testosterone level was measured by testosterone enzyme immunoassay test kits. Results: Microscopic examination demonstrated that ASA treatment lead to statistically significant increase in the mean Johnsen score and mean diameter of seminiferous tubules. Conclusion: It was concluded from the current study that ASA treatment enhances spermatogenesis. (author)

  3. Food Color Induced Hepatotoxicity in Swiss Albino Rats, Rattus norvegicus.

    Science.gov (United States)

    Saxena, Beenam; Sharma, Shiv

    2015-01-01

    Certain dietary constituents can induce toxicity and play a critical role in the development of several hepatic disorders. Tartrazine, metanil yellow and sunset yellow are widely used azo dyes in food products, so the present study is aimed to investigate the food color induced hepatotoxicity in Swiss albino rats. Swiss albino rats were divided into four groups, each group having six animals. Group I served as control, Group II, Group III and Group IV were administered with 25, 50 and 75 mg/kg body weight blend of sunset yellow, metanil yellow and tartrazine for 30 days. Hepatotoxicity in rats treated with a blend of these food colors was studied by assessing parameters such as serum total protein, serum albumin, serum alkaline phosphatase (ALP) as well as hepatic malondialdehyde (MDA). The activity of superoxide dismutase (SOD), reduced glutathione (GSH) and catalase (CAT) were assessed. Significantly increased concentrations of serum total protein, serum albumin, serum ALP and hepatic MDA and significantly lowered levels of SOD, reduced GSH and CAT in the liver tissue of treated animals were observed when compared with control animals. The alteration in the liver includes necrosis of hepatocytes, infiltration and vacuolation. The result indicates that consumption of food color in diet induces liver tissue damage. The used doses of food color were mostly attributable to hepatocellular damage and drastic alteration in antioxidant defense system.

  4. Antidiarrheal Activity of Three Medicinal Plants in Swiss Albino Mice

    Directory of Open Access Journals (Sweden)

    MD. Ashrafuzzaman

    2016-09-01

    Full Text Available Background: Different parts of Allamanda neriifolia (AN, Crinum latifolium (CL, and Bruguiera cylindrical (BC are used in folk medicine to treat diarrhea. Therefore, the aim of this study was to investigate and compare possible antidiarrheal activity of methanol extracts from barks, stems, and roots of AL, CL, and BC in Swiss albino mice. Methods: Antidiarrheal activities of extracts were evaluated at three doses (100mg/kg, 200 mg/kg and 400mg/kg and compared with Loperamide in a castor oil-induced diarrhea and charcoal meal test model in the Swiss albino mice. Results: The aqueous extract of CL and BC administered at doses of 100, 200 and 400mg/kg showed 0%, 24.5%, 62.26% and 5.66%, 37.11%, and 62.26% diarrhea inhibition, respectively (Table 2. This reduction in diarrheal episodes is significant, and maximum effect was observed at the dose of 400mg/kg similarly in the alcohol extracts of both CL and BC. AN administered at the dose of 100, 200 and 400mg/kg showed 55.97%, 74.84% and 74.84% diarrhea inhibition, respectively. Conclusion: The antidiarrheal effect of the AN extract, in contrast to CL and BC, against the castor oil-induced diarrhea model prove its efficacy in an extensive range of diarrheal conditions.

  5. Melanoma maligno em búfalos (Bubalus bubalis albinos

    Directory of Open Access Journals (Sweden)

    Maria Cecília Florisbal Damé

    2015-10-01

    Full Text Available Descrevem-se melanomas múltiplos em dois búfalos albinos da raça Murrah no Sul do Brasil. Macroscopicamente havia múltiplos tumores enegrecidos no músculo esquelético, pulmões, linfonodos, saco pericárdio, cápsula renal, mediastino e pleura. Microscopicamente foram observadas células epitelióides poliédricas dispostas em ninhos sólidos ou fascículos entrelaçados sustentadas por um estroma colagenoso fino e esparso. O citoplasma era eosinofílico e por vezes continham quantidades variáveis de pigmento de melanina. A taxa de mitose foi baixa. Na imuno-histoquímica houve imunomarcação positiva utilizando anticorpo anti-tirosinase, anti-Melan-A, anti-vimentina, anti-proteína S-100 e antineurofilamento. É possível que o polimorfismo relacionado com o gene da pigmentação em búfalos albinos tenha contribuído para o maior risco de desenvolvimento de melanomas, como foi sugerido em humanos.

  6. Food Color Induced Hepatotoxicity in Swiss Albino Rats, Rattus norvegicus

    Science.gov (United States)

    Saxena, Beenam; Sharma, Shiv

    2015-01-01

    Objective: Certain dietary constituents can induce toxicity and play a critical role in the development of several hepatic disorders. Tartrazine, metanil yellow and sunset yellow are widely used azo dyes in food products, so the present study is aimed to investigate the food color induced hepatotoxicity in Swiss albino rats. Materials and Methods: Swiss albino rats were divided into four groups, each group having six animals. Group I served as control, Group II, Group III and Group IV were administered with 25, 50 and 75 mg/kg body weight blend of sunset yellow, metanil yellow and tartrazine for 30 days. Hepatotoxicity in rats treated with a blend of these food colors was studied by assessing parameters such as serum total protein, serum albumin, serum alkaline phosphatase (ALP) as well as hepatic malondialdehyde (MDA). The activity of superoxide dismutase (SOD), reduced glutathione (GSH) and catalase (CAT) were assessed. Results: Significantly increased concentrations of serum total protein, serum albumin, serum ALP and hepatic MDA and significantly lowered levels of SOD, reduced GSH and CAT in the liver tissue of treated animals were observed when compared with control animals. The alteration in the liver includes necrosis of hepatocytes, infiltration and vacuolation. Conclusion: The result indicates that consumption of food color in diet induces liver tissue damage. The used doses of food color were mostly attributable to hepatocellular damage and drastic alteration in antioxidant defense system. PMID:26862277

  7. Citotoxicidad del cadmio en hepatocitos de ratón albino y sus posibles implicaciones en ambientes tropicales

    OpenAIRE

    Letty Marcano; Clarisa de R. Faría; Ingrid Carruyo; Xiomara Montiel

    2006-01-01

    Se realizó un análisis de las alteraciones fenotípicas, estructurales y ultraestructurales inducidas por Cd+2 en hepatocitos de ratón albino suizo. El metal fue suministrado vía oral en solución acuosa de CdCl2 durante 100 días a concentraciones de 50 ppm, 100 ppm y 150 ppm, en los controles la solución de cadmio fue sustituida por agua destilada. Las muestras fueron procesadas utilizando la técnica de inclusión en parafina y teñidas con hematoxilina- eosina para microscopía óptica y por la t...

  8. Las indicaciones geográficas en el TLC firmado por Colombia y Perú con EUA frente al TLC con Chile.

    OpenAIRE

    Zarama Medina, Juan Andrés

    2007-01-01

    El propósito de este trabajo es hacer un análisis crítico del tratamiento que se ha dado a las Indicaciones Geográficas y mas específicamente a las Denominaciones de Origen en el Tratado de Libre Comercio que firmaron recientemente por Colombia y Perú, con los Estados Unidos (TLC), al que en adelante denominaremos TLC CAN, y compararlo con el TLC firmado con Chile (En adelante TLC CHILE). Para efectos de este trabajo, centraremos nuestra atención de manera específica en la tendencia de estos ...

  9. Diferencias conductuales y cognitivas en dos grupos de escolares con TDAH intervenidos con Arteterapia -vsMetilfenidato y un grupo control

    OpenAIRE

    M. Aurora G. Gallardo Saavedra; Ana Lucía Padrón García; M. del Consuelo Martínez-Wbaldo

    2018-01-01

    Introducción: El trastorno de défcit de atención e hiperactividad TDAH es una entidad neuropsiquiátrica, con prevalencia en la infancia entre 2% y 20%, su tratamiento actual asocia medicamentos y psicoterapia. El arteterapia en salud mental ha sido utilizado para tratar de cambiar el comportamiento y potenciar la cognición. Objetivo: comparar los cambios cognitivo-conductuales en escolares con TDAH tratados con arteterapia-vs-metilfenidato y un grupo control. Método: Ensayo clínico aleatoriza...

  10. Histopathological effects of doxorubicin on pancreas in male albino rats

    Directory of Open Access Journals (Sweden)

    I.A. Ali

    2015-06-01

    Full Text Available The aim of this study was to investigate the histopathological side effects of doxorubicin on pancreas tissue in male albino rats Rattus norvegicus. This study were used 55 adult rats (2.5-3.5 month of age. The rats divided into two groups, the first group include (35 rats. The second group were (20 rats. Microscopial examination of pancreas lesion demonstrated oedema around the acini, swelling of the epithelial cells of acini, occurance of cystic fibrosis (mucoviscidosis at the concentration of (4,5 mg/kg of body weight ,occurrence of small islets that form of few cells and exocrine-endocrine transformation. There were thickness in the walls of blood vessels, thrombus, congestion of blood vessels, we conclude, that doxorubicin had histopathological effect on pancreas in sub-acute doses more than chronic doses.

  11. Origins of albino and hooded rats: implications from molecular genetic analysis across modern laboratory rat strains.

    Directory of Open Access Journals (Sweden)

    Takashi Kuramoto

    Full Text Available Albino and hooded (or piebald rats are one of the most frequently used laboratory animals for the past 150 years. Despite this fact, the origin of the albino mutation as well as the genetic basis of the hooded phenotype remained unclear. Recently, the albino mutation has been identified as the Arg299His missense mutation in the Tyrosinase gene and the hooded (H locus has been mapped to the ∼460-kb region in which only the Kit gene exists. Here, we surveyed 172 laboratory rat strains for the albino mutation and the hooded (h mutation that we identified by positional cloning approach to investigate possible genetic roots and relationships of albino and hooded rats. All of 117 existing laboratory albino rats shared the same albino missense mutation, indicating they had only one single ancestor. Genetic fine mapping followed by de novo sequencing of BAC inserts covering the H locus revealed that an endogenous retrovirus (ERV element was inserted into the first intron of the Kit gene where the hooded allele maps. A solitary long terminal repeat (LTR was found at the same position to the ERV insertion in another allele of the H locus, which causes the so called Irish (h(i phenotype. The ERV and the solitary LTR insertions were completely associated with the hooded and Irish coat patterns, respectively, across all colored rat strains examined. Interestingly, all 117 albino rat strains shared the ERV insertion without any exception, which strongly suggests that the albino mutation had originally occurred in hooded rats.

  12. Técnica dramática y retórica de las pasiones en el Tratado completo del arte del canto de Manuel García

    Directory of Open Access Journals (Sweden)

    Díaz Marroquín, Lucía

    2007-12-01

    Full Text Available The history of European singing technique, from the Italian origins of the stile rappresentativo and the early Seicento musical drama to the heights of bel canto, seems inextricably related to the classical rhetorical and philosophical theories, later re-interpreted by the humanist and rationalist authors. Manuel García’s Tratado completo del arte del canto inherits this tradition and contributes to it with every single observation or musical example included in this eminently practical work.

    Desde los orígenes italianos del stile rappresentativo y del drama musical, en los últimos años del siglo XVI y primeros del XVII, hasta el esplendor del bel canto, la historia de los tratados de canto europeos se encuentra inseparablemente asociada a las teorías retóricas y filosóficas clásicas, más tarde reinterpretadas por los autores humanistas y preenciclopedistas. Al escribir su Tratado completo del arte del canto, una obra eminentemente práctica, Manuel García hereda esta tradición y contribuye a ella con cada una de las observaciones y ejemplos musicales que propone.

  13. Solución de controversias en los tratados bilaterales de inversión: mapa de situación en América del Sur

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    Magdalena Bas Vilizzio

    2015-03-01

    Full Text Available Este trabajo analiza las características particulares del sistema legal internacional de solución de controversias inversor-Estado, con especial foco en los tratados bilaterales de inversión (TBI en vigor en América del Sur, salvo excepciones. En este marco, aplicando la teoría de los regímenes internacionales (Krasner, 1983, se examinan las tres posiciones de los Estados de la región en torno al tema: 1 no ratificar TBI ni ser miembro del Centro Internacional de Arreglo de Diferencias relativas a Inversiones (CIADI (Brasil; 2 denunciar los TBI en vigor y abandonar el CIADI (Bolivia, Ecuador y Venezuela; 3 mantener los TBI en vigor y permanecer en los foros de solución de controversias actuales (Argentina, Chile, Colombia, Guyana, Paraguay, Perú, Surinam y Uruguay.

  14. The 'evil albino' stereotype: an impediment to the right to equality.

    Science.gov (United States)

    Mswela, Maureen

    2013-03-01

    This article address the 'evil albino' plot device or albino bias as portrayed in films and explores how such labelling stimulates societal intolerance and discrimination against People Living With Albinism. The article reveals how media perpetuates stereotypes of albinism through their portrayal of role players and argues that the continued existence of such stereotypes is a failure to see albinism for what it is: a medical condition. The article further discusses Albinism related stigma and discrimination against the backdrop of the 'evil albino' plot device.

  15. ANÁLISIS DEL PERFIL DE COMPUESTOS VOLÁTILES DEL MANGO (Mangifera indica L. Var. Tommy Atkins TRATADO POR MÉTODOS COMBINADOS

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    Angélica Moreno

    2010-09-01

    Full Text Available Se evaluó el perfil de compuestos volátiles del mango (Mangifera indica L. Var. Tommy Atkins al ser tratado con la combinación de los métodos de deshidratación osmótica con o sin pulso de vacío (DOPV y DO y con secado por aire caliente o con vacío (SAC y VAC. El tiempo utilizado en la cinética del proceso de DO fue de 42 horas y la DOPV de 30 horas; en los procesos de secado, el SAC se realizó durante 24 horas y el VAC requirió 40 horas. En el perfil de compuestos volátiles del mango fresco analizado por cromatografía de gases acoplada a detector de espectrometría de masas (GC-MS se encontraron compuestos tipo mono y sesquiterpénico, además de ácidos y ésteres grasos. El germacreno D (20,49% fue el compuesto terpénico de mayor abundancia encontrado en el análisis realizado. La cantidad de compuestos volátiles en la fruta procesada fue afectada por la aplicación de DOPV y VAC; sin embargo estas pérdidas fueron menores que en las muestras secadas sin pretratamiento osmótico. En el análisis sensorial realizado, las frutas tratadas con DOPV y DO presentaron una menor intensidad calificada en el olor en comparación con la muestra no pretratada.

  16. Eficacia del tratamiento acupuntural en pacientes con epicondilitis humeral externa

    Directory of Open Access Journals (Sweden)

    Ida Pantoja Fornés

    2015-07-01

    Full Text Available Se realizó una intervención terapéutica en 100 pacientes de 20-59 años, con epicondilitis humeral externa, atendidos en la Sala de Rehabilitación del Policlínico Comunitario Docente “Eduardo Mesa Llull”, del municipio de II Frente, de la provincia Santiago de Cuba, desde septiembre de 2013 hasta marzo de 2014, para evaluar la eficacia del tratamiento acupuntural en ellos. La muestra fue dividida en 2 grupos de 50 integrantes cada uno, seleccionados de forma aleatoria. Los del grupo de estudio fueron tratados con acupuntura más corriente Trabert y los del control con corriente Trabert solamente. Como principales resultados predominaron: el grupo etario de 40-49 años (64,0 %, el sexo femenino (66,0 % y los obreros de servicio (56,0 %. Se obtuvo que los tratados con acupuntura tuvieron una mejor evolución, de donde se infiere que la terapia empleada resultó efectiva para aliviar el dolor en quienes se aplicó

  17. LA RELACIÓN ENTRE TRATADOS DE INVERSIÓN Y CONVENIOS DE DOBLE TRIBUTACIÓN: el caso chileno

    OpenAIRE

    Lazo, Rodrigo Polanco; Villanueva, Felipe Yáñez

    2016-01-01

    El presente artículo examina las relaciones entre los tratados de inversión y los tratados de doble tributación, considerando que, en la actual evolución de ambos tipos de acuerdos, sus disposiciones pueden presentar superposiciones en aspectos tales como estándares de protección, transparencia, trato nacional, cláusula de la nación más favorecida, expropiación y transferencias de capital. Tomando el ejemplo de los tratados suscritos por Chile, en este trabajo se examinan las consecuencias de...

  18. Capsaicin induced histological and ultrastructural changes in the submandibular salivary gland of albino rats

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    Ahmed Mahmoud Halawa

    2016-06-01

    From the present work, it could be concluded that chronic capsaicin intake was associated with noticeable histological and ultrastructural changes in acini, granular convoluted tubules and excretory ducts of the SMSG in albino rats.

  19. Heredity, physiology and malt quality analysis of albino-lemma barley

    International Nuclear Information System (INIS)

    Jin Ting; Wu Kuanran; Yang Jianming; Jia Qiaojun; Wang Junmei; Hua Wei; Chen He; Qiao Hailong

    2013-01-01

    The barley 0601 is a spontaneous albino-lemma mutant from beer barley cultivar Supi3. Genetic control of albino-lemma trait in the mutant 0601 and, the agronomic traits (thousand kernel weight, kernel plumpness), physiological traits (chlorophyll content, proanthocyanidin content) and major malt qualities (diastatic power, malt extract, Kolbach index) were investigated. The results showed that the albino-lemma trait is controlled by one recessive gene, and there were significant differences between the mutant and its wild-type in thousand kernel weight, kernel plumpness, chlorophyll content, diastatic power, and the malt extract, whereas no significant difference in proanthocyanidin content was found. These results provide the basis on mapping and cloning the albino-lemma gene and also provide good material for genetic research. (authors)

  20. Consequences of Mesobuthus tamulus gangeticus (Pocock, 1900 envenomation in albino mice

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    MK Chaubey

    2010-01-01

    Full Text Available The present study aimed to investigate the effects of Mesobuthus tamulus gangeticus Pocock (Buthidae venom on albino mice (NIH strain. Whole venom was obtained by electrical stimulation and its toxicity was determined in albino mice by subcutaneous envenomation. The venom LD50 was 2.5 mg kg-1 of mouse body weight. Toxic effects on different biochemical and enzymatic parameters in blood serum and other tissues of albino mice were determined after experimental envenomation with sublethal doses of M. tamulus gangeticus venom. Increased levels of glucose, uric acid and cholesterol, as well as decreased serum total proteins, were observed at 2 and 4 hours after the envenomation. In the liver and muscles, glycogen content dropped after venom injection. Moreover, M. tamulus gangeticus venom elevated the enzymatic activity of acid phosphatase (ACP, lactic dehydrogenase (LDH and alanine aminotransferase (ALT in the serum of albino mice. In conclusion, M. tamulus gangeticus can be considered a lethal scorpion species.

  1. Case Report: Locally advanced skin cancer in an albino, a treatment ...

    African Journals Online (AJOL)

    Case Report: Locally advanced skin cancer in an albino ... headache, anorexia, weight loss, night sweats, dizziness, change in ... This was the case with our patient, whose five ... We need more interventional studies in treatment of locally.

  2. Effect of rifampicin on the lipid profile of albino rats | Peters | Journal ...

    African Journals Online (AJOL)

    The study was designed to investigate the effect of rifampicin on the lipid profile and histopathology of the heart of albino rats. Albino rats (42) were used and rifampicin was administered at 1.10mg/120g body weight (BW) and 0.55mg/120g BW for intervals of 20, 40 and 60days. Result from the study revealed that there was ...

  3. Effect of rifampicin on the kidney of albino rats | Peters | Journal of ...

    African Journals Online (AJOL)

    The study was designed to investigate the effect of rifampicin on the kidney biomarkers and histopathology of kidney of albino rats. 42 albino rats were used and rifampicin was administered at 1.10mg/120gBW and 0.55mg/120gBW for intervals of 20, 40 and 60days.Animals were sacrificed 24 hours after the last day of ...

  4. Profilaxis primaria para tromboembolismo venoso en pacientes ambulatorios con cáncer sometidos a quimioterapia

    Directory of Open Access Journals (Sweden)

    2013-07-01

    Conclusiones de los autores: La tromboprofilaxis primaria con HBPM redujo significativamente la incidencia del TEV sintomático en los pacientes ambulatorios con cáncer tratados con quimioterapia. Sin embargo, la ausencia de poder estadístico obstaculiza la posibilidad de establecer conclusiones definitivas sobre los efectos en cuanto a los resultados principales de seguridad, lo cual obliga a la realización de estudios adicionales para determinar el cociente riesgos/beneficios de la HBPM en este contexto.

  5. RECONSTRUCCIÓN DEL MAXILAR SUPERIOR POSTERIOR ATRÓFICO CON CÉLULAS MADRE MESENQUIMALES

    OpenAIRE

    Martí Pagès, Carles

    2009-01-01

    Se realiza un estudio clínico en el lnstituto de Cirugía Maxilofacial e Implantologia tras pasar el comité ético del Centro Medica Teknon. Es un estudio randomizado, controlado utilizando un diseño tipo "split mouth" en el cual cada paciente sirve de propio control. SE realiza a 5 pacientes, con atrofia posterior del maxilar superior sin posibilidad de instalar implantes fueron tratados con reconstrucción mediante la técnica de elevación sinusal bilateral, rellenando un sena con Bio-as...

  6. Tratamiento de la mordida cruzada anterior con plano inclinado anterior. Efecto sobre los arcos dentales

    OpenAIRE

    Carolina Rodríguez Manjarrés; Jesús Alberto Hernández Silva

    2017-01-01

    Objetivo: Evaluar los cambios dimensionales de los arcos dentales primarios tratados con plano inclinado anterior como método de corrección de la mordida cruzada anterior. Métodos: Se trataron 10 pacientes con edades entre 3 y 5 años afectados con mordida cruzada anterior completa, se colocó un plano inclinado anterior elaborado en acrílico, que estuvo en posición en promedio 8.5 semanas. Se obtuvieron modelos de estudio en 3 momentos T0: antes del tratamiento; T1: 6 meses después de iniciado...

  7. Deficiency in plasma protein synthesis caused by x-ray-induced lethal albino alleles in mouse

    International Nuclear Information System (INIS)

    Garland, R.C.; Satrustegui, J.; Gluecksohn-Waelsch, S.; Cori, C.F.

    1976-01-01

    Plasma protein synthesis was studied in mice bearing x-ray induced lethal mutations at the albino locus. Newborn albino mutants showed a decrease in each of the three principal plasma proteins, albumin, α-fetoprotein, and transferrin, when compared with colored littermate controls. Incorporation of [ 14 C] leucine into plasma proteins of the newborn albinos 30 min after injection was only 1 / 5 that of the controls, but incorporation into total liver protein was only slightly diminished. Incorporation of [ 14 C] leucine into an albumin fraction obtained by immunoprecipitation from livers incubated in vitro in an amino acid mixture was also strongly diminished. Thus, the liver of 18-day-old albino fetuses incorporated into this fraction 1 / 3 and that of newborn albinos 1 / 8 as much as the controls, but in both cases the incorporation into total liver protein was only 25 percent less than in the respective controls. These results indicate that the rather severe structural abnormalities observed in the mutants in the endoplasmic reticulum and the Golgi apparatus are not associated with a general deficiency of hepatic protein synthesis. Instead the data from this and previous work show that the progressive deficiency from fetal life to birth involves certain specific proteins represented by several perinatally developing enzymes and by plasma proteins. It is suggested that the mutational effects observed in these mice are due to deletions involving regulatory rather than structural genes at or near the albino locus

  8. La crítica de Hicks al Tratado del Dinero de Keynes

    Directory of Open Access Journals (Sweden)

    Alexander Tobón

    2004-12-01

    Full Text Available El objetivo de este artículo es mostrar que la crítica que hace Hicks al Tratado del Dinero de Keynes es incorrecta. Para ello, presentamos el modelo de Keynes, mostrando que la igualdad entre la inversión y el ahorro es una condición de equilibrio monetario y no una identidad. Este resultado no puede ser obtenido en el análisis de Hicks.

  9. Tratamiento conservador en pacientes con retinoblastoma bilateral

    Directory of Open Access Journals (Sweden)

    Juan C. Suárez

    2008-11-01

    Full Text Available OBJETIVO: comparar el tratamiento convencional del retinoblastoma bilateral, usado hasta hace algunos años, consistente en radioterapia o enucleación bilateral, con el tratamiento conservador actual que incluye termoterapia transpupilar (TTT o TTT/quimioterapia al menos en un ojo, en niños con diagnóstico de retinoblastoma bilateral. DISEÑO: estudio retrospectivo descriptivo. MUESTRA: 20 pacientes con diagnóstico de retinoblastoma bilateral que consultaron al Hospital Universitario San Vicente de Paúl, de Medellín, Colombia, entre 1997 y 2007. MÉTODO: se hizo enucleación del ojo con el tumor de mayor tamaño. En el otro ojo se hizo tratamiento con TTT, con el láser diodo (810 nm, spot amplio, solo o combinado con otras terapias. RESULTADOS: se dividió a los pacientes en dos grupos: 16 pacientes (32 ojos en el grupo 1 tratados conservadoramente y 4 pacientes (8 ojos en el grupo 2 con tratamiento convencional. El rango de edad fue de 1-72 meses en el grupo 1 y de 1-12 meses en el grupo 2. El tiempo de seguimiento fue de 7-67 meses para el grupo 1 y de 13-73 meses para el grupo 2. En el grupo 1 se hizo enucleación de 16 ojos (50%, radioterapia externa de uno (3,1%, quimioterapia más termoterapia de 5 (15,6% y quimioterapia más termoterapia más crioterapia de 10 (31,3%. En todos los pacientes se logró preservar al menos un ojo. En el grupo 2, se enuclearon 7 ojos (87,5% y se hizo radioterapia externa más enucleación en un paciente (12.5%. Además, todos los pacientes recibieron quimioterapia. CONCLUSIÓN: la terapia conservadora actual consistente en tratamiento local (termoterapia, crioterapia o braquiterapia y quimiorreducción permite preservar al menos un ojo y en algunos casos de los dos, muchas veces con buena agudeza visual, en niños con retinoblastoma bilateral; se evitan así la enucleación bilateral y la radioterapia externa usada en el tratamiento convencional con todos sus efectos secundarios. La enucleación contin

  10. Nostalgia of the Encomienda. Rereading Juan Suárez de Peralta's Tratado del descubrimiento (1589

    Directory of Open Access Journals (Sweden)

    Enrique González González

    2009-10-01

    Full Text Available The work Tratado del descubrimiento de las Yndias y su conquista, written  by the New Spain Creole Juan Suárez de Peralta around 1589, has traditionally been read as just another Conquest chronicle, scarcely interesting in its first chapters, but fully vivid in its “second” part, where the author  tells of the so-called conspiracy of Martín Cortés,  Second Marquis of the Valley of Oaxaca. This paper, however, suggests that the Tratado, in keeping with its title, must be read as a treatise in which Suárez de Peralta pleads for the legitimacy of the encomienda and offers an account of the fateful —as he sees them— consequences  brought about by the Crown's rulings to suppress it. Therefore, the Tratado must be considered within the great debates of the time on how conquered peoples, conquerors and their descendants  should be treated. Although not a professional lawyer, Suárez de Peralta turns out to be a resourceful and convincing writer. Far from offering a linear account  of a series of events, he takes advantage of ambiguity in order  to argue, from different  viewpoints,  on several issues. Sensing that he defends a lost cause, his allegation oozes irony, disillusion, and nostalgia.

  11. O Tratado de Tordesilhas e sua projeção

    Directory of Open Access Journals (Sweden)

    Héctor José Tanzi

    1976-12-01

    Full Text Available (primeiro parágrafo do artigo Em fins de 1479, Castela e Portugal derimiam momentaneamente os trâmites de uma cruel contenda, num tratado de paz pelo qual Fernando e Isabel logravam uma efetiva elevação ao trono e Afonso V de Portugal abandonava a idéia de casar-se com a filha bastarda de Henrique IV, chamada a Beltraneja; esse foi o Tratado das Tercerías de Moura. Porém, ao  mesmo tempo que punha fim ao pleito dinástico, regulamentava-se a questão africana do Reino de Fez e reconhecia-se a Portugal a posse de Guiné, Açores e Cabo Verde, " ... e todas as ilhas que agora se tem descoberto e qualquer outras ilhas que se acharem e se conquistarem das ilhas da Canária para baixo contra Guiné..." no tratado chamado de Alcaçobas.

  12. The Pathophysiological Effects of Acrylamide in Albino Wister Rats

    Directory of Open Access Journals (Sweden)

    Shler Akram Faqe Mahmood

    2016-07-01

    Full Text Available Studies of the pathophysiological effects of suspected compounds are conducted in rodent species, especially rats and mice, to determine the potential toxic effects of a particular compound. In the assessment of acrylamide (ACR which is available as a dietary compound in daily food stuffs, the potential toxicity was determined following the method described earlier. In this study, Albino Wister rats were used and were observed for clinical abnormalities, changes in food consumption, a n d s y m p t o m s o f toxicity over a period of two months following the oral administration of ACR. Among the parameters used to assess the effect of ACR were include ovarian histopathology, blood sugar, haemogram and lipid profile. The most notable clinical abnormalities observed in a few rats were a rough coat and decreased activity. None of the rats died or howedbehavioural change resulting from treatment with ACR. The concentration of serum biochemical parameters and haemogram showed significant differences between normal and treated rats. Histological examination of the ovaries of the treated rats showed great abnormalities as well. In fact, oral ACR doses are practically toxic with regard to rats after exposure for two months at a dose rate of 30 mg/kg, suggesting the compound is quite non-innocuous.

  13. Neurotoxic impact of organophosphate pesticide phosphomedon on the albino rat.

    Science.gov (United States)

    Hazarika, Ranjit

    2014-03-01

    Organophosphate pesticide phosphomedon was exposed to albino rat at a concentration of 35 ppm in the time interval of 30, 45 and 60 days. During the exposure period neurobehavioral symptoms such as reduce food intake, weight loss, increase water intake, low defecation frequency, increase locomotion frequency at high dose were observed. Locomotion frequency were less initially but higher in increasing dose concentration. The result was also different in both the sexes. A decrease social interaction and increase force swimming with increasing dose concentration, which was not significant as comparison to control. A significant histopathological changes observed in three dose concentrations. In 30 days phosphomedon exposure the nuclear shape changes to oval, pear shaped along with fibrosis, lipidosis, 45 days exposure showed the increase number of nucleus, Chromatolysis, inflammatory nucleus, pyknosis. In 60 days test group histopathological picture showed the swelling of cell body, lipidosis, demylination, necrosis in brain cells. Over all result indicated that due to impact of O. P pesticide phosphomedon a severe histopathological changes occurs which was distinctly observed in neurobehavioural changes.

  14. Hepatopancreatic intoxication of lambda cyhalothrin insecticide on albino rats.

    Science.gov (United States)

    Elhalwagy, Manal Ea; Abd-Alrahman, Sherif H; Nahas, A A; Ziada, Reem M; Mohamady, Aziza H

    2015-01-01

    Despite the known adverse effects of lambda cyhalothrin insecticide, little is known about its hepatopancreatic intoxication effects. The present study was carried out to elucidate sub-chronic effect of Karat 2.5% EC formulation of lambda cyhalothrin on male albino rats. To explore the effects of exposure to lambda cyhalothrin on rats and its mechanism, low (1/40 of LD50, 5 mg/kg/day) and high dose (1/4 of LD50, 50 mg/kg/day) lambda cyhalothrin were applied to rats via drinking water for 3 months. Blood samples were collected monthly, and the animals were dissected for liver and pancreas's examination at the end of the experiment. Lambda cyhalothrin administration was associated with the elevation in lipid peroxidation marker, malondialdehyde (MDA), reduction in SH-protein a major marker for antioxidant, as well as basel paraoxonase (PON) in both treated groups throughout the experimental periods. In addition, significant elevations in liver enzymes alanin amino transferase, (ALT), and aspartate amino transferase (AST), as well as plasma acetylcholinesterase (AChE) and glucose level. While, significant reduction in insulin level through the experimental periods. Results of histopathological and histochemical studies showed that lambda cyhalothrin exposure induces liver and pancreatic tissues damage and depletion in glycogen content was pronounced in liver of both treated groups. In conclusion subchronic intoxication with lambda cyhalothrin formulation induced remarkable changes in the examined parameters.

  15. Utilização de efluente tratado em complexo industrial automotivo

    Directory of Open Access Journals (Sweden)

    Sandro Carlos Pohl

    Full Text Available RESUMO Neste trabalho, realizaram-se modificações nos sistemas produtivo e de tratamento de efluentes em um complexo industrial automotivo a fim de possibilitar a utilização do efluente tratado no sistema de torres de resfriamento. Inicialmente, realizou-se um balanço hídrico nos processos industriais para determinar o consumo de água e analisou-se a qualidade do efluente tratado quanto aos parâmetros físico-químicos em dois pontos do sistema de tratamento de efluentes: no decantador secundário (P1 do tratamento físico-químico e na saída da lagoa de polimento (P2. Essas análises mostraram que o efluente tratado no decantador secundário não tem capacidade de atender às especificações da água de circulação das torres de resfriamento sem a realização de muitas alterações em seu tratamento, optando-se pela utilização do efluente tratado na saída da lagoa de polimento após modificações, como: alteração na concentração de ácido fosfórico e de ácido nítrico da solução de limpeza dos tanques de fosfatização, elevação em 50% da capacidade de aeração da lagoa aerada e troca do coagulante sulfato de alumínio pelo cloreto férrico no tratamento físico-químico. Assim, os parâmetros do efluente tratado na lagoa de polimento aproximaram-se aos parâmetros especificados para água de torres de resfriamento. A introdução desse efluente na proporção de 40% do volume da água de circulação na torre de resfriamento resultou em elevação do ciclo de dureza e redução no ciclo de sílica. A utilização de um filtro abrandador na saída da lagoa de polimento proporcionou a redução dos parâmetros de qualidade da água para valores similares aos da água de recirculação nas torres de resfriamento.

  16. La UNASUR y el Protocolo sobre Compromiso con la Democracia

    OpenAIRE

    Luchetti, Javier Fernando

    2012-01-01

    En el presente trabajo describiremos brevemente el proceso que llevó a la UNASUR a añadir a su Tratado Constitutivo, el Protocolo Adicional sobre Compromiso con la Democracia, que pretende constituirse en un apéndice importante en la defensa de las instituciones democráticas y el respeto por los derechos humanos en el sur del continente suramericano, más allá que en otras organizaciones regionales también se menciona que la defensa de la democracia es uno de los pilares de dichas organizacion...

  17. Tolerancia al ejercicio en pacientes con enfermedad pulmonar obstructiva crónica después de un programa de rehabilitación respiratoria

    OpenAIRE

    Meneses Terry, Mercedes R.

    1999-01-01

    Se expusieron los resultados de la aplicación de un programa de rehabilitación respiratoria consistente en la aplicación de ejercicios respiratorios a un grupo de pacientes con asma bronquial, bronquitis crónica y enfisema pulmonar con una duración de 36 sesiones de tratamiento, luego de las cuales se compararon los resultados con los del grupo control que sólo llevó tratamiento con medicamentos. Se observó en los tratados con el programa, un incremento en la tolerancia a los ejercicios. T...

  18. Evaluation of Antinociceptive Activity of Aqueous Extract of Bark of Psidium Guajava in Albino Rats and Albino Mice

    Science.gov (United States)

    Jayasree, T.; Ubedulla, Shaikh; Dixit, Rohit; V S, Manohar; J, Shankar

    2014-01-01

    Background: Psidium guajava is commonly known as guava. Psidium guajava is a medium sized tree belonging to the family Myrtaceae found throughout the tropics. All the parts of the plant, the leaves, followed by the fruits, bark and the roots are used in traditional medicine. The traditional uses of the plant are Antidiarrheal, Antimicrobial Activity, Antimalarial/Antiparasitic Activity, Antitussive and antihyperglycaemic. Leaves are used as Anti-inflammatory, Analgesic and Antinociceptive effects. Aim: To evaluate the antinociceptive activity of aqueous extract of bark of Psidium guajava in albino rats with that of control and standard analgesic drugs aspirin and tramadol. Materials and Methods: Mechanical (Tail clip method) and thermal (Tail flick method using Analgesiometer), 0.6% solution of acetic acid writhing models of nociception were used to evaluate the extract antinociceptive activity. Six groups of animals, each consists of 10 animals, first one as control, second and third as standard drugs, Aspirin and Tramadol, fourth, fifth and sixth groups as text received the extract (100, 200, and 400 mg/ kg) orally 60 min prior to subjection to the respective test. Results: The results obtained demonstrated that aqueous extract of bark of Psidium guajava produced significant antinociceptive response in all the mechanical and thermal-induced nociception models. Conclusion: AEPG antinociceptive activity involves activation of the peripheral and central mechanisms. PMID:25386462

  19. Evaluation of antinociceptive activity of aqueous extract of bark of psidium guajava in albino rats and albino mice.

    Science.gov (United States)

    Sekhar, N Chandra; Jayasree, T; Ubedulla, Shaikh; Dixit, Rohit; V S, Manohar; J, Shankar

    2014-09-01

    Psidium guajava is commonly known as guava. Psidium guajava is a medium sized tree belonging to the family Myrtaceae found throughout the tropics. All the parts of the plant, the leaves, followed by the fruits, bark and the roots are used in traditional medicine. The traditional uses of the plant are Antidiarrheal, Antimicrobial Activity, Antimalarial/Antiparasitic Activity, Antitussive and antihyperglycaemic. Leaves are used as Anti-inflammatory, Analgesic and Antinociceptive effects. To evaluate the antinociceptive activity of aqueous extract of bark of Psidium guajava in albino rats with that of control and standard analgesic drugs aspirin and tramadol. Mechanical (Tail clip method) and thermal (Tail flick method using Analgesiometer), 0.6% solution of acetic acid writhing models of nociception were used to evaluate the extract antinociceptive activity. Six groups of animals, each consists of 10 animals, first one as control, second and third as standard drugs, Aspirin and Tramadol, fourth, fifth and sixth groups as text received the extract (100, 200, and 400 mg/ kg) orally 60 min prior to subjection to the respective test. The results obtained demonstrated that aqueous extract of bark of Psidium guajava produced significant antinociceptive response in all the mechanical and thermal-induced nociception models. AEPG antinociceptive activity involves activation of the peripheral and central mechanisms.

  20. Micronuclei frequency in albino rats exposed to high natural radiation

    International Nuclear Information System (INIS)

    Aneesh, D.; Godwin Wesley, S.

    2013-01-01

    Genotoxicity and DNA damage endpoints are used to evaluate results in the context of cell survival. Genotoxicity in mammalian cells is monitored mostly by using cytokinesis-block micronucleus (CBMN) assay. The score of micronuclei (MN) in peripheral blood lymphocytes can be used as a biomarker and also as a bio-dosimeter of radiation exposure. In the present study the effect of natural radiation on albino rats has been investigated, to find out if there is any increase in MN frequency in peripheral blood lymphocytes. Animals at the age of 2-3 weeks were exposed to natural radiation, at the dose of 10.38 μGyh -1 for a period of 6 months. A parallel control set was also maintained (0.12 μGy h -1 '). Blood samples were collected from both test (exposed to natural radiation) and control rats. Lymphocyte culture was done following 'microculture techniques' for 72 h. Cytochalasin B, at a concentration of 6.0 μg/ml, was added to the lymphocyte cultures at 44 h to block cytokinesis. The frequency of MN was evaluated by scoring a total of 1000 binucleated (BN) cells from one slide. The frequency of MN among the rats exposed to natural radiation was found to be 1.83±0.05 per 1000 BN cells and in the control it was 1.82±0.07 per 1000 BN cells. No statistically significant difference in the MN frequencies of exposed and control groups (p>0.05) was seen. The lower MN frequency in natural radiation exposed rats could be an indication of adaptive response. (author)

  1. Radioprotection of Swiss albino mice by Adhatoda vesica leaf extract

    International Nuclear Information System (INIS)

    Kumar, A.

    2003-01-01

    Full text: The radioprotective role of aqueous extract of Adhatoda vesica leaf extract against radiation induced hematological alterations in peripheral blood of Swiss albino mice was studied at various post-irradiation intervals between 6 hrs to 30 days. Oral administration of Adhatoda vesica leaf extract (800 mg / kg body weight) prior to whole-body irradiation showed a significant protection in terms of survival percentage and hematological parameters. Mice exposed to radiation (8 Gy) without Adhatoda vesica leaf extract pre-treatment exhibited signs of radiation sickness like anorexia, lethargicity, ruffled hairs and diarrhoea and such animals died within 26 days post-irradiation. The dose reduction factor (DRF=1.6) for Adhatoda vesica leaf extract was calculated from LD50/30 values. A significant decline in hematological constituents (RBCs, WBCs, Hb and Hct) was evident till day 15, at later period of observation (day 15 onwards), no animals could survive from control group whereas, in Adhatoda vesica leaf extract pre-treated irradiated group, a gradual recovery was noted in the hematological values. However, these hematological values remained significantly below the normal even till day 30. A significant decrease in GSH was recorded in control animals. Experimental animals showed a significant increase in GSH content (blood as well as liver) with respect to control, but such values remained below normal. A significant increase in TBARS level in liver and serum was evident in control animals. Although, no significant difference was noticed in such levels in normal and Adhatoda vesica leaf extract treated animals. But, a significant decrease was registered in Adhatoda vesica leaf extract pretreated irradiated animals. The results from the present study suggest that Adhatoda vesica leaf extract has radioprotective role in stimulating/protecting the hematopoietic system thereby enhancing the survival and increasing the hematological constituents in peripheral

  2. Hepatotoxicity and genotoxicity of gasoline fumes in albino rats

    Directory of Open Access Journals (Sweden)

    Folarin O. Owagboriaye

    2017-09-01

    Full Text Available Toxic effects of gasoline fumes have been reported, but evidence of its hepatotoxicity and genotoxicity are rare. Therefore, this study assesses hepatotoxicity and genotoxicity of gasoline fumes on forty Albino rats randomly assigned to five experimental treatments (T with eight rats per treatment (T1, T2, T3, T4 and T5. T1(Control was housed in a section of experimental animal house free from gasoline fumes while T2, T3, T4 and T5 were exposed to gasoline fumes in exposure chambers for one, three, five and nine hours daily respectively for twelve weeks. Serum alanine aminotransferase (ALT, aspartate aminotransferase (AST, alkaline phosphatase (ALP and histopathological examination of the liver tissues were used as diagnostic markers to assess liver dysfunction. Genotoxicity test was conducted on the lung tissues using randomly amplified polymorphic DNA fingerprinting polymerase chain reaction (RAPD PCR technique. Significant increase (p < 0.05 in the level of ALT, AST and ALP for T2, T3, T4 and T5 compared to T1 were recorded. Photomicrograph examination of the liver sections of T1 showed hepatic tissue with normal liver cell architecture while that of T2, T3, T4 and T5 revealed degenerative changes in the ultrastructural integrity of the hepatic cells. Genotoxicity test revealed DNA bands at a reducing intensity from T1 to T5. Dendrogram showed DNA damage in the lungs of T3, T4 and T5 were closely similar and the genotoxic impact was more in T3. Frequent exposure to gasoline fumes was observed to induce hepatoxicity and genotoxicity, hence impairing the normal liver function and gene structure.

  3. Chronic alcoholism-mediated metabolic disorders in albino rat testes.

    Science.gov (United States)

    Shayakhmetova, Ganna M; Bondarenko, Larysa B; Matvienko, Anatoliy V; Kovalenko, Valentina M

    2014-09-01

    There is good evidence for impairment of spermatogenesis and reductions in sperm counts and testosterone levels in chronic alcoholics. The mechanisms for these effects have not yet been studied in detail. The consequences of chronic alcohol consumption on the structure and/or metabolism of testis cell macromolecules require to be intensively investigated. The present work reports the effects of chronic alcoholism on contents of free amino acids, levels of cytochrome P450 3A2 (CYP3A2) mRNA expression and DNA fragmentation, as well as on contents of different cholesterol fractions and protein thiol groups in rat testes. Wistar albino male rats were divided into two groups: I - control (intact animals), II - chronic alcoholism (15% ethanol self-administration during 150 days). Following 150 days of alcohol consumption, testicular free amino acid content was found to be significantly changed as compared with control. The most profound changes were registered for contents of lysine (-53%) and methionine (+133%). The intensity of DNA fragmentation in alcohol-treated rat testes was considerably increased, on the contrary CYP3A2 mRNA expression in testis cells was inhibited, testicular contents of total and etherified cholesterol increased by 25% and 45% respectively, and protein SH-groups decreased by 13%. Multidirectional changes of the activities of testicular dehydrogenases were detected. We thus obtained complex assessment of chronic alcoholism effects in male gonads, affecting especially amino acid, protein, ATP and NADPH metabolism. Our results demonstrated profound changes in testes on the level of proteome and genome. We suggest that the revealed metabolic disorders can have negative implication on cellular regulation of spermatogenesis under long-term ethanol exposure.

