WorldWideScience

Sample records for akk update improvements

  1. AKK update: Improvements from new theoretical input and experimental data

    Science.gov (United States)

    Albino, S.; Kniehl, B. A.; Kramer, G.

    2008-11-01

    We perform a number of improvements to the previous AKK extraction of fragmentation functions for π, K, p/p¯, KS0 and Λ/Λ¯ particles at next-to-leading order. Inclusive hadron production measurements from pp(p¯) reactions at BRAHMS, CDF, PHENIX and STAR are added to the data sample. We use the charge-sign asymmetry of the produced hadrons in pp reactions to constrain the valence quark fragmentations. Data from ee reactions in regions of smaller x and lower √{s} are added. Hadron mass effects are treated for all observables and, for each particle, the hadron mass used for the description of the ee reaction is fitted. The baryons' fitted masses are found to be only around 1% above their true masses, while the values of the mesons' fitted masses have the correct order of magnitude. Large x resummation is applied in the coefficient functions of the ee reactions, and also in the evolution of the fragmentation functions, which in most cases results in a significant reduction of the minimized χ. To further exploit the data, all published normalization errors are incorporated via a correlation matrix.

  2. AKK Update: Improvements from New Theoretical Input and Experimental Data

    CERN Document Server

    Albino, S; Krämer, G

    2008-01-01

    We perform a number of improvements to the previous AKK extraction of fragmentation functions for $\\pi^\\pm$, $K^\\pm$, $p/\\bar{p}$, $K_S^0$ and $\\Lambda/\\bar{\\Lambda}$ particles at next-to-leading order. Inclusive hadron production measurements from $pp(\\bar{p})$ reactions at BRAHMS, CDF, PHENIX and STAR are added to the data sample. We use the charge-sign asymmetry of the produced hadrons in $pp$ reactions to constrain the valence quark fragmentations. Data from $e^+ e^-$ reactions in regions of smaller $x$ and lower $\\sqrt{s}$ are added. Hadron mass effects are treated for all observables and, for each particle, the hadron mass used for the description of the $e^+ e^-$ reaction is fitted. The baryons' fitted masses are found to be only around 1% above their true masses, while the values of the mesons' fitted masses have the correct order of magnitude. Large $x$ resummation is applied in the coefficient functions of the $e^+ e^-$ reactions, and also in the evolution of the fragmentation functions, which in mo...

  3. AKK update. Improvements from new theoretical input and experimental data

    Energy Technology Data Exchange (ETDEWEB)

    Albino, S.; Kniehl, B.A.; Kramer, G. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik

    2008-06-15

    We perform a number of improvements to the previous AKK extraction of fragmentation functions for {pi}{sup {+-}}, K{sup {+-}}, p/ anti p, K{sup 0}{sub S} and {lambda}/ anti {lambda} particles at next-to-leading order. Inclusive hadron production measurements from pp(anti p) reactions at BRAHMS, CDF, PHENIX and STAR are added to the data sample. We use the charge-sign asymmetry of the produced hadrons in pp reactions to constrain the valence quark fragmentations. Data from e{sup +}e{sup -} reactions in regions of smaller x and lower {radical}(s) are added. Hadron mass effects are treated for all observables and, for each particle, the hadron mass used for the description of the e{sup +}e{sup -} reaction is fitted. The baryons' fitted masses are found to be only around 1% above their true masses, while the values of the mesons' fitted masses have the correct order of magnitude. Large x resummation is applied in the coefficient functions of the e{sup +}e{sup -} reactions, and also in the evolution of the fragmentation functions, which in most cases results in a significant reduction of the minimized {chi}{sub 2}. To further exploit the data, all published normalization errors are incorporated via a correlation matrix. (orig.)

  4. Hur ser egentligen AKK-samspel ut?

    DEFF Research Database (Denmark)

    Pilesjö, Maja Sigurd

    Hur ser egentligen AKK-samspel ut? Interaktionsmönster mellan barn med omfattande kommunikativ och motorisk funktionsnedsättning och deras vardagliga samtalspartners. Hur kan egentligen samspel mellan barn med kommunikationsvårighe- ter gå till och faktiskt också fung- era? Maja Sigurd Pilesjö...

  5. Archaeometric exploration at Akköprü in Ankara

    Directory of Open Access Journals (Sweden)

    Ali Akın Akyol

    2013-01-01

    Full Text Available The archaeometric exploration was conducted by surveying and sampling studies on the stone, and mortar samples from Akköprü in Ankara. Spot salt test and conductometric analysis were applied to get water soluble salt content of stone samples. The aggregate and binder part of the mortars were determined by the analyses of acidic aggregate & binder, aggregate granulometry, thin section optic microscopy and X-ray diffraction. In addition, the physical conditions of the stones were determined by some physical tests. The results of archaeometrical data showed that the constructive stone material was mainly andesite besides ignimbrite and dacite, and the original binder material was lime mortar. The cement content of the binder of mortars reveals the recent interventions on Akköprü. In the light of petrographic studies it was understood that the source of the original constructive raw material reflects the local formation. The high soluble salt content and the bad physical conditions of some stones also showed that they are undergoing a decomposition process of different degrees.

  6. Improving Mantel-Haenszel DIF Estimation through Bayesian Updating

    Science.gov (United States)

    Zwick, Rebecca; Ye, Lei; Isham, Steven

    2012-01-01

    This study demonstrates how the stability of Mantel-Haenszel (MH) DIF (differential item functioning) methods can be improved by integrating information across multiple test administrations using Bayesian updating (BU). The authors conducted a simulation that showed that this approach, which is based on earlier work by Zwick, Thayer, and Lewis,…

  7. An improved optimal elemental method for updating finite element models

    Institute of Scientific and Technical Information of China (English)

    Duan Zhongdong(段忠东); Spencer B.F.; Yan Guirong(闫桂荣); Ou Jinping(欧进萍)

    2004-01-01

    The optimal matrix method and optimal elemental method used to update finite element models may not provide accurate results. This situation occurs when the test modal model is incomplete, as is often the case in practice. An improved optimal elemental method is presented that defines a new objective function, and as a byproduct, circumvents the need for mass normalized modal shapes, which are also not readily available in practice. To solve the group of nonlinear equations created by the improved optimal method, the Lagrange multiplier method and Matlab function fmincon are employed. To deal with actual complex structures,the float-encoding genetic algorithm (FGA) is introduced to enhance the capability of the improved method. Two examples, a 7-degree of freedom (DOF) mass-spring system and a 53-DOF planar frame, respectively, are updated using the improved method.Thc example results demonstrate the advantages of the improved method over existing optimal methods, and show that the genetic algorithm is an effective way to update the models used for actual complex structures.

  8. 78 FR 44627 - HOME Investment Partnerships Program: Improving Performance and Accountability; Updating Property...

    Science.gov (United States)

    2013-07-24

    ... Investment Partnerships Program: Improving Performance and Accountability; Updating Property Standards #0;#0... Program: Improving Performance and Accountability; Updating Property Standards AGENCY: Office of the... enhance accountability by States and units of local government in the use of HOME funds,...

  9. Improving precipitation simulation from updated surface characteristics in South America

    Science.gov (United States)

    Pereira, Gabriel; Silva, Maria Elisa Siqueira; Moraes, Elisabete Caria; Chiquetto, Júlio Barboza; da Silva Cardozo, Francielle

    2016-04-01

    Land use and land cover maps and their physical-chemical and biological properties are important variables in the numerical modeling of Earth systems. In this context, the main objective of this study is to analyze the improvements resulting from the land use and land cover map update in numerical simulations performed using the Regional Climate Model system version 4 (RegCM4), as well as the seasonal variations of physical parameters used by the Biosphere Atmosphere Transfer Scheme (BATS). In general, the update of the South America 2007 land use and land cover map, used by the BATS, improved the simulation of precipitation by 10 %, increasing the mean temporal correlation coefficient, compared to observed data, from 0.84 to 0.92 (significant at p Pantanal wetlands); (3) in the Northeast region of Brazil; (4) in northwestern Paraguay; and (5) in the River Plate Basin, in Argentina. Moreover, the main precipitation differences between sensitivity and control experiments occurred during the rainy months in central-north South America (October to March). These were associated with a displacement in the South Atlantic convergence zone (SACZ) positioning, presenting a spatial pattern of alternated areas with higher and lower precipitation rates. These important differences occur due to the replacement of tropical rainforest for pasture and agriculture and the replacement of agricultural areas for pasture, scrubland, and deciduous forest.

  10. Improving precipitation simulation from updated surface characteristics in South America

    Science.gov (United States)

    Pereira, Gabriel; Silva, Maria Elisa Siqueira; Moraes, Elisabete Caria; Chiquetto, Júlio Barboza; da Silva Cardozo, Francielle

    2017-07-01

    Land use and land cover maps and their physical-chemical and biological properties are important variables in the numerical modeling of Earth systems. In this context, the main objective of this study is to analyze the improvements resulting from the land use and land cover map update in numerical simulations performed using the Regional Climate Model system version 4 (RegCM4), as well as the seasonal variations of physical parameters used by the Biosphere Atmosphere Transfer Scheme (BATS). In general, the update of the South America 2007 land use and land cover map, used by the BATS, improved the simulation of precipitation by 10 %, increasing the mean temporal correlation coefficient, compared to observed data, from 0.84 to 0.92 (significant at p < 0.05, Student's t test). Correspondingly, the simulations performed with adjustments in maximum fractional vegetation cover, in visible and shortwave infrared reflectance, and in the leaf area index, showed a good agreement for maximum and minimum temperature, with values closer to observed data. The changes in physical parameters and land use updating in BATS/RegCM4 reduced overestimation of simulated precipitation from 19 to 7 % (significant at p < 0.05, Student's t test). Regarding evapotranspiration and precipitation, the most significant differences due to land use updating were located (1) in the Amazon deforestation arc; (2) around the Brazil-Bolivia border (in the Brazilian Pantanal wetlands); (3) in the Northeast region of Brazil; (4) in northwestern Paraguay; and (5) in the River Plate Basin, in Argentina. Moreover, the main precipitation differences between sensitivity and control experiments occurred during the rainy months in central-north South America (October to March). These were associated with a displacement in the South Atlantic convergence zone (SACZ) positioning, presenting a spatial pattern of alternated areas with higher and lower precipitation rates. These important differences occur due to the

  11. Does updating improve the methodological and reporting quality of systematic reviews?

    Directory of Open Access Journals (Sweden)

    Hamel Candyce

    2006-06-01

    Full Text Available Abstract Background Systematic reviews (SRs must be of high quality. The purpose of our research was to compare the methodological and reporting quality of original versus updated Cochrane SRs to determine whether updating had improved these two quality dimensions. Methods We identifed updated Cochrane SRs published in issue 4, 2002 of the Cochrane Library. We assessed the updated and original versions of the SRs using two instruments: the 10 item enhanced Overview Quality Assessment Questionnaire (OQAQ, and an 18-item reporting quality checklist and flow chart based upon the Quality of Reporting of Meta-analyses (QUOROM statement. At least two reviewers extracted data and assessed quality. We calculated the percentage (with a 95% confidence interval of 'yes' answers to each question. We calculated mean differences in percentage, 95% confidence intervals and p-values for each of the individual items and the overall methodological quality score of the updated and pre-updated versions using OQAQ. Results We assessed 53 SRs. There was no significant improvement in the global quality score of the OQAQ (mean difference 0.11 (-0.28; 0.70 p = 0.52. Updated reviews showed a significant improvement of 18.9 (7.2; 30.6 p Conclusion The overall quality of Cochrane SRs is fair-to-good. Although reporting quality improved on certain individual items there was no overall improvement seen with updating and methodological quality remained unchanged. Further improvement of quality of reporting is possible. There is room for improvement of methodological quality as well. Authors updating reviews should address identified methodological or reporting weaknesses. We recommend to give full attention to both quality domains when updating SRs.

  12. Updating patient histories every five years may improve screening

    Science.gov (United States)

    In order to maintain accurate family histories from their patients, physicians should get a comprehensive family history by age 30, and then update it every five to 10 years because histories change significantly between ages 30 and 50 years. According t

  13. Improved precision and accuracy for microarrays using updated probe set definitions

    Directory of Open Access Journals (Sweden)

    Larsson Ola

    2007-02-01

    Full Text Available Abstract Background Microarrays enable high throughput detection of transcript expression levels. Different investigators have recently introduced updated probe set definitions to more accurately map probes to our current knowledge of genes and transcripts. Results We demonstrate that updated probe set definitions provide both better precision and accuracy in probe set estimates compared to the original Affymetrix definitions. We show that the improved precision mainly depends on the increased number of probes that are integrated into each probe set, but we also demonstrate an improvement when the same number of probes is used. Conclusion Updated probe set definitions does not only offer expression levels that are more accurately associated to genes and transcripts but also improvements in the estimated transcript expression levels. These results give support for the use of updated probe set definitions for analysis and meta-analysis of microarray data.

  14. Updates

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    China's middle and low textile export situation remains grim. India's ban on cotton exports is to improve the competitiveness of the terminal textiles in the international market. In recent years, India has become the opponent of the Chinese textile exports in the international market, especially in the low-end textiles. India relies on the advantages of raw material and labor cost to continue to erode China's international market share. Though the overall technical level of the domestic textile industry and transport conditions are not as good as China, its current price advantage pose a large threat to China's low-end textile and garment exports.

  15. Menugestuurde biocatering : eindrapport AKK

    NARCIS (Netherlands)

    Soethoudt, J.M.; Snels, J.C.M.A.; Jong, de P.W.G.A.

    2005-01-01

    De focus van het project "Menugestuurde Biocatering" was het realiseren van een zo groot mogelijke omzetgroei van biologische producten in de bedrijfscatering. Hierbij werd voor meerdere productgroepen structurele logistieke en marketing oplossingen gezocht, die afhankelijk waren van de levenscyclus

  16. Trichomonas vaginalis: An Updated Overview Towards Diagnostic Improvement.

    Science.gov (United States)

    Oliveira, Ana S; Ferrão, Ana R; Pereira, Filomena Martins; Martinez-de-Oliveira, José; Palmeira-de-Oliveira, Ana

    2016-01-01

    The protozoan Trichomonas vaginalis (TV) is responsible for trichomonosis, a sexually transmitted disease (STD) with a significant incidence worldwide. This infection is one of the most common non-viral STDs, representing almost 50% of all curable STDs. Trichomonosis has an incidence of 180 million new cases worldwide. Nowadays, the 'gold standard' for TV diagnosis remains the use of in vitro cultures combined with daily visual microscopic evaluations, which is a time-consuming and low sensitive method. Recent diagnostic methodologies include imunocromatographic assays and molecular biology techniques. The use of the latter has improved enormously the sensitivity and specificity of TV diagnosis, despite, however, none being unable to identify the presence of live parasites. By understanding the biology, the pathogenesis, the proteomic profile and its relation with the parasite's virulence mechanisms, new possibilities towards diagnostic techniques can arise. This review covers various important aspects of vaginal trichomonosis from the parasite's biology and virulence to recent improvements in diagnostic techniques and also metabolic and protein discoveries.

  17. Practice improvement, part II: update on patient communication technologies.

    Science.gov (United States)

    Roett, Michelle A; Coleman, Mary Thoesen

    2013-11-01

    Patient portals (ie, secure web-based services for patient health record access) and secure messaging to health care professionals are gaining popularity slowly. Advantages of web portals include timely communication and instruction, access to appointments and other services, and high patient satisfaction. Limitations include inappropriate use, security considerations, organizational costs, and exclusion of patients who are uncomfortable with or unable to use computers. Attention to the organization's strategic plan and office policies, patient and staff expectations, workflow and communication integration, training, marketing, and enrollment can facilitate optimal use of this technology. Other communication technologies that can enhance patient care include automated voice or text reminders and brief electronic communications. Social media provide another method of patient outreach, but privacy and access are concerns. Incorporating telehealthcare (health care provided via telephone or Internet), providing health coaching, and using interactive health communication applications can improve patient knowledge and clinical outcomes and provide social support.

  18. Karina ve Akköy kıyı lagünlerindeki küçük ölçekli balıkçılık

    Directory of Open Access Journals (Sweden)

    M. Hakan Kaykaç

    2015-12-01

    Full Text Available Bu çalışmada, Karina ve Akköy (Arapça, Karaca, Bölme ve Kabahayıt lagünlerinde, küçük ölçekli balıkçılıkta kullanılan av araçlarının teknik yapıları ve etkinliği incelenmiştir. Veriler, 2013-2014 yıllarında sahada yüz yüze yapılan görüşmeler ile toplanmıştır. Bulgulara göre, Karina ve Akköy lagünlerde balık üretiminin büyük bir çoğunluğu, küçük ölçekli av araçları (fanyalı uzatma ağı, pinter ve paragat ile gerçekleşmektedir. Karina’da toplam üretimin %90’ı, Akköy’de ise %50’si bu av araçlarıyla elde edilmektedir. 240 üyesi olan S.S. Doğanbey-Tuzburgazı Su Ürünleri Kooperatifi Karina lagününü, özel bir şirket de Akköy lagününü işletmektedir. Akköy lagününde 5 adet tekne primle çalışırken, Karinada yaklaşık 100 üye 60 tekne ile balıkçılık operasyonları gerçekleştirmektedir. Lagünlerde kullanılan küçük ölçekli av araçlarının teknik yapılarının ve etkinliklerinin belirlenmesi, türe uygun boy seçiciliği ve maksimum sürdürülebilir ürün seviyesinin ayarlanmasına katkı sağlayacaktır.

  19. Improved Quasi-Newton method via PSB update for solving systems of nonlinear equations

    Science.gov (United States)

    Mamat, Mustafa; Dauda, M. K.; Waziri, M. Y.; Ahmad, Fadhilah; Mohamad, Fatma Susilawati

    2016-10-01

    The Newton method has some shortcomings which includes computation of the Jacobian matrix which may be difficult or even impossible to compute and solving the Newton system in every iteration. Also, the common setback with some quasi-Newton methods is that they need to compute and store an n × n matrix at each iteration, this is computationally costly for large scale problems. To overcome such drawbacks, an improved Method for solving systems of nonlinear equations via PSB (Powell-Symmetric-Broyden) update is proposed. In the proposed method, the approximate Jacobian inverse Hk of PSB is updated and its efficiency has improved thereby require low memory storage, hence the main aim of this paper. The preliminary numerical results show that the proposed method is practically efficient when applied on some benchmark problems.

  20. The hadronic vacuum polarization function with O(a)-improved Wilson fermions - an update

    CERN Document Server

    Della Morte, Michele; Horch, Hanno; Jäger, Benjamin; Meyer, Harvey; Wittig, Hartmut

    2016-01-01

    We present an update of our lattice QCD study of the vacuum polarization function using O$(a)$-improved $N_ {\\rm f} =2$ Wilson fermions with increased statistics and a large set of momenta. The resulting points are highly correlated and thus require a correlated fitting procedure. We employ an extended frequentist method to estimate the systematic uncertainties due to the momentum dependence and to the continuum and chiral extrapolations. We present preliminary results of the leading order hadronic contribution of the anomalous magnetic moment of the muon $\\left(a_\\mu^{\\mathrm{HLO}}\\right)$ at the physical point for $u,d,s$ and $c$ valence quarks.

  1. A stochastic model updating strategy-based improved response surface model and advanced Monte Carlo simulation

    Science.gov (United States)

    Zhai, Xue; Fei, Cheng-Wei; Choy, Yat-Sze; Wang, Jian-Jun

    2017-01-01

    To improve the accuracy and efficiency of computation model for complex structures, the stochastic model updating (SMU) strategy was proposed by combining the improved response surface model (IRSM) and the advanced Monte Carlo (MC) method based on experimental static test, prior information and uncertainties. Firstly, the IRSM and its mathematical model were developed with the emphasis on moving least-square method, and the advanced MC simulation method is studied based on Latin hypercube sampling method as well. And then the SMU procedure was presented with experimental static test for complex structure. The SMUs of simply-supported beam and aeroengine stator system (casings) were implemented to validate the proposed IRSM and advanced MC simulation method. The results show that (1) the SMU strategy hold high computational precision and efficiency for the SMUs of complex structural system; (2) the IRSM is demonstrated to be an effective model due to its SMU time is far less than that of traditional response surface method, which is promising to improve the computational speed and accuracy of SMU; (3) the advanced MC method observably decrease the samples from finite element simulations and the elapsed time of SMU. The efforts of this paper provide a promising SMU strategy for complex structure and enrich the theory of model updating.

  2. LANDFIRE 2010—Updates to the national dataset to support improved fire and natural resource management

    Science.gov (United States)

    Nelson, Kurtis J.; Long, Donald G.; Connot, Joel A.

    2016-02-29

    The Landscape Fire and Resource Management Planning Tools (LANDFIRE) 2010 data release provides updated and enhanced vegetation, fuel, and fire regime layers consistently across the United States. The data represent landscape conditions from approximately 2010 and are the latest release in a series of planned updates to maintain currency of LANDFIRE data products. Enhancements to the data products included refinement of urban areas by incorporating the National Land Cover Database 2006 land cover product, refinement of agricultural lands by integrating the National Agriculture Statistics Service 2011 cropland data layer, and improved wetlands delineations using the National Land Cover Database 2006 land cover and the U.S. Fish and Wildlife Service National Wetlands Inventory data. Disturbance layers were generated for years 2008 through 2010 using remotely sensed imagery, polygons representing disturbance events submitted by local organizations, and fire mapping program data such as the Monitoring Trends in Burn Severity perimeters produced by the U.S. Geological Survey and the U.S. Forest Service. Existing vegetation data were updated to account for transitions in disturbed areas and to account for vegetation growth and succession in undisturbed areas. Surface and canopy fuel data were computed from the updated vegetation type, cover, and height and occasionally from potential vegetation. Historical fire frequency and succession classes were also updated. Revised topographic layers were created based on updated elevation data from the National Elevation Dataset. The LANDFIRE program also released a new Web site offering updated content, enhanced usability, and more efficient navigation.

  3. Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell Dysfunction

    Directory of Open Access Journals (Sweden)

    Alessandra Puddu

    2013-01-01

    Full Text Available The primary function of pancreatic beta-cells is to produce and release insulin in response to increment in extracellular glucose concentrations, thus maintaining glucose homeostasis. Deficient beta-cell function can have profound metabolic consequences, leading to the development of hyperglycemia and, ultimately, diabetes mellitus. Therefore, strategies targeting the maintenance of the normal function and protecting pancreatic beta-cells from injury or death might be crucial in the treatment of diabetes. This narrative review will update evidence from the recently identified molecular regulators preserving beta-cell mass and function recovery in order to suggest potential therapeutic targets against diabetes. This review will also highlight the relevance for novel molecular pathways potentially improving beta-cell dysfunction.

  4. Updated cloud physics in a regional atmospheric climate model improves the modelled surface energy balance of Antarctica

    NARCIS (Netherlands)

    van Wessem, J.M.; Reijmer, C.H.; Lenaerts, J.T.M.; van de Berg, W.J.; van den Broeke, M.R.; van Meijgaard, E.

    2014-01-01

    In this study the effects of changes in the physics package of the regional atmospheric climate model RACMO2 on the modelled surface energy balance, nearsurface temperature and wind speed of Antarctica are presented. The physics package update primarily consists of an improved turbulent and radiativ

  5. An Update on Improvements to NiCE Support for RELAP-7

    Energy Technology Data Exchange (ETDEWEB)

    McCaskey, Alex [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wojtowicz, Anna [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Deyton, Jordan H. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Patterson, Taylor C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Billings, Jay Jay [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-01-01

    The Multiphysics Object-Oriented Simulation Environment (MOOSE) is a framework that facilitates the development of applications that rely on finite-element analysis to solve a coupled, nonlinear system of partial differential equations. RELAP-7 represents an update to the venerable RELAP-5 simulator that is built upon this framework and attempts to model the balance-of-plant concerns in a full nuclear plant. This report details the continued support and integration of RELAP-7 and the NEAMS Integrated Computational Environment (NiCE). RELAP-7 is fully supported by the NiCE due to on-going work to tightly integrate NiCE with the MOOSE framework, and subsequently the applications built upon it. NiCE development throughout the first quarter of FY15 has focused on improvements, bug fixes, and feature additions to existing MOOSE-based application support. Specifically, this report will focus on improvements to the NiCE MOOSE Model Builder, the MOOSE application job launcher, and the 3D Nuclear Plant Viewer. This report also includes a comprehensive tutorial that guides RELAP-7 users through the basic NiCE workflow: from input generation and 3D Plant modeling, to massively parallel job launch and post-simulation data visualization.

  6. Insulin Pump Failures: Has There Been an Improvement? Update of a Prospective Observational Study.

    Science.gov (United States)

    Guenego, Agathe; Bouzillé, Guillaume; Breitel, Stéphanie; Esvant, Annabelle; Poirier, Jean-Yves; Bonnet, Fabrice; Guilhem, Isabelle

    2016-12-01

    Insulin pump failures had been assessed in our center by a prospective observational study from 2001 to 2007. The aim of this study was to update our data since 2008 and to determine whether there exist specific risk factors for insulin pump failures. All insulin pump defects were prospectively collected between 2008 and 2013 in a monocentric cohort of 350 new pumps. Clinical consequences were recorded. Brand and model of pumps and type of defects and patients' characteristics (gender, type of diabetes, age at diabetes diagnosis, age at first pump, pump treatment duration, number of previous pumps, and number of previous pump failures) were tested for possible association with insulin pump failure. Malfunctions occurred in 239 (68%) pumps. The incidence rate was 33/100 pump-years. There were 28 (12%) complete failures, 17 (7%) alarms, 83 (35%) mechanical defects, and 105 (44%) minor defects. Survival curves did not differ according to pump brand and model. Hyperglycemia occurred in 2.9% of cases. In multivariate analysis, only patient age less than 40 years at the initiation of pump therapy was associated with higher risk of malfunction (hazard ratio 1.64; 95% confidence interval 1.19-2.24; P = 0.002). Pump malfunctions remain common with modern pumps. We report less complete failures than in our previous study. This could be because of improvement in quality of pumps or to our strategy of systematic screening and replacement in case of mechanical defects.

  7. [The guidelines and other scientific technical instruments for improving, updating and validating the Occupational Physician activities].

    Science.gov (United States)

    Apostoli, P

    2008-01-01

    From 2002 to 2007 the Italian Society of Industrial Medicine and Industrial Hygiene (S.I.M.L.I.I.) produced, in the context of the specific Education and Accreditation Programme for occupational physicians, more than 20 guide lines and consensus document on the most important and controversial themes for our Discipline. These instruments have aimed not only to improve the effectiveness of preventive actions but also to constantly adopt rigorous methodologies based where possible on evidence based medicine procedures. The Italian Occupational physicians agree with guidelines of our Scientific Society, but it appears now to be necessary to critically evaluate our experience, at the light of the new Framework Act for the occupational safety and health "Decreto legislativo 81/08" signed by the President of the Italian Republic on April 9, 2008, which firstly included in a legislative act terms such as technical normative, good practices, guide lines. Another important, mandatory reference, for a Medical Discipline as Occupational Medcine remains, in this debate is, in our Country, the National Program for Guide Lines edited By Italian National Health Institute since 2002 and part of current National System of Guide Lines concerning preparation, dissemination, updating, implementation of guide lines in Medicine. In this paper the main aspects related to different kind of instruments such as guide lines, consensus conference reports, technology assessment, good practices, technical normative, focusing in particular the argument identification, methodology, relationship between different instruments and their production and diffusion, economical and ethical issues and possible conflict of interest.

  8. Pleural mesothelioma: management updates and nursing initiatives to improve patient care

    Directory of Open Access Journals (Sweden)

    Lehto RH

    2014-05-01

    Full Text Available Rebecca H LehtoCollege of Nursing, Michigan State University, East Lansing, MI, USAAbstract: Malignant pleural mesothelioma is a relatively rare but aggressive malignancy that is primarily associated with occupational asbestos exposure. While treatment options for mesothelioma have expanded, the disease carries a poor prognosis, with a median of 8 months to 1 year of survival postdiagnosis. This article synthesizes current disease-management practices, including the diagnostic workup, treatment modalities, emerging therapies, and symptom management, and identifies comprehensive nursing strategies that result in the best care based on updated evidence. Multidisciplinary coordination, palliative care initiation, survivorship, and end-of-life care are discussed. Findings may be applied in clinical environments as a resource to help nurses better understand treatment options and care for patients facing malignant pleural mesothelioma. Recommendations for future research are made to move nursing science forward and to improve patient well-being and health-related quality-of-life outcomes for patients and their family members.Keywords: pleural mesothelioma, cancer, symptom management, evidence-based care

  9. Probiotics can improve the clinical outcomes of hepatic encephalopathy: An update meta-analysis.

    Science.gov (United States)

    Zhao, Li-Na; Yu, Tao; Lan, Shao-Yang; Hou, Jiang-Tao; Zhang, Zheng-Zheng; Wang, Shuang-Shuang; Liu, Feng-Bin

    2015-12-01

    Although the efficacy of probiotics has been extensively studied in hepatic encephalopathy (HE), the results remain controversial. The objective of this study is to identify and update the association between probiotics and HE. Up to December 2014, we searched Medline, Embase, Web of Science, Cochrane CENTRAL, and SinoMed of China for all relevant articles about probiotics and HE. Jadad score was used to evaluate the quality of studies. Pooled relative risk (RR), publication bias and heterogeneity were assessed. Nine studies met the inclusion criteria. Probiotics was associated with improvement of minimal HE and prophylaxis of overt HE [RR 1.52; 95% confidence intervals (95% CI) 1.00-2.33]. Studies with probiotics showed reduction of ammonia concentration [standard mean difference (SMD) -0.32, 95% CI -0.54 to -0.11]. Probiotics could reduce physical and psychosocial sickness impact profile (SIP) score with weight mean difference (WMD) -3.13 (95% CI -4.10 to -2.17) and WMD -3.50 (95% CI -4.91 to -2.08), respectively. Similar result was obtained with total SIP score (WMD -4.83; 95% CI -6.24 to -3.43). Reduction of severe adverse events, defined as minimal HE developing into overt HE, hospitalizations, infections or unrelated emergency room (ER) visits, was observed in HE with probiotics (RR 0.59; 95% CI 0.39-0.90). Our pooled results indicated that probiotics was associated with improvement of minimal HE, prophylaxis of overt HE, and reduction of SIP score and severe adverse events. Large well-designed randomised controlled trials are needed to confirm these results. Copyright © 2015. Published by Elsevier Masson SAS.

