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Sample records for albinos tratados con

  1. Análisis químico del esmalte dental humano tratado con una sustancia remineralizante experimental

    OpenAIRE

    González García, Jennifer

    2015-01-01

    El objetivo de este trabajó fue analizar químicamente el efecto de la aplicación de una sustancia remineralizante experimental (SRM) sobre el esmalte dental humano. Se tomaron 40 molares humanos repartidos aleatoriamente en 4 grupos, cada uno de 10 especímenes. Grupo 1: grupo sin tratamiento, Grupo 2: grupo tratado con peróxido de hidrógeno al 35%, Grupo 3. Grupo tratado con la sustancia remineralizante experimental, Grupo 4: grupo tratado con peróxido de hidrógeno al 35% y después con la sus...

  2. CON EL TRATADO DE LIBRE COMERCIO PERDIMOS TOD@S

    Directory of Open Access Journals (Sweden)

    Mario Rodríguez

    2008-12-01

    Full Text Available Resumen El objetivo principal de este artículo es analizar la inserción de la economía guatemalteca al proceso del desarrollo global del sistema capitalista. El trabajo sustenta la idea de que la estructura productiva se fue configurando a partir de los procesos de ajuste estructural y que la misma tuvo un sesgo marcadamente neoliberal. Esto permitió generar una plataforma política y económica que facilito la imposición de un modelo dependiente con la instauración de un Acuerdo Comercial con Estados Unidos. Este mecanismo es la última fase de la implantación del modelo económico de acumulación, que permite una inserción del capital nacional al gran mercado capitalista mundial y reconfigura la estructura productiva agrícola del país adaptándola a las nuevas necesidades del capital global.   Abstract The Objective of this article is analyzing the insertion of the Guatemalan economy to process of world development of capitalist system. The work support the idea of the productive structure was forming to begin of structures adjustments process and had a slant markedly neoliberal. It allowed produce a politic platform and economic that made easy the imposition of a dependent model with the establishment of one trade agreement with United States. It mechanism is the last stage of the implantation of economic model of accumulation, that allow a insertion of national working capital to big world capitalist market and reforming the farming productive structure of Guatemala; adjustmenting the country to the new necessities of world working capital.

  3. Modificaciones del timo de becerros tratados con clenbuterol para el consumo humano

    OpenAIRE

    Villar Pastor, Carlos Manuel

    2005-01-01

    Se estudian los efectos sobre el timo del P..2-agonistaclenbuterol utilizado ilegalmente como sustancia finalizadora en el engorde del ganado;considerando tanto su administración en solitario como asociado a la dexametasona. Para ello se utilizaron 18 terneros machos, Charolais x Retinto, de 12-14 meses de edad, que se asignan aleatoriamente en tres grupos experimentales: Grupo tratado con Clenbuterol (A, n=6); Grupo con clenbuterol más dexametasona (B, n=6); Grupo Control (n=6). Los efectos ...

  4. Esquistossomose mansoni experimental: carga parasitária e distribuição de vermes adultos no sistema porta de ratos albinos tratados com Azatioprina

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    Carlos Alberto Moreira Campos

    1983-09-01

    Full Text Available Estudou-se o curso da infecção esquistossomótica experimental no rato albino, um hospedeiro singular para o Schistosoma mansoni, e quatro semanas após a infecção houve uma rápida diminuição na carga parasitária, fato esse denominado por alguns pesquisadores como ' fenômeno de autocura Contudo, após a administração de um imunossupressor - a Azatioprina - observou-se uma maior susceptibilidade dos ratos à infecção, com os animais apresentando um significativo retardamento no chamado "fenômeno de autocura A grande maioria dos vermes é recuperada nos vasos intra-hepáticos do sistema porta, sem que haja migração para as veias mesentéricas. Quando os ratos foram tratados com Azatioprina observou-se uma significativa localização mesentérica dos vermes adultos neste hospedeiro.The course of experimental Schistosoma mansoni infection in the albino rat, a singular host for schistosomes was studied. Four weeks after infection there was a decrease of worm burden, a sélf-cure phenomenon reported by other investigators. However, after administration of a immunosupressive drug - Azathioprine - an increase in susceptibility of rats to infection was observed, with the animals presenting a significant delay in the to period selfcure. The majority of worms were recovered from the intra-hepatic veins of the portal system, but there was no migration to mesenteric veins. When rats were treated with Azathioprine a significant mesenteric localization of schistosomes was observed in this host.

  5. Cambios psicológicos en pacientes con espondiloartritis axial tratados con infliximab

    OpenAIRE

    Morlà Novell, Rosa M.

    2015-01-01

    Es conocido que los pacientes con enfermedades reumáticas presentan alteraciones psicológicas relacionadas con su enfermedad articular crónica. Algunos estudios reportan el beneficio de las terapias biológicas en las espondiloartritis (EsP), pero son pocos los datos acerca del impacto de los fármacos biológicos en los síntomas psicológicos. El objetivo del estudio fue el de analizar la influencia del tratamiento con un fármaco biológico anti-TNFα, infliximab (IFX), en los síntomas de ansi...

  6. Esquistossomose mansoni experimental: carga parasitária e distribuição de vermes adultos no sistema porta de ratos albinos tratados com Azatioprina

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Moreira Campos

    1983-09-01

    Full Text Available Estudou-se o curso da infecção esquistossomótica experimental no rato albino, um hospedeiro singular para o Schistosoma mansoni, e quatro semanas após a infecção houve uma rápida diminuição na carga parasitária, fato esse denominado por alguns pesquisadores como ' fenômeno de autocura Contudo, após a administração de um imunossupressor - a Azatioprina - observou-se uma maior susceptibilidade dos ratos à infecção, com os animais apresentando um significativo retardamento no chamado "fenômeno de autocura A grande maioria dos vermes é recuperada nos vasos intra-hepáticos do sistema porta, sem que haja migração para as veias mesentéricas. Quando os ratos foram tratados com Azatioprina observou-se uma significativa localização mesentérica dos vermes adultos neste hospedeiro.

  7. Toxicidad cutánea a corto plazo de pacientes con cáncer de mama tratados con radioterapia hipofraccionada

    OpenAIRE

    Rolando Loría-Ruiz; Rafael Lengua-Reyes; Erick Palacios-García; Adriana Fondevilla-Soler

    2013-01-01

    Antecedentes: reportar la factibilidad y resultados de toxicidad cutánea en una cohorte de pacientes portadores de cáncer de mama, tratados con un esquema de hipofraccionamiento de radioterapia externa, con un manejo multidisciplinario. Métodos: utilizando un software SPSS v18, se realizó un análisis retrospectivo de 299 pacientes (6 H y 293 M), tratados entre marzo de 2009 y diciembre de 2011, en el Instituto Oncológico del Sureste, Murcia, España. La mediana de edad fue de 54 años (rango, 3...

  8. Características de los pacientes tratados con Etanercept de un registro local de terapia biológica

    OpenAIRE

    Rosas, J; Santos-Soler, G.; Senabre, J. M.; Santos-Ramírez, C.; Barber, X.; Sánchez Barrioluengo, Mabel; Salas, E; Llahí, N.; Cano, C.; Riestra, R.

    2011-01-01

    [Objetivos]: Conocer las características de los pacientes en tratamiento con etanercept (ETN), en seguimiento en la Sección de Reumatología del Hospial Marina Baixa. [Material y método]: Estudio prospectivo desde el año 2001, de los pacientes en tratamiento con ETN. Se compararon los resultados con el global de los pacientes tratados con fármacos anti-TNF. Se recogió el diagnóstico de la enfermedad, datos epidemiológicos generales (edad, sexo, nacionalidad), resultado de la prueba de Mantoux ...

  9. Cambios en la vía aérea superior en pacientes adultos tratados con ortodoncia con exodoncias de 4 premolares

    OpenAIRE

    Riera Seguí, María

    2014-01-01

    El objetivo de este estudio fue investigar los cambios que se producen en las dimensiones de la vía aérea superior en pacientes tratados con o sin exodoncias utilizando mínimo y máximo anclaje. Se seleccionaron telerradiografías laterales de cráneo de 24 pacientes con Clase I, con discrepancia óseo-dentaria severa o con biprotrusión, y fueron divididos en tres grupos (cada uno de ellos formado por 3 hombres y 5 mujeres) según el tratamiento recibido: grupo 1- ocho pacientes tra...

  10. Estudio sobre la evolución de la atrofia retiniana en pacientes con coriorretinopatía serosa central tratados con terapia fotodinámica

    OpenAIRE

    Sierra Rodríguez, María Ángeles

    2015-01-01

    Estudio sobre la evolución de la atrofia retiniana en pacientes con coriorretinopatía serosa central tratados con terapia fotodinámica. Quermos demostrar la correlación entre la atrofia retiniana posterior al tratamiento de la coriorretinopatía serosa central (CSC) con terapia fotodinámica (TFD) con verteporfina y los distintos factores asociados: edad del paciente, tiempo transcurrido desde el diagnóstico, dosis de verteporfina empleada, número de sesiones necesarias para la completa reab...

  11. Estudio prospectivo del funcionamiento cognitivo en pacientes de cáncer de colon tratados con quimioterapia

    OpenAIRE

    López Santiago, Sonia

    2011-01-01

    El objetivo de esta tesis es investigar los cambios en rendimiento cognitivo de pacientes de cáncer de colon tratados con quimioterapia adyuvante. El método ha sido el estudio longitudinal unifactorial de tres medidas (T1: antes de la quimioterapia, T2: al finalizar el tratamiento y T3 seis meses después de T2); se explora: memoria verbal, función ejecutiva y habilidad psicomotora y variables moduladoras (ansiedad, depresión, astenia y calidad de vida). Muestra: 77 participantes, 63% varones,...

  12. Estudio del grado de satisfacción en pacientes edéntulos totales tratados con implantes

    OpenAIRE

    Regina Mestre Aspa; Mª Àngels Sánchez Garcés; Leonardo Berini Aytés; Cosme Gay Escoda

    2001-01-01

    El objetivo de este estudio fue evaluar el grado de satisfacción de los pacientes edéntulos totales tratados en nuestro servicio mediante implantes dentales y la colocación posterior de una prótesis implantosoportada (sobre dentadura o prótesis fija). Para evaluar el grado de satisfacción se realizó una encuesta telefónica con seis preguntas: 1) ¿Siente algún tipo de dolor en los implantes? 2) ¿Tiene algún problema cuando habla? 3) ¿Se atreve a reír con esta prótesis? 4) ¿Puede comer cómodame...

  13. Protección frente a la tinción dentaria en dientes tratados con tetraciclinas al aplicar un antioxidante (ácido ascórbico)

    OpenAIRE

    Bermúdez Semprún, María Esther; Beltri Orta, Paola; Bartolomé Villar, Begoña

    2014-01-01

    En la presente investigación pretendemos optimizar los resultados, evitando la coloración coronal, en procedimientos odontológicos donde sea imprescindible el uso de tetraciclinas así como evaluar la disminución de las coloraciones coronales, al aplicar un antioxidante (Acido Ascórbico) en dientes tratados con tetraciclinas (Minociclina y Doxiciclina). En los dientes tratados con minociclina y doxiciclina observamos cambios en la coloración dentaria apreciables tanto en corona como en la raíz...

  14. Toxicidad cutánea a corto plazo de pacientes con cáncer de mama tratados con radioterapia hipofraccionada

    Directory of Open Access Journals (Sweden)

    Rolando Loría-Ruiz

    2013-12-01

    Full Text Available Antecedentes: reportar la factibilidad y resultados de toxicidad cutánea en una cohorte de pacientes portadores de cáncer de mama, tratados con un esquema de hipofraccionamiento de radioterapia externa, con un manejo multidisciplinario. Métodos: utilizando un software SPSS v18, se realizó un análisis retrospectivo de 299 pacientes (6 H y 293 M, tratados entre marzo de 2009 y diciembre de 2011, en el Instituto Oncológico del Sureste, Murcia, España. La mediana de edad fue de 54 años (rango, 31-89; 145 (48,49% pacientes con cáncer de mama derecha y 154 (51,50% de mama izquierda. Con base en la 7ª ed AJCC, la etapificación patológica fue: 118 (39,5% pacientes T1, 114 (38,1% T2, 43 (14,1% T3, 11 (3,8% T4, 5 (1,7% Tis, 4 (1,3% Tx; 137 pacientes (45,8% eran N0, 94 (31,5% N1, 45 (15% N2, 20 (6,70% N3 y 3 (1,00% Nx. Todos los pacientes se sometieron a RTE con técnica 3D conformada con esquema hipofraccionado de 2,67 Gy/día, en 15 fracciones para una dosis total de 40.05 Gy. Se realizó irradiación electiva a la región supraclavicular en 169 pacientes, con igual fraccionamiento. El 100% de la muestra se sometió a cirugía, el 84,3% recibió quimioterapia (66,21% postoperatoria y 18,1% neoadyuvante. Resultados: sesenta y siete pacientes (23,1% presentaron toxicidad cutánea grado 2 al finalizar el tratamiento. No se reportó toxicidad cutánea aguda severa. Conclusión: el esquema de hipofraccionamiento empleado en cáncer de mama es factible y no ha demostrado incremento en la toxicidad aguda severa a nivel de piel.

  15. Aplicación de un antioxidante en dientes tratados con tetraciclinas y/o MTA.

    OpenAIRE

    Bermúdez Semprún, María Esther

    2014-01-01

    Una vez que el diente erupciona en la cavidad bucal, lo hace con una formación radicular incompleta, se denomina diente inmaduro o con ápice abierto. La patología pulpar, como secuela de caries o de lesión traumática puede interferir en la vitalidad pulpar, conllevando a una interrupción de la formación normal de la raíz y como consecuencia, una raíz de paredes delgadas y propensas a la fractura. A partir del 2001 se introdujo la revascularización, que tiene la capacidad de formar tejido ...

  16. Ataque de viento externo con manifestaciones de parálisis facial periférica tratado con acupuntura

    OpenAIRE

    Pinzón Ramírez, Betty Alejandra

    2012-01-01

    El ataque de viento externo es considerado desde la medicina china como un síndrome patológico que puede cursar con manifestaciones de parálisis facial semejante a la parálisis de Bell o parálisis facial idiopática de la medicina occidental, la cual también es efectivamente tratada con acupuntura; sin embargo en la actualidad no hay estudios al respecto en nuestra población. El objetivo es describir las características de población, presentación y evolución de la parálisis facial asociada ...

  17. Análisis de la evolución del queratocono tratado con Crosslinking

    OpenAIRE

    López Izquierdo, Inmaculada

    2014-01-01

    El queratocono es una patología no inflamatoria de la córnea en la que se produce un adelgazamiento corneal, que causa un aumento progresivo de la curvatura de la córnea, con miopía y astigmatismo irregular (defectos ópticos que causan una importante pérdida de visión). Es una enfermedad que evoluciona aumentando progresivamente y llegando en la fase avanzada a un adelgazamiento y una ectasia (deformidad) grave, que explicaría la acusada distorsión de las imágenes y la pérdida de agudeza visu...

  18. Abstinencia espontánea en ratones tratados con Mimosa pudica

    OpenAIRE

    Onel Fong Lores; Clara Azalea Berenguer Rivas; Edgar Puente Zapata; Hilario Salas Martínez

    2014-01-01

    La planta Mimosa pudica (moriviví, como comúnmente se le conoce), ha sido empleada tradicionalmente como anestésico, antidepresivo, sedante, antialopécico, entre otras propiedades farmacológicas; sin embargo, en los últimos años su consumo se ha convertido en excesivo. Con el objetivo de conocer el potencial adictivo de esta planta se desarrolló un ensayo de abstinencia espontánea en ratones de la línea NMRI, llevado a cabo durante 20 días, para lo cual se administró una dosis de 1 000 mg/kg ...

  19. Poblaciones linfocitarias, células dendríticas y perfil de citoquinas en ratones con melanoma tratados con Uncaria tomentosa

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    Iván Lozada-Requena

    2015-10-01

    Full Text Available Objetivos. Evaluar el efecto inmunomodulador sobre poblaciones linfocitarias, células dendríticas (DC, citoquinas Th1/Th2/Th17 (T-helper e inflamatorias en el ámbito sistémico y/o en el microambiente tumoral de ratones con o sin melanoma. Materiales y métodos. Se obtuvieron muestras de sangre periférica y/o de tumores primarios de ratones con melanoma B16 tratados o no con un extracto hidroalcohólico de Uncaria tomentosa (UT con 5,03% de alcaloides oxindólicos pentacíclicos (UT-POA obtenido de la corteza de la planta. Todos los ensayos de medición de células y citoquinas fueron realizados por citometría de flujo. Resultados. UT-POA a nivel sistémico incrementa la relación CD4/CD8a (Cluster of Differenciation, mientras que la activación celular es inversamente proporcional; incrementa la proporción de DCm (DC mieloides; induce un perfil Th1 proinflamatorio y reduce la respuesta Th17. TNF-a (tumor necrosis factor alpha y IL-17A (interleuquina correlacionan positiva y negativamente con la relación CD4/CD8a. Conclusiones. El incremento de Th1 (TNF-a puede tener como consecuencia el incremento de linfocitos CD4 o la activación de macrófagos M1. Aunque UT-POA muestra un incremento de DCm, este no es dosis-dependiente. La disminución de Th17 (IL-17A puede favorecer el funcionamiento de los linfocitos CD8a. UT-POA muestra mejores efectos inmunomoduladores en el ámbito sistémico que intratumoral

  20. Poblaciones linfocitarias, células dendríticas y perfil de citoquinas en ratones con melanoma tratados con Uncaria tomentosa

    Directory of Open Access Journals (Sweden)

    Iván Lozada-Requena

    2015-12-01

    Full Text Available Objetivos. Evaluar el efecto inmunomodulador sobre poblaciones linfocitarias, células dendríticas (DC, citoquinas Th1/Th2/Th17 (T-helper e inflamatorias en el ámbito sistémico y/o en el microambiente tumoral de ratones con o sin melanoma. Materiales y métodos. Se obtuvieron muestras de sangre periférica y/o de tumores primarios de ratones con melanoma B16 tratados o no con un extracto hidroalcohólico de Uncaria tomentosa (UT con 5,03% de alcaloides oxindólicos pentacíclicos (UT-POA obtenido de la corteza de la planta. Todos los ensayos de medición de células y citoquinas fueron realizados por citometría de flujo. Resultados. UT-POA a nivel sistémico incrementa la relación CD4/CD8a (Cluster of Differenciation, mientras que la activación celular es inversamente proporcional; incrementa la proporción de DCm (DC mieloides; induce un perfil Th1 proinflamatorio y reduce la respuesta Th17. TNF-a (tumor necrosis factor alpha y IL-17A (interleuquina correlacionan positiva y negativamente con la relación CD4/CD8a. Conclusiones. El incremento de Th1 (TNF-a puede tener como consecuencia el incremento de linfocitos CD4 o la activación de macrófagos M1. Aunque UT-POA muestra un incremento de DCm, este no es dosis-dependiente. La disminución de Th17 (IL-17A puede favorecer el funcionamiento de los linfocitos CD8a. UT-POA muestra mejores efectos inmunomoduladores en el ámbito sistémico que intratumoral

  1. Caracterización de un suelo arcilloso tratado con hidróxido de calcio

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    Carlos Hernando Higuera Sandoval

    2013-02-01

    Full Text Available Propone unametodología para el tratamiento de suelos susceptibles (arcillas mediante la incorporación del hidróxido de calcio como estabilizante, en busca del mejoramiento de sus características físicas, mecánicas y químicas. La caracterización del suelo consistió en la elaboración de una serie de ensayos de laboratorio que determinaran sus características físico-mecánicas y químicas. Además de esto, se diseñaron mezclas de suelo-hidróxido de calcio en las que se varió el porcentaje de aditivo entre el 2% y el 12%, con el fin de observar las tendencias de sus características y poder así seleccionar el porcentaje óptimo de hidróxido de calcio, que proporcionará mejores condicionesde trabajabilidad del suelo estudiado. Como resultado se obtuvo una mezcla que optimizó el comportamiento del suelo original en cuanto a sus propiedades de plasticidad, resistencia y estabilidad, transformando un suelo pobre en uno adecuado para estructuras de pavimentos.

  2. Caracterización de un suelo arcilloso tratado con hidróxido de calcio

    Directory of Open Access Journals (Sweden)

    Óscar Eduardo Pardo Naranjo

    2012-06-01

    Full Text Available Propone una metodología para el tratamiento de suelos susceptibles (arcillas mediante la incorporación del hidróxido de calcio como estabilizante, en busca del mejoramiento de sus características físicas, mecánicas y químicas. La caracterización del suelo consistió en la elaboración de una serie de ensayos de laboratorio que determinaran sus características físico-mecánicas y químicas. Además de esto, se diseñaron mezclas de suelo-hidróxido de calcio en las que se varió el porcentaje de aditivo entre el 2% y el 12%, con el fin de observar las tendencias de sus características y poder así seleccionar el porcentaje óptimo de hidróxido de calcio, que proporcionará mejores condiciones de trabajabilidad del suelo estudiado. Como resultado se obtuvo una mezcla que optimizó el comportamiento del suelo original en cuanto a sus propiedades de plasticidad, resistencia y estabilidad, transformando un suelo pobre en uno adecuado para estructuras de pavimentos.

  3. Remoción de color de lixiviados tratados biólogicamente mediante oxidación con permanganato de potasio

    OpenAIRE

    Bastidas, Mónica Lorena; Castro Gómez, Julio Andrés

    2004-01-01

    En el presente trabajo se estudió la oxidación química con permanganato de potasio y un oxidante a base de manganato de nombre comercial manhídrox, del lixiviado tratado previamente en un reactor biológico anaerobio de flujo ascendente (UASB) en el Relleno Sanitario La Esmeralda, con el propósito central de remover el color de dichas aguas residuales y observar el efecto en la remoción de turbiedad, DQO y DBO5. Los ensayos realizados mostraron que el permanganato de potasio es más efectivo, c...

  4. Calidad de vida y satisfacción del paciente anciano no oncológico con dolor irruptivo tratado con fentanilo sublingual

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    J. Pérez-Cajaraville

    2016-02-01

    Full Text Available Introducción: La prevalencia del dolor irruptivo (DI es > 55 % en los pacientes no oncológicos y cercana al 70 % en pacientes con dolor crónico. El DI deteriora el estado funcional y emocional de los pacientes, lo cual se traduce en una menor calidad de vida. Se ha descrito que un 50 % de la población oncológica anciana podría padecerlo, pero en ancianos no oncológicos los datos disponibles sobre el tratamiento del DI son limitados. Objetivos: El objetivo primario de este estudio fue valorar la calidad de vida y la satisfacción del paciente anciano no oncológico con DI tratado con fentanilo sublingual. Los objetivos secundarios fueron evaluar el cambio en la intensidad del dolor, el número de episodios de DI y el tiempo de respuesta al tratamiento con fentanilo sublingual, y describir su perfil de seguridad. Material y métodos: Estudio retrospectivo multicéntrico realizado en 78 pacientes con un periodo de recogida de datos de un mes. Se eligió a pacientes > 70 años, con DI (EVA ≥ 6 y tratamiento de base con opioides, a los cuales se les hubiera prescrito citrato de fentanilo sublingual para el tratamiento del DI. Se incluyeron datos basales (control 0 y de las visitas/controles telefónicos a los 3, 15 y 30 días (controles 1, 2 y 3, respectivamente. Resultados: Al inicio del estudio, el valor medio de EVA fue de 7,52 (DE 0,90 y la afectación media en las actividades cotidianas en el cuestionario CBD fue de 6,7/10 (DE 1,21. Al finalizar el estudio los pacientes tuvieron una afectación de 4,36/10 en sus actividades diarias a causa del dolor (p < 0,0001. El promedio de los ítems de intensidad del dolor (CBD se redujo 2,38 puntos vs. basal (p < 0,0001. La puntuación media en las dimensiones de salud física y salud mental del cuestionario SF-12 subió 2,46 y 9,27 puntos, respectivamente, vs. basal, de forma significativa (p = 0,0051 y p < 0,0001, respectivamente. El 75,32 % de los pacientes y el 92,21 % de los investigadores

  5. Estado de salud bucodental de los pacientes con linfoma que van a ser tratados en la Región de Murcia

    OpenAIRE

    Gallego Martínez, Juan

    2016-01-01

    Objetivos: Establecer el estado de salud oral de los pacientes que van a ser tratados por un linfoma; mediante un estudio descriptivo y analítico de la prevalencia de caries, xerostomía, estado periodontal, higiene oral y otras patologías bucodentarias, en este grupo de población. Estudiar la posible existencia de asociaciones o relaciones entre las distintas variables; y comparar estos resultados con los obtenidos por otros autores, mediante la revisión de la literatura. Averiguar las necesi...

  6. Evolución clínica de pacientes tratados con factor de transferencia Clinical evolution of patients treated with transfer factor

    OpenAIRE

    María Aida Cruz Barrios; Blanca Nieves Rodríguez Montiel; Juan Antonio Furones Mourelle; Elisa Pérez Barrera; Alberto C Morris Abella; Santos Huete Ferreira

    2004-01-01

    La efectividad del factor de transferencia no ha sido evaluada en investigaciones poscomercialización. Realizamos un estudio transversal y descriptivo en 9 hospitales de Ciudad de La Habana, desde abril del 2001 hasta abril del 2002, para evaluar la evolución clínica de 280 pacientes tratados con este inmunoestimulante. Se midió el número de recurrencias de la enfermedad presentadas un año antes y las observadas un año después del tratamiento. Además, se obtuvo información sobre esquema terap...

  7. Comportamiento detersivo de las formulaciones ecológicas en la extracción de grasas y proteínas en tejido de algodón aprestado y tratado con diversos suavizantes

    OpenAIRE

    Carrión Fité, Francisco Javier; Serra Gasol, Miquel

    2002-01-01

    En el presente trabajo se efectuó un estudio del comportamiento detersivo producido por una formulación ecológica, aplicada para el lavado de un tejido de algodón aprestado con una resina DMDHEU y tratado con diferentes suavizantes catiónicos, del tipo de amonio silicona y esterquat. A estos tejidos se aplicaron, antes del lavado, dos impurezas del tipo proteína y una tipo aceitosa. Los efectos del detergente, en la extracción de tales impurezas del tejido aprestado y tratado con los diferent...

  8. Función adrenal y metabolismo lipídico en niños asmáticos tratados con budesonida

    OpenAIRE

    Paoli-de Valeri Mariela; Zerpa-de Miliani Yajaira; Valeri-Dávila Ezio G.; Bellabarba Gabriela

    1999-01-01

    Objetivo. Evaluar el efecto de bajas dosis de budesonida inhalado sobre la función adrenal y el metabolismo lipídico en niños asmáticos. Material y métodos. Se estudiaron: 10 niños asmáticos (edad promedio, 8.6 años) tratados con budesonida inhalado (200-300 µg/día) por un lapso mayor a tres meses (grupo A); 15 niños asmáticos (edad promedio, 7.8 años) sin tratamiento esteroideo (grupo B), y 10 niños no asmáticos (grupo C). Se determinaron los niveles de cortisol basal y postestímulo con ACTH...

  9. Avaliação de parâmetros antioxidantes em ratos tratados com sevoflurano Evaluación de parámetros antioxidantes en ratones tratados con sevoflurano Evaluation of antioxidant parameters in eats treated with sevoflurane

    Directory of Open Access Journals (Sweden)

    Francisco J. L Bezerra

    2010-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O sevoflurano é um éter halogenado com flúor que sofre biotransformação hepática através do citocromo P450 2E1. Éteres halogenados que sofrem biotransformação pelo P450 2E1 podem produzir espécies reativas do oxigênio (ERO e promover enfraquecimento do sistema de defesa antioxidante. O objetivo deste trabalho foi investigar a relação entre a atividade das enzimas antioxidantes eritrocitárias e o sevoflurano. MÉTODO: Os animais foram distribuídos em quatro grupos: Grupo 1 controle: apenas oxigênio a 100% (1 L.min-1 por 60 minutos durante 5 dias consecutivos; Grupo 2 - sevoflurane 4,0% em oxigênio a 100% (1 L.min-1 por 60 minutos durante 5 dias consecutivos; Grupo 3 - isoniazida (i.p., 50 mg.kg-1 de peso corporal /dia, durante 4 dias e em seguida tratados apenas com oxigênio a 100% (1 L.min-1 por 60 minutos durante 5 dias consecutivos; Grupo 4 - isoniazida por via intraperitoneal na dose de 50 mg.kg-1 de peso corporal, diariamente durante 4 dias, seguido da administração do sevoflurane a 4,0% em oxigênio a 100% (1 L.min-1 por 60 minutos durante 5 dias. Após 12 horas da última exposição ao sevoflurane, os animais foram sacrificados e o sangue foi coletado através da veia porta para análise da atividade das enzimas antioxidantes. RESULTADOS: Aumento da atividade específica da glicose-6-fosfato desidrogenase, diminuição da atividade específica da catalase, principalmente no grupo de animais pré-tratados com isoniazida e, em seguida, tratados com sevoflurano. A glutationa peroxidase não apresentou alteração na sua atividade. CONCLUSÕES: A interação do sevoflurano com indutores enzimáticos do citocromo P450 2E1 pode propiciar a instalação do estresse oxidativo caso a exposição se torne prolongada e repetitiva.JUSTIFICATIVA Y OBJETIVOS: El sevoflurano es un éter halogenado con flúor que sufre una biotransformación hepática a través del citocromo P450 2E1. Los

  10. PACIENTES DIABÉTICOS CON ENFERMEDAD CORONARIA MULTIVASO, TRATADOS MEDIANTE INTERVENCIONISMO CORONARIO PERCUTÁNEO / Diabetic patients with multivessel coronary disease treated by percutaneous coronary intervention

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    Suilbert Rodríguez Blanco

    2013-10-01

    Full Text Available Resumen Introducción: La enfermedad coronaria es la principal causa de morbilidad y mortalidad en los pacientes diabéticos. Muchos estudios han comparado el tratamiento médico más intervencionismo percutáneo con tratamiento médico más cirugía, en pacientes diabéticos con enfermedad de múltiples vasos. La cirugía de revascularización continúa siendo el tratamiento de elección. Objetivo: Caracterizar los pacientes diabéticos con enfermedad coronaria multivaso, tratados mediante intervencionismo coronario percutáneo. Método: Estudio observacional, descriptivo y transversal en 57 pacientes diabéticos con enfermedad de múltiples vasos, tratados mediante intervencionismo coronario percutáneo en el Laboratorio de Hemodinámica del Hospital "Hermanos Ameijeiras", entre enero de 2010 y julio de 2011. Resultados: Predominaron el sexo masculino (66,66 % y el grupo entre 50-64 años (36,85 %. El factor de riesgo cardiovascular más identificado fue la hipertensión arterial (54,38 %, seguido de la dislipidemia (49,12 %. En el grupo de edad más representado predominó la dislipidemia y el hábito de fumar. El diagnóstico más observado fue la angina de esfuerzo estable (45 pacientes, 78,95 %. El tipo de stent más utilizado fue el liberador de fármaco (54,39 % y la arteria más revascularizada fue la descendente anterior (36 pacientes, 63,15 %. Conclusiones: Se encontró una relación entre los pacientes sin éxito angiográfico con la dislipidemia y la obesidad; y entre los pacientes sin éxito del procedimiento, con el tabaquismo y también con la obesidad. / Abstract Introduction: Coronary heart disease is the leading cause of morbidity and mortality in diabetic patients. Many studies have compared medical therapy plus percutaneous intervention with medical therapy plus surgery in diabetic patients with multivessel disease. Bypass surgery remains the treatment of choice. Objective: To characterize diabetic patients with multivessel

  11. Rabdomioma cardiaco tratado quirúrgicamente con éxito y revisión de la literatura

    OpenAIRE

    Cigarroa López,Ángel; García Jiménez,Yoloxóchitl; Yáñez Gutiérrez,Lucelly; Jiménez Arteaga,Santiago; Martínez Sánchez,Arturo; Ortegón Cardeña,José; David Gómez,Felipe; Sánchez Soberanes,Agustín; López Gallegos,Diana; Riera-Kinkel,Carlos; Alva Espinosa,Carlos

    2005-01-01

    Los tumores cardiacos primarios son raros, con incidencia variable en todas las edades del 0.005 al 0.05%. En pacientes pediátricos, la incidencia es del 0.27%. Los tumores más frecuentes durante la infancia son los rabdomiomas cardiacos, considerados como benignos. Aunque la expresión clínica es amplia, en la mayoría de los casos son asintomáticos y se detectan por la presencia de soplos. En la etapa prenatal se manifiestan con arritmias o hydrops fetalis. En algunos neonatos y lactantes se ...

  12. Técnica de aclaramiento para dientes tratados endodónticamente con antecedentes de trauma dentoalveolar - reporte de caso

    OpenAIRE

    Mariño Poveda, Adriana Carolina

    2014-01-01

    La pigmentación, de un diente anterior no vital es una preocupación estética común para muchos pacientes. Los dientes no vitales con decoloración están comprometidos, debido a un trauma previo, caries y endodoncia. Las opciones de tratamiento rehabilitador son invasivas y debilitan la estructura dental remanente, cuestionando la viabilidad a largo plazo del diente. Este documento analiza un enfoque más conservador para el tratamiento de los dientes con decoloración. El caso ...

  13. Evolución en niños con neumonía adquirida en la comunidad tratados con penicilina cristalina y/o amoxicilina

    OpenAIRE

    Bustamante Vélez, Victoria Helena

    2015-01-01

    La neumonía adquirida en la comunidad es una causa importante de morbimortalidad en la población pediátrica, su diagnóstico es básicamente clínico contando con ayudas de laboratorio; el Streptococcus pneumoniae es una agente frecuente en todas las edades, generalmente sensible al tratamiento con penicilina sus puntos de corte para resistencia fueron modificados en el 2007 . En el siguiente estudio se describe la evolución de pacientes diagnosticados con neumonía adquirida en la comunidad y tr...

  14. Síndrome de lisis tumoral en un paciente con cáncer de riñón tratado con sunitinib

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    Ezequiel Rodríguez-Reimúndes

    2011-04-01

    Full Text Available El síndrome de lisis tumoral (SLT es un trastorno metabólico que ocurre como consecuencia de una destrucción celular masiva. Se caracteriza por la presencia de hiperuricemia, hiperfosfatemia, hipocalcemia e hiperkalemia, y predispone al desarrollo de insuficiencia renal aguda. En la mayoría de los casos el SLT ocurre luego de instaurarse un tratamiento antitumoral y es más frecuente en tumores de alto grado de malignidad y alta sensibilidad a la quimioterapia. Presentamos el caso de un paciente con diagnóstico de cáncer de riñón recidivado que presenta un SLT e insuficiencia renal aguda luego de iniciar tratamiento con sunitinib.

  15. Evaluación longitudinal clínica, neuropsicológica y motora en primeros episodios psicóticos no tratados previamente con antipsicóticos

    OpenAIRE

    García de Jalón Aramayo, María Elena

    2015-01-01

    INTRODUCCIÓN: Las alteraciones cognitivas son una característica principal en los trastornos del espectro de la esquizofrenia que se relacionan con un peor pronóstico de la enfermedad. En esta tesis doctoral se incluyen cuatro artículos ya publicados (Cuesta et al., 2009), (Cuesta et al., 2011); (Cuesta et al., 2012); (Cuesta et al., 2013) sobre el rendimiento cognitivo en primeros episodios psicóticos no tratados previamente con antipsicóticos, así como su evolución a lo largo...

  16. Hipertensión arterial como factor predictivo en pacientes con cáncer renal tratados con antiangiogénicos

    OpenAIRE

    2011-01-01

    El conocimiento de las diversas vías de oncogénesis ha llevado al desarrollo en los últimos cinco años de nuevas terapias para el tratamiento del cáncer renal avanzado, las que poseen como blanco al factor derivado del endotelio vascular (VEGF) y sus receptores (antiangiogénicos) y al blanco mamífero de la rapamicina (mTOR). Los antiangiogénicos constituyen un grupo de moléculas activas con un espectro de toxicidad peculiar que comprende el desarrollo de hipertensión arterial, disfunción tiro...

  17. EVOLUCIÓN CLÍNICA DE PACIENTES CON INFARTO AGUDO DE MIOCARDIO TRATADOS CON ANGIOPLASTIA PRIMARIA / Clinical evolution of patients with acute myocardial infarction treated with primary angioplasty

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    Ernesto del Pino Sánchez

    2012-07-01

    Full Text Available ResumenIntroducción y objetivos: La angioplastia primaria restablece de manera rápida y mantenida la permeabilidad de la arteria coronaria responsable del infarto agudo de miocardio, disminuye significativamente la mortalidad, y mejora el pronóstico y la calidad de vida a largo plazo. El objetivo fue describir la evolución clínica de los pacientes con infarto agudo de miocardio tratados con angioplastia primaria. Método: Estudio descriptivo, longitudinal y prospectivo con 69 pacientes, recepcionados de 8:00 am a 4:00 pm, tratados con angioplastia primaria en el Instituto de Cardiología y Cirugía Cardiovascular, desde el 1 de julio de 2007 hasta el 31 de diciembre de 2008. Se realizó seguimiento clínico durante 180 días, donde se evaluó la frecuencia de sucesos clínicos mayores: muerte, reinfarto, angina postinfarto e inestable, necesidad de nueva revascularización y hemorragia mayor. Resultados: El tabaquismo y la hipertensión arterial tuvieron una prevalencia elevada. La localización inferior del infarto y la enfermedad de un vaso fueron las más frecuentes. Prevaleció el resultado inmediato exitoso. Los casos fallidos se relacionaron, con la coronaria derecha, el flujo TIMI 0 - 1 y el tiempo de evolución mayor de seis horas. Los sucesos clínicos mayores en el seguimiento fueron escasos y más frecuentes durante los primeros 30 días de seguimiento. Conclusiones: La angioplastia primaria realizada durante las primeras seis horas después del comienzo de los síntomas, es un procedimiento eficaz para tratar el infarto agudo de miocardio, debido al predominio del resultado exitoso y la escasa frecuencia de sucesos clínicos mayores durante seis meses de seguimiento clínico. / AbstractIntroduction and Objectives: Primary coronary angioplasty reestablishes fast and sustained way the permeability of acute myocardial infarction related artery. It decreases the mortality, improves the prognosis and quality of life to long-term. The

  18. Guía clínica de manejo para la atención de pacientes tratados con prótesis implantosoportada en la facultad de odontología de la Universidad Nacional de Colombia

    OpenAIRE

    Ramírez Jiménez, Mónica; García Bravo, Ana María

    2014-01-01

    Objetivo: Formular una guía clínica de manejo basada en la evidencia para la atención de pacientes tratados con prótesis implantosoportada en la Facultad de Odontología de la Universidad Nacional de Colombia. Metodología: Para la elaboración de la guía se revisaron las siguientes bases de datos: MedLine (PubMed), Science Direct, y Cochrane reviews, se seleccionaron un total de 43 artículos de la más alta evidencia disponible en la literatura, según la clasificación SIGN, referente a diagnó...

  19. Características seminales de verracos alimentados con dietas adicionadas con ácido linoleico conjugado o nucleótidos, y comportamiento sexual de verracos castrados tratados con PGF2α.

    OpenAIRE

    Zamora Zamora, Vicente

    2010-01-01

    La composición nutrimental de la dieta afecta las características del semen y composición de nutrientes del espermatozoide. El comportamiento sexual en machos no está completamente relacionado con las hormonas esteroides producidas en el testículo. Se realizaron dos experimentos para evaluar el potencial de la adición de ácido linoleico conjugado (ALC; experimento 1) o nucleótidos (experimento 2) a dietas para verracos para mejorar las características seminales y modificar el perfil de ácidos...

  20. Modificación de biomarcadores histopatológicos e inmunohistoquímicos en las fibras musculares de cerdos tratados con clenbuterol

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    AM Molina

    2012-01-01

    Full Text Available El clenbuterol frecuentemente se ha utilizado de forma ilícita en el engorde del ganado, suponiendo ello un riesgo para la salud pública. La actual normativa prohíbe por tanto su uso en la cría del ganado. En este estudio se utilizaron 14 cerdos distribuidos al azar en dos grupos de estudio (n=7, uno control, y otro expuesto a 1 mg/kg de clenbuterol durante tres meses. Se utilizó el músculo longissimus lumbaris para la determinación de la concentración de clenbuterol, así como para la evaluación de los parámetros inmunohistoquímicos y el análisis estructural y ultraestructural de las fibras. El estudio de los distintos biomarcadores histopatológicos e inmunohistoquímicos de las fibras musculares, tras la exposición de los animales al clenbuterol, indicó la presencia de hipertrofia muscular, miofibrolisis y degeneración zenkeriana, observada tanto por microscopía óptica como electrónica. Mediante la técnica miosina ATP-asa se identificó un tipo de fibra denominada alterada en el grupo tratado que no apareció en el grupo control. Por tanto, se comprueba que el músculo longissimus lumbaris resulta una buena matriz para la investigación de la exposición a largo plazo a este compuesto en cerdos.

  1. Velocidad de la onda de pulso y la excreción urinaria de albumina en pacientes hipertensos tratados con Perindopril

    OpenAIRE

    J. E. Tobilli; C. A. Bellido; O. R. Iavícoli; Costa, M; Forcada, P

    2002-01-01

    La presión arterial sistólica, la presión arterial diastólica y la excreción urinaria de albúmina (EUA) han sido reconocidas como predictores de riesgo cardiovascular. Además, los trastornos de la compliance arterial (CA) evaluados mediante la velocidad de la onda de pulso elevada (VOP) están estrechamente relacionados con los cambios de la presión arterial y correlacionados con la mortalidad cardiovascular y la presencia de ateroesclerosis. El objetivo primario de este estudio ha sido determ...

  2. Evolución clínica de pacientes asmáticos tratados con inmunoterapia. Municipio Majibacoa, 2008-2013

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    Mailin Molina Leyva

    2015-11-01

    Full Text Available Se realizó un estudio cuasi-experimental de corte longitudinal en 50 pacientes asmáticos con edades  entre 5 y 54 años, atendidos en el Servicio de Alergología del municipio Majibacoa de la provincia de Las Tunas; con el objetivo de determinar la evolución clínica con inmunoterapia, en el período de enero 2008 a febrero de 2013. A los pacientes se les administró inmunoterapia específica de ácaros con extractos estandarizados, durante tres años o más de forma subcutánea. El asma bronquial predominó en el sexo femenino y en las edades comprendidas entre 5 y 14 años. Los antecedentes de atopia familiar fueron referidos por el mayor por ciento de los pacientes analizados. Según severidad de la enfermedad, antes del tratamiento prevalecieron los pacientes en la categoría persistente moderada. Se observó mejoría de los síntomas del asma en una elevada proporción de casos.

  3. Análisis de pacientes drepanocíticos tratados con hidroxiurea en el Hospital Nacional de Niños

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    Rasheda Maitland-Rouse

    2014-06-01

    Full Text Available Antecedentes: desde 1984 estudios comprobaron que la hidroxiurea aumentaba los niveles de hemoglobina fetal y del volumen corpuscular medio, por esta razón a partir de 1998 fue el primer fármaco aprobado para el tratamiento en la drepanocitosis. El objetivo de este estudio fue describir la respuesta y complicaciones de los pacientes drepanocíticos en tratamiento con hidroxiurea en el Hospital Nacional de Niños. Métodos: estudio transversal y retrospectivo, realizado en pacientes con drepanocitosis atendidos en el servicio de Hematología del Hospital Nacional de Niños de enero 2006 a diciembre 2009; se incluyeron pacientes cuyo expediente clínico reunía los criterios de inclusión. Resultados: se reclutaron 30 pacientes, 60% fueron del sexo masculino, la mayoría de los pacientes fueron de Guanacaste, San José y Limón con un 26.7%, 23.3%y 20.0% respectivamente. Un 87% de los pacientes mantuvieron una velocidad de crecimiento normal. Al comparar la hemoglobina fetal previa y posterior al tratamiento con hidroxiurea no se obtuvo diferencia estadísticamente significativa. Al comparar el número de transfusiones anuales previas y posteriores a tratamiento con Hidroxiurea, se obtuvo una diferencia estadísticamente significativa. Se observó una disminución en el número de hospitalizaciones; las principales causas de internamiento fueron las crisis vasooclusivas, procesos sépticos y los accidentes cerebro vasculares. Conclusión: el uso de hidroxiurea en los pacientes drepanocíticos se asoció a una reducción en el número de hospitalizaciones por crisis vasoclusivas, al mismo tiempo se redujo el número de transfusiones anuales, sin efectos secundarios y sin comprometer la velocidad de crecimiento de los pacientes.

  4. Velocidad de la onda de pulso y la excreción urinaria de albumina en pacientes hipertensos tratados con Perindopril

    Directory of Open Access Journals (Sweden)

    J. E. Tobilli

    2002-12-01

    Full Text Available La presión arterial sistólica, la presión arterial diastólica y la excreción urinaria de albúmina (EUA han sido reconocidas como predictores de riesgo cardiovascular. Además, los trastornos de la compliance arterial (CA evaluados mediante la velocidad de la onda de pulso elevada (VOP están estrechamente relacionados con los cambios de la presión arterial y correlacionados con la mortalidad cardiovascular y la presencia de ateroesclerosis. El objetivo primario de este estudio ha sido determinar la relación entre la VOP y la EUA en un grupo de pacientes no fumadores con hipertensión esencial y secundariamente evaluar los cambios producidos por un inhibidor de la enzima convertidora de angiotensina (perindopril sobre estas dos variables. En el estudio participaron setenta pacientes (33 hombres y 37 mujeres hipertensos no fumadores, sin tratamiento previo, de 50 ± 7 años (entre 35-69. La VOP de todos los pacientes fue estudiada por medio de un dispositivo computarizado (Complior en el período basal y a los seis meses de tratamiento con perindopril. También se determinó la EUA por el método de inmunodifusión radial al inicio del tratamiento y luego de seis meses de tratamiento con perindopril (4.6 ± 1.4 mg/día. Al finalizar el estudio se observó una reducción significativa de la presión arterial sistólica (PAS (160.2 ± 10.6 vs. 131.9 ± 7.1 mmHg, p<0.01, presión arterial diastólica (PAD (100.6 ± 5 vs. 81.6 ± 4.8 mmHg, p<0.01, VOP (13.4 ± 1 vs. 9.1 ± 0.9 m/seg, p<0.01 y EUA (42.2 ± 19.3 vs.11.1 ± 3.6 mg/día, p<0.01 al comparar estos valores con los del período basal. Por otra parte, la función renal evaluada por clearance de creatinina mostró una significativa mejoría en relación a los valores iniciales (87.5 ± 22.5 vs. 102.1 ± 23.5 ml/min, p<0.01. Asimismo, se apreció una significativa correlación positiva entre la EUA y la VOP al inicio del estudio (r = 0.81; p<0.01 y después de seis meses de tratamiento

  5. COMPORTAMIENTO DE UN MATERIAL GRANULAR NO TRATADO EN ENSAYOS TRIAXIALES CÍCLICOS CON PRESIÓN DE CONFINAMIENTO CONSTANTE Y VARIABLE BEHAVIOR OF AN UNBOUND GRANULAR MATERIAL IN CYCLIC TRIAXIAL TESTS WITH CONSTANT AND VARIABLE CONFINING PRESSURE

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    Hugo Alexander Rondón Quintana

    2008-12-01

    Full Text Available En un pavimento, cada una de las capas de la estructura experimenta bajo una carga vehicular ciclos de esfuerzo con componentes vertical, horizontal y de corte. Para el estudio de materiales granulares no tratados (utilizados para conformar capas de base y subbase, la mayor parte de las investigaciones se realizan empleando equipos triaxiales cíclicos en donde sólo la carga vertical es cíclica y la presión de confinamiento permanece constante durante el ensayo. Un ensayo que reproduce mejor la forma como se distribuyen los esfuerzos en estas capas es el ensayo triaxial cíclico con presión de confinamiento variable. En este ensayo se pueden modelar las componentes cíclicas tanto en el sentido vertical como horizontal. A pesar que son ensayos distintos, la ingeniería de pavimentos supone que la respuesta que experimentan estos materiales en estos ensayos es similar, lo anterior basado en algunos estudios realizados en la década de los setenta. En la presente investigación se diseña y desarrolla un programa experimental más detallado, para comparar el comportamiento que desarrolla un material granular no tratado en estos ensayos. De los resultados se evidencia que sólo para algunas trayectorias de esfuerzo, la dirección y la acumulación de la deformación vertical y volumétrica es similar.In a pavement structure, passing wheel loads impose cyclic stresses consisting of vertical, horizontal and shear components. Studies of the behavior of unbound granular materials (UGM, used for base and sub-base layers under cyclic loading are mostly performed using the axisymmetric triaxial test with constant confining pressure (CCP test and a cyclic variation of the axial stress. However, in this type of test only the vertical component of the cyclic stress path is considered. The oscillation of the horizontal stress can be reproduced by an additional cyclic variation of the confining pressure (VCP test. CCP and VCP tests are sometimes assumed to

  6. Morfología de la mucosa gástrica oxíntica en ratones jóvenes tratados con omeprazol

    OpenAIRE

    Corrons, Félix J.; Jurado, Susana B.; Peralta, R.; Pomini, H.; Errecalde, J.; Drut, Ricardo

    2010-01-01

    El omeprazol es un potente inhibidor de la bomba de protones usado como antiácido en la práctica diaria. Actúa uniéndose en forma covalente a la enzima de membrana H+/K+ ATPasa en la etapa final de la estimulación secretora. En pacientes adultos y pediátricos se describen cambios en la mucosa gástrica con altas dosis en cortos periodos de tiempo

  7. Perfil eletrocardiográfico e conteúdo glicogênico muscular de ratos tratados com nandrolona Perfil electrocardiográfico y contenido glicogénico muscular de ratones tratados con nandrolona Electrocardiographic profile and muscle glycogen content of rats treated with nandrolone

    Directory of Open Access Journals (Sweden)

    Carlos Alberto da Silva

    2010-12-01

    áfico, contenido glicogénico y de proteínas totales de los músculos cardíacos y esqueléticos, así como las concentraciones plasmática de albúmina. MÉTODOS: Los animales del grupo tratado recibieron la droga en la concentración 5mg/kg por vía subcutánea, dos veces por semana, durante tres semanas. Una vez por semana, los ratones fueron anestesiados con Pentobarbital sódico (50mg/Kg, ip y sometidos a evaluación por medio de electrocardiograma (ECG. Después del período experimental, muestras de los músculos cardíaco (ventrículo izquierdo - VI, sóleo (S, gastrocnemio blanco (GB, gastrocnemio rojo (GV, pectoral (P, intercostal (IC y diafragma (D fueron colectadas y analizadas. Los datos (media±epm fueron evaluados de acuerdo con ANOVA, segundo test de Tukey (p>0,05. RESULTADOS: Los ratones del grupo tratado presentaron alteraciones en los siguientes parámetros cardíacos: intervalo QRS, intervalo QTc y frecuencia cardíaca, caracterizados por un aumento de estos, teniendo el ápice en el intervalo de la semana de pretratamiento a la primera semana. Las reservas de glicógeno en el VI presentaron aumento de 127%. En relación a la cantidad de proteínas totales, una diferencia significativa fue constatada en el S, GV y D. En cuanto al perfil bioquímico y al hematocrito, fue observado un aumento en el porcentaje de eritrocitos. CONCLUSIÓN: El estudio muestra que importantes alteraciones cardíacas son provocadas precozmente, sugiriendo una jerarquía en la secuencia de modificaciones que comprometen la homeostasia del organismo.BACKGROUND: We considered both the indiscriminate use of steroids by top athletes and by physically active individuals. OBJECTIVE: To evaluate the effects of nandrolone decanoate on the electrocardiographic profile, glycogen content and total-protein profile of skeletal and cardiac muscles, as well as the plasma albumin concentrations. METHODS: The drug was administered subcutaneously, at a concentration of 5 mg/kg, twice a week for three

  8. Las negociaciones comerciales de Colombia: del Área de Libre Comercio de las Américas (ALCA) a un Tratado de Libre Comercio (TLC) con Estado

    OpenAIRE

    Juan Carlos Ramírez

    2005-01-01

    La Oficina de Cepal en Colombia y la Fundación Friedrich Ebert en Colombia (FESCOL) organizaron tres seminarios alrededor de las negociaciones comerciales de Colombia. Esta iniciativa se desarrolló con la orientación de Wolf Grabendorff, director de FESCOL, Miguel Eduardo Cárdenas, coordinador de proyectos de FESCOL, y Juan Carlos Ramírez, director de la Oficina de Cepal en Colombia. Esta publicación agrupa la mayor parte de las ponencias realizadas en los seminarios "Escenarios para la inser...

  9. Análisis de los cambios verticales óseos y dentoalveolares en pacientes tratados con aparatos funcionales de avance mandibular

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    Claudet Angulo, Paola Consuelo

    2016-01-01

    Los odontólogos deben tener amplios conocimientos sobre el crecimiento y desarrollo craneofacial, incluso para quienes ocasionalmente trabajan con niños, porque es difícil entender los trastornos que presentan los adultos sin conocer los procesos de desarrollo que han dado lugar a estos trastornos. Para ello se debe conocer, como es lógico, las pautas normales de crecimiento y los mecanismos implicados en el mismo.1 La variación es una ley básica de la biología. Las variaciones se dan a nivel...

  10. La adhesión a los tratados internacionales como posibilidad de garantizar el derecho de las personas con problemáticas en salud mental

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    Solitario, Romina

    2009-01-01

    Esta presentación es un recorte del proyecto de tesis doctoral de la autora, que cuenta con una Beca Doctoral Tipo I del CONICET, y cuya Directora es la Prof. Alicia Stolkiner. El mismo se propone indagar cómo y en qué condiciones realizan sus derechos las personas que han estado internadas en instituciones psiquiátricas y han sido declaradas incapaces luego de haber atravesado un juicio de insania, una vez que retornan a sus comunidades de origen, para ser tratadas en programas comunitarios ...

  11. Características clínicas de pacientes tratados con terapia electroconvulsiva en un hospital público de Perú

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    Carla Cortez-Vergara

    2016-01-01

    Full Text Available Con el objetivo de describir el perfil de uso de la terapia electroconvulsiva (TEC en pacientes hospitalizados en el Instituto Nacional de Salud Mental "Honorio Delgado - Hideyo Noguchi" de Lima, Perú, se revisaron las historias clínicas de pacientes que recibieron TEC entre los años 2001 y 2011. Se aplicaron 419 cursos de TEC a 372 pacientes, con un total de 5439 aplicaciones; la esquizofrenia paranoide fue el diagnóstico más frecuente (70,7%, y la indicación más usual fue la resistencia al tratamiento (80,7%; asimismo, la respuesta clínica a la TEC fue buena en 70,1% de casos, mientras que los efectos secundarios, en general, fueron pasajeros y leves. El uso de TEC disminuyó a lo largo del periodo estudiado, pero fue muy tolerable y segura, especialmente en su versión modificada, y mostró una alta respuesta que la mantiene como un tratamiento psiquiátrico de primera línea.

  12. El ejercicio de la soberanía territorial de acuerdo con los tratados y principios del derecho internacional. El caso colombiano

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    Germán Ramírez Bulla

    2008-01-01

    Full Text Available La importancia del estudio del territorio como elemento del Estado, necesario para su existencia como sujeto del derecho internacional, que ejerce su soberanía territorial y debe respetar la de los demás como presupuesto para el mantenimiento de la paz y la seguridad internacionales, conduce a hacer algunas reflexiones sobre ciertos principios contenidos en las cartas de la onu y la oea y en otros instrumentos internacionales. El territorio como ámbito espacial en el que el Estado ejerce su soberanía, de manera excluyente para terceros que no deben intervenir en los asuntos internos, es también un espacio en el que las autoridades deben hacer cumplir el ordenamiento vigente. La Constitución del 91, al enumerar espacios que hacen parte de Colombia, reconoce la idea de la tridimensionalidad del territorio y cada uno de esos elementos es definido acogiendo o teniendo en cuenta normas del derecho internacional y del interno, con el objeto de precisar conceptos de manera que pueda haber una visión integral, no solamente del espacio físico, sino de la manera como el Estado se proyecta en sus relaciones exteriores, de acuerdo con una serie de principios que conforman un ordenamiento aceptado por la comunidad internacional.

  13. Dosis elevadas de aspirina disminuyen la natriuresis en hipertensos tratados con enalapril High doses of aspirin reduce natriuresis in hypertensive patients treated with enalapril

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    Federico P. Di Gennaro

    2004-08-01

    Full Text Available Los inhibidores de la enzima convertidora de la angiotensina (IECA han demostrado ser eficaces en el tratamiento de la hipertensión arterial. Sin embargo, una importante proporción de hipertensos recibe además antiagregación plaquetaria con ácido acetil salicílico (AAS, y la consecuente inhibición de la síntesis de prostaglandinas con AAS atenuaría el efecto vasodilatador y la mayor excreción urinaria de sodio (Na u atribuidas al IECA. Nuestro objetivo fue evaluar la interacción de dos dosis de AAS (81 y 325 mg/día sobre el efecto hipotensor del enalapril y el impacto sobre la excreción de Na u en pacientes hipertensos. Se incluyeron 22 pacientes de ambos sexos, entre 35 y 65 años. Todos recibieron enalapril, dieta hiposódica y, secuencialmente separadas por período de «wash out», las dos dosis de AAS durante los setenta días del estudio. Se evaluó: presión arterial sistólica (PAS, diastólica (PAD, media (PAM y Na u en un período basal (PB, con 325 y 81 mg de AAS (P1 y P2 respectivamente. Comparando el PB con P1 y P2, se observó una reducción significativa de la PAS, PAD, PAM (pAngiotensin converting enzyme inhibitors have been shown to be useful in the treatment of essential hypertension while anti-platelet agents improve the overall cardiovascular risk profile in this population. Our aim was to assess the interaction of two different aspirin (ASA doses -81 and 325 mg/day- with the antihypertensive effect of enalapril as well as their impact upon the urinary sodium excretion (Na u. A total of 22 patients between 35 and 65 years of age were included in a prospective double blind trial with a partial cross-over design. We excluded patients with secondary hypertension and recent use of anti-inflammatory drugs. Patients were placed on enalapril and a low sodium diet -<6 g of NaCl/day- and, sequentially, on two different doses of aspirin separated by a 10 day wash out period. Blood pressure (BP was measured at weekly visits

  14. Valor predictor del cociente saturación hemoglobina/fio2 en pacientes pediátricos con insuficiencia respiratoria aguda debida a neumonía tratados con ventilación no invasiva. Predictive value of the pulse oximetric saturation/fraction of inspired oxygen ratio in pediatric patients with acute respiratory failure due to pneumonia treated with non-invasive ventilation

    OpenAIRE

    Palanca Arias, Daniel

    2014-01-01

    RESUMEN: El uso de la ventilación no invasiva (VNI) en pacientes con fracaso respiratorio hipoxémico debido a neumonía es controvertido, alcanzando elevadas tasas de fracaso en el Síndrome de Distrés Respiratorio Agudo (SDRA). Recientemente, el cociente SpO2/FiO2 (SF) se ha equiparado al cociente paO2/FiO2 (PF) para la valoración del SDRA. Determinamos en una cohorte de pacientes, diagnosticados de neumonía y tratados con VNI, si el cociente SF es una variable con valor predictor de fraca...

  15. Embarazo ectópico cervical tratado con metotrexate: Reporte de un caso Ectopic cervical pregnancy treated with methotrexate: A case report

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    Rodolfo Valentín Martínez Camilo

    2000-08-01

    Full Text Available Se presenta el caso de una paciente con embarazo ectópico cervical, a quien se le administró metotrexate sistémico como alternativa al tratamiento quirúrgico. La terapia medicamentosa consistió en la administración de 50 mg de metotrexate por vía endovenosa en días alternos, en un total de 4 dosis, así como el uso de ácido fólico por vía oral a razón de 1 tableta de 5 mg cada 12 horas, en los días en que no se administró metotrexate. Se controló el caso con láminas periféricas evolutivas y ultrasonografía. Se confirmó la destrucción del embarazo por resultados histológicos. Se considera que en el embarazo ectópico cervical, el uso de metotrexate puede ser utilizado como tratamiento conservador. El embarazo ectópico es una afección muy importante en Ginecología,¹ y constituye una entidad en que el óvulo fecundado se implanta en otro sitio que no es la cavidad uterina.² El embarazo cervical es una forma rara de embarazo ectópico, donde el huevo se implanta en el canal cervical y lo distiende a medida que crece.3,4 La hemorragia indolora es su característica clínica habitual5 y al examen físico se observa un cérvix hipertrófico muy vascularizado, con un tejido que sobresale por el orificio externo.6 Como complementario útil para el diagnóstico se puede usar la ultrasonografía, en la que se demuestra de forma directa la presencia de un saco gestacionalThe case of a patient with ectopic cervical pregnancy that was systematically administered methotrexate as an alternative to surgical treatment is presented. Drug therapy consisted in the administration of 4 doses of. 50 mg of methotrexate by endovenous route every other day. Patients received folic acid at doses of 1 tablet of 500 mg every 12 hours when methotrexate was not administered. The case was controlled with evolutive peripheral plates and ultrasonography. The destruction of pregnancy was confirmed by histological results. It is considered that

  16. Síndrome de lisis tumoral "espontáneo" en paciente con enfermedad de Crohn tratado con inmunosupresores Acute spontaneous tumor lysis syndrome in a patient with Crohn's disease taking immunosuppressants

    OpenAIRE

    C. Froilán Torres; P. Castro Carbajo; R. Pajares Villarroya; R. Plaza Santos; S. Gómez Senent; M. D. Martín Arranz; L. Adán Merino; E. Martín Arranz; N. Manceñido Marcos; R. Peces; D. Benito López

    2009-01-01

    El síndrome de lisis tumoral (SLT) es una complicación catastrófica del tratamiento de ciertas enfermedades neoplásicas. Si bien es más frecuente en pacientes con neoplasias hematológicas malignas tras el inicio de la quimioterapia, puede presentarse excepcionalmente, tras la necrosis espontánea de algunos tumores, en ausencia de tratamiento citostático. Clínicamente cursa con hiperuricemia, hiperfosfatemia, hipocalcemia, hiperpotasemia y fallo renal agudo. Presentamos el caso de un paciente ...

  17. Características y resultado a largo plazo de pacientes mayores con leucemia promielocítica aguda tratados con esquemas terapéuticos basados en ATRA más antraciclinas

    OpenAIRE

    Martínez Cuadrón, David

    2015-01-01

    La leucemia promielocítica aguda (LPA) es un subtipo de leucemia mieloide aguda que se diferencia por una morfología característica y la presencia de la t(15;17) y su correspondiente reordenamiento molecular PML/RARa. Clínicamente, no es infrecuente que se presente con coagulopatía, pudiendo ser la responsable de la muerte del paciente incluso antes del diagnóstico. No obstante, su buena respuesta al tratamiento con ácido holo-trans retinoico (ATRA) se ha traducido en una importante mejoría d...