  4. Biological dosimetry of patients with differenced carcinoma of thyroid treated with Iodine-131; Dosimetria biologica de pacientes con carcinoma diferenciado de tiroides tratados con Iodo-131

    Energy Technology Data Exchange (ETDEWEB)

    Vallerga, M. B.; Rojo, A.M.; Taja, M.R.; Deluca, G.; Di Giorgio, M. [Autoridad Regulatoria Nuclear Av. Del Libertador 8250 (C1429BNP). Buenos Aires (Argentina); Fadel, A. [Hospital General de Agudos Dr. Carlos Durand Av. Diaz Velez 5044. Buenos Aires (Argentina); Cabrejas, M.; Valdivieso, C. [Hospital de Clfnicas Jose de San Martin Av. Cordoba 2351 (CP1120). Buenos Aires (Argentina)]. e-mail: mvallerg@cae.arn.gov.ar

    2006-07-01

    The administration of I-131 to patient with Differentiated Thyroid Carcinoma (CaDiT) it is used inside the therapeutic outline as later step to the thyroidectomy. However, the good activity to give is of difficult determination due to factors such as, the variability in the capacity of tumoral reception of the I-131, distribution of the pharmaceutical, physiologic status, other associate pathologies, grade of advance of the illness, and previous treatments. Additionally, the activity to administer is dependent of the dose of tolerance in the healthy tissues; superior dose to 2 Gy in bone marrow, its could drive to myelotoxicity. At the moment, the form more extended of administration it is the empiric prescription that considers clinical parameters and of laboratory for their determination. Presently work, the protocol of applied treatment incorporates the evaluation for internal dosimetry and biological dosimetry to estimate absorbed dose in bone marrow. The biological estimate of the dose of these patients is based on the quantification of chromosomal aberrations whose frequency is referred to a curve-dose response in which the lymphocytes is irradiated in vitro with I-131, allowing to determine the in vivo dose to the patient's circulating lymphocytes. The objective of the present work is to determine the applicability of different cytogenetic essays in the estimate of the absorbed dose to the whole body or specific organs. Three patients were evaluated with CaDiT. Their treatment protocol consisted on a tracer administration of radioactive iodine of 74 - 111 MBq (2 - 3 mCi) and a therapy 7,4 - 11,1 GBq (200 - 300 mCi). Previous to the tracer administration and 8 days post-therapeutic administration took samples of veined blood that were evaluated by biological dosimetry by means of the application of the techniques: conventional cytogenetic Micronucleus and FISH (Hybridization in situ by Fluorescence). Starting from the frequencies of observed chromosomal aberrations it was considered absorbed dose to whole body. The obtained doses were compared by the different biological methods used. The evaluation by internal dosimetry of the data obtained tracer post-activity allowed to personalize the activity of I-131 to administer, starting from physical-mathematical models that consider the particular biokinetics of each patient (MIRD methodology). The doses estimated by the used biological dosemeters were consistent among them. It was discussed its scopes and limitations to be applied in the validation of the dosimetric estimation based on models, in order to administer a therapeutic dose protecting the patient of the adverse effects of the internal radiotherapy in organs that are not target of the same one. The acquired experience is considered of utility to give answer in cases of radioiodine incorporation in occupationally exposed personnel. (Author)

  5. Crisis de pánico en un paciente con acné tratado con isotretinoína: Caso clínico

    OpenAIRE

    Poblete A,Catalina; Herskovic M,Viviana; Eva C,Pedro

    2006-01-01

    The use of isotretinoin as a treatment for acne is related to psychiatric syndromes such as psychosis and depression. On the other hand, several drugs have been identified as causing panic attacks. A relationship between dermatologic and psychiatric disease has also been established. We report a 20 year-old male who started to suffer panic attacks after using isotretinoin for acne

  6. Characteristic, inheritance and breeding application of rice mutants with greenable albino leaf

    International Nuclear Information System (INIS)

    Fang Xiantao; Ma Hongli; Zhao Fuyuan; Zhang Qingqi; Zhang Shubiao

    2009-01-01

    Inheritance and main agronomic traits of photo-thermo-sensitive genic male sterile line with green-revertible albino leaf were investigated. The results indicated that the mutants might be divided into three types: albino regreening type (W2, W3, W4 and W10), albino to kelly type (W9) and abino-regreening-albino-regreening type (W1 and W7). Genetic study indicated that green-revertible albino leaf color trait of the mutants as controlled by a single recessive gene. These mutants had similar agronomic traits and fertility characteristics to the corresponding male sterile line 'Peiai 64S'. The hybrids of these mutants had similar characteristics with original-hybrids in plant type, developing of tillers and plant height. The yield components of the mutant hybrids were different depending on different mutants. The yield potential of hybrids of W1, W2 and W3 were similar to the original-hybrid. The results also indicated that W1, W2 and W3 had breeding application value. (authors)

  7. Renegociação do Tratado de Itaípu entre Lugo e Lula

    OpenAIRE

    Almeida, Giordano Sousa de

    2015-01-01

    Este trabalho objetiva analisar o processo de ratificação do ajuste no Anexo C do Tratado de Itaipu, ocorrido, no Congresso Nacional brasileiro, em decorrência do acordo assinando entre o presidente brasileiro Luiz Inácio Lula da Silva e seu homólogo paraguaio Fernando Armindo Lugo de Méndez, em julho de 2009. Especificamente, procurou-se entender se haveria alguma relação especial existente entre os Governos brasileiro, chefiado pelo Partido dos Trabalhadores, e o paraguaio, chefiado por ...

  8. STUDIES ON INDUCED HEPATOTOXICITY IN MALE ALBINO RATS (RATTUS NORVEGICUS)

    International Nuclear Information System (INIS)

    ABULYAZID, I.; ABBAS, O.A.; FAYEZ, V.

    2008-01-01

    Levanox, a hepato protective drug, and garlic powder have been considered as safe anti-oxidant agents. The present investigation refers to biochemical and molecular studies to evaluate the protective role of levanox and/or garlic powder toward CCl4-induced toxicity in adult male albino rats. CCl4 intoxication was attempted using a dose of 0.03 ml/kg of rat body weight.Pre-treatment with levanox (one capsule/ kg of rat body weight, each capsule contains 100 mg catechu, 7.5 mg dandelion, 75 mg termiric 2 % curcumin , 17.5 mg silymarin, 100 mg lecithin) was more effective than garlic powder (100mg/kg of rat body weight) in reducing CCl4-induced hepatotoxicity as revealed by its higher potency in reducing elevation of aspartate (AST) and alanine (ALT) aminotransferases in serum. Serum of control rats and those treated with levanox or garlic or CCl4 produced 13 types of proteins, differing in the molecular weight (MW) and densities, while those of levanox + garlic or garlic +CCl4 produced 14 bands differing in the MW and densities. The similarity index at the epigenetic level was also studied using the primers under study. The control sample produced one amplified DNA fragment with Rf of 0.73 and a molecular size (MS) of 67 base pair (bp) . Using the same primers, no amplified DNA fragment with the same MS was produced in the sample taken from levanox + garlic treated group.OPA-2 primer of sequence 5?- AGA TGC AGC C-3? produced one amplified DNA band with MS of 292 bp and Rf of 0.46 . However, the same primer produced one amplified DNA characteristic band with a molecular size of 363 bp and Rf of 0.43 in the sample of levanox + garlic group.In the control sample, OPA-4 primer of sequence 5? - ACG CAC AAC C-3? produced one amplified DNA band of MS of 299 bp and Rf of 0.43. The same primer produced one amplified characteristic DNA band with MS of 363 bp and Rf of 0.43 in the sample of levanox + garlic group.Dual treatment with levanox and garlic powder resulted in a

  9. Ocular toxicity of AUY922 in pigmented and albino rats

    International Nuclear Information System (INIS)

    Roman, Danielle; VerHoeve, James; Schadt, Heiko; Vicart, Axel; Walker, Ursula Junker; Turner, Oliver; Richardson, Terrilyn A.; Wolford, Suzanne T.; Miller, Paul E.; Zhou, Wei; Lu, Hong; Akimov, Mikhail; Kluwe, William

    2016-01-01

    AUY922, a heat shock protein 90 inhibitor is associated with ocular adverse events (AEs). To provide a better understanding of ocular AEs in patients, 4 investigative studies were performed in a step-wise approach to assess retinal structure and function in pigmented (Brown Norway) and albino (Wistar) rats. In rats administered 30 mg/kg of AUY922, the AUC 0–24 h and C max are comparable to that in patients at 70 mg/m 2 . AUY922 at ≥ 30 mg/kg was poorly tolerated by rats with morbidity or mortality generally after the third weekly treatment. Electroretinography (ERG) changes were observed at doses ≥ 30 mg/kg. The ERG changes were dose dependent, consistent with an effect on the photoreceptors, and fully reversible. The ERG effects could not be minimized by decreasing the C max while maintaining AUC. Histopathological changes were seen mainly when rats were administered AUY922 at 100 mg/kg. The 2-hour infusion of AUY922 at 100 mg/kg caused disorganization of the outer segment photoreceptor morphology in male Brown Norway rats; the severity of the disorganization increased with the number of administrations, but was reversible during a 4-week posttreatment period. There was no major difference in ocular response between Brown Norway and Wistar rats. No changes in serum iron levels, and no changes in rhodopsin, PDE6α, β-transducin concentrations, or retinal pigment epithelium-specific protein RPE65 expression were observed after single and multiple infusions of AUY922 at 100 mg/kg compared to vehicle-treated controls. AUY922 retinal toxicity in rats recapitulates and further characterizes that reported in patients and is shown to be reversible, while a precise molecular mechanism for the effect was not determined. - Highlights: • Ocular toxicity of AUY922 was assessed in Brown Norway and Wistar rats. • AUY922 at ≥ 30 mg/kg was generally not well tolerated by rats. • Electroretinography (ERG) changes were observed at doses ≥ 30 mg/kg. • ERG changes

  10. Ocular toxicity of AUY922 in pigmented and albino rats

    Energy Technology Data Exchange (ETDEWEB)

    Roman, Danielle, E-mail: danielle.roman@novartis.com [Preclinical Safety, Novartis Pharma AG, Basel (Switzerland); VerHoeve, James [Ocular Services on Demand, Madison, WI (United States); University of Wisconsin School of Medicine and Public Health, Madison, WI (United States); Schadt, Heiko; Vicart, Axel; Walker, Ursula Junker [Preclinical Safety, Novartis Pharma AG, Basel (Switzerland); Turner, Oliver [Preclinical Safety, Novartis Pharmaceuticals Corporation, East Hanover, NJ (United States); Richardson, Terrilyn A. [Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH (United States); Wolford, Suzanne T. [Covance Laboratories Inc., Madison, WI (United States); Miller, Paul E. [Comparative Ophthalmic Research Laboratory (CORL), University of Wisconsin, Veterinary Medical Teaching Hospital, Madison, WI (United States); Zhou, Wei [Drug Metabolism and Pharmacokinetics, Novartis Pharmaceuticals Corporation, East Hanover, NJ (United States); Lu, Hong [Biologics Clinical Pharmacology, Janssen BioTherapeutics at Johnson & Johnson, Spring House, PA (United States); Akimov, Mikhail [Oncology Global Development, Novartis Pharma AG, Basel (Switzerland); Kluwe, William [Preclinical Safety, Novartis Pharmaceuticals Corporation, East Hanover, NJ (United States)

    2016-10-15

    AUY922, a heat shock protein 90 inhibitor is associated with ocular adverse events (AEs). To provide a better understanding of ocular AEs in patients, 4 investigative studies were performed in a step-wise approach to assess retinal structure and function in pigmented (Brown Norway) and albino (Wistar) rats. In rats administered 30 mg/kg of AUY922, the AUC{sub 0–24} {sub h} and C{sub max} are comparable to that in patients at 70 mg/m{sup 2}. AUY922 at ≥ 30 mg/kg was poorly tolerated by rats with morbidity or mortality generally after the third weekly treatment. Electroretinography (ERG) changes were observed at doses ≥ 30 mg/kg. The ERG changes were dose dependent, consistent with an effect on the photoreceptors, and fully reversible. The ERG effects could not be minimized by decreasing the C{sub max} while maintaining AUC. Histopathological changes were seen mainly when rats were administered AUY922 at 100 mg/kg. The 2-hour infusion of AUY922 at 100 mg/kg caused disorganization of the outer segment photoreceptor morphology in male Brown Norway rats; the severity of the disorganization increased with the number of administrations, but was reversible during a 4-week posttreatment period. There was no major difference in ocular response between Brown Norway and Wistar rats. No changes in serum iron levels, and no changes in rhodopsin, PDE6α, β-transducin concentrations, or retinal pigment epithelium-specific protein RPE65 expression were observed after single and multiple infusions of AUY922 at 100 mg/kg compared to vehicle-treated controls. AUY922 retinal toxicity in rats recapitulates and further characterizes that reported in patients and is shown to be reversible, while a precise molecular mechanism for the effect was not determined. - Highlights: • Ocular toxicity of AUY922 was assessed in Brown Norway and Wistar rats. • AUY922 at ≥ 30 mg/kg was generally not well tolerated by rats. • Electroretinography (ERG) changes were observed at doses ≥ 30

  11. Antidiarrhoeal efficacy of Mangifera indica seed kernel on Swiss albino mice.

    Science.gov (United States)

    Rajan, S; Suganya, H; Thirunalasundari, T; Jeeva, S

    2012-08-01

    To examine the antidiarrhoeal activity of alcoholic and aqueous seed kernel extract of Mangifera indica (M. indica) on castor oil-induced diarrhoeal activity in Swiss albino mice. Mango seed kernels were processed and extracted using alcohol and water. Antidiarrhoeal activity of the extracts were assessed using intestinal motility and faecal score methods. Aqueous and alcoholic extracts of M. indica significantly reduced intestinal motility and faecal score in Swiss albino mice. The present study shows the traditional claim on the use of M. indica seed kernel for treating diarrhoea in Southern parts of India. Copyright © 2012 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

  12. EL SISTEMA EUROPEO DE DERECHOS FUNDAMENTALES TRAS LA ENTRADA EN VIGOR DEL TRATADO DE LISBOA

    Directory of Open Access Journals (Sweden)

    Lorenzo Martín-Retortillo Baquer

    2011-07-01

    Full Text Available Resumen: En 1947 se pusieron las bases de lo que llegaría a ser la Unión Europea, a modo de organización comercial para sectores concretos, complejo que iría creciendo, ampliándose los fines y la organización, a la par que se fraguaba un complejo ordenamiento jurídico. Se hizo necesario alcanzar una declaración de derechos que incluyera los modernos derechos sociales. En el trabajo se estudia la compleja historia de la obtención de la declaración, la “Carta de Derechos Fundamentales de la Unión Europea”, que, al fin, entraría en vigor el 1.XII.2009, a la par que el último de los Tratados de la Unión, el Tratado de Lisboa.Abstract: The European Union was founded in 1947 as a concrete trade organization but it started to grown. The aims and the organization had increased and in the meantime a complex law system was set up. It was convenient to get a solid bill of rights including the modern social rights. The paper studies the complicate story of how to obtain the bill of rights –the “Carta of Fundamentals Rights of the European Union”- which formally came into effect the 1.XII.2099 at the same time that the last Treaty of the Union, the Treaty of Lison.

  13. ARTRODESIS TIBIOTALOCALCANEA CON PLACA PHILOS: EXPERIENCIA EN EL HOSPITAL MILITAR CENTRAL. ENERO 2007 A DICIEMBRE DE 2009

    OpenAIRE

    MUÑOZ FALLA, GERARDO ALEXI; DELGADO NEIRA, ALEJANDRO; ENRIQUE GAMBA, CESAR; HERNÁNDEZ PERDOMO, EDGAR

    2011-01-01

    Estudio descriptivo observacional, retrospectivo tipo serie de casos, realizado entre enero de 2007 y diciembre de 2009 en el Hospital Militar Central. Fueron tratados 21 pacientes con artrosis de la articulación tibio talar y subtalar de etiología diversa, con seguimiento mínimo de 6 meses. Se evaluó; la función pre operatoria y post operatoria por medio de la escala AOFAS, el dolor mediante la escala visual análoga, el tiempo de consolidación con controles radiográficos, el tipo de injerto ...

  14. Evaluación de una crema dental con extracto de cuproclorofila

    OpenAIRE

    Estela Gispert Abreu; Elena Cantillo Estrada; Aracelys Rivero López; Bertha Oramas Rodríguez; Esther Barreto Banderas

    2001-01-01

    Se evaluó el efecto del cepillado con crema dental que contiene extracto de cuproclorofila en 23 niños de 10 años (otros 23 niños se tomaron como control). Se observaron reducciones significativas según chi cuadrado en cuanto a la infección por Streptococcus mutans, la acumulación de placa dentobacteriana y en la inflamación gingival del grupo tratado con respecto al control.The effect of tooth brushing with a dentrifice containing cuprochlorophyll extract in 23 children aged 10 (other 23 wer...

  15. Estudio comparativo de las maloclusiones de clase III tratadas con y sin cirugía

    OpenAIRE

    Martínez Asúnsolo, Pascual

    2014-01-01

    El objetivo de la presente tesis fue determinar si existen diferencias en la inclinación de los incisivos superiores e inferiores en pacientes de clase III tratados con cirugía o únicamente con “camuflaje ortodóncico”, así como su repercusión en la relación esquelética final. Para ello se realizó un estudio clínico comparativo y retrospectivo en la unidad docente de Ortodoncia del departamento de Estomatología de la Universidad de Valencia. La muestra consistió en 56 pacientes que cump...

  16. Reconstrucción de lesiones osteocondrales con fibra de carbono

    OpenAIRE

    Carranza Bencano, A.; Armas-Padrón, J. R.; Lozano, Mª A.

    1998-01-01

    Objetivo: Estudiar a largo plazo la evolución histológica de defectos osteocondrales de la rótula de conejos tratados con fibra de carbono. Material y Método: 18 conejos de raza gigante español, variedad parda, de ambos sexos, con un peso aproximado de 1.5 a 2 Kg y 18 discos Cleveland de fibra de carbono de 8 mm de diámetro (Medicarb®, fabricado por Leyland Medical International). Creación de un defecto de 6 mm. de diámetro en la superficie articular de la rótula, hasta alcanzar el teji...

  17. Efectividad de la acupuntura con tachuela en afectados por epicondilitis

    Directory of Open Access Journals (Sweden)

    Mercedes Gay Muguercia

    2014-06-01

    Full Text Available Se realizó una intervención terapéutica en 20 pacientes con epicondilitis, remitidos de la consulta de Ortopedia al Departamento de Medicina Natural Tradicional del Hospital Provincial Docente Clinicoquirúrgico "Saturnino Lora Torres" de Santiago de Cuba, de septiembre a diciembre de 2012, con vistas a determinar la efectividad de la acupuntura con tachuela en ellos. Los afectados fueron valorados y, de forma aleatoria, se les distribuyó en 2 grupos de 10 integrantes cada uno: el de estudio, que recibió acupuntura (agujas de 0,2 mm de forma permanente en los puntos Ashi y en el IG-11, y el de control, tratado convencionalmente con antiinflamatorios y analgésicos. Luego de aplicadas las terapias, los pacientes fueron valorados a los 5, 10 y 15 días, teniendo en cuenta el cuadro clínico dado por dolor, inflamación e impotencia funcional. La regresión de los síntomas se evaluó por la escala visual analógica, y se obtuvo una efectividad marcada del tratamiento con acupuntura en relación con el medicamentoso

  18. Citotoxicidad del cadmio en hepatocitos de ratón albino y sus posibles implicaciones en ambientes tropicales

    Directory of Open Access Journals (Sweden)

    Letty Marcano

    2006-06-01

    Full Text Available Se realizó un análisis de las alteraciones fenotípicas, estructurales y ultraestructurales inducidas por Cd+2 en hepatocitos de ratón albino suizo. El metal fue suministrado vía oral en solución acuosa de CdCl2 durante 100 días a concentraciones de 50 ppm, 100 ppm y 150 ppm, en los controles la solución de cadmio fue sustituida por agua destilada. Las muestras fueron procesadas utilizando la técnica de inclusión en parafina y teñidas con hematoxilina- eosina para microscopía óptica y por la técnica convencional para microscopía electrónica de transmisión. Identificamos cambios fenotípicos (diferencias entre talla y peso y fisiológicos (debilidad muscular e intranquilidad; a nivel histológico, pérdida de la disposición trabecular y de la arquitectura lobulillar, focos de aglomerados linfocíticos, vacuolización, dilatación de sinosoides y de la vena central. El estudio ultraestructural señala diversas alteraciones tales como: nucléolo con un elevado número de centros fibrilares (50 ppm; voluminosas gotas de lípidos en el citoplasma, retículo endoplasmático rugoso distendido, vacuolización citoplasmática, lisosomas y peroxisomas alterados (100 ppm; núcleos contraídos con cromatina condensada, dilatación en el espacio intracelular y áreas de pérdida mitocondrial y fibrilar (150 ppm. Sugerimos que el cadmio ejerce un efecto tóxico en las células hepáticas el cual se hace más severo con el aumento de la concentración, llevando a la necrosis celular.Cadmium citotoxicity in mice hepatocytes and impications on tropical environments. We analyzed phenotypic, structural and ultrastructural alterations induced by Cd+2 in hepatocytes extracted from Swiss Albino mice. Cadmium was given orally in watery solution of CdCl2 during 100 days at concentrations of 50 ppm, 100 ppm and 150 ppm. In controls, distilled water alone was used. The samples were processed with the paraffin inclusion and hematoxilin-eosin coloration

  19. Eficacia del tratamiento tópico con Vimang® en pacientes con estomatitis subprótesis

    Directory of Open Access Journals (Sweden)

    Laritza Coureaux Rojas

    2013-10-01

    Full Text Available Se efectuó un ensayo clínico terapéutico controlado de fase III en 120 pacientes con estomatitis subprótesis, atendidos en la Clínica Estomatológica Provincial Docente "Mártires del Moncada" de Santiago de Cuba, desde junio de 2010 hasta mayo de 2011, con vistas a evaluar la eficacia del tratamiento tópico con té de Vimang® en dichos pacientes. Se conformaron 2 grupos de 60 integrantes cada uno (de estudio y de control. Los primeros fueron tratados con enjuagatorios fríos de dicho té 4 veces al día y los segundos con el mismo tratamiento más vitaminas. Se utilizaron el porcentaje para variables cualitativas, así como la media aritmética y la desviación estándar para variables cuantitativas. Todos los integrantes del grupo de estudio se curaron y disminuyó el gasto de material, pero el costo-efectividad fue mayor por ser menor el tiempo de curación. El té de Vimang® resultó eficaz para eliminar las manifestaciones clínicas de esa lesión y no hubo reacciones adversas, de manera que se logró la curación de los afectados con ahorro de tiempo y recursos.

  20. Legitimidad y finalidad de los capítulos de propiedad intelectual en los tratados de libre comercio (TLC)

    OpenAIRE

    Frankel, Susy

    2011-01-01

    Una visión analítica de la realidad actual permite apreciar un auge de los Tratados de Libre Comercio, mientras se presenta un estancamiento en las negociaciones multilaterales de comercio. Si bien la negociación de los TLC no se limita a los países desarrollados, los negociados por los países en desarrollo no tienden a contemplar mejoras en los estándares de propiedad intelectual. Algunos de los capítulos relativos a la propiedad intelectual incluidos en los Tratados de Libre Comercio simple...

  1. Obliteración de fracturas de seno frontal con colgajos pediculados

    Directory of Open Access Journals (Sweden)

    J. Pefaure

    2014-03-01

    Full Text Available El compromiso del seno frontal con fractura de sus paredes es un tipo de lesión infrecuente, en torno al 5-12% de todas las fracturas faciales. Suele asociarse a lesiones intracraneales, oftalmológicas y a otras fracturas máxilofaciales y cuando conlleva fractura de la pared posterior de seno frontal requiere tratamiento inmediato, siendo necesaria la obliteración del seno frontal debido a la comunicación con meninges y lóbulo frontal, con el riesgo infeccioso que ello representa. Tratamos 18 pacientes con traumatismos craneofaciales y fracturas del seno frontal con compromiso de su pared posterior en el periodo comprendido entre 2007 y 2011; 8 mujeres y 10 varones con edades comprendidas entre los 15 y los 64 años. Todos los casos fueron tratados con reducción y osteosíntesis por vía abierta con distintos abordajes y realizamos en todos colgajos pediculados de vecindad. La vitalidad de los colgajos fue del 100% . Certificamos el posicionamiento correcto mediante tomografía axial computarizada. El tratamiento de las fracturas del seno frontal con compromiso de su pared posterior o del conducto nasofrontal requiere obliteración con tejido vascularizado para evitar comunicaciones con la cavidad nasal.

  2. Farmacovigilancia de la sertralina en pacientes cubanos con episodio de depresión mayor

    Directory of Open Access Journals (Sweden)

    Leslie Pérez Ruiz

    2011-03-01

    Full Text Available En la depresión predominan síntomas como: desinterés, fatiga, sentimientos de inutilidad, desconcentración, deseos de muerte e insomnio. Entre los medicamentos para tratarla se encuentra la sertralina. Con el objetivo de evaluar su seguridad, se revisaron 40 historias clínicas y cuadernos de recogida de datos de los pacientes incluidos en ensayo clínico fase III, aletatorizado, controlado y a doble ciegas: "Uso de sertralina en pacientes con episodio de depresión mayor", pertenecientes al Hospital "Dr. Gustavo Aldereguía Lima". Se obtuvieron datos demográficos, clínicos y eventos adversos, con los cuales se realizó un estudio descriptivo, observacional y transversal que clasifica como un estudio de utilización de medicamentos sobre consecuencias prácticas. La información fue analizada mediante SPSS, versión 13.0 para Windows. De los 40 pacientes incluidos, 24 presentaron eventos adversos para un 60 %; de ellos, 16 (67 % en el grupo tratado con sertralina y 8 (33 % en los tratados con placebo. Los eventos adversos más frecuentes fueron: disminución de peso, sequedad bucal, cefalea, diarreas y náuseas. En su mayoría resultaron de intensidad ligera, causalidad probable y sin necesidad de tratamiento. El uso del fármaco se consideró seguro en el tratamiento de estos pacientes.

  3. Lipid Lowering Efficacy of Pennisetum glaucum Bran in Hyperlipidemic Albino Rats

    Directory of Open Access Journals (Sweden)

    I. Javed*, B. Aslam, M. Z. Khan1, Zia-Ur-Rahman, F. Muhammad and M. K. Saleemi1

    2012-05-01

    Full Text Available The objective of the study was to determine lipid lowering efficacy of Pennisetum (P glaucum (Pearl millet, locally known as bajra, bran in hyperlipidemia albino rats. Simvastatin, (Tablet survive®, was used as cholesterol lowering synthetic drug. The period of 0-15 days was considered as a lead-in period to induce hyperlipidemia with atherogenic diet in albino rats. P. glaucum bran at dose rate of 2, 4 and 6 g/kg BW showed lipid lowering efficacy in hyperlipidemic rats at post-treatment days 30, 45 and 60. At the level of 6 g/kg, P. glaucum bran was able to produce a significant (P<0.05 increase in HDL- cholesterol (47% and fall in other lipid profile parameters i.e. total lipids (41%, triglycerides(48%, total cholesterol (39% and LDL- cholesterol (55%. P. glaucum 6 g/kg also reduced total cholesterol in liver tissue and increased fecal bile acid secretion. The results of present study suggest that 6 g/kg P. glaucum bran and 0.6 mg/kg Simvastatin were equally effective in treating hyperlipidemia in albino rats. Moreover, the potency of P. glaucum for stimulating fecal bile acid secretion in albino rats may safely be conceived, at least, as a part of mechanisms for its antihyperlipidemic efficacy.

  4. Biochemical Changes in the Serum and Liver of albino rats exposed ...

    African Journals Online (AJOL)

    Biochemical changes in the serum and liver of albino rats chronically exposed to rats administered 5gk-1 , 7.5gk-1 and 15gk-1 of gasoline , kerosine and crude petroleum(bonny light) respectively were studied. The petroleum samples were administered intraperitoneally and the biochemical changes in the rat serum and the ...

  5. Effect of honey consumption on intestinal motility in male albino rats ...

    African Journals Online (AJOL)

    Summary: This study investigated the effects of honey on intestinal motility and transit using twenty (20) male albino rats of Wistar strain weighing 210-220g. The rats were randomly grouped into control and honey-fed (test) groups of ten (10) rats each. The control group was fed on normal rat chow ( Pfizer Company, Nigeria ) ...

  6. Influence of continuous microwave irradiation of low intensity on the behaviour of albino rats

    International Nuclear Information System (INIS)

    Rynskov, V.V.

    1985-01-01

    A study was made of a single 10 min exposure of albino rats to microwaves (6 GHz, 0.2 MW/cm 2 ) on their orientative-trying reaction. The locomotive activity, attentiveness and trying activity of the experimental animals were found to increase

  7. Therapeutic Effects of Cassia angustifolia in a Cadmium Induced Hepatotoxicity Assay Conducted in Male Albino Rats

    Directory of Open Access Journals (Sweden)

    Muhammad Tahir Haidry

    2016-04-01

    Full Text Available The present study aims to investigate the therapeutic effects of Senna plant (Cassia angustifolia L. in a cadmium-induced hepatotoxicity assay by evaluating the activity of alanine transaminase (ALT, aspartate transaminase (AST, alkaline phosphatase (ALP and total protein (TP in the albino rats’ serum. A total of 30 white albino rats were taken and divided into three groups; each group comprising ten rats. The group A was taken as a control group; group B was given cadmium chloride concentration of 5 mg/kg (body weight for 42 days; and group C was given cadmium chloride 5 mg/kg body weight for first 21 days and then extract of C. angustifolia 100 mg/kg (body weight was given for remaining 21 days. The analysis were performed twice i.e., on 21stst day and 42nd day. Results illustrated that the concentration of cadmium was significantly elevated (P<0.05 at the levels of serum biochemical markers namely ALT, AST, ALP which lowered the protein levels in albino rats. Moreover, treatment with the standard extracts of C. angustifolia observed to reverse the effects of the cadmium significantly (P<0.05. It is concluded that the C. angustifolia had hepatoprotective effects and therapeutic potential against the cadmium-induced hepatotoxicity in albino rats.

  8. Effect of calcium bentonite on lipid parameters in Wistar albino rat ...

    African Journals Online (AJOL)

    The in vivo effect of Nigerian calcium bentonite clay on rat plasma cholesterol and triglyceride levels of Wistar albino rats was investigated. The rats were fed for a period of four weeks with varying concentrations of the bentonite clay, and the cholesterol and triglyceride levels determined using spectrophotometric methods.

  9. Effects of dietary protein quality and quantity on albino rat tissue ...

    African Journals Online (AJOL)

    Effects of dietary protein quality and quantity on albino rat tissue serum protein, erythrocyte fragility and bone mineral content. ... The 20% protein diet was a commercial diet better in nutrient composition and quality than the diet containing 17 and 15% protein formulated in our laboratory. At the end of 21 days, kidney, testes, ...

  10. Ostracism of an albino individual by a group of pigmented catfish.

    Directory of Open Access Journals (Sweden)

    Ondřej Slavík

    Full Text Available Physiological and behavioural constraints hinder albino individuals. Albino animals are rare in the wild; this trait is associated with easy detection by predators, non-native or damaged environments, and exclusively aphotic environments in total darkness. The social aspect of albinism is reported only for human beings, and the effect is distinguishable in time and space when social benefits, are used to a limited the extent. Thus far, the social consequences of albinism for animals remain unknown. We used socially established groups of the pigmented catfish, (Silurus glanis, to observe space and temporal distance detachment of albino specimens in laboratory conditions. The albino fish were separated at larger distances from the group than pigmented individuals with the same social status determined by familiarity, and this asymmetry also varied in time. Albinism-related ostracism results in a solitary existence, usually followed by enhanced predation risk. The motivation for an individual's exclusion from a group appears to be the avoidance of the predation risk that increases not only for an odd individual but also for conspecifics within a group. Our findings indicate a role for albinism in behavioural processes related to sociality in a group of conspecifics.

  11. Effect of Cassava based diet on lipids concentration in albino rats ...

    African Journals Online (AJOL)

    Michael Horsfall

    Environ. Manage. March 2013. Vol. 17 (1) 15-19. Full-text Available Online at ... compared with Petroleum fed albino rats (P<0.05) suggesting that gari ... and sugar) during processing. ). ... It was mixed and incubated for 5 minutes at 370C.

  12. Effect of antiretroviral drug (arved) on hepatic enzymes in albino rats ...

    African Journals Online (AJOL)

    ... with very little or no laboratory monitory, limited attention has been given to side effects ... A total of fifty two (52) albino rats were randomly divided into four groups ... The mean value of ALT activity for the drug in dose dependent manner was ...

  13. Effect of ovariectomy on the levels of plasma sex hormones in albino ...

    African Journals Online (AJOL)

    The study was carried out to evaluate the levels of sex hormones (testosterone, progesterone & estradiol), six weeks post normal ovariectomy as against estimating the levels immediately or less 48 hours after operation. 28 adult female albino rats of Wistar strain were used. They were fed twice a day with Guinea pellets and ...

  14. Effects of bentonite on plasma urea and creatinine of wistar albino rats.

    African Journals Online (AJOL)

    The in vivo effect of Nigerian calcium bentonite clay on wistar albino rat plasma urea and creatinine levels were investigated. The rats were fed for a period of four weeks with varying concentrations of the bentonite clay, and the urea and creatinine levels determined using spectrophotometric methods. Test results showed ...

  15. Desigualdades territoriales en México derivadas del tratado de libre comercio de América del Norte

    Directory of Open Access Journals (Sweden)

    Javier Delgadillo Maclas

    2008-04-01

    Full Text Available La instrumentación del Tratado de Libre Comercio de América del Norte (TLCAN a partir del año 1994 consolidó una etapa de libe ral ización económica iniciada en México a partir de 1982. La sistemática operación del TLCAN en los distintos sectores de la economía (incorporados a este acuerdo comercial se vio al mismo tiempo acompañada de efectos territoriales favorables en algunos casos, y de dimensiones críticas para un número importante de regiones y estados que componen la federación mexicana. Después de 14 años de su inicio, en este trabajo se analizan los procesos de reestructuración espacial desde entonces generados, las disparidades regionales asociadas al nuevo escenario internacional, y se da cuenta de las relaciones económicas que contraponen a la etapa actual del modelo neoliberal imperante con aquellas otras formas tradicionales de organización excluidas y que aún mantienen en México buena proporción de espacios socialmente marginadosThe coming into force of the North American Free Trade Agreement (NAFTA from 1994 consolidated a phase of Mexican economic liberalization that had begun in 1982. The systematic operationalization of the NAFTA in different sectors of the economy (incorporated into this commercial agreement was also accompanied by favorable spatial impacts in some cases, and unfavorable impacts for a significant number of regions and states of the Mexican federation. Fourteen years on, this article analyzes the processes of spatial restructuring that have been generated, the regional disparities associated with the new international scenario, and explains the economic relations that run in opposition to the current stage of the dominant neoliberal model, which has excluded other traditional forms of organization and has kept many areas of Mexico in a condition of social marginalization

  16. Retroauricular Approach for Targeted Cochlear Therapy Experiments in Wistar Albino Rats

    Directory of Open Access Journals (Sweden)

    Selçuk Mülazımoğlu

    2017-06-01

    Full Text Available Background: As the idea of stem cell technology in the treatment of sensorial hearing loss has emerged over the past decades, the need for in vivo models for related experiments has become explicit. One of the most common experimental models for inner ear stem cell delivery experiments is the Wistar albino rat. Aims: To investigate the surgical anatomy of the temporal bone of the Wistar albino rat with respect to the dissection steps, operative techniques and potential pitfalls of surgery. Study Design: Animal experimentation. Methods: Adult Wistar albino rats were operated on via the retroauricular approach under an operation microscope. The anatomy of the temporal bone, the surgical route to the temporal bulla and the inner ear were investigated. Technical details of surgical steps, complications and potential pitfalls during the surgery were noted. Results: The study group consisted of 40 adult Wistar albino rats. The mean times to reach the bulla and to achieve cochleostomy were 4.3 (2-13 min and 7.5 min (3.5-22 min, respectively. The mean width of the facial nerve was 0.84 mm (0.42-1.25 mm. The stapedial artery lay nearly perpendicular to the course of the facial nerve (88-93 °C. There were three major complications: two large cochleostomies and one massive bleed from the stapedial artery. Conclusion: The facial nerve was the key anatomical landmark in locating the bulla. By retrograde tracing of the facial nerve, it was possible to find the bulla ventral (inferior to the main trunk. The facial nerve trunk was the upper limit when drilling the bulla. By dissecting the main trunk of the facial nerve and retracting cranially, a large drilling space could be achieved. Our results suggest that the retroauricular approach is an effective, feasible route for inner ear drug delivery experiments in Wistar albino rats

  17. O tratado sobre a luz de Huygens: comentários

    Directory of Open Access Journals (Sweden)

    Sonia Krapas

    2011-01-01

    Full Text Available http://dx.doi.org/10.5007/2175-7941.2011v28n1p123 Huygens é conhecido no ensino introdutório de Física por dar conta da refração segundo um modelo ondulatório. Livros didáticos lhe rendem homenagens atribuindo seu nome a um princípio, mas em sua obra máxima, Tratado sobre a luz, é possível se ver muito mais: sua inventividade na defesa de um modelo ondulatório para a luz como alternativo ao modelo corpuscular. Neste trabalho, tenta-se evidenciar o raciocínio de Huygens, mostrando que, apesar de ter sido publicada há mais de trezentos anos, a obra está escrita numa linguagem relativamente acessível.

  18. South Pacific Nuclear Free Zone Treaty; Tratado Sobre La Zona Desnuclearizada Del Pacifico Sur

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-02-15

    On 6 August 1985 the South Pacific Forum, a body comprising the independent and self-governing countries of the South Pacific (Australia, the Cook Islands, Fiji, Kiribati, Nauru, New Zealand, Niue, Papua New Guinea, the Solomon Islands, Tonga, Tuvalu, Vanuatu and Western Samoa), endorsed the text of the South Pacific Nuclear Free Zone Treaty and opened it for signature [Spanish] El 6 de agosto de 1985 el Foro del Pacifico Sur, organo compuesto por los paises independientes y autonomos del Pacifico Sur (Australia, Fiji, Islas Cook, Islas Salomon, Kiribati, Nauru, Niue, Nueva Zelandia, Papua Nueva Guinea, Samoa Occidental, Tonga, Tuvalu, y Vanuatu), aprobo el texto del Tratado sobre la Zona Desnuclearizada del Pacifico-Sur y lo abrio a la firma.

  19. Migración laboral México-Estados Unidos a veinte años del Tratado de Libre Comercio de América del Norte

    Directory of Open Access Journals (Sweden)

    Ana María Aragonés Castañer

    2015-01-01

    Full Text Available El fenómeno de la migración internacional de trabajadores está íntimamente relacionado con las desigualdades y las asimetrías del sistema capitalista y supone, además, la transferencia de plusvalía de los centros menos desarrollados hacia los polos industrializados o desarrollados. Si los países expulsores de migrantes se han ca-racterizado por aplicar políticas económicas que han ampliado los niveles de desempleo, la pau-perización de las condiciones laborales, la falta de apoyo al campo y el incremento del trabajo informal, en los países receptores los migrantes tienen una funcionalidad que se expresa en la diferencia existente entre el costo laboral unitario de los migrantes respecto de los trabajadores nativos. En este marco, el Tratado de Libre Co-mercio de América del Norte (1994 produjo una mayor subordinación económica de México hacia Estados Unidos y un crecimiento extraor-dinario de los flujos migratorios, en particular de la migración indocumentada, para los que no hubo ninguna protección ni cobertura legal.

  20. LA RELACIÓN ENTRE TRATADOS DE INVERSIÓN Y CONVENIOS DE DOBLE TRIBUTACIÓN: el caso chileno

    Directory of Open Access Journals (Sweden)

    Rodrigo Polanco Lazo

    Full Text Available El presente artículo examina las relaciones entre los tratados de inversión y los tratados de doble tributación, considerando que, en la actual evolución de ambos tipos de acuerdos, sus disposiciones pueden presentar superposiciones en aspectos tales como estándares de protección, transparencia, trato nacional, cláusula de la nación más favorecida, expropiación y transferencias de capital. Tomando el ejemplo de los tratados suscritos por Chile, en este trabajo se examinan las consecuencias de las trasposiciones de ambos acuerdos, desde el punto de vista de sus mecanismos de solución de controversias, como en lo referido a los conflictos de jerarquía normativa entre esos dos tipos de tratados. Asimismo, se efectúa un análisis sobre iniciativas de tipo multilateral que afectan a ambas categorías de acuerdos como el Base Erosion and Profit Shifting (BEPS.

  1. Studies on the hypolipidemic effects of Coconut oil when blended with Tiger nut oil and fed to albino rats

    Directory of Open Access Journals (Sweden)

    El-Anany, A. M.

    2012-09-01

    Full Text Available Hyperlipidemia is a predominant risk factor for atherosclerosis and associated cardiovascular diseases (CVD. The international guidelines issued by the World Health Organization recommend a reduction in dietary saturated fat and cholesterol intake as a means to prevent hypercholesterolemia and CVD. The main objective of the current investigation was to evaluate the effects of feeding blended oils consisting of coconut oil (CNO with different proportions of Tiger nut oil (TNO on serum lipid levels in Albino rats. GLC analysis was performed to illustrate the fatty acid composition of the blended oils. Blended oils were obtained by mixing tiger nut oil with coconut oil at the volume ratios of 100:0, 70:30, 50:50, 25:75, 10:90 and 0:100. Fifty-six male albino rats were randomly divided into 7 groups of 8 rats each according to the oil type. The blended oils were fed to rats for a period of up to 10 weeks. Total cholesterol (T-Ch, high-density lipoprotein cholesterol (HDL-Ch, low-density lipoprotein cholesterol (LDL-Ch, and triglycerides (TG, were determined. The atherogenic Index (AI was calculated. The results showed that non-significant changes in all nutritional parameters were observed between the control group and the rats fed with the tested oils. The results also indicate that coconut oil had 86% saturated fatty acids. On TNO contains 66% oleic acid. Therefore, blending coconut oil with tiger nut oil can reduce the proportions of saturated to unsaturated fatty acids in CNO. The rats that were fed blended oils showed significantly reduced levels of serum cholesterol as compared to those fed CNO. The HDL levels were marginally enhanced in the rats that were fed blended oils. The total cholesterol and LDL cholesterol levels were controlled when TNO/CNO proportions varied between 25/75 and 70/30. This was reflected in the calculation of the atherogenic index. Similar changes were observed with serum triglyceride levels.

    La hiperlipidemia

  2. Os Tratados de Polícia, fundadores da moderna saúde pública (1707-1856 Los Tratados de Policía, fundadores de la salud pública moderna (1707-1856 Treatises on Medical Police, founders of modern public health (1707-1856

    Directory of Open Access Journals (Sweden)

    Carlos Lousada Subtil

    2012-07-01

    Full Text Available A participação dos enfermeiros no movimento higienista é relativamente recente em relação aos momentos fundadores da moderna saúde pública, a que nos vamos referir. Para o enfermeiro de saúde pública contemporâneo é fundamental, no âmbito das suas atribuições e competências, analisar esses momentos à luz dum quadro conceptual que lhe permita esclarecer-se e estruturar a sua identidade profissional na construção do presente e no delinear do futuro. É objetivo deste trabalho fazer uma breve apresentação de alguns estudos sobre o tema e, sobretudo, analisar e discutir o «Tratado de Conservação da Saúde dos Povos», de Ribeiro Sanches (1756 e o «Tratado de Polícia Médica», de Freitas Soares (1818 que refletem os princípios da ciência de Polícia contidos na obra de Nicolas Delamare (1707, com recurso à metodologia de investigação histórica foucauniana. Aquelas obras ilustram bem a lenta passagem do modelo de governação corporativo para o estadualista, que se iniciou nos finais do Antigo Regime, e prosseguiu, com avanços e recuos, ao longo da monarquia constitucional inaugurada pela revolução de 1820.La participación de los enfermeros en el movimiento higienista es relativamente reciente con respecto a los momentos fundadores de la salud pública moderna a la cual vamos a referirnos. Para el enfermero actual de salud pública es fundamental, dentro del ámbito de sus atribuciones y competencias, analizar dichos movimientos a la luz de un marco conceptual que le permita aclarar y estructurar su identidad profesional en su construcción del presente y en el delinear de su futuro. El objetivo de este trabajo es realizar una breve presentación de algunos de los estudios sobre el tema y, sobre todo, analizar y discutir el «Tratado de Conservação da Saúde dos Povos», de Ribeiro Sanches (1756 y el «Tratado de Polícia Médica», de Freitas Soares (1818, que recogen los principios de la ciencia de Pol

  3. Observatorio de los tratados de libre Comercio en Colombia: oportunidades de exportación para Colombia a los países miembros de la comunidad Andina (Perú, Bolivia, Ecuador)

    OpenAIRE

    Páez Murcia, Jenniffer Adriana; Parada Suárez, Karen Juliana

    2015-01-01

    Hoy en día, gracias a la globalización y a los tratados de libre comercio que a través de los años Colombia ha logrado firmar, el país ha conseguido nuevas oportunidades de mercado, y así mismo, ha podido identificar grandes apuestas a futuro,de tal manera que los productos colombianos lleguen a más países y compitan en un mercado donde grandes proveedores mundiales tratan de posicionarse. En este documento se quiere mostrar la relación comercial que mantiene el país Colombiano con los demás ...

  4. Ascorbic acid treatment elevates follicle stimulating hormone and testosterone plasma levels and enhances sperm quality in albino Wistar rats

    OpenAIRE

    Okon, Uduak Akpan; Utuk, Ikponoabasi Ibanga

    2016-01-01

    Background: Infertility issues have been linked to the effect of oxidative reaction in the reproductive system. This study evaluated the effect of ascorbic acid, on fertility parameters of male albino Wistar rats was studied. Materials and Methods: Eighteen albino Wistar rats weighed between 178 g and 241 g were used, randomly assigned into three groups. Group 1 was the control group; oral gavaged 5 ml of distilled water; Groups 2 and 3 were administered medium dose (250 mg/kg) and high dose ...

  5. Assessment of anti-nociceptive efficacy of costus speciosus rhizome in swiss albino mice.

    Science.gov (United States)

    Bhattacharya, Sanjib; Nagaich, Upendra

    2010-01-01

    Present study attempts to evaluate the anti-nociceptive activity of the aqueous and ethanol extracts of Costus speciosus rhizome (CPA and CPE) in Swiss albino mice. The maceration extracts were evaluated for anti-nociceptive activity by acetic acid-induced writhing and tail flick method in mice. The anti-nociceptive screening revealed significant peripheral anti-nociceptive actions of both extracts against acetic acid induced writhing in mice. Aqueous extract (CPA) significantly inhibited writhes at the dose of 75 and 150 mg/kg body weight, while ethanol extract (CPE) produced significant protection at the dose of 150 mg/kg body weight. However, in tail flick method only the ethanol extract (CPE) showed significant central analgesic action, while aqueous extract was totally ineffective. The present investigation demonstrates that the rhizome extracts of C. speciosus exhibited significant anti-nociceptive effects in Swiss albino mice.