  10. Update and Improve Subsection NH –– Alternative Simplified Creep-Fatigue Design Methods

    Energy Technology Data Exchange (ETDEWEB)

    Tai Asayama

    2009-10-26

    This report described the results of investigation on Task 10 of DOE/ASME Materials NGNP/Generation IV Project based on a contract between ASME Standards Technology, LLC (ASME ST-LLC) and Japan Atomic Energy Agency (JAEA). Task 10 is to Update and Improve Subsection NH -- Alternative Simplified Creep-Fatigue Design Methods. Five newly proposed promising creep-fatigue evaluation methods were investigated. Those are (1) modified ductility exhaustion method, (2) strain range separation method, (3) approach for pressure vessel application, (4) hybrid method of time fraction and ductility exhaustion, and (5) simplified model test approach. The outlines of those methods are presented first, and predictability of experimental results of these methods is demonstrated using the creep-fatigue data collected in previous Tasks 3 and 5. All the methods (except the simplified model test approach which is not ready for application) predicted experimental results fairly accurately. On the other hand, predicted creep-fatigue life in long-term regions showed considerable differences among the methodologies. These differences come from the concepts each method is based on. All the new methods investigated in this report have advantages over the currently employed time fraction rule and offer technical insights that should be thought much of in the improvement of creep-fatigue evaluation procedures. The main points of the modified ductility exhaustion method, the strain range separation method, the approach for pressure vessel application and the hybrid method can be reflected in the improvement of the current time fraction rule. The simplified mode test approach would offer a whole new advantage including robustness and simplicity which are definitely attractive but this approach is yet to be validated for implementation at this point. Therefore, this report recommends the following two steps as a course of improvement of NH based on newly proposed creep-fatigue evaluation

  11. A New Strategy to Improve Proactive Route Updates in Mobile Ad Hoc Networks

    Directory of Open Access Journals (Sweden)

    Abolhasan Mehran

    2005-01-01

    Full Text Available This paper presents two new route update strategies for performing proactive route discovery in mobile ad hoc networks (MANETs. The first strategy is referred to as minimum displacement update routing (MDUR. In this strategy, the rate at which route updates are sent into the network is controlled by how often a node changes its location by a required distance. The second strategy is called minimum topology change update (MTCU. In this strategy, the route updating rate is proportional to the level of topology change each node experiences. We implemented MDUR and MTCU on top of the fisheye state routing (FSR protocol and investigated their performance by simulation. The simulations were performed in a number of different scenarios, with varied network mobility, density, traffic, and boundary. Our results indicate that both MDUR and MTCU produce significantly lower levels of control overhead than FSR and achieve higher levels of throughput as the density and the level of traffic in the network are increased.

  12. Badhwar-O'Neill 2011 Galactic Cosmic Ray Model Update and Future Improvements

    Science.gov (United States)

    O'Neill, Pat M.; Kim, Myung-Hee Y.

    2014-01-01

    The Badhwar-O'Neill Galactic Cosmic Ray (GCR) Model based on actual GR measurements is used by deep space mission planners for the certification of micro-electronic systems and the analysis of radiation health risks to astronauts in space missions. The BO GCR Model provides GCR flux in deep space (outside the earth's magnetosphere) for any given time from 1645 to present. The energy spectrum from 50 MeV/n-20 GeV/n is provided for ions from hydrogen to uranium. This work describes the most recent version of the BO GCR model (BO'11). BO'11 determines the GCR flux at a given time applying an empirical time delay function to past sunspot activity. We describe the GCR measurement data used in the BO'11 update - modern data from BESS, PAMELA, CAPRICE, and ACE emphasized for than the older balloon data used for the previous BO model (BO'10). We look at the GCR flux for the last 24 solar minima and show how much greater the flux was for the cycle 24 minimum in 2010. The BO'11 Model uses the traditional, steady-state Fokker-Planck differential equation to account for particle transport in the heliosphere due to diffusion, convection, and adiabatic deceleration. It assumes a radially symmetrical diffusion coefficient derived from magnetic disturbances caused by sunspots carried onward by a constant solar wind. A more complex differential equation is now being tested to account for particle transport in the heliosphere in the next generation BO model. This new model is time-dependent (no longer a steady state model). In the new model, the dynamics and anti-symmetrical features of the actual heliosphere are accounted for so empirical time delay functions will no longer be required. The new model will be capable of simulating the more subtle features of modulation - such as the Sun's polarity and modulation dependence on the gradient and curvature drift. This improvement is expected to significantly improve the fidelity of the BO GCR model. Preliminary results of its

  13. Innovation Policy of the European Union: Concept Strategic Update and Instruments Improvement

    Directory of Open Access Journals (Sweden)

    Belal Hassouna

    2013-01-01

    Full Text Available The article characterizes formation of EU innovation policy and its conceptual update, which has strategic character and is concerned with the social and economic model change, determines differences between EU innovation policy and national politics and the forms of its implementation, detects major changes of EU innovation policy instruments, which were the result of support concept and innovation regulations change.

  14. Road and Street Centerlines, Originally based on TIGER then updated/improved from mulitple sources, Published in 2007, Churchill County, NV.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — as of 2007. It is described as 'Originally based on TIGER then updated/improved from mulitple sources'. Data by this publisher are often provided in State Plane...

  15. Updated cloud physics improve the modelled near surface climate of Antarctica of a regional atmospheric climate model

    Directory of Open Access Journals (Sweden)

    J. M. van Wessem

    2013-07-01

    Full Text Available The physics package of the polar version of the regional atmospheric climate model RACMO2 has been updated from RACMO2.1 to RACMO2.3. The update constitutes, amongst others, the inclusion of a parameterization for cloud ice super-saturation, an improved turbulent and radiative flux scheme and a changed cloud scheme. In this study the effects of these changes on the modelled near-surface climate of Antarctica are presented. Significant biases remain, but overall RACMO2.3 better represents the near-surface climate in terms of the modelled surface energy balance, based on a comparison with > 750 months of data from nine automatic weather stations located in East Antarctica. Especially the representation of the sensible heat flux and net longwave radiative flux has improved with a decrease in biases of up to 40 %. These improvements are mainly caused by the inclusion of ice super-saturation, which has led to more moisture being transported onto the continent, resulting in more and optically thicker clouds and more downward longwave radiation. As a result, modelled surface temperatures have increased and the bias, when compared to 10 m snow temperatures from 64 ice core observations, has decreased from −2.3 K to −1.3 K. The weaker surface temperature inversion consequently improves the representation of the sensible heat flux, whereas wind speed remains unchanged.

  16. Improved optimization algorithm for proximal point-based dictionary updating methods

    Science.gov (United States)

    Zhao, Changchen; Hwang, Wen-Liang; Lin, Chun-Liang; Chen, Weihai

    2016-09-01

    Proximal K-singular value decomposition (PK-SVD) is a dictionary updating algorithm that incorporates proximal point method into K-SVD. The attempt of combining proximal method and K-SVD has achieved promising result in such areas as sparse approximation, image denoising, and image compression. However, the optimization procedure of PK-SVD is complicated and, therefore, limits the algorithm in both theoretical analysis and practical use. This article proposes a simple but effective optimization approach to the formulation of PK-SVD. We cast this formulation as a fitting problem and relax the constraint on the direction of the k'th row in the sparse coefficient matrix. This relaxation strengthens the regularization effect of the proximal point. The proposed algorithm needs fewer steps to implement and further boost the performance of PK-SVD while maintaining the same computational complexity. Experimental results demonstrate that the proposed algorithm outperforms conventional algorithms in reconstruction error, recovery rate, and convergence speed for sparse approximation and achieves better results in image denoising.

  17. Improved meteorology from an updated WRF/CMAQ modeling system with MODIS vegetation and albedo

    Science.gov (United States)

    Realistic vegetation characteristics and phenology from the Moderate Resolution Imaging Spectroradiometer (MODIS) products improve the simulation for the meteorology and air quality modeling system WRF/CMAQ (Weather Research and Forecasting model and Community Multiscale Air Qual...

  18. Improving postoperative pain management in children by providing regular training and an updated pain therapy concept.

    Science.gov (United States)

    Heinrich, M; Mechea, A; Hoffmann, F

    2016-04-01

    In recent years, children's hospitals have increasingly implemented postoperative pain management protocols to reduce postoperative pain and improve patient satisfaction. The effectiveness and long-term sustainability of such protocols have rarely been studied. Therefore, we conducted a prospective intervention study to assess the impact of regular training and improvement of clinical processes on the quality of postoperative pain management. We conducted an initial assessment of the status quo of postoperative pain management (Audit 1) followed by repeated training and improvement of clinical processes (analgesic pocket card, parents' brochure, modification of the patient chart, bimonthly advanced trainings sessions) and a follow-up review after 3 years (Audit 2). We used a data entry form, a patient survey, and an anonymous questionnaire for the nursing staff as measurement tools. Our analysis included a total of 93 and 85 patients in the initial and final audits. The return rates of the nursing staff questionnaire were 83% (Audit 1) and 77% (Audit 2). The training and process improvements resulted in significant improvement in the administration of analgesics for pain requiring treatment, the control of pain measurement after the administration of analgesics and the use of non-pharmacological pain therapies. The patients reported faster administration of analgesics for acute pain and improved pain relief following the intervention. Repeated training and improvement of clinical processes can significantly improve the long-term quality of postoperative pain management in children with a tolerable amount of effort on the part of health care professionals and institutions. © 2015 European Pain Federation - EFIC®

  19. Diabetic kidney disease : a clinical update from Kidney Disease: Improving Global Outcomes

    NARCIS (Netherlands)

    Molitch, Mark E.; Adler, Amanda I.; Flyvbjerg, Allan; Nelson, Robert G.; So, Wing-Yee; Wanner, Christoph; Kasiske, Bertram L.; Wheeler, David C.; de Zeeuw, Dick; Mogensen, Carl E.

    The incidence and prevalence of diabetes mellitus (DM) continue to grow markedly throughout the world, due primarily to the increase in type 2 DM (T2DM). Although improvements in DM and hypertension management have reduced the proportion of diabetic individuals who develop chronic kidney disease

  20. An Update on Improvements to NiCE Support for PROTEUS

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, Andrew [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); McCaskey, Alexander J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Billings, Jay Jay [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-09-01

    The Department of Energy Office of Nuclear Energy s Nuclear Energy Advanced Modeling and Simulation (NEAMS) program has supported the development of the NEAMS Integrated Computational Environment (NiCE), a modeling and simulation workflow environment that provides services and plugins to facilitate tasks such as code execution, model input construction, visualization, and data analysis. This report details the developement of workflows for the reactor core neutronics application, PROTEUS. This advanced neutronics application (primarily developed at Argonne National Laboratory) aims to improve nuclear reactor design and analysis by providing an extensible and massively parallel, finite-element solver for current and advanced reactor fuel neutronics modeling. The integration of PROTEUS-specific tools into NiCE is intended to make the advanced capabilities that PROTEUS provides more accessible to the nuclear energy research and development community. This report will detail the work done to improve existing PROTEUS workflow support in NiCE. We will demonstrate and discuss these improvements, including the development of flexible IO services, an improved interface for input generation, and the addition of advanced Fortran development tools natively in the platform.

  1. An Update on Improvements to NiCE Support for PROTEUS

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, Andrew [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); McCaskey, Alexander J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Billings, Jay Jay [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-09-01

    The Department of Energy Office of Nuclear Energy's Nuclear Energy Advanced Modeling and Simulation (NEAMS) program has supported the development of the NEAMS Integrated Computational Environment (NiCE), a modeling and simulation workflow environment that provides services and plugins to facilitate tasks such as code execution, model input construction, visualization, and data analysis. This report details the development of workflows for the reactor core neutronics application, PROTEUS. This advanced neutronics application (primarily developed at Argonne National Laboratory) aims to improve nuclear reactor design and analysis by providing an extensible and massively parallel, finite-element solver for current and advanced reactor fuel neutronics modeling. The integration of PROTEUS-specific tools into NiCE is intended to make the advanced capabilities that PROTEUS provides more accessible to the nuclear energy research and development community. This report will detail the work done to improve existing PROTEUS workflow support in NiCE. We will demonstrate and discuss these improvements, including the development of flexible IO services, an improved interface for input generation, and the addition of advanced Fortran development tools natively in the platform.

  2. Balance control in aging: improvements in anticipatory postural adjustments and updating of internal models.

    Science.gov (United States)

    Kubicki, Alexandre; Mourey, France; Bonnetblanc, François

    2015-12-07

    Postural stability of older subjects can be estimated during orthostatic equilibrium. However, dynamic equilibrium is also important to investigate risks of fall. It implies different interpretations of measures given by force plates. Same dependant variables (e.g. center of pressure displacement) cannot be interpreted the same ways depending of the type of equilibrium that is investigated. In particular, sways increases during dynamic equilibrium and before movement execution may reflect an improvement of feedforward control.

  3. Swedish emergency department triage and interventions for improved patient flows: a national update

    Directory of Open Access Journals (Sweden)

    Farrokhnia Nasim

    2011-12-01

    Full Text Available Abstract Background In Scandinavia, emergency department triage and patient flow processes, are under development. In Sweden, the triage development has resulted in two new triage scales, the Adaptive Process Triage and the Medical Emergency Triage and Treatment System. Both these scales have logistic components, aiming to improve patient flows. The aim of this study was to report the development and current status of emergency department triage and patient flow processes in Sweden. Methods In 2009 and 2010 the Swedish Council on Health Technology Assessment sent out a questionnaire to the ED managers in all (74 Swedish hospital emergency departments. The questionnaire comprised questions about triage and interventions to improve patient flows. Results Nearly all (97% EDs in Sweden employed a triage scale in 2010, which was an increase from 2009 (73%. Further, the Medical Emergency Triage and Treatment System was the triage scale most commonly implemented across the country. The implementation of flow-related interventions was not as common, but more than half (59% of the EDs have implemented or plan to implement nurse requested X-ray. Conclusions There has been an increase in the use of triage scales in Swedish EDs during the last few years, with acceleration for the past two years. Most EDs have come to use the Medical Emergency Triage and Treatment System, which also indicates regional co-operation. The implementation of different interventions for improved patient flows in EDs most likely is explained by the problem of crowding. Generally, more studies are needed to investigate the economical aspects of these interventions.

  4. [Review of the 2016 Swiss immunization schedule and technology update for improving vaccine management].

    Science.gov (United States)

    Diana, Alessandro

    2016-05-11

    The 2016 immunization schedule published by the Swiss Federal Office of Public Health includes three new clauses: reimbursement of the additional Human Papillomavirus (HPV) vaccination in young males (11-26 years) as recommended by local canton programs, the end of franchise exemption for the measles, mumps and rubella (MMR) vaccination, and the creation of a new system of indemnities and moral compensation in the event of personal injury resulting from vaccinations. This article presents the main features of the 2016 immunization schedule with details of the technology available to physicians to improve vaccine management.

  5. New strategies to improve results of mesh surgeries for vaginal prolapses repair – an update

    Directory of Open Access Journals (Sweden)

    Fernando Goulart Fernandes Dias

    2015-08-01

    Full Text Available ABSTRACTThe use of meshes has become the first option for the treatment of soft tissue disorders as hernias and stress urinary incontinence and widely used in vaginal prolapse's treatment. However, complications related to mesh issues cannot be neglected. Various strategies have been used to improve tissue integration of prosthetic meshes and reduce related complications. The aim of this review is to present the state of art of mesh innovations, presenting the whole arsenal which has been studied worldwide since composite meshes, coated meshes, collagen's derived meshes and tissue engineered prostheses, with focus on its biocompatibility and technical innovations, especially for vaginal prolapse surgery.

  6. Improvement Strategies, Cost Effective Production, and Potential Applications of Fungal Glucose Oxidase (GOD): Current Updates.

    Science.gov (United States)

    Dubey, Manish K; Zehra, Andleeb; Aamir, Mohd; Meena, Mukesh; Ahirwal, Laxmi; Singh, Siddhartha; Shukla, Shruti; Upadhyay, Ram S; Bueno-Mari, Ruben; Bajpai, Vivek K

    2017-01-01

    Fungal glucose oxidase (GOD) is widely employed in the different sectors of food industries for use in baking products, dry egg powder, beverages, and gluconic acid production. GOD also has several other novel applications in chemical, pharmaceutical, textile, and other biotechnological industries. The electrochemical suitability of GOD catalyzed reactions has enabled its successful use in bioelectronic devices, particularly biofuel cells, and biosensors. Other crucial aspects of GOD such as improved feeding efficiency in response to GOD supplemental diet, roles in antimicrobial activities, and enhancing pathogen defense response, thereby providing induced resistance in plants have also been reported. Moreover, the medical science, another emerging branch where GOD was recently reported to induce several apoptosis characteristics as well as cellular senescence by downregulating Klotho gene expression. These widespread applications of GOD have led to increased demand for more extensive research to improve its production, characterization, and enhanced stability to enable long term usages. Currently, GOD is mainly produced and purified from Aspergillus niger and Penicillium species, but the yield is relatively low and the purification process is troublesome. It is practical to build an excellent GOD-producing strain. Therefore, the present review describes innovative methods of enhancing fungal GOD production by using genetic and non-genetic approaches in-depth along with purification techniques. The review also highlights current research progress in the cost effective production of GOD, including key advances, potential applications and limitations. Therefore, there is an extensive need to commercialize these processes by developing and optimizing novel strategies for cost effective GOD production.

  7. Bioavailability Improvement Strategies for Poorly Water-Soluble Drugs Based on the Supersaturation Mechanism: An Update.

    Science.gov (United States)

    Yang, Meiyan; Gong, Wei; Wang, Yuli; Shan, Li; Li, Ying; Gao, Chunsheng

    2016-01-01

    The formulation development for poorly soluble drugs still remains a challenge. Supersaturating drug delivery systems (SDDS) or drug delivery systems based on supersaturating provide a promising way to improve the oral bioavailability of poorly water-soluble drugs. In supersaturable formulations, drug concentration exceeds the equilibrium solubility when exposed to gastrointestinal fluids, and the supersaturation state is maintained long enough to be absorbed, resulting in compromised bioavailability. In this article, the mechanism of generating and maintaining supersaturation and the evaluation methods of supersaturation assays are discussed. Recent advances in different drug delivery systems based on supersaturating are the focus and are discussed in detail.This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

  8. Improvement Strategies, Cost Effective Production, and Potential Applications of Fungal Glucose Oxidase (GOD): Current Updates

    Science.gov (United States)

    Dubey, Manish K.; Zehra, Andleeb; Aamir, Mohd; Meena, Mukesh; Ahirwal, Laxmi; Singh, Siddhartha; Shukla, Shruti; Upadhyay, Ram S.; Bueno-Mari, Ruben; Bajpai, Vivek K.

    2017-01-01

    Fungal glucose oxidase (GOD) is widely employed in the different sectors of food industries for use in baking products, dry egg powder, beverages, and gluconic acid production. GOD also has several other novel applications in chemical, pharmaceutical, textile, and other biotechnological industries. The electrochemical suitability of GOD catalyzed reactions has enabled its successful use in bioelectronic devices, particularly biofuel cells, and biosensors. Other crucial aspects of GOD such as improved feeding efficiency in response to GOD supplemental diet, roles in antimicrobial activities, and enhancing pathogen defense response, thereby providing induced resistance in plants have also been reported. Moreover, the medical science, another emerging branch where GOD was recently reported to induce several apoptosis characteristics as well as cellular senescence by downregulating Klotho gene expression. These widespread applications of GOD have led to increased demand for more extensive research to improve its production, characterization, and enhanced stability to enable long term usages. Currently, GOD is mainly produced and purified from Aspergillus niger and Penicillium species, but the yield is relatively low and the purification process is troublesome. It is practical to build an excellent GOD-producing strain. Therefore, the present review describes innovative methods of enhancing fungal GOD production by using genetic and non-genetic approaches in-depth along with purification techniques. The review also highlights current research progress in the cost effective production of GOD, including key advances, potential applications and limitations. Therefore, there is an extensive need to commercialize these processes by developing and optimizing novel strategies for cost effective GOD production. PMID:28659876

  9. Integrated insulin pump therapy with continuous glucose monitoring for improved adherence: technology update

    Directory of Open Access Journals (Sweden)

    Tumminia A

    2015-09-01

    Full Text Available Andrea Tumminia,1 Laura Sciacca,1 Lucia Frittitta,1 Sebastiano Squatrito,1 Riccardo Vigneri,2 Rosario Le Moli,1 Letizia Tomaselli2 1Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, Catania, Italy; 2Endocrinology, Garibaldi-Nesima Hospital, Catania, Italy Abstract: Insulin pump therapy combined with real-time continuous glucose monitoring, known as sensor-augmented pump (SAP therapy, has been shown to improve metabolic control and to reduce the rate of hypoglycemia in adults with type 1 diabetes compared to multiple daily injections or standard continuous subcutaneous insulin infusion. Glycemic variability is also reduced in patients on SAP therapy. This approach allows patients to monitor their glucose levels being informed of glycemic concentration and trend. Trained diabetic patients, therefore, can appropriately modify insulin infusion and/or carbohydrate intake in order to prevent hypo- or hyperglycemia. For these reasons, SAP therapy is now considered the gold standard for type 1 diabetes treatment. To be clinically effective, however, devices and techniques using advanced technology should not only have the potential to theoretically ameliorate metabolic control, but also be well accepted by patients in terms of satisfaction and health-related quality of life, because these factors will improve treatment adherence and consequently overall outcome. SAP therapy is generally well tolerated by patients; however, many clinical trials have identified significant noncompliance in the use of this device, most notably in the pediatric and adolescent populations. In this review we aim to analyze the main reasons for good or poor adherence to SAP therapy and to provide useful tips in order to fully benefit from this kind of novel therapeutic approach. Keywords: sensor-augmented insulin pump therapy, type 1 diabetes, quality of life, patient adherence, continuous subcutaneous insulin

  10. Improving Semantic Updating Method on 3d City Models Using Hybrid Semantic-Geometric 3d Segmentation Technique

    Science.gov (United States)

    Sharkawi, K.-H.; Abdul-Rahman, A.

    2013-09-01

    to LoD4. The accuracy and structural complexity of the 3D objects increases with the LoD level where LoD0 is the simplest LoD (2.5D; Digital Terrain Model (DTM) + building or roof print) while LoD4 is the most complex LoD (architectural details with interior structures). Semantic information is one of the main components in CityGML and 3D City Models, and provides important information for any analyses. However, more often than not, the semantic information is not available for the 3D city model due to the unstandardized modelling process. One of the examples is where a building is normally generated as one object (without specific feature layers such as Roof, Ground floor, Level 1, Level 2, Block A, Block B, etc). This research attempts to develop a method to improve the semantic data updating process by segmenting the 3D building into simpler parts which will make it easier for the users to select and update the semantic information. The methodology is implemented for 3D buildings in LoD2 where the buildings are generated without architectural details but with distinct roof structures. This paper also introduces hybrid semantic-geometric 3D segmentation method that deals with hierarchical segmentation of a 3D building based on its semantic value and surface characteristics, fitted by one of the predefined primitives. For future work, the segmentation method will be implemented as part of the change detection module that can detect any changes on the 3D buildings, store and retrieve semantic information of the changed structure, automatically updates the 3D models and visualize the results in a userfriendly graphical user interface (GUI).

  11. Improved higher lead time river flow forecasts using sequential neural network with error updating

    Directory of Open Access Journals (Sweden)

    Prakash Om

    2014-03-01

    Full Text Available This paper presents a novel framework to use artificial neural network (ANN for accurate forecasting of river flows at higher lead times. The proposed model, termed as sequential ANN (SANN, is based on the heuristic that a mechanism that provides an accurate representation of physical condition of the basin at the time of forecast, in terms of input information to ANNs at higher lead time, helps improve the forecast accuracy. In SANN, a series of ANNs are connected sequentially to extend the lead time of forecast, each of them taking a forecast value from an immediate preceding network as input. The output of each network is modified by adding an expected value of error so that the residual variance of the forecast series is minimized. The applicability of SANN in hydrological forecasting is illustrated through three case examples: a hypothetical time series, daily river flow forecasting of Kentucky River, USA and hourly river flow forecasting of Kolar River, India. The results demonstrate that SANN is capable of providing accurate forecasts up to 8 steps ahead. A very close fit (>94% efficiency was obtained between computed and observed flows up to 1 hour in advance for all the cases, and the deterioration in fit was not significant as the forecast lead time increased (92% at 8 steps ahead. The results show that SANN performs much better than traditional ANN models in extending the forecast lead time, suggesting that it can be effectively employed in developing flood management measures.

  12. Improving Transparency in the Reporting of Safeguards Implementation: FY11 Update

    Energy Technology Data Exchange (ETDEWEB)

    Toomey, Christopher; Odlaug, Christopher S.; Wyse, Evan T.

    2011-09-30

    In 2008, the Standing Advisory Group on Safeguards Implementation (SAGSI) indicated that the International Atomic Energy Agency's (IAEA) Safeguards Implementation Report (SIR) has not kept pace with the evolution of safeguards and provided the IAEA with a set of recommendations for improvement. The SIR is the primary mechanism for providing an overview of safeguards implementation in a given year and reporting on the annual safeguards findings and conclusions drawn by the Secretariat. As the IAEA transitions to State-level safeguards approaches, SIR reporting must adapt to reflect these evolutionary changes. This evolved report will better reflect the IAEA's transition to a more qualitative and information-driven approach, based upon State-as-a-whole considerations. This paper applies SAGSI's recommendations to the development of multiple models for an evolved SIR and finds that an SIR repurposed as a 'safeguards portal' could significantly enhance information delivery, clarity, and transparency. In addition, this paper finds that the 'portal concept' also appears to have value as a standardized information presentation and analysis platform for use by Country Officers, for continuity of knowledge purposes, and the IAEA Secretariat in the safeguards conclusion process. Accompanying this paper is a fully functional prototype of the 'portal' concept, built using commercial software and IAEA Annual Report data and available for viewing at http://safeguardsportal.pnnl.gov.

  13. Atmospheric emissions of anthropogenic lead in Europe: improvements, updates, historical data and projections

    Energy Technology Data Exchange (ETDEWEB)

    Pacyna, J.M.; Pacyna, E.G.

    2000-07-01

    This report provides estimates of lead emissions to the atmosphere in Europe, discriminated by country and by source category within each country. Estimates of past lead emissions are provided for the years 1955, 1965, 1975, 1985, 1990 and 1995. Estimates for 1955-1990 have been improved relatively to earlier estimates for these years provided in 1996 for IIASA, using recently available data. Predictions of future lead emissions are provided for the year 2010. The methodology of estimating emissions is described. (orig.) [German] Dieser Bericht enthaelt Schaetzungen ueber die nationalen Bleiemissionen der europaeischen Laender in die Atmosphaere. Dabei wurden die verschiedenen Arten von Bleiemissionsquellen differenziert beruecksichtigt. Die Schaetzungen liegen fuer die Jahre 1955, 1965, 1975, 1985, 1990 und 1995 vor. Im Vergleich zu den Berechnungen der IIASA 1996 fuer die Jahre 1955-1990, wurden die Schaetzungen in diesem Bericht aufgrund neuer, aktueller Dateninformationen deutlich verbessert. Vorhersagen fuer die zukuenftigen Bleiemissionen in Europa wurden fuer das Jahr 2010 gechaetzt. Zudem enthaelt der Bericht eine ausfuehrliche Beschreibung ueber die den Schaetzungen zugrunde liegenden Methode. (orig.)

  14. Updated teaching techniques improve CPR performance measures: a cluster randomized, controlled trial.

    Science.gov (United States)

    Ettl, Florian; Testori, Christoph; Weiser, Christoph; Fleischhackl, Sabine; Mayer-Stickler, Monika; Herkner, Harald; Schreiber, Wolfgang; Fleischhackl, Roman

    2011-06-01

    The first-aid training necessary for obtaining a drivers license in Austria has a regulated and predefined curriculum but has been targeted for the implementation of a new course structure with less theoretical input, repetitive training in cardiopulmonary resuscitation (CPR) and structured presentations using innovative media. The standard and a new course design were compared with a prospective, participant- and observer-blinded, cluster-randomized controlled study. Six months after the initial training, we evaluated the confidence of the 66 participants in their skills, CPR effectiveness parameters and correctness of their actions. The median self-confidence was significantly higher in the interventional group [IG, visual analogue scale (VAS:"0" not-confident at all,"100" highly confident):57] than in the control group (CG, VAS:41). The mean chest compression rate in the IG (98/min) was closer to the recommended 100 bpm than in the CG (110/min). The time to the first chest compression (IG:25s, CG:36s) and time to first defibrillator shock (IG:86s, CG:92s) were significantly shorter in the IG. Furthermore, the IG participants were safer in their handling of the defibrillator and started with countermeasures against developing shock more often. The management of an unconscious person and of heavy bleeding did not show a difference between the two groups even after shortening the lecture time. Motivation and self-confidence as well as skill retention after six months were shown to be dependent on the teaching methods and the time for practical training. Courses may be reorganized and content rescheduled, even within predefined curricula, to improve course outcomes. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  15. ACS Updates Environmental Report.