  18. Treatment with pegylated interferon alpha 2b and ribavirin in patients unresponsive to previous treatments with standard interferon as monotherapy or combined with ribavirin Tratamiento con PEG interferón alfa 2b y ribavirina en enfermos previamente tratados con interferón estándar en monoterapia o combinado con ribavirina

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    F. Carnicer

    2005-05-01

    Full Text Available Background: little information is available on the effect of pegylated interferon (PEG and ribavirin (RBV in patients with chronic hepatitis due to virus C (CHC who were non-responders to previous treatment. Objectives: to evaluate response to treatment in patients who were non-responders to previous treatment. Methods: one hundred and twenty-four patients who were non-responders to previous treatment were included. All patients were treated with PEG alpha 2b interferon (dose: 1.5 mg/kg body weight and RBV (weight-dependent dosage. A qualitative PCR of virus C after six months was evaluated. In those in whom this was positive, treatment was discontinued; in those who were negative treatment was continued to the end of the year. Results: response following treatment (RFT was 35.4% (44 patients, and sustained viral response (SVR 29.8% (37 patients. No relation was observed between RFT, SVR and any previous treatment. RFT was dependent on low initial viremia and SVR was significantly and independently related to low serum hepatitis C RNA and a non-1 genotype. In general, treatment was well tolerated. Medication was discontinued in 5 patients, and doses reduced in 18. Conclusion: on retreatment with PEG and RBV a SVR of 29.8% was achieved in patients who had not responded to previous treatment, so its use in this group of patients is indicated.Introducción: existe poca información del resultado del tratamiento con interferón pegilado (PEG y ribavirina (RBV en enfermos con hepatitis crónica por virus C (HCC no respondedores a tratamientos previos. Objetivos: valorar la respuesta al tratamiento en enfermos no respondedores a tratamientos anteriores. Métodos: se incluyeron 124 enfermos no respondedores a tratamientos previos. Todos los pacientes fueron tratados con PEG interferón alfa 2b (dosis: 1,5 mg/kg peso y RBV (dosis ajustada al peso. Se valoró la PCR cualitativa del virus C al 6º mes. A los que la presentaban positiva se suspendió el

  19. Perfil clínico epidemiológico de los pacientes con cáncer tratados en una institución de tercer nivel. Manizales, Colombia, 1995-2004

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    Carlos Raúl Villegas

    2012-02-01

    Full Text Available Antecedentes: Los diagnósticos de cáncer son cada vez mayores y ello está asociado con el aumento de la expectativa de vida, la exposición a carcinógenos, la cobertura en salud, el tamizaje y la búsqueda activa de casos. En Estados Unidos se diagnostican 1’000,000 de casos nuevos y más de 500,000 muertes por año. Los costos de laatención y la incapacidad laboral son muy altos. En Colombia, el patrón de ocurrencia de esta enfermedad se constituye en un problema de salud pública. En Manizales, en el año 2004, se diagnosticaron 653 casos nuevos. Objetivo: Describir la población con diagnóstico de cáncer atendida en el Instituto Oncológico (ION SA de Manizales, Colombia, desde su fundación en el año 1995, hasta diciembre de 2004.Métodos: Se incluyeron 5,000 pacientes tratados durante 1995 a 2004. Las variables demográficas y clínicas se analizaron para establecer las frecuencias de presentación y los principales aspectos del manejo y los resultados del tratamiento.Resultados: Edad promedio 57 años +17.3; sexo femenino (65.6%; procedencia urbana (90.2%. La principal categoría ocupacional fue «Oficios varios» (61% seguida de «Técnico» (12.1%. Los diagnósticos con mayor frecuencia fueron cáncer de mama (18.7%, cáncer de cérvix (13.1%, linfomas (7.7%, cáncer colorectal (6.4% y cáncer gástrico (4.7%. La mayoría de los pacientes (69.1% consultó después de dos meses de presentar síntomas. Las etapas clínicas III y IV fueron las más frecuentes en el momento de la consulta. Según la escala de Karnofsky, la capacidad funcional era buena al inicio del tratamiento. El manejo general se hizo con cirugía, quimioterapia y radioterapia. La toxicidad medicamentosa se presentó en 11.3% (567/5,000. La supervivencia a 5 años para hombres y mujeres fue de 61.2% y 72.3%, respectivamente (p<0.05.Conclusión: El perfil clínico y epidemiológico de los pacientes atendidos en el ION SA, mantiene las tendencias mundialmente

  20. Perfil clínico epidemiológico de los pacientes con cáncer tratados en una institución de tercer nivel. Manizales, Colombia, 1995-2004

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    Carlos Raúl Villegas

    2012-02-01

    Full Text Available Antecedentes: Los diagnósticos de cáncer son cada vez mayores y ello está asociado con el aumento de la expectativa de vida, la exposición a carcinógenos, la cobertura en salud, el tamizaje y la búsqueda activa de casos. En Estados Unidos se diagnostican 1’000,000 de casos nuevos y más de 500,000 muertes por año. Los costos de la atención y la incapacidad laboral son muy altos. En Colombia, el patrón de ocurrencia de esta enfermedad se constituye en un problema de salud pública. En Manizales, en el año 2004, se diagnosticaron 653 casos nuevos.Objetivo: Describir la población con diagnóstico de cáncer atendida en el Instituto Oncológico (ION SA de Manizales, Colombia, desde su fundación en el año 1995, hasta diciembre de 2004.Métodos: Se incluyeron 5,000 pacientes tratados durante 1995 a 2004. Las variables demográficas y clínicas se analizaron para establecer las frecuencias de presentación y los principales aspectos del manejo y los resultados del tratamiento.Resultados: Edad promedio 57 años +17.3; sexo femenino (65.6%; procedencia urbana (90.2%. La principal categoría ocupacional fue «Oficios varios» (61% seguida de «Técnico» (12.1%. Los diagnósticos con mayorfrecuencia fueron cáncer de mama (18.7%, cáncer de cérvix (13.1%, linfomas (7.7%, cáncer colorectal (6.4% y cáncer gástrico (4.7%. La mayoría de los pacientes (69.1% consultó después de dos meses de presentar síntomas.Las etapas clínicas III y IV fueron las más frecuentes en el momento de la consulta. Según la escala de Karnofsky, la capacidad funcional era buena al inicio del tratamiento. El manejo general se hizo con cirugía, quimioterapia yradioterapia. La toxicidad medicamentosa se presentó en 11.3% (567/5,000. La supervivencia a 5 años para hombres y mujeres fue de 61.2% y 72.3%, respectivamente (p<0.05.Conclusión: El perfil clínico y epidemiológico de los pacientes atendidos en el ION SA, mantiene las tendencias mundialmente

  1. Síndrome de lisis tumoral "espontáneo" en paciente con enfermedad de Crohn tratado con inmunosupresores Acute spontaneous tumor lysis syndrome in a patient with Crohn's disease taking immunosuppressants

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    C. Froilán Torres

    2009-04-01

    Full Text Available El síndrome de lisis tumoral (SLT es una complicación catastrófica del tratamiento de ciertas enfermedades neoplásicas. Si bien es más frecuente en pacientes con neoplasias hematológicas malignas tras el inicio de la quimioterapia, puede presentarse excepcionalmente, tras la necrosis espontánea de algunos tumores, en ausencia de tratamiento citostático. Clínicamente cursa con hiperuricemia, hiperfosfatemia, hipocalcemia, hiperpotasemia y fallo renal agudo. Presentamos el caso de un paciente con enfermedad de Crohn en tratamiento inmunospresor, que desarrolló un síndrome de lisis tumoral espontáneo como debut de un plasmocitoma. Al ingreso, se objetivó un fracaso renal oligoanúrico que, a pesar de tratamiento precoz con hiperhidratación, alcalinización de la orina, urato-oxidasa y hemodiálisis, tuvo un desenlace fatal en 72 horas. Este caso reviste un interés particular por lo excepcional de la naturaleza "espontánea" del síndrome de lisis tumoral en ausencia de quimioterapia, por presentarse con una hiperuricemia extrema, probablemente la más alta de las recogidas en la literatura, y por la controversia actual de la terapia con inmunosupresores y/o biológicos en la enfermedad inflamatoria intestinal y su relación con el desarrollo de determinados tumores.Acute tumour lysis syndrome (TLS is a catastrophic complication of the treatment of certain neoplastic disorders. It most commonly occurs in association with hematologic malignancies and appears a few hours to a few days after initiation of specific chemotherapy, as the result from the release of intracellular components into the bloodstream due to abrupt malignant cell death. Acute spontaneous TLS is rare, and it has been described in leukemia and lymphoma and in some patients with solid tumors prior to institution of therapy. The syndrome is characterized by hyperuricemia, hyperphosphatemia, hypocalcemia, hyperkalemia, and acute oliguric or anuric renal failure due to

  2. Hipertensión arterial como factor predictivo en pacientes con cáncer renal tratados con antiangiogénicos Hypertension as predictive factor in renal cell cancer treated with antiangiogenic therapy

    OpenAIRE

    Luciana Gennari; Javier Belinky; Claudio Graziano; Gustavo Jankilevich

    2011-01-01

    El conocimiento de las diversas vías de oncogénesis ha llevado al desarrollo en los últimos cinco años de nuevas terapias para el tratamiento del cáncer renal avanzado, las que poseen como blanco al factor derivado del endotelio vascular (VEGF) y sus receptores (antiangiogénicos) y al blanco mamífero de la rapamicina (mTOR). Los antiangiogénicos constituyen un grupo de moléculas activas con un espectro de toxicidad peculiar que comprende el desarrollo de hipertensión arterial, disfunción tiro...

  3. Síndrome de lisis tumoral en un paciente con cáncer de riñón tratado con sunitinib Tumor lysis syndrome in a patient with a renal carcinoma treated with sunitinib

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    Ezequiel Rodríguez-Reimúndes

    2011-04-01

    Full Text Available El síndrome de lisis tumoral (SLT es un trastorno metabólico que ocurre como consecuencia de una destrucción celular masiva. Se caracteriza por la presencia de hiperuricemia, hiperfosfatemia, hipocalcemia e hiperkalemia, y predispone al desarrollo de insuficiencia renal aguda. En la mayoría de los casos el SLT ocurre luego de instaurarse un tratamiento antitumoral y es más frecuente en tumores de alto grado de malignidad y alta sensibilidad a la quimioterapia. Presentamos el caso de un paciente con diagnóstico de cáncer de riñón recidivado que presenta un SLT e insuficiencia renal aguda luego de iniciar tratamiento con sunitinib.The tumor mor lysis syndrome (TLS is a metabolic disorder resulting from a massive tumor breakdown. It is characterized by hyperuricemia, hyperphosphatemia, hypocalcemia and hyperkalemia and predisposes to acute renal failure. TLS usually occurs after the initiation of cytotoxic therapy and is more frequent in the case of neoplasias with a high proliferative rate or that are highly chemo-sensitive. We report the case of a man with a recurrent kidney cancer who presented with a TLS and acute renal failure after initiation of sunitinib.

  4. Pro-hepcidina, su relación con indicadores del metabolismo del hierro y de inflamación en pacientes hemodializados tratados o no con eritropoyetina recombinante Pro-hepcidin, its relation with indicators of iron metabolism and of inflammation in patients hemodialyzed treated or not with recombinant erythropoietin

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    Y. Barrios

    2010-08-01

    Full Text Available La hepcidina, péptido antimicrobiano, cuya síntesis se encuentra regulada por el estado del hierro e inflamación, juega un importante papel en la homeostasis del hierro en pacientes hemodializados (HD. Es medida a través de la prohepcidina sérica. Objetivo: Determinar los niveles séricos de prohepcidina y su relación con ferritina sérica, proteína C reactiva (PCR y albúmina en pacientes HD tratados o no con eritropoyetina recombinante (EPO, que asistieron a un Centro de Salud del Estado Carabobo-Venezuela. Metodología: Esta investigación es de tipo descriptiva, correlacional y de campo, cuya muestra estuvo conformada por 71 pacientes HD; 57 de éstos tratados con EPO. Se determinó prohepcidina sérica, ferritina, hemoglobina, hematocrito, PCR y albúmina. Se definió anemia (hemoglobina 10 mg/L. Resultados: El promedio para la prohepcidina fue de 397,5 ng/mL. Se observó un alto porcentaje de anemia (87,3% y un 22,5% de pacientes con ferritina sérica baja. No se observaron diferencias estadísticamente significativas para ferritina, albúmina, PCR y prohepcidina, entre pacientes con y sin tratamiento con EPO. Solo la variable PCR se correlaciona significativamente (rho = 0,276; p =0,020, con prohepcidina. Conclusión: Pacientes HD presentan niveles elevados de prohepcidina, esto pudiera deberse al proceso inflamatorio frecuentemente observado en estos pacientes y no al estado de hierro medido a través de los niveles de ferritina sérica.Hepcidin, an antimicrobial peptide which synthesis is regulated by iron status and inflammation, plays an important role in iron homeostasis in hemodialysed (HD patients. It is measured by measuring serum prohepcidin. Objective: To determine serum prohepcidin levels and their relationship with serum ferritin, C reactive protein (CRP, and albumin in HD patients treated or not with recombinant erythropoietin (EPO that attended the Health Centre of the Carabobo State in Venezuela. Methodology: This is

  5. El Tratado De Dilectione Dei de Balduino de Ford

    OpenAIRE

    Carlos Hallet

    2004-01-01

    Figura relevante de la Orden del Císter, Balduino de Ford es un autor que se distingue por la originalidad de su espiritualidad. Su tratado De dilectione Dei es una meditación sobre el Primer Mandamiento, que nos invita a amar a Dios "con todo el corazón en sus beneficios, con toda el alma en sus promesas, con todas las fuerzas en sus juicios y con toda la mente en sus preceptos". Su reflexión, nutrida de la Biblia y expresada en un lenguaje marcado por la retórica latina, insiste en que el a...

  6. Trastornos del sueño e incidencia de ansiedad y depresión en pacientes con dolor crónico no maligno tratados con opioides potentes Sleep disorders and incidence of anxiety and depresion in patients with chronic nonmalignant pain treated with strong opioids

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    I. Velázquez

    2012-04-01

    Full Text Available Introducción: acompañando al dolor están presentes otras funciones biológicamente importantes, no siempre bien reconocidas que suelen denominarse "co morbilidades", una de ellas es el sueño, aunque también se ha demostrado cierta concordancia entre el estado anímico y la nocicepción, siendo los dos estados de ánimo más estudiados y considerados como más relevantes en relación con el dolor crónico, la ansiedad y la depresión. Objetivo: el objetivo principal es evaluar la calidad del sueño en pacientes con dolor crónico no maligno (DCNM tratados con opioides potentes. Y como objetivos secundarios: analizar la incidencia de ansiedad y depresión en estos pacientes así como comparar la calidad del sueño e incidencia de ansiedad-depresión con distintas variables: tipo de opioide, género, sexo y tipo de dolor. Material y métodos: se consideró como universo del estudio a pacientes con DCNM tratados con el mismo opioide potente durante, al menos, tres meses y que acudieron a la consulta de Unidad del Dolor entre septiembre de 2009 y marzo de 2010. Fueron excluidos pacientes menores de 18 años, aquellos que no quisieron colaborar, diagnosticados de fibromialgia y los que estuvieran en tratamiento psiquiátrico. Como instrumento evaluador del sueño se utilizó el Cuestionario Oviedo de Sueño (COS y para mensurar el grado de ansiedad-depresión empleamos el Test Hospitalario de Ansiedad y Depresión (HAD en su valoración global. El análisis estadístico se realizó para las variables cualitativas mediante la χ² de Pearson. Las variables cuantitativas se compararon con un test de Student. Los valores con un p-valor menor que 0,05 fueron aceptados como significativos (95% de intervalo de confianza. Se usó el paquete estadístico SPSS.15 para Windows. Resultados: en la evaluación de los trastornos del sueño se encontraron diferencias significativas según el tipo de opioide consumido, siendo el grupo tratado con hidromorfoma el

  7. Audición y lenguaje en niños menores de 2 años tratados con implantación coclear Hearing and speech in children under 2 years of age with a cochlear implant

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    M. Manrique

    2004-12-01

    Full Text Available Fundamento. Valorar los resultados auditivos y de lenguaje en niños con una sordera congénita tratados mediante implantación coclear antes de los 2 años de edad y analizar las complicaciones surgidas en el proceso de selección, cirugía, programación y seguimiento de estos niños. Material y métodos. Se estudiaron 130 niños de forma prospectiva mediante la comparación de sus resultados individuales repetidos. Los niños se dividieron en dos grupos de edad: menores de 2 años (n=36 y niños entre 2 y 6 años (n=94. La valoración preoperatoria incluyó: 1. Historia, exploración física y ORL. 2. Valoración neuropediátrica, familiar y psicológica. 3. Potenciales auditivos troncoencefálicos. 4. Tomografía computarizada de alta resolución de peñascos. 5. Consejo terapéutico y consentimiento informado. La audición y el lenguaje se valoraron, antes y anualmente después de la cirugía (hasta 5 años, mediante pruebas logoaudiométricas en contexto cerrado y abierto, y con la prueba de Peabody y las escalas de Reynell. Resultados. La audición y el lenguaje mejoraron significativamente en todos los niños, independientemente de su edad. Los resultados, sin embargo, fueron mejores en los niños implantados antes de 2 años. Las pruebas de lenguaje mostraron que el desarrollo del lenguaje en estos niños es comparable al de niños normo-oyentes. La tasa de complicaciones no aumentó en los niños menores de 2 años. Conclusiones. La implantación coclear antes de los 2 años, ofrece unos resultados auditivos y de lenguaje mejores y más rápidos, en comparación con los alcanzados por niños de mayor edad, sin aumento de las complicaciones.Background. To compare the auditory abilities and speech performance of children with a profound prelingual bilateral hearing impairment, treated with a cochlear implant (CI before or after 2 years of age. To analyze the complications arising during the selection process of the children, or as a

  8. La ruptura de las relaciones diplomáticas: Una aproximación sistemática con una referencia especial a las consecuencias de la entrada en vigor del tratado de Lisboa en la praxis diplomática

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    Carles Pérez-Desoy i Fages

    2013-12-01

    Full Text Available Este trabajo tiene por objeto ofrecer un análisis sistemático de las distintas formas en que puede producirse la ruptura de relaciones diplomáticas entre dos estados soberanos, así como de las diversas fases en que puede descomponerse un proceso de este tipo, caracterizadas por la adopción de distintos tipos de medidas diplomáticas y la combinación de unas con otras (llamada a consultas, retirada de Embajadores, etc. lo que constituye un lenguaje de signos decodificable en términos diplomáticos, que ha sido poco estudiado desde un punto de vista sistemático. El elemento casuístico es, necesariamente, muy importante, máxime cuando las referencias a esta cuestión dentro de las normas codificadas del Derecho Diplomático son muy limitadas, y la jurisprudencia es con frecuencia inexistente. Por otra parte, la entrada en vigor del Tratado de Lisboa, y la puesta en marcha del Servicio de Acción Exterior Europeo (SEAE abre la posibilidad de que, en caso de crisis diplomática, acciones características de la diplomacia clásica puedan ser aplicadas también en el marco del proceso de toma de decisiones colectivas de la UE, ampliando así significativamente la panoplia de posibles medidas a adoptar. La entrada en vigor del Tratado de Lisboa abre también nuevas opciones teóricas de gran interés en el caso de ruptura de relaciones diplomáticas de un Estado Miembro de la UE con un tercer Estado, como por ejemplo la posible creación de una "sección de intereses" de ese Estado en el seno de la Delegación de la UE en ese país

  9. El Tratado de Lisboa (Un juego de espejos rotos

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    Juan Manuel de Faramiñán Gilbert

    2009-01-01

    Full Text Available El fracaso del Tratado por el que se establece una Constitución para Europa produjo un periodo de incertidumbre y perplejidad del que ha costado mucho sobreponerse. Por un momento, todo parecía resquebrajarse y se tuvo la sensación de que la imagen de unidad en la diversidad, que con tanta dificultad se había forjado, se partía hecha añicoscomo un espejo roto. No obstante, como en un “juego de espejos rotos”, el ideal europeísta se ha ido recomponiendo con un gran esfuerzo, dando lugar a un texto, el Tratado de Lisboa, que encierra una solución de compromiso con el fin de saldar la crisis cuando el futuro de la Unión Europea parecía oscurecerse. Como en los poemas de Alejandra Pizarnik, “cuando el palacio de la noche encierra su hermosura, pulsaremos los espejos hasta que nuestros rostros canten como ídolos” y, así fue como con un esfuerzo milimetrado se ha ido recomponiendo este rompecabezas de cristales con el fin de que en él se refleje, otra vez, la ansiada imagen global. Como se señala enPreámbulo del Tratado de Lisboa, deberemos estar resueltos a salvar una nueva etapa en proceso de integración europea y habrá que recordar “la importancia histórica de que la división del continente europeo haya tocado a su fin y la necesidad de sentar unas bases firmes para la construcción de la futura Europa”.

  10. Descripción del estado de salud y calidad de vida en pacientes tratados con etanercept dentro de un programa de atención para artritis reumatoide en un centro especializado en Colombi

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    Edwin Antonio Jáuregui Cuartas; Oswaldo Sánchez Villalobos; Martín Emilio Romero Prada; Rubén Darío Mantilla Hernández; María Concepción Maldonado López; Andrés Alfonso González Romero; Aura María Domínguez Perilla; Yenny Soraida Valero Morales; Carlos Augusto Morales Cruz; María Clara Trounchon Osorio; Carolina Cardona Martínez; Yesid Alberto Muñoz Urrego

    2013-01-01

    Resumen Objetivo: Realizar un análisis descriptivo de la actividad de la enfermedad medida por DAS28, de la funcionalidad medida por HAQ (Health Assessment Questionnaire) y escala de depresión, tras un año de seguimiento en un programa de gerenciamiento de la enfermedad «Evaluación día», para pacientes colombianos con artritis reumatoide que iniciaron tratamiento con etanercept (Enbrel®). Materiales y métodos: Se diseñó un programa como parte del manejo integral de la enfermedad que comprendí...

  11. Velocidad de la onda de pulso y la excreción urinaria de albumina en pacientes hipertensos tratados con Perindopril Pulse wave velocity and urinary albumin excretion in hypertensive patients treated with perindopril

    OpenAIRE

    J. E. Tobilli; C. A. Bellido; O. R. Iavícoli; Costa, M; Forcada, P

    2002-01-01

    La presión arterial sistólica, la presión arterial diastólica y la excreción urinaria de albúmina (EUA) han sido reconocidas como predictores de riesgo cardiovascular. Además, los trastornos de la compliance arterial (CA) evaluados mediante la velocidad de la onda de pulso elevada (VOP) están estrechamente relacionados con los cambios de la presión arterial y correlacionados con la mortalidad cardiovascular y la presencia de ateroesclerosis. El objetivo primario de este estudio ha sido determ...

  12. El avance del derecho a la buena Administración en el Tratado de Lisboa

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    Guillem Carrau, Javier

    2010-01-01

    El Tratado de Lisboa liga directamente el derecho a la buena administración con los principios de trasparencia y participación. Este avance debe garantizar que el derecho a la buena administración no quede limitado por un excesivo carácter programá

  13. EFECTO DE VARIOS NIVELES DE TREONINA: LISINA SOBRE PARAMÉTROS PRODUCTIVOS EN CERDOS EN FINALIZACION TRATADOS CON RACTOPAMINA EFFECT OF VARIOUS LEVELS OF THREONINE: LYSINE ON PRODUCTION PARAMETERS IN FINISHING PIGS TREATED WITH RACTOPAMINE

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    Jaime Eduardo Parra Suescún

    2008-06-01

    Full Text Available Para determinar el efecto de la adición de Ractopamina (RAC y la relación Treonina:Lisina (Thr:Lys sobre los rendimientos productivos, se realizó un experimento durante 28 días. Para este fin se utilizaron 42 cerdos de aproximadamente 72,4± 2,3 kg, en los cuales se evaluó el efecto de dos niveles de RAC (5 y 10 ppm y tres relaciones Thr:Lys (0,60; 0,65 y 0,70 en la dieta, sobre el consumo de alimento diario (CDA, la ganancia diaria de peso (GDP, ganancia diaria de tejido magro libre de grasa (GDTMLG, y además, la eficiencia (Ef se expresó como GDTMLG en función del CDA. El experimento se realizó mediante un diseño completamente al azar con arreglo factorial 3x2 y se hizo un análisis de medidas repetidas en el tiempo. Todas las variables fueron medidas en cada animal 14 y 28 días después de iniciado el suministro de la dieta. Los valores medios/animal/día de todas las variables presentaron interacciones. En general se observó que niveles altos de Rac tuvieron un mejor desempeño con niveles bajos o intermedios de Thr:Lys mientras que los niveles bajos de Rac tuvieron mejores resultados con niveles altos de Thr:Lys. Por esta razón, es de esperarse que las diferencias entre las variables con los dos niveles de Rac se deban al manejo nutricional (relación Thr:Lys, ya que este factor influencia la magnitud de la respuesta. Desde el punto de vista productivo, la combinación a recomendar es 10 ppm de Rac y Thr:Lys 0,6.To determine the effect of adding Ractopamine (RAC and Threonine:Lysin ratio (Thr: Lys on the productive yields, an experiment during 28 days was made. 42 pigs of approximately 72,4± 2,3 kg were used in which the effect of two levels of RAC was evaluated (5 and 10 ppm and three relate Thr:Lys (0,60; 0,65 and 0,70 in the diet on the consumption of daily food (CDF, the daily weight gain (DWG, daily lean fat-free tissue gain (DLFFTG, and also, the efficiency (Ef was expressed as DLFFTG in function of CDF. A randomized

  14. Perfil clínico epidemiológico de los pacientes con cáncer tratados en una institución de tercer nivel. Manizales, Colombia, 1995-2004

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    Carlos Raúl Villegas; José Arnoby Chacón; Juan Paulo Cardona; Luz Ángela Correa

    2012-01-01

    Antecedentes: Los diagnósticos de cáncer son cada vez mayores y ello está asociado con el aumento de la expectativa de vida, la exposición a carcinógenos, la cobertura en salud, el tamizaje y la búsqueda activa de casos. En Estados Unidos se diagnostican 1’000,000 de casos nuevos y más de 500,000 muertes por año. Los costos de laatención y la incapacidad laboral son muy altos. En Colombia, el patrón de ocurrencia de esta enfermedad se constituye en un problema de salud pública. En Manizales, ...

  15. La Alianza Bolivariana para las Américas-Tratado de Comercio de los Pueblos (ALBA-TCP: análisis de un proyecto de integración regional latinoamericana con una fuerte dimensión altermundialista.

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    Francisco Javier Ullán de la Rosa

    2011-11-01

    Full Text Available El ALBA-TCP es una de las organizaciones internacionales de más reciente creación. Es, sin duda, un proyecto original, diferente a las fórmulas de integración regional conocidas y preexistentes: fuertemente dirigido desde lo político, se propone como un mecanismo para planificar desde lo público las relaciones económicas y comerciales entre países, evitando o reduciendo en lo posible la competencia de mercado y fomentando la cooperación y las sinergias desde valores socialistas y de solidaridad. Y todo esto como expresión de una encrucijada ideológica donde crecen y se mezclan, con la lógica del collage posmoderno, casi todas las corrientes del pensamiento social de izquierda. El ALBA y los gobiernos que lo integran se encuentran en medio de una confrontación geopolítica e ideológica de escala continental que sesga enormemente la objetividad de los análisis. Este artículo pretende superar dichos sesgos presentando un análisis académico riguroso y sin toma de partido alguno. En él se analizan las circunstancias históricas que envuelven el nacimiento y evolución del ALBA y se incursiona en el análisis de su programa ideológico y sus proyectos concretos, señalando su convergencia con los del movimiento altermundialista latinoamericano y mundial. Por último, se apuntan algunas estadísticas de desarrollo concretas a fin de valorar los resultados en la práctica de las políticas económicas de este bloque regional.

  16. Velocidad de la onda de pulso y la excreción urinaria de albumina en pacientes hipertensos tratados con Perindopril Pulse wave velocity and urinary albumin excretion in hypertensive patients treated with perindopril

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    J. E. Tobilli

    2002-12-01

    Full Text Available La presión arterial sistólica, la presión arterial diastólica y la excreción urinaria de albúmina (EUA han sido reconocidas como predictores de riesgo cardiovascular. Además, los trastornos de la compliance arterial (CA evaluados mediante la velocidad de la onda de pulso elevada (VOP están estrechamente relacionados con los cambios de la presión arterial y correlacionados con la mortalidad cardiovascular y la presencia de ateroesclerosis. El objetivo primario de este estudio ha sido determinar la relación entre la VOP y la EUA en un grupo de pacientes no fumadores con hipertensión esencial y secundariamente evaluar los cambios producidos por un inhibidor de la enzima convertidora de angiotensina (perindopril sobre estas dos variables. En el estudio participaron setenta pacientes (33 hombres y 37 mujeres hipertensos no fumadores, sin tratamiento previo, de 50 ± 7 años (entre 35-69. La VOP de todos los pacientes fue estudiada por medio de un dispositivo computarizado (Complior en el período basal y a los seis meses de tratamiento con perindopril. También se determinó la EUA por el método de inmunodifusión radial al inicio del tratamiento y luego de seis meses de tratamiento con perindopril (4.6 ± 1.4 mg/día. Al finalizar el estudio se observó una reducción significativa de la presión arterial sistólica (PAS (160.2 ± 10.6 vs. 131.9 ± 7.1 mmHg, pSystolic and diastolic blood pressures and urinary albumin excretion (UAE have been recognized as predictors for cardiovascular risk. Furthermore, arterial compliance (AC disorders assessed by increased aortic pulse wave velocity (PWV are closely related to changes in blood pressure and strongly correlated with cardiovascular mortality and presence or extent of atherosclerosis. Our purpose in the present study was to determine a relationship between AC using PWV and UAE in a group of non-smoking patients with essential hypertension, and the level of interaction of ACE inhibition on

  17. El Tratado De Dilectione Dei de Balduino de Ford

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    Carlos Hallet

    2004-01-01

    Full Text Available Figura relevante de la Orden del Císter, Balduino de Ford es un autor que se distingue por la originalidad de su espiritualidad. Su tratado De dilectione Dei es una meditación sobre el Primer Mandamiento, que nos invita a amar a Dios "con todo el corazón en sus beneficios, con toda el alma en sus promesas, con todas las fuerzas en sus juicios y con toda la mente en sus preceptos". Su reflexión, nutrida de la Biblia y expresada en un lenguaje marcado por la retórica latina, insiste en que el amor perfecto exige del creyente amar lo que a Dios le agrada porque a Él le agrada. Termina identificando prácticamente amor con obedienciaFamous figure of the cistercian order, Baldwin of Ford is an author who stands out for the originality of his spirituality. His treatise "De dilectione Dei" is a meditation about the First Comandment, which is an invitation to love God "with all the heart in His benefits, with all the soul in His promises, with all the forces in His judgements and with all the mind in His precepts". According to his reflection, fed with the Bible and expressed in a language marked by the latin rhetoric, the perfect love requires to love what is pleasing to God because it pleases Him. Baldwin practically identifies love with obedience

  18. Fall-related injuries among youth under 20 years old who were treated in Nicaraguan emergency departments, 2004 Lesiones relacionadas con caídas en menores de 20 años de edad que fueron tratados en departamentos de emergencias de Nicaragua, 2004

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    María de Lourdes Martínez-Trujillo

    2011-04-01

    Full Text Available OBJECTIVE: To describe the circumstances of fall-related injuries among youth 0-19 years treated in emergency departments in Nicaragua; to estimate the incidence rates (IR of falls; and, to identify areas for prevention efforts. MATERIAL AND METHODS: All patients OBJETIVO: Describir las lesiones relacionadas con caídas entre los niños y adolescentes menores de 20 años de edad que fueron tratados en departamentos de emergencia de Nicaragua, 2004. Describir las circunstancias y estimar la tasa de incidencia (TI de las caídas entre niños y adolescentes de 0-19 años atendidos en las salas de emergencia en Nicaragua. Además, identificar áreas dónde dirigir los esfuerzos de prevención. MATERIALES Y MÉTODOS: Se seleccionaron todos los pacientes (6593 de 0-19 años lesionados por caídas atendidos en emergencia por el Sistema de Vigilancia de Lesiones en 2004 en las ciudades de Managua, León, Jinotepe y Ciudad Sandino. RESULTADOS: En 2004, la TI para caídas en niños y adolescentes 0-19 años fue 104.2 por 10000 habitantes. La TI en varones fue dos veces más alta que en mujeres. Los principales objetos involucrados fueron árboles (23.3% y camas (15.2%. La principal naturaleza de lesión fue fractura (35.7%. CONCLUSIONES: Mobiliario, lugares de recreación y ambiente físico fueron las áreas identificadas. Desarrollar intervenciones incluyendo cambios en el ambiente del hogar y áreas recreacionales, así como programas educacionales, resulta muy útil para adolescentes y cuidadores.

  19. El tratado de Derecho Administrativo del Profesor Rodolfo Carlos Barra

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    Daniel Hugo Martins

    2014-06-01

    Full Text Available En el "Tratado" cuyos primeros dos tomos han sido públicados recientemente, Barra se propone aplicar la "tesis cuatripartita" al derecho administrativo, con base en la "filosofía perenne" y la interpretación tomista del derecho."Este trabajo -dice- propugna la sistematización y mediatización del Derecho Administrativo, como rama del derecho público que garantiza el cumplimiento del acto justo en las relaciones de justicia distributiva y está referido a la regulación de la relación jurídica Estado (Administración Pública - administrado"

  20. Asociaciones verbales en esquizofrénicos tratados con olanzapina frente a los tratados con neurolépticos convencionales

    OpenAIRE

    Basilia Guerra Amador; María Pilar Jiménez Sánchez; José Luis Fernández Trespalacios; María del Prado Rivero Expósito

    2002-01-01

    En estudios anteriores se ha comprobado que los sujetos esquizofrénicos presentan mayor índice de comunalidad y mayor índice de respuestas únicas que los sujetos normales en el test de asociaciones verbales de Kent-Rosanoff. Estos resultados, interpretados como una mayor estereotipia y menor nivel de integración en el grupo, nos llevarían a poder delimitar un aspecto de anormalidad en el funcionamiento cognitivo de algunos pacientes esquizofrénicos. Por otra part...

  1. Comportamiento de los niveles plasmáticos de la sustancia p (sp) y de beta-endorfinas, en pacientes con migraña tratados con acupuntura vs. sumatriptan + propranolol / Behavior of plasma levels of substance p (sp) and beta-endorphins in patients with migraine treated with acupuncture vs sumatriptan + propranolol

    OpenAIRE

    Ávila Vera, Carlos Arturo

    2009-01-01

    El abordaje terapéutico de la migraña incluye herramientas farmacológicas que aunque han demostrado efectividad, también se asocian con una gran variedad de efectos adversos. En los últimos años, ha habido un auge creciente en el uso de la acupuntura para tratar esta molestia con resultados satisfactorios, pero la comunidad científica es renuente a aceptar esta terapéutica como una herramienta útil aduciendo que, aunque existen diversos estudios clínicos que señalan que la acupuntura es efect...

  2. LAS INSTITUCIONES DE LOS TRATADOS ESTABLECIDAS EN LA CONSTITUCIÓN MEXICANA

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    Olguín-Torres, Antonio

    2015-01-01

    Derivado de la reforma constitucional de junio del 2011 y el resurgimiento de la importancia de los tratados en el sistema jurídico mexicano, se analizan los artículos 76 fracción I y 89 fracción X de la Constitución Política de los Estados Unidos Mexicanos en lo relacionado con las figuras del derecho internacional ampliamente desarrolladas en la doctrina como: terminación, denuncia, suspensión, modificación, enmienda, declaración interpretativa y reservas, con la finalidad de precisar tanto...

  3. Malformación arteriovenosa pulmonar: Características clínicas, diagnóstico y rol del tratamiento quirúrgico en pacientes tratados con cirugía resectiva pulmonar Pulmonary arteriovenous malformation: Clinical features, diagnosis and role of surgical management in patients with lung resection surgery

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    ROBERTO GONZÁLEZ L

    2011-03-01

    Full Text Available Introducción: Las malformaciones arteriovenosas pulmonares (MAVP son infrecuentes y la cirugía tiene un rol en casos seleccionados. Objetivos: Describir las características clínicas, métodos diagnósticos y rol del tratamiento quirúrgico en pacientes tratados con cirugía por MAVP. Materialy Método: Revisión retrospectiva, incluyendo todos los pacientes con diagnóstico de MAVP en quienes se realizó cirugía en el Instituto Nacional del Tórax, desde febrero de 2005 a febrero de 2010. El seguimiento fue por control médico o contacto telefónico. Resultados: Se analizó 8 pacientes, seis mujeres (relación 3:1, edad entre 16 y 68 años. Los síntomas y signos más frecuentes fueron: disnea, cianosis y acropaquia. La localización más frecuente fue el lóbulo inferior derecho. Cuatro pacientes tenían MAVP múltiples y cuatro cumplían con criterios de Enfermedad de Rendu-Osler-Weber Seis tenían policitemia y dos anemia. La radiografía fue anormal en todos los casos y la tomogrqfía computada definió la anatomía en siete. Angiogrqfia se realizó en tres casos. Dos tenían ecocardiograma con contraste y cuatro cintigrama. La cirugía más frecuente fue la lobectomía. La indicación de cirugía fue: tamaño de la MAVP en cinco, falla de embolización en dos y hallazgo intra operatorio en uno, intervenido por otra razón. Uno presentó hemorragia post-operatoria. La estadía post-operatoria fue entre 2 y 10 días. No hubo mortalidad. En el último control todos los pacientes estaban asintomáticos. Conclusión: Las MAVPpueden presentarse en un amplio espectro clínico y anatómico. Pueden generar síntomas y complicaciones graves, por esto se recomienda tratarlas. El estudio pre-operatorio se basa en demostrar el shunt y en determinar las características anatómicas de la lesión. En algunos casos seleccionados está indicada la cirugía resectiva pulmonar.Background: Pulmonary arteriovenous malformations (PA VM are rare and surgery

  4. Posesión, retención y uso de mosquiteros tratados con insecticidas de larga duración luego de un año de su distribución en Loreto, Perú Long-lasting insecticide - treated bednet ownership, retention and usage one year after their distribution in Loreto, Peru

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    Angel Rosas-Aguirre

    2011-06-01

    Full Text Available Objetivos. Evaluar la posesión, retención y uso de mosquiteros tratados con insecticida de larga duración (MTILD luego de un año de su distribución en Loreto, Perú. Materiales y métodos. De julio a septiembre de 2007 se distribuyeron 26 185 MTILD Olyset Net® en 194 comunidades objetivo de Loreto, que protegieron a 45 331 personas. Posteriormente, se realizaron visitas de monitoreo (primera en diciembre de 2007 y segunda en julio de 2008 a los hogares de una muestra de 60 comunidades objetivo (30,9% del total, colectándose mediante un cuestionario semiestructurado los datos necesarios para el cálculo de indicadores de posesión, retención y uso de los MTILD. Resultados. En ambas visitas, la posesión de MTILD en hogares fue elevada (99,9% y 98,7%, respectivamente. La razón MTILD/persona disminuyó de 0,58 al momento de la distribución a 0,51 en la segunda visita, estimándose una retención al año de MTILD de 87%. En la primera visita, 99,0% de los niños Objectives. To assess long-lasting insecticide - treated bednet (LLITN ownership, retention and usage one year after their distribution in Loreto, Peru. Materials and methods. From July to September 2007, 26,185 LLITNs Olyset Net ® were delivered in 194 targeted communities in the Peruvian Amazon region, covering 45,331 people. Two cross-sectional community-based surveys in December 2007 and July 2008 were undertaken in a sample of 60 targeted communities (30.9% out of the total. A semi-structured questionnaire was used to collect necessary data to calculate LLITN ownership, retention and usage indicators. Results. High LLITN household ownership was showed in both surveys (99.9% and 98.7%, respectively. LLITN/ person ratio decreased from 0.58 at the end of the LLITN delivery to 0.51 in the second survey, estimating LLITN retention of 87% after 1 year of intervention. In the first survey, 99.0% of all children <5 years and 96,0% of pregnant women slept under a LLITN the previous

  5. Patterns of extension of gastrointestinal stromal tumors (GIST treated with imatinib (Gleevec® by 18F-FDG PET/CT Patrones de extensión de los tumores del estroma gastrointestinal (GIST tratados con imatinib (Gleevec® mediante PET/TC con 18F-FDG

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    Eulalia Valls-Ferrusola

    2012-07-01

    Full Text Available Background and aim: currently it is recognized the usefulness of 18F-FDG PET in assessing response to therapy with imatinib (Gleevec® in the gastrointestinal tract sarcomas (GIST. To facilitate the follow-up of these studies is important to know the patterns of metastatic spread. The aim of this paper is to describe patterns observed in the 18F-FDG PET/CT. Method: retrospective study included 29 patients who underwent 18F-FDG PET/CT after being diagnosed with unresectable or metastatic GIST. In total, 87 PET/CT studies were performed (1-6 controls per patient with a mean time of follow-up 6-36 months. We analyzed the location of the lesions evidenced in PET, CT and fusion. Images were evaluated visually and semiquantitatively (SUV. In cases in which has been considered necessary, additional images have been undertaken: PET delayed imaging, intravenous contrast CT and inspiratory chest CT. Results: the most common primary site was the stomach (41%, small bowel (35%, and rectum (24%. Significant changes in the location of metastatic disease between pre-treatment and the monitoring were observed, with the appearance of more extra-abdominal disease. Conclusions: individualization of protocol studies and interpretation of PET, CT and fused images were required for evaluation of treatment response to imatinib. Hybrid 18F-FDG PET/CT provides an accurate determination of the extent of GIST. While the most common metastatic site is the liver and peritoneum, in the following cases are common extra-abdominal disease.Introducción y objetivo: actualmente está reconocida la utilidad de la 18F-FDG-PET en la evaluación de la respuesta a la terapia con imatinib (Gleevec® en los sarcomas del tracto gastrointestinal (GIST. Para facilitar la valoración comparativa de estos estudios es importante conocer sus patrones de diseminación metastásica. El objetivo de este trabajo es describir estos patrones evidenciados en la 18F-FDG-PET/TC. Método: estudio

  6. Control Sitophilus zeamais (Coleoptera: Curculionidae in Maize (Zea mays L. treated with diatomaceous eart Coltrol de Sitophilus zeamais (Coleoptera: Curculionidae en maíz (Zea mays L. tratados con tierra de diatomeas Controle de Sitophilus zeamais (Coleoptera: Curculionidae em milho (Zea mays L. tratado com terra de diatomácea

    Directory of Open Access Journals (Sweden)

    Juliana Neitzke

    2010-04-01

    ácea (TD, na proporção de zero, 50, 100, 150, 200, 250 g de TD t-1, todos acondicionados em copos de plástico de 250 mL. Em cada copo plástico foram liberados 20 insetos de S. zeamais e estes fechados com tecido de “nylon” de malha fina, para a aeração. As avaliações da mortalidade dos insetos foram realizadas aos 3, 6 e 9 dias após a infestação (DAI, através da contagem em bandejas dos insetos mortos e vivos, e da possível reinfestação. O tratamento com terra diatomácea em milho (Zea mays na dosagem de 250 g t-1 proporcionou melhor controle de S. zeamais.

    El maíz (Zea mays L. es uno de los cereales más importantes cultivadas en todo el mundo. Como el producto se vende al natural, la principal preocupación es mantener la calidad del grano, pero su almacenamiento es difícil debido a la amplia gama de plagas que pueden atacar, causando reducción de calidad. El objetivo de este estudio fue evaluar diferentes dosis de tierra de diatomeas (TD en la mortalidad del gorgojo del maíz (Sitophilus zeamais en granos del maíz almacenado y comprobar el tiempo de exposición de cada tratamiento. El diseño experimental fue completamente aleatorizado con seis tratamientos y cinco repeticiones. Los tratamientos consistieron en aumentos en las dosis de TD en una proporción de cero, 50, 100, 150, 200, 250 g de TD t-1, todo ello incluido en vasos de plástico de 250 mL. En cada vaso de plástico fue puesto en libertad 20 insectos de S. zeamais y cerrada con malla de tela fina de nylon para la aireación. Las evaluaciones de la mortalidad de insectos se realizaron los días 3, 6 y 9 después de la infestación (DAI, con la cuenta en las bandejas de insectos vivos y muertos, y de la reinfestación posible. El tratamiento con tierra de diatomeas en el maíz en dosis de 250 g de TD t-1 resultó en un mejor control de S. zeamais.

  7. Neoliberalismo y Tratado de Libre Comercio: ¿hacia ciclos de guerra civil?

    Directory of Open Access Journals (Sweden)

    John Saxe-Fernández

    1999-12-01

    Full Text Available El tratado de libre comercio TLC, es la formalización de una relación subordinada de México con Estados Unidos. El aperturismo mexicano ha sido marcado con mayor énfasis por los gobiernos de Porfirio Díaz y de Carlos Salinas de Gortari. El modelo económico derivado ha provocado la desviación de inversión pública al gasto no productivo, como el pago del servicio de la deuda, la liberación de precios junto al control salarial para reducir la inflación, con el propósito de "aumentar competitividad internacional" de los productos mexicanos de exportación.

  8. Tratamiento y seguimiento en pacientes con leucemia mieloide crónica en el hemocentro - UNICAMP (Brasil

    Directory of Open Access Journals (Sweden)

    E. Miranda

    2006-04-01

    Full Text Available Relatar la experiencia del Hemocentro Unicamp en el tratamiento y seguimiento de los pacientes con leucemia mieloide crónica (LMC tratados con mesilato de imatinib y la experiencia en transplantes alogénico.

  9. Tratamiento y seguimiento en pacientes con leucemia mieloide crónica en el hemocentro - UNICAMP (Brasil)

    OpenAIRE

    Miranda, E.; M. Torresan Delamain; I. Lorand Metze; A. C. Vigorito; K. B. Pagnano; Souza, C.A.

    2006-01-01

    Relatar la experiencia del Hemocentro Unicamp en el tratamiento y seguimiento de los pacientes con leucemia mieloide crónica (LMC) tratados con mesilato de imatinib y la experiencia en transplantes alogénico.

  10. Efectos de las formulaciones de citronelal ozonizado en el tratamiento de conejos con Dermatomicosis

    Directory of Open Access Journals (Sweden)

    Kendra García Madan

    2010-01-01

    Full Text Available El citronelal ozonizado presenta propiedades antimicrobianas y antifúngicas contra diferentes microorganismos. El objetivo de este estudio fue investigar el efecto de tres formulaciones, al 1, 3 y 5% de citronelal ozonizado y una formulación placebo, comparadas con el OLEOZON Tópico en la Dermatomicosis de conejos. En este estudio se utilizaron 27 conejos blancos de la raza Nueva Zelanda, distribuidos en 6 grupos de la siguiente forma: Grupo I, conejos sin tratamiento; Grupo II, tratados con OLEOZON Tópico; Grupo III, tratados con la formulación 1 (citronelal ozonizado al 3%; Grupo IV, tratados con la formulación 2 (citronelal puro al 5%; Grupo V, tratados con la formulación 3 (citronelal ozonizado al 5% y Grupo VI, tratados con la formulación 4 (citronelal ozonizado al 1%. El diagnóstico de la enfermedad se realizó por inspección visual y raspado profundo y cultivo. Todos los tratamientos se aplicaron tópicamente en días alternos durante 15 días. Como resultado, los animales de los grupos II Y III se curaron en los 15 días, Sin embargo los conejos del grupo II mostraron la piel aceitosa por una semana después de concluido el estudio. La apariencia de la piel sana de los conejos tratados con la formulación al 3% fue mejor en comparación con el grupo tratado con OLEOZON. El resto de los grupos, tratados con las formulaciones al 1 y 3% y con la formulación placebo, no se curaron con los 15 días de tratamiento. Este estudio demuestra la alta efectividad terapéutica de la formulación de citronelal ozonizado al 3% en el tratamiento de la dermatomicosis en conejos.

  11. Introducción. El compromiso con los derechos fundamentales.

    OpenAIRE

    Mangas, Araceli

    2016-01-01

    Se analiza el carácter y la evolución de la protección de los derechos fundamentales en la UE, desde el silencio de los Tratados fundacionales, la protección judicial y la inclusión de la obligación en lso Tratados y en la Carta de Niza, las tensiones con las cortes constitucionales de los Estados miembros y la situación de plena protección tras el Tratado de Lisboa.

  12. Introducción. El compromiso con los derechos fundamentales.

    OpenAIRE

    Mangas, Araceli

    2008-01-01

    Se analiza el carácter y la evolución de la protección de los derechos fundamentales en la UE, desde el silencio de los Tratados fundacionales, la protección judicial y la inclusión de la obligación en lso Tratados y en la Carta de Niza, las tensiones con las cortes constitucionales de los Estados miembros y la situación de plena protección tras el Tratado de Lisboa.

  13. Esquistossomose: 1.000 pacientes tratados

    Directory of Open Access Journals (Sweden)

    Pedro Aquino Noleto

    1974-12-01

    Full Text Available Os autores relatam sua experiência com o hycanthone em 1.000 pacientes de esquistossomose mansônica, até agora tratados no Hospital de Clínicas da Universidade do Estado da Guanabara. São pacientes oriundos de áreas endêmicas do País, especialmente do nordeste e sudeste, 53,9% do sexo masculino e 46,1% do sexo feminino, de idade entre 5 e 63 anos. A forma clínica predominante da parasitose foi a hépato-intestinal (96,8%. O medicamento foi administrado em dose única, na razão de 3 mg/kg de peso corporal, a 33.6% de pacientes internados e a 66 4% em regime de tratamento ambulatorial. Os níveis séricos das transaminases, determinados, para confronto, antes e depois do uso do produto, em 60 dos pacientes internados, não se alteraram, ou apenas sofreram elevações inexpressivas. Não houve efeitos colateriais em 42,3% dos pacientes. Nos demais, esses efeitos foram de pequena e média intentidade, duraram apenas o 19 dia, na maioria das vezes, e consisfram, especialmente, de náuseas e de vômitos. O controle de cura parasitária estabelecido compreendeu 4 exames de fezes - aos 30, 60, 90 e 120 dias do emprego do medicamento, o que já se fez em 330 pacientes (33%, com 99% de cura. Incluída a biópsia retal, sempre que foi possivel, por ocasião do 4º exame de fezes, o esquema funcionou até agora em 97 pacientes (9,7%, dos quais 92 (94% estão curados, segundo esse critério. O presente trabalho confirma a ação esquistossomicida do hycanthone, bem como sua boa tolerabilidade, inclusive no que se refere ao hepatócito. Os doentes, entretanto, devem ser criteriosamente selecionados, tendo-se em vista as contra-indicações conhecidas, de modo especial em relação ao fígado.

  14. MERCOSUL E DIREITOS HUMANOS NO QUADRO DO CONFLITO ENTRE A CONSTITUIÇÃO BRASILEIRA E OS TRATADOS INTERNACIONAIS

    OpenAIRE

    Ana Paula Barbosa-Fohrmann

    2010-01-01

    I - Introdução; II - Um Panorama do Conflito de Fontes; 1. Lei Interna e Tratado Internacional; 1.1. A Posição da Doutrina; 1.2. A Posição do Supremo Tribunal Federal; 2. Constituição e Tratado Internacional; 2.1. Visão Normativa e Predominante; 2.2. Visão Moral e Alternativa; III - O Direito Constitucional e a sua Relação com o Direito da Integração e os Direitos Humanos; 1 - Direito da Integração: O MERCOSUL; 2 - A Questão do Conflito de Fontes no MERCOSUL; 3 - Os Direitos Humanos; IV - Con...

  15. Estudio del perfil del paciente tratado en la asignatura de prótesis estomatológica II en la Facultad de Odontología de Sevilla durante el período 2001-2011 y su relación con las competencias del título de graduado en odontología.

    OpenAIRE

    Arroyo Cruz, Gema

    2014-01-01

    Con esta breve introducción me gustaría transmitir cómo surgió en mí la inquietud por este trabajo. Toda mi vida universitaria ha estado ligada a la disciplina de Prótesis, primero como alumna interna, después como colaboradora y finalmente como docente. Esto me ha permitido estar presente y conocer de primera mano cómo se ha ido impartiendo la asignatura, qué cambios han acontecido y formarme con ello una opinión al respecto. Pero observar no siempre nos permite obtener una información preci...

  16. Replicación viral y producción de óxido nítrico y malondialdehído en cultivos celulares y ratones tratados preventivamente con melatonina, minociclina y ácido ascórbico infectados por el virus de encefalitis equina venezolana

    OpenAIRE

    Salazar de Acosta, Jenny

    2011-01-01

    El virus de Encefalitis Equina Venezolana (EEV) ha causado extensas epidemias a lo largo de América del Sur, sobre todo en Venezuela. Afecta, con una alta morbilidad, el sistema nervioso central (SNC) en humanos y equinos. Existen sustancias antioxidantes que interactúan con los radicales libres retardando la oxidación; entre ellas se encuentran la Melatonina (MLT), la Minociclina (MIN) y el Ácido ascórbico (AA). Se plantea determinar el efecto in vitro e in vivo de la MLT, MIN y AA sobre la ...

  17. Los tratados de libre comercio: instrumentos para controlar la biodiversidad

    OpenAIRE

    Rodríguez Cervantes, Silvia

    2013-01-01

    La soberanía de cada Estado para regular la Bioprospección y utilización de la biodiversidad contenida en sus fronteras, fue un derecho reforzado por el Convenio de Diversidad Biológica de 1994 y diez años más tarde por el Tratado conocido como Tratado de la Semilla. Sin embargo, sus alcances se han visto obstaculizados por diversos pactos comerciales y sus respectivas políticas de propiedad intelectual. Algunos son de carácter multilateral; otros son re...

  18. Characterization and Fine Mapping of a Novel Rice Albino Mutant low temperature albino 1

    Institute of Scientific and Technical Information of China (English)

    Yu Peng; Sheng Teng; Yi Zhang; Jun Lv; Jianhui Zhang; Ping Li; Xiaoliang Shi; Yufeng Wang; Honglei Zhang; Zuhua He

    2012-01-01

    Albino mutants are useful genetic resource for studying chlorophyll biosynthesis and chloroplast development and cloning genes involved in these processes in plants.Here we report a novel rice mutant low temperature albino I (ltal) that showed albino leaves before 4-leaf stage when grown under temperature lower than 20℃,but developed normal green leaves under temperature higher than 24℃ or similar morphological phenotypes in dark as did the wild-type (WT).Our analysis showed that the contents of chlorophylls and chlorophyll precursors were remarkably decreased in the ltal mutant under low temperature compared to WT.Transmission electron microscope observation revealed that chloroplasts were defectively developed in the albino ltal leaves,which lacked of well-stacked granum and contained less stroma lamellae.These results suggested that the ltal mutation may delay the light-induced thylakoid assembly under low temperature.Genetic analysis indicated that the albino phenotype was controlled by a single recessive locus.Through map-based approach,we finally located the Ltal gene to a region of 40.3 kb on the short arm of chromosome 11.There are 8 predicted open reading frames (ORFs) in this region and two of them were deleted in ltal genome compared with the WT genome.The further characterization of the Ltal gene would provide a good approach to uncover the novel molecular mechanisms involved in chloroplast development under low temperature stress.

  19. LOS TRATADOS INTERNACIONALES SOBRE DERECHOS HUMANOS Y SU UBICACIÓN EN EL ORDEN NORMATIVO INTERNO

    Directory of Open Access Journals (Sweden)

    Emilio Pfeffer Urquiaga

    2003-01-01

    Full Text Available El artículo analiza la precariedad de la normativa constitucional chilena en materia de incorporación del derecho convencional internacional, tanto en común como específicamente en materia de derechos humanos, pronunciándose sobre la jerarquía de los tratados que contienen derechos humanos de acuerdo con la doctrina y la jurisprudencia, abogando por un pronto desarrollo de normas constitucionales al efecto.This work highlights the precariousness of Chilean Constitutional Law with respect to the incorporation of international conventional Law, both in general and specifically in the area of human rights. The status accorded to human rights treaties by legal scholarship and judicial decisions is examined, and advocacy is advanced for further development of constitutional norms on the matter of incorporation of international treaties on human rights.

  20. Fracturas por fatiga del cuello femoral: A propósito de un caso tratado quirúrgicamente

    OpenAIRE

    Arenas Planelles, Antonio; Arias Nieto, C.; Eslava Echavarren, E.; Tejero Ibáñez, Alberto; Garbayo Marturet, Antonio Jesús; Pablos Fernández, Julio de

    2000-01-01

    Se presenta un caso de fractura por fatiga de cuello femoral en un paciente de 26 años. Fue tratado quirúrgicamente realizándose osteosíntesis con 3 tornillos. La evolución fue satisfactoria, encontrándose el paciente sin dolor ni repercusión funcional a los 4 años de la lesión. A case of stress fracture of the femoral neck in a 26-year-old patient is presented. Surgical treatment was indicated by means of internal fixation with three screws. At four-year follow-up there was no pain or fun...

  1. How does agonistic behaviour differ in albino and pigmented fish?

    Science.gov (United States)

    Slavík, Ondřej; Horký, Pavel; Wackermannová, Marie

    2016-01-01

    In addition to hypopigmentation of the skin and red iris colouration, albino animals also display distinct physiological and behavioural alterations. However, information on the social interactions of albino animals is rare and has mostly been limited to specially bred strains of albino rodents and animals from unique environments in caves. Differentiating between the effects of albinism and domestication on behaviour in rodents can be difficult, and social behaviour in cave fish changes according to species-specific adaptations to conditions of permanent darkness. The agonistic behaviours of albino offspring of pigmented parents have yet to be described. In this study, we observed agonistic behaviour in albino and pigmented juvenile Silurus glanis catfish. We found that the total number of aggressive interactions was lower in albinos than in pigmented catfish. The distance between conspecifics was also analysed, and albinos showed a tendency towards greater separation from their same-coloured conspecifics compared with pigmented catfish. These results demonstrate that albinism can be associated with lower aggressiveness and with reduced shoaling behaviour preference, as demonstrated by a tendency towards greater separation of albinos from conspecifics. PMID:27114883

  2. Pretextos y contextos olvidados : arte, ciencia y técnica en algunos tratados contables de la Inglaterra Tudor

    Directory of Open Access Journals (Sweden)

    Juan Lanero Fernández

    2009-06-01

    Full Text Available El presente estudio pretende ver, desde una perspectiva amplia, los dos tratados de James Peele (1553, 1569. The pathe waye (1569, en su conjunto, se aparta de forma considerable de los tratados publicados con anterioridad; y por lo que se refiere a su primer libro (1553, dispone de suficientes rasgos diferenciadores para que en el todo y en las partes sea una pieza bien distinta de tratados anteriores. Algunos detalles de The maner and fourme provienen directamente de Pacioli o a través del primer tratado inglés de partida doble, obra de Hugh Oldcastle (1543, o de Ympyn. La influencia de éste, por su tratado holandés/francés (1543 y la traducción inglesa (1547, se aprecia en The pathe waye en el cierre del Libro Mayor y en la forma que ambos tienen de tratar las operaciones de trueque. Es un hecho que Manzoni (1540 está presente en The moner and fourme en lo tocante a la numeración de las partidas en el Diario y a su referencia en el texto. Por lo que se refiere a la organización de los libros de cuentas, también existen resonancias de Weddington. La excelencia es la cualidad que destaca en los dos tratado, en particular en The pathe waye. Peele supo recoger en sus libros las tendencias más innovadoras de la partida doble provenientes de los autores que le precedieron. Está demostrado que Mellis manejó, aunque no siempre de forma apropiada, los tratados de Peele para su reedición de Oldcastle (1588. Y se puede decir lo mismo de John Carpenter (1632. Pele comprendió los verdaderos principios de la partida doble; pero sus excelentes tratados se quedaron injustamente olvidados en la penumbra de los pretextos, la competencia de los contextos y casi ningún paratexto que los valorara en su justiprecio que fue, y sigue siendo, elevado.The present paper tries to have a look, from a broad perspective, at James Peele's two treatises (1553, 1569. The pathe waye (1569, as a whole, drifts away considerably from the treatises previously

  3. La carga precoz de los implantes GMI con conexión interna y superficie arenada y grabada

    OpenAIRE

    E. Velasco Ortega; L. Monsalve Guil; N. Matos Garrido; A. Jiménez Guerra; A. García Méndez; R. Medel Soteras; I. Ortiz García; A. España López

    2014-01-01

    Introducción: La implantología oral representa en la actualidad, una modalidad terapéutica odontológica en los pacientes con pérdida dental total y parcial. El estudio muestra la evaluación de los pacientes tratados mediante carga precoz de implantes de titanio con conexión interna y superficie arenada y grabada. Métodos: 39 pacientes con pérdidas dentales fueron tratados con implantes con conexión interna y superficie arenada y grabada Frontier GMI®. Los implantes fueron cargados funcionalme...

  4. Expresión de cd34 en los blastos leucémicos como marcador pronóstico para muerte, recaída o falla de tratamiento en relación con la morfología monocítica de la leucemia mieloblástica aguda en pacientes tratados con quimioterapia “7x3” E HiDAC

    OpenAIRE

    Cárdenas Rodríguez, Yhonny Roberto

    2010-01-01

    Diferentes estudios in vitro y algunos escasos estudios clínicos han demostrado asociación entre la expresión de CD34 y resistencia a la apoptosis y múltiples medicamentos de quimioterapia, por lo que se hace muy importante la exploración clínica de esta variable como factor pronóstico en pacientes con Leucemia Mieloblástica Aguda y su posible modificación de efecto por parte de la morfología monocítica de algunas variedades de la enfermedad que tienen baja expresión conocida de CD34 (M5a y M...

  5. Influencia del marco regulatorio de los productos farmacéuticos en la salud pública. Análisis a partir de la ratificación por Colombia del Convenio ADPIC y de los Tratados de Libre Comercio con los Estados Unidos y la Unión Europea

    Directory of Open Access Journals (Sweden)

    Fernando Jiménez Valderrama

    2013-01-01

    Full Text Available Este artículo tiene por objetivo estudiar la relación entre la disponibilidad, los precios de los medicamentos y los intereses de salud pública. Para ello hemos utilizado una metodología de análisis de los intereses económicos implicados y también un método sistemático de tratamiento de la legislación nacional, comunitaria andina e internacional vigente. Igualmente hemos acudido a metodologías de derecho comparado entre nuestro ordenamiento jurídico nacional con los de otros países de mundo occidental. Existe un estrecho vínculo entre la disponibilidad y los precios de los medicamentos y los intereses de salud pública. Nuestro actual sistema legal reconoce a los inventores de nuevos medicamentos como un “monopolio” para negociar en el mercado farmacéutico. Para proteger los intereses públicos nuestra regulación establece algunos límites a los derechos de los inventores. Los derechos de propiedad se limitan en el tiempo y bajo algunas circunstancias es obligatorio autorizar a otros a usar la patente bajo un contrato de licenciamiento. La Organización Mundial del Comercio ha establecido (Decisión del Consejo de la OMC, Ronda Doha 2003 otros límites a estos derechos en caso de condiciones excepcionales. Nuestra Constitución Nacional otorga prevalencia a los intereses públicos sobre los privados. Es un deber de los gobiernos establecer un sistema justo en el cual los inventores puedan obtener una recompensa económica por sus creaciones y la sociedad pueda satisfacer sus necesidades de salud.

  6. Rescue of the albino phenotype by introducing a functional tyrosinase minigene into Kunming albino mice

    Institute of Scientific and Technical Information of China (English)

    Dong Xiao; Kang Xu; Xi-Gu Chen; Ying Yue; Xin-Yan Deng; Bing Huang; Zhong-Min Guo; Yun Ma; Yi-Li Lin; Xun Hong; Huan Tang

    2007-01-01

    AIM: To use the tyrosinase minigene as a visual marker to perform microinjection training and improve the techniques related with transgene to greatly elevate the efficiency of gene transfer.METHODS: A mouse tyrosinase minigene, i.e., TyBS,in which the 2.25-kb authentic genomic 5' non-coding flanking sequence of mouse tyrosinase was fused to a mouse tyrosinase cDNA, was introduced into the fertilized eggs of outbred Kunming albino mice.RESULTS: Of the 11 animals that developed from the injected eggs, two mice (P1 and #8) exhibited pigmented hair (P1) and eyes (P1 and #8), as confirmed by PCR analysis for the tyrosinase minigene integrated into the genome. When founder P1 was bred to Kunming male mouse, six progeny out of 11 offspring inherited the transgene and the pigmented-eye phenotype.CONCLUSION: Taken together, these results suggest that this minigene encodes the active tyrosinase protein and that its 5' flanking region contains the sequences regulating the expression of mouse tyrosinase gene as expected. We have rescued the albino phenotype by introduction and expression of a functional tyrosinase minigene in the Kunming albino mouse and the transgene can be passed to subsequent generation.These findings also indicate that TyBS can be a useful visual marker gene in the co-transgenic experiments.

  7. El Tratado de Asunción y el Mercosur

    Directory of Open Access Journals (Sweden)

    Miguel Berthet

    2015-10-01

    Full Text Available Texto de la conferencia pronunciada por el Embajador Dr. Miguel Berthet -Director de Relaciones Económicas Internacionales Y de Comercio Exterior de los Ministerios'de Relaciones Exteriores y de Economía y Finaszas- en nuestra Facultad. el 25 de abril de 1991, explicando el significado y alcance del Tratado de Asunción. ,suscrito pocos dias antes de esta exposición. La conferencia estuvo principalmente orientada a dar nociones básicas para los estudiantes

  8. Food Color Induced Hepatotoxicity in Swiss Albino Rats, Rattus norvegicus

    OpenAIRE

    Saxena, Beenam; Sharma, Shiv

    2015-01-01

    Objective: Certain dietary constituents can induce toxicity and play a critical role in the development of several hepatic disorders. Tartrazine, metanil yellow and sunset yellow are widely used azo dyes in food products, so the present study is aimed to investigate the food color induced hepatotoxicity in Swiss albino rats. Materials and Methods: Swiss albino rats were divided into four groups, each group having six animals. Group I served as control, Group II, Group III and Group IV were ad...

  9. ACUTE ORAL TOXICITY OF MUCUNA PRURIENS IN SWISS ALBINO MICE

    OpenAIRE

    Parekar Sushant Shahaji; Somkuwar Arju Parnu

    2011-01-01

    Mucuna pruriens, belonging to the botanical family Fabaceae, has been used in traditional Ayurvedic Indian medicine for various ailments including Parkinson’s disease. The current study reports the outcome of acute oral toxicity investigation of ethanolic extract of M. pruriens (whole plant) on Swiss albino mice. No mortalities or evidence of adverse effects have been observed in Swiss albino mice following acute oral administration of ethanolic extract of M. pruriens at the dose of 2000 mg/...

  10. El Tratado de hechicerías y sortilegios (1553) que "avisa y no emponzoña" de fray Andrés de Olmos

    OpenAIRE

    Ríos Castaño, Victoria

    2014-01-01

    En 1553 el franciscano e inquisidor fray Andrés de Olmos concluye el Tratado de hechicerías y sortilegios, una traducción al náhuatl del manual demonológico Tratado de las supersticiones y hechicerías, del también inquisidor fray Martín de Castañega, publicado en 1529. Los estudios que se han realizado al respecto se centran en el motivo por el cual Olmos elige esta obra y examinan brevemente las características de la traducción en comparación con el original. Este artículo pretende seguir co...

  11. Desinfección con ozono de los conductos radiculares tratados endodóncicamente

    OpenAIRE

    Lüdi Etchevarren, Viviana Clelia

    2016-01-01

    Este trabajo valora el efecto del ozono gas sobre células planctónicas y biopelículas maduras de E. faecalis, principal responsable de la persistencia de la infección periapical y el fracaso endodóncico. Se utilizaron dos equipos: uno de uso odontológico que proporciona una concentración máxima de ozono gas de 4 μg/mL, y otro de uso médico que consigue una concentración máxima de 80 μg/mL. Se utilizaron dos modelos experimentales. 1) Biopelículas de E. faecalis generadas experimentalmente ...

  12. SALES SOLUBLES Y METALES PESADOS EN SUELOS TRATADOS CON BIOSÓLIDOS

    OpenAIRE

    E. Robledo- Santoyo; V. Espinosa Hernández; R. Maldonado Torres; J. E. Rubiños Panta; E. Hernández Acosta; Ojeda Trejo, E.; L. Corlay Chee

    2010-01-01

    Las plantas de tratamientos de aguas residuales (PTAR) generan diariamente toneladas de lodos (biosólidos), los cuales pueden tener un uso agrícola como fuente de nutrientes y material mejorador del suelo, aunque también pueden ser fuente de contaminación por metales pesados y sales solubles. En este estudio se evaluó, en un suelo representativo de la zona de influencia de la PTAR de la ciudad de Aguascalientes, México, la aplicación de biosólidos y el efecto de su contenido de metales pesado...

  13. LOS DERECHOS HUMANOS Y LOS TRATADOS QUE LOS CONTIENEN EN EL DERECHO CONSTITUCIONAL Y LA JURISPRUDENCIA ARGENTINOS

    Directory of Open Access Journals (Sweden)

    Ricardo Haro

    2003-01-01

    Full Text Available 1. Atento al texto de la Constitución 1853/60, la Corte Suprema de Justicia sostuvo inveteradamente la supremacía de la Constitución sobre los tratados, como así también la paridad de jerarquía jurídica entre éstos y las leyes, salvo a partir de 1992 en que otorgó prioridad a los Tratados de Derechos Humanos (TT.DD.HH. sobre las Leyes. 2. Un cambio fundamental se produce en el orden jurídico argentino a partir de la Reforma Constitucional de 1994: a Se receptaron nuevos derechos y garantías; b Por el art. 75 inc. 22, se incorporaron con jerarquía constitucional diez TT. DD. HH., y se otorgó la primacía de los tratados sobre las leyes; c Por el art. 75 inc. 24 se prevé la posibilidad de tratados de integración que deleguen competencias y jurisdicción a organizaciones supraestatales; d La CS ha reconocido expresamente la jurisdicción de la Corte Interamericana de Derechos Humanos en la interpretación y aplicación de la Convención Americana y ha declarado que su jurisprudencia debe servir de guía para la interpretación de los preceptos convencionales.Under the provisions of the Argentine Constitution of 1853/60, the Supreme Court always maintained the doctrine of the supremacy of the Constitution over international treaties, and the status of these as equal to Congress' laws, until the Court gave precedence to treaties on human rights over national laws in 1992. A fundamental change takes place in Argentine law with the constitutional amendment of 1994: a new rights and guarantees were received; b By the provisions of article 75 subsection 22, ten treaties were given constitutional status, and treaties were granted precedence over national laws; c Article 75 subsection 24 authorizes the delegation of power and jurisdiction to supranational organizations under the provisions of integration treaties; d The Supreme Court has accepted the jurisdiction of the Inter-American Court of Human Rights over the interpretation and

  14. Implicaciones de la firma del Tratado de Libre Comercio entre Colombia y los Estados Unidos.

    Directory of Open Access Journals (Sweden)

    Olivier Guyottot

    2010-05-01

    Full Text Available Este artículo trata de mostrar que, más allá de su dimensión económica, el Tratado de Libre Comercio entre Estados Unidos y Colombia supone grandes retos políticos y geopolíticos para los dos países. En primera instancia, el TLC le permitiría a los Estados Unidos ampliar su red de acuerdos económicos bilaterales y constituye para Colombia una posibilidad de mejorar su presencia en el mercado norteamericano. Desde la perspectiva estadounidense, Colombia se convierte en un aliado y en un elemento crucial de influencia pro-norteamericana en Suramérica, en un contexto de inestabilidad; además de ser un apoyo en la lucha contra el terrorismo. Del lado colombiano, el Estado necesita la ayuda económica, financiera y logística de Estados Unidos para financiar su guerra contra el narcotráfico y los grupos armados. No obstante, el gobierno colombiano debe tener en cuenta los procesos regionales de integración económica, en los cuales está activamente involucrado, y favorecer las relaciones diplomáticas y comerciales con sus vecinos.