  6. Assessment of anti-nociceptive efficacy of Costus Speciosus rhizome in swiss albino mice

    Directory of Open Access Journals (Sweden)

    Sanjib Bhattacharya

    2010-01-01

    Full Text Available Present study attempts to evaluate the anti-nociceptive activity of the aqueous and ethanol extracts of Costus speciosus rhizome (CPA and CPE in Swiss albino mice. The maceration extracts were evaluated for anti-nociceptive activity by acetic acid-induced writhing and tail flick method in mice. The anti-nociceptive screening revealed significant peripheral anti-nociceptive actions of both extracts against acetic acid induced writhing in mice. Aqueous extract (CPA significantly inhibited writhes at the dose of 75 and 150 mg/kg body weight, while ethanol extract (CPE produced significant protection at the dose of 150 mg/kg body weight. However, in tail flick method only the ethanol extract (CPE showed significant central analgesic action, while aqueous extract was totally ineffective. The present investigation demonstrates that the rhizome extracts of C. speciosus exhibited significant anti-nociceptive effects in Swiss albino mice.

  7. Attenuation of N-nitrosodimethylamine induced hepatotoxicity by Operculina turpethum in Swiss Albino mice

    Science.gov (United States)

    Sharma, Veena; Singh, Manu

    2014-01-01

    Objective(s): To appraise the antihepatotoxic efficacy of ethanolic extract of Operculum turpethum root on the liver of Swiss albino mice. Materials and Methods: Hepatic fibrosis was induced in adult male albino mice through intraperitoneal administrations of N-nitrosodimethylamine (NDMA) at the concentration of 10 mg/kg body weight. The liver toxicity and therapeutic effect of the plant ethanolic extract was assessed by the analysis of liver marker enzymes and antioxidant enzymes and liver histopathological studies. Results: Hepatotoxicity was manifested by significantly decreased (PNDMA induced toxicity which was also supported by histopathological studies of the liver. Conclusion: O. turpethum manifested therapeutic effects by significantly restoring the enzymatic levels and reducing the hepatic damage in mice. This work intends to aid researchers in the study of natural products which could be useful in the treatment of liver diseases including cancer. PMID:24592311

  8. Implantación de la moneda única europea en aplicación del Tratado de Maastricht y la crisis del sistema monetario europeo durante el periodo de convergencia económica : factores relevantes para la estabilidad cambiaria y análisis positivo del proceso de uni

    OpenAIRE

    Gomez Ortiz, Miguel Ángel

    1993-01-01

    Se analizan las variables relevantes del proceso de unión monetaria así como el funcionamiento del Sistema Monetario Europeo y el contenido del Tratado de Maastricht. Con esta base se plantea la preferencia de una moneda única como el mecanismo más idóneo para lograr optimizar el proceso de unión económica y monetaria de la Comunidad Europea, realizándose un análisis histórico e institucional tanto de la evolución monetario-financiera de la Comunidad como del mecanismo de cambios e intervenci...

  9. Prolactin effect on the insulin content of albino rats in different physiological states

    International Nuclear Information System (INIS)

    Megahed, Y.M.; Abdel-Wahab, M.F.; El-Mougi, S.M.; El-Sayed, F.B.; Kuwait Univ.)

    1980-01-01

    The metabolic action of prolactin on insulin levels in plasma and pancreas has been studied. Prolactin was injected in a single dose or single daily doses on 4 successive days into albino rats in six different physiological states. Insulin was determined by radioimmunoassay using 125 I insulin. From the results it is concluded that prolactin injected i.p. influences the output of insulin and stimulates the pancreas to secrete insulin into the plasma. (author)

  10. Effect of nigella sativa seeds extract on serum c-reactive protein in albino rats

    International Nuclear Information System (INIS)

    Bashir, M.U.; Qureshi, H.

    2014-01-01

    C-reactive protein (CRP) is an acute phase protein. It predicts future risk of cardiovascular diseases. Different medicinal plants and their active ingredients possess the ability to reduce serum CRP levels and hence inflammatory disorders and cardiovascular diseases. In our study, ethanolic extract of Nigella sativa seeds was evaluated in albino rats for its possible effect on serum CRP levels. Objective: The objective of this study was to determine the effect of ethanolic extract of Nigella sativa seeds on an acute inflammatory biomarker/mediator, C-reactive protein (CRP) in albino rats. Study Design: Randomized controlled trial (RCT). Place and Duration of Study: Physiology Department, Services Institute of Medical Sciences (SIMS), Lahore; from September to November, 2009. Subjects and Methods: The study was carried out on 90 male albino rats. Five percent (5%) formalin in a dose of 50 meu1 was injected into sub-plantar surface of right hind paw of each rat to produce inflammation. The rats were randomly divided into three groups of thirty each. Group A was given normal saline (control); group B was given Nigella sativa seed extract; and group C received diclofenac sodium, as a reference drug. CRP levels in each group were measured from blood samples taken 25 hours after giving formalin. Results: The ethanolic extract of Nigella sativa seeds, given intraperitoneally, caused highly significant (p<0.001) reduction in serum CRP levels as compared to control group. The reduction in CRP levels by ethanolic extract of Nigella sativa was also significantly (p<0.05) more than that produced by diclofenac sodium. Conclusion: Our results suggest that Nigella sativa possesses ability to reduce serum CRP levels significantly, after production of artificial inflammation, in albino rats. (author)

  11. Delayed nootropic effects of arginine vasopressin after early postnatal chronic administration to albino rat pups.

    Science.gov (United States)

    Kim, P A; Voskresenskaya, O G; Kamensky, A A

    2009-06-01

    Intranasal administration of arginine vasopressin (10 microg/kg) to albino rat pups had a strong nootropic effect during training with positive and negative reinforcement. This effect was different in animals of various age groups: training with positive reinforcement was improved in "adolescent" rats and pubertal animals, while during training with negative reinforcement, the nootropic effect of the peptide was more prolonged and persisted also in adult animals.

  12. PHARMACOLOGICAL VALIDATION OF Musa paradisiaca BHASMA FOR ANTIULCER ACTIVITY IN ALBINO RATS - A PRELIMINARY STUDY.

    Science.gov (United States)

    Vadivelan, R; Elango, K; Suresh, B; Ramesh, B R

    2006-01-01

    Siddha system of medicine is one of the ancient systems of medicine in India. According to Siddhars, peptic ulcer is known as Valigunmam with its signs and symptoms as detailed in Siddha literature matching modern terminology of peptic ulcer. Bhasma refers to calcinated metals and minerals. During this study the Bhasma of Musa paradisiaca Linn, is prepared and evaluated for its antiulcer effect in albino wistar rats which could not be attempted by researchers earlier.

  13. Evaluation of Musa (Paradisiaca Linn. cultivar)--"Puttubale" stem juice for antilithiatic activity in albino rats.

    Science.gov (United States)

    Prasad, K V; Bharathi, K; Srinivasan, K K

    1993-10-01

    The fresh juice of Musa stem (Puttubale) was tested for its antilithiatic activity. Zinc discs were implanted in the urinary bladder of albino rats to induce urolithiasis. The stones formed were mainly of magnesium ammonium phosphate with traces of calcium oxalate. Musa stem juice (3 mL/rat/day orally) was found to be effective in reducing the formation and also in dissolving the pre-formed stones.

  14. PHARMACOLOGICAL VALIDATION OF Musa paradisiaca BHASMA FOR ANTIULCER ACTIVITY IN ALBINO RATS – A PRELIMINARY STUDY

    Science.gov (United States)

    Vadivelan, R.; Elango, K.; Suresh, B.; Ramesh, B. R.

    2006-01-01

    Siddha system of medicine is one of the ancient systems of medicine in India. According to Siddhars, peptic ulcer is known as Valigunmam with its signs and symptoms as detailed in Siddha literature matching modern terminology of peptic ulcer. Bhasma refers to calcinated metals and minerals. During this study the Bhasma of Musa paradisiaca Linn, is prepared and evaluated for its antiulcer effect in albino wistar rats which could not be attempted by researchers earlier. PMID:22557209

  15. Analysis of inorganic elements in blood of albino rabbit using NAA

    International Nuclear Information System (INIS)

    Metairon, Sabrina; Zamboni, Cibele B.; Medeiros, Ilca M.M.A.

    2009-01-01

    In this work Br, Cl, K and Na concentrations in albino rabbit blood were determinate using NAA. They are the first indicative interval for reference values in whole blood and they could be used for checking the clinical status of this specie when it will be used was animal model. The results when compared with human whole blood estimation suggest compatibility for Br, Cl and K considering 95% of confidence interval but, for Na the levels are altered, suggesting physiologic differences. (author)

  16. Comparison of anti-inflammatory activity of nigella sativa and diclofenac sodium in albino rats

    International Nuclear Information System (INIS)

    Bashir, M.U.; Qureshi, H.J.; Saleem, T.

    2015-01-01

    Background: Nigella sativa or Kalonji is a naturally occurring plant in Pakistan and other countries which possesses a wide range of medicinal properties, the anti-inflammatory property being one of these. Diclofenac sodium is a commonly used anti-inflammatory drug. The purpose of this study was to compare the anti-inflammatory effect of ethanolic extract of Nigella sativa seeds with that of diclofenac sodium in albino rats. Method: This laboratory randomized controlled trial (RCT) was conducted in the Physiology Department, Services Institute of Medical Sciences (SIMS), Lahore. The study was carried out on 90 male albino rats. Five percent formalin in a dose of 50 meu was injected into sub-plantar surface of right hind paw of each rat to produce inflammation. The rats were randomly divided into three groups of thirty each. Group A was given normal saline (control); group B was given Nigella sativa seed extract; and group C received diclofenac sodium, as a reference drug. Increase in paw diameter, and total and differential leukocyte counts were measured as markers of inflammation. Results: Nigella sativa seeds extract caused significant (p<0.05) reduction in the paw inflammatory response in albino rats. The effect was longer in duration than the effect caused by diclofenac sodium; however, the extract was comparatively less potent than diclofenac sodium. The extract had no significant effect (p>0.05) on the total or differential leukocyte counts. Conclusion: Our results suggest that ethanolic extract of Nigella sativa seeds possesses potent anti-inflammatory effect, in albino rats however, this effect is comparatively less but prolonged than that produced by diclofenac sodium. (author)

  17. Beliefs and practices concerning twins, hermaphrodites, and albinos among the Bamana and Maninka of Mali.

    Science.gov (United States)

    Imperato, Gavin H; Imperato, Pascal James

    2006-06-01

    The Bamana and Maninka of Mali greatly value twins, and have elaborated a range of cultural beliefs and practices to assure their survival. Rates of twinning among these two ethnic groups average from 15.2/1000 to 17.9/1000 births compared to 10.5/1000 births (without assisted reproduction) in the United States and Great Britain. Twins (flaniw) are regarded as extraordinary beings with unusual powers, and as a gift from the supreme deity. A small altar (sinzin) is maintained in the home of twins, and periodic sacrifices of chicken blood, kola nuts, millet paste and millet beer regularly made to assure their protection. Albinos (yéfeguéw) and true and pseudo-hermaphrodites (tyéténousotéw) are also considered twin beings. However, they are believed to be the result of aberrant parental social behavior. The Bamana and Maninka believe that all four groups (twins, albinos, hermaphrodites, and pseudo-harmaphrodites) are closely linked to Faro, an androgynous supernatural being who provides equilibrium in the world. Faro is the original albino and hermaphrodite who gave birth to the first pair of twins after self-impregnation. Whenever a twin dies, a small wooden statue is sculpted called a flanitokélé (twin that remains). This commemorative figure is kept close to the surviving twin, reflecting a belief in the inseparability of twins. Eventually, the surviving twin takes responsibility for the figure. When a surviving twin marries, another figure is often sculpted in the opposite sex from the deceased twin, and placed with the original sculpture. Such commemorative sculptures are not created upon the death of those who are albinos, hermaphrodites, or pseudo-hermaphrodites. In recent years, transformational belief patterns have evolved as increasing numbers of Bamana and Maninka embrace Islam. Traditional beliefs are often given Islamic myths of origin. However, even in this Islamic context, many practices that assure twin survival are maintained.

  18. Tartrazine induced changes in physiological and biochemical parameters in Swiss albino mice, Mus musculus

    OpenAIRE

    Arefin, Sayema; Hossain, Mohammad Salim; Akter Neshe, Shamme; Rashid, Md. Mamun Or; Amin, Mohammad Tohidul; Hussain, Md. Saddam

    2017-01-01

    Now-a-days synthetic food dyes are being used most commonly as food colorant in confectionaries, drugs and cosmetics. Present study was designed to evaluate the toxic effect of tartrazine, a widely used azo dye, on Swiss Albino mice. Experimental animals were treated with tested dye at a dose level 200mg/kg & 400mg/kg body weight along with normal diet. Various physiological and biochemical parameters were assessed to study the toxic effect of tartrazine. Our study rev...

  19. Protective Effect of Rosemary (Rosmarinus Officinalis) Extract on Naphthalene Induced Nephrotoxicity in Adult Male Albino Rat

    OpenAIRE

    Neveen M. El-Sherif; Noha Mohy Issa

    2015-01-01

    Background: Naphthalene (NA) is a common environmental contaminant and is abundant in tobacco smoke. Rosemary (Rosmarinus officinalis) is a herb commonly used as a spice and flavoring agents in food processing and is useful in the treatment of many diseases. Aim of the work: To study the nephrotoxicity of NA and to evaluate the possible protective role of rosemary extract in adult male albino rat. Materials and Methods: 25 animals were divided into three groups: Group I (Control group), G...

  20. Comportamiento del asma bronquial en adolescentes tratados en el Policlínico Universitario "Ana Betancourt" Course of bronchial asthma in adolescents seen in "Ana Betancourt" University Polyclinic

    Directory of Open Access Journals (Sweden)

    Tatiana de la Vega Pazitková

    2010-03-01

    Full Text Available Introducción: el asma infantil representa una entidad que aún no ha logrado ser bien definida y delimitada, lo que establece variadas interpretaciones de su epidemiología, diagnóstico y, consecuentemente de su tratamiento. Objetivos: estimar la prevalencia global de asma en adolescentes tratados en consultorios médicos de familia del Policlínico Universitario "Ana Betancourt". Métodos: se realizó un estudio descriptivo, de corte transversal, que incluyó a 81 adolescentes de ambos sexos con edades entre 11 y 18 años, pertenecientes a dos consultorios médicos de familia del Grupo Básico de Trabajo No. 2, del Policlínico Universitario "Ana Betancourt", del municipio Playa, en el período comprendido entre enero de 2006 y enero de 2007. Como herramienta de trabajo se utilizó el cuestionario: The International Study of Asthma and Allergies in Childhood, instrumento validado internacionalmente. Resultados: la cifra total de asmáticos ascendió a 52 adolescentes con un discreto predominio del sexo masculino y de los casos ligeros de la enfermedad, para una prevalencia global de 64,1 %. Se encontró un subregistro de 20,9 %. Conclusiones: en ambos consultorios se constata una elevada prevalencia de asma bronquial en la población de adolescentes con mayor afectación en los varones. Los pacientes exhiben mayoritariamente las formas ligeras de la enfermedad. Se encuentra un importante subregistro para el asma bronquial en los adolescentes tratados en el Policlínico Universitario "Ana Betancourt"Introduction: the bronchial asthma is a even defined entity establishing some interpretations of its epidemiology, diagnosis and consequently of its treatment. Objectives: to estimate the global prevalence of asthma in adolescents seen in family medical consulting rooms from "Ana Betancourt" University Polyclinic. Methods: a descriptive, cross-sectional study was conducted including 81 adolescents of both sexes aged between 11 and 18 from family

  1. Histological review of skin cancers in African Albinos: a 10-year retrospective review

    International Nuclear Information System (INIS)

    Kiprono, Samson Kimaiyo; Chaula, Baraka Michael; Beltraminelli, Helmut

    2014-01-01

    Skin cancer is rare among Africans and albinism is an established risk for skin cancer in this population. Ultraviolet radiation is highest at the equator and African albinos living close to the equator have the highest risk of developing skin cancers. This was a retrospective study that involved histological review of all specimens with skin cancers from African albinos submitted to The Regional Dermatology Training Center in Moshi, Tanzania from 2002 to 2011. A total of 134 biopsies from 86 patients with a male to female ratio of 1:1 were reviewed. Head and neck was the commonest (n = 75, 56.0%) site affected by skin cancers. Squamous cell carcinoma (SCC) was more common than basal cell carcinoma (BCC) with a ratio of 1.2:1. Only one Acral lentiginous melanoma was reported. Majority (55.6%) of SCC were well differentiated while nodular BCC (75%) was the most common type of BCC. Squamous cell carcinoma is more common than basal cell carcinoma in African albinos

  2. COMPARISON OF ANTI-INFLAMMATORY ACTIVITY OF NIGELLA SATIVA AND DICLOFENAC SODIUM IN ALBINO RATS.

    Science.gov (United States)

    Bashir, Muhammad Usman; Qureshi, Hamid Javaid; Saleem, Tahira

    2015-01-01

    Nigella sativa or "Kalonji" is a naturally occurring plant in Pakistan and other countries which possesses a wide range of medicinal properties, the anti-inflammatory property being one of these. Diclofenac sodium is a commonly used anti-inflammatory drug. The purpose of this study was to compare the anti-inflammatory effect of ethanolic extract of Nigella sativa seeds with that of diclofenac sodium in albino rats. This laboratory randomized controlled trial (RCT) was conducted in the Physiology Department, Services Institute of Medical Sciences (SIMS), Lahore. The study was carried out on 90 male albino rats. Five percent formalin in a dose of 50 µl was injected into sub-plantar surface of right hind paw of each rat to produce inflammation. The rats were randomly divided into three groups of thirty each. Group A was given normal saline (control); group B was given Nigella sativa seed extract; and group C received diclofenac sodium, as a reference drug. Increase in paw diameter, and total and differential leukocyte counts were measured as markers of inflammation. Nigella sativa seeds extract caused significant (pdiclofenac sodium; however, the extract was comparatively less potent than diclofenac sodium. The extract had no significant effect (p>0.05) on the total or differential leukocyte counts. Our results suggest that ethanolic extract of Nigella sativa seeds possesses potent anti-inflammatory effect, in albino rats however, this effect is comparatively less but prolonged than that produced by diclofenac sodium.

  3. Effect of Variable Doses of Zinc Oxide Nanoparticles on Male Albino Mice Behavior.

    Science.gov (United States)

    Zahra, Javeria; Iqbal, Shahid; Zahra, Kiran; Javed, Zulha; Shad, Muhammad Aslam; Akbar, Atif; Ashiq, Muhammad Naeem; Iqbal, Furhan

    2017-02-01

    Zinc oxide nanoparticles (ZnO NPs) have diverse utility these days ranging from being part of nanosensors to be ingredient of cosmetics. Present study was designed to report the effect of variable doses of ZnO NPs on selected aspects of male albino mice behavior. Nano particles were synthesized by sol-gel auto-combustion method (Data not shown here). 10 week old male albino mice were divided into four experimental groups; group A, B and C were orally supplemented with 50 (low dose), 300 (medium dose) and 600 mg/ml solvent/kg body weight (high dose) of ZnO NPs for 4 days. Group D (control) orally received 0.2 M sodium phosphate buffer (solvent for ZnO NPs) for the same duration. A series of neurological tests (Rota rod, open field, novel object and light-dark box test) were conducted in all groups and performance was compared between ZnO NPs treated and control group. Muscular functioning during rota rod test was significantly improved in all ZnO NPs treated mice as compared to control group. While no significant differences in open field, novel object and light-dark box test performance were observed when data from studied parameters of specific ZnO NPs treatment were compared with the control group indicating that applied doses of ZnO NPs did not affect the exploratory, anxiolytic behavior and object recognition capability of adult male albino mice.

  4. Ocular distribution of topically applied adrenaline in albino and pigmented rabbits

    International Nuclear Information System (INIS)

    Urtti, A.; Periviita, L.; Salminen, L.

    1984-01-01

    Systemic absorption, ocular distribution and ocular metabolism in albino and pigmented rabbit of topically applied 1% [ 3 H]1-adrenaline eye drops was studied by liquid scintillation counting and thin layer chromatography. The effect of adrenaline on the pupillary diameter was also registered. The peak plasma level of adrenaline was reached at 150 min. The corneal adrenaline metabolism was substantial, but did not vary with the rabbit strain. At 30 min after instillation, the total adrenaline concentration of pigmented iris and ciliary body exceeded that of corresponding albino tissues. At 180 min the drug concentration of the iris and ciliary body did not differ between the rabbit strains. Th time course of adrenaline induced mydriasis was equal in both rabbit strains. Since neither total adrenaline concentration at 180 min nor the time course of adrenaline induced mydriasis differed between the rabbit strains, the higher initial adrenaline uptake by pigmented tissues is not explained by pigment binding. It is proposed that the increased initial binding of adrenaline by pigmented tissues is caused by a difference between pigmented and albino tissues in the number of adrenergic neurones; this is also supported by the literature. (author)

  5. STUDY OF HEPATOPROTECTIVE ACTIVITY OF EMBLICA OFFICINALIS (AMLA IN ALBINO RATS

    Directory of Open Access Journals (Sweden)

    Chinmoyee Deori

    2017-07-01

    Full Text Available BACKGROUND The study has been undertaken to evaluate the hepatoprotective activity of fruits extract of Emblica officinalis on carbon tetrachloride-induced hepatotoxicity on Albino rats. MATERIALS AND METHODS The present study was conducted in the Department of Pharmacology. The required amount of fresh fruits of Emblica officinalis were collected and prepared by percolation method using 90% ethyl alcohol. Oral toxicity test was performed as per OECD 423 guidelines. Liver damage was induced in Albino rats with carbon tetrachloride at the dose of 0.5 mL/kg/body weight subcutaneously. All the animals used for the experiment were kept under observation for daily food intake and body weight were measured after 7 days. The drugs were administered to the animals in the dose of 200 mg/kg/body weights by means of an intragastric feeding tube. The experiment was carried out for the period of 14 days. RESULTS The study was carried out with an attempt to evaluate the hepatoprotective activity of Emblica officinalis in carbon tetrachloride-induced hepatic injury in albino rats and was compared with standard drug Silymarin. The statistical significance between groups was analysed using one way ANOVA followed by Dunnett’s test. The significance was expressed by ‘p’ values as mentioned in the tables. P value of <0.05 was considered significant. CONCLUSION From this study, it can be seen that Emblica officinalis has significant hepatoprotective activity in rats with CCL4-induced liver injury.

  6. Nuestra Experiencia con la técnica de Barcat y Godart en el Torticolis Muscular Congénito

    OpenAIRE

    Remartínez Rivares, José María; Latorre Sahún, A.; Castiella Muruzabal, Tomás; Aznar Aznarez, J. Mª; Seral Iñigo, Fernando

    1990-01-01

    Los autores exponen los resultados obtenidos en diez casos de T.M.C. tratados quirúrgicamente con la técnica de Barcat y Godard, tanto estéticos como funcionales. Se analizan los parámetros de sexo, edad de intervención, lado afectado, tipo de parto, anomalías asociadas, y presencia de asimetría facial, movilidad craneal, pérdida de relieve muscular y aparición de bandas laterales postoperatorias. Estos resultados son comparados con los otros autores, mostrándose superiores....

  7. La inclusión en las clases de educación física con juegos sensibilizadores

    OpenAIRE

    Navarro Pérez, Micaela E.

    2017-01-01

    [58 p.] il. 1 CD La presente Investigación se dispone a fin de mejorar la inclusión de niños con discapacidad, en grados de escuelas comunes, trabajando directamente sobre los niños convencionales de la clase; a través de los Juegos Sensibilizadores. La misma se encuentra enmarcada dentro del tipo de investigación básica descriptiva, debido a que el tema tratado está sustentado por un marco teórico, y se caracteriza por la situación real de trabajo con los niños convencionales. Esta ...

  8. Sífilis secundaria en un paciente viviendo con VIH

    Directory of Open Access Journals (Sweden)

    Mauricio La Rosa

    2007-07-01

    Full Text Available Se presenta el caso de un paciente varón de 31 años, con diagnóstico de infección por el virus de inmunodeficiencia humana (VIH sin tratamiento antirretroviral, presentó lesiones ulcerativas en la región genital que luego progresaron por todo el cuerpo, se le diagnosticó sífilis secundaria. Fue tratado con penicilina benzatínica, con lo cual las lesiones desaparecieron. Se discute las pruebas diagnósticas realizadas y la terapéutica empleada. La coinfección por Treponema pallidum y por el VIH está presente en la población general y en especial en poblaciones de riesgo, como los hombres que tienen sexo con hombres y clientes de trabajadoras sexuales, esta situación puede afectar la presentación inicial así como el curso de la enfermedad.

  9. El individuo ante la biopolítica: Tratado de Libre Comercio Colombia-EE.UU.

    Directory of Open Access Journals (Sweden)

    Martha Isabel Gómez Lee

    2009-11-01

    Full Text Available El problema de las patentes de biotecnología puede ser visto como un asunto de política de ciencia y tecnología, en la que el contexto de la globalización y de la sociedad del conocimiento cruza la política de la vida o biopolítica. En los Estados Unidos se considera un asunto de política pública del conocimiento, mientras que en Colombia es una cuestión de política social y ambiental. Los ciudadanos colombianos tienen mucho que decir y controlar en la revolución biotecnológica y comercial que redimensiona la extracción de renta de la tierra y reconfigura a la biodiversidad colombiana como nueva renta de germoplasma global. Los individuos están llamados a actuar de manera creativa en tres dimensiones: como agentes políticos y fuente de razones y acciones políticas, como objetivo último de las decisiones y las acciones de la biopolítica y como interfase entre las políticas públicas globales y las sociales. En esta última dimensión, el individuo colombiano es un actor político fundamental en las negociaciones del Tratado de Libre Comercio entre Estados Unidos y Colombia por ser él un actor activo de la sociedad civil en defensa de la vida.

  10. Voz e qualidade de vida de pacientes tratados de câncer avançado de laringe

    OpenAIRE

    Vaneli de Cassia Colombo Rossi

    2013-01-01

    Resumo: OBJETIVO: Avaliar qualidade de vida e voz de pacientes tratados de câncer avançado de laringe por laringectomia total ou quimioradioterapia exclusiva com preservação de órgão. MATERIAL E MÉTODOS: 30 pacientes tratados de câncer avançado de laringe livres da doença há pelo menos quatro anos: dez laringectomizados totais sem produção de voz esofágica (SVE); dez laringectomizados totais com voz traqueoesofágica (VTE) e dez com voz laríngea. A qualidade de vida foi mensurada pelos protoco...

  11. Legitimidad y finalidad de los capítulos de propiedad intelectual en los tratados de libre comercio (TLC

    Directory of Open Access Journals (Sweden)

    Susy Frankel

    2011-11-01

    Full Text Available Una visión analítica de la realidad actual permite apreciar un auge de los Tratados de Libre Comercio, mientras se presenta un estancamiento en las negociaciones multilaterales de comercio. Si bien la negociación de los TLC no se limita a los países desarrollados, los negociados por los países en desarrollo no tienden a contemplar mejoras en los estándares de propiedad intelectual. Algunos de los capítulos relativos a la propiedad intelectual incluidos en los Tratados de Libre Comercio simplemente reafirman los estándares del acuerdo sobre los ADPIC, mientras que otros se orientan a ampliar el cubrimiento y alcance de los derechos internacionales de propiedad intelectual. El presente artículo se concentra en estudiar la legitimidad y la finalidad de los capítulos de propiedad intelectual en los Tratados de Libre Comercio, así como la relación entre los capítulos sobre propiedad intelectual y el sistema multilateral de la Organización Mundial del Comercio (OMC que facilita los TLC y los límites racionales de la propiedad intelectual en el contexto comercial.

  12. Eficacia del extracto fluido de Vimang® en el tratamiento de pacientes con alveolitis

    Directory of Open Access Journals (Sweden)

    Yolanda Del Toro Gámez

    2014-09-01

    Full Text Available Se realizó un ensayo clínico de fase III en 118 pacientes con alveolitis, atendidos en la consulta estomatológica del Hospital General Docente "Dr. Juan Bruno Zayas Alfonso" de Santiago de Cuba, para evaluar la eficacia del extracto fluido de Vimang® en el tratamiento de ellos. La muestra se dividió en 2 grupos (experimental y control, distribuidos aleatoriamente; los integrantes del primero, tratados con el mencionado extracto; y los del segundo, con Alvogyl. Los resultados del estudio fueron validados mediante el estadígrafo de Ji al cuadrado. Se concluye que el extracto fluido de Vimang® fue eficaz para eliminar la alveolitis en menor tiempo y sin reacciones adversas, por lo cual se recomendó generalizar su uso

  13. Búsquedas web con información de contexto y anotaciones sociales

    OpenAIRE

    Tolosa, Gabriel Hernán; Bordignon, Fernando Raúl Alfredo

    2008-01-01

    Una de las tareas más comunes que realizan los usuarios en la Web es la búsqueda de información utilizando motores de búsqueda tradicionales. Generalmente, éstas se basan en un conjunto de términos que son tratados fuera de contexto alguno. La incorporación de información contextual permite obtener resultados más precisos y puede ser presentada al sistema de formas diferentes. Una fuente posible son los sistemas basados en “anotaciones sociales”, los cuales se enriquecen con la participación ...

  14. Osteosíntesis mini-invasiva con placas bloqueadas en fracturas metafisarias distales de tibia. Resultados clínico-funcionales. [Minimally invasive plate osteosynthesis in distal metaphyseal fractures of tibia. Comparison of results between fractures AO 43A and AO 43C.

    OpenAIRE

    Juan Manuel Yañez Arauz; Ignacio Arzac Ulla; Javier Del Vecchio; Andres Eksarho; Leandro Civetta; Rodrigo Perez Davila

    2015-01-01

    Introducción Las fracturas distales de tibia son un desafío para el tratamiento debido a la escasa cobertura y particular vascularización. Los objetivos del presente estudio son analizar los resultados clínicos y funcionales de los pacientes con fractura de tibia distal; tratados con técnica MIPO (minimally invasive plate osteosynthesis) con placas bloqueadas; comparar los resultados del grupo de fracturas tipo AO 43A con las tipo AO 43C1-C2; y comparar los resultados MIPO con el tratamie...

  15. América, la política internacional europea y las “relaciones de sucesos” españolas tras los tratados de Westfalia

    Directory of Open Access Journals (Sweden)

    Jesús Usunáriz

    2013-12-01

    Full Text Available Después de las paces de Westfalia (1648 la rivalidad hispano-francesa perduró el resto del siglo, a pesar de la firma de diferentes paces y tratados. Esto supuso un progresivo giro en la política exterior española que buscó la alianza ofensiva y defensiva con sus antiguas enemigas, las potencias marítimas de las Provincias Unidas e Inglaterra. En este giro, la América española jugó un papel de gran interés no tanto por su implicación en los incidentes militares o por el envío de remesas para el sostenimiento de las guerras europeas, sino porque sirvió de moneda de cambio para que este giro diplomático tuviera efecto y pudiera servir de freno y contrapeso a la estrategia hegemónica de Francia. Este papel jugado por las Indias quedó reflejado en crónicas, panfletos y “relaciones de sucesos”. After the peace of Westphalia (1648 Spanish-French rivalry continued for the rest of the century, despite of the signing of various treaties of peace. This was a gradual shift in Spanish foreign policy that sought an offensive and defensive agreement with its old enemies, the maritime powers of the Netherlands and England. In this situation Spanish America played a very interesting role not for its involvement in military incidents or for sending precious metals for the support of European wars, but because it served as a bargaining chip and as a check and balance to the hegemonic strategy of France. This role played by the Spanish Indies was reflected in chronicles, pamphlets and “relaciones de sucesos”.

  16. Solubilidade de metais pesados em solos tratados com lodo de esgoto enriquecido

    Directory of Open Access Journals (Sweden)

    C. Oliveira

    2003-02-01

    Full Text Available Os lodos de esgoto são materiais orgânicos ricos em nutrientes com potencial para o uso agrícola. A utilização desses materiais, no entanto, pode ser limitada pela presença de metais pesados na sua composição. Esta pesquisa teve por objetivos: (a avaliar a solubilidade de Cd, Pb e Zn em dois tipos de solos tratados com lodo de esgoto enriquecido com esses metais; (b verificar o efeito do tempo de contato nas mudanças da distribuição de Cd, Pb e Zn nas diferentes formas químicas de dois solos tratados com lodo de esgoto enriquecido com esses metais; (c verificar a influência das frações inorgânicas e orgânicas do lodo na dinâmica destes metais no solo. O enriquecimento do lodo de esgoto consistiu em adicionar Cd, Pb e Zn a um lodo de esgoto urbano produzido na Estação de Tratamento da Ilha do Governador (ETIG, Rio de Janeiro (RJ. Após 20 dias de incubação, sob umidade constante (50 % g g-1, o lodo enriquecido foi utilizado para a instalação de experimentos em amostras de duas classes de solos: Latossolo Vermelho-Amarelo (LV e Argissolo Vermelho-Amarelo (PV. Em laboratório, as amostras dos solos foram incubadas com quantidades equivalentes a 0; 20; 40 e 80 t ha-1 de lodo de esgoto enriquecido. Nos tempos de contato solo-lodo enriquecido de 4, 12, 16, 24 e 160 semanas, amostras de solos foram retiradas e submetidas à extração seqüencial de Cd, Pb e Zn. Observou-se, através da extração seqüencial, que compostos orgânicos solúveis formaram complexos, principalmente com cádmio e zinco, mantendo teores elevados destes elementos associados à fração solúvel em água durante todo o período experimental. A incorporação de compostos inorgânicos de Fe e Mn, através do lodo de esgoto, permitiu que o Cd, Pb e Zn se ligassem em sua maior parte, à fração extraível com hidroxilamina. Com o tempo de incubação, observou-se decréscimo dessa fração com aumento da fração residual, indicando decréscimo na

  17. Ribavirin exposure induces histopathological changes in the seminiferous tubules of testes in albino rats

    International Nuclear Information System (INIS)

    Batool, A.

    2013-01-01

    Study objectives: The objectives of the study are to describe and compare histopathological changes in the seminiferous tubules of testes of rat, with different doses of Ribavirin at different time intervals. Introduction: The chemical disturbances may affect a vast number of potential sites in male reproductive system as well as its complex hormonal regulation. Testicular toxicity may reduce the fertility of the male. The current study was conducted to evaluate the effects of Ribavirin on the histological structure of seminiferous tubules in the testes of albino rats. Materials and Methods: Seventy two sexually mature adult male albino rats weighing 180-200gms were divided into four groups: A, B, C and D; each group having 18 rats. Ribavirin was administered intraperitoneally in different doses to these groups that were 20mg, 100mg and 200mg/kg body weight, while group A was control. Each group was further divided into three subgroups according to three time points which were selected for sacrifice that were 20th, 40th and 60th day from the last exposure to drug. Six randomly selected rats from each group were sacrificed on every sacrifice time. Results and Conclusion: The seminiferous tubules with degenerative changes like appearance of vacuole and necrotic material were observed in comparison to control groups, on 20th day of sacrifice in all groups. In rats sacrificed on day 40th and 60th, the sign of recovery in the form of regeneration of seminiferous epithelium was observed that was more marked in low dose groups than high dose groups which showed late recovery. We conclude that ribavirin being used as antiviral drug induces reversible degenerative changes in the seminiferous tubules of testes of albino rats. (author)

  18. Investigaciones Terapéuticas en la Lepra: Ensayos con “Promín” o “Promanida'”

    Directory of Open Access Journals (Sweden)

    J. Ignacio Chala H.

    1948-07-01

    Full Text Available Con propósitos de observar, comprobar y valorar los resultados del "Promín"  o “Promanida” en la lepra, lo aplicarnos en un grupo de veintisiete enfermos seleccionados con criterio clínico y de investigación terapéutica. Iniciamos el estudio en julio de 1946. Ninguno de estos casos había sido tratado antes con otros medicamentos preconizados contra la enfermedad. Como lo he dicho en varias ocasiones, solamente teniendo esta precaución y seleccionando los pacientes para la investigación, podrá juzgarse científicamente de la eficacia terapéutica que puedan tener en los distintos tipos de lepra, las drogas aconsejadas para tratar esa enfermedad. Prescindimos de aquellos cases en los cuales, por lo avanzado del mal, los organismos no estaban en condiciones de reaccionar favorablemente con ninguna medicación.

  19. Measurement of genome changes of greenable albino mutation line c.v. W25

    International Nuclear Information System (INIS)

    Wu Dianxing; Xia Yingwu; Shu Qingyao; Zhang Yaozhou; Liu Guifu

    1997-01-01

    W25 was a greenable albino mutation line, which was derived from a temperature-sensitive genic male sterile rice 2177s, with 300 Gy gamma rays irradiation. During the whole growth duration, the leaves of W25 showed the following characters: white, greenism, albinism and greenism again. 70 primers were used for the detection of polymorphism, one of them gave polymorphic products. RAPD analysis of W25 and 2177s with random primer H05 indicated that there were two DNA bands differences

  20. Effect of protein malnutrition on the metabolism of bone collagen in albino rats

    Energy Technology Data Exchange (ETDEWEB)

    Rao, J S; Rao, V H [Central Leather Research Inst., Madras (India)

    1981-01-01

    The effect of protein malnutrition on the metabolism of collagen in bone was studied in young female albino rats after a single injection of /sup 3/H-proline. Both specific and total radioactivities of hydroxyproline in the total collagen of the bone were found to decrease in the protein-deficient animals, indicating decreased rate of collagen synthesis. In the urine the amount of hydroxyproline excreted and total radioactivity of /sup 3/H-hydroxyproline were greatly decreased. The results of the present investigation therefore clearly indicate decreased synthesis and catabolism of collagen in bones of protein deficient animals compared to controls.

  1. The effects of acute gasoline vapour inhalation on some haematological indices of albino Wistar rats

    OpenAIRE

    Chukwudi Onyeka John Okonkwo; Ailende Daniel Ehileboh; Eddy Nwobodo; Charles Chijioke Dike

    2016-01-01

    Objective: To find out if Gasoline vapour has some effects on haematological indices when inhaled by experimental rats. Methods: The standard method for laboratory operating procedure recommended by World Health Organization was used in all the analysis done. Forty two albino Wistar rats comprising twenty one males (160–220 g) and twenty one females (140–190 g) were sampled into six groups consisting of four test groups and two control groups. The test groups were exposed to gasoline vapou...

  2. INFLUENCE OF DIETARY FAT ON LEPTIN AND INSULIN IN MALE ALBINO RATS

    International Nuclear Information System (INIS)

    KASSAB, F.M.A.; ABDEL-KHALEK, L.G.; KAMAL, A.M.

    2008-01-01

    Sixty male albino rats were arranged into 5 equal groups which were used in this study to investigate the relation between leptin and insulin hormones under high fat intake and to assess the role of fresh vegetable intake on minimizing dyslipidemia.The results denoted that dietary fat caused significant increase in the levels of blood glucose and leptin hormone with significant decrease in insulin concentration and with prolonged high fat intake, insulin level was increased. However, the increased leptin and glucose indicated that prolonged fatty diet may cause insulin resistance. Addition of green vegetables to the diet normalized to a great extent the level of cholesterol, triglycerides, VLDL, glucose and insulin

  3. Glycogen metabolism in radiation induced hepatocellular carcinoma in Swiss albino mice

    International Nuclear Information System (INIS)

    Gupta, N.K.; Kumar, Ashok

    1988-01-01

    Glycogen content and the activities of phosphorylase, glycogen sythetase (GS), glucose 6-phosphatase (G6Pase), phosphohexose isomerase (PHI), glucose 6-phosphodehydrogenase were biochemically determined in the heparocellular carcinoma induced in swiss albino mice following radiocalcium internal irradiation. The content glycogen and the activities of phosphorylase, glycogen synthetase, G6Pase, PHI, GPT and GOT are considerably reduced in the hepatocellular carcinoma compared to that in control liver. However, the activity of G6PDH shows an increased activity. Results indicate that the decreas ed glycogen content in the hepatocellular carcinoma is due to the reduced glycogen synthetase activity and utilization of glucose by HMP pathway. (author). 2 tabs., 24 refs

  4. Analgesic activity of Nelsonia canescens (Lam.) Spreng.root in albino rats

    OpenAIRE

    Mohaddesi, Behzad; Dwivedi, Ravindra; Ashok, B. K.; Aghera, Hetal; Acharya, Rabinarayan; Shukla, V. J.

    2013-01-01

    Present study was undertaken to evaluate analgesic activity of root of Nelsonia canescens (Lam.) Spreng, a folklore medicinal plant used as the one of the source plant of Rasna. Study was carried out at two dose levels (270 mg/kg and 540 mg/kg) in albino rats. Analgesic activity was evaluated in formalin induced paw licking, and tail flick methods whereas indomethacin and pentazocine were used as standard analgesic drugs, respectively. At both the dose levels, test drug non-significantly decr...

  5. Response of peripheral blood to 131I treatment in Swiss albino mice

    International Nuclear Information System (INIS)

    Jagetia, G.C.; Gupta, S.M.; Kumar, S.; Devi, P.U.

    1982-01-01

    Adult Swiss albino mice were treated with 333 kBq/g body weight (approximately 10.22 Gy/day) intraperitoneally and sacrificed at different post-treatment intervals. It was observed that erythrocyte counts, hemoglobin and hematocrit values decreased gradually, while the depletion in leukocyte count was abrupt at early intervals after treatment. The early decline in the leukocytes followed by more gradual may be due to the direct cell killing by the isotope. The indirect effect on the hematopoietic tissues may be responsible for the continued low levels of the different blood constituents during the later intervals. (author)

  6. El reto de la contribución de la organización del Tratado de Cooperación Amazónica – OTCA– para el bienestar de las poblaciones locales y fronterizas

    Directory of Open Access Journals (Sweden)

    Fernando Franco Hernández

    2014-05-01

    Full Text Available El documento aborda la descripción de las dinámicas sociales, económicas y políticas de las poblaciones fronterizas asentadas en la Amazonia, que discurren en medio de situaciones de conflicto y con formas diferenciadas de presencia de los Estados nacionales y sus instituciones. El escrito expone las políticas de organismos multilaterales como la OTCA (Organización del Tratado de Cooperación Amazónica, que tienen como objetivo formular planes y agendas estratégicas en torno al desarrollo sostenible y al uso y conservación de los sistemas naturales amazónicos y sus recursos. El argumento central es que tales políticas, planes y programas tienen un impacto mínimo en la resolución de los problemas y conflictos que enfrentan los pueblos amazónicos, dada la ausencia de instrumentos que articulen las formulaciones de carácter general con propuestas y proyectos que conduzcan al desarrollo sostenible y a un mejor vivir de las poblaciones amazónicas a escala regional.

  7. Effect of Piper betel leaf stalk extract on protein metabolism in reproductive tissues of male albino rats

    OpenAIRE

    V Vengaiah; A Govardhan Naik; C Changamma

    2015-01-01

    Objective: To know the impact of Piper betel leaf stalk (P. betel) extract on Protein and energy metabolism and its role in male albino rats. Methods: Healthy adult (3-4 months old) male Wistar strain albino rats were administered with betel leaf stalk extract, at the dose of 50 mg/kg/day through oral gavages for 15 days. Twenty four hours after the last dose, the animals were autopsied. In order to assess antifertility effect in testis, epididymis, seminal vesicle and prostate gland, esti...

  8. Produção de moranga irrigada com esgoto doméstico tratado

    Directory of Open Access Journals (Sweden)

    Pedro C. P. de Oliveira

    2013-08-01

    Full Text Available Objetivou-se, neste trabalho, avaliar a produção de moranga (Cucurbita maxima Duch. Cv Coroa IAC irrigada com esgoto doméstico tratado. O delineamento experimental foi em blocos casualizados com cinco tratamentos e quatro repetições. Os tratamentos se constituíram de : T1- irrigação com lâmina de 150% da demanda hídrica da cultura; T2- irrigação com lâmina de 150% + adição de CaSO4 no solo; T3- irrigação com lâmina de 100% da demanda hídrica da cultura; T4- irrigação com lâmina de 100% + adição de CaSO4 no solo e T5- tratamento testemunha (sem irrigação. Foram avaliados a produtividade da cultura, o peso e o número de frutos, suas características físico-químicas (pH, acidez total, sólidos solúveis, açúcares totais, açúcares redutores e açúcares não redutores e potencial de contaminação por agentes patogênicos na água. Foi identificada diferença significativa entre o tratamento testemunha e os demais tratamentos em relação à produção, produtividade e número de frutos. As características físico-químicas apresentaram valores similares em todos os tratamentos. Foi registrada a presença de coliformes termo tolerantes somente na superfície externa dos frutos porém em níveis abaixo dos padrões mínimos estabelecidos pelas normas sanitárias.

  9. Lixiviação de metais pesados em solos tratados com lodo de esgoto

    Directory of Open Access Journals (Sweden)

    E. I. Bertoncini

    1999-09-01

    Full Text Available Foi realizado um experimento em tubos de percolação, utilizando-se três solos, classificados como Areia Quartzosa (AQ, Latossolo Vermelho-Amarelo (LV e Latossolo Vermelho-Escuro (LE, aos quais foram incorporadas sucessivas quantidades de lodo de esgoto, totalizando uma dose correspondente a 156,0 t ha-1 (base seca, num período de incubação de 310 dias. Após este período, os solos foram tratados com água ou com soluções de sais (KCl 0,9 mol L-1; KNO3 0,9 mol L-1; K2SO4 0,3 mol L-1 e Ca(NO32 0,3 mol L-1, adicionadas em quantidade correspondente a quatro vezes a capacidade de retenção de água dos solos. No líquido percolado pela passagem das soluções salinas, foram determinadas as quantidades de Cd, Cr, Cu, Ni e Zn presentes e, no percolado obtido com a passagem de água, além dos metais anteriormente citados, foram determinadas também as quantidades de Ca2+ e Mg2+. Os resultados permitiram observar que a adição de KCl provocou o arraste de 5% do Cd adicionado via lodo aos solos LV e LE; para os outros sais utilizados e para a água, esse arraste nunca foi superior a 2% do metal pesado adicionado via lodo. A retenção de Cd, Cu, Cr e Ni aumentou com a elevação dos teores de óxidos de Fe e Al presentes nos solos. Os elevados valores de pH e o aumento no teor de matéria orgânica proporcionado pela adição de lodo refletiram também na menor mobilidade dos metais. Os sais KCl e K2SO4 aumentaram a mobilidade de alguns dos metais estudados.

  10. The Protective Role of Ginger (Zingiber Officinales ) in Male Albino Rats Exposed to Gamma Irradiation

    International Nuclear Information System (INIS)

    Osman, H.F.

