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Sample records for alba doctorado curricular

  1. Propuesta de un perfil profesional para el diseño del doctorado curricular colaborativo en estomatología

    Directory of Open Access Journals (Sweden)

    Dadonim Vila Morales

    2013-03-01

    Full Text Available El perfil profesional constituye un modelo, una idealización de las características, conocimientos, habilidades que debe poseer el egresado de cualquier nivel de estudios tanto terciario como del cuarto nivel. La Facultad de Estomatología de la Universidad de Ciencias Médicas de La Habana ha estado trabajando en pro de desarrollar un doctorado curricular en ciencias estomatológicas. Esta investigación pedagógica tuvo como propósito analizar teóricamente la importancia del perfil profesional y proponer un diseño de perfil profesional para un doctorado curricular colaborativo en ciencias estomatológicas. Se realizó una revisión bibliográfica de los fundamentos teóricos-metodológicos del perfil profesional, se analizó su implementación en el diseño curricular. Se señaló la importancia de un perfil de egresado correctamente instrumentado como sustento teórico-pedagógico, socio-crítico.

  2. Las concepciones de curriculum y su importancia en la elaboración de un doctorado curricular en estomatología The curriculum concepts and its significance in designing of a curricular doctorate in Stomatology

    Directory of Open Access Journals (Sweden)

    Dadonim Vila Morales

    2011-09-01

    Full Text Available El diseño curricular es una etapa esencial del proceso de enseñanza-aprendizaje. En dependencia de la concepción teórica y epistemológica que se tenga del curriculum, así será la estructuración de los procesos educativos y del tipo de pedagogía a implementar. En Cuba la Facultad de Estomatología cuenta con una amplia experiencia de 110 años en la formación de recursos humanos; sin embargo, se considera que la preparación de posgrado en esta ciencia debe ser fortalecida. Es por ello que este trabajo tuvo como objetivo evaluar las concepciones curriculares aplicables a la formación doctoral de posgrado en estomatología y proponer un posicionamiento crítico respecto al concepto de curriculum, que siente bases teóricas para el diseño de un doctorado curricular colaborativo en la mencionada profesión. La posición conceptual de curriculum de este estudio fue totalmente coincidente con el concepto del Centro de Perfeccionamiento de la Educación Superior de la Universidad de La Habana, pues destaca el plano estructural-formal, donde se concreta el proyecto elaborado, que se expresa en documentos, normativas y reglamentos del curriculum oficial, y a la vez se destaca el plano procesual-práctico, o sea, el proceso de realización curricular que se identifica con las prácticas educativas de posgrado.The curricular design is an essential stage of teaching-learning process. Depending of the theoretical and epistemologic concept on curriculum, will be the structuring of teaching process and of the type of pedagogy to be applied. In Cuba, the Stomatology Faculty has a broad experience of 110 years in the training of human resources; however it is considered that the postgraduate training in this science must to be strengthened. That is aim of present paper was to assess the curricular concepts applicable to doctoral training of postgraduate in Stomatology and to propose a critical location regarding the concept of curriculum, creating

  3. CALIFICANDO EL TRABAJO DE UN ESTUDIANTE DE DOCTORADO EN EDUCACIÓN MUSICAL

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    Robert E. Stake

    2010-01-01

    Full Text Available En este artículo reflexiono sobre los estudios de caso cualitativos tomando como ejemplo el trabajo de un estudiante de doctorado con formación en educación musical y la justificación que preparé para calificarlo. La educación musical es un buen campo curricular para mostrar que el todo es mucho más que la suma de sus partes y que las interpretaciones educativas surgen de nuestra experiencia personal, sin importar cuánto sepamos, en este caso, de música.

  4. El doctorado en Derecho: 1930-1956

    OpenAIRE

    Martínez Neira, Manuel; Puyol Montero, José María

    2008-01-01

    El estudio del doctorado permite individualizar distintos niveles de análisis e interpretación. Por un lado, un nivel reglamentario, análisis de las distintas normas jurídicas que se han ido acumulando en el tracto cronológico de la universidad contemporánea. Otro nivel está constituido por lo que podemos llamar la práctica administrativa, es decir, el desarrollo material de esas disposiciones. Un estudio de los expedientes académicos, de los instrumentos burocráticos, de las memorias y una e...

  5. Análisis de usabilidad de las webs de doctorado UPC

    OpenAIRE

    Coello Casado, Víctor

    2014-01-01

    En este proyecto se realiza un el estudio de usabilidad de dos de las páginas web de doctorado de la UPC, doctorat.upc.edu y gedad.upc.edu. Este estudio se ha realizado en base al análisis de mejores prácticas de usabilidad web y en testeos con usuarios.

  6. Herba-Alba

    African Journals Online (AJOL)

    2018-01-01

    Jan 1, 2018 ... Antioxidant activity of CE, SE, ME and UE ethanolic extract from Artemisia Herba- alba against DPPH˙ radicals. 2.2.3 ABTS assay. The scavenging activity from different technique was calculated. Table 2 and Fig.2 shows that all extracts analysis in this study inhibit ABTS radical potential. The IC50 of ABTS ...

  7. Interactions of archaeal chromatin proteins Alba1 and Alba2 with nucleic acids.

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    Miha Črnigoj

    Full Text Available BACKGROUND: Architectural proteins have important roles in compacting and organising chromosomal DNA. There are two potential histone counterpart peptide sequences (Alba1 and Alba2 in the Aeropyrum pernix genome (APE1832.1 and APE1823. METHODOLOGY/PRINCIPAL FINDINGS: THESE TWO PEPTIDES WERE EXPRESSED AND THEIR INTERACTIONS WITH VARIOUS DNAS WERE STUDIED USING A COMBINATION OF VARIOUS EXPERIMENTAL TECHNIQUES: surface plasmon resonance, UV spectrophotometry, circular dichroism-spectropolarimetry, gel-shift assays, and isothermal titration calorimetry. CONCLUSIONS/SIGNIFICANCE: Our data indicate that there are significant differences in the properties of the Alba1 and Alba2 proteins. Both of these Alba proteins can thermally stabilise DNA polynucleotides, as seen from UV melting curves. Alba2 and equimolar mixtures of Alba1/Alba2 have greater effects on the thermal stability of poly(dA-dT.poly(dA-dT. Surface plasmon resonance sensorgrams for binding of Alba1, Alba2, and equimolar mixtures of Alba1/Alba2 to DNA oligonucleotides show different binding patterns. Circular dichroism indicates that Alba2 has a less-ordered secondary structure than Alba1. The secondary structures of the Alba proteins are not significantly influenced by DNA binding, even at high temperatures. Based on these data, we conclude that Alba1, Alba2, and equimolar mixtures of Alba1/Alba2 show different properties in their binding to various DNAs.

  8. Technetium uptake by Sinapis Alba

    International Nuclear Information System (INIS)

    Mueller, H.; Ter Meer-Bekk, Ch.

    1986-01-01

    Transfer factors for pertechnetate uptake was determined for Sinapis Alba cultured hydroponically. For the freshly harvested, undried plants transfer factors were found between 13 and 40 depending on the growth period. (author)

  9. La atenuación en las “Conclusiones” de las tesis de doctorado

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    Esperanza Acín Villa

    2016-07-01

    Full Text Available Este trabajo es un primer acercamiento al estudio de la atenuación en el apartado “Conclusiones” de las tesis de doctorado en español. Se toma como punto de partida el concepto de atenuación y la metodología descriptiva y de análisis propuesta y desarrollada por el grupo Es.Var.Atenuación, que se adaptan a las características propias del discurso académico especializado y concretamente de la tesis doctoral. Se estudia un corpus compuesto por las “Conclusiones” de 50 tesis de doctorado escritas en España en los últimos años, en las que se descubre la atenuación a través de un número limitado de procedimientos, por medio de los cuales los autores se ocultan y relativizan sus afirmaciones tal como requieren tanto la retórica como las convenciones de escritura académicas.

  10. Curricular Guidelines for Neuroanatomy.

    Science.gov (United States)

    Journal of Dental Education, 1981

    1981-01-01

    Presented are the curricular guidelines for Neuroanatomy developed by the Section on Anatomical Sciences of the American Association of Dental Schools for use by individual educational institutions as curriculum development aids. Included are recommendations for primary educational goals, prerequisites, scope, content, behavioral objectives,…

  11. Concepción y estructuras diferentes del doctorado para formar investigadores.

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    Edmundo Resenos Díaz

    2013-11-01

    Full Text Available El Programa de Doctorado en Ciencias, con especialidad en ciencias administrativas, de la Escuela Superior de Comercio y Administración del Instituto Politécnico Nacional (IPN hasta 1995 era de tipo escolarizado, por asignaturas. El tiempo promedio que consumían los alumnos para concluir el  programa y graduarse era de 11 años. En ese año, el IPN autorizó, de manera oficial, establecer el programa reestructurado, nuevo para nuestro ambiente en esa época. Los objetivos principales del programa fueron: a formar investigadores, b incrementar la eficiencia terminal. Los supuestos, hipótesis y estrategias principales que sustentaban la propuesta fueron:   - El grado de Doctor en Ciencias es el nivel más elevado de educación formal que existe en el sistema de educación nacional y del mundo.   - Los aspirantes que ingresan al programa ya son autodidactas, al menos, saben estudiar por cuenta propia, ostentan un grado de maestría, por lo tanto, pueden adquirir por sí mismos todos los conocimientos, los que les falten o necesiten para culminar su formación.   - Los investigadores se forman haciendo investigación, no asistiendo al aula a escuchar profesores doctos que les trasmiten sus conocimientos y experiencias.   - La práctica hace al investigador, no los ejercicios y prácticas escolares diseñadas por la experiencia de diversos profesores, que simulan en aula escenarios de la realidad a investigar.   - El desarrollo de competencias y aptitudes del Doctor en ciencias.   - La calidad se logra con la interdisciplinaridad e interinstitucionalidad nacional.   Los resultados principales han sido: a graduar investigadores con grado de Doctor en Ciencias en un tiempo promedio de 4 años; b el incremento de eficiencia terminal ha sido del 275%, de julio de 1995 a agosto de 2003 se han graduado 46 doctores. Esta autoevaluación del programa de doctorado proporciona evidencias de la contribución a la generación de un nuevo paradigma de

  12. PROMOTIONAL STRATEGY OF THE ALBA IULIA FORTRESS

    OpenAIRE

    Andreea Muntean; Lucian Marina

    2008-01-01

    The specific character of The Fortress of Alba Iulia results from its value as anelement of historical and cultural patrimony. This value must be kept and brought into prominence,and for this it must be promoted with the help of cultural tourism. This paper presents some issuesregarding the promotional strategy of the Alba Iulia Fortress.

  13. SÍNDROME DE BURNOUT EN ALUMNOS DE DOCTORADO EN EDUCACIÓN DE LA CIUDAD DE DURANGO

    OpenAIRE

    Arturo Barraza Macías; Flavio Ortega Muñoz; Manuel Ortega Muñoz

    2013-01-01

    Los objetivos de la presente investigación fueron identificar el perfil descriptivo del síndrome de burnout y establecer la relación que existe entre dicho síndrome y las variables sociodemográficas y situacionales estudiadas. Para el logro de tales propósitos, se realizó una investigación correlacional, transversal y no experimental a través de la aplicación de la Escala Unidimensional de Burnout Estudiantil a los alumnos de los dos doctorados en educación que existen en la ciudad de Durango...

  14. LGBTQ Experiences in Curricular Contexts

    Science.gov (United States)

    Linley, Jodi L.; Nguyen, David J.

    2015-01-01

    This chapter examines curricula as important microsystems for LGBTQ college students. The authors explore sociocultural influences on curricula and discuss strategies for creating positive curricular experiences for LGBTQ students.

  15. Geologic Mapping Investigations of Alba Mons, Mars

    Science.gov (United States)

    Crown, D. A.; Berman, D. C.; Scheidt, S. P.; Hauber, E.

    2018-06-01

    Geologic mapping of the summit region and western flank of Alba Mons at 1:1M-scale is revealing sequences of volcanic, tectonic, impact, and degradation processes that have formed and modified the northernmost of the Tharsis volcanoes.

  16. Using Alba Emoting™ to work with emotions in psychotherapy.

    Science.gov (United States)

    Kalawski, Juan Pablo

    2013-01-01

    Alba Emoting™ is a physical method to help recognize, induce, express and regulate the basic emotions. This is achieved through specific breathing, postural and facial behaviours. Alba Emoting is based on psychophysiological research by Susana Bloch and her collaborators, who have applied this method mainly to train actors. Alba Emoting can be used in psychotherapy to facilitate emotion awareness, regulation and transformation. It can also help therapists better recognize their own and their clients' emotions. The application of Alba Emoting in psychotherapy is illustrated with a case example. Alba Emoting is a physical, scientific method for working with emotions. Alba Emoting can help therapists better recognize their own and their clients' emotions. Alba Emoting can help clients achieve better emotional awareness and regulation. Alba Emoting can also help clients experience and express emotions they may normally inhibit. Copyright © 2011 John Wiley & Sons, Ltd.

  17. Integración curricular

    Directory of Open Access Journals (Sweden)

    Jesús F. Escanero Marcén

    Full Text Available Uno de los objetivos del Proceso de Bolonia de adaptación al Espacio Europeo de Educación Superior, es elaborar curricula basados en competencias. En este contexto, se plantea la conveniencia de adoptar modelos curriculares integrados. El artículo hace una revisión histórica de las experiencias de integración curricular llevadas a cabo a nivel internacional y español. En este último casose analizan dos documentos clave, la Declaración de Granada y el Libro Blanco de la Conferencia Nacional de Decanos de Medicina que abogan claramente por la integración curricular. Tras discutir las razones para la integración se describen las diferentes etapas a seguir en un proceso de integración de acuerdo con el modelo de Harden.

  18. Polygenic eruptions on Alba Patera, Mars

    International Nuclear Information System (INIS)

    Mouginis-Mark, P.J.; Wilson, L.; Zimbelman, J.R.

    1988-01-01

    A new model for the evolution of the martian volcano Alba Patera is constructed. Numerous digitate channel networks on the flanks of the volcano are interpreted to be carved by sapping due to the release of nonjuvenile water from unconsolidated flank deposits. The particle size of these deposits is estimated to be 3-10 microns, which, together with theoretical modelling of the disperison of explosively derived volcanic materials, leads to the conclusion that the flank deposits on Alba Patera are low-relief pyroclastic flows. The recognition of numerous late-stage summit and subterminal lava flows thus makes Alba Patera a unique martian volcano that is transitional between the older pyroclastic-dominated highland paterae and the more recent effusive central-vent volcanoes such as the Tharsis Montes. 61 refs

  19. Retention-Oriented Curricular Design

    Science.gov (United States)

    Milanovic, Ivana; Eppes, Tom A.; Girouard, Janice; Townsend, Lee

    2010-01-01

    This paper presents a retention-oriented approach to the educational value stream within the STEM undergraduate area. Faced with several strategic challenges and opportunities, a Flex Advantage Plan was developed to enhance the undergraduate engineering technology programs and better utilize the curricular flexibilities inherent in the current…

  20. Historia de las Prácticas Curriculares en los procesos de formación de licenciados: 1973-1998

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    Reynaldo Mora Mora

    2015-10-01

    Full Text Available Se presenta un resumen del trabajo final de tesis de doctorado en ciencias de la educación, titulada “Historia de las Prácticas Curriculares en los procesos de formación de licenciados en ciencias sociales: 1973-1998”. En esta investigación se da a conocer cómo se formaron licenciados y qué tipo de prácticas curriculares fueron puestas en escena por parte de las instituciones educativas del estudio. AbstractAn abstract of the of the final work of the doctoral thesis on Sciences of Education is presented under the title “A History of the Curricular Practices in the Process of Formation of Education Graduates in Social Sciences: 1973-1998”. In this research it is announced how the Education Graduates were educated and what sort of curricular practices were staged by the educational institutions studied.

  1. Two new prenylflavonoids from Morus alba.

    Science.gov (United States)

    Gao, Li; Li, Yuan-Dong; Zhu, Bao-Kun; Li, Zhi-Yu; Huang, Li-Bin; Li, Xian-Yi; Wang, Fei; Ren, Fu-Cai; Liao, Tou-Gen

    2018-02-01

    Two new prenylflavonoids, morusalbols A and B (1 and 2), were isolated from the branches and leaves of Morus alba, together with three known compounds, kuwanon C (3), morusin (4), morusinol (5). The structures of these two prenylflavonoids were elucidated by extensive analyzes of the spectroscopic data.

  2. Heartwood extractives of iranian morus alba wood

    International Nuclear Information System (INIS)

    Sadeghifar, H.; Sheikh, A.; Khalilzadeh, M.A.; Ebadi, A.G.

    2011-01-01

    The composition and amount of hydrophilic and lipophilic extractives in heartwood of Morus alba wood in north of Iran were analysed n-Decane (50%), dodecane (9%) and limonene (11%) were main lipophilic components. Resorcinol (about 90%) is main hydrophilic phenolic compound. (author)

  3. Sobre la formación universitaria del farmacéutico en el Postgrado y Doctorado

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    Mariño EL.

    2012-09-01

    Full Text Available Se pretende con esta publicación clarificar la situación de acceso a los programas de doctorado a los actuales egresados de Farmacia con la nueva titulación de Graduados, dado que, al menos en este tema para ellos, la normativa de hace más de un año es extraordinariamente clara, a diferencia de las opiniones sobre lo que quizás pueda llegar a pasar en otras cuestiones y muy especialmente en lo referente a las conocidas como “competencias”, su certificación ya permite la libre circulación de profesionales en el espacio europeo. Para su mejor comprensión se hace un breve y reciente recorrido de cómo se ha ido modificando, desde no hace mucho tiempo, todo lo relacionado con la realización de la Tesis Doctoral por parte del farmacéutico en general y con el asistencial en particular, partiendo siempre de la premisa de la conveniencia en la facilitación de la consecución de éste que es la mayor de las titulaciones universitarias.

  4. Doctorados con Mención de Excelencia en Psicología: evidencia en tesis doctorales y artículos en la Web of Science

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    José Alonso Olivas-Ávila

    2012-01-01

    Full Text Available Los programas de doctorado en España han experimentado una serie de transformaciones a través de las distintas convocatorias de Mención de Calidad y más recientemente con la Mención de Excelencia en función de lograr una satisfactoria adaptación al EEES. El objetivo de este estudio es realizar un análisis de la productividad científica de los cinco programas de doctorado en Psicología que les ha sido otorgada la Mención de Excelencia según la resolución de 6 de octubre de 2011 de la Secretaría General de Universidades, a través de las tesis doctorales dirigidas por los profesores de cada programa y recuperadas desde TESEO y también por medio de los artículos publicados en revistas incluidas en el Web of Science de cada uno de ellos. Los resultados del análisis de la productividad en artículos se obtuvieron tras analizar 15.781 artículos de los cuales 1.318 pertenecen al total de profesores de los 5 programas de doctorado. Se encontró que el rango de artículos por profesor es de 15,34 como máximo y 6 como mínimo, y en cuanto a las tesis el rango es entre 2,34 y 0,11. Se discuten las implicaciones de los resultados en cuanto a evaluación de los programas de doctorado.

  5. Geomorphology and stratigraphy of Alba Patera, Mars

    Science.gov (United States)

    Schneeberger, Dale M.; Pieri, David C.

    1991-01-01

    Geomorphic and stratigraphic analysis of Alba Patera suggests a volcanic construct built by lavas with rheologic properties similar to basalts. A series of evolving eruptive styles is suggested by changes in morphology and inferred progressive reductions in flow volume with higher stratigraphic position. Alba Patera's volcanic history has been summarized into four main phases. The first is characterized by extensive flood like flows presumably erupted from fissures associated with the initial intrusion of magma into the region. The second phase is associated with the emplacement of pyroclastic rock, a more speculative interpretation. The third phase produced the voluminous tabular, crested, and undifferentiated flows, probably from a more centralized vent source. The fourth and last phase is marked the effusion of levee like flows and the collapse of the summit calderas and final graben formation.

  6. Custom sample environments at the ALBA XPEEM

    Energy Technology Data Exchange (ETDEWEB)

    Foerster, Michael, E-mail: mfoerster@cells.es; Prat, Jordi; Massana, Valenti; Gonzalez, Nahikari; Fontsere, Abel; Molas, Bernat; Matilla, Oscar; Pellegrin, Eric; Aballe, Lucia

    2016-12-15

    A variety of custom-built sample holders offer users a wide range of non-standard measurements at the ALBA synchrotron PhotoEmission Electron Microscope (PEEM) experimental station. Some of the salient features are: an ultrahigh vacuum (UHV) suitcase compatible with many offline deposition and characterization systems, built-in electromagnets for uni- or biaxial in-plane (IP) and out-of-plane (OOP) fields, as well as the combination of magnetic fields with electric fields or current injection. Electronics providing a synchronized sinusoidal signal for sample excitation enable time-resolved measurements at the 500 MHz storage ring RF frequency. - Highlights: • Custom sample environment for XPEEM at ALBA. • Sample holders with electromagnets, in-plane dipole, in-plane quadruple and out-of-plane. • Sample holders with printed circuit boards for electric contacts including electromagnets. • UHV suitcase adapter. • Synchronized 500 MHz electrical excitation for time resolved measurements.

  7. curricular innovation in the university

    Directory of Open Access Journals (Sweden)

    María Mercedes Callejas Restrepo

    2013-07-01

    Full Text Available The 21st century sets out new challenges to universities and university professors,who have to debate on the quality of education, the requirements on the teaching and learning, and the proposed curricula for the professional and disciplinary training in the university. In this context, research groups from four Colombian universities have developed a project in order to articulate therelationshipswithin the training of university professors, through the research of their practices and processes of curricular innovation. With such a goal the conformation of pedagogical collectives is promoted, and a reflective process about their pedagogical styles is generated (Callejas&,Corredor, 2002. Action research as a methodology and strategy of professional evelopment is proposed (McKernan, 1999, observation-reflection, planning-action, and then back to observation-reflection.Video recordings of classes, individual and group observation of the recordings, and individual and group interviews that favor reflection processes about the dimensions of the pedagogical style are performed. The analysis of the practice is guided by a complex, investigative and comprehensive vision of the curriculum that articulates theory and practice. The critical recognition that teachers do about their own pedagogical style favors the evolution of their ideas and guides them to start a process of curricular innovation.

  8. Uniaxial and biaxial mechanical properties of porcine linea alba

    NARCIS (Netherlands)

    Cooney, Gerard M.; Moerman, Kevin M.; Takaza, Michael; Winter, Des C.; Simms, Ciaran K.

    2015-01-01

    Incisional hernia is a severe complication post-laparoscopic/laparotomy surgery that is commonly associated with the linea alba. However, the few studies on the mechanical properties of the linea alba in the literature appear contradictory, possible due to challenges with the physical dimensions of

  9. Gestión comunicacional de la agenda de internacionalización de los doctorados de la Universidad del Zulia

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    Mary Ollarves

    2012-05-01

    Full Text Available En la presente investigación el objetivo general fue determinar la gestión comunicacional de la agenda de internacionalización de los doctorados de la Universidad del Zulia, en las divisiones de estudios para graduados de las Facultades Ciencias Jurídicas y Políticas, Ciencias Económicas y Sociales y Humanidades y Educación. Se destacan los aportes de los autores Ramírez (2005, Serna (2000, Monzón (2001, Wimmer y Dominick (2001, Rivera (2008, Otegui (2008, Núñez (2008, Trejo (2001; Gacel-ávila (2000, García (2001, Jaramillo y De Lisio (2004, entre otros. El estudio es de tipo cuantitativoy se utilizó como técnica la entrevista semi estructurada dirigida a los directores de: Relaciones Interinstitucionales, General de Comunicación, Divisiones de Estudios para Graduados y Coordinadores de los programas de doctorados, todos de la Universidad del Zulia. La investigación propone integrar la gestión comunicacionala la agenda académica,para promocionar la política de internacionalización de los doctorados de la Universidad del Zulia en el marco de los convenios interinstitucionales. Los resultados demostraron que ciertamente, existe una debilidad en los principios básicos organizacionales y poco interés por proyectar una imagen corporativa, aunque se han hecho adelantos significativos desde la dirección de Relaciones Interinstitucionales y la División de Estudios para Graduados de la Facultad de Humanidades y Educación para posicionarse mundialmente en el área.

  10. El doctorado en urbanismo: la revisión de un programa maduro para la preservación del conocimiento libre

    OpenAIRE

    Sevilla Buitrago, Álvaro; Hernández Aja, Agustín

    2009-01-01

    Los conflictos en la definición del doctorado en urbanismo, que emergen con la integración al EEES, tienen relación con la dificultad de sintetizar los métodos y marcos de planeamiento locales con la vocación de estandarización a nivel europeo. Esta búsqueda choca con la realidad local de cada centro y universidad y sobre todo con la especificidad de una disciplina compleja y multidimensional como la urbanística. Las universidades están exigiendo a sus centros adaptarse a un patrón investigad...

  11. The Alba ray tracing code: ART

    Science.gov (United States)

    Nicolas, Josep; Barla, Alessandro; Juanhuix, Jordi

    2013-09-01

    The Alba ray tracing code (ART) is a suite of Matlab functions and tools for the ray tracing simulation of x-ray beamlines. The code is structured in different layers, which allow its usage as part of optimization routines as well as an easy control from a graphical user interface. Additional tools for slope error handling and for grating efficiency calculations are also included. Generic characteristics of ART include the accumulation of rays to improve statistics without memory limitations, and still providing normalized values of flux and resolution in physically meaningful units.

  12. In vitro regeneration of Basella alba L

    Science.gov (United States)

    Edney, Norris Allen; Rizvi, Muhammad A.; Rizvi, Narjis F.

    1989-01-01

    Basella alba L. is a tropical vine used as a vegetable in some Asian and African countries. It has potential as a nontraditional crop for small family farms. A short day plant, it blooms during the fall, provided the temperatures are mild. In the southeastern U.S., the short days of fall are associated with subfreezing temperatures, and plants are killed before blooming. Attempts were made to regenerate the plant using tissue culture techniques. Several trials were conducted with different media, hormones, and explants. It was found that nodal segments on Gamborg medium regenerated shoots. Interaction studies of auxins and cytokinins indicated that its endogeneous auxin content might be high because callus proliferated in almost all treatments and roots initiated even when the medium was not supplemented with an auxin.

  13. Iglesia de San Casiano. Alba – Italia

    Directory of Open Access Journals (Sweden)

    Dellapiana, Ugo

    1978-08-01

    Full Text Available This church in Alba has been designed according to the guidelines issued by the Vatican II Council. The development of the interior planes and volumes correspond to the religious «signs» of the New Liturgy: baptistery, altar, pulpit, tabernacle, confessionals and choir, which shapes are also reflected in the outside. The correct lighting by means of skylights contribute decisively to create a high religious character and atmosphere in the whole. The construction of the church is based on reinforced concrete walls extended in a curvilinear shape which, at the same time they serve as interior partitions, bear the very elaborate roofing. The materials used in the construction and in the interior finishings, as well as the correct sequence of spaces, help to put in evidence the function of the different rooms and hails, while at the same time underline a high religious feeling.

    Esta iglesia ha sido construida en Alba según las directrices emanadas del Concilio Vaticano II. En ella, los «signos» religiosos de la Nueva Normativa Litúrgica —baptisterio, altar, púlpito, sagrario, confesionarios y coro— conforman el desarrollo planivolumétrico interior, quedando igualmente reflejados en la configuración externa. Al carácter o ambiente religioso contribuye también, de una manera decisiva, la adecuada iluminación de los lucernarios cenitales. Está construido a base de muros de hormigón armado que, con sus prolongaciones curvilíneas, organizan los espacios interiores al tiempo que sirven de elementos portantes de la compleja cubierta. Los materiales empleados en la construcción y los tratamientos interiores, así como la adecuada secuencia de ambientes, contribuyen a resaltar la funcionalidad de los distintos espacios procurando un carácter de marcada religiosidad.

  14. Segundo Concurso Latinoamericano de Novela Alba Narrativa 2011

    Directory of Open Access Journals (Sweden)

    Boletín Cultural y Bibliográfico Banco de la República

    2007-10-01

    Full Text Available El Fondo Cultural del Alba, a través del Centro Cultural Dulce María Loynaz, convoca al Segundo Concurso Latinoamericano de Novela Alba Narrativa 2011 , para autores menores de cuarenta años, con el propósito de estimular y promover a los jóvenes novelistas que escriben con una mirada latinoamericana y renovadora en los países de nuestra América.

  15. ANTIHEPATOTOXIC ACTIVITY OF ECLIPTA ALBA, TEPHROSIA PURPUREA AND BOERHAAVIA DIFFUSA

    Science.gov (United States)

    Murthy, V. N.; Reddy, B. Praveen; Venkateshwarlu, V.; Kokate, C. K.

    1992-01-01

    Alcoholic and chloroform extracts of E. alba T. purpurea and B. diffusa were screened for antihepatotoxic activity. The extracts were given after the liver was damaged with CCl4. Liver function was assessed based on liver to boy weight ratio, pentobarbitone sleep time, serum levels of transaminase (SGPT, SGOT), alkaline phosphatase (SALP) and bilirubin. Alcoholic extract of E. alba was found to have good antihepatotoxic activity. PMID:22556585

  16. Curricular improvements for entrepreneurial education

    Directory of Open Access Journals (Sweden)

    Vasilache Simona

    2017-07-01

    Full Text Available Our paper aims at investigating the most adequate methods for developing effective educational tools in entrepreneurial education. Entrepreneurship education should take place during the entire life of an entrepreneur, but the basic knowledge and skills related to this field are acquired starting from the elementary school, and improved during all the educational levels. Through entrepreneurship education, policymakers aim to prepare young people for succeeding on the entrepreneurial path. However, there are few scientific papers that aimed at discussing the available educational tools in Romania which play a role in forming entrepreneurs. Starting from the identified educational needs of young Romanian people under 35, including entrepreneurs and students, which were surveyed based on a questionnaire, we advance several key improvement areas for Romanian business curricula, and suggest critical paths to obtain desired results. The recommendations that we deliver through this paper are based on respondents’ opinions regarding their preference for certain aspects related to educational tools used in entrepreneurial education: learning materials used in universities in order to create an entrepreneurial mindset, the use of learning materials outside of the university curricula, and entrepreneurial skills that should be developed during school. A comparative perspective, examining curricular specificities in most entrepreneurial cultures of Europe, based on information obtained from Entrepreneurship Eurobarometer and Doing Business Indicators, is also included in our study. The main limitations, which arise from the subjective perspective of young entrepreneurs, as well as from the reduced sample volume, are thus corrected. The conclusions of our analysis provide a valuable starting point for educational policies promoting entrepreneurial skills enhancement in the Romanian business students’ population.

  17. Alba from Thermoplasma volcanium belongs to α-NAT's: An insight into the structural aspects of Tv Alba and its acetylation by Tv Ard1.

    Science.gov (United States)

    Ma, Chao; Pathak, Chinar; Lee, Sang Jae; Lee, Ki-Young; Jang, Sun-Bok; Nam, Minjoo; Im, Hookang; Yoon, Hye-Jin; Lee, Bong-Jin

    2016-01-15

    The Alba superfamily proteins have been regarded as a conserved group of proteins in archaea and eukarya, which have shown to be important in nucleic acid binding, chromatic organization and gene regulation. These proteins often belong to the N-acetyltransferase (NAT) category (N(α)-acetyltransferases or N(ε)-acetyltransferases) and undergo post-translational modifications. Here, we report the crystal structure of Alba from Thermoplasma volcanium (Tv Alba) at 2.4 Å resolution. The acetylation of Tv Alba was monitored and the N-terminal of Tv Alba has been shown to interact with acetyl coenzyme A (Ac-CoA). The chemical shift perturbation experiments of Tv Alba were performed in the presence of Ac-CoA and/or Tv Ard1, another T. volcanium protein that treats Tv Alba as a substrate. To examine the DNA binding capabilities of Tv Alba alone and in the presence of Ac-CoA and/or Tv Ard1, EMSA experiments were carried out. It is shown that although Tv Alba binds to Ac-CoA, the acetylation of Tv Alba is not related with its binding to dsDNA, and the involvement of the N-terminus in Ac-CoA binding demonstrates that Tv Alba belongs to the N(α)-acetyltransferase family. Copyright © 2015 Elsevier Inc. All rights reserved.

  18. Enfoque curricular centrado en la persona

    Directory of Open Access Journals (Sweden)

    Luis Manuel Jiménez Castro

    2008-01-01

    Full Text Available Un enfoque curricular estructura, visua-liza y organiza el proceso educativo. Sin embargo, a pesar de su importancia, el sistema educativo costa-rricense no identifica unas características prácticas claras de un enfoque curricular, por medio del cual el educador pueda ubicar el tipo de estudiante que debe formar.Se desea sistematizar y aportar por medio de una revisión bibliográfica, del enfoque curricular cen-trado en la persona, una alternativa que favorezca la formación de las personas de manera integral, que promueva la crítica, la búsqueda de soluciones a problemas comunales y en general al avance de la sociedad a través del bien común.

  19. Strategi Venezuela Menyepakati ALBA dalam Menghadapi Ekspansi Perdagangan Amerika Serikat Dikawasan Amerika Latin

    OpenAIRE

    Pahlawan, Indra; Wahyu, Septian

    2014-01-01

    In 2004 Venezuela and Cuba have agreed on a regional collaboration in latin america called Alternative Bolivarian Para las Americas an abbreviated ALBA. This collaboration is formed as a resistance facing U.S. trade expansion to bring a mission neoliberalism. With the formation of ALBA, Venezuela is the regional co-operation leaders make strategic measures to face Neoliberalism. In 2010 ALBA has had a total of 10 member countries. As counter hegemony, ALBA also worked in three space. In the s...

  20. Curricular Management of the Internet: Beyond the Blocking Solution.

    Science.gov (United States)

    Lynch, Paul J.

    2000-01-01

    Focuses on managed Internet use as a curricular challenge and alternate solution to blocking software. Suggests that by making curricular choices for students and directing the medium towards curricular goals, teachers can manage students' time and provide a safe environment where students can communicate and collaborate on projects. (AEF)

  1. Potency of Mangrove Apple (Sonneratia alba as Mercury Bioindicator

    Directory of Open Access Journals (Sweden)

    Muhammad Reza Cordova

    2017-12-01

    Full Text Available The anthropogenic provide a negative impact on the surrounding environment. Mangrove species, such as Sonneratia alba would get the impact of anthropogenic activities, to accumulate the pollution of heavy metals. The aim of this study were to evaluate mercury accumulation in Mangrove Apple (S. alba and to analyze mangrove apple potency as mercury bioindicator. Samples were taken in April 2016 at Pari Island, Seribu Islands by purposive sampling. The results showed that the highest concentration of Hg in the Northern of Pari Island was found in the leaves and the lowest was in the fruit. The highest concentration of Hg in the Eastern of Pari Island was found in the leaves and lowest was in the fruit. The concentrations of Hg in the Eastern area higher the Northern area (significantly different. The accumulation of Hg mainly collected on the leaves with TF> 1, but the ability of S. alba trees absorb Hg in the environment showed a small value, namely BCF <1. The ability of S. alba in sediments, contaminated with mercury showed a high value of the leaves in the East Pari Island, but the fruit of S. alba both in the North and East of the Pari Island showed a small value.  Mangrove Apple leaves has a potency as mercury bioindicator organ.

  2. Curricular Guidelines for Dental Auxiliary Radiology.

    Science.gov (United States)

    Journal of Dental Education, 1981

    1981-01-01

    AADS curricular guidelines suggest objectives for these areas of dental auxiliary radiology: physical principles of X-radiation in dentistry, related radiobiological concepts, principles of radiologic health, radiographic technique, x-ray films and intensifying screens, factors contributing to film quality, darkroom, and normal variations in…

  3. Curricular Content for Pupils' Mental Health

    Science.gov (United States)

    Ebadi, Seyed Hossein; Keshtiaray, Narges; Aghaei, Asghar; Yousefy, Alireza

    2016-01-01

    Present-day curricular designs have to take the pupils' psychological needs in account, thus becoming melodies of mental health and happiness for the next generation. Emphasizing the findings from previous investigations using the research synthesis methodology, the present study has been conducted aiming at achieving some integrative knowledge…

  4. A Total Curricular Approach to Environmental Education

    Science.gov (United States)

    Jinks, Jerry L.

    1975-01-01

    Presented is an environmental education model based on an interdisciplinary curricular structure. The model consists of three two-dimensional matrices organizing objectives, strategies, and content. Each matrix lists environmental concepts along one axis and the disciplines along the other. One interpretation of the model is presented as a…

  5. Curricular Change: A Model for Analysis.

    Science.gov (United States)

    Axelrod, Joseph

    This interim report on 1 project at the Berkeley Center for Research and Development in Higher Education deals with the construction of a theoretical model of the curricular-instructional subsystem. The relationship between student unrest and the poor quality of education in American colleges has long been evident to educational researchers. The…

  6. New Microsatellite Loci for Prosopis alba and P. chilensis (Fabaceae

    Directory of Open Access Journals (Sweden)

    Cecilia F. Bessega

    2013-05-01

    Full Text Available Premise of the study: As only six useful microsatellite loci that exhibit broad cross-amplification are so far available for Prosopis species, it is necessary to develop a larger number of codominant markers for population genetic studies. Simple sequence repeat (SSR markers obtained for Prosopis species from a 454 pyrosequencing run were optimized and characterized for studies in P. alba and P. chilensis. Methods and Results: Twelve markers that were successfully amplified showed polymorphism in P. alba and P. chilensis. The number of alleles per locus ranged between two and seven and heterozygosity estimates ranged from 0.2 to 0.8. Most of these loci cross-amplify in P. ruscifolia, P. flexuosa, P. kuntzei, P. glandulosa, and P. pallida. Conclusions: These loci will enable genetic diversity studies of P. alba and P. chilensis and contribute to fine-scale population structure, indirect estimation of relatedness among individuals, and marker-assisted selection.

  7. New microsatellite loci for Prosopis alba and P. chilensis (Fabaceae).

    Science.gov (United States)

    Bessega, Cecilia F; Pometti, Carolina L; Miller, Joe T; Watts, Richard; Saidman, Beatriz O; Vilardi, Juan C

    2013-05-01

    As only six useful microsatellite loci that exhibit broad cross-amplification are so far available for Prosopis species, it is necessary to develop a larger number of codominant markers for population genetic studies. Simple sequence repeat (SSR) markers obtained for Prosopis species from a 454 pyrosequencing run were optimized and characterized for studies in P. alba and P. chilensis. • Twelve markers that were successfully amplified showed polymorphism in P. alba and P. chilensis. The number of alleles per locus ranged between two and seven and heterozygosity estimates ranged from 0.2 to 0.8. Most of these loci cross-amplify in P. ruscifolia, P. flexuosa, P. kuntzei, P. glandulosa, and P. pallida. • These loci will enable genetic diversity studies of P. alba and P. chilensis and contribute to fine-scale population structure, indirect estimation of relatedness among individuals, and marker-assisted selection.

  8. Allozyme diversity in Macbridea alba (Lamiaceae), an endemic Florida mint

    Science.gov (United States)

    M.J.W. Godt; Joan L. Walker; J.L. Hamrick

    2004-01-01

    Macbridea alba is a herbaceous perennial mint endemic to the panhandle region of Florida. We used starch gel electrophoresis to describe allozyme diversity and genetic structure in this federally threatened plant. Ten populations were analyzed, with an average sample size of 47 plants (range 41-48 plants) per population. Of the 22 loci analyzed, 11 (...

  9. Onion and weed response to mustard (Sinapis alba) seed meal

    Science.gov (United States)

    Weed control in organic onion production is often difficult and expensive, requiring numerous cultivations and extensive hand-weeding. Onion safety and weed control with mustard seed meal (MSM) derived from Sinapis alba was evaluated in greenhouse and field trials. MSM applied at 110, 220, and 440 g...

  10. ECONOMIC CRISIS IMPACT ON COUNTY ALBA HOTEL INDUSTRY

    Directory of Open Access Journals (Sweden)

    MOISA Claudia Olimpia

    2012-12-01

    Full Text Available The present paper, dominated by the global economic crisis effects is and continues to be a critical time for global tourism industry and for Romanian too. This study tries to play on a particular case, Park Hotel, located in Alba Iulia, the impact of this phenomenon over tourist hotel services.

  11. ECONOMIC CRISIS IMPACT ON COUNTY ALBA HOTEL INDUSTRY

    OpenAIRE

    MOISA Claudia Olimpia

    2012-01-01

    The present paper, dominated by the global economic crisis effects is and continues to be a critical time for global tourism industry and for Romanian too. This study tries to play on a particular case, Park Hotel, located in Alba Iulia, the impact of this phenomenon over tourist hotel services.

  12. Phytochemistry, pharmacology, and clinical trials of Morus alba.

    Science.gov (United States)

    Chan, Eric Wei-Chiang; Lye, Phui-Yan; Wong, Siu-Kuin

    2016-01-01

    The present review is aimed at providing a comprehensive summary on the botany, utility, phytochemistry, pharmacology, and clinical trials of Morus alba (mulberry or sang shu). The mulberry foliage has remained the primary food for silkworms for centuries. Its leaves have also been used as animal feed for livestock and its fruits have been made into a variety of food products. With flavonoids as major constituents, mulberry leaves possess various biological activities, including antioxidant, antimicrobial, skin-whitening, cytotoxic, anti-diabetic, glucosidase inhibition, anti-hyperlipidemic, anti-atherosclerotic, anti-obesity, cardioprotective, and cognitive enhancement activities. Rich in anthocyanins and alkaloids, mulberry fruits have pharmacological properties, such as antioxidant, anti-diabetic, anti-atherosclerotic, anti-obesity, and hepatoprotective activities. The root bark of mulberry, containing flavonoids, alkaloids and stilbenoids, has antimicrobial, skin-whitening, cytotoxic, anti-inflammatory, and anti-hyperlipidemic properties. Other pharmacological properties of M. alba include anti-platelet, anxiolytic, anti-asthmatic, anthelmintic, antidepressant, cardioprotective, and immunomodulatory activities. Clinical trials on the efficiency of M. alba extracts in reducing blood glucose and cholesterol levels and enhancing cognitive ability have been conducted. The phytochemistry and pharmacology of the different parts of the mulberry tree confer its traditional and current uses as fodder, food, cosmetics, and medicine. Overall, M. alba is a multi-functional plant with promising medicinal properties. Copyright © 2016 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

  13. Three new alkaloids from the fruits of Morus alba.

    Science.gov (United States)

    Wang, Xin; Kang, Jie; Wang, Hong-Qing; Liu, Chao; Li, Bao-Ming; Chen, Ruo-Yun

    2014-01-01

    From the fruits of Morus alba, three new alkaloids, mulbaines A (1), B (2), and C (3) were isolated. The structures of these compounds were elucidated on the basis of spectroscopic methods (UV, IR, HR-ESI-MS, 1D, and 2D NMR).

  14. Macrophage activating activity of pyrrole alkaloids from Morus alba fruits.

    Science.gov (United States)

    Kim, Seon Beom; Chang, Bo Yoon; Jo, Yang Hee; Lee, Sang Hoon; Han, Sang-Bae; Hwang, Bang Yeon; Kim, Sung Yeon; Lee, Mi Kyeong

    2013-01-09

    The fruits of Morus alba have been traditionally used as a tonic to enhance immune responses. The macrophage activating constituents of Morus alba fruits were purified using various column chromatography techniques. The structures of isolated compounds were determined on the basis of spectroscopic data interpretation such as 1D and 2D NMR analysis. The macrophage activating activities of isolated compounds were evaluated by measuring the production of nitric oxide, TNF-α and IL-12 in RAW 264.7 cells. The phagocytic activity was also evaluated. Five pyrrole alkaloids, 5-(hydroxymethyl)-1H-pyrrole-2-carboxaldehyde (1), 2-formyl-1H-pyrrole-1-butanoic acid (2), 2-formyl-5-(hydroxymethyl)-1H-pyrrole-1-butanoic acid (3), 2-formyl-5-(methoxymethyl)-1H-pyrrole-1-butanoic acid (4) and Morrole A (5) were isolated from the fruits of Morus alba. Morrole A (5) is first reported in nature and other pyrrole alkaloids (1-4) are first reported from Morus species. Among the isolated compounds, compounds 3 and 4 significantly activated macrophage activity by the enhancement of nitric oxide, TNF-α and IL-12 production, and the stimulation of phagocytic activity in RAW 264.7 cells. Pyrrole alkaloids, including a new compound, were isolated from Morus alba fruits. These compounds activated macrophage activity in RAW 264.7 cells. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  15. Peptides extracted from Artemisia herba alba have antimicrobial ...

    African Journals Online (AJOL)

    Background: Artemisia herba alba, classified into the family of Asteraceae, is an aromatic herb that is traditionally used as a purgative and antipyretic folk medicine by rural people of south Tunisia. This study reports the first identification of antimicrobial peptides from this medicinal plant that inhibited the growth of several ...

  16. Antidiabetic effect of aqueous extract of Basella alba leaves and ...

    African Journals Online (AJOL)

    Group V rats were also induced with diabetes and treated with Metformin at a dose of 100 mg/kg body weight. The various treatments were administered orally for a period of three weeks. The mean fasting blood glucose (FBG) of the rats was determined weekly using a glucometer. The rats treated with B. alba at doses of ...

  17. Antidiabetic Activity of Plumeria Alba Linn (Apocynaceae) Root ...

    African Journals Online (AJOL)

    Fructose-enriched fat diet increased blood cholesterol, triglycerides and high density lipoprotein (HDL) levels in hyperlipidemic untreated rats compared to normal control rats. Administration of total extract (250 mg/kg/day) and supernatant fraction of P. alba (100 mg/kg/day) during 14 days significantly reduced lipid ...

  18. Evaluation of allelopathic effect of Eclipta alba (L.) Hassk on ...

    African Journals Online (AJOL)

    A study was conducted to assess the magnitude of suppressing ability of Eclipta alba (L.) Hassk. on some selected weeds of Aligarh namely, Amaranthus spinosus L., Cassia tora L. and Cassia sophera L. The research finding was conducted to evaluate the effect of aqueous leaf leachate and organic fractions of donor plant ...

  19. Chemical composition and antigenotoxic properties of Lippia alba essential oils

    Directory of Open Access Journals (Sweden)

    Molkary Andrea López

    2011-01-01

    Full Text Available The present work evaluated the chemical composition and the DNA protective effect of the essential oils (EOs from Lippia alba against bleomycin-induced genotoxicity. EO constituents were determined by Gas Chromatography/Mass Spectrometric (GC-MS analysis. The major compounds encountered being citral (33% geranial and 25% neral, geraniol (7% and trans-β-caryophyllene (7% for L. alba specimen COL512077, and carvone (38%, limonene (33% and bicyclosesquiphellandrene (8% for the other, COL512078. The genotoxicity and antigenotoxicity of EO and the compounds citral, carvone and limonene, were assayed using the SOS Chromotest in Escherichia coli. The EOs were not genotoxic in the SOS chromotest, but one of the major compound (limonene showed genotoxicity at doses between 97 and 1549 mM. Both EOs protected bacterial cells against bleomycin-induced genotoxicity. Antigenotoxicity in the two L. alba chemotypes was related to the major compounds, citral and carvone, respectively. The results were discussed in relation to the chemopreventive potential of L. alba EOs and its major compounds.

  20. CURRICULAR OFFER INFLUENCING STUDENTS’ SATISFACTION: COMPARATIVE STUDY

    Directory of Open Access Journals (Sweden)

    Oana DUMITRASCU

    2014-11-01

    Full Text Available The main objective of the study is the determination of students’ satisfaction regarding curricular activities. The study has been accomplished using the qualitative and quantitative research, using the bibliographic study, various secondary sources and different primary sources. The study is developed with a marketing research and accomplished using the survey method. 699 students from four universities have been questioned. Due to a comparative study the University of Applied Sciences Worms, University of Applied Sciences Wiesbaden Rüsselsheim, University of Applied Sciences Frankfurt am Main and Nürtingen-Geislingen University have been analysed and their similarities and differences have been identified. The collected data, based on the established sample, is evaluated through univariate and bivariate analysis. In accordance with the evaluated sample, specific gaps from each region are identified regarding the curricular offer of the analysed universities. As a result to the conducted study, recommendations for the University of Applied Sciences Worms regarding the student’s satisfaction concerning the curricular offer are presented.

  1. Amanitin and phallotoxin concentration in Amanita phalloides var. alba mushroom.

    Science.gov (United States)

    Kaya, Ertugrul; Yilmaz, Ismail; Sinirlioglu, Zeynep Aydin; Karahan, Selim; Bayram, Recep; Yaykasli, Kursat Oguz; Colakoglu, Serdar; Saritas, Ayhan; Severoglu, Zeki

    2013-12-15

    Although rarely seen, Amanita phalloides var. alba, a variety of A. phalloides type mushrooms, causes mushroom poisoning resulting in death. Since it is frequently confused with some edible mushrooms due to its white colored cap and macroscopic appearance, it becomes important in toxicological terms. Knowledge of the toxin amount contained in this mushroom type is invaluable in the treatment of cases involving poisoning. In this study, we examined the toxin levels of various parts of the A. phalloides var. alba mushroom growing Duzce region of Turkey. Toxin analyses were carried out for A. phalloides var. alba, which were collected from the forests Duzce region of Turkey in 2011, as a whole and also separately in its spore, pileus, gills, stipe and volva parts. The alpha amanitin, beta amanitin, gamma amanitin, phalloidin and phallacidine analyses of the mushrooms were carried out using the RP-HPLC method. A genetic analysis of the mushroom showed that it had similar genetic characteristics as A. phalloides and was a variety of it. The lowest toxins quantity was detected in spores, volva and stipe among all parts of the mushroom. The maximum amount of amatoxins was measured in the gills. The pileus also contained a high amount of amatoxins. Generally, amatoxins and phallotoxin concentrations were lower as compared to A. phalloides, but interestingly all toxins other than gamma toxin were higher in the spores of A. phalloides var. alba. The amount of toxin in all of its parts had sufficient concentrations to cause death. With this study, the amatoxin and phallotoxin concentrations in A. phalloides var. alba mushroom and in its parts have been revealed in detail for the first time. Copyright © 2013 Elsevier Ltd. All rights reserved.

  2. Conceptualising Curricular Space in Busyness Education

    DEFF Research Database (Denmark)

    Blasco, Maribel

    2016-01-01

    This article outlines a conceptual framework for conceptualising students’ experiences of curricular space from an aesthetic perspective. The curriculum is conceived as a three-dimensional, aesthetic artefact that elicits sensory responses and judgements about meaning that can impact learning. Sp...... and creative thinking. The Japanese concept of ma is proposed as a fruitful way of thinking about space in curricula not as wasteful, inefficient or a mere void to be filled but as the element that enables learning to result from exposing students to structures and content...

  3. Relative ages of lava flows at Alba Patera, Mars

    International Nuclear Information System (INIS)

    Schneeberger, D.M.; Pieri, D.C.

    1987-01-01

    Many large lava flows on the flanks of Alba Patera are astonishing in their volume and length. As a suite, these flows suggest tremendously voluminous and sustained eruptions, and provide dimensional boundary conditions typically a factor of 100 larger than terrestrial flows. One of the most striking features associated with Alba Patera is the large, radially oriented lava flows that exhibit a variety of flow morphologies. These include sheet flows, tube fed and tube channel flows, and undifferentiated flows. Three groups of flows were studied; flows on the northwest flank, southeast flank, and the intracaldera region. The lava flows discussed probably were erupted as a group during the same major volcanic episode as suggested by the data presented. Absolute ages are poorly constrained for both the individual flows and shield, due in part to disagreement as to which absolute age curve is representative for Mars. A relative age sequence is implied but lacks precision due to the closeness of the size frequency curves

  4. Flavonoids from the flowers of Nymphaea alba L.

    Directory of Open Access Journals (Sweden)

    Jerzy Jambor

    2014-01-01

    Full Text Available Ten flavonoids were obtained from the flowers of Nymphaea alba L. Their structures were determined mainly on the basis of spectral analyses (UV, 'H NMR, MS. The following aglycons were isolated: quercetin, kaempferol, isokaempferide and apigenin as well as the following glycosides: quercetion 4'-β-xyloside, 3-methylquercetin 3'-β-xyloside and a mixture of quercetin 3-galactoside and 3-glucoside. The structures of three compounds obtained in very small amounts were determined in part.

  5. New 2-arylbenzofuran metabolite from cell cultures of Morus alba.

    Science.gov (United States)

    Zhang, De-Wu; Tao, Xiao-Yu; Yu, Li-Yan; Dai, Jun-Gui

    2015-01-01

    A new 2-arylbenzofuran compound, 5-dehydroxy-moracin U (1), along with 10 known compounds (2-11), were isolated from cell cultures of Morus alba. Their structures were elucidated on the basis of extensive spectroscopic analyses. The anti-inflammatory activity assay of 1-8 showed that 2 and 8 exhibited significant inhibitory effect on LPS-induced NO production with the values of 76.4% and 98.7% at 10(- 5) M, respectively.

  6. Chemical Diversity in Lippia alba (Mill.) N. E. Brown Germplasm

    OpenAIRE

    Arie Fitzgerald Blank; Lídia Cristina Alves Camêlo; Maria de Fátima Arrigoni-Blank; José Baldin Pinheiro; Thiago Matos Andrade; Edenilson dos Santos Niculau; Péricles Barreto Alves

    2015-01-01

    The aim of this study was to perform chemical characterization of Lippia alba accessions from the Active Germplasm Bank of the Federal University of Sergipe. A randomized block experimental design with two replications was applied. The analysis of the chemical composition of the essential oils was conducted using a gas chromatograph coupled to a mass spectrometer. The chemical composition of the essential oils allowed the accessions to be allocated to the following six groups: group 1: linalo...

  7. Preservice Teachers' Belief Systems toward Curricular Outcomes for Physical Education

    Science.gov (United States)

    Kulinna, Pamela Hodges; Brusseau, Timothy; Ferry, Matthew; Cothran, Donetta

    2010-01-01

    This study was grounded in the belief systems and physical activity literature and investigated preservice teachers' belief systems toward curricular outcomes for physical education programs. Preservice teachers (N = 486; men = 62%, women = 38%) from 18 U.S. colleges/universities shared their beliefs about curricular outcomes. Preservice teachers…

  8. Curricular Deliberation about "Hamlet": An Exercise in the Practical.

    Science.gov (United States)

    Siegel, Judith Susan

    This study attempts to clarify and exploit Joseph Schwab's recent and current work on "practical" and "eclectic" curriculums in a simulated deliberation about a concrete curricular question, How might "Hamlet" be taught to one group of high school juniors? By exemplifying curricular deliberation, it aims to clarify…

  9. KINETICS OF ULTRASOUND ASSISTED EXTRACTION OF WEDELOLACTONE FROM Eclipta alba

    Directory of Open Access Journals (Sweden)

    T. W. Charpe

    Full Text Available Abstract Ultrasound assisted extraction of wedelolactone, a major coumestan present in Eclipta alba, is investigated in the present work.Various process parameters such as type of solvent, power, solvent to solid ratio and extraction temperature, which affect the extraction yield, are optimized. In the ultrasound-assisted extraction with final optimized conditions, i.e., methanol as solvent, 170 W power, 60:1 solvent to solid ratio, 50 °C temperature and 60% duty cycle, amaximum extraction yieldof 0.62 mg/g is obtained in 45 minutes. The kinetic model (Peleg's model has been used for the prediction of the yield of wedelolactone in the extract at a given time for all experimental conditions. The values of predicted yields show good agreement with the experimental data for all parameters, i.e., power, solvent to solid ratio and temperature. The extraction of wedelolactone from Eclipta alba is also carried out by conventional extraction methods, i.e., Soxhlet and batch extraction. Ultrasound-assisted extraction gives higher extraction yield in less time as compared to batch extraction (0.41 mg/g in 90 min and Soxhlet extraction(0.7 mg/g in 360 min. The ultrasound-assisted extraction of wedelolactone from Eclipta alba is an effective way of extraction with the advantages of lower time and higher extraction.

  10. A Chemical Investigation of the Leaves of Morus alba L.

    Science.gov (United States)

    Chen, Xiao-Yan; Zhang, Ting; Wang, Xin; Hamann, Mark T; Kang, Jie; Yu, De-Quan; Chen, Ruo-Yun

    2018-04-26

    The leaves of Morus alba L. are an important herbal medicine in Asia. The systematic isolation of the metabolites of the leaves of Morus alba L. was achieved using a combination of liquid chromatography techniques. The structures were elucidated by spectroscopic data analysis and the absolute configuration was determined based on electronic circular dichroism (ECD) spectroscopic data and hydrolysis experiments. Their biological activity was evaluated using different biological assays, such as the assessment of their capacity to inhibit the aldose reductase enzyme; the determination of their cytotoxic activity and the evaluation of their neuroprotective effects against the deprivation of serum or against the presence of nicouline. Chemical investigation of the leaves of Morus alba L. resulted in four new structures 1 ⁻ 4 and a known molecule 5 . Compounds 2 and 5 inhibited aldose reductase with IC 50 values of 4.33 μM and 6.0 μM compared with the potent AR inhibitor epalrestat (IC 50 1.88 × 10 −3 μM). Pretreatment with compound 3 decreased PC12 cell apoptosis subsequent serum deprivation condition and pretreatment with compound 5 decreased nicouline-induced PC12 cell apoptosis as compared with control cells ( p < 0.001).

  11. Tesis de doctorado tema colombiano

    Directory of Open Access Journals (Sweden)

    Boletín Cultural y Bibliográfico Banco de la República

    2004-09-01

    Full Text Available La lista publicada a continuación corresponde a tesis obsequiadas a la Biblioteca Luis Ángel Arango por el Institut des Hautes Études de l'Amérique Latine y por el Centre de Recherche et de Documentation sur l'Amérique Latine. Se recibieron en formato de microficha, como parte de una donación más amplia, que comprende 1.362 tesis sobre temas de América Latina. Acompaña la colección un CD-ROM que incluye un catálogo completo, que puede consultarse mediante búsquedas por autor, país, tema, título, periodo histórico, universidad, etc.

  12. Innovar modelos de gestión para mejorar la calidad de los doctorados en educación en Colombia

    Directory of Open Access Journals (Sweden)

    Gilma Rosa Sanabria León

    2012-01-01

    Full Text Available La investigación que da origen a este artícul o se orientó a comprender los factores de calidad y las prácticas de gestión presentes en los Programas de Formación Doctoral en Educación en Colombia, centrada en el caso específico de un programa doctoral de la Ciudad de Bogotá. Se visibilizan preocupant es indicadores que reflejan deficiencias en los factores y características de calidad, tanto en lo relacionado a la organización, gestión e impacto social del conocimiento, como en los objetivos misionales del programa académico. Se evidencia además una ba ja producción académica y de investigación, y la que existe presenta un mediano impacto teórico, metodológico y social. Un Programa Doctoral en Educación endogámico, con poco diálogo e interacción con programas similares a nivel regional, nacional e intern acional, presentando un escaso trabajo colaborativo, en red y de conexiones que estimulen el debate de saberes necesario en este alto nivel de formación. Se identificaron también, sin embargo , fortalezas destacables vistas desde los indicadores nacionales e internacionales, a pesar de que las políticas nacionales e institucionales no apoyan en forma decidida ni estimulan los programas de investigación en educación. Así, este artículo plantea la necesidad de dar un salto a nuevos modelos de gestión educativa a partir del análisis de un caso concreto, desde la certeza de que la evaluación constituye el primer paso para redimensionar la organización del trabajo conjunto hacia la construcción de un sistema que permita mejorar la calidad de los doctorados en educ ación en Colombia.

  13. DIMENSIONES CULTURALES DE LA NOCIÓN DE TUTORÍA ACADÉMICA EN DOCENTES Y ALUMNOS DE DOCTORADO, MÉXICO

    Directory of Open Access Journals (Sweden)

    María de los A. Aguilera V.

    2011-01-01

    Full Text Available En este artículo se presenta un estudio en donde se analizaron las dimensiones culturales de las tutorías académicas a través de describir los significados, explorar la estructura cognitiva y conocer el consenso cultural en los docentes y alumnos del Doctorado en Ciencias de la Salud en el Trabajo de la Universidad de Guadalajara. Método, Se trató de un estudio cualitativo con diseño descriptivo, transversal y exploratorio, realizado en México en el 2009. Los datos fueron recolectados con las técnicas listados libres y sorteo por montones, en fases sucesivas, y analizados en el modelo de dominios culturales. Resultados, La noción de tutoría académica se definió principalmente a través del apoyo y la asesoría. Las dimensiones cognitivas del concepto revelaron una visión diferente y complementaria en docentes y alumnos. En los docentes incluyó el equilibrio entre el proceso tutoral y las tareas tutorales. En los alumnos implicó un desarrollo muy amplio de las funciones de los tutores y en menor medida de los elementos para aprender. El elemento empatía se encontró ausente en los docentes, así como el uso de las herramientas para la actividad tutoral, los escenarios virtuales y la comunicación tutoral, en ambos informantes. Se observó consenso cultural en razón 5.101 en docentes y 3.516 en alumnos. Nivel promedio de competencia cultural 0.604 en docentes y 0.422 en alumnos. Conclusiones: Los elementos para considerarse en el diseño de nuevas estrategias comprenden una perspectiva complementaria entre docentes y alumnos que incluya un desarrollo muy claro y extenso de las funciones tutorales, de los elementos necesarios para aprender y del proceso tutoral.

  14. ¿Cómo tener éxito en un doctorado en Psicología? Opinión de los directores de Tesis Doctorales más productivos en España

    Directory of Open Access Journals (Sweden)

    Diana Agudelo

    2003-01-01

    Full Text Available En este trabajo se realiza un análisis de las opiniones de los directores más productivos en Tesis Doctorales de las áreas académicas de la Psicología española entre 1992 y 2001. El método empleado fue una entrevista sobre diferentes aspectos del doctorado y cómo realizarlo con éxito. Las opiniones de los 21 directores entrevistados constituyeron la unidad de análisis. Los resultados revelan distintas perspectivas de los directores, destacando múltiples argumentos como razones para realizar un doctorado, los criterios considerados para seleccionar al tutor/director de tesis según su calidad y trayectoria investigadora, la elección de los cursos acorde con los intereses del doctorando y los docentes que los imparten, y la determinación del tema de tesis por su utilidad y aplicabilidad. Se proponen medidas de mejora para el tercer ciclo en España, encaminadas a regular la calidad del profesorado y la selección de los alumnos y ofrecer mayor disponibilidad de recursos económicos y de infraestructura para el desarrollo de la investigación. Se realizan reflexiones sobre la utilidad de estas opiniones, el panorama de los estudios de doctorado en general y la importancia de replantear algunos aspectos de la formación doctoral en España con el objetivo de alcanzar los estándares de calidad requeridos.

