Sample records for akutt lymfatisk leukemi
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Akutt lymfatisk leukemi hos barn i Norge 1992-2000
DEFF Research Database (Denmark)
Kolmannskog, Svein; Flaegstad, Trond; Helgestad, Jon
2007-01-01
BACKGROUND: Acute lymphoblastic leukemia is the most common malignancy in childhood. The survival rate has increased steadily over the last 40 years. MATERIAL AND METHODS: All children aged 0-15 years and diagnosed in Norway in the period 1992-2000, were included in the study (n = 301......). The patients were followed up until 1.1. 2005. RESULTS AND INTERPRETATION: The diagnosis was made in 301 children, 33 new cases per year (range 24 to 40) on average. The peak incidence was between 2 and 5 years. Four of 6 infants with acute lymphoblastic leukemia and all 4 with mature B-cell leukemia are alive....... Two of the remaining 291 children died before treatment was started. 289 were all treated according to the common Nordic NOPHO-ALL 1992 protocol. All children achieved remission (99.7%), except for one who died before remission was achieved. 55 children (19%) relapsed. Radiation to the brain as part...
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Kosten van allogene stamceltransplantaties
M. van Agthoven (Michel); M.T. Groot (Martijn); C.A. Uyl-de Groot (Carin)
2001-01-01
textabstractAllogene stamceltransplantatie is een topspecialistische procedure die met succes kan worden ingezet in de behandeling van (hematologische) maligniteiten, met name bij leukemie. Van oudsher worden transplantaten van verwante donoren gebruikt, maar met de mogelijkheden om transplantaten
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DEFF Research Database (Denmark)
Pedersen, Birgith; Koktved, Dorte Pallesen; Nielsen, Lene Lyngø
Baggrund Patienter, der får strålebehandling eller kemoterapi, oplever et utal af akutte og kroniske bivirkninger. Litteraturen viser, at manglende information og vejledning om forventede bivirkninger skaber angst og utryghed. Informationen og vejledningen skal variere over tid, skabe overblik ...
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DEFF Research Database (Denmark)
Davydow, Dimitry; Ribe, Anette Riisgaard; Pedersen, Henrik Søndergaard
2015-01-01
Antallet af akutte indlæggelser for kroniske sygdomme har i de senere år været stigende i den vestlige verden. De mange indlæggelser har medført øgede udgifter i sundhedsvæsenet, selvom nogle af disse indlæggelser potentielt kunne være undgået med forebyggelse og behandling i det nære sundhedsvæs...
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Utforming og gjennomføring av norsk humanitær hjelp etter opprøret i Ungarn, 1956-1957
Olsen, Heidi Cecilie Vekony
2016-01-01
Denne masteroppgaven tar for seg Norges humanitære hjelp under Ungarnkrisen fra 1956 til 1957. Revolusjonen og den påfølgende flyktningkrisen ga opphav til en akutt nødsituasjon sentralt i Europa. Oppgaven beskriver hvordan norske myndigheter og norske hjelpeorganisasjoner, med fokus på Norges Røde Kors, planla og organiserte hjelpearbeidet, både i nærområdene og etter hvert også i Norge. Oppgaven argumenterer for at norske myndigheters reaksjon på Ungarnkrisen var et tidlig uttrykk for den f...
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Akutte hospitalsindlæggelser fra plejehjem
DEFF Research Database (Denmark)
Raahede, A.; Waldorff, F.B.
2015-01-01
Acute hospital admissions from nursing homes Nursing home residents are frail patients who experience frequent hospital admission with an increased risk for acute confusion, iatrogenic adverse events, nosocomial infections, decline in ADL and death during hospitalization. Avoidance of unnecessary...
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Magnetische velden van hoogspanningslijnen en leukemie bij kinderen
Plas M van der; Houthuijs DJM; Dusseldorp A; Pennders RMJ; Pruppers MJM; LSO
2001-01-01
In response to the conclusion of the Health Council of the Netherlands that 'there is a reasonably consistent association between the occurrence of leukaemia in children and residence near overhead power lines' the Ministry of Housing, Spatial Planning and the Environment (VROM) requested RIVM to
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Behandling av akutt hjerteinfarkt : Trombolyse versus PCI
Grut, Harald
2007-01-01
ABSTRACT Title: Treatment of acute myocardial infarction: Trombolysis versus PCI Background: Acute myocardial infarction is a frequent cause of mortality and morbidity in Norway and other Western countries. The main objective was to examine which treatment would give the best result in the case of an acute myocardial infarction, trombolysis or PCI, considering both mortality and morbidity. I also wanted to compare PCI to facilitated PCI and prehospital trombolysis. Methods: This ...