  15. El tratado de paz de los Pirineos : una revisión historiográfica (1888-1988)

    OpenAIRE

    Valladares Ramírez, Rafael Jesús

    1989-01-01

    Hace trescientos años y casi tres décadas se concluyó, en una isla del río Bidasoa, un tratado de paz —«perpetua», al decir de la época— entre las dos monarquías más poderosas de Europa. Con tales premisas, era de esperar que una concertación entre dos sistemas de fuerza (bélica y diplomática) tan considerables debía originar una tectónica de placas territoriales y políticas de no escasa relevancia. De entonces a esta parte, ningún autor que se haya aproximado al contencioso...

  16. Suscetibilidade aos agentes quimioterápicos de isolados de Schistosoma mansoni oriundos de pacientes tratados com oxamniquine e praziquantel e não curados

    Directory of Open Access Journals (Sweden)

    Neusa Araújo

    1996-10-01

    Full Text Available Foram estudados dez isolados de Schistosoma mansoni provenientes de pacientes residentes em Itaquara, Bahia, Brasil, tratados com oxamniquine eposteriormente com praziquantel, e ainda assim não curados. Caramujos (Biomphalaria glabrataj foram expostos a miracídios provenientes das fezes dos pacientes. Cercãrías eliminadas por estes caramujos e por moluscos coletados no peridomicílio dos pacientes foram utilizadas para infecção experimental de camundongos albinos. Os animais infectados foram tratados em dose única, via oral, com oxamniquine (25, 50 e 100 mg/kg ou praziquantel (100, 200 e 400mg/kg. Foram realizados estudos de análise e comparação de DNA de cercãrías de S. mansoni eliminadas pelos caramujos e de vermes adultos recolhidos de camundongos infectados experimentalmente com os isolados dos 10 pacientes e ainda de cercãrías de S. mansoni eliminadas por moluscos naturalmente infectados coletados em Itaquara. A cepa LE (mantida rotineiramente no laboratório foi usada como padrão de comparação da resposta aos agentes esquistossomicidas administrados. As respostas terapêuticas foram significativamente diferentes entre alguns dos isolados embora não fosse possível caracterizar nenhum como resistente. A análise dos perfis de amplificação de DNA nas cercãrías e nos vermes adultos dos isolados de S. mansoni demonstrou baixo grau de variabilidade indicando que estes são geneticamente próximos e revelando a ausência de rearranjos globais dentro dos genomas.

  17. The brainstem efferent acoustic chiasm in pigmented and albino rats.

    Science.gov (United States)

    Reuss, Stefan; Closhen-Gabrisch, Stefanie; Closhen, Christina

    2016-02-01

    The present study examined whether structural peculiarities in the brain-efferent pathway to the organ of Corti may underlie functional differences in hearing between pigmented and albino individuals of the same mammalian species. Pigmented Brown-Norway rats and albino Wistar rats received unilateral injections of an aqueous solution of the retrograde neuronal tracer Fluorogold (FG) into the scala tympani of the cochlea to identify olivocochlear neurons (OCN) in the brainstem superior olivary complex. After five days, brains were perfusion-fixed and brainstem sections were cut and analyzed with respect to retrogradely labeled neurons. Intrinsic neurons of the lateral system were located exclusively in the ipsilateral lateral superior olive (LSO) in both groups. Shell neurons surrounding the LSO and in periolivary regions, which made up only 5-8% of all OCN, were more often contralaterally located in albino than in pigmented animals. A striking difference was observed in the laterality of neurons of the medial olivocochlear (MOC) system, which provided more than one third of all OCN. These neurons, located in the rostral periolivary region and in the ventral nucleus of the trapezoid body, were observed contralateral to 45% in pigmented and to 68% in albino animals. Our study, the first to compare the origin of the olivocochlear bundle in pigmented and albino rats, provides evidence for differences in the crossing pattern of the olivocochlear pathway. These were found predominantly in the MOC system providing the direct efferent innervation of cochlear outer hair cells. Our findings may account for the alterations in auditory perception observed in albino mammals including man. PMID:26657095

  18. Los mecanismos de control de la aplicación y del cumplimiento de los tratados internacionales multilaterales de protección del medio ambiente

    OpenAIRE

    Borràs Pentinat, Susana

    2007-01-01

    LOS MECANISMOS DE CONTROL DE LA APLICACIÓN Y DEL CUMPLIMIENTO DE LOS TRATADOS INTERNACIONALES MULTILATERALES DE PROTECCIÓN DEL MEDIO AMBIENTETesis presentada para aspirar al título de Doctor/a en Derecho por:Susana BORRÀS PENTINATRealizada bajo la dirección del Dr. Antoni Pigrau SoléCatedrático de Derecho Internacional Público yRelaciones Internacionales 2007Abstract:The PhD thesis, entitled "Control Mechanisms on the implementation and compliance with Multilateral Environmental Treaties",con...

  19. Habla escénica en España : el siglo XIX y los tratados de declamación

    OpenAIRE

    Varona Peña, Antonio

    2015-01-01

    Resumen: Esta tesis ha permitido conocer la parte de la educación teatral vinculada al Habla Escénica (un arte con principios, procesos y reglas), sus contenidos, los métodos didácticos, y las formulaciones disciplinares progresivamente emancipadas de la retórica, la oratoria, el canto, y las tradiciones de la declamación. Presenta un estudio de la voz y el habla a través de los manuales y tratados de declamación del siglo XIX en España. Pone la atención en el papel de esta disciplina...

  20. CONTENIDO DE FENOLES TOTALES EN FRUTOS DE MANGO ′SUPER HADEN′ DAÑADOS POR ANTRACNOSIS Y TRATADOS EN POSCOSECHA

    OpenAIRE

    Akira Pérez Márquez; Yamile Vidal Aguiar; Tania Mulkay Vitón

    2016-01-01

    El contenido de fenoles totales en el exocarpio de los frutos tiene relación con los mecanismos de defensa propios del fruto frente al ataque por patógenos fúngicos. Colletotrichum gloeosporioides (Penz.) Penz. & Sacc. es causante de la antracnosis en el mango (Mangifera indica L.) y ocasiona elevadas pérdidas en poscosecha. El objetivo de este trabajo fue evaluar el contenido de fenoles totales en frutos de mango ‘Super Haden’ dañados y tratados en poscosecha y evi...

  1. Evaluation of analgesic activity of perindopril in albino mice

    OpenAIRE

    Suresha, R. N.; Siddamma Amoghimath; Vaibhavi, P. S.; Shruthi, S L; M.K. Jayanthi; H L Kalabharathi

    2014-01-01

    The aim was to evaluate the analgesic activity of perindopril in chemical, thermal and mechanical pain on Swiss albino mice. A total of 54 albino mice (Swiss strain) weighing 25-30 g were allocated to each experimental model and in each model there were three groups. The control group received normal saline (25 ml/kg) per orally, standard group received pentazocine (10 mg/kg) intra-peritoneal and test groups received perindopril (1 mg/kg) per orally. Perindopril and normal saline was administ...

  2. Perfil antropométrico en pacientes con psicosis que inician tratamiento con antipsicóticos: Estudio Ícaro

    OpenAIRE

    Herrero Pérez, Laura Julia

    2014-01-01

    Introducción. Los trastornos con psicosis tratados con antipsicóticos típicos o atípicos reflejan un aumento de la morbilidad por los efectos adversos secundarios del tratamiento. Entre estos efectos destacan los riesgos cardiovasculares y metabólicos asociados al aumento del peso corporal de la medicación. La población con un riesgo más alto de sufrir estas comorbilidades aumenta en sujetos con sobrepeso u obesidad previos al tratamiento con antipsicóticos. Objetivo princip...

  3. Effect of carbon monoxide on Swiss albino mice

    Science.gov (United States)

    Hilado, C. J.; Cumming, H. J.

    1977-01-01

    Times to incapacitation and death and LC50 values were determined for male Swiss albino mice exposed to different concentrations of carbon monoxide in a 4.2 liter hemispherical chamber. These values are compared to values reported in the literature. The LC50 for a 30 minute exposure was 3570 ppm CO.

  4. Differences in MITF gene expression and histology between albino and normal sea cucumbers ( Apostichopus japonicus Selenka)

    Science.gov (United States)

    Zhao, Heling; Yang, Hongsheng; Zhao, Huan; Liu, Shilin; Wang, Tianming

    2012-01-01

    Albino Apostichopus japonicus occur both in the wild and in captivity. The offspring of albino A. japonicus also suffer from albinism. The formation of melanin in the melanocytes is dependant on microphthalmia-associated transcription factor (MITF). To investigate the role of MITF in controlling albinism, we cloned the full-length MITF cDNA from A. japonicus and compared MITF mRNA expression in albino and normal A. japonicus. In addition, we used light and electron microscopy to compare histological samples of normal and albino A. japonicus. The body wall of albino adults was characterized by significantly lower levels of MITF expression and lower numbers of epidermal melanocytes, which also contained less melanin. In albino juvenile offspring, MITF expression levels were significantly lower 32 d after fertilization and there were fewer, and less developed, epidermal melanocytes. Thus, we conclude that albino A. japonicus have fewer melanocytes and a reduced ability to synthesize melanin, likely because of lower expression of MITF.

  5. Ventilación con liberación de presión en la vía aérea, en neonatos con insuficiencia respiratoria aguda

    OpenAIRE

    Emmanuel Jiménez-Castro; Olman Coronado-García; Leonardo Orozco-Saborio; Alicia Boza-Mora

    2013-01-01

    La ventilación con liberación de presión en la vía aérea (APRV)es una modalidad ventilatoria que utiliza presión positiva controlada en la vía aérea, con el fin de maximizar el reclutamiento alveolar, con tiempos inspiratorios prolongados, permitiendo la respiración espontánea durante ambas fases del ciclo respiratorio. Los autores describen su experiencia en una serie de 12 casos con pacientes neonatales con insuficiencia respiratoria aguda, que fueron tratados con la APRV ventilación con li...

  6. Evaluación económica de rituximab en combinación con fludarabina y ciclofosfamida en comparación con fludarabina y ciclofosfamida en el tratamiento de la leucemia linfática crónica Economic evaluation of rituximab added to fludarabine plus cyclophosphamide versus fludarabine plus cyclophosphamide for the treatment of chronic lymphocytic leukemia

    OpenAIRE

    Luis Felipe Casado; José Antonio García Marco; Florinda Gilsanz; Marcos González; Eduardo Ríos; Javier de la Serna; Álvaro Urbano; Vicente Vicente; Carlos Rubio-Terrés; Castro, Antonio J.

    2011-01-01

    Objetivos: Evaluar el coste-efectividad del esquema de rituximab, fludarabina y ciclofosfamida (R-FC) en comparación con el de fludarabina y ciclofosfamida (FC) en dos tipos de pacientes con leucemia linfática crónica (LLC): no tratados previamente o bien en recidiva/resistentes al tratamiento previo. Métodos: Dos modelos de Markov, utilizando los resultados publicados de superviviencia libre de progresión (SLP) de pacientes con LLC tratados con R-FC o FC en primera o segunda línea, las tasas...

  7. Manejo de schwannoma vestibular con radiaciones : experiencia del IVO

    OpenAIRE

    Arribas Alpuente, Leoncio Alfonso

    2013-01-01

    A partir de la década de los 70, nace la radiocirugía (RC) como tratamiento alternativo a la cirugía convencional en el tratamiento de los schwannomas vestibulares(SV). Poco a poco dicha técnica, ha ido desbancando a la microcirugía alcanzando cifras del 58 % de tratamientos de RC frente a la cirugía convencional. En el presente estudio analizamos el resultado de 167 tumores tratados con radiaciones (bien con dosis única (RC) o con dosis fraccionada, RT Estereotáctica Fraccionada (RTEF)...

  8. El Tratado Antártico, vehículo de paz en un campo minado

    Directory of Open Access Journals (Sweden)

    M. Cristina Prieto Larrain

    2004-01-01

    Full Text Available El 99% de la superficie de la Antártica, esto es 14 millones de Km², está cubierta por hielos de unos 2 Km de profundidad. Además de ser el continente más frío, la Antártica es también el más seco, ventoso y alto del mundo, con una elevación media de 2.500 Mt. Tales características físicas explican la ausencia de población humana indígena en el área, así como lo tardío de su exploración y explotación por parte de estados europeos y americanos entre otros. Sólo a partir del siglo XVIII comienzan las expediciones al territorio antártico, con finalidades que van desde la investigación científica, pasando por la pesca de ballenas, hasta intentos de anexión territorial por parte de alguna nación. Conforme avanza el siglo XX, continúa la penetración del continente y los reclamos de soberanía sobre distintas áreas de la zona. Esto dio pie a disputas y choques entre estados. Durante la II Guerra Mundial amenazaba con transformarse en un nuevo escenario de enfrentamiento bélico entre las fuerzas enemigas. A lo largo de la Guerra Fría, se ve con temor que la Antártica podría ser tomada como centro de pruebas de armamento convencional y nuclear. A fin de evitar estos males y regularizar la explotación y exploración del continente, nació el Sistema del Tratado Antártico o STA. El régimen fue creado en 1958-1959 y pretendió detener las demandas de soberanía territorial además de salvaguardar el área de cualquier amenaza nuclear y militar. Aunque las partes signatarias tienen un evidente interés de futura anexión territorial, y el STA no ha logrado dar solución al problema de la soberanía sobre el continente, al menos ha congelado una peligrosa fuente de discordia e inestabilidad regional y mundial. Especialmente interesantes son los casos de Chile, Argentina y el Reino Unido, cuyas demandas territoriales sobrepuestas constituyen un buen ejemplo del choque de los títulos de soberanía esgrimidos por diversas

  9. Therapeutic Efficacy of Ginger, Cisplatin and Radiation on Chemically-Induced Cancer in Male Albino Rats

    International Nuclear Information System (INIS)

    This study aimed to investigate the in vivo effect of dietary supplementation with ginger to evaluate its therapeutic effect against lung and kidney cancer and in combination with cisplatin as chemotherapy and radiotherapy in male albino rats. 54 male albino rats were divided into nine groups of 6 animals each, all animals were allowed to food and water ad libitum . Group I was treated with 0.5 ml saline, orlly for 12 consecutive weeks serve as con - trol group Group II injected with N-nitrosodimethylamine (NDMA) and carbon tetrachloride (CCl4 ); all groups were injected with NDMA + CCl4 for 6 weeks. Group III were given ginger for 6 consecutive weeks (200 mg/kg, b.wt./day). Group IV animals received cisplatin, group V irradiated with 2 Gy, group VI treated with ginger then irradiated, group VII treated with ginger then injected with cisplatin, group VIII injected with cisplatin then irradiated and group IX treated with ginger and cisplatin then irradiated. Antioxidant status in both kidney and lung tissues were estimated by determining the activity of antioxidant enzyme superoxide dismutase (SOD); as well as the level of reduced glutathione (GSH), Malondialdehyde (MDA) and Nitric oxide (NO). In parallel to histopathological investigations of lung and kidney tissues. In addition, Tumor Necrosis Factor Alpha (TNF-α) level, advanced oxidative protein product (AOPP), urea, creatinine and uric acid. Remarkable disturbances were observed in the levels of all tested parameters in NDMA + CCl4 group. On the other hand, rats injected with the cancer agents then treated with cisplatin+radiation showed moderate improvements in the studied parameters while, treatment with ginger + cisplatin + radiation ameliorated the levels of the disturbed bio

  10. Chelala, Ninou. – L’albinos en Afrique

    OpenAIRE

    Missié, Jean-Pierre

    2011-01-01

    Au moment où les médias internationaux se délectent de faits divers relatant les actes de violence faite aux albinos en Afrique de l’Est notamment (crimes en vue de prélever des parties du corps pour des besoins de fétiches, viol, stigmatisations), ce livre vient fort à propos bien qu’il semble n’avoir pas été suffisamment relu. Il pose malgré tout des questions pertinentes. Articulé sur trois chapitres (« Inventions historico-sociales de l’albinos » ;« La construction de l’identité de l’alb...

  11. ACUTE ORAL TOXICITY OF MUCUNA PRURIENS IN SWISS ALBINO MICE

    Directory of Open Access Journals (Sweden)

    Parekar Sushant Shahaji

    2011-05-01

    Full Text Available Mucuna pruriens, belonging to the botanical family Fabaceae, has been used in traditional Ayurvedic Indian medicine for various ailments including Parkinson’s disease. The current study reports the outcome of acute oral toxicity investigation of ethanolic extract of M. pruriens (whole plant on Swiss albino mice. No mortalities or evidence of adverse effects have been observed in Swiss albino mice following acute oral administration of ethanolic extract of M. pruriens at the dose of 2000 mg/ kg. This is the first report on the acute oral toxicity of M. pruriens and thus the findings of this study provide scientific validation on the use of the M. pruriens as a medicine for treating various ailments.

  12. Evaluación de la fusión segmentaria con técnica TLIF con cajas de PEEK en patología degenerativa lumbar: ¿ es la radiografía dinámica útil para el diagnóstico de fusión segmentaria en pacientes tratados? Avaliação de fusão intersomática com técnica TLIF e dispositivo em PEEK em degeneração lombar: a radiografia dinâmica é útil para o diagnóstico da fusão intersomática em pacientes tratados? Evaluation of the intersomatic fusion with TLIF technique and PEEK cages: is the dynamic X Ray useful for the diagnosis for intersomatic fusion in instrumented patients?

    Directory of Open Access Journals (Sweden)

    Alejandro Ferrer

    2012-06-01

    Full Text Available OBJETIVO: Evaluar la eficiencia de las radiografías dinámicas en el diagnóstico de fusión intersomática mediante la comparación interobservador con TAC haciéndose cortes finos y reconstrucción en 3D. MÉTODO: Fueron evaluados 25 pacientes, entre diciembre de 2004 y marzo de 2010, operados por medio de técnica TLIF con caja de PEEK, chips óseos autólogos de cresta ilíaca (precaja e intracaja e instrumentación pedicular de titanio en 1 solo segmento lumbar. Estos 25 casos fueron evaluados en forma aleatoria por los 3 autores del trabajo; las radiografías dinámicas consignaron en cada una si el segmento presentaba fusión (A o no (B según el hallazgo de movilidad segmentaria. De la misma manera, se evaluaron los cortes de TAC, buscando el signo centinela y el signo centinela posterior (A presente y (B ausente. RESULTADOS: Según la apreciación de los autores y de acuerdo con la lectura de las Rx dinámicas, 24 de los 25 pacientes (96% no presentaban movilidad segmentaria alguna, considerándos elos, por ende, fusionados. Por el contrario, la observación de las TAC con cortes de 1mm y reconstrucción en 3D mostró signos compatibles con fusión en 17 pacientes (68%. CONCLUSIÓN: El método de selección para el diagnóstico de fusión intersomática es la TAC con cortes de 1mm y reconstrucción en 3D.OBJETIVO: Avaliar a eficiência de radiografias dinâmicas no diagnóstico de artrodese por meio da comparação interobservadores com TC de corte fino e reconstrução 3D. MÉTODOS: Foram avaliados 25 pacientes operados entre dezembro de 2004 e março de 2010 pela técnica TLIF e uso do dispositivo em PEEK, utilizando-se lascas ósseas de osso autólogo da crista ilíaca (pré-dispositivo e intradispositivo e instrumentação com parafusos pediculares de titânio em um único nível lombar. Esses 25 casos foram randomicamente avaliados pelos três autores; os casos foram classificados por presença ou ausência de mobilidade segmentar

  13. Immunomodulatory Activity of Abutilon Indicum linn on Albino Mice

    OpenAIRE

    N. L. Dashputre; , N. S. Naikwade

    2010-01-01

    Purpose: To study the immunomodulatory activity of aqueous and ethanol extracts of leaves of Abutilon indicum Linn. (Family: Malvaceae) on albino mice. Methods: The ethanolic and aqueous extract of leaves of Abutilon indicum was administered orally at the dosage levels of 200 mg/kg/day and 400 mg/kg/day body weight in mice. The assessment of immunomodulatory activity on specific and non-specific immunity were studied by heamagglutination antibody (HA) titer, delayed type hypersensitivity (DTH...

  14. Preliminary acute toxicity study on imidacloprid in Swiss albino mice

    OpenAIRE

    Preeti Bagri; Vinod Kumar; Anil Kumar Sikka; Joginder Singh Punia

    2013-01-01

    Aim: To ascertain the maximum tolerated dose (MTD) and to investigate the acute oral toxic effects of imidacloprid towards Swiss albino male mice.Materials and Methods: The MTD of imidacloprid was determined in pilot dose range finding study following the standard method. Animals were observed for toxic signs and symptoms after oral administration of MTD of imidacloprid in single dose. The body weights of animals were recorded on alternate day. Animals were sacrificed on 14th day and changes ...

  15. ANTICONVULSANT ACTIVITY OF MORINGA OLEIFERA IN SWISS ALBINO MICE

    OpenAIRE

    Anu Elizabeth Joy; Padmini Thalanjeri; Shyamjith Manikkoth

    2015-01-01

    Objectives : The aim of the study was to investigate anticonvulsant effect of Moringa oleifera on maximal electroshock (MES), pentylenetetrazole (PTZ) and pilocarpine induced seizures. Methods : The ethanolic extract of Moringa oleifera leaves (200mg/ Kg) was used to study its anticonvulsant effect on MES, PTZ and pilocarpine induced seizures in Swiss albino mice. Suppression of the tonic hind limb extension, duration of convulsion, abolition of convulsions was noted respectively for the abov...

  16. PRIMARY CNS MELANOMA IN AN ALBINO: A RARE CASE REPORT

    OpenAIRE

    Kishore; Bhardwaj; Gupta; Seema; Kudesia

    2014-01-01

    Primary intracranial melanoma is a rare and uncommon lesion. Association of primary CNS melanoma in an albino has not been reported in literature searched till now. We are presenting a rare case of primary CNS melanoma in a 52years old male with occulocutaneous albinism. The patient presented with repeated episodes of generalized headache, vomiting and ataxia for duration of 5months. MRI examination showed a tumor in the posterior fossa that was diagnosed as Ependymoma radiologically. Surgica...

  17. CONTENIDO DE FENOLES TOTALES EN FRUTOS DE MANGO ′SUPER HADEN′ DAÑADOS POR ANTRACNOSIS Y TRATADOS EN POSCOSECHA

    Directory of Open Access Journals (Sweden)

    Akira Pérez Márquez

    2016-01-01

    Full Text Available El contenido de fenoles totales en el exocarpio de los frutos tiene relación con los mecanismos de defensa propios del fruto frente al ataque por patógenos fúngicos. Colletotrichum gloeosporioides (Penz. Penz. & Sacc. es causante de la antracnosis en el mango (Mangifera indica L. y ocasiona elevadas pérdidas en poscosecha. El objetivo de este trabajo fue evaluar el contenido de fenoles totales en frutos de mango ‘Super Haden’ dañados y tratados en poscosecha y evidenciar su relación con los mecanismos de defensa frente a la infección por patógenos. Se tomaron muestras de exocarpios de frutos sanos y con niveles de daños ligeros, moderados y severos por la antracnosis, así como en frutos tratados en poscosecha con agua caliente (53 ºC por 5 min, cera polietilénica (10 % ST más imazalil (800 mg L-1, cera polietilénica (10 % ST más imazalil (800 mg L-1 más dos bolsas de Conserver 21 y un testigo sin aplicación. Las muestras se liofilizaron y se determinó el contenido de fenoles totales por el método sugerido por Slinkard y Singleton (1977 con modificaciones. Los frutos afectados por la antracnosis presentaron menores contenidos de fenoles totales en el grado ligero fue de 59,25, en el moderado de 58,63 y en el severo 56,52 mg de ácido gálico g-1de masa fresca, mostrándose diferencias significativas entre los grados y frutos sanos. Los tratamientos poscosecha incrementaron el contenido de fenoles totales. El agua caliente y la combinación de cera polietilénica con imazalil mostró valores de 37,58 y 37,11 mg de ácido gálico g-1respectivamente, en comparación con el testigo que fue 33,94 mg de ácido gálico g-1, existiendo una correspondencia con la disminución de la incidencia de la enfermedad.

  18. Evaluation of analgesic activity of perindopril in albino mice

    Directory of Open Access Journals (Sweden)

    R N Suresha

    2014-01-01

    Full Text Available The aim was to evaluate the analgesic activity of perindopril in chemical, thermal and mechanical pain on Swiss albino mice. A total of 54 albino mice (Swiss strain weighing 25-30 g were allocated to each experimental model and in each model there were three groups. The control group received normal saline (25 ml/kg per orally, standard group received pentazocine (10 mg/kg intra-peritoneal and test groups received perindopril (1 mg/kg per orally. Perindopril and normal saline was administered 2 h before, whereas the pentazocine was administered 15 min prior to Eddy′s hot plate, writhing and tail clip methods. The decrease in number of writhes, the delay in reaction time in tail clip and Eddy′s hot plate method denoted the analgesic activity. Perindopril decreased the number of writhes, delayed the reaction time in tail clip and Eddy′s hot plate method considerably when compared with control (normal saline, but less when compared with standard (pentazocine. Perindopril exhibits analgesic activity in thermal, chemical, and mechanical pain models in albino mice.

  19. Linfoma hepático primario: Evolución favorable con quimioterapia combinada con rituximab Primary hepatic lymphoma: favorable outcome with chemotherapy plus rituximab

    Directory of Open Access Journals (Sweden)

    I. Serrano-Navarro

    2008-11-01

    Full Text Available Comunicamos el caso de una paciente con un linfoma hepático primario tratado con éxito con quimioterapia combinada con rituximab. Utilizando los "encabezamientos estándar para búsquedas bibliográficas informatizadas" (Medical Subject Heading revisamos los casos publicados hasta la fecha de esta infrecuente entidad.This article describes the case of a patient with a non-Hodgkin primary hepatic lymphoma who was successfully treated with chemotherapy combined with rituximab. Using the Medical Subject Headings the published reports of this rare entity were reviewed.

  20. Los tratados de arquitectura en los fondos de la Biblioteca Histórica de la Universidad Complutense: una aproximación al estudio de sus procedencias y antiguos poseedores.

    Directory of Open Access Journals (Sweden)

    Lizarraga Echaide, Juan Manuel

    2009-07-01

    Full Text Available La Biblioteca Histórica de la Universidad Complutense de Madrid atesora una importantísima colección de tratados de arquitectura El objeto de este artículo es reconstruir la historia de esta singular colección de libros antiguos de gran riqueza y valor y recuperar la procedencia estos tratados tanto con respecto a las bibliotecas de las instituciones docentes que forman parte de la historia de la Universidad como a las importantes bibliotecas personales que se han ido incorporando a su patrimonio bibliográfico. El conocimiento de las antiguas procedencias constituye una información valiosa que permite nuevas oportunidades de investigación histórica y bibliográfica

  1. NUEVO CRITERIO INTERPRETATIVO DE LOS DERECHOS FUNDAMENTALES CONFORME A LOS TRATADOS INTERNACIONALES DE DERECHOS HUMANOS EN LA CONSTITUCIÓN ESPAÑOLA

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    Alejandra Flores Martínez

    2011-12-01

    Full Text Available RESUMEN. En las siguientes líneas se pretende argumentar a la luz del ordenamiento jurídico español la existencia de razones jurídicas (válidas y suficientes para catalogar como “criterio interpretativo de los Derechos Fundamentales” a los Tratados Internacionales de Derechos Humanos, aportando cuatro tipos de argumentos: El primero, se deduce de la naturaleza jurídica de los tratados como fuentes del Derecho Internacional y como obligaciones internacionales para el Estado. El segundo, deriva de la incorporación automática de los Tratados al Derecho interno consolidándose como parte del ordenamiento jurídico. El tercero, es la pauta interpretativa que cuenta con respaldo constitucional en el artículo 10.2 de la Constitución Española. El cuarto, deriva de la insuficiencia de los criterios tradicionales al momento de interpretar las normas de los Derechos FundamentalesABSTRACT. The following lines pretend to argue in light of the Spanish law the existence of legal reasons (valid and sufficient to classify the international human rights treaties as "interpretive criteria for Fundamental Rights", providing four types of arguments: The first is inferred from the legal nature of treaties as sources of international law and international obligations for the State. The second derives from the automatic incorporation of treaties into national law establishing itself as part of the law. The third is the interpretative guidance that counts with constitutional support in Article 10.2 of the Spanish Constitution. The fourth derives from the failure of the traditional criteria when interpreting the rules of Fundamental Rights.

  2. Las indicaciones geográficas en el TLC firmado por Colombia y Perú con EUA frente al TLC con Chile.

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    Juan Andrés Zarama Medina

    2007-06-01

    Full Text Available El propósito de este trabajo es hacer un análisis crítico del tratamiento que se ha dado a las Indicaciones Geográficas y mas específicamente a las Denominaciones de Origen en el Tratado de Libre Comercio que firmaron recientemente por Colombia y Perú, con los Estados Unidos (TLC, al que en adelante denominaremos TLC CAN, y compararlo con el TLC firmado con Chile (En adelante TLC CHILE. Para efectos de este trabajo, centraremos nuestra atención de manera específica en la tendencia de estos tratados a tratar las indicaciones geográficas y en especial las denominaciones de origen, como marcas colectivas y de certificación o garantía.

  3. El lugar de la sátira en la poética: los tratados españoles del siglo XIX

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    González Alcázar, Felipe

    2008-12-01

    Full Text Available This article aims to analyse the satirical genre and its connections with Poetics in the Spanish Poetry and Rhetoric precept treatises of the nineteenth century. Throughout that century, literary theory was subject to major changes, such as the success of Hegel’s postulates on literary genres. Satire faces these changes and its own evolution: it was first identified with the Roman satura and afterwards through its various forms, it became a mixed or transitional genre. Its fragile nature seems to confront directly the normative perpetuity of treatises that, in spite of their rupture with romanticism, may be considered inheritors of the classicist principles.Se propone en este artículo investigar el género satírico y sus relaciones con la Poética a través de los tratados poético-retóricos de preceptiva españoles del siglo XIX. A lo largo de toda esa centuria la teoría literaria estuvo sujeta a grandes transformaciones, entre ellas, el triunfo de los principios hegelianos acerca de los géneros literarios. La sátira se enfrenta a esas mismas transformaciones y a su propia evolución: primero, identificada con la satura romana, y luego, a través de sus numerosas formas, convertida en un género mixto o de transición. Su lábil naturaleza parece enfrentarse directamente con la perennidad normativa de los tratados que, a pesar de la ruptura romántica, pueden considerarse herederos de los principios clasicistas.

  4. TRATADOS INTERNACIONALES DE DERECHOS HUMANOS BAJO EL ORDENAMIENTO JURÍDICO ALEMÁN

    Directory of Open Access Journals (Sweden)

    Roland Bank

    2003-01-01

    Full Text Available En el presente artículo el autor analiza la posición de los tratados internacionales en general, como asimismo, los tratados de derechos humanos y de integración en el sistema jurídico alemán, considerando la posición de la doctrina y la jurisprudencia emanada de la Corte Constitucional Alemana.The article analyzes the status in the German legal system of international treaties in general, and treaties on human rights and integration in particular, from the point of view of legal scholarship and the decisions of the German Constitutional Court.

  5. Logros en educacion secundaria y su relacion con inteligencia y con resolucion de problemas nuevos

    OpenAIRE

    Nuria Cortada de Kohan

    1998-01-01

    En esta investigación, que es una segunda parte de la ya presentada en esta Revista Latinoamericana de Psicología. Vol. 29, N° 1, 1997, hemos tratado de profundizar en la relación entre procesos de pensamiento, inteligencia general y logros en educación. Hemos utilizado un proyecto metodológicamente similar al usado con los alumnos primarios elaborando tests de conocimientoadhoc para alumnos del último año de la Escuela Secundaria. Asimismo hemos aplicado a la misma muestra ...

  6. Spatiotemporal features of early neuronogenesis differ in wild-type and albino mouse retina

    Science.gov (United States)

    Rachel, Rivka A.; Dolen, Gul; Hayes, Nancy L.; Lu, Alice; Erskine, Lynda; Nowakowski, Richard S.; Mason, Carol A.

    2002-01-01

    In albino mammals, lack of pigment in the retinal pigment epithelium is associated with retinal defects, including poor visual acuity from a photoreceptor deficit in the central retina and poor depth perception from a decrease in ipsilaterally projecting retinal fibers. Possible contributors to these abnormalities are reported delays in neuronogenesis (Ilia and Jeffery, 1996) and retinal maturation (Webster and Rowe, 1991). To further determine possible perturbations in neuronogenesis and/or differentiation, we used cell-specific markers and refined birth dating methods to examine these events during retinal ganglion cell (RGC) genesis in albino and pigmented mice from embryonic day 11 (E11) to E18. Our data indicate that relative to pigmented mice, more ganglion cells are born in the early stages of neuronogenesis in the albino retina, although the initiation of RGC genesis in the albino is unchanged. The cellular organization of the albino retina is perturbed as early as E12. In addition, cell cycle kinetics and output along the nasotemporal axis differ in retinas of albino and pigmented mice, both absolutely, with the temporal aspect of the retina expanded in albino, and relative to the position of the optic nerve head. Finally, blocking melanin synthesis in pigmented eyecups in culture leads to an increase in RGC differentiation, consistent with a role for melanin formation in regulating RGC neuronogenesis. These results point to spatiotemporal defects in neuronal production in the albino retina, which could perturb expression of genes that specify cell fate, number, and/or projection phenotype.

  7. Calidad de vida de pacientes con cáncer de próstata en tratamiento con bloqueo androgénico continuo vs intermitente: estudio prospectivo mediante la aplicación del cuestionario CAVIPRES

    OpenAIRE

    C.R. Sierra Labarta; D. Sánchez Zalabardo; Á. de Pablo Cárdenas

    2015-01-01

    Fundamento: El tratamiento con bloqueo androgénico intermitente (BAI) pretende mejorar la calidad de vida de los pacientes con cáncer de próstata con los mismos resultados oncológicos que el bloqueo androgénico continuo (BAC). El presente trabajo compara la calidad de vida mediante la aplicación del cuestionario CAVIPRES entre dos grupos de pacientes, uno tratado con BAC y otro con BAI. Material y métodos: Se realizó un estudio longitudinal de 24 meses de duración que incluyó 114 pacientes. T...

  8. Oral toxicity of Madhuca butyracea Macb. saponins to albino rats.

    Science.gov (United States)

    Lalitha, T; Vishwanatha, S; Venkataraman, L V

    1990-07-01

    Saponins, isolated from M. butyracea, were assessed for their acute and subacute oral toxicity in albino rats. Acute doses of saponins caused mortalities and LD50 and LD90 values were 330 and 430 mg/kg body wt respectively. Severe diarrhoea, restlessness and histopathological changes were observed in liver and kidney. Diets containing saponins at 0,250,500 and 1000 ppm for 14 weeks did not affect food intake, growth or organ weights, but induced mild histological changes in liver and kidney and altered the serum levels of alkaline phosphatase, blood urea nitrogen, cholesterol and proteins, particularly in female rats. PMID:2272650

  9. Hepatopancreatic intoxication of lambda cyhalothrin insecticide on albino rats

    OpenAIRE

    Elhalwagy, Manal EA; Abd-Alrahman, Sherif H; Nahas, AA; Ziada, Reem M; Mohamady, Aziza H

    2015-01-01

    Background: Despite the known adverse effects of lambda cyhalothrin insecticide, little is known about its hepatopancreatic intoxication effects. The present study was carried out to elucidate sub-chronic effect of Karat 2.5% EC formulation of lambda cyhalothrin on male albino rats. Methods: To explore the effects of exposure to lambda cyhalothrin on rats and its mechanism, low (1/40 of LD50, 5 mg/kg/day) and high dose (1/4 of LD50, 50 mg/kg/day) lambda cyhalothrin were applied to rats via dr...

  10. Una nota sobre los tratados de libre comercio y la productividad en el Perú

    OpenAIRE

    Aquije, María; Céspedes, Nikita; Sánchez, Alan

    2014-01-01

    Presenta una breve reseña de los resultados de Céspedes y otros (2014), en donde se estudia la relación entre la productividad de las empresas y los Tratados de Libre Comercio para el caso de la economía peruana.

  11. Determination of quality constituents in the young leaves of albino tea cultivars.

    Science.gov (United States)

    Feng, Lin; Gao, Ming-Jun; Hou, Ru-Yan; Hu, Xiao-Yi; Zhang, Liang; Wan, Xiao-Chun; Wei, Shu

    2014-07-15

    Albino tea has received increased attention due to its brisk flavour. To identify changes in the key chemical constituents conveying important qualities to albino tea, the metabolite profiles of four albino cultivars and one green tea cultivar were analysed. Compared to the green tea control, significantly decreased contents of chlorophyll (Chl) (ptea leaves with a few exceptions, whereas increases were noted in the Chl a/b ratio and the contents of both zeaxanthin and free amino acids, including theanine. Multivariate analysis identified catechins and carotenoids as the most important contributors to the metabolic profile variance between the albino and green tea cultivars. High levels of amino acids, along with low levels of chlorophylls, catechins and caffeine, contribute to the qualities of albino tea, which include reduced astringency and bitterness, along with a strong umami taste. PMID:24594160

  12. Técnica dramática y retórica de las pasiones en el Tratado completo del arte del canto de Manuel García

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    Díaz Marroquín, Lucía

    2007-12-01

    Full Text Available The history of European singing technique, from the Italian origins of the stile rappresentativo and the early Seicento musical drama to the heights of bel canto, seems inextricably related to the classical rhetorical and philosophical theories, later re-interpreted by the humanist and rationalist authors. Manuel García’s Tratado completo del arte del canto inherits this tradition and contributes to it with every single observation or musical example included in this eminently practical work.

    Desde los orígenes italianos del stile rappresentativo y del drama musical, en los últimos años del siglo XVI y primeros del XVII, hasta el esplendor del bel canto, la historia de los tratados de canto europeos se encuentra inseparablemente asociada a las teorías retóricas y filosóficas clásicas, más tarde reinterpretadas por los autores humanistas y preenciclopedistas. Al escribir su Tratado completo del arte del canto, una obra eminentemente práctica, Manuel García hereda esta tradición y contribuye a ella con cada una de las observaciones y ejemplos musicales que propone.

  13. [Thoracic duct valves in man and albino rat].

    Science.gov (United States)

    Petrenko, V M; Kruglov, S V

    2004-01-01

    The aim of this research was to determine the number, structure and position of valves along the whole length of thoracic duct in man and albino rat. The study was performed using the material obtained from 30 human corpses of men and women aged 17 to 60 years with no history of cardiovascular pathology and from 60 outbred albino rats of both sexes aged 5 to 12 months. Material was fixed in 10% neutral formalin. Anterior wall of thoracic duct was longitudinally dissected. Thoracic duct of 30 rats was stained with gallocyanin-chrome alum, in the remaining animals it was studied after its injection with blue Gerota's mass. In most cases, the valves consisted of two semilunar cusps. Thoracic duct was found to contain on the average 14.7+/-0.2 valves in man and 11.9+/-0.2 valves in rat. Most of all valves were found in the upper (anterior) 1/3 of the thoracic duct, least--in its middle part. This seems to be determined by anatomo-topographic features of the different parts of thoracic duct. PMID:15839250

  14. Melanoma maligno em búfalos (Bubalus bubalis albinos

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    Maria Cecília Florisbal Damé

    2015-10-01

    Full Text Available Descrevem-se melanomas múltiplos em dois búfalos albinos da raça Murrah no Sul do Brasil. Macroscopicamente havia múltiplos tumores enegrecidos no músculo esquelético, pulmões, linfonodos, saco pericárdio, cápsula renal, mediastino e pleura. Microscopicamente foram observadas células epitelióides poliédricas dispostas em ninhos sólidos ou fascículos entrelaçados sustentadas por um estroma colagenoso fino e esparso. O citoplasma era eosinofílico e por vezes continham quantidades variáveis de pigmento de melanina. A taxa de mitose foi baixa. Na imuno-histoquímica houve imunomarcação positiva utilizando anticorpo anti-tirosinase, anti-Melan-A, anti-vimentina, anti-proteína S-100 e antineurofilamento. É possível que o polimorfismo relacionado com o gene da pigmentação em búfalos albinos tenha contribuído para o maior risco de desenvolvimento de melanomas, como foi sugerido em humanos.

  15. Effect of acetylsalicylic acid on spermatogenesis in adult albino mice

    International Nuclear Information System (INIS)

    Spermatogenesis in male albino mice. Study Design: Laboratory based randomized controlled trial. Place and Duration of Study: Department of Anatomy University of Health Sciences, Lahore from Apr, 2012 to Dec, 2012. Material and Methods: Thirty nine male albino mice, 6-8 weeks old weighing 30 - 5 gm, were used; these were randomly divided into three groups having thirteen mice in each using random numbers table. Group A served as a control and was given distilled water orally via oral gavage 10 ml per kg for 30 days. Group B was given acetylsalicylic acid 100 mg/kg dissolved in 10 ml distilled orally for a period of 30 days. Group C was given acetylsalicylic acid 25 mg/kg dissolved in 2.5 ml distilled orally for a period of 30 days. Animals were sacrificed 24 hours after the last dose and the testes were removed, fixed in Bouin's fixative for 48 hours. Five microns thick sections of processed tissue were stained with H and E and PAS for calculation of Johnsen score and diameter of seminiferous tubules. Serum testosterone level was measured by testosterone enzyme immunoassay test kits. Results: Microscopic examination demonstrated that ASA treatment lead to statistically significant increase in the mean Johnsen score and mean diameter of seminiferous tubules. Conclusion: It was concluded from the current study that ASA treatment enhances spermatogenesis. (author)

  16. ANÁLISIS DEL PERFIL DE COMPUESTOS VOLÁTILES DEL MANGO (Mangifera indica L. Var. Tommy Atkins TRATADO POR MÉTODOS COMBINADOS

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    Angélica Moreno

    2010-09-01

    Full Text Available Se evaluó el perfil de compuestos volátiles del mango (Mangifera indica L. Var. Tommy Atkins al ser tratado con la combinación de los métodos de deshidratación osmótica con o sin pulso de vacío (DOPV y DO y con secado por aire caliente o con vacío (SAC y VAC. El tiempo utilizado en la cinética del proceso de DO fue de 42 horas y la DOPV de 30 horas; en los procesos de secado, el SAC se realizó durante 24 horas y el VAC requirió 40 horas. En el perfil de compuestos volátiles del mango fresco analizado por cromatografía de gases acoplada a detector de espectrometría de masas (GC-MS se encontraron compuestos tipo mono y sesquiterpénico, además de ácidos y ésteres grasos. El germacreno D (20,49% fue el compuesto terpénico de mayor abundancia encontrado en el análisis realizado. La cantidad de compuestos volátiles en la fruta procesada fue afectada por la aplicación de DOPV y VAC; sin embargo estas pérdidas fueron menores que en las muestras secadas sin pretratamiento osmótico. En el análisis sensorial realizado, las frutas tratadas con DOPV y DO presentaron una menor intensidad calificada en el olor en comparación con la muestra no pretratada.

  17. La transmisión del saber médico: la vida infantil en la Edad Media a través de los tratados pediátricos y de otras fuentes de la época

    OpenAIRE

    Cabrera Sánchez, Margarita

    2006-01-01

    En este trabajo se analizan diversos temas relacionados con la vida de los niños en la Edad Media, contemplados a través de la información contenida en los tratados médicos y también en los testimonios gráfi cos conservados. La investigación se ha estructurado en diversos capítulos que versan sobre los cuidados que se prodigan a los niños (higiene, vestido, alimentación) y sobre las dolencias más comunes que afectaban a la infancia. In this paper we analyze several topics co...

  18. Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka)

    Institute of Scientific and Technical Information of China (English)

    ZHAO Heling; YANG Hongsheng; ZHAO Huan; LIU Shilin; WANG Tianming

    2012-01-01

    Albino Apostichopus japonicus occur both in the wild and in captivity.The offspring of albino A.japonicus also suffer from albinism.The formation of melanin in the melanocytes is dependant on microphthalmia-associated transcription factor (MITF).To investigate the role of MITF in controlling albinism,we cloned the full-length MITF cDNA from A.japonicus and compared MITF mRNA expression in albino and normal A.japonicus.In addition,we used light and electron microscopy to compare histological samples of normal and albino A.japonicus.The body wall of albino adults was characterized by significantly lower levels of MITF expression and lower numbers of epidermal melanocytes,which also contained less melanin.In albino juvenile offspring,MITF expression levels were significantly lower 32 d after fertilization and there were fewer,and less developed,epidermal melanocytes.Thus,we conclude that albino A.japonicus have fewer melanocytes and a reduced ability to synthesize melanin,likely because of lower expression of MITF.

  19. Estudio de Calidad de Vida de los pacientes infectados por el virus de la inmunodeficiencia humana con lipodistrofia facial tratada

    OpenAIRE

    Jorge Sánchez, Ramón José

    2015-01-01

    [ES] Objetivo: Identificar las características de la calidad de vida de los pacientes infectados por el VIH diagnosticados y tratados de lipoatrofia facial en comparación con el resto de pacientes seropositivos. Metodología: Diseño: Estudio descriptivo observacional transversal de casos y controles. Sujetos: Casos: Pacientes con lipodistrofia facial tratada (n = 61); Controles: pacientes infectados por el VIH sin lipodistrofia facial (n = 61), reclutados en Salamanca y Ferrol y en s...

  20. Estudio de calidad de vida de los pacientes infectados por el virus de la inmunodeficiencia humana con lipodistrofia facial tratada

    OpenAIRE

    Jorge Sánchez, Ramón José

    2015-01-01

    [ES]Objetivo: Identificar las características de la calidad de vida de los pacientes infectados por el VIH diagnosticados y tratados de lipoatrofia facial en comparación con el resto de pacientes seropositivos. Metodología: Diseño: Estudio descriptivo observacional transversal de casos y controles. Sujetos: Casos: Pacientes con lipodistrofia facial tratada (n = 61); Controles: pacientes infectados por el VIH sin lipodistrofia facial (n = 61), reclutados en Salamanca y Ferrol y en seg...

  1. The 'evil albino' stereotype: an impediment to the right to equality.

    Science.gov (United States)

    Mswela, Maureen

    2013-03-01

    This article address the 'evil albino' plot device or albino bias as portrayed in films and explores how such labelling stimulates societal intolerance and discrimination against People Living With Albinism. The article reveals how media perpetuates stereotypes of albinism through their portrayal of role players and argues that the continued existence of such stereotypes is a failure to see albinism for what it is: a medical condition. The article further discusses Albinism related stigma and discrimination against the backdrop of the 'evil albino' plot device. PMID:23781766

  2. The Albino Rat Following Oral Administration Of A-Chlorohydrin

    Directory of Open Access Journals (Sweden)

    Fouad A.F.Ali*, Ali A.Abdel Rahman* and Ashraf M.Moustafa

    2001-09-01

    Full Text Available The antifertility effects of a- chlorohydrin were re-investigated in female albino rats. a.i/Kg. bw of and six females were ! " #$ The uterine changes were in the form of an increase lumenal folding with areas of metaplasia, some cellular vaculization and increased the collogen deposition in the % $ &!rd "th day of the drug intake. The ovarian changes were in the form of decreased number of growing follicles and absence of both Graafian follicles and corpora lutea. It is clear that, treatment of female rats with a chlorohydrin caused reversible uterine and ovarian changes. Uterine changes took longer time to recover compared with that of ovarian changes. These results support the possibility that this drug could be a functional female sterilant as it was known as a male sterilant.

  3. Histopathological effects of doxorubicin on pancreas in male albino rats

    Directory of Open Access Journals (Sweden)

    I.A. Ali

    2015-06-01

    Full Text Available The aim of this study was to investigate the histopathological side effects of doxorubicin on pancreas tissue in male albino rats Rattus norvegicus. This study were used 55 adult rats (2.5-3.5 month of age. The rats divided into two groups, the first group include (35 rats. The second group were (20 rats. Microscopial examination of pancreas lesion demonstrated oedema around the acini, swelling of the epithelial cells of acini, occurance of cystic fibrosis (mucoviscidosis at the concentration of (4,5 mg/kg of body weight ,occurrence of small islets that form of few cells and exocrine-endocrine transformation. There were thickness in the walls of blood vessels, thrombus, congestion of blood vessels, we conclude, that doxorubicin had histopathological effect on pancreas in sub-acute doses more than chronic doses.

  4. PRIMARY CNS MELANOMA IN AN ALBINO: A RARE CASE REPORT

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    Kishore

    2014-07-01

    Full Text Available Primary intracranial melanoma is a rare and uncommon lesion. Association of primary CNS melanoma in an albino has not been reported in literature searched till now. We are presenting a rare case of primary CNS melanoma in a 52years old male with occulocutaneous albinism. The patient presented with repeated episodes of generalized headache, vomiting and ataxia for duration of 5months. MRI examination showed a tumor in the posterior fossa that was diagnosed as Ependymoma radiologically. Surgical treatment with total removal of tumor was done. Intra-operative squash cytology and frozen section followed by histopathology confirmed the diagnosis of Melanoma. A thorough investigation of the patient was performed including chest radiography, ocular examination, ultrasonography of abdomen and barium enema to rule out any other site of primary melanoma in the body. Thus a final diagnosis of primary CNS melanoma was given.

  5. Water Hyacinth (Eichhornia Crassipes) Induced Hepatotoxicity in Albino Rats

    International Nuclear Information System (INIS)

    Total of 24 adult male albino rats were randomly assigned as treated and untreated control groups. Treated group supplemented with water hyacinth (Eichhornia crassipes) for 5 and 9 weeks. The results revealed that rats supplemented with water hyacinth (as a source of heavy metals) for 5 weeks induced significantly increase in RBCs, WBCs counts, hemoglobin content, Heinz bodies percentage and cell number/size ratio. At the same time liver cell size had a significant decrease under the same treatment. The ninth weeks of the experimental period showed a significant rise of Heinz bodies, globulin level, ALT level, liver cellular aspects (DNA, cell number and cell number/size ratio). A significant decrease of WBCs counts, A/G ratio and cell size were illustrated.The histological examination of treated rats liver showed chronic venous congestion with infiltration of the portal tract by chronic inflammatory cells and necrosis of hepatocyte cells consequently after 5 and 9 weeks of treatment

  6. Tratamiento quirúrgico de la espondilolistesis lumbosacra con las técnicas de Candebat

    OpenAIRE

    Echevarría Requeijo, Héctor de la Caridad

    2008-01-01

    Presentamos un estudio descriptivo y longitudinal de tipo prospectivo, en 47 pacientes con espondilolistesis lumbosacra, tratados con las técnicas de Candebat de instrumentación espinal en el Hospital Clínico Quirúrgico “Hermanos Ameijeiras”, desde enero 1999 a septiembre 2006, con el propósito de evaluar los resultados de estas técnicas quirúrgicas. Se seleccionaron los pacientes que no respondieron al tratamiento conservador durante seis meses o más. Veintiún enfermos (44,7%) pertenecen al...

  7. Neuroprotección con ozono en la terapia: nuevos hallazgos en la isquemia cerebral experimental.

    OpenAIRE

    J.D. García Salman; Silvia Menéndez; Rosa María Coro Antich; M. García Cabrera; A. Cuba Peña; Pérez-Saad, H.

    2005-01-01

    El tratamiento con ozono ha mostrado efectos terapéuticos en algunos estados patológicos relacionados con el estrés oxidativo. Nuestro objetivo fue investigar el efecto del tratamiento con ozono en los modelos de isquemia unilateral permanente y de isquemia bilateral transitoria en el gerbo mongol. El ozono se administró por vía rectal (1 mg/Kg). En la isquemia unilateral permanente los animales fueron tratados 3 semanas antes de la ligadura de una carótida. En IBT el tratamiento comenzó ante...

  8. RECONSTRUCCIÓN DEL MAXILAR SUPERIOR POSTERIOR ATRÓFICO CON CÉLULAS MADRE MESENQUIMALES

    OpenAIRE

    Martí Pagès, Carles

    2009-01-01

    Se realiza un estudio clínico en el lnstituto de Cirugía Maxilofacial e Implantologia tras pasar el comité ético del Centro Medica Teknon. Es un estudio randomizado, controlado utilizando un diseño tipo "split mouth" en el cual cada paciente sirve de propio control. SE realiza a 5 pacientes, con atrofia posterior del maxilar superior sin posibilidad de instalar implantes fueron tratados con reconstrucción mediante la técnica de elevación sinusal bilateral, rellenando un sena con Bio-as...

  9. Preliminary acute toxicity study on imidacloprid in Swiss albino mice

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    Preeti Bagri

    2013-12-01

    Full Text Available Aim: To ascertain the maximum tolerated dose (MTD and to investigate the acute oral toxic effects of imidacloprid towards Swiss albino male mice.Materials and Methods: The MTD of imidacloprid was determined in pilot dose range finding study following the standard method. Animals were observed for toxic signs and symptoms after oral administration of MTD of imidacloprid in single dose. The body weights of animals were recorded on alternate day. Animals were sacrificed on 14th day and changes in hematological parameters (Hb, TEC, TLC and DLC and morphometric measurements (length, breadth, thickness and weight of various body organs (heart, liver, spleen, kidney, testis and epididymis were examined. The student's t-test was applied to statistically analyze the results.Results: The MTD of imidacloprid was determined to be 110 mg/kg body weight. The sign and symptoms of acute toxicity were ataxia, rigidity and fasciculation of muscles, protrusion of eye ball and tremors of head. Imidacloprid treatment resulted in decreased body weight gain as compared to the control group. The changes in hematological parameters were not significant between imidacloprid treated and control groups. Also the values of relative organ weights and morphometric measurements of various body organs did not differ significantly between the control and imidacloprid treated animals.Conclusions: MTD of imidacloprid in Swiss albino male mice through oral route was determined for the first time. Study revealed a non-toxic effect of imidacloprid on body weight, relative organs weight, hematological parameters and morphometric measurements of various body organs in mice.

  10. Effect of lead acetate toxicity on experimental male albino rat

    Institute of Scientific and Technical Information of China (English)

    Nabil M Ibrahim; Esam A Eweis; Hossam S El-Beltagi; Yasmin E Abdel-Mobdy

    2012-01-01

    Objective: To evaluate the effect of different doses of lead acetate (1/20, 1/40 and 1/60 of LD50) on body weight gain, blood picture, plasma protein profile and the function of liver, kidney and thyroid gland. Methods: Male albino rats were divided into four groups, the first group represented the health control animals, while the second, third and fourth groups were ingested orally with sub lethal doses of lead acetate (1/20, 1/40 and 1/60) of the oral LD50, respectively. One dose was ingested every two days during the experimental period (14 weeks) including the adaptation time. Blood was collected and used for all analysis. Results: The results showed that, the ingestion of Pb2+ induced significant stimulation in glutamic-pyruvic transaminase (ALT) and glutamic-oxalacetic transaminease (AST) activity. Also, total soluble protein and albumin contents of plasma were significantly decreased, while the content of globulin was changed by the Pb2+ treatments. The cholinesterase activity was inhibited, but the activities of alkaline and acid phosphates and lactate dehydrogenase were stimulated, while plasma glucose level was elevated as a result of lead acetate intoxication. In case of blood picture, Pb2+ ingestion reduced the contents of hemoglobin and RBCs count of intoxicated rat’s blood and the plasma levels of T3, T4 and blood WBCs count were decreased. Conclusions: It can be concluded that lead acetate has harmful effect on experimental male albino rats. Therefore, the present work advises people to prevent exposure to the lead compound to avoid injurious hazard risk.

  11. Estudio de las propiedades superficiales y del post-suavizado de tejidos de lana y poliamida 6 tratados con plasma

    OpenAIRE

    Canal, Cristina

    2007-01-01

    La lana es una fibra natural que aunque posee propiedades de confort apreciadas por el consumidor, presenta el inconveniente de encoger durante el lavado en medio acuoso. En una época en que la tendencia en el cuidado de las prendas es el "easy-care" (cuidado fácil), es imperativo que cualquier producto textil sea lavable a máquina. Por ello se han desarrollado numerosos tratamientos para prevenir el encogimiento de las prendas de lana. Sin embargo, la estricta legislación ambiental de los pa...

  12. Perfil y realidad social de los cuidadores principales de pacientes dependientes tratados con hemodiálisis

    OpenAIRE

    Andreu Periz, Lola; Moreno Arroyo, M. Carmen

    2009-01-01

    La sociedad actual presenta 2 características sociosanitarias impensables en otras épocas: el espectacular aumento de la esperanza de vida y la cronicidad de muchas enfermedades. La esperanza de vida en los países occidentales ha pasado en menos de 5 décadas de los 60 a los 85 años, produciéndose el fenómeno demográfico denominado el"envejecimiento del envejecimiento", por lo que se prevé que en el año 2016 los mayores de 80 años serán más del 6% de la población total. España es especialmente...

  13. Effect of co-administration of voglibose and vildagliptin on diabetic albino rats

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    Umashanker PD Keshri

    2016-08-01

    Conclusions: Vildagliptin and voglibose are effective in lowering blood glucose level in albino diabetic rats but their combination has potentiating effect. [Int J Basic Clin Pharmacol 2016; 5(4.000: 1533-1538

  14. Consequences of Mesobuthus tamulus gangeticus (Pocock, 1900 envenomation in albino mice

    Directory of Open Access Journals (Sweden)

    MK Chaubey

    2010-01-01

    Full Text Available The present study aimed to investigate the effects of Mesobuthus tamulus gangeticus Pocock (Buthidae venom on albino mice (NIH strain. Whole venom was obtained by electrical stimulation and its toxicity was determined in albino mice by subcutaneous envenomation. The venom LD50 was 2.5 mg kg-1 of mouse body weight. Toxic effects on different biochemical and enzymatic parameters in blood serum and other tissues of albino mice were determined after experimental envenomation with sublethal doses of M. tamulus gangeticus venom. Increased levels of glucose, uric acid and cholesterol, as well as decreased serum total proteins, were observed at 2 and 4 hours after the envenomation. In the liver and muscles, glycogen content dropped after venom injection. Moreover, M. tamulus gangeticus venom elevated the enzymatic activity of acid phosphatase (ACP, lactic dehydrogenase (LDH and alanine aminotransferase (ALT in the serum of albino mice. In conclusion, M. tamulus gangeticus can be considered a lethal scorpion species.

  15. Tratamiento conservador en pacientes con retinoblastoma bilateral

    Directory of Open Access Journals (Sweden)

    Juan C. Suárez

    2008-11-01

    Full Text Available OBJETIVO: comparar el tratamiento convencional del retinoblastoma bilateral, usado hasta hace algunos años, consistente en radioterapia o enucleación bilateral, con el tratamiento conservador actual que incluye termoterapia transpupilar (TTT o TTT/quimioterapia al menos en un ojo, en niños con diagnóstico de retinoblastoma bilateral. DISEÑO: estudio retrospectivo descriptivo. MUESTRA: 20 pacientes con diagnóstico de retinoblastoma bilateral que consultaron al Hospital Universitario San Vicente de Paúl, de Medellín, Colombia, entre 1997 y 2007. MÉTODO: se hizo enucleación del ojo con el tumor de mayor tamaño. En el otro ojo se hizo tratamiento con TTT, con el láser diodo (810 nm, spot amplio, solo o combinado con otras terapias. RESULTADOS: se dividió a los pacientes en dos grupos: 16 pacientes (32 ojos en el grupo 1 tratados conservadoramente y 4 pacientes (8 ojos en el grupo 2 con tratamiento convencional. El rango de edad fue de 1-72 meses en el grupo 1 y de 1-12 meses en el grupo 2. El tiempo de seguimiento fue de 7-67 meses para el grupo 1 y de 13-73 meses para el grupo 2. En el grupo 1 se hizo enucleación de 16 ojos (50%, radioterapia externa de uno (3,1%, quimioterapia más termoterapia de 5 (15,6% y quimioterapia más termoterapia más crioterapia de 10 (31,3%. En todos los pacientes se logró preservar al menos un ojo. En el grupo 2, se enuclearon 7 ojos (87,5% y se hizo radioterapia externa más enucleación en un paciente (12.5%. Además, todos los pacientes recibieron quimioterapia. CONCLUSIÓN: la terapia conservadora actual consistente en tratamiento local (termoterapia, crioterapia o braquiterapia y quimiorreducción permite preservar al menos un ojo y en algunos casos de los dos, muchas veces con buena agudeza visual, en niños con retinoblastoma bilateral; se evitan así la enucleación bilateral y la radioterapia externa usada en el tratamiento convencional con todos sus efectos secundarios. La enucleación contin

  16. Therapeutic effects of Cassia angustifolia in a cadmium induced hepatotoxicity assay conducted in male albino rats

    OpenAIRE

    Haidry, Muhammad Tahir; Malik, Arif

    2016-01-01

    The present study aims to investigate the therapeutic effects of Senna plant (Cassia angustifolia L.) in a cadmium induced hepatotoxicity assay by evaluating the activity of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and total protein (TP) in the albino rats’ serum. A total of 30 white albino rats were taken and divided into three groups; each group comprising ten rats. The group A was taken as a control group; group B was given cadmium chloride conce...

  17. Behavior of an albino vampire bat, Desmodus rotundus (E. Geoffroy) (Chiroptera, Phyllostomidae), in captivity

    OpenAIRE

    Wilson Uieda

    2001-01-01

    Albinism in the common vampire bat Desmodus rotundus (E. Geoffrey, 1810) was already reported for seven individuals, six of them did in Brazil. Although this species is relatively easy to keep in captivity and many studies with normally pigmented bats were did under laboratory conditions, no reports on detailed observations of captive albino vampire bats were found in literature. This paper reports some behavioral observation of a single albino female D. rotundus kept in captivity in Brazil b...

  18. Effect of Tectona grandis Linn. seeds on hair growth activity of albino mice

    OpenAIRE

    Jaybhaye, Deepali; Varma, Sushikumar; Gagne, Nitin; bonde, Vijay; Gite, Amol; Bhosle, Deepak

    2010-01-01

    The seeds of Tectona grandis Linn. are traditionally acclaimed as hair tonic in the Indian system of medicine. Studies were therefore undertaken in order to evaluate petroleum ether extract of T. grandis seeds for its effect on hair growth in albino mice. The 5% and 10% extracts incorporated into simple ointment base were applied topically on shaved denuded skin of albino mice. The time required for initiation of hair growth as well as completion of hair growth cycle was recorded. Minoxidil 2...

  19. HAIR GROWTH POTENTIAL OF EVOLVULUS ALSINOIDES LINN. PLANT EXTRACT IN ALBINO RATS

    OpenAIRE

    Bhaiji Amrita; Patil Umesh Kumar; Dave Suchi; Jain Arvind; Sahoo Himanshu Bhusan

    2012-01-01

    Evolvulus alsinoides Linn. (Convolvulaceae) is traditionally used for its hair growth promoting activity in rural community of Indian sub-continent. Studies were therefore carried out to evaluate petroleum ether and methanolic extracts of Evolvulus alsinoides for their effect on hair growth in albino rats. The extracts were incorporated into oleaginous base and applied topically on shaved denuded skin of albino rats for thirty days. The time required for hair growth initiation and completion ...

  20. ANTIDIABETIC AND HYPOLIPIDEMIC ACTIVITY OF GYMNEMA SYLVESTRE IN DEXAMETHASONE INDUCED INSULIN RESISTANCE IN ALBINO RATS

    OpenAIRE

    Hemanth Kumar V, Nagendra Nayak IM , Shobha V Huilgol, Saeed M Yendigeri , Narendar K

    2015-01-01

    Background: Gymnema sylvestre plant was widely used for medicinal purpose. The plant leaves were traditionally used to treat diabetes. Aim: To determine the antidiabetic and hypolipidemic activity of Gymnema sylvestre in dexamethasone induced insulin resistance in Albino rats. Objectives: The present study was undertaken to evaluate antidiabetic and hypolipidemic activity of Gymnema sylvestre leaf aqueous extract against dexamethasone induced insulin resistance in Albino rats. Materials and M...

  1. Ostracism of an Albino Individual by a Group of Pigmented Catfish

    OpenAIRE

    Ondřej Slavík; Pavel Horký; Matúš Maciak

    2015-01-01

    Physiological and behavioural constraints hinder albino individuals. Albino animals are rare in the wild; this trait is associated with easy detection by predators, non-native or damaged environments, and exclusively aphotic environments in total darkness. The social aspect of albinism is reported only for human beings, and the effect is distinguishable in time and space when social benefits, are used to a limited the extent. Thus far, the social consequences of albinism for animals remain un...

  2. Effect of vitamin D on atorvastatin induced blood sugar changes in Wistar albino rats

    OpenAIRE

    Arunkumar, R; Vinayak Meti; A. Ruckmani; Shobita Devi

    2014-01-01

    Background: Statins are hypocholestrolemic agents used in atherosclerotic vascular disorders. They act by inhibiting hepatic hypoxanthine methyl glutaryl CoA reductase enzyme. They are reported to cause hyperglycemia as an important adverse event. This study was conducted to investigate atorvastatin induced blood sugar changes in Wistar, albino, male rats and the influence of vitamin D on the blood sugar changes. Methods: Forty, 12 weeks old male, Wistar albino rats, were selected and rand...

  3. Impact on behavioral changes due to chronic use of sertraline in Wistar albino rats

    OpenAIRE

    Shatavisa Mukherjee; Sukanta Sen; Arunava Biswas; Tapan Kumar Barman; Santanu Kumar Tripathi

    2015-01-01

    Aim: Despite having better tolerability and a wide range of clinical applications over other antidepressants, selective serotonin reuptake inhibitors (SSRIs) are also known to be associated with serious adverse effects like suicidal ideation on chronic use. The present study had explored the impact of the chronic use of sertraline, an SSRI, on the behavioral changes in Wistar albino rats. Materials and Methods: The study was conducted on 30 Wistar albino rats of either sex; divided into f...

  4. Acute effect of aspartame-induced oxidative stress in Wistar albino rat brain

    OpenAIRE

    Ashok, Iyaswamy; Sheeladevi, Rathinasamy; Wankhar, Dapkupar

    2014-01-01

    Abstract The present study was carried out to investigate the acute effect of aspartame on oxidative stress in the Wistar albino rat brain. We sought to investigate whether acute administration of aspartame (75 mg/kg) could release methanol and induce oxidative stress in the rat brain 24 hours after administration. To mimic human methanol metabolism, methotrexate treated rats were used to study aspartame effects. Wistar strain male albino rats were administered with aspartame orally as a sing...

  5. El Camino de Paikín: un acercamiento a los grupos mocoví del Chaco a través del tratado de 1774

    Directory of Open Access Journals (Sweden)

    Florencia Nesis

    2008-07-01

    Full Text Available En 1774 y dentro de un programa que intentaba establecer paces con los grupos indígenas del Chaco se produjo el encuentro entre Jerónimo Matorras, gobernador del Tucumán y Paikín, líder Mocoví. Este encuentro, que tuvo lugar dentro del territorio chaqueño, dio lugar a la firma de un tratado que buscaba regular las relaciones entre ciertos grupos indígenas y el sector colonial La publicación de este tratado en varias obras de recopilación desde principios del siglo XX ayudó a crear una imagen acerca del comienzo del dominio político y territorial de los indígenas por parte de la sociedad hispanocriolla. En el presente trabajo proponemos releer el tratado de 1774 dentro del conjunto mayor de fuentes que se produjeron en torno a estas negociaciones para adentrarnos en las estrategias y prácticas políticas desplegadas, la modificación de las relaciones de alianza y enemistad y las condiciones de posibilidad de acción de cada uno de los sectores implicados.In 1774, in a program that tended to make peace with the Chaco aboriginal groups, a meeting was held between Jerónimo Matorras, governor of Tucumán, and Paikín, mocoví leader. This meeting, that took place inside the indigenous territory, gave rise to a treaty that looked to regulate different aspects of the interethnic relationships. The diffusion of this treaty in several compilation publications since the beginning of the XX century helped to create a concept of the colonial political and territorial domain over the indigenous groups. In this paper we propose to rethink the 1774 treaty putting it in relation with other documents that were also made on the basis of these negotiations. Through this analysis, we expect to delve into the political strategy, the change in the relationships of friendship and enmity between the indigenous groups and different colonial agents, and the action possibilities of each one.