  15. La institucionalización de los estudios culturales en Estados Unidos: el caso del doctorado en estudios culturales en la Universidad de Ccalifornia, Davis, a ocho años

    OpenAIRE

    Robert McKee Irwin

    2007-01-01

    Este artículo describe el proceso de institucionalización del campo de estudios culturales en los Estados Unidos. El ejemplo de este proceso en la experiencia de la Universidad de California, Davis, donde se estableció hace ocho años un doctorado en estudios culturales, aunque idiosincrático, ilustra el tipo de problemas, tanto prácticos como intelectuales, que tal institucionalización ha provocado en este país. Eel artículo señala también dos áreas el contenido cultural y la gestión cultural...

  16. [Effects of Morus alba and Setaria italica intercropping on their plant growth and diurnal variation of photosynthesis].

    Science.gov (United States)

    Zhu, Wen-Xu; Zhang, Hui-Hui; Xu, Nan; Wang, Peng; Wang, Shi-Dan; Mu, Shi-Nan; Liang, Ming; Sun, Guang-Yu

    2012-07-01

    A field investigation was conducted to study the effects of intercropping Morus aIba and Setaria italica on their dry matter production, land use efficiency, and diurnal variation of leaf photosynthesis. Under intercropping, the plant height, basal diameter, root length, and branch number of M. alba increased by 6.0%, 13.7%, 6.8%, and 14.8%, respectively, and the leaf yield of M. alba was increased by 31.3%, as compared with monoculture M. alba. In contrast, the plant height and root length of intercropped S. italica had no significant difference with those of monoculture S. italica. Intercropping enhanced the equivalent ratio and use efficiency of arable land. For both M. alba and S. italica in monoculture or intercropping, their leaf photosynthetic depression all occurred at midday (12 :00), but the leaf photosynthetic depression of monoculture M. alba was heavier than that of intercropped M. alba. Intercropping promoted the leaf stomatal conductance (g(s)) and water use efficiency (WUE) of M. alba at midday, increased the photosynthetic carbon assimilation of M. alba, and inhibited the decline of M. alba leaf actual photochemical efficiency of PS II (phi(PS II)), photosynthetic electron transport rate (ETR), and the maximal photochemical of PS II (F(v)/F(m)) , which might contribute to alleviate the leaf photosynthetic depression of M. alba at midday. It was concluded that M. alba and S. italica intercropping could obviously improve the leaf photosynthetic capacity of M. alba.

  17. Response of Salix alba L. to heavy metals and diesel fuel ...

    African Journals Online (AJOL)

    Response of Salix alba L. to heavy metals and diesel fuel contamination. ... Ni and Pb led to reduced accumulation of Pb. Presence of 5 g/kg of diesel fuel in soil significantly increased toxic influence of applied heavy metals by further reducing ... Key words: Cd, Ni, Pb, phytoremediation, phytoextraction, willow, Salix alba.

  18. Counter-Hegemonic Regionalism and Higher Education for All: Venezuela and the ALBA

    Science.gov (United States)

    Muhr, Thomas

    2010-01-01

    This paper employs new regionalism theory and regulatory regionalism theory in its analysis and theorisation of the Bolivarian Alliance for the Peoples of Our America (ALBA) as a counter-hegemonic Latin American and Caribbean (LAC) regionalism. As (initially) the regionalisation of Venezuela's Bolivarian Revolution, ALBA is centred around the idea…

  19. Parasiticidal effects of Morus alba root bark extracts against Ichthyophthirius multifiliis infecting grass carp

    Science.gov (United States)

    Ichthyophthirius multifiliis (Ich) is an important fish parasite that can result in significant losses in aquaculture. In order to find efficacious drugs to control Ich, the root bark of Morus alba, a traditional Chinese medicine, was evaluated for its antiprotozoal activity. The M. alba root bark w...

  20. Activation of macrophage mediated host defense against Salmonella typhimurium by Morus alba L.

    Science.gov (United States)

    Chang, BoYoon; Koo, BongSeong; Lee, HyeonCheol; Oh, Joa Sub; Kim, SungYeon

    2018-01-01

    The innate immune system plays a crucial role in the initiation and subsequent direction of adaptive immune responses, as well as in the removal of pathogens that have been targeted by an adaptive immune response. Morus alba L. was reported to have immunostimulatory properties that might protect against infectious diseases. However, this possibility has not yet been explored. The present study investigated the protective and immune-enhancing ability of M. alba L. against infectious disease and the mechanisms involved. To investigate the immune-enhancing effects of M. alba L., we used a bacterial infection model. The lifespan of mice infected with a lethal dose of Salmonella typhimurium (1 × 10 7 colony forming units - CFU) was significantly extended when they were administered M. alba L. Furthermore, M. alba L. activated macrophages, monocytes, and neutrophils and induced Th1 cytokines (IL-12, IFN-γ, TNF-α) in mice infected with a sublethal dose (1 × 10 5 CFU) of S. typhimurium . M. alba L. significantly stimulated the uptake of bacteria into peritoneal macrophages as indicated by increased phagocytosis. Peritoneal macrophages derived from C3H/HeJ mice significantly inhibited M. alba L. induced NO production and TNF-α secretion compared with peritoneal macrophages derived from C3H/HeN mice. These results suggest that the innate immune activity of M. alba L. against bacterial infection in mice occurs through activation of the TLR4 signaling pathway.

  1. Regio-selective deglycosylation of icariin by cell suspension cultures of Glycyrrhiza uralensis and Morus alba.

    Science.gov (United States)

    Zhang, De-Wu; Tao, Xiao-Yu; Chen, Ri-Dao; Yu, Li-Yan; Dai, Jun-Gui

    2015-01-01

    Biotransformations of icariin (1) by cell suspension cultures of Glycyrrhiza uralensis and Morus alba yielded two new metabolites, icaruralins A and B (2 and 3), and one known metabolite, baohuoside I (4). Their structures were determined on the basis of extensive spectroscopic analysis. This is the first report that the cell suspension cultures of G. uralensis and M. alba possess deglycosylation functionality.

  2. Genome-Wide Identification of the Alba Gene Family in Plants and Stress-Responsive Expression of the Rice Alba Genes.

    Science.gov (United States)

    Verma, Jitendra Kumar; Wardhan, Vijay; Singh, Deepali; Chakraborty, Subhra; Chakraborty, Niranjan

    2018-03-28

    Architectural proteins play key roles in genome construction and regulate the expression of many genes, albeit the modulation of genome plasticity by these proteins is largely unknown. A critical screening of the architectural proteins in five crop species, viz., Oryza sativa , Zea mays , Sorghum bicolor , Cicer arietinum , and Vitis vinifera , and in the model plant Arabidopsis thaliana along with evolutionary relevant species such as Chlamydomonas reinhardtii , Physcomitrella patens , and Amborella trichopoda , revealed 9, 20, 10, 7, 7, 6, 1, 4, and 4 Alba (acetylation lowers binding affinity) genes, respectively. A phylogenetic analysis of the genes and of their counterparts in other plant species indicated evolutionary conservation and diversification. In each group, the structural components of the genes and motifs showed significant conservation. The chromosomal location of the Alba genes of rice ( OsAlba ), showed an unequal distribution on 8 of its 12 chromosomes. The expression profiles of the OsAlba genes indicated a distinct tissue-specific expression in the seedling, vegetative, and reproductive stages. The quantitative real-time PCR (qRT-PCR) analysis of the OsAlba genes confirmed their stress-inducible expression under multivariate environmental conditions and phytohormone treatments. The evaluation of the regulatory elements in 68 Alba genes from the 9 species studied led to the identification of conserved motifs and overlapping microRNA (miRNA) target sites, suggesting the conservation of their function in related proteins and a divergence in their biological roles across species. The 3D structure and the prediction of putative ligands and their binding sites for OsAlba proteins offered a key insight into the structure-function relationship. These results provide a comprehensive overview of the subtle genetic diversification of the OsAlba genes, which will help in elucidating their functional role in plants.

  3. A diferença cultural nas diretrizes curriculares nacionais e nos projetos curriculares dos cursos de pedagogia da UFPE

    OpenAIRE

    Freitas de Melo, Simony

    2011-01-01

    A pesquisa trata da diferença cultural no curso de pedagogia, representado pelas políticas curriculares nacionais e pelos seus respectivos projetos curriculares institucionais da UFPE. Procuramos compreender como a diferença cultural é tratada nas Diretrizes Curriculares Nacionais do Curso de Pedagogia e nos Currículos dos cursos de pedagogia do Centro de Educação e do Centro Acadêmico do Agreste, ambos da UFPE. Procuramos ainda, compreender em que perspectiva multicultural os documentos anal...

  4. Bioconcentraciones foliares de elementos minerales en Lippia alba (salvia morada)

    OpenAIRE

    Schroeder, María A; Burgos, Ángela M

    2013-01-01

    Introducción: la salvia morada es un subarbusto aromático, que crece de modo espontáneo en América Central y del Sur. Frecuentemente es cultivada en jardines como ornamental, por su intenso aroma y sus propiedades medicinales y culinarias. No se encontraron estudios sobre parámetros nutricionales en esta especie. Objetivos: determinar las bioconcentraciones foliares de elementos minerales en Lippia alba (Mill.) N. E. Br. ex Britton & P. Wilson que crece naturalmente en el bioambiente del nort...

  5. Pyrrole alkaloids from the fruits of Morus alba.

    Science.gov (United States)

    Kim, Seon Beom; Chang, Bo Yoon; Hwang, Bang Yeon; Kim, Sung Yeon; Lee, Mi Kyeong

    2014-12-15

    Phytochemical investigation of the fruits of Morus alba afforded seventeen pyrrole alkaloids including five new compounds. The structures of five new pyrrole alkaloids, named morroles B-F (4, 5, 7, 16 and 17), were determined on the basis of spectroscopic interpretations. 4-[Formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]butanoate (2) was synthesized by chemical reaction but first isolated from nature. Among isolated compounds, compounds 6 and 14 significantly inhibited pancreatic lipase activity. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. [Advances in the pharmacological study of Morus alba L].

    Science.gov (United States)

    Yang, Shuang; Wang, Bao-Lian; Li, Yan

    2014-06-01

    Morus alba L. (mulberry) is a well-known deciduous tree, belonging to the genus of Morus of Moraceae famlily. Its leaves, twigs, roots (bark) and fruits are widely used in the traditional Chinese medicine. The active constituents of mulberry contained flavonoids, alkaloids, steroids, coumarins, with the significant hypoglycemic, hypolipidemic, antihypertension, anti-oxidation, anti-inflammatory, anti-bacterial, anti-tumor and immunomodulatory activities. This review summarized the research progress of the major pharmacological activity, pharmacokinetics and drug-drug interaction based on CYPs and transporters of mulberry and its active constituents.

  7. Children's self-allocation and use of classroom curricular time.

    Science.gov (United States)

    Ingram, J; Worrall, N

    1992-02-01

    A class of 9-10 year-olds (N = 12) in a British primary school were observed as it moved over a one-year period through three types of classroom environment, traditional directive, transitional negotiative and established negotiative. Each environment offered the children a differing relationship with curricular time, its control and allocation, moving from teacher-allocated time to child allocation. Pupil self-report and classroom observation indicated differences in the balance of curricular spread and allocated time on curricular subject in relation to the type of classroom organisation and who controlled classroom time. These differences were at both class and individual child level. The established negotiative environment recorded the most equitable curricular balance, traditional directive the least. While individual children responded differently within and across the three classroom environments, the established negotiative where time was under child control recorded preference for longer activity periods compared to where the teacher controlled time allocations.

  8. Strategic Curricular Decisions in Butler University's Actuarial Science Major

    Science.gov (United States)

    Wilson, Christopher James

    2014-01-01

    We describe specific curricular decisions employed at Butler University that have resulted in student achievement in the actuarial science major. The paper includes a discussion of how these decisions might be applied in the context of a new actuarial program.

  9. El diseño curricular, una responsabilidad compartida

    OpenAIRE

    Pedro Sarmiento; María Clara Tovar

    2011-01-01

    Introducción: El diseño o rediseño curricular de un programa académico incluye las fases de fundamentación, definiciónde ejes problemáticos y estructuración. El estudio pretende fomentar la reflexión sobre la práctica y la investigación en elcampo curricular y fortalecer las políticas institucionales relacionadas con el diseño curricular de los programas académicos,en procura de mejorar la pertinencia y la calidad del currículo.Objetivo: Describir las prácticas del diseño curricular en los pr...

  10. El diseño curricular, una responsabilidad compartida

    OpenAIRE

    Tovar, María Clara; Sarmiento, Pedro

    2011-01-01

    Introducción: El diseño o rediseño curricular de un programa académico incluye las fases de fundamentación, definición de ejes problemáticos y estructuración. El estudio pretende fomentar la reflexión sobre la práctica y la investigación en el campo curricular y fortalecer las políticas institucionales relacionadas con el diseño curricular de los programas académicos, en procura de mejorar la pertinencia y la calidad del currículo. Objetivo: Describir las prácticas del diseño curricular en lo...

  11. [Communication in medicine: a new and much needed curricular alternative].

    Science.gov (United States)

    Halac, Eduardo; Quiroga, Daniel; Olmas, Josè M; Trucchia, Silvina M

    2016-01-01

    Medical education must emphasize communication practices mostly for undergraduate medical students. To introduce an approach for teaching and learning communication in medicine. An approach for developing communicational practices for both undergraduate and post graduate students is presented. Medical communication is not taught adequately in modern medical schools and is allotted a brief curricular space.. This curricular time must be widened in order to support communication's central role.

  12. Latest developments at the ALBA magnetic measurements laboratory

    Science.gov (United States)

    Marcos, J.; Massana, V.; García, L.; Campmany, J.

    2018-02-01

    ALBA is a third-generation synchrotron light source that has been in operation since 2012 near Barcelona. A magnetic measurements laboratory has been associated with the facility since its very early stages and has been active for the last 20 years. In the first part of this work, the different instruments available at the laboratory are described, and a brief overview of the measurement campaigns carried out during its 20 years of history is presented. In the second part, a more detailed description of the approach to Hall probe measurements adopted at ALBA is offered, with an explanation of the methods and ancillary equipment that have been developed along the years in order to improve the accuracy of the system. In the third part, a new concept of Hall probe bench devoted to the measurement of closed structures is presented. The in-house design and building of a prototype for such a bench is described, together with its mechanical and magnetic characterization. As a conclusion, the first results obtained with this bench are discussed.

  13. Hypocholesterolemic and Antiatherosclerotic Potential of Basella alba Leaf Extract in Hypercholesterolemia-Induced Rabbits

    Directory of Open Access Journals (Sweden)

    Gunasekaran Baskaran

    2015-01-01

    Full Text Available Hypercholesterolemia is the major risk factor that leads to atherosclerosis. Nowadays, alternative treatment using medicinal plants gained much attention since the usage of statins leads to adverse health effects, especially liver and muscle toxicity. This study was designed to investigate the hypocholesterolemic and antiatherosclerotic effects of Basella alba (B. alba using hypercholesterolemia-induced rabbits. Twenty New Zealand white rabbits were divided into 5 groups and fed with varying diets: normal diet, 2% high cholesterol diet (HCD, 2% HCD + 10 mg/kg simvastatin, 2% HCD + 100 mg/kg B. alba extract, and 2% HCD + 200 mg/kg B. alba extract, respectively. The treatment with B. alba extract significantly lowered the levels of total cholesterol, LDL, and triglycerides and increased HDL and antioxidant enzymes (SOD and GPx levels. The elevated levels of liver enzymes (AST and ALT and creatine kinase were noted in hypercholesterolemic and statin treated groups indicating liver and muscle injuries. Treatment with B. alba extract also significantly suppressed the aortic plaque formation and reduced the intima: media ratio as observed in simvastatin-treated group. This is the first in vivo study on B. alba that suggests its potential as an alternative therapeutic agent for hypercholesterolemia and atherosclerosis.

  14. Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism.

    Science.gov (United States)

    Mahmoud, Ayman M; Abd El-Twab, Sanaa M; Abdel-Reheim, Eman S

    2017-06-01

    Beneficial effects of white mulberry against diabetes mellitus have been reported. However, the molecular mechanisms of how white mulberry can attenuate diabetic retinopathy remain poorly understood. Here, the mechanism underlying the protective effect of Morus alba leaves ethanolic extract on oxidative stress, inflammation, apoptosis, and angiogenesis in diabetic retinopathy was investigated. Diabetes was induced by injection of streptozotocin. One week after, M. alba (100 mg/kg) was administrated to the rats daily for 16 weeks. Morus alba extract showed high content of polyphenolics and free radical scavenging activity. Oral M. alba administration significantly attenuated hyperglycemia and weight loss, and decreased sorbitol, fructose, protein kinase C, pro-inflammatory cytokines, and oxidative stress markers in retinas of the diabetic rats. Moreover, M. alba produced marked down-regulation of caspase-3 and Bax, with concomitant up-regulation of Bcl-2 in the diabetic retinas. M. alba also reduced the expression of VEGF in the retina. These results indicate that M. alba has protective effect on diabetic retinopathy with possible mechanisms of inhibiting hyperglycemia-induced oxidative stress, apoptosis, inflammation, polyol pathway activation, and VEGF expression in the retina.

  15. ANALYSIS OF THE EVOLUTION IN DYNAMICS OF BUDGET INCOMES FROM ALBA COUNTY

    Directory of Open Access Journals (Sweden)

    CLAUDIA FLORINA RADU

    2013-03-01

    Full Text Available This paper aims to examine how the main taxes collected in Alba County have evolved over the last seven years and we put in evidence the evolution of total revenue received in Alba County budget. We point out also the taxes that hold the largest share of the total revenue collected. At the same time we observe the ranking of the main taxes in our county, compared to their ranking of the entire country. On the first place in our county we find VAT, the income tax is on the second, and corporate income tax follows. They are therefore the main source of income for the Alba budget.

  16. ANALIZA VENITURILOR BUGETARE LA NIVELUL JUDEłULUI ALBA ÎN PERIOADA 2006-2010

    Directory of Open Access Journals (Sweden)

    Claudia Florina Radu

    2011-01-01

    Full Text Available Analysis of the Stat Budget Incomes from Alba County during 2006-2010The study aims to examine how the main taxes collected in Alba County have evolved overthe last five years. We wish to point out also the taxes that hold the largest share of the totalrevenue collected. Such way, on the first place we find the income tax, than VAT is on thesecond and corporate income tax followes. They are therefore the main source of incomefor the Alba county budget.

  17. Characterization of functional SSR markers in Prosopis alba and their transferability across Prosopis species

    Directory of Open Access Journals (Sweden)

    María F. Pomponio

    2015-08-01

    Full Text Available Aim of study: The aim of the study was to characterize functional microsatellite markers in Prosopis alba and examine the transferability to species from the Prosopis genus. Area of the study: samples were obtained from natural populations of Argentina. Material and Methods: Eleven SSR functional markers related to stress and metabolism were amplified in a sample of 152 genotypes from P.alba, P. denudans, P. hassleriP. chilensis, P. flexuosa, and interspecific hybrids. Main results: In P. alba, the PIC average value was 0.36; and 6 out of the 11 primers showed high values of polymorphism ranging from 0.40 to 0.71. The cross-species transferability was high with high percentages of polymorphic loci. Research highlights: The SSR markers developed in P.alba were easily transferred to other Prosopis species which did not have functional markers.

  18. DEVELOPMENT POLICIES IN ALBA IULIA AREA OF INFLUENCE. AN INTEGRATED APPROACH

    Directory of Open Access Journals (Sweden)

    S. A. NICULA

    2015-06-01

    Full Text Available Development Policies in Alba Iulia Area of Influence. An Integrated Approach. The paper represents an integrated and holarchical perspective on the spatial development policies and its component measures and projects related to the City of Alba Iulia, its area of influence and the all-encompassing County of Alba, Romania. The goal was to see how the development and management policies from all levels merge into a single strategic framework that might create a favourable basis for the sustainable growth of Alba Iulia and its area of influence. As this area surrounding the city is subjected to different hierarchical plans and programmes, some that are not properly correlated, it is extremely clear that this area and Areas of Influence in general need legislative stipulations made specifically for them and also a well-thought holarchical planning approach.

  19. Adventitious bud regeneration from the stigma of Sinapis alba L.

    Directory of Open Access Journals (Sweden)

    Elżbieta Zenkteler

    2012-12-01

    Full Text Available Stigmas isolated from flower buds of 'Nakielska' variety of Sinapis alba were used to develop a micropropagation method suitable for breeding of new cultivars. The origin of adventitious bud regeneration was studied on MS medium, under stimulation by bezylaminopurine (BAP in combination with 2,4-D - dichlorophenoxyacetic acid (2,4-D. Histological analysis showed the structure of Sinapis stigma (composed from four types of tissue: papillae, transmitting tissue, parenchyma and vascular bundles and revealed that numerous meristematic centers developed from parenchyma cells in close vicinity of vascular bundles. Buds very quickly appeared on the surface of initial explants and later formed multiplantlets that were easily rooted in the soil.

  20. Triterpenoid saponins from Lippia alba (Mill.) N. E. Brown

    International Nuclear Information System (INIS)

    Farias, Mareni R.; Pertile, Roberto; Correa, Melissa M.; Schenkel, Eloir P.; Almeida, Maria Tereza R. de; Palermo, Jorge A.

    2010-01-01

    Two saponins were isolated from the leaves of Lippia alba. Their structures were established using one- and two-dimensional NMR spectroscopy and mass spectrometry. These new compounds were elucidated as 3-O-β-D-glucopyranosyl-28-O-(α-L-rhamnopyranosyl-(1→3)-beta-D-xylopyranosyl -(1→4)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl)-16α, 23-dihydroxy-olean -12-en-28-oic acid, named as Lippiasaponin I (2) and as 3-O-β-D-glucopyranosyl-28-O-(α-L-rhamnopyranosyl-(1→3)-β-D-xylopyranosyl- (1→4)-α-L-rhamnopyranosyl-(1→3)-α-Larabinopyranosyl)-16α,23-dihydroxy-olean -12-en-28-oic acid, named Lippiasaponin II (3). (author)

  1. Triterpenoid saponins from Lippia alba (Mill.) N. E. Brown

    Energy Technology Data Exchange (ETDEWEB)

    Farias, Mareni R.; Pertile, Roberto; Correa, Melissa M.; Schenkel, Eloir P., E-mail: marenif@yahoo.com.b [Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC (Brazil). Dept. de Ciencias Farmaceuticas. Programa de Pos-graduacao em Farmacia; Almeida, Maria Tereza R. de; Palermo, Jorge A. [Universidad de Buenos Aires (Argentina). Facultad de Ciencias Exactas y Naturales. Dept. de Quimica Organica

    2010-07-01

    Two saponins were isolated from the leaves of Lippia alba. Their structures were established using one- and two-dimensional NMR spectroscopy and mass spectrometry. These new compounds were elucidated as 3-O-beta-D-glucopyranosyl-28-O-(alpha-L-rhamnopyranosyl-(1->3)-beta-D-xylopyranosyl -(1->4)-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranosyl)-16alpha, 23-dihydroxy-olean -12-en-28-oic acid, named as Lippiasaponin I (2) and as 3-O-beta-D-glucopyranosyl-28-O-(alpha-L-rhamnopyranosyl-(1->3)-beta-D-xylopyranosyl- (1->4)-alpha-L-rhamnopyranosyl-(1->3)-alpha-Larabinopyranosyl)-16alpha,23-dihydroxy-olean -12-en-28-oic acid, named Lippiasaponin II (3). (author)

  2. Electromagnetic field pretreatment of Sinapis alba seeds improved cadmium phytoextraction.

    Science.gov (United States)

    Bulak, Piotr; Lata, Lesia; Plak, Andrzej; Wiącek, Dariusz; Strobel, Wacław; Walkiewicz, Anna; Pietruszewski, Stanisław; Bieganowski, Andrzej

    2018-03-21

    It was hypothesized that electromagnetic field (EMF) pretreatment of white mustard (Sinapis alba L.) seeds could increase the accumulation of non-essential, pollutant heavy metals such as cadmium (Cd) in shoots. Seeds of white mustard were treated with either 60 or 120 mT of alternating EMF (50 Hz) for 1 minute and then grown in a Petri dish in the presence of Cd, in comparison to the control (seeds grown without EMF pretreatment). Biomass production and content of calcium (Ca) and Cd in seedling shoots were measured. The Cd content in shoots from the EMF-treated seeds was higher in both variants than in the control (by 73% and 78%, respectively; p phytoextraction, but more research is needed.

  3. Chemical Diversity in Lippia alba (Mill. N. E. Brown Germplasm

    Directory of Open Access Journals (Sweden)

    Arie Fitzgerald Blank

    2015-01-01

    Full Text Available The aim of this study was to perform chemical characterization of Lippia alba accessions from the Active Germplasm Bank of the Federal University of Sergipe. A randomized block experimental design with two replications was applied. The analysis of the chemical composition of the essential oils was conducted using a gas chromatograph coupled to a mass spectrometer. The chemical composition of the essential oils allowed the accessions to be allocated to the following six groups: group 1: linalool, 1,8-cineole, and caryophyllene oxide; group 2: linalool, geranial, neral, 1,8-cineol, and caryophyllene oxide; group 3: limonene, carvone, and sabinene; group 4: carvone, limonene, g-muurolene, and myrcene; group 5: neral, geranial, and caryophyllene oxide; and group 6: geranial, neral, o-cymene, limonene, and caryophyllene oxide.

  4. Radioactively labelled phytic acid from maturing seeds of sinapis alba

    International Nuclear Information System (INIS)

    Blaicher, F.M.; Mukherjee, K.D.

    1981-01-01

    Maturing seeds of Sinapis alba were incubated with D-[U- 14 C]glucose, sodium [1- 14 C] acetate or myo-[U 14 C] inositol in order to prepare radioactively labelled phytic acid with high specific activity. Although each substrate was utilized for the biosynthesis of phytic acid, maximum incorporation of radioactivity into phytic acid was found with myo-inositol. Radiochemical purity of the [U- 14 C]phytic acid preparations was confirmed by chromatographic techniques. Such preparations should be useful for the study of interaction of phytic acid with metal ions and proteins and may serve as substrate in the assay should be useful for the study of interaction of phytic acid with metal ions and proteins and may serve as substrate in the assay of phytase. (orig.)

  5. Radioactively labelled phytic acid from maturing seeds of Sinapis alba

    Energy Technology Data Exchange (ETDEWEB)

    Blaicher, F.M.; Mukherjee, K.D.

    Maturing seeds of Sinapis alba were incubated with D-(U-/sup 14/C)glucose, sodium (1-/sup 14/C) acetate or myo-(U/sup 14/C) inositol in order to prepare radioactively labelled phytic acid with high specific activity. Although each substrate was utilized for the biosynthesis of phytic acid, maximum incorporation of radioactivity into phytic acid was found with myo-inositol. Radiochemical purity of the (U-/sup 14/C)phytic acid preparations was confirmed by chromatographic techniques. Such preparations should be useful for the study of interaction of phytic acid with metal ions and proteins and may serve as substrate in the assay should be useful for the study of interaction of phytic acid with metal ions and proteins and may serve as substrate in the assay of phytase.

  6. Characterization of functional SSR markers in Prosopis alba and their transferability across Prosopis species

    OpenAIRE

    María F. Pomponio; Cintia Acuña; Vivien Pentreath; Diego L. Lauenstein; Susana M. Poltri; Susana Torales

    2015-01-01

    Aim of study: The aim of the study was to characterize functional microsatellite markers in Prosopis alba and examine the transferability to species from the Prosopis genus. Area of the study: samples were obtained from natural populations of Argentina. Material and Methods: Eleven SSR functional markers related to stress and metabolism were amplified in a sample of 152 genotypes from P.alba, P. denudans, P. hassleriP. chilensis, P. flexuosa, and interspecific hybrids. Main res...

  7. ANALIZA VENITURILOR BUGETARE LA NIVELUL JUDEŢULUI ALBA ÎN PERIOADA 2006-2010

    Directory of Open Access Journals (Sweden)

    Claudia Florina Radu

    2011-01-01

    Full Text Available Analysis of the Stat Budget Incomes from Alba County during 2006-2010The study aims to examine how the main taxes collected in Alba County have evolved overthe last five years. We wish to point out also the taxes that hold the largest share of the totalrevenue collected. So, on the first place we find the income tax, than VAT is the second andcorporate income tax followes. They are therefore the main source of income for the Albacounty budget.

  8. Allelopathic influence of aqueous extracts from the leaves of Morus alba L. on seed germination and seedling growth of Cucumis sativus L. and Sinapsis alba L.

    Directory of Open Access Journals (Sweden)

    Katarzyna Możdżeń

    2014-04-01

    Full Text Available The aim of the present study was to elucidate impact of the aqueous extracts from leaves of Morus alba L. on germination, growth and photosynthetic activity of Cucumis sativus L. and Sinapis alba L. Plants were grown for 21 days at the temperature 25°C (day and 18°C (night, within 12/12 hours photoperiod, light intensity 150 μmol·m-2·s-1 and relative humidity 60-70% (day/night. Our experiments proved that allelopathic compounds in aqueous extracts of the leaves M. alba at high concentrations, reduce power and energy of germination. Biometric analysis of seedlings and adult plants grown showed that allelopathic substances have stimulating or inhibiting function depending on the stage of treatment. Moreover, they cause changes in chlorophyll contents and activity of photosystem II (PS II.

  9. Morus alba extract modulates blood pressure homeostasis through eNOS signaling.

    Science.gov (United States)

    Carrizzo, Albino; Ambrosio, Mariateresa; Damato, Antonio; Madonna, Michele; Storto, Marianna; Capocci, Luca; Campiglia, Pietro; Sommella, Eduardo; Trimarco, Valentina; Rozza, Francesco; Izzo, Raffaele; Puca, Annibale A; Vecchione, Carmine

    2016-10-01

    Morus alba is a promising phytomedicine cultivated in oriental countries that is extensively used to prevent and treat various cardiovascular problems. To date, despite its beneficial effects, the molecular mechanisms involved remain unclear. Thus, we investigate the vascular and haemodynamic effects of Morus alba extract in an experimental model focusing our attention on the molecular mechanisms involved. Through vascular reactivity studies, we demonstrate that Morus alba extract evokes endothelial vasorelaxation through a nitric oxide-dependent pathway. Our molecular analysis highlights an increase in endothelial nitric oxide synthase (eNOS) phosphorylation. In vivo administration of Morus alba extract reduces blood pressure levels exclusively in wild-type mice, whereas it fails to evoke any haemodynamic effects in eNOS-deficient mice. Molecular analyses revealed that its beneficial action on vasculature is mediated by the activation of two important proteins that act as stress sensors and chaperones: PERK and heat shock protein 90. Finally, Morus alba extract exerts antihypertensive action in an experimental model of arterial hypertension. Through its action on eNOS signaling, Morus alba extract could act as a food supplement for the regulation of cardiovascular system, mainly in clinical conditions characterized by eNOS dysfunction, such as arterial hypertension. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Nephro-protective potential of Morus alba, a prospective experimental study on animal models.

    Science.gov (United States)

    Ullah, Naveed; Khan, Mir Azam; Khan, Salimullah; Ahmad, Habib; Asif, Afzal Haq; Khan, Taous

    2016-01-01

    Morus alba L. (Moraceae) is traditionally used for the treatment of urinary incontinency due its strong diuretic properties. The present study explores the renal protective effects of M. alba, due to its free radical scavenging properties, in order to provide experimental evidence for its established use. Ethanolic extract (200 mg/kg/d) derived from M. alba fruit was employed in rabbits as a co-therapy (GM-al) with gentamicin (80 mg/kg/d) for a period of 3 weeks. Biochemical kidney functioning parameters, urinary isozymes, and histopathological examination were performed. The results showed that ethanol extract of Morus alba L. prevented alterations in serum creatinine (4.02 ± 0.14, p alba with gentamicin prevented renal functioning alterations expected with the use of gentamicin alone. Therefore, it can be concluded that M. alba to protect from kidney damage, which may be because of its free radical scavenging and diuretic properties.

  11. Formulation and evaluation of antimicrobial activity of Morus alba sol-gel against periodontal pathogens

    Directory of Open Access Journals (Sweden)

    Shilpa Gunjal

    2015-01-01

    Full Text Available Background: Periodontitis has a multifactorial etiology, with primary etiologic agents being pathogenic bacteria that reside in the subgingival area. Recent advances in the field of alternative medicine introduced various herbal products for the treatment of periodontitis. Aim: To assess and compare the antimicrobial activity of Morus alba sol-gel with chlorhexidine sol-gel against ATCC standard strains of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythia. Materials and Methods: Crude extract of Morus alba leaves was prepared by Soxhlet method by using ethanol as a solvent. Phytochemical screening of the crude extract of M. alba was performed to check the various chemical constituents. M. alba sol-gel and chlorhexidine sol-gel were formulated using Pluronic f127 and Pluronic f108 and compared for their antimicrobial activity. The minimum inhibitory concentration of both the gels was performed using agar well diffusion technique. Results: The minimum inhibitory concentration of M. alba sol-gel and chlorhexidine sol-gel against A. actinomycetemcomitans is 19 and 17 mm, T. forsythia is 12 and 21 mm, and P. gingivalis is 16 and 18 mm, respectively. Conclusion: Both M. alba and chlorhexidine sol-gel exhibited potent antimicrobial activity against periodontal pathogens.

  12. Enhanced Mulberroside A Production from Cell Suspension and Root Cultures of Morus alba Using Elicitation.

    Science.gov (United States)

    Komaikul, Jukrapun; Kitisripanya, Tharita; Tanaka, Hiroyuki; Sritularak, Boonchoo; Putalun, Waraporn

    2015-07-01

    Morus alba L. has been used in Asian traditional medicine as an anti-inflammatory, anti-asthmatic, anthelmintic and as a whitening agent in cosmetic products. Mulberroside A is the major active compound from M. alba root bark. In this study, cell suspension and root cultures of M. alba were established, and the effect of the elicitors on the enhancement of mulberroside A production in M. alba was investigated. The cell suspension and root cultures of M. alba were exposed to elicitors and then mulberroside A contents were determined by an indirect competitive ELISA method. High levels of mulberroside A were obtained by addition of 100 and 200 μM salicylic acid with 24 h exposure time in cell suspension cultures (37.9 ± 1.5 and 34.0 ± 4.7 mg/g dry wt., respectively). Furthermore, addition of yeast extract at 2 mg/mL with 24 h exposure time can significantly increase mulberroside A contents from both cell suspension (3.2-fold) and root cultures (6.6-fold). Mulberroside A contents from both cell suspension and root cultures after treatment with elicitors are similar or higher than those found in the intact root and root bark of several years old M. alba. These results indicate that mulberry tissue cultures using the elicitation method are interesting alternative sources for mulberroside A production.

  13. Pharmacological basis for the medicinal use of Morus alba in gut and airways disorders

    Directory of Open Access Journals (Sweden)

    Munasib Khan

    2012-12-01

    Full Text Available Crude extract of Morus alba at 100 mg/kg exhibited protective effect against castor oil-induced diarrhea in mice. In isolated rabbit jejunum, M. alba (0.3-10 mg/mL inhibited the spontaneous contractions and caused glibenclamide-sensitive inhibition of low K+ (20 mM-induced contractions, with mild effect on high K+ (80 mM. Similarly, cromakalim caused inhibition of low K+, but not of high K+, while verapamil did not differentiate in its inhibitory effect on two concentrations of K+. M. alba (3.0-30 mg/kg caused suppression of carbachol (100 µg/kg-induced increase in inspiratory pressure of anaesthetized rats. In guinea-pig trachea, M. alba completely inhibited low K+ contractions, with partial effect on high K+. M. alba (0.3-1.0 mg/mL caused leftward shift of isoprenaline-induced inhibitory concentration response curves, like papaverine. These results indicate that M. alba possesses a combination of KATP channel opening, weak Ca++-antagonist and phosphodiesterase inhibitory mechanisms, which explain its medicinal use in hyperactive gut and airways disorders.

  14. In vitro antibacterial activity of ethanolic extract of Morus alba leaf against periodontal pathogens.

    Science.gov (United States)

    Gunjal, Shilpa; Ankola, Anil V; Bhat, Kishore

    2015-01-01

    Antibiotic resistance is a major problem with inadvertent usage. Thus, there is a need to search for new antimicrobial agents of herbal origin to combat antibiotic resistance. One such plant is Morus alba which has a long history of medicinal use in traditional Chinese medicine. To compare the antibacterial activity of ethanolic extract of M. alba leaves with chlorhexidine gluconate against Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythia. Experimental in vitro study. Crude extract from the leaves of M. alba were prepared by Soxhlet extraction method by using ethanol as a solvent. Minimum inhibitory concentration (MIC) of the extract was assessed against A. actinomycetemcomitans, P. gingivalis and T. forsythia, and compared with that of chlorhexidine gluconate by broth dilution method. P. gingivalis was the most sensitive organism against the M. alba extract with an MIC value of 1.95 mg/ml; while T. forsythia and P. gingivalis both were most sensitive organisms against chlorhexidine gluconate with MIC values of 0.00781 mg/ml. M. alba possess good antibacterial activity against A. actinomycetemcomitans, P. gingivalis and T. forsythia and thus would be beneficial for the prevention and treatment of periodontal disease. However, chlorhexidine gluconate was found to be more effective when compared to M. alba.

  15. An occupational respiratory allergy caused by Sinapis alba pollen in olive farmers.

    Science.gov (United States)

    Anguita, J L; Palacios, L; Ruiz-Valenzuela, L; Bartolomé, B; López-Urbano, M J; Sáenz de San Pedro, B; Cano, E; Quiralte, J

    2007-04-01

    Sinapis alba (white mustard) is a entomophilic species included in the Brassicaceae family. To date it has not been related to allergic sensitization or clinical respiratory disease. Twelve olive orchard workers had a history of rhinitis and/or bronchial asthma that occurred during control weed management and/or harvest, from January to March. They underwent skin prick tests (SPT) with S. alba pollen extract and a standard battery of aeroallergens. Sinapis alba pollen extract was prepared for performing quantitative skin tests, enzyme allergosorbent test and nasal challenge test (NCT). A portable monitoring station and an urban volumetric Hirst-type spore trap were used for the aerobiological study. Eleven patients suffered from rhinitis and bronchial asthma and one had only from rhinitis. All patients were sensitized to S. alba pollen extract, and they showed a positive NCT response. In the urban aerobiologic monitoring station the amount of S. alba pollen only exceptionally reached peaks of 21 grains/m(3), whereas in the work environment peaks of 1801 grains/m(3) were detected between 15 February and 7 April. We demonstrate the existence of a new occupational allergen for olive farmers: S. alba pollen. We point out the importance of perform aerobiological sampling within the occupational environment for the detection and quantification of the allergenic source.

  16. Patient safety and infection control: bases for curricular integration.

    Science.gov (United States)

    Silva, Andréa Mara Bernardes da; Bim, Lucas Lazarini; Bim, Felipe Lazarini; Sousa, Alvaro Francisco Lopes; Domingues, Pedro Castania Amadio; Nicolussi, Adriana Cristina; Andrade, Denise de

    2018-05-01

    To analyze curricular integration between teaching of patient safety and good infection prevention and control practices. Integrative review, designed to answer the question: "How does curricular integration of content about 'patient safety teaching' and content about 'infection prevention and control practices' occur in undergraduate courses in the health field?". The following databases were searched for primary studies: CINAHL, LILACS, ScienceDirect, Web of Science, Scopus, Europe PMC and MEDLINE. The final sample consisted of 13 studies. After content analysis, primary studies were grouped into two subject categories: "Innovative teaching practices" and "Curricular evaluation. Patient safety related to infection prevention and control practices is present in the curriculum of health undergraduate courses, but is not coordinated with other themes, is taught sporadically, and focuses mainly on hand hygiene.

  17. Curricular trends in Malaysian medical schools: innovations within.

    Science.gov (United States)

    Azila, Nor Mohd Adnan; Rogayah, Jaafar; Zabidi-Hussin, Zabidi Azhar Mohd Hussin

    2006-09-01

    Various curricular innovations were adopted by medical schools worldwide in an attempt to produce medical graduates that could meet future healthcare needs of society locally and globally. This paper presents findings on curricular approaches implemented in Malaysian medical schools, in trying to meet those needs. Information was obtained from published records, responses from various questionnaires, personal communication and involvement with curricular development. Curricular innovations tended to be implemented in new medical schools upon their establishment. Established medical schools seemed to implement these innovations much later. Curricular trends appear to move towards integration, student-centred and problem-based learning as well as community-oriented medical education, with the Student-centred learning, Problem-based learning, Integrated teaching, Community-based education, Electives and Systematic programme (SPICES) model used as a reference. The focus is based on the premise that although the short-term aim of undergraduate medical education in Malaysia is to prepare graduates for the pre-registration house officer year, they must be able to practise and make decisions independently and be sensitive to the needs of the country's multiracial, multi-religious, and often remote communities. In most cases, curricular planning starts with a prescriptive model where planners focus on several intended outcomes. However, as the plan is implemented and evaluated it becomes descriptive as the planners reassess the internal and external factors that affect outcomes. A common trend in community-oriented educational activities is evident, with the introduction of interesting variations, to ensure that the curriculum can be implemented, sustained and the intended outcomes achieved.

  18. Analysis of curricular reform practices at Chinese medical schools.

    Science.gov (United States)

    Huang, Lei; Cai, Qiaoling; Cheng, Liming; Kosik, Russell; Mandell, Greg; Wang, Shuu-Jiun; Xu, Guo-Tong; Fan, Angela P

    2014-01-01

    A comprehensive search of the literature published between 2001 and 2010 was performed to gain a greater understanding of curricular reform practices at Chinese medical schools. There were 10,948 studies published between 2001 and 2010 that were retrieved from the database. Following preliminary screening, 76 publications from 49 different medical schools were selected. Thirty-one publications regarding clinical medicine curricular reforms were analyzed further. Of the 76 studies, 53 described curricular reforms that were instituted in theoretical courses, 22 described curricular reforms that were instituted in experimental courses, and 1 described curricular reforms that were instituted in a clinical skills training course. Of the 31 clinical medicine publications, 2 described reforms that were implemented for 3-year program medical students, 12 described reforms that were implemented for 5-year program medical students, 6 described reforms that were implemented for 7-year program medical students, and 2 described reforms that were implemented for 8-year program medical students. Currently, the majority of medical schools in China use the discipline-based curriculum model. Thirteen studies described transition to an organ-system-based curriculum model, 1 study described transition to a problem-based curriculum model, and 3 studies described transition to a clinical presentation-based curriculum model. In 7 studies educators decided to retain the discipline-based curriculum model while integrating 1 or several new courses to remedy the weaker aspects of the traditional curriculum, in 7 studies educators decided to integrate the preclinical courses with the clinical courses by using the systemic-integrating curricular system that dilutes classical disciplines and integrates material based on organ systems, and in 2 studies educators limited reforms to clinical courses only. Eight studies discussed the implementation of a formative evaluation system, 4 studies

  19. El diseño curricular desde la perspectiva de la actividad profesional / Curricular design: focus on professional performance

    Directory of Open Access Journals (Sweden)

    Idielyn Cabrera Marrero

    2017-09-01

    Full Text Available The analysis of the curricular design theories shows that the concept of performance has not yet been sufficiently studied, this explains actual inconsistencies in the design methodologies that claim to be focused on professional activity. However, in practice they are focusing professional problems instead, or simply copying other universities curricula without considering the particular country stage of development. Taking Chemical engineers as a referent point, the authors devise a methodology of curricular design focused on professional activity leading to the comprehension of this particular engineers ‘performance. The findings result from the application of the functional structural systemic method.

  20. Curricular Reform in Schools: The Importance of Evaluation

    Science.gov (United States)

    Agrawal, Mamta

    2004-01-01

    Evaluation plays a pivotal role in deciding what the learners learn and what the teachers teach in schools. The paper reports a study of English-language teaching conducted in Delhi State of India that sought to examine the assumption that a change in an evaluation pattern can trigger curricular reform. Did concomitant changes take place in the…

  1. History, Music and Law: Commemorative Cross-Curricularity

    Science.gov (United States)

    Woodcock, James

    2013-01-01

    James Woodcock continues his theme from "Teaching History 138" about the difference between superficial, thematic cross-curricularity and much more rigorous interdisciplinarity. His concern is to retain rather than compromise the integrity of the subject disciplines. Woodcock argues that interdisciplinary working adds value to learning…

  2. American Association of Dental Schools Curricular Guidelines for Oral Radiology.

    Science.gov (United States)

    Journal of Dental Education, 1980

    1980-01-01

    Oral radiology curricular guidelines developed by the American Association of Dental Schools are provided. The guidelines describe minimal conditions under which a satisfactory educational experience can be offered. Principles of x-radiation, radiobiological concepts, radiological health, radiographic technique, radiographic quality, and darkroom…

  3. Retention of Economics Principles by Undergraduates on Alternative Curricular Structures

    Science.gov (United States)

    Johnson, Daniel K. N.; Lybecker, Kristina M.; Taylor, Corrine H.

    2011-01-01

    The authors investigated whether the curricular structure of an economics course (semester, trimester, or compressed block schedule) has an effect on an undergraduate's subsequent retention of course material, while controlling for other relevant differences. They tested separately for theoretical or process comprehension and for graphical…

  4. Extra-Curricular Inequality. Research Brief. Edition 1

    Science.gov (United States)

    Sutton Trust, 2014

    2014-01-01

    This Research Briefing analyses Office for National Statistics data and finds children from the most advantaged households benefit from significantly more spending on extra-curricular activities and private tutoring than their poorer peers. The brief also includes the Trust's annual polling on private tuition and new polling on parents and…

  5. Legitimating Lived Curriculum: Towards a Curricular Landscape of Multiplicity.

    Science.gov (United States)

    Aoki, Ted T.

    1993-01-01

    Contrasts the instrumental character of traditional curriculum plans with the retextured curricular landscape inhabited by a hypothetical fifth-grade teacher struggling to help individual students learn. The idea is to teach science as a humanity, so that a privileged technoscientific mindset can be demystified and the multiplicity of human…

  6. Extending Student Knowledge and Interest through Super-Curricular Activities

    Science.gov (United States)

    Zetie, K. P.

    2018-01-01

    Any teacher of physics is likely to consider super-curricular reading as an important strategy for successful students. However, there are many more ways to extend a student's interest in a subject than reading books, and undirected reading (such as providing a long out of date reading list) is not likely to be as helpful as targeted or directed…

  7. Curricular adaptation: alternatives of pedagogical support in the inclusive education

    Directory of Open Access Journals (Sweden)

    Lucia Pereira Leite

    2010-12-01

    Full Text Available The organization of the inclusive education is a slow and complex process, which has the necessity of investments in supports for all the scholar team. Aiming at spreading one of the actions carried out for the promotion of the inclusive educational practices in a municipal education system in a western city in the state of São Paulo, this paperwork has the objective of presenting an elaborated manual of orientations for the implementation of the individual curricular adaptations (ACIs for students who demand special educational necessities.(NEEs. The material was constituted on the basis of three data sets: 1 tabulation of the evaluations of the curricular adaptations already made; 2 the literature review; 3 analysis of the themes which have emerged during case discussion meetings mediated by the researchers with teachers from the Specialized Pedagogical Support Service (SAPE, with teachers and administrators from the common education system and the technical-pedagogical team. The final version of the manual contemplates the theoretical-operational aspects about the themes: flexibility and curricular adequation, inclusive education, definitions of NEEs, how SAPE works; and it finishes with a model proposal of ACI. It is expected that the spreading of this material can subside new curricular propositions for students with deficiency that are very distant from the academic level expected for the current scholar year.

  8. Hamline/3M Project: Liaison for Curricular Change

    Science.gov (United States)

    Rundquist, Andy

    2002-03-01

    This project was designed to catalyze curricular changes to better prepare students for the workplace. Industrial managers provided a list of 16 characteristics valued in the workplace: most were NOT related to science course content. The project formed 5 teams each including 3M professionals and students. Each team developed curricular changes in one of the 16 areas. Team goals were to improve skills in communication, data analysis, business/economics, team problem solving, and culture competency. Curricular changes realized include communication skill activities embodied in science courses and faculty communication teaching skill seminars, self learning tools in data analysis, statistics and model building, a new course developed with assistance from 3M personnel focussing on topics directly related to technological industries, high performance team problem solving training/coaching for faculty and workshops for students and faculty relative to importance of cultural competencies in the workplace, and a new course focusing on culture, team problem solving and conflict resolution in the technical workplace. Process for developing and content of curricular changes will be reported.

  9. Hamline/3M Corp. Project: Liason for Curricular Change*

    Science.gov (United States)

    Artz, Jerry L.

    2002-04-01

    This project was designed to catalyze curricular changes to better prepare students for the workplace. Industrial managers provided a list of 16 characteristics valued in the workplace; most were NOT related to science course content. The project formed 5 teams each including 3M professionals and students. Each team developed curricular changes in one of the 16 areas. Team goals were to improve skills in communication, data analysis, business/economics, team problem solving, and cultural competency. Curricular changes realized include communication skill activities embodied in science courses and faculty communication teaching skill seminars; self learning tools in data analysis, statistics and model building; a new course developed with assistance from 3M personnel focusing on topics directly related to technological industries; high performance team problem solving training/coaching for faculty; workshops for students and faculty relative to importance of cultural competencies in the workplace; and a new course focusing on culture, team problem solving and conflict resolution in the technical workplace. Process for developing and content of curricular changes will be reported. *Thanks to: NSF GOALI CHE-99010782

  10. Extra-Curricular Activities and Academic Performance in Secondary Students

    Science.gov (United States)

    Moriana, Juan Antonio; Alos, Francisco; Alcala, Rocio; Pino, Maria-Jose; Herruzo, Javier; Ruiz, Rosario

    2006-01-01

    Introduction: In this paper we study the possible influence of extra-curricular activities (study-related and/or sports) on academic performance of first- and second-year pupils in "Educacion Secundaria Obligatoria (ESO)" [N.T. seventh- and eighth-graders]. Method: We randomly selected 12 schools in the city (9 public and 3 private), and…

  11. 14 CFR 1253.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Textbooks and curricular material. 1253.455 Section 1253.455 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education...

  12. 6 CFR 17.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Textbooks and curricular material. 17.455 Section 17.455 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education...

  13. 49 CFR 25.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Textbooks and curricular material. 25.455 Section 25.455 Transportation Office of the Secretary of Transportation NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities...

  14. 44 CFR 19.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Textbooks and curricular material. 19.455 Section 19.455 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL...

  15. 31 CFR 28.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Textbooks and curricular material. 28.455 Section 28.455 Money and Finance: Treasury Office of the Secretary of the Treasury NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education...

  16. 45 CFR 618.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Textbooks and curricular material. 618.455 Section 618.455 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Se...

  17. 28 CFR 54.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Textbooks and curricular material. 54.455 Section 54.455 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or...

  18. 22 CFR 229.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Textbooks and curricular material. 229.455 Section 229.455 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activitie...

  19. 13 CFR 113.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Textbooks and curricular material. 113.455 Section 113.455 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NONDISCRIMINATION IN FINANCIAL ASSISTANCE PROGRAMS OF SBA-EFFECTUATION OF POLICIES OF FEDERAL GOVERNMENT AND SBA ADMINISTRATOR Nondiscrimination on the Basis of Se...

  20. 34 CFR 106.42 - Textbooks and curricular material.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Textbooks and curricular material. 106.42 Section 106.42 Education Regulations of the Offices of the Department of Education OFFICE FOR CIVIL RIGHTS, DEPARTMENT OF EDUCATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on...

  1. 22 CFR 146.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Textbooks and curricular material. 146.455 Section 146.455 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities...

  2. 10 CFR 1042.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Textbooks and curricular material. 1042.455 Section 1042.455 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited §...

  3. 38 CFR 23.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Textbooks and curricular material. 23.455 Section 23.455 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the...

  4. 7 CFR 15a.42 - Textbooks and curricular material.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Textbooks and curricular material. 15a.42 Section 15a.42 Agriculture Office of the Secretary of Agriculture EDUCATION PROGRAMS OR ACTIVITIES RECEIVING OR BENEFITTING FROM FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs and Activities Prohibited § 15a.42 Textbooks...

  5. 43 CFR 41.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Textbooks and curricular material. 41.455 Section 41.455 Public Lands: Interior Office of the Secretary of the Interior NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs o...

  6. 36 CFR 1211.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Textbooks and curricular material. 1211.455 Section 1211.455 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION GENERAL RULES NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE...

  7. 45 CFR 2555.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Textbooks and curricular material. 2555.455 Section 2555.455 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE...

  8. 29 CFR 36.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Textbooks and curricular material. 36.455 Section 36.455 Labor Office of the Secretary of Labor NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 36.455 Textbooks...

  9. 40 CFR 5.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Textbooks and curricular material. 5.455 Section 5.455 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education...

  10. 15 CFR 8a.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Textbooks and curricular material. 8a.455 Section 8a.455 Commerce and Foreign Trade Office of the Secretary of Commerce NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education...

  11. 41 CFR 101-4.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Textbooks and curricular material. 101-4.455 Section 101-4.455 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 4-NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES...

  12. 45 CFR 86.42 - Textbooks and curricular material.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Textbooks and curricular material. 86.42 Section 86.42 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education...

  13. 32 CFR 196.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Textbooks and curricular material. 196.455 Section 196.455 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discriminatio...

  14. 10 CFR 5.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Textbooks and curricular material. 5.455 Section 5.455 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 5.455 Textbooks an...

  15. 18 CFR 1317.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Textbooks and curricular material. 1317.455 Section 1317.455 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis o...

  16. 24 CFR 3.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Textbooks and curricular material. 3.455 Section 3.455 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on...

  17. Reflexiones hacia la reformulación curricular

    Directory of Open Access Journals (Sweden)

    Roque González Garzón

    1988-04-01

    Full Text Available RESUMEN En el artículo presenta un marco general  de reflexión sobre la problemática universitaria haciendo énfasis en la necesidad de asumir una nueva concepción curricular, que conduzca  A LA REORIENTACION DEL PROCESO  DE ENSEÑANZA – APRENDIZAJE.

  18. Lessons from industry: one school's transformation toward "lean" curricular governance.

    Science.gov (United States)

    Stratton, Terry D; Rudy, David W; Sauer, Marlene J; Perman, Jay A; Jennings, C Darrell

    2007-04-01

    As medical education grapples with organizational calls for centralized curricular oversight, programs may be compelled to respond by establishing highly vertical, stacked governance structures. Although these models offer discrete advantages over the horizontal, compartmentalized structures they are designed to replace, they pose new challenges to ensuring curricular quality and the educational innovations that drive the curricula. The authors describe a hybrid quality-assurance (QA) governance structure introduced in 2003 at the University of Kentucky College of Medicine (UKCOM) that ensures centralized curricular oversight of the educational product while allowing individualized creative control over the educational process. Based on a Lean production model, this approach draws on industry experiences that strategically separate institutional accountability (management) for a quality curriculum from the decision-making processes required to ensure it (production). In so doing, the authors acknowledge general similarities and key differences between overseeing the manufacture of a complex product versus the education of a physician-emphasizing the structured, sequential, and measurable nature of each process. Further, the authors briefly trace the emergence of quality approaches in manufacturing and discuss the philosophical changes that accompany transition to an institutional governance system that relies on vigorous, robust performance measures to offer continuous feedback on curricular quality.

  19. Re(con)ceiving Young Children's Curricular Performativity

    Science.gov (United States)

    Sellers, Marg

    2010-01-01

    Working (with) Deleuzo-Guattarian philosophical imaginaries opens (to) a multiplicity of possibilities for thinking differently about curriculum, young children and how they perform their curricular understandings. In this article I work (as) rhizome, bringing the imaginaries "becoming" and "milieu" into an early childhood curriculum conversation…

  20. Platinum bioaccumulation by mustard plants (Sinapis alba L.)

    International Nuclear Information System (INIS)

    Hawienczyk, M.; Bystrzejewska-Piotrowska, G.; Kowalska, J.; Asztemborska, M.

    2005-01-01

    The ability of hydroponically cultivated Indian mustard plants (Sinapis alba L.) to accumulate platinum was investigated. The Pt-bioaccumulation in leaves, stem and shoots of plants growing for 2 and 4 weeks at Pt-concentration of 50 and 500 μg/L was compared. The relation between dry and fresh weight was also estimated. Adsorptive stripping voltammetry (AdSV) and mass spectrometry with inductively coupled plasma (ICP-MS) were applied for determination of Pt. Increasing Pt-concentration from 50 to 500 μg/L in the medium causes: (1) reduction of the root tissue hydration level at unchanged modification in aboveground parts of the plants and (2) decrease of the Pt transfer factor (TF) for roots and increase for leaves and stem. Duration of the culture influenced on Pt-accumulation in roots and in aboveground organs of mustard plants. Transfer factor for Pt between 560 and 1600 makes Indian mustard plants one at Pt-hyperaccumulators. Distribution of Pt-bioaccumulation in the plant organs may be useful for biomonitoring of platinum in the environment. (author)

  1. Atividade antimicrobiana de Lippia alba (Mill. N. E. Brown (Verbenaceae

    Directory of Open Access Journals (Sweden)

    Jaciana S. Aguiar

    Full Text Available Lippia alba (Mill. N. E. Brown (Verbenaceae, amplamente distribuída em todo o território brasileiro, é conhecida popularmente como erva cidreira e utilizada na medicina popular como analgésica, febrífuga, antiinflamatória, antigripal e nas afecções hepáticas. Extratos brutos foram preparados a partir de plantas cultivadas, de modo padronizado, em horta medicinal do Laboratório de Fitoterapia da Empresa Pernambucana de Pesquisa Agropecuária (IPA para a verificação da atividade antimicrobiana, in vitro, pelo método de difusão em disco de papel. A concentração inibitória mínima (CIM foi determinada para os extratos que exibiram melhores atividades. Os resultados obtidos mostraram que os extratos clorofórmico, acetônico e etanólico da raiz foram ativos frente a Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Mycobacterium smegmatis, Candida albicans e Monilia sitophila e os extratos hexânicos, etanólicos e metanólicos das folhas inibiram S. aureus, M. luteus, B. subtilis, M. smegmatis e M. sitophila. A menor concentração inibitória (CIM = 31,2 µg/mL, foi obtida para o extrato clorofórmico da raiz frente a B. subtilis e M. luteus.

  2. Multiple paternity in polyandrous barn owls (Tyto alba.

    Directory of Open Access Journals (Sweden)

    Isabelle Henry

    Full Text Available In polyandrous species females produce successive clutches with several males. Female barn owls (Tyto alba often desert their offspring and mate to produce a 2(nd annual brood with a second male. We tested whether copulating during chick rearing at the 1(st annual brood increases the male's likelihood to obtain paternity at the 2(nd annual breeding attempt of his female mate in case she deserts their brood to produce a second brood with a different male. Using molecular paternity analyses we found that 2 out of 26 (8% second annual broods of deserting females contained in total 6 extra-pair young out of 15 nestlings. These young were all sired by the male with whom the female had produced the 1(st annual brood. In contrast, none of the 49 1(st annual breeding attempts (219 offspring and of the 20 2(nd annual breeding attempts (93 offspring of non-deserting females contained extra-pair young. We suggest that female desertion can select male counter-strategies to increase paternity and hence individual fitness. Alternatively, females may copulate with the 1(st male to derive genetic benefits, since he is usually of higher quality than the 2(nd male which is commonly a yearling individual.

  3. EFFECT OF TEMPERATURE ON THE BIOLOGY OF TUBEROLACHNUS SALIGNUS (GMELIN (STERNORRHYNCHA: APHIDIDAE ON (SALIX ALBA

    Directory of Open Access Journals (Sweden)

    Nıhal ÖZDER

    2008-07-01

    Full Text Available The development time, survivoship and reproduction of Tuberolachnus salignus (Gmelin( Lachninae: Lachnini were studied on Salix alba at fi ve constant temperatures (17.5°C, 20°C, 22.5°C, 25°C and 27.5°C . The developmental time of immature stages ranged from 17.00 days at 17.5°C to 12.21 days at 25°C on Salix alba. The total percentage of survivorship of immature stages varied from 50% and 70% 17.5°C -20°C on S. alba. The largest r m valueoccurred with 0.2540 at 20°C on S. alba. The mean generation time of the population ranged from 13.595 days at 22.5°C to 19.60 days at 17.5°C on S. alba. The optimal temperature for Tuberolachnus salignus was 20°C.

  4. Colonization with Arbuscular Mycorrhizal Fungi Promotes the Growth of Morus alba L. Seedlings under Greenhouse Conditions

    Directory of Open Access Journals (Sweden)

    Nan Lu

    2015-03-01

    Full Text Available Morus alba L. is an important tree species planted widely in China because of its economic value. In this report, we investigated the influence of two arbuscular mycorrhizal fungal (AMF species, Glomus mosseae and Glomus intraradices, alone and together, on the growth of M. alba L. seedlings under greenhouse conditions. The growth parameters and physiological performance of M. alba L. seedlings were evaluated 90 days after colonization with the fungi. The growth and physiological performance of M. alba L. seedlings were significantly affected by the AMF species. The mycorrhizal seedlings were taller, had longer roots, more leaves and a greater biomass than the non-mycorrhizae-treated seedlings. In addition, the AMF species-inoculated seedlings had increased root activity and a higher chlorophyll content compared to non-inoculated seedlings. Furthermore, AMF species colonization increased the phosphorus and nitrogen contents of the seedlings. In addition, simultaneous root colonization by the two AMF species did not improve the growth of M. alba L. seedlings compared with inoculation with either species alone. Based on these results, these AMF species may be applicable to mulberry seedling cultivation.

  5. Immunomodulatory activity of methanolic extract of Morus alba Linn. (mulberry) leaves.

    Science.gov (United States)

    Bharani, Shendige Eswara Rao; Asad, Mohammed; Dhamanigi, Sunil Samson; Chandrakala, Gowda Kallenahalli

    2010-01-01

    The leaves of Morus alba Linn. (Family: Moraceae) commonly known as mulberry are mainly used as food for the silkworms and they are sometimes eaten as vegetable or used as cattle fodder in different parts of the world. The effect of Morus alba on the immune system was evaluated by using different experimental models such as carbon clearance test, cyclophosphamide induced neutropenia, neutrophil adhesion test, effect on serum immunoglobulins, mice lethality test and indirect haemagglutination test. Methanolic extract of Morus alba was administered orally at low dose and high dose of 100 mg/kg and 1 g/kg respectively and Ocimum sanctum (100 mg/kg, po) was used as standard drug. Morus alba extract in both doses increased the levels of serum immunoglobulins and prevented the mortality induced by bovine Pasteurella multocida in mice. It also increased the circulating antibody titre in indirect haemagglutination test. On the other hand, it showed significant increase in the phagocytic index in carbon clearance assay, a significant protection against cyclophosphamide induced neutropenia and increased the adhesion of neutrophils in the neutrophil adhesion test. Hence, it was concluded that Morus alba increases both humoral immunity and cell mediated immunity.