    2008-01-01

    The present work was performed to evaluate the effectiveness of preirradiation treatment with ginger (Zingiber Officinales) for 21 consecutive days before exposure in controlling post-irradiation hazards in male rats. Male albino rats weighing about 120±10 g were divided into four groups: ( I ) control, ( II ) treated with ginger 200 mg/kg , ( III ) irradiated with 6 Gy and ( IV ) treated with ginger 200 mg/kg before irradiated with 6 Gy gamma - radiation . The blood samples were collected from heart of animals 21 days after treatment with ginger and seven days post irradiation. Blood samples were subjected to biochemical analysts such as liver functions , lipid profile , kidney function and sex hormone. Whole body gamma irradiation of rats at 6 Gy (single dose) caused significant increase in (aspartate and alanine aminotransferases (AST and ALT), cholesterol, triglycerides , glucose, urea and creatinine) while alkaline phosphatase showed no effect. Irradiation caused decrease in the contents of total protein , albumin and testosterone. Ginger treatment exerted noticeable amelioration in the studied biochemical parameters of the irradiated albino rats. The mechanism of action of ginger may be due to its antiinflammatory properties against whole body gamma irradiation

  11. Effect of GABAB Receptor Antagonist (CGP35348 on Learning and Memory in Albino Mice

    Directory of Open Access Journals (Sweden)

    Quratulane Gillani

    2014-01-01

    Full Text Available The present study was designed to demonstrate the potential effect of CGP 35348 (GABAB receptor antagonist on the learning, memory formation, and neuromuscular coordination in albino mouse. Mice were intrapertoneally injected with 1 mg CGP 35348/mL of distilled water/Kg body weight, while the control animals were injected with equal volume of saline solution. A battery of neurological tests was applied following the intrapertoneal injections. Results of rota rod indicated that CGP 35348 had no effect on neuromuscular coordination in both male (P=0.528 and female (P=0.125 albino mice. CGP 35348 treated females demonstrated poor exploratory behavior during open filed for several parameters (time mobile (P=0.04, time immobile (P=0.04, rotations (P=0.04, and anticlockwise rotations (P=0.038. The results for Morris water maze (MWM retention phase indicated that CGP 35348 treated male mice took shorter latency to reach the hidden platform (P=0.04 than control indicating improved memory. This observation was complemented by the swim strategies used by mice during training days in MWM as CGP 35348 treated males used more direct and focal approach to reach the platform as the training proceeded.

  12. Protection against radiation induced testicular damage in Swiss albino mice by mentha piperita (Linn)

    Energy Technology Data Exchange (ETDEWEB)

    Samarth, Ravindra M; Samarth, Meenakshi [Rajasthan Univ., Jaipur (India). Dept. of Zoology, Radiation and Cancer Biology Lab.

    2008-07-01

    Mentha piperita linn or peppermint (Family - Labiatae) is aromatic and has stimulant and carminative properties. The protective effects of mentha piperita (Linn) extract against radiation induced damage in testis of Swiss albino mice have been studied. Animals (Male Swiss albino mice) were given leaf extract of M. piperita orally (1 g kg{sup -1} day{sup -1}) for three consecutive days prior to radiation exposure (8 Gy gamma radiation). Mice were autopsied at 1, 3, 7, 14 and 30 days of post-irradiation to evaluate the radiomodulatory effect in terms of histological alterations, lipid peroxidation, acid and alkaline phosphatases levels in testis. There was significantly less degree of damage to testis tissue architecture and various cell populations including spermatogonia, spermatids and Leydig cells. Significant decreases in the LPO and acid phosphatase level and increase in level of alkaline phosphatase were observed in testis. The methanolic extract of M. piperita showed high amount of phenolic content, flavonoids content and flavonol. Leaf extract of M. piperita has significant radioprotective effect and the amount of phenolic compounds, flavonoids and flavonol content of extract of M. piperita may be held responsible for its radioprotective effect. (author)

  13. Lack of beneficial effect of activated charcoal in lead induced testicular toxicity in male albino rats

    Directory of Open Access Journals (Sweden)

    Samuel James Offor

    2017-09-01

    Full Text Available Objective: Lead is a multi-organ toxicant implicated in various diseases including testicular toxicity. In search of cheap and readily available antidote this study has investigated a beneficial role of activated charcoal in lead induced testicular toxicity in male albino rats. Materials and Method: Eighteen male albino rats were divided into three groups of six rats per group. Group 1 (control rats received deionised water (10 ml/kg, group 2 was given lead acetate solution 60 mg/kg and group 3 rats were given lead acetate (60 mg/kg followed by Activated charcoal, AC (1000 mg/kg by oral gavage daily for 28 days. Absolute and relative weights of testis, epididymal sperm reserve, testicular sperm count, percent sperm motility and percent sperm viability were monitored. Results: AC failed to show any significant beneficial effect in ameliorating lead induced testicular toxicity. Conclusions: There seem to be a poor adsorption on lead onto AC in vivo.

  14. Impact of Sexual Deprivation on Sexual Behavior and Some Reproductive-Endocrinal Functions in Albino Rats

    Directory of Open Access Journals (Sweden)

    Sadek S. Abd El Moghny

    2016-12-01

    Full Text Available Objective: To study the effect of stress on the sexual behavior and its pathophysiological effects on some reproductive and endocrine functions in albino rats. Methods: One hundred and twenty albino rats were included and divided into a control groupand three exper-imental sub-groups, which were subjected to sexual stress. Female rats were investigated for the cytological changes in the phases of the estrous cycle. All rats were observed for behavioral changes throughout the experiment. Histopathological examination of the thyroid, testes and ovaries and the assessment of thyroid and gonadal hormones in the sera of control and experimental rats were performed. Results: Cytological examination revealed stopped estrous cycle in the diestrous phase in all female rats. Thyroid hormones revealed a decrease in the levels of triiodothyronine and thyroxin; however, non-significant changes were detected in the thyroid-stimulating hormone level in experimental rats compared to the controls. Gonadal hormones revealed a great discrepancy in their levels among both sexes. Conclusions: The results of the present study show that sexual excitation is one of the stressful factors affecting sexual behavior, hypothalamic-pituitary-thyroid and hypothalamic-pituitary-gonadal axes as well as sex organs with secretory functions. Therefore, it is considered as a socio-pathological factor that needs more specific studies to further clarify its effects.

  15. The protective role of damsissa (Ambroosia Maritima) against gamma irradiation in albino rats

    International Nuclear Information System (INIS)

    Osman, O.A.; Mohamed, Y.S.

    2003-01-01

    The present work was directed to evaluate the effectiveness of treatment with damsissa (Ambrosia maritima) for thirty consecutive days pre- irradiation exposure in controlling the post-irradiation hazards in irradiated rats. Male albino rats (Spraue Dowley strain) weighing about 120+- 10 g were used and blood samples were collected from tails of animals thirty days after treatment with damsissa and seven days post irradiation. Blood samples were subjected to biochemical analysis such as liver functions, kidney function and lipid profile. Whole body gamma irradiation of rats at 6 Gy (single dose) caused significant decrease in the contents of total proteins accompanied by significant increase of urea level as recorded on the 7th days post irradiation. Data obtained in this study revealed that whole body gamma irradiation induced significant elevation in all tested blood lipid functions. There was significant increase of aspartate amino transferase (AST) and alanine amino transferase (ALT) whole alkaline phosphatase (ALP) showed statistical significant decrease as compared with the control group. Damisissa (Ambrosia maritima) treatment exerted noticeable amelioration in the the studied biochemical parameters of the irradiated albino rats. The mechanism of action of damsissa may be due to its anti-inflammatory properties against whole body gamma irradiation

  16. Effect of Some Antioxidants on the Physical Fitness of Albino Rats

    International Nuclear Information System (INIS)

    Michael, M.I.

    2011-01-01

    In recent years, more attention has been paid for searching of natural antioxidants and their evaluation in either medicinal practice or as food raw materials. The aim of the present research is to assess the effect of several well-known products used as antioxidants, on body weight, haemopoesis, endocrine system and lipid profile in normal albino rats. Thirty male adult albino rats were equally arranged into 5 groups, the first group was served as control and the others received special treatments where taurine (2% in drinking water), tryptophan (100 mg/kg b.w. orally), hawthorn extract (50 mg/100 g b.w. orally) and coenzyme Q10 (50 mg/kg b.w. orally) were given for two months. Body weight was regularly recorded twice a week and at the end of the experiment, the rats were decapitated. Red blood cell count (RBCs), hemoglobin (Hb) content, reticulocytic count, white blood cell count (WBCs) and glutathione (GSH) concentration were estimated in blood, while, triiodothyronine (T 3 ), thyroxin (T 4 ), Testosterone, and corticosterone hormones besides lipid profile were estimated in the serum. The results denoted that although there is a slight improvement in the parameters tested, it does not deserve the coast of the regular use of these antioxidants and further investigations still needed

  17. Protection against radiation induced testicular damage in Swiss albino mice by mentha piperita (Linn)

    International Nuclear Information System (INIS)

    Samarth, Ravindra M.; Samarth, Meenakshi

    2008-01-01

    Mentha piperita linn or peppermint (Family - Labiatae) is aromatic and has stimulant and carminative properties. The protective effects of mentha piperita (Linn) extract against radiation induced damage in testis of Swiss albino mice have been studied. Animals (Male Swiss albino mice) were given leaf extract of M. piperita orally (1 g kg -1 day -1 ) for three consecutive days prior to radiation exposure (8 Gy gamma radiation). Mice were autopsied at 1, 3, 7, 14 and 30 days of post-irradiation to evaluate the radiomodulatory effect in terms of histological alterations, lipid peroxidation, acid and alkaline phosphatases levels in testis. There was significantly less degree of damage to testis tissue architecture and various cell populations including spermatogonia, spermatids and Leydig cells. Significant decreases in the LPO and acid phosphatase level and increase in level of alkaline phosphatase were observed in testis. The methanolic extract of M. piperita showed high amount of phenolic content, flavonoids content and flavonol. Leaf extract of M. piperita has significant radioprotective effect and the amount of phenolic compounds, flavonoids and flavonol content of extract of M. piperita may be held responsible for its radioprotective effect. (author)

  18. Effects of L-cysteine on lead acetate induced neurotoxicity in albino mice.

    Science.gov (United States)

    Mahmoud, Y I; Sayed, S S

    2016-07-01

    Lead is a toxic heavy metal that adversely affects nervous tissues; it often occurs as an environmental pollutant. We investigated histological changes in the cerebral cortex, hippocampus and cerebellum of adult albino mice following exposure to lead acetate. We also studied the possible ameliorative effect of the chelating agent, L-cysteine, on lead-induced neurotoxicity. We divided albino mice into six groups: 1) vehicle-only control, 2) L-cysteine control, 3 and 4) treated for 7 days with 20 and 40 mg/kg lead acetate, respectively, and 5 and 6) treated for 7 days with 20 and 40 mg/kg lead acetate, respectively, followed by 50 mg/kg L-cysteine for 7 days. Lead acetate administration caused disorganization of cell layers, neuronal loss and degeneration, and neuropil vacuolization. Brain sections from lead-intoxicated mice treated with L-cysteine showed fewer pathological changes; the neuropil showed less vacuolization and the neurons appeared less damaged. L-cysteine at the dose we used only marginally alleviated lead-induced toxicity.

  19. Wound healing activity of methanolic stem extract of Musa paradisiaca Linn. (Banana) in Wistar albino rats.

    Science.gov (United States)

    Amutha, Kuppusamy; Selvakumari, Ulagesan

    2016-10-01

    This study is designed to explore the phytochemical, antibacterial and wound healing activity of methanolic stem extract of Musa paradisiaca Linn. (Banana). The phytochemical analysis was performed for the methanolic stem extract of Musa paradisiaca Linn. Results indicates that the Musa paradisiaca Linn. was rich in glucosides, tannins and alkaloids, saponins, flavonoids and phenols were present in moderate quantities. The extract shows antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus with the zone of inhibition of Pseudomonas aeruginosa was 21 mm and Staphylococcus aureus was 19 mm at concentration of 500 µg/disc. The minimum inhibitory concentration (MIC) was also evaluated for the extract. Wistar albino rats were selected for wound healing activity. The burn wound was created by using red hot steel rod from above the hind limb region. The methanolic extract was applied on the wound and the progressive changes were monitored every day. The wound contraction rate was absorbed based on the histopathological examination. It was concluded that the methanolic extract of Musa paradisiaca Linn. showed greater healing activity compared to control in Wistar albino rats. © 2014 The Authors. International Wound Journal © 2014 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

  20. Antioxidant activity of eggplant (Solanum melongena) in male albino rats exposed to gamma irradiation

    International Nuclear Information System (INIS)

    Abdel-Magied, N.; Ahmed, A.G.; Abo zid, N.M.

    2012-01-01

    The aim of the study was to evaluate the potential benefits of dietary supplementation of eggplant (Solanum melongena) as antioxidant against γ- rays-induced biochemical changes in male albino rats by estimating some of the components of antioxidant defense in the; liver glutathione content (GSH), superoxide dismutase activity (SOD) and malondialdehyde (MDA), serum aspartate amino transferase,(AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), gamma glutamyl transaminase (GGT), cholesterol, triglycerides, low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol(HDL-C). Male albino rats (120-150 g) were divided into four groups as Control group, group 2 received diet supplemented with 10% of eggplant (Solanum melongnea) fruit for 21 successive days , group 3: irradiated with a single dose (6.5 Gy), group 4 received eggplant for 21 successive days then exposed to 6.5 Gy. All animals were sacrificed after 1, 3 and 8 days post irradiation. Rats exposed to γ-rays exhibited a profound elevation of AST, ALT, ALP and GGT activities, and lipid abnormalities .Noticeable drop in liver GSH content and SOD activity associated with increase of MDA was recorded. Treatment with dietary eggplant for 21 days before irradiation significantly abolished radiation induced elevations in MDA and significantly elevates hepatic GSH content and SOD activity. The levels of cholesterol, TG, HDL-C, LDL-C as well as the activities of AST, ALT, and GGT in serum were significantly ameliorated and noticeable improvement in the lipid profile levels

  1. Effect of melatonin on serum glucose and body weights in streptozotocin induced diabetes in albino rats

    International Nuclear Information System (INIS)

    Hidayat, M.

    2015-01-01

    It has been demonstrated in experimental animal models that oxidative stress causes persistent and chronic hyperglycaemia, causing reduction in antioxidant defence system, ultimately leading to accumulation of free radicals.This study was performed to observe the effect of melatonin on serum glucose and body weights in streptozotocin induced diabetes in albino rats. Methods: Forty healthy adult male albino rats were included in the study and divided equally into 4 groups for 6 weeks. Group-A was taken as control. Group-B received streptozotocin I/P in a dose of 37 mg/kg body weight. Group-C received 10 mg/100 ml melatonin in drinking water and Group-D received only melatonin. Results: Streptozotocin significantly increased serum glucose and decreased weight in group B animals, whereas in group C, melatonin significantly restored serum glucose but could not restore the body weights reduced by streptozotocin. There was a significant reduction in body weight in melatonin treated group D animals. Conclusion: Melatonin decreases oxidative stress and hyperglycemia, but cannot restore the body weight reduced by streptozotocin. In fact, it further reduces body weight both in diabetic and normal state. (author)

  2. Histological and Physiological Alterations Induced by Thermal Neutron Fluxes in Male Swiss Albino Mice

    International Nuclear Information System (INIS)

    Alzergy, A.A.; Emara, N.M.; Abd El-Latif, A.A.; El-Saady, S.M.M.; Emara, N.M.; Abd El-Latif, A.A.

    2010-01-01

    This work was performed to investigate the biological effects of different thermal neutron fluxes (0.27x10 8 , 0.52X10 8 , 1.089X10 8 , 2.16X10 8 and 4.32X10 8 ) on liver and kidney of male mice using neutron irradiation cell with Ra-Be(α,n) 3 mCi neutron source Leybold (55930). Exposed to various fluxes of thermal neutron induced a dramatic alterations in hepatic and renal functions as indicated by biochemical estimation of several parameters (bilirubin, SGT, and alkaline phosphate .Urea , total protein, and albumin) and confirmed by histological examinations Thermal neutron exposure induces marked increase in the serum activities of total bilirubin, alanine amino transaminase (ALT or GPT), and alkaline phosphate, whereas, urea, total protein and albumin showed marked decline as compared to control group. The physiological changes induced in thermal neutron fluxes dependent manner. Histopathological results revealed mild to severe type of necrosis, and degenerative changes in liver and kidney of male mice exposed to thermal neutron fluxes. Also it was found that the histopathological alterations induced in thermal neutron fluxes dependent manner. It was found that exposed to thermal neutron fluxes irradiation plays prominent role in the development of the physiological alterations in male Swiss albino mice. The Former up normalities as a result of the sequence events followed interaction of radiation with the former biological mater (liver and kidney) of male Swiss albino mice, which are, physical, physicochemical, chemical, and biological stages.

  3. Dietary Antioxidants Effectiveness on Carbon Tetrachloride-Induced Hepatotoxicity in Adult Female Albino Rats

    International Nuclear Information System (INIS)

    EI-Sherbiny, E.M.; EI-Mahdy, A.A.

    2008-01-01

    Hepatic toxicity through carbon tetrachloride (CCI 4 ) induced lipid peroxidation was extensively used in experimental models to understand the cellular mechanisms behind oxidative damage and to evaluate the therapeutic potential of drugs and dietary antioxidants. The ameliorative effect of Aloe vera juice and carrot supplementation on hepato carcinogenesis induced by carbon tetrachloride in adult female albino rats was investigated. The carcinogenic process was determined by measuring gamma-glutamyl transpeptidase (GGT), ornithine carbamyl transferase (OCT), thiobarbituric acid reactive substances (TBARs), representing levels of lipid peroxides, and carcinoembryonic antigen (CEA) in the sera of female albino rats. Carbon tetrachloride significantly elevated the serum GGT, OCT activities and the level of TBARs. Administration of Aloe vera leaf juice filtrate after CCl 4 treatment resulted in a non-significant modification in GGT, OCT activities and significantly improved the level of TBARs in comparison with control. Supplementation of carrot to CCI 4 treated animals led to a great amelioration in OCT activity and TBARs level, whereas GGT activity was ameliorated but statistically changed compared to control. There was a non-significant alteration in the level of CEA in all treated groups compared to normal control one

  4. Effect of chronic exposure to aspartame on oxidative stress in the brain of albino rats.

    Science.gov (United States)

    Iyyaswamy, Ashok; Rathinasamy, Sheeladevi

    2012-09-01

    This study was aimed at investigating the chronic effect of the artificial sweetener aspartame on oxidative stress in brain regions of Wistar strain albino rats. Many controversial reports are available on the use of aspartame as it releases methanol as one of its metabolite during metabolism. The present study proposed to investigate whether chronic aspartame (75 mg/kg) administration could release methanol and induce oxidative stress in the rat brain. To mimic the human methanol metabolism, methotrexate (MTX)-treated rats were included to study the aspartame effects. Wistar strain male albino rats were administered with aspartame orally and studied along with controls and MTX-treated controls. The blood methanol level was estimated, the animal was sacrificed and the free radical changes were observed in brain discrete regions by assessing the scavenging enzymes, reduced glutathione, lipid peroxidation (LPO) and protein thiol levels. It was observed that there was a significant increase in LPO levels, superoxide dismutase (SOD) activity, GPx levels and CAT activity with a significant decrease in GSH and protein thiol. Moreover, the increases in some of these enzymes were region specific. Chronic exposure of aspartame resulted in detectable methanol in blood. Methanol per se and its metabolites may be responsible for the generation of oxidative stress in brain regions.

  5. El proceso de negociación del Tratado de Libre Comercio entre Colombia y Estados Unidos

    OpenAIRE

    Cadena Cancino, Adriana Rocío

    2008-01-01

    La presente investigación analiza la negociación del Tratado de Libre Comercio entre Colombia y Estados Unidos como policy process, lo que condujo a reconstruir la etapa de formación de agenda de la política en cuestión, a identificar las acciones que llevaron a cabo los actores involucrados (particularmente el poder ejecutivo del Estado colombiano, los legisladores, los negociadores, los sindicatos, los grupos de la sociedad civil y los empresarios), así como las estrategias empleadas en la ...

  6. EVALUACIÓN DE LAS TÉCNICAS DE CEPILLADO DE BASS Y VERTICAL EN UN GRUPO DE PACIENTES EN TRATAMIENTO DE ORTODONCIA CON TÉCNICA MBT

    OpenAIRE

    Yelitza Ivone Baracaldo Ortíz; Fredy Alexander Cabuya Cabuya; Rubén Darío Hurtado Rozo; Edwin Emil Ricaurte Vila; Diana Constanza Gamboa Martínez; Liliana Carolina Báez Quintero

    2012-01-01

    Objetivo: Evaluar la efectividad de las técnicas de Cepillado de Bass y Vertical en pacientes con aparatología ortodóntica fija tratados con la técnica MBT. Materiales y métodos: se realizó un estudio experimental “In vivo” aleatorizado doble ciego; la muestra fue de 100 personas distribuidas en dos grupos, a cada uno se le asignó una Técnica de Cepillado y se dieron instrucciones de higiene oral por medio de charlas personalizadas y por escrito. Se usó el índice de Sillnes y Löe para medir e...

  7. Análisis e Identificación de las Potenciales Oportunidades Comerciales con Países miembros del TPP en el Sector de Alimentos Frescos

    OpenAIRE

    Malca Guaylupo, Oscar; Florián Mendo, Samir; Barrantes Rivas, Sofía; Cerdán Torres, Sara; Zhu Gálvez, Eloha

    2016-01-01

    La estructura de las exportaciones peruanas se ha basado a lo largo de los años en productos tradicionales cuya naturaleza se puede explicar a partir del patrón de ventajas comparativas que posee el Perú. Con el objetivo de intensificar los flujos comerciales hacia un mayor número de mercados, el Perú ha firmado muchos tratados comerciales y, siguiendo con la estrategia, ha concluido negociaciones del Acuerdo Trans-Pacific Partnership (TPP). Sin embargo, las participaciones de mercado del Per...

  8. Análisis e identificación de las potenciales oportunidades comerciales con países miembros del TPP en el sector de alimentos frescos

    OpenAIRE

    Malca, Oscar; Florián Mendo, Samir; Barrantes Rivas, Sofía; Cerdán Torres, Sara; Zhu Gálvez, Eloha

    2016-01-01

    La estructura de las exportaciones peruanas se ha basado a lo largo de los años en productos tradicionales cuya naturaleza se puede explicar a partir del patrón de ventajas comparativas que posee el Perú. Con el objetivo de intensificar los flujos comerciales hacia un mayor número de mercados, el Perú ha firmado muchos tratados comerciales y, siguiendo con la estrategia, ha concluido negociaciones del Acuerdo Trans-Pacific Partnership (TPP). Sin embargo, las participaciones de mercado del Per...

  9. Interacciones farmacológicas de las hojas de Maytenus macrocarpa o “chuchuhuasi” con fármacos inhibitorios y estimuladores de la motilidad intestinal

    OpenAIRE

    Meléndez-Espíritu, S.; Huaccho Rojas, Juan Jesús; Santos-Cajahuanca, F.; Abanto-Cabeza, C.; Jáuregui-Farfán, J.; Mendoza-Toribio, J.; Morales-Zenteno, E.; Salgado-Silva, L.; Sueyoshi-Hernández, H.; Robles-Ojeda, M.; Loja Herrera, Berta; Alvarado Yarasca, Ángel Tito; Salazar Granara, Alberto Alcibíades

    2013-01-01

    OBJETIVO: Determinar las posibles interacciones farmacológicas de las hojas de Maytenus macrocarpa, con fármacos estimulantes e inhibitorios de la motilidad intestinal. MÉTODOS: Se utilizaron 110 ratones albinos machos, con pesos medios de 25 g, se empleó el método de Arbos y col, se administró carbón activado al 5 % vía oral, dosis de 0.1ml/10g, como marcador intestinal. Los grupos experimentales fueron: control (agua destilada 0,3ml), hojas de chuchuhuasi 1 (500mg/kg), hojas de chuchuhua...

  10. Mercurius solubilis en el tratamiento de pacientes con estomatitis aftosa recurrente

    Directory of Open Access Journals (Sweden)

    María Isabel Aguilar Vallejo

    2015-01-01

    Full Text Available Se realizó ensayo clinicoterapéutico controlado, de fase II B, de 112 pacientes con estomatitis aftosa recurrente, atendidos en la Clínica Estomatológica "José Luis Tassende" de Santiago de Cuba, desde enero hasta diciembre de 2013, para evaluar la eficacia del Mercurius solubilis en el tratamiento de estos. La muestra fue distribuida de forma aleatoria, mediante orden de llegada, en 2 grupos (uno de estudio y uno control, con 56 integrantes cada uno. Los primeros fueron tratados con Mercurius solubilis y los segundos con los remedios homeopáticos habituales. Para la validación estadística de la información obtenida se emplearon el porcentaje, el test de Ji al cuadrado, con 95 % de confiabilidad, y la probabilidad exacta de Fisher. Entre los grupos estudiados no existieron diferencias significativas en relación con la remisión de la intensidad del dolor, la recuperación de la integridad epitelial y la curación al tercer, quinto y séptimo días de tratamiento. Se demostró que esta terapia alternativa fue tan eficaz como el bórax

  11. Eficacia del tratamiento acupuntural en pacientes con sacrolumbalgia de causa no neurológica

    Directory of Open Access Journals (Sweden)

    Arthur Smith Austin

    2013-12-01

    Full Text Available Se realizó un ensayo clinicoterapéutico de fase II de 120 pacientes con sacrolumbalgia no neurológica, atendidos en el cuerpo de guardia y en la consulta ambulatoria del Instituto Superior de Medicina Militar "Dr. Luis Díaz Soto" y del Hospital Militar Central "Dr. Carlos J. Finlay", desde enero de 2009 hasta junio de 2010, con vistas a evaluar la eficacia del tratamiento acupuntural. Se conformaron 2 grupos de 60 integrantes cada uno, los cuales fueron comparados con un grupo control con la misma cantidad de pacientes, pero con tratamiento farmacológico. Se obtuvo que los tratados con acupuntura mejoraron en menor tiempo, en particular los del grupo 2, de donde se infiere que esta técnica resultó eficaz para aliviar el dolor lumbar en quienes se aplicó, a la vez que permitió a los enfermos reducir el período de tratamiento, ahorrar medicamentos y lograr una rápida reincorporación a la vida laboral y social.

  12. Diseñe su interfaz gráfica con Matlab

    Directory of Open Access Journals (Sweden)

    Miguel Ramón Ortegón Gutiérrez

    1998-05-01

    Full Text Available Las aplicaciones de carácter científico o tecnológico cuentan, para su desarrollo, con el apoyo de una poderosa herramienta de cálculo numérico, que permite abordar problemas que demanden variada y compleja manipulación matemática de manera eficiente y con ayudas gráficas. Su diseño funcional le permite usar con facilidad toda la gama de comandos en forma interactiva, o en modo programas que han sido implementados como parte del lenguaje, o los nuevos comandos implementados por el usuario. Problemas tradicionales, relativos al manejo de matrices o álgebra lineal, cálculo diferencial e integral, ecuaciones diferenciales, raíces de funciones, solución de sistemas de ecuaciones, etc., hasta algunos más especializados como el procesamiento digital de señales, redes neuronales, filtros, pueden ser tratados con este lenguaje. Con el presente artículo se desea difundir el uso de interfaces gráficas que provee Matlab, para hacer más modernas, presentables y manejables aplicaciones de ingeniería que con otras herramientas podrían resultar mas complicadas y engorrosas.

  13. Adverse effects to iodinated contrast media in interleukin-2 treated patients; Reacciones adversas a los medio de contraste yodados en pacientes tratados con interleuquina 2

    Energy Technology Data Exchange (ETDEWEB)

    Vias, I.; Nicolas, A. I.; Lopez Picazo, J. M.; Elduayen, B.; Delgado, C.; Ano, M.; Fernande-villa, T.; Garcia del Barrio, L.; Velazquez, P.; Bilbao, J. I. [Universidad de Navarra. Pamplona (Spain)

    2000-07-01

    Interleukin-2 (IL-2) is a potent modulator of immune response that provokes tumor regression in cancer patients. IL-2 may induce sensitization to radiological iodinated contrast media (ICM) and this phenomenon has been rarely reported in literature. We report the increased incidence of adverse reactions to ICM patients treated with systemic IL-2, discuss the possible mechanisms of action, and propose patient management strategies. Retrospective study was conducted in 168 patients treated with subcutaneous IL-2 and 544 patients who did not.CT scans were performed with intravenous administration of 80-160 ml of nonionic ICM with a power injector. The incidence of adverse reactions to ICM among our patients was 7.14%. It differs significantly (p<0.001) from that in the control group (1.28%). Thus, patients treated with IL-2 have a relative risk of 5,6 times (CI 95%; 2.2-13.9). The adverse reactions in IL-2 patients were mild and resolved promptly without treatment in 11 patients. In one patient hypotension required intravenous forced hydration. Patients on IL-2 treatment may be at risk of experiencing contrast induced adverse reactions. Potent of the immune system by IL-2 may increase the potential risk for hypersensitivity or other adverse reactions to ICM. Knowledge of this fact may be valuable in clinical decision making and patient follow-up strategies. (Author) 18 refs.

  14. Pythiosis cutánea en equinos tratados con acetonida de triamcinolona. Parte 1. Caracterización clínica

    Directory of Open Access Journals (Sweden)

    José Cardona-Álvarez

    2016-09-01

    Full Text Available Objective. The objective of the present study was to characterizer clinically of the healing process of cutaneous pythiosis in horses treated with triamcinolone acetonide. Materials and methods. We conducted a descriptive study, not probabilistic, of convenience. 24 horses were used with cutaneous pythiosis confirmed, a group of 12 animals was administered 50 mg of intramuscular injection of triamcinolone acetonide (TG and the other group was not applied any treatment (CG. They are undergoing clinical and microscopic characterization of the lesion every 4 days until the complete recovery of granuloma in the GT. Being verified decreased fibrin bloody exudate, pruritus, presence of fistulae and output kunkers, likewise radiographic projections were performed to assess the degree of compromise bone and tissue fibrosis. Results. Macroscopically animals GT present progressive decrease in the clinical features of the disease at 16±1.4 days post treatment application. The wound contraction was 100% at 60±3.4 days after application of the treatment in all granulomas of GT, being highly significant (p<0.0001. Radiological monitoring of chronic skin lesions, met invasion to underlying tissues compromising bone structures, characterized by tissue fibrosis, moderate exostosis, bake as osteolysis and osteomyelitis. Neither of the animals in the CG showed improvement in clinical characteristics, and macroscopic of pythiosis and maintained equal to the first day throughout the study. Conclusions. The use of triamcinolone acetonide is a good therapeutic alternative for the treatment of granulomatous Pythiosis wounds in horses with 100% clinical recovery.

  15. Estudio de hiperglicemia en pacientes no críticos tratados con nutrición parenteral: incidencia y factores de riesgo

    OpenAIRE

    Llop, J. M.; Leiva, E.; Mateu-de Antonio, J.; Berlana, D.; Badia, M.; Casasín, T.; Miana, M.; Pons, M.; Maroto, M.; Chicharro, L.; López-Suñé, E.; Díaz-Munio, E.; Sevilla, D.; Martínez, I.; Vitales, M.

    2012-01-01

    Background: The objectives of our study on non-critically ill patients receiving parenteral nutrition (PN) are to assess the incidence of hyperglycemia, the risk factors associated to its development and its influence in patient's evolution. Methods: A multicentric prospective observational study was performed in 9 hospitals. Four multivariate studies were developed to study the temporal risk in the occurrence of hyperglycemia (endpoint), intensive care unit (ICU) admission, length of stay (L...

  16. Estudio del virus JC, agente causal de la leucoencafalopatía multifocal progresiva, en pacientes de esclerosis múltiple recurrente-remitente tratados con Natalizumab

    OpenAIRE

    Domínguez Mozo, María Inmaculada

    2013-01-01

    La esclerosis múltiple (EM) es una enfermedad desmielinizante inflamatoria crónica que afecta al sistema nervioso central (SNC) y cuyo origen es presumiblemente autoinmune, siendo en los países desarrollados la segunda causa de discapacidad entre personas jóvenes después de los accidentes de tráfico. Durante los últimos años se han desarrollado, o actualmente están en ensayo clínico, una gran cantidad de fármacos para tratar esta patología. Entre todos ellos cabe destacar natalizumab, u...

  17. Chemical variations observed in irradiated, treated with IPC and control potato tubers; Variaciones quimica observadas en tuberculos de patata irradiados, tratados con IPC y testigo

    Energy Technology Data Exchange (ETDEWEB)

    Mazon Matanzo, M P; Fernandez Gonzalez, J

    1976-07-01

    The content in soluble sugars, ascorbic acid and phenolic acids of potato tubers preserved by irradiation and IPC, during storage period of five months are studied. In the irradiated tubers, soluble sugars increased immediately after the irradiation, in relation to the control tubers reaching inferior values to those reached by the control tubers, at the end of the storage period. The content in ascorbic acid is generally kept higher in the irradiated and IPC treated tubers than in the control tubers and the content in phenolic acids increased in the irradiated and IPC treated tubers by immediate effect of this treatment. (Author) 39 refs.

  18. Reversión del fenotipo obeso en ratones tratados con AAV9 que expresan la carnitina palmitoiltransferasa 1A humana en hígado

    OpenAIRE

    Weber Blattes, Minéia

    2016-01-01

    [spa] La obesidad es una enfermedad crónica de origen multifactorial y se caracteriza por una acumulación excesiva de grasa en todo el organismo. La obesidad y los transtornos metabólicos asociados, como son la resistencia a la insulina, la diabetes mellitus tipo 2, la enfermedad cardiovascular, el cáncer y otras patologías, se han convertido en un grave problema de salud pública del siglo XXI. En los últimos años se está realizando un gran esfuerzo para entender los mecanismos fisiopatológi...

  19. Contribución al estudio de las modificaciones estructurales y ultraestructurales en branquias, en su zona respiratoria y sensitiva, en zebrafish (Danio rerio) tratados con dioxina

    OpenAIRE

    Navas Lloret, José Miguel

    2017-01-01

    Desde mediados del siglo XX ha ido aumentando la preocupación acerca de los efectos de los llamados disruptores endocrinos, efectos que se pueden apreciar en todas las especies animales, incluso en el hombre. Hacemos un recordatorio de características de estos disruptores endocrinos, su naturaleza y sus efectos sobre el medio ambiente, así mismo damos una visión de las actuaciones al respecto de la industria química. Para este estudio se utilizaron 120 individuos de de pez zebrafish (Da...

  20. Videojuego con Realidad Virtual

    OpenAIRE

    González Mora, César

    2017-01-01

    El objetivo del proyecto es el desarrollo de un videojuego deportivo que utilice realidad mixta. El videojuego se podrá utilizar con dispositivos de tipo cardboard, y utilizará realidad aumentada para la interacción del jugador con el videojuego. En el desarrollo se utilizará el motor Unity para conseguir una aplicación multiplataforma, y la librería Vuforia para implementar realidad mixta.

  1. Sistemas integrados con Arduino

    OpenAIRE

    EL YAKOUTI, MOHAMMED

    2017-01-01

    Design of a robot prototype remotely controllable from Bluetooth using Arduino. Control and testing of sensors and events interacting with Arduino and Bluetooth. Diseño de un prototipo de robot controlable remotamente con Bluetooth utilizando Arduino. Control y verificación de los sensores y eventos que interactúan mediante el Arduino y el Bluetooth. El Yakouti, M. (2017). Sistemas integrados con Arduino. http://hdl.handle.net/10251/89274. TFGM

  2. Characterization and comparison of proteomes of albino sea cucumber Apostichopus japonicus (Selenka) by iTRAQ analysis.

    Science.gov (United States)

    Xia, Chang-Ge; Zhang, Dijun; Ma, Chengnv; Zhou, Jun; He, Shan; Su, Xiu-Rong

    2016-04-01

    Sea cucumber is a commercially important marine organism in China. Of the different colored varieties sold in China, albino sea cucumber has the greatest appeal among consumers. Identification of factors contributing to albinism in sea cucumber is therefore likely to provide a scientific basis for improving the cultivability of these strains. In this study, two-dimensional liquid chromatography-tandem mass spectrometry coupled with isobaric tags for relative and absolute quantification labeling was used for the first time to quantitatively define the proteome of sea cucumbers and reveal proteomic characteristics unique to albino sea cucumbers. A total of 549 proteins were identified and quantified in albino sea cucumber and the functional annotations of 485 proteins have been exhibited based on COG database. Compared with green sea cucumber, 12 proteins were identified as differentially expressed in the intestine and 16 proteins in the body wall of albino sea cucumber. Among them, 5 proteins were up-regulated in the intestine and 8 proteins were down-regulated in body wall. Gene ontology annotations of these differentially expressed proteins consisted mostly of 'biological process'. The large number of differentially expressed proteins identified here should be highly useful in further elucidating the mechanisms underlying albinism in sea cucumber. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. Role of lutein in alleviating the effects of electron beam radiation induced hematological and biochemical changes in Swiss albino mice

    International Nuclear Information System (INIS)

    Vidya, V.; Krishna, A.P.; Patil, Shrikant; Fernandes, Ronald

    2016-01-01

    Lutein is a naturally occurring xanthophyll pigment derived from α-carotene. It is abundantly present in Tagetes erecta L. (marigold) and also present in a few vegetables, fruits and in animal sources. Lutein was evaluated for its protective role in electron beam radiation induced damages in Swiss albino mice. The drug was optimized for its radioprotective activity

  4. Evaluación de una crema dental con extracto de cuproclorofila

    Directory of Open Access Journals (Sweden)

    Estela Gispert Abreu

    2001-12-01

    Full Text Available Se evaluó el efecto del cepillado con crema dental que contiene extracto de cuproclorofila en 23 niños de 10 años (otros 23 niños se tomaron como control. Se observaron reducciones significativas según chi cuadrado en cuanto a la infección por Streptococcus mutans, la acumulación de placa dentobacteriana y en la inflamación gingival del grupo tratado con respecto al control.The effect of tooth brushing with a dentrifice containing cuprochlorophyll extract in 23 children aged 10 (other 23 were selected as controls was evaluated. Significant reductions were observed according to Chi square test as regards the infection caused by Streptococcus mutans, the accumulation of bacterial plaque and the gingival inflammation of the group treated compared with the controls.

  5. Modulatory influence of Aloe vera against radiation and cadmium induced hepatic lesions in Swiss albino mice

    International Nuclear Information System (INIS)

    Harsha, Radha; Purohit, R.K.

    2012-01-01

    The major objectives in radiobiology has been the development of agents that can mitigate the damage produced by ionizing radiation to normal tissues and thus reduces the side effects caused by radiation and improvement of cancer radiotherapy. The various agents have drawn attention of researchers as they provide wider acceptability and least side effects. The current study was aimed to investigate the protective effect of Aloe vera against radiation and cadmium induced changes in the liver of Swiss albino mice. For the study healthy male Swiss albino mice (6 to 8 weeks old) were selected from an inbred colony and kept in polypropylene cages. They were provided with standard mice feed and tap water ad libitum. The animals were exposed to 3.0 and 6.0 Gy of gamma radiation with or without cadmium chloride treatment. The animals of experimental groups were administered Aloe vera juice seven days prior to irradiation or cadmium chloride treatment. The animals of each group were autopsied at each post treatment interval of 1, 2, 4, 7, 14 and 28 days of treatment. The various biochemical parameters estimated were total proteins, glycogen, cholesterol, acid and alkaline phosphatase activities, DNA and RNA. After routine procedure, histopathological changes were also observed. The changes in various biochemical parameters were observed in the form of increase of decrease in values. The histopathological changes observed on day-1 after exposure to 3.0 Gy were distortion of hepatic architecture, intracellular oedema, narrower sinusoids, cytoplasmic degranulation, vacuolation and pycnotic nuclei. The changes were more marked on day-4 and continued up to day-14. But on day-28 the sign of recovery was observed. After exposure to a higher dose (6.0 Gy) similar changes were noticed but they were more pronounced and there was late manifestation of recovery. In the combined treatment of radiation and cadmium chloride synergistic effects were observed. The liver of Aloe vera treated

  6. Microbiome of the pre-epithelial biofilm of the colon of albino rats with experimental thyrotoxicosis

    Directory of Open Access Journals (Sweden)

    L.I. Sydorchuk

    2017-11-01

    Full Text Available Background. The microbiome of the pre-epithelial biofilm of the large intestine in direct contact with the body also interacts with the immune and other systems that emphasizes the urgency of its study in various diseases. The purpose of the study was to determine the taxonomic composition, population level, analytical microecological indicators and the degree of microecological disorders of the pre-epithelial biofilm of the large intestine in albino rats with thyrotoxicosis. Materials and methods. Experiments were carried out on 25 mature male albino rats weighing 220–240 g, of which 15 animals were included to the control group (intact animals, and 10 rats — to the main group. The experimental thyrotoxicosis was simulated by intragastric administration of L-thyroxine for 14 days. Under sterile conditions, a laparotomy was performed, a segment (up to 3 cm of the large intestine with its contents was taken. The washed portion of the intestine was homogenized with a sterile 0.9% NaCl solution. A series of ten-fold dilutions with 10–2 to 10–7 concentrations of the initial mixture were prepared. From each tube, 0.01 ml were seeded on solid optimal nutrient media with subsequent isolation and identification of microbes according to morphological, tinctorial, cultural and biochemical properties. Results. In some animals, bifidobacteria and lactobacilli, as well as bacteroides and escherichia, are eliminated. A significant deficiency of not only bifidobacteria by 48.50 % and lactobacillus by 94.59 %, but also of bacteroides by 44.85 % was established. Determination of the quantitative dominance of each taxon showed that the dominant role of bifidobacteria in the microbiocenosis is reduced by 82.76 %, lactobacillus — by 2.20 times, and the role of bacteroides in the microbiocenosis of the epithelial biofilm of the large intestine of albino rats with the experimental thyrotoxicosis — by 43.04 %, E.coli — by 7.18 %, but the role of

  7. Investigando con personas con dificultades de aprendizaje

    Directory of Open Access Journals (Sweden)

    Borja González Luna

    2013-12-01

    Full Text Available El artículo muestra los orígenes de lo que Walmsley (2008 denomina «investigación inclusiva». Para comprender qué se entiende por investigación inclusiva tenemos que remontarnos a los debates epistemológicos sobre las metodologías cuantitativas y cualitativas, acontecidos en la década de los 90, en torno a la revista Disability & Society. A partir de una síntesis de dichos debates, focalizados en el ámbito de la «discapacidad intelectual y del desarrollo», se exponen dos estrategias de colaboración con dicha población: a una aproximación etnográfica (de trabajo grupal, y b una aproximación biográfica (de trabajo individual. A continuación se esboza un posible diseño de trabajo de campo que intenta superar el paradigma cualitativo «clásico» con el objetivo de incluir a dicho colectivo más allá del rol de «sujetos de la investigación». Para finalizar se recoge el debate sobre la accesibilidad de los resultados de la investigación a los participantes en dichas investigaciones, y con ello la necesaria innovación en el ámbito de las «devoluciones» de los resultados, cuando se trata de incluir a personas que presentan limitaciones para la comprensión del lenguaje abstracto oral y/o escrito.

  8. Propiedades biomecánicas de la membrana limitante interna tras recibir tratamiento intravítreo con ocriplasmina.

    Science.gov (United States)

    Vielmuth, Franziska; Schumann, Ricarda G; Spindler, Volker; Wolf, Armin; Scheler, Renate; Mayer, Wolfgang J; Henrich, Paul B; Haritoglou, Christos

    2017-01-01

    Objetivo: Evaluar la rigidez de la membrana limitante interna (MLI) humana y evaluar los posibles cambios de las propiedades mecánicas tras administrar una inyección intravítrea de ocriplasmina para tratar la tracción vitreomacular. Métodos: Este estudio se compone de una serie de casos intervencionales y comparativos de 12 muestras de MLI extraídas mediante cirugía y obtenidas de forma consecutiva de 9 ojos de 9 pacientes después de someterse sin éxito a vitreólisis farmacológica con ocriplasmina. Durante el mismo periodo de tiempo, 16 muestras de otros 13 ojos sin tratamiento con ocriplasmina se obtuvieron mediante vitrectomía y sirvieron como controles. Todos los pacientes presentaron agujeros maculares o tracción vitreomacular y se sometieron a vitrectomía con disección de la MLI tanto con tinción con azul brillante (AB) como sin ella. Todas las muestras se analizaron con un microscopio de fuerza atómica con imágenes de las regiones de 25 × 25 μm. En todas las muestras, se analizaron tanto la parte de la retina como la del vítreo de la MLI. Resultados: La microscopia de fuerza atómica no reveló diferencias significativas en cuanto a elasticidad de las muestras de MLI extraídas de ojos con o sin tratamiento con ocriplasmina. Las áreas onduladas de la parte de la retina presentaron una mayor rigidez que la parte del vítreo de la MLI. La cartografía topográfica tanto de la parte del vítreo como de la retina de la MLI no mostró ninguna alteración aparente de la morfología en ojos tratados con ocriplasmina en comparación con los ojos no tratados. La tinción con azul brillante conllevó un aumento de la rigidez tisular. Conclusiones: Las inyecciones intravítreas de ocriplasmina no varían las propiedades biomecánicas de la MLI humana. No existen pruebas de un posible efecto enzimático que interfiera con la rigidez de esta membrana basal. © 2017 S. Karger AG, Basel.

  9. Evaluación urodinámica con doxazocina en pacientes con hiperplasia prostática benigna (HPB. Hospital Pablo Tobón Uribe (HPTU de 1998-1999

    Directory of Open Access Journals (Sweden)

    Juan Aristizábal

    2001-04-01

    Full Text Available

    Tradicionalmente la HPB ha sido tratada quirúrgicamente, pero a
    partir de los años 80 ha aparecido una gran variedad de modalidades
    terapéuticas diferentes a la cirugía, basadas en medicamentos orales que disminuyen el tamaño de la próstata y/o los síntomas que esto genera.
    Se propone estudiar con todos los parámetros urodinámicos, la respuesta de los pacientes con HPB tratados con Doxazocina para evaluar su efecto en las curvas Flujo-Presión.