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Gener efter behandling af almindeligt forekommende akutte øjenlidelser
DEFF Research Database (Denmark)
Krogsgaard, M R; Danborg, L; Jensen, P
1990-01-01
The aim of the study was to determine the duration of symptoms in patients treated in the emergency room at Glostrup Hospital for acute eye-trouble. Nine common diagnoses were selected for the study. All patients seen during a 2 1/2 month period were asked to complete a questionnaire one week aft...
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Chronische lymfatische leukemie: hoog tijd voor een op het risico afgestemd beleid
Kater, A. P.; van Oers, M. H. J.
2003-01-01
B cell chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is wrongly considered to be an indolent disease: even patients with Binet stage A can have disease-related morbidity, necessitating treatment in about 50% of them, and over 25% of these patients will die
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Demyeliniserende sygdom hos børn med akutte neurologiske symptomer
DEFF Research Database (Denmark)
Olofsson, Isa Amalie; Skov, Liselotte; Miranda, Maria Jose
2015-01-01
Demyelinating diseases in children is a broad group of illnesses, which affect the central nervous system. Demyelinating diseases can be monophasic or chronic and comprise acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, multiple sclerosis and neuromyelitis optica...
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Ambulanceservice til patienter med akutte hjertelidelser i Danmark - en status
DEFF Research Database (Denmark)
Lybecker, H; Larsen, C F; Nielsen, J R
1990-01-01
In 1985, the Danish Board of Health published a review of the therapeutic value of heart ambulances. A report is presented here concerning the extent to which prehospital treatment of cardiac arrest recommended by the Board of Health has been intensified after publication of the review. The preho......In 1985, the Danish Board of Health published a review of the therapeutic value of heart ambulances. A report is presented here concerning the extent to which prehospital treatment of cardiac arrest recommended by the Board of Health has been intensified after publication of the review...
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Demyeliniserende sygdom hos børn med akutte neurologiske symptomer
DEFF Research Database (Denmark)
Olofsson, Isa Amalie; Skov, Liselotte; Miranda, Maria Jose
2015-01-01
Demyelinating diseases in children is a broad group of illnesses, which affect the central nervous system. Demyelinating diseases can be monophasic or chronic and comprise acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, multiple sclerosis and neuromyelitis optica. Demye...
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Eosinofil akut lymfatisk leukæmi hos yngre mand hjemvendt fra rejse i troperne
DEFF Research Database (Denmark)
Larsen, Mette Vang; Karstoft, Kristian; Andersen, Mette Klarskov
2011-01-01
A 22-year-old man presented with severe back pain and 60% eosinophilia after returning from the tropics. An extensive investigation for parasitic diseases was negative. Over time, his haemoglobin level and thrombocyte count fell, and the spleen and several lymph nodes were enlarged. The patient w...
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DEFF Research Database (Denmark)
Hansen Bruun, Inge; Schiøttz-Christensen, Berit; Nørgaard, Birgitte
artikel, idet funktionsevnevurdering ikke er en defineret søgeterm (MeSH). 2) En systematisk søgning med en bred søgeprofil opbygget over: a) Patientgruppe: Indlagte ældre; b) Lokalitet: Korttidsafsnit/Akutafdeling, c) Indsats: Funktionsevnevurdering. Søgningen omfattede 5 faser: 1) Søgning i Pub...
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Akutte dødsfald ved tvangsfastholdelse af svært hyperaktive personer
DEFF Research Database (Denmark)
Leth, Peter Mygind; Thomsen, Jørgen Lange
2012-01-01
må henføres til et syndrom som betegnes excited delirium syndrome (EDS), en akut indsættende tilstand karakteriseret ved en hyperaktiv og voldelig adfærd, næsten overmenneskelig styrke og immunitet for smerte. Obduktion viser ikke forandringer som kan forklare dødsfaldet. Årsagen til EDS er ukendt...