  6. The root barks of Morus alba and the flavonoid constituents inhibit airway inflammation.

    Science.gov (United States)

    Lim, Hun Jai; Jin, Hong-Guang; Woo, Eun-Rhan; Lee, Sang Kook; Kim, Hyun Pyo

    2013-08-26

    The root barks of Morus alba have been used in traditional medicine as an anti-inflammatory drug, especially for treating lung inflammatory disorders. To find new alternative agents against airway inflammation and to establish the scientific rationale of the herbal medicine in clinical use, the root barks of Morus alba and its flavonoid constituents were examined for the first time for their pharmacological activity against lung inflammation. For in vivo evaluation, an animal model of lipopolysaccharide-induced airway inflammation in mice was used. An inhibitory action against the production of proinflammatory molecules in lung epithelial cells and lung macrophages was examined. Against lipopolysaccharide-induced airway inflammation, the ethanol extract of the root barks of Morus alba clearly inhibited bronchitis-like symptoms, as determined by TNF-α production, inflammatory cells infiltration and histological observation at 200-400mg/kg/day by oral administration. In addition, Morus alba and their major flavonoid constituents including kuwanone E, kuwanone G and norartocarpanone significantly inhibited IL-6 production in lung epithelial cells (A549) and NO production in lung macrophages (MH-S). Taken together, it is concluded that Morus alba and the major prenylated flavonoid constituents have a potential for new agents to control lung inflammation including bronchitis. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  7. AN EFFECTIVE WAY TO CARRY OUT MASS IN VITRO PROPAGATION OF POTENTILLA ALBA L.

    Directory of Open Access Journals (Sweden)

    L. I. Tikhomirova

    2016-04-01

    Full Text Available Despite the plant’s extensive area of distribution, Potentilla alba L. natural resources are scarce and cannot meet the modern needs of the pharmaceutical industry. Because of the mass preparation of medical raw materials by using P. alba, it entered into the list of rare and endangered species plants of the Red Data Book of the Republic of Belarus. This plant is not represented in the wild flora of Western Siberia, but there is a great need for developing a method for the mass propagation of P. alba using in vitro culture in order to obtain a high-quality planting material. At the explant stage, the technique of the P. alba introduction into in vitro culture is developed. This paper reveals the morphogenetic features of the development of P. alba explants of different types and the regenerative capacity of the tissue culture. At the micropropagation stage, the optimum culture media and the growth conditions for the regenerated plants are selected. At the stage of test-tube plants rooting and transferring them into ex vitro conditions, the most effective means of adaptation to non-sterile conditions in hydroponics are proposed.

  8. Identification and effect of two flavonoids from root bark of Morus alba against Ichthyophthirius multifiliis in grass carp

    Science.gov (United States)

    Morus alba is an important plant for sericulture and has a high medicinal value. In this study, two flavonoids (kuwanons G and O) with antiparasitic activity were isolated from the root bark of M. alba by bioassay-guided fractionation. The chemical structures were determined by pectroscopic analys...

  9. JST Thesaurus Headwords and Synonyms: Sinapis alba [MeCab user dictionary for science technology term[Archive

    Lifescience Database Archive (English)

    Full Text Available MeCab user dictionary for science technology term Sinapis alba 名詞 一般 * * * * シロガラシ シロガラシ シロガラシ Thesaurus2015 200906047820832585 C LS06 UNKNOWN_2 Sinapis alba

  10. Praxis educativa ecopacifista de enriquecimiento curricular: Conceptuacion, diseno y divulgacion

    Science.gov (United States)

    Osorio, Carlos Agustin Muniz

    A general consensus exists that the present worldwide state of the natural environment is in crisis. Tied to this crisis, the social dimension presents a discouraging picture in aspects like violence and poverty. The predominant neoliberal economic system---ecocidal and genocidal---just as the production system that sustains it, affects this crisis. Puerto Rico, in its political and economic relationship with the United States of America, is not exempt of this situation. Education arises as an alternative to transform this reality. Science education has the potential to address these socio-environmental problems in a creative way. From a scientific educational framework, we conceptualized, designed and disseminated diverse approaches and tools that integrate socio-ecological and environmental aspects, as well as issues related to violence, conflict and peace. The central research questions were: At present, what are some of the main characteristics of the social-ecological and environmental global and local (glocal) issues and what relation do they have with formal education?; What is the ethical responsibility of science education when, facing social-ecological and environmental situations and issues concerning peace?; What educational foundations justify the "Praxis Educativa Ecopacifista de Enriquecimiento Curricular" as an alternative to the situations and issues considered?; What didactic tools do we propose?; What curricular design and revision processes do we propose? What dissemination processes do we propose? The nature of our methodology is qualitative and is centered around curricular design. It includes a research-theoretical dimension, a practical-research dimension, and systematizing of learning elements. We emphasize the conceptualization of the theoretical-philosophical and methodological dimensions of the ecopacifist approach and its fundamental principles. We highlight the praxis, integrating creativity, intelligence and talent development

  11. MOVIMIENTOS SOCIALES E INTEGRACIÓN REGIONAL: EL CASO DE LA ARTICULACIÓN DE MOVIMIENTOS SOCIALES HACIA EL ALBA

    Directory of Open Access Journals (Sweden)

    Karla Díaz Martínez

    2013-12-01

    ALBA (the Bolivarian Alliance for the Peoples of Our Americas is a regional integration entity created as an alternative to the US-proposed FTAA (Free Trade Area of the Americas, ALCA in Spanish. ALBA inaugurates a period that has been referred to as post-neoliberal regionalism. Since its origin, ALBA has been accompanied by social movements with an anti-imperialistic and anti-neoliberal stance. ALBA, itself, generated a social entity: the Social Movements Council. However, in a parallel and autonomous way, the social movements created the Articulation of Social Movements toward ALBA. This article describes the characteristics of this entity for social articulation based on theoretical proposals developed in Latin America, and presents a balance of the potentialities and challenges of social movements in Latin America and their incidence in regional integration.

  12. Volcanic styles at Alba Patera, Mars: implications of lava flow morphology to the volcanic history

    International Nuclear Information System (INIS)

    Schneeberger, D.M.; Pieri, D.C.

    1988-01-01

    Alba Patera presents styles of volcanism that are unique to Mars. Its very low profile, large areal extent, unusually long and voluminous lava flows, and circumferential graben make it among Mars' most interesting volcanic features. Clues to Alba's volcanic history are preserved in its morphology and stratigraphy. Understanding the relationship of lava flow morphology to emplacement processes should enable estimates of viscosity, effusion rate, and gross composition to be made. Lava flows, with dimensions considered enormous by terrestrial standards, account for a major portion of the exposed surface of Alba Patera. These flows exhibit a range of morphologies. While most previous works have focused on the planimetric characteristics, attention was drawn to the important morphological attributes, paying particular attention to what the features suggest about the emplacement process

  13. The isolation and identification of endophytic bacteria from mangrove (Sonneratia alba) that produces gelatinase

    Science.gov (United States)

    Nursyam, H.; Prihanto, A. A.; Warasari, N. I.; Saadah, M.; Masrifa, R. E.; Nabila, N. A.; Istiqfarin, N.; Siddiq, I. J.

    2018-04-01

    Gelatinase is an enzyme that hydrolyze gelatin into gelatin hydrolyzate. The purpose of this study was to isolate and to identify endophytic bacteria from Sonneratia alba mangrove which able to produce gelatinase enzyme. Sonneratia alba mangroves was obtained from Bajul Mati Beach, Malang Regency. The samples in this study were, stems, and leaves. Pure cultured bacteria were investigated for its capability for producing gelatinase enzyme by using gelatin media. Best producer would further be analyzed its species using microbact system. Screening process resulted in 3 positive isolates, namely code isolate of R, B, and L. R which was isolate from root of S. alba was the best producer for gelatinase. Identification process with morphology and microbact system revelaed that A. SBM is a Gram-negative bacterium that has a basil cell shape, with a diameter colony of 2.19 mm. Based on the microbact system test carried out, the bacteria is Pseudomonas aeruginosa.

  14. New microsatellite loci for Prosopis alba and P. chilensis (Fabaceae)1

    Science.gov (United States)

    Bessega, Cecilia F.; Pometti, Carolina L.; Miller, Joe T.; Watts, Richard; Saidman, Beatriz O.; Vilardi, Juan C.

    2013-01-01

    • Premise of the study: As only six useful microsatellite loci that exhibit broad cross-amplification are so far available for Prosopis species, it is necessary to develop a larger number of codominant markers for population genetic studies. Simple sequence repeat (SSR) markers obtained for Prosopis species from a 454 pyrosequencing run were optimized and characterized for studies in P. alba and P. chilensis. • Methods and Results: Twelve markers that were successfully amplified showed polymorphism in P. alba and P. chilensis. The number of alleles per locus ranged between two and seven and heterozygosity estimates ranged from 0.2 to 0.8. Most of these loci cross-amplify in P. ruscifolia, P. flexuosa, P. kuntzei, P. glandulosa, and P. pallida. • Conclusions: These loci will enable genetic diversity studies of P. alba and P. chilensis and contribute to fine-scale population structure, indirect estimation of relatedness among individuals, and marker-assisted selection. PMID:25202541

  15. [Study on the fingerprint of Morus alba from different habitats by HPLC].

    Science.gov (United States)

    Chen, Cheng; Li, Hong-Bo; Wang, Liu-Ping; Li, Yun-Rong; Xin, Ning

    2012-12-01

    To establish HPLC fingerprint of Morus alba from different habitats by HPLC and provide basis for its quality control. HPLC analysis was performed on an Agilent XDB C18 Column (4.6 mm x 250 mm, 5 microm), gradient eluted composed of acetonitrile and 0.3% phosphate acid. The column temperature was set at 35 degrees C and the flow rate was 0.5 mL/min. The detective wavelength was 290 nm. The HPLC fingerprint for 10 batches of Morus alba was studied on their similarity. There were twelve common peaks in the fingerprint. The similarity of 7 batches was above 0.9 and the other batches had low similarity. The HPLC fingerprint can be used for quality control of Morus alba with high characteristics and specificity.

  16. La comunidad en transformación. Análisis del cambio en la comunidad del ?Doctorado de Psicología Social Crítica? producido por las TIC?s

    Directory of Open Access Journals (Sweden)

    Maya Ninova

    2005-05-01

    Full Text Available A partir de la definición de comunidad virtual de Rheingold pretendemos hacer un análisis de la comunidad virtual del ?Doctorado de Psicología Social Crítica? (DPSC. La introducción y el uso masivo de las TIC?s (Tecnologías de la Información y de la Comunicación ha generado una transformación muy significativa en la forma de participar en una comunidad como la que encontramos en los DPSC. En esta comunicación pretendemos analizar cómo la introducción de esta nueva forma de relación ha generado cambios en la modalidad de nuestras interacciones y de nuestra identidad como miembros de la comunidad DPSC; para ello contaremos con entrevistas realizadas a los coordinadores de DPSC. Analizaremos la transformación de DPSC a partir de la teoría de P. Lévy.

  17. A REFORMA CURRICULAR EM ALAGOAS E O ENSINO DE SOCIOLOGIA

    Directory of Open Access Journals (Sweden)

    Vanessa do Rêgo Ferreira

    2016-01-01

    Full Text Available O debate sobre o Ensino de Sociologia tem ganhando maior visibilidade nos últimos anos no campo acadêmico brasileiro destacando-se, dentre os temas explorados , a questão do currículo. Visando contribuir para essa discussão apresentamos aqui alguns dados referentes à pesquisa realizada em Alagoas acerca da reforma curricular conduzida nesse Estado, destacando-se como o Ensino de Sociologia aparece em meio desse processo. Metodologicamente partimos tanto de observações realizadas durante o acompanhamento das reuniões que produziram os novos referenciais curriculares, quanto das entrevistas realizadas com os professores de Sociologia que participaram dessas atividades, o coordenador da área e a gerente da Gerência de Organização do Currículo Escolar. Com isso almejamos demonstrar como o processo foi conduzido, bem como apontar os impasses que surgiram e os limites existentes.

  18. WINE ROAD - AN INSTRUMENT FOR THE VALORISATION OF WINE TOURISM POTENTIAL CASE STUDY: ALBA COUNTY VINEYARDS

    OpenAIRE

    UNGUREANU Mihaela

    2015-01-01

    The main aim of this study is to highlight the wine-growing and wine-making potential of Alba County and the way it can be valorised. Alba county has a rich winegrowing and wine-making heritage, a fact which is due to the long-standing tradition of winegrowing on these area, as well as to the characteristics of the natural factors (relief, geology, climate, soil), favourable for obtaining high-quality wines, the reputation of which has been acquired at national and international competitions....

  19. Student-Initiated Sexual Health Selective as a Curricular Tool

    Directory of Open Access Journals (Sweden)

    Katie Johnson, BS

    2015-06-01

    Conclusions: The 1-week SHS was successfully implemented through the teamwork of a medical student and faculty champion. It resulted in more accurate knowledge and more open attitudes toward sexual health among participating medical students. Potential benefits to undergraduate medical educators are reviewed. Johnson K, Rullo J, and Faubion S. Student-initiated sexual health selective as a curricular tool. Sex Med 2015;3:118–127.

  20. A Professionalism Curricular Model to Promote Transformative Learning Among Residents.

    Science.gov (United States)

    Foshee, Cecile M; Mehdi, Ali; Bierer, S Beth; Traboulsi, Elias I; Isaacson, J Harry; Spencer, Abby; Calabrese, Cassandra; Burkey, Brian B

    2017-06-01

    Using the frameworks of transformational learning and situated learning theory, we developed a technology-enhanced professionalism curricular model to build a learning community aimed at promoting residents' self-reflection and self-awareness. The RAPR model had 4 components: (1) R ecognize : elicit awareness; (2) A ppreciate : question assumptions and take multiple perspectives; (3) P ractice : try new/changed perspectives; and (4) R eflect : articulate implications of transformed views on future actions. The authors explored the acceptability and practicality of the RAPR model in teaching professionalism in a residency setting, including how residents and faculty perceive the model, how well residents carry out the curricular activities, and whether these activities support transformational learning. A convenience sample of 52 postgraduate years 1 through 3 internal medicine residents participated in the 10-hour curriculum over 4 weeks. A constructivist approach guided the thematic analysis of residents' written reflections, which were a required curricular task. A total of 94% (49 of 52) of residents participated in 2 implementation periods (January and March 2015). Findings suggested that RAPR has the potential to foster professionalism transformation in 3 domains: (1) attitudinal, with participants reporting they viewed professionalism in a more positive light and felt more empathetic toward patients; (2) behavioral, with residents indicating their ability to listen to patients increased; and (3) cognitive, with residents indicating the discussions improved their ability to reflect, and this helped them create meaning from experiences. Our findings suggest that RAPR offers an acceptable and practical strategy to teach professionalism to residents.

  1. Diretrizes Curriculares de Enfermagem: GOVERNANDO CORPOS DE ENFERMEIRAS

    Directory of Open Access Journals (Sweden)

    Fernanda Niemeyer

    2010-01-01

    Full Text Available Directrices Curriculares objetivan la organización de cursos y carreras para la constitución de identidades profesionales. En este sentido, las Directrices Curriculares Nacionales para la Enseñanza de Grado en Enfermería definen los fundamentos para la formación de enfermeras en el país, apuntando al tipo de conocimiento considerado importante en la profesión. Nos apoyamos en los presupuestos de la obra de Michel Foucault para realizar un análisis textual de los discursos difundidos por las Directrices Curriculares de Enfermería, problematizándolos como una estrategia de gobernar y de hacer subjetivo que actúa sobre los cuerpos de las futuras enfermeras. Las reflexiones apuntan a un documento que se puede ver como un instrumento que pretende normalizar a las alumnas y constituirlas para que se vuelvan enfermeras. Así se define el perfil de la "buena" y de la "mala" profesional, sistematizando los cuerpos y sus actitudes, sin permitirles que piensen y que hagan las cosas de otro modo e instituyendo un "régimen de verdades" que produce cierto tipo de enfermera.

  2. Venezuela e ALBA: regionalismo contra-hegemônico e ensino superior para todos Venezuela and the ALBA: counter-hegemonic regionalism and higher education for all

    Directory of Open Access Journals (Sweden)

    Thomas Muhr

    2010-08-01

    Full Text Available Partindo de um quadro teórico neo-gramsciano crítico à globalização, este artigo aplica a nova teoria do regionalismo (NTR e a teoria do regionalismo regulatório (TRR à sua análise e teorização dos tratados de comércio da Aliança Bolivariana para os Povos da Nossa América (ALBA-TCP como regionalismo contra-hegemônico na América Latina e Caribe (ALC. A ALBA está centrada na ideia de um Socialismo do Século XXI, que, como (inicialmente também a Revolução Bolivariana da Venezuela, substitui a 'vantagem competitiva' pela 'vantagem cooperativa'. Em seu caráter de conjunto de processos multidimensionais e transnacionais a ALBA-TCP opera dentro de/transversalmente a um número de setores e escalas, ao mesmo passo que as transformações estruturais são movidas pela interação de agentes do Estado e agentes não estatais. A política de Educação Superior para Todos (ESPT do governo venezuelano rejeita a agenda neoliberal globalizada de mercadorização, privatização e elitismo e reinvindica educação pública gratuita em todos os níveis como um direito humano fundamental. A ESPT está sendo regionalizado em um espaço educacional emergente da ALBA e assume um papel-chave nos processos de democracia direta e participatória, dos quais a construção popular (bottom-up da contra-hegemonia e a redefinição política e econômica da ALC dependem. Antes de produzir sujeitos empreendedores conformes ao capitalismo global, a ESPT procura formar subjetividades ao longo de valores morais de solidariedade e cooperação. Isso será ilustrado com referência a um estudo etnográfico de caso da Universidade Bolivariana da Venezuela (UBV.This paper employs new regionalism theory and regulatory regionalism theory in its analysis and theorisation of the Bolivarian Alliance for the Peoples of Our America (ALBA as a counter-hegemonic Latin American and Caribbean (LAC regionalism. As (initially the regionalisation of Venezuela's Bolivarian

  3. Student profiling on university co-curricular activities using cluster analysis

    Science.gov (United States)

    Rajenthran, Hemabegai A./P.; Shaharanee, Izwan Nizal Mohd; Jamil, Jastini Mohd.

    2017-11-01

    In higher learning institutions, the co-curricular programs are needed for the graduation besides the standard academic programs. By actively participating in co-curricular, students can attain many of soft skills and proficiencies besides learning and adopting campus environment, community and traditions. Co-curricular activities are implemented by universities mainly for the refinement of the academic achievement along with the social development. This studies aimed to analyse the academic profile of the co-curricular students among uniform units. The main objective of study is to develop a profile of student co-curricular activities in uniform units. Additionally, several variables has been selected to serve as the characteristics for student co-curricular profile. The findings of this study demonstrate the practicality of clustering technique to investigate student's profiles and allow for a better understanding of student's behavior and co-curriculum activities.

  4. LA PALABRA DIBUJADA. ANTONIO FERNÁNDEZ-ALBA, PRIMER Y ÚLTIMO MAESTRO / The drawn word. Antonio Fernández-Alba, first and last master

    Directory of Open Access Journals (Sweden)

    Juan Luis Trillo de Leyva

    2015-05-01

    Full Text Available Távora y Fernández-Alba son figuras de referencia ineludible para quienes quieran hoy investigar el origen contemporáneo de la arquitectura peninsular y, sobre todo, de sus escuelas. Alba fue siempre una guía para los que abordamos una enseñanza alejados del aura que acompañaba a los grandes arquitectos madrileños y barceloneses. Su experimentación didáctica alteró la trayectoria de las escuelas de arquitectura españolas. Introdujo la cultura contemporánea en la universidad como si se tratara de una segunda naturaleza, de un nuevo estrato territorial de los proyectos, manteniendo al hombre como objeto central y destinatario de todo proceso proyectual. En época de virtualidad y representación automatizada, nada más adecuado que la revisión de los dibujos del maestro Fernández-Alba. Dibujos que requieren ser proyectados, pensados, antes que ejecutados, “proyectos de proyectos”, una especie de tautología que rige la mente del poeta en su continua reducción, compresión o destilación, gota a gota, del mundo real, del universo y la palabra.

  5. Cytotoxic and Antimicrobial Constituents from the Essential Oil of Lippia alba (Verbenaceae).

    Science.gov (United States)

    Santos, Nara O Dos; Pascon, Renata C; Vallim, Marcelo A; Figueiredo, Carlos R; Soares, Marisi G; Lago, João Henrique G; Sartorelli, Patricia

    2016-08-12

    Backgroud: Lippia alba (Verbenaceae) is a plant widely used in folk medicine to treat various diseases. The present work deals with the chemical composition of the crude essential oil extracted from leaves of L. alba and evaluation of its antimicrobial and cytotoxic activities. Methods: Leaves of L. alba were extracted by hydrodistillation and analyzed by gas chromatography/mass spectrometry (GC/MS) as well as by nuclear magnetic resonance (NMR) spectroscopy. Cytotoxic and antimicrobial activities of crude essential oil were evaluated in vitro using MTT and broth microdilution assays, respectively. Results: Chemical analysis afforded the identification of 39 substances corresponding to 99.45% of the total oil composition. Concerning the main compounds, monoterpenes nerol/geraniol and citral correspond to approximately 50% of crude oil. The cytotoxic activity of obtained essential oil against several tumor cell lines showed IC 50 values ranging from 45 to 64 µg/mL for B16F10Nex2 (murine melanoma) and A549 (human lung adenocarcinoma). In the antimicrobial assay, was observed that all tested yeast strains, except C. albicans , were sensitive to crude essential oil. MIC values were two to four-folds lower than those determined to bacterial strains. Conclusion: Analysis of chemical composition of essential oils from leaves of L. alba suggested a new chemotype nerol/geraniol and citral. Based in biological evidences, a possible application for studied oil as an antifungal in medicine, as well as in agriculture, is described.

  6. Lawsonia inermis L. Syn. L. alba LamK. (Mehndi or Henna Hindi) of ...

    Indian Academy of Sciences (India)

    Lawsonia inermis L. Syn. L. alba. LamK. (Mehndi or Henna Hindi) of. Lythraceae is a small-sized and much branched tree which is largely cultivated and groomed in the form of hedges. Flowers are white or rose-coloured, fragrant and borne on pyramidal bunches. Fruits bear numerous seeds. Hair dye is prepared from the ...

  7. Natural Durability of Citharexylum spinosum and Morus alba Woods Against Three Mold Fungi

    Directory of Open Access Journals (Sweden)

    Maisa M. A. Mansour

    2015-07-01

    Full Text Available The natural durability of wood to mold fungi was tested under laboratory conditions with locally sourced Citharexylum spinosum and Morus alba woods. The mold fungi were Penicillium selerotigenum, Paecilomyces variotii, and Aspergillus niger. Changes in surface elemental composition were evaluated with energy dispersive X-ray spectroscopy (EDX and the biodeterioration of wood surfaces by scanning electron microscope (SEM. The C peak element of C. spinosum wood was affected significantly (P = 0.0004 and decreased from 49.91% in the control specimens to 47%, 40.1%, and 40% with P. selerotigenum, A. niger, and P. variotii, respectively. Also, the C peak element of M. alba heartwood significantly decreased (P < 0.0001 from 51.33% in the control specimens to 41.49%, 45.66%, and 43.66% in wood inoculated with A. niger, P. variotii, and P. selerotigenum, respectively. The elements Al and Cu were observed in high percentages with M. alba heartwood inoculated by P. variotii. The methanol extract from M. alba heartwood showed good inhibition against the growth of A. niger at a concentration of 32 μg/mL, and the methanol extract from C. spinosum wood showed remarkable inhibition against the growth of P. variotii at a concentration of 8 μg/mL. The results of this study clearly showed the changes that occur in wood samples as a result of fungal infestation.

  8. Alcoholic Extract of Eclipta alba Shows In Vitro Antioxidant and Anticancer Activity without Exhibiting Toxicological Effects

    Directory of Open Access Journals (Sweden)

    Navneet Kumar Yadav

    2017-01-01

    Full Text Available As per WHO estimates, 80% of people around the world use medicinal plants for the cure and prevention of various diseases including cancer owing to their easy availability and cost effectiveness. Eclipta alba has long been used in Ayurveda to treat liver diseases, eye ailments, and hair related disorders. The promising medicinal value of E. alba prompted us to study the antioxidant, nontoxic, and anticancer potential of its alcoholic extract. In the current study, we evaluated the in vitro cytotoxic and antioxidant effect of the alcoholic extract of Eclipta alba (AEEA in multiple cancer cell lines along with control. We have also evaluated its effect on different in vivo toxicity parameters. Here, we found that AEEA was found to be most active in most of the cancer cell lines but it significantly induced apoptosis in human breast cancer cell lines by disrupting mitochondrial membrane potential and DNA damage. Moreover, AEEA treatment inhibited migration in both MCF 7 and MDA-MB-231 cells in a dose dependent manner. Further, AEEA possesses robust in vitro antioxidant activity along with high total phenolic and flavonoid contents. In summary, our results indicate that Eclipta alba has enormous potential in complementary and alternative medicine for the treatment of cancer.

  9. Germination and Seed Bank Studies of Macbridea alba (Lamiaceae), a Federally Theatened Plant

    Science.gov (United States)

    Dana Madsen Schulze; John L. Walker; Timothy P. Spira

    2002-01-01

    Macbridea alba (Lamiaceae) is a Federally threatened plant endemic to Florida. Seedlings are rarely observed in natural populations, but seed production has been documented. We assessed the germinability of dry-stored seeds and of experimentally buried seeds, and sampled soil to detect a persistent seed bank.More than 20% of recorded seeds...

  10. la distruzione dell'esperienza in quaderno proibito di alba de cés

    African Journals Online (AJOL)

    User

    the main works of Alba de Cespedes, Quaderno proibito. I will show how the .... un'opera abbastanza datata, che descrive un tipo di società e un mondo ... padre: romanzo sportivo nel 1935; Prigionie nel 1936; Concerto: racconti nel 1937). A.

  11. The root anchorage ability of Salix alba var. tristis using a pull-out test

    African Journals Online (AJOL)

    user

    2011-11-21

    Nov 21, 2011 ... In the last few years, Beijing Forestry University (China) and the University of Natural Resources and applied Life. Sciences (Austria) have examined the suitabilities and capabilities of soil bioengineering techniques under the local condition of Beijing. One of the plant species used was Salix alba var. tristis.

  12. Wood Anatomical Structure of Morus alba L. and Morus nigra L., Native to Iran

    Directory of Open Access Journals (Sweden)

    Elham KARAMI

    2010-12-01

    Full Text Available Iran is a wast country with many different tree species. Among those there are two species of Morus genus including alba and nigra. Since long time ago, white mulberry�s wood (Morus alba has been used for making musical instruments especially bowl shaped instruments in Iran.. In contrast, black mulberry�s wood (Morus nigra has never been used for these types of applications. In order to investigate the possible replacement choices, this study has been carried out to investigate the anatomical differences and similarities between these two species. Wood samples of the two species have been collected from same site and microsections for light microscopic studies and maceration samples have been prepared. The anatomical characteristics were studied according to the IAWA List of Hardwoods. The most important similarities between them are: vessel solitary in short radial multiples or irregular clusters, fiber nonseptate, rays uniseriate and multiseriate type, paratracheal parenchyma, varying from vasicentric to aliform confluent, apotracheal as marginal bands, Rhombic crystals present in rays and sometimes in parenchyma. The main differences are: semi-ring porous distribution of vessels in M. alba, fewer number of vessels and presence of aliform parenchyma in M. nigra. Taking these results into consideration, the most important features of both species are similar and it could be recommended to use the nigra species as well as the alba for making musical instruments.

  13. Novel and cross-species microsatellite markers for parentage analysis in Sanderling Calidris alba

    NARCIS (Netherlands)

    Luttikhuizen, Pieternella C.; Bol, Anneke; Witte, Harry; van Bleijswijk, Judith; Haddrath, Oliver; Baker, Allan J.; Piersma, Theunis; Reneerkens, Jeroen

    We isolated and tested six novel microsatellite loci in Sanderling (Calidris alba) from Greenland for paternity analyses. In addition, we tested 11 already published microsatellite markers which were originally developed for the congeneric species, the Pectoral Sandpiper (C. melanotos). All loci

  14. Syringa oblata Lindl var. alba as a source of oleuropein and related compounds

    NARCIS (Netherlands)

    Nenadis, N.; Vervoort, J.J.M.; Boeren, J.A.; Tsimidou, M.Z.

    2007-01-01

    The leaf methanol extract of Syringa oblata Lindl var. alba was investigated as a source of oleuropein and related compounds. The extract had a high total phenol content and a radical scavenging activity similar to that of the respective extract from Olea europaea leaves. HPLC-DAD characterisation

  15. Chemical characterization of Lippia alba essential oil: an alternative to control green molds

    Directory of Open Access Journals (Sweden)

    Jasmina Glamočlija

    2011-12-01

    Full Text Available The essential oil of Lippia alba is reported as an antifungal against human pathogenic microorganisms but few articles report its use as an alternative to synthetic fungicides on green mould control. The objective of this study was to determine chemical characteristics of L. alba essential oil and its antifungal activity against green molds as an alternative to synthetic fungicides. Essential oil was extracted by Clevenger hydrodistillation, characterized by GC-MS analysis, and the structure of the main compounds confirmed by ¹H and 13C-NMR spectroscopy. Microdilution assays evaluated the essential oil minimum inhibitory concentration (MIC and minimum fungicidal concentration (MFC. Commercial fungicides Ketoconazole and Bifonazole were used as control. Essential oil yield is of 0.15% and the major components are neral (33.32% and geranial (50.94%. The L. alba essential oil has MIC of 0.300-1.250 mg/mL and MFC of 0.600-1.250 mg/mL. Ketoconazole and Bifonazole show MIC ranging from 0.025-0.500 to 0.100-0.200 mg/mL, and MFC ranging from 0.250-0.100 to 0.200-0.250 mg/mL, respectively. L. alba essential oil is classified as citral type and the results indicate that it is a potential alternative to synthetic fungicides.

  16. Invasive sweetclover (Melilotus alba) impacts native seeding recruitment along floodplains of interior Alaska

    Science.gov (United States)

    Blaine T. Spellman; Tricia L. Wurtz

    2011-01-01

    Sweetclover (Melilotus alba) is a nonnative legume that has formed dense and extensive patches along several rivers in Alaska. Our research objective was to determine if sweetclover impacts recruitment of native seedlings in floodplain habitats. To determine if sweetclover impacted recruitment, we conducted a removal experiment along two rivers in...

  17. Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteins that interact with the translation machinery.

    Directory of Open Access Journals (Sweden)

    Jan Mani

    Full Text Available Trypanosoma brucei and related pathogens transcribe most genes as polycistronic arrays that are subsequently processed into monocistronic mRNAs. Expression is frequently regulated post-transcriptionally by cis-acting elements in the untranslated regions (UTRs. GPEET and EP procyclins are the major surface proteins of procyclic (insect midgut forms of T. brucei. Three regulatory elements common to the 3' UTRs of both mRNAs regulate mRNA turnover and translation. The glycerol-responsive element (GRE is unique to the GPEET 3' UTR and regulates its expression independently from EP. A synthetic RNA encompassing the GRE showed robust sequence-specific interactions with cytoplasmic proteins in electromobility shift assays. This, combined with column chromatography, led to the identification of 3 Alba-domain proteins. RNAi against Alba3 caused a growth phenotype and reduced the levels of Alba1 and Alba2 proteins, indicative of interactions between family members. Tandem-affinity purification and co-immunoprecipitation verified these interactions and also identified Alba4 in sub-stoichiometric amounts. Alba proteins are cytoplasmic and are recruited to starvation granules together with poly(A RNA. Concomitant depletion of all four Alba proteins by RNAi specifically reduced translation of a reporter transcript flanked by the GPEET 3' UTR. Pulldown of tagged Alba proteins confirmed interactions with poly(A binding proteins, ribosomal protein P0 and, in the case of Alba3, the cap-binding protein eIF4E4. In addition, Alba2 and Alba3 partially cosediment with polyribosomes in sucrose gradients. Alba-domain proteins seem to have exhibited great functional plasticity in the course of evolution. First identified as DNA-binding proteins in Archaea, then in association with nuclear RNase MRP/P in yeast and mammalian cells, they were recently described as components of a translationally silent complex containing stage-regulated mRNAs in Plasmodium. Our results are

  18. ALBA, organisation interaméricaine ou vénézuélienne ?

    Directory of Open Access Journals (Sweden)

    Jean-Jacques Kourliandsky

    2011-01-01

    Full Text Available L’«Alliance Bolivarienne des peuples de notre Amérique», ou ALBA, est de toutes les organisations interaméricaines celle dont l’identité est la plus originale. S’affirmant anti-impérialiste elle donne en effet à l’idéologie une place centrale qui commande la coopération entre ses membres. Mais l’ALBA au quotidien diffère-t-elle d’autres organisations d’intégration ? Le lien entre les différents pays qui la composent n’est-il pas au-delà de l’hommage unanime rendu à Bolivar bien davantage celui de pouvoir bénéficier du pétrole vénézuélien à un prix préférentiel ? L’ALBA, comme d’autres institutions latino-américaines, ne répond-elle pas à l’ambition d’un État, en l’occurrence ici le Venezuela, plus qu’à celle de construire un projet collectif pérenne? Ce lien entre le pétrole de son initiateur vénézuélien et l’ALBA, est une garantie pour le présent. Mais l’ALBA survivrait-elle à une alternance politique au Venezuela, ou à une chute des prix du baril affectant le nerf de l’organisation ?

  19. [Analysis of dynamic changes of flavonoids and alkaloids during different drying process of Morus alba leaves].

    Science.gov (United States)

    Bai, Yong-liang; Duan, Jin-ao; Su, Shu-lan; Qian, Ye-fei; Qian, Da-wei; Ouyang, Zhen

    2014-07-01

    To find out dynamic changes of flavonoids and alkaloids in Morus alba leaves by analyzing influence of different drying method and drying degrees, in order to provide evidence for quality evaluation of Morus alba leaves. Different drying methods, programmed temperature methods and constant temperature methods were adopted to dry Morus alba leaves samples respectively. Contents of flavonoids and alkaloids were analyzed by HPLC-PDA and LC-TQ/MS respectively. It's shown obviously that the content of flavonoids were influenced heavily by different drying methods. Methods that suitable for flavonoids were freezing-dried > shade-dried > dried > sun-dried > microwave-dried > infrared-dried; Methods that suitable for alkaloids were freezing-dried > shade-dried > dried > sun-dried > infrared-dried > microwave-dried. The 55 -65 degrees C group was shown to be the lowest in both flavonoids and DNJ while the 85 - 95 degrees C group was shown to be the best for DNJ. For fagomine, the 45 degrees C group was shown to be the lowest concentrations while the 95 - 105 degrees C group was shown to be the highest. Samples with different moisture were shown to be different in content of flavonoids and alkaloids. And samples with 10% moisture contain highest flavonoids while those with 30% - 50% moisture contain lowest flavonoids. Content of DNJ and fagomine raised as moisture decreasing. In addition, the 55 - 65 degrees C group was better than the 95 -105 degrees C one in alkaloids content. The results provide optimal drying methods and condition for drying Morus alba leaves, and foundations for uncovering biochemical transform of Morus alba leaves.

  20. LA EVALUACIÓN CURRICULAR COMO BASE PARA EL PERFECCIONAMIENTO CURRICULAR EN LA CARRERA DE ECONOMÍA

    Directory of Open Access Journals (Sweden)

    Robert Alfredo Alfredo Pilozo Cedeño

    2013-07-01

    Full Text Available El economista del Siglo XXI debe ejercer su profesión en un entorno dinámico y complejo, caracterizado por frecuentes cambios políticos, sociales, culturales y laborales. En tales circunstancias, el profesional de las Ciencias Económicas debe  demostrar las competencias adquiridas en su proceso formativo, a través de la aplicación de sus conocimientos para identificar las problemáticas más frecuentes que se revelan en el funcionamiento de los sistemas económicos – financieros y el diseño de alternativas de solución que no contradigan la asignación de recursos en pos del desarrollo humano, a la vez, que estimulen el eficiente desempeño empresarial. Entre las cualidades inherentes a este profesional está la capacidad de anticiparse a las posibles contradicciones económicas y financieras relevantes para una organización en cualquier situación concreta, así como su preparación para presentar y defender las vías que propone, para facilitar su solución con un sólido fundamento de alineación de estas, con las metas organizacionales y la evaluación actual y futura de los posibles resultados en escenarios diversos. Contar con un perfil de egreso, que se articule con la estructuración de la malla curricular, los programas de asignaturas y los requerimientos sociales hacia el economista en el contexto regional, nacional e internacional es una válida intención que justifica el perfeccionamiento curricular en pos de lograr un proceso formativo pertinente, al definir el perfil de competencias específicas, básicas y transversales que caracterizan el desempeño del economista.PALABRAS CLAVE: perfeccionamiento curricular; evaluación; competenciasTHE CURRICULAR EVALUATION AS BASE FOR THE CURRICULAR IMPROVEMENT IN THE CAREER OF ECONOMYABSTRACTThe Economist of the 21st century must exercise their profession in a dynamic and complex environment characterized by frequent changes of political, social, cultural and labor. In such

  1. Exploring Curricular Transformation to Promote Innovation and Entrepreneurship: An Institutional Case Study

    Science.gov (United States)

    McClure, Kevin R.

    2015-01-01

    Colleges and universities in the United States have developed and implemented a wide array of opportunities for undergraduate students to learn about innovation and entrepreneurship. Drawing upon an institutional case study, this article examines why one public research university initiated and supported curricular and co-curricular offerings in…

  2. Beyond Motivation: Exploring Mathematical Modeling as a Context for Deepening Students' Understandings of Curricular Mathematics

    Science.gov (United States)

    Zbiek, Rose Mary; Conner, Annamarie

    2006-01-01

    Views of mathematical modeling in empirical, expository, and curricular references typically capture a relationship between real-world phenomena and mathematical ideas from the perspective that competence in mathematical modeling is a clear goal of the mathematics curriculum. However, we work within a curricular context in which mathematical…

  3. Curricular Trends and Practices in the High School: A Second Look.

    Science.gov (United States)

    Tubbs, Mary P.; Beane, James A.

    1981-01-01

    In this 1979 replication of a 1974 survey, 234 high school principals provided information on perceived influences on curriculum, groups involved in curricular decision making, and use of 20 curricular arrangements and offerings, such as departmentalization, independent study, competencies, moral education, and unified studies. Five-year trends…

  4. The Effect of Curricular and Extracurricular Activities on University Students' Entrepreneurial Intention and Competences

    Science.gov (United States)

    Arranz, Nieves; Ubierna, Francisco; Arroyabe, Marta. F.; Perez, Carlos; Fernandez de Arroyabe, J. C.

    2017-01-01

    This paper examines the effect of curricular and extracurricular activities on the entrepreneurial motivation and competences of university students. In order to address these issues, the authors have used Ajzen's model of planned behaviour, including curricular and extracurricular activities, analysing their effect on university students'…

  5. An Exploration of the Participation of Kindergarten-Aged Hong Kong Children in Extra Curricular Activities

    Science.gov (United States)

    Lau, Eva Yi Hung; Cheng, Doris Pui Wah

    2016-01-01

    In this study, we used a mixed-methods research design to investigate the extra curricular participation of kindergarten-aged Hong Kong children, based on reports provided by 1260 parents, and parents' perceptions of their children's extra curricular participation, through nine individual interviews. The results of the survey indicated that…

  6. Extra-Curricular Social Studies in an Open Air History Museum

    Science.gov (United States)

    Morris, Ronald Vaughan

    2008-01-01

    This article discusses extra-curricular social studies in an Open Air History Museum. Open Air History Museum, Conner Prairie Interpretive Park in Fishers, Indiana, is a cultural institution that encourages and supports talented students as they participate in an extra-curricular program. Ten-to sixteen-year-old youths "apply for jobs"…

  7. Curricular and Instructional Differentiation in Magnet Schools: Market Driven or Institutionally Entrenched?

    Science.gov (United States)

    Hausman, Charles

    This paper examines market and institutional perspectives to provide a framework for exploring curricular and instructional differentiation in school choice. It reviews previous research on the relationship between school choice and curricular, and instructional differentiation and innovation, and explores the extent to which principals and…

  8. A New Approach to Authoring Interactive Curricular Material

    Science.gov (United States)

    Christian, Wolfgang

    1999-11-01

    A persistent problem facing educational software authors is that programming has no top. In other words, the moment a program is finished a potential user will ask for an enhancement or modification to use the program in a new context. Scriptable general-purpose applets, such as Physlets, provide a partial solution since the user can specify the applet's behavior provided that the applet author has anticipated the need. But this is not enough. Curriculum authors usually want to process the data and to present it in various formats. Over the past year the functionality of Physlets has been greatly extended through the use of inter-applet communication. This makes it possible to use a modular object-oriented approach for the design of interactive curricular material. Many Physlets, including Animator, EField, BField, and Faraday, are now capable of generating data in response to an internal clock or in response to user actions. This data can then be passed to a bar graph, a table of numeric values, or an x-y graph using one line of JavaScript to establish the communication link. This technique is very flexible since the code to process and present the data is written in an interpreted runtime environment. Furthermore, web servers can customize the code as the document is being delivered for applications such as testing and online homework. Examples of interactive curricular material that makes use of these techniques will be presented.

  9. Oxidative stability of cnicken thigh meat after treatment of abies alba essential oil

    Directory of Open Access Journals (Sweden)

    Adriana Pavelková

    2015-12-01

    Full Text Available In the present work, the effect of the Abies alba essential oil in two different concentrations on oxidative stability of chicken thigh muscles during chilled storage was investigated. In the experiment were chickens of hybrid combination Cobb 500 after 42 days of the fattening period slaughtered.  All the broiler chickens were fed with the same feed mixtures and were kept under the same conditions. The feed mixtures were produced without any antibiotic preparations and coccidiostatics. After slaughtering was dissection obtained fresh chicken thigh with skin from left half-carcass which were divided into five groups (n = 5: C - control air-packaged group; A1 - vacuum-packaged experimental group; A2 - vacuum-packaged experimental group with ethylenediaminetetraacetic acid (EDTA solution 1.50% w/w; A3 - vacuum-packaged experimental group with Abies alba oil 0.10% v/w and A4 - vacuum-packaged experimental group with Abies alba oil 0.20% v/w. The Abies alba essential oil was applicate on ground chicken things and immediately after dipping, each sample was packaged using a vacuum packaging machine and storage in refrigerate at 4 ±0.5 °C. Thiobarbituric acid (TBA value expressed in number of malondialdehyde was measured in the process of first storage day of 1st, 4th, 8th, 12th and 16th day after slaughtering and expressed on the amount of malondialdehyde (MDA in 1 kg sample. The treatments of chicken things with Abies alba essential oil show statistically significant differences between all testing groups and control group, where higher average value of MDA measured in thigh muscle of broiler chickens was in samples of control group (0.4380 mg.kg-1 compared to experimental groups A1 (0.124 mg.kg-1, A2 (0.086 mg.kg-1, A3 (0.082 mg.kg-1 and A4 (0.077 mg.kg-1 after 16-day of chilled storage. Experiment results show that the treatment of chicken thigh with Abies alba essential oil positively influenced on the reduction of oxidative processes in thigh

  10. [Evaluate drug interaction of multi-components in Morus alba leaves based on α-glucosidase inhibitory activity].

    Science.gov (United States)

    Ji, Tao; Su, Shu-Lan; Guo, Sheng; Qian, Da-Wei; Ouyang, Zhen; Duan, Jin-Ao

    2016-06-01

    Column chromatography was used for enrichment and separation of flavonoids, alkaloids and polysaccharides from the extracts of Morus alba leaves; glucose oxidase method was used with sucrose as the substrate to evaluate the multi-components of M. alba leaves in α-glucosidase inhibitory models; isobole method, Chou-Talalay combination index analysis and isobolographic analysis were used to evaluate the interaction effects and dose-effect characteristics of two components, providing scientific basis for revealing the hpyerglycemic mechanism of M. alba leaves. The components analysis showed that flavonoid content was 5.3%; organic phenolic acids content was 10.8%; DNJ content was 39.4%; and polysaccharide content was 18.9%. Activity evaluation results demonstrated that flavonoids, alkaloids and polysaccharides of M. alba leaves had significant inhibitory effects on α-glucosidase, and the inhibitory rate was increased with the increasing concentration. Alkaloids showed most significant inhibitory effects among these three components. Both compatibility of alkaloids and flavonoids, and the compatibility of alkaloids and polysaccharides demonstrated synergistic effects, but the compatibility of flavonoids and polysaccharides showed no obvious synergistic effects. The results have confirmed the interaction of multi-components from M. alba leaves to regulate blood sugar, and provided scientific basis for revealing hpyerglycemic effectiveness and mechanism of the multi-components from M. alba leaves. Copyright© by the Chinese Pharmaceutical Association.

  11. An anticipatory quality improvement process for curricular reform.

    Science.gov (United States)

    Hollander, Harry; Loeser, Helen; Irby, David

    2002-09-01

    Over half of American medical schools are currently engaged in significant curricular reform. Traditionally, evaluation of the efficacy of educational changes has occurred well after the implementation of curricular reform, resulting in significant time elapsed before modification of goals and content can be accomplished. We were interested in establishing a process by which a new curriculum could be reviewed and refined before its actual introduction. The University of California, San Francisco (UCSF) School of Medicine embarked upon a new curriculum for the class entering in September 2001. Two separate committees coordinated plans for curricular change. The Essential Core Steering Committee was responsible for the first two years of training, and the Integrated Clinical Steering Committee guided the development of the third-and fourth-year curriculum. Both groups operated under guidelines of curricular reform, established by the School's Committee on Curriculum and Educational Policy, that emphasized integration of basic, clinical, and social sciences; longitudinal inclusion of themes such as behavior, culture, and ethics; use of clinical cases in teaching; and inclusion of small-group and problem-based learning. In early 2001, the deans of education and curricular affairs appointed an ad hoc committee to examine the status of the first-year curriculum, which had been entirely reformulated into a series of new multidisciplinary block courses. This ad hoc committee was composed of students and clinical faculty members who had not been substantially involved in the detailed planning of the blocks. The charge to the committee was to critique the progress of individual courses, and the first year as a whole, in meeting the goals outlined above, and to make recommendations for improving the preparation of students for the clinical years. To accomplish these goals, the committee reviewed background planning documents; interviewed each course director using a

  12. Norma ISO 690:2010 [Doctorado. 2015

    OpenAIRE

    Biblioteca Universitaria

    2015-01-01

    Mediante el estudio de este tema aprenderás a gestionar adecuadamente tu bibliografía adquiriendo una serie de competencias que te permitirán: - Actuar de manera responsable, ética y legal en el uso de la información empleada para realizar un trabajo académico. - Identificar el estilo de cita más adecuado para cada disciplina científica. - Identificar correctamente y elaborar las referencias bibliográficas correspondientes a distintos tipos de documentos, de acuerdo con la norma ISO 690:2010....

  13. Norma ISO 690:2010 [Doctorado. 2017

    OpenAIRE

    Biblioteca Universitaria

    2017-01-01

    Mediante el estudio de este tema aprenderás a gestionar adecuadamente tu bibliografía adquiriendo una serie de competencias que te permitirán: - Actuar de manera responsable, ética y legal en el uso de la información empleada para realizar un trabajo académico. - Identificar el estilo de cita más adecuado para cada disciplina científica. - Identificar correctamente y elaborar las referencias bibliográficas correspondientes a distintos tipos de documentos, de acuerdo con la norma ISO 690:2010....

  14. Norma ISO 690:2010 [Doctorado. 2014

    OpenAIRE

    Biblioteca Universitaria

    2014-01-01

    Mediante el estudio de este tema aprenderás a gestionar adecuadamente tu bibliografía adquiriendo una serie de competencias que te permitirán: - Actuar de manera responsable, ética y legal en el uso de la información empleada para realizar un trabajo académico. - Identificar el estilo de cita más adecuado para cada disciplina científica. - Identificar correctamente y elaborar las referencias bibliográficas correspondientes a distintos tipos de documentos, de acuerdo con la norma ISO 690:2010....

  15. HYSTOLOGICAL-FUNCTIONAL SPECIFITY OF NYMPHAEA ALBA L.VEGETATIVE ORGANS

    Directory of Open Access Journals (Sweden)

    Sidorova V. N.

    2012-11-01

    Full Text Available Nymphaea alba L. belongs to aerohydrophytes and has all typical features of such ecological group. We found out the followings anatomic and functional features which are adaptation to the surplus of water: 1 formation of astrosklereid, which are the mechanical fabrics; 2 presence of large intercells which serve as plant fixation; 3 absence of stomas on the lower side of leaf and submarine organs that alterate the interchange of gases. The mycrochemical ash analysis of plant vegetative organs showed the presence of crystals of strontium, sulfur, potassium, ferrum, calcium, sodium, nitrogen, which vary by accumulation, form, and sizes, in vegetative organs (leaf, root and stem. We proved that quantitative, anatomical, and physiological peculiarities of Nymphaea alba L. vegetative organs uncover the mechanism of adaptation of aerohydrophytes to environment factors. The adaptative mechanisms of plant and their functioning are changed under influence of surplus of water.

  16. Derivation of uranium residual radioactive material guidelines for the former Alba Craft Laboratory site, Oxford, Ohio

    International Nuclear Information System (INIS)

    Nimmagadda, M.; Faillace, E.; Yu, C.

    1994-01-01

    Residual radioactive material guidelines for uranium were derived for the former Alba Craft Laboratory site in Oxford, Ohio. This site has been identified for remedial action under the Formerly Utilized Sites Remedial Action Program (FUSRAP) of the US Department of Energy (DOE). Single nuclide and total uranium guidelines were derived on the basis of the requirement that the 50-year committed effective dose equivalent to a hypothetical individual who lives or works in the immediate vicinity of the former Alba Craft Laboratory site should not exceed a dose of 30 mrem/yr following remedial action for the current use and likely future use scenarios or a dose of 100 mrem/yr for less likely future use scenarios (Yu et al. 1993). The DOE residual radioactive material guideline computer code, RESRAD, which implements the methodology described in the DOE manual for implementing residual radioactive material guidelines, was used in this evaluation

  17. Pharmacognostical Standardization of Upodika- Basella alba L.: An Important Ayurvedic Antidiabetic Plant

    Directory of Open Access Journals (Sweden)

    T R Shantha

    2016-01-01

    Full Text Available Objective: To establish the pharmacognostic standards for the correct identification and standardization of an important Antidiabetic plant described in Ayurveda. Materials and Methods: Standardization was carried out on the leaf and stem of Basella alba L. with the help of the macro-morphological, microscopic, physicochemical and qualitative phytochemical studies. Results: Several specific characters were identified viz. clustered calcium oxalate crystals in the cortex region, absence of trichomes, succulent, thick, mucilaginous, fibrous stem. Rubiaceous type of stomata on both sides of the leaf. Quantitative microscopy along with physicochemical and qualitative phytochemical analysis were also established. Conclusion: The pharmacognostic standards could serve as the reference for the proper identification of the Basella alba L. which is an important anti-diabetic plant described in Ayurveda.

  18. Three New Isoprenylated Flavonoids from the Root Bark of Morus alba.

    Science.gov (United States)

    Jung, Jae-Woo; Park, Ji-Hae; Lee, Yeong-Geun; Seo, Kyeong-Hwa; Oh, Eun-Ji; Lee, Dae-Young; Lim, Dong-Wook; Han, Daeseok; Baek, Nam-In

    2016-08-24

    Phytochemical investigation of the root bark of Morus alba has led to the isolation and identification of three new isoprenylated flavonoids, namely sanggenon U (1), sanggenon V (2), and sanggenon W (3), along with four known isoprenylated flavonoids: euchrenone a₇ (4), sanggenon J (5), kuwanon E (6), and kuwanon S (7). All compounds were isolated by repeated silica gel (SiO₂), octadecyl SiO₂ (ODS), and Sephadex LH-20 open column chromatography. The structure of the compounds were determined based on spectroscopic analyses, including nuclear magnetic resonance (NMR), mass spectrometry (MS), circular dichroism (CD), and infrared (IR). In addition, compounds 1-4 were isolated for the first time from the root bark of M. alba in this study.

  19. A new flavonoid glycoside from the root bark of Morus alba L.

    Science.gov (United States)

    Park, Ji-Hae; Jung, Ye-Jin; Jung, Jae-Woo; Shrestha, Sabina; Lim, Dong Wook; Han, Daeseok; Baek, Nam-In

    2014-01-01

    A new guibourtinidol glycoside, (2R,3S)-guibourtinidol-3-O-α-d-apiofuranosyl-(1 → 6)-O-β-D-glucopyranoside (1), and three known compounds, quercetin 7-O-β-D-glucopyranoside (2), syringaresinol-4-O-β-D-glucopyranoside (3) and dehydrodiconiferyl alcohol 4,9'-di-O-β-D-glucopyranoside (4), were isolated from the root bark of Morus alba L. through repeated silica gel, octadecyl silica gel and Sephadex LH-20 column chromatography for the n-BuOH fraction. The chemical structure of the compounds was elucidated based on MS, infrared, 1D and 2D NMR spectroscopic data. Compounds 2-4 were also isolated for the first time from the root bark of M. alba L. in this study.

  20. Solvent Effect on Antioxidant Activity and Total Phenolic Content of Betula alba and Convolvulus arvensi

    OpenAIRE

    Mohd Azman A. Nurul; Husni Shafik; Almajano P. Maria; Gallego G. Maria

    2013-01-01

    The potential of using herbal Betula alba (BA) and Convolvulus arvensis (CA) as a natural antioxidant for food applications were investigated. Each plant extract was prepared by using pure ethanol, different concentration of ethanol aqueous solutions, including 50% and 75%, 50% methanol aqueous and water. Total phenolic content (TPC) was determined using Folin–Ciocalteau method and antioxidant activity were analyzed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals, trolox equivalent antioxida...

  1. Insights into some physiological and biochemical responses of Populus alba and Populus nigra to lead contamination

    Directory of Open Access Journals (Sweden)

    Elham Etemadi

    2016-12-01

    Full Text Available The effects of lead (PbCl2 increment, under hydroponic conditions up to 15, 45 and 90 mg/l in presence of EDTA, on some physiological and biochemical traits of one year old saplings of P. nigra and P. alba, were investigated. Six weeks after establishing in target concentration, the amount of lead, biomass, water, soluble sugars, proline, electrolyte leakage, malondialdehyde, and pigments were assessed in different organs. The results revealed that with increasing lead concentration in culture medium in the studied period, the amount of lead in saplings increased, but no effect was observed on their biomass. In both species the magnitude of lead accumulation in root was higher than leaf. P. nigra had more water and less soluble sugars than P. alba. The concentration of soluble sugars increased up to 1.5 times with lead increment in both species, but proline content increased only in P. nigra up to 2 times and remained constant in P. alba. Elevation of electrolyte leakage in saplings of P. nigra in excess lead treatment was accompanied by no change in malondialdehyde content. Concentrations of pigments were not affected by lead, and only the ratio of chlorophyll a to b in P. nigra increased in high lead concentration. In general both species accumulated high extent of lead in their organs. But it seems that P. nigra, at least with respect of enhancing plasma membrane permeability, increasing proline and the ratio of chlorophyll a to b, was more sensitive to this toxic metal in compare with P. alba.

  2. Epicuticular wax on stomata of damaged silver fir trees (Abies alba Mili.)

    OpenAIRE

    Tomislav Bačić; Ljiljana Krstin; Jadranka Roša; Željko Popović

    2011-01-01

    Condition of epistomatal wax on the abaxial surface of the current and previous-year needles of damaged silver fir trees (Abies alba Mill.), both from the polluted Risnjak and "clean" Donja Dobra sites in Gorski Kotar region, both influenced by pollutants coming from Europe, during two years, three times a year, were examined with Scanning Electron Microscope. In the course of time the wax tubules on the epistomatal rims of stomata in polluted, but also in "clean" needles surface, become fuse...

  3. El ALBA y los “anti”. Un proyecto de integración alternativo latinoamericano

    Directory of Open Access Journals (Sweden)

    Adolfo A. Abadía

    2014-12-01

    Full Text Available Reseña del libro:Bagley, B. M. y Defort M. (Eds. (2014. ¿La hegemonía norteamericana en declive? El desafío del ALBA y la nueva integración latinoamericana del siglo XXI. ColecciónEl sur es cielo roto. Cali, Colombia: Facultad de Derecho y Ciencias Sociales,Universidad Icesi. 640 pp.

  4. Anti-stress effect of ethyl acetate soluble fraction of Morus alba in chronic restraint stress.

    Science.gov (United States)

    Nade, Vandana S; Yadav, Adhikrao V

    2010-09-01

    Restraint stress is a well-known method to induce chronic stress which leads to alterations in various behavioral and biochemical parameters. The present work was designed to study anti-stress effects of Morus alba in chronic restraint stress (RS)-induced perturbations in behavioral, biochemical and brain oxidative stress status. The stress was produced by restraining the animals inside an adjustable cylindrical plastic tube for 3 h once daily for ten consecutive days. The ethyl acetate soluble fraction of Morus alba (EASF) 25, 50, 100 mg/kg and diazepam (1 mg/kg) per day was administered 60 min prior to the stress procedure. The behavioral and biochemical parameters such as open field, cognitive dysfunction; leucocytes count; blood glucose and corticosteroid levels were determined. On day 10, the rats were sacrificed and biochemical assessment of superoxide dismutase (SOD), lipid peroxidation (LPO), catalase (CAT), and glutathione reductase (GSH) in whole rat brain were performed. Chronic restraint stress produced cognitive dysfunction, altered behavioral parameters, increased leucocytes count, SOD, LPO, glucose and corticosterone levels, with concomitant decrease in CAT and GSH activities. Gastric ulceration, adrenal gland and spleen weights were also used as the stress indices. All these RS induced perturbations were attenuated by EASF of Morus alba. The results of the study suggest that in addition to its classically established pharmacological activities, the plant also has immense potential as an anti-stress agent of great therapeutic relevance. This study indicates the beneficial role of Morus alba for the treatment of oxidative stress-induced disorders.

  5. Two new phenolic constituents from the root bark of Morus alba L. and their cardioprotective activity.

    Science.gov (United States)

    Cao, Yan-Gang; Zheng, Xiao-Ke; Yang, Fang-Fang; Li, Fang; Qi, Man; Zhang, Yan-Li; Zhao, Xuan; Kuang, Hai-Xue; Feng, Wei-Sheng

    2018-02-01

    A new biphenyl-furocoumarin, named morescoumarin A (1), and a new prenylated flavanone, named morflavanone A (2) were isolated from the root bark of Morus alba L., together with four known compounds (3-6). Their structures were determined by extensive spectroscopic analyses and comparison with literature data. The cardioprotective effects of these compounds against doxorubicin-induced cell death were evaluated by MTT method.

  6. A 28-Day Repeated Dose Toxicological Study of an Aqueous Extract of Morus Alba L.

    Science.gov (United States)

    Marx, Tennille K; Glávits, Róbert; Endres, John R; Palmer, Philip A; Clewell, Amy E; Murbach, Timothy S; Hirka, Gábor; Pasics, Ilona

    2016-11-01

    Morus alba L. (white mulberry) leaves are one of the oldest recognized traditional Chinese medicines. More recently, M alba leaves and their constituents, particularly iminosugars (or azasugars), have garnered attention for their ability to maintain normal blood glucose concentrations, an effect identified in both animal studies and human clinical trials. Reducose (Phynova Group Limited) is a commercial water-soluble extract of M alba leaves standardized to 5% 1-deoxynojirimycin (DNJ), an iminosugar with α-glucosidase inhibition properties. Although there is an extensive history of consumption of M alba leaves by humans and animals worldwide, suggesting that the leaves and their extracts have a relatively good safety profile, we are unaware of safety assessments on an extract containing a higher amount of DNJ than that occurs naturally. The current 28-day repeated dose oral toxicity study in rats, conducted according to Organisation for Economic Co-operation and Development guidelines, was carried out to assess the safety of Reducose. Male and female Hsd.Han Wistar rats (4 groups of 10 animals/sex) were administered Reducose via gavage at doses of 0, 1,000, 2,000 and 4,000 mg/kg body weight (bw)/d. No treatment-related mortality or adverse effects (per clinical observations, body weight/weight gain, food consumption, ophthalmoscopy, clinical pathology, gross pathology, organ weights, or histopathology) were observed, and no target organs were identified. The no observed adverse effect level was determined to be 4,000 mg/kg bw/d for both male and female rats, the highest dose tested. © The Author(s) 2016.

  7. Terpenoid Profile of Artemisia Alba is Related to Endogenous Cytokinins in Vitro

    Czech Academy of Sciences Publication Activity Database

    Krumova, S.; Motyka, Václav; Dobrev, Petre; Todorova, M.; Trendafilova, A.; Evstatieva, L.; Danova, K.

    2013-01-01

    Roč. 19, č. 2 (2013), s. 26-30 ISSN 1310-0351 R&D Projects: GA ČR(CZ) GAP506/11/0774 Institutional research plan: CEZ:AV0Z50380511 Keywords : Artemisia alba * in vitro * endogenous cytokinins Subject RIV: EF - Botanics Impact factor: 0.136, year: 2012 http://www.agrojournal.org/19/02-06s.pdf

  8. Pollos cuello desnudo alimentados con harina de Morus alba y Cajanus cajan

    Directory of Open Access Journals (Sweden)

    Tito Solís-Barros

    2017-12-01

    Full Text Available El objetivo de la investigación fue estudiar el comportamiento productivo de pollos cuello desnudo heterocigotos que se alimentaron con harina de hojas de Morus alba y granos de Cajanus cajan tostados a 120 ºC por 12 min, se utilizaron 144 pollos sexados de la estirpe T451N de 1 a 90 d de edad. Se distribuyeron según diseño de bloques al azar, en tres tratamientos, 48 pollos por tratamiento repartidos en ocho réplicas. Fueron criados en piso, en instalaciones rústicas. Se evaluaron indicadores productivos como el consumo de alimento, ganancia de peso promedio diario, conversión alimentaria y la eficiencia en el uso de los nutrientes. Los tratamientos fueron: T1=Control, T2=5% Cajanus cajan y 3% Morus alba y T3=3% C. cajan y 5% M. alba. El control consumió maíz y soya, como dieta base. La mayor ingestión de alimento (p

  9. WINE ROAD - AN INSTRUMENT FOR THE VALORISATION OF WINE TOURISM POTENTIAL CASE STUDY: ALBA COUNTY VINEYARDS

    Directory of Open Access Journals (Sweden)

    UNGUREANU Mihaela

    2015-12-01

    Full Text Available The main aim of this study is to highlight the wine-growing and wine-making potential of Alba County and the way it can be valorised. Alba county has a rich winegrowing and wine-making heritage, a fact which is due to the long-standing tradition of winegrowing on these area, as well as to the characteristics of the natural factors (relief, geology, climate, soil, favourable for obtaining high-quality wines, the reputation of which has been acquired at national and international competitions. In order to render useful the wine tourism resources, the development of a specific infrastructure is needed, as well as the creation of complex tourist products, able to satisfy a wide range of tourist motivations. An efficient instrument to make productive the wine potential of a region is the „Wine Road" – a tourist trail which includes the tourist attractions of a delimited area, usually with a controlled designation of origin, and also a diverse range of tourist services (transportation, accommodation, catering leisure etc.. In Alba County, the „Wine Road" can be considered as a tourist attraction in itself, but also a means of harnessing the rich cultural-historical and natural heritage and, implicitly, the wine-growing and wine-making heritage.