     

     

  10. Modelo conceptual de datos difusos de triaje para emergencia hospitalaria representado con FuzzyEER

    Directory of Open Access Journals (Sweden)

    Wuilfredo Rangel

    2010-05-01

    Full Text Available El triaje de emergencia persigue desarrollar el proceso de valorización clínica preliminar para ordenar los pacientes según el nivel de urgencia o gravedad, antes de la atención médica, de forma que en una condición de saturación del servicio o disminución de recursos, los pacientes más graves sean tratados con prioridad. Un proceso de triaje presenta un alto grado de imprecisión o incertidumbre al momento de expresar el estado de salud de un paciente, en consecuencia puede haber dificultad y riesgo en la clasificación de las urgencias. En los servicios de emergencias de loshospitales públicos venezolanos, en especial el servicio de emergencia del Hospital Universitario de Caracas (HUC, seha evidenciado un incremento en el número de casos que se atienden, siendo una constante la saturación del servicio, lo cual imposibilita que los pacientes con prioridad de atención, sean tratados más rápidamente de forma oportuna y eficaz. En este trabajo se propone un modelo conceptual de datos difuso de triaje para el sector salud venezolano basado en el proceso de triaje hospitalario de la Sociedad Venezolana de Medicina de Emergencia y Desastres (SVMED, ya que un modelo de datos que contemple la representación de atributos difusos puede representar de mejor forma los requerimientos del sistema. El modelo propuesto utiliza la notación Entidad Relación con elementos difusos (FuzzyEER para la representación de las entidades y atributos con imprecisión. Dicho modelo será la base de un sistema automatizado de triaje que hará uso del lenguaje de consultas difusas FSQL (Fuzzy SQL.

  11. Os desafios do Brasil na implementação do Tratado sobre o Comércio de Armas (2013 - 2016)

    OpenAIRE

    Frota, Luiz Phelipe Pimenta

    2016-01-01

    Trabalho de Conclusão de Curso apresentado ao Instituto Latino-Americano de Economia, Sociedade e Política da Universidade Federal da Integração Latino-Americana, como requisito parcial à obtenção do título de Bacharel em Relações Internacionais e Integração. Orientador: Prof. Dr. Gustavo Oliveira Vieira O presente trabalho tem por objetivo analisar a posição da política externa do Brasil em relação ao Tratado sobre Comércio de Armas - TCA. Este tratado, que foi propos...

  12. A Recepção dos Tratados Internacionais em Matéria Tributária pelo Ordenamento Jurídico Brasileiro

    OpenAIRE

    Bianca Castellar de Faria

    2006-01-01

    A presente dissertação objetiva analisar a forma de recepção dos tratados internacionais em matéria tributária pelo ordenamento jurídico brasileiro. Para isso, é fundamental verificar a relação entre o direito internacional e o direito interno, por meio da análise das teorias monista e dualista. Apresenta-se o Direito Tributário Internacional como uma das variações do Direito Internacional Público, com o objetivo de introduzir a matéria tributária. Estudam-se os tratados como uma das principa...

  13. Tratados y recetarios de técnica industrial en la España medieval. La Corona de Castilla, siglos XV - XVI

    OpenAIRE

    Criado Vega, Teresa

    2013-01-01

    El eje de esta tesis es analizar las técnicas industriales en la Corona de Castilla en la Baja Edad Media, a través de los recetarios y tratados técnicos localizados en distintas bibliotecas hispanas, como prueba evidente de que tales conocimientos no se transmitieron de forma oral únicamente, sino que fueron recogidos de forma escrita. Esta es una realidad constatada en el resto de Europa, donde han sido estudiados diversos recetarios y tratados, algunos de los cuales han sido utilizados par...

  14. Asociación de colelitiasis y terapia de reemplazo de testosterona en un paciente con hipogonadismo primario

    OpenAIRE

    S. Squarza; U.G. Rossi; P. Torcia; M. Cariati

    2018-01-01

    Resumen: Tratamos a un niño de 16 años de edad con hipogonadismo primario debido a la anorquia bilateral, que presentó cálculos biliares en la vesícula biliar con una leve dilatación del árbol biliar intrahepático. La histología de los cálculos biliares confirmó la naturaleza de colesterol de los mismos. El niño fue tratado desde la infancia con terapia de reemplazo de testosterona. Sugerimos una posible correlación entre la terapia de reemplazo de testosterona y la presencia de cálculos bili...

  15. Las convenciones de comercio, navegación y relaciones internacionales firmadas por Colombia con Estados Unidos y Reino Unido en 1825: al rescate de su memoria, a propósito del TLC

    Directory of Open Access Journals (Sweden)

    Jorge Enrique Elías Caro

    2013-10-01

    Full Text Available Colombia en 1825 firmó con Estados Unidos y el Reino Unido un tratado de libre comercio, de navegación y relaciones internacionales. En este trabajo lo que se persigue es explicar las razones que dieron origen a la firma de estos acuerdos. De igual forma analizar las repercusiones que tuvo para la economía, la política y las condiciones sociales el haber suscrito estos pactos. De la misma manera se hace una analogía de los determinantes que versaban estos tratados con el que actualmente vienen  los gobiernos de Colombia y Estados , para ello se hace una comparación de los articulados y sus contenidos

  16. Lead nitrate induced unallied expression of liver and kidney functions in male albino rats.

    Science.gov (United States)

    Chougule, Priti; Patil, Bhagyashree; Kanase, Aruna

    2005-06-01

    To determine the effects of lead where lead accumulates maximum (liver followed by kidney), liver and kidney functions were studied using low oral dose of lead nitrate for prolonged duration. Dose of 20 mg lead nitrate/kg body wt/day was used in male albino rats. AST and ALT levels altered independently. When ALT remained unaltered after 7 and 21 days of treatment, it is decreased by 13.21% after 14 days treatment. AST was marginally lowered after 7 days, increased after 14 days and increased marginally after 21 days. Bilirubin (conjugated, unconjugated and total) decreased after 7 and 14 days and increased after 21 days. Urea increase was directly proportional to duration. Creatinine remained unaltered.

  17. Distribution and excretion of. cap alpha. -naphthylthio-(/sup 14/C)urea in Albino rats

    Energy Technology Data Exchange (ETDEWEB)

    Patil, T N; Radhakrishnamurty, R [Central Food Technological Research Inst., Mysore (India)

    1977-09-01

    ..cap alpha..-naphthylthio-(/sup 14/C) urea was synthesised by allowing potassium (/sup 14/C)thiocyanate to react with ..cap alpha..-naphthylamine. Its distribution and excretion were studied in Albino rats following the administration of this rodenticide. Considerable radioactivity observed in liver and kidney, increased till 8 hr and later decreased. About 80% of the activities present in serum and pleural effusion were found in the respective albumin fractions. Approximately 40% of the dose administered was excreted in urine and less than 1% in faeces in 20 hr. About 36% of the total urinary activity was recovered as unchanged compound and the rest was distributed in three metabolites with low Rsyb(f) values. Decrease in cytochsome P-450 content and activities of N, N-dimethylaniline demethylase, aryl 4-hydroxylase and reduced NAD dehydrogenase were observed in ..cap alpha..-naphthylathiourea-treated rats.

  18. Distribution and excretion of α-naphthylthio-[14C]urea in Albino rats

    International Nuclear Information System (INIS)

    Patil, T.N.; Radhakrishnamurty, R.

    1977-01-01

    α-naphthylthio-( 14 C) urea was synthesised by allowing potassium ( 14 C)thiocyanate to react with α-naphthylamine. Its distribution and excretion were studied in Albino rats following the administration of this rodenticide. Considerable radioactivity observed in liver and kidney, increased till 8 hr and later decreased. About 80% of the activities present in serum and pleural effusion were found in the respective albumin fractions. Approximately 40% of the dose administered was excreted in urine and less than 1% in faeces in 20 hr. About 36% of the total urinary activity was recovered as unchanged compound and the rest was distributed in three metabolites with low Rsyb(f) values. Decrease in cytochsome P-450 content and activities of N, N-dimethylaniline demethylase, aryl 4-hydroxylase and reduced NAD dehydrogenase were observed in α-naphthylathiourea-treated rats. (author)

  19. Environmental toxicology: Acute effects of suspended particulate matter (dust on hematological indices of albino rats

    Directory of Open Access Journals (Sweden)

    V.O. Ogugbuaja

    2004-12-01

    Full Text Available The elemental contents of suspended particulate matter (dust samples from Maiduguri, Nigeria, were determined which showed appreciably high levels for especially Pb, Fe, Cu, Zn, K, Ca, and. Na. Wister albino rats were exposed to graded doses of phosphate buffered saline carried dust particles. The hematological indices of the exposed rats were examined on days 10, 20, 30, and 60 post administrations. White blood cell, red blood cell and hemoglobin counts peaked between days 20 and 30. This observation was markedly so for the higher doses, 1000 and 2000 mg/kg, in contrast to the 500 mg/kg dose. The platelet count however indicated a gradual increase within the study period. Observed changes for these indices from the control values were found significant at 99% confidence level. Possible inhalatory problems are thus anticipated from prolonged accumulation of the dust in the respiratory system.

  20. Inheritance of a new albino mutation in Brazilian free-range black chickens

    Directory of Open Access Journals (Sweden)

    W Jorge

    2008-09-01

    Full Text Available A genetically recessive albino mutation, which inhibits pigment development in the eyes, skin, and feathers of domestic chickens from Brazil, is described. This mutation appeared in a flock of completely black chickens of a private breeder. There are no information on the origin, breed, or specific line of the birds. Pigment inhibition is apparently complete in the feathers and eyes. Bird sight is very impaired, but no histological examination was carried out. Ratios obtained in F2 and backcrossed birds indicate that a single autosomal recessive gene is responsible for the condition. The data suggest that the absence of melanin in the eyes, skin, and feathers (symbol cc is a mutation of the pigmented C wild gene.

  1. Salty solutions: their effects on thermal set points in behavioral repertoires of albino rats.

    Science.gov (United States)

    Vitulli, W F; Aker, R; Howard, S W; Jones, W M; Kimball, M W; Quinn, J M

    1994-08-01

    Salt (sodium chloride) has been linked to increased blood pressure and a rise in core body temperature. The objective of this study was to investigate the role played by salt in altering behavioral thermoregulation in albino rats. Different doses of sodium chloride were administered (ip) prior to fixed-interval 2-min. schedules of microwave reinforcement in rats tested in a cold Skinner Box. Three Sprague-Dawley rats were conditioned to regulate their thermal environment with 5-sec. exposures of MW reinforcement in a repeated-measures reversal design. Friedman's non-parametric test showed significant differences among sodium chloride doses and physiologically normal saline. Post hoc sign tests showed that all doses of NaCl suppressed operant behavior for heat except 60 mg/kg. The hypothesis that sodium chloride lowers hypothalamic set point for heat was partially supported.

  2. Development of spermatic granuloma in albino rats following administration of water extract of Heliotropium bacciferum Forssk.

    Science.gov (United States)

    Alanazi, Khalid; Alahmadi, Bassam A; Alhimaidi, Ahmed; Abou-Tarboush, Faisal M; Farah, Mohammad Abul; Mahmoud, Ahmed; Alfaifi, Mohamed

    2016-01-01

    A spermatic granuloma is a chronic inflammatory reaction produced in response to extravasated sperm within the intertubular connective tissue. The present study investigates the possible toxic effects of water extract of Heliotropium bacciferum on the reproductive system of male albino rats and the associated potential for the development of spermatic granulomas. H. bacciferum is a herbal plant used in traditional medicine and reported to have cytotoxic effects due to pyrrolizidine alkaloids. Histological examinations revealed no changes in the tissues of the testes, although, some changes were detected in the cauda epididymis, the most important of which was the development of small lesions of spermatic granulomas. Clear gaps were observed between the epithelial linings of the epididymal tubules.

  3. Harmful effect of protein difficiency on lipids, glucose, insulin and estradiol levels in female albino rats

    International Nuclear Information System (INIS)

    El-Mahdy, A.A.; El-Sherbiny, E.M.; Bayomi, M.M.

    2005-01-01

    The present study was undertaken to investigate the harmful effect of protein deficient diet on some biochemical activities in serum of female rats. Protein malnutrition is a well known socioeconomic problem in different parts of the world. Many studies were investigated on the biological parameters following protein malnutrition in human and experimental animals. Forty albino female rats were divided into 3 groups. The first group (10 rats) fed 18% protein diet and served as normal control and the other two groups, each contains 15 rats, fed 5% protein for 21 and 45 days, respectively, and served as malnourished groups. The results showed significant decrease in total body weight, serum glucose, insulin and estradiol levels in the third group as well as decrease in the total cholesterol, HDL-cholesterol, LDL-cholesterol and VLDL-cholesterol and triglycerides concentrations that compared to normal control rats

  4. Diuretic activity of Linaria ramosissima (wall.) Janch. leaves in albino rats

    Science.gov (United States)

    Pandya, Preeti N.; Aghera, Hetal B.; Ashok, B. K.; Acharya, Rabinarayan

    2012-01-01

    Linaria ramosissima (Wall.) Janch., Scrophulariaceae, a folklore plant, has been claimed for its diuretic activities by traditional practitioners. The present study was undertaken to investigate the diuretic activity of L. ramosissima leaves in albino rats. Suspension of leaf powder in 2% gum acacia was administered to experimental rats orally at doses of 450 mg/kg. The diuretic effect was evaluated by measuring the urine volume, pH of urine, and urinary electrolyte excretion. Administration of the test drug increased the urine volume in a non-significant manner, while it enhanced the urinary excretion of sodium, chloride, and potassium significantly, in comparison to the control group. From the present study it can be concluded that the leaves of L. ramosissima have a significant diuretic activity. PMID:23723679

  5. Lead Intoxication On Protein Fractions, Testicular Tissues And Ameliorative Effect Of ANTOX On Male Albino Rats

    International Nuclear Information System (INIS)

    HASSANIN, M.M.; EL-MAHDY, A.A.; ZAKI, Z.T.; EMARAH, E.A.M.; HUSSEIN, A.M.M.

    2010-01-01

    Lead (heavy metal) was given as lead acetate for two groups of adult male albino rats (Rattus rattus) in drinking water at dose level of 100 mg/litre for 3 and 6 weeks to evaluate its toxic effects on protein and its fractions by using electrophoresis technique, serum testosterone using radioimmunoassay and histological investigation of the testis of male rats.Administration of 100 mg/L lead acetate in drinking water for 3 and 6 weeks induced fluctuated changes in serum total proteins, protein fractions and significant decrease in serum testosterone hormone.Histopathological examination showed cellular changes and degeneration of the seminiferous tubules after 3 and 6 weeks of administration of lead acetate.The treatment of rats with antox (10 mg/kg) during the experimental period caused improvement in protein fraction and testosterone level, and the testes sections appeared more or less normal.

  6. Role of antioxidant supplements in adult male albino rats intoxicated with methomyl

    International Nuclear Information System (INIS)

    Tawfik, S.M.F.M.; EI-Sherbiny, E.M.; Afifi, E.A.A.

    2007-01-01

    The present investigation was undertaken to evaluate and determine the protective effect of intraperitoneal administration of trace mineral selenium (Se) and antioxidant vitamins E and pantothenic acid (PA) to male albino rats intoxicated with methomyl pesticide. Four groups of rats were used in this study. The data obtained revealed that methomyl caused disturbances in liver functions, which were elucidated through ALT and AST levels, and in the levels of serum glucose and insulin. Also, the levels of serum total protein, albumin, total lipids, triglycerides, cholesterol and acethylcholinesterase activity were significantly changed from those found in control rats for different periods. Treatment of rats with the antioxidant supplements ameliorated to some extent most of the disturbances in the mentioned biochemical parameter levels. The data concluded that such antioxidants could provide some protection against pesticide-induced toxicity

  7. Correction of glutathione metabolism in the liver of albino rats affected by low radiation doses

    International Nuclear Information System (INIS)

    Moiseenok, A.G.; Slyshenkov, V.S.; Khomich, T.I.; Zimatkina, T.I.; Kanunnikova, N.P.

    1997-01-01

    The levels of total glutathione GSH, GSSG and the activities of glutathione reductase and glutathione peroxidase were studied in the liver of adult albino rats subjected to 3-fold external γ-irradiation throughout 2 weeks at the overall dose of 0.75 Gy after 15 h, 2 and 5 days from the last irradiation. Some animals were injected intraperitoneally with the pantothenate containing complex > 3 times on days 1-3 before the irradiation. The radiation related decrease of GSH, GSH/GSSG and the total glutathione level was prevented by the prophylactic administration of the complex and probably at the expense of the activation of the G-SH biosynthesis and/or transport in the liver by the CoA biosynthetic precursor. (author)

  8. In utero exposure to radiation and mercury in swiss albino mice

    International Nuclear Information System (INIS)

    Kumar, A.; Ramanan, K.

    1992-01-01

    Ionizing radiation and heavy metals may interfere seriously with embryonic or fetal development. Embryotoxic effects of radiation as well as heavy metals comprising lethality, growth retardation and specific patterns of malformation have been presented in various reviews and symposia. Very few studies have been performed so far on the combined effects of radiation and metals on prenatal development, especially skeletal development. This study investigates interaction between ionizing radiation and methylmercury (heavy metal) in the embryo of swiss albino mice during the late organogenetic (9 or 11 d.p.c.) and early fetal period (14 d.p.c.) of development which stages represent a good model to examine the effects of various stresses at a minimum dose/concentration. (author). 20 refs., 1 tab

  9. Aloe vera gel provides protection to Swiss albino mice against radiation induced injury

    International Nuclear Information System (INIS)

    Saini, D.K.; Chaudhary, G.; Saini, M.R.

    2007-01-01

    Aloe gel powder was administered orally to Swiss albino mice at the dose of 250, 500 and 750 mg/kg body weight/day for 15 consecutive days with and without irradiation with 8 Gy to find out its maximum effective radioprotective dose. 30 days survivality and change in levels of lipid peroxidation (LPO), reduced glutathione (GSH) and vitamin C were studied at 1 hour and 30 days for this purpose. In Aloe treated (750 mg/kg b. wt.) 8 Gy irradiated animals 30 days survivality, contents of GSH and vitamin C were higher and LPO level was lesser at 1 hour and 30 days in comparison to those treated with Aloe at the dose of 250 and 500 mg/kg body weight and irradiated with 8 Gy. These results indicate that Aloe administration at the dose of 750 mg/kg body weight was found to be the most effective

  10. Effect of salvia Egyptiaca extract on cholinergic system in adult male albino rats

    International Nuclear Information System (INIS)

    Abdel Kader, S.M.

    2004-01-01

    The daily oral administrations of Salvia aegyptiaca extract, equivalent to 2 g/kg body weight for 4 weeks, caused significant decrease in acetylcholine esterase activity in whole blood and in all tested brain areas (cerebellum, pons + medulla oblongata, striatum, cerebral cortex, hypothalamus, midbrain and hippocampus) of male albino rat nearly all over the experimental period. Treatment with Salvia aegyptiaca extract also resulted in significant increase in acetylcholine content in the cerebral cortex and hippocampus' nearly throughout the whole experimental period. It could be concluded from the present results that the extract of Salvia aegyptiaca caused an increase in acetylcholine content and this increase may be due to the decrease in the activity of acetylcholine esterase enzyme which play an important role in the treatment of Alzheimer's disease

  11. Analgesic activity of Nelsonia canescens (Lam.) Spreng.root in albino rats

    Science.gov (United States)

    Mohaddesi, Behzad; Dwivedi, Ravindra; Ashok, B. K.; Aghera, Hetal; Acharya, Rabinarayan; Shukla, V. J.

    2013-01-01

    Present study was undertaken to evaluate analgesic activity of root of Nelsonia canescens (Lam.) Spreng, a folklore medicinal plant used as the one of the source plant of Rasna. Study was carried out at two dose levels (270 mg/kg and 540 mg/kg) in albino rats. Analgesic activity was evaluated in formalin induced paw licking, and tail flick methods whereas indomethacin and pentazocine were used as standard analgesic drugs, respectively. At both the dose levels, test drug non-significantly decreased paw licking response at both time intervals. In tail flick model, the administration of the test drug increased pain threshold response in a dose dependent manner. In therapeutically equivalent dose level, analgesic activity was observed only after 180 min while in TED ×2 treated group analgesia was observed at 30 min and lasted even up to 240 min. The results suggested that N.canescens root possess moderate analgesic activity. PMID:24250136

  12. Macroscopic description of the coronary arteries in Swiss albino mice (Mus musculus

    Directory of Open Access Journals (Sweden)

    A. Yoldas

    2010-05-01

    Full Text Available A total of 25 (13 male, 12 female adult, healthy Swiss albino mice were used to investigate the origin, course and anastomoses of coronary arteries. Coloured latex was injected into the aortic arch to enable these arteries to be clearly discerned. A. coronaria sinistra was larger than A. coronaria dextra. It was divided into a Ramus interventricularis paraconalis and a Ramus circumflexus sinister. However, in 2 specimens, the septal ramus, was observed to stem directly from the left coronary artery, and only 1 ventricular branch arose from the left circumflex. The collateral branches of the paraconal interventricular ramus had a larger diameter and more extensive distribution was observed in these specimens. The A. coronaria dextra was divided into a Ramus septalis and Ramus circumflexus dexter. The Ramus interventricularis subsinuosis was not detected in this study. The ventricular branches of the left coronary artery run intramyocardially whereas the branches of the right coronary artery course subendocardially.

  13. Histological Study of the Effect of Aluminum in Testes of Albino Mice

    Directory of Open Access Journals (Sweden)

    Abdul-Hadi Abbas Hadi

    2013-11-01

    Full Text Available Aluminum is widely distributed and constitutes approximately 8.8% of the earth's crust and considers as potential toxin in the environment, especially when present in high concentrations. This study sought to study the effects of subcutaneous injection of aluminum chloride on the histological structure of testes of the albino mice and comprises the effect at concentrations of 80, 160, 240, 320, and 400 mg/kg body weight. Increasing degree of damage of testicular tissue in correlation with the number and the amount of doses of aluminum chloride such as diffusion of oedematous fluid in the tissues, congestion of blood vessels, pyknosis of nuclei and an increase in the number of giant cells were the prominent histopathological changes.

  14. Interaccion de promastigotes de Leishmania donovani con celulas de exudado peritonial de ratones mediante la influencia de la quimotripsina

    Directory of Open Access Journals (Sweden)

    Lucila Arcay

    1986-06-01

    Full Text Available Se hace un estudio de la interacción de promastigotes de Leishmania donovani con células de exudado peritoneal de ratón (c e p mediante la influencia de la quimotripsina. La adhesión de los promastigotes a las c e p fue terminal y marginal, y en observaciones hechas a partir de los 10 minutos de enfrentamiento, esta adhesión fue nula hasta los 30 minutos en el grupo tratado, y sólo a las das horas hubo un pequeño incremento (2.4% con respecto al control. Se observa marcada disminución en todos los parámetro medidos, tales como enlace, penetración, multiplicación intracelular, división de formas flageladas, en el grupo tratado. La quimotripsina favorece la formación de formas intermedias flageladas, heciendose el parásito piriforme y esférico, apareciendo una forma aberrante de extremo anterior cilindrico que semeja a una forma coanoflagelada. Se sospecha que la enzima reduce efectivamente fragmentos proteicos o péptidos, los cuales pueden haber sido tan pequeños como para esconder a otros ligandos relacionados con la adhesión macrófago-parásito.

  15. Creación de mapas conceptuales con CMapTools versión 4.02

    OpenAIRE

    Orlando Abril, Diego; Patricia Vivas, Nidia

    2005-01-01

    El presente artículo resume las principales actividades para elaborar un mapa conceptual con CmapTools, pero no pretende ser una guía completa de creación de mapas conceptuales ni tampoco un tratado de gramática para la definición de las proposiciones representadas en ellos. Aquest article resumeix les principals activitats per a elaborar un mapa conceptual amb CmapTools, però no pretén ser una guia completa de creació de mapes conceptuals ni tampoc un tractat de gramàtica per a la definic...

  16. El régimen colombiano de la contratación estatal frente al TLC con Estados Unidos

    OpenAIRE

    López Silva, Jorge Alberto

    2014-01-01

    El presente escrito desarrolla un análisis comparado entre el sistema de compras públicas colombiano y el Tratado de Libre Comercio suscrito con los Estados Unidos en cuanto a compras públicas se refiere, poniendo en evidencia inconsistencias de tipo jurídico para efectos principalmente prácticos, acudiendo a temas de soporte para el desarrollo de las obligaciones contenidas en el acuerdo, como son las Normas de Origen de los Bienes y el régimen de responsabilidad del contratista estatal colo...

  17. Via póstero-lateral unilateral para cifoplastia percutánea con balón

    OpenAIRE

    Ricciardi,Daniel Oscar

    2013-01-01

    Esta experiencia ha sido realizada en el Hospital Alvarez de Buenos Aires, Argentina en pacientes tratados por el Equipo de Columna Vertebral. El autor ha modificado el método original de punción descrito por Valls y Ottolenghi, lo que permite ubicar al paciente en decúbito lateral y prescinde del instrumental descrito originalmente, como spider y guía que se utilizaban con equipos de rayos X convencionales. El presente trabajo pretende describir en detalle la técnica aplicada para efectuar l...

  18. LA AGROINDUSTRIA AZUCARERA DE ARGENTINA Y LOS DESAFÍOS FRENTE AL PROCESODE INTEGRACIÓN CON BRASIL

    OpenAIRE

    Verón, Alejandro; Calvo, Clara

    2012-01-01

    Desde la firma del Tratado de Asunción que dio origen a la conformación del Mercado Común el Sur (Mercosur), se facilitó el intercambio comercial entre los países miembros y con ello la apertura de los mercados, sin embargo en la actualidad aún existen productos que continúan sin entrar en competencia, tal el caso del azúcar. Al respecto y desde un lugar común, la mayoría de las opiniones concuerdan que la integración en materia azucarera es inviable: las barreras arancelarias de Argentina co...

  19. Entrecruzamiento en medio acuoso del biomaterial pericárdico bovino con un prepolímero de poliuretano Entrecruzamiento en medio acuoso del biomaterial pericárdico bovino con un prepolímero de poliuretano

    Directory of Open Access Journals (Sweden)

    Birzabith Mendoza-Novelo

    2012-02-01

    Full Text Available Animal tissues used in the manufacture of medical devices require chemical treatments to improve durability. A number of techniques have been proposed to preserve such collagenous biological tissues. This study reports a new strategy for the crosslinking of bovine pericardium with a blocked polyurethane prepolymer (PUP in aqueous medium. The decrease in amino group content (70 % and corresponding increase in shrinkage temperature (13 °C when native tissue was treated with PUP, indicate the participation of tissue-amines in the stabilization process. The resistance toward degradation by collagenase in PUP-treated tissue indicate a in vitro stability similar to the glutaraldehyde-crosslinked tissue. It can conclude that the isocyanate-blocked PUP is effective agent for the aqueous fixation of biological tissues of biomedical interest.Los tejidos animales destinados a la fabricación de dispositivos médicos requieren de tratamientos químicos para mejorar su durabilidad. Varias técnicas se han propuesto para preservar tales tejidos biológicos ricos en colágeno. En este estudio se reporta una nueva estrategia para entrecruzar pericardio bovino (PB con un prepolímero de poliuretano (PUP soluble en agua con grupos isocianato protegidos. La disminución del contenido de grupos amino libres (70 % y el correspondiente incremento de la temperatura de encogimiento (13 °C para PB tratado con PUP, indican la participación de los grupos amino del tejido en el proceso de estabilización. La resistencia a la digestión con colagenasa de PB tratado con PUP indican una estabilidad in vitro similar al tejido entrecruzado con glutaraldehído. Se puede concluir que el PUP bloqueado es un agente efectivo para la fijación en medio acuoso de tejidos biológicos de interés biomédico.

  20. ANALGESIC ACTIVITY OF AQUEOUS EXTRACT OF CURCUMA AMADA (MANGO - GINGER IN MALE ALBINO WISTAR RATS

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    Kumari Bai

    2015-09-01

    Full Text Available BACKGROUND: Mango ginger ( Curcuma amada Roxb. has morphological resemblance with ginger, but imparts mango flavour. According to Ayurveda and Unani medicinal systems , the biological activities include antioxidant, antibacterial, antifungal, anti - inflammatory, antiallergic, CNS depressant and analgesic activity. Hence curcuma amada aqueous extract for analgesic activity was evaluated in pain animal models. Pain is a most common complaint of many medical conditions, and pain control is one of t he most important therapeutic priorities. Curcuma Amada suppresses the inflammatory mediators associated with pain. However there is no scientific data suggestive of its analgesic activity. Hence this study was carried out to evaluate its role in central a nd peripheral models of pain. OBJECTIVE: To Evaluate rhizomes of Curcuma Amada for analgesic activity in male albino wistar rats . MATERIALS AND METHODS: Albino rats, the proven models for analgesic studies. They were obtained from the animal house of DR.B. R. Ambedkar Medical College. Animals were maintained as per CPCSEA guidelines . The aqueous extract of curcuma amada was used.4x2 groups of 6 Rats were used to ensure that results obtained were statistically significant using ANOVA test. Analgesic activity was assessed with the help of following screening methods . Acetic Acid Writhing Method using Acetic Acid . Tail Flick Method using the Analgesiometer . Tail Immersion Method using Hot Water (55 0 C . Hot Plate method using Hot Plate . RESULT S: Aqueous extract of curcuma amada significantly suppressed the 1% acetic acid induced writhing response in rats when compared to control group (Gum acacia. In Tail flick test and Hot plate test Curcuma Amada increases the latency period of pain (reaction time. In Tail im mersion test the test drug significantly (P < 0.001 reduces pain at 30 min when compared to control group at 60 min of oral administration. CONCLUSION : The present findings indicate that

  1. Evaluation of Cholesterol-lowering Activity of Standardized Extract of Mangifera indica in Albino Wistar Rats.

    Science.gov (United States)

    Gururaja, G M; Mundkinajeddu, Deepak; Kumar, A Senthil; Dethe, Shekhar Michael; Allan, J Joshua; Agarwal, Amit

    2017-01-01

    Cholesterol lowering activity of Mangifera indica L. has been determined by earlier researchers and kernel, leaf and bark have shown significant activity. However, the specific cholesterol lowering activity of leaf methanol extract has not been determined. The present study involved evaluation of cholesterol lowering potential of methanol extract of M. indica leaves using high cholesterol diet model in albino Wistar rats. The acute oral toxicity at a dose of 5000 mg/ kg body weight was also determined in female albino Wistar rats. Phytoconstituents Iriflophenone 3-C-β-D-glucoside and mangiferin were quantified in methanol extracts of different varieties of mango leaves using high performance liquid chromatography. Significant cholesterol lowering activity was observed with methanol extract of M. indica leaves, at dose of 90 mg/kg body weight in rats and it was also found to be safe at dose of 5000 mg/kg rat body. Iriflophenone 3-C-β-D-glucoside and mangiferin were found to be in the range of 1.2 to 2.8% w/w and 3.9 to 4.6% w/w, respectively which along with 3 β taraxerol and other sterols could be contributing to the cholesterol lowering activity of mango leaves extract. The phytosterols rich extract of Mangifera indica leaves is a good source of nutraceutical ingredient that have the potential to lower serum cholesterol levels. The Mangifera indica leaves methanolic extract showed significant cholesterol lowering activity in high cholesterol diet induced hypercholesterolaemia model in rats when evaluated at a dose of 90 mg/kg rat body weight. The extract was found to contain Iriflophenone 3-C-β-D-glucoside and mangiferin which along with 3 β taraxerol and other sterols could be contributing to the cholesterol lowering activity.

  2. Nigella sativa oil Ameliorates ionizing Radiation induced cellular injury in Male Albino Rats

    International Nuclear Information System (INIS)

    Mohamed, E.T.; El-Kady, A.A.

    2013-01-01

    Nigella sativa (NS), commonly known as black seed, is a plant spices in which thymoquinone is the main active ingredient isolated from the black seeds. The seeds of Nigella sativa are used in herbal medicine all over the world for the treatment and prevention of a number of diseases. The aim of this study was focused on investigating the possible protective effect of NS against gamma radiation induced nephrotoxicity and inflammatory changes in male albino rats. Twenty four albino rats were divided into four equal groups as follows: control group, irradiated group (animals subjected to whole body gamma irradiation at a dose of 6 Gy), treated group (rats treated with 0.2 ml/kg, i.p., NS oil for 4 weeks), and treated irradiated group (animals treated with 0.2 mL/kg, i.p., NS oil for 4 weeks then exposed to whole body gamma irradiation at a dose of 6 Gy). The obtained results revealed that the administration of Nigella sativa oil to irradiated rats significantly ameliorated the changes induced in kidney antioxidant system; catalase and glutathione peroxidase activities as well as reduced glutathione concentration. Also, NS oil restored the kidney function indices (urea and creatinine) near normal level when compared with their equivalent values in irradiated rats. In addition, the changes in serum tumor necrosis factor alpha (TNF-α), Interleukin-1β (IL-1β) and Interleukin-6 (IL-6) activities were markedly improved compared to the corresponding values of irradiated group. The histopathological results showed distinctive pattern of ischemic renal injury in irradiated group, while in treated- irradiated group the renal tissues showed relatively well-preserved architecture with or without focal degeneration. In conclusion, NS acts in the kidney as a potent scavenger of free radicals to prevent or ameliorates the toxic effects of gamma irradiation as shown in the biochemical and histopathological study and also NS oil might provide substantial protection against

  3. Effects of aspartame on the evaluation of electrophysiological responses in Wistar albino rats

    Directory of Open Access Journals (Sweden)

    Arbind Kumar Choudhary

    2016-07-01

    Full Text Available Aspartame is a non-nutritive sweetener that is used predominantly in various ‘diet’ and ‘low-calorie’ products, such as beverages, instant breakfasts, desserts, breath mints, sugar-free chewing gum, vitamins, and pharmaceuticals, consumed by millions of people who are attempting weight loss, young adults and diabetic persons. On a weight basis, the metabolism of aspartame generates approximately 50% phenylalanine, 40% aspartic acid and 10% methanol. The detailed mechanisms of the effects of aspartame on the electrophysiological response are still unclear; therefore, this study was designed to clarify whether longer-term aspartame consumption has any effect on the electrophysiological response in Wistar albino rats. The oral administration of aspartame in a safe dose of 40 mg/kg bodyweight/day (as recommended by EFSA, 2012 was tested in Wistar albino rats for a longer period (90 days. Electrophysiological responses, including heart rate variability (HRV and electroencephalogram (EEG pattern, were assessed in a folate-deficient animal model along with control animals using BIOPAC and EEG equipment (model RMS EEG–24 brain new-plus: RMS – Recorder and Medicare systems. In this study, the folate-deficient animal model was used to mimic human methanol metabolism in rats. After 90 days of aspartame treatment, a significant alteration was observable in the time domain [Mean RR (ms SDNN (ms RMSSD (ms PNN50 (%] and the frequency domain [LF, HF, and LF/HF ratio] with significantly impaired frequency and amplitude of the fronto-parietal and occipital EEG waves at p ≤ 0.05. The results of this study clearly indicate that the oral consumption of aspartame reduced HRV, with sympathetic dominance and loss of vagal tone, and altered sympathovagal activity along with impairment of learning and memory, showing an additional effect on health within this study duration. The aspartame metabolites methanol and formaldehyde may be the causative factors

  4. Prevention of radiation and cadmium induced haematological alternations in the Swiss albino mice by Aloe Vera

    International Nuclear Information System (INIS)

    Agarwal, Manisha; Songara, Venkteshwar; Singariya, Seema; Meena, Dinesh; Chakrawarti, Aruna; Purohit, R.K.

    2013-01-01

    The development of effective radio protectors and radio recovery drugs is of great importance in view of their potential application during both planned (i.e., radiotherapy) and unplanned radiation exposure (i.e., in the nuclear industry and natural background radiation). The combined effect of radiation and cadmium further increases the causation of damages to organs and tissues. Aloe vera has enjoyed a reputation as a healer for millennia, based primarily on anecdotal evidence. For the last 40 years concerted efforts by the scientific research community has brought Aloe vera out of the realm of folk medicine, providing it solid medical and scientific foundation. Haematopoietic organs are among the most radiosensitive cells in the living organisms. Therefore, present study was carried out to study the modulatory influence of Aloe vera against radiation and cadmium induced hematological changes in the Swiss albino mice. For the study, six to eight weeks old male Swiss albino mice were procured and kept in polypropylene cages.The animals were exposed 3.5 Gy and 7.0 Gy of gamma radiation with or without cadmium chloride treatment. The Aloe vera was administered seven days prior to irradiation or cadmium chloride treatment. Five animals from each group were autopsied by cervical dislocation at each post treatment interval of 1, 2, 4, 7, 14 and 28 days. Blood was collected in heparinized tubes to estimate various haematological parameters viz. RBC, WBC, PCV, Haemoglobin and MCV. Radiation exposure resulted in a significant decline in RBC, WBC, PCV, Haemoglobin and MCV up to day-14 in peripheral blood, thereafter it increased up to day-28 without reaching to normal. After combined treatment of radiation and cadmium chloride the more severe changes were noticed showing synergistic or additive effect. An early and fast recovery was seen in Aloe vera pretreatment groups. Thus, it may be concluded from above observation that Aloe vera has the potential of combating the

  5. Modification Of Cesium Toxicity By Prussian Blue In Adult Male Albino Rats

    International Nuclear Information System (INIS)

    MANGOOD, S.A.; HAGGAG, A.M.

    2009-01-01

    The purposes of this study were to asses the toxicological effects of stable cesium chloride, and investigate the possible therapeutic role of Prussian blue (PB) in adult male albino rats.Thirty two adult male albino rats were used in this study and classified to 4 groups (8 rats/group) as follows:1- Group one (G1): rats were considered as controls and kept on the commercial diet without any treatments.2-Group two (G2): treated with daily oral cesium chloride (50 mg/300 g body weight).3-Group three (G3): treated with daily oral Prussian blue (250 mg/rats).4-Group four (G4): treated with cesium chloride at a daily oral dose of 50 mg/300 g body weight + Prussian blue at a daily oral dose of 250 mg/rats.All animals were administered the CsCl and/or PB via intubation tube and the duration of this study was 35 consecutive days. Hemoglobin (Hb), hematocrit (Ht%), red blood cells (RBC), white blood cells (WBC), folic acid, vitamin B12, total protein, albumin, globulin, A/G ratio, ALT, AST, total bilirubin, alkaline phosphatase, blood glucose, urea, creatinine, creatine phosphokinase (CPK), lactate dehydrogenase (LDH), sodium, potassium, calcium and inorganic phosphorous and body weight were determined in all groups.The data obtained revealed that the intake of stable cesium chloride in adult male rats caused significant decreases in the Hb, hematocrit, folic acid, vitamin B12 and potassium contents, with significant increases in WBC count, urea and creatinine levels and no effect on the other parameters. On the other hand, PB as a therapeutic agent caused significant amelioration in the changes produced by CsCl with variable degrees leading to the conclusion that the therapeutic agents might provide a protection against the toxicological effects of CsCl.

  6. Linfangioma cervical: manejo terapéutico con OK-432 (Picibanil Cervical lymphangioma: therapeutic management with OK-432 (Picibanil

    Directory of Open Access Journals (Sweden)

    E. Valle Rodríguez

    2007-12-01

    Full Text Available Introducción: El linfangioma es una malformación del sistema linfático. El abordaje clásico ha sido la cirugía. El OK-432 (Picibanil tiene acción esclerosante y se está utilizando cómo primer escalón terapéutico. El objetivo es aportar un nuevo caso de linfangioma tratado con OK-432 y hacer una revisión de la literatura. Material y método: Aportamos un varón de 16 años con un linfangioma cervical macroquístico de 10 x 6 cm tratado con una dosis de OK-432. Resultados: A las 16 semanas del tratamiento, el tamaño del linfangioma era de 6 x 2 cm, siendo clínicamente inapreciable. Discusión: El tratamiento con OK-432 tiene una alta tasa de curación, con una baja tasa de recidiva y una fibrosis circunscrita a la lesión. En relación con la cirugía, se evitan cicatrices y posibles lesiones de estructuras vitales.Introduction: Lymphangioma is a malformation of the lymphatic system. The classic approach is surgery. OK-432 (Picibanil has sclerosing action and is being used as the first therapeutic step. The objective was to report a new case of lymphangioma treated with OK-432 and to review the literature. Material and method: We report the case of a 16-year-old man with a 10x6-cm macrocystic cervical lymphangioma treated with a dose of OK-432. Results: At 16 weeks of treatment, the size of the lymphangioma was 6x2 cm and it was clinically unappreciable. Discussion: OK-432 treatment has a high cure rate, low recurrence rate, and fibrosis circumscribed to the lesion. Compared to surgery, scars and possible harm to vital structures are avoided.

  7. Shelf life of peaches treated with 1-methylcyclopropene Vida útil de pêssegos tratados com 1-metilciclopropeno

    Directory of Open Access Journals (Sweden)

    Ricardo Alfredo Kluge

    2002-03-01

    Full Text Available Peaches [Prunus persica (L. Bastch] present reduced post-harvest shelf life, partially, due to their high respiratory rate and fast ripening. These processes are related to ethylene production, as well as its action. Peaches, cv. Aurora-1, were picked at two different ripening stages (mature green and ripe and treated with 1-methylcyclopropene (1-MCP, the ethylene's competitive antagonist, at concentrations of 0, 100, 300 and 900 nL L-1 for 12 hours at 25ºC. After treatment, the fruits were stored at room temperature (25ºC for six days. Fruits treated with 1-MCP presented better firmness and less ground color loss than non-treated fruits. The 1-MCP antagonist reduced the development of fruit rot at the mature green stage, but not at the ripe one. The 1-MCP shows commercial application potential in the treatment of peaches in order to delay the ripening process and increase their shelf life.Pêssegos [Prunus persica (L. Bastch] apresentam reduzida vida útil pós-colheita devido, em parte, a sua alta taxa respiratória e amadurecimento rápido. Estes processos estão relacionados com a produção e a ação do etileno. Pêssegos cv. Aurora-1 foram colhidos em dois estádios de maturação (verde e maduro e tratados com o antagonista competitivo do etileno 1-metilciclopropeno (1-MCP nas concentrações de 0, 100, 300 e 900 nL L-1, durante 12 horas a 25ºC. Após o tratamentos os frutos foram armazenados em condições ambientais (25ºC durante seis dias. Os frutos tratados com 1-MCP apresentaram maior firmeza de polpa e menor perda de coloração de fundo se comparado com os frutos não tratados. O 1-MCP reduziu o desenvolvimento de podridões em frutos do estádio verde, mas não em frutos maduros. O 1-MCP apresenta potencial de aplicação comercial em pêssegos, visando retardar o amadurecimento e aumentar sua vida útil de prateleira.

  8. LA PRACTICA CLÍNICA DEL TRABAJO SOCIAL CON LAS PERSONAS MAYORES. BEAVER MARIÓN L MILLER DONJNTERVENCIÓN PRIMARIA, SECUNDARIA, TERCIARIA. PAIDÓS, SEGUNDA EDICIÓN, ESPAÑA 1988,457 PÁGINAS.

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    Yesica Alexandra Rodríguez

    2012-08-01

    Full Text Available El texto brinda elementos clave para el desempeño del trabajo social con personas mayores. Los autores presentan una caracterización detallada de este tipo de población, dan a conocer formas practicas de intervención, tomando como referencia estudios de casos ya tratados y colocando al trabajador social en la posibilidad de observar aquellos papeles que pueda jugar en el momento de acceder esta población.

  9. La ciencia política en Colombia en el 2005-2006 : el análisis del conflicto armado y de las elecciones, dos temas tradicionales, pero con enfoques nuevos

    OpenAIRE

    Garibay , David

    2007-01-01

    Este reseña presenta un panorama de las trabajos académicos en ciencia politica publicados en Colombia en 2005 y 2006. Los temas del analisis del conflicto armado interno y del comportamiento electoral han dominado la produccion cientifica colombiana. Estos dos temas, sobre los cuales existe una tradicion establecida en Colombia, han sido tratados con enfoques nuevos, y de manera autonoma uno del otro

  10. Giochiamo con i robot

    Directory of Open Access Journals (Sweden)

    Andrea Bonarini

    2009-01-01

    Full Text Available "Giochiamo con i robot" e' un laboratorio interattivo per grandi e piccini realizzato per l'edizione 2007 del Festival della Scienza di Genova. Lungo un percorso che va dalla telerobotica alla robotica evolutiva, il laboratorio sviluppa il tema di dare intelligenza ai robot. Questo percorso, le cui tappe sono le varie installazioni, si conclude nella "bottega" dove e' possibile costruire e programmare i propri robot o smontare e modificare quelli esposti durante il percorso didattico. I visitatori sono coinvolti in attivita' ludiche grazie alle quali possonoentrare in contatto con alcune delle idee potenti della robotica,

  11. disegnare con ... Alberto Pratelli

    Directory of Open Access Journals (Sweden)

    Roberto Mingucci

    2017-12-01

    Full Text Available Con questa breve intervista ad Alberto Pratelli, (non a caso scelto per aprire questa nuova rubrica intendia-mo inaugurare un dialogo con personalità significati-ve del Disegno di Architettura, che consenta riflessioni dedicate alle sue varie dimensioni, oggi più che mai da approfondire. La suggestione a farlo, viene da un’idea di Pablo Rodri-guez Navarro ed abbiamo quindi pensato di avviarla proprio in questo numero, che Pablo ha accettato di curare su un tema a lui particolarmente caro.

  12. Tratamiento endovascular de una fuga paraprotésica mitral con dispositivo Amplatzer®

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    Alberto Sciegata

    2012-10-01

    Full Text Available El leak o fuga paraprotésica mitral se presenta entre el 5 y el 17% de los pacientes tratados con cirugía de reemplazo valvular. En general, los defectos son únicos, la mayoría se encuentran localizados en la región postero-medial del anillo valvular y solo la tercera parte produce reflujo de grado grave. El cierre percutáneo por vía endovascular es una alternativa terapéutica válida en pacientes con elevado riesgo para re-operación. La estrategia de abordaje depende de la localización, tamaño, morfología y relaciones adyacentes del o los defectos. El procedimiento debe ser realizado por profesionales con experiencia en el tratamiento de cardiopatías estructurales y en el manejo de estos dispositivos de cierre, y se considera imprescindible la utilización de un ecocardiograma transesofágico tridimensional. Se presenta el caso de un paciente con una fuga paraprotésica valvular mitral que fue cerrada con un dispositivo Amplatzer ® introducido en forma percutánea desde la vena femoral.