    Science.gov (United States)

    Chemical and Engineering News, 1978

    1978-01-01

    Describes a new publication of a report prepared by the American Chemical Society's Committee on Environmental Improvement. This is a new version that updates a 1969 report and contains additional material and expanded recommendations. (GA)

  16. ACS Updates Environmental Report.

    Science.gov (United States)

    Chemical and Engineering News, 1978

    1978-01-01

    Describes a new publication of a report prepared by the American Chemical Society's Committee on Environmental Improvement. This is a new version that updates a 1969 report and contains additional material and expanded recommendations. (GA)

  17. Improving the efficiency and relevance of evidence-based recommendations in the era of whole-genome sequencing: an EGAPP methods update.

    Science.gov (United States)

    Veenstra, David L; Piper, Margaret; Haddow, James E; Pauker, Stephen G; Klein, Roger; Richards, Carolyn Sue; Tunis, Sean R; Djulbegovic, Benjamin; Marrone, Michael; Lin, Jennifer S; Berg, Alfred O; Calonge, Ned

    2013-01-01

    To provide an update on recent revisions to Evaluation of Genomic Applications in Practice and Prevention (EGAPP) methods designed to improve efficiency, and an assessment of the implications of whole genome sequencing for evidence-based recommendation development. Improvements to the EGAPP approach include automated searches for horizon scanning, a quantitative ranking process for topic prioritization, and the development of a staged evidence review and evaluation process. The staged process entails (i) triaging tests with minimal evidence of clinical validity, (ii) using and updating existing reviews, (iii) evaluating clinical validity prior to analytic validity or clinical utility, (iv) using decision modeling to assess potential clinical utility when direct evidence is not available. EGAPP experience to date suggests the following approaches will be critical for the development of evidence based recommendations in the whole genome sequencing era: (i) use of triage approaches and frameworks to improve efficiency, (ii) development of evidence thresholds that consider the value of further research, (iii) incorporation of patient preferences, and (iv) engagement of diverse stakeholders. The rapid advances in genomics present a significant challenge to traditional evidence based medicine, but also an opportunity for innovative approaches to recommendation development.

  18. Website updates

    Data.gov (United States)

    National Aeronautics and Space Administration — Updates to Website: (Please add new items at the top of this description with the date of the website change) May 9, 2012: Uploaded experimental data in matlab...

  19. Circular Updates

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Circular Updates are periodic sequentially numbered instructions to debriefing staff and observers informing them of changes or additions to scientific and specimen...

  20. Cybersecurity Update

    CERN Document Server

    Heagerty, Denise

    2008-01-01

    An update on recent security issues and vulnerabilities affecting Windows, Linux and Mac platforms. This talk is based on contributions and input from a range of colleagues both within and outside CERN. It covers clients, servers and control systems.

  1. CATL Update

    Science.gov (United States)

    2011-03-24

    2010 Report sent NATC CATL 1922 20K Treadwear Bridgestone 2 LT235/85R16 (L/R E) GMC 2500 (2WD) Awaiting new control tire NATC CATL 1922 20K Treadwear...1 DSCC Annual Tire Conference CATL UPDATE March 24, 2011 UNCLASSIFIED: Dist A. Approved for public release Report Documentation Page...A 3. DATES COVERED - 4. TITLE AND SUBTITLE CATL Update 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d

  2. GASS: The Parkes Galactic All-Sky Survey. Update: improved correction for instrumental effects and new data release

    CERN Document Server

    Kalberla, Peter M W

    2015-01-01

    The Galactic All-Sky Survey is a survey of Galactic atomic hydrogen emission in the southern sky observed with the Parkes 64-m Radio Telescope. The first data release (GASS I) concerned survey goals and observing techniques, the second release (GASS II) focused on stray radiation and instrumental corrections. We seek to remove the remaining instrumental effects and present a third data release. We use the HEALPix tessellation concept to grid the data on the sphere. Individual telescope records are compared with averages on the nearest grid position for significant deviations. All averages are also decomposed into Gaussian components with the aim of segregating unacceptable solutions. Improved priors are used for an iterative baseline fitting and cleaning. In the last step we generate 3-D FITS data cubes and examine them for remaining problems. We have removed weak, but systematic baseline offsets with an improved baseline fitting algorithm. We have unraveled correlator failures that cause time dependent oscil...

  3. Military Personnel: DOD Needs to Update General and Flag Officer Requirements and Improve Availability of Associated Costs

    Science.gov (United States)

    2014-09-01

    costs to support workforce allocation decisions, and have a thorough understanding of the implications of those costs to DOD and, on a broader scale...of GFOs and improve its ability to make sound workforce allocation decisions. View GAO-14-745. For more information, contact Brenda S. Farrell at...D.C.: November 1999); and Federal Accounting Standards Advisory Board, Statement of Federal Financial Accounting Standards No. 4: Managerial Cost

  4. How to improve an un-alterable model forecast? A sequential data assimilation based error updating approach

    Science.gov (United States)

    Gragne, A. S.; Sharma, A.; Mehrotra, R.; Alfredsen, K. T.

    2012-12-01

    Accuracy of reservoir inflow forecasts is instrumental for maximizing value of water resources and influences operation of hydropower reservoirs significantly. Improving hourly reservoir inflow forecasts over a 24 hours lead-time is considered with the day-ahead (Elspot) market of the Nordic exchange market in perspectives. The procedure presented comprises of an error model added on top of an un-alterable constant parameter conceptual model, and a sequential data assimilation routine. The structure of the error model was investigated using freely available software for detecting mathematical relationships in a given dataset (EUREQA) and adopted to contain minimum complexity for computational reasons. As new streamflow data become available the extra information manifested in the discrepancies between measurements and conceptual model outputs are extracted and assimilated into the forecasting system recursively using Sequential Monte Carlo technique. Besides improving forecast skills significantly, the probabilistic inflow forecasts provided by the present approach entrains suitable information for reducing uncertainty in decision making processes related to hydropower systems operation. The potential of the current procedure for improving accuracy of inflow forecasts at lead-times unto 24 hours and its reliability in different seasons of the year will be illustrated and discussed thoroughly.

  5. Updating Nursing Service Notion and Improving Nursing Service Quality%更新护理服务理念提升护理服务品质

    Institute of Scientific and Technical Information of China (English)

    王蕾

    2016-01-01

    In the increasingly fierce competition in the medical market, in order to stand out in the competition and win the market and development, we should not ignore the function of nursing team as one of the indispensable main bodies of hos-pital. Our hospital should update the concept, improve the service awareness, maintain nurse-patient relationship, pay atten-tion to communication skills, enhance train of nurses, improve the quality of nurses, standardize the nursing service behav-ior, deepen nursing service connotation, pay attention to nursing service art, build nursing service atmosphere, strength nursing quality and safety management, advocate “give priority to prevention, put safety first”, improve nursing quality, im-prove nursing connotation quality and create an advantage nursing brand.%在日趋激烈的医疗市场竞争中,如何能够在竞争中脱颖而出,赢得市场和发展,作为医院不可缺少的主体之一的护理团队其作用不可忽视。该院更新观念,提高服务意识,和谐护患关系,注重沟通技巧,加强护士培训,提高护士素质,规范护理服务行为,深化护理服务内涵,注重护理服务艺术,营造护理服务氛围,强化护理质量与安全管理,倡导“预防为主、安全第一”,提高护理品质,提高护理内涵质量,创造优势护理品牌。

  6. GASS: The Parkes Galactic All-Sky Survey. Update: improved correction for instrumental effects and new data release

    Science.gov (United States)

    Kalberla, P. M. W.; Haud, U.

    2015-06-01

    Context. The Galactic All-Sky Survey (GASS) is a survey of Galactic atomic hydrogen (H i) emission in the southern sky observed with the Parkes 64-m Radio Telescope. The first data release (GASS I) concerned survey goals and observing techniques, the second release (GASS II) focused on stray radiation and instrumental corrections. Aims: We seek to remove the remaining instrumental effects and present a third data release. Methods: We use the HEALPix tessellation concept to grid the data on the sphere. Individual telescope records are compared with averages on the nearest grid position for significant deviations. All averages are also decomposed into Gaussian components with the aim of segregating unacceptable solutions. Improved priors are used for an iterative baseline fitting and cleaning. In the last step we generate 3D FITS data cubes and examine them for remaining problems. Results: We have removed weak, but systematic baseline offsets with an improved baseline fitting algorithm. We have unraveled correlator failures that cause time dependent oscillations; errors cause stripes in the scanning direction. The remaining problems from radio frequency interference (RFI) are spotted. Classifying the severeness of instrumental errors for each individual telescope record (dump) allows us to exclude bad data from averages. We derive parameters that allow us to discard dumps without compromising the noise of the resulting data products too much. All steps are reiterated several times: in each case, we check the Gaussian parameters for remaining problems and inspect 3D FITS data cubes visually. We find that in total ~1.5% of the telescope dumps need to be discarded in addition to ~0.5% of the spectral channels that were excluded in GASS II. Conclusions: The new data release (GASS III) facilitates data products with improved quality. A new web interface, compatible with the previous version, is available for download of GASS III FITS cubes and spectra.

  7. Repaglinide/metformin fixed-dose combination to improve glycemic control in patients with type 2 diabetes: an update

    Directory of Open Access Journals (Sweden)

    Robert G Moses

    2010-05-01

    Full Text Available Robert G MosesClinical Trials and Research Unit, South East Sydney and Illawarra Area Health Service, New South Wales, AustraliaAbstract: Type 2 diabetes is a progressive disease associated with high levels of morbidity and mortality and for which there is both a large and growing prevalence worldwide. Lifestyle advice plus metformin is commonly recommended initially to manage hyperglycemia and to minimize the risk of vascular complications. However, additional agents are required when glycemic targets cannot be achieved or maintained due to the progressive nature of the disease. Repaglinide/metformin fixed-dose combination (FDC therapy (PrandiMet®; Novo Nordisk, Bagsværd, Denmark has been approved for use in the USA. This FDC is a rational second-line therapy given the complementary mechanisms of action of the components. Repaglinide is a rapidly absorbed, short-acting insulin secretagogue targeting postprandial glucose excursions; metformin is an insulin sensitizer with a longer duration of action that principally regulates basal glucose levels. A pivotal, 26-week, randomized study with repaglinide/metformin FDC therapy has been conducted in patients experiencing suboptimal control with previous oral antidiabetes therapy. Repaglinide/metformin FDC improved glycemic control and weight neutrality without adverse effects on lipid profiles. There were no major hypoglycemic episodes and patients expressed greater satisfaction with repaglinide/metformin FDC than previous treatments. Repaglinide/metformin FDC is expected to be more convenient than individual tablets for patients taking repaglinide and metformin in loose combination, and it is expected to improve glycemic control in patients for whom meglitinide or metformin monotherapies provide inadequate control.Keywords: type 2 diabetes, metformin, repaglinide, PrandiMet®, fixed-dose combination

  8. Protein energy wasting in chronic kidney disease: An update with focus on nutritional interventions to improve outcomes

    Directory of Open Access Journals (Sweden)

    Yashpal P Jadeja

    2012-01-01

    Full Text Available Protein-energy wasting (PEW is common in patients with chronic kidney disease (CKD. PEW is one of the strongest predictors of mortality in patients with CKD. The International Society of Renal Nutrition and Metabolism (ISRNM expert panel has defined PEW as a, "state of decreased body stores of protein and energy fuels (body protein and fat masses". The ISRNM panel has also proposed diagnostic criteria of PEW with four categories. Cachexia is a severe form of PEW. The proposed causes of PEW are multi-factorial and include nutritional and non-nutritional mechanisms. The literature indicates that PEW can be mitigated or corrected with an appropriate diet and enteral nutritional support that targets dietary protein intake. Dietary requirements and enteral nutritional support must also be considered in patients with CKD and diabetes mellitus and in children with CKD, in addition to dialysis patients. Features of ideal dietary supplement have also been discussed. Dietary interventions such as enteral feeding with high-protein meals or supplements might improve the nutritional status and outcomes in dialysis patients.

  9. Haematological cancers: improving outcomes. A summary of updated NICE service guidance in relation to Specialist Integrated Haematological Malignancy Diagnostic Services (SIHMDS).

    Science.gov (United States)

    Snowden, John A; O'Connell, Susan; Hawkins, James; Dalley, Chris; Jack, Andrew; Mannari, Deepak; McNamara, Chris; Scott, Mike; Shenton, Geoff; Soilleux, Elizabeth; Macbeth, Fergus

    2017-06-01

    Haematological malignancies are a diverse group of cancers that affect the blood, bone marrow and lymphatic systems. Laboratory diagnosis of haematological malignancies is dependent on combining several technologies, including morphology, immunophenotyping, cytogenetics and molecular genetics correlated clinical details and classification according to the current WHO guidelines. The concept of the Specialised Integrated Haematological Malignancy Diagnostic Services (SIHMDS) has evolved since the UK National Institute for Health and Care Excellence (NICE) Improving Outcomes Guidance (IOG) in 2003 and subsequently various models of delivery have been established. As part of the 2016 update to the NICE IOG, these models were systematically evaluated and recommendations produced to form the basis for quality standards for future development of SIHMDS. We provide a summary of the systematic review and recommendations. Although the recommendations pertain to the UK National Health Service (NHS), they have relevance to the modern delivery of diagnostic services internationally. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  10. NXE pellicle: development update

    Science.gov (United States)

    Brouns, Derk; Bendiksen, Aage; Broman, Par; Casimiri, Eric; Colsters, Paul; de Graaf, Dennis; Harrold, Hilary; Hennus, Piet; Janssen, Paul; Kramer, Ronald; Kruizinga, Matthias; Kuntzel, Henk; Lafarre, Raymond; Mancuso, Andrea; Ockwell, David; Smith, Daniel; van de Weg, David; Wiley, Jim

    2016-09-01

    ASML introduced the NXE pellicle concept, a removable pellicle solution that is compatible with current and future patterned mask inspection methods. We will present results of how we have taken the idea from concept to a demonstrated solution enabling the use of EUV pellicle by the industry for high volume manufacturing. We will update on the development of the next generation of pellicle films with higher power capability. Further, we will provide an update on top level requirements for pellicles and external interface requirements needed to support NXE pellicle adoption at a mask shop. Finally, we will present ASML's pellicle handling equipment to enable pellicle use at mask shops and our NXE pellicle roadmap outlining future improvements.

  11. Decentralized Consistent Updates in SDN

    KAUST Repository

    Nguyen, Thanh Dang

    2017-04-10

    We present ez-Segway, a decentralized mechanism to consistently and quickly update the network state while preventing forwarding anomalies (loops and blackholes) and avoiding link congestion. In our design, the centralized SDN controller only pre-computes information needed by the switches during the update execution. This information is distributed to the switches, which use partial knowledge and direct message passing to efficiently realize the update. This separation of concerns has the key benefit of improving update performance as the communication and computation bottlenecks at the controller are removed. Our evaluations via network emulations and large-scale simulations demonstrate the efficiency of ez-Segway, which compared to a centralized approach, improves network update times by up to 45% and 57% at the median and the 99th percentile, respectively. A deployment of a system prototype in a real OpenFlow switch and an implementation in P4 demonstrate the feasibility and low overhead of implementing simple network update functionality within switches.

  12. Age-related differences in strategy knowledge updating: blocked testing produces greater improvements in metacognitive accuracy for younger than older adults.

    Science.gov (United States)

    Price, Jodi; Hertzog, Christopher; Dunlosky, John

    2008-09-01

    Age-related differences in updating knowledge about strategy effectiveness after task experience have not been consistently found, perhaps because the magnitude of observed knowledge updating has been rather meager for both age groups. We examined whether creating homogeneous blocks of recall tests based on two strategies used at encoding (imagery and repetition) would enhance people's learning about strategy effects on recall. Younger and older adults demonstrated greater knowledge updating (as measured by questionnaire ratings of strategy effectiveness and by global judgments of performance) with blocked (versus random) testing. The benefit of blocked testing for absolute accuracy of global predictions was smaller for older than younger adults. However, individual differences in correlations of strategy effectiveness ratings and postdictions showed similar upgrades for both age groups. Older adults learn about imagery's superior effectiveness but do not accurately estimate the magnitude of its benefit, even after blocked testing.

  13. The value of information updating in new product development

    CERN Document Server

    Artmann, Christian

    2009-01-01

    This work shows how managing uncertainty in new product development can be improved by conducting an information update during the development process. The book details the comprehensive model needed to perform that information update.

  14. How to Green Windows Update?

    Directory of Open Access Journals (Sweden)

    Seifedine Kadry

    2012-11-01

    Full Text Available The most important challenges facing the earth in the future are energy, water, environment and food security, Green IT contributes in significant role in finding solutions because it consume energy more efficient and reduce pollution in water, air and soil in addition to improving economy because Green IT is manage energy sources by reducing energy consumption with good performance. Most of energy consumed around the world depends on non-renewable energy and part of this energy consumed to update technologies In this paper ,we will study one of the most important tools in Microsoft, which is used in order to help users to get updates of Microsoft's products, which is called windows server update services (WSUS, which is helping to reduce energy consumption, we will study this tool and then try to make it more green by reducing the send / receive between Microsoft Update (MU and WSUS, which will reduce energy consumption, and we will propose algorithm and compared the energy consumption in the current design with energy consumption in the proposed design. This design will open the way for future work in order to make sending updates in MU less energy consumption by apply conditional sending and that will help to improve the performance of MU added to improve the network performance with more efficient consumption of energy.

  15. Regular database update logics

    NARCIS (Netherlands)

    Spruit, Paul; Wieringa, Roel; Meyer, John-Jules

    2001-01-01

    We study regular first-order update logic (FUL), which is a variant of regular dynamic logic in which updates to function symbols as well as to predicate symbols are possible. We fi1rst study FUL without making assumptions about atomic updates. Second, we look at relational algebra update logic (RAU

  16. Varieties of update

    Directory of Open Access Journals (Sweden)

    Sarah E Murray

    2014-03-01

    Full Text Available This paper discusses three potential varieties of update: updates to the common ground, structuring updates, and updates that introduce discourse referents. These different types of update are used to model different aspects of natural language phenomena. Not-at-issue information directly updates the common ground. The illocutionary mood of a sentence structures the context. Other updates introduce discourse referents of various types, including propositional discourse referents for at-issue information. Distinguishing these types of update allows a unified treatment of a broad range of phenomena, including the grammatical evidentials found in Cheyenne (Algonquian as well as English evidential parentheticals, appositives, and mood marking. An update semantics that can formalize all of these varieties of update is given, integrating the different kinds of semantic contributions into a single representation of meaning. http://dx.doi.org/10.3765/sp.7.2 BibTeX info

  17. Updated safety analysis of ITER

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, Neill, E-mail: neill.taylor@iter.org [ITER Organization, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Baker, Dennis; Ciattaglia, Sergio; Cortes, Pierre; Elbez-Uzan, Joelle; Iseli, Markus; Reyes, Susana; Rodriguez-Rodrigo, Lina; Rosanvallon, Sandrine; Topilski, Leonid [ITER Organization, CS 90 046, 13067 St Paul Lez Durance Cedex (France)

    2011-10-15

    An updated version of the ITER Preliminary Safety Report has been produced and submitted to the licensing authorities. It is revised and expanded in response to requests from the authorities after their review of an earlier version in 2008, to reflect enhancements in ITER safety provisions through design changes, to incorporate new and improved safety analyses and to take into account other ITER design evolution. The updated analyses show that changes to the Tokamak cooling water system design have enhanced confinement and reduced potential radiological releases as well as removing decay heat with very high reliability. New and updated accident scenario analyses, together with fire and explosion risk analyses, have shown that design provisions are sufficient to minimize the likelihood of accidents and reduce potential consequences to a very low level. Taken together, the improvements provided a stronger demonstration of the very good safety performance of the ITER design.

  18. Titan's gravity: An update

    Science.gov (United States)

    Durante, D.; Iess, L.; Racioppa, P.; Armstrong, J. W.; Lunine, J. I.; Stevenson, D. J.; Tortora, P.

    2016-12-01

    Since its arrival at Saturn in 2004, Cassini performed nine flybys devoted to the determination of Titan's gravity field and its tidal variations. The last gravity flyby of the mission (T122) took place on Aug. 10, 2016. We will present an updated gravity solution, based on all available data. These include also an additional flyby (T110, March 2015, primarily devoted to the imaging Titan's north polar lakes) carried out with the low gain antenna. This flyby was particularly valuable because closest approach occurred at high latitude (75°N), over an area not previously sampled. Published gravity results (Iess et al., 2012) indicated that Titan is subject to large eccentricity tides in response to Saturn's time varying forcing field. The magnitude of the response quadrupole field, controlled by the Love number k2, was used to infer the existence of an internal ocean. The new gravity field determination provides a better estimate of k2, to a level of a few percent. In addition to a full 3x3 field, the new solution includes also higher degree and order harmonic coefficients (such as J4) and offers an improved map of gravity anomalies. The updated geoid and its associated uncertainty could be used to refine the gravity-altimetry correlative analysis and for improved interpretation of radar altimetric data.

  19. Breast Cancer Research Update

    Science.gov (United States)

    ... JavaScript on. Feature: Breast Cancer Breast Cancer Research Update Winter 2017 Table of Contents National Cancer Institute ... Addressing Breast Cancer's Unequal Burden / Breast Cancer Research Update Winter 2017 Issue: Volume 11 Number 4 Page ...

  20. Cardiology update

    Directory of Open Access Journals (Sweden)

    Sunil K Verma

    2015-01-01

    Full Text Available In the year 2014, there were certain remarkable trials that have changed the practice of cardiology and beyond that these tried to explained some long awaited unanswered questions. Like SIMPLICITY HTN-3 trial clearly explained the uselessness of renal denervation therapy in systemic hypertension. PARADIGM-HF trial provided positive data that may be useful to enrich the basket of medical treatment with a new drug LCZ 696 after a long time. Another important meta-analysis in heart failure questioned the status of beta blockers as standard therapy to improve prognosis in patients with concomitant heart failure and atrial fibrillation . In myocardial infraction , CvLPRIT trial supported the concept of complete revascularization at the time of primary PCI and TASTE trials failed to show expected benefit of thrombus aspiration in acute MI. FFR got more strength from FAME 2 trial. Another important question that was addressed in SECURITY trial was optimal duration of DAPT after second generation DES implantation. One year follow-up results of ABSORB II suggested that bioresorbable scaffolds are currently facing problem of stent thrombosis that might be taken care in near future with improvement in strut technology. Successful use of "Heart in a box" machine provided a major thrust for cardiac transplantation. SEARCH-AF evaluated the efficacy of a novel mobile health technology in the real world to screen for atrial fibrillation (now called as life style disease. A Meta-analysis provided a more comprehensive picture of the new oral anticoagulants as a therapeutic option in atrial fibrillation. Positive results for trans catheter pm-VSD closure in paediatric population were also demonstrated by a randomized controlled trial. Role of corticosteroids in tubercular pericarditis also got the answer in a trial published in 2014.

  1. Updates in ophthalmic pathology.

    Science.gov (United States)

    Mendoza, Pia R; Grossniklaus, Hans E

    2017-05-01

    Ophthalmic pathology has a long history and rich heritage in the field of ophthalmology. This review article highlights updates in ophthalmic pathology that have developed significantly through the years because of the efforts of committed individuals and the confluence of technology such as molecular biology and digital pathology. This is an exciting period in the history of ocular pathology, with cutting-edge techniques paving the way for new developments in diagnostics, therapeutics, and research. Collaborations between ocular oncologists and pathologists allow for improved and comprehensive patient care. Ophthalmic pathology continues to be a relevant specialty that is important in the understanding and clinical management of ocular disease, education of eye care providers, and overall advancement of the field.

  2. Marktontwikkeling biologische (vers)producten in de bedrijfscateringketen : eindrapport AKK

    NARCIS (Netherlands)

    Jong, de P.W.G.A.

    2004-01-01

    Binnen de doelstelling om in 2004 5% van de consumentenbestedingen aan biologische producten te laten uitgeven dient de bedrijfscatering een belangrijke rol te spelen. Gedurende de werkweek gebruiken miljoenen werknemers hun lunchmaaltijden in het bedrijfsrestaurant. Het introduceren van biologische

  3. Marketingconcepten voor huisverkoop van biologisch vlees : eindrapport AKK

    NARCIS (Netherlands)

    Heijden, van der C.H.T.M.; Puister-Jansen, L.F.; Hoste, R.; Meeusen-van Onna, M.J.G.; Wolf, C.W.G.

    2005-01-01

    Het project "Marketingconcepten voor de huisverkoop van biologisch vlees" is opgestart om huisverkoop van biologisch varkens- en rundvlees toegankelijker te maken. In de praktijk wordt nauwelijks nog samengewerkt en is de uitvoering erg verschillend. In het algemeen kan gezegd worden dat huisverkoop

  4. Colombia Mi Pronostico Flood Application: Updating and Improving the Mi Pronostico Flood Web Application to Include an Assessment of Flood Risk

    Science.gov (United States)

    Rushley, Stephanie; Carter, Matthew; Chiou, Charles; Farmer, Richard; Haywood, Kevin; Pototzky, Anthony, Jr.; White, Adam; Winker, Daniel

    2014-01-01

    Colombia is a country with highly variable terrain, from the Andes Mountains to plains and coastal areas, many of these areas are prone to flooding disasters. To identify these risk areas NASA's Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) was used to construct a digital elevation model (DEM) for the study region. The preliminary risk assessment was applied to a pilot study area, the La Mosca River basin. Precipitation data from the National Aeronautics and Space Administration (NASA) Tropical Rainfall Measuring Mission (TRMM)'s near-real-time rainfall products as well as precipitation data from the Instituto de Hidrologia, Meteorologia y Estudios Ambientales (the Institute of Hydrology, Meteorology and Environmental Studies, IDEAM) and stations in the La Mosca River Basin were used to create rainfall distribution maps for the region. Using the precipitation data and the ASTER DEM, the web application, Mi Pronóstico, run by IDEAM, was updated to include an interactive map which currently allows users to search for a location and view the vulnerability and current weather and flooding conditions. The geospatial information was linked to an early warning system in Mi Pronóstico that can alert the public of flood warnings and identify locations of nearby shelters.

  5. Country Update: Israel 2005

    Science.gov (United States)

    Marar, Marianne Maurice

    2005-01-01

    Country Updates is a new section of "Intercultural Education." Starting in "Intercultural Education," Volume 16 No. 5, this column will focus on recent developments during the last two to three years in the field of intercultural education in one particular country. These updates can include recent policy decisions, the main…

  6. Definition and kinematics of the northern of the Puerto Rico-Virgin Islands block and the Lesser Antilles forearc based on an updated and improved GPS velocity field and revised block models

    Science.gov (United States)

    Mattioli, G. S.; Jansma, P. E.; Stafford-Glenn, M.; Calais, E.

    2011-12-01

    The presence of small tectonic blocks the Greater Antilles, for example the Puerto Rico-Virgin Islands block (PRVI), which may be translating, rotating, and possibly internally deforming, has been proposed and some cases well-documented by several workers. In addition, the existence of a Lesser Antilles forearc has been proposed based on interplate earthquake slip vectors (Lopez et al. 2006). Manaker et al. (2008) used sparse GPS and earthquake slip data from the northeastern Caribbean to construct a DEFNODE block and fault model to constrain interseismic fault coupling among the microplates in the northeastern Caribbean. They concluded that the Enriquillo fault in Haiti could produce a Mw7.2, if the entire accumulated elastic strain was released in one event. On January 12, 2010, the strain was released in a Mw7.0 earthquake that left Port-au-Prince in rubble. The interseismic GPS velocity field has been updated for Hispanolia (Calais et al, 2010); in addition, new data have been collected in the northern Lesser Antilles (NLA) in 2009 as well as throughout the PRVI block in 2007 and 2011, and the existing GPS time series updated and transformed into ITRF05 (IGS05). GPS data from the NLA are consistent with a NLA forearc sliver that moves differently from the Caribbean and North American plates as originally proposed by Lopez et al. (2006). The forearc does not, however, continue as single tectonic entity across the Anegada Passage as previously suggested. Here we report revised DEFNODE models using both the original geometry and constraints of Manaker et al. (2008) with an updated GPS data set as well as new models that explicitly include a forearc block. The models may be used to explicitly define the rotation parameters of the block as well as the coupling along block bounding faults. The original model geometry (without a forearc sliver) yields a higher reduced chi-squared (2.57 vs. 2.01), when additional the GPS velocities from NLA are used to condition the

  7. USDA-ARS research update: Improved solid-liquid separation using polymers in flushing systems and new technology to recover the ammonia from covered lagoons

    Science.gov (United States)

    Part 1: Improved method for recovery of organic solids from diluted swine manure: Solid-liquid separation of the raw manure increases the capacity of decision making and opportunities for treatment. The high-rate separation up-front using flocculants allows recovery of most of the organic compounds,...