  10. Mechanisms of P-Glycoprotein Modulation by Semen Strychni Combined with Radix Paeoniae Alba

    Directory of Open Access Journals (Sweden)

    Li-Li Liu

    2017-01-01

    Full Text Available Semen Strychni has been extensively used as a Chinese herb, but its therapeutic window is narrowed by the strong toxicity of the compound, which limits its effectiveness. Radix Paeoniae Alba has been reported to reduce the toxic effects and increase the therapeutic effects of Semen Strychni, but the underlying mechanism remains unknown. This research aimed to explore the mechanism through which P-glycoprotein (P-gp is modulated by Semen Strychni combined with Radix Paeoniae Alba in vitro. An MTT assay was used to study cytotoxicity in an MDCK-MDR1 cell model. Rh123 efflux and accumulation were measured to assess P-gp function. The expression levels of MDR1 mRNA and P-gp protein in MDCK-MDR1 cells were investigated. A P-gp ATPase activity assay kit was applied to detect the effect on P-gp ATPase activity. Semen Strychni combined with Radix Paeoniae Alba could induce P-gp-mediated drug transport by inhibiting brucine and strychnine transport in MDCK-MDR1 cells, enhancing the P-gp efflux function, upregulating the P-gp expression and MDR1 mRNA levels, and stimulating P-gp ATPase activity.

  11. In vitro antimicrobial activity of plant extracts of Avicennia alba against some important pathogens

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    Varahalarao Vadlapudi

    2012-05-01

    Full Text Available Objective: In this present study antimicrobial activity of aerial parts of Avicennia alba were evaluated against the resistant pathogens belong to aquatic, human and plant origin. Methods: Soxhlet extraction method was used to get the corresponding extracts of hexane, chloroform and methanol. The antimicrobial activities of the organic solvent extracts on the various test microorganisms, including bacteria and fungi investigated using agar well diffusion technique. The length of inhibition zone was measured in millimeters from the edge of the well to the edge of the inhibition zone. Methanol and chloroform extracts exhibited promising antimicrobial activity than hexane extracts. Results: The zone of inhibition of chloroform varies from (9 to 17 mm where as with methanol (11 to 28 mm at 100 mg/ml concentration. Among all microorganisms studied Erwinia caratovara and Pseudomonas syringae showed the considerable growth inhibition with chloroform and methanolic extracts. Conclusions: A. alba can be used in the treatment of infectious diseases caused by resistant pathogenic microorganisms. Further studies are being carried out in order to separate the individual components that are present in plant extracts of A. alba using column chromatography.

  12. Characterization of a New Flavone and Tyrosinase Inhibition Constituents from the Twigs of Morus alba L.

    Science.gov (United States)

    Zhang, Long; Tao, Guanjun; Chen, Jie; Zheng, Zong-Ping

    2016-09-02

    The twigs of Morus alba L. were found to show strong tyrosinase inhibition activity, and the responsible active components in the extract were further investigated in this study. A flavone, named morusone (1), and sixteen known compounds 2-17 were isolated from M. alba twigs and their structures were identified by interpretation of the corresponding ESI-MS and NMR spectral data. In the tyrosinase inhibitory test, the compounds steppogenin (IC50 0.98 ± 0.01 µM), 2,4,2',4'-tetrahydroxychalcone (IC50 0.07 ± 0.02 µM), morachalcone A (IC50 0.08 ± 0.02 µM), oxyresveratrol (IC50 0.10 ± 0.01 µM), and moracin M (8.00 ± 0.22 µM) exhibited significant tyrosinase inhibition activities, much stronger than that of the positive control kojic acid. These results suggest that M. alba twig extract should served as a good source of natural tyrosinase inhibitors for use in foods as antibrowning agents or in cosmetics as skin-whitening agents.

  13. Odisolane, a Novel Oxolane Derivative, and Antiangiogenic Constituents from the Fruits of Mulberry (Morus alba L.).

    Science.gov (United States)

    Lee, Seoung Rak; Park, Jun Yeon; Yu, Jae Sik; Lee, Sung Ok; Ryu, Ja-Young; Choi, Sang-Zin; Kang, Ki Sung; Yamabe, Noriko; Kim, Ki Hyun

    2016-05-18

    Mulberry, the fruit of Morus alba L., is known as an edible fruit and commonly used in Chinese medicines as a warming agent and as a sedative, tonic, laxative, odontalgic, expectorant, anthelmintic, and emetic. Systemic investigation of the chemical constituents of M. alba fruits led to the identification of a novel oxolane derivative, (R*)-2-((2S*,3R*)-tetrahydro-2-hydroxy-2-methylfuran-3-yl)propanoic acid (1), namely, odisolane, along with five known heterocyclic compounds (2-6). The structure of the new compound was elucidated on the basis of HR-MS, 1D and 2D NMR ((1)H-(1)H COSY, HSQC, HMBC, and NOESY) data analysis. Compound 1 has a novel skeleton that consists of 8 carbon units with an oxolane ring, which until now has never been identified in natural products. The isolated compounds were subjected to several activity tests to verify their biological function. Among them, compounds 1, 3, and 5 significantly inhibited cord formation in HUVECs. The action mechanism of compound 3, which had the strongest antiangiogenic activity, was mediated by decreasing VEGF, p-Akt, and p-ERK protein expression. These results suggest that compounds isolated from M. alba fruits might be beneficial in antiangiogenesis therapy for cancer treatment.

  14. Characterization of a New Flavone and Tyrosinase Inhibition Constituents from the Twigs of Morus alba L.

    Directory of Open Access Journals (Sweden)

    Long Zhang

    2016-09-01

    Full Text Available The twigs of Morus alba L. were found to show strong tyrosinase inhibition activity, and the responsible active components in the extract were further investigated in this study. A flavone, named morusone (1, and sixteen known compounds 2–17 were isolated from M. alba twigs and their structures were identified by interpretation of the corresponding ESI-MS and NMR spectral data. In the tyrosinase inhibitory test, the compounds steppogenin (IC50 0.98 ± 0.01 µM, 2,4,2′,4′-tetrahydroxychalcone (IC50 0.07 ± 0.02 µM, morachalcone A (IC50 0.08 ± 0.02 µM, oxyresveratrol (IC50 0.10 ± 0.01 µM, and moracin M (8.00 ± 0.22 µM exhibited significant tyrosinase inhibition activities, much stronger than that of the positive control kojic acid. These results suggest that M. alba twig extract should served as a good source of natural tyrosinase inhibitors for use in foods as antibrowning agents or in cosmetics as skin-whitening agents.

  15. Pancreatic lipase inhibitory constituents from Morus alba leaves and optimization for extraction conditions.

    Science.gov (United States)

    Jeong, Ji Yeon; Jo, Yang Hee; Kim, Seon Beom; Liu, Qing; Lee, Jin Woo; Mo, Eun Jin; Lee, Ki Yong; Hwang, Bang Yeon; Lee, Mi Kyeong

    2015-06-01

    The leaves of Morus alba (Moraceae) have been traditionally used for the treatment of metabolic diseases including diabetes and hyperlipidemia. Thus, inhibitory effect of M. alba leaves on pancreatic lipase and their active constituents were investigated in this study. Twenty phenolic compounds including ten flavonoids, eight benzofurans, one stilbene and one chalcones were isolated from the leaves of M. alba. Among the isolated compounds, morachalcone A (20) exerted strong pancreatic lipase inhibition with IC50 value of 6.2 μM. Other phenolic compounds containing a prenyl group showed moderate pancreatic lipase inhibition with IC50 value of <50 μM. Next, extraction conditions with maximum pancreatic lipase inhibition and phenolic content were optimized using response surface methodology with three-level-three-factor Box-Behnken design. Our results suggested the optimized extraction condition for maximum pancreatic lipase inhibition and phenolic content as ethanol concentration of 74.9%; temperature 57.4 °C and sample/solvent ratio, 1/10. The pancreatic lipase inhibition and total phenolic content under optimized condition were found to be 58.5% and 26.2 μg GAE (gallic acid equivalent)/mg extract, respectively, which were well matched with the predicted value. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Oxyresveratrol, a Stilbene Compound from Morus alba L. Twig Extract Active Against Trichophyton rubrum.

    Science.gov (United States)

    Lu, Hai-Peng; Jia, Ya-Nan; Peng, Ya-Lin; Yu, Yan; Sun, Si-Long; Yue, Meng-Ting; Pan, Min-Hui; Zeng, Ling-Shu; Xu, Li

    2017-12-01

    Morus alba L. (mulberry) twig is known to have an inhibitory effect on pathogens in traditional Chinese medicine. In the present study, the dermophytic fungus, Trichophyton rubrum, was used to evaluate the inhibitory effect of total M. alba twig extract and extracts obtained using solvents with different polarities by the method of 96-well MTT colorimetry. The main active substance was isolated and identified by tracking its activity. In addition, the inhibitory effects of active extracts and a single active substance were investigated in combination with miconazole nitrate. Our data indicated that ethyl acetate extracts of mulberry twig (TEE) exhibited a desired inhibitory activity on T. rubrum with the minimum inhibitory concentration (MIC) of 1.000 mg/mL. With activity tracking, the main substance showing antimicrobial activity was oxyresveratrol (OXY), which was isolated from TEE. Its MIC for inhibiting the growth of T. rubrum was 0.500 mg/mL. The combined use of miconazole nitrate and OXY showed a synergistic inhibitory effect, as shown by a significant decrease in the MIC of both components. Based on the OXY content in TEE, the contribution rate of OXY to the inhibitory effect of TEE on T. rubrum was 80.52%, so it was determined to be the main antimicrobial substance in M. alba twig. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  17. Anti-Alzheimer's disease activity of compounds from the root bark of Morus alba L.

    Science.gov (United States)

    Kuk, Eun Bi; Jo, A Ra; Oh, Seo In; Sohn, Hee Sook; Seong, Su Hui; Roy, Anupom; Choi, Jae Sue; Jung, Hyun Ah

    2017-03-01

    The inhibition of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein cleaving enzyme 1 (BACE1) plays important roles in prevention and treatment of Alzheimer's disease (AD). Among the individual parts of Morus alba L. including root bark, branches, leaves, and fruits, the root bark showed the most potent enzyme inhibitory activities. Therefore, the aim of this study was to evaluate the anti-AD activity of the M. alba root bark and its isolate compounds, including mulberrofuran G (1), albanol B (2), and kuwanon G (3) via inhibition of AChE, BChE, and BACE1. Compounds 1 and 2 showed strong AChE- and BChE-inhibitory activities; 1-3 showed significant BACE1 inhibitory activity. Based on the kinetic study with AChE and BChE, 2 and 3 showed noncompetitive-type inhibition; 1 showed mixed-type inhibition. Moreover, 1-3 showed mixed-type inhibition against BACE1. The molecular docking simulations of 1-3 demonstrated negative binding energies, indicating a high affinity to AChE and BACE1. The hydroxyl group of 1-3 formed hydrogen bond with the amino acid residues located at AChE and BACE1. Consequently, these results indicate that the root bark of M. alba and its active compounds might be promising candidates for preventive and therapeutic agents for AD.

  18. Nectar resorption in flowers of Sinapis alba L., Brassicaceae and Platanthera chlorantha Custer (Rchb.), Orchidaceae

    International Nuclear Information System (INIS)

    Masierowska, M.L.; Stpiczynska, M.

    2005-01-01

    Full text: In the flowers of Sinapis alba nectar is secreted by two pairs of nectaries and accumulated as drops between filaments and in the cavity of sepals whereas in Platanthera chlorantha nectar is produced and accumulated within a spur. Previous studies of these species revealed that after a period of secretion and cessation, rapid nectar resorption occurs. The aim of this study was the observation of nectar resorption by the nectaries using radiolabelled sucrose. During the peak of secretion the nectar accumulated in unpollinated flowers was replaced with the same volume of labelled sucrose and after 12-48 hrs of incubation, at the resorption phase, parts of S. alba flowers with nectaries as well as fragments of P. chlorantha spur were sampled and fixed for microautoradiographic studies. In S. alba the presence of [ 14 C(U)] sucrose was detected at the base of nectaries, in phloem elements of main vascular strands supplying glands, whereas both epidermis and nectary parenchyma showed no traces of radiolabelled sugars. In P. chlorantha the presence of labelled sucrose was stated mainly in the walls of nectary cells, which indicate an apoplastic route of reabsorbed nectar. (author)

  19. Improved Chemotherapeutic Activity by Morus alba Fruits through Immune Response of Toll-Like Receptor 4

    Directory of Open Access Journals (Sweden)

    Bo Yoon Chang

    2015-10-01

    Full Text Available Morus alba L. fruits have long been used in traditional medicine by many cultures. Their medicinal attributes include cardiovascular, hepatoprotective, neuroprotective and immunomodulatory actions. However, their mechanism of macrophage activation and anti-cancer effects remain unclear. The present study investigated the molecular mechanisms of immune stimulation and improved chemotherapeutic effect of M. alba L. fruit extract (MFE. MFE stimulated the production of cytokines, nitric oxide (NO and tumor necrosis factor-α (TNF-α and tumoricidal properties of macrophages. MFE activated macrophages through the mitogen-activated protein kinase (MAPKinase and nuclear factor-κB (NF-κB signaling pathways downstream from toll-like receptor (TLR 4. MFE was shown to exhibit cytotoxicity of CT26 cells via the activated macrophages, even though MFE did not directly affect CT26 cells. In a xenograft mouse model, MFE significantly enhanced anti-cancer activity combined with 5-fluorouracil and markedly promoted splenocyte proliferation, natural killer (NK cell activity, cytotoxic T lymphocyte (CTL activity and IFN-γ production. Immunoglobulin G (IgG antibody levels were significantly increased. These results indicate the indirect anti-cancer activity of MFE through improved immune response mediated by TLR4 signaling. M. alba L. fruit extract might be a potential anti-tumor immunomodulatory candidate chemotherapy agent.

  20. Improved Chemotherapeutic Activity by Morus alba Fruits through Immune Response of Toll-Like Receptor 4.

    Science.gov (United States)

    Chang, Bo Yoon; Kim, Seon Beom; Lee, Mi Kyeong; Park, Hyun; Kim, Sung Yeon

    2015-10-13

    Morus alba L. fruits have long been used in traditional medicine by many cultures. Their medicinal attributes include cardiovascular, hepatoprotective, neuroprotective and immunomodulatory actions. However, their mechanism of macrophage activation and anti-cancer effects remain unclear. The present study investigated the molecular mechanisms of immune stimulation and improved chemotherapeutic effect of M. alba L. fruit extract (MFE). MFE stimulated the production of cytokines, nitric oxide (NO) and tumor necrosis factor-α (TNF-α) and tumoricidal properties of macrophages. MFE activated macrophages through the mitogen-activated protein kinase (MAPKinase) and nuclear factor-κB (NF-κB) signaling pathways downstream from toll-like receptor (TLR) 4. MFE was shown to exhibit cytotoxicity of CT26 cells via the activated macrophages, even though MFE did not directly affect CT26 cells. In a xenograft mouse model, MFE significantly enhanced anti-cancer activity combined with 5-fluorouracil and markedly promoted splenocyte proliferation, natural killer (NK) cell activity, cytotoxic T lymphocyte (CTL) activity and IFN-γ production. Immunoglobulin G (IgG) antibody levels were significantly increased. These results indicate the indirect anti-cancer activity of MFE through improved immune response mediated by TLR4 signaling. M. alba L. fruit extract might be a potential anti-tumor immunomodulatory candidate chemotherapy agent.

  1. Composition, anti-quorum sensing and antimicrobial activity of essential oils from Lippia alba

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    Jesus Olivero-Verbel

    2014-09-01

    Full Text Available Many Gram-negative pathogens have the ability to produce N-acylhomoserine lactones (AHLs as signal molecules for quorum sensing (QS. This cell-cell communication system allows them to coordinate gene expression and regulate virulence. Strategies to inhibit QS are promising for the control of infectious diseases or antibiotic resistant bacterial pathogens. The aim of the present study was to evaluate the anti-quorum sensing (anti-QS and antibacterial potential of five essential oils isolated from Lippia alba on the Tn-5 mutant of Chromobacterium violaceum CV026, and on the growth of the gram-positive bacteria S. aureus ATCC 25923. The anti-QS activity was detected through the inhibition of the QS-controlled violacein pigment production by the sensor bacteria. Results showed that two essential oils from L. alba, one containing the greatest geranial:neral and the other the highest limonene:carvone concentrations, were the most effective QS inhibitors. Both oils also had small effects on cell growth. Moreover, the geranial/neral chemotype oil also produced the maximum zone of growth inhibition against S. aureus ATCC 25923. These data suggest essential oils from L. alba have promising properties as QS modulators, and present antibacterial activity on S. aureus.

  2. Extending student knowledge and interest through super-curricular activities

    Science.gov (United States)

    Zetie, K. P.

    2018-03-01

    Any teacher of physics is likely to consider super-curricular reading as an important strategy for successful students. However, there are many more ways to extend a student’s interest in a subject than reading books, and undirected reading (such as providing a long out of date reading list) is not likely to be as helpful as targeted or directed study. I present an approach to directing and supporting additional study pioneered at St Paul’s School in the last 2 years based on two significant steps: • Providing a large, searchable database of reading and other material such as podcasts rather than simply a reading list. • Encouraging students to visualise and plot their trajectory toward a specific goal using a graph

  3. METHODOLOGY FOR CROSS-CURRICULAR THEME OF THE ENVIRONMENTAL AXIS

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    José Luis Aparicio López

    2015-04-01

    Full Text Available This article introduces a methodology to identify the presence of the environmental axis in educational programs in Bachelors in the Universidad Autónoma de Guerrero, Mexico. It is sustained on competency-based education and constructionism, due to they appeal to humanism to deal current problems. It is composed of four phases: committee conformation, theoretical and conceptual concerning analysis, construction and application of instruments on a PE, and identification of the cross-curricular theme level. Even though the proposed methodology is applied to the environment, it is feasible to adapt to other axes, such as human rights, multiculturalism, and poverty, relevant to the educational context of the state of Guerrero.

  4. Evaluation of didactic suitability indicators from curricular orientations

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    Pedro Arteaga

    2012-12-01

    Full Text Available Assessment of didactic suitability of mathematics teaching and learning processes requires suitable instruments to guide and support it. This paper presents a methodology for progressive improvement of such instruments to evaluate the suitability of mathematical instruction processes based on the analysis of curricular orientations. Analysis units are classifi ed according to the facets and components proposed by the Didactic Suitability Theory to identify norms and suitability indicators,which are compared with the system proposed by this theory, in order to point out agreements and complementarities. This methodology is exemplified through its application to the principles and standards of the National Council of Teachers of Mathematics (NCTM in the statistics content area at the level K-8.

  5. A New Approach to Authoring Interactive Curricular Material

    Science.gov (United States)

    Christian, Wolfgang

    2001-10-01

    It is still not common to find computer-based interactive material incorporated into mainstream teaching. Learning the intricacies of a software package is a poor investment of time if the half-life of the textbook is longer than the half-life of the computer technology. Internet technologies are likely to change this situation. This talk describes a set of Java applets, known as Physlets, which make use of these technologies. Physlets are designed to communicate with browsers by employing a scripting language such as JavaScript, thereby allowing one applet to be used in many different contexts. This approach makes it possible to use a modular object-oriented approach for the design of material. But this is not enough. Effective curriculum development must couple our software design philosophy with research into the effectiveness of computer-based instruction. Examples of Physlet-based curricular material will be presented.

  6. Using online program development to foster curricular change and innovation.

    Science.gov (United States)

    Gwozdek, Anne E; Springfield, Emily C; Peet, Melissa R; Kerschbaum, Wendy E

    2011-03-01

    Distance education offers an opportunity to catalyze sweeping curricular change. Faculty members of the University of Michigan Dental Hygiene Program spent eighteen months researching best practices, planning outcomes and courses, and implementing an e-learning (online) dental hygiene degree completion program. The result is a collaborative and portfolio-integrated program that focuses on the development of reflective practitioners and leaders in the profession. A team-based, systems-oriented model for production, implementation, and evaluation has been critical to the program's success. The models and best practices on which this program was founded are described. Also provided is a framework of strategies for development, including the utilization of backward course design, which can be used in many areas of professional education.

  7. Professionalism--a required CLS/CLT curricular component.

    Science.gov (United States)

    Latshaw, Sandra; Honeycutt, Karen

    2010-01-01

    Determine the impact of requiring Clinical Laboratory Science (CLS) students to participate in approved professionalism activities as part of a mandatory management course. Quasi-experimental, case study reporting qualitative results of 25 CLS students. During the admission interview, students complete a written response to questions about their perceptions related to professionalism. During the clinical educational year, students are required to complete approved professionalism activities as part of a management course. At the end of the course, students write a reflective paper focusing on their professional activities and how these experiences will influence their future professional practice. Overall themes of student reflections are provided. University of Nebraska Medical Center (UNMC) CLS Program in Omaha. After participating in a mandatory professionalism curricular component requiring active student participation in professional activities, student reflective writings provide evidence this is one successful approach to nurture professional identity within future Clinical Laboratory Science/Clinical Laboratory Technician (CLS/CLT) practitioners.

  8. El compromiso ambiental universitario: un desafio curricular para trascender

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    Yamile Pedraza-Jiménez

    2017-12-01

    Full Text Available El presente artículo desarrolla una revisión documental sobre la relación y discusión del concepto interdisciplinariedad y su aplicación en el campo ambiental. Pretende informar y complementar el conocimiento existente sobre el supuesto teórico de la interdiciplinariedad que demanda la inclusión de la dimensión ambiental en el contexto universitario indicando sus controversias, límites y posibles vías para abordarla como propuesta curricular. Finalmente, se realiza una discusión sobre el trascender de la interdisciplinariedad al diálogo de saberes como una propuesta política desde el contexto de América Latina, para contribuir a proyectar los fines misionales y el compromiso ambiental universitario.

  9. Skills of Chemistry Pupils during the Period of Curricular Reform

    OpenAIRE

    Bayerová, Anna

    2015-01-01

    Univerzita Karlova v Praze, Přírodovědecká fakulta Katedra učitelství a didaktiky chemie Charles University in Prague, Faculty of Science Department of Teaching and Didactics of Chemistry Doktorský studijní program: Vzdělávání v chemii Ph.D. study program: Education in Chemistry Autoreferát disertační práce Summary of the Ph.D. Thesis Mgr. Anna Bayerová Dovednosti žáků v chemii v období kurikulární reformy Skills of Chemistry Pupils during the Period of Curricular Reform Školitel/Supervisor: ...

  10. Cross-curricular goals and raising the relevance of science education

    DEFF Research Database (Denmark)

    Belova, Nadja; Dittmar, Johanna; Hansson, Lena

    2016-01-01

    education go beyond single contents and concepts; many challenges are tied to cross-curricular goals. Specifically, when it comes to the societal and vocational relevance of science education, many demands can only be met when we develop corresponding skills across disciplines and grade levels. This chapter...... focuses on a set of such cross-curricular goals from a chemistry education perspective, namely education for sustainability, critical media literacy, innovation competence, vocational orientation, and employability. It relates them to the idea of relevant chemistry and science education. Directions...... for research and curriculum development will be suggested that emerge from taking into account cross-curricular goals on the science curriculum more thoroughly....

  11. Los retos de la reespecificación curricular en autonomía universitaria: Aportes de la metateoría curricular neosistémica Os retos da reespecificação curricular em autonomia universitária: Aportes da meta-teoria curricular neosistémica Curricular respecification challenges in university’s autonomy: Contributions of the neo-systemic curricular metatheory

    Directory of Open Access Journals (Sweden)

    Elías Tapiero Vásquez

    2012-03-01

    Full Text Available Se describe, desde lo general hasta lo específico, la metateoría curricular neosistémica. También se plantean las probabilidades de redescripción en autonomía universitaria, desde la reespecificación configurada en el currículo escolar neosistémico.Se descreve, desde o geral até o específico, da meta-teoria curricular neosistémica. Também se propõem as probabilidades de redescrição em autonomia universitária, desde a reespecificação configurada no currículo escolar neosistémico.Both general and specific ideas of the curricular neo-systemic metatheory are described. Also the redescription probabilities in university’s autonomy from the configured respecification in the school’s neo-systemic curriculum are explained.

  12. Quimiotipos, Extracción, Composición y Aplicaciones del Aceite Esencial de Lippia alba

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    G.A. LINDE

    2016-03-01

    Full Text Available RESUMO Lippia alba é uma planta amplamente distribuída nas zonas tropicais, subtropicais e temperadas das Américas, África e Ásia. O óleo essencial de L. alba tem sido amplamente estudado, entretanto apresenta variações de produção. Portanto este estudo teve como objetivo realizar uma revisão dos principais quimiotipos, métodos de extração, composição e aplicação do óleo essencial de L. alba. Neste estudo são discutidos os principais quimiotipos e sua relação com fatores genéticos e características morfológicas. Também são discutidos os fatores que afetam o rendimento de produção, composição química, métodos de extração e do uso e da atividade biológica do óleo essencial de L. alba. Apesar da vasta literatura sobre os óleos essenciais de L. alba, ainda desenvolvimento de aplicações para a produção de cosméticos, fármacos e alimentos, bem como faltam definições agronomicas sobre o cultivo e melhoramento desta planta.

  13. Ameliorative effect of Morus alba leaves extract against developmental retinopathy in pups of diabetic and aluminum intoxicated pregnant albino rats

    Institute of Scientific and Technical Information of China (English)

    Hassan; El-Sayyed; Gamal; Badawy; Sobhy; Hassab; Elnabi; Ibrahim; El-Elaimy; Eman; Al; Shehari

    2015-01-01

    Objective: To investigate the possible ameliorative effect of crude water extract of Morus alba(M. alba) leaves on retinopathy of rat pups maternally subjected to diabetes and/or Al intoxication.Methods: Both control and experimental groups were subjected to certain integrated approaches, namely, biochemical assessments, light microscopic investigation, transmission electron microscopic investigation, single cell gel electrophoresis(comet assay) and determination of DNA fragmentation.Results: The retina of pups of diabetic and/or Al-intoxicated mothers exhibited abnormal alterations in retinal cell layers including retinal pigmented epithelium, photoreceptor inner segment and ganglion cells. Increased incidence of DNA fragmentation and apoptosis were evident in pups of diabetic and/or Al-intoxicated mothers. However, retina of pups maternally received M. alba extract plus diabetes or Al-intoxicated alone or in combination showed marked amelioration. Less degree of ameliorations was seen in retina of pups maternally subjected to combined treatment. Furthermore, application of crude water extract of M.alba resulted in amelioration of the alterations of maternal serum glucose as well as Al concentration.Conclusions: Based on the results of the present study, M. alba extract is effective against experimentally diabetic and Al-induced developmental retinopathy.

  14. The Effectiveness of Super Ovulation and Multiple Pregnancies in Sprague Dawley Rat using Morus alba Linn. Fruit

    Directory of Open Access Journals (Sweden)

    Heshu Sulaiman Rahman

    2018-01-01

    Full Text Available The white mulberry, Morus alba L. has been used by several Asian societies for the treatment of infertility. However, there is no evidence that products of the plant can influence ovarian health. Thus, the aim of this study was to determine the effect of the Morus alba fruit extract on the ovarian function of nonpregnant and pregnant rats. The study showed that in rats Morus alba fruit extract stimulates follicular stimulating (FSH and luteinizing hormones (LH, estrogen, and progesterone productions that peaked at 8 days of treatment. The effect was dose-dependent with hormone production increasing with increase in dose of the extract. The Graafian follicles were fully matured, and the number increased with increase in dose of the extract. The uterus of pregnant rats contained several embryos that gave birth to the full-term offspring without abortion or embryonic abnormalities. In conclusion, the Morus alba fruit extract can be used to induce superovulation to cause multiple pregnancies. Thus, the Morus alba fruit extract has potential to be developed into a compound for the treatment of female infertility.

  15. Characterization of Melanogenesis Inhibitory Constituents of Morus alba Leaves and Optimization of Extraction Conditions Using Response Surface Methodology.

    Science.gov (United States)

    Jeong, Ji Yeon; Liu, Qing; Kim, Seon Beom; Jo, Yang Hee; Mo, Eun Jin; Yang, Hyo Hee; Song, Dae Hye; Hwang, Bang Yeon; Lee, Mi Kyeong

    2015-05-14

    Melanin is a natural pigment that plays an important role in the protection of skin, however, hyperpigmentation cause by excessive levels of melatonin is associated with several problems. Therefore, melanogenesis inhibitory natural products have been developed by the cosmetic industry as skin medications. The leaves of Morus alba (Moraceae) have been reported to inhibit melanogenesis, therefore, characterization of the melanogenesis inhibitory constituents of M. alba leaves was attempted in this study. Twenty compounds including eight benzofurans, 10 flavonoids, one stilbenoid and one chalcone were isolated from M. alba leaves and these phenolic constituents were shown to significantly inhibit tyrosinase activity and melanin content in B6F10 melanoma cells. To maximize the melanogenesis inhibitory activity and active phenolic contents, optimized M. alba leave extraction conditions were predicted using response surface methodology as a methanol concentration of 85.2%; an extraction temperature of 53.2 °C and an extraction time of 2 h. The tyrosinase inhibition and total phenolic content under optimal conditions were found to be 74.8% inhibition and 24.8 μg GAE/mg extract, which were well-matched with the predicted values of 75.0% inhibition and 23.8 μg GAE/mg extract. These results shall provide useful information about melanogenesis inhibitory constituents and optimized extracts from M. alba leaves as cosmetic therapeutics to reduce skin hyperpigmentation.

  16. Characterization of Melanogenesis Inhibitory Constituents of Morus alba Leaves and Optimization of Extraction Conditions Using Response Surface Methodology

    Directory of Open Access Journals (Sweden)

    Ji Yeon Jeong

    2015-05-01

    Full Text Available Melanin is a natural pigment that plays an important role in the protection of skin, however, hyperpigmentation cause by excessive levels of melatonin is associated with several problems. Therefore, melanogenesis inhibitory natural products have been developed by the cosmetic industry as skin medications. The leaves of Morus alba (Moraceae have been reported to inhibit melanogenesis, therefore, characterization of the melanogenesis inhibitory constituents of M. alba leaves was attempted in this study. Twenty compounds including eight benzofurans, 10 flavonoids, one stilbenoid and one chalcone were isolated from M. alba leaves and these phenolic constituents were shown to significantly inhibit tyrosinase activity and melanin content in B6F10 melanoma cells. To maximize the melanogenesis inhibitory activity and active phenolic contents, optimized M. alba leave extraction conditions were predicted using response surface methodology as a methanol concentration of 85.2%; an extraction temperature of 53.2 °C and an extraction time of 2 h. The tyrosinase inhibition and total phenolic content under optimal conditions were found to be 74.8% inhibition and 24.8 μg GAE/mg extract, which were well-matched with the predicted values of 75.0% inhibition and 23.8 μg GAE/mg extract. These results shall provide useful information about melanogenesis inhibitory constituents and optimized extracts from M. alba leaves as cosmetic therapeutics to reduce skin hyperpigmentation.

  17. A meta-analysis of efficacy of Morus alba Linn. to improve blood glucose and lipid profile.

    Science.gov (United States)

    Phimarn, Wiraphol; Wichaiyo, Kittisak; Silpsavikul, Khuntawan; Sungthong, Bunleu; Saramunee, Kritsanee

    2017-06-01

    The previous studies have reported the Morus alba may improve blood glucose and lipid profile. The evidence from these studies is not consistent. This meta-analysis was to evaluate efficacy of products derived from M. alba on blood glucose and lipid levels. Literature was reviewed via international database (PubMed, PubMed Central, ScienceDirect, and SciSearch) and Thai databases. Thirteen RCTs with high quality, assessed by Jadad score, were included. M. alba expressed a significant reduction in postprandial glucose (PPG) at 30 min (MD -1.04, 95 % CI -1.36, -0.73), 60 min (MD -0.87, 95 % CI -1.27, -0.48) and 90 min (MD -0.55, 95 % CI -0.87, -0.22). The difference was not found in the levels of other glycaemic (FBS, HbA1C, or HOMA-IR) and lipidaemic (TC, TG, LDL, or HDL) markers. Serious adverse effects were found neither in the control nor in the group received M. alba. Products derived from M. alba can effectively contribute to the reduction in PPG levels, but large-scale RCTs would be informative.

  18. Consideraciones Sobre la Línea de Investigación en Inteligencia Organizacional en el Doctorado en Ingeniería de la U.D.F.J.C.On Research Aspects of Organizational Intelligence at the Engineering Doctoral Program of U.D.F.J.C.

    Directory of Open Access Journals (Sweden)

    Germán Andres Méndez Giraldo

    2014-10-01

    Full Text Available Este documento presenta los aspectos más relevantes de la línea de investigación de Inteligencia Organizacional en el contexto del Doctorado en Ingeniera de la Universidad Distrital, cuyo principal énfasis es el de en Ciencia y Tecnología de la Información y del Conocimiento. Desde esta óptica, la Inteligencia Organizacional permite estudiar y entender las formas en que las organizaciones generan, socializan y utilizan el conocimiento individual y colectivo para su beneficio. Esta línea propende por contextualizar estos procesos en el caso colombiano, a su vez se pretende estudiar a las organizaciones sociales desde los enfoques basados en los modelos de inteligencia. Todo esto se encamina a difundir estas temáticas a fin de permitir que en el Doctorado se cree un mayor entendimiento y por ello, potencializar las investigaciones en el ámbito de las empresas y de la sociedad en general apoyadas por el grupo de investigación de Sistemas Expertos y Simulación.

  19. Doutorado-sanduíche em enfermagem: relato de experiência Doctorado sándwich en enfermería: relato de experiencia Sandwich doctoral program in nursing: an experience report

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    Rosane Arruda Dantas

    2009-06-01

    Full Text Available Relato de experiência acerca de estágio de doutorando-sanduíche realizado com bolsa da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, durante o período de outubro de 2005 a janeiro de 2006, na Faculdade de Enfermagem de D. Ana Guedes, no Porto, em Portugal, instituição já visitada na graduação. Tive a oportunidade de replicar a metodologia de parte da dissertação com crianças portuguesas. Isso permitiu estudo comparativo entre duas culturas que guardam afinidades, mas têm características distintas. Além disso, ministrei aulas, participei de cursos e seminários e aprofundei os conhecimentos acerca da Teoria da Universalidade e Diversidade do Cuidado Cultural. Considero que esta experiência é um estímulo para a garantia da autonomia do enfermeiro na assistência de enfermagem, como pesquisador e docente, ampliando conhecimentos e os inserindo no processo de cuidado. Ademais, influencia positivamente no amadurecimento psicológico, cultural e social do doutorando.Relato de experiencia acerca de pasantía de doctorado sándwich realizado con suporte financiero de la Coordinación de Mejora del Personal del Nivel Superior, durante el período de octubre de 2005 a enero de 2006, en la Facultad de Enfermería de D. Ana Guedes, en Porto, Portugal, institución ya visitada durante la graduación. Tuve la oportunidad de replicar la metodología de parte de la disertación junto a niños portugueses. Esto permitió un estudio comparativo entre dos culturas que guardan afinidades, pero tienen características distintas. Además, ministré clases, participé de cursos y seminarios y me profundicé en los conocimientos acerca de la Teoría de la Universalidad y Diversidad del Cuidado Cultural. Considero que esta experiencia es un estímulo para la garantía de la autonomía del enfermero en la atención de enfermería, como investigadora y docente, ampliando conocimientos e insertándolos en el proceso de cuidado. Adem

  20. Curricular renovation in the phonoaudiology program of the University of Cauca: a proposal for educational quality

    Directory of Open Access Journals (Sweden)

    Liliana María Pérez-Tenorio

    2010-09-01

    Full Text Available In Colombia, the Superior Education is going through a transformation process. These changes must be in coherence with the formulation of flexible policies among the diverse components of the curriculum and with the need for new forms of working and producing knowledge. The curricular renovation must ref lect an educational quality compromise and contribute to generate human development with high social impact. This article presents a proposal for Curricular Renovation, elaborated by faculty and students of the Phonoaudiology Program of the University of Cauca. This document contains aspects related to the pedagogic model, didactics, faculty-student relation, systems of evaluation and plan of studies. Furthermore, in this document the bases for the Route of Curricular Renovation are presented, consisting of the following phases: background, diagnosis and operational plan. These should facilitate the academic integration for adjusting the curricular processes to the needs of the academic program in a local, national and international context.

  1. Reducing School Violence: School-Based Curricular Programs and School Climate

    Science.gov (United States)

    Greene, Michael B.

    2008-01-01

    This article examines two different, but interrelated approaches to reduce school violence: school-based curricular programs and efforts to change school climate. The state of the research for each is reviewed and the relationship between them is explored.

  2. Adaptación curricular de “Programación en Internet”

    OpenAIRE

    Luján Mora, Sergio

    2016-01-01

    Trabajo del curso “Adaptaciones Curriculares para la Inclusión de Estudiantes con Necesidades Educativas Especiales” impartido en la Escuela Politécnica Nacional (Quito, Ecuador) del 16 al 22 de marzo de 2016.

  3. Tuning-América Latina y su compatibilidad con el modelo curricular cubano

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    Rebeca Vega Miche

    2009-01-01

    El objetivo de este trabajo consiste en analizar cómo las competencias genéricas acordadas por el proyecto Tuning son compatibles con el modelo curricular cubano que persigue la formación integral del profesional. Se valora a partir de la experiencia de la licenciatura de química el desarrollo de las habilidades y capacidades de Tuning a partir de las diferentes actividades curriculares.

  4. Sistema reprodutivo do Ipê-Branco: Tabebuia roseo-alba (Ridley Sandwith (Bignoniaceae Breeding system of the White Trumpet Tree: Tabebuia roseo-alba (Ridley Sandwith (Bignoniaceae

    Directory of Open Access Journals (Sweden)

    Gabriel Gandolphi

    2010-09-01

    Full Text Available Estudos sobre sistemas reprodutivos têm indicado o predomínio da autoincompatibilidade de ação tardia (AIT em Bignoniaceae, embora poucas espécies tenham sido investigadas e ocorram outros tipos de sistemas reprodutivos na família. O presente estudo objetivou determinar o sistema reprodutivo de T. roseo-alba através de experimentos de polinizações controladas, análise histológica dos eventos posteriores à polinização, verificação do desenvolvimento in situ dos tubos polínicos e testes de germinação de sementes. Apesar de os tubos polínicos penetrarem e fecundarem a maioria dos óvulos em pistilos autopolinizados, o aborto de 100% dos mesmos foi verificado e, embora sua abscisão tenha ocorrido entre o quarto e o sexto dia após o início da antese, observou-se um ligeiro crescimento dos óvulos e do ovário precedendo a abscisão, porém inferior ao crescimento nos pistilos submetidos à polinização cruzada. A endospermogênese inicial e a formação do tubo proembriônico também foram mais lentas nos pistilos autopolinizados. A longevidade dos pistilos autopolinizados foi maior que a de pistilos não polinizados, e a taxa de germinação de sementes foi de 93%, sendo todas as sementes monoembriônicas. Os resultados demonstram que T. roseo-alba é espécie auto-estéril, destituída de poliembrionia e que apresenta AIT pós-zigótica.Breeding system studies have indicated the predominance of late-acting self-incompatibility (LSI in Bignoniaceae, despite the relatively few species investigated, and the occurrence of other kinds of breeding systems in this family. This study aimed to determine the breeding system in T. roseo-alba by means of controlled experimental pollination, histological analysis of post-pollination events, and studies of pistil longevity, in situ pollen tube growth and seed germination. Despite pollen tube penetration and fertilization of most ovules of selfed pistils, 100% of these pistils aborted

  5. Karyotype analysis, DNA content and molecular screening in Lippia alba (Verbenaceae

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    Patrícia M.O. Pierre

    2011-09-01

    Full Text Available Cytogenetic analyses, of pollen viability, nuclear DNA content and RAPD markers were employed to study three chemotypes of Lippia alba (Mill. (Verbenaceae in order to understand the genetic variation among them. Different ploidy levels and mixoploid individuals were observed. This work comprises the first report of different chromosome numbers (cytotypes in L. alba. The chromosome numbers of La2-carvone and La3-linalool chemotypes suggested that they are polyploids. Flow cytometric analysis showed an increase of nuclear DNA content that was not directly proportional to ploidy level variation. A cluster analysis based on RAPD markers revealed that La3-linalool shares genetic markers with La1-citral and La2-carvone. The analysis showed that the majority of genetic variation of La3-linalool could be a consequence of ixoploidy. ur data indicates that sexual reproduction aong those three chemotypes is unlikely and suggests the beginning of reproductive isolation. The results demonstrated that chromosome analysis, nuclear DNA content estimation and RAPD markers constitute excellent tools for detecting genetic variation among L. alba chemotypes.Análises citogenéticas, de viabilidade do pólen, do conteúdo de DNA nuclear e marcadores RAPD foram empregadas no estudo de três quimiotipos de Lippia alba (Mill. (Verbenaceae visando contribuir para o entendimento da variação genética entre os mesmos. Diferentes níveis de ploidia e indivíduos mixoploides foram observados. Este trabalho compreende o primeiro relato de diferentes números cromossômicos (citótipos em L. alba. Os números cromossômicos dos quimiotipos La2-carvona e La3-linalol sugere que eles seja poliploides. A análise da citometria de fluxo mostrou um aumento do conteúdo de DNA nuclear que não foi diretamente proporcional à variação no nível de ploidia. A análise de agrupamento baseada nos marcadores RAPD demonstrou que La3-linalol compartilha marcadores genéticos com La1

  6. Uncorrected land-use planning highlighted by flooding: the Alba case study (Piedmont, Italy)

    Science.gov (United States)

    Luino, F.; Turconi, L.; Petrea, C.; Nigrelli, G.

    2012-07-01

    Alba is a town of over 30 000 inhabitants located along the Tanaro River (Piedmont, northwestern Italy) and is famous for its wine and white truffles. Many important industries and companies are based in Alba, including the famous confectionery group Ferrero. The town suffered considerably from a flood that occurred on 5-6 November 1994. Forty-eight percent of the urban area was inundated, causing severe damage and killing nine people. After the flood, the Alba area was analysed in detail to determine the reasons for its vulnerability. Information on serious floods in this area since 1800 was gathered from official records, state technical office reports, unpublished documents in the municipal archives, and articles published in local and national newspapers. Maps, plans and aerial photographs (since 1954) were examined to reconstruct Alba's urban development over the last two centuries and the planform changes of the Tanaro River. The results were compared with the effects of the November 1994 flood, which was mapped from aerial photographs taken immediately after the flood, field surveys and eyewitness reports. The territory of Alba was subdivided into six categories: residential; public service; industrial, commercial and hotels; sports areas, utilities and standards (public gardens, parks, athletics grounds, private and public sport clubs); aggregate plants and dumps; and agriculture and riverine strip. The six categories were then grouped into three classes with different flooding-vulnerability levels according to various parameters. Using GIS, the three river corridors along the Tanaro identified by the Autorità di Bacino del Fiume Po were overlaid on the three classes to produce a final map of the risk areas. This study shows that the historic floods and their dynamics have not been duly considered in the land-use planning of Alba. The zones that were most heavily damaged in the 1994 flood were those that were frequently affected in the past and sites of

  7. Uncorrected land-use planning highlighted by flooding: the Alba case study (Piedmont, Italy

    Directory of Open Access Journals (Sweden)

    F. Luino

    2012-07-01

    Full Text Available Alba is a town of over 30 000 inhabitants located along the Tanaro River (Piedmont, northwestern Italy and is famous for its wine and white truffles. Many important industries and companies are based in Alba, including the famous confectionery group Ferrero.

    The town suffered considerably from a flood that occurred on 5–6 November 1994. Forty-eight percent of the urban area was inundated, causing severe damage and killing nine people. After the flood, the Alba area was analysed in detail to determine the reasons for its vulnerability.

    Information on serious floods in this area since 1800 was gathered from official records, state technical office reports, unpublished documents in the municipal archives, and articles published in local and national newspapers. Maps, plans and aerial photographs (since 1954 were examined to reconstruct Alba's urban development over the last two centuries and the planform changes of the Tanaro River.

    The results were compared with the effects of the November 1994 flood, which was mapped from aerial photographs taken immediately after the flood, field surveys and eyewitness reports.

    The territory of Alba was subdivided into six categories: residential; public service; industrial, commercial and hotels; sports areas, utilities and standards (public gardens, parks, athletics grounds, private and public sport clubs; aggregate plants and dumps; and agriculture and riverine strip. The six categories were then grouped into three classes with different flooding-vulnerability levels according to various parameters. Using GIS, the three river corridors along the Tanaro identified by the Autorità di Bacino del Fiume Po were overlaid on the three classes to produce a final map of the risk areas.

    This study shows that the historic floods and their dynamics have not been duly considered in the land-use planning of Alba. The zones that were most heavily damaged in the 1994 flood were

  8. Protective effects of the Morus alba L. leaf extracts on cisplatin-induced nephrotoxicity in rat

    Science.gov (United States)

    Nematbakhsh, M; Hajhashemi, V; Ghannadi, A; Talebi, A; Nikahd, M

    2013-01-01

    Cisplatin (CP) as an important anti-tumor drug causes nephrotoxicity mainly by oxidative stress and renin-angiotensin system (RAS). Since flavonoids have high antioxidant activity and probable role in the inhibition of RAS, this study was designed to investigate the protective effect of hydroalcoholic extract and flavonoid fraction of Morus alba leaves on cisplatin-induced nephrotoxicity in rat. Extracts of Morus alba leaves were prepared and analyzed Phytochemically. Male rats (160-200 g) were used in this study (n=7-9). Normal group received 0.2 ml normal saline intraperitoneally (i.p.) once daily for ten days. Control animals received CP on the third day and saline in the remaining days. Other groups received either hydroalcoholic extract (200, 400 and 600 mg/kg, i.p.) or flavonoid fraction (50, 100 and 200 mg/kg, i.p.) for two days before CP administration and thereafter until tenth day. Serum concentrations of blood urea nitrogen (BUN), creatinine (Cr) and nitric oxide were measured using standard methods. Also left kidneys were prepared for pathological study. The serum levels of BUN and Cr increased in animals received CP. Hydroalcoholic extract was ineffective in reversing these alterations but flavonoid fraction (50 and 100 mg/kg) significantly inhibited CP-induced increases of BUN and Cr. None of the treatments could affect serum concentration of nitric oxide. Flavonoid fraction could also prevent CP-induced pathological damage of the kidney. It seems that concurrent use of flavonoid fraction of Morus alba with CP can protect kidneys from CP-induced nephrotoxicity. PMID:24019816

  9. Salix alba attenuated oxidative stress in the heart and kidney of hypercholesterolemic rabbits

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    Narges Amel Zabihi

    2017-12-01

    Full Text Available Objective: Oxidative stress plays a critical role in the development of hypercholesterolemia-induced complications. This study evaluated the effects of aspirin and Salix alba hydroethanolic extract on oxidative stress in the heart and kidney of hypercholesterolemic rabbits. Materials and Methods: The antioxidant activity, as well as total phenolic and salicin content of S. alba (Sa extract were assessed by DPPH radical scavenging activity, Folin-Ciocalteu and HPLC methods, respectively. Animals were divided into two groups of control (fed with normal chow, and HD (fed with high cholesterol diet for 6 weeks. Then, hypercholesterolemic animals allocated to the following treatment groups: CHO (received HD, Sa extract (HD plus extract 60 and 120 mg/kg, and aspirin (HD plus aspirin 120 mg/kg and received the treatments on a daily basis for 6 weeks. MDA, GSH, and nitrite concentrations as well as the activities of SOD and CAT were evaluated in cardiac and kidney tissues. Results: The scavenging activity, total phenolic content and salicin were 19.1 µg/ml (IC50, 153.75 ± 3.6 mg of gallic acid/g, and 18.03 µg/mg, respectively. In comparison to CHO group, MDA levels were diminished in Sa and ASA groups but GSH levels were improved. NO metabolites increased in the heart of Sa 120 mg/kg group and in the kidney of all Sa and ASA treated groups. SOD activity increased only in the heart of Sa groups and in the kidney of Sa and ASA groups. CAT activity increased in the heart and kidney tissues of all Sa and ASA treated groups. Conclusion: The results showed S. alba extract improved redox homeostasis in heart and kidney tissues of hypercholesterolemic rabbits. The extract antioxidant property may be related to its phenolic content.

  10. CURRICULAR DESIGN FOR THE CONSTRUCTION OF A PEACE CULTURE

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    Raiza González

    2009-04-01

    Full Text Available This investigation had as purpose from the analysis of the contributions of sciences of the conduct, pedagogical and spiritual, to apply a curricular design for the development of competitions  in the educational one like mediator of a culture of peace in the classroom. study was descriptive, of action-reflection-intervention in the modality of study of case with application of tests you diagnose, observation log, shootings, psicoterapéuticas interviews, techniques and factories, considering the analysis units: documents and   students. The population was represented by the students of the Elective I: mention Sciences and Technology of the Education. The results revealed that educational as mediating of a peace culture must demonstrate competitions of knowing, doing, to coexist and to be; in the field of the Neurolingüística; conflict mediation; familiar constellations; psiconeuroimunología; support psycotherapy; intelligence  interpersonal, emotional and naturista; abilities for the negotiation and cooperation; responsibility, respect, discipline, honesty, gratitude, coherence, empathy, spiritual development,  faith and nonviolence.

  11. Multiple Intelligences within the Cross-Curricular Approach

    Directory of Open Access Journals (Sweden)

    Anthoula Vaiou

    2010-02-01

    Full Text Available The present study was realized in a Greek 6th grade State Primary School class and was based on Howard Gardner’s theory of multiple intelligences, which was first introduced in 1983. More particularly, it was explored to what extent the young learners possess multiple intelligences through the use of a specially-designed questionnaire and a series of interviews. The findings of the above have served as a tool to the construction of a project work based on students’ learning preferences within a cross-curricular framework, easily applicable to the Greek State School curriculum. All learners were activated to participate within a school environment that traditionally promotes linguistic and mathematical skills matching dominant multiple intelligences or a combination of some of them to thematic units already taught by Greek teachers. The suggested project was assessed through observation and student portfolio, showing that the young learners’ multiple intelligences were exploited to a great extent, promoting the learning process satisfactorily. The results of this study can provide a contribution to the literature of multiple intelligences in the Greek reality and suggest a need for further consideration and exploration in the field. Finally, the researcher of this study hopes the present work could function as a springboard for more elaborated studies in the future.

  12. Proyecto curricular institucional: Una alternativa para el cambio

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    Ruth Vallejo

    2002-01-01

    Full Text Available Enfrentar el desafío de la construcción del proyecto curricular institucional representa para la educación de este milenio una prioridad, esto sin lugar a dudas, requiere de un cambio en la estructura organizativa y de gestión en cada plantel; el Currículo Básico Nacional, en marcha, representa un avance significativo, para superar esta situación. Para que esta reforma constituya una alternativa válida, es necesario abordar la formación del docente de forma sistemática, continúa desde su praxis por medio de la investigación-acción, utilizando herramientas metodológicas para el diagnóstico y acompañando todo el proceso con una evaluación institucional que al mismo tiempo que se analiza e implementa permita la formación de los actores involucrados; la revisión y los ajustes permanentes conducen a la construcción de aproximaciones sucesivas que con el trabajo concertado garantizan la viabilidad del proyecto. Se recomienda asumirlo con un carácter cíclico y dinámico para decidir si se puede o no mantener a la luz de los cambios que ocurran dentro y fuera del proceso.

  13. CONSTRUINDO UM MODELO CURRICULAR INTEGRADO PARA A EJA/FIC

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    Raimundo Nonato O. Furtado

    2013-11-01

    Full Text Available Esse trabalho apresenta um modelo possível de desenvolvimento estrutural curricular integral, composto a partir da experiência dos autores, com o Projeto Mulheres Mil – Educação, Cidadania e Desenvolvimento Sustentável, Sub-Projeto “Desenvolvimento Comunitário: Impacto na Qualidade de Vida e Ambiental”, firmado pela parceria SETEC/MEC e o Group Collegia, do Quebec, Canadá. O Projeto Mulheres Mil foi inicialmente desenhado para execução da Rede Norte-Nordeste dos ex-CEFETs, hoje Institutos Federais, com execução a partir de 2008, no Instituto Federal da Paraíba, Campus João Pessoa. Teve o objetivo de apoiar, na prática, um dos modelos de políticas de inclusão social, revestido, na forma inicial, pelo Reconhecimento da Aprendizagem Prévia, tendo como alvo pessoas fora da faixa etária da escolaridade regular, trabalhadoras e, sem exceção, mulheres.

  14. RESEARCH CONCERNING MORPHO CHARACTERISTICS OF ROMANIAN BLACK SPOTTED BREEDED IN CONDITION OF S.C. BIOTERA FARM, ALBA COUNTY

    Directory of Open Access Journals (Sweden)

    Alin AVRAM

    2013-01-01

    Full Text Available Researches regarding morpho characteristics of Romanian Black Spotted breed were performed on 56 cows bull daughters in testing and candidate as bull's mother, raised and exploited in SC Biotera SRL farm from Alba county and has as database, records of evaluation for reliability cows between 2004 -2009 from UARZ – Alba county. Analyzing the results we can see that for Romanian Black Spotted breed, size increases from the average of 142.92 cm in first lactation to 145.64 in the third lactation. Similar happens with the height at rump wich from 143.54 cm in first lactation reach to 146.86 in the third lactation.

  15. Oil production at different stages of leaf development in Lippia alba

    OpenAIRE

    Diego Pandeló; Talita D. Melo; Júnya L. Singulani; Fernanda A. F. Guedes; Marco A. Machado; Cíntia M. Coelho; Lyderson F. Viccini; Marcelo O. Santos

    2012-01-01

    The aim of this work was to analyze terpene oil production and terpene synthases (TPS) gene expression from leaves at different developmental stages of different chemotypes of Lippia alba (Mill.) N.E. Br. ex Britton & P. Wilson, Verbenaceae. Hydro-distilled essential oil were used for chemical analysis and gene expression of three monoterpene synthase genes called LaTPS12, LaTPS23 and LaTPS25 were used for analyses of gene expression associated to oil production. The putative genes were a...

  16. Abscisic acid-type sesquiterpenes and ansamycins from Amycolatopsis alba DSM 44262.

    Science.gov (United States)

    Li, Xiao-Mei; Li, Xiao-Man; Lu, Chun-Hua

    2017-10-01

    Two new abscisic acid-type sesquiterpenes (1, 2), and one new ansamycin (3), together with four known ansamycins, namely ansacarbamitocins 4-7, were isolated from the fermentation extract of Amycolatopsis alba DSM 44262. The structures of the new compounds were elucidated to be (E)-3-methyl-5-(2,6,6-trimethyl-3-oxocyclohex-1-enyl)pent-2-enoic acid (1) and (E)-3-methyl-5-(2,6,6-trimethyl-4-oxocyclohex-2-enyl)pent-2-enoic acid (2), and 9-O-methylansacarbamitocin A1 (3), on the basis of comprehensive analysis of spectroscopic data, respectively. The antimicrobial activities were also evaluated for all seven compounds.

  17. Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba.

    Science.gov (United States)

    Huang, Qing-Hua; Lei, Chun; Wang, Pei-Pei; Li, Jing-Ya; Li, Jia; Hou, Ai-Jun

    2017-10-01

    Two new Diels-Alder adducts, albasins A and B (1 and 2), one new isoprenylated 2-arylbenzofuran, albasin C (3), one new isoprenylated flavone, albasin D (4), together with sixteen known phenolic compounds, were isolated from the root bark of Morus alba. Their structures were elucidated by extensive spectroscopic analysis, including NMR, MS, and ECD data. All the new compounds and most of the known ones showed significant inhibitory effects on PTP1B in vitro with IC 50 values ranging from 0.57 to 7.49μM. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Complete genome sequence of Defluviimonas alba cai42T, a microbial exopolysaccharides producer.

    Science.gov (United States)

    Zhao, Jie-Yu; Geng, Shuang; Xu, Lian; Hu, Bing; Sun, Ji-Quan; Nie, Yong; Tang, Yue-Qin; Wu, Xiao-Lei

    2016-12-10

    Defluviimonas alba cai42 T , isolated from the oil-production water in Xinjiang Oilfield in China, has a strong ability to produce exopolysaccharides (EPS). We hereby present its complete genome sequence information which consists of a circular chromosome and three plasmids. The strain characteristically contains various genes encoding for enzymes involved in EPS biosynthesis, modification, and export. According to the genomic and physiochemical data, it is predicted that the strain has the potential to be utilized in industrial production of microbial EPS. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. 116 Etude du régime alimentaire de la Chouette effraie Tyto alba ...

    African Journals Online (AJOL)

    SWEET

    Résumé. Nous présentons dans ce travail les résultats de l'analyse du régime alimentaire d'un rapace nocturne. (la Chouette effraie Tyto alba) dans les plaines du Maroc atlantique à partir de plusieurs lots de pelotes de réjection collectées en 2012. Il s'agit de deux régions de la plaine du Gharb, une située dans un milieu.

  20. Comparison of the pathogenicity, growth, sporulation and morphology of Pezicula alba Guthrie (Gloeosporium album Osterw.

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    H. Borecka

    2013-12-01

    Full Text Available Sixteen isolates of Pezicula alba Guthr. were examined. The intensity of growth on various media, pathogenicity to apple fruits and twigs, colour of cultures and size of conidia were measured. Some isolates are pathogenic to fruits, some others to twigs; one isolate (only no. 19 is pathogenic to both twigs and fruits; many isolates are not - pathogenic at all. Culture growth, sporulation and size of conidia are not correlated with the pathogenicity of the isolate. The mean size of conidia is 21.29µm x 3.48µm.

  1. Alexandre Grandazzi, Alba Longa. Histoire d’une légende

    OpenAIRE

    Richard, Jean-Claude

    2012-01-01

    Il libro di A. Grandazzi si segnala per le dimensioni e per la portata della ricerca : circa mille pagine, distribuite su due volumi di pari ampiezza, sviluppano, per la prima volta in modo esaustivo, il vessato problema storiografico relativo alla genesi della leggenda romana di Alba Longa. L’autore mostra con chiarezza che le prime scoperte archeologiche sui Colli Albani, risalenti al 1816-1817, riportarono in auge un’antica questione, sentita già in epoca romana : l’esatta localizzazione d...

  2. Morphology and histochemistry of glandular trichomes of Orobanche alba Stephan ex Willd

    Directory of Open Access Journals (Sweden)

    Aneta Sulborska

    2014-04-01

    Full Text Available Orobanche alba Stephan ex Willd is an achlorophyllous root parasite rare in Poland. It prefers dry and sunny slopes, xerothermic grasslands and pastures, mountain pastures, light scrubs, and rock fissures and ledges. The hosts of O. alba include Thymus polytrichus A. ern. ex Borbás, Clinopodium vulgare L. and Origanum vulgare L. The tick and fleshy 10-70 cm high stem in this species bears an inflorescence composed of zygomorphic, white or yellow “spotted” flowers covered by purple glandular trichomes. Glandular trichomes of this type are also borne on other parts of the plant, i.e. on the stem, scaly leaves, sepals, filaments, and the style. The secondary metabolites secreted by the glandular trichomes are related to defense of plants against the attack of herbivores and pathogens or act as attractants to pollinators or for fruit dispersal. The micromorphology and histochemistry of the glandular trichomes in O. alba were examined using scanning electron and light microscopes. In order to determine the type of secondary metabolites produced by the trichomes, the flowing histochemical assays were used: Sudan III and neutral red for detection of lipophilic compounds, IKI for detection of starch, and FeCl3 for detection of phenolic compounds. The peltate glandular trichomes of O. alba were characterised by a varied length (0.15‑0.48 mm and different activity phases. The trichome was composed of one larger basal epidermal cell, 1-3 hyaline stalk cells with a striated cuticle, a neck cell with a smooth cuticle on the surface, and a globose head formed of 8-18 secretory cells arranged in a circle. Many stalk cells of the trichomes, particularly those located on the corolla, contained anthocyanins, which give the trichomes dark carmine colour. In turn, the colour of the heads was dependent on trichome age: the heads were brown in older trichomes and yellow in younger hairs. Secretion was produced by both young and older trichomes. It penetrated

  3. Two new isoarylbenzofuran diglucosides from the root bark of Morus alba.

    Science.gov (United States)

    Park, Ji-Hae; Jung, Ye-Jin; Jung, Jae-Woo; Shrestha, Sabina; Han, Daeseok; Lim, Dong Wook; Baek, Nam-In

    2015-01-01

    Two new arylbenzofuran diglucopyranosides, (2″R)-(-)-moracin-O-5',3″-β-D-diglucopyranoside (1) and (2″R)-(-)-moracin-P-5',2″-β-d-diglucopyranoside (2), along with known arylbenzofurans, moracin M 6-β-D-glucopyranoside (3), and an isomeric mixture of R-(-)-moracin O (4) and R-(-)-moracin P (5), were isolated from the root bark of Morus alba L. The structure of the compounds was elucidated based on mass spectrometry, infrared, 1D and 2D nuclear magnetic resonance spectroscopic data.

  4. Evaluation of anti-inflammatory activity of prenylated substances isolated from Morus alba and Morus nigra.

    Science.gov (United States)

    Zelová, Hana; Hanáková, Zuzana; Čermáková, Zuzana; Šmejkal, Karel; Dalĺ Acqua, Stefano; Babula, Petr; Cvačka, Josef; Hošek, Jan

    2014-06-27

    Chromatographic separation of root extracts of Morus alba and M. nigra led to the identification of the 2-arylbenzofurans moracin C (1), mulberrofuran Y (2), and mulberrofuran H (3), and the prenylated flavonoids kuwanon E (4), kuwanon C (5), sanggenon H (6), cudraflavone B (7), and morusinol (8), and the Diels-Alder adducts soroceal (9), and sanggenon E (10). The cytotoxicity and their antiphlogistic activity, determined as the attenuation of the secretion of TNF-α and IL-1β and the inhibition of NF-κB nuclear translocation in LPS-stimulated macrophages, were evaluated for compounds 1-10.