  6. Shewanella algae en un paciente con diarrea crónica. Primer caso en Costa Rica

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    Erick Molina- Guevara

    2009-09-01

    Full Text Available Se presenta el caso de un paciente masculino, vecino de Pavas-San José, con historia de diarrea crónica. En el coprocultivo se identificó Shewanella algae. Casos de infección en humanos por esta bacteria son raros y se han encontrado, predominantemente localizadas, en piel, oídos y tejidos blandos con o sin bacteremia, en la mayoría de los cuales existe el antecedente de contacto con ambientes marinos. Shewanella algae es sensible a aminoglicósidos, carbapenemes, eritromicina y quinolonas, pero resistente a penicilinas. La sensibilidad a ampicilina y cefalosporinas es variable. Nuestro paciente fue tratado con cefalexina y tuvo una respuesta satisfactoria al mismo, con cese de los síntomas. De acuerdo con nuestro conocimiento este el primer caso documentado, en Costa Rica, de infección gastrointestinal por esta bacteria.

  7. Analgesia profunda con acupuntura / Deep analgesic with acupuncture

    OpenAIRE

    Villate Numa, María Fernanda

    2010-01-01

    El alivio del dolor por medio de la acupuntura se desarrollo en la China moderna después de 1945 con la influencia inicial de la medicina occidental. Según la teoría tradicional, la acupuntura es eficaz sólo cuando las agujas producen el fenómeno “De Qi”, descrito como una sensación ligeramente dolorosa, relajante y si los dedos del acupuntor notan que las agujas son aspiradas por el punto tratado. En el Occidente diferentes estudios han demostrado que la acupuntura estimula fibras aferentes ...

  8. Protocolo quirúrgico en la reconstrucción de la parálisis facial: nuestra experiencia tras 140 casos tratados Protocol in surgical treatment of facial paralysis after 140 treated cases

    OpenAIRE

    B. Hontanilla Calatayud; C. Aubá Guedea; A. Vila Sobral; J. Castro García; A. San Martín Maya; J. Botellé del Hierro; G. Rodríguez Losada; R. Gómez Ruiz; A. Bazán Álvarez

    2008-01-01

    El objetivo de este trabajo es presentar nuestro protocolo de actuación en el tratamiento quirúrgico de la parálisis facial tras 140 casos tratados entre los años 2000 y 2007. Este protocolo está basado en los resultados obtenidos con un nuevo sistema de captura del movimiento facial en 3D denominado "Facial Clima", que puede ser considerado como un método objetivo de medición de los resultados en la cirugía de reanimación facial. Así podría compararse en pacientes con parálisis facial, la ef...

  9. El tratado de Domingo de Andrade Excelencias, antigüedad y nobleza de la arquitectura (1695 y la tratadística de su tiempo

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    Fernández Gasalla, Leopoldo

    2008-12-01

    Full Text Available Domingo de Andrade, chief architect of Santiago de Compostela’s Cathedral between 1677 and 1710, was de foremost artistical personality of his generation in Galicia. He also became a new kind of artist, capable of combining the practise of his art in the most brilliant way with the elaboration of theoretical approaches to it. This paper analyzes the origin of his treatise “Excelencias, Antigüedad y Nobleza de la Arquitectura” conceptual structure, as well as its relations with the previous and contemporary apologetical literature.El arquitecto Domingo de Andrade, maestro de obras de la catedral de Santiago, además de actuar como principal figura de su generación en Galicia, encarnó un nuevo tipo de artista capaz conjugar la práctica más brillante de su disciplina con la elaboración de planteamientos teóricos. Esa nueva dimensión abría las puertas del mundo de las Artes Liberales, para él y sus colegas más distinguidos. El presente artículo analiza el origen de la estructura conceptual del tratado Excelencias, Antigüedad y Nobleza de la Arquitectura, así como sus vínculos con la literatura apologética precedente y contemporánea.

  10. Erythropoietin-Like Effects of Dihydroartemisinin in Wistar Albino Rats

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    Utoh-Nedosa U. Anastasia

    2011-01-01

    Full Text Available Artemisinin drugs were active during the intra-erythrocytic stage of malaria parasite infection. The activity of artemisinin and synthetic endoperoxides was related to their interaction with heme. The electrophillic intermediate formed from artemisinin in the presence of heme alkylates the protein portion of hemoglobin preferentially to the heme portion. Problem statement: Since there might be an interaction between artemisinin and the heme of the blood, we studied the effects of 5-day and 7-day oral Dihydroartemisinin (DHA treatments with 5 dosage regimens of dihydroartemisinin on the blood and six vital organs of Wistar albino rats. Approach: The dosages of DHA tested on 5 test adult Wistar albino rats (weight = 106-140 grams were 1, 2, 60 or 80 mg Kg-1 rat weight of DHA by oral intubation for 5 or 7 days. Four rats of similar weight which served as controls in each experiment were given distilled water equivalents of the administered doses of DHA. Another group of 5 test rats and four control rats (weight 75-90 gms were given 1 mg kg-1 rat weight of DHA or distilled water for 5 or 7 days and were allowed to rest for one week after which the treatment was repeated. Results: The findings of the study showed that Dihydroartemisinin (DHA had erythropoietin-like properties. In the study DHA produced dose, repetition and time dependent statistically significant increases in the Packed Cell Volume (PCV (PConclusion: This result suggested that the administered DHA inhibited its own stimulated statistically significant increases in the PCV and the WBC of the treated rats through an inhibitory (negative feed-back effect. The structure and composition of the blood cell types like the presence of large numbers of reticlocytes and left-shifted neutrophils in the blood samples of 5-day DHA -treated rats but not in those of 7-day DHA treated rats indicated that new haemopoiesis was actively going on in the first 5 days of DHA treatment but had slowed down

  11. Hepatotoxicity of ingested uranium in albino wistar rats

    International Nuclear Information System (INIS)

    Uranium exhibits both radiotoxic and chemotoxic properties. Common route of contamination is ingestion through drinking water. Uranium is mainly nephrotoxic and is also hepatotoxic to mammals including humans. The dose range at which it affects organs still remains in predicament. To study the effect of ingested uranium on enzymatic and histopathological changes of liver in albino wistar rats. Uranyl nitrate hexahydrate (UN) solutions were prepared at different concentrations in distilled water for administration. Healthy male and female albino wistar rats weighing 120±20 g were randomly divided into six groups, each group with five animals. Group 1 was the control. All the five treatment groups (group 2, group 3, group 4, group 5 and group 6) were orally administered with 0.156, 0.625, 2.5, 10 and 40 mg/kg/day of UN for 28 days duration. Blood samples collected on 29th day were analyzed for γ-glutamyltransferase (GGT), alkaline phosphatase (ALP), serum glutamic pyruvic transaminase (SGPT) and serum glutamic oxaloacetic transaminase (SGOT). In addition, histopathological examination of liver tissue was performed. Significant reduction by 61 and 46 % in GGT levels in female rats of groups 4 and 5 respectively while in male rats, increase of 55, 52 and 40 % in groups 3, 4 and 5 respectively were observed compared to control. In females, ALP levels were decreased by 38 % in group 2 and 29 % in group 4 while no changes were observed in males of control and test groups. SGPT level was decreased by 22 % in group 6 in females but increased by 29 and 35 % in groups 2 and 6 respectively in males, compared to control. In females, 25 % increase in SGOT levels in group 4 was observed, but decreased in group 5 and 6 by 26 and 22 % respectively. A 27 % increase in SGOT level in males was recorded in group 2 compared to control. No histopathological changes were observed in liver tissues of test groups or the control. Uranium causes dose-independent changes in key marker

  12. Hematological and Histological Response of Wister Albino Rat Rattus norvegicus a Dietary Supplement of Seaweed Diet Gracilaria edulis

    OpenAIRE

    Anbalagan, T

    2009-01-01

    A dietary supplementation of seaweed Gracilaria edulis haematological and histological responseof albino rat Rattus norvegicus .The blood protein, cholesterol, albumin, calcium, phosphorus and urea of theseaweed feed albino rats having an increased tendency during the experimentation when compared with controlrats. Its note mostly that the experimental rat showing a decreasing level of glucose when compared withcontrol rats. The oral picture of the haematological change of albino rat fed with...

  13. La carga funcional inmediata con implantes en pacientes edéntulos mandibulares: Técnica de Maló Immediate implant loading in mandible edentulous patients: Technique of Maló

    OpenAIRE

    E. Velasco Ortega; A. García Méndez; J.J. Segura Egea; R. Medel Soteras; López Frías, J.

    2006-01-01

    Introducción. El objetivo del presente estudio era valorar los resultados clínicos de la carga inmediata en el tratamiento con implantes oseointegrados de la mandíbula edéntula. Pacientes y métodos. Los pacientes edéntulos completos fueron tratados con implantes Microdent® con superficie con chorreado de arena y grabada con ácidos para la rehabilitación de la mandíbula edéntula mediante la colocación de 4 implantes en el sector anterior con carga funcional inmediata. Los implantes fueron eval...

  14. Evolución clínica de pacientes chilenos con tirosinemia tipo I tratados con 2-(2-nitro-4-trifluorometilbenzoil-1,3-ciclohexanediona (NTBC

    Directory of Open Access Journals (Sweden)

    Erna Raimann

    2012-02-01

    Full Text Available Background: Tyrosinemia type I is an inborn error of metabolism due to deficiency of fumarilacetoacetase. Acute presentation is with liver failure, hypophosphatemic rickets and peripheral neuropathy. Chronic presentation is with visceromegaly and subclinical rickets. The most severe complications are hepatic cancer and acute neurological crises. Without treatment, tyrosinemia type 1 is fatal. In 1992 treatment for tyrosinemia type 1 with 2-(2-nitro-4-trifluoromethybenzoyl-1,3-ciclohexanedione (NTBC was proposed. A clinical response was reported in 90% of patients. In cases that did not respond, a successful liver transplantation was performed, reducing mortality to 5%. Aim: To report the follow up of 12 patients treated with NTBC. Patients and Methods: Review of clinical records of 12 Chilean cases treated with NTBC at the Instituto de Nutrición y Tecnología de los Alimentos (INTA from January 2004 until June 2010. Results: In all patients, a rapid metabolic control was achieved. Two patients developed hepatocarcinoma. One of these patients died and one was successfully treated with liver transplantation. One patient died after receiving a liver transplantation. Nine patients have at present good liver function, but 2 had peripheral neuropathy due to late diagnosis and discontinuing NTBC treatment. Conclusions: Treatment with NTBC allows metabolic normalization in tyrosinemia type 1, prevents liver cirrhosis and hepatic cancer, improving survival rates and quality of life in the patients. Neonatal screening is essential for the early diagnosis of this treatable disease, that otherwise may be lethal.

  15. Biological dosimetry of patients with differenced carcinoma of thyroid treated with Iodine-131; Dosimetria biologica de pacientes con carcinoma diferenciado de tiroides tratados con Iodo-131

    Energy Technology Data Exchange (ETDEWEB)

    Vallerga, M. B.; Rojo, A.M.; Taja, M.R.; Deluca, G.; Di Giorgio, M. [Autoridad Regulatoria Nuclear Av. Del Libertador 8250 (C1429BNP). Buenos Aires (Argentina); Fadel, A. [Hospital General de Agudos Dr. Carlos Durand Av. Diaz Velez 5044. Buenos Aires (Argentina); Cabrejas, M.; Valdivieso, C. [Hospital de Clfnicas Jose de San Martin Av. Cordoba 2351 (CP1120). Buenos Aires (Argentina)]. e-mail: mvallerg@cae.arn.gov.ar

    2006-07-01

    The administration of I-131 to patient with Differentiated Thyroid Carcinoma (CaDiT) it is used inside the therapeutic outline as later step to the thyroidectomy. However, the good activity to give is of difficult determination due to factors such as, the variability in the capacity of tumoral reception of the I-131, distribution of the pharmaceutical, physiologic status, other associate pathologies, grade of advance of the illness, and previous treatments. Additionally, the activity to administer is dependent of the dose of tolerance in the healthy tissues; superior dose to 2 Gy in bone marrow, its could drive to myelotoxicity. At the moment, the form more extended of administration it is the empiric prescription that considers clinical parameters and of laboratory for their determination. Presently work, the protocol of applied treatment incorporates the evaluation for internal dosimetry and biological dosimetry to estimate absorbed dose in bone marrow. The biological estimate of the dose of these patients is based on the quantification of chromosomal aberrations whose frequency is referred to a curve-dose response in which the lymphocytes is irradiated in vitro with I-131, allowing to determine the in vivo dose to the patient's circulating lymphocytes. The objective of the present work is to determine the applicability of different cytogenetic essays in the estimate of the absorbed dose to the whole body or specific organs. Three patients were evaluated with CaDiT. Their treatment protocol consisted on a tracer administration of radioactive iodine of 74 - 111 MBq (2 - 3 mCi) and a therapy 7,4 - 11,1 GBq (200 - 300 mCi). Previous to the tracer administration and 8 days post-therapeutic administration took samples of veined blood that were evaluated by biological dosimetry by means of the application of the techniques: conventional cytogenetic Micronucleus and FISH (Hybridization in situ by Fluorescence). Starting from the frequencies of observed chromosomal aberrations it was considered absorbed dose to whole body. The obtained doses were compared by the different biological methods used. The evaluation by internal dosimetry of the data obtained tracer post-activity allowed to personalize the activity of I-131 to administer, starting from physical-mathematical models that consider the particular biokinetics of each patient (MIRD methodology). The doses estimated by the used biological dosemeters were consistent among them. It was discussed its scopes and limitations to be applied in the validation of the dosimetric estimation based on models, in order to administer a therapeutic dose protecting the patient of the adverse effects of the internal radiotherapy in organs that are not target of the same one. The acquired experience is considered of utility to give answer in cases of radioiodine incorporation in occupationally exposed personnel. (Author)

  16. Evaluación del proceso de reparación en heridas de mucosa oral de conejos injertadas con tejido conjuntivo artificial autólogo elaborado con soportes de colágeno unidireccionales y multidireccionales

    OpenAIRE

    Escalante Herrera, Andrea del Pilar

    2013-01-01

    Los defectos de mucosa oral son tratados con autoinjertos que generan alta morbilidad en el sitio donante. Una alternativa de tratamiento es la elaboración de tejidos artificiales, que podría ayudar a superar algunas restricciones de los tratamientos convencionales. El objetivo de este trabajo fue evaluar clínica e histomorfométricamente el proceso de reparación en heridas de mucosa oral injertadas con tejido conjuntivo artificial autólogo (TCAA) elaborado con soportes de colágeno unidireccio...

  17. Un regimen sanitatis contra la peste: el tratado del licenciado Vázquez

    Directory of Open Access Journals (Sweden)

    de la Peña Barroso, Efrén

    2012-12-01

    Full Text Available The regimina pestis or plague treatises are the main literary genre where late medieval doctors reflected their medical concern about plague and pestilences. These medical texts, in which some practical recommendations were given to people to avoid and/or cure the effects of epidemic disease of high letality, were developed since the outbreak of the epidemic in 1348. The text now presented is a treatise on plague written by the «licenciado Vázquez», a converso from the archbishopric of Toledo who was tried by the Inquisition at the beginning of the 16th Century.Los regimientos o tratados contra la peste o pestilencia son expresión del modo en que los médicos universitarios bajomedievales hicieron frente a la enfermedad epidémica de alta letalidad. Estos textos médicos, que consistían en un repertorio más o menos amplio de recomendaciones prácticas para prevenir y/o tratar dicha enfermedad, experimentaron un notable desarrollo a partir de la peste negra de 1348. El texto que se ofrece a continuación es un tratado inédito contra la peste escrito por el licenciado Vázquez, un judeoconverso toledano que fue procesado por el Tribunal de la Inquisición a principios del siglo XVI.

  18. EL SISTEMA EUROPEO DE DERECHOS FUNDAMENTALES TRAS LA ENTRADA EN VIGOR DEL TRATADO DE LISBOA

    Directory of Open Access Journals (Sweden)

    Lorenzo Martín-Retortillo Baquer

    2011-07-01

    Full Text Available Resumen: En 1947 se pusieron las bases de lo que llegaría a ser la Unión Europea, a modo de organización comercial para sectores concretos, complejo que iría creciendo, ampliándose los fines y la organización, a la par que se fraguaba un complejo ordenamiento jurídico. Se hizo necesario alcanzar una declaración de derechos que incluyera los modernos derechos sociales. En el trabajo se estudia la compleja historia de la obtención de la declaración, la “Carta de Derechos Fundamentales de la Unión Europea”, que, al fin, entraría en vigor el 1.XII.2009, a la par que el último de los Tratados de la Unión, el Tratado de Lisboa.Abstract: The European Union was founded in 1947 as a concrete trade organization but it started to grown. The aims and the organization had increased and in the meantime a complex law system was set up. It was convenient to get a solid bill of rights including the modern social rights. The paper studies the complicate story of how to obtain the bill of rights –the “Carta of Fundamentals Rights of the European Union”- which formally came into effect the 1.XII.2099 at the same time that the last Treaty of the Union, the Treaty of Lison.

  19. El Tratado de no Proliferación Nuclear: la vigencia de la norma en América Latina

    OpenAIRE

    Adela Cubillos Meza

    2005-01-01

    RESUMEN En este artículo se analiza la posición de los países de América Latina frente al Tratado de No Proliferación Nuclear TNP. Este Tratado entró en vigencia el año 1968 al que se adhirió una gran cantidad de países. Los artífices del TNP fueron las potencias nucleares, Estados Unidos y la ex Unión Soviética, para controlar la proliferación nuclear. Este Tratado ha sido objeto de grandes críticas porque discrimina entre Estados Poseedores de Armas Nucleares y Estados No Poseedores de Arma...

  20. Estudio comparativo de las maloclusiones de clase III tratadas con y sin cirugía

    OpenAIRE

    Martínez Asúnsolo, Pascual

    2014-01-01

    El objetivo de la presente tesis fue determinar si existen diferencias en la inclinación de los incisivos superiores e inferiores en pacientes de clase III tratados con cirugía o únicamente con “camuflaje ortodóncico”, así como su repercusión en la relación esquelética final. Para ello se realizó un estudio clínico comparativo y retrospectivo en la unidad docente de Ortodoncia del departamento de Estomatología de la Universidad de Valencia. La muestra consistió en 56 pacientes que cump...

  1. Fracturas del húmero proximal: su tratamiento con clavos bloqueados proximales

    OpenAIRE

    Arenas Planelles, Antonio; D'Arrigo, A.; Arenas Miquélez, A.; Duart, J.

    2012-01-01

    Se presentan 27 casos de fractura de húmero proximal tratados mediante osteosíntesis con clavo proximal bloqueado. Los resultados fueron buenos en la mayor parte de los pacientes, con un dolor medio de 11,67/15 en la cotación cifrada de Constant, una fuerza de 14/25 puntos y una movilidad de 20,52/40 puntos. Las complicaciones más importantes fueron el conflicto subacromial (29,6%), la consolidación viciosa de la fractura en varo (29,6%) y la protrusión de los tornillos de bloqueo...

  2. Tratamiento de las fracturas diafisarias de húmero mediante osteosíntesis con placa

    OpenAIRE

    Zamora Rodríguez, J. M.; Modrego Aranda, Francisco Javier; Seral García, Belén; Seral Iñigo, Fernando

    2002-01-01

    Hemos tratado 22 facturas agudas diafisarias de húmero mediante reducción abierta y fijación con placa AO entre 1991 y 1999. Todas las fracturas excepto una consolidaron en un plazo medio de 94 días. De acuerdo con el criterio de Brumback los resultados fueron excelentes o buenos en el 90% de los casos. La complicación postoperativa más importante fue la parálisis del nervio radial en 3 casos; todos se recuperaron espontáneamente en un plazo medio de 108 días. La fijación interna mediante pla...

  3. Modelado farmacocinético de ciclofosfamida en pacientes con cáncer de mama.

    OpenAIRE

    Llopis García, Mª Carmen

    2009-01-01

    El objetivo principal es establecer un modelo estructural farmacocinético poblacional, en pacientes con cáncer de mama de alto riesgo tratados con ciclofosfamida a dosis altas, para predecir su respuesta individual.Los objetivos Secundarios son explorar mecanismos fisiológicos condicionantes de la autoinducción metabólica de ciclofosfamida. Detección de subpoblaciones de pacientes a través de parámetros de eliminación de ciclofosfamida. Plantear la influencia de covariables, a través del anál...

  4. Estructura textual y gestión informativa en hablantes con afasia

    OpenAIRE

    Gallardo-Paúls, Beatriz

    2013-01-01

    Uno de los temas más tratados por la bibliografía sobre cerebro y déficit lingüístico es el referido a cómo los hablantes que sufren de daño cerebral (tanto aquellos con afasia como los lesionados hemisferio derecho), desarrollan la elaboración de sus textos, prestando especial atención a la construcción de narraciones. En este trabajo analizamos un corpus de narraciones procedentes del Corpus PerLA, para describir cómo los hablantes con lesión de hemisferio izquierdo gestionan las categoría...

  5. Puente a trasplante cardiaco con oxigenación de membrana extracorpórea

    OpenAIRE

    Torregrosa Puerta, Salvador

    2012-01-01

    PUENTE A TRASPLANTE CARDIACO CON OXIGENACIÓN DE MEMBRANA EXTRACORPÓREA Objetivos: Los nuevos sistemas de Oxigenación de Membrana Extracorpórea (ECMO) han presentado un desarrollo tecnológico notable, fundamentalmente debido a la incorporación de oxigenadores y bombas centrífugas de larga duración, lo cual ha conducido a una importante mejoría en la supervivencia de los pacientes en shock cardiogénico refractario tratados con este tipo de asistencia mecánica circulatoria de corta duración. ...

  6. Chronic alcoholism-mediated metabolic disorders in albino rat testes

    Directory of Open Access Journals (Sweden)

    Shayakhmetova Ganna M.

    2014-09-01

    Full Text Available There is good evidence for impairment of spermatogenesis and reductions in sperm counts and testosterone levels in chronic alcoholics. The mechanisms for these effects have not yet been studied in detail. The consequences of chronic alcohol consumption on the structure and/or metabolism of testis cell macromolecules require to be intensively investigated. The present work reports the effects of chronic alcoholism on contents of free amino acids, levels of cytochrome P450 3A2 (CYP3A2 mRNA expression and DNA fragmentation, as well as on contents of different cholesterol fractions and protein thiol groups in rat testes. Wistar albino male rats were divided into two groups: I - control (intact animals, II - chronic alcoholism (15% ethanol self-administration during 150 days. Following 150 days of alcohol consumption, testicular free amino acid content was found to be significantly changed as compared with control. The most profound changes were registered for contents of lysine (-53% and methionine (+133%. The intensity of DNA fragmentation in alcohol-treated rat testes was considerably increased, on the contrary CYP3A2 mRNA expression in testis cells was inhibited, testicular contents of total and etherified cholesterol increased by 25% and 45% respectively, and protein SH-groups decreased by 13%. Multidirectional changes of the activities of testicular dehydrogenases were detected. We thus obtained complex assessment of chronic alcoholism effects in male gonads, affecting especially amino acid, protein, ATP and NADPH metabolism. Our results demonstrated profound changes in testes on the level of proteome and genome. We suggest that the revealed metabolic disorders can have negative implication on cellular regulation of spermatogenesis under long-term ethanol exposure.

  7. Immunomodulatory Activity of Abutilon Indicum linn on Albino Mice

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    N. L. Dashputre

    2010-04-01

    Full Text Available Purpose: To study the immunomodulatory activity of aqueous and ethanol extracts of leaves of Abutilon indicum Linn. (Family: Malvaceae on albino mice. Methods: The ethanolic and aqueous extract of leaves of Abutilon indicum was administered orally at the dosage levels of 200 mg/kg/day and 400 mg/kg/day body weight in mice. The assessment of immunomodulatory activity on specific and non-specific immunity were studied by heamagglutination antibody (HA titer, delayed type hypersensitivity (DTH, neutrophil adhesion test and carbon clearance test. In order to induced immunosuppresion in mice by using cyclophosphamide (100 mg/kg/day, p.o. and levamisole (50mg/kg/day, p.o. used as immunostimulating agents. Results: Oral administration of A. indicum showed a significant increase in the production of circulating antibody titre in response to sheep red blood cells (SRBCs. A significant (p<0.01 increase in both primary and secondary HA titre was observed when compared to control group, whereas in cyclophosphamide treated group A. indicum showed ignificant (p<0.01 increase in HA titre. A. indicum showed ignificantly (p<0.01 potentiated the DTH reaction by facilitating the footpad thickness response to SRBCs in sensitized mice. Also A. indicum evoked a significant (p<0.01 increase in percentage eutrophil adhesion to nylon fibers and phagocytic activity.Conclusion: The study demonstrates that A. indicum triggers both pecific and non-specific responses to a greater extent. The study comprised the acute toxicity and preliminary phytochemical screening of A. indicum. From the results obtained and phytochemical studies the immunostimulant effect of AI could be attributed to the flavonoid content.

  8. Micronuclei frequency in albino rats exposed to high natural radiation

    International Nuclear Information System (INIS)

    Genotoxicity and DNA damage endpoints are used to evaluate results in the context of cell survival. Genotoxicity in mammalian cells is monitored mostly by using cytokinesis-block micronucleus (CBMN) assay. The score of micronuclei (MN) in peripheral blood lymphocytes can be used as a biomarker and also as a bio-dosimeter of radiation exposure. In the present study the effect of natural radiation on albino rats has been investigated, to find out if there is any increase in MN frequency in peripheral blood lymphocytes. Animals at the age of 2-3 weeks were exposed to natural radiation, at the dose of 10.38 μGyh-1 for a period of 6 months. A parallel control set was also maintained (0.12 μGy h-1'). Blood samples were collected from both test (exposed to natural radiation) and control rats. Lymphocyte culture was done following 'microculture techniques' for 72 h. Cytochalasin B, at a concentration of 6.0 μg/ml, was added to the lymphocyte cultures at 44 h to block cytokinesis. The frequency of MN was evaluated by scoring a total of 1000 binucleated (BN) cells from one slide. The frequency of MN among the rats exposed to natural radiation was found to be 1.83±0.05 per 1000 BN cells and in the control it was 1.82±0.07 per 1000 BN cells. No statistically significant difference in the MN frequencies of exposed and control groups (p>0.05) was seen. The lower MN frequency in natural radiation exposed rats could be an indication of adaptive response. (author)

  9. PROTECTION ROLE OF CALCIUM THERAPY IN IRRADIATED MALE ALBINO RATS

    International Nuclear Information System (INIS)

    Free oxygen radicals and insufficiency of antioxidant enzymes have been implicated in the pathogenesis of radiation syndrome. The trace elements are functioning as co-factors in antioxidant enzymes. The antioxidant system and trace elements have been investigated in many different studies including tissue repair processes but this study deal with radiation injury in male albino rats.The study was carried out to investigate the beneficial role of the used metallo element as radio-protector due to its ability for chelating free radicals produced by ionizing radiation. The efficacy of daily oral treatment of rats with calcium glubionate (daily 6 mg/kg body wt) for 6 successive days to control many of the damaging effects of ionizing radiation when these rats subjected to 6 Gy whole body gamma ray were studied. The activity of catalase (CAT) and levels of total cholesterol (TC), triacylglycerols (TG) and malondialdehyde (MDA) in serum were determined. In addition, CAT activity and contents of reduced glutathione (GSH) and MDA in liver, kidney and spleen tissues of control, calcium treated, irradiated and protected rat groups were evaluated. Samples were collected from animals 24 hours after end of the Ca- glubionate treatment or exposure to gamma radiation. The data obtained revealed that, radiation exposure caused significant alterations in all tissues and serum biochemistry. On the contrary, neutralization was occurred in these biochemical aspects in protected animal groups due to Ca-glubionate treatment. In conclusion, Ca-glubionate could protect rats against biochemical alterations associated with gamma ray oxidative stress. These effects were explained in the light of the presumed different mechanisms of Ca-glubionate

  10. Radioprotection of Swiss albino mice by Adhatoda vesica leaf extract

    International Nuclear Information System (INIS)

    Full text: The radioprotective role of aqueous extract of Adhatoda vesica leaf extract against radiation induced hematological alterations in peripheral blood of Swiss albino mice was studied at various post-irradiation intervals between 6 hrs to 30 days. Oral administration of Adhatoda vesica leaf extract (800 mg / kg body weight) prior to whole-body irradiation showed a significant protection in terms of survival percentage and hematological parameters. Mice exposed to radiation (8 Gy) without Adhatoda vesica leaf extract pre-treatment exhibited signs of radiation sickness like anorexia, lethargicity, ruffled hairs and diarrhoea and such animals died within 26 days post-irradiation. The dose reduction factor (DRF=1.6) for Adhatoda vesica leaf extract was calculated from LD50/30 values. A significant decline in hematological constituents (RBCs, WBCs, Hb and Hct) was evident till day 15, at later period of observation (day 15 onwards), no animals could survive from control group whereas, in Adhatoda vesica leaf extract pre-treated irradiated group, a gradual recovery was noted in the hematological values. However, these hematological values remained significantly below the normal even till day 30. A significant decrease in GSH was recorded in control animals. Experimental animals showed a significant increase in GSH content (blood as well as liver) with respect to control, but such values remained below normal. A significant increase in TBARS level in liver and serum was evident in control animals. Although, no significant difference was noticed in such levels in normal and Adhatoda vesica leaf extract treated animals. But, a significant decrease was registered in Adhatoda vesica leaf extract pretreated irradiated animals. The results from the present study suggest that Adhatoda vesica leaf extract has radioprotective role in stimulating/protecting the hematopoietic system thereby enhancing the survival and increasing the hematological constituents in peripheral

  11. El tratamiento con implantes en pacientes edéntulos totales mandibulares mediante rehabilitación fija Etiologic role of virus in periodontal diseases

    OpenAIRE

    E. Velasco Ortega; J. Pato Mourelo; A. García Méndez; J.M. Lorrio Castro; J.M. Cruz Valiño

    2007-01-01

    Introducción. El objetivo del presente estudio era mostrar los resultados del tratamiento con rehabilitación fija mediante implantes dentales en pacientes edéntulos totales mandibulares. Métodos. 29 pacientes fueron tratados con 190 implantes Microdent ® con superficie con chorreado de arena para la rehabilitación fija mandibular. Los implantes fueron cargados después de un periodo de cicatrización de 3 meses. El seguimiento clínico fue al menos de 12 meses. Resultados. Los hallazgos clínicos...

  12. Ventilación mecánica no invasiva en el paciente con orden de no intubación

    OpenAIRE

    Soler Barnés, Juan Alfonso

    2009-01-01

    INTRODUCCIÓN: La Ventilación Mecánica No Invasiva (VMNI) se está convirtiendo en la medida inicial de soporte respiratorio en la mayoría de etiologías condicionantes de Insuficiencia Respiratoria Aguda (IRA). Sin embargo, su uso es controvertido en los pacientes con “orden de no intubación” (ONI). METODOLOGÍA: Estudio prospectivo y observacional realizado durante 10 años en una UCI sobre pacientes con IRA, con o sin ONI, tratados con VMNI. El seguimiento fue de 1 año. RESULTADOS: Se reclutaro...

  13. Legitimidad y finalidad de los capítulos de propiedad intelectual en los tratados de libre comercio (TLC)

    OpenAIRE

    Susy Frankel

    2011-01-01

    Una visión analítica de la realidad actual permite apreciar un auge de los Tratados de Libre Comercio, mientras se presenta un estancamiento en las negociaciones multilaterales de comercio. Si bien la negociación de los TLC no se limita a los países desarrollados, los negociados por los países en desarrollo no tienden a contemplar mejoras en los estándares de propiedad intelectual. Algunos de los capítulos relativos a la propiedad intelectual incluidos en los Tratados de Libre Comercio simple...

  14. Hypoglycemic effect of Brassica juncea (seeds) on streptozotocin induced diabetic male albino rat

    Institute of Scientific and Technical Information of China (English)

    T Thirumalai; S Viviyan Therasa; EK Elumalai; E David

    2011-01-01

    Objective: To evaluate the hypoglycemic effect of Brassica juncea (seeds) on streptozotocin induced diabetic male albino rats. Methods: Hypoglycemic activity of Brassica juncea (seeds) aqueous extract at a dose of 250, 350 and 450 mg/kg body weight was evaluated. Adult male Swiss albino rats of six numbers in each group was undertaken for study and evaluated. Results: The serum insulin levels were recorded a significant depletion in all groups, short term as well as long term diabetic animals, when compared to that of normal animals. A significant dosage dependent augmenting effect of the seed extract on the serum insulin was recorded in both short term as well as long term groups. Conclusions: The aqueous seed extract of Brassica juncea has potent hypoglycemic activity in male albino rat.

  15. Antidiarrhoeal efficacy ofMangifera indica seed kernel on Swiss albino mice

    Institute of Scientific and Technical Information of China (English)

    Rajan S; Suganya H; Thirunalasundari T; Jeeva S

    2012-01-01

    Objective:To examine the antidiarrhoeal activity of alcoholic and aqueous seed kernel extract of Mangifera indica (M. indica) on castor oil-induced diarrhoeal activity inSwiss albino mice.Methods:Mango seed kernels were processed and extracted using alcohol and water. Antidiarrhoeal activity of the extracts were assessed using intestinal motility and faecal score methods.Results:Aqueous and alcoholic extracts ofM. indica significantly reduced intestinal motility and faecal score inSwiss albino mice.Conclusions:The present study shows the traditional claim on the use of M. indica seed kernel for treating diarrhoea inSouthern parts of India.

  16. Histological Studies on Skeletal Muscles of Albino Rats under the Effect of Atorvastatin

    OpenAIRE

    Hassan S. A. El Dawi ,Gamal S. Elgharabawy ,Ezz El-Dein El Sharkawy,

    2013-01-01

    Introduction:The purpose of this study was to evaluate the effect of atorvastatin on the structure of skeletal muscles in male albino rats and the possibility of recovery of any changes in the muscles. Drug used: Atorvastatin (Lipitor 20mg) tablets.The daily single oral dose was 1.6 mg /kg body weight. Experimental animals: Twenty five adult local strain male albino rats with average weight of 160 gm were chosen, divided into five equal groups and fed on ordinary rat diet: Group I (co...

  17. Convulsive liability of bupropion hydrochloride metabolites in Swiss albino mice

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    McMahon Louis

    2008-10-01

    Full Text Available Abstract Background It is known that following chronic dosing with bupropion HCl active metabolites are present in plasma at levels that are several times higher than that of the parent drug, but the possible convulsive effects of the major metabolites are not known. Methods We investigated the convulsive liability and dose-response of the three major bupropion metabolites following intraperitoneal administration of single doses in female Swiss albino mice, namely erythrohydrobupropion HCl, threohydrobupropion HCl, and hydroxybupropion HCl. We compared these to bupropion HCl. The actual doses of the metabolites administered to mice (n = 120; 10 per dose group were equimolar equivalents of bupropion HCl 25, 50 and 75 mg/kg. Post treatment, all animals were observed continuously for 2 h during which the number, time of onset, duration and intensity of convulsions were recorded. The primary outcome variable was the percentage of mice in each group who had a convulsion at each dose. Other outcome measures were the time to onset of convulsions, mean convulsions per mouse, and the duration and intensity of convulsions. Results All metabolites were associated with a greater percentage of seizures compared to bupropion, but the percentage of convulsions differed between metabolites. Hydroxybupropion HCl treatment induced the largest percentage of convulsing mice (100% at both 50 and 75 mg/kg followed by threohydrobupropion HCl (50% and 100%, and then erythrohydrobupropion HCl (10% and 90%, compared to bupropion HCl (0% and 10%. Probit analysis also revealed the dose-response curves were significantly different (p 50 values of 35, 50, 61 and 82 mg/kg, respectively for the four different treatments. Cox proportional hazards model results showed that bupropion HCl, erythrohydrobupropion HCl, and threohydrobupropion HCl were significantly less likely to induce convulsions within the 2-h post treatment observation period compared to hydroxybupropion HCl. The

  18. Impact of oxidative stress on pregnancy outcome in albino rats

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    R.S. Al-Naemi

    2012-01-01

    Full Text Available Accumulative reports documented that oxidative stress is implicated in many human and animal diseases. However, the reports concerning the effect of oxidative stress on pregnancy outcome are limited and scarce. The objective of this study was to determine the impact of oxidative stress on pregnancy outcome and to assess the antioxidant effect of vitamin C and E on oxidative stress parameters in blood and placental tissue samples in experimental pregnant animals model exposed to oxidative stress. Wister Albino rats were used in this work to investigate the effects of oxidative stress exposure (addition of H2O2 to the drinking water on pregnancy outcome. Rats were divided into 5 groups, as follows: Group I (included 7 normal pregnant rats which served as control group. Group II (exposed to 1 % H2O2 included 7 pregnant rats, the rats were allowed to become pregnant and received (1% H2O2 in drinking water from day 7th till the day 19th of pregnancy. Group III (exposed to 3% H2O2 included 8 pregnant rats. Same as group 2, but the rats were exposed to a higher concentration of H2O2 (3% in drinking water. Group IV (included 8 pregnant rats. Pregnant rats received vitamins C and E without induction of oxidative stress. Group V (included 8 pregnant rats.induction of oxidative stress by 1% H2O2 with vitamins supplementation in the pregnant rats. Serum total antioxidants capacity (TAC, serum and placental tissue oxidative stress biomarker; 8-iso prostaglandin F2α (8-Isoprostane were measured using specific ELISA kits. Also placental tissues of pregnant rats were isolated and put directly in 10% formalin prepared for histopathological examination. Results revealed a significant decrease in the median values of the body weight and total serum antioxidants capacity (TAC in groups II and III of rats compared with the control group. A significant higher median value of TAC obtained in the groups IV and V when compared with the control group. Significant higher

  19. STUDIES ON INDUCED HEPATOTOXICITY IN MALE ALBINO RATS (RATTUS NORVEGICUS)

    International Nuclear Information System (INIS)

    Levanox, a hepato protective drug, and garlic powder have been considered as safe anti-oxidant agents. The present investigation refers to biochemical and molecular studies to evaluate the protective role of levanox and/or garlic powder toward CCl4-induced toxicity in adult male albino rats. CCl4 intoxication was attempted using a dose of 0.03 ml/kg of rat body weight.Pre-treatment with levanox (one capsule/ kg of rat body weight, each capsule contains 100 mg catechu, 7.5 mg dandelion, 75 mg termiric 2% curcumin, 17.5 mg silymarin, 100 mg lecithin) was more effective than garlic powder (100mg/kg of rat body weight) in reducing CCl4-induced hepatotoxicity as revealed by its higher potency in reducing elevation of aspartate (AST) and alanine (ALT) aminotransferases in serum. Serum of control rats and those treated with levanox or garlic or CCl4 produced 13 types of proteins, differing in the molecular weight (MW) and densities, while those of levanox + garlic or garlic +CCl4 produced 14 bands differing in the MW and densities. The similarity index at the epigenetic level was also studied using the primers under study. The control sample produced one amplified DNA fragment with Rf of 0.73 and a molecular size (MS) of 67 base pair (bp) . Using the same primers, no amplified DNA fragment with the same MS was produced in the sample taken from levanox + garlic treated group.OPA-2 primer of sequence 5?- AGA TGC AGC C-3? produced one amplified DNA band with MS of 292 bp and Rf of 0.46 . However, the same primer produced one amplified DNA characteristic band with a molecular size of 363 bp and Rf of 0.43 in the sample of levanox + garlic group.In the control sample, OPA-4 primer of sequence 5? - ACG CAC AAC C-3? produced one amplified DNA band of MS of 299 bp and Rf of 0.43. The same primer produced one amplified characteristic DNA band with MS of 363 bp and Rf of 0.43 in the sample of levanox + garlic group.Dual treatment with levanox and garlic powder resulted in a

  20. Sobre gnomos y gigantes: los tratados Grecorromanos y la igualdad soberana de los estados como ficción histórico-jurídica

    Directory of Open Access Journals (Sweden)

    Buis, Emiliano J.

    2011-12-01

    Full Text Available El presente trabajo inicialmente se aboca al estudio de los tratados que componen la Paz de Westfalia y su vínculo real con la construcción de la noción moderna de igualdad soberana de los Estados. A partir de este análisis crítico previo, la lección avanza sobre el estudio de las relaciones interestatales en el mundo griego y el romano, focalizándose principalmente en aquellos convenios celebrados antes de la era cristiana y en la necesidad de estos pueblos de recurrir a dichos instrumentos para fijar reglas de conducta previsibles. La hipótesis del trabajo, conforme a un vasto análisis de las situaciones propias del mundo antiguo, sugiere que aquellos Estados que se relacionaron en condiciones de desproporción de poder, siempre necesitaron acudir a un velo textual –convencional– de igualdad jurídica para disimular la real desigualdad de poder.

  1. Migración laboral México-Estados Unidos a veinte años del Tratado de Libre Comercio de América del Norte

    Directory of Open Access Journals (Sweden)

    Ana María Aragonés Castañer

    2015-01-01

    Full Text Available El fenómeno de la migración internacional de trabajadores está íntimamente relacionado con las desigualdades y las asimetrías del sistema capitalista y supone, además, la transferencia de plusvalía de los centros menos desarrollados hacia los polos industrializados o desarrollados. Si los países expulsores de migrantes se han ca-racterizado por aplicar políticas económicas que han ampliado los niveles de desempleo, la pau-perización de las condiciones laborales, la falta de apoyo al campo y el incremento del trabajo informal, en los países receptores los migrantes tienen una funcionalidad que se expresa en la diferencia existente entre el costo laboral unitario de los migrantes respecto de los trabajadores nativos. En este marco, el Tratado de Libre Co-mercio de América del Norte (1994 produjo una mayor subordinación económica de México hacia Estados Unidos y un crecimiento extraor-dinario de los flujos migratorios, en particular de la migración indocumentada, para los que no hubo ninguna protección ni cobertura legal.

  2. Solubilidade de metais pesados em solos tratados com lodo de esgoto enriquecido

    OpenAIRE

    Oliveira, C.; N. M. B. Amaral Sobrinho; Mazur, N.

    2003-01-01

    Os lodos de esgoto são materiais orgânicos ricos em nutrientes com potencial para o uso agrícola. A utilização desses materiais, no entanto, pode ser limitada pela presença de metais pesados na sua composição. Esta pesquisa teve por objetivos: (a) avaliar a solubilidade de Cd, Pb e Zn em dois tipos de solos tratados com lodo de esgoto enriquecido com esses metais; (b) verificar o efeito do tempo de contato nas mudanças da distribuição de Cd, Pb e Zn nas diferentes formas químicas de dois solo...

  3. DERECHOS HUMANOS Y TRATADOS QUE LOS CONTIENEN EN EL DERECHO CONSTITUCIONAL Y LA JURISPRUDENCIA DE ECUADOR

    Directory of Open Access Journals (Sweden)

    Marco A. Morales Tobar

    2003-01-01

    Full Text Available El artículo analiza los derechos humanos en la Carta Fundamental del Ecuador y sus garantías, considerando la situación de los tratados internacionales en general y los derechos humanos en particular, estableciendo su procedimiento de incorporación, ubicando su posición entre las fuentes del derecho y considerando su aplicación por la jurisdicción constitucional ecuatoriana.The present article analizes Human Rights and their guarantees in the Constitution of Ecuador, considering the situation of international treaties in general and human rights in particular. Attention turns then to procedures for their incorporation, placing international treaties within the system of law and considering their application by the Ecuadorian constitutional jurisdiction.

  4. Tratamiento del síndrome de apnea obstructiva del sueño (SAOS) asociado a síndrome de hipoventilación-obesidad (SHO): presión positiva continua (CPAP) versus ventilación con presión positiva BI-nivel (BIPAP)

    OpenAIRE

    Hernández Vázquez, Julio

    2012-01-01

    OBJETIVOS. El objetivo principal es valorar la eficacia del tratamiento con BiPAP en comparación con CPAP sobre la disminución de la pCO2 en pacientes con SAOS y SHO, a los 3 y 12 meses del inicio de su aplicación. Los objetivos secundarios son comparar la evolución de los pacientes tratados con BiPAP con la de los tratados con CPAP en términos de mejoría de la pO2 diurna, cambios en la pruebas de función respiratoria (FEV1 y FVC), control de la somnolencia que conlleva el SAOS medida mediant...

  5. La PAC tras el Tratado de Lisboa : procesos legislativos ordinarios y actos de ejecución

    OpenAIRE

    Guillem Carrau, Javier

    2011-01-01

    El objetivo básico de este estudio es dejar patente que el Derecho agrario de la UE es especial y autónomo. Tras el Tratado de Lisboa, el procedimiento legislativo ordinario presupone una PAC más cercana al agricultor y al medio por el incremento de

  6. Os Tratados de Polícia, fundadores da moderna saúde pública (1707-1856 Los Tratados de Policía, fundadores de la salud pública moderna (1707-1856 Treatises on Medical Police, founders of modern public health (1707-1856

    Directory of Open Access Journals (Sweden)

    Carlos Lousada Subtil

    2012-07-01

    Full Text Available A participação dos enfermeiros no movimento higienista é relativamente recente em relação aos momentos fundadores da moderna saúde pública, a que nos vamos referir. Para o enfermeiro de saúde pública contemporâneo é fundamental, no âmbito das suas atribuições e competências, analisar esses momentos à luz dum quadro conceptual que lhe permita esclarecer-se e estruturar a sua identidade profissional na construção do presente e no delinear do futuro. É objetivo deste trabalho fazer uma breve apresentação de alguns estudos sobre o tema e, sobretudo, analisar e discutir o «Tratado de Conservação da Saúde dos Povos», de Ribeiro Sanches (1756 e o «Tratado de Polícia Médica», de Freitas Soares (1818 que refletem os princípios da ciência de Polícia contidos na obra de Nicolas Delamare (1707, com recurso à metodologia de investigação histórica foucauniana. Aquelas obras ilustram bem a lenta passagem do modelo de governação corporativo para o estadualista, que se iniciou nos finais do Antigo Regime, e prosseguiu, com avanços e recuos, ao longo da monarquia constitucional inaugurada pela revolução de 1820.La participación de los enfermeros en el movimiento higienista es relativamente reciente con respecto a los momentos fundadores de la salud pública moderna a la cual vamos a referirnos. Para el enfermero actual de salud pública es fundamental, dentro del ámbito de sus atribuciones y competencias, analizar dichos movimientos a la luz de un marco conceptual que le permita aclarar y estructurar su identidad profesional en su construcción del presente y en el delinear de su futuro. El objetivo de este trabajo es realizar una breve presentación de algunos de los estudios sobre el tema y, sobre todo, analizar y discutir el «Tratado de Conservação da Saúde dos Povos», de Ribeiro Sanches (1756 y el «Tratado de Polícia Médica», de Freitas Soares (1818, que recogen los principios de la ciencia de Pol

  7. Lipid Lowering Efficacy of Pennisetum glaucum Bran in Hyperlipidemic Albino Rats

    Directory of Open Access Journals (Sweden)

    I. Javed*, B. Aslam, M. Z. Khan1, Zia-Ur-Rahman, F. Muhammad and M. K. Saleemi1

    2012-05-01

    Full Text Available The objective of the study was to determine lipid lowering efficacy of Pennisetum (P glaucum (Pearl millet, locally known as bajra, bran in hyperlipidemia albino rats. Simvastatin, (Tablet survive®, was used as cholesterol lowering synthetic drug. The period of 0-15 days was considered as a lead-in period to induce hyperlipidemia with atherogenic diet in albino rats. P. glaucum bran at dose rate of 2, 4 and 6 g/kg BW showed lipid lowering efficacy in hyperlipidemic rats at post-treatment days 30, 45 and 60. At the level of 6 g/kg, P. glaucum bran was able to produce a significant (P<0.05 increase in HDL- cholesterol (47% and fall in other lipid profile parameters i.e. total lipids (41%, triglycerides(48%, total cholesterol (39% and LDL- cholesterol (55%. P. glaucum 6 g/kg also reduced total cholesterol in liver tissue and increased fecal bile acid secretion. The results of present study suggest that 6 g/kg P. glaucum bran and 0.6 mg/kg Simvastatin were equally effective in treating hyperlipidemia in albino rats. Moreover, the potency of P. glaucum for stimulating fecal bile acid secretion in albino rats may safely be conceived, at least, as a part of mechanisms for its antihyperlipidemic efficacy.

  8. Ostracism of an albino individual by a group of pigmented catfish.

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    Ondřej Slavík

    Full Text Available Physiological and behavioural constraints hinder albino individuals. Albino animals are rare in the wild; this trait is associated with easy detection by predators, non-native or damaged environments, and exclusively aphotic environments in total darkness. The social aspect of albinism is reported only for human beings, and the effect is distinguishable in time and space when social benefits, are used to a limited the extent. Thus far, the social consequences of albinism for animals remain unknown. We used socially established groups of the pigmented catfish, (Silurus glanis, to observe space and temporal distance detachment of albino specimens in laboratory conditions. The albino fish were separated at larger distances from the group than pigmented individuals with the same social status determined by familiarity, and this asymmetry also varied in time. Albinism-related ostracism results in a solitary existence, usually followed by enhanced predation risk. The motivation for an individual's exclusion from a group appears to be the avoidance of the predation risk that increases not only for an odd individual but also for conspecifics within a group. Our findings indicate a role for albinism in behavioural processes related to sociality in a group of conspecifics.

  9. Ostracism of an albino individual by a group of pigmented catfish.

    Science.gov (United States)

    Slavík, Ondřej; Horký, Pavel; Maciak, Matúš

    2015-01-01

    Physiological and behavioural constraints hinder albino individuals. Albino animals are rare in the wild; this trait is associated with easy detection by predators, non-native or damaged environments, and exclusively aphotic environments in total darkness. The social aspect of albinism is reported only for human beings, and the effect is distinguishable in time and space when social benefits, are used to a limited the extent. Thus far, the social consequences of albinism for animals remain unknown. We used socially established groups of the pigmented catfish, (Silurus glanis), to observe space and temporal distance detachment of albino specimens in laboratory conditions. The albino fish were separated at larger distances from the group than pigmented individuals with the same social status determined by familiarity, and this asymmetry also varied in time. Albinism-related ostracism results in a solitary existence, usually followed by enhanced predation risk. The motivation for an individual's exclusion from a group appears to be the avoidance of the predation risk that increases not only for an odd individual but also for conspecifics within a group. Our findings indicate a role for albinism in behavioural processes related to sociality in a group of conspecifics. PMID:26018869

  10. Effect of Semecarpus anacardium fruits on reproductive function of male albino rats

    Institute of Scientific and Technical Information of China (English)

    ArtiSharma; PramodKumarVerma; V.RDixit

    2003-01-01

    Aim: To evaluate the effect of an ethanolic extract of Semecarpus anacardium fruits on spermatogenesis in albino rats. Methods: Male albino rats were fed with a 50 % ethanolic extract of Semecarpus anacardium fruit at 100 mg·kg-l·day-1, 200 mg·kg-l·day-1 and 300 mg·kg-1·day-1 for 60 days. Fertility test was performed after 60 days of treatment. Sperm motility and density were observed in the cauda epididymis. Biochemical and histological analyses of the blood and reproductive organs were done. Recovery of fertility was followed to evaluate the reversibility of drug action. Results: S. anacardium fruit extract administration resulted in spermatogenic arrest in albino rats. Thes perm motility and density was reduced significantly. The RBC and WBC counts, haemoglobin, haematocrit, blood sugar and urea were found to be within the normal range in the whole blood. The protein, cholesterol and glycogen in the testes and the fructose in the seminal vesicle were significantly decreased after the treatment. The fruit extract feeding caused marked reduction in the number of primary spermatocytes, secondary spermatocytes and spermatids.The number of mature Leydig cells was also decreased and degenerating cells increased proportionately. Conclusion:S. anacardium fruit extract causes spermatogenic arrest in albino rats. ( Asian J Androl 2003 Jun; 5: 121-124)

  11. Generation of Albino Cynops pyrrhogaster by Genomic Editing of the tyrosinase Gene.

    Science.gov (United States)

    Nakajima, Keisuke; Nakajima, Taeko; Yaoita, Yoshio

    2016-06-01

    Albino animals are useful for in situ hybridization experiments that demonstrate gene expression in embryos and organs, for the immunological rejection of skin grafts transplanted to host animals, and to identify tissues with regenerative ability during limbs and retina regeneration processes. Cynops pyrrhogaster has extensive regenerating capacities. To facilitate regenerative research, in the present study, we produced albino C. pyrrhogaster using genomic editing. The DNA fragment containing part of the tyrosinase gene from C. pyrrhogaster was amplified using degenerate primers corresponding to evolutionarily conserved nucleotide sequences among several species, and the nucleotide sequence was determined. We designed a transcription activator-like effector nuclease (TALEN) that targets a candidate of the C. pyrrhogaster tyrosinase gene. Fertilized eggs were injected with TALEN mRNA, and albinos of C. pyrrhogaster were obtained. The results of the present study demonstrated that TALEN can be used effectively for genomic editing in C. pyrrhogaster and that the candidates of the tyrosinase gene that were cloned by us are essential for melanin synthesis. The albino newts created in the present study can be used as versatile experimental material. PMID:27268983

  12. Distribution of 110Ag-silver nitrate prophylaxis solutions following eyedrop application to the albino rabbit

    International Nuclear Information System (INIS)

    The distribution of radioactive silver-110 labelled silver nitrate in the eye of the albino rabbit was determined by eyedrop application of 1, 2 and 6% solutions. The distribution of the radiotracer was determined at 1 h and 1 day post-application. Localization at 1 h was primarily in the cornea and conjunctiva. Washout of this radiotracer was rapid. (author)

  13. Skin cancers in albinos in a teaching Hospital in eastern Nigeria - presentation and challenges of care

    Directory of Open Access Journals (Sweden)

    Opara Kingsley O

    2010-08-01

    Full Text Available Abstract Background Albinism is a genetic disorder characterized by lack of skin pigmentation. It has a worldwide distribution but is commoner in areas close to the equator like Nigeria. Skin cancers are a major risk associated with albinism and are thought to be a major cause of death in African albinos. Challenges faced in the care of these patients need to be highlighted in order to develop a holistic management approach with a significant public health impact. The aim of the study was to determine the pattern of skin cancers seen in Albinos, and to highlight problems encountered in their management. Method Case records of albinos managed in Imo state University teaching Hospital from June 2007 to May 2009 were reviewed. The data obtained was analyzed using descriptive statistics. Results and discussion In the period under review, albinos accounted for 67% of patients managed for primary skin cancers. There were twenty patients with thirty eight (38 lesions. Sixty one percent of the patients were below 40 years. Average duration of symptoms at presentation was 26 months. The commonest reason for late presentation was the lack of funds. Squamous cell carcinoma was the commonest histologic variant. Most patients were unable to complete treatment due to lack of funds. Conclusion Albinism appears to be the most important risk factor in the development of skin cancers in our environment. Late presentation and poor rate of completion of treatment due to poverty are major challenges.

  14. Comparative analysis of transcriptomes from albino and control sea cucumbers,Apostichopus japonicus

    Institute of Scientific and Technical Information of China (English)

    MA Deyou; YANG Hongsheng; SUN Lina; XU Dongxue

    2014-01-01

    The sea cucumberApostichopus japonicus is an important economic species in China. Its dorsal body wall color is commonly tawny, whereas its ventral surface is fawn. Albino sea cucumbers are rarely observed. In order to profile gene expression and screen albinism-related genes, we compared the transcriptome of albino samples with a control by 454 cDNA sequencing. We found that 6 539 identified genes on the basis of sequence similarity to known genes were expressed in the albino A. japonicus. The gene ontology analysis indicated that the transcription of genes associated with the terms of biological regulation and pigmenta-tion was non-abundant in the albino library compared to the control. Based on an analysis using the Kyoto Encyclopedia of Genes and Genomics (KEGG) database, we identified 14 important genes that were in-volved in major intercellular signaling pathways related to melanin synthesis, such as tyrosine metabolism, the mitogen-activated protein kinase (MAPK) pathway, and melanogenesis. The expressions of fibroblast growth factor receptor 4 (FGFR4), protein kinase C (PKC), protein kinase A (PKA), and Ras genes were sig-nificantly down-regulated in the albino transcriptome compared with the control, while the expressions of homogentisate 1, 2-dioxygenase gene (HGO), cAMP-responsive element binding protein (CREB), transcrip-tion factor AP-1(c-jun), and calmodulin (CaM) were significantly up-regulated (Fisher's exact test,p < 0.05). These differentially expressed genes could be candidate genes for revealing the mechanism of albinism and investigating regulation of melanin synthesis inA. japonicus.

  15. QUANTITATIVE AND HISTOCHEMICAL STUDY ON THE ADRENAL MEDULLA IN POST NATAL PERIOD OF ALBINO RAT

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    Wagieh k.Baiomy; Abdel-mawgood Anas; Mamdooh Ghaly; Ashraf M. Moustafa

    2009-09-01

    Full Text Available Background: The present work was based on the evaluation of histological, histochemical, and quantitative study on the adrenal medulla of the white albino rat in the different post natal age period. Material and methods:Sixty male albino rats were used in this study. The rats were classified to 4 main groups as follows: - Group one : One week old albino rats. - Group two: One month old albino rats. - Group three: Three months old albino rats. - Group four: Senile rats. Three main parameters were performed in this study, the first was the study of the morphological changes in the adrenal medulla in the different postnatal age groups. The second was concerned with the histochemical studies while the last parameter was the quantitative studies on the gland volume as well as its cellular count. These three parameters were performed by using different staining techniques. Results: The results showed that medullary cells in the early age groups were arranged in non-differentiated groups and become more differentiated in the older age groups. Both reticular and elastic fibers in the older age groups showed a definite increase especially at the region of corticomedullary zone. The different types of chromaffin cells were more observed at the old age groups. The concentration of ascorbic acid granules was more marked in the senile group. The quantitative changes were in the form of increased medullary volume especially in the old age. The number of chromaffin cells as well as the concentration of ascorbic acid contents was more noticed in the old age group. Conclusions: The differentiation of both divisions of the adrenal gland was not noticed in the early age groups. Cellular and fibrous differentiations were more seen in older age groups which may reflects an idea about the degree of gland maturation

  16. Analysis of the albino-locus region of the mouse. I. Orgin and viability

    International Nuclear Information System (INIS)

    Numerous specific-locus experiments designed to test the mutagenic effect of external radiation have yielded, in over 3,600,000 animals observed, altogether 119 presumed mutations involving the c locus. Of these, 55 were viable and albino (c/sup av/), 13 were viable and of various intermediate pigment types (c/sup xv/), four were subvital (c/sup as/ and c/sup xs/), seven were neonatally lethal albinos (c/sup al/), 28 prenatally lethal albinos (c/sup al/); 12 died untested. All of the prenatally lethal and at least one of the neonatally lethal c-locus mutations (c/sup al/ classes) are probably deficiencies that we have analyzed extensively in other experiments. Since absence of the locus mimics albino in phenotype, the intermediates (c/sup xv/ and c/sup xs/ groups) probably resulted from intragenic changes. The class of viable albino mutants (c/sup av/) might include, in addition to intragenic changes, some extremely small deficiencies. The effects on viability of c-locus lethals (c/sup al'/s) in heterozygous condition are not drastic enough to be perceived in stocks of mixed genetic background except in the case of the two longest known deficiencies and a few others. Analysis of the relation between radiation treatment and type of c-locus mutants obtained shows that the relative frequency of viable mutations, for each germ-cell type, is greater for low-LET than for neutron irradiation; however, the difference for any individual cell type is not significant. The majority (66.7%) of mutations derived from x- or γ-ray irradiated spermatogonia are viable, and the proportion of ''intermediates'' among these viables is similar to that among presumed spontaneous c-locus mutations

  17. Hematological and Histological Response of Wister Albino Rat Rattus norvegicus a Dietary Supplement of Seaweed Diet Gracilaria edulis

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    T. Anbalagan

    2009-10-01

    Full Text Available A dietary supplementation of seaweed Gracilaria edulis haematological and histological responseof albino rat Rattus norvegicus .The blood protein, cholesterol, albumin, calcium, phosphorus and urea of theseaweed feed albino rats having an increased tendency during the experimentation when compared with controlrats. Its note mostly that the experimental rat showing a decreasing level of glucose when compared withcontrol rats. The oral picture of the haematological change of albino rat fed with seaweed diet evidenced theiractive participation on the metabolism of the experimental subject. These findings w ere well correlated w ithhistological observation in the liver and intestine shows the hepatocyte appearance and deposited fat and fociat necrosis is also seen in photomicrographs.

  18. Moving on from NAFTA to the FTAA?: the impact of trade agreements on social and health conditions in the Americas ¿Del TLCAN al ALCA?: el impacto de los tratados comerciales sobre la situación social y económica de las Américas

    OpenAIRE

    Miguel San Sebastián; Anna-Karin Hurtig

    2004-01-01

    Gracias a los tratados comerciales internacionales, el comercio mundial y la inversión extranjera se han incrementado vertiginosamente en los últimos 25 años. Es preciso, entonces, examinar las pruebas acumuladas de que el comercio tiene un efecto sobre la salud e incorporarlas en el proceso de formulación de políticas. Uno de los acuerdos en actual proceso de negociación es el Área de Libre Comercio de las Américas (Free Trade Agreement of the Americas,o ALCA). Con el fin de ayudar a evaluar...

  19. Um albino parcial de veado campeiro (Ozotoceros bezoarticus, Linnaeus no Parque Nacional das Emas, Goiás Partial albinism in the pampas deer and a critical analysis about albino Mammals

    Directory of Open Access Journals (Sweden)

    Flávio H.G. Rodrigues

    1999-01-01

    Full Text Available A case of partial albinism in the pampas deer, recorded at the Emas National Park, Goiás, Brazil is described. The coat color and behaviour of the albino are compared with normal pampas deer.

  20. MORFOLOGIA DO TIMO DE COELHOS NOVA ZELÂNDIA BRANCO TRATADOS COM GENTAMICINA

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    Matheus Henrique Magalhães Silva

    2013-06-01

    Full Text Available Considering the thymus importance for the immune system and the immunodepressive potential of gentamicin, this study aimed to evaluate the effects of this aminoglycoside on the thymus histology of New Zealand White rabbits. For this, it were used 20 adult rabbits, 10 males and 10 females with a mean weight of 2.5 kg, healthy, of the New Zealand White breed, which were divided into two groups (control and treated, with five males and five females each. After seven days of daily treatment with 4.4 mg/kg of gentamicin by subcutaneous injection, on the eighth day the animals were sacrificed and their thymuses, after collected, were fixed in Bouin solution for 24 hours and processed routinely for embedded in paraffin. After the semi-serial microtome with thickness of 5 µm at intervals of 1000 µm, the histological sections were stained using Masson’s Trichrome techniques. It were analyzed, by light microscopy, the morphological characteristics of cortical and medullary of thymic individualized lobes of these sections. It was not observed histological differences between sexes or between control and treated groups. The results showed that this antibiotic, used in therapeutic dosage and by the recommended period, did not alter the morphology of the thymus of treated animals.Considerando-se a importância do timo para o sistema imunológico e o potencial imunodepressor da gentamicina, este estudo objetivou avaliar os efeitos deste aminoglicosídeo sobre a histologia do timo de coelhos da raça Nova Zelândia Branco. Para isto, utilizou-se 20 coelhos adultos, 10 machos e 10 fêmeas, com peso médio de 2,5 kg, hígidos, da raça Nova Zelândia Branco, os quais foram divididos em dois grupos (controle e tratado com cinco machos e cinco fêmeas cada. Após sete dias de tratamento diário com 4,4 mg/kg de gentamicina por via subcutânea, no oitavo dia, os animais foram sacrificados e seus timos, após coletados, foram fixados em solução de Bouin por 24

  1. Prevalencia, factores de riesgo y características patogénicas diferenciales de EPOC y enfisema en pacientes con infección VIH

    OpenAIRE

    Sampériz Abad, Gloria; Riera Jaume, Melcior; Marín Trigo, José María

    2014-01-01

    Antecedentes: Las anomalías pulmonares están a menudo presentes en pacientes infectados con el virus de la inmunodeficiencia humana (VIH). Objetivos: Determinar la prevalencia, las características patogénicas y los factores de riesgo de anormalidades pulmonares en pacientes VIH +. Métodos: Se incluyeron en el estudio 275 pacientes VIH +, con una media (± desviación estandar) de edad de 48,5 (± 6,6) años y en su mayoría (95,6%) tratados con terapia antirretroviral de gran actividad (TARGA), Se...

  2. Studies on the hypolipidemic effects of Coconut oil when blended with Tiger nut oil and fed to albino rats

    Directory of Open Access Journals (Sweden)

    El-Anany, A. M.

    2012-09-01

    Full Text Available Hyperlipidemia is a predominant risk factor for atherosclerosis and associated cardiovascular diseases (CVD. The international guidelines issued by the World Health Organization recommend a reduction in dietary saturated fat and cholesterol intake as a means to prevent hypercholesterolemia and CVD. The main objective of the current investigation was to evaluate the effects of feeding blended oils consisting of coconut oil (CNO with different proportions of Tiger nut oil (TNO on serum lipid levels in Albino rats. GLC analysis was performed to illustrate the fatty acid composition of the blended oils. Blended oils were obtained by mixing tiger nut oil with coconut oil at the volume ratios of 100:0, 70:30, 50:50, 25:75, 10:90 and 0:100. Fifty-six male albino rats were randomly divided into 7 groups of 8 rats each according to the oil type. The blended oils were fed to rats for a period of up to 10 weeks. Total cholesterol (T-Ch, high-density lipoprotein cholesterol (HDL-Ch, low-density lipoprotein cholesterol (LDL-Ch, and triglycerides (TG, were determined. The atherogenic Index (AI was calculated. The results showed that non-significant changes in all nutritional parameters were observed between the control group and the rats fed with the tested oils. The results also indicate that coconut oil had 86% saturated fatty acids. On TNO contains 66% oleic acid. Therefore, blending coconut oil with tiger nut oil can reduce the proportions of saturated to unsaturated fatty acids in CNO. The rats that were fed blended oils showed significantly reduced levels of serum cholesterol as compared to those fed CNO. The HDL levels were marginally enhanced in the rats that were fed blended oils. The total cholesterol and LDL cholesterol levels were controlled when TNO/CNO proportions varied between 25/75 and 70/30. This was reflected in the calculation of the atherogenic index. Similar changes were observed with serum triglyceride levels.

    La hiperlipidemia

  3. Transportación ósea en defectos masivos de la tibia con fijador externo RALCA

    OpenAIRE

    Mario Milanés Castellanos; Juan Vicente Quezada Musa; Eraclio Delgado Rifá

    2014-01-01

    Se presenta un paciente masculino, de 20 años de edad, que sufrió una fractura expuesta de la tibia derecha, grado II, el cual fue tratado, según el protocolo de urgencia, con la aplicación de antibióticos, desbridamiento, colocación de osteosíntesis interna mediante una placa de compresión y cobertura cutánea de la fractura. Se comenzó a observar una evolución desfavorable, con enrojecimiento de la piel y sepsis local mantenida, a pesar de desbridamientos repetidos y antibioticoterapia, lo ...