  8. Controlling acute pain to improve the quality of postoperative pain management: an update from the European Society of Regional Anesthesia meeting held in Maastricht (September 2016).

    Science.gov (United States)

    Andrés, Jose De; Pogatzki-Zahn, Esther; Huygen, Frank; Neugebauer, Edmund; Fawcett, William

    2017-08-10

    Improvement in postoperative pain management remains a global concern with a significant unmet need for patients. This was the focus of a 'Change Pain' session at the 35th European Society of Regional Anesthesia meeting (Maastricht, September 2016). Awareness of the size and nature of the problem is important to improve postoperative pain management strategies. Optimal treatment of acute pain should aim to avoid long-term sequelae such as the development of chronic pain disorders (e.g., phantom limb pain). Cases highlighting unsuccessful and successful strategies to manage individuals undergoing surgery were presented. The benefits of personalized care, encouraging patients to be more involved in decisions regarding their treatment and their preferred clinical outcomes were discussed and considered to be a step forward in acute pain management.

  9. Improving the Lives of the Poor Through Investment in Cities : An Update on the Performance of the World Bank's Urban Portfolio

    OpenAIRE

    Roy Gilbert

    2003-01-01

    The central theme addressed by this evaluation, is whether the Bank ' s investment in cities, improved the lives of the poor. This report is based on a desk review of the Bank's urban portfolio. It focuses on the results of the 99 operations completed in the past 10 years. It uses the four pillars of livability, good governance, bankability, and competitiveness of the Urban Strategy Paper ...

  10. Research on Topographic Map Updating

    Directory of Open Access Journals (Sweden)

    Ivana Javorović

    2013-04-01

    Full Text Available The investigation of interpretability of panchromatic satellite image IRS-1C integrated with multispectral Landsat TM image with the purpose of updating the topographic map sheet at the scale of 1:25 000 has been described. The geocoding of source map was based on trigonometric points of the map sheet. Satellite images were geocoded using control points selected from the map. The contents of map have been vectorized and topographic database designed. The digital image processing improved the interpretability of images. Then, the vectorization of new contents was made. The change detection of the forest and water area was defined by using unsupervised classification of spatial and spectral merged images. Verification of the results was made using corresponding aerial photographs. Although this methodology could not insure the complete updating of topographic map at the scale of 1:25 000, the database has been updated with huge amount of data. Erdas Imagine 8.3. software was used. 

  11. Stochastic model updating using distance discrimination analysis

    Institute of Scientific and Technical Information of China (English)

    Deng Zhongmin; Bi Sifeng; Sez Atamturktur

    2014-01-01

    This manuscript presents a stochastic model updating method, taking both uncertainties in models and variability in testing into account. The updated finite element (FE) models obtained through the proposed technique can aid in the analysis and design of structural systems. The authors developed a stochastic model updating method integrating distance discrimination analysis (DDA) and advanced Monte Carlo (MC) technique to (1) enable more efficient MC by using a response surface model, (2) calibrate parameters with an iterative test-analysis correlation based upon DDA, and (3) utilize and compare different distance functions as correlation metrics. Using DDA, the influence of distance functions on model updating results is analyzed. The proposed sto-chastic method makes it possible to obtain a precise model updating outcome with acceptable cal-culation cost. The stochastic method is demonstrated on a helicopter case study updated using both Euclidian and Mahalanobis distance metrics. It is observed that the selected distance function influ-ences the iterative calibration process and thus, the calibration outcome, indicating that an integra-tion of different metrics might yield improved results.

  12. Veterinary medicines update.

    Science.gov (United States)

    2017-03-11

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues.

  13. 提高安全培训质量重在教材更新%Improving the Quality of Safety Training Should Focus on Updating the Materials

    Institute of Scientific and Technical Information of China (English)

    郭健

    2011-01-01

    安全生产是企业生存和发展的重要条件,安全培训则是安全生产的基础。要提高安全培训的针对性、实效性,确保安全培训的质量和效果。除了要引用现代培训新理念,创新安全培训模式,创新安全培训内容,方式、方法外,如何提高安全培训教材质量,使之适应不断发展变化的生产技术、生产人员的需要,显得尤为重要。%Work safety is important for the enterprises'survival and development. Work safety is the foundation for safety training. In order to improve the effectiveness of safety training and ensure the quality and the effect of safety training, we need to in: troduce new concept of modem training, create new safety training mode, and innovate the contents, methods of safety training. In addition, it is particularly important to improve the quality of safety training materials in order to meet the needs of the changing production technology, production personnel.

  14. An Update on Maternal Hydration Strategies for Amniotic Fluid Improvement in Isolated Oligohydramnios and Normohydramnios: Evidence from a Systematic Review of Literature and Meta-Analysis.

    Directory of Open Access Journals (Sweden)

    Salvatore Gizzo

    Full Text Available Several trials aimed at evaluating the efficacy of maternal hydration (MH in increasing amniotic-fluid-volume (AFV in pregnancies with isolated oligohydramnios or normohydramnos have been conducted. Unfortunately, no evidences support this intervention in routine-clinical-practice. The aim of this systematic-literature-review and meta-analysis was to collect all data regarding proposed strategies and their efficacy in relation to each clinical condition for which MH-therapy was performed with the aim of increasing amniotic-fluid (AF and improving perinatal outcomes.A systematic literature search was conducted in electronic-database MEDLINE, EMBASE, ScienceDirect and the Cochrane-Library in the time interval between 1991 and 2014. Following the identification of eligible trials, we estimated the methodological quality of each study (using QADAS-2 and clustered patients according to the following outcome measures: route of administration (oral versus intravenous versus combined, total daily dose of fluids administered (2000, duration of hydration therapy: (1 day, >1 day but 1 week, type of fluid administered (isotonic versus hypotonic versus combination.In isolated-oligohydramnios (IO, maternal oral hydration is more effective than intravenous hydration and hypotonic solutions superior to isotonic solutions. The improvement in AFV appears to be time-dependent rather than daily-dose dependent. Regarding normohydramnios pregnancies, all strategies seem equivalent though the administration of hypotonic-fluid appears to have a slightly greater effect than isotonic-fluid. Regarding perinatal outcomes, data is fragmentary and heterogeneous and does not allow us to define the real clinical utility of MH.Available data suggests that MH may be a safe, well-tolerated and useful strategy to improve AFV especially in cases of IO. In view of the numerous obstetric situations in which a reduced AFV may pose a threat, particularly to the fetus, the possibility

  15. Update on biosimilars in rheumatology.

    Science.gov (United States)

    Rischin, Adam; Östör, Andrew J K

    2017-04-01

    Biologic agents have become indispensable in the management of autoimmune disease particularly rheumatological conditions. The lives of countless individuals have been improved following treatment with these drugs. Unfortunately, their cost prohibits more widespread use around the globe. This critical issue has been addressed by the introduction of biosimilars into the market. These therapies have been developed to resemble the originator molecule as closely as possible and to increase competition in the therapy area thus allowing costs to be reduced. Our review is intended to offer an update on biosimilars including logistic considerations on their introduction into routine practice.

  16. Cushing syndrome: update on testing.

    Science.gov (United States)

    Raff, Hershel

    2015-03-01

    Endogenous hypercortisolism (Cushing syndrome) is one of the most enigmatic diseases in clinical medicine. The diagnosis and differential diagnosis of Cushing syndrome depend on proper laboratory evaluation. In this review, an update is provided on selected critical issues in the diagnosis and differential diagnosis of Cushing syndrome: the use of late-night salivary cortisol in initial diagnosis and for postoperative surveillance, and the use of prolactin measurement to improve the performance of inferior petrosal sinus sampling to distinguish Cushing disease from ectopic adrenocorticotropic hormone (ACTH) syndrome during differential diagnosis of ACTH-dependent Cushing syndrome. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. Clean Coal Technology Programs: Program Update 2009

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-10-01

    The purpose of the Clean Coal Technology Programs: Program Update 2009 is to provide an updated status of the U.S. Department of Energy (DOE) commercial-scale demonstrations of clean coal technologies (CCT). These demonstrations have been performed under the Clean Coal Technology Demonstration Program (CCTDP), the Power Plant Improvement Initiative (PPII), and the Clean Coal Power Initiative (CCPI). Program Update 2009 provides: (1) a discussion of the role of clean coal technology demonstrations in improving the nation’s energy security and reliability, while protecting the environment using the nation’s most abundant energy resource—coal; (2) a summary of the funding and costs of the demonstrations; and (3) an overview of the technologies being demonstrated, along with fact sheets for projects that are active, recently completed, or recently discontinued.

  18. Important update of CERN Mail Services

    CERN Multimedia

    IT Department

    2009-01-01

    The CERN Mail Services are evolving. In the course of June and July 2009, all CERN mailboxes will be updated with a new infrastructure for hosting mailboxes, running Exchange 2007. This update is taking place in order to provide the capacity upgrade for the constantly growing volume of CERN mailboxes. It is also the opportunity to provide a number of improvements to CERN mailboxes: new and improved Outlook Web Access (the web interface used to access your mailbox from a web browser, also known as "webmail"), new features in the Out-of-Office auto-reply assistant, easier spam management... The update will preserve the mailbox configuration and no specific action is required by users. During the next weeks, each mailbox will be individually notified of the upcoming update the day before it takes place. We invite all users to carefully read this notification as it will contain the latest information for this update. The mailbox will be unavailable for a short time during the ni...

  19. Effectiveness of an educational intervention to improve child feeding practices and growth in rural China: updated results at 18 months of age.

    Science.gov (United States)

    Zhang, Jingxu; Shi, Ling; Chen, Da-Fang; Wang, Jing; Wang, Yan

    2013-01-01

    Inappropriate complementary feeding practices have led to, in part, significant disparities in growth and nutritional status between rural and urban children in China. A cluster-randomised, controlled trial was implemented in Laishui, China to assess the effectiveness of an educational intervention on caregivers' feeding practices and children's growth. Eight townships were randomly assigned to the intervention or control. Five hundred ninety-nine healthy infants were enrolled at 2-4 months old, and were followed up at ages 6, 9, 12, 15 and 18 months. The intervention group received information on enhanced home-prepared recipes and food preparation and hygiene through group training, counselling and home visit. Key outcomes were children's physical growth, caregivers' knowledge and behaviours on complementary feeding, and the infant and child feeding index (ICFI). Analysis was by intention to treat. The intervention group achieved better knowledge and practices related to complementary feeding, and significantly higher ICFI scores at each follow-up point. Children in the intervention group achieved higher z-scores for weight-for-age (WAZ) and weight-for-height (WHZ) than the control (0.18 vs. 0.01 and 0.49 vs. 0.19, respectively) at 18 months old, and were less likely to have stunted growth (odds ratio = 0.71, 95% confidence interval: 0.53-0.94). Mixed model showed that the intervention group achieved significantly better linear growth over time, including WAZ (P = 0.016), WHZ (P = 0.030) and HAZ (P = 0.078). These results indicated that an educational intervention delivered through local health services can enhance caregivers' knowledge and practices of complementary feeding and ultimately improve children's growth.

  20. An update: improvements in imaging perfluorocarbon-mounted plant leaves with implications for studies of plant pathology, physiology, development and cell biology.

    Directory of Open Access Journals (Sweden)

    George R Littlejohn

    2014-04-01

    Full Text Available Plant leaves are optically complex, which makes them difficult to image by light microscopy. Careful sample preparation is therefore required to enable researchers to maximise the information gained from advances in fluorescent protein labelling, cell dyes and innovations in microscope technologies and techniques. We have previously shown that mounting leaves in the non-toxic, non-fluorescent perfluorocarbon (PFC, perfluorodecalin (PFD enhances the optical properties of the leaf with minimal impact on physiology. Here, we assess the use of the perfluorocarbons PFD, and perfluoroperhydrophenanthrene (PP11 for in vivo plant leaf imaging using 4 advanced modes of microscopy: laser scanning confocal microscopy (LSCM, Two-photon fluorescence (TPF microscopy, second harmonic generation (SHG microscopy and stimulated Raman scattering (SRS microscopy. For every mode of imaging tested, we observed an improved signal when leaves were mounted in PFD or in PP11, compared to mounting the samples in water. Using an image analysis technique based on autocorrelation to quantitatively assess LSCM image deterioration with depth, we show that PP11 outperformed PFD as a mounting medium by enabling the acquisition of clearer images deeper into the tissue. In addition, we show that SRS microscopy can be used to image perfluorocarbons directly in the mesophyll and thereby easily delimit the negative space within a leaf, which may have important implications for studies of leaf development. Direct comparison of on and off resonance SRS micrographs show that PFCs do not to form intracellular aggregates in live plants. We conclude that the application of PFCs as mounting media substantially increases advanced microscopy image quality of living mesophyll and leaf vascular bundle cells.

  1. Update of the CERN exchange switches

    CERN Multimedia

    2005-01-01

    In the context of the telephony services improvements, an update of the CERN exchange switches will be performed on Thursday 28 April from 7.00 p.m. until midnight. Disturbances or even disruptions of telephony services may occur during this intervention

  2. Update of European bioethics

    DEFF Research Database (Denmark)

    Rendtorff, Jacob Dahl

    2015-01-01

    This paper presents an update of the research on European bioethics undertaken by the author together with Professor Peter Kemp since the 1990s, on Basic ethical principles in European bioethics and biolaw. In this European approach to basic ethical principles in bioethics and biolaw, the princip......This paper presents an update of the research on European bioethics undertaken by the author together with Professor Peter Kemp since the 1990s, on Basic ethical principles in European bioethics and biolaw. In this European approach to basic ethical principles in bioethics and biolaw......, the principles of autonomy, dignity, integrity and vulnerability are proposed as the most important ethical principles for respect for the human person in biomedical and biotechnological development. This approach to bioethics and biolaw is presented here in a short updated version that integrates the earlier...

  3. Multiple Sclerosis: An Update.

    Science.gov (United States)

    Faguy, Kathryn

    2016-05-01

    Multiple sclerosis (MS) is the most common disabling neurologic condition in young adults and imposes high financial and quality of life costs on patients, their families, and society. Yet, developments in the battle against MS include new treatments to slow its progression and updated diagnostic criteria that can accelerate diagnosis and effective treatment. This article offers a review and update on the disease, focusing on risk factors and possible causes, symptoms, forms of MS, diagnostic criteria and tools, and the expanding array of approved treatments. It also reports on the skyrocketing cost of MS drugs, misdiagnosis, and special patient populations with MS.

  4. PUMA: The Positional Update and Matching Algorithm

    Science.gov (United States)

    Line, J. L. B.; Webster, R. L.; Pindor, B.; Mitchell, D. A.; Trott, C. M.

    2017-01-01

    We present new software to cross-match low-frequency radio catalogues: the Positional Update and Matching Algorithm. The Positional Update and Matching Algorithm combines a positional Bayesian probabilistic approach with spectral matching criteria, allowing for confusing sources in the matching process. We go on to create a radio sky model using Positional Update and Matching Algorithm based on the Murchison Widefield Array Commissioning Survey, and are able to automatically cross-match 98.5% of sources. Using the characteristics of this sky model, we create simple simulated mock catalogues on which to test the Positional Update and Matching Algorithm, and find that Positional Update and Matching Algorithm can reliably find the correct spectral indices of sources, along with being able to recover ionospheric offsets. Finally, we use this sky model to calibrate and remove foreground sources from simulated interferometric data, generated using OSKAR (the Oxford University visibility generator). We demonstrate that there is a substantial improvement in foreground source removal when using higher frequency and higher resolution source positions, even when correcting positions by an average of 0.3 arcmin given a synthesised beam-width of 2.3 arcmin.

  5. Model updating of a full-scale FE model with nonlinear constraint equations and sensitivity-based cluster analysis for updating parameters

    Science.gov (United States)

    Jang, Jinwoo; Smyth, Andrew W.

    2017-01-01

    The objective of structural model updating is to reduce inherent modeling errors in Finite Element (FE) models due to simplifications, idealized connections, and uncertainties of material properties. Updated FE models, which have less discrepancies with real structures, give more precise predictions of dynamic behaviors for future analyses. However, model updating becomes more difficult when applied to civil structures with a large number of structural components and complicated connections. In this paper, a full-scale FE model of a major long-span bridge has been updated for improved consistency with real measured data. Two methods are applied to improve the model updating process. The first method focuses on improving the agreement of the updated mode shapes with the measured data. A nonlinear inequality constraint equation is used to an optimization procedure, providing the capability to regulate updated mode shapes to remain within reasonable agreements with those observed. An interior point algorithm deals with nonlinearity in the objective function and constraints. The second method finds very efficient updating parameters in a more systematic way. The selection of updating parameters in FE models is essential to have a successful updating result because the parameters are directly related to the modal properties of dynamic systems. An in-depth sensitivity analysis is carried out in an effort to precisely understand the effects of physical parameters in the FE model on natural frequencies. Based on the sensitivity analysis, cluster analysis is conducted to find a very efficient set of updating parameters.

  6. An Updated AP2 Beamline TURTLE Model

    Energy Technology Data Exchange (ETDEWEB)

    Gormley, M.; O' Day, S.

    1991-08-23

    This note describes a TURTLE model of the AP2 beamline. This model was created by D. Johnson and improved by J. Hangst. The authors of this note have made additional improvements which reflect recent element and magnet setting changes. The magnet characteristics measurements and survey data compiled to update the model will be presented. A printout of the actual TURTLE deck may be found in appendix A.

  7. XLMR genes: update 2000.

    NARCIS (Netherlands)

    Chiurazzi, P.; Hamel, B.C.J.; Neri, G.

    2001-01-01

    This is the sixth edition of the catalogue of XLMR genes, ie X-linked genes whose malfunctioning causes mental retardation. The cloning era is not yet concluded, actually much remains to be done to account for the 202 XLMR conditions listed in this update. Many of these may eventually prove to be du

  8. Updating Older Fume Hoods.

    Science.gov (United States)

    Saunders, G. Thomas

    1985-01-01

    Provides information on updating older fume hoods. Areas addressed include: (1) adjustment of the hood's back baffle; (2) hood air leakage; (3) light level; (4) hood location in relation to room traffic and room air; and (5) establishing and maintaining hood performance. (JN)

  9. Update of telephone exchange

    CERN Multimedia

    2006-01-01

    As part of the upgrade of telephone services, the CERN switching centre will be updated on between Monday 23 October 8.00 p.m. and Tuesday 24 October 2.00 a.m. Telephone services may be disrupted and possibly even interrupted during this operation. We apologise in advance for any inconvenience this may cause. CERN TELECOM Service

  10. Update of telephone exchange

    CERN Multimedia

    2006-01-01

    As part of the upgrade of telephone services, the CERN switching centre will be updated on Monday 3 July between 8.00 p.m. and 3.00 a.m. Telephone services may be disrupted and possibly even interrupted during this operation. We apologise in advance for any inconvenience this may cause. CERN TELECOM Service

  11. Update of telephone exchange

    CERN Multimedia

    2006-01-01

    As part of the upgrade of telephone services, the CERN switching centre will be updated on Wednesday 14 June between 8.00 p.m. and midnight. Telephone services may be disrupted and possibly even interrupted during this operation. We apologise in advance for any inconvenience this may cause. CERN TELECOM Service

  12. Update of telephone exchange

    CERN Multimedia

    2006-01-01

    As part of the upgrade of telephone services, the CERN switching centre will be updated on Monday 3 July between 8.00 p.m. and 3.00 a.m. Telephone services may be disrupted and possibly even interrupted during this operation.We apologise in advance for any inconvenience this may cause. CERN TELECOM Service

  13. Sugammadex: An Update

    Directory of Open Access Journals (Sweden)

    Ezri Tiberiu

    2016-01-01

    Full Text Available The purpose of this update is to provide recent knowledge and debates regarding the use of sugammadex in the fields of anesthesia and critical care. The review is not intended to provide a comprehensive description of sugammadex and its clinical use.

  14. AN OPTIMAL SELF-SCALING STRATEGY TO THE MODIFIED SYMMETRIC RANK ONE UPDATING

    Institute of Scientific and Technical Information of China (English)

    Yang Yueting; Xu Chengxian; Gao Yuelin

    2005-01-01

    In the paper, the optimal self-scaling strategy to the modified symmetric rank one (HSR1) update, which satisfies the modified quasi-Newton equation, is derived to improve the condition number of the updates. The scaling factors are derived from minimizing the estimate of upper bounds on the condition number of the updating matrix. Theoretical analysis, and numerical experiments and comparisons show that introducing the optimal scaling factor into the modified symmetric rank one update preserves the positive definiteness of updates, and greatly improves the stability and numerical performance of the modified symmetric rank one algorithm.

  15. GPGPU for orbital function evaluation with a new updating scheme.

    Science.gov (United States)

    Uejima, Yutaka; Maezono, Ryo

    2013-01-15

    We have accelerated an ab initio quantum Monte Carlo electronic structure calculation using general purpose computing on graphical processing units (GPGPU). The part of the code causing the bottleneck for extended systems is replaced by Compute Unified Device Architecture-GPGPU subroutine kernels which build up spline basis set expansions of electronic orbital functions at each Monte Carlo step. We have achieved a speedup of a factor of 30 for the bottleneck for a simulation of solid TiO(2) with 1536 electrons. To improve the performance with GPGPU we propose a new updating scheme for Monte Carlo sampling, quasi-simultaneous updating, which is intermediate between configuration-by-configuration updating and the widely used particle-by-particle updating. The error in the energy due to by the single precision treatment and the new updating scheme is found to be within the required accuracy of ~10(-3) hartree per primitive cell.

  16. Recycling, Canadian update

    Energy Technology Data Exchange (ETDEWEB)

    Lakshmanan, V. I. [Process Research ORTECH Inc., Mississauga, ON (Canada); Shaw, L. [Canadian Association of Recycling Industries, Almonte, ON (Canada)

    2001-07-01

    An update on the recycling industry in Canada is provided by way of selected examples involving the recovery of gallium from electronic scrap, magnesium recovery from mine tailings and energy recovery from metal industry processes. These examples have been selected to illustrate the synergy between major mining, metallurgical and utility industries with end users in the building materials, automotive and electronic industries. 1 tab., 1 fig.

  17. Annual Pension Fund Update

    CERN Multimedia

    Pension Fund

    2011-01-01

    All members and beneficiaries of the Pension Fund are invited to attend the Annual Pension Fund Update to be held in the CERN Council Chamber on Tuesday 20 September 2011 from 10-00 to 12-00 a.m. Copies of the 2010 Financial Statements are available from departmental secretariats. Coffee and croissants will be served prior to the meeting as of 9-30 a.m.

  18. Ukraine Poverty Update

    OpenAIRE

    2007-01-01

    Ukraine recorded one of the sharpest declines in poverty of any transition economy in recent years. The poverty rate, measured against an absolute poverty line, fell from a high of 32 percent in 2001 to 14 percent in 2004, and then again to 8 percent in 2005. This Update presents simulations of the direct influence of an increase in energy prices on the poverty rate. Using 2005 as a base p...

  19. How Documentalists Update SIMBAD

    Science.gov (United States)

    Buga, M.; Bot, C.; Brouty, M.; Bruneau, C.; Brunet, C.; Cambresy, L.; Eisele, A.; Genova, F.; Lesteven, S.; Loup, C.; Neuville, M.; Oberto, A.; Ochsenbein, F.; Perret, E.; Siebert, A.; Son, E.; Vannier, P.; Vollmer, B.; Vonflie, P.; Wenger, M.; Woelfel, F.

    2015-04-01

    The Strasbourg astronomical Data Center (CDS) was created in 1972 and has had a major role in astronomy for more than forty years. CDS develops a service called SIMBAD that provides basic data, cross-identifications, bibliography, and measurements for astronomical objects outside the solar system. It brings to the scientific community an added value to content which is updated daily by a team of documentalists working together in close collaboration with astronomers and IT specialists. We explain how the CDS staff updates SIMBAD with object citations in the main astronomical journals, as well as with astronomical data and measurements. We also explain how the identification is made between the objects found in the literature and those already existing in SIMBAD. We show the steps followed by the documentalist team to update the database using different tools developed at CDS, like the sky visualizer Aladin, and the large catalogues and survey database VizieR. As a direct result of this teamwork, SIMBAD integrates almost 10.000 bibliographic references per year. The service receives more than 400.000 queries per day.

  20. GMRT-EoR Project Update

    Science.gov (United States)

    Chang, Tzu-Ching; GMRT-EoR Team

    2013-01-01

    The GMRT-EoR project has continued the multi-year campaign to measure the neutral hydrogen 21cm fluctuations at z=8.5, probing the reionization epoch using the Giant Metrewave Radio Telescope (GMRT) in India. We have acquired new data and continued to improve our analysis strategy and process. To cope with the stringent foreground subtraction requirement, our team has developed a new method for component separation; I will present updates on the latest analysis and future prospects.

  1. Neuman systems model in holland: an update.

    Science.gov (United States)

    Merks, André; Verberk, Frans; de Kuiper, Marlou; Lowry, Lois W

    2012-10-01

    The authors of this column, leading members of the International Neuman Systems Model Association, provide an update on the use of Neuman systems model in Holland and document the various changes in The Netherlands that have influenced the use of the model in that country. The model's link to systems theory and stress theory are discussed, as well as a shift to greater emphasis on patient self-management. The model is also linked to healthcare quality improvement and interprofessional collaboration in Holland.

  2. An updated equation for the refractive index of air

    Science.gov (United States)

    Li, Wenchen; Dai, Zuoxiao; Dai, Ning; Chen, Ren; Sun, Xiaojie; Xia, Xiang; Li, Tao; Ma, Bei; Sheng, Hao

    2014-12-01

    Laser has been widely used in spectroscopic and metrological measurement. High-precision laser metrology is affected by the refractive index of air. In order to apply the algorithm for the refractive index of air in some situation where low calculation complexity and high-precision are needed, the algorithm of the refractive index of Rueger is updated. As the errors of Rueger's algorithm are mainly affected by temperature, humidity, and the concentration of carbon dioxide in the atmosphere as well as laser wavelength, we do some revisions about these effects of the factors of atmosphere in Rueger's algorithm. The conditions of standard air is redefined in this paper because of the average concentration of carbon dioxide in the atmosphere has been changed in the past few decades. As the concentration of carbon dioxide in the air is not constant, the effect of carbon dioxide on the refractive index of air is taken into consideration in the updated algorithm. The updated algorithm adapts to the real atmosphere well. The effects of dry air and humid air on the algorithm are also corrected, and the refractive index of air calculated by the updated algorithm is much closer to that of Philip E.Ciddor's algorithm defined as reference algorithm in the paper because of its high-precision. The performance of the updated algorithm is also analyzed in this paper. It is compared to that of the reference algorithm and the real measured data. Comparing results show that the performance of the algorithm has been improved after the correction. Comparing to the reference algorithm, the performance of the updated algorithm is a little bit lower, but the updated algorithm is much simpler and easier to be applied. Comparing to Rueger's algorithm, the performance of the updated algorithm is much higher and the complexity of the updated algorithm increases very small. The updated algorithm meets low calculation complexity and high-precision requirements.

  3. Cohort Profile Update

    DEFF Research Database (Denmark)

    Omland, Lars Haukali; Ahlström, Magnus Glindvad; Obel, Niels

    2014-01-01

    The DHCS is a cohort of all HIV-infected individuals seen in one of the eight Danish HIV centres after 31 December 1994. Here we update the 2009 cohort profile emphasizing the development of the cohort. Every 12-24 months, DHCS is linked with the Danish Civil Registration System (CRS) in order...... of Causes of Death, the Danish National Prescription Registry, the Attainment Register and the Integrated Database for Labour Market Research to get information on vital status, migration, cancer, hospital contacts, causes of death, dispensed prescriptions, education and employment. Using this design, rates...

  4. Context updates are hierarchical

    Directory of Open Access Journals (Sweden)

    Anton Karl Ingason

    2016-10-01

    Full Text Available This squib studies the order in which elements are added to the shared context of interlocutors in a conversation. It focuses on context updates within one hierarchical structure and argues that structurally higher elements are entered into the context before lower elements, even if the structurally higher elements are pronounced after the lower elements. The crucial data are drawn from a comparison of relative clauses in two head-initial languages, English and Icelandic, and two head-final languages, Korean and Japanese. The findings have consequences for any theory of a dynamic semantics.

  5. Updates in pediatric endocrinology.

    Science.gov (United States)

    Kamboj, Manmohan K

    2013-04-01

    There are rapid advances being made in the field of medicine! New research continues to investigate etiopathogenic mechanisms underlying many endocrine disorders, new tests to facilitate diagnosis, and newer treatment options. The discussion in this article focuses on a few of the important concerns in adolescent endocrinology and highlights some recent concepts that are important for the physicians taking care of these adolescents. This article also includes a brief update on diabetes mellitus types 1 and 2, obesity, and polycystic ovarian syndrome; new thoughts and controversies about vitamin D and current management of the common thyroid disorders; adrenal insufficiency; and concerns with disorders of puberty in adolescents.

  6. Lodging Update: Greater Boston

    Directory of Open Access Journals (Sweden)

    Rachel Roginsky

    2012-09-01

    Full Text Available Pinnacle Advisory Group provides an update of lodging industry performance in New England and Boston for the first half of 2012. While the New England region outpaced the nation, the specific story varies from state to state. Only Massachusetts and Vermont achieved REVPAR performance better than the national average. A review of the Greater Boston lodging market reveals that a healthy local economy and strong convention calendar, combined with a number of one-time events and limited new supply, boosted the local market in 2012. The outlook for 2013 in Greater Boston remains positive, with expectations of a 4.7% growth in REVPAR.