  5. Six New Record Species of Whiteflies (Hemiptera: Aleyrodidae) Infesting Morus alba in China

    Science.gov (United States)

    Wang, Ji-Rui; Song, Zao-Qin; Du, Yu-Zhou

    2014-01-01

    Abstract To determine the species of whiteflies occurring on mulberry, Morus alba L. (Rosales: Moraceae) in China, we collected samples in more than 87 sites in 16 provinces of China from 2008 to 2011. In total, 10 species, representing seven genera of the subfamily Aleyrodinae, were identified. Of these, six species are newly recorded on mulberry in China, namely, Aleuroclava ficicola Takahashi, Aleuroclava gordoniae (Takahashi), Aleurotrachelus camelliae (Kuwana), Bemisia afer (Priesner & Hosny), Bemisia tabaci Gennadius, and Pealius machili Takahashi. Information on the taxonomy, distribution, and host plants of the whitefly species found on mulberry in China, along with a brief description and illustrations of each species are provided. PMID:25368095

  6. Human colon cancer HT-29 cell death responses to doxorubicin and Morus Alba leaves flavonoid extract.

    Science.gov (United States)

    Fallah, S; Karimi, A; Panahi, G; Gerayesh Nejad, S; Fadaei, R; Seifi, M

    2016-03-31

    The mechanistic basis for the biological properties of Morus alba flavonoid extract (MFE) and chemotherapy drug of doxorubicin on human colon cancer HT-29 cell line death are unknown. The effect of doxorubicin and flavonoid extract on colon cancer HT-29 cell line death and identification of APC gene expression and PARP concentration of HT-29 cell line were investigated. The results showed that flavonoid extract and doxorubicin induce a dose dependent cell death in HT-29 cell line. MFE and doxorubicin exert a cytotoxic effect on human colon cancer HT-29 cell line by probably promoting or induction of apoptosis.

  7. De novo transcriptome analysis of Sinapis alba in revealing the glucosinolate and phytochelatin pathways

    Directory of Open Access Journals (Sweden)

    Xiaohui eZhang

    2016-03-01

    Full Text Available Sinapis alba is an important condiment crop and can also be used as a phytoremediation plant. Though it has important economic and agronomic values, sequence data and the genetic tools are still rare in this plant. In the present study, a de novo transcriptome based on the transcriptions of leaves, stems and roots was assembled for S. alba for the first time. The transcriptome contains 47,972 unigenes with a mean length of 1,185 nt and an N50 of 1,672 nt. Among these unigenes, 46,535 (97% unigenes were annotated by at least one of the following databases: NCBI non-redundant (Nr, Swiss-Prot, Kyoto Encyclopedia of Genes and Genomes (KEGG pathway, Gene Ontology (GO, and Clusters of Orthologous Groups of proteins (COGs. The tissue expression pattern profiles revealed that 3,489, 1,361 and 8,482 unigenes were predominantly expressed in the leaves, stems and roots of S. alba, respectively. Genes predominantly expressed in the leaf were enriched in photosynthesis- and carbon fixation-related pathways. Genes predominantly expressed in the stem were enriched in not only pathways related to sugar, ether lipid and amino acid metabolisms but also plant hormone signal transduction and circadian rhythm pathways, while the root-dominant genes were enriched in pathways related to lignin and cellulose syntheses, involved in plant-pathogen interactions, and potentially responsible for heavy metal chelating and detoxification. Based on this transcriptome, 14,727 simple sequence repeats (SSRs were identified, and 12,830 pairs of primers were developed for 2,522 SSR-containing unigenes. Additionally, the glucosinolate (GSL and phytochelatin metabolic pathways, which give the characteristic flavor and the heavy metal tolerance of this plant, were intensively analyzed. The genes of aliphatic GSLs pathway were predominantly expressed in roots. The absence of aliphatic GSLs in leaf tissues was due to the shutdown of BCAT4, MAM1 and CYP79F1 expressions. Glutathione was

  8. On the phase characterization of the residues of the plant Comandante Pedro Soto Alba

    International Nuclear Information System (INIS)

    Diaz Ruano, A.; Fernandez Miranda, J.

    1980-04-01

    It has been studied of the phases present in the solid industrial residues of the plant Comandante Pedro Soto Alba (Moas's tails). It is done a preliminary qualitative characterization by X ray diffraction. It is done a characterization by differential and gravimetric thermal analysis and a quantitative valuation of SO 3 and H 2 O present in the samples. A complex of S and Al is detected. The results of SO 3 are compared with those obtained by the gravimetric method to verify those of Al, an elemental analysis by neutron activation was solicitated. A formula for the complex of S and Al is proposed. (author)

  9. A formação prática de professores no estágio curricular Practical curricular training of teachers

    Directory of Open Access Journals (Sweden)

    Helena Maria dos Santos Felício

    2008-01-01

    Full Text Available Partindo da premissa de que a dimensão prática deve ser considerada na formação inicial de professores, entendemos que o Estágio Curricular, se bem fundamentado, estruturado e orientado, configura-se como um momento relevante na perspectiva curricular do processo de formação prática dos futuros professores. Dessa forma, o presente artigo apresenta algumas reflexões e discussões, oriundas de uma investigação qualitativa, sobre a importância e o papel do Estágio Curricular na formação prática de alunos. Os sujeitos desta pesquisa são alunos concluintes do Curso Normal Superior da Universidade do Vale do Paraíba (UNIVAP. A partir da interpretação de diferentes autores(LIMA, 2001; TARDIF, 2002; PIMENTA, 2001; GÓMEZ, 2000, compreendemos a prática enquanto práxis, uma vez que, permeada por um processo de reflexão, ela pode ser construída e reconstruída, objetivando a transformação da realidade escolar. Sendo assim, evidenciamos, nos relatórios apresentados e nos discursos dos alunos, as aprendizagens práticas consideradas construídas durante o estágio. Analisamos os dados recolhidos, à luz da teoria estudada sobre a formação prática e profissional dos professores. Identificamos os aspectos favoráveis e desfavoráveis da realização do estágio curricular na dimensão de ser um espaço/tempo, também destinado à construção de conhecimentos práticos na formação dos professores. E, finalmente, propomos novas perspectivas para a orientação e realização do estágio curricular na formação de professores, centradas na relevância da formação prática e na articulação entre todas as disciplinas do curso de formação.Based on the premise that the practical dimension must be considered in the initial training of teachers, we understand that curricular training, if well founded, structured and oriented, is relevant to the curricular outlook of the practical training process for future teachers. This article

  10. Oil production at different stages of leaf development in Lippia alba

    Directory of Open Access Journals (Sweden)

    Diego Pandeló

    2012-06-01

    Full Text Available The aim of this work was to analyze terpene oil production and terpene synthases (TPS gene expression from leaves at different developmental stages of different chemotypes of Lippia alba (Mill. N.E. Br. ex Britton & P. Wilson, Verbenaceae. Hydro-distilled essential oil were used for chemical analysis and gene expression of three monoterpene synthase genes called LaTPS12, LaTPS23 and LaTPS25 were used for analyses of gene expression associated to oil production. The putative genes were associated to TPS-b gene class. Semi-quantitative PCR and quantitative PCR (qPCR analysis were used to investigate the expression profile of those three putative genes in different leaf stages and different chemotypes. Additionally, total oil production and gene expression of putative TPS genes cloned from L. alba chemotype linalool were evaluated at different stages of leaf development. The expression level of those three genes was higher when the highest oil production was observed, mainly in young leaves at the fourth nodal segment for all evaluated chemotypes. Total oil production was higher at leaves that had unopened trichomes. We also observed that the 1mM of MeJA treatment increased the gene expression in all chemotypes after 24 h elicitation.

  11. Oil production at different stages of leaf development in Lippia alba

    Directory of Open Access Journals (Sweden)

    Diego Pandeló

    2012-01-01

    Full Text Available The aim of this work was to analyze terpene oil production and terpene synthases (TPS gene expression from leaves at different developmental stages of different chemotypes of Lippia alba (Mill. N.E. Br. ex Britton & P. Wilson, Verbenaceae. Hydro-distilled essential oil were used for chemical analysis and gene expression of three monoterpene synthase genes called LaTPS12, LaTPS23 and LaTPS25 were used for analyses of gene expression associated to oil production. The putative genes were associated to TPS-b gene class. Semi-quantitative PCR and quantitative PCR (qPCR analysis were used to investigate the expression profile of those three putative genes in different leaf stages and different chemotypes. Additionally, total oil production and gene expression of putative TPS genes cloned from L. alba chemotype linalool were evaluated at different stages of leaf development. The expression level of those three genes was higher when the highest oil production was observed, mainly in young leaves at the fourth nodal segment for all evaluated chemotypes. Total oil production was higher at leaves that had unopened trichomes. We also observed that the 1mM of MeJA treatment increased the gene expression in all chemotypes after 24 h elicitation.

  12. [Analysis of variation of monoterpene glycosides and polyhydroxy compounds in paeoniae radix alba during preliminary processing].

    Science.gov (United States)

    Xu, Yuan; Liu, Pei; Yan, Hui; Qian, Da-Wei; Duan, Jin-Ao

    2014-05-01

    To investigate variation of monoterpene glycosides and polyhydroxy compounds in Paeoniae Radix Alba dried by different processing methods. The crude drugs were processed sequentially as washed, removed the head, tail, fine roots and dried. The samples were divided into eight groups by whether peeled and decocted or not. Each group was dried by 35, 45, 60, 80,100, 120 degrees C, sun-dried and shade-dried. HPLC-PDA method was adopted to determine the content of monoterpene glycosides compounds (paeoniflorin alibiflorin, oxypaeoniflorin and benzoylpaeoniflorin), polyhydroxy compounds (catechin and gallic acid) and benzoic acid. Chromatographic conditions: Phecad C18 column (250 mm x 4.6 mm, 5 microm). A principal component analysis (PCA) method was used subsequently to get data processed. The retained content of seven constituents decreased in those peeled crude drug, and after cooked, monoterpene glycosides and polyhydroxy compounds increased while the benzoic acid decreased. It was believed that rele- vant enzymes were inactivated while being cooked so that drying temperature showed little influence on the biotransformation. Contents of effective ingredients in Paeoniae Radix Alba are influenced by drying processing. The preferable method shows to be that crude drug should be cooked before being peeled and dried. As a matter of processing convtence, it is suggested to be peeled and sliced before being dried.

  13. Investigation of heavy metals content in medicinal plant, eclipta alba L

    International Nuclear Information System (INIS)

    Hussain, I.; Khan, H.

    2010-01-01

    Heavy metal such as Cr, Fe, Zn, Mn, Ni, Pb, Cu and Cd were investigated in a= medicinally important plant, Eclipta alba L. as well as in the soil it was grown using atomic absorption spectrophotometer. The plant samples were collected from their natural habitat at three different locations of Peshawar Pakistan. The whole plant materials (roots, stems and leaves) were found to contain all heavy metals except Cd, which corresponds to their concentration in the soil it was grown. Among all the heavy metals, Fe was found to be at the highest level (8.95 to 27.7 mg/kg) followed by Mn (0.44 to 14.0 mg/kg) and Zn (1.04 to 4.50 mg/kg), while the rest of metals were at low concentration. The present study showed that E. alba L. is suitable for the control of environmental pollutants such as heavy metals, however, for medicinal purposes; it should be collected from those areas which are not contaminated with heavy metals. The purpose of the current study was to standardize various indigenous medicinal plants for heavy metals contamination and to make awareness among the public regarding its safer use and collection areas, containing high level of heavy metals and their adverse health affects. (author)

  14. Selection of new clones of linalool chemotype from genetic recombination in Lippia alba

    Directory of Open Access Journals (Sweden)

    Elcio Rodrigo Rufino

    2012-01-01

    Full Text Available The aromatic and medicinal species Lippia alba is vigorous and rugged native to the South America (Atlantic Rainforest. Because it is an allogamous and self-incompatible species, natural populations have high morphological and chemical variability. This work had as objective to conduct a preliminary screening to identify new promising clones from a novel (recombinant base population of Lippia alba with regard to its agronomic and phytochemical traits, using the linalool oil or chemotype as model. The two superior linalool clones, obtained by collection, were used as controls. Traits evaluated included: dry mass of leaves (DML, oil yield percentage (EOY%, oil production per plant (OP, and linalool percentage (LN%. Forty linalool chemotype clones were evaluated in three experiments, in a random block design with four replicates and four cuttings (clones per plot. Besides means comparisons, multivariate analysis was used in order to aid in the preliminary selection of clones. There were positive correlations from moderate to strong for DML vs. EOY%, OP vs. EOY% and DML vs. OP. Linalool clones superior or similar to both controls were identified for the DML, EOY%, OP, and LN% traits (univariate analyses, aimed at further validating experimentation. Five distinct groups were defined in the cluster analysis (UPGMA, each containing subgroups as well.

  15. Anti-Melanogenic Properties of Greek Plants. A Novel Depigmenting Agent from Morus alba Wood.

    Science.gov (United States)

    Chaita, Eliza; Lambrinidis, George; Cheimonidi, Christina; Agalou, Adamantia; Beis, Dimitris; Trougakos, Ioannis; Mikros, Emmanuel; Skaltsounis, Alexios-Leandros; Aligiannis, Nektarios

    2017-03-23

    In therapeutic interventions associated with melanin hyperpigmentation, tyrosinase is regarded as a target enzyme as it catalyzes the rate-limiting steps in mammalian melanogenesis. Since many known agents have been proven to be toxic, there has been increasing impetus to identify alternative tyrosinase inhibitors, especially from natural sources. In this study, we investigated 900 extracts from Greek plants for potential tyrosinase inhibitive properties. Among the five most potent extracts, the methanol extract of Morus alba wood (MAM) demonstrated a significant reduction in intracellular tyrosinase and melanin content in B16F10 melanoma cells. Bioassay-guided isolation led to the acquisition of twelve compounds: oxyresveratrol (1), kuwanon C (2), mulberroside A (3), resorcinol (4), dihydrooxyresveratol (5), trans-dihydromorin (6), 2,4,3'-trihydroxydihydrostilbene (7), kuwanon H (8), 2,4-dihydroxybenzaldehyde (9), morusin (10), moracin M (11) and kuwanon G (12). Among these, 2,4,3'-trihydroxydihydrostilbene (7) is isolated for the first time from Morus alba and constitutes a novel potent tyrosinase inhibitor (IC50 0.8 ± 0.15). We report here for the first time dihydrooxyresveratrol (5) as a potent natural tyrosinase inhibitor (IC50 0.3 ± 0.05). Computational docking analysis indicated the binding modes of six tyrosinase inhibitors with the aminoacids of the active centre of tyrosinase. Finally, we found both MAM extract and compounds 1, 6 and 7 to significantly suppress in vivo melanogenesis during zebrafish embryogenesis.

  16. Nuclear techniques used in study of biological processes in Sinapis alba culture

    International Nuclear Information System (INIS)

    Giosanu, D.; Fleancu, M.

    2001-01-01

    The aim of the present paper is to study different nuclear techniques, in particular the influence of gamma radiation upon germination, growth and respiration processes in Sinapis alba culture. The dependence of these phenomena on dose of gamma irradiation was studied. Research was done on dry seeds of mustard (Sinapis alba).The doses of gamma irradiation were: 20 krad, 40 krad, 60 krad, 80 krad and 100 krad.The subsequent evolution of the irradiated samples was compared with the evolution of an unirradiated (control) samples. The irradiation was done evenly, in a single phase. The treatment of the dry seeds of mustard with gamma radiation determined a diminution of energy of germination. So, the energy of germination was 57 - 73% in gamma treated batches and 81% in the control batch. Thus, the faculty of germination decreases from 92% (in the control batch) to 83% in the irradiated batches. Growth process (length of roots and hypocotyl) was also studied. For 100 krad gamma irradiation the rate of this process was lower than that of the control batch, both in the first and the four day of irradiation. The inhibition effect manifested on germination and growth processes for gamma treated dry seeds of mustard is determined by the modification in the membrane permeability. The intensity of respiration process in the irradiated lots was lower than that of the control lot. The inhibition effect manifested by respiration process following gamma irradiation could be explained by the enzymatic activity of mustard seeds. (authors)

  17. Seeing The "New Forest": A Visual Curricular Experiment

    Science.gov (United States)

    Garramone, Pariss Nicola

    In contemporary Western contexts, human interaction with and interpretation of nature is a perpetually mediated process. Understandings and engagements with natural environments are informed by and often overlaid with meanings derived from representations. In other words, representations help constitute human relationships with nature. Thus learning how representations shape human understandings and experiences of nature and the resulting social, political, and ecological impact of these mediated relationships has emerged as an important field of inquiry within environmental education. This dissertation examines how a critical, self-reflexive act of looking at photographs can challenge an individual's concepts of nature/culture, real/imaginary, and self/other. The project engages in a curricular experiment where the researcher explores how photography meditates her abstract and embodied understandings of specific natural environments. A critical, self-reflexive approach to aesthetic engagement with photographs moves beyond simply deciphering or decoding representations; it incorporates the learner's own narrative and embodied responses to the photographic representations being explored. This approach also recognizes that pedagogy has a transformative effect; both the learner and the representations being explored are transformed through the process of engagement. In this dissertation, a selection of iconic photographs of Canadian tree planting from the collection of the National Gallery of Canada are looked at: Lorraine Gilbert's (1987-2004) series "Shaping the New Forest" and Sarah Anne Johnson's (2005) work "The Tree Planting Project." The aim of this project is twofold: to unravel how these photographs construct and transform knowledge of and relationships with the environment in Canada, and to demonstrate a model of environmental inquiry that can be integrated into critical environmental education curricula.

  18. Morus alba and active compound oxyresveratrol exert anti-inflammatory activity via inhibition of leukocyte migration involving MEK/ERK signaling.

    Science.gov (United States)

    Chen, Yi-Ching; Tien, Yin-Jing; Chen, Chun-Houh; Beltran, Francesca N; Amor, Evangeline C; Wang, Ran-Juh; Wu, Den-Jen; Mettling, Clément; Lin, Yea-Lih; Yang, Wen-Chin

    2013-02-23

    Morus alba has long been used in traditional Chinese medicine to treat inflammatory diseases; however, the scientific basis for such usage and the mechanism of action are not well understood. This study investigated the action of M. alba on leukocyte migration, one key step in inflammation. Gas chromatography-mass spectrometry (GC-MS) and cluster analyses of supercritical CO2 extracts of three Morus species were performed for chemotaxonomy-aided plant authentication. Phytochemistry and CXCR4-mediated chemotaxis assays were used to characterize the chemical and biological properties of M. alba and its active compound, oxyresveratrol. fluorescence-activated cell sorting (FACS) and Western blot analyses were conducted to determine the mode of action of oxyresveratrol. Chemotaxonomy was used to help authenticate M. alba. Chemotaxis-based isolation identified oxyresveratrol as an active component in M. alba. Phytochemical and chemotaxis assays showed that the crude extract, ethyl acetate fraction and oxyresveratrol from M. alba suppressed cell migration of Jurkat T cells in response to SDF-1. Mechanistic study indicated that oxyresveratrol diminished CXCR4-mediated T-cell migration via inhibition of the MEK/ERK signaling cascade. A combination of GC-MS and cluster analysis techniques are applicable for authentication of the Morus species. Anti-inflammatory benefits of M. alba and its active compound, oxyresveratrol, may involve the inhibition of CXCR-4-mediated chemotaxis and MEK/ERK pathway in T and other immune cells.

  19. The potential of mangrove Avicennia marina and A. Alba from Nguling district, Pasuruan, East Java as an antioxidant

    Science.gov (United States)

    Iranawati, F.; Muhammad, F.; Fajri, H.; Kasitowati, R. D.; Arifin, S.

    2018-04-01

    Free radicals are highly reactive molecules due to unpaired electron in their outer orbital. Excess of free radicals inside human body as consequences of environmental exposure such cigarette smoke may lead to degenerative diseases such as diabetic, cancer etc. This negative effect can be limited by the utilization of natural antioxidant substances, especially produced from plant. Avicennia alba dan A. marina are mangrove species that widely distributed in Indonesia and are expected potential as antioxidant. The objective of this study is to evaluated Avicennia alba dan A. marina potency as antioxidant performed with DPPD (1,1-diphenyl-β-picryl hydrazyl) method. Leaf and bark of Avicennia alba dan A. marina were collected from Nguling District, Pasuruan, East Java. Results shows that based on 50% inhibition Concentration (IC50), Avicennia alba leaf were categorized had a very high antioxidant potential (IC50 14,85 ppm) whereas the bark were categorized had a weak antioxidant potential IC50 167,17 ppm). For A. marina, the leaf were categorized had a moderate antioxidant (IC50 123,23 ppm) whereas the bark were categorized had a weak antioxidant potential (IC50 198,15 ppm).

  20. Optimization of sample preparation variables for wedelolactone from Eclipta alba using Box-Behnken experimental design followed by HPLC identification.

    Science.gov (United States)

    Patil, A A; Sachin, B S; Shinde, D B; Wakte, P S

    2013-07-01

    Coumestan wedelolactone is an important phytocomponent from Eclipta alba (L.) Hassk. It possesses diverse pharmacological activities, which have prompted the development of various extraction techniques and strategies for its better utilization. The aim of the present study is to develop and optimize supercritical carbon dioxide assisted sample preparation and HPLC identification of wedelolactone from E. alba (L.) Hassk. The response surface methodology was employed to study the optimization of sample preparation using supercritical carbon dioxide for wedelolactone from E. alba (L.) Hassk. The optimized sample preparation involves the investigation of quantitative effects of sample preparation parameters viz. operating pressure, temperature, modifier concentration and time on yield of wedelolactone using Box-Behnken design. The wedelolactone content was determined using validated HPLC methodology. The experimental data were fitted to second-order polynomial equation using multiple regression analysis and analyzed using the appropriate statistical method. By solving the regression equation and analyzing 3D plots, the optimum extraction conditions were found to be: extraction pressure, 25 MPa; temperature, 56 °C; modifier concentration, 9.44% and extraction time, 60 min. Optimum extraction conditions demonstrated wedelolactone yield of 15.37 ± 0.63 mg/100 g E. alba (L.) Hassk, which was in good agreement with the predicted values. Temperature and modifier concentration showed significant effect on the wedelolactone yield. The supercritical carbon dioxide extraction showed higher selectivity than the conventional Soxhlet assisted extraction method. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  1. Genome Sequence of the Enterobacter mori Type Strain, LMG 25706, a Pathogenic Bacterium of Morus alba L. ▿

    Science.gov (United States)

    Zhu, Bo; Zhang, Guo-Qing; Lou, Miao-Miao; Tian, Wen-Xiao; Li, Bin; Zhou, Xue-Ping; Wang, Guo-Feng; Liu, He; Xie, Guan-Lin; Jin, Gu-Lei

    2011-01-01

    Enterobacter mori is a plant-pathogenic enterobacterium responsible for the bacterial wilt of Morus alba L. Here we present the draft genome sequence of the type strain, LMG 25706. To the best of our knowledge, this is the first genome sequence of a plant-pathogenic bacterium in the genus Enterobacter. PMID:21602328

  2. Photosynthesis and xanthophyll cycle-mediated photoprotection in leaves of Quercus rubra and Q. alba seedlings of different light environments

    Science.gov (United States)

    Shi-Jean S. Sung; Dianpeng Xu; Paul P. Kormanik; Clanton C. Black

    1997-01-01

    Two and three years after the outplanting of 1-0 northern red oak (Quercus rubra, NRO) and white oak (Q. alba, WO) nursery stocks, the highest net photosynthetic rates (Amax) were observed from seedlings growing on a clearcut site, followed by those under a pine stand. Both NRO and WO...

  3. Using Continuing Professional Development to Create Meaningful Co-Curricular Learning Opportunities for all Student Pharmacists.

    Science.gov (United States)

    Vos, Susan S; Sabus, Ashley; Seyfer, Jennifer; Umlah, Laura; Gross-Advani, Colleen; Thompson-Oster, Jackie

    2018-05-01

    Objective. To illustrate a method for integrating co-curricular activities, quantify co-curricular activities, and evaluate student perception of achievement of goals. Methods. Throughout a longitudinal course, students engaged in self-selected, co-curricular activities in three categories: professional service, leadership, and community engagement. Hours were documented online with minimum course requirements. Students reflected on experiences and assessed goal attainment. Assignments were reviewed by faculty and feedback was given to each student. Results. From 2010 to 2016, there were 29,341 co-curricular hours documented by 756 students. The most popular events were attending pharmacy organization meetings and participating in immunization clinics. More than half of the students agreed they were able to meet all of their professional goals (mix of career and course goals) while 70% indicated goals were challenging to meet. Conclusion. This method for integrating co-curricular activities using a continuing professional development model demonstrates a sustainable system for promoting professional development through experience and self-reflection.

  4. Doutorado sanduíche: considerações para uma experiência de sucesso no exterior Doctorado sándwich: consideraciones para una experiencia exitosa en el extranjero 'Sandwich PhD': considerations for a successful experience abroad

    Directory of Open Access Journals (Sweden)

    Marina de Goes Salvetti

    2013-03-01

    Full Text Available O estágio de doutorado no exterior, conhecido, no Brasil, como "Doutorado Sanduíche", é uma oportunidade de aprimorar as habilidades em pesquisa, destacar-se no meio acadêmico e estabelecer e/ou ampliar oportunidades de trabalho em contexto internacional. Neste artigo, descrevemos elementos-chave do processo de planejamento e desenvolvimento do Doutorado Sanduíche aprendidos por professores e alunos envolvidos na colaboração entre a Escola de Enfermagem da Universidade de São Paulo e a Lawrence S. Bloomberg Faculty of Nursing, Universidade de Toronto, Canadá, e apresentamos a participação em uma rede de doutorados, como alternativa ao Doutorado Sanduíche. A experiência internacional, quando bem planejada e desenvolvida, promove o desenvolvimento pessoal e profissional do aluno, favorece a internacionalização dos programas de pós-graduação e dos grupos de pesquisa brasileiros.Una estancia de doctorado internacional, "Doctorado Sándwich" como es conocido en Brasil, es una oportunidad de mejorar las habilidades de investigación, hacerse conocido académicamente y establecer y/o agrandar las oportunidades de trabajo en el contexto internacional. En este artículo, nosotros describimos factores importantes del proceso de la planificación y desarrollo del "Doctorado Sándwich" aprendidos por estudiantes y profesores involucrados en la colaboración entre la Escuela de Enfermería de la Universidad de São Paulo y la Facultad de Enfermería Lawrence S. Bloomberg, Universidad de Toronto, Canadá y presentamos la participación en una red de doctorados como una alternativa a la estancia doctoral internacional. La experiencia internacional, cuando bien planeada y desarrollada, promueve el desarrollo personal y profesional del estudiante y favorece la internacionalización de los programas de postgrado y de los grupos de investigación brasileños.International PhD internship, named "Sandwich PhD'" in Brazil, is an opportunity to

  5. Pastoreo restringido de ovejas Pelibuey en bancos de proteína de morera (Morus alba Restricted grazing of Pelibuey ewes in protein banks of mulberry (Morus alba

    Directory of Open Access Journals (Sweden)

    P.E Lara

    2007-06-01

    Full Text Available Con el objetivo de medir el efecto del pastoreo de ovejas Pelibuey en un banco de proteína de morera (Morus alba en el comportamiento productivo, se desarrolló un experimento completamente al azar y se utilizaron 10 ovejas de tercer parto con 32 + 2,6 kg de PV, considerando una oveja como unidad experimental; los tratamientos fueron: grupo testigo (T pastoreo en pasto estrella más 250 g de alimento concentrado animal-1 d-1 y pastoreo restringido (2 h d-1 en morera (M. Se encontró diferencia (PWith the objective of measuring the effect of grazing by Pelibuey ewes in a protein bank of mulberry (Morus alba on the productive performance, a completely randomized trial was carried out and 10 third parturition ewes with 32 ± 2,6 kg LW were used, considering one ewe as experimental unit; the treatments were: control -1 -1 -1 group (C grazing in star grass plus 250 g of concentrate feed animal d and restricted grazing (2 h d in mulberry (M. Difference (P < 0,05 was found in the body condition at the moment of weaning, of 2,46 ± 0,30 in C and 2,00 ± 0,24 in M. The voluntary intake (VI of the ewes was higher in mulberry, with 5,05% in pregnancy and 2,97% in lactation with regards to group C (4,28 and 2,28%. The weight at birth and weaning, as well as the MDG were better (P < 0,05 in the offspring of group C with 3,77; 15,61 and 0,207 vs 2,82; 13,01 and 0,185 kg, respectively. This was due to a lower prolificacy in C, for which the kilograms born and weaned were higher in M, with 5,86 and 23,41 vs 4,52 and 18,74 for C. The regrowth capacity of mulberry was optimal for grazing after 70 days, for which it is feasible to substitute the supplementation with concentrate in ewes by restricted grazing for 2 h in a mulberry bank during pregnancy and lactation.

  6. INNOVACION CURRICULAR EN TURISMO: UN CAMPO DE ESTUDIO Y REFERENTES PARA LA FORMACIÓN UNIVERSITARIA

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    Lucía M. Collado Medina

    2013-01-01

    Full Text Available El artículo presenta un panorama de la investigación curricular en turismo reportada en México y otros países, principalmente latinoamericanos. Se definen tendencias, impactos, alcances, pautas de problemáticas emergentes, y referentes para aclarar enfoques y modelos de la formación profesional e innovación curricular de este campo. Con base en el método de mapeo se seleccionaron y valoraron las fuentes que sustentan este estudio, mediante las cuales se plantean los retos para la construcción de modelos curriculares innovadores. Se vislumbran nuevos paradigmas inter y transdisciplinarios para abordar curricularmente el caso del turismo. Con respecto a lo anterior, se concluye tomar en cuenta supuestos epistemológicos congruentes con la complejidad y la incertidumbre que subyacen a los modelos de formación en turismo, pertinentes al entorno social y humano.

  7. Curricular Critique of an Environmental Education Policy Framework: Acting Today, Shaping Tomorrow

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    Douglas D. Karrow

    2015-10-01

    Full Text Available The following paper is a curricular critique of an environmental education policy framework called Acting Today, Shaping Tomorrow (2009. It is founded upon: (a an examination of the conventional argument for integrated curriculum models and its relevance to K-12 environmental education; and (b utilization of a typology of integrated curriculum models to analyze an environmental education policy framework within the jurisdiction of Ontario, Canada. In conclusion, Ontario’s environmental education policy framework tends toward an integrated curriculum model referred to as ‘selective infusion.’  The implications for integrated curricular practice are identified, with recommendations for improving the policy framework from an integrated curricular perspective.     Key Words: environmental education, integrated curriculum, curriculum critique, education policy.

  8. Los programas de diversificación curricular desde la transversalidad

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    María Ángeles PASCUAL SEVILLANO

    2009-11-01

    Full Text Available RESUMEN: La enseñanza en la diversidad requiere ante todo de una innovación curricular que apueste por un proceso y contexto educativo que se adapte al individuo. Introducir en la enseñanza los intereses provocados de la propuesta de los ejes transversales no significa desplazar las materias curriculares, sino diseñar los objetivos y contenidos propios de las áreas curriculares para que puedan adquirirse y desarrollarse desde la transversalidad, permitiendo así un mayor acercamiento y contextualización con la realidades cada estudiante y con los conflictos y problemas del mundo contemporáneo y, a la vez dotándolos de un valor funcional inmediato respecto a la comprensión y posible transformación de esa realidad y de esos conflictos. En este sentido los aspectos que tratan de incorporarse no son algo añadido, pero si novedoso desde el momento en que se introduce una nueva perspectiva, y se evita el riesgo, a veces tan mencionado, de que la transversalidad aparezca sutilmente desdibujada. Los ejes transversales bajo este nuevo planteamiento implicarán una importante transformación de las áreas curriculares de acuerdo con las expectativas de los tiempos presentes y la adecuación a las posibilidades de comprensión del alumnado. Esto será así, si los enfoques transversales, que constituyen el centro de las actuales preocupaciones sociales de las áreas curriculares, se convierten en el núcleo en torno a los cuales gira la programación de las áreas curriculares, las cuales se convertirán entonces en los instrumentos necesarios para la consecución de las finalidades deseadas.ABSTRACT: The Education in the diversity requires of a curricular innovation that bet on a process and educational context that is adapted to the individual. To introduce in the teaching the provoked interest of the proposal of the transverse shafts does not mean to displace the curricular matters, and yes to design the objectives and own contents of the

  9. Toxicity Of The Essential Oil Of The Cytral Chemotype Of Lippia Alba (Mill. N. E. Brown Toxicidad del aceite esencial de Lippia alba (Mill. N. E. Brown quimiotipo citral

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    Jesús Olivero-Verbel

    2010-06-01

    Full Text Available The essential oil (EO of Lippia alba (Mill. N. E. Brown (Verbenaceae has been traditionally used to treat several diseases. In this study, the acute toxic effects of the citral chemotype of L. alba EO were evaluated in mice. Animals were treated via intraperitoneal receiving the L. alba essential oil at doses between 50 and 2500 mg/kg, and the control group received sesame oil (vehicle. The EO induced dose-dependent neurotoxic effects at doses greater than 1000 mg/kg, including decreased locomotion, motor skills and muscle strength, hypotonia, dyspnea, kyphosis and convulsions. The EO was lethal at a dose of 2500 mg/kg. Animals receiving 1000 mg/kg were euthanized at the end of the treatment period and their blood and livers were collected for analysis. Mice exposed to L. alba EO presented signifcantly greater plasma alanine aminotransferase (ALT activities than the control group. Liver histological changes included mild infammation, in particular, an increase in nuclear size. Compared to vehicle control group, changes in expression for selected genes were signifcant for FABP5, a fatty acid transport related gene. In summary, the intraperitoneal administration of L. alba EO (citral chemotype causes neurological damage in mice at doses equal or greater than 1500 mg/kg, whereas at 1000 mg/kg, it generates mild liver damage. Therefore, the systemic use of this EO raises concerns about its safety.El aceite esencial (AE de Lippia alba (Mill. NE Brown (Verbenaceae ha sido utilizado tradicionalmente para tratar varias enfermedades. En este estudio, los efectos tóxicos agudos del AE de Lippia alba quimiotipo citral fueron evaluados en ratones. Los animales fueron tratados por vía intraperitoneal recibiendo el AE en dosis entre 50 y 2500 mg/kg de peso, y el grupo control aceite de sésamo (vehículo. Dosis superiores a 1000 mg/kg del AE mostraron efectos neurotóxicos incluyendo disminución de la locomoción e hipotonía, disnea, cifosis y

  10. Biogenic volatile organic compounds (BVOCs) emissions from Abies alba in a French forest.

    Science.gov (United States)

    Moukhtar, S; Couret, C; Rouil, L; Simon, V

    2006-02-01

    Air quality studies need to be based on accurate and reliable data, particularly in the field of the emissions. Biogenic emissions from forests, crops, and grasslands are now considered as major compounds in photochemical processes. Unfortunately, depending on the type of vegetation, these emissions are not so often reliably defined. As an example, although the silver fir (Abies alba) is a very widespread conifer tree in the French and European areas, its standard emission rate is not available in the literature. This study investigates the isoprene and monoterpenes emission from A. alba in France measured during the fieldwork organised in the Fossé Rhénan, from May to June 2003. A dynamic cuvette method was used. Limonene was the predominant monoterpene emitted, followed by camphene, alpha-pinene and eucalyptol. No isoprene emission was detected. The four monoterpenes measured showed different behaviours according to micrometeorological conditions. In fact, emissions of limonene, alpha-pinene and camphene were temperature-dependant while eucalyptol emissions were temperature and light dependant. Biogenic volatile organic compounds emissions were modeled using information gathered during the field study. Emissions of the three monoterpenes previously quoted were achieved using the monoterpenes algorithm developed by Tingey et al. (1980) [Tingey D, Manning M, Grothaus L, Burns W. Influence of light and temperature on monoterpene emission rates from slash pine. Plant Physiol 1980;65: 797-801.] and the isoprene algorithm [Guenther, A., Monson, R., Fall, R., 1991. Isoprene and monoterpene emission rate variability: observations with eucalyptus and emission rate algorithm development. J Geophys Res 26A: 10799-10808.]; [Guenther, A., Zimmerman, P., Harley, P., Monson, R., Fall, R., 1993. Isoprene and monoterpene emission rate variability: model evaluation and sensitivity analysis. J Geophys Res 98D: 12609-12617.]) was used for the eucalyptol emission. With these

  11. Morteros de albañilería con escombros de demolición

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    Álvarez Cabrera, J. L.

    1997-06-01

    Full Text Available The possibility of recycling construction rubble, its technical and economic effectiveness, and the social and ecological impact they provide for our society is the reason and the starting point for an optimal exploitation of this aggregate in the manufacture of masonry mortar, since it has the same inherent properties as those obtained from the quarry aggregates, described in the Cuban standard NC52-79:93. The work consists in the preparation and study of masonry mortars using recycled aggregates -demolition product-. Four volumetric dosages were prepared (1:4; 1:5; 1:6 y 1:8, which were submitted to physical and mechanical tests at 7, 28 and 60 days, adherence resistance at 28 days, and capillary absorption, obtaining similar results to those.

    La posibilidad real del reciclaje de escombros, su efectividad técnica, económica, y el impacto social y ecológico que proporciona a la sociedad, es nuestro punto de partida para lograr un óptimo aprovechamiento de este árido como futuro agregado fundamental en la obtención de un mortero de albañilería, capaz de tener como propiedades aquellas intrínsecas de los propios morteros obtenidos a partir de áridos de cantera y recogidos en la norma cubana NC52-79:93. El trabajo consiste en la preparación y estudio de morteros de albañilería empleando árido reciclado -producto de demolición- como agregado. Se prepararon 4 dosificaciones volumétricas (1:4; 1:5; 1:6 y 1:8, las cuales fueron sometidas a ensayos físico-mecánicos al, 28 y 60 días, resistencia a la adherencia a 28 días, y absorción capilar, obteniéndose resultados comparables con los morteros de albañilería tradicionales.

  12. Overlapping toxic effect of long term thallium exposure on white mustard (Sinapis alba L.) photosynthetic activity.

    Science.gov (United States)

    Mazur, Radosław; Sadowska, Monika; Kowalewska, Łucja; Abratowska, Agnieszka; Kalaji, Hazem M; Mostowska, Agnieszka; Garstka, Maciej; Krasnodębska-Ostręga, Beata

    2016-09-02

    Heavy metal exposure affect plant productivity by interfering, directly and indirectly, with photosynthetic reactions. The toxic effect of heavy metals on photosynthetic reactions has been reported in wide-ranging studies, however there is paucity of data in the literature concerning thallium (Tl) toxicity. Thallium is ubiquitous natural trace element and is considered the most toxic of heavy metals; however, some plant species, such as white mustard (Sinapis alba L.) are able to accumulate thallium at very high concentrations. In this study we identified the main sites of the photosynthetic process inhibited either directly or indirectly by thallium, and elucidated possible detoxification mechanisms in S. alba. We studied the toxicity of thallium in white mustard (S. alba) growing plants and demonstrated that tolerance of plants to thallium (the root test) decreased with the increasing Tl(I) ions concentration in culture media. The root growth of plants exposed to Tl at 100 μg L(-1) for 4 weeks was similar to that in control plants, while in plants grown with Tl at 1,000 μg L(-1) root growth was strongly inhibited. In leaves, toxic effect became gradually visible in response to increasing concentration of Tl (100 - 1,000 μg L(-1)) with discoloration spreading around main vascular bundles of the leaf blade; whereas leaf margins remained green. Subsequent structural analyses using chlorophyll fluorescence, microscopy, and pigment and protein analysis have revealed different effects of varying Tl concentrations on leaf tissue. At lower concentration partial rearrangement of the photosynthetic complexes was observed without significant changes in the chloroplast structure and the pigment and protein levels. At higher concentrations, the decrease of PSI and PSII quantum yields and massive oxidation of pigments was observed in discolored leaf areas, which contained high amount of Tl. Substantial decline of the photosystem core proteins and disorder of the

  13. The instrumentation of informatics curricular strategy in the subject Algebra I in Mathematic – Physics career.

    Directory of Open Access Journals (Sweden)

    Neisy Rodríguez Morales

    2014-03-01

    Full Text Available The article shows the theoretical elements related with the conception of the curricular strategies and its instrumentation in the process of the student's of the Mathematical career formation - Physics. Examples are presented that demonstrate how to deal with the computer science's curricular strategy from the teaching process - learning of the subject Algebra I in the third year of the career. They give the possibility that the formation process be more effective, they facilitate the systematizing knowledge and abilities as well as the development of the integral general culture in the future professors of Mathematics - Physics.

  14. EXPERIENCIA SUBJETIVA DE ESTUDIANTES Y DOCENTES QUE VIVENCIAN UN CAMBIO CURRICULAR

    OpenAIRE

    Rivas R, Edith; Bustos M, Luis; Rivas L, Ángélica; Lagos P, Ximena; San Martín G, Silvia

    2012-01-01

    Objetivo: Conocer la experiencia subjetiva de estudiantes y docentes respecto del cambio curricular. Metodología: Estudio transversal, muestra de 169 estudiantes de cuarto año curricular y 32 docentes. Información recogida en cuestionario “Inquietudes y procedimientos para adoptar Innovaciones Educativas” (IPIE) validado y adaptado al estudio. Análisis descriptivo. Estudio respetó normas éticas y consentimiento informado. Resultados: 26,0% de alumnos correspondió a Tecnología Médica; 22,5% En...

  15. Investigación-acción en el desarrollo de proyectos curriculares innovadores de ciencias

    OpenAIRE

    Membiela, Pedro

    2002-01-01

    Un grupo de investigación-acción ha diseñado dos proyectos curriculares innovadores de ciencias para enseñanza secundaria, que tienen como meta fundamental la relevancia social y personal. El proceso de construcción curricular en la práctica ha estado orientado por la evaluación holística centrada en la mejora educativa, consiguiendo una valoración positiva por parte de los implicados. El análisis en profundidad de las condiciones educativas existentes y el uso de la investigación para el cam...

  16. About Extra-Curricular Activities of The University Graduate – Student’s Viewpoint

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    Ivanova Veronica

    2017-01-01

    Full Text Available Extra-curricular activity of modern youth, including university students, is considered to reduce. Students are thought to demonstrate consumer’s attitude, unwillingness to participate in any social activity, and as a result, the level of soft skills acquired by university students is decreasing. The study of social activity of 100 Bachelor graduates from TPU, including the program “Electrical engineering”, indicated the role of the university in creation of conditions for competence development during training of students according to individual educational trajectory and development of their social (extra-curricular activity.

  17. La hacienda de los duques de Alba en el siglo XV : ingresos y gastos

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    José Manuel Calderón Ortega

    1996-01-01

    Full Text Available Años atrás, aparecía en la Revista «Hispania» un trabajo sobre la Hacienda de los duques de Alba. Entonces, el objeto de atención fue el estudio del elemento personal, es decir, los oficiales, al tiempo que la evolución de la institución a lo largo de los siglos xv y xvi, los más destacados en la historia de cualquiera de ios grandes estados señoriales de la «Nobleza Nueva», correspondientes lógicamente al nacimiento, desarrollo y consolidación de sus órganos de gobierno y administración.

  18. Production capacity of biomass of the floodpain community of Salix alba L. in southern Moravia

    Directory of Open Access Journals (Sweden)

    Diana López

    2007-01-01

    Full Text Available The paper deals with the study of the production capacity of biomass in the seven-year stand of Salix alba L. The communities originated in the process of primary succession in the area of the middle Nové Mlýny reservoir on a newly established island. Already since the first stages, the communities have been monitored. Results have shown that white willow behaves as an R-strategist with fast growth in youth. Moreover, the growth is supported by optimum environmental conditions (soils richly supplied with nutrients and water, long growing season. Accumulated phytomass amounted 102,7 t.ha−1 at the age of 7 years and the yield reached a mean annual increment of 15 t.ha−1.year−1. Communities of white willow rank among highly productive phytocoenoses capable of fixing considerable amounts of carbon and, at the same time fulfilling the function of habitat corridors.

  19. Prey selection by the Barn Owl Tyto alba (Scopoli, 1769 in captivity

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    V. Vanitha

    2009-07-01

    Full Text Available We investigated prey selection of the Barn Owl Tyto alba under captive conditions where birds were allowed to choose among individuals of varying size from four field rodent species: Bandicota bengalensis, Millardia meltada, Tatera indica and Mus booduga. Owls showed little species preference and a tendency to favour the medium weight class in all prey species except M. booduga. Preference for body parts consumed varied according to prey size, ranging from the head alone in the large weight class to the entire body in the small weight class. Biochemical measurements showed that protein, carbohydrate and lipid levels were higher respectively in the brain, liver and muscles of all three species and weight classes studied. The preference for medium weight prey despite a lower nutrient content compared to large weight prey is attributed to a greater ease of capture.

  20. Winter season corticular photosynthesis in Cornus florida, Acer rubrum, Quercus alba, and Liriodendron tulipifera

    International Nuclear Information System (INIS)

    Coe, J.M.; McLaughlin, S.B.

    1980-01-01

    Winter season corticular photosynthesis was studied in four species of deciduous trees: dogwood (Cornus florida), red maple (Acer rubrum), white oak (Quercus alba), and yellow-poplar (Liriodendron tulipifera). Techniques included measuring CO 2 uptake at varying light intensities, relating the apparent photosynthetic capacities to seasonal changes in chlorophyll content of twigs and determining the fate of assimilated carbon over time. Dogwood was the most photosynthetically active of the four species studied; however, gross photosynthesis did not exceed respiration in any of the four species. Photosynthetic activity of dogwood twigs was estimated at 10% of that of dogwood leaves on a weight basis and 85% on a surface area basis. Photosynthetic activity was generally related to shade tolerance ranking and was on the order of dogwood much greater than red maple much greater than white oak approx. = yellow-poplar. Little change in chlorophyll content occurred over the January-April 1979 study interval

  1. Habitar íntimo: a poesia de Eduardo Dall’Alba

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    Vera Lúcia de Oliveira

    2014-06-01

    Full Text Available Eduardo Dall’Alba (1963-2013 ha pubblicato oltre dieci libri, tra saggi e poesia, ed ha ricevuto diversi premi. Appartiene ad una famiglia di emigranti veneti stabilitosi del Rio Grande do Sul alla fine dell’Ottocento. È un profondo conoscitore della letteratura italiana, studioso di Dante, Eduardo è riuscito a fondere le due culture e identità, quella brasiliana a quella italiana. Qui desidero enfatizzare come la poesia di quest’autore recupera il vissuto rimosso e senza voce di migliaia di italiani emigrati al sud del Brasile, con il loro dolore e la loro frustrazione per aver abbandonato la propria terra, la nostalgia e l’ossessione di autosufficienza economica che si otteneva tramite il lavoro incessante di tutti i componenti della famiglia, il cui dialetto – o dialetti – erano visti quale elemento agglutinante delle prime comunità.

  2. Fatty acids composition of Spanish black (Morus nigra L.) and white (Morus alba L.) mulberries.

    Science.gov (United States)

    Sánchez-Salcedo, Eva M; Sendra, Esther; Carbonell-Barrachina, Ángel A; Martínez, Juan José; Hernández, Francisca

    2016-01-01

    This research has determined qualitatively and quantitatively the fatty acids composition of white (Morus alba) and black (Morus nigra) fruits grown in Spain, in 2013 and 2014. Four clones of each species were studied. Fourteen fatty acids were identified and quantified in mulberry fruits. The most abundant fatty acids were linoleic (C18:2), palmitic (C16:0), oleic (C18:1), and stearic (C18:0) acids in both species. The main fatty acid in all clones was linoleic (C18:2), that ranged from 69.66% (MN2) to 78.02% (MA1) of the total fatty acid content; consequently Spanish mulberry fruits were found to be rich in linoleic acid, which is an essential fatty acid. The fatty acid composition of mulberries highlights the nutritional and health benefits of their consumption. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. Four New Flavonoids with α-Glucosidase Inhibitory Activities from Morus alba var. tatarica.

    Science.gov (United States)

    Zhang, Ya-Long; Luo, Jian-Guang; Wan, Chuan-Xing; Zhou, Zhong-Bo; Kong, Ling-Yi

    2015-11-01

    Four new flavonoids, mortatarins A-D (1-4, resp.), along with eight known flavonoids (5-12) were isolated from the root bark of Morus alba var. tatarica. Their structures were established on the basis of spectroscopic data analysis, and the absolute configuration of 4 was determined by analysis of its CD spectrum. All isolates were tested for inhibitory activities against α-glucosidase. Compounds 4, 7, and 8 exhibited a significant degree of inhibition with IC50 values of 5.0 ± 0.3, 7.5 ± 0.5, and 5.9 ± 0.2 μM, respectively. Copyright © 2015 Verlag Helvetica Chimica Acta AG, Zürich.

  4. New cytotoxic and anti-inflammatory compounds isolated from Morus alba L.

    Science.gov (United States)

    Qin, Jing; Fan, Min; He, Juan; Wu, Xing-De; Peng, Li-Yan; Su, Jia; Cheng, Xiao; Li, Yan; Kong, Ling-Mei; Li, Rong-Tao; Zhao, Qin-Shi

    2015-01-01

    Six Diels-Alder adducts (1-6) and nine prenylated flavanones (7-15) were isolated from the root bark of Morus alba L. Among them, soroceal B (1) and sanggenol Q (7) were new compounds. Their structures were elucidated on the basis of extensive spectroscopic methods, including 1D and 2D NMR techniques. Compounds 1-3, 9, 10, 12, 13 and 15 exhibited cytotoxic activity against five human tumour lines and compound 2 inhibited significantly selective cytotoxic activities towards HL-60 and AGS cells with IC50 of 3.4 and 3.6 μM. Compounds 3, 5, 9 and 12 exhibited moderate inhibitory activity against nitric oxide production in LPS-activated RAW264.7.

  5. Antidiabetic and Antioxidant Effects and Phytochemicals of Mulberry Fruit (Morus alba L.) Polyphenol Enhanced Extract

    Science.gov (United States)

    Wang, Yihai; Xiang, Limin; Wang, Chunhua; Tang, Chao; He, Xiangjiu

    2013-01-01

    The antidiabetic and antioxidant activities of the ethyl acetate-soluble extract (MFE) of mulberry fruit (Morus alba L.) were investigated. In vitro, MFE showed potent α-glucosidase inhibitory activity and radical-scavenging activities against DPPH and superoxide anion radicals. In vivo, MFE could significantly decrease fasting blood glucose (FBG) and glycosylated serum protein (GSP), and increase antioxidant enzymatic activities (SOD, CAT, GSH-Px) in streptozotocin (STZ)-induced diabetic mice. Bioactivity-guided fractionation of the MFE led to the isolation of 25 phenolic compounds, and their structures were identified on the basis of MS and NMR data. All the 25 compounds were isolated from mulberry fruit for the first time. Also, the α-glucosidase inhibitory activity and antioxidant activity of the phenolics were evaluated. Potent α-glucosidase inhibitory and radical-scavenging activities of these phenolics suggested that they may be partially responsible for the antidiabetic and antioxidant activities of mulberry fruit. PMID:23936259

  6. Effects of Applied Nitrogen Amounts on the Functional Components of Mulberry (Morus alba L.) Leaves.

    Science.gov (United States)

    Sugiyama, Mari; Takahashi, Makoto; Katsube, Takuya; Koyama, Akio; Itamura, Hiroyuki

    2016-09-21

    This study investigated the effects of applied nitrogen amounts on specific functional components in mulberry (Morus alba L.) leaves. The relationships between mineral elements and the functional components in mulberry leaves were examined using mulberry trees cultivated in different soil conditions in four cultured fields. Then, the relationships between the nitrogen levels and the leaf functional components were studied by culturing mulberry in plastic pots and experimental fields. In the common cultured fields, total nitrogen was negatively correlated with the chlorogenic acid content (R(2) = -0.48) and positively correlated with the 1-deoxynojirimycin content (R(2) = 0.60). Additionally, differences in nitrogen fertilizer application levels affected each functional component in mulberry leaves. For instance, with increased nitrogen levels, the chlorogenic acid and flavonol contents significantly decreased, but the 1-deoxynojirimycin content significantly increased. Selection of the optimal nitrogen application level is necessary to obtain the desired functional components from mulberry leaves.

  7. Two novel compounds from the root bark of Morus alba L.

    Science.gov (United States)

    Li, Ming; Wu, Xuewei; Wang, Xiaoning; Shen, Tao; Ren, Dongmei

    2018-01-01

    Chemical investigation of the root bark of Morus alba led to the isolation of a new flavone, dioxycudraflavone A (1) and a new 2-arylbenzofuran, 5-hydroxyethyl moracin M (2), together with seven known compounds namely sanggenon V (3), morusin (4), morusignin L (5), licoflavone C (6), moracin C (7), alfafuran (8) and mulberrofuran G (9). The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D, 2D NMR and HR-ESI-MS. All compounds were evaluated for the α-glucosidase inhibitory and cytotoxic activities. Compounds 2-4, 8 and 9 exhibited strong α-glucosidase inhibitory activities with IC 50 less than 10 μM, while only 4 and 9 showed moderate cytotoxic effects against lung cancer cells.

  8. The use of the white poplar (Populus alba L.) biomass as fuel

    Institute of Scientific and Technical Information of China (English)

    Tatiana Griu; Aurel Lunguleasa

    2016-01-01

    We determined the calorific value of white poplar (Populus alba L.) woody biomass to use it as fire-wood. The value of 19.133 MJ kg-1 obtained experimen-tally shows that the white poplar can be quite successfully used as firewood. Being of a lower quality in comparison with usual beech firewood, the white poplar has similar calorific value. The white poplar has a calorific density of 30.7%lower than that of current firewood. That is why the price of this firewood from white poplar is lower accord-ingly. Also, the prognosis of calorific value on the basis of the main chemical elements, being very close to the experimental value (?2.6%), indicates an appropriate value can be achieved to be used for investigation with the chemical element analysis.

  9. Pedestrian Zones As Important Urban Strategies in Redeveloping the Community - Case Study: Alba Iulia Borough Park

    Directory of Open Access Journals (Sweden)

    Oana Elena BLAGA

    2013-02-01

    Full Text Available The pedestrian zone issue is by far an important matter in the context of urban regeneration. Cities which adopted this strategy – the pedestrian zones – have recorded better urban attitudes regarding the urban environment, a continuous growth of the urban quality, an improved urban ecosystem  and continuous attractiveness for investment and  tourism. This article explores the evolution of the pedestrian zones as ideas in utopian urban models in the early 1900 and later as efficient environmental friendly strategies adopted by cities. After identifying the path this concept followed, from a simple idea to an important strategy of urban development, the paper focuses on the major characteristics and benefits of the pedestrian precincts. Next, the article focuses on the newest pedestrian zone in one of the Romanian cities, Alba Iulia and it tries to identify the types of impact this area has so far on the community and entire city.

  10. Laser effects on the growth and photosynthesis process in mustard plants (Sinapis Alba)

    Science.gov (United States)

    Anghel, Sorin; Stanescu, Constantin S.; Giosanu, Dana; Flenacu, Monica; Iorga-Siman, Ion

    2001-06-01

    In this paper we present the results of our experiments concerning the influence of the low energy laser (LEL) radiation on the germination, growth and photosyntheses processes in mustard plants (sinapis alba). We used a He-Ne laser ((lambda) equals 632.8 nm, P equals 6 mW) to irradiate the mustard seeds with different exposure times. The seeds were sowed and some determinations (the germination and growth intensity, chlorophyll quantity, and respiration intensity) were made on the plant culture. We ascertained that the germination and growth of the plants are influenced by the irradiation. Also, the chlorophyll quantity is the same for both plants from irradiated and non-irradiated seeds but the respiration and photosynthesis processes are influenced by the irradiation.

  11. Antidiabetic and antioxidant effects and phytochemicals of mulberry fruit (Morus alba L. polyphenol enhanced extract.

    Directory of Open Access Journals (Sweden)

    Yihai Wang

    Full Text Available The antidiabetic and antioxidant activities of the ethyl acetate-soluble extract (MFE of mulberry fruit (Morus alba L. were investigated. In vitro, MFE showed potent α-glucosidase inhibitory activity and radical-scavenging activities against DPPH and superoxide anion radicals. In vivo, MFE could significantly decrease fasting blood glucose (FBG and glycosylated serum protein (GSP, and increase antioxidant enzymatic activities (SOD, CAT, GSH-Px in streptozotocin (STZ-induced diabetic mice. Bioactivity-guided fractionation of the MFE led to the isolation of 25 phenolic compounds, and their structures were identified on the basis of MS and NMR data. All the 25 compounds were isolated from mulberry fruit for the first time. Also, the α-glucosidase inhibitory activity and antioxidant activity of the phenolics were evaluated. Potent α-glucosidase inhibitory and radical-scavenging activities of these phenolics suggested that they may be partially responsible for the antidiabetic and antioxidant activities of mulberry fruit.

  12. Postremediation dose assessment for the former Alba Craft Laboratory site, Oxford, Ohio

    International Nuclear Information System (INIS)

    Kamboj, S.; Nimmagadda, M.; Yu, C.

    1996-04-01

    Potential maximum radiation dose rates were calculated for the former Alba Craft Laboratory site in Oxford, Ohio, which was involved in machining of uranium metal in the 1950s for the U.S. atomic energy program. The site is not currently being used. The residual radioactive material guidelines (RESRAD) computer code, which implements the methodology described in the US Department of Energy's (DOE's) manual for establishing residual radioactive material guidelines, was sued in this evaluation. Three potential land use scenarios were considered for the former Alba Craft site; the scenarios vary with regard to the type of site use, time spent at the site by the exposed individual, and sources of food consumed. Scenario A (a possible land use scenario) assumed industrial use of the site; Scenario B (a likely future land use scenario) assumed residential use of the site; and Scenario C (a possible but unlikely land use scenario) assumed the presence of a resident farmer. For scenario A, it was assumed that any water used for domestic or industrial activities would be from uncontaminated off-site municipal sources. The water used for drinking, household purposes, and irrigation was assumed to be from uncontaminated municipal sources in Scenario B; groundwater drawn from a well located at the downgradient edge of the contaminated zone would be the only source of water for drinking, irrigation, and raising livestock in Scenario C. The results of the evaluation indicated that the DOE dose limit of 100 mrem/yr would not be exceeded for any of the scenarios analyzed. The potential maximum dose rates for Scenarios A, B, and C are 0.64, 2.0, and 11 mrem/yr, respectively

  13. Isoprenylated flavonoids from the root bark of Morus alba and their hepatoprotective and neuroprotective activities.

    Science.gov (United States)

    Jung, Jae-Woo; Ko, Won-Min; Park, Ji-Hae; Seo, Kyeong-Hwa; Oh, Eun-Ji; Lee, Dae-Young; Lee, Dong-Sung; Kim, Youn-Chul; Lim, Dong-Wook; Han, Daeseok; Baek, Nam-In

    2015-11-01

    A new isoprenylated flavonoid, 2S-5,7,2',4'-tetrahydroxy-3',5'-di-(γ,γ-dimethylallyl)flavanone, sanggenol Q (1), along with seven known isoprenylated flavonoids, sanggenol A (2), sanggenol L (3), kuwanon T (4), cyclomorusin (5), sanggenon F (6), sanggenol O (7), and sanggenon N (8), three known Diels-Alder type adducts, sanggenon G (9), mulberrofuran G (10), and mulberrofuran C (11), and a known benzofuran, moracin E (12), were isolated from the root bark of Morus alba using silica gel, ODS, and Sephadex LH-20 column chromatography. Chemical structures were determined based on spectroscopic data analyses including NMR, MS, CD, and IR. For the first time, compounds 1 and 7 were isolated from the root bark of M. alba. All compounds were evaluated for hepatoprotective activity on t-BHP-induced oxidative stress in HepG2 cells and neuroprotective activity on glutamate-induced cell death in HT22 cells. Compounds 1, 4, 8, 10, and 11 showed protective effects on t-BHP-induced oxidative stress with EC50 values of 6.94 ± 0.38, 30.32 ± 6.82, 23.45 ± 4.72, 15.31 ± 2.21, and 0.41 ± 0.48 μM, respectively, and compounds 1, 2, 10, 11, and 12 showed protective effects on glutamate-induced cell death with EC50 values of 5.54 ± 0.86, 34.03 ± 7.71, 19.71 ± 0.71, 16.50 ± 7.82, and 1.02 ± 0.13 μM, respectively.

  14. Ocorrência de Halysidota orientalis Rothschild (Lepidoptera: Arctiidae) em amoreira (Morus alba L.) no Estado de São Paulo

    OpenAIRE

    Sánchez-Soto, Saúl; Romano, Fabiana C.B.; Nakano, Octavio

    2004-01-01

    É registrada pela primeira vez a ocorrência de lagartas de Halysidota orientalis Rothschild em plantas de amoreira (Morus alba L.) no estado de São Paulo. Alguns aspectos da morfologia externa do adulto, larva e pupa são descritos. The occurrence of larvae of Halysidota orientalis Rothschild on mulberry plants (Morus alba L.) is recorded for the first time in São Paulo, Brazil. Morphological aspects of adult, larva and pupa are described.

  15. Capra alba Moyà-Solà, 1987 del Pleistoceno Inferior de la Sierra de Quibas (Albanilla, Murcia, España

    Directory of Open Access Journals (Sweden)

    Romero, G.

    2006-12-01

    Full Text Available The first palaeontological study of the locality of Quibas dates from the end of the 1990ties (Montoya et al., 1999, describing over 60 vertebrate taxa. One of these was a caprine assigned to Capra sp. aff. Capra alba. Recent excavations yielded new remains of this taxon, which permits a more profound study of its affinities and an assignation to Capra alba, without reservation. This assignation is based on the morphological and metrical comparison of the skulls, horn cores, dentition and metapodials from Quibas with those of Capra alba from Venta Micena (Orce Granada.A finales de la década de los 90 se realizó el primer estudio paleontológico del yacimiento de la Sierra de Quibas (Montoya et al., 1999 en el que se describieron más de 60 taxones de vertebrados. Uno de ellos fue el de un caprino asignado como Capra sp. aff Capra alba. Las últimas campañas de excavación han librado nuevos restos de este taxón, lo que ha permitido poder estudiarlo con mayor profundidad y asignarlo a Capra alba. Esta atribución se basa en la comparación morfológica y métrica de los cráneos, núcleos óseos, dentición y metápodos con los ejemplares de C. alba de Venta Micena (Orce, Granada.

  16. Antidepressant-like effects of the ethyl acetate soluble fraction of the root bark of Morus alba on the immobility behavior of rats in the forced swim test.