  4. La osteosíntesis con placa volar como tratamiento de las fracturas complejas del radio distal

    OpenAIRE

    Arenas Planelles, Antonio; Ortega Arruti, J.A.; Corchuelo Maíllo, C.; Arenas Miquélez, A.; Ortega Sáez, M. (Marta)

    2006-01-01

    Se presentan 45 casos de fractura compleja del radio distal tratados mediante reducción abierta y osteosíntesis con placa palmar. Los resultados fueron satisfactorios en 42 casos (93,3 %), con pocas complicaciones durante su evolución 45 cases of complex fracture of the distal radius are presented. They were treated by open reduction and stable fixation with a volar plate. The results were satisfactory in 42 cases (93,3 %), with few complications during their evolution.

  5. Tratamiento de alteraciones funcionales y dentomaxilofaciales con el método de Fränkel

    OpenAIRE

    Romero Zaldivar, Esperanza C.

    1997-01-01

    Se realizó un estudio descriptivo en 22 pacientes tratados con los reguladores de función de Fränkel para determinar los resultados de tratamiento mediante este método, los que se seleccionaron de acuerdo con la clasificación de síndromes planteada por Moyers y que presentaban dentición mixta, en las edades comprendidas de siete a nueve años. El grupo original estuvo constituido por 55 pacientes que ingresaron en el servicio de Ortodoncia de la Clínica Estomatológica Docente La Vigía desde j...

  6. Glosectomía parcial reconstruida con colgajo libre del radial. Propuesta de tratamiento fisioterápico

    OpenAIRE

    Almeida Santamaría, Mercedes

    2013-01-01

    El carcinoma escamoso de la lengua en estadio avanzado que es tratado quirúrgicamente con glosectomía reconstruida con colgajo libre del radial, resección de ganglios linfáticos afectados y radioterapia va a ocasionar secuelas en diferentes áreas corporales: lengua, columna cervical y miembro superior, afectándose el recorrido articular, la fuerza muscular, la sensibilidad táctil, la flexibilidad de los tejidos blandos y el drenaje linfático. El planteamiento de un tratamiento fisioterápico b...

  7. Logros en educacion secundaria y su relacion con inteligencia y con resolucion de problemas nuevos

    Directory of Open Access Journals (Sweden)

    Nuria Cortada de Kohan

    1998-01-01

    Full Text Available En esta investigación, que es una segunda parte de la ya presentada en esta Revista Latinoamericana de Psicología. Vol. 29, N° 1, 1997, hemos tratado de profundizar en la relación entre procesos de pensamiento, inteligencia general y logros en educación. Hemos utilizado un proyecto metodológicamente similar al usado con los alumnos primarios elaborando tests de conocimientoadhoc para alumnos del último año de la Escuela Secundaria. Asimismo hemos aplicado a la misma muestra de 200 alumnos aproximadamente el Test de las Matrices Progresivas de Raven, Forma Avanzada, y hemos utilizado 5 problemas para analizar las estrategias de pensamiento de los creados por Rimoldi para resolución de problemas nuevos. Los resultados, de manera similar con Jo que ocurrió en la muestra de alumnos primarios, nos permite concluir que decididamente la escuela no parece aprovechar debidamente los recursos intelectuales de los jóvenes. y esto avala las ideas de muchos pensadores actuales que consideran que los sistemas usuales de enseñanza deben ser drásticamente modificados.

  8. Improvement of sperm density in neem-oil induced infertile male albino rats by Ipomoea digitata Linn

    OpenAIRE

    Ghanashyam Keshav Mahajan; Raghunath Totaram Mahajan; Mahajan, Arun Y.

    2015-01-01

    Aim: Investigation has been carried out to validate folkloric claim of the potential of ID based on reproductive health status in experimentally induced male albino rats. Materials and Methods: Emulsified neem oil (ENO) fed albino rats were orally administered root powder of ID suspended in water for the doses of 250 and 500 mg/kg body weight for 40 days. Change in organ weight, sperm density and motility, serum hormonal levels and histomorphological changes were evaluated. Results: Significa...

  9. Effects of Crude Extract of Ageratum Conyzoides, Moringa Oleifera and Zanthoxylum Zanthoxyloides on Serum Lipid Profile in Albino Rats

    OpenAIRE

    OYEWOLE O.I.; ADEBAYO A.G.; OGUNSAKIN S.M

    2012-01-01

    Ageratum conyzoides, Moringa oleifera and Zanthoxylum zanthoxyloides are among medicinal plants commonly used in African folk medicine as remedies for the treatments of high blood pressure and heart related diseases. This study was carried out to compare the effects of Ageratum conyzoides, Moringa oleifera and Zanthoxylum zanthoxyloides extracts on serum lipid profile in albino rats. Thirty five albino rats were grouped into seven each containing five rats. Control rats (Group 1) received dis...

  10. Lead acetate toxicity on glucose level and liver enzymes ameliorated by camel's milk in wistar albino rat

    OpenAIRE

    Draid, Marwan M.; Mujahed O. Bushwereb; Shadia G. Ramadan

    2016-01-01

    Background: The present work was conducted to investigate the effects of lead acetate intoxication on glucose and liver functions in albino rats, and the possible effectiveness of using camel milk to protect against lead induced toxicity. Methods: Eighteen male albino rats were divided into three groups of six, the first was a control group, the second received orally lead acetate in water as (2 ml saline containing 5 mg/kg body weight of lead acetate) and the third received the same ...

  11. Hepatoprotection: A Hallmark of Citrullus colocynthis L. against Paracetamol Induced Hepatotoxicity in Swiss Albino Rats

    OpenAIRE

    Suresh Kumar Bansal; Ramesh Chandra Saxena; Arshed Iqbal Dar

    2012-01-01

    Objective: To demonstrate the in-vivo hepatoprotective effect of the ethanolic extracts of Citrullus colocynthis (Linn.) against paracetamol induced hepatotoxicity in albino rats. Animal Model: Swiss Albino rats of either sex were used, divided into six groups with six in each group. Group 1-Normal control: The animals were maintained under normal control, which were given distilled water only. Group 2-Induction of hepatotoxicity: The animals received par...

  12. Las aspiraciones cosmpolitas de la ciudadanía europea a la luz del Tratado de Lisboa

    OpenAIRE

    Jose Antonio García Saez

    2010-01-01

     En octubre de 2009 se repetirá el referéndum irlandés sobre el Tratado de Lisboa. El accidentado proceso de gestación de este tratado, heredero a su vez de la non nata Constitución Europea, suscita algunas dudas en torno a la concepción de ciudadanía europea que vienen manejando las instituciones de la UE. En el presente artículo se intentará aportar algunos elementos de reflexión sobre esta concepción de ciudadanía tomando como referencia el ideal más amplio de la ciudadanía cosmopolita. Pa...

  13. Derecho aplicable al fondo de la controversia en arbitrajes surgidos de tratados de inversión

    Directory of Open Access Journals (Sweden)

    Francisco Endara Flores

    2011-07-01

    Full Text Available En este trabajo se analizará cuál es el derecho aplicable al fondo de la controversia de un arbitraje surgido de un Tratado de Inversiones. A lo largo del artículo se tratará de demostrar que la fuente primaria aplicable al fondo de la controversia, será el mismo Tratado de Inversión, seguido por un análisis del rol que tendrá el derecho local al momento de resolver la controversia.Lo mismo se hará respecto al resto de normas del derecho internacional y la manera en como dichas normas se integran para ser aplicadas por los árbitros al momento de resolver la controversia.

  14. Sífilis secundaria en un paciente viviendo con VIH

    Directory of Open Access Journals (Sweden)

    Mauricio La Rosa

    2007-07-01

    Full Text Available Se presenta el caso de un paciente varón de 31 años, con diagnóstico de infección por el virus de inmunodeficiencia humana (VIH sin tratamiento antirretroviral, presentó lesiones ulcerativas en la región genital que luego progresaron por todo el cuerpo, se le diagnosticó sífilis secundaria. Fue tratado con penicilina benzatínica, con lo cual las lesiones desaparecieron. Se discute las pruebas diagnósticas realizadas y la terapéutica empleada. La coinfección por Treponema pallidum y por el VIH está presente en la población general y en especial en poblaciones de riesgo, como los hombres que tienen sexo con hombres y clientes de trabajadoras sexuales, esta situación puede afectar la presentación inicial así como el curso de la enfermedad.

  15. Hemangioma infantil tratado com propranolol Propranolol treatment for hemangioma of infancy

    Directory of Open Access Journals (Sweden)

    Flavia Kakiuti Bonini

    2011-08-01

    Full Text Available O hemangioma infantil é o tumor mais comum da infância, com grande variabilidade de apresentação clínica. A maioria das lesões regride espontaneamente e o tratamento está indicado para casos específicos que possam gerar ulceração, disfunção ou desfiguração. O tratamento baseia-se, principalmente, no uso de corticosteroides, seja por via sistêmica, tópica ou intralesional. Recentemente, o propranolol foi descrito como nova opção terapêutica para os hemangiomas, com resultados satisfatórios, permanentes e menos efeitos indesejáveis que os corticosteroides. É relatado o caso de uma criança com hemangioma periorbital e frontoparietal extenso, tratado com propranololInfantile hemangioma or hamangioma of infancy is the most common tumor in children, with great variability of presentation. Most cases resolve spontaneously and treatment is usually indicated for specific cases where injury has a high rate of morbidity or disfigurement after regression. The treatment is based on the use of systemic corticosteroids, which can also be used topically or by intralesional injections. Propranolol has been used recently as a new therapeutic option for the treatment of hemangiomas, with satisfactory, permanent results and fewer adverse effects than corticosteroids. This is a report of the case where a child presenting extensive periorbital and frontoparietal hemangioma was treated with propranolol

  16. El individuo ante la biopolítica: Tratado de Libre Comercio Colombia-EE.UU.

    Directory of Open Access Journals (Sweden)

    Martha Isabel Gómez Lee

    2009-11-01

    Full Text Available El problema de las patentes de biotecnología puede ser visto como un asunto de política de ciencia y tecnología, en la que el contexto de la globalización y de la sociedad del conocimiento cruza la política de la vida o biopolítica. En los Estados Unidos se considera un asunto de política pública del conocimiento, mientras que en Colombia es una cuestión de política social y ambiental. Los ciudadanos colombianos tienen mucho que decir y controlar en la revolución biotecnológica y comercial que redimensiona la extracción de renta de la tierra y reconfigura a la biodiversidad colombiana como nueva renta de germoplasma global. Los individuos están llamados a actuar de manera creativa en tres dimensiones: como agentes políticos y fuente de razones y acciones políticas, como objetivo último de las decisiones y las acciones de la biopolítica y como interfase entre las políticas públicas globales y las sociales. En esta última dimensión, el individuo colombiano es un actor político fundamental en las negociaciones del Tratado de Libre Comercio entre Estados Unidos y Colombia por ser él un actor activo de la sociedad civil en defensa de la vida.

  17. Legitimidad y finalidad de los capítulos de propiedad intelectual en los tratados de libre comercio (TLC

    Directory of Open Access Journals (Sweden)

    Susy Frankel

    2011-11-01

    Full Text Available Una visión analítica de la realidad actual permite apreciar un auge de los Tratados de Libre Comercio, mientras se presenta un estancamiento en las negociaciones multilaterales de comercio. Si bien la negociación de los TLC no se limita a los países desarrollados, los negociados por los países en desarrollo no tienden a contemplar mejoras en los estándares de propiedad intelectual. Algunos de los capítulos relativos a la propiedad intelectual incluidos en los Tratados de Libre Comercio simplemente reafirman los estándares del acuerdo sobre los ADPIC, mientras que otros se orientan a ampliar el cubrimiento y alcance de los derechos internacionales de propiedad intelectual. El presente artículo se concentra en estudiar la legitimidad y la finalidad de los capítulos de propiedad intelectual en los Tratados de Libre Comercio, así como la relación entre los capítulos sobre propiedad intelectual y el sistema multilateral de la Organización Mundial del Comercio (OMC que facilita los TLC y los límites racionales de la propiedad intelectual en el contexto comercial.

  18. EFFECT OF METHANOLIC EXTRACT OF SWEET CORN SILK ON EXPERIMENTALLY INDUCED HYPERTHYROIDISM IN SWISS ALBINO RATS

    Directory of Open Access Journals (Sweden)

    Thoudam Bhaigyabati

    2012-03-01

    Full Text Available Plant materials have been used as medicine for a wide variety of human ailments due to increase in cost of treatment, side effects of several allopathic drugs and development of resistance to currently used drugs for infectious diseases. In the present study, hyperthyroidism was induced to male Swiss albino rats orally using thyroxine for 14 days. The impact of methanolic extract of sweet corn silk in different concentrations (200, 300 & 400mg/kg for 21 days was assessed in these animals. The serum was analyzed for thyroid hormone level and lipid profile before and during the experiment. Results showed that 400mg/kg concentration of methanolic extract has the highest effectiveness which is equal to that of standard drug to revert the hyperthyroid condition in Swiss albino rats and were confirmed with the histopathological study of the thyroid gland.

  19. ANTIEPILEPTIC ACTIVITY OF THE WHOLE PLANT EXTRACTOF MELISSA OFFICINALIS IN SWISS ALBINO MICE

    Directory of Open Access Journals (Sweden)

    Jalal Uddin Bhat et al.

    2012-03-01

    Full Text Available Epilepsy is a neurological disorder characterized by unprovoked, recurring seizures that disrupt the nervous system and can cause mental and physical dysfunction. Based on the ethnopharmacological information of the plant, the methanol and aqueous extract of the whole plant of MELISSA OFFICINALIS was evaluated for its antiepileptic activity in Swiss Albino Mice .Antiepileptic activity was assessed by using MES and PTZ induced models (250 and 500 mg/kg. Body weight doses were used for the present study. In the MES model the methanol and aqueous extracts showed a dose dependent reduction in the duration of hind limb extensor phase. In pentylenetetrazole induced model methanol and aqueous extracts at dose level of 500mg/kg body weight showed significant reduction in the tonic convulsions induced by PTZ when compared with control group. The results suggest a possible anticonvulsant effect of the methanol and aqueous extracts of Melissa officinalis in Swiss Albino Mice.

  20. EFFECTS OF POTASSIUM BROMATE ON THE KIDNEY AND HAEMATOLOGICAL PARAMETERS OF SWISS ALBINO MICE

    Directory of Open Access Journals (Sweden)

    MARIA STUTI

    2013-01-01

    Full Text Available The present study aimed to investigate the possible effects of potassium bromate toxicity on histological,haematological and biochemical parameters in Swiss albino mice. Mice were orally administered with potassiumbromate at the rate of 150 mg/kg body weight daily in a single dose for 30, 60 and 120 days. The chemicalsignificantly reduced the RBC count (p<0.01 Hb% (p<0.01 and platelet count (p<0.01, while it increasedsignificantly the urea (p<0.01 and creatinine level (p<0.01 and decreased total protein and Albumin (p<0.01Histopathological examination showed degenerative changes of tubular cells, cytoplasma vacuolation, cellularinfiltration, tubular dilation with eosinophilic debris and clear cell cytoplasm were observed. These findingssuggest that KBrO3 affects the physiological and biochemical activities of Swiss albino mice

  1. Antiovulatory and estrogenic activity of Plumbago rosea leaves in female albino rats

    OpenAIRE

    Sheeja E; Joshi S; Jain D

    2009-01-01

    Objective : To evaluate the effect of petroleum ether (60-80), chloroform, acetone, ethanol and aqueous extracts of Plumbago rosea leaves on the estrous cycle and to identify the estrogenic activity of active acetone and ethanol extracts in female albino rats. Methods : Plant extracts were tested for their effect on the estrous cycle at two dose levels: 200 and 400 mg/kg, respectively. The effective acetone and ethanol extracts were further studied on estrogenic activity in rats. Histologica...

  2. Antiovulatory and estrogenic activity of Plumbago rosea leaves in female albino rats

    OpenAIRE

    Sheeja, E.; Joshi, S.B.; D. C. Jain

    2009-01-01

    Objective: To evaluate the effect of petroleum ether (60–80°), chloroform, acetone, ethanol and aqueous extracts of Plumbago rosea leaves on the estrous cycle and to identify the estrogenic activity of active acetone and ethanol extracts in female albino rats. Methods: Plant extracts were tested for their effect on the estrous cycle at two dose levels: 200 and 400 mg/kg, respectively. The effective acetone and ethanol extracts were further studied on estrogenic activity in rats. Histological ...

  3. Effect of nigella sativa seeds extract on serum c-reactive protein in albino rats

    International Nuclear Information System (INIS)

    C-reactive protein (CRP) is an acute phase protein. It predicts future risk of cardiovascular diseases. Different medicinal plants and their active ingredients possess the ability to reduce serum CRP levels and hence inflammatory disorders and cardiovascular diseases. In our study, ethanolic extract of Nigella sativa seeds was evaluated in albino rats for its possible effect on serum CRP levels. Objective: The objective of this study was to determine the effect of ethanolic extract of Nigella sativa seeds on an acute inflammatory biomarker/mediator, C-reactive protein (CRP) in albino rats. Study Design: Randomized controlled trial (RCT). Place and Duration of Study: Physiology Department, Services Institute of Medical Sciences (SIMS), Lahore; from September to November, 2009. Subjects and Methods: The study was carried out on 90 male albino rats. Five percent (5%) formalin in a dose of 50 meu1 was injected into sub-plantar surface of right hind paw of each rat to produce inflammation. The rats were randomly divided into three groups of thirty each. Group A was given normal saline (control); group B was given Nigella sativa seed extract; and group C received diclofenac sodium, as a reference drug. CRP levels in each group were measured from blood samples taken 25 hours after giving formalin. Results: The ethanolic extract of Nigella sativa seeds, given intraperitoneally, caused highly significant (p<0.001) reduction in serum CRP levels as compared to control group. The reduction in CRP levels by ethanolic extract of Nigella sativa was also significantly (p<0.05) more than that produced by diclofenac sodium. Conclusion: Our results suggest that Nigella sativa possesses ability to reduce serum CRP levels significantly, after production of artificial inflammation, in albino rats. (author)

  4. EFFECT OF AMLODIPINE ON ORAL GLUCOSE INDUCED GLYCEMIC CHANGES IN NORMAL ALBINO RATS

    OpenAIRE

    Dr. Sushma V. Naidu et al

    2012-01-01

    Objective: To determine the effect of amlodipine on blood glucose levels through oral glucose tolerance test in normoglycemic albino Rats and the magnitude of its effect on basal v/s glucose induced glycemic value compared to control.Methods: Rats were divided into control and test groups to study the effect of glucose induced glycemic changes in normal rats following oral administration of amlodipine. The control group received 1 ml of distilled water everyday, test group received amlo...

  5. Evaluation of the aphrodisiac activity of Tribulus terrestris Linn. in sexually sluggish male albino rats

    OpenAIRE

    Surender Singh; Vinod Nair; Yogendra K Gupta

    2012-01-01

    Objectives: To study the effect of acute and repeated dose administration of lyophilized aqueous extract of the dried fruits of Tribulus terrestris (LAET) on sexual function in sexually sluggish male albino rats. Materials and Methods: Aphrodisiac activity of the test drug was evaluated in terms of exhibited sexual behavior. In order to assess the effect of chronic T. terrestris exposure on the hypothalamus--pituitary--gonadal axis, testosterone level estimation and sperm count were carried o...

  6. Evaluation of the potential carcinogenic action of radiocalcium internal irradiation in Swiss albino mice

    International Nuclear Information System (INIS)

    The carcinogenic action of 45Ca on inducing hepatocelluar carcinoma (HCC) in Swiss albino mice has been statistically evaluated. HCC proved to be radiation-induced and not due to spontaneous origin. Also, the higher incidence of male hepatocarcinogenesis due to internal irradiation has been found to be significant. The precise possible mechanism regarding the higher male susceptibility to liver cancer has been discussed in the light of available literature. (author)

  7. WOUND HEALING ACTIVITY OF FLAVONOID FRACTION OF CYNODON DACTYLON IN SWISS ALBINO MICE

    OpenAIRE

    M. Saroja; Santhi, R; S. ANNAPOORANI

    2012-01-01

    The aim of the present study is to evaluate the wound healing activity of flavonoid fraction of Cynodon dactylon in swiss albino mice. The wound healing property of the fraction was studied in excision wound which was inflicted by cutting away 0.5cm standard full thickness of wound was created on the predetermined dorsal area. The flavonoid fraction of Cynodon dactylon were applied externally daily on the excised wound area for 8 days. This fraction facilitates the healing process as evidence...

  8. Genotoxic and histotoxic effects of air pollutants at a benzene station on albino rats

    OpenAIRE

    Mohamed Abousalem; Amer Elgerwi; Abdel Baset El-Mashad

    2014-01-01

    Background: This study was designed to explore the hazardous effects of occupational exposure to air pollutants arising from benzene stations. Methods: A total of 48 albino rats were divided into three groups each of sixteen animals. Groups-I and II were kept at a benzene station for 60 and 120 days, respectively; while group-III was kept as a control under normal laboratory conditions. At the end of the experiment, animals were sacrificed and bone marrow samples were taken to investigate ...

  9. PRELIMINARY PHYTOCHEMICAL ANALYSIS AND ACUTE ORAL TOXICITY STUDY OF MUCUNA PRURIENS LINN. IN ALBINO MICE

    OpenAIRE

    Deka Manalisha; Kalita Jogen Chandra

    2012-01-01

    Mucuna Pruriens Linn. is an annual, climbing shrub which has an important place among aphrodisiac herbs in India since the ancient times. The plant has been using traditionally for many medicinal purposes such as Infertility, Parkinson’s disease, Loss of libido, Antioxidant, Anti venom, Anti microbial etc. The present study was carried out to investigate the preliminary phytochemical analysis and acute oral toxicity of the seeds of M.pruriens on albino mice. Matured seeds of M.pruriens were d...

  10. Toxicity assessment of ethanol extract of Solanum villosum (Mill) on wistar albino rats.

    OpenAIRE

    Venkatesh R; Kalaivani K; Vidya R

    2014-01-01

    Purpose: To evaluate the potential toxicity of ethanol extract of the medicinal plant Solanum villosum (Mill). Methods: Ethanol extract of S. villosum administered orally at ranges of doses 100, 200, 400, 600 and 800 mg/kg/bw to assess its impact on biochemical indices of Wistar albino rats. Hematological profile, biochemical assays, antioxidant and lipid peroxidation assays were compared between control and experimental animals. An acute toxicity test was performed in rats at different co...

  11. Histopathological effects of pesticide-cholopyrifos on kidney in albino rats

    OpenAIRE

    Rekha; Sunanda Raina; Sajad Hamid

    2013-01-01

    Background: Histopathological lesions have been widely used as biomarkers for health evaluation of organism exposed to pollutants and can be used as warning symptoms for organism health. There are few reports regarding histomorphological changes in kidney following pesticide chlorpyrifos exposure which has prompted us to undertake this study. Methods: The present study was conducted on 45 inbred adult Wistar albino rats of either sex, weighing 145 – 165 gms. These animals were randomly d...

  12. Protective Effect of Rosemary (Rosmarinus Officinalis) Extract on Naphthalene Induced Nephrotoxicity in Adult Male Albino Rat

    OpenAIRE

    Neveen M. El-Sherif; Noha Mohy Issa

    2015-01-01

    Background: Naphthalene (NA) is a common environmental contaminant and is abundant in tobacco smoke. Rosemary (Rosmarinus officinalis) is a herb commonly used as a spice and flavoring agents in food processing and is useful in the treatment of many diseases. Aim of the work: To study the nephrotoxicity of NA and to evaluate the possible protective role of rosemary extract in adult male albino rat. Materials and Methods: 25 animals were divided into three groups: Group I (Control group), G...

  13. The genome sequencing of an albino Western lowland gorilla reveals inbreeding in the wild

    OpenAIRE

    Prado-Martinez, Javier; Hernando-Herraez, Irene; Lorente-Galdos, Belen; Dabad, Marc; Ramirez, Oscar; Baeza-Delgado, Carlos; Morcillo-Suarez, Carlos; Alkan, Can; Hormozdiari, Fereydoun; Raineri, Emanuele; Estellé, Jordi; Fernandez-Callejo, Marcos; Valles, Mònica; Ritscher, Lars; Schöneberg, Torsten

    2013-01-01

    Background The only known albino gorilla, named Snowflake, was a male wild born individual from Equatorial Guinea who lived at the Barcelona Zoo for almost 40 years. He was diagnosed with non-syndromic oculocutaneous albinism, i.e. white hair, light eyes, pink skin, photophobia and reduced visual acuity. Despite previous efforts to explain the genetic cause, this is still unknown. Here, we study the genetic cause of his albinism and making use of whole genome sequencing data we find a higher ...

  14. HEPATOPROTECTIVE ROLE OF SODIUM SELENITE AGAINST OXIDATIVE DAMAGE INDUCED BY MERCURIC CHLORIDE IN RAT ALBINOS WISTAR

    OpenAIRE

    Youcef Necib; Ahlem Bahi; Sakina Zerizer; Cherif Abdennour; Mohamed Salah Boulakoud

    2013-01-01

    Background: The present study was undertaken, to evaluate the protective effect of sodium selenite against mercuric chloride induced oxidative stress in experimental rats. Female Albinos Wistar rats randomly divided into four groups, were the first was served as a control, whereas the remaining groups respectively treated with: sodium selenite (1mg/ kg b.w; ip), mercuric chloride (1 mg/kg body weight i.p) and combination of sodium selenite and HgCl2. Change in liver enzyme activities, thiobar...

  15. Analysis of inorganic elements in blood of albino rabbit using NAA

    Energy Technology Data Exchange (ETDEWEB)

    Metairon, Sabrina; Zamboni, Cibele B.; Medeiros, Ilca M.M.A., E-mail: metairon@live.co [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2009-07-01

    In this work Br, Cl, K and Na concentrations in albino rabbit blood were determinate using NAA. They are the first indicative interval for reference values in whole blood and they could be used for checking the clinical status of this specie when it will be used was animal model. The results when compared with human whole blood estimation suggest compatibility for Br, Cl and K considering 95% of confidence interval but, for Na the levels are altered, suggesting physiologic differences. (author)

  16. Effect of Aqueous Flower Extract of Catharanthus roseus on Alloxan Induced Diabetes in Male Albino Rats

    OpenAIRE

    Natarajan, A.; K. Syed Zameer Ahmed; Sundaresan, S.; A. Sivaraj; Devi, K; B Senthil Kumar

    2012-01-01

    Catharanthus roseus is widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus. The present study was carried out to investigate the antidiabetic and hyperlipidemic potential of Catharanthus roseus on alloxan induced diabetes in male albino rats. Oral administration of aqueous extract of Catharanthus roseus at a dose of 250 mg, 350 mg, and 450 mg/kg body weight for 30 days to diabetic rats resulted in significant reduction in blood glucose, reduction in lipid profile a...

  17. Comparison of anti-inflammatory activity of nigella sativa and diclofenac sodium in albino rats

    International Nuclear Information System (INIS)

    Background: Nigella sativa or Kalonji is a naturally occurring plant in Pakistan and other countries which possesses a wide range of medicinal properties, the anti-inflammatory property being one of these. Diclofenac sodium is a commonly used anti-inflammatory drug. The purpose of this study was to compare the anti-inflammatory effect of ethanolic extract of Nigella sativa seeds with that of diclofenac sodium in albino rats. Method: This laboratory randomized controlled trial (RCT) was conducted in the Physiology Department, Services Institute of Medical Sciences (SIMS), Lahore. The study was carried out on 90 male albino rats. Five percent formalin in a dose of 50 meu was injected into sub-plantar surface of right hind paw of each rat to produce inflammation. The rats were randomly divided into three groups of thirty each. Group A was given normal saline (control); group B was given Nigella sativa seed extract; and group C received diclofenac sodium, as a reference drug. Increase in paw diameter, and total and differential leukocyte counts were measured as markers of inflammation. Results: Nigella sativa seeds extract caused significant (p<0.05) reduction in the paw inflammatory response in albino rats. The effect was longer in duration than the effect caused by diclofenac sodium; however, the extract was comparatively less potent than diclofenac sodium. The extract had no significant effect (p>0.05) on the total or differential leukocyte counts. Conclusion: Our results suggest that ethanolic extract of Nigella sativa seeds possesses potent anti-inflammatory effect, in albino rats however, this effect is comparatively less but prolonged than that produced by diclofenac sodium. (author)

  18. Assessment of anti-nociceptive efficacy of Costus Speciosus rhizome in swiss albino mice

    OpenAIRE

    Upendra Nagaich; Sanjib Bhattacharya

    2010-01-01

    Present study attempts to evaluate the anti-nociceptive activity of the aqueous and ethanol extracts of Costus speciosus rhizome (CPA and CPE) in Swiss albino mice. The maceration extracts were evaluated for anti-nociceptive activity by acetic acid-induced writhing and tail flick method in mice. The anti-nociceptive screening revealed significant peripheral anti-nociceptive actions of both extracts against acetic acid induced writhing in mice. Aqueous extract (CPA) significantly inhibited wri...

  19. Physiological Changes Induced by Long Term Administration of Saccharin Compared with Aspartame to Male Albino Rats

    OpenAIRE

    Abdallah, Inas Z. A.

    2002-01-01

    Artificial sweeteners have been in use by food industries for a long time. Safety concerns raised about artificial sweeteners since they are widely used nowadays. The present work aims to study the possible changes in body weight, blood picture, liver functions, blood glucose and liver glycogen content as wel as histopathological changes induced in liver and urinary bladder of male albino rats after administration of two artificial sweeteners (saccharin or aspartame). Male rats were administe...

  20. Eficacia comparativa de un probiótico vs un antibiótico en la respuesta clínica de pacientes con sobrecrecimiento bacteriano del intestino y distensión abdominal crónica funcional: un estudio piloto

    OpenAIRE

    Luis Oscar Soifer; Daniel Peralta; Guillermo Dima; Horacio Besasso

    2010-01-01

    Introducción. Habitualmente los pacientes con sobrecrecimiento bacteriano del intestino son tratados con el empleo de diversos antibióticos. Actualmente existen evidencias de que determinados probióticos presentan efectividad en la respuesta clínica en pacientes con distensión abdominal con o sin intestino irritable. Objetivos. Establecer la eficacia clínica comparativa a corto plazo del metronidazol vs un probiótico en pacientes con sobrecrecimiento bacteriano del intestino y distensión abd...

  1. Citrus aurantifolia impairs fertility facilitators and indices in male albino wistar rats

    Directory of Open Access Journals (Sweden)

    Uduak Akpan Okon

    2014-06-01

    Full Text Available Background: The ability to reproduce is one of lifes essential functions; therefore factors that affect this ability are of vital importance to mankind. We therefore designed this study to assess the effect of various dosages of C. aurantifolia treatment on fertility promoters and indices in male albino wistar rats. Methods: Toxicity studies showed no lethality at 5000 mg/kg. Eighteen male albino wistar rats weighing between 220 and 240 g were used. They were randomly assigned into three groups of six rats each. Group one served as control and was gavaged 5 ml of normal saline, groups two and three were gavaged 1000 mg/kg and 1500 mg/kg body weight as medium and high dose respectively twice daily for 21 days. On the 22nd day, the rats were sacrificed and blood samples were obtained by cardiac puncture; following standard procedure, the serum was obtained for hormonal (FSH, LH, prolactin and testosterone assay using microplate immunoenzymometric assay. The testes were harvested for semen analysis. Results: LH level was significantly lower in medium dose (P Citrus aurantifolia possess antifertility potentials in male albino wistar rats. Excessive intake should be with caution in males with fertility challenges. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 640-645

  2. Evaluation of hepatoprotective activity of aqueous extracts of leaves of Basella alba in albino rats.

    Science.gov (United States)

    Das, Saibal; Bandyopadhyay, Sanjib; Ramasamy, Anand; Mondal, Somnath

    2015-01-01

    This study was done to evaluate possible hepatoprotective effects of aqueous leaf extracts of Basella alba in comparison with silymarin in paracetamol-induced hepatotoxicity in albino rats. Six groups of six albino rats each received orally for 6 weeks, vehicle, paracetamol (2 g/kg/day), paracetamol (2 g/kg/day) plus silymarin (50 mg/kg/day), paracetamol (2 g/kg/day) plus B. alba extract (60 mg/kg/day), paracetamol (2 g/kg/day) plus B. alba extract (80 mg/kg/day) and paracetamol (2 g/kg/day) plus B. alba extract (100 mg/kg/day). Hepatoprotective effect was evaluated by comparing serum bilirubin, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, proteins, alkaline phosphatase and liver histopathology. Results were represented as mean ± SEM. One-way ANOVA was done followed by post hoc Tukey's test with a highly significance level of P alba 100 mg/kg/day orally had significant hepatoprotective effect in paracetamol-induced hepatotoxicity in albino rats. The results were well comparable and even in some respects superior to standard drug silymarin. PMID:25347929

  3. Histological review of skin cancers in African Albinos: a 10-year retrospective review

    International Nuclear Information System (INIS)

    Skin cancer is rare among Africans and albinism is an established risk for skin cancer in this population. Ultraviolet radiation is highest at the equator and African albinos living close to the equator have the highest risk of developing skin cancers. This was a retrospective study that involved histological review of all specimens with skin cancers from African albinos submitted to The Regional Dermatology Training Center in Moshi, Tanzania from 2002 to 2011. A total of 134 biopsies from 86 patients with a male to female ratio of 1:1 were reviewed. Head and neck was the commonest (n = 75, 56.0%) site affected by skin cancers. Squamous cell carcinoma (SCC) was more common than basal cell carcinoma (BCC) with a ratio of 1.2:1. Only one Acral lentiginous melanoma was reported. Majority (55.6%) of SCC were well differentiated while nodular BCC (75%) was the most common type of BCC. Squamous cell carcinoma is more common than basal cell carcinoma in African albinos

  4. Radiomodulatory effect of Grewia asiatica fruit extract in Swiss albino mice

    International Nuclear Information System (INIS)

    Full text: The present study evaluates the effect of Grewia asiatica fruit pulp extract (GAE) on Swiss albino mice against radiation induced hematological and biochemical alterations. Swiss albino mice (6-8 weeks) were divided into four groups. Group I (Normal) without any treatment. Group II (Only drug) was orally supplemented (GAE) once daily at the dose of 700 mg/kg. b.wt/day for 15 days. Group III (Control) exposed whole body to 5 Gy gamma radiations. Group IV (Experimental) was first exposed to 5 Gy gamma radiations than administered GAE for 15 days as in group II. Mice were sacrificed at various post treatment intervals viz. 1-30 days. Radiation induced deficit in different blood constituents and biochemical parameters viz. GSH, sugar and protein levels could be significantly augmented, whereas radiation induced elevation of lipid peroxidation and cholesterol level was markedly decreased in GAE post-treated animals. Results indicate that GAE provides protection against radiation-induced alterations in blood of Swiss albino mice

  5. Tratamiento de las fracturas del húmero proximal con placas bloqueadas

    OpenAIRE

    Arenas Planelles, Antonio; D'Arrigo, A.; Arenas Miquélez, A.; Jiménez Sarmiento, O.

    2011-01-01

    Se presentan 86 casos de fractura compleja de húmero proximal tratados mediante reducción abierta y osteosíntesis con placa bloqueada. Los resultados fueron buenos en la mayor parte de los pacientes. Los autores analizan los factores que han influido en los resultados del tratamiento 86 cases of complex fracture of the proximal humerus are presented. They were treated by open reduction and internal fixation with a locking plate. The results were satisfactory at most of the patient...

  6. Control de pacientes con problemas isquémicos en miembros inferiores

    OpenAIRE

    Armero Barranco, David; Alcaraz Baños, Miguel; Bernal Páez, F.L.; Felices Abad, J.M.

    2002-01-01

    La isquemia de miembros inferiores, es una patología frecuente entre los pacientes que acuden a una unidad de Radiología Vascular para ser diagnosticados y/o tratados. La exploración mediante doppler lineal (realizada en nuestro centro por el personal de enfermería) para problemas circulatorios en miembros inferiores, junto con la angiografía también de miembros inferiores, son las exploraciones que mas frecuentemente realizamos en estos pacientes. Objetivo: Se pretende determinar un posi...

  7. GCompris: un software multinivelar con clara aplicación para las matemáticas

    OpenAIRE

    Real, Mariano

    2011-01-01

    En esta sección MatemásTIC de la revista Suma hemos estado analizando y haciendo un recorrido por aplicaciones de software libre o bien con licencia GPL de forma que el uso de estas aplicaciones no tenga un coste económico y se puedan disponer de las mismas en la red o bien a través de los repositorios de las diferentes distribuciones Linux. En ese recorrido que aún seguimos, hemos tratado aplicaciones recomendadas para el aula de matemáticas haciendo especial hincapié en aplicaciones indicad...

  8. Actividades enriquecidas con el uso de vídeos en aulas hospitalarias

    OpenAIRE

    Serrano Sánchez, José Luis; López Moya, Mª Del Pilar

    2014-01-01

    En los últimos años han proliferado buenas prácticas en el uso de Tecnologías de la Información y la Comunicación en contextos educativos hospitalarias, y en ocasiones se han llevado a cabo investigaciones que han tratado de analizar las posibilidades de las tecnologías en estos espacios educativos. Partiendo de estas experiencias, presentamos una innovación educativa con el uso del vídeo como tecnología enriquecedora de los procesos educativos en las aulas hospitalarias de ...

  9. Los servicios profesionales en América del Norte. Un análisis de sus resultados y perspectivas a partir del Tratado de Libre Comercio

    Directory of Open Access Journals (Sweden)

    María Yira Figueroa Olvera

    2008-01-01

    Full Text Available Este trabajo presenta las características actuales del mercado laboral en América del Norte, para ello se toma como marco de referencia el Tratado de Libre Comercio de América del Norte (TLCAN. Asimismo, se analizan los resultados actuales y las perspectivas futuras de la prestación de servicios profesionales entre Canadá, Estados Unidos y México; los servicios profesionales más demandados; los requisitos para su prestación; así como las oportunidades de acceso y restricciones para los profesionistas mexicanos interesados en incorporarse. El argumento central es que uno de los sectores más dinámicos en la generación de empleo es el de servicios, y que éste a su vez presenta prioridades y particularidades entre los tres países. Por otra parte, no podemos soslayar que hay un aumento de la migración de mexicanos altamente calificados en relación con años anteriores. No obstante, una mayor movilidad de profesionistas en el mercado laboral de América del Norte sigue siendo un reto para México, pese a las negociaciones existentes, y más bien se ha caracterizado por cubrir las necesidades estratégicas de la economía de la región, donde también repercute la política migratoria de cada país. Finalmente, a manera de reflexión, se presentan los resultados indirectos de la migración de profesionales, como la fuga de cerebros.

  10. Solubilidade de metais pesados em solos tratados com lodo de esgoto enriquecido

    Directory of Open Access Journals (Sweden)

    C. Oliveira

    2003-02-01

    Full Text Available Os lodos de esgoto são materiais orgânicos ricos em nutrientes com potencial para o uso agrícola. A utilização desses materiais, no entanto, pode ser limitada pela presença de metais pesados na sua composição. Esta pesquisa teve por objetivos: (a avaliar a solubilidade de Cd, Pb e Zn em dois tipos de solos tratados com lodo de esgoto enriquecido com esses metais; (b verificar o efeito do tempo de contato nas mudanças da distribuição de Cd, Pb e Zn nas diferentes formas químicas de dois solos tratados com lodo de esgoto enriquecido com esses metais; (c verificar a influência das frações inorgânicas e orgânicas do lodo na dinâmica destes metais no solo. O enriquecimento do lodo de esgoto consistiu em adicionar Cd, Pb e Zn a um lodo de esgoto urbano produzido na Estação de Tratamento da Ilha do Governador (ETIG, Rio de Janeiro (RJ. Após 20 dias de incubação, sob umidade constante (50 % g g-1, o lodo enriquecido foi utilizado para a instalação de experimentos em amostras de duas classes de solos: Latossolo Vermelho-Amarelo (LV e Argissolo Vermelho-Amarelo (PV. Em laboratório, as amostras dos solos foram incubadas com quantidades equivalentes a 0; 20; 40 e 80 t ha-1 de lodo de esgoto enriquecido. Nos tempos de contato solo-lodo enriquecido de 4, 12, 16, 24 e 160 semanas, amostras de solos foram retiradas e submetidas à extração seqüencial de Cd, Pb e Zn. Observou-se, através da extração seqüencial, que compostos orgânicos solúveis formaram complexos, principalmente com cádmio e zinco, mantendo teores elevados destes elementos associados à fração solúvel em água durante todo o período experimental. A incorporação de compostos inorgânicos de Fe e Mn, através do lodo de esgoto, permitiu que o Cd, Pb e Zn se ligassem em sua maior parte, à fração extraível com hidroxilamina. Com o tempo de incubação, observou-se decréscimo dessa fração com aumento da fração residual, indicando decréscimo na

  11. Productividad y tratados de libre comercio a nivel de empresas en Perú

    OpenAIRE

    Nikita Céspedes; Maria E. Aquije; Alan Sánchez; Rafael Vera-Tudela

    2014-01-01

    En este documento se estudia la relación de la productividad con la apertura comercial en el Perú haciendo uso de un modelo pseudo experimental. Se considera dos indicadores de productividad medidos a nivel de firmas formales: la productividad laboral y la productividad total de factores. Se encuentra que las firmas que participan del comercio internacional ya sea como exportadores y/o importadores tienen sistemáticamente una mayor productividad en comparación con las que destinan su producci...

  12. El reto de la contribución de la organización del Tratado de Cooperación Amazónica – OTCA– para el bienestar de las poblaciones locales y fronterizas

    Directory of Open Access Journals (Sweden)

    Fernando Franco Hernández

    2014-05-01

    Full Text Available El documento aborda la descripción de las dinámicas sociales, económicas y políticas de las poblaciones fronterizas asentadas en la Amazonia, que discurren en medio de situaciones de conflicto y con formas diferenciadas de presencia de los Estados nacionales y sus instituciones. El escrito expone las políticas de organismos multilaterales como la OTCA (Organización del Tratado de Cooperación Amazónica, que tienen como objetivo formular planes y agendas estratégicas en torno al desarrollo sostenible y al uso y conservación de los sistemas naturales amazónicos y sus recursos. El argumento central es que tales políticas, planes y programas tienen un impacto mínimo en la resolución de los problemas y conflictos que enfrentan los pueblos amazónicos, dada la ausencia de instrumentos que articulen las formulaciones de carácter general con propuestas y proyectos que conduzcan al desarrollo sostenible y a un mejor vivir de las poblaciones amazónicas a escala regional.

  13. Protocolo quirúrgico en la reconstrucción de la parálisis facial: nuestra experiencia tras 140 casos tratados Protocol in surgical treatment of facial paralysis after 140 treated cases

    Directory of Open Access Journals (Sweden)

    B. Hontanilla Calatayud

    2008-09-01

    Full Text Available El objetivo de este trabajo es presentar nuestro protocolo de actuación en el tratamiento quirúrgico de la parálisis facial tras 140 casos tratados entre los años 2000 y 2007. Este protocolo está basado en los resultados obtenidos con un nuevo sistema de captura del movimiento facial en 3D denominado "Facial Clima", que puede ser considerado como un método objetivo de medición de los resultados en la cirugía de reanimación facial. Así podría compararse en pacientes con parálisis facial, la efectividad de los tratamientos entre distintos centros. Exponemos los resultados obtenidos tanto a nivel de la reconstrucción de la sonrisa como a nivel palpebral.The aim of this study is to present our protocol in the surgical treatment of facial paralysis after 140 treated cases since 2000 to 2007. The protocol is based on the results obtained with a new 3-D capture system of the facial movement called "Facial Clima", that could be considered as the adequate tool to assess the outcome of the facial paralysis reanimation surgery. Thus, patients with facial paralysis could be compared among surgical centres such that effectiveness of facial reanimation operations could be evaluated. The results obtained are exposed for smile and lid reconstruction.

  14. La construcción de la bóveda de arista rectangular en el tratado de Gelabert: teoría y práctica

    Directory of Open Access Journals (Sweden)

    Senent-Domínguez, R.

    2013-10-01

    Full Text Available The groin vault is one of the most common types of vaults in Spain, designed to cover square spaces. When the groin vault is arranged on a rectangular plan, the vaulting system must be adapted to the new situation. This new arrangement multiplies the problems, entailing in different constructive solutions. This paper analyzes the theoretical model of the rectangular groin vault as proposed in stonecutting treatises (16th-18th centuries, focusing on the manuscript by Joseph Gelabert (17th century, and its relationship with vaults built in Palma de Mallorca from the 16th to the 18th century. Special attention is paid to the carving of the pieces of the groins by means of templates and their relationship to the “problem of the solid angle”, providing new data on a drawing in the manuscript of Hernán Ruiz the Younger (16th century.Entre los tipos de bóvedas más habituales del renacimiento español está la bóveda de arista, concebida para cubrir recintos cuadrados. Cuando la bóveda de arista se dispone sobre una planta rectangular, es necesario que el sistema de abovedamiento se adapte a esta nueva situación, lo que multiplica los problemas, dando lugar a diversas soluciones constructivas. Este artículo analiza el modelo teórico de bóveda de arista rectangular propuesto por los tratados de cantería de los siglos XVI-XVIII, centrándose en el manuscrito del mallorquín Joseph Gelabert (s. XVII, y su relación con bóvedas de este tipo construidas en la ciudad de Palma de Mallorca entre los siglos XVIXVIII. Se presta especial atención al problema de la labra de las dovelas de la arista por medio de plantillas y su relación con el “problema del ángulo sólido”, aportando nuevos datos sobre un dibujo del manuscrito de Hernán Ruiz el Joven (s. XVI.

  15. White versus blue: Does the wild 'albino' bilberry (Vaccinium myrtillus L.) differ in fruit quality compared to the blue one?

    Science.gov (United States)

    Zorenc, Zala; Veberic, Robert; Stampar, Franci; Koron, Darinka; Mikulic-Petkovsek, Maja

    2016-11-15

    Wild albino and blue bilberry fruit were analyzed to compare different fruit characteristics linked to the composition of primary and secondary metabolites. Compounds were identified using HPLC-MS and standard quality parameters were determined. Albino berries were significantly smaller, accumulated less water and were characterized by 23% higher dry weight. Soluble solids content and pH value were higher in albino bilberry and their surface was lighter and characterized by a yellow hue. Both bilberry forms accumulated identical individual sugars and organic acids; however, the albino form had 33% higher content of total sugars and 9% higher content of total organic acids compared to the blue type. Fifteen anthocyanins were identified in both forms, but in albino bilberries, individual anthocyanins were only detected in traces. Blue bilberry contained 1.6-fold higher levels of flavanols, 2.1-fold higher levels of flavonols, 2.5-fold higher levels of hydroxycinnamic acid derivatives and consequently, 4.6-fold higher total phenolic content. PMID:27283708

  16. Mineralização de nitrogênio em solo tropical tratado com lodos de esgoto

    Directory of Open Access Journals (Sweden)

    Boeira Rita Carla

    2002-01-01

    Full Text Available A mineralização do N orgânico é um dos principais fatores que determinam as quantidades de lodos de esgoto (LE a aplicar em solos. O objetivo deste trabalho foi quantificar, em laboratório, o potencial de mineralização de N orgânico num Latossolo Vermelho distroférrico, tratado com dois LE anaeróbios, um de origem estritamente urbana (Franca, SP e outro com presença de despejos industriais (Barueri, SP. Os LE foram aplicados ao solo em doses de 1,5, 3, 6 e 12 g kg-1 (Franca e 4, 8, 16 e 32 g kg-1 (Barueri, e o tempo de incubação foi de 15 semanas. O acúmulo de N inorgânico no solo ao final da incubação foi proporcional às quantidades de N orgânico adicionadas. O potencial de mineralização estimado pelo modelo exponencial simples foi de 24 mg kg-1 de N no solo sem lodo, e variou entre 44 e 265 mg kg-1 de N no solo tratado com os lodos. A fração de mineralização potencial do N orgânico dos lodos foi estimada em 31%. A mineralização foi mais lenta no solo tratado com as duas maiores doses do LE de Barueri. Os dois lodos acidificaram o solo; o de Franca causou acidificação mais intensa que o de Barueri.

  17. Lixiviação de metais pesados em solos tratados com lodo de esgoto

    Directory of Open Access Journals (Sweden)

    E. I. Bertoncini

    1999-09-01

    Full Text Available Foi realizado um experimento em tubos de percolação, utilizando-se três solos, classificados como Areia Quartzosa (AQ, Latossolo Vermelho-Amarelo (LV e Latossolo Vermelho-Escuro (LE, aos quais foram incorporadas sucessivas quantidades de lodo de esgoto, totalizando uma dose correspondente a 156,0 t ha-1 (base seca, num período de incubação de 310 dias. Após este período, os solos foram tratados com água ou com soluções de sais (KCl 0,9 mol L-1; KNO3 0,9 mol L-1; K2SO4 0,3 mol L-1 e Ca(NO32 0,3 mol L-1, adicionadas em quantidade correspondente a quatro vezes a capacidade de retenção de água dos solos. No líquido percolado pela passagem das soluções salinas, foram determinadas as quantidades de Cd, Cr, Cu, Ni e Zn presentes e, no percolado obtido com a passagem de água, além dos metais anteriormente citados, foram determinadas também as quantidades de Ca2+ e Mg2+. Os resultados permitiram observar que a adição de KCl provocou o arraste de 5% do Cd adicionado via lodo aos solos LV e LE; para os outros sais utilizados e para a água, esse arraste nunca foi superior a 2% do metal pesado adicionado via lodo. A retenção de Cd, Cu, Cr e Ni aumentou com a elevação dos teores de óxidos de Fe e Al presentes nos solos. Os elevados valores de pH e o aumento no teor de matéria orgânica proporcionado pela adição de lodo refletiram também na menor mobilidade dos metais. Os sais KCl e K2SO4 aumentaram a mobilidade de alguns dos metais estudados.

  18. LOS TRATADOS INTERNACIONALES EN LA CONSTITUCIÓN DE 1980.: JURISPRUDENCIA EN LA DÉCADA DE 1981-1989

    Directory of Open Access Journals (Sweden)

    Guillermo Bruna Contreras

    2003-01-01

    Full Text Available El presente artículo realiza un análisis de la doctrina y la jurisprudencia chilena respecto de la ubicación de los tratados internacionales en general dentro de la fuentes del derecho constitucional chileno, bajo el imperio de la Constitución de 1980, entre 1981 y 1989.Scholarship and the doctrine emanating from judicial decisions are considered here, with respect to the status of international treaties as sources of Chilean Constitutional Law under the provisions of the Constitution of 1980, between the years of 1981 and 1989.

  19. Organizaciones internacionales y tratados asociativos: por una nueva clasificación de los sujetos de derecho internacional

    OpenAIRE

    Raphael Carvalho de Vasconcelos

    2015-01-01

    La personalidad jurídica es elemento fundamental para la actuación de un sujeto en el orden internacional. La efectiva participación en el espacio global no depende, sin embargo, sólo del cumplimiento de este requisito. Doctrina y jurisprudencia reconocen la personificación de las organizaciones internacionales actualmente sin grandes reservas, pero, ¿correspondería entender que cualquier tratado dotado de personería jurídica debe ser considerado investido de poderes para actuar en el orden i...

  20. Intoxicação aguda por triclorfon em caprinos tratados com a dose terapêutica

    OpenAIRE

    2014-01-01

    O presente estudo descreve um surto de intoxicação por triclorfon em caprinos, que receberam pela via oral, a dosagem terapêutica do princípio ativo em questão (100mg/kg), provenientes da Universidade Estadual de Maringá, campus de Umuarama, PR. Cinquenta e três ovinos foram tratados com a mesma formulação/solução e não se observou nenhum efeito colateral nos animais referente ao tratamento com triclorfon. Das 20 cabras medicadas, cerca de 40 minutos após a administração do triclorfon, oito a...

  1. Qualidade de caquis Fuyu tratados com cálcio em pré-colheita e armazenados sob atmosfera modificada

    OpenAIRE

    FERRI VALDECIR CARLOS; RINALDI MARIA MADALENA; LUCHETTA LUCIANO; ROMBALDI CESAR VALMOR

    2002-01-01

    Avaliou-se a eficiência do cálcio (CaCl2) na conservação de caquis Fuyu armazenados em temperatura ambiente (TA), atmosfera refrigerada (AR) e modificada (AM). Utilizou-se um delineamento inteiramente casualizado, com quatro repetições. Os caquizeiros foram tratados com 1% de CaCl2, em pulverizações de cobertura total, a cada 15 dias, a partir de 90 dias antes da data prevista para a colheita. Para a testemunha, pulverizaram-se as plantas com água destilada. As frutas foram colhidas com 65-75...

  2. Cuidados con el anciano con tos productiva.

    OpenAIRE

    Costa de Moura, María Lucia

    2005-01-01

    A partir de las informaciones y con la motivación para hacer un estudio dirigido a los cuidados con el anciano, sigue la necesidad del desarrollo de acciones pertinentes para la práctica de cuidar, o sea, la asistencia de enfermería prestada directamente al anciano, principalmente a aquellos que llegan a la unidad de salud quejándose de tos. El objeto de este estudio es la asistencia de enfermería basándome en las cuestiones que rodean la percepción del enfermero y cómo el...

  3. Cifrado con cubos marcados

    OpenAIRE

    Coriat, Moisés; María C. Cañadas

    2011-01-01

    Con cuatro de los 8 tetracubos y con la ayuda de la noción de cubo mínimo (cubo formado por dos tetracubos), introducimos los “cubo marcados”. A su vez, usamos esta idea para generar claves con las que cabe transmitir mensajes cifrados. Damos ejemplos de claves y mencionamos algunas posibilidades más de cifrado con dichos cubos marcados. En la introducción presentamos algunas facetas del cifrado. Después, describimos algunos policubos y prestamos especial atención a los cuatro tetracubo...

  4. TRACE ELEMENT AND LIGHT MICROSCOPIC STUDIES ON TESTIS OF ALBINO RATS TREATED WITH SILDENAFIL CITRATE (CAVERTA

    Directory of Open Access Journals (Sweden)

    K.V.P. Suriyakumari

    2015-06-01

    Full Text Available Background: Caverta (Sildenafil citrate, an oral therapy for Erectile Dysfunction (ED, being the citrate salt of Sildenafil, is a selective inhibitor of cGMP- specific phosphodiestrase type (PDE5. Aim: To study the drug- induced (i changes in the trace element content of Testis and (ii changes in the histoarchitecture of Testis of the experimental Albino rats. Materials and Methods: For the present study, totally 48 animals were selected on weight basis and divided into 8 groups (S1, S2, S3, S4, S5, S6, S7 and S8 with six animals in each group. Control animals (S1 were fed with conductivity water while the experimental animals (S2, S3, S4 and S5 were treated with a single dose of Caverta (@ 1µg/g body weight. Control animals were sacrificed at zero hour while the experimental animals (S2, S3, S4 and S5 were sacrificed after 1 hour, 2½ hours, 4 hours and 24 hours of drug administration respectively S6, S7 and S8 group of animals were fed with a single dose of the chosen drug (@ 1µg/g body weight daily for all the 15, 30 and 45 days respectively. These animals were sacrificed after 4 hours of the last dosage. Vertical ventral midline incision was made in the abdominal wall to collect the left and right Testes. Results: The spectral analysis indicates that the long term Caverta treatment of Albino rats results in the accumulation of Iron and Copper levels accompanied by a depletion of Nickel levels in the Testis. The histological studies indicate that long term exposure of Testis to Caverta leads to distorted histoarchitecture of the seminiferous tubules, interstitial space dilation and separation of Spermatogenic cells. Conclusion: Long term Sildenafil Citrate (Caverta treatment of Albino rats will bring in adverse effects and will completely alter the histoarchitecture of the Testis.

  5. EVALUATION OF ANTINOCICEPITVE ACTION OF PENTAZOCINE IN COMPARISION WITH MORPHINE IN ALBINO RATS

    Directory of Open Access Journals (Sweden)

    Manikanta

    2014-12-01

    Full Text Available : OBJECTIVES: To evaluate the antinociceptive effect of pentazocine in three graded doses (3, 6 and 12 mg/kg and its combination with morphine at sub-analgesic doses, and comparing their effect with analgesic dose of morphine (1mg/kg by tail flick method in albino rats. MATERIALS & METHODS: Tail flick method using analgesiometer and tail immersion test by hot water bath was selected for evaluating antinociceptive action of pentazocine and standard drug morphine. RESULTS: Pentazocine in the doses of 6mg/kg, 12 mg/kg intra peritoneal (i.p and morphine 1mg/kg i.p, produced significant antinociceptive effect in comparison to control by tail flick test and tail immersion test. Pentazocine 3 mg/kg, i.p and morphine 0.1 mg/kg, i.p had not produced significant antinociceptive action when given alone, but combination (pentazocine 3 mg/kg + morphine 0.1 mg/kg treatment produced significant antinociceptive effect in comparison to control. CONCLUSION: Pentazocine in the doses of 6 mg/kg, 12 mg/kg and their combination in low doses (pentazocine 3 mg/kg + morphine 0.1 mg/kg demonstrated significant antinociceptive activity in albino rats. Combination in low doses (pentazocine 3 mg/kg + morphine 0.1 mg/kg showed comparable antinociceptive activity with pentazocine 6 mg/kg in albino rats. STATISTICAL ANALYSIS: One way ANOVA and multiple comparison test (LSD was applied only to MPE% at 60 min.

  6. Effect of ultraviolet B irradiation on epidermis of albino mice: morphological study

    International Nuclear Information System (INIS)

    An optical and electron microscopical study were done on irradiated, shaved albino mice in order to verify the elastic fiber system and collagen changes occurring after irradiator disruption (0, 30, 60 and 90 days). Our comparative study of groups disclosed the clear relationship between dose and elasto tic changes and also that chronological aging of mice dermis apparently was intensified after UV B irradiation. Furthermore, fibroblasts present in the study seems to be cell responsible for these matrix modifications. (author). 42 fig, 214 refs

  7. Evaluation of antidiabetic, antioxidant effect and safety profile of gomutra ark in Wistar albino rats

    OpenAIRE

    Sachdev, Devender O.; Gosavi, Devesh D.; Kartik J Salwe

    2012-01-01

    The effect of Gomutra ark (GoA) on experimental alloxan-induced diabetes in rats was studied. For this purpose, Wistar albino rats of either sex weighing 200-250 g were used. The biochemical parameters like blood sugar, vitamin C, and malondialdehyde release were measured. The safety profile of GoA was evaluated using acute and chronic toxicity studies. GoA significantly lowers blood glucose in diabetic rats although the observed effect was found to be less than glibenclamide. It significantl...

  8. Experimental adiaspiromycosis in animals with a modified reactivity (Albino mice) after irradiation

    International Nuclear Information System (INIS)

    The nature of the pathologic process in experimental adiaspiromycosis, following intraperitoneal inoculation with elements of the mycelium phase of Emmonsia crescens Emmons et Jellison (1960), depends on the reactivity of the experimental animals. Compared with a control group of animals, inoculated albino mice (with a single dose of 250 rad) contracted adiaspiromycosis more readily, there was a higher incidence of positive findings, aleirospore dissemination to distant organs outside the abdominal cavity occurred earlier, the intensity of tissue and organ insemination of the host was much higher. The results of these studies show that individuals with low resistance and increased susceptibility to infection are particularly liable to contract adiaspiromycosis. (author)

  9. Hepatotoxicity and nephrotoxicity evaluation in Wistar albino rats exposed to Morinda lucida leaf extract

    OpenAIRE

    Taofeeq Oduola; Ibrahim Bello; Ganiyu Adeosun; Abdul-Waheed Ademosun; Gassal Raheem; Godwin Avwioro

    2010-01-01

    Background: Aqueous extract of Morinda lucida benth leaf is consumed in Southern Nigeria in the treatment of malaria without any regard for its safety. Aim: The aim of the study was to investigate the effects of ingestion of the ethanolic leaf extract of the plant on liver and kidney functions in Wistar albino rats. Materials and Methods: Acute oral toxicity test was performed to determine the LD 50 ; sub-chronic toxicity study was then carried out by oral administration of different doses of...

  10. Effect of cassava based diet on some heamatological parameters in albino rats fed petroleum contaminated diet

    Directory of Open Access Journals (Sweden)

    A O Adegoke

    2012-04-01

    Full Text Available The study was carried out to ascertain the effect of a cassava based diet (gari on crude oil heamato-toxicity in albino rats by feeding diet contaminated with various concentrations of crude oil mixed with 20% gari to determine the protective effect of gari. The haematological parameters haemoglobin (Hb, Packed cell volume (PCV and white blood cell count (WBC(Total and differential were monitored in the animals. Gari feeding at 20% caused insignificant dose dependent decrease in Hb and PCV but significant dose dependent white blood cell count in gari fed albino rats compared with Petroleum fed albino rats (P<0.05. Dose dependent decrease in Hb, PCV and white blood cell count was also observed in petroleum fed rats compared with their controls (P<0.05.  The study showed that ingestion of petroleum contaminated diet caused decreased haemoglobin (Hb, Packed cell volume (PCV and white blood cell count, an indicator of possible blood damage but supplementation of the diet with 20% gari decreased the haemoglobin (Hb, Packed cell volume (PCV and white blood cell count observed in petroleum fed albino rats. This study showed that feeding on gari diet did not reverse the damage caused by crude petroleum as evidenced by insignificant differences in Hb and PCV concentrations possibly as result of cyanide present in the gari.Industrial relevanceCassava is a staple food in human diets in over 80 countries (Gomez, et al 1988. Gari a starchy food prepared from cassava (Manihot utilisima tubers is one of the most popular staple foods of the people of the rain forest belt of West Africa. Gari contains mainly starch-20% amylase and 70% amylopectin having lost the soluble carbohydrates. Crude petroleum is capable of eliciting haemolytic toxicity of the blood cells in conditions of long- exposure causing decrease haemoglobin, white cell count and PCV levels. The study was carried out to see the effect of gari, a staple food on haemolytic toxicity caused by crude

  11.  Miners’ magic: artisanal mining, the albino fetish and murder in Tanzania

    DEFF Research Database (Denmark)

    Bryceson, Deborah; Jønsson, Jesper Bosse; Sherrington, Richard

    2010-01-01

    local profit maximisation. The murders are connected to gold and diamond miners’ efforts to secure lucky charms for finding minerals and protection against danger while mining. Through the concept of fetish creation, this article interrogates the agency of those involved in the murders : the miners who......A series of murders of albinos in Tanzania’s north-west mining frontier has been shrouded in a discourse of primitivism by the international and national press, sidestepping the significance of the contextual circumstances of an artisanal mining boom firmly embedded in a global commodity chain and...

  12. Camellia sinensis (L.) Kuntze Extract Ameliorates Chronic Ethanol-Induced Hepatotoxicity in Albino Rats

    OpenAIRE

    Poonam Lodhi; Neeraj Tandan; Neera Singh; Divyansh Kumar; Monu Kumar

    2014-01-01

    The goal of this study was to investigate the hepatoprotective effects of aqueous extract of Camellia sinensis or green tea extract (AQGTE) in chronic ethanol-induced albino rats. All animals were divided into 4 groups in the study for a 5-week duration. 50% ethanol was given orally to the rats with two doses (5 mg/kg bw and 10 mg/kg bw) of AQGTE. Ethanol administration caused a significant increase in the levels of plasma and serum enzymatic markers, alanine aminotransferase (ALT), aspartate...

  13. Contraceptive effect of Curcuma longa (L.) in male albino rat

    Institute of Scientific and Technical Information of China (English)

    PurohitAshok; BhagatMeenakshi

    2004-01-01

    Aim:To study the contraceptive effect of the crude extracts of Curcuma longa in male albino rats.Methods:Rats were fed orally with Curcuma longa aqueous and 70% alcoholic extract for 60 days (500 mg·kg-1·day-1).Results:A reduction in sperm motility and density was observed in both the treated groups.Conclusion:Curcuma longa may have affected the androgen synthesis either by inhibiting the Leydig cell function or the hypothalamus pituitary axis and as a result,spermatogenesis is arrested.(Asian J Androl 2004 Mar;6:71-74)

  14. In vivo Anticancer Activities of Benzophenone Semicarbazone against Ehrlich Ascites Carcinoma Cells in Swiss Albino Mice

    International Nuclear Information System (INIS)

    Benzophenone semicarbazone (BSC) was synthesized and characterized to identify compounds with anticancer activities. Anticancer activities were studied against Ehrlich Ascites Carcinoma (EAC) cells in Swiss albino mice by monitoring parameters such as tumor weight measurement, survival time of tumor bearing mice, tumor cell growth inhibition, and so on. Some hematological parameters, such as red blood cells, white blood cells, and hemoglobin content, were also measured. The results showed that BSC has a positive effect against EAC cells. An assessment was conducted by comparing these results with those obtained using the standard drug bleomycin. The BSC compound can be considered as a potent anticancer agent

  15. Sub-Acute Toxicity Studies of Paracetamol Infusion in Albino Wistar Rats

    Directory of Open Access Journals (Sweden)

    Anurag Payasi

    2010-04-01

    Full Text Available The objective of the present study was to evaluate the sub-acute toxicity of paracetamol infusion in albino wistar rats (male and female at different dose levels, ranging from 16 to 66 mg/kg body weight. No mortality was seen in any of the treatment groups during the course of study. Various physiological, hematological as well as biochemical parameters were studied and found not to be changed significantly, indicating that paracetamol infusion is non toxic even at higher dose level in wistar rats. Overall safety and tolerability profile of paracetamol infusion is proved good and does not appear to carry risk of serious adverse effects.

  16. Antioxidant Effect of Caffeic Acid on Oxytetracycline Induced Lipid Peroxidation in Albino Rats

    OpenAIRE

    Jayanthi, R.; Subash, P.

    2010-01-01

    Caffeic acid is a well-known phenolic compound widely present in plant kingdom. The aim of this study was to investigate the possible protective effect of caffeic acid (CA) against oxytetracycline (OXT) induced hepatotoxicity in male Albino Wistar rats. A total of 30 rats weighing 150–170 g were randomly divided into five groups of six rats in each group. Oral administration of OXT (200 mg/kg body weight/day) for 15 days produced hepatic damage as manifested by a significant increase in serum...

  17. COMBINED EFFECT OF WATER CONTAMINATION WITH COBALT AND NICKEL ON METABOLISM OF ALBINO (WISTAR) RATS

    OpenAIRE

    Z. Kechrid, F. Dahdouh, R. M. Djabar, N. Bouzerna

    2006-01-01

    The contamination of water by metal compounds is a worldwide environmental problem. Concentration of metals is widely related to biochemical values, which are used in diseases diagnosis due to environmental toxicity. The sub-chronic combined effects of nickel and cobalt on body weight gain and biochemical parameters were determined and compared with those of Ni (2+) or Co (2+) alone in 6 weeks male albino (Wistar) rats. Animals were given drinking solutions of NiSO4 6H2O [Ni (II) cation, LD50...

  18. Effect of protein malnutrition on the metabolism of bone collagen in albino rats

    International Nuclear Information System (INIS)

    The effect of protein malnutrition on the metabolism of collagen in bone was studied in young female albino rats after a single injection of 3H-proline. Both specific and total radioactivities of hydroxyproline in the total collagen of the bone were found to decrease in the protein-deficient animals, indicating decreased rate of collagen synthesis. In the urine the amount of hydroxyproline excreted and total radioactivity of 3H-hydroxyproline were greatly decreased. The results of the present investigation therefore clearly indicate decreased synthesis and catabolism of collagen in bones of protein deficient animals compared to controls. (auth.)