  13. Tiempo de excreción de Vibrio cholerae O1 en pacientes con tratamiento

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    Elizabeth Castañeda

    1992-12-01

    Full Text Available El tiempo de excreción del Vibrio cholerae O1 en pacientes con cólera está influenciado por el tratamiento antimicrobiano. Se determinó en un grupo de pacientes con diagnóstico bacteriológico de cólera, que empezaron a recibir tratamiento con antibióticos una vez establecido el diagnóstico clínico, el tiempo de excreción del V. cholerae O1 empleando muestras de materia fecal obtenidas dentro de los cinco días siguientes al diagnóstico clínico inicial. En las 32 muestras obtenidas en ese período de cinco días el porcentaje de negativos fue del 81,2% (26/ 32; en 21 muestras obtenidas 24 horas después de haberse establecido el diagnóstico, se observó negativización en el 81% (17/21. Con nuestros datos podemos confirmar, al compararlos con los datos de la literatura en pacientes no tratados, que el tratamiento acorta el periodo de excreción del V. cholerae O1.

  14. Valvuloplastia mitral percutánea de emergencia en un paciente con edema pulmonar refractario

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    Alejandra I. de Zubiría

    2018-01-01

    Full Text Available La estenosis mitral usualmente es causada por fiebre reumática. A pesar de ser una patología poco frecuente en los países desarrollados, es prevalente en los países en vía de desarrollo, donde aproximadamente dos tercios de la población mundial vive, haciendo de esta condición, una enfermedad valvular común. Es importante considerar la estenosis mitral en el diagnóstico diferencial de los pacientes con edema agudo de pulmón cardiogénico refractario y la valvuloplastia mitral percutánea de emergencia como el tratamiento definitivo. Se presenta el caso de un paciente femenino de 21 años, con edema agudo de pulmón cardiogénico refractario, secundario a estenosis mitral muy severa de origen reumático, tratado con valvuloplastia percutánea con balón de urgencia. Se realiza una revisión sobre la estenosis mitral y se examina el tratamiento con especial énfasis en los casos publicados en la literatura de valvuloplastia mitral percutánea de emergencia.

  15. Retención y Penetración en Estacones de Eucalyptus Saligna. Sometidos a Tratamiento con CuSO4 y Sal CCC, en Baño Caliente y frio y Vacio-Presión

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    Escobar C. Oscar

    1987-09-01

    Full Text Available Este trabajo describe y da los resultados obtenidos con el pretratamiento de estacones de Eucalyptus saligna a tres soluciones de CUS04 y su posterior tratamiento con sales CCA (OSMOSE K-33. El sulfato de cobre se aplicó por el método de baño caliente y frío, seguido por el proceso de difusión durante una semana; para los anteriores tratamientos se usó madera verde o parcialmente seca al aire; las sales CCA se aplicaron a madera seca por el método de vacío-presión. Una de las razones para llevar a cabo este refuerzo de las sales CCA, es haber encontrado postes de eucalipto severamente atacados por hongos, en especial con pudrición blanda. Los estacones fueron tratados inicialmente con soluciones de sulfato de cobre a 1 %, 2% y 3% de concentración; luego los estacones fueron tratados con una solución de sal CCA al 2.5% de concentración por vacío-presión. Se usaron 40 estacones distribuídos en 4 grupos de 10: tres (3 grupos fueron usados para el tratamiento con las soluciones de CUS04 y solución de CCA; el grupo restante fue tratado con la sal CCA únicamente, el cual fue usado como grupo testigo para fines de comparación en los ensayos de campo (cementerios.

  16. O-PRECISION: UNA ALTERNATIVA METODOLÓGICA DE TRABAJO CON PERSONAS CON DISCAPACIDAD FÍSICA E INTELECTUAL

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    Victoria Rey Niño

    2015-04-01

    Full Text Available La Clasificación Internacional del Funcionamiento, de la Discapacidad y de la Salud (CIF define la discapacidad como un término genérico que abarca deficiencias, limitaciones de la actividad y restricciones a la participación. En este caso hablamos de personas con discapacidad física e intelectual por parálisis cerebral, lo que significa que su acceso al mundo de la actividad física se encuentra en la mayoría de los casos muy restringido. Pero existe una modalidad de la orientación llamada Orientación de Precisión u O-Trail que, según la Federación Deportiva de Orientación (FEDO, ha sido adaptada para ofrecer a todos, independientemente de su sexo, edad, capacidad o discapacidad física, la oportunidad de participar en igualdad de condiciones en una típica competición de orientación. Como sugiere Arribas y Sánchez (1998: “En la actividad física podemos encontrar recursos y herramientas de intervención adecuadas a cada contexto y etapa de ciclo vital además, a través de su práctica pueden verse satisfechas determinadas necesidades e intereses personales y grupales, que pueden ser tratados desde un planteamiento educativo” . Este proyecto tiene la intención de ir más allá y pretende utilizar la Orientación de precisión como una herramienta para implementar una alternativa metodológica de trabajo a las actividades que se llevan a cabo con un colectivo de personas con discapacidad física e intelectual en la Asociación Cultural y rehabilitadora de Discapacitados Físicos de Palencia, desarrollando y estimulando sus aspectos intelectuales y sociales mediante una disciplina deportiva desconocida para ellos, con la intención de que aumente su motivación por participar.Objetivo: Implementar la O-Precisión como alternativa metodológica de trabajo con personas con discapacidad física e intelectual con el fin de desarrollar sus capacidades cognitivas y aumentar su autoestima.

  17. El Tratado Antártico, vehículo de paz en un campo minado

    OpenAIRE

    Prieto Larrain, M. Cristina

    2004-01-01

    El 99% de la superficie de la Antártica, esto es 14 millones de Km², está cubierta por hielos de unos 2 Km de profundidad. Además de ser el continente más frío, la Antártica es también el más seco, ventoso y alto del mundo, con una elevación media de 2.500 Mt. Tales características físicas explican la ausencia de población humana indígena en el área, así como lo tardío de su exploración y explotación por parte de estados europeos y americanos entre otros. Sólo a partir del siglo XVIII comienz...

  18. Comparação das reservas glicogênicas em ratos jovens e envelhecidos tratados com picolinato de cromo

    OpenAIRE

    Rodrigues,Marcella Damas; Borin,Sérgio Henrique; Paulino,Patrícia Carla; Arruda,Eder João; Silva,Carlos Alberto da

    2014-01-01

    INTRODUÇÃO: Entre os suplementos utilizados no meio esportivo, o mineral cromo tem se destacado, principalmente por potencializar a ação da via insulínica, ação extremamente importante na manutenção da homeostasia metabólica. A ação do cromo parece ter ação importante como coadjuvante nas dinâmicas da ação insulínica. OBJETIVO: Avaliar o perfil glicogênico, bem como a sensibilidade tecidual à insulina e a pancreática à glicose em ratos jovens e envelhecidos tratados com picolinato de cro...

  19. Comparação das reservas glicogênicas em ratos jovens e envelhecidos tratados com picolinato de cromo

    OpenAIRE

    Rodrigues, Marcella Damas; Borin, Sérgio Henrique; Paulino, Patrícia Carla; Arruda, Eder João; Silva, Carlos Alberto da

    2014-01-01

    INTRODUÇÃO: Entre os suplementos utilizados no meio esportivo, o mineral cromo tem se destacado, principalmente por potencializar a ação da via insulínica, ação extremamente importante na manutenção da homeostasia metabólica. A ação do cromo parece ter ação importante como coadjuvante nas dinâmicas da ação insulínica.OBJETIVO: Avaliar o perfil glicogênico, bem como a sensibilidade tecidual à insulina e a pancreática à glicose em ratos jovens e envelhecidos tratados com picolinato de cromo.MÉT...

  20. Avaliação da dor pós-operatória em dentes tratados endodonticamente

    OpenAIRE

    Ademar Luiz Waskievicz; Flávia Baldissarelli; José Roberto Vanni; Mateus Silveira Martins Hartmann; Volmir João Fornari

    2015-01-01

    O sucesso do tratamento endodôntico está diretamente relacionado ao domínio da anatomia e ao controle da infecção endodôntica. Alguns fatores, como erros de procedimento (sobre instrumentação, obturação, desvios apicais e perfurações) podem causar dor pós-operatória. Objetivo: Este trabalho teve como objetivo avaliar a dor pós-operatória em dentes que foram tratados endodonticamente na Unidade de Pós-Graduação em Odontologia da Faculdade Meridional – IMED CEOM, de Passo Fundo, no período de j...

  1. Impacto del Tratamiento con Teriparatida en la Calidad de Vida de las Personas con Osteoporosis

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    Marta Osca Guadalajara

    2015-01-01

    Full Text Available La pérdida ósea en pacientes osteoporóticos, conlleva riesgo de fracturas, dolor óseo vertebral y disminución de la calidad de vida. El objetivo de este trabajo fue analizar el efecto de la teriparatida (TPTD en pacientes osteoporóticos y con dolor vertebral. Métodos: Estudio observacional longitudinal prospectivo, entre abril de 2006 y febrero de 2014, en los 77 pacientes tratados con TPTD en la Unidad del Dolor del Hospital de Teruel. La duración del tratamiento fue de 18 o 24 meses. Se utilizó la Escala Visual Analógica (EVA para la medición del dolor y el cuestionario europeo de calidad de vida (EuroQol-5D para obtener la tarifa social (TS, antes y después el tratamiento. Se realizó un análisis descriptivo, de regresión lineal y logística. Resultados: Se observó una mejoría del dolor (80% y de la calidad de vida (65 %. Se mejoró la EVA media (5,42 a 3,47 puntos y el EuroQol-5D (0,36 a 0,58 puntos. La regresión indicó una mejora de la EVA en 0,441 puntos por cada punto de EVA inicial, y de la TS en 0,0528 puntos por cada 0,1 puntos de TS inicial. La probabilidad de mejorar la EVA en 3 puntos (OR=2,021, fue mayor que de mejorar 2 puntos (OR=1,695. Conclusiones: La TPTD en pacientes osteoporóticos reduce el dolor óseo y mejora la calidad de vida. Su efecto es mayor en pacientes con peor estado de salud inicial, pudiendo ser utilizado como criterio para las decisiones terapéuticas y de gestión clínica.

  2. Tratamiento con inmunoterapia específica en niños con Rinitis Alérgica y/o Asma Bronquial. Área Norte. 2005 - 2007.

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    Matilde Iraida Morera Franco

    2007-10-01

    Full Text Available Se realizó un estudio descriptivo longitudinal durante el período Enero 2005_ Enero 2007 en el Policlínico Norte del municipio Sancti Spíritus. El universo estuvo constituido por el total de niños con edades de 2_15 años con enfermedades alérgicas, a los que se realizó pruebas de alergia e indicó tratamiento con inmunoterapia específica por vía subcutánea, la muestra estuvo formada por 75 pacientes con asma bronquial, rinitis alérgica y/o ambas enfermedades, con el objetivo de determinar el comportamiento del tratamiento con inmunoterapia específica se aplicó el método porcentual para el análisis de resultados, donde el grupo etáreo que predominó fue de 2 _5 años, más del 65 % de los pacientes tratados refirieron mejoría de los síntomas las causas más frecuentes de abandono de tratamiento fue la aparición de infecciones intercurrentes, no ocurrió reacción anafiláctica en ninguno de los casos estudiados, el tratamiento con inmunoterapia puede reducir el uso de otros tratamientos asociados como Intal, antihistamínicos, broncodilatadores y esteroides.

  3. Conversando con Oriol Bohigas

    OpenAIRE

    Redondo Domínguez, Ernesto; Moya Sala, Joaquim

    2015-01-01

    [EN] Interview with Oriol Bohigas [ES] Entrevista con Oriol Bohigas Redondo Domínguez, E.; Moya Sala, J. (2015). Conversando con… Oriol Bohigas. EGA. Revista de Expresión Gráfica Arquitectónica. 20(26):22-35. doi:10.4995/ega.2015.4061 22 35 20 26

  4. DR Con o:

    African Journals Online (AJOL)

    which could fall under the Ugandan influence. The con-. flict in the ..... The Congolese people and international community within SADC, the AU ..... ments and make peace among themselves. However, one ... friends overnight.There is a great ...

  5. Note on breeding and parental care behaviours of albino Hoary-bellied Squirrel Callosciurus pygerythrus (Rodentia: Sciuridae in Sibsagar District of Assam, India

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    G. Kalita

    2009-06-01

    Full Text Available A few individuals of albino Horay-bellied Squirrels along with normal gray individuals of Callosciurus pygerythrus have been observed in Sibsagar district of Assam, India. One albino female was studied in captivity. This paper presents our observations on the breeding behaviour and the parental care exhibited by the albino squirrel in captivity. The squirrel bred twice in captivity with a normal male of the same species. In both the periods, a single male baby with normal coat colour developed. Oral dose of vitamin E has been found helpful in the breeding of the studied squirrel species. The mother squirrel exhibited parental care by carrying her baby using her mouth, to a safer place during danger. However, the observed phenomenon is unlike that of the cat species. Some of the habitat ecology and feeding habits of the albino squirrels have also been studied, both in natural and in captive conditions.

  6. fertilizada con diferentes abonos

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    Jorge Alberto Elizondo-Salazar

    2007-01-01

    Full Text Available Producción y calidad de la biomasa de morera (Morus alba fertilizada con diferentes abonos. Se llevó a cabo un experimento en la Estación Experimental “Alfredo Volio Mata” de la Universidad de Costa Rica con el fi n de evaluar la aplicación de 150 kg de N/ha/año proveniente de dos abonos orgánicos: lombriabono y compostaje; y de un fertilizante químico, sobre la producción y calidad de la biomasa de morera. El periodo experimental comprendió un ciclo de 12 meses, iniciando en julio del 2003 y fi nalizando en julio del 2004. Se utilizó una plantación de morera de 12 años de establecida con una densidad de siembra de 27.777 plantas/ ha. Se empleó un diseño de bloques completos al azar con cuatro tratamientos: dos abonos orgánicos, nitrato de amonio (33,5% N y un control. Las plantas se podaron a 0,6 m sobre el nivel del suelo al inicio del ensayo. Durante el periodo experimental, las plantas fueron podadas consecutivamente cada 90 días. Las hojas y los tallos fueron separados y analizados para determinar el contenido de materia seca y proteína cruda. La producción de materia seca fue 23% superior y el contenido de proteína cruda fue signifi cativamente mayor con el nitrógeno químico, mientras que el contenido de materia seca fue menor. No se encontraron diferencias signifi cativas entre el tratamiento control y los tratamientos orgánicos.

  7. Estabilidad de emulsiones preparadas con proteínas de sueros de soja

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    Jorge Wagner

    2011-12-01

    Full Text Available Por precipitación con acetona en frio, se obtuvieron muestras de proteínas aisladas de dos sueros de soja, el suero SS proveniente de la obtención de aislados de soja y el suero de tofu ST. A partir del SS y del mismo suero previamente liofilizado y calentado (SSLC se obtuvieron las proteínas denominadas PSS y PSSLC, respectivamente; a partir de ST se preparó la muestra PST. El objetivo del trabajo fue analizar la estabilidad de emulsiones o/w preparadas con las proteínas de sueros de soja en forma comparativa con un aislado de soja nativo (ASN. Las emulsiones se prepararon por homogeneización de dispersiones proteicas (0,1–1,0 % p/v en buffer fosfato 10 mM pH 7 y aceite de girasol (Φmásico=0,33, empleando un Ultraturrax T-25. La estabilidad fue evaluada por medida del aceite separado, distribución de tamaño de partículas (por difracción láser y los grados de cremado y coalescencia evaluados a través de perfiles de BackScattering. Se observó que en todas las concentraciones ensayadas las emulsiones preparadas con proteínas aisladas (por precipitación con acetona en frío de suero de tofu tratado térmicamente (PST tenían una estabilidad comparable a la de emulsiones preparadas con ASN. Se halló una estabilidad menor en emulsiones con proteínas nativas de suero de soja (PSS obtenido en laboratorio no tratado térmicamente. Las proteínas obtenidas de este suero liofilizado y calentado (PSSLC exhibieron una mejor capacidad emulsionante. Los resultados mostraron que las proteínas de sueros de soja presentan buenas propiedades emulsionantes y estabilizantes dependientes del grado de desnaturalización y glicosilación alcanzado.

  8. MODELADO DE LA CINÉTICA DE SECADO DE MANGO PRE-TRATADAS CON DESHIDRATACIÓN OSMÓTICA Y MICROONDAS

    Directory of Open Access Journals (Sweden)

    MARIBEL GARCÍA-PATERNINA

    Full Text Available La aplicación de tecnologías complementarias como la deshidratación osmótica y microondas como pre-tratamientos al secado convencional contribuye al desarrollo de nuevos productos y favorece la disminución de los cambios físico-químicos y organolépticos en el mango. El objetivo del trabajo fue evaluar el efecto de la deshidratación osmótica con una solución a 65°Brix de 37 a 40°C por 60 min, tratamiento con microondas a 560 W por 7 min y combinado como pre-tratamientos al secado de hojuelas de mango a 70°C en una estufa tipo bandeja y al sol. Las muestras de mango con 11 a 14°Brix y humedad del 80% fueron dimensionadas a 1x1x0,4 cm. La pérdida de peso y el tiempo de secado en los pre-tratados presentaron diferencias significativas (p0,99 se ajustó para el secado sin pre-tratamiento y el modelo de Vermet et al. (R²>0,99 para los pre-tratados. La De ff para microondas y secado en estufa fue mayor. Las hojuelas de mango pre-tratadas con deshidratación osmótica fueron las que mejor conservaron la apariencia de las hojuelas de mango

  9. Antigenotoxic potential of Asparagus racemosus root extract against electron beam radiation induced micronuclei formation in Swiss albino mice

    International Nuclear Information System (INIS)

    Bhandary, B. Satheesh Kumar; Sharmila, K.P.; Suchetha Kumari, N.; Bhat, Vadish S.; Shetty, Jayaram; Peter, Alex John; Jose, Jerish M.; Fernandes, Ronald

    2016-01-01

    To evaluate the antigenotoxic potential of Asparagus Racemosus Root ethanolic extract (ARE) against electron beam radiation induced micronuclei formation in Swiss albino mice. Micronucleus assay was performed in the bone marrow of Swiss albino mice according to the method of Hosseinimehr et al., 2003. The experimental animals were orally administered 200 mg/kg body weight of ARE once daily for 15 consecutive days. At the end of experimental period, the animals were euthanized and the bone marrow was collected from the femur. Control (C), Radiation control (RC) and drug control (DC) group was also maintained. The number of radiation induced Micronucleated Polychromatic Erythrocytes (MnPCE) and Micronucleated Normochromatic Erythrocytes were decreased in the ARE treated mice which was statistically significant (p<0.05) compared to radiation control group. Present findings demonstrate the antigenotoxic potential of ARE against electron beam radiation induced micronuclei formation which may be attributed to scavenging of radiation-induced free radicals

  10. Protective effect of Asparagus racemosus root extract against lethal total - body electron beam radiation induced damage in Swiss albino mice

    International Nuclear Information System (INIS)

    Sharmila, K.P.; Bhandary, B. Satheesh Kumar; Suchetha Kumari, N.; Bhat, Vadish S.; Shetty, Jayaram; Peter, Alex John; Jose, Jerish M.; Fernandes, Ronald

    2016-01-01

    To investigate the protective effect of Asparagus Racemosus Root ethanolic extract (ARE) in Swiss albino mice against acute lethal total - body Electron beam irradiation. Swiss Albino mice were used for the assessment of radiation induced sickness and 30 day survival analysis. Survival studies were determined using the Kaplan-Meier survival curves. The maximum survival was observed in the experimental mice pretreated with 200 mg/kg.b.wt. of ARE which also reduced the radiation sickness characteristics. This dose was considered as an optimal dose for radioprotection. Treatment of mice with ARE before irradiation delayed the onset of mortality as compared with the untreated irradiated controls. Present findings demonstrate the potential of ARE in mitigating radiation-induced mortality, which may be attributed to its free radical scavenging and increased antioxidant potential

  11. Hematoma após raquianestesia tratado conservadoramente: relato de caso e revisão da literatura Hematoma después de raquianestesia tratado conservadoramente: relato de caso y revisión de la literatura Conservative treatment of hematoma after spinal anesthesia: case report and literature review

    Directory of Open Access Journals (Sweden)

    Daniel Segabinazzi

    2007-04-01

    objetivo de este trabajo fue describir un caso de hematoma después raquianestesia tratado de forma conservadora y revisar los trabajos en la literatura. RELATO DEL CASO: Paciente del sexo masculino, 73 años, 65 kg, 1,67 m, estado físico ASA III. Fue sometido a raquianestesia para retirada de catéter de diálisis peritoneal. Durante la realización de la punción hubo parestesias en el miembro inferior derecho. Se inyectaron 15 mg de bupivacaína hiperbárica a 0,5% sin vasoconstrictor. Veinte y cuatro horas después de la realización del bloqueo el paciente permanecía con anestesia en silla de montar y con dolor lumbar, y 48 horas después del procedimiento presentó una incontinencia urinaria. La resonancia nuclear magnética demostró la existencia de un proceso expansivo subaracnoideo, con compresión de raíces nerviosas (L4 a S1. Después de la evaluación del neurocirujano, se empieza el tratamiento conservador. El paciente recibió alta hospitalaria el 18° día de postoperatorio asintomático. CONCLUSIÓN: El caso presentado mostró una buena evolución con el tratamiento conservador.BACKGROUND AND OBJECTIVES: Spinal anesthesia caries the risk of bleeding. Compression of nervous tissue secondary to the formation of a hematoma can cause neurological damage, which, if not diagnosed and treated in a timely fashion, can be permanent. The identification of risk factors, diagnosis, and early treatment are important for the prognosis. The objective of this report was to describe the case of a hematoma after spinal anesthesia treated conservatively, and review the literature. CASE REPORT: Male patient, 73 years old, 65 kg, 1.67 m, and ASA physical status III, underwent spinal anesthesia for removal of a peritoneal dialysis catheter. During the puncture, the patient experienced paresthesia of the right lower limb. Fifteen milligrams of 0.5% hyperbaric bupivacaine without vasoconstrictor were administered. Twenty-four hours later, saddle anesthesia and lumbar pain

  12. Ameliorative Effects of Acacia Honey against Sodium Arsenite-Induced Oxidative Stress in Some Viscera of Male Wistar Albino Rats

    OpenAIRE

    Muhammad Aliyu; Sani Ibrahim; Hajiya M. Inuwa; Abdullahi B. Sallau; Olagunju Abbas; Idowu A. Aimola; Nathan Habila; Ndidi S. Uche

    2013-01-01

    Cancer is a leading cause of death worldwide and its development is frequently associated with oxidative stress-induced by carcinogens such as arsenicals. Most foods are basically health-promoting or disease-preventing and a typical example of such type is honey. This study was undertaken to investigate the ameliorative effects of Acacia honey on sodium arsenite-induced oxidative stress in the heart, lung and kidney tissues of male Wistar rats. Male Wistar albino rats divided into four groups...

  13. Role of the brain dopaminergic and opioid system in the regulation of "child's" (maternal bonding) behavior of newborn albino rats.

    Science.gov (United States)

    Stovolosov, I S; Dubynin, V A; Kamensky, A A

    2011-01-01

    Administration of D(2) receptor antagonist clebopride in a dose not affecting locomotor activity was followed by a decrease in maternal bonding behavior of 10-day-old and 15-day-old albino rat pups. D(1) receptor antagonist SCH23390 had a stimulatory effect only on the behavior of 10-day-old newborns. Opioid peptide β-casomorphin-7 abolished the effect of clebopride in rat pups of the older age group.

  14. Effects of Calendula Essential Oil-Based Cream on Biochemical Parameters of Skin of Albino Rats against Ultraviolet B Radiation

    OpenAIRE

    MISHRA, Arun; MISHRA, Amrita; VERMA, Anurag; CHATTOPADHYAY, Pronobesh

    2012-01-01

    Reactive oxygen species (ROS) generated from UV-B radiation have the capacity to cause oxidative decomposition which leads to the formation of toxic components as well as lipid peroxidation. Considering this fact, the present study was performed to evaluate the effect of a cream (O/W) containing the essential oil of Calendula officinalis on biochemical parameters of the skin of albino rats against UV-B radiation. The fingerprint analysis of Calendula essential oil was performed by HPLC with s...

  15. Estudo quantitativo do nervo frênico de rato albino em função do envelhecimento

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    Romeu Rodrigues de Souza

    1990-01-01

    Full Text Available The phrenic nerve of albino rats was studied for age changes in number of fibres, myelin sheath thickness and axon calibre. Nerves were excised from three young and three aged rats. There is no significant morphological differences between nerves from young and aged rats and no difference with age was found in the number of fibres, myelin sheath thickness and axon calibre.

  16. [Histochemical detection of glycoproteins and glycosaminoglycans in the respiratory mucosa of albino rats during estrous cycle, pregnancy and puerperium].

    Science.gov (United States)

    Pontes, P A; Simões, M J; Merzel, J

    1989-11-01

    In this work we attempted to detect, with histochemical methods, the possible modifications in the mucus of the respiratory mucosa of albino female rats during estral cycle, pregnancy and puerperium. Based on its results, it was possible to conclude that: a--There were no modifications in the nature of the epithelial and supraepithelial mucus during the studied periods: b--The Alcian Blue staining from lamina propria is absent during pregnancy and present during puerperium.

  17. Protective effects of fennel oil extract against sodium valproate-induced hepatorenal damage in albino rats

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    Wael M. Al-Amoudi

    2017-05-01

    Full Text Available Foeniculum vulgare (Apiaceae is commonly known as fennel. This herb is well-known worldwide and traditionally used as curative herbal therapy for the treatment of epileptic disease, seizurescarminative, digestive, lactogogue, diuretic, treating respiratory and gastrointestinal disorders. The aim of present study is to investigate the possible effect of fennel oil against the toxicity of Sodium-Valproic (SVP in albino rats. In order to assess the protection of fennel oil on SVP induced hepato- and nephro-toxicity, male albino rats were treated with 1 ml/kg b.w fennel oil 3 days/week for 6 weeks. The biochemical analyses of hepatic enzymes were evaluated by estimating blood biomarkers of liver and renal damage along with histological examination. The results obtained from this work showed that treating animals with SVP lead to many histopathological alterations in the liver and kidney tissues. The effect appeared in the liver tissue include leukocyte infiltrations, cytoplasmic vacuolization of the hepatocytes, fatty degeneration and congestion of blood vessels. This commonly used chemical (SVP caused some unwanted effects on the kidney cortex which histologically observed as degeneration in renal tubules, atrophy of the glomeruli and edema. Biochemical results also revealed an abnormal increase in the enzyme level of AST, SAT, ALP, bilirubin, creatinine and urea-nitrogen, with a noticed decrease in total protein content. However, the results of treated rats with SVP plus fennel oil showed some positive histopathological changes in both the liver and kidney tissues. These results have confirmed that fennel oil has positive effects on the histological structure of the liver and kidney and the biochemical levels of AST, ALT, ALP, bilirubin, total proteins, creatinine and urea. It is concluded that fennel oil has various pharmacological properties including antioxidant, anti-cancer activity, anti-inflammatory. These valuable effects might be due to

  18. Proteomic analysis of young leaves at three developmental stages in an albino tea cultivar

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    Li Juan

    2011-08-01

    Full Text Available Abstract Background White leaf No.1 is a typical albino tea cultivar grown in China and it has received increased attention in recent years due to the fact that white leaves containing a high level of amino acids, which are very important components affecting the quality of tea drink. According to the color of its leaves, the development of this tea cultivar is divided into three stages: the pre-albinistic stage, the albinistic stage and the regreening stage. To understand the intricate mechanism of periodic albinism, a comparative proteomic approach based on two-dimensional electrophoresis (2-DE and mass spectrometry was adopted first time to identify proteins that changed in abundance during the three developmental periods. Results The 2-DE results showed that the expression level of 61 protein spots varied markedly during the three developmental stages. To analyze the functions of the significantly differentially expressed protein spots, 30 spots were excised from gels and analyzed by matrix-assisted laser desorption ionization-time of flight-tandem mass spectrometry. Of these, 26 spots were successfully identified. All identified protein spots were involved in metabolism of carbon, nitrogen and sulfur, photosynthesis, protein processing, stress defense and RNA processing, indicating these physiological processes may play crucial roles in the periodic albinism. Quantitative real-time RT-PCR analysis was used to assess the transcriptional level of differentially expressed proteins. In addition, the ultrastructural studies revealed that the etioplast-chloroplast transition in the leaf cell of White leaf No. 1 was inhibited and the grana in the chloroplast was destroyed at the albinistic stage. Conclusions In this work, the proteomic analysis revealed that some proteins may have important roles in the molecular events involved in periodic albinism of White leaf No. 1 and identificated many attractive candidates for further investigation. In

  19. Visualisation of cerebrospinal fluid flow patterns in albino Xenopus larvae in vivo

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    Mogi Kazue

    2012-04-01

    Full Text Available Abstract Background It has long been known that cerebrospinal fluid (CSF, its composition and flow, play an important part in normal brain development, and ependymal cell ciliary beating as a possible driver of CSF flow has previously been studied in mammalian fetuses in vitro. Lower vertebrate animals are potential models for analysis of CSF flow during development because they are oviparous. Albino Xenopus laevis larvae are nearly transparent and have a straight, translucent brain that facilitates the observation of fluid flow within the ventricles. The aim of these experiments was to study CSF flow and circulation in vivo in the developing brain of living embryos, larvae and tadpoles of Xenopus laevis using a microinjection technique. Methods The development of Xenopus larval brain ventricles and the patterns of CSF flow were visualised after injection of quantum dot nanocrystals and polystyrene beads (3.1 or 5.8 μm in diameter into the fourth cerebral ventricle at embryonic/larval stages 30-53. Results The fluorescent nanocrystals showed the normal development of the cerebral ventricles from embryonic/larval stages 38 to 53. The polystyrene beads injected into stage 47-49 larvae revealed three CSF flow patterns, left-handed, right-handed and non-biased, in movement of the beads into the third ventricle from the cerebral aqueduct (aqueduct of Sylvius. In the lateral ventricles, anterior to the third ventricle, CSF flow moved anteriorly along the outer wall of the ventricle to the inner wall and then posteriorly, creating a semicircle. In the cerebral aqueduct, connecting the third and fourth cerebral ventricles, CSF flow moved rostrally in the dorsal region and caudally in the ventral region. Also in the fourth ventricle, clear dorso-ventral differences in fluid flow pattern were observed. Conclusions This is the first visualisation of the orchestrated CSF flow pattern in developing vertebrates using a live animal imaging approach. CSF flow

  20. Dermal toxicity of Colloidal Nanosilver in Albino Rabbit: A New Approach to Physicochemical Properties

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    Anoushe Raesian

    2017-09-01

    Full Text Available Objective(s: Silver nanoparticles have been widely used as new potent antimicrobial agents in cosmetic and hygienic products, as well as in new medical devices. Serious concerns have been expressed on the potential health risks of dermal applications of nanosilver containing consumer products (AgNPs, therefore regulatory health risk assessment has become necessary for the safe usage of AgNPs in biomedical products with special emphasis to their dermal toxicity potentials. We aimed in the present study to compare the dermal toxicity of three different AgNP containing disinfectantsin an albino rabbit model and tried to determine the role of size and other physicochemical properties on their possible dermal toxicity. Methods: After the characterization of all three samples by transmission electron microscopy (TEM, X-Ray Diffraction (XRD and Dynamic Light Scattering (DLS , corrosive and irritant potentials  of AgNPs in three different sizes of three colloidal AgNPs were scored by the OECD 404 guideline with necessary modifications and were applied under the specified concentrations via nanosilver skin patches on the shaved skin of young female albino rabbits. All skin reactions were recorded in 3 min as well as in 1, 4, 24, 48 and 72 hours from the application and compared with the control group and followed up for 14 days. Results: Although short-term observations didn’t show any significant changes in the weight of animals and macroscopic  variables, long-term histopathological abnormalities were seen in the skin of all test groups, which was not associated with the size and other physicochemical properties of AgNP samples. The toxicity manifestations were dry skin, scaling in doses lower than 100 ppm and erythema in higher doses up to 4000 ppm which was reversed. Conclusions: This finding creates a new issue in the possible dermal effects of all colloidal AgNPs, containing nano health products, which should be considered in future studies by

  1. Distribution and ultrastructure of pigment cells in the skins of normal and albino adult turbot, Scophthalmus Maximus

    Institute of Scientific and Technical Information of China (English)

    GUO Huarong; HUANG Bing; QI Fei; ZHANG Shicui

    2007-01-01

    The distribution and ultrastructure of pigment cells in skins of normal and albino adult turbots were examined with transmission electron microscopy (TEM). Three types of pigment cells of melanophore, iridophore and xanthophore have been recognized in adult turbot skins. The skin color depends mainly on the amount and distribution of melanophore and iridophore, as xanthophore is quite rare. No pigment cells can be found in the epidermis of the skins. In the pigmented ocular skin of the turbot, melanophore and iridophore are usually co-localized in the dermis. This is quite different from the distribution in larvae skin. In albino and white blind skins of adult turbots, however, only iridophore monolayer still exists, while the melanophore monolayer disappears. This cytological evidence explains why the albino adult turbot, unlike its larvae, could never resume its body color no matter what environmental and nutritional conditions were provided. Endocytosis is quite active in the cellular membrane of the iridophore. This might be related to the formation of reflective platelet and stability of the iridophore.

  2. Blastocysts production and collection in albino Syrian hamster using superovulation and intrauterine artificial insemination in non-breeding season

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    A. Amiri Divani

    2017-06-01

    Full Text Available In vivo blastocyst production and collection using superovulation and intrauterine insemination was established in albino Syrian hamsters. Twenty female albino hamsters were injected pregnant mare serum gonadotropin (PMSG, 25 IU in non-breeding season and 48 h or 56 h later, 25 IU of human chorionic gonadotropin (hCG were injected. Both groups were divided into two subgroups of natural mating and artificial insemination. The former group was mated with a fertile male (1 male for 2 fe-males after hCG injection and in the next morning, the hamsters with vaginal plug were regarded as pregnant. In the artificial insemination group, intrauterine artificial insemination of 1×108 sperms was done 12 h after hCG injection. Blastocysts were counted at 3.5 days after mating or insemination. However, 48 h and 56 h hCG and natural mating and 48 h hCG and artificial insemination were without blastocyst; however the method of 56 h hCG and artificial insemination produced of 15±5 (mean and standard deviation blastocysts in each albino hamster in the winter.

  3. pacientes con falla cardiaca

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    Diana Marcela Achury Saldaña

    2007-01-01

    Full Text Available Objetivo: determinar la adherencia al tratamiento de pacientes con falla cardiaca hospitalizados, al aplicar un plan educativo quefomenta el autocuidado.Método: estudio cuasiexperimental (entrevistas enfermera-paciente realizado entre diciembre de 2004 y mayo de 2006, con unamuestra de 50 pacientes seleccionados por conveniencia. Se diseñó un instrumento para evaluar los comportamientos de los pacientes,con base en algunos resultados de la adherencia y sus respectivos indicadores de la taxonomía NOC (Nursing out comes classification. Laadherencia al tratamiento fue medida en dos momentos: el primero durante la hospitalización, seguido de la aplicación del plan educativoantes del alta, que proporcionaba información en el manejo de su enfermedad desde una dimensión física, psicológica y social quepromueve el autocuidado; y el segundo un mes después del alta en su domicilio.Resultados: diferencias estadísticamente significativas (P=0,0001 que demuestran cómo mediante la capacitación al paciente enel manejo de su tratamiento farmacológico y no farmacológico, el establecimiento de una sana relación entre el profesional de enfermeríay el paciente, y la participación de la familia, se logra una total adherencia al tratamiento.Conclusiones: para lograr una adherencia total del paciente con falla cardiaca al tratamiento es necesario un proceso educativo y unseguimiento continuo y personalizado que motive permanentemente al paciente y se le reconozca el papel protagónico en su cuidado y manejo de la enfermedad.

  4. El collar de la paloma : tratado sobre el amor y los amantes

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    Paulina López Pita

    1999-01-01

    Full Text Available Se recoge en este trabajo la opinión que algunos estudiosos han dado sobre una de las mejores obras de la literatura árabe, calificada por don Emilio García Gómez de auténtica joya literaria. Su autor, el ilustre polígrafo cordobés, Ibn Hazm (994-1064, comenzó a escribirla en el año 1022 en unas duras condiciones, como él mismo reconoce, cuando se hallaba cautivo en dativa. Por entonces, el califato cordobés mostraba ya sus primeros síntomas de debilidad. Esta obra esta escrita en árabe purísimo y en rica prosa en la que se intercalan versos con un profundo sentimiento. En ella su autor nos narra aspectos del amor basados en su propia experiencia, y en lo que le contaron gentes de fiar, transmitiendo, en suma, como amaron las gentes de al-Andalus durante el gobierno de la dinastía omeya; por este motivo, algunos consideran, en parte, este libro como la autobiografía de su autor y de las gentes que le rodearon. Ibn Hazm compuso esta obra por encargo de un amigo y a través de ella le ofrece, por la amistad que les une, «ayuda» para alcanzar la verdad. En los sucesivos capítulos de que consta «El collar», el autor nos habla de los fundamentos del amor, entre los que destaca, la esencia del amor, las formas de enamoramiento,etc... de los accidentes del amor y de sus cualidades loables y vituperables; de las malaventuras que sobrevienen al amor, de la fealdad del pecado y de la castidad. No obstante, a pesar del plan previo establecido por el autor, estos temas se mezclan unos con otros, y de ello se excusa Ibn Hazm. «El collar de la paloma» ha tenido una gran divulgación, siendo traducido a las principales lenguas, y en él han querido encontrar, estudiosos de la literatura medieval ciertas similitudes.This report contains some opinión from several experts about one of the masterpieces of the arab literature, considered as an authentic jewel by Emilio García Gómez. Its author, the famous cordovan polygraph Ibn Hazm (994

  5. Experiencia de la terapia con lokomat en pacientes portadores de parálisis cerebral y síndromes atáxicos, instituto de rehabilitación infantil teletón concepción Chile

    Directory of Open Access Journals (Sweden)

    D. Lorena Llorente, DRA.

    2014-03-01

    En el Instituto de Rehabilitación Infantil Teletón Concepción el Lokomat existe desde 2008. Esto ha permitido recoger experiencias relacionadas con los cambios observados en el desempeño de la marcha de niños con distintos trastornos de la marcha de origen neurológico tratados con esta órtesis robótica. Se presentan resultados preliminares de tres líneas de investigación que se están desarrollando actualmente incluyendo niños con Parálisis Cerebral Hemipléjica, Parálisis Cerebral dipléjica y con Síndromes Atáxicos.

  6. Reproductive, cytological and biochemical toxicity of Yohimbe in male Swiss albino mice.

    Science.gov (United States)

    Al-Majed, Abdulhakeem A; Al-Yahya, Abdulaziz A; Al-Bekairi, A M; Al-Shabanah, Othman A; Qureshi, Shoeb

    2006-07-01

    To study the effect of Corynanthe Yohimbe (Yohimbe) on germ cells in Swiss albino mice. Adult male mice were orally (gavage) treated with different doses (188, 375 and 750 mg/[kg x day]) of aqueous suspension of Yohimbe for 90 days. The following parameters were evaluated: (i) reproductive organ weight, (ii) motility and count of sperm, (iii) study on rate of pregnancy and mean implants, (iv) spermatozoa morphology, (v) cytology of the testes chromosomes, and (vi) biochemical study on estimation of proteins, RNA, DNA, malondialdehyde, nonprotein sulfhydryl (NP-SH) and hormones. The treatment caused significant increase in the weight of seminal vesicles, motility and count of spermatozoa, pre- and post-implants. Male fertility was decreased. These results are confirmed by our data on spermatozoa abnormalities and chromosomal aberrations. The data on biochemical parameters showed increase of malondialdehyde and depletion of NP-SH, proteins, RNA and DNA in the testicular cells. Our results elucidated the role of free radical species in cytological and reproductive changes, possibly, under the influence of yohimbine (principal constituent of Yohimbe) on neurotransmitters, including norephinephrine. These data warrant careful use of Yohimbe.

  7. Evaluation of antinociceptive and antidiarrhoeal properties of Manilkara zapota leaves in Swiss albino mice.

    Science.gov (United States)

    Ganguly, Amlan; Al Mahmud, Zobaer; Kumar Saha, Sajal; Abdur Rahman, S M

    2016-08-01

    Context Manilkara zapota (L.). P. Royen. (Sapotaceae) has been used in folk medicine to treat pain, diarrhoea, inflammation, arthralgia, and other disorders. Objective Screening of Manilkara zapota leaves ethanol extract and its different solvent soluble fractions for possible antinociceptive and antidiarrhoeal activities in Swiss albino mice. Materials and methods The extract and various fractions (200 and 400 mg/kg body weight; p.o.) were tested for peripheral and central antinociceptive activity by acetic acid-induced writhing and radiant heat tail-flick method, respectively; castor oil-induced diarrhoeal model was used to evaluate antidiarrhoeal activity at both doses. All the samples were administered once in a day and the duration of study was approximately 5 h. Results Ethanol extract (400 mg/kg), petroleum ether fraction (400 mg/kg), and ethyl acetate fraction (400 mg/kg) showed significant peripheral antinociceptive activity having 59.89, 58.24, and 46.7% (p analgesic activity having 74.15 and 82.15% (p screening, ethanol extract (200 and 400 mg/kg) showed significant inhibition of defecation by 53.57 and 60.71%, respectively (p < 0.001) compared with that of loperamide (71.42%). Discussion and conclusion The findings of the studies demonstrated antinociceptive and antidiarrhoeal activities of M. zapota leaves which could be the therapeutic option against pain and diarrhoeal disease.

  8. Autoradiographic localization of tritiated dihydrotestosterone in the flank organ of the albino hamster

    International Nuclear Information System (INIS)

    Lucky, A.W.; Eisenfeld, A.J.; Visintin, I.

    1985-01-01

    In the hamster flank organ, the growth of hair and growth of sebaceous glands are androgen-dependent functions. Although dihydrotestosterone (DHT) is known to be a potent stimulator of flank organ growth, there is no information about localization of DHT receptor sites in this organ. The purpose of this study was to use steroid autoradiography to localize DHT receptors in the hamster flank organ. Because steroid hormones are functional when translocated to nuclear receptors, nuclear localization by autoradiography defines receptor sites. In order to be able to visualize autoradiographic grains from radiolabeled androgens around hair follicles, albino hamsters were studied to avoid confusion between the grains and pigment granules which are abundant in the more common Golden Syrian hamster. Mature male hamsters castrated 24 hours earlier were given tritium-labeled dihydrotestosterone ( [ 3 H]DHT). Using the technique of thaw-mount steroid autoradiography, 4-micron unfixed frozen sections were mounted in the dark onto emulsion-coated glass slides and allowed to develop for 4-6 months. [ 3 H]DHT was found to be concentrated over sebocyte nuclei. The label was present peripherally as well as in differentiating sebocytes. There was no nuclear localization of [ 3 H]DHT in animals pretreated with excessive quantities of unlabeled DHT. Steroid metabolites of [ 3 H] DHT were assessed by thin-layer chromatography in paired tissue samples. Most of the label remained with DHT. Uptake was inhibited in the flank organ of hamsters pretreated with unlabeled DHT

  9. Radiation induced cerebellum impairments in Swiss albino mice and its modulation by dietary Prunus domestica

    International Nuclear Information System (INIS)

    Sharma, Garima; Sisodia, Rashmi

    2012-01-01

    To study the biochemical, quantitative histopathological and behavioural changes after 5 Gy whole body irradiation and its modulation by supplementation of Prunus domestica extract (PDE) for 15 consecutive days on male Swiss albino. For this study healthy mice from an inbred colony were divided into five groups: (i) Control; (ii) PDE treated - mice in this group were orally supplemented with PDE (400 mg/kg body weight (bw)/day) once daily for 15 consecutive days; (iii) Irradiated-mice were whole body exposed to 5 Gy irradiated; (iv) PDE + irradiated-mice in this group were orally supplemented PDE for 15 days (once a day) prior to irradiation; and (v) irradiated+PDE -mice in this group were administered PDE orally for 15 days (once a day) consequently after irradiation. Marked radiation induced changes in the amount of cerebellar lipid peroxidation (LPO), glutathione (GSH), protein, superoxide dismutase (SOD), catalase and histopathological changes (molecular layer, granular layer and purkinje cell numbers) could be significantly ameliorated supplementation of PDE prior/post irradiation. Radiation induced deficits in learning and memory were also significantly ameliorated. PDE was found to have strong radical scavenging activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH) and also showed in vitro radioprotective activity. The result of present study showed that prior/post-supplementation of Prunus domestica has radioprotective potential as well as neuroprotective properties against the radiation. (author)

  10. Serum biochemical responses under oxidative stress of aspartame in wistar albino rats

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    Arbind Kumar Choudhary

    2014-02-01

    Full Text Available Objective: To study whether the oral administration of aspartame (40 mg/kg body weight for 15 d, 30 d and 90 d have any effect on marker enzymes, some selective liver and kidney function parameter, lipid peroxidation and antioxidant status in serum. To mimic human methanol metabolism, folate deficient animals were used. Method: Animal weight, complete hemogram, marker enzyme in serum, some selected serum profile reflect liver and kidney function, plasma corticosterone level, and in serum, lipid peroxidation, nitric oxide, enzymatic and non-enzymatic antioxidant level was measured . Result: After 15 d of aspartame administration animals showed a significant change in marker enzymes, and antioxidant level. However, after repeated long term administration (30 d and 90 d showed a significant change in some selected serum profile reflects liver and kidney function, along with marker enzymes, and antioxidant level. Conclusions: This study concludes that oral administration of aspartame (40 mg/kg body weight causes oxidative stress in Wistar albino rats by altering their oxidant/antioxidant balance.

  11. Hepatoprotective efficacy of Grewia asiatica fruit against oxidative stress in swiss albino mice

    International Nuclear Information System (INIS)

    Sharma, K. V.; Sisodia, R.