    Science.gov (United States)

    Lim, Dong Wook; Kim, Yun Tai; Park, Ji-Hae; Baek, Nam-In; Han, Daeseok

    2014-06-12

    In this study, the antidepressant-like effects of Morus alba fractions in rats were investigated in the forced swim test (FST). Male Wistar rats (9-week-old) were administered orally the M. alba ethyl acetate (EtOAc 30 and 100 mg/kg) and M. alba n-butanol fractions (n-BuOH 30 and 100 mg/kg) every day for 7 consecutive days. On day 7, 1 h after the final administration of the fractions, the rats were exposed to the FST. M. alba EtOAc fraction at the dose of 100 mg/kg induced a decrease in immobility behavior (p alba EtOAc fraction at the dose of 100 mg/kg decreased the hypothalamic-pituitary-adrenal (HPA) axis response to the stress, as indicated by an attenuated corticosterone response and decreased c-fos immunoreactivity in the hippocampal and hypothalamic paraventricular nucleus (PVN) region. These findings demonstrated that M. alba EtOAc fraction have beneficial effects on depressive behaviors and restore both altered c-fos expression and HPA activity.

  17. Proyecto Grannacional ALBASALUD para Centro Regulador de Medicamentos Esenciales de los países del ALBA-TCP Grand-national Project ALBASALUD for Regulatory Center of Essential Drugs for the ALBA-TCP countries

    Directory of Open Access Journals (Sweden)

    Celeste Aurora Sánchez González

    2011-09-01

    Full Text Available La Autoridad Reguladora de Medicamentos de Cuba, coordina un Proyecto de la Alianza Bolivariana para los pueblos de América-Tratado de Libre Comercio (ALBA-TCP, dirigido al desarrollo de un Centro Regulador para los países del ALBA como nuevo organismo regional de integración farmacéutica, en aras de contar con un Registro Grannacional válido en todos los países partes, como herramienta para facilitar el acceso a medicamentos esenciales de calidad. Esta investigación tuvo como objetivo diseñar y conducir desde el punto de vista técnico un proyecto para crear las bases legales y metodológicas del futuro centro y sus funciones básicas. Se emplearon técnicas de grupo nominal, puntos de referencia, consultas a expertos y se crearon metodologías específicas para planear y confeccionar los documentos necesarios. Se utilizaron lineamientos de organismos reguladores internacionales, cuadros básicos de medicamentos y reglamentación farmacéutica de los países participantes. Se desarrollaron y aplicaron documentos y estrategias para el trabajo del proyecto durante la etapa de preinversión, se definió el primer listado de medicamentos esenciales del ALBA y se aprobaron las fundamentales disposiciones legales y la reglamentación para las funciones de registro, vigilancia, inspecciones, laboratorios y liberación de lotes. El Proyecto Grannacional ALBASALUD "Centro Regulador de Medicamentos del ALBA-TCP" aplicado ha demostrado su eficiencia y capacidad para alcanzar los objetivos trazados mediante un trabajo científico-técnico con participación colectiva, que ha garantizado las disposiciones y lineamientos requeridos para sus funciones básicas y respaldo legal.The Drug Regulatory Authority of Cuba is coordinating a Project of the Bolivarian Alliance for the Peoples of America- Free Trade Agreement (ALBA-TCP aimed at developing a Regulatory Center that will operate as a new regional body of pharmaceutical integration for the ALBA

  18. Updating Classroom Libraries and Cross-Curricular Activities: Celebrating Gender Identity and Diversity through LGBTQ Books

    Science.gov (United States)

    Brand, Susan Trostle; Maasch, Susan L.

    2017-01-01

    By using carefully selected children's literature and related curricular activities, and including parents and community members in information sessions and newsletters, teachers can make a positive difference in the lives of individuals who are transgender and/or those who live in diverse families. As children see positive depictions of children…

  19. La educabilidad: atributo mediacional entre la realidad curricular y organizativa del centro escolar

    Directory of Open Access Journals (Sweden)

    Miguel PÉREZ FERRA

    2009-11-01

    Full Text Available Es evidente, que la actividad de los centros educativos necesita para alcanzar las finalidades que justifican su existencia y trabajo, ser planificada, ordenada, programada, desarrollada y evaluada. Toda esta labor se sintetiza y recoge en el Proyecto de Centro, instrumento de planificación a medio plazo, que concreta y desarrolla los elementos que lo integran: Finalidades educativas, Proyecto curricular de Centro y Reglamento de Organización y Funcionamiento. En este artículo realizamos una reflexión sobre la conveniencia, posibilidad y realidad de utilización con carácter orgánico de dos documentos esenciales en el Proyecto de Centro. Nos referimos al Proyecto Curricular de Centro y al Reglamento de Organización y Funcionamiento. El estudio integra tres perspectivas complementarias: la realidad ontológica o conveniencia de dicha relación que intentamos justificar desde el atributo educabilidad, propio del hombre, nexo de unión entre la esencia de los dos documentos; la realidad histórica de los últimos cincuenta años y su incidencia en la relación organizativo-curricular de los centros; por último, valoramos la trayectoria lineal de la formación del profesorado en España y sus respuestas al centro como unidad organizativa, profesional y curricular.

  20. Evaluating the Implementation of International Computing Curricular in African Universities: A Design-Reality Gap Approach

    Science.gov (United States)

    Dasuki, Salihu Ibrahim; Ogedebe, Peter; Kanya, Rislana Abdulazeez; Ndume, Hauwa; Makinde, Julius

    2015-01-01

    Efforts are been made by Universities in developing countries to ensure that it's graduate are not left behind in the competitive global information society; thus have adopted international computing curricular for their computing degree programs. However, adopting these international curricula seem to be very challenging for developing countries…

  1. Curricular Innovation for Sustainability: The Piedmont/Ponderosa Model of Faculty Development

    Science.gov (United States)

    Barlett, Peggy F.; Chase, Geoffrey W.

    2012-01-01

    Curricular innovation is at the center of the challenges many colleges and universities face as they seek to help students address more successfully than previous generations the complex, multi-faceted, systemic challenges of global climate change, population growth, loss of biodiversity, environmental justice, toxic wastes, and food insecurity.…

  2. How Do Tertiary Education Students Perceive Co-Curricular Activities under the New Education System?

    Science.gov (United States)

    Wong, Helen; Leung, Simon

    2018-01-01

    Co-curricular activities in general are believed to be useful for students' development, such as improvement in academic performance, higher retention rate, enhancement of social and competency skills, and assistance of youth development and employment. With the expansion of the education sector and the implementation of a new 3-3-4 education…

  3. Curricular Space Allocated for Dance Content in Physical Education Teacher Education Programs: A Literature Review

    Science.gov (United States)

    Marquis, Jenée Marie; Metzler, Mike

    2017-01-01

    This literature review examines curricular space allocated to activity based/movement content courses in Physical Education Teacher Education (PETE) pre-service programs, specifically focusing on how dance content knowledge and pedagogical content knowledge are addressed within those programs. This review includes original empirical research…

  4. A Cross-Curricular, Problem-Based Project to Promote Understanding of Poverty in Urban Communities

    Science.gov (United States)

    Gardner, Daniel S.; Tuchman, Ellen; Hawkins, Robert

    2010-01-01

    This article describes the use of problem-based learning to teach students about the scope and consequences of urban poverty through an innovative cross-curricular project. We illustrate the process, goals, and tasks of the Community Assessment Project, which incorporates community-level assessment, collection and analysis of public data, and…

  5. The Play Curricular Activity Reflection Discussion Model for Game-Based Learning

    Science.gov (United States)

    Foster, Aroutis; Shah, Mamta

    2015-01-01

    This article elucidates the process of game-based learning in classrooms through the use of the Play Curricular activity Reflection Discussion (PCaRD) model. A mixed-methods study was conducted at a high school to implement three games with the PCaRD model in a year-long elective course. Data sources included interviews and observations for…

  6. South Korean Elementary School Teachers' Perceptions of Professional Curricular Autonomy

    Science.gov (United States)

    Min, Mina

    2017-01-01

    With increasingly diverse formal education settings around the globe, teachers' ability to differentiate curriculum is essential to meet the needs of students with varied cultural, socioeconomic, racial, and linguistic backgrounds. Teachers' curricular autonomy is a prerequisite to diversify curriculum. Guided by sociocultural approaches to agency…

  7. The Russian Federation Islamic Republic of Dagestan: Curricular Decentralization, Social Cohesion, and Stability

    Science.gov (United States)

    Eaton, Jana Sackman

    2005-01-01

    This article focuses on the curricular decentralization-sociopolitical stability nexus in the predominantly Muslim Russian Federation Republic of Dagestan, adjacent to war-torn Chechnya. Concomitant with the metamorphoses taking place in the economic and political sectors of society is the overhaul of institutionalized education. A major reform…

  8. The Curricular Value of Teaching about Immigration through Picture Book Thematic Text Sets

    Science.gov (United States)

    Bersh, Luz Carime

    2013-01-01

    This article offers a contextual analysis of contemporary immigration issues impacting the institutions in the United States, in particular the school. It discusses the importance of addressing this theme in the classroom and presents its curricular value in the elementary and middle school social studies and interdisciplinary curricula. Using a…

  9. Sports Business Unit Meets Cross-Curricular Learning Goals: Grades 9-12

    Science.gov (United States)

    Curriculum Review, 2006

    2006-01-01

    A new online learning tool called the eCommSports Kit links a seven-step sports marketing curriculum with a school team to give students real-life experience in developing and executing a plan to boost game attendance. The kit, available through http://www.ecommsports.com, takes teens on a cross-curricular journey through conducting business…

  10. Developing Standards-Based Geography Curricular Materials from Overseas Field Experiences for K-12 Teachers

    Science.gov (United States)

    Oberle, Alex; Palacios, Fabian Araya

    2012-01-01

    Overseas experiences provide educators with exceptional opportunities to incorporate field study, firsthand experiences, and tangible artifacts into the classroom. Despite this potential, teachers must consider curricular standards that direct how such international endeavors can be integrated. Furthermore, geography curriculum development is more…

  11. Using Instruments for Tactical Assessment in Physical Education and Extra-Curricular Sports

    Science.gov (United States)

    Arias-Estero, José; Castejón, Francisco

    2014-01-01

    The aim was to analyse the features concerning the applicational purpose and strategy of the most common instruments used to assess game tactics both in Physical Education (PE) and in extra-curricular sport contexts. The review focused on two instruments: the Game Performance Assessment Instrument (GPAI) and the Team Sport Assessment Procedure…

  12. Curricular Treatment of Body Image, Self-Esteem and Self-Concept in Spain

    Science.gov (United States)

    Rodríguez, Antonio V.; Estévez, Manuel; Palomares, Juan

    2015-01-01

    Adolescence is a period of human development in which problems with the perception of body image, self-esteem and self-concept proliferate, while the child is studying for Secondary Education. This study analyses the curricular treatment given to body image, self-esteem and self-concept in different legislative elements in the region of Valencia…

  13. Australian Primary Students' Motivation and Learning Intentions for Extra-Curricular Music Programmes

    Science.gov (United States)

    Ng, Clarence

    2017-01-01

    What are the motivational differences between students who intend to continue their learning in instrumental and choral music programmes and those who intend to discontinue? Using an achievement-goal perspective, this study investigated motivation and learning intentions of Australian students who had engaged in these extra-curricular music…

  14. Investigation of Participation Motivations in Exercises of Students Participating in Archery in Extra Curricular Activities

    Science.gov (United States)

    Gündüz, Nevin; Keskin, Muzaffer Toprak; Erdugan, Fuat

    2017-01-01

    The aim of this research is to investigate Investigation of Participation Motivations in Exercises of Students Participating in Archery in Extra Curricular Activities. While the study's universe consists of all 11th graders studying at High school, the sample includes 32 of the 11th grade students who participated in arrow shooting activities in…

  15. Engaging Undergraduate Students in a Co-Curricular Digital Badging Platform

    Science.gov (United States)

    Coleman, Jonathan D.

    2018-01-01

    Digital badging continues to garner attention in the educational community. What remains to be seen is how badging will interact with traditional curricular elements. While concerns have been raised about using badges as extrinsic motivators in coursework, there are alternate areas of application for digital badging. Badges may actually serve to…

  16. Curricular Ethics in Early Childhood Education Programming: A Challenge to the Ontario Kindergarten Program

    Science.gov (United States)

    Heydon, Rachel M.; Wang, Ping

    2006-01-01

    Through a case study of a key Canadian early childhood education program, The Kindergarten Program (Ontario Ministry of Education and Training, 1998a), we explore the relationship between curricular paradigms and early childhood education (ECE) models, and the opportunities that each creates for enacting ethical teaching and learning…

  17. Exploring the Effectiveness of a Curricular Choice Majors Program on Teacher Motivation

    Science.gov (United States)

    VanDeusen Gaddis, Linda Marie

    2014-01-01

    The purpose of this qualitative case study was to explore how a curricular choice majors program influenced teacher motivation and student performance at a charter high school in Pennsylvania from the perception of the administration and teachers. The theoretical foundation for this study was the attribution motivation theory. This theory…

  18. Extra-Curricular and out-of-School Education in European Socialist Countries.

    Science.gov (United States)

    Wegerich, Hans-Joachim

    1988-01-01

    Describes extra-curricular activities in East Germany, Bulgaria, Czechoslovakia, Poland, Romania, and the USSR, and provides an annotated bibliography that covers activities in the social sciences; science and technology; natural sciences; arts and culture; sports; tourism; mass media; after school centers; holiday activities; and youth…

  19. Humanism's Sisyphean Task: Curricular Reform at Brown University during the Second World War

    Science.gov (United States)

    Porwancher, Andrew

    2011-01-01

    In the midst of a curricular debate at Brown University during the Second World War, the faculty's humanists seized the opportunity to pen their views on the nature and purpose of higher education. This investigation reveals humanism as a fragmented force, at once principal and peripheral to the American academy. The central argument of this study…

  20. The Ontological Architectures in the Application of a Knowledge Management System for Curricular Assessment

    Science.gov (United States)

    Olson, Brandon D.

    2012-01-01

    Institutions of higher education are facing increasing pressure to improve the effectiveness and quality of academic programs (Association of Governing Boards, Top public policy issues 2011-2012, 2011). These institutions apply curricular assessment processes as a means to evaluate and improve academic effectiveness and quality. Knowledge…

  1. Effects of Curricular Activity on Students' Situational Motivation and Physical Activity Levels

    Science.gov (United States)

    Gao, Zan; Hannon, James C.; Newton, Maria; Huang, Chaoqun

    2011-01-01

    The purpose of this study was to examine (a) the effects of three curricular activities on students' situational motivation (intrinsic motivation [IM], identified regulation [IR], external regulation, and amotivation [AM]) and physical activity (PA) levels, and (b) the predictive strength of situational motivation to PA levels. Four hundred twelve…

  2. "Teachosaurus" and "Learnoceratops": Dinosaurs as a Motivating Cross-Curricular Theme

    Science.gov (United States)

    Duggan, Denis

    2011-01-01

    The author takes a look into the benefits that dinosaurs may bring to the classroom. He discusses how he used dinosaurs as a cross-curricular theme to improve children's understanding and knowledge of science concepts. To investigate what a child might learn from dinosaurs, he started by comparing the many non-fiction dinosaur books using the…

  3. Digital "Learning Trails": Scaling Technology-Facilitated Curricular Innovation in Schools with a "Rhizomatic" Lens

    Science.gov (United States)

    Jamaludin, Azilawati; Hung, David Wei Loong

    2016-01-01

    Technological advances in the form of ubiquitous computing has altered the learning landscape today. Contemporary modes of learning afford curricular innovations in schools. While learning journeys of decades ago entailed field trips to places of interest such as museums and zoos where students completed tasks or worksheets after each trip, the…

  4. Curricular Transformation of Education in the Field of Physical and Sport Education in Slovakia

    Science.gov (United States)

    Bendíková, Elena

    2016-01-01

    The study presents basic information on the curricular transformation of physical and sport education in Slovakia after the year 1989, which is related to the education process in the 21st century. What is more, it points to the basis for modern transformation in relation to sports as well as to insufficient undergraduate teacher training and its…

  5. Students' Use of Extra-Curricular Activities for Positional Advantage in Competitive Job Markets

    Science.gov (United States)

    Roulin, Nicolas; Bangerter, Adrian

    2013-01-01

    With the rise of mass higher education, competition between graduates in the labour market is increasing. Students are aware that their degree will not guarantee them a job and realise they should add value and distinction to their credentials to achieve a positional advantage. Participation in extra-curricular activities (ECAs) is one such…

  6. The Relationship of IEP Quality to Curricular Access and Academic Achievement for Students with Disabilities

    Science.gov (United States)

    La Salle, Tamika P.; Roach, Andrew T.; McGrath, Dawn

    2013-01-01

    The purpose of this study was to investigate the quality of Individualized Education Programs (IEPs) and its influence on academic achievement, inclusion in general education classrooms, and curricular access for students with disabilities. 130 teachers from the state of Indiana were asked to submit the most recent IEP of one of their students in…

  7. Topic Order in Introductory Physics and its Impact on the STEM Curricular Ladder

    Directory of Open Access Journals (Sweden)

    Teresa L Larkin

    2017-02-01

    Full Text Available Introductory physics courses are an important rung on the curricular ladder in STEM. These courses help to strengthen students critical thinking and problem solving skills while simultaneously introducing them to many topics they will explore in more detail in later courses in physics and engineering. For these reasons, introductory physics is a required element on the curricular ladder. Most often, introductory physics is offered as a two-semester sequence with basic mechanics being taught in the first semester and electricity and magnetism in the second. In fact, this curricular sequence has not been altered in decades. Is there a reason for this? There are many other enduring questions that arise pertaining to these foundation courses in physics. These questions include: Does taking the introductory course sequence “out of order” have an impact on student learning in physics? What topics should be taught? When should these topics be taught? What topics could be left out? The list of questions is essentially endless. This paper will address some of these questions in part, through a brief discussion on student learning in a second-semester algebra-based physics course. Connections will also be made to the broader curricular ladder in STEM. To this end, an illustration that makes connections to an engineering statics course will be presented. This discussion will conclude by presenting some broader implications for the larger STEM communities.

  8. Fostering Tolerance of Obesity through Empathy and Critical Reflection: A Curricular Unit Incorporating Filmed Testimonials

    Science.gov (United States)

    Ogle, Jennifer Paff; Damhorst, Mary Lynn

    2010-01-01

    With the prevalence of overweight and obesity on the rise in America, the role of educators in creating transformative learning contexts that minimize obesity bias and that foster tolerance has become increasingly crucial. The purpose of this work was to develop and explore the effectiveness of a curricular unit to promote tolerance and…

  9. From Curricular Justice to Educational Improvement: What Is the Role of Schools' Self-Evaluation?

    Science.gov (United States)

    Sampaio, Marta; Leite, Carlinda

    2017-01-01

    This article presents a study that aimed to understand the contributions of self-evaluation (SE) processes towards the development of curricular and social justice and educational improvement. The study focuses on data collected from the schools' external evaluation (SEE) process and from the TEIP programme (Educational Territories of Priority…

  10. Outsourcing Extra-Curricular Activities: A Management Strategy in a Time of Neoliberal Influence

    Science.gov (United States)

    Ng, Shun Wing; Chan, Tsan Ming Kenneth; Yuen, Wai Kwan Gail

    2017-01-01

    Purpose: The purpose of this paper is to report on an exploratory study designed to illuminate the complexity of outsourcing extra-curricular activities (ECAs) in primary schools in a time of neoliberal influence and to examine the views of teaching professionals on the reasons, issues and considerations of outsourcing ECAs such as the dynamic…

  11. New Curricular Material for Science Classes: How Do Students Evaluate It?

    Science.gov (United States)

    Freire, Sofia; Faria, Claudia; Galvao, Cecilia; Reis, Pedro

    2013-01-01

    Living in an unpredictable and ever changing society demands from its' citizens the development of complex competencies that challenges school, education and curriculum. PARSEL, a pan-European Project related to science education, emerges as a contribution to curricular development as it proposes a set of teaching-learning materials (modules) in…

  12. Curricular Implications of Virtual World Technology: A Review of Business Applications

    Science.gov (United States)

    Cyphert, Dale; Wurtz, M. Susan; Duclos, Leslie K.

    2013-01-01

    As business organizations grow increasingly virtual, traditional principles of organizational communication require examination and modification. This article considers the curricular implications of the growing business uses of virtual world technology through three different lenses--students as employee-users, students as strategic designers and…

  13. Discursos curriculares na disciplina escolar Química Curriculum discourses in school Chemistry

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    Alice Casimiro Lopes

    2005-08-01

    Full Text Available Neste artigo, é defendido que a disciplina escolar é um híbrido de discursos curriculares. Para argumentar em favor dessa idéia, é analisado como textos na área de ensino de Química influenciam nas políticas de currículo, hibridizando discursos oficiais e outros discursos curriculares. São articuladas as discussões teóricas de Ball, sobre políticas de currículo, de Goodson, sobre disciplinas escolares, de Bernstein, sobre recontextualização, e de Canclini, sobre hibridismo.This paper defends the hybridism of curricular discourses in school subjects. To argue in favor of this idea, chemistry education's texts are analyzed to show the influence of curriculum policy in hybridizing the official discourses and other curricular discourses. The text draws on the analysis of Ball about curriculum policy, on Goodson's school subjects, on Bernsteins's recontextualization and Canclini's hybridism.

  14. Typology of Extra-Curricular Activities and Academic Procrastination among Primary Education Students

    Science.gov (United States)

    Clariana, M.; Cladellas, R.; Gotzens, C.; Badia, M.; Dezcallar, T.

    2014-01-01

    Introduction: Some previous studies have shown that participation in extra-curricular activities optimises both academic grades and the socialisation process of students. However, nobody has so far related extracurricular activities with a tendency for academic procrastination; that is, the more or less deep-rooted habit of leaving study tasks…

  15. The Curricular Expectations and Practice of Caring among Girls and Boys in the USA and Turkey

    Science.gov (United States)

    Nowak-Fabrykowski, Krystyna; Dinçer, F. Çaglayan; Sen, Müge

    2016-01-01

    The goal of this research is to compare curricular expectations regarding caring behaviour in the USA and Turkey and to analyse the practical implication by investigating boys' and girls' caring behaviour. Conceptual framework of this research is underpinned in philosophical ideals of ethics of care and is grounded in theories stressing the…

  16. Held Back: The Impact of Curricular and Pedagogical Factors on Tested Achievement in High School Mathematics

    Science.gov (United States)

    Agvanian, Zara

    2013-01-01

    This study examined the impact of curricular factors and teaching practices on students' tested achievement in mathematics, explored the best predictors of the tested achievement, and examined differences in the tested achievement among student subgroups. The study utilized qualitative and quantitative methods and triangulated findings from…

  17. Comportamiento morfoagronómico de variedades de morera (Morus alba L. durante el establecimiento Morphoagronomic performance of mulberry (Morus alba L. varieties during the establishment

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    Gertrudis Pentón

    2007-09-01

    Full Text Available En áreas de la EEPF "Indio Hatuey" se realizó un estudio con el objetivo de evaluar el comportamiento morfoagronómico de cuatro variedades de morera (Morus alba L. (Criolla, Indonesia, Cubana y Tigreada, durante la etapa de establecimiento de plantas trasplantadas. El material vegetativo (posturas fue aviverado durante 120 días. La dinámica de emergencia de las yemas fue significativamente superior en las variedades Indonesia, Tigreada y Cubana con respecto a la Criolla. La variedad Tigreada alcanzó la mayor tasa promedio de desarrollo de nuevas ramas (0,25 ramas/día, aunque sin diferencias significativas respecto a las restantes variedades. La longitud de las ramas tendió a ser superior en la var. Tigreada (0,89 cm promedio por día, seguida por las variedades Indonesia, Cubana y Criolla (0,77; 0,73 y 0,63 cm/día, respectivamente. Sin embargo, el grosor de las ramas fue mayor en las variedades Cubana y Criolla. La variedad Indonesia se caracterizó por un significativo crecimiento en altura y grosor de la base del tallo principal (154 cm y 14,6 mm respecto al resto de las variedades. Todo ello tuvo una repercusión marcada en la producción de hojas, en lo cual se destacó la variedad Tigreada; le siguieron, aunque con diferencias significativas entre ellas, las variedades Indonesia, Cubana y Criolla. Se concluye que Tigreada e Indonesia resultaron ser las variedades de mejor comportamiento morfoagronómico durante el establecimiento; la primera se caracterizó por un alto potencial de producción de hojas y la segunda por una notable capacidad de acumulación de tejido leñoso.A study was carried out in areas of the EEPF "Indio Hatuey" in order to evaluate the morphoagronomic performance of four mulberry (Morus alba L. varieties (Criolla, Indonesia, Cubana and Tigreada, during the establishment stage of transplanted plants. The vegetative material (seedlings was placed in a nursery for 120 days. The bud emergence dynamics was

  18. Construcción politica de reformas curriculares: El caso de Chile en los noventa

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    Cristián Cox

    2006-01-01

    Full Text Available El autor es un experto implicado en el proceso de diseño curricular vivido en Chile desde la promulgación del LOCE en 1990. El artículo, Basándose en esta experiencia, el artículo describe con detalle este proceso. Muestra las claves, circunstancias y momentos del proceso de construcción y desarrollo de una reforma curricular. Da cuenta de los procesos y contextos que intervienen en ello. Señala que tiene un proceso de construcción política. Pero no sólo se deben a este tipo de decisiones (como marco ideológico y social de decisiones y poder. Los procesos reflexivos que acompañan la toma de decisiones y los cursos de acción generados son importantes. Como también lo es la historia. Incluso los lineamientos curriculares y las presiones hacia el cambio que se den globalmente pueden influir bastante. Así muestra como en Chile, a pesar de partir de una política educativa en la que no había entrado la idea de currículum, ésta empieza a emerger conforme se va construyendo su desarrollo práctico y curricular. De todas las lecciones aprendidas en el proceso destaca que son componentes clave del proceso la participación y la innovación. Argumenta que hay razones sustantivas y políticas para ello. La primera es clave para que el profesorado se apropie de la propuesta de reforma y la haga posible. Por último, destaca que se produce un desarrollo de las capacidades institucionales de diseño y desarrollo curricular en la medida que se ponen en marcha y acumulan procesos de este tipo.

  19. Research Concerning Morpho Characteristics of Romanian Yellow Spotted Breeded in Condition of S.C. Agrolact Farm, Alba County

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    claudiu eugen Jurco

    2013-05-01

    Full Text Available Researches regarding morpho characteristics of Romanian Yellow Spotted breed were performed on 70 cows bull daughters in testing and candidate cow bull mothers, raised and exploited in SC Agrolact SRL farm from Alba county and has as database, records of evaluation for reliability cows between 2004 -2009 from UARZ – Alba county. We can notice that the height at withers raises from 132.69 cm in first lactation to 136 cm in third lactation, and the height at rump shows an increase between the first and third lactation of 3.94 cm. The averages values of body measurements followed for the entire farm shows a number of animals of medium size (HW=136 cm; HR=139.58 cm with an average body weight of 647 kg wich suits the weight wanted limits desired for this breed (600-700 kg.

  20. HS-SPME AS AN EFFICIENT TOOL FOR DISCRIMINATING CHEMOTYPES OF Lippia alba (Mill. N. E. Brown

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    Aiêrta C. C. da Silva

    Full Text Available Lippia alba (Mill. N. E. Brown (Verbenaceae is a medicinal plant for which several biological activities are reported, such as sedative, anxiolytic, anti-ulcer, antifungal, antimicrobial, antioxidant, antispasmodic, anti-nociceptive and anti-inflammatory. It is characterized by the production of essential oils which have been used to classify the plant in different chemotypes. In the Northeast region of Brazil, the presence of three chemotypes are reported: myrcene-citral (chemotype I, limonene-citral (chemotype II and carvone-limonene (chemotype III. In this work, headspace-solid phase microextraction (HS-SPME was used on the analysis of the volatile organic compounds (VOCs of three chemotypes of L. alba from the Northeast region of Brazil, and compared to the essential oils of the plants extracted by hydrodistillation. Volatile compounds from each chemotype were more effectively differentiated when extracted by HS-SPME than by hydrodistillation.

  1. THE BIODIVERSITY OF THE MELLIFEROUS PLANTS IN THE SURROUNDINGS OF THE TOWN SEBES (ALBA COUNTY AND THEIR ECONOMICAL IMPORTANCE

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    Iuliana ANTONIE

    2014-12-01

    Full Text Available The goal of our research is to analyze the biodiversity of the melliferous plants in Alba County, mainly in the surroundings of Sebes by identifying the melliferous plants from the spontaneous flora and of the tree species without inflorescence. In the same time there were analyzed other aspects such as: the thermic index of the blooming (T, the average data of starting of the blooming, the honey production (kg/ha and the apiarian weight. The methods and the techniques that were used in the study were as follows: the use of the bibliographical resources, the observation, the use of the method of direct collecting, getting photos, and the determination of the botanic materials in the lab. There were identified 48 melliferous species from the spontaneous flora and 5 tree species without inflorescence (manna honey. In Alba County does regularly average productions on bee families, superior to those done in the country due to a valuable melliferous potential.

  2. Iron oxide impregnated Morus alba L. fruit peel for biosorption of Co(II): biosorption properties and mechanism.

    Science.gov (United States)

    Koduru, Janardhan Reddy; Chang, Yoon-Young; Yang, Jae-Kyu; Kim, Im-Soon

    2013-01-01

    Biosorption is an ecofriendly wastewater treatment technique with high efficiency and low operating cost involving simple process for the removal of heavy metal ions from aqueous solution. In the present investigation, Morus alba L. fruit peel powder (MAFP) and iron oxide impregnated Morus alba L. fruit peel powder (IO-MAFP) were prepared and used for treating Co(II) contaminated aqueous solutions. Further the materials were characterized by using FTIR and SEM-EDX analysis. From FT-IR analysis it was found that hydroxyl, methoxy, and carbonyl groups are responsible for Co(II) biosorption. The kinetic data obtained for both biosorbents was well fitted with pseudo-second-order kinetic model. The equilibrium data was in tune with the Langmuir and Freundlich isotherm models. The thermodynamic studies were also carried and it was observed that sorption process was endothermic at 298-328 K. These studies demonstrated that both biosorbents were promising, efficient, economic, and biodegradable sorbents.

  3. Vestigios de Alvar Aalto en la opera prima de Antonio Fernández Alba (1959-62

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    Lucía C. Pérez-Moreno

    2018-04-01

    Full Text Available La obra de Antonio Fernández Alba de los años sesenta ha sido fundamentalmente calificada de orgánica aludiendo a sus consonancias con la arquitectura de Alvar Aalto. Este texto ahonda en la lectura que Fernández Alba presentó sobre la cultura finesa en varios escritos publicados en la revista madrileña Arquitectura, entre los que destaca el ensayo “Valores humanos y estéticos en el diseño finlandés” publicado en 1962. Reflexiones presentadas en este texto tomaron forma en el colegio Nuestra Señora Santa María en Madrid, un proyecto en el que Fernández Alba estaba trabajando en estos mismos años. Sin eludir la condición de colegio católico y femenino del proyecto, se reflexiona en torno a decisiones proyectuales que ponen de manifestó el interés de Fernández Alba por ofrecer a las niñas educadas en sus espacios una arquitectura propicia para el juego, conectada con la naturaleza circundante, no regida por formas preconcebidas, amable en la elección de sus materiales y libre en el uso y disfrute de sus dependencias. En definitiva, una arquitectura que tuvo en cuenta las necesidades psicofísicas de alumnas y profesorado o una arquitectura humanizada, aludiendo al conocido ensayo de Alvar Aalto escrito en 1940.

  4. Effect of Lippia alba and Cymbopogon citratus essential oils on biofilms of Streptococcus mutans and cytotoxicity in CHO cells.

    Science.gov (United States)

    Tofiño-Rivera, A; Ortega-Cuadros, M; Galvis-Pareja, D; Jiménez-Rios, H; Merini, L J; Martínez-Pabón, M C

    2016-12-24

    Caries is a public health problem, given that it prevails in 60 to 90% of the school-age global population. Multiple factors interact in its etiology, among them dental plaque is necessary to have lactic acid producing microorganisms like Streptococcus from he Mutans group. Existing prevention and treatment measures are not totally effective and generate adverse effects, which is why it is necessary to search for complementary strategies for their management. The study sought to evaluate the eradication capacity of Streptococcus mutans biofilms and the toxicity on eukaryotic cells of Lippia alba and Cymbopogon citratus essential oils. Essential oils were extracted from plant material through steam distillation and then its chemical composition was determined. The MBEC-high-throughput (MBEC-HTP) (Innovotech, Edmonton, Alberta, Canada) assay used to determine the eradication concentration of S. mutans ATCC 35668 strain biofilms. Cytotoxicity was evaluated on CHO cells through the MTT cell proliferation assay. The major components in both oils were Geraniol and Citral; in L. alba 18.9% and 15.9%, respectively, and in C. citratus 31.3% and 26.7%. The L. alba essential oils presented eradication activity against S. mutans biofilms of 95.8% in 0.01mg/dL concentration and C. citratus essential oils showed said eradication activity of 95.4% at 0.1, 0.01mg/dL concentrations and of 93.1% in the 0.001mg/dL concentration; none of the concentrations of both essential oils showed toxicity on CHO cells during 24h. The L. alba and C. citratus essential oils showed eradication activity against S. mutans biofilms and null cytotoxicity, evidencing the need to conduct further studies that can identify their active components and in order to guide a safe use in treating and preventing dental caries. Copyright © 2016 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

  5. New Microsatellite Loci for Prosopis alba and P. chilensis (Fabaceae)

    OpenAIRE

    Cecilia F. Bessega; Carolina L. Pometti; Joe T. Miller; Richard Watts; Beatriz O. Saidman; Juan C. Vilardi

    2013-01-01

    Premise of the study: As only six useful microsatellite loci that exhibit broad cross-amplification are so far available for Prosopis species, it is necessary to develop a larger number of codominant markers for population genetic studies. Simple sequence repeat (SSR) markers obtained for Prosopis species from a 454 pyrosequencing run were optimized and characterized for studies in P. alba and P. chilensis. Methods and Results: Twelve markers that were successfully amplified showed polymo...

  6. CARACTERIZAÇÃO QUÍMICA E ATIVIDADE MUTAGÊNICA DO ÓLEO ESSENCIAL DE Lippia alba

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    Thammyres de Assis Alves

    2017-01-01

    Full Text Available Os óleos essenciais são substâncias voláteis que vêm despertando interesse no setor agrícola, devido o grande potencial que possuem no controle de pragas. Assim, objetivo deste trabalho foi determinar a composição química do óleo essencial de folhas de Lippia alba e avaliar o seu potencial mutagênico. Para isso, o óleo essencial foi obtido por hidrodestilação, utilizando um aparelho do tipo Clevenger, seus constituintes químicos foram analisados por meio da cromatografia em fase gasosa com detector de ionização de chama (CG-DIC e de espectrometria de massas (CG-EM. Os compostos majoritários encontrados foram: geranial (29,83%, neral (20,71% e óxido de cariofileno (19,26%. A toxicidade do óleo essencial de L. alba foi avaliado em sementes de Lactuca sativa. O óleo essencial de L. alba inibiu 100% o crescimento radicular das sementes de L. sativa nas concentrações de 0,720% e 0,360% (m v-1. Nas outras concentrações testadas (0,180%, 0,090%, 0,045%, o óleo essencial apresentou um decréscimo no efeito de inibição conforme diminuição de sua concentração. Logo, o óleo essencial de L. alba possui potencial a ser usado como bioherbicida.

  7. REGIONAL VARIATION IN THE MICROSCOPY AND TENSILE STRENGTH OF THE LINEA ALBA IN THE BABOON (PAPIO ANUBIS. Variación regional de la microscópia y resistencia a la tracción de la línea alba del babuino (Papio Anubis.

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    Paul Odula

    2016-11-01

    Full Text Available Introducción: La línea alba conecta el rectus abdominis, y por lo tanto su debilitamiento o el aumento de la tension intra-abdominal puede resultar en una diastasis rectal. El objetivo de este estudio es investigar la morfología funcional y la resistencia a la tracción de la línea alba en un primate no humano. Materiales y métodos: Utilizando como puntos de referencia el xifoides, el ombligo y el tubérculo púbico, fueron resecados tejidos de la zonas epigástrica, umbilical e hipogástrica de la línea alba de siete babuinos machos. Estos tejidos se procesaron a través del microscopio y tensiometría. Resultados: La línea alba se compone principalmente de fibras de colágeno organizadas en tres láminas, a saber, superficiales, intermedias y profundas, además de algunas fibras elásticas. La lámina intermedia de la línea alba umbilical se caracterizó por estar formada de grupos compactos y gruesos de colágeno alineados longitudinalmente y oblicuamente que se fusionan en el centro y forman una masa. La fuerza máxima para romper la línea alba durante una tracción longitudinal y oblicua fue de 40 N/mm2 y 63.6 N/mm2 con una tensión de 0.35 y 1.19 respectivamente. El módulo de Young de la línea alba mostró que, la línea alba epigástrica y umbilical tuvo el mayor coeficiente de elasticidad media, de 289 N/mm2 y 328 N/mm2, respectivamente, cuando fueron expuestos a una tracción oblicua. Conclusión: La estructura de la línea alba del babuino está diseñada para soportar grandes tensiones o fuerzas multidireccionales.Introduction: The linea alba connects the rectus abdominis and thus weakening or increased abdominal pressure may result in diastasis recti. The study aims to investigate the functional morphology and the tensile strength of the linea alba in a non-human primate. Materials and Methods: Using the xiphoid process, the umbilicus, and the pubic tubercle as landmarks, tissues were resected from the

  8. Assessment of the repellent effect of Lippia alba essential oil and major monoterpenes on the cattle tick Rhipicephalus microplus.

    Science.gov (United States)

    Lima, A da Silva; Carvalho, J F de; Peixoto, M G; Blank, A F; Borges, L M F; Costa Junior, L M

    2016-03-01

    The control of Rhipicephalus microplus (Ixodida: Ixodidae) is achieved using synthetic acaricides. However, resistant tick populations are widespread around the world. Plant essential oils can act as repellents, keeping ticks away from hosts and decreasing the selection pressure on synthetic acaricides. The aim of this study was to evaluate the in vitro repellent effect of Lippia alba essential oil on R. microplus larvae. Leaves from two L. alba genotypes maintained under the same agronomic and environmental conditions were collected. Essential oil was extracted by hydrodistillation and analysed by gas chromatography-mass spectrometry (GC-MS). The major monoterpenes detected in the chemical analysis were commercially acquired and tested. For the repellency test, a glass rod was vertically fixed to measure active climbing of approximately 30 R. microplus larvae aged 14-21 days in response to essential oils and monoterpenes. Repellency was evaluated at 1 h, 3 h and 5 h after treatment. Variation in repellent action was detected between the genotypes. The major monoterpenes identified in the essential oils (limonene and carvone) showed low repellent effects in comparison with intact essential oils. Thus, the present results showed that L. alba essential oil contains bioactive compounds with great repellent activity against ticks that varies according to the plant genotype. © 2015 The Royal Entomological Society.

  9. Antimutagenic evaluation of traditional medicinal plants from South America Peumus boldus and Cryptocarya alba using Drosophila melanogaster.

    Science.gov (United States)

    Carmona, Erico R; Reyes-Díaz, Marjorie; Parodi, Jorge; Inostroza-Blancheteau, Claudio

    2017-01-01

    Peumus boldus Mol. ("Boldo") and Cryptocarya alba Mol. Looser ("Peumo") are medicinal shrubs with wide geographical distribution in South America. Their leaves and fruits are commonly used in traditional medicine because they exhibit natural medicinal properties for treatment of liver disorders and rheumatism. However, there are no apparent data regarding potential protective effects on cellular genetic components. In order to examine potential mutagenic and/or antimutagenic effects of these medicinal plants, the Drosophila melanogaster (D. melanogaster) wing-spot test was employed. This assay detects a wide range of mutational events, including point mutations, deletions, certain types of chromosomal aberrations (nondisjunction), and mitotic recombination. Qualitative and quantitative analyses of phenolic and anthocyanin compounds were carried out using biochemical and high-performance liquid chromatography methodologies. In addition, the antioxidant capacity of P. boldus and C. alba leaf extracts was also analyzed. P. boldus and C. alba extracts did not induce significant mutagenic effects in the D. melanogaster model. However, simultaneous treatment of extracts concurrently with the mutagen ethyl methane sulphonate showed a decrease of mutant spots in somatic cells of D. melanogaster, indicating desmutagenic effects in this in vivo model. Flavonoids and anthocyanins were detected predominantly in the extracts, and these compounds exerted significant antioxidant capacity. The observed antimutagenic effects may be related to the presence of phytochemicals with high antioxidant capacity, such as flavonoids and antohocyanins, in the extracts.

  10. The potential role of Morus alba leaves extract on the brain of mice infected with Schistosoma mansoni.

    Science.gov (United States)

    Bauomy, Amira A

    2014-01-01

    Schistosomiasis is a neglected tropical disease which is associated with neuropsychiatric and neuropathological disorders. Herein, the main goal of the presented work is to investigate the effect of Morus alba leaves extract in mice brain infected with Schistosoma mansoni. Since, the resistance of Schistosomes to antischistosomal drug (praziquantel) has been examined, schistosomiasis induced brain oxidative stress as evidenced by the decrease of glutathione level, total antioxidant capacity and the activity of catalase significantly, while a significant elevation in the levels of nitrite/nitrate and malondialdhyde. In addition, the infection resulted in neurochemical disturbances, the main inhibitory amino acid, γ- aminobutyric acid level was decreased. In contrast, the level of chloride ions and acetylcholine esterase activity were significantly increased. Moreover, the histopathological section showed some impairments in the brain. The treatment with Morus alba leaves extract ameliorated the induced disturbances in schistosome-infected mice where the levels of non-enzymatic and enzymatic antioxidants were elevated. On the other hand, the levels of nitrite/nitrate and malondialdhyde were significantly reduced. Likewise, treatment of mice with Morus alba leaves extract improved the altered levels of γ- aminobutyric acid level and chloride ion. Also, it improved the recorded impairments of the histopathological section in the brain of schistosome infected mice.

  11. Effects of auricular acupressure using Sinapsis alba seeds on obesity and self-efficacy in female college students.

    Science.gov (United States)

    Kim, Dongwon; Ham, Ok Kyung; Kang, Changwan; Jun, Eunmi

    2014-04-01

    To examine the effects of auricular acupressure with Sinapsis alba seeds on obesity and self-efficacy. Randomized controlled trial. College settings located in metropolitan areas of Korea. A total of 49 female college students who were overweight or obese (body-mass index [BMI] ≥25.0 kg/m(2)) were recruited and randomly assigned to the experimental group (n=25) or the control group (n=24). The experimental group applied three S. alba seeds to each of five auricular points (Shenmen, mouth, stomach, endocrine, and small intestine points). These participants were asked to stimulate those points 10 times at a rate of two times per second 30 minutes before mealtime, three times daily, for 1 month. They performed the procedure for each earlobe for alternating weeks (a total of 2 weeks' treatment for each ear). The obesity index included weight (kg), BMI (kg/m(2)), percentage body fat, and waist-to-hip ratio. Self-efficacy was measured by using a self-efficacy scale. Female students in the experimental group showed significant decreases in weight (t=10.76; p0.05) and waist-to-hip ratio (t=0.60; p>0.05) changes did not significantly differ between the two groups. These findings suggest that auricular acupressure using S. alba seeds may be an effective intervention for decreasing weight and BMI and increasing self-efficacy of overweight and obese individuals.

  12. HMG-CoA reductase inhibitory activity and phytocomponent investigation of Basella alba leaf extract as a treatment for hypercholesterolemia

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    Baskaran G

    2015-01-01

    Full Text Available Gunasekaran Baskaran,1 Shamala Salvamani,1 Siti Aqlima Ahmad,1 Noor Azmi Shaharuddin,1 Parveen Devi Pattiram,2 Mohd Yunus Shukor1 1Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, 2Department of Food Technology, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia Abstract: The enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA reductase is the key enzyme of the mevalonate pathway that produces cholesterol. Inhibition of HMG-CoA reductase reduces cholesterol biosynthesis in the liver. Synthetic drugs, statins, are commonly used for the treatment of hypercholesterolemia. Due to the side effects of statins, natural HMG-CoA reductase inhibitors of plant origin are needed. In this study, 25 medicinal plant methanol extracts were screened for anti-HMG-CoA reductase activity. Basella alba leaf extract showed the highest inhibitory effect at about 74%. Thus, B. alba was examined in order to investigate its phytochemical components. Gas chromatography with tandem mass spectrometry and reversed phase high-performance liquid chromatography analysis revealed the presence of phenol 2,6-bis(1,1-dimethylethyl, 1-heptatriacotanol, oleic acid, eicosyl ester, naringin, apigenin, luteolin, ascorbic acid, and a-tocopherol, which have been reported to possess antihypercholesterolemic effects. Further investigation of in vivo models should be performed in order to confirm its potential as an alternative treatment for hypercholesterolemia and related cardiovascular diseases. Keywords: HMG-CoA reductase, Basella alba, phytochemical, GC-MS/MS, RP-HPLC, hypercholesterolemia

  13. Effects of Pleistocene sea-level fluctuations on mangrove population dynamics: a lesson from Sonneratia alba.

    Science.gov (United States)

    Yang, Yuchen; Li, Jianfang; Yang, Shuhuan; Li, Xinnian; Fang, Lu; Zhong, Cairong; Duke, Norman C; Zhou, Renchao; Shi, Suhua

    2017-01-18

    A large-scale systematical investigation of the influence of Pleistocene climate oscillation on mangrove population dynamics could enrich our knowledge about the evolutionary history during times of historical climate change, which in turn may provide important information for their conservation. In this study, phylogeography of a mangrove tree Sonneratia alba was studied by sequencing three chloroplast fragments and seven nuclear genes. A low level of genetic diversity at the population level was detected across its range, especially at the range margins, which was mainly attributed to the steep sea-level drop and associated climate fluctuations during the Pleistocene glacial periods. Extremely small effective population size (Ne) was inferred in populations from both eastern and western Malay Peninsula (44 and 396, respectively), mirroring the fragility of mangrove plants and their paucity of robustness against future climate perturbations and human activity. Two major genetic lineages of high divergence were identified in the two mangrove biodiversity centres: the Indo-Malesia and Australasia regions. The estimated splitting time between these two lineages was 3.153 million year ago (MYA), suggesting a role for pre-Pleistocene events in shaping the major diversity patterns of mangrove species. Within the Indo-Malesia region, a subdivision was implicated between the South China Sea (SCS) and the remaining area with a divergence time of 1.874 MYA, corresponding to glacial vicariance when the emerged Sunda Shelf halted genetic exchange between the western and eastern coasts of the Malay Peninsula during Pleistocene sea-level drops. Notably, genetic admixture was observed in populations at the boundary regions, especially in the two populations near the Malacca Strait, indicating secondary contact between divergent lineages during interglacial periods. These interregional genetic exchanges provided ample opportunity for the re-use of standing genetic variation

  14. Las formas verbales en las biblias de Alba y Ferrara: ¿fidelidad al texto hebreo?

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    del Barco del Barco, Francisco Javier

    2004-12-01

    Full Text Available This article focuses on the study of narrative and prophetic texts in the Ferrara and Alba Bibles and on their comparison to the Hebrew original. The aim of such a study is to find the keys to their systems of translation within the medieval Jewish tradition of Biblical translations. One of the most remarkable aspects is the translation of the verbal forms from Biblical Hebrew to Spanish. What is interesting about this aspect is how the translators understand the verbal system of Biblical Hebrew and how they converted it into 15th and 16th century Castillan, as well as the existing differences in the translation of both bibles; this fact will be illustrated with abundant examples. The linguistic aspect is offered here in its sociological and cultural context, as factors that affect translation methods.

    Este artículo se centra en el estudio de textos narrativos y proféticos de las biblias de Alba y Ferrara y en su comparación con el original hebreo. El fin de tal estudio es hallar las claves de sus sistemas de traducción dentro de la tradición judía medieval de traducciones bíblicas. Uno de los aspectos más destacables es la traducción de las formas verbales del hebreo bíblico al español. El interés en este punto está en ver cómo los traductores entienden el sistema verbal del hebreo bíblico y lo vierten al castellano de los ss. XV y XVI, así como en las diferencias de traducción existentes entre ambas biblias, que será ilustrado con numerosos ejemplos. El aspecto lingüístico se presenta aquí en su contexto sociológico y cultural, como factores que influyen en los métodos de traducción.

  15. Recent and subrecent diet of the barn owl (Tyto alba in Slovakia

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    Obuch Ján

    2016-12-01

    Full Text Available We completed data on the diet of the barn owl (Tyto alba predominately from pellets for the period of the last 50 years from Slovakia. We analyzed material from 251 locations and 16 territorial units. The aggregate represents 119,231 pieces of prey from 47 species of mammals (Mammalia, 95.7% and 58 species of birds (Aves, 3.9%, with a small representation of amphibians, reptiles (Amphibia and Reptilia, 0.2% and invertebrates (Invertebrata, 0.2%. The obtaining of food among the owls is limited to synanthropic environments and the surrounding agricultural landscape, and the centre of its distribution in the recent period (i.e. the past 50 years: 1965-201 5 has been concentrated mainly on the southern parts of Slovakia. In this environment the common vole (Microtus arvalis, 59.6% is the primary prey. Additional prey are rodents of the family Muridae: Mus musculus (5.6%, Micromys minutus (2.2%, Apodemus microps (2.2%, A. flavicollis (2.0%, A. sylvaticus (1 .6% and A. agrarius (1 .5%; insectivores of the family Soricidae: Sorex araneus (6.2%, S. minutus (2.4%, Crocidura leucodon (4.8% and C. suaveolens (2.8%; and the house sparrow Passer domesticus (2.9%. In the higher situated Turcianska kotlina Basin the species M. arvalis (74.3% has higher domination, and instead of the white-toothed shrews the water shrews Neomys anomalus (2.8% and N. fodiens (1 .3% are more abundantly represented. In 3 localities owls focused on hunting bats; for example, in the church in Ratková the order Chiroptera made up 35.2% of prey. From the subrecent period (i.e. from before more than 50 years ago we evaluate 4 samples from the territory of Slovakia with 15,601 pieces of prey ofT. alba. Before more than 50 years ago owls were also more abundantly represented at higher elevations in Slovakia, evidence of which is Weisz’s collection of pellets from 1 6 localities in the Ondavská vrchovina Upland in the years 1945 to 1963, but also a registry of data from the 19th and

  16. A Botanical Composition from Morus alba, Ilex paraguariensis, and Rosmarinus officinalis for Body Weight Management.

    Science.gov (United States)

    Yimam, Mesfin; Jiao, Ping; Hong, Mei; Brownell, Lidia; Lee, Young-Chul; Kim, Hyun-Jin; Nam, Jeong-Bum; Kim, Mi-Ran; Jia, Qi

    2017-11-01

    Obesity is the largest and fastest growing public health catastrophe in the world affecting both adults and children with a prevalence impacting more than one-third of United States (US) adult population. Although the long-term solution lies in lifestyle changes in the form of dieting and exercise, intervention is required for those who are already obese. Unfortunately, treatment options remain quite limited due to associated side effects of conventional therapeutics. As a natural alternative, in this study we describe the beneficial effect of a standardized composition (UP603) comprised of extracts from Morus alba, Ilex paraguariensis, and Rosmarinus officinalis in improving metabolic disorders in high fat diet (HFD) and high fat & high fructose diet (HFFD) induced obese C57BL/6J mice. Mice treated with UP603 showed dose-correlated decrease in body weight gains compared to vehicle treated HFFD group. Following 7 weeks of treatment, the changes in body weight gains from baseline were found as 6.4%, 27.3%, 2.0%, 3.1%, 0.4%, and -2.9% for normal control diet, HFFD, Orlistat, 450, 650, and 850 mg/kg UP603 treated animals, respectively. Reductions of 7.9-21.1% in total cholesterol, 25.4-44.6% in triglyceride, and 22.5-38.2% in low-density lipoprotein were observed for mice treated with 450-850 mg/kg of UP603. In a dual energy X-ray absorptiometry scan, percentage body fat of 18.9%, 47.8%, 46.1%, and 40.4% were found for mice treated with normal control, HFD, Orlistat, and UP603, respectively. Reductions of 65.5% and 16.4% in insulin and leptin, respectively, and 2.1-fold increase in ghrelin level were also observed for the UP603 group. Statistically significant improvements in nonalcoholic steatohepatitis scores were also observed from liver histology for mice treated with UP603. Hence, UP603, a standardized botanical composition from M. alba, I. paraguariensis, and R. officinalis could potentially be considered as a natural alternative to maintain healthy body

  17. Resultados preliminares del forraje de Morus alba en la alimentación de vacas lecheras

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    M. Milera

    2007-01-01

    Full Text Available El objetivo del presente trabajo consistió en evaluar el potencial del forraje de M. alba con vacas mestizas para la producción de leche. El trabajo se desarrolló en Cuba, la cual se encuentra localizada entre los 19° y 81’ de longitud oeste. La Estación Experimental de Pastos y Forrajes “Indio Hatuey” está ubicada en el municipio de Perico, provincia de Matanzas, sobre un suelo ferralítico rojo, a los 22° 40’ 7’’ de latitud norte y 81° 2’ de longitud oeste, a una altura de 10.91 msnm. La evaluación se hizo con vacas mestizas del cruce Holstein x Cebú, que tenían 54 días de lactancia. El estudio se dividió en dos periodos: en el primero (que duró 53 días se suministró el forraje de morera ad libitum, sin trocear, y se pastoreó de forma restringida en gramíneas mejoradas de secano, sin fertilización; en el segundo periodo, los animales dispusieron de pastoreo de gramíneas mejoradas con un 10% de un área establecida con Leucaena leucocephala y recibieron forraje de morera restringido hasta el 1% del peso vivo; éste tuvo una duración de 87 días. Se determinó la disponibilidad de pasto, la composición bromatológica y el consumo de forraje de Morus alba, así como la producción de leche de las vacas. El forraje de morera presentó altos va- lores de proteína y bajos contenidos de fibra; los consumos en el primer periodo llegaron hasta 2.7% del peso vivo. La producción de leche promedio fue de 10.6 kg/vaca/día durante los 140 días de evaluación y la máxima producción se registró en los primeros 53 días (1 kg/vaca/día. Los resultados demostraron la alta calidad de la morera cuando se utiliza como forraje para la alimentación de vacas mestizas. En las condiciones evaluadas, es posible obtener producciones de 10 litros por animal diariamente, cuando se utiliza el forraje de morera en adición al pasto de especies mejoradas, sin suplementación de concentrados.

  18. Wide Ranging Insect Infestation of the Pioneer Mangrove Sonneratia alba by Two Insect Species along the Kenyan Coast.

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    Elisha Mrabu Jenoh

    Full Text Available Insect infestation of mangroves currently threatens mangrove forest health and management. In the Western Indian Ocean region, little is known about insect damage to mangroves despite the fact that numerous infestations have occurred. In Kenya, infestations of Sonneratia alba have persisted for almost two decades, yet the taxonomic identity of the infesting pest(s, the extent of infestation, the pests' biology, the impacts of infestation on host and the ecosystem, the host's defensive strategies to the infestation are poorly understood. S. alba is a ubiquitous, pioneer mangrove species of the Indo-Pacific, occurring along the waterfront in a variety of mangrove ecosystem settings. Our main objectives were to identify the pest(s responsible for the current dieback of S. alba in Kenya, and to determine the extent of infestation. To identify the pests responsible for infestation, we trapped emergent insects and reared larvae in the laboratory. To determine the overall extent of infestation within the S. alba zone, we assessed nine sites along the entire Kenyan coastline for the presence or absence of infested mangroves. Insect infestation in two mangrove embayments (Gazi and Mida was quantified in depth. Two wood-boring insects were identified: a metarbelid moth (Lepidoptera, Cossoidea of undescribed genus and the beetle Bottegia rubra (Cerambycidae, Lamiinae.The metarbelid moth infests mangroves in both northern (from Ngomeni to Kiunga and southern regions (from Vanga to Mtwapa of the Kenyan coast. B. rubra appeared in low density in Gazi, and in high density in Mida, Kilifi, and Ngomeni, with densities gradually decreasing northward. Insect infestation levels reached 18% in Gazi and 25% of S. alba stands in Mida. Our results indicate that B. rubra has the ability to infest young mangrove trees and expand its range, posing a danger to rehabilitation efforts where plantations have been established. Thus, there is great need for forest managers to

  19. Formación de recursos humanos para el ALBA a partir de la investigación de discapacidad

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    Miriam Portuondo-Sao

    2016-05-01

    Full Text Available Objetivo: Caracterizar el universo de personas con discapacidades en países del ALBA y la intervención realizada para mejorar la atención de las mismas. Método:Fueron integrados los métodos epidemiológico, clínico-genético y psicopedagógico para el estudio del total de personas con discapacidad, empleando la investigación-acción participativa diseñada por Cuba en Venezuela, Ecuador, Nicaragua, Bolivia y San Vicente y las Granadinas. Resultados: Se generalizó una metodología cubana para el estudio de la discapacidad, en países del ALBA, donde se encontró una prevalencia entre el uno y el 3,3%, con más de un millón 247 mil personas con discapacidad investigadas, se ofrecieron un millón 800 mil consultas de especialidades carentes en el ALBA, entre las que se destacan 230 mil de genética clínica. Se identificó la necesidad de formar recursos humanos en especialidades deficitarias para la atención de la discapacidad. Conclusiones: La investigación permitió el desarrollo de políticas públicas y Programas de Atención y Prevención de la discapacidad, en respuesta a las necesidades identificadas en cada país, que hoy muestra significativos aportes como la inauguración del Centro Nacional de Genética Médica en Venezuela y la formación de 215 especialistas en el campo de la genética y la rehabilitación, a partir de graduados en la ELAM fundamentalmente; gracias a la integración de países del ALBA. Palabras clave: formación de recursos humanos; discapacidad; integración del ALBA; epidemiologia; investigación-acción.

  20. Diretrizes curriculares para o curso de pedagogia: trajetória longa e inconclusa Curricular guindelines for the pedagogy course: long and unfinished trajectory

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    Leda Scheibe

    2007-04-01

    Full Text Available Este artigo aborda as discussões e embates acerca da definição das diretrizes curriculares para o Curso de Pedagogia, ocorridos após a aprovação da Lei de Diretrizes e Bases da Educação Nacional de 1996. Focaliza o processo de mobilização e resistência das entidades do campo educacional no sentido de assegurar a docência como base para esse curso e a superação da dicotomia entre licenciatura e bacharelado no seu interior. A análise aponta como cerne do embate a contraposição ao modelo de formação dos Institutos Superiores de Educação e de Cursos Normais Superiores, veiculado pela reforma educacional da década de 1990, o qual se insere em um contexto de políticas neoliberais. Indica ainda que a recente aprovação de diretrizes curriculares para o Curso de Pedagogia (Parecer CNE/CP 5/2005 e Resolução CNE/CP 1/2006 e sua definição como uma licenciatura que forma unificadamente o professor para a educação infantil e anos iniciais do ensino fundamental, constitui uma solução negociada entre as entidades e o Conselho Nacional de Educação.This article addresses the discussions about the definition of curricular guidelines for the Pedagogy Course, as well as the oppositions to them, which occurred after the passage of the National Educational Guidelines and Framework Law of 1996. It focuses the process of mobilization and resistance of the institutions in the educational area in order to ensure teaching as the basis for this course and the overcoming of the dichotomy between teacher certification (licenciatura and bachelor degree in its interior. The analysis indicates that the central issue is the opposition to the education model of Higher Education Institutes and Higher Basic Education Teacher Education Programs, created by the education reform in the 1990s, which is inserted in a context of neoliberal policies. It also shows that the recent passage of the curricular guidelines for the Pedagogy Course (Official

  1. Estrategia curricular para la formación pedagógica en la carrera de Medicina Curricular strategy for the pedagogical training in Medicine course

    OpenAIRE

    Cecilia Valdés de la Rosa; Hilda Elena Iglesias Carnot; Mayda Duran Matos; Aurea Gayol Irizar; Mercedes Hernández González

    2010-01-01

    El Médico General Básico egresado debe poseer una cultura pedagógica que le proporcione las herramientas para desempeñar la función docente contemplada en su perfil profesional. El siguiente trabajo presenta una estrategia curricular para desarrollar la formación pedagógica de los estudiantes de Medicina. Las acciones propuestas están dirigidas en dos vertientes: una para el desarrollo de la labor educativa con el individuo, la familia y la comunidad, y la otra encaminada a la función docente...

  2. A importância do conhecimento escolar em propostas curriculares alternativas The importance of school knowledge for alternative curricular proposals

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    Antonio Flavio Barbosa Moreira

    2007-06-01

    Full Text Available O artigo focaliza um processo de construção curricular em uma escola da rede municipal de Belo Horizonte, no qual vigora a proposta oficial da ESCOLA PLURAL. Destaca as dificuldades vividas pelo corpo docente da escola e desenvolve o argumento de que propostas curriculares inovadoras podem criar um espaço discursivo no qual se segregam as crianças das camadas populares, reduzindo suas possibilidades de autonomia na sociedade. Com base nas concepções de política de Stephen Ball e Jenny Ozga, analisam-se os textos políticos da Escola Plural e de uma escola da rede municipal. Verificou-se a complexa relação entre documentos oficiais e experiências locais, bem como a necessidade de se afirmar a importância do conhecimento escolar no currículo. Argumenta-se que a supervalorização do aluno e de suas experiências culturais, em associação com a secundarização do conhecimento escolar, pode criar um espaço em que a criança seja confinada e jamais vista como normal.The paper focuses on a process of curriculum construction which was developed in a school from the Belo Horizonte educational system. The school is organized according to the official curricular proposal entitled PLURAL SCHOOL. It emphasizes the difficulties which were faced by the academic staff of the school and argues that innovative curricular proposals may create a space in which children from working class are segregated and have their possibilities of autonomy in society reduced. Drawing on the conceptions of politics by Stephen Ball and Jenny Ozga, the political texts, written on the level of the Plural School proposal and on the level of the school, are analyzed. The complex relations among official documents and local experiences are emphasized. The importance of school knowledge is stressed. It is argued that the overvaluation of the students and their cultural experiences and the undervaluation of school knowledge can create a space in which children are

  3. La configuración curricular desde la atención a la diversidad en el proceso formativo universitario Curricular shaping within the university formative process. An approach to the attention paid to diversity

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    Enrique Loret de Mola López

    2012-12-01

    Full Text Available La configuración curricular desde la atención a la diversidad en el proceso formativo universitario, resultará de la interacción de los planos cognitivo-actitudinal y procedimental. La suficiencia, recursividad y coherencia curricular son sustentos que lo convierten de proyecto predelineado a propuesta emergente en la que se planifica como un espacio de permanente construcción y reconstrucción en el que se interconectan el conocimiento conceptual, las experiencias y los sentimientos de los estudiantes. El artículo tiene como objetivo socializar los resultados alcanzados en la sistematización de una concepción teórica para el desarrollo de los procesos curriculares, a partir del planteamiento de algunas ideas que lo relacionan con lo diverso que resulta el mundo universitario y que pueden constituir punto de partida para el debate sobre el diseño curricular.Curricular shaping in regard on the attention to the diversity of the university formative process will be result of the interaction of the different cognitive-attitudinal, and procedural planes. Aptitude, resourcefullness and curricular coherence are the bases that allow this preformulated project to become an emerging proposal, which is seen as a space of permanent construction and reconstruction, experiences and students´ feelings. This article aims at socializing the results obtained in the systematization process of a theoretical conception for the development of curricular processes; based on the approach of several ideas that relate it with the diversity of university sphere, and these ideas may also represent a starting point for debate about curricular design.