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DEFF Research Database (Denmark)
Nikolajsen, Lone; Haroutiunian, Simon
2013-01-01
Based on 19 studies (7,238 participants) a Cochrane review concludes that the addition of caffeine to an analgesic drug provides superior analgesia compared with the analgesic drug alone. The benefit is small, with a number needed to treat of approx. 16. The use of analgesics containing caffeine...... is associated with an increased risk of the development of physical dependence, overuse headache, and withdrawal symptoms upon abrupt discontinuation. Combination analgesics with caffeine should only be used temporarily and exclusively for the treatment of acute pain conditions....
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DEFF Research Database (Denmark)
Sundstrøm, Terje; Wester, Knut; Enger, Martine
2013-01-01
BACKGROUND In 2000, the Scandinavian Neurotrauma Committee (SNC) published evidence-based guidelines for the management of minimal, mild or moderate head injuries. Since then, considerable new evidence has emerged on the clinical use of these guidelines and on the radiation risks associated with ...... patients and for mild head injury patients with medium to high risk. An updated information sheet on head injuries has also been compiled for patients and their relatives.CONCLUSION The SNC recommends the implementation of these guidelines in Norway....
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Bosutinib in the management of chronic myelogenous leukemia
Directory of Open Access Journals (Sweden)
Keller-von Amsberg G
2013-05-01
Full Text Available Gunhild Keller-von Amsberg, Philippe SchafhausenDepartment of Hematology and Oncology and, Stem Cell Transplantation and Pulmonology Division, Oncological Center, University Hospital Hamburg-Eppendorf, Hamburg, GermanyAbstract: Bosutinib (SKI-606 is an orally available, once-daily dual Src and Abl kinase inhibitor, approved by the US Food and Drug Administration for the treatment of adults with chronic, accelerated, or blast-phase Philadelphia chromosome-positive chronic myelogenous leukemia who are intolerant of or resistant to first- or second-generation tyrosine kinase inhibitors. Bosutinib effectively overcomes the majority of imatinib-resistance-conferring BCR-ABL mutations except V299L and T315I. In the Bosutinib Efficacy and Safety in chronic myeloid LeukemiA (BELA trial, bosutinib attained a faster and deeper molecular response than imatinib in newly diagnosed chronic-phase chronic myelogenous leukemia patients. Treatment-emergent adverse events are usually very manageable. Low grade, mostly self-limiting diarrhea represents the most frequently observed toxicity of bosutinib. Anti-diarrheal drugs, antiemetic agents, and/or fluid replacement should be used to treat these patients. The improved hematological toxicity of bosutinib compared with other tyrosine kinase inhibitors has been ascribed to its minimal activity against platelet-derived growth factor receptor and KIT. In this review, we give an overview on the profile of bosutinib, the clinical potential and treatment-emergent adverse events.Keywords: CML, BCR-ABL, SRC/ABL kinase inhibitor, resistance-conferring mutation
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DEFF Research Database (Denmark)
Gude, Anne-Bolette Jill; Høgberg, Lotte Christine Groth; Pedersen, Michael
2007-01-01
of young women of foreign origin. Activated charcoal was the preferred method of gastric decontamination. In 52% of the cases various discrepancies between discharge codes and actual poisonings were found. There were 5 deaths, 2 of which were from mixed overdoses with benzodiazepines involving...