  7. Craniosynostosis update 1987.

    Science.gov (United States)

    Cohen, M M

    1988-01-01

    Information on craniosynostosis in this paper updates "Craniosynostosis: Diagnosis, Evaluation, and Management" (Cohen MM Jr: New York: Raven Press, 1986). It also discusses recent developments that were included in the book but need further explanation or emphasis. Subjects discussed are: epidemiology, etiology, sutural biology, growth and development, neurological and psychosocial aspects, surgery, cloverleaf skulls, craniosynostosis syndromes, and prenatal diagnosis. Under the subject of etiology, fetal head constraint, maternal thyroid disease, calcified cephalohematoma, teratogens, and delayed suture closure and Wormian bones are considered. An updating of 15 cloverleaf skull conditions includes four monogenic disorders, two chromosomal disorders, one disruption, one iatrogenic condition, and seven syndromes of unknown cause. Newly recognized disorders with cloverleaf skull include Beare-Stevenson cutis gyratum syndrome and Say-Poznanski syndrome. Craniosynostosis syndromes and associations discussed include acrocraniofacial dysostosis, Apert syndrome, Beare-Stevenson cutis gyratum syndrome, Calabro syndrome, calvarial hyperostosis, chromosomal craniostenosis, Cole-Carpenter type osteogenesis imperfecta, Crouzon syndrome, Curry-Jones syndrome, Curry variant of Carpenter syndrome, cutis aplasia and cranial stenosis, Fontaine-Farriaux syndrome, Gomex-López-Hernández syndrome, Hersh syndrome, hyper-IgE syndrome and craniostenosis, hypomandibular faciocranial dysostosis, Marfanoid features and craniostenosis, Pfeiffer-type cardiocranial syndrome, Pfeiffer-type dolichocephalosyndactyly, and Say-Barber syndrome.

  8. CONSULTATION ON UPDATED METHODOLOGY FOR ...

    Science.gov (United States)

    The National Academy of Sciences (NAS) expects to publish the Biological Effects of Ionizing Radiation (BEIR) committee's report (BEIR VII) on risks from ionizing radiation exposures in calendar year 2005. The committee is expected to have analyzed the most recent epidemiology from the important exposed cohorts and to have factored in any changes resulting from the updated analysis of dosimetry for the Japanese atomic bomb survivors. To the extent practical, the Committee will also consider any relevant radiobiological data, including those from the Department of Energy's low dose effects research program. Based on their evaluation of relevant information, the Committee is then expected to propose a set of models for estimating risks from low-dose ionizing radiation. ORIA will review the BEIR VII report and consider revisions to the Agency's methodology for estimating cancer risks from exposure to ionizing radiation in light of this report and other relevant information. This will be the subject of the Consultation. This project supports a major risk management initiative to improve the basis on which radiation risk decisions are made. This project, funded by several Federal Agencies, reflects an attempt to characterize risks where there are substantial uncertainties. The outcome will improve our ability to assess risks well into the future and will strengthen EPAs overall capability for assessing and managing radiation risks. the BEIR VII report is funde

  9. Working Memory Updating Latency Reflects the Cost of Switching between Maintenance and Updating Modes of Operation

    Science.gov (United States)

    Kessler, Yoav; Oberauer, Klaus

    2014-01-01

    Updating and maintenance of information are 2 conflicting demands on working memory (WM). We examined the time required to update WM (updating latency) as a function of the sequence of updated and not-updated items within a list. Participants held a list of items in WM and updated a variable subset of them in each trial. Four experiments that vary…

  10. CESM/CAM5 improvement and application: comparison and evaluation of updated CB05_GE and MOZART-4 gas-phase mechanisms and associated impacts on global air quality and climate

    Science.gov (United States)

    He, J.; Zhang, Y.; Tilmes, S.; Emmons, L.; Lamarque, J.-F.; Glotfelty, T.; Hodzic, A.; Vitt, F.

    2015-12-01

    Atmospheric chemistry plays a key role in determining the amounts and distributions of oxidants and gaseous precursors that control the formation of secondary gaseous and aerosol pollutants; all of those species can interact with the climate system. To understand the impacts of different gas-phase mechanisms on global air quality and climate predictions, in this work, a comprehensive comparative evaluation is performed using the Community Atmosphere Model (CAM) Version 5 with comprehensive tropospheric and stratospheric chemistry (CAM5-chem) within the Community Earth System Model (CESM) with the two most commonly used gas-phase chemical mechanisms: the 2005 Carbon Bond mechanism with Global Extension (CB05_GE) and the Model of OZone and Related chemical Tracers version 4 (MOZART-4) mechanism with additional updates (MOZART-4x). MOZART-4x and CB05_GE use different approaches to represent volatile organic compounds (VOCs) and different surrogates for secondary organic aerosol (SOA) precursors. MOZART-4x includes a more detailed representation of isoprene chemistry compared to CB05_GE. CB05_GE includes additional oxidation of SO2 by O3 over the surface of dust particles, which is not included in MOZART-4x. The results show that the two CAM5-chem simulations with CB05_GE and MOZART-4x predict similar chemical profiles for major gases (e.g., O3, CO, and NOx) compared to the aircraft measurements, with generally better agreement for NOy profiles by CB05_GE than MOZART-4x. The concentrations of SOA at four sites in the continental US (CONUS) and organic carbon (OC) over the IMPROVE sites are well predicted by MOZART-4x (with normalized mean biases (NMBs) of -1.9 and 2.1 %, respectively) but moderately underpredicted by CB05_GE (with NMBs of -23.1 and -20.7 %, respectively). This is mainly due to the higher biogenic emissions and OH levels simulated with MOZART-4x than with CB05_GE. The concentrations of OC over Europe are largely underpredicted by both MOZART-4x and CB05

  11. Memory updating and mental arithmetic

    Directory of Open Access Journals (Sweden)

    Cheng-Ching eHan

    2016-02-01

    Full Text Available Is domain-general memory updating ability predictive of calculation skills or are such skills better predicted by the capacity for updating specifically numerical information? Here, we used multidigit mental multiplication (MMM as a measure for calculating skill as this operation requires the accurate maintenance and updating of information in addition to skills needed for arithmetic more generally. In Experiment 1, we found that only individual differences with regard to a task updating numerical information following addition (MUcalc could predict the performance of MMM, perhaps owing to common elements between the task and MMM. In Experiment 2, new updating tasks were designed to clarify this: a spatial updating task with no numbers, a numerical task with no calculation, and a word task. The results showed that both MUcalc and the spatial task were able to predict the performance of MMM but only with the more difficult problems, while other updating tasks did not predict performance. It is concluded that relevant processes involved in updating the contents of working memory support mental arithmetic in adults.

  12. Adjustment or updating of models

    Indian Academy of Sciences (India)

    D J Ewins

    2000-06-01

    In this paper, first a review of the terminology used in the model adjustment or updating is presented. This is followed by an outline of the major updating algorithms cuurently available, together with a discussion of the advantages and disadvantages of each, and the current state-of-the-art of this important application and part of optimum design technology.

  13. The primordial helium abundance from updated emissivities

    CERN Document Server

    Aver, Erik; Porter, R L; Skillman, Evan D

    2013-01-01

    Observations of metal-poor extragalactic H II regions allow the determination of the primordial helium abundance, Y_p. The He I emissivities are the foundation of the model of the H II region's emission. Porter, Ferland, Storey, & Detisch (2012) have recently published updated He I emissivities based on improved photoionization cross-sections. We incorporate these new atomic data and update our recent Markov Chain Monte Carlo analysis of the dataset published by Izotov, Thuan, & Stasinska (2007). As before, cuts are made to promote quality and reliability, and only solutions which fit the data within 95% confidence level are used to determine the primordial He abundance. The previously qualifying dataset is almost entirely retained and with strong concordance between the physical parameters. Overall, an upward bias from the new emissivities leads to a decrease in Y_p. In addition, we find a general trend to larger uncertainties in individual objects (due to changes in the emissivities) and an increase...

  14. The UCSC Genome Browser database: 2016 update.

    Science.gov (United States)

    Speir, Matthew L; Zweig, Ann S; Rosenbloom, Kate R; Raney, Brian J; Paten, Benedict; Nejad, Parisa; Lee, Brian T; Learned, Katrina; Karolchik, Donna; Hinrichs, Angie S; Heitner, Steve; Harte, Rachel A; Haeussler, Maximilian; Guruvadoo, Luvina; Fujita, Pauline A; Eisenhart, Christopher; Diekhans, Mark; Clawson, Hiram; Casper, Jonathan; Barber, Galt P; Haussler, David; Kuhn, Robert M; Kent, W James

    2016-01-01

    For the past 15 years, the UCSC Genome Browser (http://genome.ucsc.edu/) has served the international research community by offering an integrated platform for viewing and analyzing information from a large database of genome assemblies and their associated annotations. The UCSC Genome Browser has been under continuous development since its inception with new data sets and software features added frequently. Some release highlights of this year include new and updated genome browsers for various assemblies, including bonobo and zebrafish; new gene annotation sets; improvements to track and assembly hub support; and a new interactive tool, the "Data Integrator", for intersecting data from multiple tracks. We have greatly expanded the data sets available on the most recent human assembly, hg38/GRCh38, to include updated gene prediction sets from GENCODE, more phenotype- and disease-associated variants from ClinVar and ClinGen, more genomic regulatory data, and a new multiple genome alignment.

  15. CNGS: Update on secondary beam layout.

    CERN Document Server

    Ball, A E; Falaleev, V P; Grant, A L; Guglielmi, A M; Maire, G; Maugain, J M; Meddahi, M; Palladino, V; Pietropaolo, F; Rangod, Stephane; Sala, P; Vassilopoulos, N; Vincke, H H; CERN. Geneva. SPS and LEP Division

    2000-01-01

    The conceptual technical design of the CNGS (CERN neutrino beam to Gran Sasso) facility has been presented in the report CERN 98-02 / INFN-AE/98-05. An updated beam design, in particular a revised neutrino beam optimised for nu_mu - nu_tau appearance experiments, has been described in an addendum (CERN-SL/99-034(DI) / INFN-AE/99-05). In this note, a slightly modified version of the CNGS secondary beam and an update of the parameter lists is given. The changes aim at technical improvements in the CNGS secondary beam components, without compromising on the expected lifetime of the components. A slight increase of expected nu_tau charged current events at Gran Sasso has been achieved in the simulations.

  16. FEM Updating of the Heritage Court Building Structure

    DEFF Research Database (Denmark)

    Ventura, C. E.; Brincker, Rune; Dascotte, E.

    2001-01-01

    . The starting model of the structure was developed from the information provided in the design documentation of the building. Different parameters of the model were then modified using an automated procedure to improve the correlation between measured and calculated modal parameters. Careful attention......This paper describes results of a model updating study conducted on a 15-storey reinforced concrete shear core building. The output-only modal identification results obtained from ambient vibration measurements of the building were used to update a finite element model of the structure...... was placed to the selection of the parameters to be modified by the updating software in order to ensure that the necessary changes to the model were realistic and physically realisable and meaningful. The paper highlights the model updating process and provides an assessment of the usefulness of using...

  17. Second-generation speed limit map updating applications

    DEFF Research Database (Denmark)

    Tradisauskas, Nerius; Agerholm, Niels; Juhl, Jens

    2011-01-01

    Intelligent Speed Adaptation is an Intelligent Transport System developed to significantly improve road safety in helping car drivers maintain appropriate driving behaviour. The system works in connection with the speed limits on the road network. It is thus essential to keep the speed limit map...... developed to give road authorities the opportunity to keep the speed limit map updated. However, the feedback from road authorities was insufficient. Hence a new web application based on Google Maps was made to provide easier speed limit updates for road authorities. The lessons learnt were that tools...... for map updating should preferably be made on the basis of a commercial map provider, 2 such as Google Maps and that the real challenge is to oblige road authorities to carry out updates....

  18. Amblyopia update: new treatments.

    Science.gov (United States)

    Vagge, Aldo; Nelson, Leonard B

    2016-09-01

    This review article is an update on the current treatments for amblyopia. In particular, the authors focus on the concepts of brain plasticity and their implications for novel treatment strategies for both children and adults affected by amblyopia. A variety of strategies has been developed to treat amblyopia in children and adults. New evidence on the pathogenesis of amblyopia has been obtained both in animal models and in clinical trials. Mainly, these studies have challenged the classical concept that amblyopia becomes untreatable after the 'end' of the sensitive or critical period of visual development, because of a lack of sufficient plasticity in the adult brain. New treatments for amblyopia in children and adults are desirable and should be encouraged. However, further studies should be completed before such therapies are widely accepted into clinical practice.

  19. Update on Parkinson disease.

    Science.gov (United States)

    Siderowf, Andrew; Stern, Matthew

    2003-04-15

    This Update reviews developments in the pathophysiology and treatment of Parkinson disease during the past several years. In the area of pathophysiology, studies have addressed the contribution of environmental factors such as caffeine and pesticides. Large-scale epidemiologic studies have also expanded the role genetic factors are thought to play. Detailed studies of kindreds with familial Parkinson disease due to alpha-synuclein and parkin have catalyzed basic science investigations into the pathologic mechanisms of the disease. These studies have led to the development of a pathophysiologic model of Parkinson disease that emphasizes abnormal protein aggregation. Studies of treatment have clarified the relative roles of l-dopa and dopamine agonists in early Parkinson disease and shown the potential for surgical interventions, particularly deep-brain stimulation, to relieve the symptoms of advanced, medically refractory disease.

  20. Y2K UPDATE

    CERN Multimedia

    Sverre JARP

    1999-01-01

    Concerning Y2K preparation, please note the following:Everybody, who has a NICE installation on his/her PC, needs to log in to NICE at least once before Xmas to get the Y2K update installed. This applies especially to dual boot systems.The test schedule on Y2Kplus.cern.ch will be prolonged. The last restart took place on 10 November and two more will take place on 24 November and 8 December, respectively. The Oracle users responsible for the maintenance of Oracle Forms applications which include PL/SQL blocks where date fields are handled with the default format are requested to contact oracle.support@cern.ch at their earliest convenience.Sverre Jarp (CERN Y2K co-ordinator, phone: 74944)

  1. ILRS Website Update

    Science.gov (United States)

    Noll, Carey E.; Torrence, Mark H.; Pollack, Nathan H.; Tyahla, Lori J.

    2013-01-01

    The ILRS website, http://ilrs.gsfc.nasa.gov, is the central source of information for all aspects of the service. The website provides information on the organization and operation of the ILRS and descriptions of ILRS components data, and products. Furthermore, the website provides an entry point to the archive of these data products available through the data centers. Links are provided to extensive information on the ILRS network stations including performance assesments and data quality evaluations. Descriptions of suported satellite missions (current, future, and past) are provided to aid in station acquisition and data analysis. The website was reently redesigned. Content was reviewed during the update process, ensuring information is current and useful. This poster will provide specific examples of key sections, applicaitons, and webpages.

  2. Normal response function method for mass and stiffness matrix updating using complex FRFs

    Science.gov (United States)

    Pradhan, S.; Modak, S. V.

    2012-10-01

    Quite often a structural dynamic finite element model is required to be updated so as to accurately predict the dynamic characteristics like natural frequencies and the mode shapes. Since in many situations undamped natural frequencies and mode shapes need to be predicted, it has generally been the practice in these situations to seek updating of only mass and stiffness matrix so as to obtain a reliable prediction model. Updating using frequency response functions (FRFs) has been one of the widely used approaches for updating, including updating of mass and stiffness matrices. However, the problem with FRF based methods, for updating mass and stiffness matrices, is that these methods are based on use of complex FRFs. Use of complex FRFs to update mass and stiffness matrices is not theoretically correct as complex FRFs are not only affected by these two matrices but also by the damping matrix. Therefore, in situations where updating of only mass and stiffness matrices using FRFs is required, the use of complex FRFs based updating formulation is not fully justified and would lead to inaccurate updated models. This paper addresses this difficulty and proposes an improved FRF based finite element model updating procedure using the concept of normal FRFs. The proposed method is a modified version of the existing response function method that is based on the complex FRFs. The effectiveness of the proposed method is validated through a numerical study of a simple but representative beam structure. The effect of coordinate incompleteness and robustness of method under presence of noise is investigated. The results of updating obtained by the improved method are compared with the existing response function method. The performance of the two approaches is compared for cases of light, medium and heavily damped structures. It is found that the proposed improved method is effective in updating of mass and stiffness matrices in all the cases of complete and incomplete data and

  3. Update of CERN exchange network

    CERN Multimedia

    2003-01-01

    An update of the CERN exchange network will be done next April. Disturbances or even interruptions of telephony services may occur from 4th to 24th April during evenings from 18:30 to 00:00 but will not exceed more than 4 consecutive hours (see tentative planning below). CERN divisions are invited to avoid any change requests (set-ups, move or removals) of telephones and fax machines from 4th to 25th April. Everything will be done to minimize potential inconveniences which may occur during this update. There will be no loss of telephone functionalities. CERN GSM portable phones won't be affected by this change. Should you need more details, please send us your questions by email to Standard.Telephone@cern.ch. DateChange typeAffected areas April 11 Update of switch in LHC 4 LHC 4 Point April 14 Update of switch in LHC 5 LHC 5 Point April 15 Update of switches in LHC 3 and LHC 2 Points LHC 3 and LHC 2 April 22 Update of switch N4 Meyrin Ouest April 23 Update of switch  N6 Prévessin Site Ap...

  4. Integration of a Star Tracker and Inertial Sensors Using an Attitude Update

    Science.gov (United States)

    2014-09-18

    GPS, star tracker, and barometer . GPS measurements are used to update the INS position and velocity for a small duration in the beginning of the...vehicle’s flight time. Star tracker and barometer measurements are used to update the INS attitude and altitude, respectively. This research uses a...and barometer bias) using the three types of measurement updates. The simulation results show that the star tracker was able to improve the performance

  5. Extraglottic airway devices: technology update

    Directory of Open Access Journals (Sweden)

    Sharma B

    2017-08-01

    Full Text Available Bimla Sharma, Chand Sahai, Jayashree Sood Department of Anaesthesiology, Pain and Perioperative Medicine, Sir Ganga Ram Hospital, New Delhi, India Abstract: Extraglottic airway devices (EADs have revolutionized the field of airway management. The invention of the laryngeal mask airway was a game changer, and since then, there have been several innovations to improve the EADs in design, functionality, safety and construction material. These have ranged from changes in the shape of the mask, number of cuffs and material used, like rubber, polyvinylchloride and latex. Phthalates, which were added to the construction material in order to increase device flexibility, were later omitted when this chemical was found to have serious adverse reproductive outcomes. The various designs brought out by numerous companies manufacturing EADs resulted in the addition of several devices to the airway market. These airway devices were put to use, many of them with inadequate or no evidence base regarding their efficacy and safety. To reduce the possibility of compromising the safety of the patient, the Difficult Airway Society (DAS formed the Airway Device Evaluation Project Team (ADEPT to strengthen the evidence base for airway equipment and vet the new extraglottic devices. A preuse careful analysis of the design and structure may help in better understanding of the functionality of a particular device. In the meantime, the search for the ideal EAD continues. Keywords: extraglottic airway devices, laryngeal mask airway, other extraglottic airway devices, safety, technology update

  6. Congenital Chagas disease: an update.

    Science.gov (United States)

    Carlier, Yves; Sosa-Estani, Sergio; Luquetti, Alejandro O; Buekens, Pierre

    2015-05-01

    Congenital infection with Trypanosoma cruzi is a global problem, occurring on average in 5% of children born from chronically infected mothers in endemic areas, with variations depending on the region. This presentation aims to focus on and update epidemiological data, research methods, involved factors, control strategy and possible prevention of congenital infection with T. cruzi. Considering that etiological treatment of the child is always effective if performed before one year of age, the diagnosis of infection in pregnant women and their newborns has to become the standard of care and integrated into the surveillance programs of syphilis and human immunodeficiency virus. In addition to the standard tests, polymerase chain reaction performed on blood of neonates of infected mothers one month after birth might improve the diagnosis of congenital infection. Recent data bring out that its transmission can be prevented through treatment of infected women before they become pregnant. The role of parasite genotypes and host genetic factors in parasite transmission and development of infection in foetuses/neonates has to be more investigated in order to better estimate the risk factors and impact on health of congenital infection with T. cruzi.

  7. Congenital Chagas disease: an update

    Directory of Open Access Journals (Sweden)

    Yves Carlier

    2015-05-01

    Full Text Available Congenital infection with Trypanosoma cruzi is a global problem, occurring on average in 5% of children born from chronically infected mothers in endemic areas, with variations depending on the region. This presentation aims to focus on and update epidemiological data, research methods, involved factors, control strategy and possible prevention of congenital infection with T. cruzi. Considering that etiological treatment of the child is always effective if performed before one year of age, the diagnosis of infection in pregnant women and their newborns has to become the standard of care and integrated into the surveillance programs of syphilis and human immunodeficiency virus. In addition to the standard tests, polymerase chain reaction performed on blood of neonates of infected mothers one month after birth might improve the diagnosis of congenital infection. Recent data bring out that its transmission can be prevented through treatment of infected women before they become pregnant. The role of parasite genotypes and host genetic factors in parasite transmission and development of infection in foetuses/neonates has to be more investigated in order to better estimate the risk factors and impact on health of congenital infection with T. cruzi.

  8. Vasectomy reversal: a clinical update

    Directory of Open Access Journals (Sweden)

    Abhishek P Patel

    2016-01-01

    Full Text Available Vasectomy is a safe and effective method of contraception used by 42-60 million men worldwide. Approximately 3%-6% of men opt for a vasectomy reversal due to the death of a child or divorce and remarriage, change in financial situation, desire for more children within the same marriage, or to alleviate the dreaded postvasectomy pain syndrome. Unlike vasectomy, vasectomy reversal is a much more technically challenging procedure that is performed only by a minority of urologists and places a larger financial strain on the patient since it is usually not covered by insurance. Interest in this procedure has increased since the operating microscope became available in the 1970s, which consequently led to improved patency and pregnancy rates following the procedure. In this clinical update, we discuss patient evaluation, variables that may influence reversal success rates, factors to consider in choosing to perform vasovasostomy versus vasoepididymostomy, and the usefulness of vasectomy reversal to alleviate postvasectomy pain syndrome. We also review the use of robotics for vasectomy reversal and other novel techniques and instrumentation that have emerged in recent years to aid in the success of this surgery.

  9. Updating neutrino magnetic moment constraints

    Directory of Open Access Journals (Sweden)

    B.C. Cañas

    2016-02-01

    Full Text Available In this paper we provide an updated analysis of the neutrino magnetic moments (NMMs, discussing both the constraints on the magnitudes of the three transition moments Λi and the role of the CP violating phases present both in the mixing matrix and in the NMM matrix. The scattering of solar neutrinos off electrons in Borexino provides the most stringent restrictions, due to its robust statistics and the low energies observed, below 1 MeV. Our new limit on the effective neutrino magnetic moment which follows from the most recent Borexino data is 3.1×10−11μB at 90% C.L. This corresponds to the individual transition magnetic moment constraints: |Λ1|≤5.6×10−11μB, |Λ2|≤4.0×10−11μB, and |Λ3|≤3.1×10−11μB (90% C.L., irrespective of any complex phase. Indeed, the incoherent admixture of neutrino mass eigenstates present in the solar flux makes Borexino insensitive to the Majorana phases present in the NMM matrix. For this reason we also provide a global analysis including the case of reactor and accelerator neutrino sources, presenting the resulting constraints for different values of the relevant CP phases. Improved reactor and accelerator neutrino experiments will be needed in order to underpin the full profile of the neutrino electromagnetic properties.

  10. Multiplicative updates for the LASSO

    DEFF Research Database (Denmark)

    Mørup, Morten; Clemmensen, Line Katrine Harder

    2007-01-01

    .e. least squares minimization with $L_1$-norm regularization, since the multiplicative updates (MU) can efficiently exploit the structure of the problem traditionally solved using quadratic programming (QP). We derive an algorithm based on MU for the LASSO and compare the performance to Matlabs standard QP......Multiplicative updates have proven useful for non-negativity constrained optimization. Presently, we demonstrate how multiplicative updates also can be used for unconstrained optimization. This is for instance useful when estimating the least absolute shrinkage and selection operator (LASSO), i...

  11. Updated science systems on USCGC Healy

    Science.gov (United States)

    Chayes, D. N.; Roberts, S. D.; Arko, R. A.; Hiller, S. M.

    2008-12-01

    The USCG cutter Healy is the U.S. Arctic research icebreaker. Prior to the 2008 season, a number of upgrades and improvements were made to the science systems. These included the addition of two Bell BGM-3 marine gravity meters. The vessel's existing meterological sensors were enhanced with two RM Young model 85004 heated ultrasonic anemometers; a Paroscientific, Inc. model "MET-3A" air temperature, humidity and barometric pressure subsystem; and an RM Young model 50202 heated rain gauge. The flow through sea water system was updated with new flow meters, a SeaBird SBE45 thermosalinograph, long and a short wave radiation sensors, a Seapoint fluorometer. A Milltech Marine Smart Radio model SR161 Automatic Identification System (AIS) receiver and an updated interface to real-time winch and wire performance have been added. Our onboard real-time GIS has been updated to include real-time plotting of other ship tracks from our AIS receiver and the ability for users to save and share planned tracks. For the HLY0806 leg, we implemented a SWAP ship-to ship wireless connection for our two-ship operations with the Canadian icebreaker Louis S. St. Laurent similar to the one we implemented for our two-ship program with the Swedish icebreaker Oden in 2005. We updated our routine delivery of underway data to investigators, as well as a copy for archiving to the NSF-supported Marine Geoscience Data System (MGDS), using portable "boomerang" drives. An end-user workstation was added to accommodate increasing demand for onboard processing. Technical support for science on the Healy is supported by the U.S. National Science Foundation.

  12. Update in Internal Medicine

    Science.gov (United States)

    López-Jiménez, Francisco; Brito, Máximo; Aude, Y. Wady; Scheinberg, Phillip; Kaplan, Mariana; Dixon, Denise A.; Schneiderman, Neil; Trejo, Jorge F.; López-Salazar, Luis Humberto; Ramírez-Barba, Ector Jaime; Kalil, Roberto; Ortiz, Carmen; Goyos, José; Buenaño, Alvaro; Kottiech, Samer; Lamas, Gervasio A.

    2009-01-01

    More than 500,000 new medical articles are published every year and available time to keep updated is scarcer every day. Nowadays, the task of selecting useful, consistent, and relevant information for clinicians is a priority in many major medical journals. This review has the aim of gathering the results of the most important findings in clinical medicine in the last few years. It is focused on results from randomized clinical trials and well-designed observational research. Findings were included preferentially if they showed solid results, and we avoided as much as possible including only preliminary data, or results that included only non-clinical outcomes. Some of the most relevant findings reported here include the significant benefit of statins in patients with coronary artery disease even with mean cholesterol level. It also provides a substantial review of the most significant trials assessing the effectiveness of IIb/IIIa receptor blockers. In gastroenterology many advances have been made in the H. pylori eradication, and the finding that the cure of H. pylori infection may be followed by gastroesophageal reflux disease. Some new antivirals have shown encouraging results in patients with chronic hepatitis. In the infectious disease arena, the late breaking trials in anti-retroviral disease are discussed, as well as the new trends regarding antibiotic resistance. This review approaches also the role of leukotriene modifiers in the treatment of asthma and discusses the benefit of using methylprednisolone in patients with adult respiratory distress syndrome, among many other advances in internal medicine. PMID:11068074

  13. Advanced Stirling Convertor Update

    Science.gov (United States)

    Wood, J. Gary; Carroll, Cliff; Matejczyk, Dan; Penswick, L. B.; Soendker, E.

    2006-01-01

    This paper reports on the 88 We Advanced Stirling Convertor (ASC) currently being developed under Phase II of a NASA NRA program for possible use in advanced high specific power radioisotope space power systems. An early developmental unit, the Frequency Test Bed (FTB) which was built and tested in Phase I demonstrated 36% efficiency. The ASC-1 currently being developed under Phase II, uses a high temperature heater head to allow for operation at 850 °C and is expected to have an efficiency approaching 40% (based on AC electrical out) at a temperature ratio of 3.1. The final lightweight ASC-2 convertor to be developed in Phase III is expected to have a mass of approximately 1 kg. The implementation of the ASC would allow for much higher specific power radioisotope power systems, requiring significantly less radioisotope fuel than current systems. The first run of the ASC-1 occurred in September 2005, and full temperature operation was achieved in early October 2005. Presented is an update on progress on the ASC program as well as the plans for future development. Also presented are efforts being performed to ensure the ASC has the required long life already demonstrated in free-piston Stirling cryocoolers.

  14. Updating risk prediction tools: a case study in prostate cancer.

    Science.gov (United States)

    Ankerst, Donna P; Koniarski, Tim; Liang, Yuanyuan; Leach, Robin J; Feng, Ziding; Sanda, Martin G; Partin, Alan W; Chan, Daniel W; Kagan, Jacob; Sokoll, Lori; Wei, John T; Thompson, Ian M

    2012-01-01

    Online risk prediction tools for common cancers are now easily accessible and widely used by patients and doctors for informed decision-making concerning screening and diagnosis. A practical problem is as cancer research moves forward and new biomarkers and risk factors are discovered, there is a need to update the risk algorithms to include them. Typically, the new markers and risk factors cannot be retrospectively measured on the same study participants used to develop the original prediction tool, necessitating the merging of a separate study of different participants, which may be much smaller in sample size and of a different design. Validation of the updated tool on a third independent data set is warranted before the updated tool can go online. This article reports on the application of Bayes rule for updating risk prediction tools to include a set of biomarkers measured in an external study to the original study used to develop the risk prediction tool. The procedure is illustrated in the context of updating the online Prostate Cancer Prevention Trial Risk Calculator to incorporate the new markers %freePSA and [-2]proPSA measured on an external case-control study performed in Texas, U.S.. Recent state-of-the art methods in validation of risk prediction tools and evaluation of the improvement of updated to original tools are implemented using an external validation set provided by the U.S. Early Detection Research Network.