  4. Crecimiento de Morus alba L. durante la etapa de establecimiento, a partir del trasplante de posturas Growth of Morus alba L. during the establishment stage, since seedling transplant

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    Gertrudis Pentón

    2012-06-01

    Full Text Available El objetivo de este estudio fue evaluar el comportamiento morfoagronómico de la especie Morus alba L. var.Tigreada durante la primera etapa de establecimiento, a partir del trasplante de posturas. Para ello, se determinó la respuesta del cultivo al manejo de estas para el trasplante, se caracterizó el crecimiento y se determinaron las variables lineales que permiten cuantificar el área foliar de dicha variedad. Las posturas se mantuvieron en el vivero durante 120 días y se trasplantaron en el período lluvioso. Los surcos se orientaron de este a oeste, con un marco de siembra de 1,0 x 0,5 m. Se mantuvo un adecuado control de las malezas, las plagas y las enfermedades. No se regó y se aplicó materia orgánica en el momento del trasplante. Se establecieron dos formas de manejo de las posturas para el trasplante: deshoje total, y corte a la altura de 50 cm y deshoje total. Durante la etapa inicial de crecimiento posterior al trasplante, se obtuvo un ligero aumento en la capacidad de rebrote de las posturas cortadas y deshojadas. Ello no afectó el establecimiento de la especie, pues a los 135 días la producción de biomasa foliar varió entre 100 y 116 g/planta. El crecimiento en los primeros 155 días describió una curva sigmoidea, caracterizada por un ritmo lento durante los primeros 21 días; a ello le siguió un crecimiento intenso entre los 30 y 135 días, el cual se tornó nuevamente lento con el inicio de la época seca o invernal. Se demostró que la medición del largo de la hoja y su ajuste a través de los modelos no lineales Y = B0+B1X+B2X2 y Y = B0+B1X+B2X2+B3X3 permiten estimar el área foliar, y ello se cumple para la condición de que el largo del óvalo foliar mida entre 1,3 y 20,4 cm. La alta correlación encontrada hace apropiado este procedimiento de estimación.The objective of this study was to evaluate the morphoagronomic performance of the specie Morus alba L. var. Tigreada during the first establishment stage

  5. HPLC-Based Method to Evaluate Kinetics of Glucosinolate Hydrolysis by Sinapis alba Myrosinase1

    Science.gov (United States)

    Vastenhout, Kayla J.; Tornberg, Ruthellen H.; Johnson, Amanda L.; Amolins, Michael W.; Mays, Jared R.

    2014-01-01

    Isothiocyanates (ITCs) are one of several hydrolysis products of glucosinolates, plant secondary metabolites which are substrates for the thioglucohydrolase myrosinase. Recent pursuits toward the development of synthetic, non-natural ITCs have consequently led to an exploration of generating these compounds from non-natural glucosinolate precursors. Evaluation of the myrosinase-dependent conversion of select non-natural glucosinolates to non-natural ITCs cannot be accomplished using established UV-Vis spectroscopic methods. To overcome this limitation, an alternative HPLC-based analytical approach was developed where initial reaction velocities were generated from non-linear reaction progress curves. Validation of this HPLC method was accomplished through parallel evaluation of three glucosinolates with UV-Vis methodology. The results of this study demonstrate that kinetic data is consistent between both analytical methods and that the tested glucosinolates respond similarly to both Michaelis–Menten and specific activity analyses. Consequently, this work resulted in the complete kinetic characterization of three glucosinolates with Sinapis alba myrosinase, with results that were consistent with previous reports. PMID:25068719

  6. New potential phytotherapeutics obtained from white mulberry (Morus alba L.) leaves.

    Science.gov (United States)

    Gryn-Rynko, Anna; Bazylak, Grzegorz; Olszewska-Slonina, Dorota

    2016-12-01

    The present work demonstrates the profound and unique phyto-pharmacological and nutritional profile of white mulberry (Morus alba L.) leaves which containing considerable amounts of easy digestive proteins, carbohydrates, micro- and macronutrients, polyphenols, free amino acids, organic acids. The wide range of significant biopharmaceutical activities of the aqueous and polar organic solvents extracts from mulberry leaves - including antidiabetic, antibacterial, anticancer, cardiovascular, hypolipidemic, antioxidant, antiatherogenic, and anti-inflammatory - have been critically discussed. The main objective was to demonstrate the results of recently published study on the components of white mulberry leaves exhibiting their biological activity in the various pathological and health human ailments. In addition, we intend to drawn the attention of researchers and public health workers for the extended exploration of this deciduous plant leaves as the source of potential indigenous nutraceuticals and functional food products to enable development of alternative prevention and treatment protocols offered in therapy of the common non-communicable diseases and malignances. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  7. Research Regarding Milk Quality Parameters Obtained in Eight Farms from Alba County

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    eugen claudiu Jurco

    2013-10-01

    Full Text Available The aim of this investigation was to determine the milk quality in terms of somatic cell count (SCC and total germ number (TGN obtained in eight farms from Alba county. The milk for evaluating quality was monthly harvested in sterile tubes and were examined at the Foundation for milk's quality control. Average value per farm of somatic cell count (SCC, the lowest values were on the farm SC Vitis Augusta SRL with 114670 SCC/ml, and the highest average values ​​were recorded on the  farm SC Zooagro SRL with 277330 SCC/ml. Average values per farm of the total germs number (TGN, the lowest values occurred in SC Biotera SRL with 15.83 x1000 germs/ml and SC Vitis Augusta SRL with 17.25 x1000 of germs/ml farms, and the highest average values ​​were recorded in the farms of PFA Munteanu Cornel with 77.75 x1000 germs/ml and SC Zooagro SRL with 93.33 x1000 germs/ml.

  8. Herbicidal Activity of Glucosinolate Degradation Products in Fermented Meadowfoam (Limnanthes alba) Seed Meal

    Science.gov (United States)

    STEVENS, JAN F.; REED, RALPH L.; ALBER, SUSAN; PRITCHETT, LARRY; MACHADO, STEPHEN

    2009-01-01

    Meadowfoam (Limnanthes alba) is an oilseed crop grown in western Oregon. After extraction of the oil from the seeds, the remaining seed meal contains 2-4% of the glucosinolate, glucolimnanthin. We investigated the effect of fermentation of seed meal on its chemical composition and the effect of the altered composition on downy brome (Bromus tectorum) coleoptile emergence. Incubation of enzyme-inactive seed meal with enzyme-active seeds (1% by weight) resulted in complete degradation of glucolimnanthin and formation of 3-methoxybenzyl isothiocyanate in 28% yield. Fermentation in the presence of an aqueous solution of FeSO4 (10 mM) resulted in the formation of 3-methoxyphenylacetonitrile and 2-(3-methoxyphenyl)ethanethioamide, a novel natural product. The formation of the isothiocyanate, the nitrile and the thioamide, as a total, correlated with an increase of herbicidal potency of seed meal (r2 = 0.96). The results of this study open new possibilities for the refinement of glucosinolate-containing seed meals for use as bioherbicides. PMID:19170637

  9. Misunderstanding opportunities: (post-resettlement issues in the Recea neighbourhood of Alba Iulia

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    Cătălin Buzoianu

    2013-06-01

    Full Text Available Although its gold mining project has been locked in public debates and permit reviews for over a decade, a Canadian-Romanian company privately negotiated with the inhabitants of Roşia Montană commune, Romania, to buy their households and lands, and resettle them in a specially built neighbourhood in the city of Alba Iulia. This paper suggests that while the paternalistic character of resettlement has allowed resettlers to partially keep their group identity, and partially to reconstruct it in relation with the host community, it was also based on a misunderstanding of the relationship between resettlers and the organiser of resettlement. Drawing on field research, the resettlement was studied as a “continuous process” spanning three years (2010-12, during which this paper identifies (1 the changes in lifestyle, (2 the mechanisms of community regeneration, and (3 post-resettlement initiatives of resettlers. Although greater living costs (utility bills, real estate taxes, transportation and unemployment seem to be balanced by better living conditions and greater educational opportunities for their children, the ambivalent paternalistic aspect of the resettlement has negatively influenced the development of the new community. While at first community issues were unsuccessfully addressed to the company, recent public improvement initiatives by resettlers have caused tensions between the two sides.

  10. Anesthetic induction and recovery of Hippocampus reidi exposed to the essential oil of Lippia alba

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    Mauro Alves da Cunha

    Full Text Available The aim of this study was to identify the times of anesthetic induction and recovery in slender seahorses (Hippocampus reidi that were exposed to the essential oil of Lippia alba (EO, as well as the efficacy of EO as a stress-reducing agent in the transport of this species. Slender seahorses were placed in 1-L aquaria containing different concentrations of EO (0, 10, 20, 50, 150, 300 and 450 µL L-1, and after induction, fish were transferred to aquaria that were free of anesthetic to evaluate their recovery time. In an additional experiment, slender seahorses were transported in plastic bags with 15 µL L-1 of EO for 4 or 24 h. The increased concentration of EO proportionally decreased the time required for the induction of anesthesia. EO treatment (15 µL L-1 inhibited the increase in blood glucose levels that was provoked by transportation for 4 or 24 h. Transportation for 24 h also decreased the number of lymphocytes and increased the neutrophil count, and these effects were avoided with the addition of EO to the water. These results demonstrate that EO was effective as an anesthetic at concentrations of 10-20 µL L-1 for slight sedation and transport and at 150 µL L-1 for deep anesthesia in the slender seahorse.

  11. Epicuticular wax on stomata of damaged silver fir trees (Abies alba Mili.

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    Tomislav Bačić

    2011-01-01

    Full Text Available Condition of epistomatal wax on the abaxial surface of the current and previous-year needles of damaged silver fir trees (Abies alba Mill., both from the polluted Risnjak and "clean" Donja Dobra sites in Gorski Kotar region, both influenced by pollutants coming from Europe, during two years, three times a year, were examined with Scanning Electron Microscope. In the course of time the wax tubules on the epistomatal rims of stomata in polluted, but also in "clean" needles surface, become fused and agglomerated rapidly to various extents of morphologically different types of amorphous wax crusts, primarily compact and particulate ones. This process begins very early, especially in polluted Risnjak site, and may be interpreted as a possible result of air pollution. However, the recrystalization, or production of new tubules, also appears relatively quickly in mostly cases. Quantitative estimations indicate a very large total amount of amorphous wax crusts in the current-year needles, and a very high percentage of the same wax in previous-year needles. Amorphous wax crusts cover stomatal pores, as well as the rims, disturbing the normal gas exchange. Statistically there is a signicant tendency of increase in wax degradation in the needles of the polluted site in comparison with those of the unpolluted one, but there is an insignificant wax degradation among the needles of damaged trees within each site. These results confirmed most of the research done in our preliminary report.

  12. Barn Owl (Tyto alba Diet Composition on Intensively Used Agricultural Land in the Danube Lowland

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    Tomáš Veselovský

    2017-01-01

    Full Text Available Based on pellets analysis from five localities in south western Slovakia (Malá Mužla, Malé Ripňany, Obid, Opatovský Sokolec and Tešedíkovo, we studied the diet composition of Barn Owl (Tyto alba in intensively cultivated agricultural lands. A total of 6218 specimens of prey, 17 mammalian and 7 bird species were identified. The main prey species found in all food samples was the Common Vole (Microtus arvalis, varying between 56 % and 67 %. The proportion of synanthropic species (Rattus norvegicus, Passer domesticus and species inhabiting agricultural landscapes (Crocidura leucodon, Crocidura suaveolens, Mus sp. increases in localities with a lower ratio of the Common Vole. The results suggest land use affects the diet of Barn Owls, confirming conclusions which have been drawn in previous studies. From faunistic point of view, discovering the Pannonian Root Vole (Microtus oeconomus mehelyi in the diet from Malá Mužla was important.

  13. Antiosteoporotic Effect of Combined Extract of Morus alba and Polygonum odoratum

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    Sudarat Sungkamanee

    2014-01-01

    Full Text Available Due to the limitation of osteoporosis therapy, the alternative therapies from natural sources have been considered. In this study, we aimed to determine the antiosteoporotic effect of the combined extract of Morus alba and Polygonum odoratum leaves. Ovariectomized rats, weighing 200–220 g, were orally given the combined extract at doses of 5, 150, and 300 mg·kg−1 BW for 3 months. At the end of study, blood was collected to determine serum osteocalcin, calcium, and alkaline phosphatase level. In addition, tibia bone was isolated to determine bone oxidative stress markers, cortical bone thickness, and density of osteoblast. The combined extract decreased oxidative stress and osteoclast density but increased osteoblast density and cortical thickness. The elevation of serum calcium, alkaline phosphatase, and osteocalcin was also observed. These results suggested the antiosteoporotic effect of the combined extract via the increased growth formation together with the suppression of bone resorption. However, further studies concerning chronic toxicity and the underlying mechanism are required.

  14. Protective Effect of Morus alba Leaf Extract on N-Nitrosodiethylamine-induced Hepatocarcinogenesis in Rats.

    Science.gov (United States)

    Kujawska, Małgorzata; Ewertowska, Małgorzata; Adamska, Teresa; Ignatowicz, Ewa; Flaczyk, Ewa; Przeor, Monika; Kurpik, Monika; Liebert, Jadwiga Jodynis

    The leaves of white mulberry (Morus alba L.) contain various polyphenolic compounds possessing strong antioxidant activity and anticancer potential. This study was designed to investigate the chemopreventive effect of aqueous extract of mulberry leaves against N-nitrosodiethylamine (NDEA)-induced liver carcinogenesis. Wistar rats were divided into four groups: control, mulberry extract-treated, NDEA-treated, and mulberry extract plus NDEA-treated. Mulberry extract was given in the diet (1,000 mg/kg b.w./day); NDEA was given in drinking water. Mulberry extract reduced the incidence of hepatocellular carcinoma, dysplastic nodules, lipid peroxidation, protein carbonyl formation, and DNA degradation. Treatment with mulberry leaf extract along with NDEA challenge did not affect the activity of antioxidant enzymes and glutathione content. Treatment with mulberry leaf extract partially protected the livers of rats from NDEA-induced hepatocarcinogenesis and a direct antioxidant mechanism appears to contribute to its anticarcinogenic activity. Copyright © 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  15. Root bark of Morus alba ameliorates the depressive-like behaviors in diabetic rats.

    Science.gov (United States)

    Ye, Mei; Ke, Yuting; Liu, Bingyang; Yuan, Yanyan; Wang, Fuyan; Bu, Shizhong; Zhang, Yisheng

    2017-01-10

    Diabetes-induced depression is one of the severe chronic complications of diabetes mellitus. Up to now, there are only a few effective medicines to prevent or manage the co-morbidity of diabetes and depression. The present study was to investigate the effect of root bark of Morus alba (RBM) on depressive-like behaviors in the diabetic rats established by a high fat diet and a low dose of streptozotocin. Depressive-like behaviors were measured by the open field test, locomotor activity test and forced swimming test. Plasma glucose and lipid parameters were also measured. Expression of Brain-derived neurotrophic factor (BDNF) and phosphorylation of extracellular signal-regulated kinase (ERK) and Akt in the prefrontal cortex (PFC) were assessed. The results showed that a 4-week administration of RBM (10g/kg, ig) significantly reversed the depressive-like behaviors. BDNF expression and phosphorylation of ERK and Akt were increased in the PFC following RBM treatment in the diabetic rats. The data demonstrated that RBM could improve the depressive-like behaviors induced by diabetes, suggesting a therapeutic potential of RBM for the diabetes-associated depression. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  16. Galactose-binding lectin from mulberry (Morus alba L. seeds with growth hormone-like activity

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    E. Khurtsidze

    2017-03-01

    Full Text Available Plant lectins are well documented to participate in multiple physiological activities based on selective binding to the carbohydrate structures. They have been reported to play significant roles in various processes such as growth and development, differentiation and plant protection. Nevertheless, the intrinsic roles of plant lectins still remain undefined. We purified a galactose-binding lectin, named MAL, from mulberry (M. alba L. seeds and analyzed its properties. The lectin is composed of one polypeptide of 17 kDa, which is abundant in the seed protein fraction. MAL interacted with GalNAc and galactose residues of saccharides with high binding ability. Western blotting analysis suggested that MAL is deposited in the mulberry leaves and inflorescence. MAL was examined for growth stimulatory activity on mulberry hypocotyls and internodal sections of in vitro grown P. euphratica cultures. Elongation of mulberry hypocotyls was detected in the apical parts of the hypocotyl, where the growth increment was 58%. MAL had no significant effect on the stem elongation and induction of new leaves. Our results suggest that MAL may be involved in the growth and cell elongation at initial stages of tissue development.

  17. Phenotypic and Transcriptomic Analyses of Autotetraploid and Diploid Mulberry (Morus alba L.).

    Science.gov (United States)

    Dai, Fanwei; Wang, Zhenjiang; Luo, Guoqing; Tang, Cuiming

    2015-09-22

    Autopolyploid plants and their organs are often larger than their diploid counterparts, which makes them attractive to plant breeders. Mulberry (Morus alba L.) is an important commercial woody plant in many tropical and subtropical areas. In this study, we obtained a series of autotetraploid mulberry plants resulting from a colchicine treatment. To evaluate the effects of genome duplications in mulberry, we compared the phenotypes and transcriptomes of autotetraploid and diploid mulberry trees. In the autotetraploids, the height, breast-height diameter, leaf size, and fruit size were larger than those of diploids. Transcriptome data revealed that of 21,229 expressed genes only 609 (2.87%) were differentially expressed between diploids and autotetraploids. Among them, 30 genes were associated with the biosynthesis and signal transduction of plant hormones, including cytokinin, gibberellins, ethylene, and auxin. In addition, 41 differentially expressed genes were involved in photosynthesis. These results enhance our understanding of the variations that occur in mulberry autotetraploids and will benefit future breeding work.

  18. Growth, Physiological, Biochemical, and Ionic Responses of Morus alba L. Seedlings to Various Salinity Levels

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    Nan Lu

    2017-12-01

    Full Text Available Mulberry (Morus alba L., a moderately salt-tolerant tree species, is considered to be economically important. In this study, 1-year-old mulberry seedlings cultivated in soil under greenhouse conditions were treated with five concentrations of sodium chloride (NaCl; 0%, 0.1%, 0.2%, 0.3%, and 0.5% for 3 and 21 days. Plant growth parameters were not affected by 0.1% NaCl, but significant reductions were observed after treatment with 0.2%, 0.3%, and 0.5% NaCl. The malondialdehyde content and cell membrane stability of mulberry seedlings exposed to 0.1% NaCl did not change, indicating that mulberry is not significantly affected by low-salinity conditions. The Na contents of various organs did not increase significantly in response to 0.1% NaCl, but the K:Na, Mg:Na, and Ca:Na ratios of various organs were affected by NaCl. Marked changes in the levels of major compatible solutes (proline, soluble sugars, and soluble proteins occurred in both the leaves and roots of NaCl-treated seedlings relative to control seedlings. Under severe saline conditions (0.5% NaCl, the ability of mulberry to synthesize enzymatic antioxidants may be impaired.

  19. Antiosteoporotic Effect of Combined Extract of Morus alba and Polygonum odoratum

    Science.gov (United States)

    Sungkamanee, Sudarat; Thukham-mee, Wipawee

    2014-01-01

    Due to the limitation of osteoporosis therapy, the alternative therapies from natural sources have been considered. In this study, we aimed to determine the antiosteoporotic effect of the combined extract of Morus alba and Polygonum odoratum leaves. Ovariectomized rats, weighing 200–220 g, were orally given the combined extract at doses of 5, 150, and 300 mg·kg−1 BW for 3 months. At the end of study, blood was collected to determine serum osteocalcin, calcium, and alkaline phosphatase level. In addition, tibia bone was isolated to determine bone oxidative stress markers, cortical bone thickness, and density of osteoblast. The combined extract decreased oxidative stress and osteoclast density but increased osteoblast density and cortical thickness. The elevation of serum calcium, alkaline phosphatase, and osteocalcin was also observed. These results suggested the antiosteoporotic effect of the combined extract via the increased growth formation together with the suppression of bone resorption. However, further studies concerning chronic toxicity and the underlying mechanism are required. PMID:25478061

  20. Agrobacterium-mediated transient MaFT expression in mulberry (Morus alba L.) leaves.

    Science.gov (United States)

    Wu, Su-Li; Yang, Xiao-Bing; Liu, Li-Qun; Jiang, Tao; Wu, Hai; Su, Chao; Qian, Yong-Hua; Jiao, Feng

    2015-01-01

    To optimize Agrobacterium-mediated transient transformation assay in mulberry (Morus alba L.), various infiltration methods, Agrobacterium tumefaciens (A. tumefaciens) strains, and bacterial concentrations were tested in mulberry seedlings. Compared with LBA4404, GV3101 harboring pBE2133 plasmids presented stronger GUS signals at 3 days post infiltration using syringe. Recombinant plasmids pBE2133:GFP and pBE2133:GFP:MaFT were successfully constructed. Transient expression of MaFT:GFP protein was found in leaves, petiole (cross section), and shoot apical meristem (SAM) of mulberry according to the GFP signal. Moreover, MaFT:GFP mRNA was also detected in leaves and SAM via RT-PCR and qRT-PCR. An efficient transient transformation system could be achieved in mulberry seedlings by syringe using A. tumefaciens GV3101 at the OD600 of 0.5. The movement of MaFT expression from leaves to SAM might trigger the precocious flowering of mulberry.

  1. Anti-inflammatory activities of compounds from twigs of Morus alba.

    Science.gov (United States)

    Tran, Huynh Nguyen Khanh; Nguyen, Van Thu; Kim, Jeong Ah; Rho, Seong Soo; Woo, Mi Hee; Choi, Jae Sui; Lee, Jeong-Hyung; Min, Byung Sun

    2017-07-01

    Five new compounds, 10-oxomornigrol F (1), (7″R)-(-)-6-(7″-hydroxy-3″,8″-dimethyl-2″,8″-octadien-1″-yl)apigenin (2), ramumorin A (3), ramumorin B (4), and (4S,7S,8R)-trihydroxyoctadeca-5Z-enoic acid (5), together with 31 known compounds (6-36), were isolated from the twigs of Morus alba (Moraceae). The chemical structures of these compounds were established using spectroscopic analyses, 1D and 2D NMR, high-resolution electrospray ionization mass spectrometry (HRESIMS), and Mosher's methods. The anti-inflammatory activities of the compounds were evaluated by investigating their ability to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) production in macrophage RAW 264.7 cells. Compounds 1, 2, 13, 17, 19, 25-28, and 32 showed inhibitory effects with IC 50 values ranging from 2.2 to 5.3μg/mL. Compounds 1, 2, 17, 25, and 32 reduced LPS-induced inducible nitric oxide synthase (iNOS) expression in a concentration-dependent manner. In addition, pretreating the cells with compound 1, 17, and 32 significantly suppressed LPS-induced expression of cyclooxygenase-2 (COX-2) protein. Copyright © 2017. Published by Elsevier B.V.

  2. Analysis and characterisation of phytochemicals in mulberry (Morus alba L.) fruits grown in Vojvodina, North Serbia.

    Science.gov (United States)

    Natić, Maja M; Dabić, Dragana Č; Papetti, Adele; Fotirić Akšić, Milica M; Ognjanov, Vladislav; Ljubojević, Mirjana; Tešić, Živoslav Lj

    2015-03-15

    In this study, the polyphenolic profile of 11 Morus alba fruits grown in the Vojvodina region was investigated. Ultra high performance liquid chromatography (UHPLC) coupled with Linear Trap Quadrupole and OrbiTrap mass analyzer, and UHPLC coupled with a diode array detector and a triple-quadrupole mass spectrometer were used for the identification and quantification of the polyphenols, respectively. A total of 14 hydroxycinnamic acid esters, 13 flavonol glycosides, and 14 anthocyanins were identified in the extracts with different distributions and contents according to the sampling. The total phenolic content ranged from 43.84 to 326.29 mg GAE/100g frozen fruit. The radical scavenging capacity (50.18-86.79%), metal chelating ability (0.21-8.15%), ferric ion reducing power (0.03-38.45 μM ascorbic acid) and superoxide anion radical scavenging activity (16.53-62.83%) were assessed. The findings indicated that mulberry polyphenolics may act as potent superoxide anion radical scavengers and reducing agents. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. The Mulberry (Morus alba L.) Fruit-A Review of Characteristic Components and Health Benefits.

    Science.gov (United States)

    Yuan, Qingxia; Zhao, Longyan

    2017-12-06

    Mulberry (Morus alba L.) fruit has a high yield in one fruiting season in many countries, especially in Asia, and a long history of use as an edible fruit and traditional medicine. A great diversity of nutritive compounds such as fatty acids, amino acids, vitamins, minerals, and bioactive compounds, including anthocyanins, rutin, quercetin, chlorogenic acid, and polysaccharides have been found in mulberry fruit depending on the cultivars and maturity stages. Furthermore, the extracts and active components of mulberry fruit have demonstrated numerous biological activities, including antioxidant, neuroprotective, antiatherosclerosis, immunomodulative, antitumor, antihyperglycemic, and hypolipidemic activities in in vitro and in vivo studies, and they have received increasing interest from researchers and pharmaceutical companies. Although some mechanistic studies further substantiate these potential health benefits of mulberry fruit, a need exists to make a better understanding of the roles of these compounds in traditional medicine and the diet. This review provides recent findings regarding the chemical constituents and biological activities of mulberry fruit, which may be useful for stimulating deep research of mulberry fruit and for predicting their uses as important and safe contributors to benefit human health.

  4. Degradation of exogenous caffeine by Populus alba and its effects on endogenous caffeine metabolism.

    Science.gov (United States)

    Pierattini, Erika C; Francini, Alessandra; Raffaelli, Andrea; Sebastiani, Luca

    2016-04-01

    This is the first study reporting the presence of endogenous caffeine, theobromine, and theophylline in all organs of poplar plants. Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) was used in order to evaluate the uptake, translocation, and metabolism of caffeine-(trimethyl-(13)C) in Populus alba L. Villafranca clone grown in hydroponic conditions. We investigated the remediation of caffeine since it is one of the most widely consumed drugs and it is frequently detected in wastewater treatment plant effluents, surface water, and groundwater worldwide. Our results demonstrated that poplar can absorb and degrade exogenous caffeine without negative effects on plant health. Data showed that concentrations of all endogenous compounds varied depending on caffeine-(trimethyl-(13)C) treatments. In particular, in control conditions, endogenous caffeine, theobromine, and theophylline were mainly distributed in roots. On the other hand, once caffeine-(trimethyl-(13)C) was provided, this compound and its dimethy-(13)C metabolites are mainly localized at leaf level. In conclusion, our results support the possible use of Villafranca clone in association with other water treatment systems in order to complete the process of caffeine remediation.

  5. Evidences of local adaptation in quantitative traits in Prosopis alba (Leguminosae).

    Science.gov (United States)

    Bessega, C; Pometti, C; Ewens, M; Saidman, B O; Vilardi, J C

    2015-02-01

    Signals of selection on quantitative traits can be detected by the comparison between the genetic differentiation of molecular (neutral) markers and quantitative traits, by multivariate extensions of the same model and by the observation of the additive covariance among relatives. We studied, by three different tests, signals of occurrence of selection in Prosopis alba populations over 15 quantitative traits: three economically important life history traits: height, basal diameter and biomass, 11 leaf morphology traits that may be related with heat-tolerance and physiological responses and spine length that is very important from silvicultural purposes. We analyzed 172 G1-generation trees growing in a common garden belonging to 32 open pollinated families from eight sampling sites in Argentina. The multivariate phenotypes differ significantly among origins, and the highest differentiation corresponded to foliar traits. Molecular genetic markers (SSR) exhibited significant differentiation and allowed us to provide convincing evidence that natural selection is responsible for the patterns of morphological differentiation. The heterogeneous selection over phenotypic traits observed suggested different optima in each population and has important implications for gene resource management. The results suggest that the adaptive significance of traits should be considered together with population provenance in breeding program as a crucial point prior to any selecting program, especially in Prosopis where the first steps are under development.

  6. Herbicidal activity of glucosinolate degradation products in fermented meadowfoam ( Limnanthes alba ) seed meal.

    Science.gov (United States)

    Stevens, Jan F; Reed, Ralph L; Alber, Susan; Pritchett, Larry; Machado, Stephen

    2009-03-11

    Meadowfoam ( Limnanthes alba ) is an oilseed crop grown in western Oregon. After extraction of the oil from the seeds, the remaining seed meal contains 2-4% of the glucosinolate glucolimnanthin. This study investigated the effect of fermentation of seed meal on its chemical composition and the effect of the altered composition on downy brome ( Bromus tectorum ) coleoptile emergence. Incubation of enzyme-inactive seed meal with enzyme-active seeds (1% by weight) resulted in complete degradation of glucolimnanthin and formation of 3-methoxybenzyl isothiocyanate in 28% yield. Fermentation in the presence of an aqueous solution of FeSO(4) (10 mM) resulted in the formation of 3-methoxyphenylacetonitrile and 2-(3-methoxyphenyl)ethanethioamide, a novel natural product. The formation of the isothiocyanate, the nitrile, and the thioamide, as a total, correlated with an increase of herbicidal potency of the seed meal (r(2) = 0.96). The results of this study open new possibilities for the refinement of glucosinolate-containing seed meals for use as bioherbicides.

  7. NOTES ON A STATUE FROM THE COLLECTIONS OF THE NATIONAL MUSEUM OF UNION FROM ALBA IULIA

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    Andreea Almăjanu

    2016-04-01

    Full Text Available This study proposes to re-evaluate a marble statue from the old collections of the National Museum of Union Alba Iulia. It was discovered by A. Cserni during excavations carried out at the Palace of the Governors of Roman Dacia, in 1898. It has been repeatedly published by Á. Hekler and Al. Diaconescu. While the latter author established dating and iconographic prototype of the statue, we believe that further details as discovery place and context, depiction, iconographic attribution and role of this work of art can be offered. Presence of a follower at the feet of the divinity, more precisely the right foot of a character – child, conveys us the idea of depiction of Eros, god of love. Usually, this is depicted beside nude or seminude Venus, and sculptural representation from Apulum is somehow different from iconographic point of view. As we see it, taking into consideration the discovery place, artefacts resulted from the same excavation, artistic eclecticism, religious iconographic influences and official politics of the Roman state, we believe we are dealing with rather an unusual statue of Venera as manner of representation or an image of an empress, wife of a governor or member of a family of municipal authorities from Apulum.

  8. Albas y alboradas en el cancionero tradicional mexicano: herencia y cambio

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    Masera, Mariana

    1999-12-01

    Full Text Available The roots of some erotic motives in Mexican traditional songs in Spanish could be traced to the Medieval Popular Hispanic songs, as has been said by scholars. But, until now, nobody has studied in depth the relationship and diversity between the Mexican cancionero and old Spanish songs. In this article I shall analize the preservation of the Dawn motif, and all those associated with it, in Mexican Contemporary Songs and variation.Los antecedentes de algunos motivos eróticos de la poesía tradicional mexicana contemporánea en español se pueden rastrear hasta las canciones populares hispánicas de la Edad Media. Sin embargo, aún hoy no se han estudiado en profundidad las relaciones y desencuentros entre la canción popular mexicana y la antigua canción peninsular; por ello, este trabajo se propone como un primer análisis. El estudio resalta la originalidad de las coplas mexicanas a través de un estudio comparativo del motivo del alba.

  9. Long-distance transport of pertechnetate in the moonflower (Ipomoea alba)

    International Nuclear Information System (INIS)

    Clarke, Simon J.; Rogiers, Suzy Y.; Currie, Geoffrey M.

    2012-01-01

    The first research on the transport of metastable-technetium-99 ( 99m Tc) in the form of pertechnetate ( 99m TcO 4 − ) within plants suggested that 99m TcO 4 − may be mobile in the phloem. In contrast, more recent evidence indicates the anion is transported in the xylem. Here we demonstrate that observations of 99m Tc transport in the test subject of these initial investigations, the moonflower (Ipomoea alba L.), are incompatible with phloem flow. Rather, the presence of only minute amounts of 99m Tc in typical sinks for phloem solutes and 99m Tc transport out of labeled leaves when shaded but not when illuminated strongly suggest that the radionuclide is transported in the xylem. The study increases confidence in the identification of 99m TcO 4 − as a xylem mobile compound whose distribution in plants can be visualized using nuclear medicine scintigraphic imaging techniques. - Highlights: ► The vascular transport pathway of metastable-technetium-99 in plants is not clear. ► Nuclear medicine techniques were used to obtain images of 99m Tc in the moonflower. ► Translocation of the radionuclide is incompatible with transport by the phloem. ► 99m Tc transport characteristics are those of a xylem-mobile nutrient analog. ► The research has implications for 99m Tc as a tracer and modeling 99 Tc uptake.

  10. Helminth communities of two species of piscivorous birds, Ardea alba (Linnaeus) and Nyctanassa violacea (Gmelin) (Ciconiiformes: Ardeidae), in two coastal lagoons from Guerrero state, Mexico.

    Science.gov (United States)

    Violante-González, Juan; Monks, Scott; Gil-Guerrero, Salvador; Rojas-Herrera, Agustín A; Flores-Rodríguez, Pedro

    2012-07-01

    The composition and species richness in helminth communities of two species of heron, Ardea alba and Nyctanassa violacea, in two coastal lagoons from Guerrero, Mexico were examined. Nineteen species of helminth (7,804 individuals) were identified in 43 adult birds: 15 digeneans, 1 acanthocephalan, 1 cestode, and 2 nematodes. Eight species co-occurred in herons of both species and lagoons. The prevalence values of seven species and the mean abundance of five species varied significantly between species of birds and between lagoons. The heterophyid, Ascocotyle (Phagicola) longa, was the helminth numerically dominant in the helminth community of A. alba in both lagoons, while the cestode, Parvitaenia cochlearii, dominated the community of N. violacea. At the component community level, species richness varied significantly: 10 species in A. alba from Coyuca to 16 in N. violacea (Tres Palos). All of the birds examined were infected with helminth parasites: three to seven species per host in A. alba from Coyuca, and two to eight species in A. alba and N. violacea from Tres Palos. The results indicate that even though species composition was similar between both species of heron, the structure of their communities was not the same. Differences in the feeding behavior of the birds (day/night habits), as well as local differences in the abundance of species of fish, and infection levels of helminths in each lagoon are suggested as being responsible for the variations registered in the structure of the helminth communities.

  11. Morus alba L. Stem Extract Attenuates Pain and Articular Cartilage Damage in the Anterior Cruciate Ligament Transection-Induced Rat Model of Osteoarthritis.

    Science.gov (United States)

    Khunakornvichaya, Arada; Lekmeechai, Sujinna; Pham, Phi Phuong; Himakoun, Wanwisa; Pitaksuteepong, Tasana; Morales, Noppawan Phumala; Hemstapat, Warinkarn

    2016-01-01

    This study was designed to investigate the anti-nociceptive effect of Morus alba stem extract as well as its cartilage protective effect in the anterior cruciate ligament transection (ACLT)-induced rat model of osteoarthritis (OA). The anti-nociceptive effect of this plant extract was determined by measuring hind limb weight bearing, while the severity of cartilage damage to the knee joints was evaluated using the modified Mankin grading system. Oral administration of M. alba stem extract (56 and 560 mg/kg) significantly attenuated joint pain as indicated by a significant (p alba stem extract at 56 and 560 mg/kg when compared to those of the vehicle-treated OA-induced group. In addition, a significant improvement in the Mankin score was also observed in rats treated with 560 mg/kg M. alba stem extract, which was in agreement with its pain-relieving effect. The results showed that M. alba stem extract exhibited an anti-nociceptive effect as well as cartilage protection in the ACLT-induced rat model of OA, supporting its potential use as a therapeutic treatment for OA. © 2016 S. Karger AG, Basel.

  12. Inhibitory effects of ethyl acetate-soluble fraction from morus alba on lipid accumulation in 3T3-L1 cells.

    Science.gov (United States)

    Park, Hee-Sook; Shim, Soon-Mi; Kim, Gun-Hee

    2013-11-01

    Fruits of mulberry (Morus alba) have been widely used for therapeutic purposes in Asian countries for centuries. Treatment of 3T3-L1 cells with ethanolic extracts of M. alba decreased adipocyte differentiation at 100 microg/mL by 18.6%. Treatment suppressed mRNA levels of PPARgamma and C/EBPalpha expression in 3T3-L1 cells. However, the extract did not change free glycerol release from mature adipocytes. Thus, M. alba inhibited lipid accumulation by regulating transcription factors in 3T3-L1 adipocytes without a lipolytic effect. Among the soluble- fractions, the ethyl acetate-soluble fraction had the highest antiadipogenic effects on 3T3-L1 cells. This fraction decreasing intracellular lipid accumulation by 38.5% in response to treatment with 100 microg/mL. In addition, HPLC analysis of the ethyl acetate-soluble fraction of M. alba contained 167.7 microM of protocatechulic acid in 1 mg/mL of fraction, which inhibited lipid accumulation by 44.8% in response to treatment with 100 microM. From these results, M. alba is a possible candidate for regulating lipid accumulation in obesity.

  13. Cross-curricular goals and raising the relevance of science education

    DEFF Research Database (Denmark)

    Belova, Nadja; Dittmar, Johanna; Hansson, Lena

    2017-01-01

    ‘Relevance’ is one of the most commonly used terms when it comes to reforms in science education. The term is used in manifold ways. It can be understood – among other things – as meeting an interest, fulfilling needs or contributing to intellectual development. Many components of relevant science...... education go beyond single contents and concepts; many challenges are tied to cross-curricular goals. Specifically, when it comes to the societal and vocational relevance of science education, many demands can only be met when we develop corresponding skills across disciplines and grade levels. This chapter...... focuses on a set of such cross-curricular goals from a chemistry education perspective, namely, education for sustainability, critical media literacy, innovation competence, vocational orientation and employability. It relates them to the idea of relevant chemistry and science education. Directions...

  14. Aligning Science Achievement and STEM Expectations for College Success: A Comparative Study of Curricular Standardization

    Directory of Open Access Journals (Sweden)

    Siqi Han

    2016-04-01

    Full Text Available Lack of preparation in science leads to high rates of attrition among science, technology, engineering, and mathematics (STEM majors, even among students who are highly oriented toward STEM. Using data for twenty-seven countries from the 2006 Program for International Student Assessment, we compare the United States with other industrialized countries in terms of fifteen-year-olds’ science achievement and their expectations to focus on STEM in the future. The United States trails most countries in the mean science achievement of the general student population and among students expecting to pursue STEM majors or careers. Lack of curricular standardization in the United States is related to this lower science achievement. Countries with higher curricular standardization exhibit higher average science achievement scores; science achievement and students’ future orientation toward science are also better aligned in these countries. We discuss the implications of these findings for American colleges and universities as they seek to reduce student attrition in STEM fields.

  15. One Health in food safety and security education: A curricular framework.

    Science.gov (United States)

    Angelos, J; Arens, A; Johnson, H; Cadriel, J; Osburn, B

    2016-02-01

    The challenges of producing and distributing the food necessary to feed an anticipated 9 billion people in developed and developing societies by 2050 without destroying Earth's finite soil and water resources present extremely complex problems that lack simple solutions. The ability of modern societies to adequately address these and other food-related problems will require an educated workforce trained not only in traditional food safety, security, and public health, but also in other areas including food production, sustainable practices, and ecosystem health. To help address the need for such an educated workforce, a curricular framework was developed to assist those tasked with designing education and training for future food systems workers. One sentence summary: A curricular framework for education and training in food safety and security was developed that incorporates One Health concepts. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  16. Ethical and Civic Education. Difficulties during the Curricular Reform in Argentine Patagonia

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    Isabelino Siede

    2015-04-01

    Full Text Available DOI: http://dx.doi.org/10.17227/01234870.41folios51.68 What type of ethical and civic education is effectively provided at school? This article analyzes the curricular prescriptions of Ethical and Citizenship Education in primary schools of the Argentine Patagonia, as well as its relations and contradictions with the school practices of moral education It inquires the process of definition of the area in the context of the Educational Reform in the 90s. Also, it pursuits to remake the way it was incorporated in the provincial curriculum design. Throughout focus groups and interviews to teachers from different public and private schools of three towns from de north of Santa Cruz, we analyze the descriptions and expectative of the teachers about their teaching practice in the moral area, as well as the possible causes of the differences and the contradictions between the policies of the curricular statement and educational proposals offered at school.

  17. Programa curricular de la segunda especialidad en formación magisterial

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    Elsa Tueros Way

    1993-06-01

    Full Text Available Este documento presenta las demandas para la formación de docentes objetivos de la Segunda Especialidad, se definen los perfiles real e ideal del docente de ISPs y se señalan los requisitos de los usuarios de este programa. Estos elementos sirven para sustentar la Estructura Curricular: Areas de estudio (Investigación Educativa,Teoría y Realidad Educativa, Diseño y Evaluación del Curriculum,y Desarrollo Comunal y Regional, el Plan de estudios y la descripciónde los cursos. Asimismo, se señala la estrategia que se empleará para el desarrollo curricular incluída la evaluación.

  18. Las adecuaciones curriculares como elemento clave para asegurar una educación inclusiva

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    Zuleima Corredor Ponce

    2016-01-01

    Full Text Available El presente trabajo versa sobre una revisión documental realizada con el objetivo de sistematizar algunas prácticas educativas, orientadas a asegurar el éxito escolar de los niños que manifiestan algún tipo de necesidad educativa especial. Surge de la necesidad detectada por los estudiantes de la Carrera de Educación mención Dificultades de Aprendizaje del Centro Local Zulia, quienes en sus prácticas profesionales observan la falta de preparación por parte de los docentes para incorporar adecuaciones curriculares. La metodología utilizada consistió en la revisión documental de artículos académicos y textos especializados, para conceptualizar y esbozar un conjunto de consideraciones a fin de aplicar adecuaciones curriculares.

  19. Awareness, Analysis, and Action: Curricular Alignment for Student Success in General Chemistry

    Science.gov (United States)

    2018-01-01

    This article examines the ways that a shared faculty experience across five partner institutions led to a deep awareness of the curriculum and pedagogy of general chemistry coursework, and ultimately, to a collaborative action plan for student success. The team identified key differences and similarities in course content and instructional experiences. The comparative analysis yielded many more similarities than differences, and therefore, the team shifted its focus from “gap analysis” to an exploration of common curricular challenges. To address these challenges, the team developed content for targeted instructional resources that promoted the success of all STEM students across institutions. This article contextualizes the interinstitutional collaboration and closely examines the interactive components (awareness, analysis, and action), critical tools, and productive attitudes that undergirded the curricular alignment process of the STEM Transfer Student Success Initiative (t-STEM). PMID:29657334

  20. Estrategia curricular para la formación pedagógica en la carrera de Medicina Curricular strategy for the pedagogical training in Medicine course

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    Cecilia Valdés de la Rosa

    2010-08-01

    Full Text Available El Médico General Básico egresado debe poseer una cultura pedagógica que le proporcione las herramientas para desempeñar la función docente contemplada en su perfil profesional. El siguiente trabajo presenta una estrategia curricular para desarrollar la formación pedagógica de los estudiantes de Medicina. Las acciones propuestas están dirigidas en dos vertientes: una para el desarrollo de la labor educativa con el individuo, la familia y la comunidad, y la otra encaminada a la función docente en la educación médica de pregrado.Graduate practitioners must have a pedagogical culture that offers them tools to carry out the teaching function described in their professional pattern. This article presents a curricular strategy to train medical students in teaching. Actions are focused on two trends: to develop educational work with the individual, the family and the community, and to function as a professor of career courses.

  1. Pedagogic project of the Environmental Engineering Course of UNIPINHAL: structure, curricular emphasis and approaches

    OpenAIRE

    Maurício Salvetti; Marcelo Della Mura Jannini; Maria Eugenia Garcia Porto; Celso Henrique Zuppi da Conceição; Maristela Della Libera Reis Piccinini; Marta Wilk Donida; Ana Claudia Camargo Lima Tresmondi; Rogéria Maria Alves de Almeida; Nirlei Maria Oliveira; André Luis Paradela; Carlos Antonio Centurion Maciel; Gilberto José Hussar; Fabio Augusto Gomes Vieira Reis; Gerson Araujo de Medeiros; Mônica Luri Giboshi

    2006-01-01

    The courses of environmental engineering have increasingly become more common in Brazil. In spite of the common legislation that defines the subjects of basic, professional and specific graduation, there has been a variation in the focus given in the list of subjects of these courses, which have been strongly influenced by the vocation of the Institution of Undergraduate Teaching (IES). The objective of this essay is to present the structure, the curricular emphasis and the approaches used by...

  2. Adaptaciones curriculares: Convergencias y divergencias de su implementación en el profesorado chileno

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    Braulio Ademir Navarro-Aburto

    2016-01-01

    Full Text Available Recibido 13 de marzo de 2015 • Corregido 29 de octubre de 2015 • Aceptado 17 de noviembre de 2015La presente investigación describe el proceso que se realiza para llevar a cabo las adaptaciones curriculares, en la asignatura de matemática para el alumnado que presenta algún tipo de necesidad educativa especial transitoria. Se ha considerado la coordinación existente entre docentes de Matemática y de Educación Diferencial, como acción promotora de las adaptaciones curriculares. La metodología utilizada corresponde a la cualitativa con un enfoque fenomenológico, y la principal técnica de recolección de datos fue la entrevista semiestructurada, participantes de este estudio fueron 10 docentes de 2 instituciones educativas con programa de integración. Los principales hallazgos arrojan que profesorado y personal encargados del Programa de Integración Escolar cumplen con las normativas y requerimientos  del Decreto Nº 170 en relación con las adaptaciones curriculares, pero dicho cumplimiento está sujeto a la informalidad en la articulación y planificación debido a la falta de tiempo y recursos disponibles. De este modo, como conclusión se plantea que existe una necesidad constante de adaptaciones curriculares, pues son un mecanismo que permite lograr la individualización de la enseñanza, mejorando la calidad de vida y la educación especial en Chile.

  3. Addressing curricular innovation in a multi-stakeholder environment: Planning to change

    OpenAIRE

    Enslen, Todd

    2001-01-01

    As language innovations move outside the boundaries of autonomous departmental units, the process of change through the planning, design and implementation phases become more complex. Therefore, there is a greater need for awareness of the steps in the innovation process. This is especially true for the planning process since the adoption decision is divided amongst potentially numerous potential adopters. This paper will present a case study of curricular innovation, a move from an EAP to an...

  4. Programa curricular de Ingeniería Eléctrica

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    Revista Ingeniería e Investigación

    2001-01-01

    Full Text Available La Ingeniería Eléctrica se ocupa del estudio de los elementos y sistemas necesarios para la generación, transporte, distribución, consumo de la energía eléctrica y uso de la electricidad en general. En este artículo se presentan aspectos relacionados con el programa curricular de la carrera.

  5. Medical student mental health 3.0: improving student wellness through curricular changes.

    Science.gov (United States)

    Slavin, Stuart J; Schindler, Debra L; Chibnall, John T

    2014-04-01

    Medical education can have significant negative effects on the well-being of medical students. To date, efforts to improve student mental health have focused largely on improving access to mental health providers, reducing the stigma and other barriers to mental health treatment, and implementing ancillary wellness programs. Still, new and innovative models that build on these efforts by directly addressing the root causes of stress that lie within the curriculum itself are needed to properly promote student wellness. In this article, the authors present a new paradigm for improving medical student mental health, by describing an integrated, multifaceted, preclinical curricular change program implemented through the Office of Curricular Affairs at the Saint Louis University School of Medicine starting in the 2009-2010 academic year. The authors found that significant but efficient changes to course content, contact hours, scheduling, grading, electives, learning communities, and required resilience/mindfulness experiences were associated with significantly lower levels of depression symptoms, anxiety symptoms, and stress, and significantly higher levels of community cohesion, in medical students who participated in the expanded wellness program compared with those who preceded its implementation. The authors discuss the utility and relevance of such curricular changes as an overlooked component of change models for improving medical student mental health.

  6. Teacher training: challenges and possibilities of teaching of reproduction and sexuality in supervised curricular stage

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    Mayara Lustosa de Oliveira

    2012-02-01

    Full Text Available This work has its origins in a survey conducted during the supervised curricular stage of Biological Sciences course at Federal University of Goiás. The article describes critically and analytically every step of the curricular stage, especially the classes with the themes: reproduction and sexuality. The classes were taught to elementary students in State College St. Bernadete in Goiânia-GO. To facilitate the process of teaching and learning the trainees divided the themes into subtopics, and several teaching resources were developed for each subtopic. The research was descriptive and exploratory, using interviews with school students, teachers, supervisors and college students to collect data that allowed assessing the success of the teaching methodologies applied by the teachers in training. The field diaries of the trainees were also used to compose the analysis. Through the statements of the participants, it is considered that the methods achieved their goal in clarifying the issues. The resources used not only brought understanding, but encouraged the participation of the students. The article has been organized according to the steps of the curricular stage and it exposes all the impressions of the supervising teachers, school students and undergraduates during the internship, highlighting, comments, concerns, planning and execution process of the activities.

  7. Leadership lessons from curricular change at the University of California, San Francisco, School of Medicine.

    Science.gov (United States)

    Loeser, Helen; O'Sullivan, Patricia; Irby, David M

    2007-04-01

    After successive Liaison Committee on Medical Education accreditation reports that criticized the University of California, San Francisco, School of Medicine for lack of instructional innovation and curriculum oversight, the dean issued a mandate for curriculum reform in 1997. Could a medical school that prided itself on innovation in research and health care do the same in education? The authors describe their five-phase curriculum change process and correlate this to an eight-step leadership model. The first phase of curricular change is to establish a compelling need for change; it requires leaders to create a sense of urgency and build a guiding coalition to achieve action. The second phase of curriculum reform is to envision a bold new curriculum; leaders must develop such a vision and communicate it broadly. The third phase is to design curriculum and obtain the necessary approvals; this requires leaders to empower broad-based action and generate short-term wins. In the fourth phase, specific courses are developed for the new curriculum, and leaders continue to empower broad-based action, generate short-term wins, consolidate gains, and produce more change. During the fifth phase of implementation and evaluation, leaders need to further consolidate gains, produce more change, and anchor new approaches in the institution. Arising from this experience and the correlation of curricular change phases with leadership steps, the authors identify 27 specific leadership strategies they employed in their curricular reform process.

  8. The curricular training and the didactics in training of teachers: challenges and possibilities

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    Cyntia Graziella Guizelim Simões Girotto

    2013-01-01

    Full Text Available In this paper we addressed aspects of the disciplines “Curricular Training” and “Didactics” in the Pedagogy Course in training of teachers. The main objective is to emphasize upon submission of the work that we do in our teaching practice in the mentioned disciplines, the importance of linking the theory and the practice in training of teachers so that the teaching in the university it is not decontextualized but enriched with the issues of everyday school life. In this sense, we address, initially, the aspects of the Curricular training as a mediator link of the learning, of the articulation of the curriculum and of the practices and, in this view, as a productive conduit between the university and the basic education, stressing the need for the reception of the contribution that each institutions within its specificity, must provide in the training courses. In sequence, we present aspects of the structure of the work we do with our students in Early Childhood Education Curricular Training. Finally, are detailed the aspects of a Didactics for the teachers of early childhood education and for the early years of Fundamental Education, focusing on narratives of in-service teachers on their experiences teaching in search of new systematization of pedagogical practice and on by own teachers.

  9. Curricular guidelines and citizenship attitudes in Latin American students: a comparative analysis

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    Martín Bascopé, Chile

    2015-07-01

    Full Text Available (analítico: Los currículos son progresivamente relevantes para educar futuros ciudadanos activos. En este contexto, se vuelve fundamental explorar la relación entre las directrices curriculares y cómo la educación ciudadana es efectivamente alcanzada por los estudiantes en países Latinoamericanos. Por ello este artículo tiene por objetivo evaluar comparativamente la visión institucional expresada en cada currículum y las perspectivas de los estudiantes sobre asuntos ciudadanos. El análisis factorial exploratorio y el análisis estadístico descriptivo curricular se basan en dos fuentes valiosas y complementarias, respectivamente: El Estudio Internacional de Educación Cívica y Ciudadana (ICCS y el Sistema Regional de Competencias de Ciudadanía (Sredecc. Luego de una comparación sistemática de ambas fuentes este estudio revela que varios aspectos curriculares son coherentes con las actitudes y creencias de los estudiantes, y sugiere pautas para mejorar y expandir la educación ciudadana en América Latina, considerando la importancia de esta para la formación de una ciudadanía activa.

  10. O perfil do pedagogo no contexto das reformulações curriculares

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    Joslaine Domingues Pedrozo

    2017-01-01

    Full Text Available Este artigo é parte integrante do projeto da pesquisa de Iniciação Científica, vinculada a Universidade Estadual do Centro Oeste (PR cujo título “Pedagogia em questão: desafios e perspectiva atuais”, que têm por objetivo analisar as principais mudanças do curso de Pedagogia, a partir das Diretrizes Curriculares do Ministério da Educação do ano de 2005. O olhar para essas mudanças fundamenta-se nos estudos sobre a temática em questão. Neste trabalho priorizamos a análise dos reflexos das Diretrizes Curriculares (2005, no curso de Pedagogia Irati, pautados nos diferentes olhares: dos professores que vivenciaram as mudanças processadas no curso a partir de 2005, dos egressos do curso e acadêmicos que fazem parte da nova grade curricular. A justificativa para a realização da pesquisa é centrada na necessidade de analisar as continuidades e rupturas do Curso de Pedagogia, para uma possível análise crítica sobre os desafios e perspectivas atuais para o curso.

  11. ON CURRICULAR PROPOSALS OF THE PORTUGUESE LANGUAGE: A DOCUMENT ANALYSIS IN JUIZ DE FORA (MG

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    Tânia Guedes MAGALHÃES

    2014-12-01

    Full Text Available This paper, whose objective is to analyze two curricular proposals of Portuguese from the Juiz de Fora City Hall (2001 and 2012, is an extract from a research entitled “On text genres and teaching: a collaborative research with teachers of Portuguese” (2011/2013. Text genres have been suggested by curricular proposals as a central object for teachers who work with Portuguese language teaching; for this, it is relevant to analyze the documents in the realm of the ongoing research. As theoretical references, we used authors who propose a didactic model based on the development of language skills and linguistic reasoning (MENDONÇA, 2006 which in turn are based on an interactional conception of language (BRONCKART, 1999; SCHNEUWLY; DOLZ, 2004. Document analysis was used as methodology, which envisions assessment of pieces of information in documents as well as their outcomes. The data show that the 2012 curricular proposal is more adequate to Portuguese language teaching than the first one, mainly for its theoretical and methodological grounding, which emphasize the development of students’ linguistic and discursive skills. Guided by an interactionist notion – unlike the norm-centered 2001 proposal – the 2012 document fosters the development of linguistic reasoning and usage skills.

  12. Integración latinoamericana en la Web: Diseño de un sitio en Internet para la difusión del ALBA

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    Raquel Álvarez

    2008-12-01

    Full Text Available The Bolivarian Alternative for the Peoples of the Americas (ALBA, is presented as a proposal to help solve social crises of the people and continue efforts to achieve unity, especially among the countries linked by geography, history or culture. The design of a Web site as a strategy for the dissemination of this proposal is justified largely by the high penetration has had Internet in recent times in Latin America and the world. In the study, it was applied interviews to a group of experts (journalists, lawyers, researchers and university teachers and social promoters, who provided different views the knowledge of ALBA. The Web site that was designed to disseminate the proposed integration ALBA has a presence on the Internet under the domain www.alternativabolivariana.com.ve, and it has a navigation menu that includes an information forum, download, contact and interviews.

  13. Antioxidant Capacity and HPLC-DAD-MS Profiling of Chilean Peumo (Cryptocarya alba Fruits and Comparison with German Peumo (Crataegus monogyna from Southern Chile

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    Mario J. Simirgiotis

    2013-02-01

    Full Text Available Liquid chromatography (LC coupled with UV detection and electrospray ionization (ESI tandem mass spectrometry (MS/MS was used for the generation of chemical fingerprints and the identification of phenolic compounds in peumo fruits and aerial parts from southern Chile. Thirty three compounds (19 of these detected in C. alba and 23 in C. monogyna were identified, mainly flavonoid glycosides, phenolic acids, anthocyanins and flavonoid aglycons. Total phenolic content and total flavonoid content was measured for both species, and were higher in the extracts from C. monogyna fruits and aerial parts than extracts from C. alba. The fruits of Cryptocarya alba (Chilean peumo presented high antioxidant capacity (9.12 ± 0.01 mg/mL in the DPPH assay, but was three times lower to that of Crataegus monogyna (German peumo (3.61 ± 0.01 mg/mL in the DPPH assay.

  14. Fungitoxicty of Bidens pilosa, Thymus vulgaris, Lippia alba and Rosmarinus officinalis in the in vitro development of phytophatogens fungi / Fungitoxidade de Bidens pilosa, Thymus vulgaris, Lippia alba e Rosmarinus officinalis no desenvolvimento in vitro de fungos fitopatogênicos

    Directory of Open Access Journals (Sweden)

    José Renato Stangarlin

    2009-07-01

    Full Text Available The fungitoxicity of aqueous crude extracts (ACE of Bidens pilosa, Thymus vulgaris, Lippia alba and Rosmarinus officinalis was evaluated in vitro on development of Alternaria alternata, Colletotrichum graminicola, Rhizoctonia solani and Sclerotium rolfsii. The active ACE were incorporated to Potato- Dextrose-Agar (PDA alone or in mixture, at 0%, 1%, 5%, 10%, 15%, 25% and 50% concentrations. Measurement in fungal colonies was taken daily until the control treatment covered 2/3 of the culture media. The mixtures of T. vulgaris with B. pilosa did not have positive effect because the ACE of B. pilosa did not reduce the fungal growth of R. solani and in mixture inhibited the effect ACE of T. vulgaris. However, the mixture of ACEs of R. officinalis and L. alba produced better results than isolated ACEs, with 60% of growth inhibition of A. alternata. The ACE of T. vulgaris inhibited the growth of C. graminicola at 97%. The results show that ACEs have significative fungitoxicity in the evaluated phythopathogens.Avaliou-se in vitro, a atividade fungitóxica dos extratos brutos aquosos (EBA em diferentes concentrações isolados e em misturas de Bidens pilosa, Thymus vulgaris, Lippia alba e Rosmarinus officinalis no desenvolvimento dos fungos Alternaria alternata, Colletotrichum graminicola, Rhizoctonia solani e Sclerotium rolfsii. A avaliação foi realizada incorporando os extratos brutos aquosos (EBAs ao meio BDA isolados e em mistura, nas concentrações 0%, 1%, 5%, 10%, 15%, 25% e 50%. Foram feitas medições diárias das colônias fúngicas até o momento em o tratamento controle cobriu 2/3 da superfície do meio de cultura. Verificou-se que a mistura de T. vulgaris com B. pilosa não teve efeito positivo, pois o EBA isolado de B. pilosa não reduziu o crescimento do fungo R. solani e em mistura reduziu o efeito do EBA de T. vulgaris. Porém, o EBAs de R. officinalis e L. alba em mistura levaram a melhores resultados, reduzindo em até 60% o

  15. Política curricular no Estado de São Paulo nos anos 1980 e 1990 Curricular policy in the State of São Paulo in the eighties and nineties

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    Rosa Fátima de Souza

    2006-04-01

    Full Text Available Este texto apresenta um estudo sobre a política curricular implementada no Estado de São Paulo nas décadas de 1980 e 1990 para as primeiras séries do ensino fundamental. Examina o currículo prescrito cotejando-o com os contextos práticos de desenvolvimento do currículo. A pesquisa revela que a política curricular desse período articulou-se fortemente com a produção acadêmica em educação. Ressalta ainda a continuidade na política de produção de materiais de orientação curricular nos últimos 20 anos, buscando difundir e tornar hegemônico um pensamento pedagógico inovador. Também verifica que esses materiais circularam de diferentes formas na rede de ensino e foram apropriados de maneira seletiva pelos professores que adotaram, sobretudo, as indicações práticas.Study on the curricular policy for the first grades of elementary school implemented in the State of São Paulo in the eighties and nineties. It examines the prescribed curriculum by comparing it to the practical contexts of curricular development. The research reveals that the curricular policy of that period was very much connected with academic production on education. It further emphasizes continuity in the policy of producting curricular orientation materials in the last 20 years, in order to advertise and make hegemonic an innovative pedagogical thought. It was also verified that these materials circulated in many different ways within the education system and were selectively appropriated by the teachers who particularly adopted the practical indications.

  16. Past and future evolution of Abies alba forests in Europe - comparison of a dynamic vegetation model with palaeo data and observations.