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Nettfrekvente elektromagnetiske felt og helseeffekter
Directory of Open Access Journals (Sweden)
Karl Gerhard Blaasaas
2009-10-01
Full Text Available I denne artikkelen oppsummeres epidemiologisk kunnskap om mulige helseeffekter etter eksponering for nettfrekvente (50/60 Hz elektromagnetiske felt. Vi har basert oss på et flertall av vitenskapelige arbeider publisert i perioden 2001-2004 og konklusjoner i rapporter og oversiktsartikler fra perioden før 2001. Det er ikke funnet noen etiologisk sammenheng mellom elektromagnetiske felt og kronisk sykdom. Man vet heller ikke sikkert hvilke egenskaper ved de elektromagnetiske feltene som eventuelt kan fremskaffe sykdom. Eventuell latenstid fra eksponering til sykdomsutvikling er også ukjent. Eksponering over 0,4 mT fra kraftlinjer ser ut til å kunne gi en dobling i risikoen for barneleukemi, og basert på metaanalyser kan ikke resultatene avvises som tilfeldige funn. Holdepunktene for en slik sammenheng er likevel begrenset. Ved vokseneksponering har man i enkeltstudier observert risikoøkninger for brystkreft, leukemi, hjernesvulst og amyotrofisk lateralsklerose. Det er også gjort isolerte funn av abort blant kvinner eksponert under graviditeten. For alle disse endepunktene er funnene allikevel ikke tilstrekkelige til å trekke sikre konklusjoner om sammenheng med eksponeringThis review is based on epidemiologic literature in the period 2001-2004 and conclusions in reports and review articles before 2001, regarding power frequency (50/60 Hz electromagnetic fields and health outcomes. Twotimes increased risks for childhood leukaemia have been observed among children exposed to magnetic fields above 0.4 mT from power lines, and based on meta-analyses these results can not be regarded as chance alone. The evidence for an association is however, still limited. Increased risks of breast cancer, leukaemia, braintumor and amyotrophic lateral sclerosis have been observed in isolated studies. Increased risk of spontaneousabortion among women exposed during pregnancy has also been reported. None of the observations for any ofthese endpoints are
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Energy Technology Data Exchange (ETDEWEB)
Joergensen, N.M.; Camus, L.-H.; Larsen, B.; Voegele, G.M.; Spikkerud, C.; Anker-Nilsen, T.; Dijk, J van; Lorentsen, S.-H.; Stabbetorp, O.; Bjoerge, A.; Boitsov, S.; Klungsoeyr, J.
2012-07-01
Contents of environmental damage assessments and monitoring of acute oil spills in the marine environment are outlined. The guideline provides general advice on timing, contents and scope of post spill surveys for documenting biological recovery and food safety.(Author)
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Directory of Open Access Journals (Sweden)
Ingeborg Rossow
2009-10-01
Full Text Available SAMMENDRAGBruk og misbruk av rusmidler øker risikoen for en tidlig død. Blant kroniske alkoholmisbrukere er overdødelighetenpå omkring 2-3, og størst overdødelighet finner vi mht. levercirrhose, kreft i øvre deler av fordøyelseskanalen,selvmord og ulykker. Akutt beruselse har spesielt betydning for ulykkesdødsfall som drukning ogtrafikkulykker. Epidemiologiske studier har vist at moderat alkoholkonsum gir en redusert risiko for hjertekardødelighetsammenliknet med avholdenhet (en J-formet risikokurve. Disse funnene reiser en viktig debattomkring implikasjonene for folkehelse.På aggregert nivå gir en økning i alkoholkonsumet en beskjeden effekt på samlet dødelighet, men for alkoholrelatertesykdommer, ulykker og selvmord ser man betydelige effekter av endringer i gjennomsnittskonsumet.Stoffmisbrukere har en høyere overdødelighet enn alkoholmisbrukere (RR omkring 5-30, og de vanligstedødsårsakene er overdoser, selvmord og ulykker. Bruk og misbruk av alkohol er betydelig mer utbredt i befolkningenenn narkotika, og størstedelen av rusmiddelrelaterte dødsfall kan knyttes til alkohol. Det er imidlertidusikkert om dette gjenspeiles i opinionen og som argument ved politiske beslutninger og ressursallokeringer.Rossow I. Alcohol, drugs and mortality. Nor J Epidemiol 1996; 6 (1: 37-44. ENGLISH SUMMARYUse and abuse of intoxicants increase the risk of premature death. Among chronic alcohol abusers the excessmortality is in the range of 2-3. Tthe highest excess mortality is found with respect to liver cirrhosis, cancer inthe upper digestive tract, suicide and accidents. Acute intoxication also increases the risk of premature death,particularly drowning and traffic accidents. Epidemiological studies have demonstrated a lower risk of deathfrom CHD among light and moderate drinkers as compared to abstainers (the J-shaped curve. These findingshave induced an important debate concerning public health implications. At the aggregate level an
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J. Versluis (Jurjen)
2017-01-01
textabstractThe majority of patients with newly diagnosed acute myeloid leukemia (AML) obtain complete hematological remission (CR) after induction chemotherapy, but the incidence of relapse is considerable despite chemotherapeutic consolidation therapy. Currently, post-remission treatment (PRT) for
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Energy Technology Data Exchange (ETDEWEB)
Kelfkens, G.; Pruppers, M.J.M.