  15. Structural Dynamics Model Updating with Positive Definiteness and No Spillover

    Directory of Open Access Journals (Sweden)

    Yongxin Yuan

    2014-01-01

    Full Text Available Model updating is a common method to improve the correlation between structural dynamics models and measured data. In conducting the updating, it is desirable to match only the measured spectral data without tampering with the other unmeasured and unknown eigeninformation in the original model (if so, the model is said to be updated with no spillover and to maintain the positive definiteness of the coefficient matrices. In this paper, an efficient numerical method for updating mass and stiffness matrices simultaneously is presented. The method first updates the modal frequencies. Then, a method is presented to construct a transformation matrix and this matrix is used to correct the analytical eigenvectors so that the updated model is compatible with the measurement of the eigenvectors. The method can preserve both no spillover and the symmetric positive definiteness of the mass and stiffness matrices. The method is computationally efficient as neither iteration nor numerical optimization is required. The numerical example shows that the presented method is quite accurate and efficient.

  16. Gearbox Reliability Collaborative Update (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Sheng, S.; Keller, J.; Glinsky, C.

    2013-10-01

    This presentation was given at the Sandia Reliability Workshop in August 2013 and provides information on current statistics, a status update, next steps, and other reliability research and development activities related to the Gearbox Reliability Collaborative.

  17. Email Updates: MedlinePlus

    Science.gov (United States)

    ... of this page: https://medlineplus.gov/listserv.html Email Updates To use the sharing features on this ... view your email history or unsubscribe. Prevent MedlinePlus emails from being marked as "spam" or "junk" To ...

  18. 77 FR 13198 - Product List Update

    Science.gov (United States)

    2012-03-06

    ...] Product List Update AGENCY: Postal Regulatory Commission. ACTION: Final rule. SUMMARY: The Commission is... adopted in a recent Commission order. The referenced policy assumes periodic updates. The updates are... these updates. DATES: Effective Date: March 6, 2012. Applicability Dates: February 23, 2012...

  19. 75 FR 39629 - FOIA Fee Schedule Update

    Science.gov (United States)

    2010-07-12

    ... 1703 FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Establishment of... Information Act (FOIA) Fee Schedule Update pursuant to 10 CFR 1703.107(b)(6) of the Board's regulations. DATES... update the FOIA Fee Schedule once every 12 months. The previous Fee Schedule Update was published in...

  20. Communication technology update and fundamentals

    CERN Document Server

    Grant, August E

    2008-01-01

    New communication technologies are being introduced at an astonishing rate. Making sense of these technologies is increasingly difficult. Communication Technology Update is the single best source for the latest developments, trends, and issues in communication technology. Now in its 11th edition, Communication Technology Update has become an indispensable information resource for business, government, and academia. As always, every chapter has been completely rewritten to reflect the latest developments and market statistics, and now covers mobile computing, dig

  1. Communication technology update and fundamentals

    CERN Document Server

    Grant, August E

    2010-01-01

    New communication technologies are being introduced at an astonishing rate. Making sense of these technologies is increasingly difficult. Communication Technology Update and Fundamentals is the single best source for the latest developments, trends, and issues in communication technology. Featuring the fundamental framework along with the history and background of communication technologies, Communication Technology Update and Fundamentals, 12th edition helps you stay ahead of these ever-changing and emerging technologies.As always, every chapter ha

  2. Episodic fieldwork, updating, and sociability

    DEFF Research Database (Denmark)

    Whyte, M.

    2013-01-01

    on these relationships. I draw on Simmel's concept of sociability to explore the significance of the recurring updates that are so much a part of long-term and thus episodic fieldwork. Updating suggests participation, positionality, and transformation-as well as play and familiarity. The presumption of familiarity......, which is at the heart of sociability, becomes a tool for exploring time and new social experiences and the ways in which chronology is interwoven with shifting social positions....

  3. 一种用于流固耦合分析的有限元网格简捷更新方法%Improved Finite Element Mesh Update Method for Fluid-Structure Interaction Analysis

    Institute of Scientific and Technical Information of China (English)

    苏波; 钱若军; 韩向科

    2011-01-01

    针对流固耦合分析中的移动边界问题,在拟固体二步法的基础上,提出一种新的有限元网格更新方法:第一步(预测步),将流体网格作为指定位移边界条件下的拟固体,进行线弹性分析;第二步(校正步),根据第一步计算得到的应变场,采用主剪应变方法,赋予主剪应变较大的单元以较大的杨氏模量,对所构造的非均质固体进行运动分析,得到理想的更新网格.采用不同算法对不同运动类型(包括平动、转动、变形)和不同运动幅度下的二维、三维网格运动进行计算,结果表明:与一步法和ChiandUssi法相比,文中提出的方法具有较强的适用性,能显著地减小单元的畸变,使网格保持优良的计算性能,适用于大变形流固耦合问题中的网格更新计算.%Based on the pseudo-solid two-step (PSTS) model, a new mesh update method-PSS-PSTS method is proposed to solve moving boundary problems for fluid-structure interaction analysis. In the first step (predictor), a linear pseudo-solid model is first conducted to the fluid mesh subjected to prescribed displacement boundary. In the second step (corrector), based on the strain field computed in the first step, PSS (principal shear strain) method endows the element with greater Young modulus due to its larger principal shear strain, then the motion of the established non-homogeneous solid model is computed and taken as the desired fluid update mesh.Some examples of 2D/3D FEM mesh update under different motion types (translation, rotation and deformation) and different motion scale computed by PSS-PSTS method are studied. The results show that the PSS-PSTS method is highly effective in preventing extremely distorted elements and makes the mesh maintain high computation quality compared with the one-step method and the two-step methods proposed by Chiandussi. It can be used for mesh update computation for fluid-structure interaction problems with large deformation.

  4. Novel therapies in genitourinary cancer: an update

    Directory of Open Access Journals (Sweden)

    Wu Shenhong

    2008-08-01

    Full Text Available Abstract In recent years, new treatment for renal cell carcinoma (RCC has been a spotlight in the field of cancer therapeutics. With several emerging agents branded as 'targeted therapy' now available, both medical oncologists and urologists are progressively more hopeful for better outcomes. The new remedies may provide patients with improved survival and at the same time less toxicity when compared to traditional cytotoxic agents. This article will center on current and emerging treatment strategies for advanced RCC and other GU malignancies with updates from 2008 annual ASCO meeting.

  5. Autoimmune pancreatitis. An update; Autoimmunpankreatitis. Ein Update

    Energy Technology Data Exchange (ETDEWEB)

    Helmberger, T. [Klinikum Bogenhausen, Staedt. Klinikum, Institut fuer Diagnostische und Interventionelle Radiologie, Neuroradiologie und Nuklearmedizin, Muenchen (Germany)

    2016-04-15

    Autoimmune pancreatitis (AIP) is a rare disease, the pathophysiological understanding of which has been greatly improved over the last years. The most common form, type 1 AIP belongs to the IgG4-related diseases and must be distinguished from type 2 AIP, which is a much rarer entity associated with chronic inflammatory bowel disease. Clinically, there is an overlap with pancreatic cancer. Imaging and further criteria, such as serological and histological parameters are utilized for a differentiation between both entities in order to select the appropriate therapy and to avoid the small but ultimately unnecessary number of pancreatectomies. The diagnostics of AIP are complex, whereby the consensus criteria of the International Association of Pancreatology have become accepted as the parameters for discrimination. These encompass five cardinal criteria and one therapeutic criterion. By applying these criteria AIP can be diagnosed with a sensitivity of 84.9 %, a specificity of 100 % and an accuracy of 93.8 %. The diagnosis of AIP is accomplished by applying several parameters of which two relate to imaging. As for the routine diagnostics of the pancreas these are ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI). Important for the differential diagnosis is the exclusion of signs of local and remote tumor spread for which CT and MRI are established. The essential diagnostic parameter of histology necessitates sufficient sample material, which cannot usually be acquired by a fine needle biopsy. CT or MRI are the reference standard methods for identification of the optimal puncture site and imaging-assisted (TruCut) biopsy. In patients presenting with unspecific upper abdominal pain, painless jaundice combined with the suspicion of a pancreatic malignancy in imaging but a mismatch of secondary signs of malignancy, AIP should also be considered as a differential diagnosis. As the diagnosis of AIP only partially relies on imaging radiologists also

  6. Space Shuttle development update

    Science.gov (United States)

    Brand, V.

    1984-01-01

    The development efforts, since the STS-4 flight, in the Space Shuttle (SS) program are presented. The SS improvements introduced in the last two years include lower-weight loads, communication through the Tracking and Data Relay Satellite, expanded extravehicular activity capability, a maneuvering backpack and the manipulator foot restraint, the improvements in thermal projection system, the 'optional terminal area management targeting' guidance software, a rendezvous system with radar and star tracker sensors, and improved on-orbit living conditions. The flight demonstrations include advanced launch techniques (e.g., night launch and direct insertion to orbit); the on-orbit demonstrations; and added entry and launching capabilities. The entry aerodynamic analysis and entry flight control fine tuning are described. Reusability, improved ascent performance, intact abort and landing flexibility, rollout control, and 'smart speedbrakes' are among the many improvements planned for the future.

  7. High-dose neutron detector project update

    Energy Technology Data Exchange (ETDEWEB)

    Menlove, Howard Olsen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Henzlova, Daniela [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-08-10

    These are the slides for a progress review meeting by the sponsor. This is an update on the high-dose neutron detector project. In summary, improvements in both boron coating and signal amplification have been achieved; improved boron coating materials and procedures have increase efficiency by ~ 30-40% without the corresponding increase in the detector plate area; low dead-time via thin cell design (~ 4 mm gas gaps) and fast amplifiers; prototype PDT 8” pod has been received and testing is in progress; significant improvements in efficiency and stability have been verified; use commercial PDT 10B design and fabrication to obtain a faster path from the research to practical high-dose neutron detector.

  8. High-dose neutron detector project update

    Energy Technology Data Exchange (ETDEWEB)

    Menlove, Howard Olsen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Henzlova, Daniela [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-08-10

    These are the slides for a progress review meeting by the sponsor. This is an update on the high-dose neutron detector project. In summary, improvements in both boron coating and signal amplification have been achieved; improved boron coating materials and procedures have increased efficiency by ~ 30-40% without the corresponding increase in the detector plate area; low dead-time via thin cell design (~ 4 mm gas gaps) and fast amplifiers; prototype PDT 8” pod has been received and testing is in progress; significant improvements in efficiency and stability have been verified; use commercial PDT 10B design and fabrication to obtain a faster path from the research to practical high-dose neutron detector.

  9. Three Case Studies in Finite Element Model Updating

    Directory of Open Access Journals (Sweden)

    M. Imregun

    1995-01-01

    Full Text Available This article summarizes the basic formulation of two well-established finite element model (FEM updating techniques for improved dynamic analysis, namely the response function method (RFM and the inverse eigensensitivity method (IESM. Emphasis is placed on the similarities in their mathematical formulation, numerical treatment, and on the uniqueness of the resulting updated models. Three case studies that include welded L-plate specimens, a car exhaust system, and a highway bridge were examined in some detail and measured vibration data were used throughout the investigation. It was experimentally observed that significant dynamic behavior discrepancies existed between some of the nominally identical structures, a feature that makes the task of model updating even more difficult because no unequivocal reference data exist in this particular case. Although significant improvements were obtained in all cases where the updating of the FE model was possible, it was found that the success of the updated models depended very heavily on the parameters used, such as the selection and number of the frequency points for RFM, and the selection of modes and the balancing of the sensitivity matrix for IESM. Finally, the performance of the two methods was compared from general applicability, numerical stability, and computational effort standpoints.

  10. Dutch Venous Ulcer guideline update.

    Science.gov (United States)

    Maessen-Visch, M Birgitte; de Roos, Kees-Peter

    2014-05-01

    The revised guideline of 2013 is an update of the 2005 guideline "venous leg ulcer". In this special project four separate guidelines (venous leg ulcer, varicose veins, compression therapy and deep venous disorders) were revised and developed simultaneously. A meeting was held including representatives of any organisation involved in venous disease management including patient organizations and health insurance companies. Eighteen clinical questions where defined, and a new strategy was used to accelerate the process. This resulted in two new and two revised guidelines within one year. The guideline committee advises use of the C of the CEAP classification as well as the Venous Clinical Severity Score (VCSS) and a Quality of life (QoL) score in the assessment of clinical signs. These can provide insight into the burden of disease and the effects of treatment as experienced by the patient. A duplex ultrasound should be performed in every patient to establish the underlying aetiology and to evaluate the need for treatment (which is discussed in a separate guideline). The use of the TIME model for describing venous ulcers is recommended. There is no evidence for antiseptic or antibiotic wound care products except for a Cochrane review in which some evidence is presented for cadexomer iodine. Signs of infection are the main reason for the use of oral antibiotics. When the ulcer fails to heal the use of oral aspirin and pentoxifylline can be considered as an adjunct. For the individual patient, the following aspects should be considered: the appearance of the ulcer (amount of exudate) according to the TIME model, the influence of wound care products on moisturising the wound, frequency of changing compression bandages, pain and allergies. The cost of the dressings should also be considered. Education and training of patients t improves compliance with compression therapy but does not influence wound healing rates.

  11. Obesity management: Update on orlistat

    Directory of Open Access Journals (Sweden)

    Belinda S Drew

    2008-01-01

    Full Text Available Belinda S Drew, Andrew F Dixon, John B DixonCentre for Obesity Research and Education, Monash University, Melbourne, AustraliaAbstract: Over the past 20 years obesity has become a worldwide concern of frightening proportion. The World Health Organization estimates that there are over 400 million obese and over 1.6 billion overweight adults, a figure which is projected to almost double by 2015. This is not a disease restricted to adults – at least 20 million children under the age of 5 years were overweight in 2005 (WHO 2006. Overweight and obesity lead to serious health consequences including coronary artery disease, stroke, type-2 diabetes, heart failure, dyslipidemia, hypertension, reproductive and gastrointestinal cancers, gallstones, fatty liver disease, osteoarthritis and sleep apnea (Padwal et al 2003.Modest weight loss in the obese of between 5% and 10% of bodyweight is associated with improvements in cardiovascular risk profiles and reduced incidence of type 2 diabetes (Goldstein 1992; Avenell et al 2004; Padwal and Majumdar 2007. Orlistat, a gastric and pancreatic lipase inhibitor that reduces dietary fat absorption by approximately 30%, has been approved for use for around ten years (Zhi et al 1994; Hauptman 2000. There is now a growing body of evidence to suggest that Orlistat assists weight loss and that it may also have additional benefits. The aim of this review is to provide a brief update on the current literature studying the efficacy, safety and significance of the use of Orlistat in clinical practice.Keywords: obese, weight, diet, orlistat, hypertension, cholesterol

  12. VIIP 2017 Clinical Update

    Science.gov (United States)

    Tarver, William

    2017-01-01

    INTRODUCTION: NASA's Space Medicine community knowledge regarding the "Vision Impairment Intracranial Pressure", or VIIP.has been evolving over time.. Various measures of occupational health related to this condition had to be determined and then plans/processes put into place. The most robust of these processes were inititated in 2010. This presentation will provide a clinic update of the astronaut occupational health data related to VIIP. METHODS: NASA and its international partners require its astronauts to undergo routine health measures deemed important to monitoring VIIP. The concern is that the spaceflight environment aboard ISS could cause some astronauts to have physiologic changes detrimental to either ongoing mission operations or long-term health related to the ocular system and possibly the CNS. Specific medical tests include but are not limited to brain/orbit MRI (NASA unique protocol), OCT, fundoscopy and ocular ultrasound. Measures are taken prior to spaceflight, in-flight and post-flight. Measures to be reported include incidence of disc edema, globe flattening, choroidal folds, ONSD and change in refractive error. RESULTS: 73 ISS astronauts have been evaluated at least partially for VIIP related measures. Of these individuals, approximately 1 in 7 have experienced disc edema. The prevalence of the other findings is more complicated as the medical testing has changed over time. Overall, 26 separate individuals have experienced at least one of the findings NASA has associated with VIIP Another confounding factor is most of the astronauts have prior spaceflight experience at the time of the "pre-flight" testing. DISCUSSION: In 2010 NASA and its US operating segment (USOS) partners (CSA, ESA and JAXA) began routine occupational monitoring and data collection for most VIIP related changes. Interpretation of that data is extremely challenging for several reasons. For example, the determination of disc edema is the most complete finding as we have had

  13. Atrial-focused views improve the accuracy of two-dimensional echocardiographic measurements of the left and right atrial volumes: a contribution to the increase in normal values in the guidelines update.

    Science.gov (United States)

    Kebed, Kalie; Kruse, Eric; Addetia, Karima; Ciszek, Boguslawa; Thykattil, Minnie; Guile, Brittney; Lang, Roberto M; Mor-Avi, Victor

    2017-02-01

    Current guidelines recommend that the atria be measured in 2D echocardiographic (2DE) apical views using the method-of-disks (MOD) or area-length (AL) technique as an alternative, although no definitive data exists that these are interchangeable. However, standard apical views maximize the long-axis of the left ventricle, rather than the dimensions of the atria, resulting in atrial foreshortening. We hypothesized that the increase in normal values of atrial volumes in the recent guidelines update was driven by data obtained using either the AL technique or dedicated atrial-focused views, which maximize the longitudinal dimension of the atria and thus provide larger volumes than the MOD measurements in standard apical views. We prospectively studied 30 patients (Philips iE33) to compare 2DE measurements of left and right atrial volumes (LAV, RAV) using the MOD and AL techniques in standard and atrial-focused views, against 3D echocardiography (3DE) derived volumes (QLab) as a reference. Compared to standard views, atrial-focused views provided significantly larger MOD volumes for both atria, which were in better agreement with 3DE, as reflected by higher correlation coefficients (LAV: r = 0.95 vs. 0.89; RAV: r = 0.89 vs. 0.84), smaller biases (LAV: -1 ml vs. 7 ml; RAV: 3 ml vs. 7 ml) and tighter limits of agreement. This was also the case for the AL measurements, which were minimally larger than the MOD values (NS) for both atria. In conclusion, atrial-focused views are a more accurate alternative to standard apical views, which provides larger volumes. This finding can explain the increase in the normal values in the recent guidelines update, which was mostly driven by the use of atrial-focused views, rather than by the differences between MOD and AL techniques. This understanding is essential in order to correctly integrate the revised normal values into clinical practice.

  14. 2011 Residential Energy Efficiency Technical Update Meeting Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2011-11-01

    This report provides an overview of the U.S. Department of Energy Building America program's Summer 2011 Residential Energy Efficiency Technical Update Meeting. This meeting was held on August 9-11, 2011, in Denver, Colorado, and brought together more than 290 professionals representing organizations with a vested interest in energy efficiency improvements in residential buildings.

  15. Allo-Hematopoietic Stem Cell Transplant in China: 2014 Update.

    Science.gov (United States)

    Lv, Meng; Huang, Xiao-Jun

    2014-01-01

    Allogeneic hematopoietic stem cell transplantation (allo-HSCT) provides powerful curative weapons for patients with certain hematological diseases. Great improvements have been made within recent years, particularly in the fields of haploidentical HSCT, allo-HSCT for aplastic anemia, and strategies to overcome relapse and graft versus host disease. This review updates the current state of allo-HSCT in China.

  16. Animal Science Update Programs--The Role of Teacher Educators.

    Science.gov (United States)

    Osborne, Ed; And Others

    1986-01-01

    Agricultural teachers must continually improve their knowledge and skills in animal science. Teacher educators can play a significant role in this process through the following channels: summer courses, teleconferencing, workshops, summer internships, technical update programs, field days, curriculum materials development and dissemination, and…

  17. Update on Validity of Required Competencies for Worksite Health Professionals

    Science.gov (United States)

    Becker, Craig; Rager, Robin C.; Wright, Fred Egbert

    2013-01-01

    Background: To improve global health, the workforce capacity of health promotion professionals must be strengthened through the provision of competencies necessary to deliver effective programs. Purpose: This study provides an updated analysis of the validity of the worksite health promotion (WHP) professional competencies developed in 2000 by the…

  18. Experimental update on the exclusive determination of Vcb

    CERN Document Server

    Oyanguren, A

    2003-01-01

    In this talk a review on the exclusive determination of Vcb is presented. Updated values of this quantity obtained from B->Dlnu and B->D*lnu decays are given. New measurements from B-factories are expected to come soon and the main challenges to improve the accuracy on Vcb extracted from these decays are discussed.

  19. IP lookup with low memory requirement and fast update

    DEFF Research Database (Denmark)

    Berger, Michael Stübert

    2003-01-01

    The paper presents an IP address lookup algorithm with low memory requirement and fast updates. The scheme, which is denoted prefix-tree, uses a combination of a trie and a tree search, which is efficient in memory usage because the tree contains exactly one node for each prefix in the routing...... table. The time complexity for update operations is low for the prefix-tree. The lookup operation for the basic binary prefix-tree may require that a high number of nodes be traversed. The paper presents improvements to decrease lookup time, including shortcut tables and multi-bit trees. The prefix...

  20. BIPM Time Activities Update

    Science.gov (United States)

    2009-11-01

    published on the ftp server of the Time, Frequency, and Gravimetry Department of the BIPM [16]. With the aim of introducing GLONASS observations for clock...implemented for the calculation of time links in the BIPM Time, Frequency, and Gravimetry Department in order to improve and refine TAI calculation. For

  1. Nephrogenic systemic fibrosis: epidemiology update

    DEFF Research Database (Denmark)

    Marckmann, P.

    2008-01-01

    Purpose of review The aim of this article is to outline the history of nephrogenic systemic fibrosis, a new and serious disease of patients with renal failure, and to give an update on its aetiology and prevalence. Recent findings Epidemiological and histochemical studies demonstrated that gadoli......Purpose of review The aim of this article is to outline the history of nephrogenic systemic fibrosis, a new and serious disease of patients with renal failure, and to give an update on its aetiology and prevalence. Recent findings Epidemiological and histochemical studies demonstrated...

  2. An updated subgrid orographic parameterization for global atmospheric forecast models

    Science.gov (United States)

    Choi, Hyun-Joo; Hong, Song-You

    2015-12-01

    A subgrid orographic parameterization (SOP) is updated by including the effects of orographic anisotropy and flow-blocking drag (FBD). The impact of the updated SOP on short-range forecasts is investigated using a global atmospheric forecast model applied to a heavy snowfall event over Korea on 4 January 2010. When the SOP is updated, the orographic drag in the lower troposphere noticeably increases owing to the additional FBD over mountainous regions. The enhanced drag directly weakens the excessive wind speed in the low troposphere and indirectly improves the temperature and mass fields over East Asia. In addition, the snowfall overestimation over Korea is improved by the reduced heat fluxes from the surface. The forecast improvements are robust regardless of the horizontal resolution of the model between T126 and T510. The parameterization is statistically evaluated based on the skill of the medium-range forecasts for February 2014. For the medium-range forecasts, the skill improvements of the wind speed and temperature in the low troposphere are observed globally and for East Asia while both positive and negative effects appear indirectly in the middle-upper troposphere. The statistical skill for the precipitation is mostly improved due to the improvements in the synoptic fields. The improvements are also found for seasonal simulation throughout the troposphere and stratosphere during boreal winter.

  3. Finite element modelling and updating of a lively footbridge: The complete process

    Science.gov (United States)

    Živanović, Stana; Pavic, Aleksandar; Reynolds, Paul

    2007-03-01

    The finite element (FE) model updating technology was originally developed in the aerospace and mechanical engineering disciplines to automatically update numerical models of structures to match their experimentally measured counterparts. The process of updating identifies the drawbacks in the FE modelling and the updated FE model could be used to produce more reliable results in further dynamic analysis. In the last decade, the updating technology has been introduced into civil structural engineering. It can serve as an advanced tool for getting reliable modal properties of large structures. The updating process has four key phases: initial FE modelling, modal testing, manual model tuning and automatic updating (conducted using specialist software). However, the published literature does not connect well these phases, although this is crucial when implementing the updating technology. This paper therefore aims to clarify the importance of this linking and to describe the complete model updating process as applicable in civil structural engineering. The complete process consisting the four phases is outlined and brief theory is presented as appropriate. Then, the procedure is implemented on a lively steel box girder footbridge. It was found that even a very detailed initial FE model underestimated the natural frequencies of all seven experimentally identified modes of vibration, with the maximum error being almost 30%. Manual FE model tuning by trial and error found that flexible supports in the longitudinal direction should be introduced at the girder ends to improve correlation between the measured and FE-calculated modes. This significantly reduced the maximum frequency error to only 4%. It was demonstrated that only then could the FE model be automatically updated in a meaningful way. The automatic updating was successfully conducted by updating 22 uncertain structural parameters. Finally, a physical interpretation of all parameter changes is discussed. This

  4. CNMARC的RDA更新*%Updating CNMARC/UNIMARC for RDA

    Institute of Scientific and Technical Information of China (English)

    胡小菁

    2013-01-01

      CNMARC基于UNIMARC。文章分析了截至2012年UNIMARC书目格式针对FRBR的更新,以及UNIMARC永久委员会针对RDA更新的讨论。以UNIMARC2008版对照MARC21的RDA更新,发现在细化子字段以改善描述粒度方面,UNIMARC在某些方面比MARC21做得更早。分析了与MARC21对应需要增加的CNMARC/UNIMARC字段,对可能采用的字段名作了说明。%CNMARC is based on UNIMARC. The article analyses the updates for FRBR in UNIMARC bibliographic format 2012 version (unpublished) and discussion on RDA updates in Permanent UNIMARC Commit ee. A Comparison between UNIMARC 2008 version and MARC 21's RDA updates is made. It's found that UNIMARC's updates in subfields to improve description granularity are earlier than MARC 21. For possible RDA updates in UNIMARC, field tags are selected and explained.

  5. HANFORD TANK CLEANUP UPDATE

    Energy Technology Data Exchange (ETDEWEB)

    BERRIOCHOA MV

    2011-04-07

    Access to Hanford's single-shell radioactive waste storage tank C-107 was significantly improved when workers completed the cut of a 55-inch diameter hole in the top of the tank. The core and its associated cutting equipment were removed from the tank and encased in a plastic sleeve to prevent any potential spread of contamination. The larger tank opening allows use of a new more efficient robotic arm to complete tank retrieval.

  6. Liposuction devices: technology update

    Directory of Open Access Journals (Sweden)

    Shridharani SM

    2014-07-01

    Full Text Available Sachin M Shridharani,1 Justin M Broyles,2 Alan Matarasso11The Department of Plastic Surgery, Manhattan Eye, Ear and Throat Hospital, New York, NY, USA; 2The Department of Plastic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USAAbstract: Since its introduction by Illouz and others over 30 years ago, suction-assisted lipectomy/liposuction/lipoplasty has evolved tremendously and has developed into one of the most popular procedures in aesthetic plastic surgery. Liposuction is an effective procedure employed to treat localized adipose deposits in patients not suffering from generalized obesity. These accumulations of subcutaneous fat often occur in predictable distributions in both men and women. A cannula connected to a suction-generating source allows for small incisions to be strategically placed and large volumes of fat to be removed. This fat removal leads to improved harmonious balance of a patient's physique and improved body contour. Various surgical techniques are available and have evolved as technology has improved. Current technology for liposuction includes suction-assisted lipectomy, ultrasound-assisted, power-assisted, laser-assisted, and radiofrequency-assisted. The choice of technology and technique often depends on patient characteristics and surgeon preference. The objective of this review is to provide a thorough assessment of current technologies available to plastic surgeons performing liposuction.Keywords: laser, lipoplasty, mesotherapy, power-assisted, radiofrequency, ultrasound, water-assisted, coolsculpting

  7. Parkinson disease: an update.

    Science.gov (United States)

    Gazewood, John D; Richards, D Roxanne; Clebak, Karl

    2013-02-15

    Parkinson disease is a progressive neurologic disorder afflicting approximately 1 percent of Americans older than 60 years. The cardinal features of Parkinson disease are bradykinesia, rigidity, tremor, and postural instability. There are a number of neurologic conditions that mimic the disease, making it difficult to diagnose in its early stages. Physicians who rarely diagnose Parkinson disease should refer patients suspected of having it to physicians with more experience in making the diagnosis, and should periodically reevaluate the accuracy of the diagnosis. Treatment is effective in reducing motor impairment and disability, and should be started when a patient begins to experience functional impairment. The combination of carbidopa and levodopa is the most effective treatment, but dopamine agonists and monoamine oxidase-B inhibitors are also effective, and are less likely to cause dyskinesias. For patients taking carbidopa/levodopa who have motor complications, adjunctive therapy with a dopamine agonist, a monoamine oxidase-B inhibitor, or a catechol O-methyltransferase inhibitor will improve motor symptoms and functional status, but with an increase in dyskinesias. Deep brain stimulation is effective in patients who have poorly controlled symptoms despite optimal medical therapy. Occupational, physical, and speech therapy improve patient function. Fatigue, sleep disturbances, dementia, and depression are common in patients with Parkinson disease. Although these conditions are associated with significantly lower quality of life, they may improve with treatment.