    Science.gov (United States)

    Ruosch, Melanie; Spahni, Renato; Joos, Fortunat; Henne, Paul D; van der Knaap, Willem O; Tinner, Willy

    2016-02-01

    Information on how species distributions and ecosystem services are impacted by anthropogenic climate change is important for adaptation planning. Palaeo data suggest that Abies alba formed forests under significantly warmer-than-present conditions in Europe and might be a native substitute for widespread drought-sensitive temperate and boreal tree species such as beech (Fagus sylvatica) and spruce (Picea abies) under future global warming conditions. Here, we combine pollen and macrofossil data, modern observations, and results from transient simulations with the LPX-Bern dynamic global vegetation model to assess past and future distributions of A. alba in Europe. LPX-Bern is forced with climate anomalies from a run over the past 21 000 years with the Community Earth System Model, modern climatology, and with 21st-century multimodel ensemble results for the high-emission RCP8.5 and the stringent mitigation RCP2.6 pathway. The simulated distribution for present climate encompasses the modern range of A. alba, with the model exceeding the present distribution in north-western and southern Europe. Mid-Holocene pollen data and model results agree for southern Europe, suggesting that at present, human impacts suppress the distribution in southern Europe. Pollen and model results both show range expansion starting during the Bølling-Allerød warm period, interrupted by the Younger Dryas cold, and resuming during the Holocene. The distribution of A. alba expands to the north-east in all future scenarios, whereas the potential (currently unrealized) range would be substantially reduced in southern Europe under RCP8.5. A. alba maintains its current range in central Europe despite competition by other thermophilous tree species. Our combined palaeoecological and model evidence suggest that A. alba may ensure important ecosystem services including stand and slope stability, infrastructure protection, and carbon sequestration under significantly warmer

  17. In Vitro Antibacterial and Antibiofilm Activity of Lippia alba Essential Oil, Citral, and Carvone against Staphylococcus aureus

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    Emanuela Mesquita Porfírio

    2017-01-01

    Full Text Available In vitro antimicrobial and antibiofilm activities of the Lippia alba essential oil and its major components (citral and carvone against Staphylococcus aureus were investigated. Essential oils (LA1EO, LA2EO, and LA3EO were extracted from the aerial parts of three L. alba specimens by hydrodistillation and analyzed by gas chromatography coupled to a mass spectrometer. Minimum Inhibitory Concentrations (MIC and Minimum Bacterial Concentration (MBC were determined by the microdilution method. For the antibiofilm assays, the biomass formation in the biofilm was evaluated by the microtiter-plate technique with the crystal violet (CV assay and the viability of the bacterial cells was analyzed. All oils and their major components presented antibacterial activity, and the lowest MIC and MBC values were 0.5 mg mL−1 when LA1EO and citral were used. Potential inhibition (100% of S. aureus biofilm formation at the concentration of 0.5 mg mL−1 of all EOs was observed. However, the elimination of biofilm cells was confirmed at concentrations of 1 mg mL−1, 2 mg mL−1, 2 mg mL−1, and 0.5 mg mL−1 for LA1EO, LA2EO, LA3EO, and citral, respectively. The results obtained in the present research point to the promising antibacterial and antibiofilm potential of L. alba EOs against S. aureus, a species of recognized clinical interest.

  18. Antioxidant Activities of Basella alba Aqueous Leave Extract In Blood, Pancreas, and Gonadal Tissues of Diabetic Male Wistar Rats.

    Science.gov (United States)

    Arokoyo, Dennis Seyi; Oyeyipo, Ibukun Peter; Du Plessis, Stefan Simon; Aboua, Yapo Guillaume

    2018-01-01

    Oxidative stress is frequently identified as a key element in the pathophysiology of many complications of diabetes mellitus, including reproductive complications. The antioxidant potential of medicinal plants have been suggested for therapeutic focus of diseases in recent reports. To investigate the effect of Basella alba (Ba) aqueous leave extract on diabetes-induced oxidative stress. Forty male Wistar rats (8-10 weeks) were randomly divided into four groups ( n = 10) and treated as follows; Control (C + Ns) and Diabetic (D + Ns) animals received oral normal saline 0.5 ml/100 g body weight daily, while Healthy Treatment (H + Ba) and Diabetic Treatment (D + Ba) rats were given Ba extract at an oral dose of 200 mg/kg body weight daily. Treatment was by gavage and lasted 4 weeks in all groups. Diabetes was induced in D + Ns and D + Ba rats by single intraperitoneal injection of streptozotocin (55 mg/kg) and fasting blood sugar (FBS) recorded weekly in all rats afterwards. Animals were euthanized at the end of the experiment and blood samples, pancreas, testes, and epididymis were preserved for analysis of oxidative stress biomarkers. Oral administration of aqueous leave extract of Ba significantly ( P antioxidant power, but lower serum concentration of conjugated dienes and thiobarbituric acid reactive substances in D + Ba compared to D + Ns rats ( P antioxidant effects in the gonads by enhancing antioxidant parameters in circulating blood, but not necessarily in the gonadal tissues. Oral treatment of diabetic rats with aqueous leave extract of Basella alba exerts antioxidant effects in the gonads by enhancing antioxidant parameters in circulating blood, but not necessarily in the gonadal tissues. Abbreviations Used: AP - Antioxidant parameters, Ba - Basella alba , CAT - Catalase, CDs - Conjugated dienes, DM - Diabetes mellitus, FBS - Fasting blood sugar, FRAP - Ferric reducing antioxidant power, GSH - reduced glutathione, Ns - Normal saline, ORAC - oxygen radical

  19. Participation of the GABAergic system in the anesthetic effect of Lippia alba (Mill.) N.E. Brown essential oil

    Energy Technology Data Exchange (ETDEWEB)

    Heldwein, C.G.; Silva, L.L. [Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, Santa Maria, RS (Brazil); Reckziegel, P. [Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, Santa Maria, RS (Brazil); Barros, F.M.C. [Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, Santa Maria, RS (Brazil); Bürger, M.E.; Baldisserotto, B. [Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, Santa Maria, RS (Brazil); Mallmann, C.A. [Departamento de Medicina Veterinária Preventiva, Universidade Federal de Santa Maria, Santa Maria, RS (Brazil); Schmidt, D.; Caron, B.O. [Departamento de Ciências Agronômicas e Ambientais, Universidade Federal de Santa Maria, Campus de Frederico Westphalen, Frederico Westphalen, RS (Brazil); Heinzmann, B.M. [Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, Santa Maria, RS (Brazil)

    2012-04-05

    The objective of this study was to identify the possible involvement of the GABAergic system in the anesthetic effect of Lippia alba essential oil (EO). We propose a new animal model using silver catfish (Rhamdia quelen) exposed to an anesthetic bath to study the mechanism of action of EO. To observe the induction and potentiation of the anesthetic effect of EO, juvenile silver catfish (9.30 ± 1.85 g; 10.15 ± 0.95 cm; N = 6) were exposed to various concentrations of L. alba EO in the presence or absence of diazepam [an agonist of high-affinity binding sites for benzodiazepinic (BDZ) sites coupled to the GABA{sub A} receptor complex]. In another experiment, fish (N = 6) were initially anesthetized with the EO and then transferred to an anesthetic-free aquarium containing flumazenil (a selective antagonist of binding sites for BDZ coupled to the GABA{sub A} receptor complex) or water to assess recovery time from the anesthesia. In this case, flumazenil was used to observe the involvement of the GABA-BDZ receptor in the EO mechanism of action. The results showed that diazepam potentiates the anesthetic effect of EO at all concentrations tested. Fish exposed to diazepam and EO showed faster recovery from anesthesia when flumazenil was added to the recovery bath (12.0 ± 0.3 and 7.2 ± 0.7, respectively) than those exposed to water (9.2 ± 0.2 and 3.5 ± 0.3, respectively). In conclusion, the results demonstrated the involvement of the GABAergic system in the anesthetic effect of L. alba EO on silver catfish.

  20. Morusinol extracted from Morus alba inhibits arterial thrombosis and modulates platelet activation for the treatment of cardiovascular disease.

    Science.gov (United States)

    Lee, Jung-Jin; Yang, Hyun; Yoo, Yeong-Min; Hong, Seong Su; Lee, Dongho; Lee, Hyun-Jung; Lee, Hak-Ju; Myung, Chang-Seon; Choi, Kyung-Chul; Jeung, Eui-Bae

    2012-01-01

    Morus alba (white mulberry) has been used in traditional Chinese medicine as an anti-headache, diuretic, expectorant, and anti-diabetic agent. In previous studies, extracts of Morus alba demonstrated favorable biological properties, such as antioxidant activity, suppression of lipoxygenase (LOX)-1, cytotoxicity against cancer cells, and inhibition of the invasion and migration of cancer cells. This study further evaluated the effects of morusinol, a flavonoid derived from Morus alba root bark, on platelet aggregation and thromboxane B(2) (TXB(2) formation in vitro and thrombus formation in vivo. The antiplatelet potential of morusinol was measured using in vitro rabbit platelet aggregation and TXB(2) formation assays. Arterial thrombus formation was investigated using an in vivo ferric chloride (FeCl(3)-induced thrombosis model. Morusinol significantly inhibited collagen- and arachidonic acid-induced platelet aggregation and TXB(2) formation in cultured platelets in a concentration-dependent manner. Thrombus formation was reduced by 32.1, 42.0, and 99.0% for collagen-induced TXB(2) formation, and 8.0, 24.1, and 29.2% for arachadonic acid-induced TXB(2) formation, with 5, 10, and 30 µg/mL morusinol, respectively. Moreover, oral morusinol (20 mg/kg) or aspirin (20 mg/kg) for three days significantly increased the time to occlusion in vivo by 20.3±5.0 or 6.8±2.9 min, respectively, compared with the control (1% CMC, carboxymethyl cellulose). Taken together, these results indicate that morusinol may significantly inhibit arterial thrombosis in vivo due to antiplatelet activity. Thus, morusinol may exert beneficial effects on transient ischemic attacks or stroke via the modulation of platelet activation.

  1. Protective effects of Morus alba leaves extract on ocular functions of pups from diabetic and hypercholesterolemic mother rats.

    Science.gov (United States)

    El-Sayyad, H I H; El-Sherbiny, M A; Sobh, M A; Abou-El-Naga, A M; Ibrahim, M A N; Mousa, S A

    2011-01-01

    Phytotherapy is frequently considered to be less toxic and free from side effects than synthetic drugs. Hence, the present study was designed to investigate the protective use of crude water extract of Morus alba leaves on ocular functions including cataractogenesis, biochemical diabetic and hypercholesterolemic markers, retinal neurotransmitters and retinopathy of rat pups maternally subjected to either diabetes and/or hypercholesterolemia. Application of crude water extract of Morus alba resulted in amelioration of the alterations of maternal serum glucose, LDL, HDL, total cholesterol and creatine phosphokinase activity as well as retinal neurotransmitters including acetylcholine (ACE), adrenaline (AD), nor-adrenaline (NAD), serotonin (5-HT), histamine (HS), dopamine (DA) and gamma amino butyric acid (GABA). The retina of pups of either diabetic and/or hypercholesterolemia mothers exhibited massive alterations of retinal neurotransmitters. The alterations of retinal neurotransmitters were correlated with the observed pathological alterations of retinal pigmented epithelium, photoreceptor inner segment and ganglion cells and increased incidence of DNA fragmentation and apoptosis cell death. However, protection with Morus alba extract led to amelioration of the pathological alterations of retinal neurons and estimated neurotransmitters. Furthermore, a striking incidence of cataract was detected in pups of either diabetic and/or hypercholesterolemic mothers. Highest cataractogenesis was observed in pups of combined -treated groups. Our data indicate that experimental maternal diabetes alone or in combination with hypercholesterolemia led to alteration in the ocular structures of their pups, with an increasing incidence of cataract and retinopathy, and the effects of the extract might be attributed to the hypoglycaemic, antihypercholesterolemic and anti-oxidative potential of flavonoids, the major components of the plant extract.

  2. Fractional CO 2 laser as an effective modality in treatment of striae alba in skin types III and IV

    Directory of Open Access Journals (Sweden)

    Farahnaz Fatemi Naein

    2012-01-01

    Full Text Available Context: Rapid stretching of the skin over the weak connective tissue leads to development of striae distensae. Recently, researchers have shown special interest towards use of fractional photothermolysis in treatment of striae and several studies have shown its usefulness. Our aim was to assess the efficacy of Fractional CO 2 laser in treatment of striae alba. Materials and Methods: A randomized clinical trial was carried out in female patients with striae alba. Ninety two striae were randomly selected and divided into two groups. Five sessions of laser resurfacing, were performed in Group 1, every 2-4 weeks. Group 2 was treated with 10% glycolic acid+0.05% tretinoin cream nightly during the study. Photographs were taken from the striae before and two weeks after the end of treatment. Mean surface area of striae compared between two groups. Patients′ views regarding the degree of improvement were assessed via visual analogue scale (VAS. Results: Forty six striae in Group 1 underwent laser resurfacing and 46 matched striae in Group 2, were treated with topical cream. Mean difference of striae surface area, was significantly decreased after treatment in Group 1 (-37.1±15.6 cm 2 in comparison with Group 2 (-7.9±9 cm 2 (P value >0.001. Mean VAS was significantly higher in Group 1 (3.05±0.74 compared to Group 2 (0.63±0.66 (P value >0.001. Conclusions: Fractional photothermolysis via Fractional CO 2 laser seems to be an effective method for treatment of striae alba.

  3. Composition and antimicrobial activity of essential oils of Artemisia judaica, A. herba-alba and A. arborescens from Libya

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    Janaćković Peđa

    2015-01-01

    Full Text Available The essential oils obtained by hydrodistillation from the aerial parts of Artemisia judaica L., Artemisia herba-alba Asso. and Artemisia arborescens L. (cultivated from Libya, were analyzed by GC and GC-MS. The antimicrobial properties were determined using the broth microdilution method against eight bacterial species: Bacillus cereus (clinical isolate, Micrococcus flavus (ATCC10240, Listeria monocytogenes (NCTC7973, Staphylococcus aureus (ATCC6538, Escherichia coli (ATCC35210, Pseudomonas aeruginosa (ATCC27853, Salmonella typhimurium (ATCC13311, Enterobacter cloacae (human isolates and eight fungal species: Aspergillus niger (ATCC6275, A. ochraceus (ATCC12066, A. versicolor (ATCC11730, A. fumigatus (ATCC1022, Penicillium ochrochloron (ATCC9112, P. funiculosum (ATCC10509, Trichoderma viride (IAM5061 and Candida albicans (human isolate. The major constituents of A. arborescens oil were sesquiterpene hydrocarbons (47.4%. Oxygenated monoterpenes were the dominant constituents in the A. judaica and A. herba-alba oils (54.2% and 77.3%, respectively. Camphor (24.7% and chamazulene (20.9% were the major components in the essential oil of A. arborescens, chrysanthenone (20.8%, cis-chrysanthenyl acetate (17.6% and cis-thujone (13.6% dominated in the A. herba-alba oil, and the major constituents in the A. judaica oil were piperitone (30.21% and cis-chrysanthenol (9.1%. The best antimicrobial activity was obtained for A. judaica oil and the lowest effect was noticed in A. arborescens oil. The effect of the tested oils was higher against Gram (+ than Gram (- bacteria. All three oils showed the best antibacterial activity against Listeria monocytogenes and the lowest against Pseudomonas aeruginosa, Escherichia coli, Enterobacter cloacae, compared to streptomycin and ampicillin. All three oils showed better antifungal activities than ketoconazole, except A. arborescens oil against Aspergillus niger. [Projekat Ministarstv nauke Republike Srbije, br. 173029

  4. Essential oil of Lippia alba and its main constituent citral block the excitability of rat sciatic nerves.

    Science.gov (United States)

    Sousa, D G; Sousa, S D G; Silva, R E R; Silva-Alves, K S; Ferreira-da-Silva, F W; Kerntopf, M R; Menezes, I R A; Leal-Cardoso, J H; Barbosa, R

    2015-08-01

    Lippia alba is empirically used for infusions, teas, macerates, and hydroalcoholic extracts because of its antispasmodic, analgesic, sedative, and anxiolytic effects. Citral is a mixture of trans-geranial and cis-neral and is the main constituent of L. alba essential oil and possesses analgesic, anxiolytic, anticonvulsant, and sedative effects. The present study evaluated the effects of the essential oil of L. alba (EOLa) and citral on compound action potentials (CAPs) in Wistar rat sciatic nerves. Both drugs inhibited CAP in a concentration-dependent manner. The calculated half-maximal inhibitory concentrations (IC50) of peak-to-peak amplitude were 53.2 µg/mL and 35.00 µg/mL (or 230 µM) for EOLa and citral, respectively. Peak-to-peak amplitude of the CAP was significantly reduced by 30 µg/mL EOLa and 10 µg/mL citral. EOLa and citral (at 60 and 30 µg/mL, values close to their respective IC50 for CAP blockade) significantly increased chronaxy and rheobase. The conduction velocity of the first and second CAP components was statistically reduced to ∼86% of control with 10 µg/mL EOLa and ∼90% of control with 3 µg/mL citral. This study showed that EOLa inhibited nerve excitability and this effect can be explained by the presence of citral in its composition. Both EOLa and citral showed inhibitory actions at lower concentrations compared with other essential oils and constituents with local anesthetic activity. In conclusion, these data demonstrate that EOLa and citral are promising agents in the development of new drugs with local anesthetic activity.

  5. Essential oil of Lippia alba and its main constituent citral block the excitability of rat sciatic nerves

    Directory of Open Access Journals (Sweden)

    D.G. Sousa

    2015-08-01

    Full Text Available Lippia alba is empirically used for infusions, teas, macerates, and hydroalcoholic extracts because of its antispasmodic, analgesic, sedative, and anxiolytic effects. Citral is a mixture of trans-geranial and cis-neral and is the main constituent of L. alba essential oil and possesses analgesic, anxiolytic, anticonvulsant, and sedative effects. The present study evaluated the effects of the essential oil of L. alba (EOLa and citral on compound action potentials (CAPs in Wistar rat sciatic nerves. Both drugs inhibited CAP in a concentration-dependent manner. The calculated half-maximal inhibitory concentrations (IC50 of peak-to-peak amplitude were 53.2 µg/mL and 35.00 µg/mL (or 230 µM for EOLa and citral, respectively. Peak-to-peak amplitude of the CAP was significantly reduced by 30 µg/mL EOLa and 10 µg/mL citral. EOLa and citral (at 60 and 30 µg/mL, values close to their respective IC50 for CAP blockade significantly increased chronaxy and rheobase. The conduction velocity of the first and second CAP components was statistically reduced to ∼86% of control with 10 µg/mL EOLa and ∼90% of control with 3 µg/mL citral. This study showed that EOLa inhibited nerve excitability and this effect can be explained by the presence of citral in its composition. Both EOLa and citral showed inhibitory actions at lower concentrations compared with other essential oils and constituents with local anesthetic activity. In conclusion, these data demonstrate that EOLa and citral are promising agents in the development of new drugs with local anesthetic activity.

  6. Participation of the GABAergic system in the anesthetic effect of Lippia alba (Mill.) N.E. Brown essential oil

    International Nuclear Information System (INIS)

    Heldwein, C.G.; Silva, L.L.; Reckziegel, P.; Barros, F.M.C.; Bürger, M.E.; Baldisserotto, B.; Mallmann, C.A.; Schmidt, D.; Caron, B.O.; Heinzmann, B.M.

    2012-01-01

    The objective of this study was to identify the possible involvement of the GABAergic system in the anesthetic effect of Lippia alba essential oil (EO). We propose a new animal model using silver catfish (Rhamdia quelen) exposed to an anesthetic bath to study the mechanism of action of EO. To observe the induction and potentiation of the anesthetic effect of EO, juvenile silver catfish (9.30 ± 1.85 g; 10.15 ± 0.95 cm; N = 6) were exposed to various concentrations of L. alba EO in the presence or absence of diazepam [an agonist of high-affinity binding sites for benzodiazepinic (BDZ) sites coupled to the GABA A receptor complex]. In another experiment, fish (N = 6) were initially anesthetized with the EO and then transferred to an anesthetic-free aquarium containing flumazenil (a selective antagonist of binding sites for BDZ coupled to the GABA A receptor complex) or water to assess recovery time from the anesthesia. In this case, flumazenil was used to observe the involvement of the GABA-BDZ receptor in the EO mechanism of action. The results showed that diazepam potentiates the anesthetic effect of EO at all concentrations tested. Fish exposed to diazepam and EO showed faster recovery from anesthesia when flumazenil was added to the recovery bath (12.0 ± 0.3 and 7.2 ± 0.7, respectively) than those exposed to water (9.2 ± 0.2 and 3.5 ± 0.3, respectively). In conclusion, the results demonstrated the involvement of the GABAergic system in the anesthetic effect of L. alba EO on silver catfish

  7. The SolemnAddress Uttered by Vasile Goldiş in Alba-Iulia on 1 December, 1918

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    Eugen GAGEA

    2011-01-01

    Full Text Available In the report he presented before the Great National Assembly of Alba-Iulia, Vasile Goldişunderlined some of the ideals for which humankind had fought and continued to fight in the postwarperiod: national freedom, social equality. The solemn address he uttered is an expression of hishumanism and confidence in human civilization, of the conviction that the organization of ademocratic state and the achievement of equality of rights for all citizens are and must be a “workof civilization”.

  8. Fruit of Morus nigra and Morus alba as environmental biomonitor. An elemental analysis by k0-instrumental neutron activation analysis

    International Nuclear Information System (INIS)

    Mohammad Wasim; Sajid Iqbal; Sohaila Rahman

    2016-01-01

    In this study, potential of fruit of Morus nigra and Morus alba was evaluated as short-term biomonitor. Each variety of the fruits was collected from 13 different locations of Islamabad with different level of pollution. Both fruits were quantified by k 0 -instrumental neutron activation analysis. Pollution level was assessed by the application of enrichment factor (EF) and principal component analysis (PCA). EF revealed a source of (As, Hg, I and Se) and PCA showed the areas of high dust level. The overall analysis suggested that both fruits could be used as short-term biomonitor. (author)

  9. Caracterização de dezesseis acessos de Lippia alba (Mill) N.E Brown, no Distrito Federal

    OpenAIRE

    Jannuzzi, Hermes

    2006-01-01

    Com o objetivo de identificar o perfil aromático de dezesseis acessos de Lippia alba da coleção da Universidade de Brasília e avaliar o potencial de rendimento desses genótipos, foi conduzido um experimento de campo em latossolo vermelho, sob irrigação por gotejamento, na região do cerrado do Distrito Federal. Foram avaliados os seguintes parâmetros: época de florescimento; habito de crescimento; área foliar; comprimento da haste; massa fresca na colheita (folhas e hastes); massa da folha sec...

  10. Anticoccidial effects of coumestans from Eclipta alba for sustainable control of Eimeria tenella parasitosis in poultry production.

    Science.gov (United States)

    Michels, M G; Bertolini, L C T; Esteves, A F; Moreira, P; Franca, S C

    2011-04-19

    The aim of this study was to evaluate the anticoccidial efficacy of a product containing coumestans from Eclipta alba. Experimental conditions were set up as to reproduce the environment conditions for husbandry adopted in commercial broiler farms. Broilers were raised in broiler chicken shed provided with feeders, drinkers, illumination and temperature control systems and floor covering to afford an adequate nourishing environment. Male Cobb broilers (240) were assigned to four experimental groups being each experimental group set apart in rice straw-covered shed isolated with wire mesh. One-day-old broilers were reared in a coccidian-free environment with ad libitum supply of filtered water and freely available standard feed, from the 1st to the 35th day of life. The T1 group received standard feed (negative control); T2 was treated with standard feed supplemented with 66 ppm of salinomycin (positive control); groups T3 and T4 had standard feed supplemented with the ethyl acetate fraction from methanolic extract of E. alba aerial parts, which contains the coumestans WL and DWL (120 and 180 ppm, respectively). The chicken broilers were individually infected with 2 × 104 oocysts of Eimeria tenella when they were 14 days old and were monitored weekly to evaluate zootechnical parameters such as weight gain and food conversion ratio. Counting of coccidial oocyst in chicken feces was assessed from random samples, from the 21st to 28th days of life, which corresponded to 7-14 days after the infection. Five chickens selected at random from each experimental group were subsequently euthanized at 21, 28 or 35 days of life to determine the lesion score in the cecal region and to excise a cecum portion for histopathological evaluation. The group treated with coumestans from E. alba presented an average weight gain and food conversion ratio higher than the negative control group and similar to the mean value of the positive control group. Coumestan-treated groups showed a

  11. Detection of allergen composition and in vivo immunogenicity of depigmented allergoids of Betula alba.

    Science.gov (United States)

    Carnés, J; Himly, M; Gallego, M; Iraola, V; Robinson, D S; Fernández-Caldas, E; Briza, P

    2009-03-01

    Chemical modification of allergen vaccines to reduce IgE binding improves safety while maintaining clinical efficacy. However, this also complicates the characterization of allergoids using techniques as for native allergen extracts. The objective of this study was to analyse the molecular size of Betula alba depigmented allergoids, conservation of major allergens in the allergoids and in vivo antibody response to immunization. The molecular size of depigmented allergoids was evaluated by high performance-size exclusion chromatography and light scattering techniques. Protein composition was compared with native extracts by capillary liquid chromatography-tandem mass spectrometry based peptide mapping. Rabbits were immunized with depigmented allergoid of Betula pollen adsorbed onto aluminium hydroxide (Depigoid). IgG antibodies against individual allergens were determined by ELISA and immunoblot. Depigmented allergoids contained a range of high molecular weight particles, approximately 60% of which had a molecular weight of 1-3 MDa. Peptide sequencing confirmed the preservation of five isoforms of Bet v 1, as well as Bet v 2, Bet v 6 and Bet v 7. Sera from immunized rabbits showed high levels of specific IgG to rBet v 1.0101 and rBet v 2. The mean protein content was 544+/-106 microg per mg of freeze-dried material for depigmented allergoids and 434+/-71 for native extracts. They retain the capacity to induce specific IgG antibodies against individual allergens present in the native extract. These findings confirm the immunogenicity of depigmented allergoids and may explain why patients treated with these vaccines are protected against the native allergens. Analysis of molecular size and allergen content may be useful techniques for characterization and standardization of allergoid products.

  12. Anti-inflammatory and anti-cancer activity of mulberry (Morus alba L.) root bark

    Science.gov (United States)

    2014-01-01

    Background Root bark of mulberry (Morus alba L.) has been used in herbal medicine as anti-phlogistic, liver protective, kidney protective, hypotensive, diuretic, anti-cough and analgesic agent. However, the anti-cancer activity and the potential anti-cancer mechanisms of mulberry root bark have not been elucidated. We performed in vitro study to investigate whether mulberry root bark extract (MRBE) shows anti-inflammatory and anti-cancer activity. Methods In anti-inflammatory activity, NO was measured using the griess method. iNOS and proteins regulating NF-κB and ERK1/2 signaling were analyzed by Western blot. In anti-cancer activity, cell growth was measured by MTT assay. Cleaved PARP, ATF3 and cyclin D1 were analyzed by Western blot. Results In anti-inflammatory effect, MRBE blocked NO production via suppressing iNOS over-expression in LPS-stimulated RAW264.7 cells. In addition, MRBE inhibited NF-κB activation through p65 nuclear translocation via blocking IκB-α degradation and ERK1/2 activation via its hyper-phosphorylation. In anti-cancer activity, MRBE deos-dependently induced cell growth arrest and apoptosis in human colorectal cancer cells, SW480. MRBE treatment to SW480 cells activated ATF3 expression and down-regulated cyclin D1 level. We also observed that MRBE-induced ATF3 expression was dependent on ROS and GSK3β. Moreover, MRBE-induced cyclin D1 down-regulation was mediated from cyclin D1 proteasomal degradation, which was dependent on ROS. Conclusions These findings suggest that mulberry root bark exerts anti-inflammatory and anti-cancer activity. PMID:24962785

  13. Influence of planting density and nitrogen fertilization on the yield of Morus alba var. tigreada

    International Nuclear Information System (INIS)

    Noda, Yolai; Martín, G. J.

    2014-01-01

    An experiment was carried out to evaluate the effect of planting density (12 500, 25 000 and 37 500 plants/ha) and nitrogen fertilization (100, 300 and 500 kg N/ha/year) on the yield and bromatological composition of Morus alba var. tigreada. The dry matter yield of the total (DMYTB) and edible biomass (DMYEB), and the yield of the leaves (DMYL) and the fresh stems (DMYFS) were measured during two years. The crude fiber (CF) and crude protein (CP) percentages were also calculated. There was interaction of the factors (p < 0,05) in the DMYFS; the highest values were obtained when the maximum planting density was combined with the three doses of N (0,37; 0,35 and 0,32 kg DM/plant), as well as when combining 25 000 plants/ha with 300 and 500 kg N/ha/year (0,27 and 0,34 kg DM/plant, respectively). In the variables DMYTB, DMYEB and DMYL there was no interaction of the studied factors. The highest values of total and edible biomass and leaves were reached with 37 500 plants (4,43; 2,37 and 2,03 kg DM/plant ) and the maximum dose of N (3,16;1,89 and 1,68 kg DM/plant). It is concluded that the best results regarding the yield of mulberry were obtained with the density of 37 500 plants/ha; its combination with the lowest dose of N produced high yields of fresh stems, which constitutes an important component of the biomass consumed by livestock. (author)

  14. Ecological requirements of Abies alba in the French Alps derived from dendro-ecological analysis

    Energy Technology Data Exchange (ETDEWEB)

    Rolland, C.; Michalet, R.; Desplanque, C.; Petetin, A.; Aime, S. [Univ. Joseph Fourier, Grenoble (France). Centre de Biologie Alpine

    1999-06-01

    We used dendro-ecological techniques to investigate fundamental relationships between climate and growth of Abies alba (silver fir) in eastern France. Seven Abies forests in the Trieves region of the French Alps were chosen to represent a wide range of ecological conditions based on the results of previous forest vegetation surveys. In each forest, four trees were sampled in each of five different stands with two cores per tree. These 280 cores were studied using two separate dendro-ecological methods: the pointer years method (based on extreme growth events), and correlation functions between tree ring-widths and monthly climatic data. Data from 11 meteorological stations were combined to provide a regional analysis of precipitation and minimum and maximum temperatures. The two dendro-ecological methods appear to be complementary, as the first technique emphasizes common and low intensity linear correlations between ring-widths and climatic variations, and the second method emphasizes extreme and unusual climatic events such as exceptionally cold or dry years. Across all sites, drought in the previous year was consistently correlated with a low growth rate; however, other climatic variables varied substantially among sites. For example, drought in the current year reduced growth more in the low elevation sites than in the high elevation sites and severe winter frost reduced growth the most in the high altitude sites and the driest site. Moreover, certain growth responses are better correlated with the age of the stands, the canopy closure and the floristic composition of the community than the abiotic factors, emphasizing the value of dendro-ecological sampling based on phytosociological units 63 refs, 4 figs, 1 tab

  15. Diet of the Barn Owl (Tyto alba in Ocoyoacac, Estado de Mexico

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    Alvaro González-Calderón

    2017-10-01

    Full Text Available I studied the feeding habits of the Barn Owl (Tyto alba Strigiformes in Ocoyoacac, State of Mexico (Mexico in 2012. On such occasion, its diet was analyzed based on the description of the mass of undigested parts of preys in 732 pellets collected. For such description I resorted to Margalef, Simpson, Shannon-Wiener and Pielou diversity index showing the diversity of preys on which the Barn Owls fed. Based on Levin’s standardized trophic niche index the food niche breadth was estimated as well as the correlation between pellet dimensions and the number of eaten preys. Small mammals were the most frequent source of food, followed by arthropods and birds. The dominance of small mammals was relatively low (λ = 0.20. Rattus rattus was the species most frequently consumed, followed by four other rodent species associated with an abundant frequency of consumption (Microtus mexicanus, Reithrodontomys microdon, R. megalotis and Peromyscus maniculatus. Shannon-Wiener index value (H’ = 1.85 and Levin’s standardized trophic breadth index (Bst = 0.42 showed a relatively low uniformity and a selective tendency in the consumption of small mammals. The diet of the Barn Owl showed that the consumption of arthropods was relevant, including arachnids. A selective tendency was observed in the consumption of birds. The significant correlations between the dimensions of the pellets with the number of preys consumed were discussed. The results show that the Barn Owl plays an important role in the biological control of native and non-native rodents of the region.

  16. Reduction of the anxiety of medical students after curricular reform Redução da ansiedade de estudantes de medicina após reforma curricular

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    Antonio Waldo Zuardi

    2008-06-01

    Full Text Available OBJECTIVES: Curricular structure may interfere in students' anxiety level at medical schools. The objective of this study was to assess anxiety levels in medical students before and after a curriculum reform at the Medical School of Ribeirão Preto and to compare them with students at other courses that had no curricular changes in the same university campus. METHOD: Study samples were obtained in two moments: 1 two years before the reform; 2 after the reform when the reformed curriculum completed its fourth year. The pre-sample (former curriculum consisted of 307 medical students and 217 students from psychology and biology courses. The post-sample (new curriculum was composed of 330 medical students and 194 students from psychology and biology courses. Anxiety was assessed by the State-Trait Anxiety Inventory (STAI. RESULTS: Comparing the pre with the post sample, we found STAI-T scores of the students under the former curriculum were significantly higher in the first (42.9 + 1.08 and second (41.9 + 1.1 years than the STAI-T scores of the medical students under the new curriculum (38.1 + 1.0 and 37.9 + 1.06, respectively. Students from other courses and 5th year medical students, who followed the same curriculum, did not show any significant differences between different samples. CONCLUSION: These results suggest that changes to medical school curricula may reduce the medical student' levels of anxiety in the first two years of the course.OBJETIVOS: Características da estrutura curricular podem interferir no nível de ansiedade dos alunos do curso médico. O objetivo deste estudo foi avaliar o nível de ansiedade nos alunos do curso médico, antes e depois de uma reforma no currículo da Faculdade de Medicina de Ribeirão Preto, comparando com outros cursos, do mesmo campus da universidade, que não tiveram mudanças curriculares. MÉTODO: As amostras do estudo foram obtidas em dois tempos distintos: 1 dois anos antes da reforma; 2 pós a

  17. Formação profissional ética: um compromisso a partir das diretrizes curriculares? Ethical professional education: a commitment based on the curricular guidelines?

    Directory of Open Access Journals (Sweden)

    Mirelle Finkler

    2010-11-01

    Full Text Available Esta reflexão problematiza o discurso e a prática que se estabelecem em torno do tema da formação ética dos profissionais da saúde e, mais particularmente, do cirurgião-dentista, situando o atual momento de implantação das Diretrizes Curriculares Nacionais no ensino superior brasileiro. Procura-se, desta forma, indicar alguns limites e possibilidades para uma formação ética condizente com o novo perfil profissional almejado.This reflection questions the discourse and practice surrounding the ethical education of health professionals and, more particularly, of dentists, situating the current state of deployment of the National Curriculum Guidelines in Brazilian Higher Education. The goal is to point to a few limits and possibilities for an ethical education in line with the new professional profile that is sought.

  18. Políticas curriculares descentralizadas: autonomia ou recentralização? Decentralized curricular policies: autonomy or re-centralization?

    Directory of Open Access Journals (Sweden)

    José Augusto Pacheco

    2000-12-01

    Full Text Available No período da reforma das décadas de 1980 e 1990, a idéia das políticas curriculares descentralizadas tornou-se central no discurso educacional. O Estado poderá usar o discurso da descentralização para defender mais autonomia e responsabilidade, tal como as forças de mercado poderão empregá-lo para orientar os seus objetivos em relação às escolas. Neste artigo pretendemos identificar uma série de diferentes significados para a palavra descentralização, argumentando que o currículo é um processo intencional e prático em que os principais atores são os professores e os alunos. O ponto central é como caminharmos fora das linhas. A provável resposta introduz a centralidade da escola sem minimizar a importância das questões curriculares.The idea of decentralization became central to educational discourse during the period of reform of the late 1980s and the 1990s. The State can use the discourse of decentralization to argue in favor of greater autonomy and responsibility, just as market forces can use it to attain their objectives in regard to schools. In this article our purpose is to identify a number of different meanings of the term decentralization, arguing that decisions regarding curricula are intentional and practical processes in which students and teachers are the main actors. The key question is how to move ahead off the beaten path. The probable answer will be based on the centrality of the school without minimizing the importance of curriculum-related issues.

  19. Antimicrobial activity of polyphenol-rich fractions from Sida alba L. (Malvaceae) against co-trimoxazol-resistant bacteria strains.

    Science.gov (United States)

    Konaté, Kiessoun; Hilou, Adama; Mavoungou, Jacques François; Lepengué, Alexis Nicaise; Souza, Alain; Barro, Nicolas; Datté, Jacques Y; M'batchi, Bertrand; Nacoulma, Odile Germaine

    2012-02-24

    The increased resistance of microorganisms to the currently used antimicrobials has lead to the evaluation of other agents that might have antimicrobial activity. Medicinal plants are sources of phytochemicals which are able to initiate different biological activities including antimicrobials In vitro antibacterial (MIC, MBC and time-kill studies) of polyphenol-rich fractions from Sida alba L. (Malvaceae) was assessed using ten bacteria strains (Gram-negative and Gram-positive). All test bacteria were susceptible to the polyphenol-rich fractions. Time-kill results showed that after 5 h exposition there was no viable microorganism in the initial inoculum and the effect of polyphenol-rich fractions was faster on Enterococcus faecalis (Gram-positive bacterium) comparatively to the other bacteria strains. The data analysis indicates that the tested of polyphenol-rich fractions has significant effects when compared with the standard antibiotic. These results therefore justify the traditional use of sida alba L., alone or in combination with other herbs to treat bacterial infections.

  20. The fine sand Abra alba community of the Bay of Morlaix twenty years after the Amoco Cadiz oil spill

    Energy Technology Data Exchange (ETDEWEB)

    Dauvin, J.-C. [CNRS-UPRES-A Elico, Wimereux (France). Station Marine de Wimereux

    1998-09-01

    The fine sand Abra alba community from the Bay of Morlaix (western English Channel) was strongly affected by the Amoco Cadiz oil spill of April 1978. The long term changes in the community (1977-1996) show that reconstitution of this community is slow (over 10 yr). A progressive recolonization by amphipod Ampelisca populations constituting the dominant species is observed. The results show that it is necessary to survey the affected communities for a long period of time (> 10 yr) after an event to identify the real ecological impact of an oil spill. The abiotic and biotic factor existing in the Bay of Morlaix are favorable to the establishment and the persistence of stable dominant Ampelisca populations in time. The `climax` concept seems to be applicable to this type of stable environment. The soft-bottom Abra alba community of the Bay of Morlaix may only support a maximal carrying capacity of approximately 10-11 g m{sup -2} (mean annual biomass in decalcified dry weight). The deficit of production during 11 annual cycles may have affected the fish biomass feeding on this community. (author)

  1. The fine sand Abra alba community of the Bay of Morlaix twenty years after the Amoco Cadiz oil spill

    Energy Technology Data Exchange (ETDEWEB)

    Dauvin, J.-C. [CNRS-UPRES-A Elico, Wimereux (France). Station Marine de Wimereux

    1998-09-01

    The fine sand Abra alba community from the Bay of Morlaix (western English Channel) was strongly affected by the Amoco Cadiz oil spill of April 1978. The long term changes in the community (1977-1996) show that reconstitution of this community is slow (over 10 yr). A progressive recolonization by amphipod Ampelisca populations constituting the dominant species is observed. The results show that it is necessary to survey the affected communities for a long period of time (> 10 yr) after an event to identify the real ecological impact of an oil spill. The abiotic and biotic factor existing in the Bay of Morlaix are favorable to the establishment and the persistence of stable dominant Ampelisca populations in time. The 'climax' concept seems to be applicable to this type of stable environment. The soft-bottom Abra alba community of the Bay of Morlaix may only support a maximal carrying capacity ofapproximately 10-11 g m{sup -2} (mean annual biomass in decalcified dry weight). The deficit of production during 11 annual cycles may have affected the fish biomass feeding on this community. (author)

  2. The fine sand Abra alba community of the Bay of Morlaix twenty years after the Amoco Cadiz oil spill

    International Nuclear Information System (INIS)

    Dauvin, J.-C.

    1998-01-01

    The fine sand Abra alba community from the Bay of Morlaix (western English Channel) was strongly affected by the Amoco Cadiz oil spill of April 1978. The long term changes in the community (1977-1996) show that reconstitution of this community is slow (over 10 yr). A progressive recolonization by amphipod Ampelisca populations constituting the dominant species is observed. The results show that it is necessary to survey the affected communities for a long period of time (> 10 yr) after an event to identify the real ecological impact of an oil spill. The abiotic and biotic factor existing in the Bay of Morlaix are favorable to the establishment and the persistence of stable dominant Ampelisca populations in time. The 'climax' concept seems to be applicable to this type of stable environment. The soft-bottom Abra alba community of the Bay of Morlaix may only support a maximal carrying capacity of approximately 10-11 g m -2 (mean annual biomass in decalcified dry weight). The deficit of production during 11 annual cycles may have affected the fish biomass feeding on this community. (author)

  3. Cartilage Protection and Analgesic Activity of a Botanical Composition Comprised of Morus alba, Scutellaria baicalensis, and Acacia catechu

    Directory of Open Access Journals (Sweden)

    Mesfin Yimam

    2017-01-01

    Full Text Available Although there have been augmented advances in drug discovery, current OA management is inadequate due to the lack of successful therapies proven to be effective in modifying disease progression. For some, the risk outweighs the benefit. As a result, there is a desperate need for safe and efficacious natural alternatives. Here we evaluated a composition from Morus alba, Scutellaria baicalensis, and Acacia catechu in maintaining joint structural integrity and alleviating OA associated symptoms in monoiodoacetate- (MIA- induced rat OA disease model. Study lasted for 6 weeks. 59.6%, 64.6%, 70.7%, 69.9%, and 70.3% reductions in pain sensitivity were observed for rats treated with the composition from week 1 to week 5, respectively. Statistically significant improvements in articular cartilage matrix integrity (maintained at 57.1% versus MIA + vehicle treated rats were shown from the modified total Mankin score for animals treated with the composition. The composition showed a statistically significant reduction in uCTX-II level (54.1% reductions. The merit of combining these botanicals was also demonstrated in their synergistic analgesic activity. Therefore, the standardized blend of Morus alba, Scutellaria baicalensis, and Acacia catechu could potentially be considered as an alternative remedy from natural sources for the management of OA and/or its associated symptoms.

  4. Morus alba leaf extract mediates neuroprotection against glyphosate-induced toxicity and biochemical alterations in the brain.

    Science.gov (United States)

    Rebai, Olfa; Belkhir, Manel; Boujelben, Adnen; Fattouch, Sami; Amri, Mohamed

    2017-04-01

    Recent studies demonstrate that glyphosate exposure is associated with oxidative stress and some neurological disorders such as Parkinson's pathology. Therefore, phytochemicals, in particular phenolic compounds, have attracted increasing attention as potential agents for neuroprotection. In the present study, we investigate the impact of glyphosate on the rat brain following i.p. injection and the possible molecular target of neuroprotective activity of the phenolic fraction from Morus alba leaf extract (MALE) and its ability to reduce oxidative damage in the brain. Wistar rats from 180 to 240 g were i.p. treated with a single dose of glyphosate (100 mg kg -1 b.w.) or MALE (100 μg mL -1  kg -1 b.w.) for 2 weeks. Brain homogenates were used to evaluate neurotoxicity induced by the pesticide. For this, biochemical parameters were measured. Data shows that MALE regulated oxidative stress and counteracted glyphosate-induced deleterious effects and oxidative damage in the brain, as it abrogated LDH, protein carbonyls, and malonyldialdehyde. MALE also appears to be able to scavenge H 2 O 2 levels, maintain iron and Ca 2+ homeostasis, and increase SOD activity. Thus, in vivo results showed that mulberry leaf extract is a potent protector against glyphosate-induced toxicity, and its protective effect could result from synergism or antagonism between the various bioactive phenolic compounds in the acetonic fraction from M. alba leaf extract.

  5. Genetic diversity analyses of Lasiodiplodia theobromae on Morus alba and Agave sisalana based on RAPD and ISSR molecular markers

    Directory of Open Access Journals (Sweden)

    Hong-hui Xie

    2016-10-01

    Full Text Available Genetic diversity of 23 Lasiodiplodia theobromae isolates on Morus alba and 6 isolates on Agave sisalana in Guangxi province, China, was studied by using random amplified polymorphic DNA and inter-simple sequence repeat molecular markers. Results of two molecular markers showed that the average percentage of polymorphic loci of all isolates was more than 93%. Both dendrograms of two molecular markers showed obvious relationship between groups and the geographical locations where those strains were collected, among which, the 23 isolates on M. alba were divided into 4 populations and the 6 isolates on A. sisalana were separated as a independent population. The average genetic identity and genetic distance of 5 populations were 0.7215, 0.3284 and 0.7915, 0.2347, respectively, which indicated that the genetic identity was high and the genetic distance was short in the 5 populations. Average value of the gene diversity index (H and the Shannon’s information index (I of 29 isolates were significantly higher than 5 populations which showed that genetic diversity of those isolates was richer than the populations and the degree of genetic differentiation of the isolates was higher. The Gst and Nm of 29 isolates were 0.4411, 0.6335 and 0.4756, 0.5513, respectively, which showed that the genetic diversity was rich in those isolates.

  6. In vitro antifungal activity of four chemotypes of Lippia alba (Verbenaceae essential oils against Alternaria solani (Pleosporeaceae isolates

    Directory of Open Access Journals (Sweden)

    ELISA Z. TOMAZONI

    2016-06-01

    Full Text Available Several volatile natural compounds produced by plant secondary metabolism have been proven to present antimicrobial action, enabling their use in phytopathogen control. They also present low environmental impact when compared to conventional pesticides. Essential oils contain these compounds and can be found in several plant species, such as Lippia alba (Mill. N.E. Brown (Verbenaceae. Essential oils of four chemotypes of L. alba, characterized by their major compounds, namely camphor, citral, linalool and camphor/1,8-cineole, were tested against the phytopathogen Alternaria solani Sorauer (Pleosporaceae, which causes early blight on tomatoes and is responsible for great economic losses regarding production. Essential oils antifungal action was tested in vitro using potato dextrose agar medium with essential oil concentrations at 0.1, 0.5, 1.0, 1.5 and 2.0 µL mL-1. The chemotype that had the best performance was citral, showing significant inhibition compared to the others, starting at the 0.5 µL mL-1 concentration. The essential oil belonging to the linalool chemotype was efficient starting at the 1.5 µL mL-1 concentration. Conversely, the camphor chemotype did not show any action against the phytopathogen. Moreover, the essential oils had no remarkable effect on tomato germination and growth. In conclusion, these essential oils presented fungicidal action against A. solani.

  7. Chemical composition and biological activities of the essential oil from Artemisia herba-alba growing wild in Tunisia.

    Science.gov (United States)

    Amri, Ismail; De Martino, Laura; Marandino, Aurelio; Lamia, Hamrouni; Mohsen, Hanana; Scandolera, Elia; De Feo, Vincenzo; Mancini, Emilia

    2013-03-01

    Aromatic plants can interfere in the Mediterranean ecosystem, mainly by the introduction in the environment of volatile compounds. For this reason, we studied the chemical composition and the possible phytotoxic and antimicrobial activities of the essential oil extracted from leaves of Tunisian Artemisia herba-alba Asso. The chemical composition of the essential oil, obtained by hydrodistillation, was analyzed by GC and GC-MS. In all, 24 compounds were identified. The main components were camphor (39.1%), chrysanthenone (15.0%) and cis-thujone (7.8%). The essential oil was evaluated for its in vitro phytotoxic activity against germination and initial radical growth of Raphanus sativus L., Lepidium sativum L., Sinapis arvensis L., Triticum durum L. and Phalaris canariensis L. seeds. The radicle elongation of the five seeds was affected to different extents by the oil, while germination was not affected. The oil, when tested against eight selected bacterial strains, showed low antimicrobial activity. The chemical composition of the oil of A. herba-alba can help in the chemosystematics of this complex genus. However, the recorded biological activities seem to be neither ecologically nor medicinally significant.

  8. In vitro antifungal activity of four chemotypes of Lippia alba (Verbenaceae) essential oils against Alternaria solani (Pleosporeaceae) isolates.

    Science.gov (United States)

    Tomazoni, Elisa Z; Pansera, Márcia R; Pauletti, Gabriel F; Moura, Sidnei; Ribeiro, Rute T S; Schwambach, Joséli

    2016-05-31

    Several volatile natural compounds produced by plant secondary metabolism have been proven to present antimicrobial action, enabling their use in phytopathogen control. They also present low environmental impact when compared to conventional pesticides. Essential oils contain these compounds and can be found in several plant species, such as Lippia alba (Mill.) N.E. Brown (Verbenaceae). Essential oils of four chemotypes of L. alba, characterized by their major compounds, namely camphor, citral, linalool and camphor/1,8-cineole, were tested against the phytopathogen Alternaria solani Sorauer (Pleosporaceae), which causes early blight on tomatoes and is responsible for great economic losses regarding production. Essential oils antifungal action was tested in vitro using potato dextrose agar medium with essential oil concentrations at 0.1, 0.5, 1.0, 1.5 and 2.0 µL mL-1. The chemotype that had the best performance was citral, showing significant inhibition compared to the others, starting at the 0.5 µL mL-1 concentration. The essential oil belonging to the linalool chemotype was efficient starting at the 1.5 µL mL-1 concentration. Conversely, the camphor chemotype did not show any action against the phytopathogen. Moreover, the essential oils had no remarkable effect on tomato germination and growth. In conclusion, these essential oils presented fungicidal action against A. solani.

  9. Drivers of Dashboard Development (3-D): A Curricular Continuous Quality Improvement Approach.

    Science.gov (United States)

    Shroyer, A Laurie; Lu, Wei-Hsin; Chandran, Latha

    2016-04-01

    Undergraduate medical education (UME) programs are seeking systematic ways to monitor and manage their educational performance metrics and document their achievement of external goals (e.g., Liaison Committee on Medical Education [LCME] accreditation requirements) and internal objectives (institution-specific metrics). In other continuous quality improvement (CQI) settings, summary dashboard reports have been used to evaluate and improve performance. The Stony Brook University School of Medicine UME leadership team developed and implemented summary dashboard performance reports in 2009 to document LCME standards/criteria compliance, evaluate medical student performance, and identify progress in attaining institutional curricular goals and objectives. Key performance indicators (KPIs) and benchmarks were established and have been routinely monitored as part of the novel Drivers of Dashboard Development (3-D) approach to curricular CQI. The systematic 3-D approach has had positive CQI impacts. Substantial improvements over time have been documented in KPIs including timeliness of clerkship grades, midclerkship feedback, student mistreatment policy awareness, and student satisfaction. Stakeholder feedback indicates that the dashboards have provided useful information guiding data-driven curricular changes, such as integrating clinician-scientists as lecturers in basic science courses to clarify the clinical relevance of specific topics. Gaining stakeholder acceptance of the 3-D approach required clear communication of preestablished targets and annual meetings with department leaders and course/clerkship directors. The 3-D approach may be considered by UME programs as a template for providing faculty and leadership with a CQI framework to establish shared goals, document compliance, report accomplishments, enrich communications, facilitate decisions, and improve performance.

  10. Using Medical Students to Enhance Curricular Integration of Cross-Cultural Content

    Directory of Open Access Journals (Sweden)

    Helen M. Shields

    2009-09-01

    Full Text Available We hypothesized that an interested medical student group would be helpful in reviewing tutorial cases and giving relevant feedback on the curricular integration of cross-cultural content using case triggers in a preclinical gastrointestinal pathophysiology course. Self-selected student leaders (n = 9 reviewed pre-existing problem-based learning tutorial cases (n = 3 with cross-cultural triggers, and provided narrative feedback to course faculty. The cases were modified and used for the entire class in the following 2 years. Participating course students' comments and teaching faculty feedback were also noted. Outcomes were a change in case content, student global evaluations of the course, and self-reported faculty comfort with teaching the cases. All three tutorial cases were reviewed by a separate group of 2–3 students. Major and minor revisions were made to each case based on the student feedback. These cases were used in 2007 and 2008 and were the major change to the course during that time. Overall course evaluation scores improved significantly from 2006 to 2008 (p = 0.000. Tutors (n = 22 in 2007; n = 23 in 2008 expressed relief during tutor meetings that students had reviewed the cases. A general framework for eliciting student feedback on problem-based cases was developed. Student feedback, consisting of self-selected students' case reviews and solicited course and tutor comments, added value to a curricular reform to improve the integration of cross-cultural content into a problem-based learning curriculum. Our study underscores the fundamental link between teachers and students as partners in curricular development.

  11. PCN - CONHECIMENTOS DE QUÍMICA, UM OLHAR SOBRE AS ORIENTAÇÕES CURRICULARES OFICIAIS.

    Directory of Open Access Journals (Sweden)

    Albino Oliveira Nunes

    2008-03-01

    Full Text Available Os Parâmetros Curriculares Nacionais para o Ensino Médio foram elaborados para guiar a prática docente rumo a uma reforma educacional pretendida para o modelo brasileiro em consonância com a Lei de Diretrizes e Bases da Educação Brasileira (LDB, 1996. Esse documento foi elaborado por especialistas das diversas áreas a pedido do Ministério da Educação, processo distinto do desejado que seria a construção em processo democrático onde os professores tivessem a possibilidade de produzir um documento que orientaria a direção de suas práticas pedagógicas, onde o docente se sentiria como co-participante do processo. Além disso, há que se levar em consideração a adequação deste documento quanto ao objetivo de orientar a (reconstrução curricular. Notadamente na secção PCN – Conhecimentos de Química, este documento apresenta insuficiências significativas para o seu propósito, tais como: superficialidade, discurso autoritário, etc. Contudo, o PCN – Ciências da Natureza, Matemática e suas Tecnologias, pode ser visto como um marco, uma vez que fomenta o debate sobre a reestruturação curricular do ensino de ciências e matemática em nosso país.

  12. Investigation of the Chemical Changes from Crude and Processed Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma Herbal Pair Extracts by Using Q Exactive High-Performance Benchtop Quadrupole-Orbitrap LC-MS/MS

    Directory of Open Access Journals (Sweden)

    Gang Cao

    2014-01-01

    Full Text Available The Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma herbal pair is mainly used for regulating the functions of liver and spleen, benefiting qi, and nourishing blood. However, the bioactive compounds for the pharmacological activities of the crude and processed Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma herbal pair extracts are still unclear to date. In the present study, Q Exactive high-performance benchtop quadrupole-Orbitrap LC-MS/MS was applied to identify the complicated components from crude and processed Paeoniae Radix Alba, crude and processed Atractylodis Macrocephalae Rhizoma, and their crude and processed herbal pair extracts. 123 and 101 compounds were identified in crude and processed Paeoniae Radix Alba samples, respectively. Meanwhile, 32 and 26 compounds were identified in crude and processed Atractylodis Macrocephalae Rhizoma samples, respectively. In the crude and processed Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma herbal pair extracts, co-decoction could significantly change the chemical composition of Paeoniae Radix Alba and Atractylodis Macrocephalae Rhizoma in solution. The developed method may provide a scientific foundation for deeply elucidating the processing and compatibility mechanism of Paeoniae Radix Alba and Atractylodis Macrocephalae Rhizoma.

  13. Participación de los y las docentes en la transformación curricular

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    Rojas Madrigal, Carolina

    2012-02-01

    Full Text Available Resumen: Este ensayo fue elaborado a partir del enlace de dos momentos: el primero, relacionado con la experiencia de la autora como docente universitaria, y como integrante y coordinadora de la Comisión de Currículum, de la Escuela de Trabajo Social, de la Universidad de Costa Rica. El segundo, propiciado por la reflexión sobre estas prácticas en un grupo de estudio sobre diseño curricular en el Centro de Evaluación Académica de la misma Universidad. Tener el espacio para conjugar experiencia y reflexión permitió retomar labores esenciales que las y los docentes pueden realizar para transformar el currículum, si se parte de una comprensión compleja, histórica y contextual de este. Se concluye, en este sentido, que el diseño y desarrollo curricular son dos momentos inseparables, donde el cuerpo docente puede tener una participación activa y crítica. El análisis realizado, fuertemente imbricado al referente de la propia práctica, se concreta en una propuesta de acciones posibles, cuya viabilidad aumenta si el profesorado cuenta con la formación necesaria, y con una actitud permanente de autocrítica y reflexión.Abstract: This essay was elaborated by the combination of two different moments; the first one related with the experience of the author in his labor as a university educator, and as a integrant and coordinator of the Curriculum Commission of the Social Work School at the University of Costa Rica. The second, based on this practices, propitiated by the reflections emanated from a group of study on curricular design, in the Center of Academic Evaluation of this University. Given this space for combine experience with reflection, permitted to retake essential labors that the docents can do to transform the curriculum, if it parts of a complex contextual and historic understanding of it. It’s concludes that in this sense, the curricular development and design, are two inseparable moments on who the docents can have an

  14. Inovação curricular no ensino superior: entrevista com Marcos Tarciso Masetto

    OpenAIRE

    Masetto, Marcos Tarciso; Nonato, Bréscia; Medeiros, Zulmira

    2017-01-01

    A temática da melhoria na qualidade da formação pedagógica dos docentes de ensino superior sempre foi para ele um problema de pesquisa, mas, há aproximadamente doze anos, Masetto tem se dedicado a um novo tema: a inovação no ensino superior. Masetto coordena na PUC- SP o grupo de pesquisa Formação de Professores e Paradigmas Curriculares (FORPEC)3, que tem como objetivo central “investigar a relação entre formação de professores e currículos inovadores no ensino superior”. Nesta entrevista, o...

  15. Developing successful extra curricular programs for the K-12 grades: Interfacing scientists with schools

    Science.gov (United States)

    Chandrasekhar, Meera

    2000-09-01

    Early familiarity is regarded as one of the keys to attracting female students to traditionally male professions. I will describe four different extra curricular programs that my collaborators in the local school district and I have developed for students in grades 5-12. These programs are part of a project entitled "Promoting Young Women in the Physical sciences", which also includes teacher training and programs in which parents participate with the child. Through these sustained and broad-based interventions, we provide early experiences that we expect will prove positive to students. I will also address the successes and difficulties in starting and sustaining these programs.

  16. Implementación de estrategias curriculares en asignaturas de segundo año de la Licenciatura en Enfermería Implementation of curricular strategies in Nursing 2nd year subjects

    Directory of Open Access Journals (Sweden)

    María Cristina Pérez Guerrero

    2013-04-01

    Full Text Available Se presenta una revisión bibliográfica en la que se valora la implementación de las estrategias curriculares en la Licenciatura en Enfermería, a partir de las asignaturas impartidas en el segundo año de la carrera. Se destaca la importancia de estos recursos pedagógicos en la formación de los estudiantes, su desarrollo y contribución a la solución de situaciones relacionadas con el cuidado, la calidad de la atención de salud, la disminución de eventos adversos y la seguridad del paciente. Las estrategias curriculares vinculadas a la carrera de Enfermería constituyen una forma particular de desarrollar el proceso docente, caracterizadas por una direccionalidad coordinada que responde al perfil de salida del egresado, en la que se imbrican los contenidos y métodos teóricos y prácticos de las unidades curriculares correspondientes al plan de estudio, a partir de una estructura metodológica que garantiza su funcionamiento. Ello contribuye a la formación integral de un profesional competente.A bibliographic revision is presented in order to assess the implementation of curricular strategies in Nursing 2nd year subjects. The importance of teaching aids in students' training, their development and contribution to solve issues related to care and quality of the health system, the lowering of adverse events and the patient´s safety are pointed out. Curricular strategies related to Nursing represent a particular way to develop the teaching process, characterized by a coordinated direction which responds to the graduate's experience, in which theoretical and practical methods and contents of the curricular units that belong to the syllabus are interwoven, starting from a methodological structure that ensures these strategy functions. It contributes to the comprehensive formation of a competent professional.

  17. La pertinencia curricular: un estudio en tres programas universitarios A pertinência curricular: um estudo em três programas universitários Curriculum Relevance: A Study of Three University Programs

    Directory of Open Access Journals (Sweden)

    Luis Alberto Malagón-Plata

    2009-03-01

    Full Text Available Se presenta un estudio de experiencias curriculares de tres programas académicos de la Universidad de Antioquia, Colombia, en las que se buscan elementos para analizar e interpretar los desarrollos sobre pertinencia curricular. Los programas académicos seleccionados para el referente empírico son: Trabajo Social, Ingeniería Sanitaria y Nutrición y Dietética. El eje nodal de este trabajo se centra en lo relacionado con la construcción de un concepto de pertinencia y con el objetivo de identificar y caracterizar las dinámicas de pertinencia relacionadas con los programas en mención.Neste artigo é apresentado um estudo sobre experiências curriculares de três programas acadêmicos da Universidad de Antioquia, Colômbia, nas que são procurados elementos para analisar e interpretar os desenvolvimentos na pertinência curricular. Os programas acadêmicos selecionados para o referente empírico são Trabalho social, Engenheira sanitária e Nutrição e dietética. O eixo nodal deste trabalho relaciona-se com a construção de um conceito de pertinência e com o objetivo de identificar e caracterizar as dinâmicas de pertinência relacionadas com os programas mencionados.The article describes a study of the curricular experiences of three academic programs at the Universidad de Antioquia in Colombia. Elements of these programs are singled out to analyze and interpret the development of curricular relevance. The academic programs selected for the empirical reference are: Social Work, Sanitary Engineering and Nutrition and Diet. The crux of this study centers on aspects related to building a concept of relevance, and the objective is to identify and characterize the dynamics of relevance related to the programs in question.

  18. Maintenance of water uptake and reduced water loss contribute to water stress tolerance of Spiraea alba Du Roi and Spiraea tomentosa L.

    Science.gov (United States)

    Stanton, Kelly M; Mickelbart, Michael V

    2014-01-01

    Two primarily eastern US native shrubs, Spiraea alba Du Roi and Spiraea tomentosa L., are typically found growing in wet areas, often with standing water. Both species have potential for use in the landscape, but little is known of their environmental requirements, including their adaptation to water stress. Two geographic accessions of each species were evaluated for their response to water stress under greenhouse conditions. Above-ground biomass, water relations and gas exchange were measured in well-watered and water stress treatments. In both species, water stress resulted in reduced growth, transpiration and pre-dawn water potential. However, both species also exhibited the ability to osmotically adjust to lower soil water content, resulting in maintained midday leaf turgor potential in all accessions. Net CO2 assimilation was reduced only in one accession of S. alba, primarily due to large reductions in stomatal conductance. S. tomentosa lost a larger proportion of leaves than S. alba in response to water stress. The primary water stress tolerance strategies of S. alba and S. tomentosa appear to be the maintenance of water uptake and reduced water loss.

  19. Pollen percentage thresholds of Abies alba based on 13-year annual records of pollen deposition in modified Tauber traps: perspectives of application to fossil situations

    Czech Academy of Sciences Publication Activity Database

    Pidek, I. A.; Svitavská-Svobodová, Helena; van der Knaap, W. O.; Magyari, E.

    2013-01-01

    Roč. 195, Aug. 16 (2013), s. 26-36 ISSN 0034-6667 Grant - others:European Commission(XE) FP7/2007-2013/ERCno.278065 Institutional support: RVO:67985939 Keywords : Abiers alba * percentage treshold value * pollen Tauber traps Subject RIV: EF - Botanics Impact factor: 1.656, year: 2013

  20. The 2″-O-glucosylation of vitexin and isovitexin in petals of Silene alba is catalysed by two different enzymes

    NARCIS (Netherlands)

    Heinsbroek, R.; Brederode, J. van; Nigtevecht, G. van; Maas, J.; Kamsteeg, J.; Besson, E.; Chopin, J.

    1980-01-01

    Two separate genes, Fg and Vg, which govern the presence of isovitexin 2″-O-glucoside and vitexin 2″-O-glucoside respectively in the petals of Silene alba control different glucosyltransferases. In Vg/Vg,fg/fg plants no isovitexin 2″-O-glucosyltransferase was present and in vg/vg,Fg/Fg plants no