  19. Haematologic changes in young adult Swiss albino mice after tritiated water administration

    International Nuclear Information System (INIS)

    Tritiated water (HTO) injected intraperitoneally to Swiss albino mice at the rate of 370 kBq (10 μCi)/g body weight has been found to cause certain alterations in blood parameters 1, 5, 7 and 15 days post injectionem. Leukocyte count dropped significantly post treatment. Differential leukocyte counting showed lymphocytes to be most affected which were reduced by 38.29% on 5th day p.i. Erythrocyte count, haemoglobin and haematocrit values though showed no significant changes at early intervals, these values were significantly lower at later intervals than those of control. (author)

  20. Response of peripheral blood to 131I treatment in Swiss albino mice

    International Nuclear Information System (INIS)

    Adult Swiss albino mice were treated with 333 kBq/g body weight (approximately 10.22 Gy/day) intraperitoneally and sacrificed at different post-treatment intervals. It was observed that erythrocyte counts, hemoglobin and hematocrit values decreased gradually, while the depletion in leukocyte count was abrupt at early intervals after treatment. The early decline in the leukocytes followed by more gradual may be due to the direct cell killing by the isotope. The indirect effect on the hematopoietic tissues may be responsible for the continued low levels of the different blood constituents during the later intervals. (author)

  1. Skin cancers in albinos in a teaching Hospital in eastern Nigeria - presentation and challenges of care

    OpenAIRE

    Opara Kingsley O; Jiburum Bernard C

    2010-01-01

    Abstract Background Albinism is a genetic disorder characterized by lack of skin pigmentation. It has a worldwide distribution but is commoner in areas close to the equator like Nigeria. Skin cancers are a major risk associated with albinism and are thought to be a major cause of death in African albinos. Challenges faced in the care of these patients need to be highlighted in order to develop a holistic management approach with a significant public health impact. The aim of the study was to ...

  2. EFFECT OF IMIDACLOPRID ON THE BIOCHEMICAL CONTENTS OF KIDNEYS IN MALE SWISS ALBINO MICE

    Directory of Open Access Journals (Sweden)

    M. NAGA PRASANNA

    2013-01-01

    Full Text Available Six groups (A, B, C, D, E and F of male Swiss albino mice (Mus musculus albinus were orally administered withvaried doses (0.4, 0.8, 1.6, 3.2, 4.0 and 8.0 mg/kg bw/mouse of imidacloprid; they showed significant decreasein protein, DNA and RNA content in the kidneys of all the treated groups of mice throughout the experimentalperiod (on day 1, 4, 8, 12, 16 and 30 of treatment when compared with controls. It is clear from the results thatthe insecticide caused marked disturbance in the metabolism of protein, DNA and RNA.

  3. Measurement of genome changes of greenable albino mutation line c.v. W25

    International Nuclear Information System (INIS)

    W25 was a greenable albino mutation line, which was derived from a temperature-sensitive genic male sterile rice 2177s, with 300 Gy gamma rays irradiation. During the whole growth duration, the leaves of W25 showed the following characters: white, greenism, albinism and greenism again. 70 primers were used for the detection of polymorphism, one of them gave polymorphic products. RAPD analysis of W25 and 2177s with random primer H05 indicated that there were two DNA bands differences

  4. Malignant transformation of actinic keratoses to squamous cell carcinoma in an albino

    Directory of Open Access Journals (Sweden)

    Ramalingam Vijaya

    2009-01-01

    Full Text Available A 25-year-old male, who was a known case of oculocutaneous albinism presented to us with right inguinal swellings of six months′ duration. He gave a preceding history of a similar lump in the right thigh, which was excised at the Chennai Government Hospital. He was diagnosed to have oculocutaneous albinism with actinic keratoses, with multiple squamous cell carcinomas (with metastatic deposits in the right inguinal region and cutaneous horns. The case is reported to highlight preventive aspects in the management of albinos.

  5. Reducción cerrada y osteosíntesis con agujas percutáneas en las fracturas del radio distal

    OpenAIRE

    Arenas Planelles, Antonio; Ortega Arruti, J.A.; Arenas Miquélez, A.; Ortega Sáez, M. (Marta)

    2009-01-01

    Se presentan 185 casos de fractura compleja del radio distal tratados con reducción ortopédica y estabilización con agujas de Kirschner introducidas de forma percutánea y asociadas a vendaje escayolado antebraquial. Los resultados funcionales finales fueron buenos o excelentes en 156 de los 185 casos (84,3%). Teniendo en cuenta los resultados, consideramos que el método es sencillo, útil y económico y debe valorarse su uso en la mayoría de las fracturas del radio distal. We report 185 case...

  6. Curso rápidamente progresivo de Hepatitis por virus C en pacientes con hipogammaglobulina y deficiencia de la inmunidad celular

    OpenAIRE

    Javier Carbone; Elizabeth Sarmiento; Eduardo Fernández-Cruz

    2005-01-01

    El conocimiento de las bases fisiopatológicas de la fibrogénesis en la hepatopatía por virus de la hepatitis C (VHC) es crítico. Describimos la evolución de la infección por VHC tras 10 años de seguimiento en pacientes con inmunodeficiencia de anticuerpos (inmunodeficiencia variable común (n=3) (IDVC), deficiencia de subclases de IgG (n=2), deficiencia específica de formación de anticuerpos (n=1)). Los pacientes fueron tratados con un preparado de inmunoglobulina intravenosa que se asoció pos...

  7. Programas de intervención con menores hijos e hijas de mujeres víctimas de violencia de género

    OpenAIRE

    Pérez Caballero, M. Teresa; Díaz Rosado, Margarita

    2015-01-01

    En el citado seminario informaremos del programa de “atención integral a menores víctimas de violencia de género”, llevado a cabo por la Asociación DEMÉTER. A continuación, trataremos la formación en igualdad y prevención de violencia de género con los estudiantes, mediante charla, cuestionarios sobre conocimientos básicos en prevención de violencia de género, igualdad y menores. Terminaremos con un debate sobre los temas tratados. Universidad de Málaga. Campus de Excelencia Internac...

  8. Propuesta y análisis de un cuestionario complejo, basado en variables relacionadas con el paciente, dirigido a medir la percepción del tratamiento periodonta

    OpenAIRE

    Pulcini, Alberto

    2014-01-01

    Objetivo: Recientemente tanto en la investigación como en la clínica periodontal se ha incrementado el interés por el estudio de las variables centradas en el paciente. El objetivo de este estudio es medir el impacto de la terapia periodontal desde la perspectiva del sujeto tratado mediante la utilización y la organización de un nuevo cuestionario basado en variables relacionados con el paciente(QIPET). Material y Métodos: Se ha realizado un estudio transversal con análisis retrospectivo i...

  9. Ineffectiveness of Nickel in augmenting the hepatotoxicity in protein deficient rats Eficacia del níquel en aumentar la hepatotoxicidad en ratas con deficiencia en proteínas

    Directory of Open Access Journals (Sweden)

    P. Sidhu

    2005-12-01

    deficient animals was also significantly higher when compared to protein deficient animals.Este estudio fue diseñado para determinar los efectos tóxicos del sulfato de níquel sobre el perfil bioquímico y de oligoelementos del hígado en ratas con deficiencia de proteínas.Se administró sulfato de níquel, a la dosis de 800 mg/l, en el agua de bebida de ratas Sprauge Dawley (S-D normales control y con deficiencia de proteínas, durante 8 semanas. Se estudiaron los efectos del tratamiento con níquel y de la deficiencia de proteínas, por separado y en combinación,sobre marcadores enzimáticos hepáticos de la rata como la fosfatasa alcalina (FA, la glutamato oxalacetato transaminasa (GOT, la glutamato piruvato transaminasa (GPT y también el estado de oligoelementos en el hígado de la rata. Las ratas con deficiencia de proteínas, las ratas tratadas con níquel, así cómo aquéllas con la combinación de deficiencia de proteínas y tratamiento con níquel mostraron reducciones significativas en el peso corporal y en el contenido hepático de proteína, en comparación con las ratas normales control. La actividad hepática fosfatasa alcalina y alanina aminotransferasa mostró una elevación significativa en las ratas sometidas a deficiencia de proteínas, a tratamiento con níquel, y a la combinación de deficiencia de proteínas y tratamiento con níquel. Con respecto de las concentraciones hepáticas de aspartato aminotransferasa, se observó una elevación significativa en los animales con deficiencia de proteínas y en aquellos tratado con níquel y con deficiencia de proteínas. La administración de níquel a ratas normales y con deficiencia de proteínas ha producido un aumento significativo de las concentraciones de níquel, fósforo y azufre en el tejido hepático. La concentración de cinc y cobre en el tejido hepático disminuyó significativamente los animales con deficiencia de proteínas, los tratados con níquel, y aquellos con deficiencia de prote

  10. Effect of Aqueous Extract of Cochlospermum Planchonii Rhizome on Some Kidney and Liver Functional Indicies of Albino Rats

    OpenAIRE

    Nafiu, MO; M.A. Akanji; M T Yakubu

    2010-01-01

    Aqueous extract of Cochlospermum planchonii Hook. Ef. x Planch rhizome was investigated for its toxic effects in albino rats using some liver and kidney functional indices as ‘markers’. Thirty six albino rats weighing 200.08 ± 10.21 were randomly assinged into six groups (A–F) of six animals each. Animals in groups A–E were orally administered on daily basis with 1 ml of the extract corresponding to 50 mg/kg body weight of the extract for 1, 3, 5, 10 and 15 days while those in the control gro...

  11. THE POSSIBLE EFFECT OF SILDENAFIL CITRATE AND FENUGREEK SEED POWDER ON ENHANCING SERUM TESTOSTERONE LEVELS IN ADULT MALE ALBINO RATS

    International Nuclear Information System (INIS)

    Sildenafil citrate is a phosphodiesterase 5 inhibitor (PDE5) that increases cyclic guanosine monophosphate (cGMP) which improves vasodilatation and there is a hypothesis that fenugreek seeds have 3 mechanisms by which it may enhance serum testosterone levels. The present study aimed to evaluate the effect of sildenafil citrate and fenugreek seeds alone or in combination on serum testosterone levels in normal adult male albino rats. Besides, total protein, albumin, globulin, bilirubin levels and alanine transaminase, aspartate transaminase and alkaline phosphatase activities were evaluated. The present study claimed that single or combined treatment with sildenafil and fenugreek seed powder (FSP) may enhance serum testosterone levels in adult male albino rats

  12. Evaluation of antinociceptive effect of Xanthium strumarium Linn. leaves extract in Swiss albino mice

    OpenAIRE

    Akarte Atul; Bhagat Vishwas; Deshmukh Pradeep; Disle Chandrakant

    2009-01-01

    The aim of this study was to explore the probable antinociceptive effect of an ethanolic extract of Xanthium strumarium L. leaves in Swiss albino mice by using models of Eddy′s hot plate test, tail immersion test and acetic acid induce writhing test. Swiss albino mice were treated i.p. with saline water (control), test group treated with 50, 100, 200 and 400 mg/kg extract per oral, standard group treated with pentazocin 3 mg/kg. The results are expressed as the mean ± SEM. and...

  13. Skin Cancers Among Albinos at a University Teaching Hospital in Northwestern Tanzania: A Retrospective Review of 64 Cases.

    OpenAIRE

    Mabula Joseph B; Chalya Phillipo L; Mchembe Mabula D; Jaka Hyasinta; Giiti Geofrey; Rambau Peter; Masalu Nestory; Kamugisha Erasmus; Robert Ssentongo; Gilyoma Japhet M

    2012-01-01

    Abstract Background Skin cancers are a major risk associated with albinism and are thought to be a major cause of death in African albinos. The challenges associated with the care of these patients are numerous and need to be addressed. The aim of this study was to outline the pattern and treatment outcome of skin cancers among albinos treated at our centre and to highlight challenges associated with the care of these patients and proffer solutions for improved outcome. Methods This was a ret...

  14. Las aspiraciones cosmpolitas de la ciudadanía europea a la luz del Tratado de Lisboa

    Directory of Open Access Journals (Sweden)

    Jose Antonio García Saez

    2010-01-01

    Full Text Available  En octubre de 2009 se repetirá el referéndum irlandés sobre el Tratado de Lisboa. El accidentado proceso de gestación de este tratado, heredero a su vez de la non nata Constitución Europea, suscita algunas dudas en torno a la concepción de ciudadanía europea que vienen manejando las instituciones de la UE. En el presente artículo se intentará aportar algunos elementos de reflexión sobre esta concepción de ciudadanía tomando como referencia el ideal más amplio de la ciudadanía cosmopolita. Para determinar si la ciudadanía europea está avanzando o no hacia ese ideal cosmopolita se tendrán en cuenta tres cuestiones básicas: 1 la identidad europea, 2 el vínculo entre nacionalidad y ciudadanía y 3 los mecanismos de participación ciudadana y las garantías de legitimidad democrática.

  15. Las aspiraciones cosmpolitas de la ciudadanía europea a la luz del Tratado de Lisboa

    Directory of Open Access Journals (Sweden)

    Jose Antonio García Saez

    2010-01-01

    Full Text Available En octubre de 2009 se repetirá el referéndum irlandés sobre el Tratado de Lisboa. El accidentado proceso de gestación de este tratado, heredero a su vez de la non nata Constitución Europea, suscita algunas dudas en torno a la concepción de ciudadanía europea que vienen manejando las instituciones de la UE. En el presente artículo se intentará aportar algunos elementos de reflexión sobre esta concepción de ciudadanía tomando como referencia el ideal más amplio de la ciudadanía cosmopolita. Para determinar si la ciudadanía europea está avanzando o no hacia ese ideal cosmopolita se tendrán en cuenta tres cuestiones básicas: 1 la identidad europea, 2 el vínculo entre nacionalidad y ciudadanía y 3 los mecanismos de participación ciudadana y las garantías de legitimidad democrática.

  16. Diseñe su interfaz gráfica con Matlab

    Directory of Open Access Journals (Sweden)

    Miguel Ramón Ortegón Gutiérrez

    2011-01-01

    Full Text Available Las aplicaciones de carácter científico o tecnológico cuentan, para su desarrollo, con el apoyo de una poderosa herramienta de cálculo numérico, que permite abordar problemas que demanden variada y compleja manipulación matemática de manera eficiente y con ayudas gráficas. Su diseño funcional le permite usar con facilidad toda la gama de comandos en forma interactiva, o en modo programas que han sido implementados como parte del lenguaje, o los nuevos comandos implementados por el usuario. Problemas tradicionales, relativos al manejo de matrices o álgebra lineal, cálculo diferencial e integral, ecuaciones diferenciales, raíces de funciones, solución de sistemas de ecuaciones, etc., hasta algunos más especializados como el procesamiento digital de señales, redes neuronales, filtros, pueden ser tratados con este lenguaje. Con el presente artículo se desea difundir el uso de interfaces gráficas que provee Matlab, para hacer más modernas, presentables y manejables aplicaciones de ingeniería que con otras herramientas podrían resultar mas complicadas y engorrosas.

  17. Urgencias metabólicas en pacientes críticos con cáncer

    Directory of Open Access Journals (Sweden)

    Silvio A. Ñamendys-Silva

    2013-12-01

    Full Text Available Las alteraciones metabólicas graves que ocurren con frecuencia en pacientes oncológicos críticamente enfermos incluyen: hipercalcemia, hipocalcemia, hiponatremia, síndrome de lisis tumoral, alteraciones metabólicas asociadas a insuficiencia renal y acidosis láctica. Los enfermos oncológicos con urgencias metabólicas deben ser tratados en un departamento de oncología médica o en una unidad de cuidados intensivos. La mayor parte de las urgencias metabólicas se pueden tratar de forma adecuada cuando son identificadas de forma temprana. El clínico debe considerar, que el pronóstico de los pacientes oncológicos críticamente enfermos depende de su enfermedad primaria, las comorbilidades y las fallas orgánicas.

  18. Antioxidant potential of tea reduces arsenite induced oxidative stress in Swiss albino mice.

    Science.gov (United States)

    Sinha, D; Roy, S; Roy, M

    2010-04-01

    Environmental arsenic (As) is a potent human carcinogen and groundwater As contamination is a major health concern in West Bengal, India. Oxidative stress has been one of the prime factors in As-induced carcinogenicity. Generation of reactive oxygen species (ROS), beyond the body's endogenous antioxidant balance cause a severe imbalance of the cellular antioxidant defence mechanism. Tea, a popular beverage has excellent chemopreventive and antioxidant properties. In this study it was investigated whether these flavonoids could ameliorate the arsenite (As III) induced oxidative stress in Swiss albino mice. Bio-monitoring with comet assay elicited that the increase in genotoxicity caused by As III was counteracted by both black tea and green tea. Elevated levels of lipid peroxides and protein carbonyl by As III were effectively reduced with green as well as black tea. They also exhibited protective action against the As III induced depletion of antioxidants like catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST) and glutathione (GSH) in mice liver tissue. Thus the tea polyphenols by virtue of their antioxidant potential may be used as an effective agent to reduce the As III induced oxidative stress in Swiss albino mice. PMID:20096321

  19. Biochemical Effects of Energy Drinks Alone or in Combination with Alcohol in Normal Albino Rats

    Directory of Open Access Journals (Sweden)

    Emmanuel Ike Ugwuja

    2013-12-01

    Full Text Available Purpose: To determine the biochemical effects of energy drink alone or in combination with alcohol in normal albino rats. Methods: Twenty male albino rats weighing 160-180g were assigned into groups A-E of four rats per group. Group A and B rats were given low and high doses of ED, respectively, groups C and D were administered low and high doses of EDmA, respectively while group E rats were given distilled water and served as control. The treatment lasted for 30 days after which the animals were killed and their blood collected for laboratory analyses using standard methods. Results: There were no significant differences in body weight, packed cell volume and haemoglobin concentration with either administration of ED or EDmA in comparison to the control. Energy drink alone or EDmA has significant effects on total white blood cell count, plasma potassium, calcium, renal functions, liver enzymes and plasma triglycerides, with EDmA having more effects than ED alone, except for body weight where the energy drink alone has higher effect. Conclusion: Consumption of energy drink alone or in combination with alcohol is associated with significant alterations in some biochemical parameters. Caution should be exercised while consuming either of them. Public health education is urgently needed to correct the wrong impression already formed by the unsuspecting consumers, especially the youths.

  20. A comparative study on the susceptibility of male and female albino mice to Trypanosoma brucei brucei

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    A.A. Turay, G.O. Nwobu, G.R.A. Okogun, C.U. Igwe, K. Adeyeye, K.E. Aghatise, H.O. Okpal & Y.M. Tatfeng

    2005-03-01

    Full Text Available Background & objectives: Trypanosomiasis has remained a major set-back in the development oflivestock farming in tropical Africa. Thus the need for ascertaining the trypanotolerant levels ofdomestic animal breeds and possible improvement on them cannot be over-emphasised.Methods: Level of trypanotolerance in animals was compared between sexes using albino mice infectedwith a Nigerian strain of Trypanosoma brucei brucei at a 50% mouse lethal dose (MLD50.Results: The male mice showed unrestrained parasite growth with a prepatent period (PP of two daysand a mean survival period (MSP of six days corresponding to a gradual decrease in packed cellvolume (PCV, body weight, diet response and white blood cells (WBC count to the time of death.Their female counterparts showed a PP of three days and MSP of ten days with a similar PCV gradientbut a refractory WBC count. There was no significant difference in the differential leucocytes countin both sexes. However, the eosinophils count was significantly higher in the infected animals. It wasfound that female albino mice exercised more parasite restraint than their male counterparts.Interpretation & conclusion: The result suggests that the female animals may be more trypanotoleranthence may be more useful in protein production in trypanosomiasis endemic areas. However, furtherresearch using large domestic breeds like goats and sheep may be required to confirm the hypothesis.

  1. Assessment of imidacloprid-induced mutagenic effects in somatic cells of Swiss albino male mice.

    Science.gov (United States)

    Bagri, Preeti; Kumar, Vinod; Sikka, Anil K

    2016-10-01

    Pesticides are being used for plant protection to increase food protection and to reduce insect-borne diseases worldwide. Exposure to the pesticides may cause genotoxic effects on both the target and nontarget organisms, including man. Therefore, the mutagenicity evaluation of such pesticides has become a priority area of research. Imidacloprid (IMI), a neonicotinoid insecticide, is widely used in agriculture either alone or in combination with other insecticides. A combined approach employing micronucleus test (MNT) and chromosomal aberrations assay (CA) was utilized to assess the mutagenicity of imidacloprid in bone marrow of Swiss albino male mice. IMI suspension was prepared in 3% gum acacia and administered at doses of 5.5, 11 and 22 mg/kg body weight for 7, 14 and 28 days to mice. IMI treatment resulted in a dose and time-dependant increase in the frequencies of micronuclei per cell and chromosomal aberrations in bone marrow cells. A statistically significant increase in chromosomal aberrations and micronuclei/cell was found only after daily treatment of IMI at highest selected dose (22 mg/kg body weight) for longest selected time period (28 days) compared to the control group. Thus, daily exposure of imidacloprid at a dose level of 22 mg/kg body weight for 28 days caused mutagenic effects on the somatic cells of Swiss albino male mice. PMID:26823062

  2. Ameliorative effect of grapefruit juice on amiodarone-induced cytogenetic and testicular damage in albino rats

    Institute of Scientific and Technical Information of China (English)

    Saber Abdelruhman Sakr; Mohamed El-said Zoil; Samraa Samy El-shafey

    2013-01-01

    Objective:To evaluate the ameliorative role of grapefruit juice on the cytogenetic and testicular damage induced by the antiarrythmic drug amiodarone in albino rats. Methods: Animals were divided into four groups. Group I was considered as control. Group II was given grapefruit juice at a dose level of 27 mL/kg body weight. Group III was orally administered amiodarone (18 mg/kg body weight) daily for 5 weeks. Animals were sacrificed after 5 weeks of treatment. Bone marrow was collected from the femurs for analysis of chromosomal aberrations and mitotic indices. Testes were removed and stained with H&E for histological examination. Sperms were collected from epidedymis for detection of sperm head abnormalities. Comet assay was used to detect DNA damage. Results: Amiodarone treatment caused a significant increase in the percentage of chromosomal aberrations, decreased the mitotic index and increased DNA damage. The testis showed many histopathological alterations, inhibition of spermatogenesis and morphometric changes. The number of sperm head abnormalities was increased. Treating animals with amiodarone and grapefruit juice caused a reduction in chromosomal aberrations, mitotic index, DNA damage and testicular alterations caused by amiodarone. Conclusions:The results of this study indicated that grapefruit juice ameliorates the cytotoxicty and testicular alterations induced by amiodarone in albino rats and this is may be due to the potent antioxidant effects of its components.

  3. Mutation of p53 in skin papilloma and tubular breast adenoma of albino mice

    International Nuclear Information System (INIS)

    Objective: To determine the mutation of p53 in chemically induced carcinogenesis on albino mice in skin papilloma and tubular adenoma breast by immunohistochemistry. Design: An experimental study. Place and Duration of Study: The animal house of Postgraduate Medical Institute and Pathology Department of King Edward Medical College University, Lahore, for the duration of 20 weeks, from 15 February, 2004 to 15 July, 2004. Subjects and Methods: Twenty five albino mice (male and female) were selected for a study on chemical carcinogenesis. These animals were divided into five groups (A-E), five animals in each. DMBA (Dimethylbenz[a] Anthracene) and TPA (Tetradecanoyl-phorbal-13-Acetic Acid) [chemical carcinogens] were given to produce the tumors and mutation of p53 expression was evaluated on the tumors appearing during this period of carcinogenesis. Squamous cell papillomas and tubular adenoma breast were selected for this study. Results: All the papillomas showed faint reactivity for immuno marker p53, while tubular adenomas were nonreactive. Conclusion: The results of this study show that p-53 is a marker for pre malignant lesions and helps in selecting patients for constant monitoring, upon the clinical verification of these results. (author)

  4. Immunomodulatory Activity of Vetiveria zizanioides Extract on Peritonial Macrophages of Albino Mice

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    Sunitha VS

    2015-12-01

    Full Text Available Vetiveria zizanioides L. (Poaceae is a medicinal plant which is used as a thirst quencher in southern part of India especially in Kerala. The present study was conducted to scientifically evaluate the effects of extracts of V. zizanioides on phagocytic function of macrophages. In vivo effect of aqueous, ethanol and hexane extract of the plant at two doses (10mg/kg body weight and 25mg/kg b.w. were evaluated by oral administration of the extracts on Swiss albino male mice. In vitro immunomodulatory potential of the above extracts at different concentrations (10μg/ml, 25μg/ml, 50 μg/ml and 100μg/ml was studied using peritoneal macrophages from Swiss albino mice. All extracts gave phagocytic modulation in vivo. The aqueous extract of vetiveria zizanoides at a dose of 25mg/kg b.w. showed significant (p<0.05 increase in phagocytic activity in comparison with the control. An increased phagocytic response was shown by murine peritoneal macrophages after treatment with the extracts in vitro. A dose dependent response was observed in all cases. The results of the present study indicate the immunomodulatory effect of V. zizanioides extracts on murine peritoneal macrophages, as evidenced by its effect on phagocytosis which is a nonspecific immune mechanism.

  5. Amelioration of cisplatin induced nephrotoxicity in Swiss albino mice by Rubia cordifolia extract

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    Joy Jisha

    2008-01-01

    Full Text Available Background: Cisplatin is one of the most effective chemotherapeutics against a wide range of cancers including head, neck, ovarian and lung cancers. But its usefulness is limited by its toxicity to normal tissues, including cells of the kidney proximal tubule. The purpose of the present study is to investigate whether the hydro-alcoholic extract of Rubia cordifolia could decrease the intensity of toxicity in Swiss albino mice. Materials and Methods: Cisplatin at a dose of 12 mg/kg body wt was administered intraperitoneally to Swiss albino mice. Another set of animals was given hydro-alcoholic extract of Rubia cordifolia at different doses along with cisplatin treatment. The antioxidant levels, serum creatinine, serum urea etc. were analyzed. Results: The extract could significantly decrease the cisplatin induced nephrotoxicity as inferred from the tissue antioxidant status in the drug administered animals. Remarkable change was observed in serum creatinine and urea levels. Lipid peroxidation in the kidney and liver tissues was also considerably reduced in Rubia cordifolia extract treated animals. Conclusion: Hydro-alcoholic extracts of Rubia cordifolia are effective in reducing the renal damage caused by the cancer chemotherapeutic drug cisplatin. Since Rubia cordifolia has been in use as an important ingredient in the traditional Ayurvedic system of medicine, it could be safe and beneficial to use this herbal extract as an adjuvant to ameliorate renal damage in patients undergoing cancer chemotherapy with cisplatin.

  6. Dietary Antioxidants Effectiveness on Carbon Tetrachloride-Induced Hepatotoxicity in Adult Female Albino Rats

    International Nuclear Information System (INIS)

    Hepatic toxicity through carbon tetrachloride (CCI4) induced lipid peroxidation was extensively used in experimental models to understand the cellular mechanisms behind oxidative damage and to evaluate the therapeutic potential of drugs and dietary antioxidants. The ameliorative effect of Aloe vera juice and carrot supplementation on hepato carcinogenesis induced by carbon tetrachloride in adult female albino rats was investigated. The carcinogenic process was determined by measuring gamma-glutamyl transpeptidase (GGT), ornithine carbamyl transferase (OCT), thiobarbituric acid reactive substances (TBARs), representing levels of lipid peroxides, and carcinoembryonic antigen (CEA) in the sera of female albino rats. Carbon tetrachloride significantly elevated the serum GGT, OCT activities and the level of TBARs. Administration of Aloe vera leaf juice filtrate after CCl4 treatment resulted in a non-significant modification in GGT, OCT activities and significantly improved the level of TBARs in comparison with control. Supplementation of carrot to CCI4 treated animals led to a great amelioration in OCT activity and TBARs level, whereas GGT activity was ameliorated but statistically changed compared to control. There was a non-significant alteration in the level of CEA in all treated groups compared to normal control one

  7. Histological and Physiological Alterations Induced by Thermal Neutron Fluxes in Male Swiss Albino Mice

    International Nuclear Information System (INIS)

    This work was performed to investigate the biological effects of different thermal neutron fluxes (0.27x108, 0.52X108, 1.089X108, 2.16X108 and 4.32X108) on liver and kidney of male mice using neutron irradiation cell with Ra-Be(α,n) 3 mCi neutron source Leybold (55930). Exposed to various fluxes of thermal neutron induced a dramatic alterations in hepatic and renal functions as indicated by biochemical estimation of several parameters (bilirubin, SGT, and alkaline phosphate .Urea , total protein, and albumin) and confirmed by histological examinations Thermal neutron exposure induces marked increase in the serum activities of total bilirubin, alanine amino transaminase (ALT or GPT), and alkaline phosphate, whereas, urea, total protein and albumin showed marked decline as compared to control group. The physiological changes induced in thermal neutron fluxes dependent manner. Histopathological results revealed mild to severe type of necrosis, and degenerative changes in liver and kidney of male mice exposed to thermal neutron fluxes. Also it was found that the histopathological alterations induced in thermal neutron fluxes dependent manner. It was found that exposed to thermal neutron fluxes irradiation plays prominent role in the development of the physiological alterations in male Swiss albino mice. The Former up normalities as a result of the sequence events followed interaction of radiation with the former biological mater (liver and kidney) of male Swiss albino mice, which are, physical, physicochemical, chemical, and biological stages.

  8. Impact on behavioral changes due to chronic use of sertraline in Wistar albino rats

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    Shatavisa Mukherjee

    2015-01-01

    Full Text Available Aim: Despite having better tolerability and a wide range of clinical applications over other antidepressants, selective serotonin reuptake inhibitors (SSRIs are also known to be associated with serious adverse effects like suicidal ideation on chronic use. The present study had explored the impact of the chronic use of sertraline, an SSRI, on the behavioral changes in Wistar albino rats. Materials and Methods: The study was conducted on 30 Wistar albino rats of either sex; divided into five groups. Four groups were subjected to chronic mild stress induced by using various stressors randomly scheduled in a week and continued for a period of 3 weeks. The stressed rodents were subjected to sertraline treatment for 9 weeks in different human therapeutic doses extrapolated to animal doses. Behavioral changes were monitored, assessed, and evaluated throughout the treatment phase with the help of tests such as locomotor activity test, forced swim test, tail suspension test, antianxiety test, and sucrose preference test (SPT. Results: All tests except SPT, demonstrated significant (P < 0.05 reduction in depressive-like activity in the stressed rodents by the mid-treatment phase, followed by an abrupt onset of the depressive state by the end of the treatment phase. SPT showed a significant (P < 0.05 increase in sucrose consumption throughout the treatment phase. Conclusion: Behavioral changes following chronic sertraline administration conferred gradual remission of depression state on initial treatment phase, followed by a reversal of effect on chronic use.

  9. Acute effect of aspartame-induced oxidative stress in Wistar albino rat brain.

    Science.gov (United States)

    Ashok, Iyaswamy; Sheeladevi, Rathinasamy; Wankhar, Dapkupar

    2015-09-01

    The present study was carried out to investigate the acute effect of aspartame on oxidative stress in the Wistar albino rat brain. We sought to investigate whether acute administration of aspartame (75 mg/kg) could release methanol and induce oxidative stress in the rat brain 24 hours after administration. To mimic human methanol metabolism, methotrexate treated rats were used to study aspartame effects. Wistar strain male albino rats were administered with aspartame orally as a single dose and studied along with controls and methotrexate treated controls. Blood methanol and formate level were estimated after 24 hours and rats were sacrificed and free radical changes were observed in discrete regions by assessing the scavenging enzymes, reduce dglutathione (GSH), lipid peroxidation and protein thiol levels. There was a significant increase in lipid peroxidation levels, superoxide dismutase activity (SOD), glutathione peroxidase levels (GPx), and catalase activity (CAT) with a significant decrease in GSH and protein thiol. Aspartame exposure resulted in detectable methanol even after 24 hours. Methanol and its metabolites may be responsible for the generation of oxidative stress in brain regions. The observed alteration in aspartame fed animals may be due to its metabolite methanol and elevated formate. The elevated free radicals due to methanol induced oxidative stress. PMID:26445572

  10. Traffic Noise: A Silent Killer of Male Gamate of Albino Rats

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    Purushottam Pramanik , Snehangshu Biswas

    2012-01-01

    Full Text Available Objectives: The study aims to estimate the change in the weight of testis, sperm count, sperm morphology, testicular cholesterol and protein level in acute and chronic traffic noise exposed albino rats. Background: Road traffic is a significant source of noise pollution, a type of environmental stress. Traffic noise significantly increases adrenal cortical function and causes testicular dysfunction. Method: Experiment was performed on adult male albino rats. Animals were divided in to one control group and two experimental groups. Both the experimental groups were exposed to traffic noise having intensity 80 dB to 90 dB at the rate of 5 hr daily and control group was not exposed. First experimental group was exposed to traffic noise for 30 days and second group for 60 days. Testicular weight, sperm count, sperm morphology, testicular protein level and testicular cholesterol level were estimated. Statistical analysis was done using unpaired ‘t’ test. Result: Contribution of testis to body weight, testicular protein level and sperm count were low but testicular cholesterol level was more in traffic noise exposed rats than unexposed counterpart. Traffic noise exposure also increased percentage of morphologically abnormal sperm. Conclusion: Traffic noise adversely affect male gamete and such effect may be due to noise-induced suppression of testosterone synthesis.

  11. HAIR GROWTH POTENTIAL OF EVOLVULUS ALSINOIDES LINN. PLANT EXTRACT IN ALBINO RATS

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    Bhaiji Amrita

    2012-05-01

    Full Text Available Evolvulus alsinoides Linn. (Convolvulaceae is traditionally used for its hair growth promoting activity in rural community of Indian sub-continent. Studies were therefore carried out to evaluate petroleum ether and methanolic extracts of Evolvulus alsinoides for their effect on hair growth in albino rats. The extracts were incorporated into oleaginous base and applied topically on shaved denuded skin of albino rats for thirty days. The time required for hair growth initiation and completion was significantly (P < 0.01 reduced. Minoxidil 2% solution applied topically served as positive control. The treatment was successful in bringing 73% of hair follicles in anagenic phase by application of 5% methanolic extract as comparable to standard. Bioactivity guided fractionation was carried out of methanolic extract and was fractionated as aqueous and non-aqueous extract and screened pharmacologically. Water insoluble methanolic extract was found to be more potent and reduced the hair growth initiation and completion time significantly (P < 0.01 as comparable to standard. It holds the promise of potent alternative for minoxidil.Keywords:

  12. Biochemical and immunological changes on oral glutamate feeding in male albino rats

    Science.gov (United States)

    Kumar, D.; Bansal, Anju; Thomas, Pauline; Sairam, M.; Sharma, S. K.; Mongia, S. S.; Singh, R.; Selvamurthy, W.

    High altitude stress leads to lipid peroxidation and free radical formation which results in cell membrane damage in organs and tissues, and associated mountain diseases. This paper discusses the changes in biochemical parameters and antibody response on feeding glutamate to male albino Sprague Dawley rats under hypoxic stress. Exposure of rats to simulated hypoxia at 7576 m, for 6 h daily for 5 consecutive days, in an animal decompression chamber at 32+/-2° C resulted in an increase in plasma malondialdehyde level with a concomitant decrease in blood glutathione (reduced) level. Supplementation of glutamate orally at an optimal dose (27 mg/kg body weight) in male albino rats under hypoxia enhanced glutathione level and decreased malondialdehyde concentration significantly. Glutamate feeding improved total plasma protein and glucose levels under hypoxia. The activities of serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) and the urea level remained elevated on glutamate supplementation under hypoxia. Glutamate supplementation increased the humoral response against sheep red blood cells (antibody titre). These results indicate a possible utility of glutamate in the amelioration of hypoxia-induced oxidative stress.

  13. Effect of imatinib on the biochemical parameters of the reproductive function in male Swiss albino mice

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    A M Prasad

    2011-01-01

    Full Text Available Background: Treatment of cancers with cytotoxic agents such as tyrosine kinase inhibiting drugs often, but not always, result in transient to permanent testicular dysfunction. Germ cells are important targets of many chemicals. Most of the drugs are genotoxins and induce irreversible effect on genetic makeup. These mutagenic changes are proportionally related to carcinogenesis. This is alarmingly dangerous in youth and children, since these effects last longer, affecting fertility or forming basis for carcinogenesis. There is paucity of reports on planned studies of imatinib on the testicular function. Hence, the study was planned to assess the effects of imatinib on biochemical markers of testicular functions in male Swiss albino mice. Materials and Methods: Male Swiss albino mice were treated with imatinib and sacrificed at the end of first, second, fourth, fifth, seventh, and tenth week after the last exposure to imatinib. The testis were removed, weighed, and processed for biochemical analysis. Results: The intratesticular testosterone level was significantly (P<0.001 reduced in treated groups and severe effect was observed on week 4 and 5. The intratesticular lactate dehydrogenase (LDH level was significantly increased by imatinib in all treated groups up to week 5. Conclusion: Imatinib does affect testosterone and LDH level significantly, but this effect is reversible once the drug is withdrawn. This finding may help the clinicians to plan and address the fertility-related issues in young patients of reproductive age who are being treated with imatinib for gastrointestinal tumors and chronic myeloid leukemia.

  14. Effect of Some Antioxidants on the Physical Fitness of Albino Rats

    International Nuclear Information System (INIS)

    In recent years, more attention has been paid for searching of natural antioxidants and their evaluation in either medicinal practice or as food raw materials. The aim of the present research is to assess the effect of several well-known products used as antioxidants, on body weight, haemopoesis, endocrine system and lipid profile in normal albino rats. Thirty male adult albino rats were equally arranged into 5 groups, the first group was served as control and the others received special treatments where taurine (2% in drinking water), tryptophan (100 mg/kg b.w. orally), hawthorn extract (50 mg/100 g b.w. orally) and coenzyme Q10 (50 mg/kg b.w. orally) were given for two months. Body weight was regularly recorded twice a week and at the end of the experiment, the rats were decapitated. Red blood cell count (RBCs), hemoglobin (Hb) content, reticulocytic count, white blood cell count (WBCs) and glutathione (GSH) concentration were estimated in blood, while, triiodothyronine (T3), thyroxin (T4), Testosterone, and corticosterone hormones besides lipid profile were estimated in the serum. The results denoted that although there is a slight improvement in the parameters tested, it does not deserve the coast of the regular use of these antioxidants and further investigations still needed

  15. Effect of chronic exposure to aspartame on oxidative stress in the brain of albino rats

    Indian Academy of Sciences (India)

    Ashok Iyyaswamy; Sheeladevi Rathinasamy

    2012-09-01

    This study was aimed at investigating the chronic effect of the artificial sweetener aspartame on oxidative stress in brain regions of Wistar strain albino rats. Many controversial reports are available on the use of aspartame as it releases methanol as one of its metabolite during metabolism. The present study proposed to investigate whether chronic aspartame (75 mg/kg) administration could release methanol and induce oxidative stress in the rat brain. To mimic the human methanol metabolism, methotrexate (MTX)-treated rats were included to study the aspartame effects. Wistar strain male albino rats were administered with aspartame orally and studied along with controls and MTX-treated controls. The blood methanol level was estimated, the animal was sacrificed and the free radical changes were observed in brain discrete regions by assessing the scavenging enzymes, reduced glutathione, lipid peroxidation (LPO) and protein thiol levels. It was observed that there was a significant increase in LPO levels, superoxide dismutase (SOD) activity, GPx levels and CAT activity with a significant decrease in GSH and protein thiol. Moreover, the increases in some of these enzymes were region specific. Chronic exposure of aspartame resulted in detectable methanol in blood. Methanol per se and its metabolites may be responsible for the generation of oxidative stress in brain regions.

  16. Stable Cesium Toxicity and Effect of Prussian Blue in Growing Male Albino Rats

    International Nuclear Information System (INIS)

    The present study was carried out to asses the toxicological effects of stable cesium chloride (CsCl) on growing male albino rats and to evaluate the therapeutic role of Prussian blue (PB) administration for modification of the chemical toxicity. The experiments were performed on 32 growing male albino rats, (Rattus Rattus), divided into control group and three groups administered a daily dose of CsCl or PB or both. The results revealed that the intake of stable cesium chloride caused a significant decrease in the Hb concentration, Ht %, serum folic acid, vitamin B12, potassium levels and body weight gain, with significant increase in WBC's count, serum urea and creatinine. No effect was observed on the other studied parameters including: RBCs count, liver functions, blood glucose, phosphokinase, and lactate dehydrogenase. On the other hand, PB caused a significant amelioration in the changes produced by CsCl with variable degrees leading to the conclusion that it can be one of the therapeutic agents that might provide a protection against toxicological effects

  17. Evaluation of antinociceptive effect of Xanthium strumarium Linn. leaves extract in Swiss albino mice

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    Akarte Atul

    2009-01-01

    Full Text Available The aim of this study was to explore the probable antinociceptive effect of an ethanolic extract of Xanthium strumarium L. leaves in Swiss albino mice by using models of Eddy′s hot plate test, tail immersion test and acetic acid induce writhing test. Swiss albino mice were treated i.p. with saline water (control, test group treated with 50, 100, 200 and 400 mg/kg extract per oral, standard group treated with pentazocin 3 mg/kg. The results are expressed as the mean ± SEM. and statistically analyzed using one-way analysis of variance (ANOVA followed by a Student-Newman-keuls test for multiple comparisons using Graph Pad Instant statistical program. Values of p < 0.05 were considered to be significant. The ethanolic extract showed the dose-dependent antinociceptive activity in Eddy′s hot plate test, tail immersion test and acetic acid induce writhing test at time intervals 15, 30, 60 and 120 min.

  18. Antioxidant activity of eggplant (Solanum melongena) in male albino rats exposed to gamma irradiation

    International Nuclear Information System (INIS)

    The aim of the study was to evaluate the potential benefits of dietary supplementation of eggplant (Solanum melongena) as antioxidant against γ- rays-induced biochemical changes in male albino rats by estimating some of the components of antioxidant defense in the; liver glutathione content (GSH), superoxide dismutase activity (SOD) and malondialdehyde (MDA), serum aspartate amino transferase,(AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), gamma glutamyl transaminase (GGT), cholesterol, triglycerides, low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol(HDL-C). Male albino rats (120-150 g) were divided into four groups as Control group, group 2 received diet supplemented with 10% of eggplant (Solanum melongnea) fruit for 21 successive days , group 3: irradiated with a single dose (6.5 Gy), group 4 received eggplant for 21 successive days then exposed to 6.5 Gy. All animals were sacrificed after 1, 3 and 8 days post irradiation. Rats exposed to γ-rays exhibited a profound elevation of AST, ALT, ALP and GGT activities, and lipid abnormalities .Noticeable drop in liver GSH content and SOD activity associated with increase of MDA was recorded. Treatment with dietary eggplant for 21 days before irradiation significantly abolished radiation induced elevations in MDA and significantly elevates hepatic GSH content and SOD activity. The levels of cholesterol, TG, HDL-C, LDL-C as well as the activities of AST, ALT, and GGT in serum were significantly ameliorated and noticeable improvement in the lipid profile levels

  19. The protective role of damsissa (Ambroosia Maritima) against gamma irradiation in albino rats

    International Nuclear Information System (INIS)

    The present work was directed to evaluate the effectiveness of treatment with damsissa (Ambrosia maritima) for thirty consecutive days pre- irradiation exposure in controlling the post-irradiation hazards in irradiated rats. Male albino rats (Spraue Dowley strain) weighing about 120+- 10 g were used and blood samples were collected from tails of animals thirty days after treatment with damsissa and seven days post irradiation. Blood samples were subjected to biochemical analysis such as liver functions, kidney function and lipid profile. Whole body gamma irradiation of rats at 6 Gy (single dose) caused significant decrease in the contents of total proteins accompanied by significant increase of urea level as recorded on the 7th days post irradiation. Data obtained in this study revealed that whole body gamma irradiation induced significant elevation in all tested blood lipid functions. There was significant increase of aspartate amino transferase (AST) and alanine amino transferase (ALT) whole alkaline phosphatase (ALP) showed statistical significant decrease as compared with the control group. Damisissa (Ambrosia maritima) treatment exerted noticeable amelioration in the the studied biochemical parameters of the irradiated albino rats. The mechanism of action of damsissa may be due to its anti-inflammatory properties against whole body gamma irradiation

  20. The Protective Role of Ginger (Zingiber Officinales ) in Male Albino Rats Exposed to Gamma Irradiation

    International Nuclear Information System (INIS)

    The present work was performed to evaluate the effectiveness of preirradiation treatment with ginger (Zingiber Officinales) for 21 consecutive days before exposure in controlling post-irradiation hazards in male rats. Male albino rats weighing about 120±10 g were divided into four groups: ( I ) control, ( II ) treated with ginger 200 mg/kg , ( III ) irradiated with 6 Gy and ( IV ) treated with ginger 200 mg/kg before irradiated with 6 Gy gamma - radiation . The blood samples were collected from heart of animals 21 days after treatment with ginger and seven days post irradiation. Blood samples were subjected to biochemical analysts such as liver functions , lipid profile , kidney function and sex hormone. Whole body gamma irradiation of rats at 6 Gy (single dose) caused significant increase in (aspartate and alanine aminotransferases (AST and ALT), cholesterol, triglycerides , glucose, urea and creatinine) while alkaline phosphatase showed no effect. Irradiation caused decrease in the contents of total protein , albumin and testosterone. Ginger treatment exerted noticeable amelioration in the studied biochemical parameters of the irradiated albino rats. The mechanism of action of ginger may be due to its antiinflammatory properties against whole body gamma irradiation

  1. Effect of GABAB Receptor Antagonist (CGP35348 on Learning and Memory in Albino Mice

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    Quratulane Gillani

    2014-01-01

    Full Text Available The present study was designed to demonstrate the potential effect of CGP 35348 (GABAB receptor antagonist on the learning, memory formation, and neuromuscular coordination in albino mouse. Mice were intrapertoneally injected with 1 mg CGP 35348/mL of distilled water/Kg body weight, while the control animals were injected with equal volume of saline solution. A battery of neurological tests was applied following the intrapertoneal injections. Results of rota rod indicated that CGP 35348 had no effect on neuromuscular coordination in both male (P=0.528 and female (P=0.125 albino mice. CGP 35348 treated females demonstrated poor exploratory behavior during open filed for several parameters (time mobile (P=0.04, time immobile (P=0.04, rotations (P=0.04, and anticlockwise rotations (P=0.038. The results for Morris water maze (MWM retention phase indicated that CGP 35348 treated male mice took shorter latency to reach the hidden platform (P=0.04 than control indicating improved memory. This observation was complemented by the swim strategies used by mice during training days in MWM as CGP 35348 treated males used more direct and focal approach to reach the platform as the training proceeded.

  2. Modificación de biomarcadores histopatológicos e inmunohistoquímicos en las fibras musculares de cerdos tratados con clenbuterol

    OpenAIRE

    AM Molina; Blanco, A.; MR Moyano

    2012-01-01

    El clenbuterol frecuentemente se ha utilizado de forma ilícita en el engorde del ganado, suponiendo ello un riesgo para la salud pública. La actual normativa prohíbe por tanto su uso en la cría del ganado. En este estudio se utilizaron 14 cerdos distribuidos al azar en dos grupos de estudio (n=7), uno control, y otro expuesto a 1 mg/kg de clenbuterol durante tres meses. Se utilizó el músculo longissimus lumbaris para la determinación de la concentración de clenbuterol, así como para la evalua...

  3. Resistencia antimicrobiana en aislados de "Escherichia coli" de conejos tratados por vía oral con diferentes pautas de doxiciclina

    OpenAIRE

    Medina Landaeta, Alberto Enrique

    2011-01-01

    La resistencia a antimicrobianos constituye actualmente un problema de gran impacto en Salud Pública. El excesivo uso de antimicrobianos en medicina humana y veterinaria y en agricultura ha originado un incremento continuo de fracasos en la terapia antimicrobiana debido al aumento y diversidad de microorganismos resistentes. La evaluación del riesgo del desarrollo de resistencias cobra especial interés cuando se utilizan pautas de administración por vía oral en animales de abasto, por cuan...

  4. Estudio del virus JC, agente causal de la leucoencafalopatía multifocal progresiva, en pacientes de esclerosis múltiple recurrente-remitente tratados con Natalizumab

    OpenAIRE

    Domínguez Mozo, María Inmaculada

    2013-01-01

    La esclerosis múltiple (EM) es una enfermedad desmielinizante inflamatoria crónica que afecta al sistema nervioso central (SNC) y cuyo origen es presumiblemente autoinmune, siendo en los países desarrollados la segunda causa de discapacidad entre personas jóvenes después de los accidentes de tráfico. Durante los últimos años se han desarrollado, o actualmente están en ensayo clínico, una gran cantidad de fármacos para tratar esta patología. Entre todos ellos cabe destacar natalizumab, u...

  5. Los menores no punibles : ¿Resulta compatible su situación legislativa con la constitución nacional y tratados internacionales incorporados a ella?

    OpenAIRE

    Anselmino, Valeria L.

    2014-01-01

    El fenómeno de la mal llamada “Delincuencia de Menores” no deja de ser portada de diarios y revistas, como así tampoco es ajena al tratamiento doctrinario y legislativo. La vida moderna muestra a nuestros jóvenes una serie de expectativas y objetivos, de difícil acceso a través de los medios convencionales. La sensación de frustración y de falta de incentivos en que los mismos se ven envueltos resultan el empujón final hacia el camino del delito. A lo que se suma la crisis de la familia, e...

  6. Chemical variations observed in irradiated, treated with IPC and control potato tubers; Variaciones quimica observadas en tuberculos de patata irradiados, tratados con IPC y testigo

    Energy Technology Data Exchange (ETDEWEB)

    Mazon Matanzo, M. P.; Fernandez Gonzalez, J.

    1976-07-01

    The content in soluble sugars, ascorbic acid and phenolic acids of potato tubers preserved by irradiation and IPC, during storage period of five months are studied. In the irradiated tubers, soluble sugars increased immediately after the irradiation, in relation to the control tubers reaching inferior values to those reached by the control tubers, at the end of the storage period. The content in ascorbic acid is generally kept higher in the irradiated and IPC treated tubers than in the control tubers and the content in phenolic acids increased in the irradiated and IPC treated tubers by immediate effect of this treatment. (Author) 39 refs.

  7. con marcos extradensos

    Directory of Open Access Journals (Sweden)

    Manuel Rodríguez

    2007-01-01

    Full Text Available El cultivo del plátano vianda al igual que el de la papaya, en la región occidental del país, son fuertemente atacados por enfermedades que hacen que las plantaciones, por el grado de deterioro que estas les producen, no duren más de un ciclo de cultivo. Sembrar una misma área, un año tras de otro con el mismo cultivo, trae consigo el establecimiento en el suelo de elementos parásitos dañinos al mismo, que pueden ser eliminados o atenuados con una rotación con otro cultivo. El presente trabajo expone los resultados experimentales de dos años de trabajo de la rotación de estos cultivos, plantados con dos marcos de plantación de alta densidad, 2 x 4 x 1 m y 3 x 1 m, con una densidad de 3333 plantas/ha y regados con la técnica de riego por goteo. Se obtuvieron rendimientos de 40,73 t/ha en plátano y de 71,42 t/ha en papaya, con una relación beneficio costo de 1,15, tasa interna de retorno de 36,27 %, valor actual neto de 21,47 y plazo de recuperación de la inversión de 3,01 años.

  8. Evaluación urodinámica con doxazocina en pacientes con hiperplasia prostática benigna (HPB. Hospital Pablo Tobón Uribe (HPTU de 1998-1999

    Directory of Open Access Journals (Sweden)

    Juan Aristizábal

    2001-04-01

    Full Text Available

    Tradicionalmente la HPB ha sido tratada quirúrgicamente, pero a
    partir de los años 80 ha aparecido una gran variedad de modalidades
    terapéuticas diferentes a la cirugía, basadas en medicamentos orales que disminuyen el tamaño de la próstata y/o los síntomas que esto genera.
    Se propone estudiar con todos los parámetros urodinámicos, la respuesta de los pacientes con HPB tratados con Doxazocina para evaluar su efecto en las curvas Flujo-Presión.

     

     

  9. Manufactura de limas endodonticas con diseño protaper universal con técnica combinada de prototipado rápido y cera perdida en la aleación níquel, cromo, molibdeno

    OpenAIRE

    Alayón Vargas, Miguel Alfredo

    2015-01-01

    Con la introducción de los instrumentos de Níquel Titanio se han disminuido la cantidad de errores durante la conformación y limpieza de los conductos radiculares, disminuyendo la cantidad de instrumentos necesarios así como el tiempo necesario requerido para el procedimiento. Sin embargo uno de los problemas más frecuentes es la fractura de los instrumentos dentro de los canales radiculares disminuyendo el pronóstico de los dientes tratados endodonticamente. Actualmente no exi...

  10. Modulación de la actividad dopa-decarboxilasa central evaluada mediante PET con 18-F-dopa inducida por la administración crónica de levodopa en macacos con parkinsonismo inducido por MPTP

    OpenAIRE

    M. Riverol; Luquin, M R

    2013-01-01

    La enfermedad de Parkinson (EP) es una entidad frecuentre que afecta fundamentalmente a personas de edad avanzada. Los fármacos más utilizados para el control de los síntomas de esta entidad son la levodopa y los agonistas dopaminérgicos. Diversos estudios de tomografía de emisión de positrones (PET) con 18F-fluorodopa y DAT-scan realizados en pacientes tratados han mostrado, que tras 5 años dde tratamiento, la actividad dopa-descarboxilasa y del transportador de dopamina, fue mayor en los pa...

  11. Modelo conceptual de datos difusos de triaje para emergencia hospitalaria representado con FuzzyEER

    Directory of Open Access Journals (Sweden)

    Wuilfredo Rangel

    2010-05-01

    Full Text Available El triaje de emergencia persigue desarrollar el proceso de valorización clínica preliminar para ordenar los pacientes según el nivel de urgencia o gravedad, antes de la atención médica, de forma que en una condición de saturación del servicio o disminución de recursos, los pacientes más graves sean tratados con prioridad. Un proceso de triaje presenta un alto grado de imprecisión o incertidumbre al momento de expresar el estado de salud de un paciente, en consecuencia puede haber dificultad y riesgo en la clasificación de las urgencias. En los servicios de emergencias de loshospitales públicos venezolanos, en especial el servicio de emergencia del Hospital Universitario de Caracas (HUC, seha evidenciado un incremento en el número de casos que se atienden, siendo una constante la saturación del servicio, lo cual imposibilita que los pacientes con prioridad de atención, sean tratados más rápidamente de forma oportuna y eficaz. En este trabajo se propone un modelo conceptual de datos difuso de triaje para el sector salud venezolano basado en el proceso de triaje hospitalario de la Sociedad Venezolana de Medicina de Emergencia y Desastres (SVMED, ya que un modelo de datos que contemple la representación de atributos difusos puede representar de mejor forma los requerimientos del sistema. El modelo propuesto utiliza la notación Entidad Relación con elementos difusos (FuzzyEER para la representación de las entidades y atributos con imprecisión. Dicho modelo será la base de un sistema automatizado de triaje que hará uso del lenguaje de consultas difusas FSQL (Fuzzy SQL.

  12. Cirugía preprotésica e implantológica en pacientes con atrofia maxilar severa

    OpenAIRE

    R. González García; Naval Gias, Luis; Mario F. Muñoz Guerra; Sastre Pérez, Jesús; F.J. Rodríguez Campo

    2005-01-01

    Objetivos. Valoración del éxito en la osteointegración de los implantes dentales en pacientes con atrofia maxilar severa sometidos a cirugía de elevación de seno maxilar y técnica por aposición mediante el uso de injertos de hueso autólogo. Diseño del estudio. Se realiza estudio descriptivo y analítico de 27 pacientes con atrofia maxilar severa y edentulismo parcial o total, durante 4 años de seguimiento. Todos los casos fueron tratados mediante cirugía con utilización de injertos óseos autól...

  13. Neuropatía óptica por radiación: tratamiento combinado con corticoides y anti-VEGF.

    OpenAIRE

    Vanesa Rivero Gutiérrez; Maria Jesus Aparicio Hernandez-Lastras; Marta Suarez Leoz

    2015-01-01

    Caso Clínico: Varón 71 años diabético y fumador, tratado con braquiterapia por melanoma coroideo. A los dos años presenta una neuropatía óptica por radiación y trombosis venosa contralateral. Se trata con corticodes subtenonianos y posteriormente, se interviene de cataratas y se introduce antiangiogénico intravitreo, con buen resultado. Discusión: La neuropatía óptica por radiación  es una vasculopatía progresiva y crónica secundaria a una radiación ionizante supraumbral. Ocurre cuando la dos...

  14. Evaluación del efecto del tratamiento ocular con Genipín in vivo, en conejos

    OpenAIRE

    Narváez Peñafiel, Mauricio Esteban

    2012-01-01

    Objetivo: Evaluar los efectos del entrecruzamiento del colágeno con genipín en ojos de conejo in vivo en términos de seguridad y toxicidad Métodos: Se aplicó genipín tópico al 0,25% a ojos de 20 conejos hembras raza nueva Zelanda, un ojo tratado el otro como control, divididos en dos grupos, en el primero, conejos adultos la aplicación fue tópica sobre la córnea, en el segundo, conejos en etapa de crecimiento, la aplicación fue subtenoniana. Se realizaron medidas de diferentes variables ta...

  15. Biorremediación de un suelo con diesel mediante el uso de microorganismos autóctonos

    OpenAIRE

    ARRIETA RAMÍREZ OLGA MARIA; RIVERA RIVERA ANGELA PATRICIA; ARIAS MARIN LIDA; ALBERTO ROJANO BENJAMÍN; RUIZ ORLANDO; CARDONA GALLO SANTIAGO ALONSO

    2012-01-01

    En este estudio, se aisló y caracterizó bioquímica y molecularmente un consorcio bacteriano capaz de degradar los diferentes hidrocarburos presentes en un combustible diesel,conformado por los siguientes géneros: Enterobacter sp, Bacillus sp, Staphylococcus aureus, Sanguibacter soli, Arthrobacter sp y Flavobacterium sp, a partir de un suelo contaminado con diesel a escala de laboratorio, y tratado mediante 2 tecnologías de biorremediación: atenuación natural y bioestimulación. Se definió como...

  16. Estudio de la integración visuomotora en niños con altas capacidades intelectuales

    OpenAIRE

    Gaona Bosque, Sara

    2011-01-01

    A lo largo de los años diversos autores han tratado de demostrar que los niños superdotados -actualmente denominados como niños con “altas capacidades intelectuales”- además de tener una mayor capacidad intelectual destacan también por poseer otras habilidades superiores, como por ejemplo, mayor desarrollo cognitivo, mayor capacidad creativa, niveles superiores de percepción, etc. En el presente estudio tratamos de determinar si también poseen una mejor integración visuomotora. Entendiendo la...

  17. Shelf life of peaches treated with 1-methylcyclopropene Vida útil de pêssegos tratados com 1-metilciclopropeno

    Directory of Open Access Journals (Sweden)

    Ricardo Alfredo Kluge

    2002-03-01

    Full Text Available Peaches [Prunus persica (L. Bastch] present reduced post-harvest shelf life, partially, due to their high respiratory rate and fast ripening. These processes are related to ethylene production, as well as its action. Peaches, cv. Aurora-1, were picked at two different ripening stages (mature green and ripe and treated with 1-methylcyclopropene (1-MCP, the ethylene's competitive antagonist, at concentrations of 0, 100, 300 and 900 nL L-1 for 12 hours at 25ºC. After treatment, the fruits were stored at room temperature (25ºC for six days. Fruits treated with 1-MCP presented better firmness and less ground color loss than non-treated fruits. The 1-MCP antagonist reduced the development of fruit rot at the mature green stage, but not at the ripe one. The 1-MCP shows commercial application potential in the treatment of peaches in order to delay the ripening process and increase their shelf life.Pêssegos [Prunus persica (L. Bastch] apresentam reduzida vida útil pós-colheita devido, em parte, a sua alta taxa respiratória e amadurecimento rápido. Estes processos estão relacionados com a produção e a ação do etileno. Pêssegos cv. Aurora-1 foram colhidos em dois estádios de maturação (verde e maduro e tratados com o antagonista competitivo do etileno 1-metilciclopropeno (1-MCP nas concentrações de 0, 100, 300 e 900 nL L-1, durante 12 horas a 25ºC. Após o tratamentos os frutos foram armazenados em condições ambientais (25ºC durante seis dias. Os frutos tratados com 1-MCP apresentaram maior firmeza de polpa e menor perda de coloração de fundo se comparado com os frutos não tratados. O 1-MCP reduziu o desenvolvimento de podridões em frutos do estádio verde, mas não em frutos maduros. O 1-MCP apresenta potencial de aplicação comercial em pêssegos, visando retardar o amadurecimento e aumentar sua vida útil de prateleira.

  18. Characterization and comparison of proteomes of albino sea cucumber Apostichopus japonicus (Selenka) by iTRAQ analysis.

    Science.gov (United States)

    Xia, Chang-ge; Zhang, Dijun; Ma, Chengnv; Zhou, Jun; He, Shan; Su, Xiu-rong

    2016-04-01

    Sea cucumber is a commercially important marine organism in China. Of the different colored varieties sold in China, albino sea cucumber has the greatest appeal among consumers. Identification of factors contributing to albinism in sea cucumber is therefore likely to provide a scientific basis for improving the cultivability of these strains. In this study, two-dimensional liquid chromatography-tandem mass spectrometry coupled with isobaric tags for relative and absolute quantification labeling was used for the first time to quantitatively define the proteome of sea cucumbers and reveal proteomic characteristics unique to albino sea cucumbers. A total of 549 proteins were identified and quantified in albino sea cucumber and the functional annotations of 485 proteins have been exhibited based on COG database. Compared with green sea cucumber, 12 proteins were identified as differentially expressed in the intestine and 16 proteins in the body wall of albino sea cucumber. Among them, 5 proteins were up-regulated in the intestine and 8 proteins were down-regulated in body wall. Gene ontology annotations of these differentially expressed proteins consisted mostly of 'biological process'. The large number of differentially expressed proteins identified here should be highly useful in further elucidating the mechanisms underlying albinism in sea cucumber. PMID:26707782

  19. Toxicological evaluation and oral glucose tolerance test of ethanolic leaf extract of Barleria cristata L. in wistar albino rats

    Directory of Open Access Journals (Sweden)

    R. Narmadha

    2013-12-01

    Conclusion: EtBc was revealed the non-toxic nature used for acute toxicity studies and among various doses of this extract, 400 mg/kg brought an effective hypoglycemic activity in wistar albino rats. [Int J Basic Clin Pharmacol 2013; 2(6.000: 742-746

  20. GARLIC (ALLIUM SATIVUM) EXTRACT AFFECTS THE FREE AMINO ACID LEVEL IN THE GONADS OF FEMALE ALBINO RATS

    OpenAIRE

    Srivastava S; Pathak P. H.

    2012-01-01

    Effect of Allium sativum Linn. (Alliaceae) (Raw Garlic Extract (RGE)) was studied on free amino acids (FAA) level in female albino rats. The garlic extract was tested in three different doses 1ml, 2ml and 4ml/ kg body weight daily as low, medium and high dose respectively for a period of 7, 14, 21 and 28 days. The significant (P

  1. Effects of radiation and maze performance on brain contents of norepinephrine and 5-hydroxytryptamine in male albino rat

    International Nuclear Information System (INIS)

    The objectives of the present study are dealing with the normal patterns of the occurrence of norepinephrine (N E) and 5 - hydroxytryptamine (5-H T) in different brain regions of albino rat and to determine the changes in brain levels of both substances when the rat was subjected to various effects

  2. Estudo quantitativo do nervo frênico de rato albino em função do envelhecimento

    OpenAIRE

    Romeu Rodrigues de Souza; Ii-Sei Watanabe; Gerson Chadi; Maria Vilma de Araújo

    1990-01-01

    The phrenic nerve of albino rats was studied for age changes in number of fibres, myelin sheath thickness and axon calibre. Nerves were excised from three young and three aged rats. There is no significant morphological differences between nerves from young and aged rats and no difference with age was found in the number of fibres, myelin sheath thickness and axon calibre.

  3. CGP 35348, GABAB Receptor Antagonist, Has a Potential to Improve Neuromuscular Coordination and Spatial Learning in Albino Mouse following Neonatal Brain Damage

    Directory of Open Access Journals (Sweden)

    Q. Gillani

    2014-01-01

    Full Text Available To study the effect of CGP 35348 on learning and memory in albino mice following hypoxia ischemia insult, 10 days old albino mice were subjected to right common carotid artery ligation followed by 8% hypoxia for 25 minutes. Following brain damage, mice were fed on normal rodent diet till they were 13 week old. At this time point, mice were divided into two groups. Group 1 received saline and group 2 intrapertoneally CGP 35348 (1 mg/mL solvent/Kg body weight for 12 days. A battery of tests used to assess long term neurofunction (Morris water maze, Rota rod and open field along with brain infarct measurement. Overall CGP 35348 has improved the motor function in male and female albino mice but effects were more pronounced in female albino mice. In open field, CGP 35348 treated female albino mice had demonstrated poor exploratory behavior. During Morris water maze test, gender specific effects were observed as CGP 35348 had improved spatial learning and memory and swimming speed in male albino mice but had no effect in female albino mice following hypoxia ischemia encephalopathy (HIE. We concluded that GABAB receptor antagonists CGP 35348 can be used to improve gender based spatial memory.

  4. Retención y Penetración en Estacones de Eucalyptus Saligna. Sometidos a Tratamiento con CuSO4 y Sal CCC, en Baño Caliente y frio y Vacio-Presión

    Directory of Open Access Journals (Sweden)

    Escobar C. Oscar

    1987-09-01

    Full Text Available Este trabajo describe y da los resultados obtenidos con el pretratamiento de estacones de Eucalyptus saligna a tres soluciones de CUS04 y su posterior tratamiento con sales CCA (OSMOSE K-33. El sulfato de cobre se aplicó por el método de baño caliente y frío, seguido por el proceso de difusión durante una semana; para los anteriores tratamientos se usó madera verde o parcialmente seca al aire; las sales CCA se aplicaron a madera seca por el método de vacío-presión. Una de las razones para llevar a cabo este refuerzo de las sales CCA, es haber encontrado postes de eucalipto severamente atacados por hongos, en especial con pudrición blanda. Los estacones fueron tratados inicialmente con soluciones de sulfato de cobre a 1 %, 2% y 3% de concentración; luego los estacones fueron tratados con una solución de sal CCA al 2.5% de concentración por vacío-presión. Se usaron 40 estacones distribuídos en 4 grupos de 10: tres (3 grupos fueron usados para el tratamiento con las soluciones de CUS04 y solución de CCA; el grupo restante fue tratado con la sal CCA únicamente, el cual fue usado como grupo testigo para fines de comparación en los ensayos de campo (cementerios.