  8. CTL Model Update for System Modifications

    CERN Document Server

    Ding, Yulin; Zhang, Yan; Zhang, Y; 10.1613/jair.2420

    2011-01-01

    Model checking is a promising technology, which has been applied for verification of many hardware and software systems. In this paper, we introduce the concept of model update towards the development of an automatic system modification tool that extends model checking functions. We define primitive update operations on the models of Computation Tree Logic (CTL) and formalize the principle of minimal change for CTL model update. These primitive update operations, together with the underlying minimal change principle, serve as the foundation for CTL model update. Essential semantic and computational characterizations are provided for our CTL model update approach. We then describe a formal algorithm that implements this approach. We also illustrate two case studies of CTL model updates for the well-known microwave oven example and the Andrew File System 1, from which we further propose a method to optimize the update results in complex system modifications.

  9. Wind turbine reliability database update.

    Energy Technology Data Exchange (ETDEWEB)

    Peters, Valerie A.; Hill, Roger Ray; Stinebaugh, Jennifer A.; Veers, Paul S.

    2009-03-01

    This report documents the status of the Sandia National Laboratories' Wind Plant Reliability Database. Included in this report are updates on the form and contents of the Database, which stems from a fivestep process of data partnerships, data definition and transfer, data formatting and normalization, analysis, and reporting. Selected observations are also reported.

  10. Upgrade trigger: Biannual performance update

    CERN Document Server

    Aaij, Roel; Couturier, Ben; Esen, Sevda; De Cian, Michel; De Vries, Jacco Andreas; Dziurda, Agnieszka; Fitzpatrick, Conor; Fontana, Marianna; Grillo, Lucia; Hasse, Christoph; Jones, Christopher Rob; Le Gac, Renaud; Matev, Rosen; Neufeld, Niko; Nikodem, Thomas; Polci, Francesco; Del Buono, Luigi; Quagliani, Renato; Schwemmer, Rainer; Seyfert, Paul; Stahl, Sascha; Szumlak, Tomasz; Vesterinen, Mika Anton; Wanczyk, Joanna; Williams, Mark Richard James; Yin, Hang; Zacharjasz, Emilia Anna

    2017-01-01

    This document presents the performance of the LHCb Upgrade trigger reconstruction sequence, incorporating changes to the underlying reconstruction algorithms and detector description since the Trigger and Online Upgrade TDR. An updated extrapolation is presented using the most recent example of an Event Filter Farm node.

  11. Mozambique Economic Update, December 2016

    OpenAIRE

    2016-01-01

    This Mozambique economic update brief for 2016 includes a section on recent economic developments and a discussion of Mozambique’s economic outlook, followed by focus section(s) analyzing issues of particular importance.This has been a testing year for Mozambique. An ongoing downturn, brought about by low commodity prices, drought and conflict, was compounded by the fallout from the discov...

  12. Bangladesh Development Update, October 2016

    OpenAIRE

    2016-01-01

    This update introduces Bangladesh's new poverty numbers at $1.90 per capita per day in 2011 purchasing power parity (PPP) prices, followed by an account of recent economic development, the outlook, risks, and policy responses. The revised poverty rates are significantly lower, but follow the same downward historical trend seen when using the 2005 international extreme poverty line. Banglad...

  13. Anterior cruciate ligament - updating article

    Directory of Open Access Journals (Sweden)

    Marcus Vinicius Malheiros Luzo

    2016-08-01

    Full Text Available ABSTRACT This updating article on the anterior cruciate ligament (ACL has the aim of addressing some of the most interesting current topics in this field. Within this stratified approach, it contains the following sections: ACL remnant; anterolateral ligament and combined intra and extra-articular reconstruction; fixation devices; and ACL femoral tunnel creation techniques.

  14. Evidence-based guideline update

    DEFF Research Database (Denmark)

    Tfelt-Hansen, Peer Carsten

    2013-01-01

    Peer Carsten Tfelt-Hansen, Glostrup, Denmark: According to the recent American Academy of Neurology (AAN) guideline update, a drug can be recommended as possibly effective for migraine prevention if it had demonstrated efficacy in one Class II study.(1) Eight drugs are recommended as possibly...

  15. Update of CERN exchange network

    CERN Multimedia

    2003-01-01

    An update of the CERN exchange network will be done next April. Disturbances or even interruptions of telephony services may occur from 4th to 24th April during evenings from 18:30 to 00:00 but will not exceed more than 4 consecutive hours (see tentative planning below). In addition, the voice messaging system will be shut down on March, 26th April from 18:00 to 00:00. Calls supposed to be routed to the voice messaging system will not be possible during the shutdown. CERN divisions are invited to avoid any change requests (set-ups, move or removals) of telephones and fax machines from 4th to 25th April. Everything will be done to minimize potential inconveniences which may occur during this update. There will be no loss of telephone functionalities. CERN GSM portable phones won't be affected by this change. Should you need more details, please send us your questions by email to Standard.Telephone@cern.ch. Date Change type Affected areas April 8 Update of switch in LHC 7 LHC 7 Point April 9 Update of...

  16. Update of CERN exchange network

    CERN Multimedia

    2003-01-01

    An update of the CERN exchange network will be done next April. Disturbances or even interruptions of telephony services may occur from 4th to 24th April during evenings from 18:30 to 00:00 but will not exceed more than 4 consecutive hours (see tentative planning below). In addition, the voice messaging system will be shut down on March, 26th April from 18:00 to 00:00. Calls supposed to be routed to the voice messaging system will not be possible during the shutdown. CERN divisions are invited to avoid any change requests (set-ups, move or removals) of telephones and fax machines from 4th to 25th April. Everything will be done to minimize potential inconveniences which may occur during this update. There will be no loss of telephone functionalities. CERN GSM portable phones won't be affected by this change. Should you need more details, please send us your questions by email to Standard.Telephone@cern.ch. DateChange typeAffected areas March 26Update of the voice messaging systemAll CERN sites April 4Updat...

  17. AMDIS and CHART update. 1

    Energy Technology Data Exchange (ETDEWEB)

    Murakami, I.; Kato, T. [National Inst. for Fusion Science, Toki, Gifu (Japan); Igarashi, A. [Miyazaki Univ., Miyazaki (JP)] [and others

    2002-10-01

    A working group for updating atomic and molecular collision data in the NIFS database AMDIS (electron scattering) and CHART (ion scattering) has been organized. This group has searched and reviewed literatures for collecting relevant atomic data with are to be included into the database. This is a summary report of the activities of this working group. (author)

  18. A Mathematics Software Database Update.

    Science.gov (United States)

    Cunningham, R. S.; Smith, David A.

    1987-01-01

    Contains an update of an earlier listing of software for mathematics instruction at the college level. Topics are: advanced mathematics, algebra, calculus, differential equations, discrete mathematics, equation solving, general mathematics, geometry, linear and matrix algebra, logic, statistics and probability, and trigonometry. (PK)

  19. Legal Update of Gifted Education

    Science.gov (United States)

    Zirkel, Perry A.

    2016-01-01

    This update of the legislation/regulations and case law specific to pre-K-12 gifted students since a cluster of publications in 2004-2005 primarily focuses on the "gifted alone" category, with only secondary attention to twice-exceptional and other students in the "gifted plus" category. For the gifted-alone category, the…

  20. Eczema and ceramides: an update

    DEFF Research Database (Denmark)

    Jungersted, Jakob Mutanu; Agner, Tove

    2013-01-01

    types of treatment. We also consider the genetic influence on stratum corneum lipids. The review is an update on research indexed in PubMed following the discovery of the filaggrin mutations in atopic dermatitis in 2006, but when newer publications cannot stand alone, we include publications from before...

  1. NACRE Update and Extension Project

    Science.gov (United States)

    Aikawa, Masayuki; Arai, Koji; Arnould, Marcel; Takahashi, Kohji; Utsunomiya, Hiroaki

    2006-04-01

    NACRE, the `nuclear astrophysics compilation of reaction rates', has been widely utilized in stellar evolution and nucleosynthesis studies since its publication in 1999. We describe here the current status of a Konan-Université Libre de Bruxelles (ULB) joint project that aims at its update and extension.

  2. Anterior cruciate ligament - updating article.

    Science.gov (United States)

    Luzo, Marcus Vinicius Malheiros; Franciozi, Carlos Eduardo da Silveira; Rezende, Fernando Cury; Gracitelli, Guilherme Conforto; Debieux, Pedro; Cohen, Moisés

    2016-01-01

    This updating article on the anterior cruciate ligament (ACL) has the aim of addressing some of the most interesting current topics in this field. Within this stratified approach, it contains the following sections: ACL remnant; anterolateral ligament and combined intra and extra-articular reconstruction; fixation devices; and ACL femoral tunnel creation techniques.

  3. Model validation: Correlation for updating

    Indian Academy of Sciences (India)

    D J Ewins

    2000-06-01

    In this paper, a review is presented of the various methods which are available for the purpose of performing a systematic comparison and correlation between two sets of vibration data. In the present case, the application of interest is in conducting this correlation process as a prelude to model correlation or updating activity.

  4. Belief update as social choice

    NARCIS (Netherlands)

    van Benthem, J.; Girard, P.; Roy, O.; Marion, M.

    2011-01-01

    Dynamic epistemic-doxastic logics describe the new knowledge or new beliefs indexBelief of agents after some informational event has happened. Technically, this requires an update rule that turns a doxastic-epistemic modelM(recording the current information state of the agents) and a dynamic ‘event

  5. [Dermatomyositis-update].

    Science.gov (United States)

    Volc-Platzer, B

    2015-08-01

    Dermatomyositis is a rare idiopathic inflammatory myopathy that affects adults and children, mostly female. Hallmarks of the disease are myositis with necrosis, regeneration and perifascicular atrophy accompanied by a typical skin rash with heliotrope erythema, Gottron's sign, Gottron's papules and nail fold changes with splinter hemorrhage. Typical skin symptoms may appear 6 months up to 2 years before muscle involvement (amyopathic dermatomyositis). New myositis-specific antibodies may allow clinicoserologic correlations within a heterogeneous clinical spectrum. Autoantibody profiles, subtype of myositis, overlap with other collagen vascular disorders and/or malignancy (paraneoplastic dermatomyositis) as well as age of the patients all have a considerable impact on course and prognosis. Infections, drugs and tumors may trigger activation of T and B cells, plasmacytoid dendritic cells, overproduction of type I interferons and complement-mediated endothelial cell damage resulting in vasculopathy. UV radiation may also trigger dermatomyositis. Oral corticosteroids (1.5-2.0 mg/kg body weight/day) are the mainstay of treatment until improvement of muscle symptoms and/or normalization of muscle enzymes with subsequent slow tapering. Corticosteroids may be given as monotherapy or combined with steroid-sparing immunosuppressive agents' i.e. azathioprine, methotrexate, mycophenolate mofetil or high-dose intravenous immunoglobulins. Prognosis has improved considerably since use of high-dose corticosteroids, from 50 to 90% response rate. New therapies with biologicals (anti-CD20-, anti-TNFalpha-, anti-interferon antibodies) and Janus kinase inhibitors are currently being evaluated.

  6. Anthrax: an update

    Science.gov (United States)

    Kamal, SM; Rashid, AKM M; Bakar, MA; Ahad, MA

    2011-01-01

    Anthrax is a zoonotic disease caused by Bacillus anthracis. It is potentially fatal and highly contagious disease. Herbivores are the natural host. Human acquire the disease incidentally by contact with infected animal or animal products. In the 18th century an epidemic destroyed approximately half of the sheep in Europe. In 1900 human inhalational anthrax occured sporadically in the United States. In 1979 an outbreak of human anthrax occured in Sverdlovsk of Soviet Union. Anthrax continued to represent a world wide presence. The incidence of the disease has decreased in developed countries as a result of vaccination and improved industrial hygiene. Human anthrax clinically presents in three forms, i.e. cutaneous, gastrointestinal and inhalational. About 95% of human anthrax is cutaneous and 5% is inhalational. Gastrointestinal anthrax is very rare (less than 1%). Inhalational form is used as a biological warefare agent. Penicillin, ciprofloxacin (and other quinolones), doxicyclin, ampicillin, imipenem, clindamycin, clarithromycin, vancomycin, chloramphenicol, rifampicin are effective antimicrobials. Antimicrobial therapy for 60 days is recommended. Human anthrax vaccine is available. Administration of anti-protective antigen (PA) antibody in combination with ciprofloxacin produced 90%-100% survival. The combination of CPG-adjuvanted anthrax vaccine adsorbed (AVA) plus dalbavancin significantly improved survival. PMID:23569822

  7. Anthrax:an update

    Institute of Scientific and Technical Information of China (English)

    Kamal SM; Rashid AKM M; Bakar MA; Ahad MA

    2011-01-01

    Anthrax is a zoonotic disease caused by Bacillus anthracis. It is potentially fatal and highly contagious disease. Herbivores are the natural host. Human acquire the disease incidentally by contact with infected animal or animal products. In the 18th century an epidemic destroyed approximately half of the sheep in Europe. In 1900 human inhalational anthrax occured sporadically in the United States. In 1979 an outbreak of human anthrax occured in Sverdlovsk of Soviet Union. Anthrax continued to represent a world wide presence. The incidence of the disease has decreased in developed countries as a result of vaccination and improved industrial hygiene. Human anthrax clinically presents in three forms, i.e. cutaneous, gastrointestinal and inhalational. About 95% of human anthrax is cutaneous and 5% is inhalational. Gastrointestinal anthrax is very rare (less than 1%). Inhalational form is used as a biological warefare agent. Penicillin, ciprofloxacin (and other quinolones), doxicyclin, ampicillin, imipenem, clindamycin, clarithromycin, vancomycin, chloramphenicol, rifampicin are effective antimicrobials. Antimicrobial therapy for 60 days is recommended. Human anthrax vaccine is available. Administration of anti-protective antigen (PA) antibody in combination with ciprofloxacin produced 90%-100% survival. The combination of CPG-adjuvanted anthrax vaccine adsorbed (AVA) plus dalbavancin significantly improved survival.

  8. 75 FR 70124 - Product List Update

    Science.gov (United States)

    2010-11-17

    ... 30 CFR Part 3020 Product List Update AGENCY: Postal Regulatory Commission. ACTION: Final rule... Commission order. The referenced policy assumes periodic updates. The updates are identified in the body of this document. The product lists, which are re-published in their entirety, include these...

  9. 76 FR 1357 - Product List Update

    Science.gov (United States)

    2011-01-10

    ... 30 CFR Part 3020 Product List Update AGENCY: Postal Regulatory Commission. ACTION: Final rule... Commission order. The referenced policy assumes periodic updates. The updates are identified in the body of this document. The product lists, which are re-published in their entirety, include these...

  10. 77 FR 41258 - FOIA Fee Schedule Update

    Science.gov (United States)

    2012-07-13

    ... SAFETY BOARD 10 CFR Part 1703 FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board... publishing its Freedom of Information Act (FOIA) Fee Schedule Update pursuant to the Board's regulations..., the Board's General Manager will update the FOIA Fee Schedule once every 12 months. The previous...

  11. 75 FR 81037 - Waste Confidence Decision Update

    Science.gov (United States)

    2010-12-23

    ... COMMISSION 10 CFR Part 51 Waste Confidence Decision Update AGENCY: Nuclear Regulatory Commission. ACTION: Update and final revision of Waste Confidence Decision. SUMMARY: The U.S. Nuclear Regulatory Commission... update to the Decision were products of rulemaking proceedings designed to assess the degree of...

  12. 76 FR 43819 - FOIA Fee Schedule Update

    Science.gov (United States)

    2011-07-22

    ... SAFETY BOARD 10 CFR Part 1703 FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board... publishing its Freedom of Information Act (FOIA) Fee Schedule Update pursuant to the Board's regulations... General Manager will update the FOIA Fee Schedule once every 12 months. The previous Fee Schedule...

  13. 76 FR 9648 - Product List Update

    Science.gov (United States)

    2011-02-22

    ... 39 CFR Part 3020 Product List Update AGENCY: Postal Regulatory Commission. ACTION: Final rule... Commission order. The referenced policy assumes periodic updates. The updates are identified in the body of this document. The product lists, which are re-published in their entirety, include these...

  14. 77 FR 75377 - Product List Update

    Science.gov (United States)

    2012-12-20

    ... 39 CFR Part 3020 Product List Update AGENCY: Postal Regulatory Commission. ACTION: Final rule... Commission order. The referenced policy assumes periodic updates. The updates are identified in the body of this document. The product lists, which are re-published in their entirety, include these...

  15. Updated Colombian Seismic Hazard Map

    Science.gov (United States)

    Eraso, J.; Arcila, M.; Romero, J.; Dimate, C.; Bermúdez, M. L.; Alvarado, C.

    2013-05-01

    possible to determinate environments and scenarios where the seismic hazard is a function of distance and magnitude and also the principal seismic sources that contribute to the seismic hazard at each site (dissagregation). This project was conducted by the Servicio Geológico Colombiano (Colombian Geological Survey) and the Universidad Nacional de Colombia (National University of Colombia), with the collaboration of national and foreign experts and the National System of Prevention and Attention of Disaster (SNPAD). It is important to stand out that this new seismic hazard map was used in the updated national building code (NSR-10). A new process is ongoing in order to improve and present the Seismic Hazard Map in terms of intensity. This require new knowledge in site effects, in both local and regional scales, checking the existing and develop new acceleration to intensity relationships, in order to obtain results more understandable and useful for a wider range of users, not only in the engineering field, but also all the risk assessment and management institutions, research and general community.

  16. Contraception - Update and Trends

    Directory of Open Access Journals (Sweden)

    Rabe T

    2010-01-01

    Full Text Available Fertility control in the future will focus on the improvement of existing methods (efficacy, side effects, easy use, duration of action, manufacturing process, costs, on new approaches (mode of action bringing additional health benefits, and on new targets for nonhormonal contraception. Counselling of women in view to contraceptive choices based on the individual risk (e. g. cardiovascular disease, thrombophilia, family risk of breast cancer, sexually transmitted diseases will gain more and more importance. Only a few companies can afford research in contraception such as Bayer-Schering-Pharma, and MSD. Female contraception: Ovulation inhibition: preselection of patients to minimize the individual risk. New oral contraceptive (OC regimen, OC with new progestins, OC with estradiol or estradiol esters, new ovulation inhibitors with new progestins and new regimen including long cycles and continuous delivery of steroidal contraceptives, new contraceptive patches, vaginal rings andsprayon contraceptives. Recently identified genes involved in the ovulation process as new targets for ovulation inhibitors. Fertilisation inhibition: new intrauterine systems have been developed: a smaller Mirena intrauterine system releasing levonorgestrel (LNG and a new frameless progestinreleasing intrauterine systems (IUS. Various new contraceptive barriers have been introduced. Research is ongoing on substances acting both as spermicide and as microbicides as a dualprotection method reducing both the risk of unwanted pregnancy and the risk of sexually transmitted diseases. New implantable systems and improved injectables (with improved pharmacokinetic profile, decreased side effects and a safer delivery system have been made available recently. Various new approaches in female sterilisation include non invasive method of tubal occlusion Immunocontraception for the female will not be available in the near future. Implantation inhibition: selective progesterone

  17. Update on cutaneous calciphylaxis

    Directory of Open Access Journals (Sweden)

    Uwe Wollina

    2013-01-01

    Full Text Available Calciphylaxis is a devastating disorder with a mortality rate of 80% due to sepsis and organ failure. Hallmarks of this rare disease are arteriolar media calcification, thrombotic cutaneous ischemia, and necrotic ulcerations. Different mechanisms of vascular calcification can lead to calciphylaxis. Early diagnosis by deep cutaneous ulcer biopsy is most important for prognosis. Here, dermatologists play a significant role although treatment usually needs an interdisciplinary approach. Surgical procedures had been the cornerstone of treatment in the past including parathyroidectomy, but recently new medical treatments emerged aiming to normalize disturbances of minerals to reduce the serum concentration of sodium phosphate and to prevent precipitation and calcification. Multimodal therapy is warranted but only aggressive surgical debridement of cutaneous ulcers has shown significant outcome improvement.

  18. Female athlete triad update.

    Science.gov (United States)

    Beals, Katherine A; Meyer, Nanna L

    2007-01-01

    The passage of Title IX legislation in 1972 provided enormous opportunities for women to reap the benefits of sports participation. For most female athletes, sports participation is a positive experience, providing improved physical fitness, enhanced self-esteem, and better physical and mental health. Nonetheless, for a few female athletes, the desire for athletic success combined with the pressure to achieve a prescribed body weight may lead to the development of a triad of medical disorders including disordered eating, menstrual dysfunction, and low bone mineral density (BMD)--known collectively as the female athlete triad. Alone or in combination, the disorders of the triad can have a negative impact on health and impair athletic performance.

  19. [Update on infective endocarditis].

    Science.gov (United States)

    Parize, P; Mainardi, J-L

    2011-10-01

    Infective endocarditis has continuously evolved since its first clinical description by William Osler in the late 19th century. The epidemiological and microbiological profile of the disease has changed as the result of the progress of the medical care and demographic mutation in industrialized countries. Furthermore, advances in anti-infective therapy and in cardiovascular surgery have contributed to an improvement in the management and the prognosis of this severe infectious disease. During the past decade, the recommendations on antibiotic prophylaxis against infective endocarditis have changed dramatically. Guidelines on management of infective endocarditis and state-of-the-art articles have been published recently and this work aims to outline current recommendations about this evolving disease.

  20. Tenofovir Nephrotoxicity: 2011 Update

    Directory of Open Access Journals (Sweden)

    Beatriz Fernandez-Fernandez

    2011-01-01

    Full Text Available Tenofovir is an acyclic nucleotide analogue reverse-transcriptase inhibitor structurally similar to the nephrotoxic drugs adefovir and cidofovir. Tenofovir is widely used to treat HIV infection and approved for treatment of hepatitis B virus. Despite initial cell culture and clinical trials results supporting the renal safety of tenofovir, its clinical use is associated with a low, albeit significant, risk of kidney injury. Proximal tubular cell secretion of tenofovir explains the accumulation of the drug in these mitochondria-rich cells. Tenofovir nephrotoxicity is characterized by proximal tubular cell dysfunction that may be associated with acute kidney injury or chronic kidney disease. Withdrawal of the drug leads to improvement of analytical parameters that may be partial. Understanding the risk factors for nephrotoxicity and regular monitoring of proximal tubular dysfunction and serum creatinine in high-risk patients is required to minimize nephrotoxicity. Newer, structurally similar molecular derivatives that do not accumulate in proximal tubules are under study.

  1. Androgenetic alopecia: An update

    Directory of Open Access Journals (Sweden)

    Feroze Kaliyadan

    2013-01-01

    Full Text Available Androgenetic alopecia (AGA is one of the commonest reasons for dermatological consultation. Over the last few years our understanding of the pathophysiology of AGA has improved and this has paved way for better diagnostic and therapeutic options. Recent research has dwelled on the role of stem cells in the pathophysiology of AGA and has also identified newer genetic basis for the condition. Dermoscopy/trichoscopy has emerged as a useful diagnostic tool for AGA. While the major treatment options continue to be topical minoxidil, systemic Finasteride and hair transplantations, newer modalities are under investigation. Specific diagnostic and treatment recommendations have also been developed on evidence based principles. This article reviews the recent concepts in relation to AGA. With regards to the pathophysiology we have tried to stress on recent knowledge of the molecular and genetic basis of AGA. We have emphasized on an evidence based approach for treatment and diagnosis.

  2. Contraception - Update and Trends

    Directory of Open Access Journals (Sweden)

    Rabe T

    2007-01-01

    Full Text Available In the future, fertility control will focus on the improvement of existing methods (efficacy, side effects, easy use, duration of action, manufacturing process, costs, on new approaches (mode of action and on new targets for contraception. Counselling of women in view of contraceptive choices based on individual risks (e. g. cardiovascular disease, thrombophilia, family risk of breast cancer, sexually transmitted diseases will gain more and more importance. Only a few companies can afford research in contraception such as Bayer-Schering-Pharma, Wyeth-Ayerst, Ortho-McNeil and Organon. Female contraception: Ovulation inhibition: In the future, a focus will be placed on the preselection of patients to minimize their individual risk, new oral contraceptive (OC regimen, OC with new progestins, OC with estradiol or estradiolesters, new ovulation inhibitors with new progestins and new regimens including long cycles and continuous steroidal contraceptives, new contraceptive patches, vaginal rings, spray-on contraceptives, recently identified genes involved in the ovulation process as new targets for ovulation inhibitors. Fertilisation inhibition: New intrauterine systems will comprise: a smaller Mirena intrauterine system releasing levonorgestrel (LNG and new frameless progestin-releasing intrauterine systems (IUS. Various new contraceptive barriers have been introduced. Research is ongoing on substances acting both as spermicides and as microbicides, reducing the risk of sexually transmitted diseases. New implantables and injectables will feature an improved pharmacokinetic profile, decreased side effects and a safer delivery system. Additionally, there are various new approaches in female sterilisation. Immunocontraception for the female will not be available in the near future. Implantation inhibition: Selective progesterone receptor modulators (SPRMs are tested for postcoital contraception. New targets are analysed for immunocontraceptives. Male

  3. An updated comprehensive techno-economic analysis of algae biodiesel.

    Science.gov (United States)

    Nagarajan, Sanjay; Chou, Siaw Kiang; Cao, Shenyan; Wu, Chen; Zhou, Zhi

    2013-10-01

    Algae biodiesel is a promising but expensive alternative fuel to petro-diesel. To overcome cost barriers, detailed cost analyses are needed. A decade-old cost analysis by the U.S. National Renewable Energy Laboratory indicated that the costs of algae biodiesel were in the range of $0.53-0.85/L (2012 USD values). However, the cost of land and transesterification were just roughly estimated. In this study, an updated comprehensive techno-economic analysis was conducted with optimized processes and improved cost estimations. Latest process improvement, quotes from vendors, government databases, and other relevant data sources were used to calculate the updated algal biodiesel costs, and the final costs of biodiesel are in the range of $0.42-0.97/L. Additional improvements on cost-effective biodiesel production around the globe to cultivate algae was also recommended. Overall, the calculated costs seem promising, suggesting that a single step biodiesel production process is close to commercial reality.

  4. A New Communication Theory on Complex Information and a Groundbreaking New Declarative Method to Update Object Databases

    OpenAIRE

    Virkkunen, Heikki

    2016-01-01

    In this article I introduce a new communication theory for complex information represented as a direct graph of nodes. In addition, I introduce an application for the theory, a new radical method, embed, that can be used to update object databases declaratively. The embed method revolutionizes updating of object databases. One embed method call can replace dozens of lines of complicated updating code in a traditional client program of an object database, which is a huge improvement. As a decl...

  5. VLTI status update: a decade of operations and beyond

    Science.gov (United States)

    Mérand, Antoine; Abuter, Roberto; Aller-Carpentier, Emmanuel; Andolfato, Luigi; Alonso, Jaime; Berger, Jean-Philippe; Blanchard, Guillaume; Boffin, Henri; Bourget, Pierre; Bristow, Paul; Cid, Claudia; de Wit, Willem-Jan; del Valle, Diego; Delplancke-Ströbele, Françoise; Derie, Frédéric; Faundez, Lorena; Ertel, Steve; Grellmann, Rebekka; Gitton, Philippe; Glindemann, Andreas; Guajardo, Patricia; Guieu, Sylvain; Guisard, Stéphane; Guniat, Serge; Haguenauer, Pierre; Herrera, Cristian; Hummel, Christian; La Fuente, Carlos; Lopez, Marcelo; Mardones, Pedro; Morel, Sébastien; Müller, André; Percheron, Isabelle; Duc, Than Phan; Pino, Andres; Poupar, Sébastien; Pozna, Eszter; Ramirez, Andres; Rengaswamy, Srihdaran; Rivas, Lionel; Rivinius, Thomas; Segovia, Alex; Schmid, Christian; Schöller, Markus; Schuhler, Nicolas; Woillez, Julien; Wittkowski, Markus

    2014-07-01

    We present the latest update of the European Southern Observatory's Very Large Telescope interferometer (VLTI). The operations of VLTI have greatly improved in the past years: reduction of the execution time; better offering of telescopes configurations; improvements on AMBER limiting magnitudes; study of polarization effects and control for single mode fibres; fringe tracking real time data, etc. We present some of these improvements and also quantify the operational improvements using a performance metric. We take the opportunity of the first decade of operations to reflect on the VLTI community which is analyzed quantitatively and qualitatively. Finally, we present briefly the preparatory work for the arrival of the second generation instruments GRAVITY and MATISSE.