2008-07-01
which individuals can influence a municipality's decision on power line placement. [Dutch] Uit een quick scan van het RIVM onder twaalf gemeenten met hoogspanningslijnen in de provincie Utrecht blijkt dat de helft van deze gemeenten niet op de hoogte is van het VROM-advies voor hoogspanningslijnen. Gemeenten waar de hoogspanningslijnenproblematiek speelt, zijn over het algemeen wil van het beleid op de hoogte. Onder druk van verontruste burgers nemen zij vaak strengere maatregelen dan wordt geadviseerd, bijvoorbeeld door maatregelen voor bestaande situaties te treffen of door een vastgesteld woningbouwplan uit te stellen. Geen van de geinterviewde gemeenten heeft een duidelijk aanspreekpunt om hun inwoners over hoogspanningslijnen te informeren. Internationaal epidemiologisch onderzoek wijst op een mogelijk verhoogd risico op leukemie bij kinderen die in de buurt van bovengrondse hoogspanningslijnen wonen. Eind 2005 heeft VROM een beleidsadvies hierover naar gemeenten, provincies en netbeheerders gestuurd. Het ministerie wil voorkomen dat kinderen in nieuwe situaties langdurig aan magnetische velden van bovengrondse hoogspanningslijnen worden blootgesteld. VROM adviseert daarom in nieuwe situaties een zone bij de hoogspanningslijnen vrij te houden van woningen, scholen en kinderdagverblijven. Het advies richt zich op het opstellen of wijzigen van bestemmingsplannen. Omdat een dergelijke procedure jaren duurt, kan nu, ruim twee jaar nadat het advies is ingevoerd, nog niet worden beoordeeld of het succesvol is. De quick scan vond plaats in opdracht van de VROM-Inspectie Regio Noord-West, die wil achterhalen welke rol het VROM-advies binnen gemeenten speelt en welke invloed burgers op het hoogspanningslijnenbeleid uitoefenen.
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Directory of Open Access Journals (Sweden)
Timo Rahko
1990-08-01
. Sisäosan muodostaa poimuuntunut limakalvo. Limakalvoa ympäröivät sidekudossäikeet ja serosa, sappikäytävän loppuosassa myös lihassäikeistö. Seinämässä havaittiin yksittäisiä valkosoluja ja imusolukasautumia. Poikkeuksellisena anatomisena piirteenä voidaan pitää haimasaarekkeiden esiintymistä sappikäytäväseinämän kudoksissa jopa läheisessä kosketuksessa pintaepiteeliin. Limakalvon epiteelikudos on sekä pinta- että rauhassolukkoa, joka erittää limaa. Epiteelissä tunnistettiin lukuisia kerässoluja huolimatta siitä, että poroille oli suoritettu loishäätö edellisenä syksynä.Studier av gallgången (ductus hepaticus communis hos ren.Abstract in Swedish / Sammandrag: Den gemensamma gallgångens histologi och sekretoriska funktion hos renen har inte tidigare beskrivits. För att klarlägga den makroskopiska byggnaden och topografin av den gemensamma gallgången (ductus hepaticus communis undersöktes dessa i 25 renar. Väggen i 20 gallgånger granskades histologiskt. Undersökningarna visade att ductus pancreaticus mynnar ut i ductus hepaticus communis bildande en gemensam utforselgång till duodenum. Ductus hepaticus communis är c. 2-3 mm i diameter och 3-5 cm lång. Den elastiska gangens vägg är c. 1 mm tjock delvis omgiven av fett- och pankreasvävnad. Gangens vägg består av serosa, bindvävsfibrer och nära mynningen ses muskelfibrer. Insidan av gången är beklädd med en veckad slemhinna. Lymfatisk vävnad och enstaka lymfocyter observeras. Anmärkningsvärt är att pankreasvävnad förekommer i gallgångens vägg och under slemhinnan. Slemhinnans epitel består av yt- och körtelepitel som avsöndrar slem. De globulära leukocyterna var talrika i epitelet trots att renarna avmaskats på hösten.