  5. Investigando con personas con dificultades de aprendizaje

    Directory of Open Access Journals (Sweden)

    Borja González Luna

    2013-12-01

    Full Text Available El artículo muestra los orígenes de lo que Walmsley (2008 denomina «investigación inclusiva». Para comprender qué se entiende por investigación inclusiva tenemos que remontarnos a los debates epistemológicos sobre las metodologías cuantitativas y cualitativas, acontecidos en la década de los 90, en torno a la revista Disability & Society. A partir de una síntesis de dichos debates, focalizados en el ámbito de la «discapacidad intelectual y del desarrollo», se exponen dos estrategias de colaboración con dicha población: a una aproximación etnográfica (de trabajo grupal, y b una aproximación biográfica (de trabajo individual. A continuación se esboza un posible diseño de trabajo de campo que intenta superar el paradigma cualitativo «clásico» con el objetivo de incluir a dicho colectivo más allá del rol de «sujetos de la investigación». Para finalizar se recoge el debate sobre la accesibilidad de los resultados de la investigación a los participantes en dichas investigaciones, y con ello la necesaria innovación en el ámbito de las «devoluciones» de los resultados, cuando se trata de incluir a personas que presentan limitaciones para la comprensión del lenguaje abstracto oral y/o escrito.

  6. COMPARISON OF ANTIDEPRESSANT ACTIVITY OF LOSARTAN WITH IMIPRAMINE IN ALBINO MICE

    Directory of Open Access Journals (Sweden)

    Choppadandi

    2016-06-01

    Full Text Available OBJECTIVES Comparison of antidepressant activity of Losartan with Imipramine in albino mice. BACKGROUND Of all the afflictions that trouble the soul, depression is the commonest characterised by a state of low mood and aversion to activity that can affect a person's thoughts, behaviour, feelings and physical well-being. Similarly, hypertension is another condition which has emerged as a major public health problem in India and many other developing countries. There is compulsion that 35% of the population has to use the antihypertensives and antidepressants simultaneously for a long period of time to maintain their health. The present work is aimed at comparing antidepressant activity of losartan with imipramine which acts by raising brain BDNF (Brain derived neurotrophic factor levels so that a single agent can be used for both the conditions avoiding multiple medications. METHOD 18 Albino mice were taken, divided into 6 mice in each group and subjected to Forced swim test. All the drugs were administered orally. Drugs were administered and time of onset of immobility is measured 60 min. after the drug administration along with total duration of immobility. Animals are exposed to pretest of 15 min., 24 hrs. prior to the 6 min. swim test. Each animal is considered immobile when it ceased to struggle and swim and remained floating in the water, only moving to keep its head above water. Control group received distilled water (10 mL/kg. Standard group received Imipramine (5 mg/kg and test group was treated with Losartan (3 mg/kg. The Forced swim test for each mouse was video captured which was later analysed to count the time of onset of immobility and total duration of immobility. RESULTS Data was analysed using Analysis of Variance (ANOVA. Losartan showed significant antidepressant activity indicated by significant delay (P<0.05 in the time of onset of immobility and significant reduction (P<0.05 in the total duration of immobility compared to

  7. Modulatory influence of Aloe vera against radiation and cadmium induced hepatic lesions in Swiss albino mice

    International Nuclear Information System (INIS)

    The major objectives in radiobiology has been the development of agents that can mitigate the damage produced by ionizing radiation to normal tissues and thus reduces the side effects caused by radiation and improvement of cancer radiotherapy. The various agents have drawn attention of researchers as they provide wider acceptability and least side effects. The current study was aimed to investigate the protective effect of Aloe vera against radiation and cadmium induced changes in the liver of Swiss albino mice. For the study healthy male Swiss albino mice (6 to 8 weeks old) were selected from an inbred colony and kept in polypropylene cages. They were provided with standard mice feed and tap water ad libitum. The animals were exposed to 3.0 and 6.0 Gy of gamma radiation with or without cadmium chloride treatment. The animals of experimental groups were administered Aloe vera juice seven days prior to irradiation or cadmium chloride treatment. The animals of each group were autopsied at each post treatment interval of 1, 2, 4, 7, 14 and 28 days of treatment. The various biochemical parameters estimated were total proteins, glycogen, cholesterol, acid and alkaline phosphatase activities, DNA and RNA. After routine procedure, histopathological changes were also observed. The changes in various biochemical parameters were observed in the form of increase of decrease in values. The histopathological changes observed on day-1 after exposure to 3.0 Gy were distortion of hepatic architecture, intracellular oedema, narrower sinusoids, cytoplasmic degranulation, vacuolation and pycnotic nuclei. The changes were more marked on day-4 and continued up to day-14. But on day-28 the sign of recovery was observed. After exposure to a higher dose (6.0 Gy) similar changes were noticed but they were more pronounced and there was late manifestation of recovery. In the combined treatment of radiation and cadmium chloride synergistic effects were observed. The liver of Aloe vera treated

  8. Colombia & the New Global Economy: Implications of Tratado de Libre Comercio for Colombian Industry, Engineers and Engineering Educators

    Directory of Open Access Journals (Sweden)

    Bopaya Bidanda

    2006-11-01

    Full Text Available The landscape of the world economy has changed significantly over the last twenty five years. The inter-connectedness of national economies, the rapid ascent of the BRIC countries (Brazil, Russia, India, China in the global engineering environment and the pro-active role of organizations such as the World Trade Organization, regional alliances such as the EU, and Mercosur are factors that have synergized this movement towards a new order. The completion of the Tratado de Libre Comercio (TLC agreement is a major milestone for the Colombian economy. These developments have serious and opportunistic implications for organizations, engineers, and engineering educators. We focus here on the drivers and consequences for engineering practitioners and educators. Corporate strategies, along with the need for engineering curriculum reform to ensure that Colombian engineers will effectively compete in the global marketplace, are detailed.

  9. Los derechos fundamentales y su incorporación en los tratados de Libre Comercio

    Directory of Open Access Journals (Sweden)

    Carlos Valega Puello

    2004-01-01

    Full Text Available En la última década del siglo XX, noobstanteasistira un proceso de ace/eración de las economías mundiales, caracterizadas por la globalización y el neoliberalismo, han sido importantes los esfuerzos encaminados a proteger los derechos de los trabajadores, especialmente los relacionados con la libertad de asociación y libertad sindical y derecho de negociación colectiva, la eliminación de toda forma de trabajo forzoso y obligatorio, la abolición del trabajo infantil y la eliminación de toda discriminación en materia de empleo y ocupación. Tales esfuerzos ratifican la necesidad de incorporar la dimensión social tanto en los acuerdos comerciales como en los procesos de integración regional.

  10. Tratamiento endovascular de una fuga paraprotésica mitral con dispositivo Amplatzer®

    Directory of Open Access Journals (Sweden)

    Alberto Sciegata

    2012-10-01

    Full Text Available El leak o fuga paraprotésica mitral se presenta entre el 5 y el 17% de los pacientes tratados con cirugía de reemplazo valvular. En general, los defectos son únicos, la mayoría se encuentran localizados en la región postero-medial del anillo valvular y solo la tercera parte produce reflujo de grado grave. El cierre percutáneo por vía endovascular es una alternativa terapéutica válida en pacientes con elevado riesgo para re-operación. La estrategia de abordaje depende de la localización, tamaño, morfología y relaciones adyacentes del o los defectos. El procedimiento debe ser realizado por profesionales con experiencia en el tratamiento de cardiopatías estructurales y en el manejo de estos dispositivos de cierre, y se considera imprescindible la utilización de un ecocardiograma transesofágico tridimensional. Se presenta el caso de un paciente con una fuga paraprotésica valvular mitral que fue cerrada con un dispositivo Amplatzer ® introducido en forma percutánea desde la vena femoral.

  11. Tratamiento con inmunoterapia específica en niños con Rinitis Alérgica y/o Asma Bronquial. Área Norte. 2005 - 2007.

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    Matilde Iraida Morera Franco

    2007-10-01

    Full Text Available Se realizó un estudio descriptivo longitudinal durante el período Enero 2005_ Enero 2007 en el Policlínico Norte del municipio Sancti Spíritus. El universo estuvo constituido por el total de niños con edades de 2_15 años con enfermedades alérgicas, a los que se realizó pruebas de alergia e indicó tratamiento con inmunoterapia específica por vía subcutánea, la muestra estuvo formada por 75 pacientes con asma bronquial, rinitis alérgica y/o ambas enfermedades, con el objetivo de determinar el comportamiento del tratamiento con inmunoterapia específica se aplicó el método porcentual para el análisis de resultados, donde el grupo etáreo que predominó fue de 2 _5 años, más del 65 % de los pacientes tratados refirieron mejoría de los síntomas las causas más frecuentes de abandono de tratamiento fue la aparición de infecciones intercurrentes, no ocurrió reacción anafiláctica en ninguno de los casos estudiados, el tratamiento con inmunoterapia puede reducir el uso de otros tratamientos asociados como Intal, antihistamínicos, broncodilatadores y esteroides.

  12. O-PRECISION: UNA ALTERNATIVA METODOLÓGICA DE TRABAJO CON PERSONAS CON DISCAPACIDAD FÍSICA E INTELECTUAL

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    Victoria Rey Niño

    2015-04-01

    Full Text Available La Clasificación Internacional del Funcionamiento, de la Discapacidad y de la Salud (CIF define la discapacidad como un término genérico que abarca deficiencias, limitaciones de la actividad y restricciones a la participación. En este caso hablamos de personas con discapacidad física e intelectual por parálisis cerebral, lo que significa que su acceso al mundo de la actividad física se encuentra en la mayoría de los casos muy restringido. Pero existe una modalidad de la orientación llamada Orientación de Precisión u O-Trail que, según la Federación Deportiva de Orientación (FEDO, ha sido adaptada para ofrecer a todos, independientemente de su sexo, edad, capacidad o discapacidad física, la oportunidad de participar en igualdad de condiciones en una típica competición de orientación. Como sugiere Arribas y Sánchez (1998: “En la actividad física podemos encontrar recursos y herramientas de intervención adecuadas a cada contexto y etapa de ciclo vital además, a través de su práctica pueden verse satisfechas determinadas necesidades e intereses personales y grupales, que pueden ser tratados desde un planteamiento educativo” . Este proyecto tiene la intención de ir más allá y pretende utilizar la Orientación de precisión como una herramienta para implementar una alternativa metodológica de trabajo a las actividades que se llevan a cabo con un colectivo de personas con discapacidad física e intelectual en la Asociación Cultural y rehabilitadora de Discapacitados Físicos de Palencia, desarrollando y estimulando sus aspectos intelectuales y sociales mediante una disciplina deportiva desconocida para ellos, con la intención de que aumente su motivación por participar.Objetivo: Implementar la O-Precisión como alternativa metodológica de trabajo con personas con discapacidad física e intelectual con el fin de desarrollar sus capacidades cognitivas y aumentar su autoestima.

  13. Harmful effect of protein difficiency on lipids, glucose, insulin and estradiol levels in female albino rats

    International Nuclear Information System (INIS)

    The present study was undertaken to investigate the harmful effect of protein deficient diet on some biochemical activities in serum of female rats. Protein malnutrition is a well known socioeconomic problem in different parts of the world. Many studies were investigated on the biological parameters following protein malnutrition in human and experimental animals. Forty albino female rats were divided into 3 groups. The first group (10 rats) fed 18% protein diet and served as normal control and the other two groups, each contains 15 rats, fed 5% protein for 21 and 45 days, respectively, and served as malnourished groups. The results showed significant decrease in total body weight, serum glucose, insulin and estradiol levels in the third group as well as decrease in the total cholesterol, HDL-cholesterol, LDL-cholesterol and VLDL-cholesterol and triglycerides concentrations that compared to normal control rats

  14. Evaluation of radioprotective effects of Rajgira (Amaranthus paniculatus) Extract in Swiss albino mice

    International Nuclear Information System (INIS)

    The radioprotective efficacy of aqueous extract of Rajgira (Amaranthus paniculatus) leaves against whole body gamma radiation was studied in Swiss albino mice. The oral administration of Rajgira extract at 800 mg/kg body weight/day for 15 consecutive days before whole body exposure to radiation was found to be effective with the LD50/30 values of 6.33 and 8.62 Gy for irradiation alone and Rajgira+irradiation group, respectively, giving a dose reduction factor of 1.36. This effect of Rajgira accompanied the increased endogenous spleen colonies and the spleen weight without any side effect or toxicity, as well as the modulation of the radiation-induced decrease of reduced glutathione and the radiation-induced increase in lipid peroxidation assessed in the liver and the blood. (author)

  15. Correction of glutathione metabolism in the liver of albino rats affected by low radiation doses

    International Nuclear Information System (INIS)

    The levels of total glutathione GSH, GSSG and the activities of glutathione reductase and glutathione peroxidase were studied in the liver of adult albino rats subjected to 3-fold external γ-irradiation throughout 2 weeks at the overall dose of 0.75 Gy after 15 h, 2 and 5 days from the last irradiation. Some animals were injected intraperitoneally with the pantothenate containing complex > 3 times on days 1-3 before the irradiation. The radiation related decrease of GSH, GSH/GSSG and the total glutathione level was prevented by the prophylactic administration of the complex and probably at the expense of the activation of the G-SH biosynthesis and/or transport in the liver by the CoA biosynthetic precursor. (author)

  16. Spermatotoxic, cytotoxic and genotoxic evaluation of aqueous extract of Ocimum gratissimum in albino mice

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    Akeem Akinboro

    2013-11-01

    Full Text Available Ocimum gratissimum (Lamiaceae is an alternative medicine as well as food condiment in African and Asian countries. Information on its safe consumption is important considering its wide utilization. The potential effects of aqueous extract of this plant on cell division, chromosome structure and sperm morphology in mice were investigated. The Inductions of chromosomal aberrations and abnormal sperm cells were not dose dependent. However, these were and sperm morphology tests, respectively. Aberrant sperm cell in form of tail folded over head was observed most. These observations suggest possible mutagenic activity of the aqueous extract of O. gratissimum in albino mice. Key words: Ocimum gratissimum, chromosome, mitotic index, sperm cells, aqueous extract  

  17. HYPOGLYCEMIC ACTIVITY OF PASSIFLORA EDULIS SIMS LEAF EXTRACT IN WISTAR ALBINO RATS

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    Kanakasabapathi Devaki

    2011-09-01

    Full Text Available The traditional medicinal plant P.edulis was tested for its hypoglycemic effect in Wistar albino rats. The oral glucose tolerance test was performed in overnight fasted normal as well as in alloxan induced diabetic rats (150 mg/kg, of alloxan, i.p. with the administration of 100,200,300,400 mg/kg of b.wt of P.edulis. The blood sample withdrawn at 0, 60, 120, 180 min of glucose administration from the retro orbital sinus by capillary puncture indicated the hypoglycemic nature of the P.edulis leaf extract and identified the most effective dose as 200mg/kg b.wt.

  18. Macroscopic description of the coronary arteries in Swiss albino mice (Mus musculus

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    A. Yoldas

    2010-05-01

    Full Text Available A total of 25 (13 male, 12 female adult, healthy Swiss albino mice were used to investigate the origin, course and anastomoses of coronary arteries. Coloured latex was injected into the aortic arch to enable these arteries to be clearly discerned. A. coronaria sinistra was larger than A. coronaria dextra. It was divided into a Ramus interventricularis paraconalis and a Ramus circumflexus sinister. However, in 2 specimens, the septal ramus, was observed to stem directly from the left coronary artery, and only 1 ventricular branch arose from the left circumflex. The collateral branches of the paraconal interventricular ramus had a larger diameter and more extensive distribution was observed in these specimens. The A. coronaria dextra was divided into a Ramus septalis and Ramus circumflexus dexter. The Ramus interventricularis subsinuosis was not detected in this study. The ventricular branches of the left coronary artery run intramyocardially whereas the branches of the right coronary artery course subendocardially.

  19. Sub-chronic toxicity and heavy metal toxicity study on Kappaphycus alvarezii in albino rats

    Institute of Scientific and Technical Information of China (English)

    AbiramiRG; KowsalyaS

    2012-01-01

    Objective: This study aimed to evaluate the toxicity of Kappaphycus alvarezii methanolic extracts in albino rats. Methods: Sub-chronic toxicity was tested with a single dose of intraperitonal administration of the extract as per the OECD guidelines in the experimental group rats and the control group rats was fed with standard diet and water ad libitum. Mortality, behaviour changes, clinical signs and symptoms, food intake, body weight and any abnormalities of the visceral organs were observed. Results: The results revealed that the algal extract resulted in neither mortality nor any abnormalities. The Most of the serum biochemical parameters and hematological values were similar in control and experimental groups, histopathological examination of the vital organs like liver, kidney, spleen, brain and heart revealed no obvious abnormality in the control group and Kappaphycus alvarezii treated group. Conclusion: It may be concluded that Kappaphycus alvarezii rich in nutrient and nutraceutial potentials and also safety food for human consumption.

  20. Haematological And Biochemical Changes Induced By Amaranth Impact On Male Albino Rats

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    Shadia Ali Radwan; Ahmed Riad El-Sayed; Mohammed Salah Al-Shinnawy

    2010-09-01

    Full Text Available The present investigation was performed to study the effect of daily administration (interperitoneal injection of synthetic coloring agent amaranth at dose 50 mg /kg b.w. /day for two periods (7 and 21 days, using male albino rats. The effects of amaranth on growth, haematological and some biochemical parameters were examined throughout the study. The results revealed that amaranth treatment cause a marked change in treated groups when compared with control. They showed a significant decrease in percentage of body weight change, RBCs count, Hb concentration and HCT value, while, they recorded a significant increase in WBCs, serum activity of AST and ALP, in addition to serum urea and creatinine levels in treated rats. But ALT and bilirubin showed insignificant changes throughout the experiment.

  1. Prevention of radiation-induced hepatic damage in Swiss albino mice by Aloe vera leaf extract

    International Nuclear Information System (INIS)

    The radioprotective effect of the Aloe vera leaf extract was studied in Swiss albino mice against radiation-induced changes in the liver. The mice were treated with 1000 mg/kg of body weight orally, once a day for 15 consecutive days, before exposure to a single dose of gamma radiation (6 Gy), half an hour after the last administration. The irradiation of mice caused a significant elevation in lipid peroxidation followed by a decrease in glutathione, acid phosphatase and alkaline phosphatase. The treatment of mice before irradiation elevated the glutathione, acid phosphatase and alkaline phosphatase, and was accompanied by a decline in lipid peroxidation. Recovery and regeneration from radiation damage were faster in pretreated animals than the animals in the irradiation-only group. The data clearly indicate that the Aloe vera leaf extract significantly reduced the deleterious effects of radiation on the liver and it could be a useful agent in reducing the side effects of therapeutic radiation. (author)

  2. Aloe vera gel provides protection to Swiss albino mice against radiation induced injury

    International Nuclear Information System (INIS)

    Aloe gel powder was administered orally to Swiss albino mice at the dose of 250, 500 and 750 mg/kg body weight/day for 15 consecutive days with and without irradiation with 8 Gy to find out its maximum effective radioprotective dose. 30 days survivality and change in levels of lipid peroxidation (LPO), reduced glutathione (GSH) and vitamin C were studied at 1 hour and 30 days for this purpose. In Aloe treated (750 mg/kg b. wt.) 8 Gy irradiated animals 30 days survivality, contents of GSH and vitamin C were higher and LPO level was lesser at 1 hour and 30 days in comparison to those treated with Aloe at the dose of 250 and 500 mg/kg body weight and irradiated with 8 Gy. These results indicate that Aloe administration at the dose of 750 mg/kg body weight was found to be the most effective

  3. Effect of Escherichia coli infection on the histopathology of albino mice visceral organs

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    Abin Biswas

    2010-03-01

    Full Text Available Histopathology is very essential in assessing the nature and state of the tissues. It is used widely to examine the visceral organs in various diseases, infections and disorders. It provides the required insight and details about the possible malfunctioning of the disease or infection. Albino mice were taken and test group was infected withEscherichia coli. The control group was not infected with any linical pathogen. The histopathological examination was carried out to determine the effect of infection in the test group. Liver, spleen and kidney were the visceral organs which were used for the study. The size, shape and other morphological characteristics had markeddifference in case of infected mice when compared with control group mice. Histopathological analysis can be further extended in the case of other clinical pathogenic infections which could lead to nteresting results.

  4. Effect of Aqueous Flower Extract of Catharanthus roseus on Alloxan Induced Diabetes in Male Albino Rats

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    A. Natarajan

    2012-04-01

    Full Text Available Catharanthus roseus is widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus. The present study was carried out to investigate the antidiabetic and hyperlipidemic potential of Catharanthus roseus on alloxan induced diabetes in male albino rats. Oral administration of aqueous extract of Catharanthus roseus at a dose of 250 mg, 350 mg, and 450 mg/kg body weight for 30 days to diabetic rats resulted in significant reduction in blood glucose, reduction in lipid profile and also prevented a decrease in body weight. Histological observation demonstrated significant fatty changes and inflammatory cell infiltrates in pancreas of diabetic rats. But, supplementation with Catharanthus roseus to diabetic rats significantly reduced the fatty changes and inflammatory cell infiltrates.

  5. Effect of salvia Egyptiaca extract on cholinergic system in adult male albino rats

    International Nuclear Information System (INIS)

    The daily oral administrations of Salvia aegyptiaca extract, equivalent to 2 g/kg body weight for 4 weeks, caused significant decrease in acetylcholine esterase activity in whole blood and in all tested brain areas (cerebellum, pons + medulla oblongata, striatum, cerebral cortex, hypothalamus, midbrain and hippocampus) of male albino rat nearly all over the experimental period. Treatment with Salvia aegyptiaca extract also resulted in significant increase in acetylcholine content in the cerebral cortex and hippocampus' nearly throughout the whole experimental period. It could be concluded from the present results that the extract of Salvia aegyptiaca caused an increase in acetylcholine content and this increase may be due to the decrease in the activity of acetylcholine esterase enzyme which play an important role in the treatment of Alzheimer's disease

  6. Histopathological changes in Wistar albino rats exposed to aqueous extract of unripe Carica papaya

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    Taofeeq Oduola

    2010-05-01

    Full Text Available Background: Exposure of animals to xenobiotics may or may not trigger adverse response at cellular levels. Aqueous extract of unripe Carica papaya is consumed by sickle cell patients as antisickling agent in Western Nigeria. Aim: This study was undertaken to investigate the effects of Carica papaya on certain organs in Wister albino rats exposed to aqueous extract of unripe Carica papaya. Materials and Methods: Different doses of aqueous extract of unripe Carica papaya were administered orally daily for 42 days to six groups of rats. At the end of exposure, the animals were sacrificed and tissue sections were prepared from livers, kidneys, hearts and small intestines using standard techniques. Results: Histopathological results showed that no pathological changes were observed in tissue sections of experimental animals when compared with tissue sections of the same organs in control animals. Conclusion: No pathological changes were elicited in the organs of rats exposed to aqueous extract of unripe Carica papaya.

  7. Histopathological changes in Wistar albino rats exposed to aqueous extract of unripe Carica papaya

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    Taofeeq Oduola

    2010-01-01

    Full Text Available Background : Exposure of animals to xenobiotics may or may not trigger adverse response at cellular levels. Aqueous extract of unripe Carica papaya is consumed by sickle cell patients as antisickling agent in Western Nigeria. Aim : This study was undertaken to investigate the effects of Carica papaya on certain organs in Wister albino rats exposed to aqueous extract of unripe Carica papaya. Materials and Methods : Different doses of aqueous extract of unripe Carica papaya were administered orally daily for 42 days to six groups of rats. At the end of exposure, the animals were sacrificed and tissue sections were prepared from livers, kidneys, hearts and small intestines using standard techniques. Results : Histopathological results showed that no pathological changes were observed in tissue sections of experimental animals when compared with tissue sections of the same organs in control animals. Conclusion : No pathological changes were elicited in the organs of rats exposed to aqueous extract of unripe Carica papaya.

  8. Effect of internal radiation 131-I on leucocyte and erythrocyte of albino wistar mice

    International Nuclear Information System (INIS)

    The hemopoiesis tissues is one of the most radiosensitive tissue in the body. The aim of this investigation is to know the effects of short period internal radiation 131-I on erithrocyte and leucocyte female albino Wistar mice. Two groups of adult female Wistar mice were used in this investigation. In the first group each mice was treated per oral with Na-131-I having radioactivity aqual to 2.05 mCi. No treatment was applied in the second group which was use as control. Five replication were used. The blood samples were collected from the tail in every 7 days up till 35 days after the treatment. Number of blood cells was counted according to Neubauer count chamber method. It was significantly found that the leucocyte increased and the erithrocyte decreased in the treated group. It seemed that recovery accured 21 days after the treatment. (author). 20 refs, 2 figs, 2 tabs

  9. Some Neuro hormonal Effects of ruta chalepensis in adult male albino rats

    International Nuclear Information System (INIS)

    Oral sub-chronic administrations of Ruta chalepensis extract equivalent to 3.0 g/kg body weight were given to male albino rats daily for four weeks (0.5 ml solution/100 g/ rat). The data revealed significant increases in tyrosine, dopamine (DA) and norepinephrine (NE) in all tested brain areas throughout most of the experimental intervals. Significant increases of serum leutinizing hormone (LH) and testosterone were also observed while serum prolactin was decreased significantly. It could be also concluded from the present results that treatment with Ruta chalepensis extract significantly increased catecholamine content. This observation may be in part due to an increase in its synthesis through an increase of the peripheral availability of tyrosine for brain synthesis of catecholamine and/or a decrease in its release

  10. Effect of cow urine on wound healing property in Wister Albino Rats

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    V.P. Tikare.,Paniraj K.L and Swetha R

    Full Text Available The wound healing activity of cow urine was studied in Wistar albino rats. The efficacy of wound healing property was evaluated by excision wound model. The parameter studied was the rate of wound contraction. The studies on excision wound healing revealed that all the groups showed decreased wound area from day to day. On day 4th, the external application of urine showed significant increase in wound healing in male and female rats compared to all other groups. However, on 14th post wounding day, Group I and VIII animals showed 0 % and 0.40.4 % of healing was left, which may be due to normal immunity of the animals. Where as nitrofurazone treated animals showed 0 % and 0.50.3 % healing .The study revealed that the cow urine on external application to the wound, hastened the wound healing process. [Vet. World 2011; 4(7.000: 317-321

  11. Inheritance of a new albino mutation in Brazilian free-range black chickens

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    W Jorge

    2008-09-01

    Full Text Available A genetically recessive albino mutation, which inhibits pigment development in the eyes, skin, and feathers of domestic chickens from Brazil, is described. This mutation appeared in a flock of completely black chickens of a private breeder. There are no information on the origin, breed, or specific line of the birds. Pigment inhibition is apparently complete in the feathers and eyes. Bird sight is very impaired, but no histological examination was carried out. Ratios obtained in F2 and backcrossed birds indicate that a single autosomal recessive gene is responsible for the condition. The data suggest that the absence of melanin in the eyes, skin, and feathers (symbol cc is a mutation of the pigmented C wild gene.

  12. An albino armored catfish Schizolecis guntheri (Siluriformes: Loricariidae from an Atlantic Forest coastal basin

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    Marcelo F. G. de Brito

    2005-03-01

    Full Text Available We report here on an albino specimen of Schizolecis guntheri caught in the rio Bonito in the rio Macaé basin, Rio de Janeiro State, southeastern Brazil. The hypothesis that albinism is more common in fishes with cryptobiotic and/or nocturnal habits is strengthened by additional records of this chromatic anomaly.Relatamos aqui o albinismo em um espécime de Schizolecis guntheri capturado no rio Bonito na bacia do rio Macaé, estado do Rio de Janeiro. A hipótese do albinismo ser mais comum em peixes com hábitos criptobióticos e/ou noturnos é fortalecida por registros adicionais desta anomalia cromática.

  13. The Role Of Melatonin In Aluminium Induced Genotoxicity In Female Albino Rats

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    Zeinab E. Hanafy

    2007-09-01

    Full Text Available Aim of the work, In spite of the wide range of use of aluminium. With the increasing awareness of possible health hazards associated with their use, more attention have been focused on their biological and biochemical activity. Aluminium salts are used as the active antiperspirant in under cosmetics, but the effects of widespread, long term and increasing use remain unknown. Aluminium is known to have genotoxic profile, capable of causing both DNA alterations and epigenetic effects. Melatonin reduces the free radical generation and metal detoxification .This study was planned to determine the effects of melatonin on aluminium induced toxicity in the chromosomes of bone marrow cell . Material and Methods ,Forty female albino rats were used in the present work for the chromosomal analysis. Four groups of adult female albino rats were used in the following way: Group -I, control group; Group-II,50 mg /kg b.wt aluminium orally; Group-III, 50g / kg b.wt melatonin orally and Group- IV, 50 mg /kg b.wt aluminium orally (am +50 g / kg b.wt melatonin orally(pm. Doses were given 30 days. All animals were sacrificed and the bone marrow of femur bones was taken for subsequent cytogenetic studies. The results, Aluminium treatment induced a significant increase in the structural as well as numerical chromosomal aberrations . The frequency of chromosomal aberrations showed significant decrease when rats treated with melatonin and aluminium .In conclusion, the results indicated that melatonin showed a significant improvement of genetic damages induced by aluminium

  14. EVALUATION OF ANXIOLYTIC POTENTIAL OF ETHANOLIC EXTRACT HYPERICUM HOOKERIANUM IN STRESS INDUCED SWISS ALBINO MICE

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    S.Subakanmani

    2012-04-01

    Full Text Available The aim of the present work is evaluate to Anxiolytic profile of Hypericum hookerianum in stress induced Swiss albino mice. The study was carried out using Swiss albino mice (25- 30 g. The Anxiolytic effect of aerial parts of ethanolic extract of Hypericum hookerianum was evaluated by using behavioral analysis like Elevated plus maze (EPM test, Open Field Test (OFT, Hole Board Test (HBT, Light dark exploration Test (LDE in restraint stress induced animals. Behavioral test parameters for anxiety were assessed followed by biochemical parameters (lipid per oxidation, super oxide dismutase, catalase, glutathione per oxidase, reduced glutathione, etc. and Diazepam 1 mg/kg served as a standard Anxiolytic drug, administered intraperitonealy. The results were shown that, ethanolic extract of H.hookerianum (Hh 100mg/kg and Hh 200 mg/kg, p.o. significantly increased the percentage of time spent and number of entries in open arm in EPM. In LDE, the extract produced significant increase in time spent, number of crossing and decrease in the duration of immobility in light box. In OFT, the extract showed significant increase in number of rearings, assisted rearings and number of square crossed, all of which are demonstrations of exploratory behavior. Biochemical analyses revealed an increase in lipid per oxidation, depletion of super oxide dismutase, reduced glutathione, catalase activity and glutathione per oxidase in stress induced animals as compared to unstressed animal. Six days treatment of Hh (100 mg/kg, 200 mg/kg comparable with Diazepam, significantly attenuated restraint stress-induced behavioral and oxidative damage. The results of the present study suggest that an ethanolic extract of H.hookerianum may possess Anxiolytic activity in stressed animals and provide a scientific evidence for its traditional claim.

  15. 6-gingerol ameliorates gentamicin induced renal cortex oxidative stress and apoptosis in adult male albino rats.

    Science.gov (United States)

    Hegazy, Ahmed M S; Mosaed, Mohammed M; Elshafey, Saad H; Bayomy, Naglaa A

    2016-06-01

    Ginger or Zingiber officinale which is used in traditional medicine has been found to possess antioxidant effect that can control the generation of free radicals. Free radicals are the causes of renal cell degeneration that leads to renal failure in case of gentamicin induced toxicity. This study was done to evaluate the possible protective effects of 6-gingerol as natural antioxidant on gentamicin-induced renal cortical oxidative stress and apoptosis in adult male albino rats. Forty adult male albino rats were used in this study and were randomly divided into four groups, control group; 6-gingerol treated group; gentamicin treated group and protected group (given simultaneous 6-gingerol and gentamicin). At the end of the study, blood samples were drawn for biochemical study. Kidney sections were processed for histological, and immunohistochemical examination for caspase-3 to detect apoptosis and anti heat shock protein 47 (HSP47) to detect oxidative damage. Gentamicin treated rats revealed a highly significant increase in renal function tests, tubular dilatation with marked vacuolar degeneration and desquamation of cells, interstitial hemorrhage and cellular infiltration. Immunohistochemically, gentamicin treated rats showed a strong positive immunoreaction for caspase-3 and anti heat shock protein 47 (HSP47). Protected rats showed more or less normal biochemical, histological, and immunohistochemical pictures. In conclusion, co-administration of 6-gingerol during gentamicin 'therapy' has a significant reno-protective effect in a rat model of gentamicin-induced renal damage. It is recommended that administration of ginger with gentamicin might be beneficial in men who receive gentamicin to treat infections. PMID:27036327

  16. Effect of sorafenib on sperm count and sperm motility in male Swiss albino mice

    Science.gov (United States)

    Shetty, Surekha Devadasa; Bairy, Laxminarayana Kurady

    2015-01-01

    The issue of male germ line mutagenesis and the effects on developmental defects in the next generation has become increasingly high profile over recent years. Mutagenic substance affects germinal cells in the testis. Since the cells are undergoing different phases of cell division and maturation, it is an ideal system to study the effect of chemotherapeutic agents. There are lacunae in the literature on the effect of sorafenib on gonadal function. With background, a study was planned to evaluate the effects of sorafenib on sperm count and sperm motility in male Swiss albino mice. Male Swiss albino mice were used for the study. The animals were segregated into control, positive control (PC) and three treatment groups. PC received oral imatinib (100 mg/kg body weight) and treatment groups received 25, 50, and 100 mg/kg body weight of sorafenib orally for 7 consecutive days at intervals of 24 h between two administrations. The control group remained in the home cage for an equal duration of time to match their corresponding treatment groups. The animals were sacrificed at the end of 1st, 2nd, 4th, 5th, 7th, and 10th weeks after the last exposure to drug, respectively. Sperm suspensions were prepared and introduced into a counting chamber. Total sperm count and motility were recorded. There was a significant decrease in sperm count and sperm motility by sorafenib which was comparable with the effect of PC imatinib. Sorafenib adversely affects sperm count and sperm motility which are reversible after discontinuation of treatment. PMID:26605157

  17. Using the Tg(nrd:egfp/albino zebrafish line to characterize in vivo expression of neurod.

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    Jennifer L Thomas

    Full Text Available In this study, we used a newly-created transgenic zebrafish, Tg(nrd:egfp/albino, to further characterize the expression of neurod in the developing and adult retina and to determine neurod expression during adult photoreceptor regeneration. We also provide observations regarding the expression of neurod in a variety of other tissues. In this line, EGFP is found in cells of the developing and adult retina, pineal gland, cerebellum, olfactory bulbs, midbrain, hindbrain, neural tube, lateral line, inner ear, pancreas, gut, and fin. Using immunohistochemistry and in situ hybridization, we compare the expression of the nrd:egfp transgene to that of endogenous neurod and to known retinal cell types. Consistent with previous data based on in situ hybridizations, we show that during retinal development, the nrd:egfp transgene is not expressed in proliferating retinal neuroepithelium, and is expressed in a subset of retinal neurons. In contrast to previous studies, nrd:egfp is gradually re-expressed in all rod photoreceptors. During photoreceptor regeneration in adult zebrafish, in situ hybridization reveals that neurod is not expressed in Müller glial-derived neuronal progenitors, but is expressed in photoreceptor progenitors as they migrate to the outer nuclear layer and differentiate into new rod photoreceptors. During photoreceptor regeneration, expression of the nrd:egfp matches that of neurod. We conclude that Tg(nrd:egfp/albino is a good representation of endogenous neurod expression, is a useful tool to visualize neurod expression in a variety of tissues and will aid investigating the fundamental processes that govern photoreceptor regeneration in adults.

  18. Effect of Bougainvillea spectabilis Leaves on Serum Lipids in Albino Rats Fed with High Fat Diet

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    H. Saikia

    2011-04-01

    Full Text Available Dyslipidemia is major problem among population those have sedentary life style as well as in diabetics. Bougainvillea spectabilis is most commonly found in India as an ornamental plant and has got anti-diabetic action due to presence of one insulin mimicking agent D-pinitol (3-O-methyl-chiroinositol. The present investigation was undertaken to evaluate the effect of alcoholic extract of leaves of Bougainvillea spectabilis (AEBSL on serum lipid profile in albino rats fed with high fat diet (HFD and to compare it with a standard hypolipidaemic drug simvastatin. Thirty healthy albino rats of both sexes (100-200 g were randomized into 5 groups of 6 animals each. The groups were treated as follows: Group A: normal diet (ND; Group B: HFD (vanaspati ghee + coconut oil mixture in ratio of 3:2 at 10 ml/kg/day; Group C: HFD+ AEBSL (100 mg/kg/day; Group D: HFD + AEBSL (200 mg/kg/day; Group E: HFD + simvastatin (1.8 mg/kg/day. Lipid profile was estimated after 8 weeks of treatment. AEBSL showed a significant (p<0.01 reduction in total cholesterol (TC, Triglyceride (TG, Low density lipoprotein (LDL, Very low density lipoprotein (VLDL levels and significant (p<0.01 increase in high density lipoproteins (HDL in hypercholesteromic rats (Group C and Group D. AEBSL 200 mg/kg/day found to be more effective than AEBSL 100 mg/kg/day. There is also significant improvement in atherogenic index (p<0.01 and increases the percentage of protection AEBSL treated animals. Alcoholic extract of leaves of Bougainvillea spectabilis leaves have excellent lipid lowering potentiality.

  19. ANALGESIC ACTIVITY OF AQUEOUS EXTRACT OF CURCUMA AMADA (MANGO - GINGER IN MALE ALBINO WISTAR RATS

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    Kumari Bai

    2015-09-01

    Full Text Available BACKGROUND: Mango ginger ( Curcuma amada Roxb. has morphological resemblance with ginger, but imparts mango flavour. According to Ayurveda and Unani medicinal systems , the biological activities include antioxidant, antibacterial, antifungal, anti - inflammatory, antiallergic, CNS depressant and analgesic activity. Hence curcuma amada aqueous extract for analgesic activity was evaluated in pain animal models. Pain is a most common complaint of many medical conditions, and pain control is one of t he most important therapeutic priorities. Curcuma Amada suppresses the inflammatory mediators associated with pain. However there is no scientific data suggestive of its analgesic activity. Hence this study was carried out to evaluate its role in central a nd peripheral models of pain. OBJECTIVE: To Evaluate rhizomes of Curcuma Amada for analgesic activity in male albino wistar rats . MATERIALS AND METHODS: Albino rats, the proven models for analgesic studies. They were obtained from the animal house of DR.B. R. Ambedkar Medical College. Animals were maintained as per CPCSEA guidelines . The aqueous extract of curcuma amada was used.4x2 groups of 6 Rats were used to ensure that results obtained were statistically significant using ANOVA test. Analgesic activity was assessed with the help of following screening methods . Acetic Acid Writhing Method using Acetic Acid . Tail Flick Method using the Analgesiometer . Tail Immersion Method using Hot Water (55 0 C . Hot Plate method using Hot Plate . RESULT S: Aqueous extract of curcuma amada significantly suppressed the 1% acetic acid induced writhing response in rats when compared to control group (Gum acacia. In Tail flick test and Hot plate test Curcuma Amada increases the latency period of pain (reaction time. In Tail im mersion test the test drug significantly (P < 0.001 reduces pain at 30 min when compared to control group at 60 min of oral administration. CONCLUSION : The present findings indicate that

  20. ANTIDIABETIC AND HYPOLIPIDEMIC ACTIVITY OF GYMNEMA SYLVESTRE IN DEXAMETHASONE INDUCED INSULIN RESISTANCE IN ALBINO RATS

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    Hemanth Kumar V, Nagendra Nayak IM , Shobha V Huilgol, Saeed M Yendigeri , Narendar K

    2015-07-01

    Full Text Available Background: Gymnema sylvestre plant was widely used for medicinal purpose. The plant leaves were traditionally used to treat diabetes. Aim: To determine the antidiabetic and hypolipidemic activity of Gymnema sylvestre in dexamethasone induced insulin resistance in Albino rats. Objectives: The present study was undertaken to evaluate antidiabetic and hypolipidemic activity of Gymnema sylvestre leaf aqueous extract against dexamethasone induced insulin resistance in Albino rats. Materials and Methods: Animals were divided into five groups. Normal control and diabetic control group received gum acacia (2% orally for 12days, and normal saline (i.p., dexamethasone (8mg/kg/i.p. from day 7- day12 respectively. Two test groups (Gymnema sylvestre leaf aqueous extract 2 and 4gm/kg/p.o./12days and standard control received metformin (2gm/kg/p.o./12 days. The two test groups, standard control group received dexamethasone (8mg/kg/i.p from day 7- day 12 respectively. The antidiabetic and hypolipidemic activity was estimated by measuring serum glucose, insulin, lipid levels and histopathological evaluation of liver tissue. Results were analyzed by using one way ANOVA followed by Scheffe’s multiple comparison test. Results: Treatment with aqueous extract of Gymnema sylvestre (2 and 4gm/kg/p.o significantly (p<0.01 altered the elevated glucose, lipid, insulin levels and also improved the histopathology of liver in dexamethasone induced insulin resistance rats. Conclusion: Treatment with aqueous extract of Gymnema sylvestre improved the altered glucose, insulin and lipid profile in insulin resistance rats.

  1. Effect of Stem Cell Therapy on Induced Diabetic Keratopathy in Albino Rat

    Science.gov (United States)

    Zickri, Maha Baligh; Ahmad, Nagwa Abdel Wahab; Maadawi, Zeinab Mohamad El; Mohamady, Yasmin Kamal; Metwally, Hala Gabr

    2012-01-01

    Background and Objectives: Type 2 diabetes mellitus (DM) is a prevalent disorder. Diabetic keratopathy is a well-known ocular complication secondary to type 2 DM. Topical insulin application did not affect apoptosis and necrosis levels in corneal epithelium. Autologous cell transplantation is not a viable option for diabetic patients with bilateral limbal stem cell deficiency. The present study aimed at assessing the possible effect of hemopoeitic stem cell (HSC) therapy on induced diabetic keratopathy in albino rat. Methods and Results: Fifteen male albino rats were divided into control group of 2 rats, diabetic group of 8 rats receiving single intraperitoneal (IP) injection of 50 mg/kg streptozotocin (STZ). 3 animals were sacrificed 6 weeks following confirmation of diabetes to confirm keratopathy and 5 rats were sacrificed 4 weeks following confirmation of keratopathy. SC therapy group included 5 rats injected with HSCs 6 weeks following confirmation of diabetes and sacrificed 4 weeks following SC therapy. Cord blood collection, stem cells isolation and labeling were performed. Eye specimens were subjected to histological, histochemical, immunohistochemical, morphometric and statistical studies. In diabetic group, the central cornea showed multiple cells with vacuolated cytoplasm and dark nuclei, focal epithelial discontinuity, reduced corneal thickness and less number of layers of corneal and conjunctival epithelia. In stem cell therapy group, few cells with vacuolated cytoplasm and dark nuclei were found in the corneal and conjunctival epithelia with more number of epithelial layers. Conclusions: A definite ameliorating effect of HSC therapy was detected on diabetic keratopathy. The therapeutic cells were effective in limiting corneal epithelial changes. PMID:24298355

  2. Modification Of Cesium Toxicity By Prussian Blue In Adult Male Albino Rats

    International Nuclear Information System (INIS)

    The purposes of this study were to asses the toxicological effects of stable cesium chloride, and investigate the possible therapeutic role of Prussian blue (PB) in adult male albino rats.Thirty two adult male albino rats were used in this study and classified to 4 groups (8 rats/group) as follows:1- Group one (G1): rats were considered as controls and kept on the commercial diet without any treatments.2-Group two (G2): treated with daily oral cesium chloride (50 mg/300 g body weight).3-Group three (G3): treated with daily oral Prussian blue (250 mg/rats).4-Group four (G4): treated with cesium chloride at a daily oral dose of 50 mg/300 g body weight + Prussian blue at a daily oral dose of 250 mg/rats.All animals were administered the CsCl and/or PB via intubation tube and the duration of this study was 35 consecutive days. Hemoglobin (Hb), hematocrit (Ht%), red blood cells (RBC), white blood cells (WBC), folic acid, vitamin B12, total protein, albumin, globulin, A/G ratio, ALT, AST, total bilirubin, alkaline phosphatase, blood glucose, urea, creatinine, creatine phosphokinase (CPK), lactate dehydrogenase (LDH), sodium, potassium, calcium and inorganic phosphorous and body weight were determined in all groups.The data obtained revealed that the intake of stable cesium chloride in adult male rats caused significant decreases in the Hb, hematocrit, folic acid, vitamin B12 and potassium contents, with significant increases in WBC count, urea and creatinine levels and no effect on the other parameters. On the other hand, PB as a therapeutic agent caused significant amelioration in the changes produced by CsCl with variable degrees leading to the conclusion that the therapeutic agents might provide a protection against the toxicological effects of CsCl.

  3. Nigella sativa oil Ameliorates ionizing Radiation induced cellular injury in Male Albino Rats

    International Nuclear Information System (INIS)

    Nigella sativa (NS), commonly known as black seed, is a plant spices in which thymoquinone is the main active ingredient isolated from the black seeds. The seeds of Nigella sativa are used in herbal medicine all over the world for the treatment and prevention of a number of diseases. The aim of this study was focused on investigating the possible protective effect of NS against gamma radiation induced nephrotoxicity and inflammatory changes in male albino rats. Twenty four albino rats were divided into four equal groups as follows: control group, irradiated group (animals subjected to whole body gamma irradiation at a dose of 6 Gy), treated group (rats treated with 0.2 ml/kg, i.p., NS oil for 4 weeks), and treated irradiated group (animals treated with 0.2 mL/kg, i.p., NS oil for 4 weeks then exposed to whole body gamma irradiation at a dose of 6 Gy). The obtained results revealed that the administration of Nigella sativa oil to irradiated rats significantly ameliorated the changes induced in kidney antioxidant system; catalase and glutathione peroxidase activities as well as reduced glutathione concentration. Also, NS oil restored the kidney function indices (urea and creatinine) near normal level when compared with their equivalent values in irradiated rats. In addition, the changes in serum tumor necrosis factor alpha (TNF-α), Interleukin-1β (IL-1β) and Interleukin-6 (IL-6) activities were markedly improved compared to the corresponding values of irradiated group. The histopathological results showed distinctive pattern of ischemic renal injury in irradiated group, while in treated- irradiated group the renal tissues showed relatively well-preserved architecture with or without focal degeneration. In conclusion, NS acts in the kidney as a potent scavenger of free radicals to prevent or ameliorates the toxic effects of gamma irradiation as shown in the biochemical and histopathological study and also NS oil might provide substantial protection against

  4. Prevention of radiation and cadmium induced haematological alternations in the Swiss albino mice by Aloe Vera

    International Nuclear Information System (INIS)

    The development of effective radio protectors and radio recovery drugs is of great importance in view of their potential application during both planned (i.e., radiotherapy) and unplanned radiation exposure (i.e., in the nuclear industry and natural background radiation). The combined effect of radiation and cadmium further increases the causation of damages to organs and tissues. Aloe vera has enjoyed a reputation as a healer for millennia, based primarily on anecdotal evidence. For the last 40 years concerted efforts by the scientific research community has brought Aloe vera out of the realm of folk medicine, providing it solid medical and scientific foundation. Haematopoietic organs are among the most radiosensitive cells in the living organisms. Therefore, present study was carried out to study the modulatory influence of Aloe vera against radiation and cadmium induced hematological changes in the Swiss albino mice. For the study, six to eight weeks old male Swiss albino mice were procured and kept in polypropylene cages.The animals were exposed 3.5 Gy and 7.0 Gy of gamma radiation with or without cadmium chloride treatment. The Aloe vera was administered seven days prior to irradiation or cadmium chloride treatment. Five animals from each group were autopsied by cervical dislocation at each post treatment interval of 1, 2, 4, 7, 14 and 28 days. Blood was collected in heparinized tubes to estimate various haematological parameters viz. RBC, WBC, PCV, Haemoglobin and MCV. Radiation exposure resulted in a significant decline in RBC, WBC, PCV, Haemoglobin and MCV up to day-14 in peripheral blood, thereafter it increased up to day-28 without reaching to normal. After combined treatment of radiation and cadmium chloride the more severe changes were noticed showing synergistic or additive effect. An early and fast recovery was seen in Aloe vera pretreatment groups. Thus, it may be concluded from above observation that Aloe vera has the potential of combating the

  5. EFFECT OF FLUORIDE ON KIDNEY OF ALBINO RABBIT-AN EXPERIMENTAL STUDY

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    Santosh K.

    2014-08-01

    Full Text Available BACKGROUND: Fluoride is present in environment in various forms and ingested by man from solid foods, drinks, drinking water and inhaled from the air. Out of these, fluoride is present in large quantities in dissolved state in many sources of drinking water producing toxicity in man. Fluoride, being excreted mainly through the kidneys, seems to damage it causing renal dysfunction. Kidneys are among the most sensitive body organs in their histopathological and functional responses to excessive amounts of fluoride. Trace elements are essential and beneficial to human being in minute concentrations. However, intake in large quantities produces adverse and toxic effects on our body. OBJECTIVE: The present study was designed to investigate the toxic effects (evaluated as histopathological changes of sodium fluoride on the kidney in albino rabbit. MATERIALS AND METHODS: Total 40 albino rabbits were used for this study, among them 8 rabbits were taken in the control group (Group A and16 rabbits each were taken in both group B and group C who were administered low and high dose of fluoride respectively. After 2 weeks interval, up to 16 weeks the histology of the kidney of each group of the rabbit was studied for histological analysis. RESULT: Histological changes in the kidneys of both Group B and Group C rabbits, following continuous daily exposure to sodium fluoride solutions in two different doses (0.5% solution for Group B and 3% solution for Group C for different durations of time were studied in detail and compared with those of the controls (Group A. CONCLUSION: It is concluded that Sodium Fluoride solution in high doses for prolonged period has a definite adverse effect on the renal parenchyma.

  6. Los derechos de los inversores extranjeros sobre la tierra según los tratados de protección de inversiones: una visión desde Latinoamérica

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    Nicolás M. Perrone

    2016-01-01

    Full Text Available En los últimos diez años, la inversión extranjera en agricultura se ha incrementado notablemente en Latinoamérica. Inversores extranjeros tanto privados como estatales están interesados en la producción agrícola, ya sea por el beneficio esperado o para asegurarse el abastecimiento de alimentos. Este aumento de la inversión puede ser positivo para los países de la región. No obstante, para realizar esta determinación, es necesario comprender, entre otros, los efectos legales de estos flujos de inversión. Este trabajo sostiene que los derechos de propiedad que adquieren los inversores extranjeros sobre la tierra y los emprendimientos agrícolas pueden ser diferentes de los derechos de los inversores nacionales Esto se debe a los tratados para la protección de inversión extranjera. El fortalecimiento de los derechos de los inversores extranjeros afecta la relación de estos inversores con los Estados receptores. Este artículo analiza los efectos de los derechos de los inversores extranjeros en relación con cinco categorías de iniciativas estatales. Concretamente, 1 el derecho a exportar la producción o al precio de exportación frente a medidas comerciales y tributarias; 2 el derecho a continuar el proyecto frente a cambios dentro del paradigma regulatorio;3 el derecho a continuar el proyecto frente a cambios de política o nuevas preferencias sociales; 4 el derecho a recibir una compensación mayor frente a reformas agrarias o programas de reparación histórica;5 el derecho a mantener su plan de negocios frente a una crisis alimentaria.

  7. Hematoma após raquianestesia tratado conservadoramente: relato de caso e revisão da literatura Hematoma después de raquianestesia tratado conservadoramente: relato de caso y revisión de la literatura Conservative treatment of hematoma after spinal anesthesia: case report and literature review

    Directory of Open Access Journals (Sweden)

    Daniel Segabinazzi

    2007-04-01

    objetivo de este trabajo fue describir un caso de hematoma después raquianestesia tratado de forma conservadora y revisar los trabajos en la literatura. RELATO DEL CASO: Paciente del sexo masculino, 73 años, 65 kg, 1,67 m, estado físico ASA III. Fue sometido a raquianestesia para retirada de catéter de diálisis peritoneal. Durante la realización de la punción hubo parestesias en el miembro inferior derecho. Se inyectaron 15 mg de bupivacaína hiperbárica a 0,5% sin vasoconstrictor. Veinte y cuatro horas después de la realización del bloqueo el paciente permanecía con anestesia en silla de montar y con dolor lumbar, y 48 horas después del procedimiento presentó una incontinencia urinaria. La resonancia nuclear magnética demostró la existencia de un proceso expansivo subaracnoideo, con compresión de raíces nerviosas (L4 a S1. Después de la evaluación del neurocirujano, se empieza el tratamiento conservador. El paciente recibió alta hospitalaria el 18° día de postoperatorio asintomático. CONCLUSIÓN: El caso presentado mostró una buena evolución con el tratamiento conservador.BACKGROUND AND OBJECTIVES: Spinal anesthesia caries the risk of bleeding. Compression of nervous tissue secondary to the formation of a hematoma can cause neurological damage, which, if not diagnosed and treated in a timely fashion, can be permanent. The identification of risk factors, diagnosis, and early treatment are important for the prognosis. The objective of this report was to describe the case of a hematoma after spinal anesthesia treated conservatively, and review the literature. CASE REPORT: Male patient, 73 years old, 65 kg, 1.67 m, and ASA physical status III, underwent spinal anesthesia for removal of a peritoneal dialysis catheter. During the puncture, the patient experienced paresthesia of the right lower limb. Fifteen milligrams of 0.5% hyperbaric bupivacaine without vasoconstrictor were administered. Twenty-four hours later, saddle anesthesia and lumbar pain

  8. Estabilidad de emulsiones preparadas con proteínas de sueros de soja

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    Jorge Wagner

    2011-12-01

    Full Text Available Por precipitación con acetona en frio, se obtuvieron muestras de proteínas aisladas de dos sueros de soja, el suero SS proveniente de la obtención de aislados de soja y el suero de tofu ST. A partir del SS y del mismo suero previamente liofilizado y calentado (SSLC se obtuvieron las proteínas denominadas PSS y PSSLC, respectivamente; a partir de ST se preparó la muestra PST. El objetivo del trabajo fue analizar la estabilidad de emulsiones o/w preparadas con las proteínas de sueros de soja en forma comparativa con un aislado de soja nativo (ASN. Las emulsiones se prepararon por homogeneización de dispersiones proteicas (0,1–1,0 % p/v en buffer fosfato 10 mM pH 7 y aceite de girasol (Φmásico=0,33, empleando un Ultraturrax T-25. La estabilidad fue evaluada por medida del aceite separado, distribución de tamaño de partículas (por difracción láser y los grados de cremado y coalescencia evaluados a través de perfiles de BackScattering. Se observó que en todas las concentraciones ensayadas las emulsiones preparadas con proteínas aisladas (por precipitación con acetona en frío de suero de tofu tratado térmicamente (PST tenían una estabilidad comparable a la de emulsiones preparadas con ASN. Se halló una estabilidad menor en emulsiones con proteínas nativas de suero de soja (PSS obtenido en laboratorio no tratado térmicamente. Las proteínas obtenidas de este suero liofilizado y calentado (PSSLC exhibieron una mejor capacidad emulsionante. Los resultados mostraron que las proteínas de sueros de soja presentan buenas propiedades emulsionantes y estabilizantes dependientes del grado de desnaturalización y glicosilación alcanzado.

  9. en pacientes con obesidad

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    Alcia María Alvarado Sánchez

    2005-01-01

    Full Text Available El objetivo de este estudio fue evaluar la eficacia de una intervención psicológica en pacientes con obesidad. Se utilizó un diseño cuasiexperimental con un grupo de estudio y un grupo control. Después de la intervención, se encontró una diferencia significativa en la reducción de peso entre los grupos. Asimismo, hubo un incremento significativo en la autoestima del grupo estudiado.

  10. Funcionando con la computadora

    OpenAIRE

    Álvarez, Eduardo; Astiz, Mercedes; Medina, Perla; Montero, Y.; Oliver, María; Rocerau, M. Cristina; Valdez, Guillermo; Vecino, María; Vilanova, Silvia

    2004-01-01

    En este trabajo se presenta la descripción y resultados de la segunda etapa de una experiencia planteada con el objetivo de indagar la manera en que los alumnos determinan e interpretan funciones que explican situaciones problemáticas valiéndose de una nueva forma de trabajo en el aula: la utilización de la computadora como herramienta y un programa asistente matemático. La primera etapa consistió en el desarrollo de un taller optativo con alumnos de entre 14 y 15 años de edad del Colegio Dr....

  11. Note on breeding and parental care behaviours of albino Hoary-bellied Squirrel Callosciurus pygerythrus (Rodentia: Sciuridae in Sibsagar District of Assam, India

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    G. Kalita

    2009-06-01

    Full Text Available A few individuals of albino Horay-bellied Squirrels along with normal gray individuals of Callosciurus pygerythrus have been observed in Sibsagar district of Assam, India. One albino female was studied in captivity. This paper presents our observations on the breeding behaviour and the parental care exhibited by the albino squirrel in captivity. The squirrel bred twice in captivity with a normal male of the same species. In both the periods, a single male baby with normal coat colour developed. Oral dose of vitamin E has been found helpful in the breeding of the studied squirrel species. The mother squirrel exhibited parental care by carrying her baby using her mouth, to a safer place during danger. However, the observed phenomenon is unlike that of the cat species. Some of the habitat ecology and feeding habits of the albino squirrels have also been studied, both in natural and in captive conditions.

  12. La elevación del seno maxilar en el tratamiento con implantes dentales: un estudio a 4 años

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    A. Jiménez Guerra

    2015-12-01

    Full Text Available Introducción: El objetivo del presente estudio era mostrar los resultados de la elevación del seno maxilar con biomateriales en el tratamiento con implantes del maxilar posterior. Métodos: 70 pacientes edéntulos parciales fueron tratados con 181 implantes Galimplant® con superficie arenada y grabada con ácidos para la rehabilitación del maxilar posterior mediante la técnica de elevación de seno y relleno con betafosfato tricálcico (Osteoblast®. Los implantes fueron cargados después de un periodo de cicatrización de 6-8 meses. Resultados: Los hallazgos clínicos indican una supervivencia y éxito de los implantes del 98,4%. Tres implantes se perdieron durante el periodo de cicatrización. El 85,1% de los implantes fueron insertados simultáneamente a la elevación del seno maxilar. Después de un periodo medio de carga funcional de 57,4 meses, no ha habido complicaciones tardías. El 22,4% de los implantes fueron restaurados con coronas unitarias y el 77,6% con puentes fijos. Conclusiones: Este estudio indica que la rehabilitación del maxilar posterior con implantes mediante la técnica de elevación del seno maxilar constituye un tratamiento dental exitoso.

  13. Protective effect of Tribulus terrestris L. fruit aqueous extracton lipid profile and oxidative stress in isoproterenol induced myocardial necrosis in male albino Wistar rats

    OpenAIRE

    Sailaja, K.V.; Shivaranjani, V. Leela; Poornima, H.; Rahamathulla, S.B.Md.; Devi, K. Lakshmi

    2013-01-01

    The objective of the present study was to evaluate the possible protective effects of Tribulus terrestris fruit aqueous extract (TTFAEt) on lipid profile and oxidative stress in isoproterenol (ISO) induced myocardial necrosis in albino Wistar rats. Albino Wistar rats were divided into normal control, TTFAEt alone treated, ISO control and pretreated (TTFAEt+ISO) groups. The extract was administered at a dose of 50 mg/kg body weight for 40 days orally by gavage and ISO was administered at a dos...

  14. Protective effect of Tribulus terrestris L. fruit aqueous extract on lipid profile and oxidative stress in isoproterenol induced myocardial necrosis in male albino Wistar rats

    OpenAIRE

    K. Lakshmi Devi; Poornima, H.; Rahamathulla, S.B.Md.; Sailaja, K.V.; Shivaranjani, V. Leela

    2013-01-01

    The objective of the present study was to evaluate the possible protective effects of Tribulus terrestris fruit aqueous extract (TTFAEt) on lipid profile and oxidative stress in isoproterenol (ISO) induced myocardial necrosis in albino Wistar rats. Albino Wistar rats were divided into normal control, TTFAEt alone treated, ISO control and pretreated (TTFAEt+ISO) groups. The extract was administered at a dose of 50 mg/kg body weight for 40 days orally by gavage and ISO was administered at...

  15. Differential effects of alprazolam and clonazepam on the immune system and blood vessels of non-stressed and stressed adult male albino rats

    OpenAIRE

    Elmesallamy, Ghada E.; Abass, Marwa A.; Ahmed Refat, Nahla A.G.; Atta, Amal H.

    2011-01-01

    Benzodiazepines belongs to one of the most commonly used anxiolytic and anticonvulsant drugs in the world. Full description of toxic effects on different organs is lacking for nearly all the current benzodiazepines. The aim of the current work was to study the immunologic and vascular changes induced by sub-chronic administration of alprazolam and clonazepam in non-stressed and stressed adult male albino rats. Forty-two adult male albino rats were divided into 6 groups (I): (Ia) Negative cont...

  16. Evaluation of cardioprotective effect of aqueous extract of Garcinia indica Linn. fruit rinds on isoprenaline-induced myocardial injury in Wistar albino rats

    OpenAIRE

    Patel, Kaksha J.; Ashwin K. Panchasara; Manish J Barvaliya; Purohit, Bhargav M.; Seema N Baxi; Vadgama, Vishal K.; Tripathi, C.B.

    2015-01-01

    In the present study, cardioprotective effect of aqueous extract of Garcinia indica Linn. fruit rinds in isoprenaline-induced myocardial infarction in Wistar albino rats was evaluated. In vitro total phenolic, total flavonoid content and 2, 2’-diphenyl-1-picrylhydrazyl hydrate radical scavenging activity was measured. In vivo effect of aqueous extract of G. indica was evaluated in Wistar albino rats by isoprenaline-induced myocardial injury model. Thirty six rats were randomly divided in 6 gr...

  17. Biosíntesis de dextranos de alto peso molecular mediante la inoculación con Leuconostoc Mesenteroides, var. Mesenteroides (atcc 10830 de jugos residuales de la agroindustria de la piña: síntesis y caracterización de hierro-dextranos

    Directory of Open Access Journals (Sweden)

    José Roberto Vega Baudrit

    2013-01-01

    Full Text Available En este trabajo se muestran los estudios realizados para obtener dextranos a partir de desechos de la agroindustria de piña. La fermentación se llevó a cabo en un biorreactor (10 L, se inoculó con un cultivo de Leuconostoc mesenteroides, var. mesenteroides (ATCC 10830. Se centrifugó y se precipitó y purificó con etanol. Fue caracterizado por medio de viscosidad, peso molecular y grupos funcionales por espectroscopía infrarroja. Este dextrano fue tratado con el fin de obtener hierro-dextranos.

  18. Estudio del comportamiento del pH en filetes de pejerrey de laguna (Odonthestes bonariensis), conservados con y sin vacío, utilizando distintos tratamientos y almacenados a temperaturas de 4,0 y -1.5º C

    OpenAIRE

    Copes, Julio; Pellicer, K.; Hoyo, G. del; Brocardo, S.; Giannuzzi, Leda

    2008-01-01

    En la industria pesquera, la medición del pH es una variable que reviste gran importancia al momento de juzgar la frescura de los productos derivados de la pesca. El objetivo de este trabajo fue estudiar el comportamiento del pH a partir de filetes de pejerrey de laguna (Odonthestes bonariensis), conservados con y sin vacío, tratados con agua clorada y agua clorada con ácidos cítrico y ascórbico, almacenadas a 4, 0 y -1.5 °C. Se obtuvieron diferencias significativas entre los filetes de pejer...

  19. Efectividad de la sulfadiazina de plata en reepitelización de heridas por quemaduras con líquidos calientes en zonas neutras en niños Effectiveness of silver sulfadiazine in reepithelization of hot liquid burns affecting neutral zones in children

    OpenAIRE

    FRESIA SOLÍS F; LILIANA CORTÉS P; ROLANDO SAAVEDRA O; CLAUDIA RAMÍREZ C

    2007-01-01

    Introducción: Tratamiento de quemaduras con sulfadiazina de plata, sigue siendo de uso frecuente en muchos centros. Objetivo: Determinar el tiempo de re-epitelización clínica en niños con quemaduras por líquidos calientes, tratados con sulfadiazina de plata, su variación según sexo, edad, zona neutra (tórax-abdomen, extremidades sin compromiso articular) extensión, presencia de infecciones, adherencia de aposito y derivación a rehabilitación. Metodología: Revisión retrospectiva de 263 fichas ...

  20. Evaluación de las técnicas de cepillado de bass y vertical en un grupo de pacientes en tratamiento de ortodoncia con técnica mbt

    OpenAIRE

    Yelitza Ivone Baracaldo Ortíz; Fredy Alexander Cabuya Cabuya; Rubén Darío Hurtado Rozo; Edwin Emil Ricaurte Vila; Diana Constanza Gamboa Martínez; Liliana Carolina Báez Quintero

    2012-01-01

    Objetivo: Evaluar la efectividad de las técnicas de Cepillado de Bass y Vertical en pacientes con aparatología ortodóntica fija tratados con la técnica MBT. Materiales y métodos: se realizó un estudio experimental “In vivo” aleatorizado doble ciego; la muestra fue de 100 personas distribuidas en dos grupos, a cada uno se le asignó una Técnica de Cepillado y se dieron instrucciones de higiene oral por medio de charlas personalizadas y por escrito. Se usó el índice de Sillnes y Löe para medir e...

  1. Efecto terapéutico de la dieta macrobiótica Ma-Pi 2 en 25 adultos con diabetes mellitus tipo 2 Therapeutical effect of Ma-Pi2 macrobiotic diet on adults with type 2 diabetes mellitus

    OpenAIRE

    Carmen Porrata Maury; Alfredo Abuín Landín; Abraham Morales Zayas; Raúl Vilá Dacosta-Calheiros; Manuel Hernández Triana; Jorge Menéndez Hernández; María Elena Díaz Sánchez; Mayelín Mirabal Sosa; Concepción Campa Huergo; Mario Pianesi

    2007-01-01

    Se realizó un ensayo clínico, durante 6 meses, en 25 adultos con diabetes mellitus tipo 2, tratados con antihiperglicemiantes, para estudiar el efecto terapéutico de la dieta macrobiótica vegetariana Ma-Pi 2. Se evaluaron datos de encuesta dietética, evolución clínica, estado nutricional, indicadores bioquímicos de rutina y del metabolismo glucídico y lipídico, consumo de medicamentos y eventos adversos. La dieta tuvo presencia mayoritaria de cereales integrales, verduras y hortalizas, legumi...

  2. fertilizada con diferentes abonos

    Directory of Open Access Journals (Sweden)

    Jorge Alberto Elizondo-Salazar

    2007-01-01

    Full Text Available Producción y calidad de la biomasa de morera (Morus alba fertilizada con diferentes abonos. Se llevó a cabo un experimento en la Estación Experimental “Alfredo Volio Mata” de la Universidad de Costa Rica con el fi n de evaluar la aplicación de 150 kg de N/ha/año proveniente de dos abonos orgánicos: lombriabono y compostaje; y de un fertilizante químico, sobre la producción y calidad de la biomasa de morera. El periodo experimental comprendió un ciclo de 12 meses, iniciando en julio del 2003 y fi nalizando en julio del 2004. Se utilizó una plantación de morera de 12 años de establecida con una densidad de siembra de 27.777 plantas/ ha. Se empleó un diseño de bloques completos al azar con cuatro tratamientos: dos abonos orgánicos, nitrato de amonio (33,5% N y un control. Las plantas se podaron a 0,6 m sobre el nivel del suelo al inicio del ensayo. Durante el periodo experimental, las plantas fueron podadas consecutivamente cada 90 días. Las hojas y los tallos fueron separados y analizados para determinar el contenido de materia seca y proteína cruda. La producción de materia seca fue 23% superior y el contenido de proteína cruda fue signifi cativamente mayor con el nitrógeno químico, mientras que el contenido de materia seca fue menor. No se encontraron diferencias signifi cativas entre el tratamiento control y los tratamientos orgánicos.