    2010-01-01

    The radioprotective effect of Grewia asiatica fruit which contains anthocyanin type cyanidin 3- glucoside, vitamin C, A, minerals, carotenes and dietary fibers etc was studied. Materials and Methods: For study Swiss albino mice were divided into five groups-1. Control (vehicle treated) 2. Grewia asiatica fruit treated (700 mg / Kg. b.wt / day for fifteen days), 3. Irradiated (5 Gy), 4. Grewia asiatica fruit + Irradiated and 5. Irradiated + Grewia asiatica fruit treated. Results: The irradiation of animals resulted in a significant depletion in the DNA and RNA level at all intervals studied viz 1-30 days in comparison to control group. Treatment of mice with Grewia asiatica fruit before and after irradiation caused a significant elevation in liver DNA and RNA level in comparison to irradiated mice. Photomicrograph of liver histology also showed that pre and post supplementation of Grewia asiatica fruit provides protection against radiation. Similarly counting of different type hepatocytes also showed that Grewia asiatica fruit protect the liver against radiation. Conclusion: Thus biochemical and histopathological results proves that Grewia asiatica fruit has the potential against radiation.

  12. Clastogenic Effects of Glyphosate in Bone Marrow Cells of Swiss Albino Mice

    International Nuclear Information System (INIS)

    Prasad, S.; Srivastava, S.; Singh, M.; Shukla, Y.

    2009-01-01

    Glyphosate (N-(phosphonomethyl) glycine, C 3 H 8 NO 5 P), a herbicide, used to control unwanted annual and perennial plants all over the world. Nevertheless, occupational and environmental exposure to pesticides can pose a threat to nontarget species including human beings. Therefore, in the present study, genotoxic effects of the herbicide glyphosate were analyzed by measuring chromosomal aberrations (CAs) and micronuclei (MN) in bone marrow cells of Swiss albino mice. A single dose of glyphosate was given intraperitoneally (i.p) to the animals at a concentration of 25 and 50 mg/kg b.wt. Animals of positive control group were injected i.p. benzo(a)pyrene (100 mg/kg b.wt., once only), whereas, animals of control (vehicle) group were injected i.p. dimethyl sulfoxide (0.2 mL). Animals from all the groups were sacrificed at sampling times of 24, 48, and 72 hours and their bone marrow was analyzed for cytogenetic and chromosomal damage. Glyphosate treatment significantly increases CAs and MN induction at both treatments and time compared with the vehicle control (P<.05). The cytotoxic effects of glyphosate were also evident, as observed by significant decrease in mitotic index (MI). The present results indicate that glyphosate is clastogenic and cytotoxic to mouse bone marrow.

  13. Biochemical Effects Of Aluminum On Some Selected Serum Enzymes Of Male Wistar Albino Rats

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    Ogueche

    2015-08-01

    Full Text Available Toxic metals are widely found in our environment and humans are exposed to them via water contaminated air food and soil. Aluminum AL belongs to this group of toxic metals. Its neurological effects are well documented but effects on acid and alkaline phosphatases are poorly studied and this the essence of this study. Toxicity of aluminum was investigated based on the elevation of acid and alkali phosphatases in serum of male Wistar albino rats after days 7 and 14 of aluminum 0.38 3.8 and 38mgkg body weight administration respectively. The results showed significant increase p0.05 in serum acid phosphatase in the test animals given 38kgkg after days 14 while serum alkali phosphatase increased significantly p 0.05 in the test animals given 3.8 and 38 mgkg after days 7 and 14 when compared to the control animals. However lower dose 0.38mgkg showed increase in both serum acid and alkali phosphatases respectively but were statistically non-significant p0.05 at 7 and 14 as compared to control animals.

  14. Antiplasmodial Effect of Anthocleista vogelii on Albino Mice Experimentally Infected with Plasmodium berghei berghei (NK 65

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    Lebari Barine Gboeloh

    2014-01-01

    Full Text Available The objective of the present study was to investigate the antiplasmodial effect of the ethanolic stem bark extract of Anthocleista vogelii at different doses in albino mice infected with Plasmodium berghei berghei (NK 65. Thirty-six mice were divided into six groups of six mice each. Five groups (B1–B3, D, and G were infected with Plasmodium berghei berghei parasitized red blood cells. Groups D, H, and G served as the controls. Six days after infection, mice in groups B1, B2, and B3 were treated orally with 100, 200, and 400 mg/kg body weight of Anthocleista vogelii, respectively, for six executive days. Group D was treated with 5 mg/kg body weight of chloroquine while Group G was given distilled water. Group H was not infected and was not treated. It served as the normal control. The extracts exhibited significant (P<0.05 dose-dependent chemosuppression of P. berghei. The extract exhibited average chemosuppressive effects of 48.5%, 78.5%, and 86.6% at dose levels of 100, 200, and 400 mg/kg body weight, respectively. Phytochemical screening of the plant extract revealed the presence of saponins, cardiac glycosides, flavonoids, terpenes, alkaloids, and steroid. The acute toxicity (LD50 of the plant was estimated to be 3162 mg/kg body weight. It showed that the stem bark of A. vogelii possesses antiplasmodial property.

  15. Effects of gamma radiation on hard dental tissues of albino rats: investigation by light microscopy.

    Science.gov (United States)

    El-Faramawy, Nabil; Ameen, Reham; El-Haddad, Khaled; El-Zainy, Medhat

    2013-08-01

    The present work aims at studying the effect of gamma radiation on the hard dental tissues. Eighty adult male albino rats with weights of about 250 g were used. The rats were irradiated at 0.2, 0.5, 1.0, 2.0, 4.0 and 6.0 Gy whole-body gamma doses. The effects on hard dental tissue samples were investigated after 48 h in histological and ground sections using light microscopy. Areas of acid phosphatase activity were detected using tartrate-resistant acid phosphatase (TRAP) stains. Observation of histological sections revealed disturbance in predentin thickness and odontoblastic layer as the irradiation dose increased. In cementum, widened cementocytes lacunae were occasionally detected even with low irradiated doses. On the other hand, relatively homogenous enamel was detected with darkened areas in enamel surface at doses over than 0.5 Gy. TRAP-positive cells were detected on the surface of the dentin of irradiated groups as well as cementum surface. Minimal detectable changes were observed in ground sections.

  16. Behavioral effects of microwave reinforcement schedules and variations in microwave intensity on albino rats

    Energy Technology Data Exchange (ETDEWEB)

    Vitulli, W.F.; Lambert, J.K.; Brown, S.W.; Quinn, J.M.

    1987-12-01

    The objective of this exploratory investigation was to determine the interactive effects of fixed-ratio scheduling of microwave reinforcement in tandem with changes in microwave intensity. Nine albino rats were conditioned to regulate their thermal environment with microwave radiation while living in a Skinner (operant conditioning) Box in which the ambient temperature was about 27.13 degrees F at the beginning of the session. Each rat obtained a 6-sec. exposure of microwave radiation on a fixed-ratio schedule of MW reinforcement, the values of which varied from FR-1 to FR-30. Intensities of MW radiation were 62.5 W, 125 W, 250 W, and 437.5 W. Sessions lasted for 8 to 9 hr. over an approximate 13-mo. period. The effects of the intensity of microwave reinforcement varied as a function of the ratio value of the schedule used. Continuous reinforcement (FR-1) produced the lowest over-all rates, whereas FR-15, and FR-25 produced the highest over-all rates. Relatively higher thermal-behavior rates occurred under 62.5 W than under any of the other MW intensities for FR-1, FR-15, and FR-25, whereas FR-10 and FR-30 ratios produced intermediate rates of thermal responding which were constant for all values of MW intensity. These data are explained in terms of interactive effects between the local satiation or deprivation properties of the MW intensity and the ratio requirements of the schedule of MW reinforcement.

  17. Effects of split fast neutron doses on the liver cells of albino Swiss mice

    International Nuclear Information System (INIS)

    Abdelmeguid, N.; Ramadan, A.A.; El-Khatib, A.M.

    1990-01-01

    The effect of neutron doses from a compact D-T neutron generator on the liver cells of adult male and female albino Swiss mice was investigated. Fast neutrons (14.5 MeV) were delivered to the whole body in a single dose or in two, four, six or eight equal doses separated by 3-day intervals. The lowest dose, 100 rem, was given over an exposure time of 6 hours and was then steadily raised to 912 rem over an exposure time of 48 hours. During exposure the neutron flux was controlled by the activation foil technique. The animals were killed for testing after each irradiation. Histological examination of the hepatocytes with a light microscope showed marked degenerative changes only after the longer irradiation periods (24, 36 and 48 h). Electron microscopy showed cytological (cytoplasmic and nuclear) changes in the hepatocytes after only 12 hours' irradiation. Densitometric scans of electron micrographs of control and 12 h-irradiated livers indicated that the control hepatocyte interphase nucleus contains approximately 72% heterochromatin, while the irradiated nucleus contains only 64% heterochromatin. (author). 13 figs., 1 tab., 18 refs

  18. Short term toxicity of strawberry flavor and carmoisine color in male albino rats

    International Nuclear Information System (INIS)

    ElShamy, K.AI.; Morsy, F.A.; Elsheikh, E.A.B.; Hassanin, M.M.

    2003-01-01

    The objective of this study was to determine the potential toxicity associated with oral administrations of the strawberry flavor and carmoisine color. The tested materials were given to the animals in their drinking water. Biochemical parameters were determined in liver, kidney and brain DNA and RNA contents.Sera was used for liver and kidney functions, lipid profile and thyroid hormones estimation. Histopathological, histochemical and cytophotometric studies were performed in liver and kidney tissues. Equal weights of flavoring and coloring agents were mixed at 0.1% w/v with drinking water. Forty adult male albino rats were assigned to four equal groups, two groups were served as controls and the remaining two groups received standard diet and water containing the tested materials for three and six week. There were no deaths and all the studied parameters were affected in a time dependent manner. Liver DNA contents were significantly decreased, kidney DNA contents tended to increase and brain DNA contents were significantly increased only after 6 weeks of treatment. RNA contents were significantly decreased in liver and brain

  19. Activation and odor conditioning of suckling behavior in 3-day-old albino rats.

    Science.gov (United States)

    Pedersen, P E; Williams, C L; Blass, E M

    1982-10-01

    The circumstances under which a novel odor could elicit nipple attachment behavior in 3-day-old albino rats were investigated. In Experiment 1, rats suckled washed nipples scented with citral (a lemon odor) only if they either had received tactile stimulation (by stroking with a soft artist's brush) or had been administered amphetamine in the presence of citral prior to the suckling test. Pups stimulated in citral's absence or simply exposed to citral without stimulation failed to suckle such nipples. In Experiment 2, rats stimulated in a benzaldehyde (an almond odor) ambience suckled washed nipples scented with benzaldehyde but not those with citral scent. The opposite held for rats stimulated in a citral-rich environment. The stimulus conditions that support this conditioning were investigated in Experiment 3. Simultaneously increasing citral concentration and raising ambient temperature markedly attenuated the phenomenon. Experiment 4 demonstrated that not all classes of stimulation produced conditioning. Caffeine, in a wide range of doses, did not allow citral to elicit suckling on washed nipples. These findings are discussed within a framework of higher order conditioning. They may provide a mechanism by which naturally occurring stimuli come to elicit the species- and age-typical behavior of suckling.

  20. Immunomodulatory potential of Anacyclus pyrethrum (L.) and Mucuna pruriens (L.) In male albino rats.

    Science.gov (United States)

    Yousaf, F; Shahid, M; Riaz, M; Atta, A; Fatima, H

    2017-01-01

    The present study was designed to investigate the immunomodulatory potential of Anacyclus pyrethrum roots and Mucuna pruriens seeds in male albino rats. The roots of A. pyrethrum and seeds of M. pruriens were extracted with methanolic solvent (70:30) and administered at dose concentrations of 50, 100 and 200 mg/Kg body weight to healthy male rats. The immune system of rats was suppressed by injecting carbon tetrachloride to animals in the toxic control group and test group animals. Cell-mediated immune response of animals was examined by performing neutrophil adhesion test and the humoral immune response was evaluated by determining serum immunoglobulin levels of the animals under study. The administration of methanolic extracts of A. pyrethrum roots and M. pruriens seeds significantly (p less than 0.05) increased the neutrophil adhesion to the nylon fiber. Increase in % neutrophil adhesion was observed in animals treated with 200 mg of each plant extract. Significant (p less than 0.05) improvement in immunoglobulin levels was recorded in the extract treated group animals, showing that the root extract of A. pyrethrum and seed extract of M. pruriens have immunomodulatory potential. We therefore conclude that the tested extracts can be used as immunomodulatory agents to stimulate the immune system.

  1. Evaluation of Carrot Pomace (Daucus carota L. as Hypocholesterolemic and Hypolipidemic Agent on Albino Rats

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    Abd El-Moneim M.R. AFIFY

    2013-02-01

    Full Text Available The current study examined the attenuating influence of dietary carrot pomace powder (CaPP on hypercholesterolemia and various oxidative stress-associated with biochemical parameters in hypercholesterolemic rats. Thirty two male albino rats weighing 110±10 g were divided into four groups, the first group received the basal diet only and served as (negative control, the second group received the hypercholesterolemic diet and served as positive control, the other groups received hypercholesterolemic diet supplemented with 10%, 20% CaPP for six weeks. The obtained results revealed that groups supplemented with 10% and 20% CaPP significantly decrease total lipid, total cholesterol, triglycerides, low density lipoprotein cholesterol, liver enzymes: alanine aminotransferase, aspartate aminotransferase compared to positive and negative groups. Organs weight, body weight gain significantly decreased compared with positive control. Moreover dietary carrot pomace powder can used to reduce the body weight and reducing hypercholesterolemic complications. In addition, dietary carrot pomace powder serves to improve the blood picture and to reduce the blood glucose level in hypercholesterolemic rats and could use in obese people for body loss. Data of kidney function (Urea record an increase in CaPP 20% level (26.9±2.96 but this increase was non significant with the negative control group (26.6±3.1.

  2. In vivo immunomodulatory effects of the methanolic leaf extract of Gymnema sylvestre in Swiss albino mice

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    Ahirwal Laxmi

    2015-01-01

    Full Text Available In the present study we performed a comparative phytochemical analysis of the immunomodulating activities of the methanol leaf extract of Gymnema sylvestre (MLEGS in Swiss albino mice. The phytochemical screening conducted on MLEGS revealed the presence of several phytoconstituents, including saponins, alkaloids, glycosides, phenols, tannins, and flavonoids. Immunomodulatory activities were determined by hemagglutination antibody (HA titer and delayed-type hypersensitivity (DTH tests for determining specific and non-specific immune responses. Flow cytometric techniques were performed for the estimation of B lymphocytes (CD3 and CD19 and Th2 cytokines (IL-2, IFN-γ and IL-4. The response produced by oral administration of MLEGS elicited a significant reduction in a dose-related manner in the primary and secondary antibody response and DTH response. The response produced by oral administration of MLEGS elicited significant reduction in a dose-related manner in the primary and secondary antibody and DTH responses, with maximum reduction observed at 200 mg/kg-body wt. The maximal reductions in the production of CD3, CD19, IL-2, IFN-γ and IL-4 were 31.59, 32.12, 29.51, 32.45 and 33.53%, respectively, at 200 mg/kg body weight. This study demonstrates that G. sylvestre exerts immunosuppressive effects on the components of the immune system of mice, and points to its significant immunomodulatory potential.

  3. Embryotoxic and Teratogenic Effects of Nickel in Swiss Albino Mice during Organogenetic Period

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    Shivi Saini

    2013-01-01

    Full Text Available The present study evaluates potential hazardous of nickel (Ni+2 as NiCl2·6H2O to Swiss albino mice fetus. Ni was administered orally on body weight base from days 6 to 13 of gestation period. Based on LD50, Ni doses (46.125, 92.25, and 184.5 mg Ni/kg b.wt. were used. On day 18 of gestation, uteri of the sacrificed dams were examined. A dose-dependent decrease ( in the body weight of the pregnant females and fetuses during the gestation period was observed. Number of implant sites and placental weight at all the three dose levels was lower compared with their respective control groups. Average number of live fetuses/dams reduced significantly ( at 184.5 mg Ni/kg b.wt. with concomitant increase in the percentage of postimplantation death and percentage of resorbed, macerated, and dead fetuses, respectively. Exposure increased the fetal malformations, namely, hydrocephaly, open eyelids, microphthalmia, exophthalmia, club foot, umbilical hernia, and skeletal anomalies. Reduced ossification of nasal, frontal, parietal, intraparietal, and supraoccipital bones, absence/gap between the ribs, reduced/fused sternebrae, vertebral centra, and caudal vertebrae, reduced pelvic elements, absence of carpals, metacarpals, tarsals, metatarsals, and phalanges were distinct. This indicates vulnerability of the mice fetus to nickel during prenatal exposure.

  4. Antinociceptive Effect of Ondansetron in Albino Mice Using Acetic Acid Induced Writhing Model

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    Abhay Purohit

    2016-10-01

    Full Text Available Background: Pain is an unpleasant sensory and emotional experience. Pain is a protective mechanism. Pain occurs whenever any tissues are being damaged, and it causes the individual to react and to remove the pain stimulus. Aim and Objectives: To evaluate the antinociceptive effect of ondansetron in comparison with the standard diclofenac. Material and Methods: The antinociceptive effect was tested by using the acetic acid induced writhing model in Swiss Albino mice. Animals were divided into 4 groups of 6 animals each. Animals were received distilled water (control, diclofenac (standard, ondansetron 0.5mg/kg (test I and ondansetron 1mg/kg (test II. After 30 minutes of drug administration, 0.1 ml of 1% acetic acid was injected. Mice were placed individually into glass beakers and five minutes were allowed to elapse. They were then observed for a period of ten minutes and the numbers of writhes were recorded in each animal. The results were expressed as mean ± SEM. One way ANOVA with post-test was used for statistical calculation. Results: The numbers of writhes were 1.33±0.494 for diclofenac; 6.33±1.872 and 9.33±1.706 for ondansetron 0.5 and 1mg/kg respectively. Conclusion: Ondansetron demonstrated statistical significant antinociceptive activity at both doses (0.5mg/kg and 1mg/kg and statistically similar effect as diclofenac

  5. Tanacetum parthenium leaf extract mediated survival protection in lethally irradiated Swiss albino mice

    International Nuclear Information System (INIS)

    Shetty, Prashanth; Pooja, S.; Suchetha Kumari, N.; Shetty, Jayaram; Peter, Alex John; Jose, Jerish M.

    2016-01-01

    Search for less-toxic radioprotectors has spurred interest in the development of natural products. In Ayurveda, the traditional medicine, Tanacetum species have been used to treat ailments since ancient times throughout the world. Effects of the administration of different concentrations of Tanacetum parthenium leaf aqueous extract (TPLA), Tanacetum parthenium leaf ethanolic extract (TPLE) were investigated in Swiss albino mice. Mice (20-25 g) were randomly divided into 8 groups of ten animals each. The control group and the radiation group were treated daily with oral administration of saline for 15 days. Each subgroups of TPLA and TPLE were treated with doses of 50, 100 and 250 mg/kg daily for 15 days. On the 15th day, all were irradiated with 10 Gy whole body irradiation. Survival was observed daily up to 30th post-irradiation day. Data were analysed using the Kaplan-Meier survival curves. The significance difference in survival between control, radiation and treatment groups were observed (P < 0.001). Current studies revealed the protective effect of Tanacetum parthenium rendering high survivability in lethally irradiated mice. (author)

  6. Cadmium cytotoxicity in albino mice hepatocytes and its possible implications on tropical environments

    International Nuclear Information System (INIS)

    Marcano, Letty; Carruyo, Ingrid; Montiel, Xiomara; Faria, Clarisa de R.

    2006-01-01

    Analyzed phenotypic, structural and ultrastructural alterations induced by Cd +2 in hepatocytes extracted from Swiss Albino mice. Cadmium was given orally in watery solution of CdCl 2 during 100 days at concentrations of 50 ppm, 100 ppm and 150 ppm. In controls, distilled water alone was used. The samples were processed with the paraffin inclusion and hematoxylin-eosin coloration techniques for light microscopy. The conventional technique was used for transmission electron microscopy . Phenotypic (size and weight differences) and physiologic changes (muscular weakness, unrest) were found; at the structural level it was noticed loss of trabecular disposition and of lobular architecture, lymphocyte agglomeration, vacuolisation, dilatation of sinusoid and central vein, among others. The ultrastructural study evidenced alterations coincident with those seen with light microscopy, which were accentuated with the increase of metal concentration: nucleolus with a high number of fibrillar centers (50 ppm); voluminous lipidic drops in the cytoplasm, loose endoplasmic rough reticulum, cytoplasmic vacuolisation, altered lysosomes and peroxisomes (100 ppm); contracted nucleis with condensed chromatin, dilatation of intracellular space and mitochondria, and loss of fibrillar areas (150 ppm). Cadmium produces a toxic effect in the hepatic cells; the effect is more severe at higher concentration, leading to cellular necrosis. (author) [es

  7. Effect of parsley (Petroselinum crispum, Apiaceae) juice against cadmium neurotoxicity in albino mice (Mus musculus).

    Science.gov (United States)

    Maodaa, Saleh N; Allam, Ahmed A; Ajarem, Jamaan; Abdel-Maksoud, Mostafa A; Al-Basher, Gadah I; Wang, Zun Yao

    2016-02-04

    Parsley was employed as an experimental probe to prevent the behavioral, biochemical and morphological changes in the brain tissue of the albino mice following chronic cadmium (Cd) administration. Non-anesthetized adult male mice were given parsley juice (Petroselinum crispum, Apiaceae) daily by gastric intubation at doses of 10 and 20 g/kg/day. The animals were divided into six groups: Group A, mice were exposed to saline; Groups B and C, were given low and high doses of parsley juice, respectively; Group D, mice were exposed to Cd; Groups E and F, were exposed to Cd and concomitantly given low and high doses of parsley, respectively. Cd intoxication can cause behavioral abnormalities, biochemical and histopathological disturbances in treated mice. Parsley juice has significantly improved the Cd-associated behavioral changes, reduced the elevation of lipid peroxidation and normalized the Cd effect on reduced glutathione and peroxidase activities in the brain of treated mice. Histological data have supported these foundations whereas Cd treatment has induced neuronal degeneration, chromatolysis and pyknosis in the cerebrum, cerebellum and medulla oblongata. The low dose (5 g/kg/day) of parsley exhibited beneficial effects in reducing the deleterious changes associated with Cd treatment on the behavior, neurotransmitters level, oxidative stress and brain neurons of the Cd-treated mice.

  8. Effect of embelin on lithium-induced nephrogenic diabetes insipidus in albino rats

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    Ashish K Sahu

    2012-10-01

    Full Text Available Objective: To evaluate the nephroprotective and anti-polyuric role of embelin on lithium induced nephrogenic diabetes insipidus (NDI in albino rats. Methods: NDI induced by lithium chloride (4 meq/kg/day, i.p. for 6 days which leads to huge amount of urine excretion. After induction of NDI, embelin (50 and 100mg/kg was administered orally, once daily for 21 day in rats and N-acetyl cysteine (10mg/kg, twice daily, i.p. was used as a standard drug for treatment of NDI. The body weight, urine protein, urine creatinine, plasma creatinine, blood urea nitrogen were assessed at 0, 7, 14 and 21 day. At the end of the study glutathione (GSH content in kidney was assessed and histopathology of kidney was performed. Results: Embelin 50 and 100 mg/ kg showed increase in the body weight and decrease in plasma and urine creatinine, blood urea nitrogen levels, and urine protein level. Embelin acts as a potent antioxidant; it increases the level of glutathione in kidney. Histopathological examination of the kidney indicated that embelin 50 and 100 mg/kg were reduced the vascular degeneration of tubules as well as slight degeneration and dilatation of renal tubules, however N-actyl cysteine (NAC treated rats showed normal glomeruli and renal tubule with slight degeneration. Conclusions: Embelin seemed to be effective in NDI by its predominant effect on promoting antioxidant status and decrease the urine excretion may be due to the blocking of sodium channels.

  9. Gut Microbiota Confers Resistance of Albino Oxford Rats to the Induction of Experimental Autoimmune Encephalomyelitis.

    Science.gov (United States)

    Stanisavljević, Suzana; Dinić, Miroslav; Jevtić, Bojan; Đedović, Neda; Momčilović, Miljana; Đokić, Jelena; Golić, Nataša; Mostarica Stojković, Marija; Miljković, Đorđe

    2018-01-01

    Albino Oxford (AO) rats are extremely resistant to induction of experimental autoimmune encephalomyelitis (EAE). EAE is an animal model of multiple sclerosis, a chronic inflammatory disease of the central nervous system (CNS), with established autoimmune pathogenesis. The autoimmune response against the antigens of the CNS is initiated in the peripheral lymphoid tissues after immunization of AO rats with CNS antigens. Subsequently, limited infiltration of the CNS occurs, yet without clinical sequels. It has recently become increasingly appreciated that gut-associated lymphoid tissues (GALT) and gut microbiota play an important role in regulation and propagation of encephalitogenic immune response. Therefore, modulation of AO gut microbiota by antibiotics was performed in this study. The treatment altered composition of gut microbiota in AO rats and led to a reduction in the proportion of regulatory T cells in Peyer's patches, mesenteric lymph nodes, and in lymph nodes draining the site of immunization. Upregulation of interferon-γ and interleukin (IL)-17 production was observed in the draining lymph nodes. The treatment led to clinically manifested EAE in AO rats with more numerous infiltrates and higher production of IL-17 observed in the CNS. Importantly, transfer of AO gut microbiota into EAE-prone Dark Agouti rats ameliorated the disease. These results clearly imply that gut microbiota is an important factor in AO rat resistance to EAE and that gut microbiota transfer is an efficacious way to treat CNS autoimmunity. These findings also support the idea that gut microbiota modulation has a potential as a future treatment of multiple sclerosis.

  10. [Experimental model of activated Lamblia (Giardia) muris infection in albino mice].

    Science.gov (United States)

    Irikov, O A; Kovalenko, F P

    2007-01-01

    Experimental L. muris infection was reproduced in 100% of the intact albino mice intragastrically given levomycin in an average total dose of 15.88-34.84 or 0.88-1.02 g/kg for 18-34 days. With levomycin administration, the intensity of giardiasis was 1121.6-8540.1 (mean 4830.9) thousand L. muris trophozoites per animal. The total number of trophozoites per animal decreased to 302.2-3481.4 (mean 1546.4) thousand and 28.1-324.0 (mean 109.4) thousand specimens 5-8 and 11-13 days after discontinuation of the antibiotic, respectively. The maximum number of L. muris trophozoites was observed in the proximal and middle portions of the murine small intestine during and after the administration oflevomycin. The highest isolation of cysts was seen 12-14 days after the initiation of administration of the antibiotic. Following 8-10 days of terminations of a course of levomycin therapy the native smear of animal feces showed no Lamblia cysts. In mice with activated infection, the isolation rate of Lamblia cysts was directly related to the intensity of intestinal infection with trophozoites of the parasite.

  11. Acute toxicity study of Vilocym Premix (herbal growth promoter for Livestockin Wistar Albino Rat

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    A.H. Ahmad

    2009-06-01

    Full Text Available An experimental study with the objective of safety evaluation of Vilocym Premix, herbal growth promoter for Livestock (supplied by Ayurvet Ltd., Baddi, India, was done as per standard guidelines of OECD-423 for acute toxicity testing. Vilocym Premix is a scientifically developed combination of herbs that contains herbal ingredients namely Azadirachta indica, Curcuma longa & many more alongwith natural zeolites. The study was done in 3 males and 3 female Wistar Albino rats, which were administered an initial dose of 50 mg/kg body weight followed by dose rates of 300, 500 & 5000 mg/kg body weight of test compound. The animals were observed for signs of convulsions, tremors, circling, depression, excitement and mortality. Body weight was recorded at 0,7th and 14th day and plasma total protein, albumin; AST and ALT were measured after 3rd day of experiment. No abnormal sign of symptoms were observed in any of the animal fed with Vilocym Premix at the dose rate of 50, 300, 500 & 5000 mg/kg. No mortality was observed indicating safety of herbal premix. [Vet. World 2009; 2(3.000: 100-102

  12. Can homemade alcohol (Raksi) be useful for preserving dead bodies? An experiment on wistar albino rats.

    Science.gov (United States)

    Dhungel, S; Maskey, D; Jha, C B; Bhattacharya, S; Paudel, B H; Shrestha, R N

    2007-01-01

    Embalming is the through disinfection and art of preserving bodies after death using chemical substances. It keeps a body life like in appearance during the time it lies in a state prior to funeral. This study was undertaken to investigate the effectiveness of Raksi in sacrificed rats in arresting postmortem changes and establishing scientific fact whether Raksi can be an alternative to standard embalming constituent if it is not available. 50 albino rats were systematically randomized into control and experiment groups. Raksi and distilled water were injected for embalming purpose intraventricularly in experiment and control groups of rats respectively and kept for 48 to 96 hours for observation for postmortem changes. Observations made at 48 and 72 hours of embalming revealed that Raksi can arrest postmortem changes in the rats up to 72 hours (3rd day) successfully in the experimental group whereas moderate to severe postmortem changes were seen in the control group. The experimental group showed mild degree of putrefactive changes, liberation of gases and liquefaction of tissues only at 96 hours (4th day) of embalming. The Raksi used in this experiment contained 34% of alcohol, which was determined by an alcohol hydrometer. Experiment clearly demonstrated from its result that raksi can be utilised temporarily for embalming since it contains alcohol and has preservative, bactericidal and disinfectant properties. It is concluded from the study that this knowledge if applied to dead human subjects, may preserve dead bodies temporarily allowing delayed funeral.

  13. Rectification of radiation-induced damage in swiss albino mice by aloe vera leaf extracts (AVE)

    International Nuclear Information System (INIS)

    Gehlot, P.; Goyal, P. K.

    2007-01-01

    From the time immemorial man has been exposed to ionizing radiation from the environment in which he lives. Radiation protection concepts and philosophy have been evolving over the past several decades. Materials and Methods: The radioprotective of effect of Aloe vera leaf extract (1000 mg/kg b.wt. orally for 15 consecutive days) has been studied against 6 Gy of gamma radiation in the intestine of Swiss albino mice at various post irradiation intervals viz. 12 hours, 24 hours. and 3, 5, 10, 20 and 30 days. Results: Crypt survival, villus length, apoptic cells, mitotic figures and goblet cells in jejunum were studied after irradiation. Irradiation produced a significant decrease in crypt survival, mitotic figures and villus length; whereas goblet and apoptic cells showed a significant increase from sham irradiated animals. The major changes were observed on day 3 after irradiation. AVE pre-treated irradiated animals resulted in a significant increase in the number of crypt cells, mitotic figures and villus length; whereas the counts of apoptic and goblet cells showed a significant decrease from respective control group at all the autopsy intervals. Irradiated animals resulted in the elevation in lipid peroxidation and a reduction in glutathione activity. On contrary, AVE treatment before irradiation caused a significant depletion in lipid peroxidation and elevation in glutathione activity. Conclusion: The present study suggests the possible radioprotective ability of Aloe vera leaf extract

  14. Antioxidant activity of lycopene extracted from tomato pomace toward gamma irradiation hazards in male albino rats

    International Nuclear Information System (INIS)

    Saad, T.M.M.; EL MASRY, F.S.

    2005-01-01

    The present study aims to evaluate the anti oxidative activity of lycopene extracted from tomato pomace against hazards induced by gamma irradiation. Male Swiss albino rats were orally administered by lycopene (1.2 mg/rat/day) using suitable stomach tube 7 days before exposure to a sublethal single dose (6.5 Gy) of whole body gamma radiation. Lipid peroxides (MDA) levels in plasma, reduced glutathione (GSH) content and superoxide dismutase activity in blood were determined, as well as serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma glutamyl transferase activity (GGT) were investigated 7 and 15 days post-irradiation and/or lycopene administration. The results revealed that exposure to ionizing radiation resulted in significant elevation in plasma levels of MDA, serum ALT, AST, ALP and GGT, as well as significant reduction in GSH content and superoxide dismutase activity in blood. Administration of lycopene by using suitable stomach tube pre-irradiation has significantly ameliorated the radiation-induced disturbances in all the investigated parameters

  15. Sub-acute toxicological effects of Jobelyn on pregnant albino rats

    Science.gov (United States)

    Adebayo, Abiodun Humphrey; Yakubu, Omolara Faith; Egbung, Godwin Eneji; Williams, Olabisi Ibidun; Okubena, Olajuwon

    2018-04-01

    The aim of the present study was to investigate the sub-acute toxicological effects of Jobelyn® on pregnant albino rats by employing biochemical, haematological and histopathological methods. A total of 32 pregnant female rats were randomly assigned to four different groups of eight rats each. The control group received distilled water and different doses of Jobelyn®; 250, 500, 1000 mg kg-1 were administered orally once a day for 2 weeks to the other groups. Biochemical analysis revealed a significant decrease (pAlkaline phosphatase, total protein, triglycerides, cholesterol, HDL cholesterol, LDL cholesterol, eosinophils, basophils, neutrophils, monocytes, lymphocytes, WBC count, revealed no significant difference (p<0.05) when compared to the control. The results show that at an appropriate dosage, the use of Jobelyn® during pregnancy may have no adverse effect on the liver and kidney tissues and may possess hepatoprotective and nephroprotective properties however the histopathological studies revealed that very high levels of Jobelyn may be hepatotoxic.

  16. Effect of granulosis virus (virotecto) as bioinsecticide on some biochemical changes in male albino rats

    International Nuclear Information System (INIS)

    Mohamed, N.E; Ali, S.E

    2009-01-01

    The objective of this study to determine the biochemical response of granulosis virus in male albino rats fed with potato treated with granulosis virus (0.15 g/Kg) against potato tuber moth in stores .It was carried out by evaluating the effect of daily feeding on treated potato for 5 weeks followed by withdrawal period for 10 days fed with normal diet on some biochemical and histological changes in kidney of male rats. A trail consists of 3 groups each one contain 18 rats, the first group fed on normal basal diet and served as control, the second group fed with 50% normal potato and 50% basal diet (potato group) and the third group fed with 50% basal diet and 50% potato treated with granulosis virus (virus group) through the experimental period. The obtained data revealed a significant reduction in final body weight and organs weight in both normal and treated potato groups. Sera collected at 2 and 5 weeks post feeding and at the end of withdrawal period, recorded significant disorders in some tested parameters. In addition, histological examination of kidney tissue showed different disorders in normal and treated groups.

  17. Radiomodification by Aloe vera leaf extract on skin of Swiss albino mice exposed to gamma radiation

    International Nuclear Information System (INIS)

    Gehlot, Prashasnika; Soyal, Dhanraj; Goyal, P.K.

    2007-01-01

    The development of effective radioprotectors and radiorecovery drugs is of great importance in view of their potential application during both planned (e.g. radiotherapy) and unplanned (e.g. in nuclear industry, natural background radiation emanating from the earth or other sources) radiation exposure. Over the past 50 years, research in the development of radioprotectors has focused on screening a plethora of chemical and biological compounds. Several synthetic chemical compounds have been tested for protection against radiation. But they have limited use due to inherent toxicity. Herbal medicine is still the mainstay of about 75-80 percent of the world population mainly in the developing nations for primary health care because of better cultural acceptability, better compatibility with the human body and lesser side effects. Thus, natural products offer an alternative to their synthetic counterparts due to low toxicity with no side effects. The present investigation has been an attempt to asses the radioprotective efficacy of Aloe vera leaf extract on biochemical alterations in skin of Swiss albino mice

  18. Protective Role Of Fresh Pomegranate Against Oxidative Damage In Whole Body Gamma Irradiated Male Albino Rats

    International Nuclear Information System (INIS)

    Kassab, F.M.A.; Taha, M.S.

    2013-01-01

    Twenty four male albino rats, body weight 100-130 g, were used to evaluate the protective role of fresh pomegranate fruit intake for 30 days on the damage induced by single dose of 6 Gy whole body gamma irradiation. The rats were randomly and equally divided into four groups: group (1): control, group (2): irradiated with 6 Gy, group (3): pomegranate for 30 days and group (4): pomegranate for 30 days followed by 6 Gy whole body irradiation. At the end of the experiment, all rats were sacrificed after 12 hours fasting then sera were separated for the determination of sugar, total antioxidant, lipid profile and liver and kidney functions. Results showed that gamma radiation caused significant decline (P<0.05) in serum total antioxidant, total protein, albumin, HDL-C and blood glucose with significant elevation (P<0.05) in other hepato-renal markers in addition to serum total cholesterol, triglycerides and LDL-C. These changes were significantly attenuated in irradiated animals pre-treated with whole fresh pomegranate fruit leading to the conclusion that pre-intake of pomegranate fruit had a radio- protective effect. This protection of this whole fruit may be due to the increased total antioxidant level leading to free radical scavenging

  19. NEUROPHYSIOLOGICAL STUDY ON THE EFFECT OF ARTIFICIAL FOOD COLOUR AND SWEETENER IN ADULT MALE ALBINO MICE

    International Nuclear Information System (INIS)

    ABDEL-RAHMAN, M.; EL-KHADRAGY, M.F.; ABDEL-AZIZ, R.L.

    2008-01-01

    This study aims to investigate the effect of aspartame (artificial sweetener) and sunset yellow (artificial colour) on monoamines content in different brain areas of the adult male albino mice (cerebellum, brain stem, striatum, hypothalamus and cerebral cortex), and also on testosterone level in serum.The present study showed that the daily intraperitoneal injection of aspartame with dose of 200 mg/kg caused significant increase in monoamines content and testosterone level at most experimental periods. The elevation of monoamines content may be due to increase in phenylalanine concentration which leading to increase the synthesis of monoamines. The elevation of testosterone level may be due to the increment of DA content in hypothalamus which led to increase the release of LHRH. On the other hand, the daily intraperitoneal injection of sunset yellow with a dose of 2.5 mg/kg caused significant decrease in monoamines content and non-significant change in serum testosterone level at most experimental periods. The decrement in monoamines content may be due to the decrease in its uptake by the neurotransmitters or decrease in its synthesis

  20. Gross hepatic changes in developing albino rats exposed to valproic acid

    International Nuclear Information System (INIS)

    Khan, M.; Khattak, S.T.; Elahi, M.

    2011-01-01

    Background: Valproid Acid (VPA) is a broad spectrum antiepileptic drug. Its use during pregnancy has been associated with congenital anomalies and hepatotoxicity. This study was designed to assess the effects of VPA on the gross structure of liver in developing albino rats exposed to the drug during various trimesters of pregnancy. Methods: In this experimental study 40 pregnant rats were divided into 4 equal groups A, B, C and D. Group A received VPA in a dose of 500 mg/Kg/day intraperitonealy (I/P) on days 3, 4 and 5 of gestation. Group B received the drug in a dose of 500 mg/Kg/day I/P on days 8, 9 and 10 of gestation. Group C received VPA in a dose of 500 mg/Kg/day I/P on days 16, 17 and 18 of gestation. Group D received no treatment and was kept as a control group. On day 21, the rats were euthanised by cervical dislocation. The liver of the foetuses were dissected out for the assessment of their gross structure. Results: Foetal liver of the experimental groups showed significant decrease in weight as well as relative tissue weight index (RTWI) as compared to the control group, although the gross appearance of the foetal liver was normal in all the groups. Conclusion: The use of VPA during various trimesters of pregnancy produces hepatotoxicity in the developing rats. So, the use of this drug during pregnancy should be carefully decided. (author)

  1. Evaluation of the aphrodisiac activity of Tribulus terrestris Linn. in sexually sluggish male albino rats

    Science.gov (United States)

    Singh, Surender; Nair, Vinod; Gupta, Yogendra K.

    2012-01-01

    Objectives: To study the effect of acute and repeated dose administration of lyophilized aqueous extract of the dried fruits of Tribulus terrestris (LAET) on sexual function in sexually sluggish male albino rats. Materials and Methods: Aphrodisiac activity of the test drug was evaluated in terms of exhibited sexual behavior. In order to assess the effect of chronic T. terrestris exposure on the hypothalamus--pituitary--gonadal axis, testosterone level estimation and sperm count were carried out. Twenty-eight-day oral toxicity studies were carried out to evaluate the long-term effects of the LAET administration on different body systems. Results: A dose-dependent improvement in sexual behavior was observed with the LAET treatment as characterized by an increase in mount frequency, intromission frequency, and penile erection index, as well as a decrease in mount latency, intromission latency, and ejaculatory latency. The enhancement of sexual behavior was more prominent on chronic administration of LAET. Chronic administration of LAET produced a significant increase in serum testosterone levels with no significant effect on the sperm count. No overt body system dysfunctions were observed in 28-day oral toxicity study. Conclusions: Findings of the present study validate the traditional use of T. terrestris as a sexual enhancer in the management of sexual dysfunction in males. PMID:22368416

  2. Effect of Perilla frutescens Fixed Oil on Experimental Esophagitis in Albino Wistar Rats

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    Ekta Arya

    2013-01-01

    Full Text Available The present study was undertaken to elucidate the effect of Perilla frutescens fixed oil on experimental esophagitis in albino rats. A group of rats (n=6, treated with control vehicle (0.9% NaCl in double distilled water, 3 mL/kg, i.p. and Perilla frutescens fixed oil (100% (1, 2, and 3 mL/kg, i.p., or pantoprazole (30 mg/kg, i.p., were subjected to pylorus and forestomach ligation. Animals were sacrificed after 6 h and evaluated for the gastric pH, volume of gastric juices, total acidity, esophagitis index and free acidity. Esophageal tissues were further subjected to estimations of TBARS, GSH, catalase, and SOD. Treatment with fixed oil significantly inhibited the gastric secretion, total acidity, and esophagitis index. The oil also helped to restore the altered levels of oxidative stress parameters to normal. The present study also makes evident the in vitro antihistaminic and anticholinergic activity of alpha linolenic acid (ALA (18 : 3, n−3 on isolated rat ileum preparation. The lipoxygenase inhibitory, histamine antagonistic, antisecretory (anticholinergic, and antioxidant activity of the oil was attributed for its efficacy in reflux esophagitis.

  3. Effect of gasoline fumes on reproductive function in male albino rats.

    Science.gov (United States)

    Owagboriaye, Folarin O; Dedeke, Gabriel A; Ashidi, Joseph S; Aladesida, Adeyinka A; Olooto, Wasiu E

    2018-02-01

    The increase in the frequency of exposure to gasoline fumes and the growing incidence of infertility among humans has been a major concern and subject of discussion over the years in Nigeria. We therefore present the reproductive effect of gasoline fumes on inhalation exposure in 40 male albino rats. The rats were randomized into five experimental treatments (T) with eight rats per treatment. T1 (control) was exposed to distilled water while T2, T3, T4, and T5 were exposed to gasoline fumes in exposure chambers for 1, 3, 5, and 9 h daily respectively for 12 weeks. Serum level of testosterone, follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, oxidative stress markers in the testicular tissue, epididymal sperm health assessment, and testicular histopathology of the rats were used as a diagnostic marker of reproductive dysfunction. Significant (p percentage motility in the exposed rats were observed. Significant (p < 0.05) increased in abnormal sperm cells characterized by damaged head, bent tail, damaged tail, and without head were also observed in the exposed rats. Histopathologically, severe degenerative testicular architectural lesions characterized by alterations in all the generations of sperm cells and reduction of interstitial cells were seen in the exposed rats. Gasoline fume is thus said to interfere with spermatogenesis and impair fertility in male gonad.

  4. Experimental transmission of Trypanosoma cruzi through the genitalia of albino mice

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    Leidi Herrera

    2001-07-01

    Full Text Available Trypanosoma cruzi is usually transmitted by contact with the excreta of infected Triatominae; among non-vectorial infections, direct transmission through coitus has been proposed. We investigated this possibility by instilling, through the external meatus of the vagina and the penis of previously anesthetized NMRI albino mice, blood of mice infected with strains isolated from Didelphis marsupialis (opossum, strain CO57, Rattus rattus (rat, strain CO22 and human (strain EP. Some animals were allowed to copulate the same day of the instillation. In other experiments, the strains were inoculated in the scrotum. To determine the effect of immunosuppression, some mice were treated with cyclophosphamide 30 days post-instillation. Controls were instilled orally and ocularly. Vaginal instillation with strain CO22 produced systemic infection with tropism to the heart, skeletal muscle, skin, duodenum, pancreas, ovary and sternum. Scrotal inoculation with strain EP likewise invaded liver, spleen, lung, lymph nodes and urogenital organs; while strain CO57 invaded skeletal and cardiac muscle, pancreas, testis, and vas deferens. Penile infection with strain CO22 was detected by xenodiagnosis. Immunosuppression did not increase parasitemia of vaginally infected mice or controls. Mating did not produce infection. Our results show that contact of blood trypomastigotes of T. cruzi with genital mucosa can produce blood and tissue infections. These results are discussed in relation to reports of frequent experimental tropism of T. cruzi toward urogenital organs.

  5. Assessment of Immunotoxicity of Dextran Coated Ferrite Nanoparticles in Albino Mice

    Science.gov (United States)

    Syama, Santhakumar; Gayathri, Viswanathan; Mohanan, Parayanthala Valappil

    2015-01-01

    In this study, dextran coated ferrite nanoparticles (DFNPs) of size immunotoxicity, and oxidative stress by in vitro and in vivo methods. Cytotoxicity was performed in vitro using splenocytes with different concentrations of DFNPs. Gene expression of selected cytokines (IL-1, IL-10, and TNF β) secretion by splenocytes was evaluated. Also, 100 mg of DFNPs was injected intraperitoneally to 18 albino mice for immunological stimulations. Six animals each were sacrificed at the end of 7, 14, and 21 days. Spleen was subjected to immunotoxic response and liver was analyzed for antioxidant parameters (lipid peroxidation, reduced glutathione, glutathione peroxidase, superoxide dismutase, and glutathione reductase). The results indicated that DFNPs failed to induce any immunological reactions and no significant alternation in antioxidant defense mechanism. Also, mRNA expression of the cytokines revealed an increase in IL-10 expression and subsequent decreased expression of IL-1 and TNF β. Eventually, DNA sequencing of liver actin gene revealed base alteration in nonconserved regions (10–20 bases) of all the treated groups when compared to control samples. Hence, it can be concluded that the DFNPs were nontoxic at the cellular level and nonimmunotoxic when exposed intraperitoneally to mice. PMID:26576301

  6. Influence of chewing behaviour on memory and spatial learning in albino BALB/c mice.

    Science.gov (United States)

    Aguirre Siancas, E E

    2017-05-01

    Since the relationship between chewing and cognitive functions has not been fully elucidated, this study aimed to determine the impact of chewing behaviour on spatial learning and memory in albino male BALB/c mice. Twenty mice aged 8 weeks were divided into 2 equal groups. The regular chewing group was fed with uncrushed grains (the same diet given to all 20 mice since they were weaned) and the limited chewing group was fed with crushed grains. At 16 weeks of age, the mice were evaluated over 5 days, including a 4-day acquisition phase prior to a probe test of spatial learning and memory in the Morris water maze on the fifth day. A comparison of the regular chewing group and the limited chewing group found no significant differences in either the acquisition phase or the probe test. However, there were significant differences in the acquisition phase for just the regular chewing group when comparing results from the first day to those from the other 3 days. The results suggest that regular chewing affects spatial learning and memory since mice in the regular chewing group decreased their times to find the hidden platform during the acquisition phase. Copyright © 2015 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  7. Hematological and histopathological changes in female albino rats after gamma irradiation and /or piper nigrum treatment

    International Nuclear Information System (INIS)

    Ali, S.E.; Hanna, L.S.; Khattab, H.M.