  3. Qualidade pós-colheita de quivi 'Hayward' tratado com 1-MCP e armazenado sob diferentes atmosferas

    Directory of Open Access Journals (Sweden)

    Marcelo José Vieira

    2012-06-01

    Full Text Available Este trabalho teve por objetivo avaliar o efeito do 1-MCP sobre o amadurecimento e a qualidade pós-colheita de quivi 'Hayward' armazenado sob diferentes atmosferas. Foram conduzidos dois experimentos, com frutos colhidos em pomar comercial localizado em Fraiburgo-SC. No experimento 1, os frutos foram tratados com três doses de 1-MCP (0,0; 0,5 ou 1,0 µL L-1 e armazenados sob atmosfera controlada (AC, contendo 2,0kPa de O2 + 4,5kPa de CO2, a 0ºC ± 0,5ºC, 92 ± 3% UR, e com <40 ηL L-1 de etileno no ambiente, durante 90 e 120 dias, mais sete dias de vida de prateleira a 23ºC. No experimento 2, os frutos foram tratados com 0,0 ou 0,7 µL L-1 de 1-MCP e armazenados sob atmosfera ambiente (AA, contendo 21 kPa de O2 + 0,03 kPa de CO2, a 0 ± 0,5ºC, 90 ± 3% UR, e com 200 a 250 ηL L-1 de etileno no ambiente, durante 30, 60, 90 e 120 dias, mais um e sete dias de vida de prateleira a 23ºC ou AC (contendo 2,0 kPa de O2 + 4,5 kPa de CO2, a 0ºC ± 0,5ºC, 92 ± 3% UR, e com <40 ηL L-1 de etileno no ambiente, durante 60, 90, 120 e 150 dias, mais um e sete dias de vida de prateleira a 23ºC. Os benefícios do tratamento com 1-MCP sobre a conservação da qualidade foram observados tanto para frutos armazenados sob AA quanto sob AC. No experimento 1, não houve diferença entre as doses de 1-MCP de 0,5 e 1,0 µL L-1 sobre o controle do amadurecimento e manutenção da qualidade dos frutos armazenados em AC. No experimento 2, o tratamento com 1-MCP retardou o aumento na taxa de produção de etileno após remoção de câmara fria. A redução da taxa de produção de etileno nos frutos tratados com 1-MCP foi associada ao aumento na conservação da firmeza da polpa sob AC e AA, e redução na incidência de pericarpo translúcido sob AA. O potencial de armazenamento foi aumentado pelo tratamento com 1-MCP em aproximadamente 60 e 30 dias, nos frutos armazenados sob AA e AC, respectivamente.

  4. Características in vivo del epitelio corneal versus magnitud del defecto refractivo, posterior a tratamiento con láser de excímeros

    Directory of Open Access Journals (Sweden)

    Eduardo Rojas Álvarez

    2013-08-01

    Full Text Available Objetivo: describir las características in vivo del epitelio corneal y su relación con la magnitud del defecto refractivo tratado posterior al tratamiento quirúrgico de LASIK. Método: estudio descriptivo, prospectivo-longitudinal con 24 pacientes (48 ojos con astigmatismo miópico intervenidos con el ESIRIS (Schwind-Alemania por la técnica quirúrgica LASIK con microquerátomo pendular. Se analizaron los resultados a partir de técnicas de estadística descriptiva. Se utilizó el microscopio confocal ConfoScan 4 de NIDEK para la obtención y estudio de las imágenes in vivo de tejido corneal. Resultados: el grosor epitelial central medio en el preoperatorio fue 34,7 mm, a los 7 días del posoperatorio hubo un incremento del 36 % en pacientes con defectos refractivos inferiores a 4D y un incremento del 44 % en pacientes con defectos refractivos de 4 D o más. El promedio de densidad de células del epitelio basal a los 7 días fue de 5 098,3±1 654 células/mm², tuvo variaciones mínimas inferiores a la unidad porcentual durante la etapa de estudio. Conclusiones: existió incremento del grosor epitelial posterior a LASIK que fue superior en defectos refractivos mayores de 4 dioptrías. La densidad celular del epitelio basal no tuvo variaciones significativas y fue independiente a la magnitud del defecto refractivo tratado.

  5. Variations in the villus cell population of intestine in the irradiated Swiss albino mouse with and without herbal treatment

    International Nuclear Information System (INIS)

    Generally, the effects of radiations are hazardous, even in moderate doses. The damage caused by radiation is influenced by the relative radiosensitivity of the tissue. Damage to gastrointestinal tract leads to death of the animals 10 to 15 days after radiation exposure to the lethal dose. When Swiss albino mice were irradiated with 6 and 8 Gy of gamma radiation, it caused cytological, pathological and biochemical changes in the gastrointestinal tract. There was a significant decrease in the total cell population (TCP), whereas pyknotic nuclei (PN) and necrotic cells (NC) showed significant increase after irradiation. Pretreatment with Centella asiatica (CA) resulted in a significantly lesser decrease in TCP, whereas, PN and NC showed significant decrease from respective irradiated controls at each autopsy day. It was observed that CA pretreatment provides protection against radiation induced damage in the intestinal mucosa of Swiss albino mice. (author)

  6. Perfil eletrocardiográfico e conteúdo glicogênico muscular de ratos tratados com nandrolona

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    Carlos Alberto da Silva

    2010-12-01

    Full Text Available FUNDAMENTO: Considerou-se o uso indiscriminado de esteroides tanto por atletas de elite quanto por praticantes de atividades físicas. OBJETIVO: Avaliar os efeitos do decanoato de nandrolona sobre o perfil eletrocardiográfico, conteúdo glicogênico e de proteínas totais dos músculos cardíacos e esqueléticos, bem como as concentrações plasmática de albumina. MÉTODOS: Os animais do grupo tratado receberam a droga na concentração 5 mg/kg pela via subcutânea, duas vezes por semana, durante três semanas. Uma vez por semana, os ratos foram anestesiados com Pentobarbital sódico (50 mg/kg, ip e submetidos à avaliação por meio do eletrocardiograma (ECG. Após o período experimental, amostras dos músculos cardíaco (ventrículo esquerdo - VE, sóleo (S, gastrocnêmio branco (GB, gastrocnêmio vermelho (GV, peitoral (P, intercostal (IC e diafragma (D foram prontamente coletadas e analisadas. Os dados (média ± epm foram avaliados de acordo com ANOVA, segundo teste de Tukey (p>0,05. RESULTADOS: Os ratos do grupo tratado apresentaram alterações nos seguintes parâmetros cardíacos: intervalo QRS, intervalo QTc e frequência cardíaca, caracterizados por um aumento desses, tendo o ápice no intervalo da semana de pré-tratamento para a primeira semana. As reservas de glicogênio no VE apresentaram aumento de 127%. Em relação à quantidade de proteínas totais, a diferença significativa foi constatada no S, GV e D. Quanto ao perfil bioquímico e ao hematócrito, foi observado um aumento na porcentagem de eritrócitos. CONCLUSÃO: O estudo mostra que importantes alterações cardíacas são deflagradas precocemente, sugerindo uma hierarquia na sequência de modificações que comprometem a homeostasia do organismo.

  7. Fracturas de clavícula. Tratamiento quirúrgico con clavos intramedulares flexibles

    Directory of Open Access Journals (Sweden)

    Roberto Joaquín Del Gordo D'amato

    2014-05-01

    Full Text Available Se realizó un estudio de tipo descriptivo en una serie de casos en el cual se presentan los resultados de 12 fracturas de clavícula tratadas en forma quirúrgica mediante clavos intramedulares flexibles. Todos los pacientes fueron tratados por los autores en la Clínica El Prado del D.T.C.H. de la Ciudad de Santa Marta mediante reducción cerrada bajo control radioscópico. Presentando resultados excelentes y buenos en todos los casos. Así mismo, se evidenció consolidación clínica a las cuatro semanas con reintegro a la vida laboral alrededor de las seis semanas. Todos los pacientes mostraron alto grado de satisfacción con el resultado obtenido. Se concluye que el tratamiento empleado es una alternativa terapéutica a tener en cuenta en aquellas fracturas desplazadas, sean estas del tercio externo, medio o interno que permite consolidación sin las complicaciones que con alguna frecuencia se presentan con el tratamiento conservador. (Duazary 2006; 2:115-120

  8. Evaluacion de las alteraciones conductuales y dopaminergicas en ratones con bajas concentraciones de plomo.

    Directory of Open Access Journals (Sweden)

    N. Martínez Riera

    2001-01-01

    Full Text Available La investigación de los efectos del plomo en animales de experimentación y sus consecuencias en el desarrollo neurológico conductual es compleja y controvertida. Conociendo que la maduración neurológica de los ratones ha culminado en edades que oscilan entre los 25-35 días, nuestro objetivo ha sido investigar si la administración de soluciones de diferentes concentraciones de plomo, durante tiempos establecidos de acuerdo a las dosis-ingesta, producía alteraciones en los juegos solitarios en animales de experimentación adultos. Se trabajó con ratones adultos de ambos sexos de la cepa C3H, alimentados con dieta estándar y agua ad libitum. Se utilizaron seis lotes: tres experimentales que fueron tratados con acetato de plomo en el agua de bebida en diferentes concentraciones: 1, 1000 y 2000 ppm y en los tres grupos controles, la ingesta fue de agua potable. En este trabajo se estudiaron los juegos solitarios de los animales: 1 Actividad locomotora, 2 Aseo total, 3 Exploración subterránea (en tiempo y frecuencia y 4 Exploración aérea total. Se determinó el nivel de dopamina presente en el cerebro de los mismos por espectrofluorometría. Los resultados obtenidos de las alteraciones conductuales en los animales de experimentación analizados con tests no paramétricos fueron: disminución significativa de la actividad locomotora (número de cuadros, de la exploración subterránea (en tiempo, de la exploración aérea (en tiempo y del aseo total, no observándose variaciones significativas en la exploración subterránea (en frecuencia. Las variables investigadas estarían mediadas por distintos sistemas de neurotrasmisión. En la dopamina determinada en cerebro de ratones con ingesta de plomo de 1 - 1000 - 2000 ppm se encontró disminución significativa de la misma en los ratones tratados con respecto a los grupos controles.

  9. Effects of Calendula Essential Oil-Based Cream on Biochemical Parameters of Skin of Albino Rats against Ultraviolet B Radiation

    OpenAIRE

    Mishra, Arun K.; Mishra, Amrita; Verma, Anurag; Chattopadhyay, Pronobesh

    2012-01-01

    Reactive oxygen species (ROS) generated from UV-B radiation have the capacity to cause oxidative decomposition which leads to the formation of toxic components as well as lipid peroxidation. Considering this fact, the present study was performed to evaluate the effect of a cream (O/W) containing the essential oil of Calendula officinalis on biochemical parameters of the skin of albino rats against UV-B radiation. The fingerprint analysis of Calendula essential oil was performed by HPLC with s...

  10. Evaluation of genotoxic potential of Hypericum triquetrifolium extract in somatic and germ cells of male albino mice

    OpenAIRE

    Bushra M. A. Mohammed,; Sarbast K. Q. Kheravii

    2011-01-01

    Hypericum triquetrifolium aqueous extract were studied for the first time for its toxic and the possible clastogenic effects in vivo on the bone marrow and spermatozoa cells of Swiss albino mice. The lethal dose of the aqueous extract was considered to be 10.33 g/kg of the body weight, injected subcutaneously. The doses which were chosen for treatments were 2, 1, and 0.25 g/kg. H. triquetrifolium extract induce statistically significant increases in the average...

  11. Evaluation of anti-depressant and anxiolytic activity of Rasayana Ghana Tablet (A compound Ayurvedic formulation) in albino mice

    OpenAIRE

    Deole, Yogesh S.; Chavan, Sulakshan S.; Ashok, B. K.; Ravishankar, B.; Thakar, A.B.; Chandola, H. M.

    2011-01-01

    In recent years, many Ayurvedic formulations are being researched to provide an effective antidepressant and anxiolytic drug in the field of psycho-pharmacology. The present study was planned to evaluate the anti-depressant and anxiolytic activity of Rasayana Ghana Tablet comprising three herbs Guduchi (Tinospora cordifolia Miers), Aamalaki (Emblica officinalis Garten) (RGT) and Gokshura (Tribulus terrestris Linn). Swiss albino mice were divided into four groups of six animals each, comprisin...

  12. Effect of aqueous extract of Tinospora cordifolia on functions of peritoneal macrophages isolated from CCl4 intoxicated male albino mice

    OpenAIRE

    Sharma Gauri D; Sengupta Mahuya; Chakraborty Biswajit

    2011-01-01

    Abstract Background The current practice of ingesting phytochemicals for supporting the immune system or fighting infections is based on centuries-old tradition. Macrophages are involved at all the stages of an immune response. The present study focuses on the immunostimulant properties of Tinospora cordifolia extract that are exerted on circulating macrophages isolated from CCl4 (0.5 ml/kg body weight) intoxicated male albino mice. Methods Apart from damaging the liver system, carbon tetrach...

  13. ASSESSMENT OF LOCAL ANESTHETIC ACTIVITY OF LIGNOCAINE BY SIMULTANEOUS ADMINISTRATION OF POTASSIUM CHANNEL AGONISTS NICORANDIL IN ALBINO RATS

    OpenAIRE

    Lakkol Kiran J; Umakant Patil N; Kallappa Shivashankaramurthy G; VinodKumar C.S

    2013-01-01

    There are reports about a possible weak local anaesthetic activity of nicorandil, a potassium channel agonist (PCA). In addition, modification of local anesthetic activity of lignocaine by PCA is not clearly defined. The objective of the present study is to evaluate local anesthetic activity of nicorandil and to evaluate the influence of nicorandil on the efficacy and duration of local anesthesia by lignocaine. A total number of 84 albino rats of either sex were divided into 14 groups of 6 an...

  14. Trichosanthes dioica root extract induces tumor proliferation and attenuation of antioxidant system in albino mice bearing Ehrlich ascites carcinoma

    OpenAIRE

    Bhattacharya, Sanjib; Haldar, Pallab Kanti

    2011-01-01

    Trichosanthes dioica Roxb. (Cucurbitaceae), called pointed gourd in English, is a dioecious climber grown widely in the Indian subcontinent. The present study assessed the influence of treatment of hydroalcoholic extract of Trichosanthes dioica root (TDA) on Ehrlich ascites carcinoma (EAC) in Swiss albino mice with effects on antioxidant systems. Twenty-four hours after intraperitoneal inoculation of tumor (EAC) cells in mice, TDA was administered at 25 and 50 mg/kg for 8 consecutive days. On...

  15. Effect of fruit extract of Fragaria vesca L. on experimentally induced inflammatory bowel disease in albino rats

    OpenAIRE

    Lalit Kanodia; Mondita Borgohain; Swranamoni Das

    2011-01-01

    Aim : Ulcerative colitis and Crohn′s disease are chronic recurrent inflammatory bowel disease (IBD) of unknown origin. Oxidative stress is believed to be a key factor in the pathogenesis and perpetuation of the mucosal damage in IBD. Materials and Methods : Ethanolic extract of Fragaria vesca (EFFV) fruits was prepared by percolation method and subjected to oral toxicity testing using OECD guidelines. Albino rats were pretreated orally for 5 days with 3% gum acacia in control, EFFV 500 mg...

  16. Garlic (Allium sativum) Extract Supplementation Alters the Glycogen Deposition in Liver and Protein Metabolism in Gonads of Female Albino Rats

    OpenAIRE

    Sashank Srivastava; P. H. Pathak

    2012-01-01

    Garlic is an ayurvedic herb that has been extensively used as medication and as the taste enhancer of the food. The present investigation was undertaken to provide data on the efficacy of garlic (Allium sativum Linn.) extract on glycogen deposition and protein metabolism in female albino rats that may further explore medicinal potential of garlic. The rats were divided into four groups A, B, C and D, keeping group A as a healthy control. The garlic extract was tried in three different doses, ...

  17. Estudo quantitativo do nervo frênico de rato albino em função do envelhecimento

    Directory of Open Access Journals (Sweden)

    Romeu Rodrigues de Souza

    1990-01-01

    Full Text Available The phrenic nerve of albino rats was studied for age changes in number of fibres, myelin sheath thickness and axon calibre. Nerves were excised from three young and three aged rats. There is no significant morphological differences between nerves from young and aged rats and no difference with age was found in the number of fibres, myelin sheath thickness and axon calibre.

  18. Effect of saffron (Crocus sativus L.) on sodium valporate induced cytogenetic and testicular alterations in albino rats

    OpenAIRE

    Sakr, Saber A.; Zowail, Mohamed E.; Marzouk, Amera M.

    2014-01-01

    The present study investigated the cytogenetic and testicular damage induced by the antiepileptic drug, sodium valporate (SVP) in albino rats and the effect of saffron aqueous extracts. Treating rats with SVP caused a significant increase in the chromosomal aberrations either structural or numerical and decreased the mitotic index. Besides, animals administered SVP showed DNA damage appeared in the single strand breaks (comet assay). Testis of SVP-treated rats showed many histopathological ch...

  19. Comparison of the efficacy of sitagliptin with pioglitazone on dexamethasone-induced hepatic steatosis, dyslipidemia, and hyperglycemia in albino rats

    OpenAIRE

    Paul Mathai; Nagendra Nayak; Mamtha Rao; Nitasha Bhat, G. M.; K. Vinodraj; N Chandralekha; D Rajesh; T. K. Chethan

    2015-01-01

    Background: Sitagliptin is a dipeptidyl peptidase type 4 inhibitor. This study was done to assess the insulin-sensitizing effect of sitagliptin on Wistar albino rats by means of surrogate measures. Methods: There were four groups of six rats each. First group received dexamethasone alone in a dose of 8 mg/kg intraperitoneally for 6 days to induce metabolic changes and considered as dexamethasone control. Second group received sitagliptin 100 mg/kg orally 6 days before dexamethasone and 6 d...

  20. Comparison of the efficacy of liraglutide with pioglitazone on dexamethasone induced hepatic steatosis, dyslipidemia and hyperglycaemia in albino rats

    OpenAIRE

    Vinodraj, K.; Nagendra Nayak, I. M.; Rao, J. Vikram; Mathai, Paul; N Chandralekha; Nitasha, B.; D. Rajesh; T. K. Chethan

    2015-01-01

    Objectives: To evaluate the efficacy of liraglutide with pioglitazone for prevention of dexamethasone induced hepatic steatosis, dyslipidemia and hyperglycemia in Albino rats. Materials and Methods: There were four groups of six rats each. First group received dexamethasone alone in a dose of 8 mg/kg intraperitoneally for 6 days to induce metabolic changes and considered as dexamethasone control. Second group received liraglutide 1.8 mg/kg subcutaneously 6 days before dexamethasone and 6 days...

  1. Effect of Some Food Colorants (Synthetic and Natural products) of Young Albino RatsI- Liver and Kidney Functions

    OpenAIRE

    Eman G.E. Helal * Samir A.M. Zaahkouk

    2000-01-01

    Food colorants are used all over the world in great amount. However, their use in food is still controversial. It causes and will cause severe tension to the consumers as the sensitivity of people increases to general health. This work was carried out to study and compare between the possible toxic effect of some natural (tumeric, carmine and chlorophyll) and synthetic (fast green, annatto and sunset-yellow), food colorants on liver and kidney function of young male albino rats. Such effect m...

  2. Phytic Acid Exposure Alters AflatoxinB1-Induced Reproductive and Oxidative Toxicity in Albino Rats (Rattus norvegicus)

    OpenAIRE

    Abu El-Saad, Abdelaziz S.; Mahmoud, Hamada M.

    2009-01-01

    The increased use of feed in Egypt's aquaculture and animal industries raises concerns about the possible presence of mycotoxins in feedstuffs. The use of alternative medicine, such as botanicals and nutritional supplements, has become popular with inflammatory cases. The present study aimed to testify the role played by phytic acid (IP6) in enhancing the reproductive and oxidative toxicity induced in aflatoxinB1 (AFB1) treated white male albino rats (Rattus norvegicus) throughout treatment a...

  3. Evaluation of immunomodulatory activities of methanolic extract of khat (Catha edulis, Forsk) and cathinone in Swiss albino mice

    OpenAIRE

    Ketema, Tsige; Yohannes, Moti; Alemayehu, Esayas; Ambelu, Argaw

    2015-01-01

    Background The objective of this study was to explore the immunomodulatory effect of khat and its active component, cathinone, using mice. Materials and methods Female Swiss albino mice aged 7–8 weeks weighing 25-30 g were used in the study. Mice were randomized into eight groups of 6 each and oral treatment of khat crude extract and cathinone were given daily for four weeks. Physical, hematological, biochemical, and immunological parameters were measured. Immunological studies included humer...

  4. EXPERIMENTAL EVALUATION OF THE ANTI-ULCER ACTIVITY OF GRAPE (VITIS VINIFERA) SEED EXTRACT IN WISTAR ALBINO RATS

    OpenAIRE

    Anand M. Ingale; Vijaya Rajendran; Venkata BharatKumar Pinnelli

    2014-01-01

    Background: Peptic ulcer disease is a common condition of present day life, and its incidence is markedly increasing. The available drugs for the treatment are associated with adverse effects. Hence, there is a need for newer and better treatment for the same. Objectives: To evaluate the anti-ulcer activity of ethanolic extract of Vitis Vinifera (seed) by Water Immersion stress induced gastric ulcer model in Wistar albino rats using two doses (100, 200mg/kg body weight.) Methods: The antiu...

  5. THE USE OF CASSAVA ROOT MEAL AS A PARTIAL REPLACEMENT FOR CORN IN DIETS FOR ALBINO RATS

    Directory of Open Access Journals (Sweden)

    Thomas Nii NARKU NORTEY

    2016-07-01

    Full Text Available The experiment was carried out to determine if partial replacement of maize with cassava root meal (CRM in diets for albino rats will have an effect on performance, organ characteristics and blood parameters. Twenty five Sprague Dawley albino rats (F344 strain, initial body weight (216 ± 8g were randomly assigned to five treatments (T1 to T5 in a completely randomized (CRD arrangement. T1 was the control and contained zero CRM. T2 and T3 contained 30% CRM, while T4 and T5 contained 45% CRM. These levels of inclusion represented 50 and 75% replacement of corn in the diets respectively. T2 and T4 had 0.15% methionine (Met while T3 and T5 had 0.3% Met. The rats were each fed a single diet for 28d. Average daily feed intake (ADFI of rats on T1 was lower (P 0.05 in average daily gain (ADG and feed conversion efficiency (FCE. Similarly there were no differences (P>0.05 in carcass, viscera and other internal organ weights. Results of this trial indicate that albino rats can tolerate diets with added CRM (45% of the diet with no adverse effects on growth and internal organ characteristics. Future work will need to look at the possibility of using CRM at similar or higher levels in diets for growing pigs.

  6. Distribution and ultrastructure of pigment cells in the skins of normal and albino adult turbot, Scophthalmus Maximus

    Institute of Scientific and Technical Information of China (English)

    GUO Huarong; HUANG Bing; QI Fei; ZHANG Shicui

    2007-01-01

    The distribution and ultrastructure of pigment cells in skins of normal and albino adult turbots were examined with transmission electron microscopy (TEM). Three types of pigment cells of melanophore, iridophore and xanthophore have been recognized in adult turbot skins. The skin color depends mainly on the amount and distribution of melanophore and iridophore, as xanthophore is quite rare. No pigment cells can be found in the epidermis of the skins. In the pigmented ocular skin of the turbot, melanophore and iridophore are usually co-localized in the dermis. This is quite different from the distribution in larvae skin. In albino and white blind skins of adult turbots, however, only iridophore monolayer still exists, while the melanophore monolayer disappears. This cytological evidence explains why the albino adult turbot, unlike its larvae, could never resume its body color no matter what environmental and nutritional conditions were provided. Endocytosis is quite active in the cellular membrane of the iridophore. This might be related to the formation of reflective platelet and stability of the iridophore.

  7. Características ultraestruturais do segmento abdominal da aorta de rato albino = Mural features of the abdominal aortic segment of albino rat

    Directory of Open Access Journals (Sweden)

    2007-10-01

    Full Text Available O objetivo da presente pesquisa foi investigar as peculiaridades ultraestruturais da parede da aorta de rato. Foram utilizados sete ratos albinos, adultos jovens, dos quais foram coletados fragmentos da aorta abdominal infra-renal. Após a coleta, os segmentosvasculares foram fixados e encaminhados para a rotina de microscopia eletrônica de transmissão e varredura. As lamelas elásticas aparecem interpostas às fibras musculares lisas, sendo essa disposição principalmente notada na túnica média da parede vascular. Entre asfibras musculares lisas e as lamelas elásticas, observa-se um inter-relacionamento aparentemente estreito, feito por conexão e ancoramento entre ambos os elementos murais por meio de lamelas de colágeno. A túnica íntima da aorta abdominal do rato mostraalgumas peculiaridades ultraestruturais marcantes, tais como a interrupção, em certos locais da parede, de continuidade da lâmina elástica interna, interrupção acompanhada por poros endoteliais, de certa extensão, suprajacentes à falha na estrutura elástica intimal. Este padrão de constituição mural, com destaque aos ancoramentos elástico-musculares, via o colágeno, parece garantir propriedades fundamentais da parede vascular, concernentes à hemodinâmica, tal como o cisalhamento, normalmente notado entre os estratos superpostosda parede vascular, bem como a contratilidade e a visco-elasticidade da parede arterial.The objective of the present research was to investigate the ultrastructural peculiarities of the aortic wall of the rat. Seven young adult rats were used, from which fragments of theinfrarenal abdominal aorta were collected. After collection, the vascular segments were fixed and sent for analysis by scanning electron microscope. The elastic lamellae appear interposed with smooth muscular fibers; this pattern was verified mainly at the medial layer structure. Among the mural elements a well defined interrelationship was established through

  8. Patologías tratadas con oxigenoterapia hiperbárica en el Hospital Central de la Defensa

    Directory of Open Access Journals (Sweden)

    J.M. Torres León

    2015-06-01

    Full Text Available Introducción: La oxigenoterapia hiperbárica (OHB es una modalidad terapéutica que se fundamenta en la obtención de presiones parciales de oxígeno elevadas en sangre, al respirar oxígeno puro, en el interior de una cámara hiperbárica a una presión superior a la atmosférica. Sus acciones incluyen efectos hemodinámicos, acciones sobre la inmunidad y el transporte de O2. Este amplio espectro de efectos facilita que sus recomendaciones puedan incluir una gran variedad de indicaciones, algunas de ellas controvertidas. Objetivos: Conocer las patologías de los pacientes tratados con OHB en la Comunidad Autónoma de Madrid (CAM y revisar la evidencia científica al respecto. Método: En la actualidad la cámara hiperbárica del Servicio de MSB (Medicina Subacuática del HCD (Hospital Central de la Defensa es la de referencia en la CAM. Se revisaron las historias clínicas de los pacientes atendidos entre Febrero 2013 y Junio 2014. Se recogieron las siguientes variables: 1 Enfermos aceptados y desestimados para el tratamiento. 2 Edad y sexo de los pacientes tratados. 3 Patología por la que se indicaba el tratamiento. 4 Complicaciones observadas en relación con la OHB. Resultados: Se aceptaron para tratamiento 113 enfermos procedentes de 15 Hospitales de la CAM. Se desestimaron para tratamiento con OHB a 22 pacientes por patologías o tratamientos activos que no hacían aconsejable el tratamiento con OHB en ese momento. El 59,82 % eran hombres y el 40,18 % mujeres. Edad media 64,72 años. Las indicaciones principales de tratamiento fueron las lesiones radio inducidas 52,21 % de los casos (n=59 y las úlceras y heridas de evolución tórpida con mala respuesta a tratamiento convencional 23 % de los casos (n=26. El tratamiento tuvo que ser suspendido en 8 pacientes (7,14 % de los tratados por mala tolerancia o complicaciones leves. Discusión y conclusiones: Las indicaciones de OHB en nuestra muestra comprenden un amplio número de patolog

  9. sistema Web con JSP

    Directory of Open Access Journals (Sweden)

    César Viloria Núñez

    2014-01-01

    Full Text Available Este artículo presenta el desarrollo de un sistema de información que permite la adquisición y la administración de información relacionada con los signos vitales como la presión arterial, la frecuencia cardiaca y respiratoria, y la saturación de oxígeno en la sangre de un paciente. La implementación del sistema se basa en una solución Web, permitiendo así que médicos especialistas puedan monitorear a sus pacientes desde cualquier punto conectado a la red en tiempo real y, al mismo tiempo, dar indicaciones críticas al personal médico que se encuentra en el lugar con el paciente.

  10. Visualisation of cerebrospinal fluid flow patterns in albino Xenopus larvae in vivo

    Directory of Open Access Journals (Sweden)

    Mogi Kazue

    2012-04-01

    Full Text Available Abstract Background It has long been known that cerebrospinal fluid (CSF, its composition and flow, play an important part in normal brain development, and ependymal cell ciliary beating as a possible driver of CSF flow has previously been studied in mammalian fetuses in vitro. Lower vertebrate animals are potential models for analysis of CSF flow during development because they are oviparous. Albino Xenopus laevis larvae are nearly transparent and have a straight, translucent brain that facilitates the observation of fluid flow within the ventricles. The aim of these experiments was to study CSF flow and circulation in vivo in the developing brain of living embryos, larvae and tadpoles of Xenopus laevis using a microinjection technique. Methods The development of Xenopus larval brain ventricles and the patterns of CSF flow were visualised after injection of quantum dot nanocrystals and polystyrene beads (3.1 or 5.8 μm in diameter into the fourth cerebral ventricle at embryonic/larval stages 30-53. Results The fluorescent nanocrystals showed the normal development of the cerebral ventricles from embryonic/larval stages 38 to 53. The polystyrene beads injected into stage 47-49 larvae revealed three CSF flow patterns, left-handed, right-handed and non-biased, in movement of the beads into the third ventricle from the cerebral aqueduct (aqueduct of Sylvius. In the lateral ventricles, anterior to the third ventricle, CSF flow moved anteriorly along the outer wall of the ventricle to the inner wall and then posteriorly, creating a semicircle. In the cerebral aqueduct, connecting the third and fourth cerebral ventricles, CSF flow moved rostrally in the dorsal region and caudally in the ventral region. Also in the fourth ventricle, clear dorso-ventral differences in fluid flow pattern were observed. Conclusions This is the first visualisation of the orchestrated CSF flow pattern in developing vertebrates using a live animal imaging approach. CSF flow

  11. Microscopic Studies Of The Effect Of Some Food Additives On The Kidney Of Albino Rat

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    Abd El-Tawab M. Ismail - Ashraf M.Moustafa

    2003-09-01

    Full Text Available Recently the use of synthetic food coloring additives was increased and the levels of human exposure to such agents are very broad, thus feeding over long periods may continually possess potential hazards to the human health. Also most of the food colors tested in the conventional toxicity experiments showed toxic effects at very high level of intake i.e. 1-5 % in the diet. The aim of this study was to evaluate the histological and histochemical effects of some of these substances (Sodium nitrate and sunset yellow on the liver of adult albino rats. The study included three main parts: A. Histological studies on the liver under the effect of (Sodium nitrate and sunset yellow substances. Using paraffin sections, which were stained with Hx & Eosin, Masson Trichrome B. Evaluation of histochemical activity of both alkaline phosphates enzyme and succinic dehydrogenase enzymes on the renal tissue. C. Statistical evaluation using image analyzer to detect glomerular area, area percentage of collagen fibers distribution and optical density of both alkaline phosphatase enzyme activity in glomerulus and succinic dehydrogenase enzyme activity in renal tubules. Seventy adult male albino rats were used. Nitrate and sunset yellow were given orally through a gastric tube in dose of 1 mg / kg / b.w. daily. The animals were classified into seven groups. 1. Group I (Control group 2. Group II: The animals were given sodium nitrate in a dose of 1mg/kg/bwt for one month. 3. Group III: The animals were given sun set yellow in a dose of 1mg/kg/bwt/day for one month. 4. Group IV: The animals were given sodium nitrate and sunset yellow for one month in a dose of 1mg/kg/bwt/for each drug in a separate manner. 5. Group V: The animals were given sodium nitrate similar to the previous dose as group II for one month and left 2 weeks without oral intubations. 6. Group VI: The animals were given sun set yellow No 6 in a dose and route of administrations as group III for one

  12. Vertebral muscles of the back and tail of the albino rat (Rattus norvegicus albinus).

    Science.gov (United States)

    Brink, E E; Pfaff, D W

    1980-01-01

    The dorsal and ventral vertebral muscles of the back and the tail of the albino Norway rat are described and discussed. These muscles were analyzed because they are undoubtably used during the sexual posturing, lordosis, of the female rat, as well as participating in a variety of other behaviors. The muscles are described by region (thoracic-lumbar or sacrocaudal), and the classifications of Vallois are followed where possible. Of the epaxial (dorsal) muscles, the three longitudinal systems of muscles, the transversospinalis, the longissimus, and the iliocostalis systems, can be identified in the albino rat. Muscles of the transversospinalis system are fused in the lumbar region, distinct and specialized in the thoracic region, and form the tail muscle extensor caudae medialis caudally. The iliocostalis system of the lumbar region is fused with one component of the lumbar longissimus system to form lateral longissimus. Anteriorly, iliocostalis thoracis and cervicis represent the iliocostalis system. The lumbar longissimus system is represented by the longissimus component of lateral longissimus, medial longissimus, and a short-fiber component. Longissimus dorsi is the anterior continuation of the longissimus portion of the lateral longissimus. The short-fiber component also continues into the thoracic region, where it becomes difficult to separate out from longissimus dorsi. Medial longissimus represents the excursion into the lumbar region of the long, tendinous, tailbase-tail muscle, longissimus caudae; the caudal portion of this muscle is extensor caudae lateralis. The remaining dorsal muscle described is the tail muscle, abductor caudae dorsalis. The hyposomal (ventral) muscles described are quadratus lumborum and the intertransversarii, present in the lumbar region; the muslces iliococcygeus, pubococcygeus and coccygeus which arise from the medial face of the pelvis and insert onto the proximal tail; the long, tendinous, tail muscles, flexor caudae brevis and

  13. Protection of radiation-induced DNA damage in albino rats by Zingiber Montanum extract

    International Nuclear Information System (INIS)

    The tropical ginger, Zingiber montanum (J. König) A. Dietr, has potentials in scavenging free radicals and affording protection from radiation-induced chromosomal aberrations. The present investigation aims at determining antioxidant and radioprotective properties of the rhizome extract. Sulphur free radical, DPPH and superoxide scavenging assays were carried out for assessing antioxidant activities. Radiation-induced (500 cGy) DNA damage in pBR322 in vitro could be significantly reduced upto 71% (P < 0.05) by treatment with 60% ethanol extract (20 μg). Acute toxicity of the 60% ethanol extract was determined and suitable injectable dose was selected for intra-peritoneal administration in albino rats (Rattus norvegicus). The LD50 of extract calculated for 72 hrs was found to be 2.9 g/kg, and maximum tolerated dose (MTD) of rhizome extract was 1.3 g/kg. Rhizome extract (0.5 g/kg) in 60% ethanol was intra-peritoneally injected to albino rats and exposed to 100, 300 and 500 cGy. Radioprotective effect of the extract was determined by alkaline single cell comet assay. Significant reduction (P < 0.05) of comet DNA (68%) and length (61%)in rat bone marrow cells was observed at a radiation dose of 500 cGy. The results demonstrate that tropical ginger possess free radical scavenging properties and can protect bone marrow cells from radiation-induced DNA damages. The results on radiation induced DNA damage using plasmid pBR322 DNA obviously justify that the extract at a low dose can protect DNA from undergoing strand breakage due to gamma radiation exposure. Versatility of Zingiber montanum in different chemical assays in terms of its radical scavenging potential shows that this non-conventional food plant as a lot of potential in maintaining human health through dietary supplementation as nutraceutical. This candidate plant also can possibly be a promising candidate in clinical radiotherapy perhaps as a substitute of or the well-know radioprotector amifostine. (author)

  14. Structural And Histochemical Changes Of Albino Rat Kidney Under The Effect Of Injectable Contraceptive

    Directory of Open Access Journals (Sweden)

    Mamdouh A. Ghali

    2006-03-01

    Full Text Available The choice of safe and effective method for fertility control still under continuous search. So, discovery of structures having long duration of action which made administration by injection was an attractive alternative to oral contraceptives. Medroxyprogesterone acetate emerged from this early work as promising injectable long ­ acting contraceptive with minimal risk. This work was planned to evaluate the structural and histochemical changes induced by injectable contraceptive Depo-provera (MPA, on the kidney of adult female Albino rats as well as testing the degree of reversibility of changes that may develop after the arrest of its use. Thirty adult female Albino rats were used in this work and divided into three equal groups. Group I was used as a control, group II was intramuscularly injected with MPA 4 times (2.7 mg / rat every 3 oestrus cycles and sacrificed one day after arrest of the injection, while , group III the animals were injected with MPA by the same dose and sacrificed 30 days after arrest of the injection. The abdominal aorta was exposed and Indian ink injection was injected to study the renal vascular changes. The animals were sacrificed, the kidney was dissected and paraffin sections were prepared and stained by haematoxylin and eosin and PAS technique to study the microscopic structure and the distribution of PAS+ve materials respectively. Frozen sections were prepared and stained by both Gomori and Nachla's techniques to study the activity of acid phosphatase enzyme and succinic dehydrogenase enzyme respectively. The obtained data were statistically analyzed using Student's t.test. The injected groups showed atrophy of tubular epithelium, dilatation of tubular lumina. All recovery groups were nearly similar to normal state except PAS+ve material of renal tubules which were nearly similar to injected groups. The treated groups showed significant increase in vascular distribution and PAS+ve materials. While, non

  15. Effects of ciprofloxacin and zinc chloride in adult albino rat and pre-natal conceptus

    International Nuclear Information System (INIS)

    Background: Administration of quinolone therapy is controversial during growing age as stated by earlier authors. The flouroquinolones are currently not indicated for young children because of arthropathy and adverse effect as new born shown by studies. However the effects of ciprofloxacin and ZnCl/sub 2/ on prenatal conceptus have remained undocumented. The present study was designed to compare the effects on conceptus after maternal ingestion of ciprofloxacin and ZnCl/sub 2/ using Wastar albino rats. Methods: Ciprofloxacin and ZnCl/sub 2/ was administrated to pregnant female albino rats. Ciprofloxacin with a dose of 20 mg/Kg bodyweight and ZnCl/sub 2/ 120 micro g/100 gm bodyweight two times therapeutic dose for 10 days (from day 8-18 of pregnancy). Each animal was weighted on day 1, day 8 and day 18 of pregnancy. Abortion resulted on day 18th of pregnancy. Each group of pregnant animals were sacrificed on day 18 of gestation by over dose of either anaesthesia, abdomen opened, uterus and both cornua containing conceptus identified, removed, there weight recorded, crown rump length was measured and was compared with similar value of control animals. The results were statistically analysed to find out the significance. Results: The ciprofloxacin induces a mordanting effect as obviated by increased basophilia. Our study reveals that ciprofloxacin administered in maternal, decreased maternal body weight to 38.4+-0.9 gm. However simultaneous ZnCl/sub 2/ maintained the body weight to 41.4+-0.7 gm, while ZnCl/sub 2/ increased the body weight to 46.5+-2.25 gm. The body weight and Crown Rump length (CR Length) in conceptus decreased by 4.52+-0.10 gm and 3.06+-0.09 Cm respectively. That ciprofloxacin and ZnCl/sub 2/ administration maintained the body weight and CR length by 5.46+-0.09 gm and 3.79+-0.13 Cm respectively. That ZnCl/sub 2/ administration increased the body weight and CR length by 6.71+-0.05 gm and 4.15+-0.08 Cm respectively. Conclusion: Prenatal administration

  16. Proteomic analysis of young leaves at three developmental stages in an albino tea cultivar

    Directory of Open Access Journals (Sweden)

    Li Juan

    2011-08-01

    Full Text Available Abstract Background White leaf No.1 is a typical albino tea cultivar grown in China and it has received increased attention in recent years due to the fact that white leaves containing a high level of amino acids, which are very important components affecting the quality of tea drink. According to the color of its leaves, the development of this tea cultivar is divided into three stages: the pre-albinistic stage, the albinistic stage and the regreening stage. To understand the intricate mechanism of periodic albinism, a comparative proteomic approach based on two-dimensional electrophoresis (2-DE and mass spectrometry was adopted first time to identify proteins that changed in abundance during the three developmental periods. Results The 2-DE results showed that the expression level of 61 protein spots varied markedly during the three developmental stages. To analyze the functions of the significantly differentially expressed protein spots, 30 spots were excised from gels and analyzed by matrix-assisted laser desorption ionization-time of flight-tandem mass spectrometry. Of these, 26 spots were successfully identified. All identified protein spots were involved in metabolism of carbon, nitrogen and sulfur, photosynthesis, protein processing, stress defense and RNA processing, indicating these physiological processes may play crucial roles in the periodic albinism. Quantitative real-time RT-PCR analysis was used to assess the transcriptional level of differentially expressed proteins. In addition, the ultrastructural studies revealed that the etioplast-chloroplast transition in the leaf cell of White leaf No. 1 was inhibited and the grana in the chloroplast was destroyed at the albinistic stage. Conclusions In this work, the proteomic analysis revealed that some proteins may have important roles in the molecular events involved in periodic albinism of White leaf No. 1 and identificated many attractive candidates for further investigation. In

  17. pacientes con falla cardiaca

    Directory of Open Access Journals (Sweden)

    Diana Marcela Achury Saldaña

    2007-01-01

    Full Text Available Objetivo: determinar la adherencia al tratamiento de pacientes con falla cardiaca hospitalizados, al aplicar un plan educativo quefomenta el autocuidado.Método: estudio cuasiexperimental (entrevistas enfermera-paciente realizado entre diciembre de 2004 y mayo de 2006, con unamuestra de 50 pacientes seleccionados por conveniencia. Se diseñó un instrumento para evaluar los comportamientos de los pacientes,con base en algunos resultados de la adherencia y sus respectivos indicadores de la taxonomía NOC (Nursing out comes classification. Laadherencia al tratamiento fue medida en dos momentos: el primero durante la hospitalización, seguido de la aplicación del plan educativoantes del alta, que proporcionaba información en el manejo de su enfermedad desde una dimensión física, psicológica y social quepromueve el autocuidado; y el segundo un mes después del alta en su domicilio.Resultados: diferencias estadísticamente significativas (P=0,0001 que demuestran cómo mediante la capacitación al paciente enel manejo de su tratamiento farmacológico y no farmacológico, el establecimiento de una sana relación entre el profesional de enfermeríay el paciente, y la participación de la familia, se logra una total adherencia al tratamiento.Conclusiones: para lograr una adherencia total del paciente con falla cardiaca al tratamiento es necesario un proceso educativo y unseguimiento continuo y personalizado que motive permanentemente al paciente y se le reconozca el papel protagónico en su cuidado y manejo de la enfermedad.

  18. Contemos con la publicidad

    OpenAIRE

    Muñoz Santonja, José

    1995-01-01

    En este artículo se presentan algunas propuestas para utilizar la publicidad en clases de Matemáticas, como apoyo didáctico a algunos temas que hay que analizar en el currículum de esta materia a lo largo del curso. Se plantean, al mismo tiempo, una serie de actividades para realizar con la publicidad en el ámbito de la prensa escrita.

  19. Los experimentos con ajusticiados.

    OpenAIRE

    Bert, Paul

    2011-01-01

    Los experimentos realizados con ajusticiados se multiplican y son muy pocos los decapitados que escapan a las investigaciones más o menos preparadas y ejecutadas. Es conveniente indicar a los médicos y también al público lo que puede ser interesante intentar, lo que es inútil y sobretodo lo que no se puede permitir.

  20. Los impactos del Tratado de Libre Comercio de América del Norte en la producción de frijol de Zacatecas

    Directory of Open Access Journals (Sweden)

    Elivier Reyes Rivas

    2007-01-01

    Full Text Available La apertura comercial total, prevista en el Tratado de Libre Comercio de América del Norte (TLCAN para 2008, puede afectar la agricultura y el empleo rural de Zacatecas, particularmente la producción de frijol, donde la entidad ocupa el primer lugar como productor nacional. Dicha leguminosa ocupa 57 por ciento del área sembrada en el estado y emplea a cerca de 70 mil personas. Al revisar los términos comerciales pactados, datos estadísticos y fuentes primarias, se concluye que la competitividad que genere la apertura comercial puede precipitar el abandono de los cultivos y el deterioro de las condiciones de vida de miles de agricultores. El gobierno mexicano debería reevaluar los términos del tratado para impulsar la producción agrícola y establecer políticas públicas nuevas generadoras de empleo.

  1. Perfiles genéticos (IS6110 y patrones de resistencia en aislamientos de M. tuberculosis de pacientes con tuberculosis pulmonar. Lima Sur, Perú

    Directory of Open Access Journals (Sweden)

    Luis Capcha A

    2005-03-01

    Full Text Available Objetivos: Conocer los perfiles genéticos de M. tuberculosis y determinar el patrón de resistencia a drogas en una población de sujetos infectados provenientes del sur de Lima mediante el marcador genético IS6110 (RFLP-IS6110. Materiales y Métodos: Entre octubre de 2002 y abril de 2003 se incluyeron pacientes mayores de 15 años con tuberculosis (TB pulmonar frotis positivo procedentes de servicios de salud del distrito Villa María del Triunfo y del Hospital María Auxiliadora. Se realizó la prueba de sensibilidad a las cuatro drogas de primera línea rifampicina (RIF, isoniacida (INH, estreptomicina (SM y etambutol (EMB por el método de proporciones, y la genotipificación mediante el método estándar de RFLP-IS6110. Se recolectó información de los casos de los registros del establecimiento e historias clínicas. Resultados: De 118 aislamientos de M. tuberculosis se identificaron 97 perfiles genéticos variando entre 2 a 15 bandas por perfil. El 29,7% de los aislamientos dio origen a 14 grupos o clusters genéticos mientras que el resto mostró patrones variables de bandas. De otro lado, los perfiles de resistencia revelaron que cerca de 33% de los sujetos participantes nunca tratados presentaron resistencia a drogas y 58% de los tratados con anterioridad. La multidrogoresistencia fue de 8,42% y 36% en los nunca y anteriormente tratados respectivamente. Conclusiones: Nuestro análisis revela la existencia de grupos genéticos con relación epidemiológica o clonal sin evidencia de transmisión de cepas resistentes a múltiples drogas.

  2. La moneda castellana en los manuales de mercaderías y tratados de aritmética italianos bajomedievales (siglos XIII-XV)

    OpenAIRE

    González Arévalo, Raúl

    2007-01-01

    El presente artículo analiza el conocimiento sobre la moneda y el sistema monetario vigentes en Castilla en la Baja Edad Media en los manuales de mercadería y los tratados de aritmética italianos de los siglos XIII al XV. The present paper analyzes the knowledge of money and money system in Castile in the Late Middle Ages in the Italian pratiche di mercatura and treaties of Arithmetics from the XIIIth to XVth Centuries.

  3. Tratamiento con caspofungina de endocarditis por Candida tropicalis resistente a fluconazol Treatment with caspofungin of Candida tropicalis endocarditis resistant to fluconazol

    Directory of Open Access Journals (Sweden)

    Marcelo del Castillo

    2004-04-01

    Full Text Available Las endocarditis causadas por hongos, (Candida en particular, requieren tratamiento médico-quirúrgico, siendo la anfotericina B la droga de elección. Caspofungina es una equinocandina con gran actividad sobre Candida y Aspergillus. Se presenta un paciente con una endocarditis por Candida tropicalis resistente a fluconazol tratado con caspofungina bajo un esquema de salvataje, luego de haber presentado efectos adversos por anfotericina B. El paciente tuvo respuesta microbiológica.Fungal endocarditis, in particular due to Candida species, requires medical and surgical treatment and amphotericin B is the drug of choice. Caspofungin is an echinocandin very effective against Candida and Aspergillus. We present a patient with Candida tropicalis endocarditis, fluconazol resistant, treated with caspofungin, on a compassional basis as a result of adverse effects with amphotericin B. The patient had a microbiological response.

  4. Outcome of sporadic amyotrophic lateral sclerosis treated With non-invasive ventilation and riluzole Sobrevida en pacientes con esclerosis lateral amiotrófica esporádica tratados con ventilación no invasiva y riluzole

    OpenAIRE

    Martín Sívori; Gabriel E. Rodríguez; Daniel Pascansky; César Séenz; Roberto E.P. Sica

    2007-01-01

    Sporadic amyotrophic lateral sclerosis (sALS) is a progressive degenerative motor neuron disorder lacking specific treatment. Riluzole is the only drug able to modestly slow down the course of the disease. Respiratory insufficiency is the main cause of death; non invasive ventilation (NIV) has shown to improve survival. Our aim was to evaluate the effect of NIV and riluzole on survival. Ninety seven patients with a diagnosis of sALS were assessed and followed up for 60 months. Twenty nine pat...

  5. Segumiento de la carga tumoral en pacientes con leucemia mielode crónica de novo y en remisión citogenética completa tratados con imatinib en Colombia

    Directory of Open Access Journals (Sweden)

    Gonzalo Guevara

    2012-12-01

    Full Text Available Normal 0 21 false false false ES X-NONE X-NONE Objective: To evaluate the hematological, cytogenetic, and molecular responses in Colombian patients with CML chronic myeloid leukemia (CML treated with imatinib. Methods: Two groups of patients, one with the novo diagnostic and another in state of complete cytogenetic remission were followed for 12 months with quantitative PCR evaluations every three months and with chromosomal analysis every 6 months. Results: The group with the novo diagnosis showed 50% of complete cytogenetic remission at 12 months while the other 50% were considered to have primary resistance. Respect the molecular analysis, 10.5% of the patients reached undetectable BCR-ABL transcripts at 12 months. In the complete cytogenetic remission group, 10.6% lost the state of complete cytogene­tic remission at 12 months, 50% reached undetectable BCR-ABL transcripts but 10% showed levels higher than 10%, which in our standardization was equal to no molecular response. Conclusions: Despite having received the conventional dosages of 400 mg/day of imatinib, the cytogenetic and molecular responses obtained in our group of Colombian patients with CML, were lower than those in other international studies.

  6. Three-dimensional verification of prostate cancer patients treated with VMAT by Matrixx detector and COMPASS software IBA; Verificacion tridimensional de pacientes con cancer de prostata tratados con VMAT mediante el detector Matrixx y software COMPASS de IBA

    Energy Technology Data Exchange (ETDEWEB)

    Mateos, J. C.; Luis, F. J.; Cabrera, P.; Carrasco, M.; Sanchez, G.; Herrador, M.

    2011-07-01

    Described in this paper the verification of prostate cancer patients treated with VMAT planned in our hospital, with a prescribed dose of 76 Gy. The ability to simultaneously analyze the patient by any plane COMPASS software (IBA, Germany), together with the detector array Matrixx-Evolution, this system gives a particularly interesting feature. The aim of this paper is to describe the operation of this equipment and validated for patient dosimetry in IMRT and VMAT treatments.

  7. Estudio lectinhistoquímico del aparato mucociliar de pollos infectados experimentalmente con Mycoplasma gallisepticum y tratados con mucolítico y antibiótico

    OpenAIRE

    Petruccelli, Miguel Ángel; Píscopo, Miguel V.; Unzaga, María Florencia; Cerdá, Raúl Oscar; Marino, F. P.

    2003-01-01

    La micoplasmosis aviar es una enfermedad que produce importantes pérdidas económicas, no sólo por la mortandad sino también por sus efectos en la conversión alimenticia. Afecta principalmente el árbol respiratorio siendo estos exacerbados por la presencia de otros agentes. El mucus es una barrera natural de protección no solo física sino también inmunológica, cuya composición química son principalmente glicoconjugados, los que pueden determinarse a través de técnicas de lectinhistoquímica. El...

  8. Evaluación de la expresión de las proteínas PPARγ Y NFκB en vellosidades intestinales de ratones adultos ICR infectados con rotavirus ECwt y tratados con pioglitazona

    OpenAIRE

    Gómez Moreno, Dory Lineth

    2013-01-01

    ANTECEDENTES Rotavirus es la principal causa de diarrea severa en niños menores de cinco años de edad en todo el mundo, según la OMS, rotavirus causa aproximadamente 527.000 muertes cada año (1). Dos vacunas de rotavirus vivos atenuados (Rotarix ™) y (RotaTeq ™) están disponibles actualmente (2). Aunque estas vacunas han demostrado su eficacia, no evita la aparición de los síntomas y muchos niños permanecen sin vacunar. Por consiguiente, se necesitan alternativas farmacológicas para el tra...

  9. Realización y corrección automática de exámenes con hoja de cálculo

    Directory of Open Access Journals (Sweden)

    Sánchez García, Juan Francisco

    2007-01-01

    Full Text Available La forma habitual de realizar exámenes de tipo test es mediante formularios en papel que posteriormente son tratados con un escáner y un software específico que facilita la corrección así como la emisión de informes y la exportación de datos a aplicaciones de hoja de cálculo. En las asignaturas de informática de gestión llama la atención que en algunos casos se hace evaluación de términos informáticos y utilización de aplicaciones informáticas sobre papel, cuando el hacerlo directamente sobre el ordenador permitiría además comprobar los conocimientos prácticos del alumno.Con la idea de facilitar al alumno la cumplimentación de este tipo de exámenes hemos desarrollado una metodología propia utilizando la hoja de cálculo Microsoft Excel. De esta forma el formulario de examen se sustituye por un fichero de hoja de cálculo que posteriormente será tratado para obtener los resultados contenido en el mismo y facilitar su corrección, la cual también se efectuará con la propia hoja de cálculo, utilizando programación en Visual Basic para Aplicaciones (VBA.

  10. Relación de la calidad de vida con diferentes modelos de atención domiciliaria en enfermos oncológicos terminales de un área sanitaria de Madrid

    Directory of Open Access Journals (Sweden)

    Agra Varela Yolanda

    2003-01-01

    Full Text Available Fundamentos: En este trabajo se evalúa la efectividad de los cuidados paliativos a domicilio con el objetivo de determinar si los enfermos con cáncer terminal tratados por Equipos de Soporte de Atención Domiciliaria presentan mejor calidad de vida que los tratados por Equipos de Atención Primaria. Métodos: Estudio prospectivo cuasi experimental realizado en el Área 4 del Imsalud de Madrid con enfermos referidos desde el hospital a Equipos de Soporte de Atención Domiciliaria o a Equipos de Atención Primaria. La variable estudiada fue la calidad de vida medida a través del Rotterdam Symptom Check List y el Hospital Anxiety and Depression Scale. Para el análisis estadístico se utilizó MANOVA, ANOVA de medidas repetidas y el test de Friedman. Resultados: 165 enfermos fueron tratados por Equipos de Soporte de Atención Domiciliaria y 56 por Equipos de Atención Primaria. Los primeros presentaron mejor puntuación en las escalas global (diferencia de medias: 9,5; IC 95%: 2,3-16,67 y dolor (diferencia de medias: 6,4; IC 9%: 1,14-11,43 del Rotterdam Symptom Check List en la primera semana del estudio. El tamaño del efecto fue mayor en el grupo Equipos de Soporte de Atención Domiciliaria. La prescripción de fármacos y el lugar de la muerte fue diferente en ambos grupos. Conclusiones: Al principio del estudio los enfermos tratados por Equipos de Soporte de Atención Domiciliaria presentaron una mejor percepción del estado de salud que los tratados por Equipos de Atención Primaria. No obstante, el importante número de pérdidas a lo largo del mismo hace que haya que mirar estos resultados con precaución.

  11. RELACIÓN DE LA CALIDAD DE VIDA CON DIFERENTES MODELOS DE ATENCIÓN DOMICILIARIA EN ENFERMOS ONCOLÓGICOS TERMINALES DE UN ÁREA SANITARIA DE MADRID

    Directory of Open Access Journals (Sweden)

    Yolanda Agra Varela

    2003-01-01

    Full Text Available Fundamentos: En este trabajo se evalúa la efectividad de los cuidados paliativos a domicilio con el objetivo de determinar si los enfermos con cáncer terminal tratados por Equipos de Soporte de Atención Domiciliaria presentan mejor calidad de vida que los tratados por Equipos de Atención Primaria. Métodos: Estudio prospectivo cuasi experimental realizado en el Área 4 del Imsalud de Madrid con enfermos referidos desde el hospital a Equipos de Soporte de Atención Domiciliaria o a Equipos de Atención Primaria. La variable estudiada fue la calidad de vida medida a través del Rotterdam Symptom Check List y el Hospital Anxiety and Depression Scale. Para el análisis estadístico se utilizó MANOVA, ANOVA de medidas repetidas y el test de Friedman. Resultados: 165 enfermos fueron tratados por Equipos de Soporte de Atención Domiciliaria y 56 por Equipos de Atención Primaria. Los primeros presentaron mejor puntuación en las escalas global (diferencia de medias: 9,5; IC 95%: 2,3-16,67 y dolor (diferencia de medias: 6,4; IC 9%: 1,14-11,43 del Rotterdam Symptom Check List en la primera semana del estudio. El tamaño del efecto fue mayor en el grupo Equipos de Soporte de Atención Domiciliaria. La prescripción de fármacos y el lugar de la muerte fue diferente en ambos grupos. Conclusiones:Al principio del estudio los enfermos tratados por Equipos de Soporte de Atención Domiciliaria presentaron una mejor percepción del estado de salud que los tratados por Equipos de Atención Primaria. No obstante, el importante número de pérdidas a lo largo del mismo hace que haya que mirar estos resultados con precaución.

  12. Evaluación y programas de intervención psicoeducativa en niños con tumores en el cerebelo

    OpenAIRE

    Grau Rubio, Claudia; Fortes del Valle, M. Carmen

    2003-01-01

    Se describen las secuelas neurológicas en niños diagnosticados de un tumor en el cerebelo y se ofrecen los resultados de la evaluación de 39 niños, con tumor en el cerebelo, tratados en la Unidad de Oncología Pediátrica del Hospital Infantil “La Fe” de Valencia. Asimismo, se compara la evaluación de secuelas de dos niños de educación infantil afectados de un tumor en el cerebelo: Yolanda (meduloblastoma, PNET) y Santiago (astrocitoma cerebeloso), y se describen las áreas en las que es acon...

  13. Análisis de regresión con datos imprecisos: Un nuevo enfoque que utiliza distancias difusas y sus aplicaciones

    OpenAIRE

    Aguilar-Peña, María-de-la-Concepción

    2015-01-01

    [ES] El análisis de regresión es una herramienta estadística potente con muchas aplicaciones en diferentes áreas. Este problema en un entorno difuso ha sido tratado en la literatura desde diferentes puntos de vista y teniendo en cuenta una variedad de datos de entrada/salida (reales o difusos). En esta memoria se presenta una nueva metodología basada en una familia de medidas de distancia difusas entre números difusos arbitrarios que se define utilizando algunas de las características posibi...

  14. Seguridad y eficacia de un concentrado de complejo protrombínico en pacientes con coagulopatía y hemorragia

    OpenAIRE

    N. Martínez-Calle; M. Marcos-Jubilar; Alfonso, A.; M Hernández; Hidalgo, F.; R. Lecumberri; J.A. Páramo

    2014-01-01

    Fundamento: Los concentrados de factores del complejo protrombínico (CCP) están indicados para reversión del efecto de antagonistas de vitamina K (AVK). Recientemente se han utilizado en el manejo de la coagulopatía de la hemorragia masiva. El objetivo del presente trabajo es evaluar la seguridad y eficacia del CCP en dos situaciones clínicas, para reversión de AVK y manejo integral de la hemorragia masiva. Material y métodos: Revisión retrospectiva de los casos tratados con CCP entre enero d...

  15. Asociación de sobrepeso y uso de glucocorticoides con componentes del síndrome metabólico en pacientes oncológicos en quimioterapia

    Directory of Open Access Journals (Sweden)

    Karla Sánchez-Lara

    2013-02-01

    Full Text Available En pacientes con diagnostico de cáncer en tratamiento con quimioterapia es común encontrar componentes del síndrome metabólico (SM como sobrepeso, obesidad, resistencia a la insulina e hiperglicemia. Estos componentes se han asociado a mayor recurrencia de la enfermedad. Objetivos: describir la relación entre el IMC, el uso de glucocorticoides y el sitio de tumor con los factores del SM en pacientes tratados con quimioterapia de un centro hospitalario universitario. Métodos: Estudio retrospectivo donde se revisaron expedientes de pacientes tratados en el centro oncológico del 2008 al 2010, con diagnóstico de cáncer y en tratamiento con quimioterapia sistémica. Se recopilo información acerca de datos antropométricos y criterios de SM definidos por ATP III. Resultados: Se incluyeron 158 pacientes, 75,9% genero femenino, los tumores mas comunes fueron mama, gastrointestinal y pulmón. Más de la mitad de los pacientes presentaron >3 componentes del SM (56,3%; El 43,6% de pacientes recibieron dexametasona como parte del tratamiento. El IMC promedio fue de 25,3 Kg/m². El diagnostico de cáncer de mama en tratamiento con quimioterapia se asoció con la presencia de 3 o más componentes del SM. La administración de glucocorticoides no se asoció a la presencia de SM. Conclusiones: los sujetos con IMC>25 tienen 12,6 veces más el riesgo de padecer SM, independientemente del uso de glucocorticoides en el tratamiento. El mantenimiento de un peso adecuado en el paciente oncológico es importante para reducir los factores de riesgo del SM.

  16. Antiovulatory and estrogenic activity of Plumbago rosea leaves in female albino rats

    Directory of Open Access Journals (Sweden)

    Sheeja E

    2009-01-01

    Full Text Available Objective : To evaluate the effect of petroleum ether (60-80, chloroform, acetone, ethanol and aqueous extracts of Plumbago rosea leaves on the estrous cycle and to identify the estrogenic activity of active acetone and ethanol extracts in female albino rats. Methods : Plant extracts were tested for their effect on the estrous cycle at two dose levels: 200 and 400 mg/kg, respectively. The effective acetone and ethanol extracts were further studied on estrogenic activity in rats. Histological studies of the uterus were carried out to confirm their estrogenic activity. Results : The acetone and ethanol extracts were most effective in interrupting the normal estrous cycle of the rats (P< 0.05, < 0.01, < 0.001. These later exhibited prolonged diestrous stage of the estrous cycle with consequent temporary inhibition of ovulation. The antiovulatory activity was reversible on discontinuation of treatment. Both the extracts showed significant estrogenic and antiestrogenic activity. Conclusion : The acetone and ethanolic extracts of P. rosea leaves have an antifertility activity.

  17. Possible Role of Humoral Immunity on Liver Dysfunction in Male Albino Rats

    International Nuclear Information System (INIS)

    Fifty male albino rats were used in this study to correlate liver function after curcumin or/and malathion intake with the levels of immunoglobulin G (IgG) and immunoglobulin M (IgM). The rats were divided into four groups, the first was the control group, the second was given malathion in drinking water (200 ppm), the third was administrated curcumin orally (70 mg/kg b.w.) 5 times /week while the fourth group received both malathion and curcumin with the same previous concentrations. Liver state was evaluated every 10 days by estimating prothrombine time (P.T.) and concentration (PC) and albumin level from blood taken from the retroorbital vein of 5 rats of the malathion group. After 40 days when there is prolongation of P.T. and hypoalbuminemia, ten rats from each group were decapitated. Liver enzymes, total protein, glucose, insulin, IgG and IgM were estimated. The data revealed that there is an increase of liver enzymes, glucose, insulin, and immunoglobulins (IgG) and (IgM) in malathion group and positive correlation between liver enzymes and immunoglobulins. These results denoted that the increase of immunoglobulins after malathion intake had no beneficial effects on the prognosis of liver condition, on the contrary, it may worsen liver state if there is some element of auto immunity, as well as the study proved that turmeric has the potential to improve the toxic effects of Malathion, whether on the functions of the liver or immune globulins.

  18. Antioxidant activity of lycopene extracted from tomato pomace toward gamma irradiation hazards in male albino rats

    International Nuclear Information System (INIS)

    The present study aims to evaluate the anti oxidative activity of lycopene extracted from tomato pomace against hazards induced by gamma irradiation. Male Swiss albino rats were orally administered by lycopene (1.2 mg/rat/day) using suitable stomach tube 7 days before exposure to a sublethal single dose (6.5 Gy) of whole body gamma radiation. Lipid peroxides (MDA) levels in plasma, reduced glutathione (GSH) content and superoxide dismutase activity in blood were determined, as well as serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma glutamyl transferase activity (GGT) were investigated 7 and 15 days post-irradiation and/or lycopene administration. The results revealed that exposure to ionizing radiation resulted in significant elevation in plasma levels of MDA, serum ALT, AST, ALP and GGT, as well as significant reduction in GSH content and superoxide dismutase activity in blood. Administration of lycopene by using suitable stomach tube pre-irradiation has significantly ameliorated the radiation-induced disturbances in all the investigated parameters

  19. Physiological and biochemical studies on the effect of septilin on irradiated male albino rats

    International Nuclear Information System (INIS)

    The present study has been initiated to evaluate the radioprotective effect of septilin against whole body gamma radiation and identifying the mechanism whereby septilin extract could protect against radiation toxicity. Irradiation induced significant increase in the serum enzymes of liver ASAT, ALAT, ALP, GGT activities and total bilirubin level when rats exposed to both gamma irradiation doses while direct bilirubin level rise when rats exposed to 6 Gy gamma irradiation only. There was a significant increase in total cholesterol, triglycerides and LDL cholesterol with significant decrease in HDL cholesterol. Besides, it produced high levels of liver malondialdehyde, nitric oxide while serum nitric oxide rise when rats exposed to 6 Gy gamma irradiation only with significant decrease in total glutathione in liver and liver superoxide dismutase activity. Irradiation induced significant decrease in WBCs, RBCs, Hb, PCV, platelets count and blood indices.Septilin manifested good melioration in the radiation-induced changes in the studied parameters and histopathological changes. Hence, it could be concluded that septilin plays a beneficial radioprotective role against radiation hazard in male albino rats.

  20. Stimulatory Effects of Dihydroartemisinin on the Leucocyte Population of Wistar Albino Rats

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    U. A. Utoh-Nedosa

    2011-01-01

    Full Text Available Problem statement: Five dosages of Dihydroartemisinin (DHA which included 1mg kg-1; a repeated dose of 1; 2; 60 and 80 mg kg-1 were administered orally to albino rats for 5 days. The results of the study showed that dihydroartemisinin treatment significantly elevated the total white cell count (pApproach: By increasing the population of neutrophils, lymphocytes and monocytes (which engage in chemo tactic response; microbial killing; microbial ingestion and antibody production in the blood, dihydroartemisinin demonstrated that it stimulates increase in their population and uses them as part of its own arsenals of warfare against endoparasites (like malaria parasites and pathogens. Results: The results of this study show that dihydroartemisinin stimulated a lot of new white blood cell production by haemopoetic sites of the body The increases in the total white blood cell count; the percentage neutrophils count and the percentage lymphocyte counts were significant at pConclusion: The results of the study suggest that the phagocytic and immunological activities of the body’s white blood cell population are important components of the efficacious Plasmodium Schizonticidal actions of Dihydroartemisinin in malaria treatment.