    2003-01-01

    This study was carried out to investigate the effect of whole body gamma irradiation, at dose level of 6.0 Gy (single dose), and or daily treatment with P. nigrum (black pepper) at doses of 160 and 320 mg/kg body weight up to 36, 71 and 99 days on some hematological aspects as well as histopathological changes in lung, kidney and brain tissues of female albino rats. The results revealed that whole body gamma irradiation significantly elevated the values of red blood cells (RBCs), white blood cells (WBCs) and hematocrit percentage (HC %) but hemoglobin level was significantly decreased. These changes were ameliorated after treatment with P. nigrum. Non-significant changes were obtained regarding the effect of both doses of P. nigrum on red and white blood cell counts throughout the three time intervals. However, a dose of 160 mg/kg body weight of P. nigrum significantly reduced the hemoglobin contents throughput the experimental period. Histopathological examination revealed that lung, kidney and brain tissues showed marked to moderate pathological changes after irradiation and/or P.nigrum treatments. However, treatment with P. nigrum showed positive effect against the harmful effects of gamma irradiation, concerning kidney and brain. Although no malignant transformation could be detected, the resultant marked alveolar inflammation, bronchial wall hyperplasia and reactive astrocytic proliferation are important pathological changes that should be considered as pre-neoplastic changes

  8. Biosíntesis de dextranos de alto peso molecular mediante la inoculación con Leuconostoc Mesenteroides, var. Mesenteroides (atcc 10830 de jugos residuales de la agroindustria de la piña: síntesis y caracterización de hierro-dextranos

    Directory of Open Access Journals (Sweden)

    José Roberto Vega Baudrit

    2013-01-01

    Full Text Available En este trabajo se muestran los estudios realizados para obtener dextranos a partir de desechos de la agroindustria de piña. La fermentación se llevó a cabo en un biorreactor (10 L, se inoculó con un cultivo de Leuconostoc mesenteroides, var. mesenteroides (ATCC 10830. Se centrifugó y se precipitó y purificó con etanol. Fue caracterizado por medio de viscosidad, peso molecular y grupos funcionales por espectroscopía infrarroja. Este dextrano fue tratado con el fin de obtener hierro-dextranos.

  9. Tubo gástrico con conservación anatómica y funcional del píloro Gastric tube with anatomical and functional conservation of the pylorus

    OpenAIRE

    Albio Ferrá Betancourt; Sixto Corona Mancebo

    2008-01-01

    INTRODUCCIÓN. No existe consenso en cuanto a la realización de un procedimiento de drenaje gástrico cuando se ha realizado una esofagectomía subtotal y se ha sustituido el esófago por el estómago tubulizado y desnervado. Es el objetivo de este estudio evaluar el resultado obtenido en pacientes a quienes se practicó esofagectomía subtotal y sustitución del órgano con estómago tubulizado sin aplicar drenaje gástrico (piloroplastia). MÉTODOS. Se analizaron 16 pacientes tratados con este procedim...

  10. Fracturas de clavícula. Tratamiento quirúrgico con clavos intramedulares flexibles

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    Roberto Joaquín Del Gordo D'amato

    2014-05-01

    Full Text Available Se realizó un estudio de tipo descriptivo en una serie de casos en el cual se presentan los resultados de 12 fracturas de clavícula tratadas en forma quirúrgica mediante clavos intramedulares flexibles. Todos los pacientes fueron tratados por los autores en la Clínica El Prado del D.T.C.H. de la Ciudad de Santa Marta mediante reducción cerrada bajo control radioscópico. Presentando resultados excelentes y buenos en todos los casos. Así mismo, se evidenció consolidación clínica a las cuatro semanas con reintegro a la vida laboral alrededor de las seis semanas. Todos los pacientes mostraron alto grado de satisfacción con el resultado obtenido. Se concluye que el tratamiento empleado es una alternativa terapéutica a tener en cuenta en aquellas fracturas desplazadas, sean estas del tercio externo, medio o interno que permite consolidación sin las complicaciones que con alguna frecuencia se presentan con el tratamiento conservador. (Duazary 2006; 2:115-120

  11. Qualidade pós-colheita de quivi 'Hayward' tratado com 1-MCP e armazenado sob diferentes atmosferas

    Directory of Open Access Journals (Sweden)

    Marcelo José Vieira

    2012-06-01

    Full Text Available Este trabalho teve por objetivo avaliar o efeito do 1-MCP sobre o amadurecimento e a qualidade pós-colheita de quivi 'Hayward' armazenado sob diferentes atmosferas. Foram conduzidos dois experimentos, com frutos colhidos em pomar comercial localizado em Fraiburgo-SC. No experimento 1, os frutos foram tratados com três doses de 1-MCP (0,0; 0,5 ou 1,0 µL L-1 e armazenados sob atmosfera controlada (AC, contendo 2,0kPa de O2 + 4,5kPa de CO2, a 0ºC ± 0,5ºC, 92 ± 3% UR, e com <40 ηL L-1 de etileno no ambiente, durante 90 e 120 dias, mais sete dias de vida de prateleira a 23ºC. No experimento 2, os frutos foram tratados com 0,0 ou 0,7 µL L-1 de 1-MCP e armazenados sob atmosfera ambiente (AA, contendo 21 kPa de O2 + 0,03 kPa de CO2, a 0 ± 0,5ºC, 90 ± 3% UR, e com 200 a 250 ηL L-1 de etileno no ambiente, durante 30, 60, 90 e 120 dias, mais um e sete dias de vida de prateleira a 23ºC ou AC (contendo 2,0 kPa de O2 + 4,5 kPa de CO2, a 0ºC ± 0,5ºC, 92 ± 3% UR, e com <40 ηL L-1 de etileno no ambiente, durante 60, 90, 120 e 150 dias, mais um e sete dias de vida de prateleira a 23ºC. Os benefícios do tratamento com 1-MCP sobre a conservação da qualidade foram observados tanto para frutos armazenados sob AA quanto sob AC. No experimento 1, não houve diferença entre as doses de 1-MCP de 0,5 e 1,0 µL L-1 sobre o controle do amadurecimento e manutenção da qualidade dos frutos armazenados em AC. No experimento 2, o tratamento com 1-MCP retardou o aumento na taxa de produção de etileno após remoção de câmara fria. A redução da taxa de produção de etileno nos frutos tratados com 1-MCP foi associada ao aumento na conservação da firmeza da polpa sob AC e AA, e redução na incidência de pericarpo translúcido sob AA. O potencial de armazenamento foi aumentado pelo tratamento com 1-MCP em aproximadamente 60 e 30 dias, nos frutos armazenados sob AA e AC, respectivamente.

  12. Características in vivo del epitelio corneal versus magnitud del defecto refractivo, posterior a tratamiento con láser de excímeros

    Directory of Open Access Journals (Sweden)

    Eduardo Rojas Álvarez

    Full Text Available Objetivo: describir las características in vivo del epitelio corneal y su relación con la magnitud del defecto refractivo tratado posterior al tratamiento quirúrgico de LASIK. Método: estudio descriptivo, prospectivo-longitudinal con 24 pacientes (48 ojos con astigmatismo miópico intervenidos con el ESIRIS (Schwind-Alemania por la técnica quirúrgica LASIK con microquerátomo pendular. Se analizaron los resultados a partir de técnicas de estadística descriptiva. Se utilizó el microscopio confocal ConfoScan 4 de NIDEK para la obtención y estudio de las imágenes in vivo de tejido corneal. Resultados: el grosor epitelial central medio en el preoperatorio fue 34,7 mm, a los 7 días del posoperatorio hubo un incremento del 36 % en pacientes con defectos refractivos inferiores a 4D y un incremento del 44 % en pacientes con defectos refractivos de 4 D o más. El promedio de densidad de células del epitelio basal a los 7 días fue de 5 098,3±1 654 células/mm², tuvo variaciones mínimas inferiores a la unidad porcentual durante la etapa de estudio. Conclusiones: existió incremento del grosor epitelial posterior a LASIK que fue superior en defectos refractivos mayores de 4 dioptrías. La densidad celular del epitelio basal no tuvo variaciones significativas y fue independiente a la magnitud del defecto refractivo tratado.

  13. Cementos con cenizas volantes

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    Ossa M., Mauricio

    1984-03-01

    additions of 20 and 30% .

    Casi la generalidad de los estudios realizados sobre cementos con adición de cenizas volantes se refieren a sus características y comportamiento en pastas, morteros y hormigones, siempre en relación con aquéllos del cemento portland. Esta vez, se desarrolló un trabajo experimental orientado a relacionar entre sí los cementos con adiciones de cenizas volantes y de puzolana natural. Para ello se fabricaron a escala de laboratorio cementos de ambos tipos, empleando como materias primas comunes clinker y yeso y, como variables, diferentes porcentajes de las dos adiciones, que cumplieron previamente los requisitos normalizados en cuanto a sus actividades puzolánicas. La calidad de los cementos fabricados resultó adecuada y concordante con la del cemento portland-puzolánico obtenido a escala industrial con los mismos clinker, yeso y puzolana natural de este estudio. Posteriormente, se determinaron las características de los cementos experimentales y se confeccionaron morteros normales para la realización de ensayos físicos y mecánicos. Los resultados de ensayos indicaron que los cementos con adición de cenizas volantes (CCV requieren menos agua para consistencia normal, presentan tiempos de fraguado mayores y expansiones en autoclave menores que los cementos con adición de puzolana (CP. Los calores de hidratación a 7 y 28 días de edad fueron aproximadamente similares para ambos tipos de cemento. En morteros normales, los cementos CCV mostraron menor retracción de secado, mayor retentividad y mayor fluidez (para igual cantidad de agua que los cementos CP. En los ensayos de exudación se observó que ésta depende más de la finura que el tipo de adición. Finalmente, los ensayos mecánicos señalaron que las resistencias a compresión y flexotracción de los morteros con cementos CCV son menores a edades inferiores que 14 días (del orden de 5 a 10% a un día de edad, pero que a partir de entonces pasan a ser mayores que las de

  14. Perfil eletrocardiográfico e conteúdo glicogênico muscular de ratos tratados com nandrolona

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    Carlos Alberto da Silva

    2010-12-01

    Full Text Available FUNDAMENTO: Considerou-se o uso indiscriminado de esteroides tanto por atletas de elite quanto por praticantes de atividades físicas. OBJETIVO: Avaliar os efeitos do decanoato de nandrolona sobre o perfil eletrocardiográfico, conteúdo glicogênico e de proteínas totais dos músculos cardíacos e esqueléticos, bem como as concentrações plasmática de albumina. MÉTODOS: Os animais do grupo tratado receberam a droga na concentração 5 mg/kg pela via subcutânea, duas vezes por semana, durante três semanas. Uma vez por semana, os ratos foram anestesiados com Pentobarbital sódico (50 mg/kg, ip e submetidos à avaliação por meio do eletrocardiograma (ECG. Após o período experimental, amostras dos músculos cardíaco (ventrículo esquerdo - VE, sóleo (S, gastrocnêmio branco (GB, gastrocnêmio vermelho (GV, peitoral (P, intercostal (IC e diafragma (D foram prontamente coletadas e analisadas. Os dados (média ± epm foram avaliados de acordo com ANOVA, segundo teste de Tukey (p>0,05. RESULTADOS: Os ratos do grupo tratado apresentaram alterações nos seguintes parâmetros cardíacos: intervalo QRS, intervalo QTc e frequência cardíaca, caracterizados por um aumento desses, tendo o ápice no intervalo da semana de pré-tratamento para a primeira semana. As reservas de glicogênio no VE apresentaram aumento de 127%. Em relação à quantidade de proteínas totais, a diferença significativa foi constatada no S, GV e D. Quanto ao perfil bioquímico e ao hematócrito, foi observado um aumento na porcentagem de eritrócitos. CONCLUSÃO: O estudo mostra que importantes alterações cardíacas são deflagradas precocemente, sugerindo uma hierarquia na sequência de modificações que comprometem a homeostasia do organismo.

  15. Efectividad e impacto económico de un programa de atención integrada con soporte de telemedicina a pacientes diabéticos tipo 2 tratados con insulina (estudio GITDIABE

    Directory of Open Access Journals (Sweden)

    Jose M. Inoriza

    2017-03-01

    Conclusiones: Los resultados obtenidos no difieren de otros estudios equiparables. El perfil es de un paciente anciano y pluripatológico que tiene todavía limitaciones tecnológicas. Para superar estas barreras se debería dedicar más tiempo a la formación y a la resolución de problemas tecnológicos.

  16. Outcome of sporadic amyotrophic lateral sclerosis treated With non-invasive ventilation and riluzole Sobrevida en pacientes con esclerosis lateral amiotrófica esporádica tratados con ventilación no invasiva y riluzole

    OpenAIRE

    Martín Sívori; Gabriel E. Rodríguez; Daniel Pascansky; César Séenz; Roberto E. P. Sica

    2007-01-01

    Sporadic amyotrophic lateral sclerosis (sALS) is a progressive degenerative motor neuron disorder lacking specific treatment. Riluzole is the only drug able to modestly slow down the course of the disease. Respiratory insufficiency is the main cause of death; non invasive ventilation (NIV) has shown to improve survival. Our aim was to evaluate the effect of NIV and riluzole on survival. Ninety seven patients with a diagnosis of sALS were assessed and followed up for 60 months. Twenty nine pat...

  17. Three-dimensional verification of prostate cancer patients treated with VMAT by Matrixx detector and COMPASS software IBA; Verificacion tridimensional de pacientes con cancer de prostata tratados con VMAT mediante el detector Matrixx y software COMPASS de IBA

    Energy Technology Data Exchange (ETDEWEB)

    Mateos, J. C.; Luis, F. J.; Cabrera, P.; Carrasco, M.; Sanchez, G.; Herrador, M.

    2011-07-01

    Described in this paper the verification of prostate cancer patients treated with VMAT planned in our hospital, with a prescribed dose of 76 Gy. The ability to simultaneously analyze the patient by any plane COMPASS software (IBA, Germany), together with the detector array Matrixx-Evolution, this system gives a particularly interesting feature. The aim of this paper is to describe the operation of this equipment and validated for patient dosimetry in IMRT and VMAT treatments.

  18. Algunas variables clínicas y de laboratorio en pacientes adultos con leucemia mieloide crónica tratados con interferón alfa recombinante + citosina arabinósido

    OpenAIRE

    Espinosa Martínez, Edgardo; Díaz Durán, Carmen Virginia; Ávila Cabrera, Onel; Hernández Padrón, Carlos; Rodríguez, Luis Ramón; Izquierdo Cano, Lisset; Amor Vigil, Ana María; Lavaut Sánchez, Kalia; Espinosa Estrada, Edgardo; Wade Mateo, Maura; Estrada del Cueto, Marianela

    2011-01-01

    La leucemia mieloide crónica del adulto es la hemopatía maligna más frecuente dentro de los síndromes mieloproliferativos. En un estudio retrospectivo longitudinal realizado entre enero de 1985 y diciembre de 2009, se evaluaron 46 pacientes en fase crónica atendidos en el Instituto de Hematología e Inmunología. Todos recibieron tratamiento inicial citorreductor y posteriormente interferón ? recombinante (INF?r) + citosina arabinósido. El 41,0 % de los enfermos presentó un índice pronóstico de...

  19. Talleres lúdico-pedagógicos con adolescentes: una herramienta para la promoción de la salud

    Directory of Open Access Journals (Sweden)

    Dharah Puck Cordeiro Ferreira

    2016-11-01

    Full Text Available Relatar el intercambio de experiencias entre los adolescentes acerca de los temas tratados en los talleres. Se llevaron a cabo talleres lúdico-pedagógicos con adolescentes en una Unidad de Salud de la Familia en el periodo abril-junio de 2013, en el municipio de Garanhuns/PE, con la base conceptual de intervención psicosocial, ya que esto puede permitir la reflexión de los adolescentes sobre sus diversas experiencias. El sujeto expresa su subjetividad de manera diferente en cada etapa de su vida y contexto en que se insertan. Se producen, en la adolescencia, numerosos factores tales como la sexualidad, la entrada en la edad adulta, la violencia, el uso/abuso de alcohol y otras drogas, entre otros, que deben ser trabajados por los profesionales de la salud desde una perspectiva que tenga en cuenta la singularidad de cada sujeto, integralidad y articulaciones intersectoriales.

  20. Hepatocellular carcinoma: computed tomography assessment after invasive treatment;Hepatocarcinoma: Evaluacion con tomografia computada luego del tratamiento intervencionista

    Energy Technology Data Exchange (ETDEWEB)

    Kozima, Shigeru; Larranaga, Nebil; Wulfson, Gabriela [Servicio de Diagnostico por Imagenes Hospital General de Agudos ' Cosme Argerich' , CABA, Buenos Aires (Argentina); Departamento de Imagenes, CEMIC, Buenos Aires (Argentina); Eisele, Guillermo [Departamento de Imagenes, CEMIC, Buenos Aires (Argentina); Ridruejo, Ezequiel; Mando, Oscar [Seccion de Hepatologia. Departamento de Medicina, CEMIC, Buenos Aires (Argentina); Perazzo, Florencia [Seccion Oncologia. Departamento de Medicina, CEMIC, Buenos Aires (Argentina)

    2008-07-01

    diagnostico de hepatocarcinoma; todas fueron tratadas en forma minimamente invasiva. Para el tratamiento se dividio a los pacientes en dos grupos siguiendo el criterio de Milan. El primer grupo, constituido por 75 pacientes con 109 nodulos, fue tratado con quimioembolizacion. El segundo grupo, de 15 pacientes y 25 nodulos, fue tratado con ablacion por radiofrecuencia. Dentro de nuestra poblacion, hubo un subgrupo de 10 pacientes (14 nodulos) que se trato con ambos metodos. Resultados: De los 90 pacientes tratados, luego de los controles con TC realizados a un mes, 3 meses y cada 3 meses durante dos anios, en 63 casos (70%) se observo acumulacion homogenea del lipiodol, defecto parcial sin realce o ausencia de realce en la lesion tratada. A estos no se les realizo nuevo procedimiento luego del tratamiento inicial. En los 27 pacientes restantes (30%), se practico un nuevo tratamiento por visualizarse defecto parcial o ausencia del lipiodol con realce o realce periferico en la fase arterial de la lesion tratada. En este ultimo grupo, 16 pacientes tratados (17,7%) tuvieron nuevo realce nodular en el parenquima hepatico restante. Conclusion: La TC en las fases sin contraste y arterial, a un mes y cada 3 meses, permite evaluar la efectividad, enfermedad residual y/o la recaida del hepatocarcinoma luego del tratamiento minimamente invasivo. (autores)

  1. competencia con China

    Directory of Open Access Journals (Sweden)

    Elena de la Paz Hernández Águila

    2007-01-01

    Full Text Available El artículo ofrece un diagnóstico del desempeño de la industria mexicana del calzado desde la década de los ochenta hasta la actualidad. Analiza la problemática que ha enfrentado esta rama industrial a partir del proceso de apertura comercial y de la competencia en su mercado interno con productos provenientes de países asiáticos, particularmente China. Problematiza al respecto los retos y las perspectivas que a mediano plazo enfrentará este sector empresarial y sobre las posibilidades de competir en el mercado globalizado.

  2. Construir con Madera

    OpenAIRE

    Olabe-Velasco, F. (Fermín); Val-Hernández, Y. (Yolanda); Varela-de-la-Cruz, P. (Perla); Cabrero-Ballarín, J.M. (José Manuel)

    2010-01-01

    Guía divulgativa ‘Construir con madera’, elaborada por la Cátedra Madera de la Universidad de Navarra y el Gobierno de Navarra. La publicación pretende explicar de forma sencilla los beneficios y posibilidades de este material en la construcción, tanto en lo que respecta a su resistencia, comportamiento frente al fuego, durabilidad, capacidad de aislamiento, propiedades acústicas, estética, respeto al medio ambiente y sostenibilidad como fuente de energía. A modo de ejemplo, en la ...

  3. Aprendiendo química con el tratamiento culinario de frutas, hortalizas y verduras

    Directory of Open Access Journals (Sweden)

    Sánchez Guadix, Mª.A.

    2007-09-01

    Full Text Available La necesidad de acercar la ciencia a la realidad cotidiana del alumnado obliga a buscar nuevos recursos que tradicionalmente no eran tratados en la enseñanza formal: la química presente en la cocina y desarrollada a través de los trucos que han funcionadoen los tratamientos culinarios. En el presente artículo encontramos una reflexión acerca de la urgencia alfabetizar científicamente y de introducir saberes considerados femeninos en las aulas, una estrategia de búsqueda de recursos: la interpretacióncientífica y las aplicaciones didácticas de distintos trucos de cocina relacionados con frutas, hortalizas y verduras, y por último, algunas sugerencias para llevar a cabo distintas actividades en el aula de secundaria.

  4. Leucócitos totais em cães com gastroenterite hemorrágica tratados por autohemoterapia

    Directory of Open Access Journals (Sweden)

    Rallyson Ramon Fernando Barbosa Lopes

    2017-05-01

    Full Text Available A gastroenterite hemorrágica (GEH é comum em cães jovens com sinais clínicos característicos como vômitos e diarreia. Entre as principais causas desse tipo de enfermidade estão as viroses como parvovirose e cinomose. O tratamento de GEH geralmente é sintomático com índice de recuperação em torno de 70%. A autohemoterapia é uma técnica em que se utiliza a administração de sangue autólogo por via intramuscular, a fim de estimular o sistema imunológico. Com o objetivo de avaliar a resposta leucocitária em cães acometidos de GEH e tratados com auto-hemoterapia foram utilizados 23 cães, divididos em dois grupos. No primeiro grupo (11 animais, foi realizada esta técnica em associação com o tratamento sintomático. No segundo grupo (12 animais, foi feito apenas o tratamento sintomático. Os animais foram avaliados por meio de hemograma e taxa de sobrevivência. Concluiu-se que a auto-hemoterapia não influenciou na recuperação dos animais. No entanto, produziu intensa leucocitose, efeito que pode ser investigado com maior amostragem de animais e em situações diversas.

  5. Los tratados y el jardín renacentista en Italia. Principios, metodologías y técnicas

    OpenAIRE

    Taffuri, Tullio

    2014-01-01

    La tesis destaca la influencia que ejerció la teoría, las técnicas y la metodología de proyecto de los principales tratados de la época renacentista en la concepción, diseño y realización de algunos de los más importantes jardines de la época. Los tratados de Vitruvio, Alberti, Filarete, Di Giorgio, Serlio, Palladio, Colonna y Del Riccio establecen una nueva estética y una nueva visión del mundo, basadas en la geometría elemental y en los números simples. En la Grecia antigua, Platón y Pitágo...

  6. Entrevista con Giovanni Levi

    Directory of Open Access Journals (Sweden)

    Monica Oliveira

    2017-06-01

    Full Text Available En esta entrevista, Giovanni Levi - como un conocedor del tema de Familia - realiza una importante evaluación sobre el actual estado de las investigaciones realizadas en el Brasil y em el exterior. Con estilo franco, agudo y lucido critica las visiones tradicionales y sus ilusiones ypropone nuevos conceptos y métodos. La historia de la familia debería ceder espacio para el estudio de las redes relacionales o de los mundos relacionales. De la misma forma, la historia cuantitativa debería abrir espacio para el estudio de las cualidades. Ya con relación a la historia de las elites, tan estudiada y reproducida en una diversidad de trabajos, que deberíase mirar en otra perspectiva. Es decir, no mirar a las reglas sociales predeterminadas, sino a los desvíos y a las variaciones. Levi defiende que los historiadores deben trascender a los documentos que se encuentran fácilmente y que pueden fortalecer perspectivas deformadas y esequilibradas de la sociedad. Para él, los historiadores deben esforzarse por estudiar a aquellos grupos que dejaron pocos rastros documentales. En ese esfuerzo existiría una nueva mirada sobre la historia de la familia.

  7. Entrevista con Patricia Ariza

    Directory of Open Access Journals (Sweden)

    Esperanza Londoño La Rotta

    2017-01-01

    Full Text Available Pensamiento, Palabra y Obra entrevista a una artista, feminista y activista política, quien como mujer y artista ha permitido pensar el arte más allá de un simple espectáculo. Toda una vida dedicada al teatro y a darle voz, a través de sus obras, a víctimas del conflicto colombiano, defensora de derechos humanos; además de hacer evidente en su vida y a través de la plataforma “Artistas por la paz”, las múltiples relaciones que se pueden establecer entre el arte, la construcción de paz y la resolución de conflictos. Hablamos en su casa, en medio del calor de la bienvenida con Patricia Ariza, directora del festival alternativo de teatro, de Mujeres en Escena y de la Corporación Colombiana de Teatro, entre otras muchas actividades que voluntariamente su espíritu libertario ha asumido. Esta entrevista se realizó antes del 2 de octubre, pero con la revisión de los acuerdos que propició el plebiscito ganado por una ínfima minoría por el no, sigue siendo vigente este planteamiento.

  8. Valor nutritivo y utilización para producción de leche del bagazo de alfalfa ensilado con diferentes aditivos

    OpenAIRE

    Gonzalez, V.; Fernández, E.; González, G.; Remón, J.

    2011-01-01

    Mediante pruebas de ingestión, digestibilidad de la materia orgánica (DMO) y lactación se ha estudiado el valor nutritivo del bagazo de alfalfa ensilado sin aditivos (BST), tratado con ácido fórmico (BF) y con formaldehído-sulfúrico (BFS). En la prueba de lactación el bagazo de alfalfa se comparó con heno de alfalfa de calidad media.La ingestión de MO en corderos fue mayor para los bagazos BFS y BF, un 16,4 y 9,3 % respectivamente, que la de BST. La DMO fue 54,4; 60,7 y 61,8 % para BST, BF y ...

  9. Tratamiento con caspofungina de endocarditis por Candida tropicalis resistente a fluconazol Treatment with caspofungin of Candida tropicalis endocarditis resistant to fluconazol

    Directory of Open Access Journals (Sweden)

    Marcelo del Castillo

    2004-04-01

    Full Text Available Las endocarditis causadas por hongos, (Candida en particular, requieren tratamiento médico-quirúrgico, siendo la anfotericina B la droga de elección. Caspofungina es una equinocandina con gran actividad sobre Candida y Aspergillus. Se presenta un paciente con una endocarditis por Candida tropicalis resistente a fluconazol tratado con caspofungina bajo un esquema de salvataje, luego de haber presentado efectos adversos por anfotericina B. El paciente tuvo respuesta microbiológica.Fungal endocarditis, in particular due to Candida species, requires medical and surgical treatment and amphotericin B is the drug of choice. Caspofungin is an echinocandin very effective against Candida and Aspergillus. We present a patient with Candida tropicalis endocarditis, fluconazol resistant, treated with caspofungin, on a compassional basis as a result of adverse effects with amphotericin B. The patient had a microbiological response.

  10. Extracts of Azadirachta indica and Melia azedarach seeds inhibit folliculogenesis in albino rats

    Directory of Open Access Journals (Sweden)

    J.K. Roop

    2005-06-01

    Full Text Available The seed oil of Azadirachta indica A. Juss (neem is used in traditional medicine for its antidiabetic, spermicidal, antifertility, antibacterial, and wound healing properties. The present study was undertaken to investigate the quantitative aspects of follicular development in cyclic female albino rats (135 ± 10 g; 8 groups with 6 animals in each group after oral administration of polar (PF and non-polar (NPF fractions of A. indica seed extract at 3 and 6 mg kg body weight-1 day-1 and Melia azedarach Linn. (dharek seed extract at 24 mg kg body weight-1 day-1 for 18 days. The extracts were prepared using a flash evaporator at 35°C and then dissolved in olive oil to prepare doses on a per kg body weight basis. There was a significant reduction (P = 0.05 in the number of normal single layered follicles (A. indica: 0.67 ± 0.33 and 4.67 ± 2.03 after 3 and 6 mg/kg NPF, and 3.33 ± 1.67 and 1.00 ± 1.00 after 3 and 6 mg/kg PF vs control: 72.67 ± 9.14 and M. azedarach: 0.60 ± 0.40 and 1.80 ± 1.2 after 24 mg/kg PF and NPF, respectively, vs control: 73.40 ± 7.02 and follicles in various stages (I-VII of follicular development in all treatment groups. These extracts also significantly reduced (P = 0.05 the total number of normal follicles in the neem (14.67 ± 5.93 and 1.00 ± 1.00 after 3 and 6 mg/kg PF and 3.67 ± 0.88 and 5.33 ± 2.03 after 3 and 6 mg/kg NPF and dharek (13.00 ± 3.58 and 14.60 ± 2.25 after 24 mg/kg NPF and PF treatments compared to control (216.00 ± 15.72 and 222.20 ± 19.52, respectively. Currently, indiscriminate use of persistent and toxic rodenticides to control rodent populations has created serious problems such as resistance and environmental contamination. Therefore, it becomes necessary to use ecologically safe and biologically active botanical substances that are metabolized and are not passed on to the next trophic level, and that interfere with the reproductive potential particularly growth and differentiation of

  11. Realización y corrección automática de exámenes con hoja de cálculo

    Directory of Open Access Journals (Sweden)

    Sánchez García, Juan Francisco

    2007-01-01

    Full Text Available La forma habitual de realizar exámenes de tipo test es mediante formularios en papel que posteriormente son tratados con un escáner y un software específico que facilita la corrección así como la emisión de informes y la exportación de datos a aplicaciones de hoja de cálculo. En las asignaturas de informática de gestión llama la atención que en algunos casos se hace evaluación de términos informáticos y utilización de aplicaciones informáticas sobre papel, cuando el hacerlo directamente sobre el ordenador permitiría además comprobar los conocimientos prácticos del alumno.Con la idea de facilitar al alumno la cumplimentación de este tipo de exámenes hemos desarrollado una metodología propia utilizando la hoja de cálculo Microsoft Excel. De esta forma el formulario de examen se sustituye por un fichero de hoja de cálculo que posteriormente será tratado para obtener los resultados contenido en el mismo y facilitar su corrección, la cual también se efectuará con la propia hoja de cálculo, utilizando programación en Visual Basic para Aplicaciones (VBA.

  12. The analgesic effect of different antidepressants combined with aspirin on thermally induced pain in Albino mice

    Directory of Open Access Journals (Sweden)

    Abdalla S. Elhwuegi

    2012-04-01

    Full Text Available Background:Combination analgesics provide more effective pain relief for a broader spectrum of pain. This research examines the possible potentiation of the analgesic effect of different classes of antidepressants when combined with aspirin in thermal model of pain using Albino mice.Methods:Different groups of six animals each were injected intraperitoneally by different doses of aspirin (50, 100, or 200 mg/kg, imipramine (2.5, 7.5, 15 or 30 mg/kg, fluoxetine (1.25, 2.5, 5 or 7.5 mg/kg, mirtazapine (1.25, 2.5, or 5 mg/kg and a combination of a fixed dose of aspirin (100 mg/kg with the different doses of the three antidepressants. One hour later the analgesic effect of these treatments were evaluated against thermally induced pain. All data were subjected to statistical analysis using unpaired Student's t-test.Results:Aspirin had no analgesic effect in thermally induced pain. The three selected antidepressants produced dose dependent analgesia. The addition of a fixed dose of aspirin to imipramine significantly increased the reaction time (RT of the lowest dose (by 23% and the highest dose (by 20%. The addition of the fixed dose of aspirin to fluoxetine significantly increased RT by 13% of the dose 2.5 mg/Kg. Finally, the addition of the fixed dose of aspirin significantly potentiated the antinociceptive effect of the different doses of mirtazapine (RT was increased by 24, 54 and 38% respectively.Conclusion:Combination of aspirin with an antidepressant might produce better analgesia, increasing the efficacy of pain management and reduces side effects by using smaller doses of each drug.

  13. Effectiveness of grape seed extract on gamma radiation-induced hazards in albino rats

    International Nuclear Information System (INIS)

    Abd El Azime, A.S.

    2008-01-01

    The present study was designed to determine the possible protective effect of grape seed extract (GSE), rich in proanthocyanidins against gamma radiation-induced oxidative stress associated to serum metabolic disorders in the liver, heart and pancreas tissues of rats. Male albino rats received GSE (100 mg/day/Kg body weight), by gavages, for 14 successive days before whole body exposure to 5 Gy gamma radiation (shot dose). Animals were sacrificed 1, 14, and 28 days post radiation exposure. The results showed that in the irradiated group, tissues superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activities were decreased significantly, while thiobarbituric acid reactive substances (TBARS) content was increased, which was in parallel with significant increases in the activity of serum lactate dehydrogenase (LDH), creatine phosphokinase (CPK), aspartate and alanine aminotransferase (AST and ALT). Hyperglycemia, hyperinsulinaemia, hyperlipidaemia, decreases in red blood cells count (RBCs) count and hemoglobin (Hb) content were also observed in irradiated rats. n the GSE-treated irradiated group, significant increases of SOD, CAT, and GSH-Px activities with significant reduction of TBARS levels were observed in cardiac, liver, and pancreas tissues, in parallel to significant decreases in the activity of serum LDH, CPK, AST, and ALT compared with their corresponding values in the irradiated group. Moreover, serum glucose and insulin contents, RBCs count and Hb content were significantly improved in the GSE-treated irradiated rats. Furthermore, the marked increase in serum triglycerides and total cholesterol observed in irradiated rats, along with elevated LDL-C and decreased HDL-C levels were significantly improved in GSE treated rats. In conclusion, the present data demonstrate that GSE through its free radical scavenging and antioxidant properties attenuates ionizing radiation-induced oxidative injury suggesting that it may be a potential

  14. Pathogenesis of a Chinese strain of bovine adenovirus type 3 infection in albino guinea pigs.

    Science.gov (United States)

    Shi, Hong-Fei; Zhu, Yuan-Mao; Yan, Hao; Ma, Lei; Wang, Xue-Zhi; Xue, Fei

    2014-12-01

    Bovine adenovirus type 3 (BAV-3) is considered one of the most important respiratory tract agents of cattle and is widespread among cattle around the world. A BAV-3 strain was isolated from a bovine nasal swab for the first time in China in 2009 and named HLJ0955. Subsequently, BAV-3 has frequently been isolated from calves with respiratory diseases in China. To date, only limited study on the pathogenesis of BAV-3 infection in cotton rats has been conducted, and the pathogenesis of BAV-3 infection in guinea pigs has not been reported. Therefore, sixteen albino guinea pigs were inoculated intranasally with HLJ0955. All of the infected guinea pigs had apparently elevated rectal temperatures (39.2 °C-39.9 °C) at 2-7 days post-inoculation (PI). Consolidation and petechial hemorrhage were also observed in guinea pigs experimentally infected with HLJ0955. Viral replication was detectable by virus isolation and titration and by immunohistochemistry in the lungs of guinea pigs as early as 24 h PI. Viral DNA was detectable in the lungs of infected guinea pigs during 11 days of observation by real-time PCR. Virus-neutralizing antibodies against BAV-3 were detectable from 11 days PI and reached a peak titer at 15 days PI. Histopathological changes mainly occurred in the lungs of infected guinea pigs and were characterized by thickening of alveolar septa, mononuclear cell infiltration, hemorrhage and alveolar epithelial necrosis. These results indicate that HLJ0955 can replicate in the lungs of guinea pigs and cause fever and gross and histological lesions. The guinea pig infection model of BAV-3 would serve as a useful system for monitoring the infection process and pathogenesis of the Chinese BAV-3 strain HLJ0955, as well as immune responses to BAV-3 vaccines.

  15. Possible Outcome of Fenugreek Seeds Powder Administration on the Fertility of Female and Male Albino Rat

    Energy Technology Data Exchange (ETDEWEB)

    Ibrahim, M F; El-Tawill, G.A., E-mail: gkyrillos@hotmail.co [Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo (Egypt)

    2010-07-01

    Fenugreek (Trigonella foenum-graecum) is an annual plant from the family of Papilionaceae-Leguminosae that has been credited with many medicinal properties. The current study aims to evaluate the possible fertility activity of fenugreek seeds powder on female and male albino rats. To achieve the theme, fenugreek seeds powder (200 mg/rat) were daily administered orally to both female and male Wistar rats for 15 and 30 consecutive days, after which the rats were sacrificed for both biochemical and histopathological observations. Fenugreek treatment significantly decreased the serum cholesterol levels in both female and male rats with a marked increase in the ovary and testis cholesterol levels following 30 days of consecutive administration. The circulating serum female hormones showed an initial elevation at the end of 15 days of fenugreek intake followed by a significant drop in the group of rats that continued to receive the daily fenugreek dose for 30 days. These observations were supported by the notable decline in the ovarian weights further validated by their ovarian histological sections revealing remarkable dissolution of some follicles and prominent abundance of inflammatory cells. In the 30 days interval treated males, the serum testosterone hormone concentrations significantly declined and the testis weights were reduced with evident damage to the seminiferous tubules and interstitial tissues as shown by the histopathological picture of testis tissue sections. Accordingly, it can be deduced that fenugreek seeds powder exert a significant antifertility adverse effect on the female and male rats when supplemented at a considerable dose for an extended time interval

  16. Toxicological evaluation of ethanolic extract of Anacyclus pyrethrum in albino wistar rats

    Directory of Open Access Journals (Sweden)

    Kuttan Sujith

    2017-12-01

    Full Text Available Objective: To evaluate the sub chronic toxicity of ethanolic extract of Anacyclus pyrethrum (A. pyrethrum in albino wistar rats. Methods: In sub chronic toxicity study ethanolic extract of A. pyrethrum prepared in 2%v/v tween 80 was administered to rats at the dose of 1 000 mg/kg per day for 90 days by oral gavage. A control group received only 2%v/v tween 80. During study period the rats were observed for changes body weight. At the end of dosing period rats relative organ weight of the liver, kidney, brain, lungs and spleen in rats treated with A. pyrethrum extract and control group were examined and also rats were subjected to haematological, biochemical and histopathological examination. Results: The administration of ethanolic extract of A. pyrethrum had no effect on body weight, growth and survival. There was no significant difference in the relative organ weight of the liver, kidney, brain, lungs and spleen in rats treated with A. pyrethrum extract and control group. In the present study, all the haematological and biochemical parameters at the end of dosing and observation period did not reveal difference between drug treated and control groups. Studies on histopathological examination of vital organs showed normal architecture suggesting no evidence of pathological lesions. Conclusions: The studies on sub chronic toxicity reveals that no mortalities or evidence of adverse effects on oral administration of extract. The findngs of the study indicate that ethanolic extract of A. pyrethrum had no treatment related toxicological abnormalities and can be considerd as safe for long-term treatment.

  17. Anti-Alzheimer Properties of Probiotic, Lactobacillus plantarum MTCC 1325 in Alzheimer's Disease induced Albino Rats.

    Science.gov (United States)

    Nimgampalle, Mallikarjuna; Kuna, Yellamma

    2017-08-01

    Alzheimer's disease is a type of dementia, and till now there is no suitable drug available for the complete cure of this disease. Now-a-days Probiotics, Lactobacillus strains play a therapeutic role in cognitive disorders through Gut-Brain Axis communication. The present study was aimed to evaluate the anti-Alzheimer properties of Lactobacillus plantarum MTCC1325 against D-Galactose-induced Alzheimer's disease in albino rats. Healthy rats (48) of wistar strain were divided into four groups viz., Group-I: control rats received saline, Group-II: rats received intraperitoneal injection of D-Galactose (120 mg/kg body weight) throughout experiment, Group-III: initially animals were subjected to D-Galactose injection for six weeks, then followed by simultaneously received both D-Galactose and L. plantarum MTCC1325 (12×10 8 CFU/ml; 10 ml/kg body weight) for 60 days and Group-IV: rats which were orally administered only with Lactobacillus plantarum MTCC1325 for 60 days. During the experimentation, both morphometric and behavioural aspects were studied. Later we have examined histopathological changes and estimated cholinergic levels in selected brain regions of all experimental groups of rats including control on selected days. Morphometric, behavioural changes, ACh levels were significantly decreased and pathological hallmarks such as amyloid plaques and tangles were also observed in AD model group. Treatment of AD-group with L. plantarum MTCC1325 for 60 days, not only ameliorated cognition deficits but also restored ACh and the histopathological features to control group. However, no significant effects have been observed in the group treated with L. plantarum alone. The study revealed that, L. plantarum MTCC1325 might have anti-Alzheimer properties against D-Galactose induced Alzheimer's disease.

  18. Impact of dietary oils and fats on lipid peroxidation in liver and blood of albino rats

    Science.gov (United States)

    Haggag, Mohammad El-Sayed Yassin El-Sayed; Elsanhoty, Rafaat Mohamed; Ramadan, Mohamed Fawzy

    2014-01-01

    Objective To investigate the effects of different dietary fat and oils (differing in their degree of saturation and unsaturation) on lipid peroxidation in liver and blood of rats. Methods The study was conducted on 50 albino rats that were randomly divided into 5 groups of 10 animals. The groups were fed on dietary butter (Group I), margarine (Group II), olive oil (Group III), sunflower oil (Group IV) and corn oil (Group V) for 7 weeks. After 12 h of diet removal, livers were excised and blood was collected to measure malondialdehyde (MDA) levels in the supernatant of liver homogenate and in blood. Blood superoxide dismutase activity (SOD), glutathione peroxidase activity (GPx), serum vitamin E and total antioxidant capacity (TAC) levels were also measured to determine the effects of fats and oils on lipid peroxidation. Results The results indicated that no significant differences were observed in SOD activity, vitamin E and TAC levels between the five groups. However, there was significant decrease of GPx activity in groups IV and V when compared with other groups. The results indicated that feeding corn oil caused significant increases in liver and blood MDA levels as compared with other oils and fats. There were positive correlations between SOD and GPx, vitamin E and TAC as well as between GPx and TAC (r: 0.743; P<0.001) and between blood MDA and liver MDA (r: 0.897; P<0.001). The results showed also negative correlations between blood MDA on one hand and SOD, GPx, vitamin E and TAC on the other hand. Conclusions The results demonstrated that feeding oils rich in polyunsaturated fatty acids (PUFA) increases lipid peroxidation significantly and may raise the susceptibility of tissues to free radical oxidative damage. PMID:24144131

  19. Calcium, zinc and vitamin E ameliorate cadmium-induced renal oxidative damage in albino Wistar rats

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    Pradeepkiran Jangampalli Adi

    Full Text Available This study was aimed to examine the protective effects of supplementation with calcium + zinc (Ca + Zn or vitamin E (Vit-E on Cd-induced renal oxidative damage. Young albino Wistar rats (180 ± 10 g (n = 6 control rats, Cd, Cd + Ca + Zn, and Cd + Vit-E experimental groups and the experimental period was 30 days. Rats were exposed to Cd (20 mg/kg body weight alone treated as Cd treated group and the absence or presence of Ca + Zn (2 mg/kg each or Vit-E (20 mg/kg body weight supplementation treated as two separate groups. The activities of the stress marker enzymes superoxide dismutase (SOD, catalase (CAT, glutathione reductase (GR, glutathione peroxidase (GPx, glutathione-S-transferase (GST and lipid peroxidase (LPx were determined in renal mitochondrial fractions of experimental rats. We observed quantitative changes in SOD isoenzymatic patterns by non-denaturing PAGE analysis, and quantified band densities. These results showed that Cd exposure leads to decreases in SOD, CAT, GR, and GPx activities and a concomitant increase in LPx and GST activities. Ca + Zn and Vit-E administration with Cd significantly reversed Cd-induced perturbations in oxidative stress marker enzymes. However, Vit-E showed more inhibitory activity against Cd than did Ca + Zn, and it protected against Cd-induced nephrotoxicity. Keywords: Cadmium (Cd, Oxidative stress, Lipid peroxidation, Nephrotoxicity, PAGE analysis

  20. Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats

    Directory of Open Access Journals (Sweden)

    Sajad Hamid

    2012-02-01

    Full Text Available Fluorides have been a cause of concern for scientists and environmentalists for the long because of their harmful effects on the human and animal life but the problem was highlighted during the twentieth century because of great increase in the human population and industrialization. Since fluorides accumulate in calcified and hard tissues of the body such as bone and teeth and can be detected easily in these tissues, so most of the previous studies focused on the effects of fluorides on these tissues. However, during the past decade researchers all over the world have felt that there is a need to study the effects of fluorides on various other tissues of the body including CNS as fluoride intake for prolonged period is known to cause abnormal behavioural pattern, grave implications for Alzheimer’s Disease, Dementia, Attention deficit disorder and reduced I.Q in children as the fluorides are known to cross blood brain barrier. Hence the present study has thrown light on the involvement of brain in chronic fluoride toxicity. The target organ of studied was cerebrum. In the Study, albino rats were exposed to 30 or 100 ppm fluoride (asNaF in drinking water for 3 months. Rats exposed to 30 ppm fluoride did not show any notable alterations in brain histology, whereas rats exposed to 100 ppm fluoride showed significant neurodegenerative changes in lhe motor cortex.Changes included decrease in size and number of neurons in all the regions, signs of chromatolysis and gliosis in the motor cortex. These histological changes suggest a toxic effect of high-fluoride intake & on chronic use. [J Interdiscipl Histopathol 2012; 1(1.000: 30-34