  6. VLTI status update: a decade of operations and beyond

    CERN Document Server

    Merand, Antoine; Aller-Carpentier, Emmanuel; Andolfato, Luigi; Alonso, Jaime; Berger, Jean-Philippe; Blanchard, Guillaume; Boffin, Henri; Bourget, Pierre; Bristow, Paul; Cid, Claudia; de Wit, Willem-Jan; del Valle, Diego; Delplancke-Stroebele, Franccoise; Derie, Frederic; Faundez, Lorena; Ertel, Steve; Grellmann, Rebekka; Gitton, Philippe; Glindemann, Andreas; Guajardo, Patricia; Guieu, Sylvain; Guisard, Stephane; Guniat, Serge; Haguenauer, Pierre; Herrera, Christian; Hummel, Christian; La Fuente, Carlos; Lopez, Marcelo; Mardones, Pedro; Morel, Sebastien; Mueller, Andre; Percheron, Isabelle; Duc, Than Phan; Pino, Andres; Poupar, Sebastien; Pozna, Eszter; Ramirez, Andres; Rengaswamy, Sridharan; Rivas, Lionel; Rivinius, Thomas; Segovia, Alex; Schmid, Christian; Schoeller, Markus; Schuhler, Nicolas; Woillez, Julien; Wittkowski, Markus

    2014-01-01

    We present the latest update of the European Southern Observatory's Very Large Telescope interferometer (VLTI). The operations of VLTI have greatly improved in the past years: reduction of the execution time; better offering of telescopes configurations; improvements on AMBER limiting magnitudes; study of polarization effects and control for single mode fibres; fringe tracking real time data, etc. We present some of these improvements and also quantify the operational improvements using a performance metric. We take the opportunity of the first decade of operations to reflect on the VLTI community which is analyzed quantitatively and qualitatively. Finally, we present briefly the preparatory work for the arrival of the second generation instruments GRAVITY and MATISSE.

  7. [Bariatric surgery: an update].

    Science.gov (United States)

    Moreno Esteban, B; Zugasti Murillo, A

    2004-01-01

    The indication of bariatric surgery as therapeutic procedure for morbid obese patients requires the application of selection criteria which deal with the degree of obesity, associated complications and previous failure of conventional therapy. Alcohol or drug addiction and concomitant serious disease are contraindications for bariatric surgery. Before operation, a full assessment is needed to identify possible eating behaviour disturbances and associated comorbidity such as cardiovascular disease, sleep apnoea, metabolic and psychiatric alterations which might induce intra and postoperative complications. Surgical techniques can be classified as restrictive, malabsortive and mixed procedures. Gastroplasty and adjustable gastric banding are restrictive techniques, which are indicated in obese patients with body mass index less than 45 kg/m2. Mixed techniques are the most used procedures. They include gastric by-pass which causes a reduction of 60-70% of weight excess, biliopancreatic diversion and duodenal switch which can eliminate a 75% of body weight excess. Following bariatric surgery a dramatic improvement in associated comorbidity can be demonstrated, specially in what refers to diabetes, hypertension, dislipidaemia and apnoea. Postoperative mortality is around 1-2%. Peritonitis and venous thromboembolism are the most serious complications. Postoperative follow-up should be lifelong and requires a progressive nutrition planning and vitamin supplementation.

  8. Update in endocrine autoimmunity.

    Science.gov (United States)

    Anderson, Mark S

    2008-10-01

    The endocrine system is a common target in pathogenic autoimmune responses, and there has been recent progress in our understanding, diagnosis, and treatment of autoimmune endocrine diseases. Rapid progress has recently been made in our understanding of the genetic factors involved in endocrine autoimmune diseases. Studies on monogenic autoimmune diseases that include endocrine phenotypes like autoimmune polyglandular syndrome type 1 and immune dysregulation, polyendocrinopathy, enteropathy, X-linked have helped reveal the role of key regulators in the maintenance of immune tolerance. Highly powered genetic studies have found and confirmed many new genes outside of the established role of the human leukocyte antigen locus with these diseases, and indicate an essential role of immune response pathways in these diseases. Progress has also been made in identifying new autoantigens and the development of new animal models for the study of endocrine autoimmunity. Finally, although hormone replacement therapy is still likely to be a mainstay of treatment in these disorders, there are new agents being tested for potentially treating and reversing the underlying autoimmune process. Although autoimmune endocrine disorders are complex in etiology, these recent advances should help contribute to improved outcomes for patients with, or at risk for, these disorders.

  9. Updates on Pancreatic Cancer

    Directory of Open Access Journals (Sweden)

    Ojas Vyas

    2014-05-01

    Full Text Available Pancreatic adenocarcinoma remains a therapeutic challenge. The American Cancer Society estimates that in 2014 about 46,420 people will be diagnosed with pancreatic cancer and about 39,590 people will die of pancreatic cancer in the United States [1]. The incidence of pancreatic carcinoma has markedly increased over the past several decades and it now ranks as the fourth leading cause of cancer-related death in the United States. Despite the high mortality rate associated with pancreatic cancer, its etiology is poorly understood. Although progress in the development of new cytotoxic and biological drugs for the treatment of pancreatic cancer continues, the outcome remains grim. Many organizations and associations have taken an effort to improve knowledge, understanding and outcome of patients with pancreatic cancer. Pancreas Club, since its founding in 1966, is aimed to promote the interchange of ideas between physicians and scientists focused on pancreas throughout the world in an informal “club” atmosphere. We attended the 48th Annual Meeting of Pancreas Club in Chicago and reviewed many interesting posters and oral presentations. Here we discuss a few selected abstracts.

  10. Updates in immunoassays: virology.

    Science.gov (United States)

    Josko, Deborah

    2012-01-01

    Virus identification is a challenge to the clinical microbiologist since growing viruses in traditional cell culture is labor intensive, time consuming, and subject to contamination. The advent of rapid and automated immunoassays has eliminated this problem by generating positive results in minutes to hours. For example, testing for infectious mononucleosis can yield a positive result in 3-8 minutes as seen with the Beckman Coulter, Inc. ICON Mono test or in 5-15 minutes with the MONO Mononucleosis Rapid Test Device marketed by ACON Laboratories, Inc. Fully automated immunoassay analyzers provide fast, accurate, sensitive results that aid in a prompt and accurate diagnosis for the patient. Turnaround times are shortened, allowing for timely medical intervention and treatment. The priority in any hospital or medical facility is to treat the patient as quickly and appropriately as possible. By using immunoassays, clinical laboratory professionals are able to report out correct results in a timely manner, ensuring overall positive patient outcomes and improved quality of healthcare.

  11. PACE Status Update

    Energy Technology Data Exchange (ETDEWEB)

    M., Zimring,; Hoffman, I.; Fuller, M.

    2010-08-11

    The Federal Housing Finance Agency (FHFA) regulates Fannie Mae, Freddie Mac, and the 12 Federal Home Loan Banks (the government-sponsored enterprises - GSEs). On July 6, 2010, FHFA and the Office of the Comptroller of the Currency (OCC) concluded that Property Assessed Clean Energy (PACE) programs 'present significant safety and soundness concerns' to the housing finance industry. This statement came after a year of discussions with state and federal agencies in which PACE, a novel mechanism for financing energy efficiency and renewable energy improvements, has gone from receiving support from the White House, canonization as one of Scientific American's 'World Changing Ideas' and legislative adoption in 24 states to questionable relevance, at least in the residential sector. Whether PACE resumes its expansion as an innovative tool for financing energy efficiency and clean generation depends on outcomes in each of the three branches of government - discussions on a PACE pilot phase among federal agencies, litigation in federal court, and legislation in Congress - all highly uncertain. This policy brief addresses the practical impacts of these possible outcomes on existing and emerging PACE programs across the United States and potential paths forward.

  12. [Dentin adhesives. An update].

    Science.gov (United States)

    Grandini, R; Novelli, C; Pierleoni, P

    1991-11-01

    Even if mechanical bonding to enamel utilizing the acid-etch technique has been very successful, adhesion to dentin is still a challenge to researchers and clinicians. Dentin is a vital tissue and differs in composition from enamel: acid-etching does not enhance the bond strength of composite resins to dentin and may elicit a severe pulpal response. For an effective bond to occur, a dentin bonding system has to be used. The first generation of methacrylate-based dentin adhesives was capable of chemical bonding to the inorganic phase of dentin. The chemical basis for this resin-dentin adhesive was the interaction between a phosphate group attached to the methacrylate and the calcium ions on the dentin surface. This system yielded rather low bond strengths which were clinically unsatisfying. The second generation of dentin adhesives became available to the profession recently. Each of these new bonding systems use similar chemical composition for the same purpose of bonding with physicochemical interaction to the hard tooth tissues. All these systems contain a mild acid dentin conditioner to remove the smear layer and an aqueous resin containing primer to improve monomer penetration into the hydrophilic dentin surface. The second generation dentin bonding systems are extremely sensitive to variations upon the completeness of instructions and how accurately these are followed by dental practitioners.

  13. Gonorrhoea diagnostics: An update

    Directory of Open Access Journals (Sweden)

    R Verma

    2016-01-01

    Full Text Available Diagnosis of gonorrhoea is an ongoing challenge. The organism is fastidious requiring meticulous collection and transport for successful cultivation. Asymptomatic infections are common which go undetected by conventional methods thereby leading to continued transmission and the risk of complications. The nucleic acid amplification tests, now increasingly used in developed countries, offer improved sensitivity compared to bacterial culture. However, these continue to suffer sequence related problems leading to false positive and false negative results. Further, these cannot be used for generation of data on antibiotic susceptibility because genetic markers of antibiotic resistance to recommended therapies have not been fully characterised. They are unaffordable in a setting like ours where reliance is placed on syndromic approach for sexually transmitted infection (STI management. The use of syndromic approach has resulted in a considerable decline in the number of Neisseria gonorrhoeae isolates that have been cultured for diagnostic purposes. Many laboratories formerly doing so are no longer performing culture for gonococci, and the basic skills have been lost. There is a need to not only revive this skill but also adopt newer technologies that can aid in accurate diagnosis in a cost-effective manner. There is room for innovation that can facilitate the development of a point-of-care test for this bacterial STI.

  14. [Blood culture update].

    Science.gov (United States)

    Muller-Serieys, C; Bergogne-Bérézin, E

    2002-01-12

    Blood culture is one of the most important bacteriological examinations with important clinical and therapeutic consequences. Blood cultures should be ordered in all patients with signs suggesting septicemia, endocarditis or severe infection (pneumococcal pneumonia, bacterial meningitis with bloodstream dissemination). Blood culture methods have evolved considerably over the last twenty years. After using manual methods for many years, read by non-standardized visual methods, the development of media with defined compositions and supplemented to allow growth of bacteria difficult to culture has been associated with the development of automatic blood culture devices. These devices have undergone rapid improvement. Semi-automatic devices (Bactec NR-660) were rapidly followed by completely automatic techniques, including four devices currently available: since 1989 Bio-Argos (Rio-Rad) and Bact/Alert (Organon-Teknika) and in 1993, Bactec 9240 (Becton-Dickinson) and Vital (BioMérieux). All these devices allow automatic detection of CO2 produced during bacterial growth. Automatic reading systems provide continuous output avoiding the need for invasive methods and thus the risk of contamination in addition to saving time. Potential application to achieve quantitative blood cultures for intensive care units is in the development stage. The reliability of these devices is well recognized and their contribution to severe bacterial infection is undeniable. There are certain limitations however related to material cost and the non-identification of the pathogen involved. Molecular biology techniques open new perspectives in this field. The evolution of techniques, definitions, and pathogenic approach to septicemia must be revisited as new infectious situations have been identified at the same time as new investigation tools resulting from considerable technological progress. New methods of blood culture have largely contributed to this progress.

  15. Probiotics: an update

    Directory of Open Access Journals (Sweden)

    Yvan Vandenplas

    2015-02-01

    Full Text Available OBJECTIVE: Triggered by the growing knowledge on the link between the intestinal microbiome and human health, the interest in probiotics is ever increasing. The authors aimed to review the recent literature on probiotics, from definitions to clinical benefits, with emphasis on children. SOURCES: Relevant literature from searches of PubMed, CINAHL, and recent consensus statements were reviewed. SUMMARY OF THE FINDINGS: While a balanced microbiome is related to health, an imbalanced microbiome or dysbiosis is related to many health problems both within the gastro-intestinal tract, such as diarrhea and inflammatory bowel disease, and outside the gastro-intestinal tract such as obesity and allergy. In this context, a strict regulation of probiotics with health claims is urgent, because the vast majority of these products are commercialized as food (supplements, claiming health benefits that are often not substantiated with clinically relevant evidence. The major indications of probiotics are in the area of the prevention and treatment of gastro-intestinal related disorders, but more data has become available on extra-intestinal indications. At least two published randomized controlled trials with the commercialized probiotic product in the claimed indication are a minimal condition before a claim can be sustained. Today, Lactobacillus rhamnosus GG and Saccharomyces boulardii are the best-studied strains. Although adverse effects have sporadically been reported, these probiotics can be considered as safe. CONCLUSIONS: Although regulation is improving, more stringent definitions are still required. Evidence of clinical benefit is accumulating, although still missing in many areas. Misuse and use of products that have not been validated constitute potential drawbacks.

  16. Updating river basin models with radar altimetry

    DEFF Research Database (Denmark)

    Michailovsky, Claire Irene B.

    response of a catchment to meteorological forcing. While river discharge cannot be directly measured from space, radar altimetry (RA) can measure water level variations in rivers at the locations where the satellite ground track and river network intersect called virtual stations or VS. In this PhD study...... been between 10 and 35 days for altimetry missions until now. The location of the VS is also not necessarily the point at which measurements are needed. On the other hand, one of the main strengths of the dataset is its availability in near-real time. These characteristics make radar altimetry ideally...... suited for use in data assimilation frameworks which combine the information content from models and current observations to produce improved forecasts and reduce prediction uncertainty. The focus of the second and third papers of this thesis was therefore the use of radar altimetry as update data...

  17. PUMA: The Positional Update and Matching Algorithm

    CERN Document Server

    Line, J L B; Pindor, B; Mitchell, D A; Trott, C M

    2016-01-01

    We present new software to cross-match low-frequency radio catalogues: the Positional Update and Matching Algorithm (PUMA). PUMA combines a positional Bayesian probabilistic approach with spectral matching criteria, allowing for confusing sources in the matching process. We go on to create a radio sky model using PUMA based on the Murchison Widefield Array Commissioning Survey, and are able to automatically cross-match 98.5% of sources. Using the characteristics of this sky model, we create simple simulated mock catalogues on which to test PUMA, and find that PUMA can reliably find the correct spectral indices of sources, along with being able to recover ionospheric offsets. Finally, we use this sky model to calibrate and remove foreground sources from simulated interferometric data, generated using OSKAR (the Oxford University visibility generator). We demonstrate that there is a substantial improvement in foreground source removal when using higher frequency and higher resolution source positions, even when...

  18. [Preoperative fasting guidelines: an update].

    Science.gov (United States)

    López Muñoz, A C; Busto Aguirreurreta, N; Tomás Braulio, J

    2015-03-01

    Anesthesiology societies have issued various guidelines on preoperative fasting since 1990, not only to decrease the incidence of lung aspiration and anesthetic morbidity, but also to increase patient comfort prior to anesthesia. Some of these societies have been updating their guidelines, as such that, since 2010, we now have 2 evidence-based preoperative fasting guidelines available. In this article, an attempt is made to review these updated guidelines, as well as the current instructions for more controversial patients such as infants, the obese, and a particular type of ophthalmic surgery. Copyright © 2014 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Publicado por Elsevier España, S.L.U. All rights reserved.

  19. MEMS Stirling Cooler Development Update

    Science.gov (United States)

    Moran, Matthew E.; Wesolek, Danielle

    2003-01-01

    This presentation provides an update on the effort to build and test a prototype unit of the patented MEMS Stirling cooler concept. A micro-scale regenerator has been fabricated by Polar Thermal Technologies and is currently being integrated into a Stirling cycle simulator at Johns Hopkins University Applied Physics Laboratory. A discussion of the analysis, design, assembly, and test plans for the prototype will be presented.

  20. Biofeedback and Performance: An Update

    Science.gov (United States)

    1984-12-01

    non- biofeedback meditation procedure; a single control was a group untrained in relaxation. It is not clear what instructions if any were given to...and meditation in the treatment of generalized anxiety. Proceedings of the 14th Annual Meeting of the Biofeedback Society of America, 187-189...A Technical Report 658 N BIOFEEDBACK AND PERFORMANCE: Cq AN UPDATE In George H. Lawrence BASIC RESEARCH 6 U.I.S. Army _ Research Institute for the

  1. An update on percutaneous nephrolithotomy

    DEFF Research Database (Denmark)

    Tefekli, A; Cordeiro, E; de la Rosette, J J M C H

    2013-01-01

    Since its introduction in late 1970's, percutaneous nephrolithotomy (PNL) has undergone an evolution in both equipment and technique. This evolution still continues today in the era of minimally invasive treatment options, and is evidenced by the numerous publications. PNL is generally advantageo...... patients managed with PNL worldwide and analyzed the data in detail, producing more than 25 scientific papers. And this update focuses on the lessons learned from the CROES PCNL Global Study....

  2. RELAP-7 Development Updates

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Hongbin [Idaho National Lab. (INL), Idaho Falls, ID (United States); Zhao, Haihua [Idaho National Lab. (INL), Idaho Falls, ID (United States); Gleicher, Frederick Nathan [Idaho National Lab. (INL), Idaho Falls, ID (United States); DeHart, Mark David [Idaho National Lab. (INL), Idaho Falls, ID (United States); Zou, Ling [Idaho National Lab. (INL), Idaho Falls, ID (United States); Andrs, David [Idaho National Lab. (INL), Idaho Falls, ID (United States); Martineau, Richard Charles [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-09-01

    RELAP-7 is a nuclear systems safety analysis code being developed at the Idaho National Laboratory, and is the next generation tool in the RELAP reactor safety/systems analysis application series. RELAP-7 development began in 2011 to support the Risk Informed Safety Margins Characterization (RISMC) Pathway of the Light Water Reactor Sustainability (LWRS) program. The overall design goal of RELAP-7 is to take advantage of the previous thirty years of advancements in computer architecture, software design, numerical methods, and physical models in order to provide capabilities needed for the RISMC methodology and to support nuclear power safety analysis. The code is being developed based on Idaho National Laboratory’s modern scientific software development framework – MOOSE (the Multi-Physics Object-Oriented Simulation Environment). The initial development goal of the RELAP-7 approach focused primarily on the development of an implicit algorithm capable of strong (nonlinear) coupling of the dependent hydrodynamic variables contained in the 1-D/2-D flow models with the various 0-D system reactor components that compose various boiling water reactor (BWR) and pressurized water reactor nuclear power plants (NPPs). During Fiscal Year (FY) 2015, the RELAP-7 code has been further improved with expanded capability to support boiling water reactor (BWR) and pressurized water reactor NPPs analysis. The accumulator model has been developed. The code has also been coupled with other MOOSE-based applications such as neutronics code RattleSnake and fuel performance code BISON to perform multiphysics analysis. A major design requirement for the implicit algorithm in RELAP-7 is that it is capable of second-order discretization accuracy in both space and time, which eliminates the traditional first-order approximation errors. The second-order temporal is achieved by a second-order backward temporal difference, and the one-dimensional second-order accurate spatial discretization

  3. Warthog: Coupling Status Update

    Energy Technology Data Exchange (ETDEWEB)

    Hart, Shane W. D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Reardon, Bradley T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-06-30

    stand-alone BISON run. Future work involves improving the user interface (UI), likely through integration with the Nuclear Energy Advanced Modeling and Simulation (NEAMS) Workbench. Furthermore, automating the input creation would ease the user experience. The next priority is to continue coupling the work with other codes in the SHARP package. Efforts on other projects include work to couple the Nek5000 thermo-hydraulics code to MOOSE, but this is in the preliminary stages.

  4. Receta para el Exito. Una Guia Actualizada para Padres sobre el Mejoramiento de las Escuelas de Colorado y Logros Estudiantiles (Recipe for Success: An Updated Parents' Guide to Improving Colorado Schools and Student Achievement).

    Science.gov (United States)

    Taher, Bonnie; Durr, Pamela

    This Spanish language guide describes ways that parents can help improve student achievement and school quality. It answers such questions as: how to choose the right early-education opportunity for a preschooler; how to make sure a 5-year-old is ready for school; how to help a daughter do well in school; how to work with a daughter's or son's…

  5. Updated SAO OMI formaldehyde retrieval

    Directory of Open Access Journals (Sweden)

    G. González Abad

    2014-01-01

    Full Text Available We present and discuss the Smithsonian Astrophysical Observatory (SAO formaldehyde (H2CO retrieval algorithm for the Ozone Monitoring Instrument (OMI which is the operational retrieval for NASA OMI H2CO. The version of the algorithm described here includes relevant changes with respect to the operational one, including differences in the reference spectra for H2CO, the fit of O2-O2 collisional complex, updates in the high resolution solar reference spectrum, the use of a model reference sector over the remote Pacific Ocean to normalize the retrievals, an updated Air Mass Factor (AMF calculation scheme, and the inclusion of scattering weights and vertical H2CO profile in the level 2 products. The theoretical basis of the retrieval is discussed in detail. Typical values for retrieved vertical columns are between 4 × 1015 and 4 × 1016 molecules cm−2 with typical fitting uncertainties ranging between 40% and 100%. In high concentration regions the errors are usually reduced to 30%. The detection limit is estimated at 3 × 1015 molecules cm−2. These updated retrievals are compared with previous ones.

  6. Update of CERN exchange network

    CERN Multimedia

    2003-01-01

    An update of the CERN exchange network will be done next April. Disturbances or even interruptions of telephony services may occur from 4th to 24th April during evenings from 18:30 to 00:00 but will not exceed more than 4 consecutive hours (see tentative planning below). In addition, the voice messaging system will be shut down on March, 26th April from 18:00 to 00:00. Calls supposed to be routed to the voice messaging system will not be possible during the shutdown. CERN divisions are invited to avoid any change requests (set-ups, move or removals) of telephones and fax machines from 4th to 25th April. Everything will be done to minimize potential inconveniences which may occur during this update. There will be no loss of telephone functionalities. CERN GSM portable phones won't be affected by this change. Should you need more details, please send us your questions by email to Standard.Telephone@cern.ch. Date Change type Affected areas March 26 Update of the voice messaging system All CERN sites April...

  7. NEWS: Post-16 update

    Science.gov (United States)

    1999-05-01

    (post16) Making physics connect Doesn't Melvyn Bragg do a wonderful job, engaging both scientists and artists in sensitive discussion on Radio 4 about their methods and their purposes? But every week teachers have the chance to show their students that physics is a way of seeing the world that is well-connected with other aspects of knowledge and culture. The stakes are high: students who fail to appreciate this generally choose not to study the subject beyond GCSE. Most students find our preoccupation with technical detail off-putting. Accepting that we have a syllabus to cover, it's still a question of balance. In our teaching we should aim for variety in order to find ways to connect with every student's interests. Also, we can show that we (the nearest embodiment of a physicist some students will experience) are multidimensional and so fully human. Most important, teachers need flexibility to both encourage and respond to student comment and questions. The first booklet in the discussion series Shaping the Future takes up these themes. Rich in ideas for both immediate use and the longer term, it aims to stimulate debate and improve teaching. Copies cost £5.50 including postage and are available from Ingrid Ebeyer, Post-16 Initiative, Institute of Physics, 76 Portland Place, London W1N 3DH. How far is it? This question is asked in many family cars and school minibuses at the start of a journey, and answered by most in terms of hours and minutes rather than miles. What a good idea for introducing a social and historical perspective to a lesson on distance, velocity and time. How far can you actually get in a day? What is the range of human activity? Walking for eight hours will get many people about 25 miles. A pack horse will progress at much the same rate, but fast riding or a coach and team of horses will get further. Motorway driving (when the cones are on holiday) would take you nearly 500 miles. The 05.15 am train from Penzance arrives in Inverness at 7

  8. Update on Aromatase Inhibitors

    Directory of Open Access Journals (Sweden)

    Seifert-Klauss V

    2015-01-01

    estrogen withdrawal, such as endometriosis or fibroids, studies have not shown any significant advantage of AI-therapy so far. Bodybuilders use AI inhibitors to prevent estrogenic side effects of a testosterone therapy through conversion in estrogens and to enhance testosterone levels by blocking its metabolisation. Medical application of AI is discussed for boys with short stature as a more cost-effective alternative to treatment with human growth hormone.br Substances: Currently, the 3 commonly used AI are anastrozol, letrozol (both non- steroidal, displaying competitive binding and reversibleinhibition and exemestane (steroidal, inactivation of aromatase through covalent binding, show better anticancerous effects compared with tamoxifene.br Effects: AI decrease estradiol serum levels in postmenopausal women from around 30 pmol/l to 3 pmol/l. Intracellular estrogen-concentrations are reduced, too. Under adjuvant therapy (early breast cancer, this estrogen withdrawal prolongs the time to recurrence, and results in higher rates of disease free survival (absolute reduction of 2.7% after 5 years compared with tamoxifene while the 100-months-analysis of the ATAC-trial did not find an effect on overall survival (ATAC trialists group. In the metastasized situation, a Cochrane-Review-metaanalysis of 31 trials on AI in a total of 11.403 postmenopausal patients with advanced disease showed statistically significant improved survival under AI of 10% in comparison with the other endocrine therapeutic options tamoxifene (TAM, megestrolacetat (MA and medroxyprogesterone acetate (MPA (HR 0.90; 95-%-CI: 0.84–0.97.br Side effects: The most common side effects are hot flushes, joint and bone pain, reduction of bone density, diarrhea and rashes. In women with increased risk for osteoporosis the fracture rate is higher under AI than with the SERM tamoxifene, so that before initiating therapy, a bone density measurement is recommended.br Modes of treatment in breast cancer: Adjuvant

  9. Post-16 update

    Science.gov (United States)

    1999-03-01

    technology lead to new approaches which open up many possibilities. The second thrust must be to have a good supply of apparatus which can be can assembled and manipulated by students to suit their thoughts and purposes. This apparatus may well be rather simple and need not to be very expensive. This may compensate for some of the implied expense of the first thrust above. Alongside these two there will continue to be steady development of traditional apparatus, often used for a demonstration. Affording apparatus. The key to developing the apparatus within a department must be to look towards fewer items, each of which can perform more tasks, deployed as measurement tools. In this the increasing computing power available, often at a small cost, can be deployed intelligently. Following a practice elsewhere we must expect most of this development to take place in software, not the hardware. This has clear implications for the apparatus manufacturers. Low costs in computing have followed from the adoption of the widespread standards that enable one device to be used for many purposes. A similar development seems likely in the provision of apparatus. Some elements are likely to prove expensive. Compensating for the use of these expensive elements will then prove to be the challenge which makes the whole package affordable. Building up a department. Out of the post-16 initiative will come some thoughts developed from Advancing Physics that show how we can move from the current provision. New and effectively deployed apparatus can lead to an improvement in teaching and learning and in students' perceptions of physics. Ian Lawrence

  10. Real time hybrid simulation with online model updating: An analysis of accuracy

    Science.gov (United States)

    Ou, Ge; Dyke, Shirley J.; Prakash, Arun

    2017-02-01

    In conventional hybrid simulation (HS) and real time hybrid simulation (RTHS) applications, the information exchanged between the experimental substructure and numerical substructure is typically restricted to the interface boundary conditions (force, displacement, acceleration, etc.). With additional demands being placed on RTHS and recent advances in recursive system identification techniques, an opportunity arises to improve the fidelity by extracting information from the experimental substructure. Online model updating algorithms enable the numerical model of components (herein named the target model), that are similar to the physical specimen to be modified accordingly. This manuscript demonstrates the power of integrating a model updating algorithm into RTHS (RTHSMU) and explores the possible challenges of this approach through a practical simulation. Two Bouc-Wen models with varying levels of complexity are used as target models to validate the concept and evaluate the performance of this approach. The constrained unscented Kalman filter (CUKF) is selected for using in the model updating algorithm. The accuracy of RTHSMU is evaluated through an estimation output error indicator, a model updating output error indicator, and a system identification error indicator. The results illustrate that, under applicable constraints, by integrating model updating into RTHS, the global response accuracy can be improved when the target model is unknown. A discussion on model updating parameter sensitivity to updating accuracy is also presented to provide guidance for potential users.

  11. Clinical trials update from the Heart Failure Society of America Meeting 2009: FAST, IMPROVE-HF, COACH galectin-3 substudy, HF-ACTION nuclear substudy, DAD-HF, and MARVEL-1.

    Science.gov (United States)

    Lainscak, Mitja; Coletta, Alison P; Sherwi, Nasser; Cleland, John G F

    2010-02-01

    This article presents findings and a commentary on late-breaking trials presented during the meeting of the Heart Failure Society of America in September 2009. Unpublished reports should be considered as preliminary, since analyses may change in the final publication. The FAST trial showed somewhat better performance of intrathoracic impedance for prediction of deterioration in patients with heart failure (HF) when compared with daily weighing. The IMPROVE-HF study reported the benefits of education on the management of patients with systolic HF. Galectin-3 appeared a useful method for improving risk stratification of patients with chronic HF in a substudy of the COACH trial. A nuclear substudy of the HF-ACTION trial failed to demonstrate that resting myocardial perfusion imaging, a measure of myocardial scar and viability, was clinically useful. A small randomized controlled trial (DAD-HF) suggested that the use of low-dose dopamine in patients with acutely decompensated HF was associated with less deterioration in renal function and less hypokalaemia. The MARVEL-1 trial raises further concerns about the safety of myoblast transplantation in ischaemic HF.

  12. Environmental Chemistry Update

    Science.gov (United States)

    1995-08-01

    Human Health Effects of the Chernobyl DisasterIncreased Incidence of Thyroid CancerThe release of radioactivity from the famous explosion at the fission nuclear power reactor at Chernobyl eight years ago has resulted in a substantial increase in the incidence of thyroid cancer in children in the immediate area but no great increase in the incidence of childhood leukemia, tumors, or genetic defects. In the region of the Belarus republic closest to Chernobyl, the childhood thyroid cancer rate has reached over 100 cases per million children, compared to less than 3 per million in most countries. More than 500 children in Belarus and Ukraine have been diagnosed with this disease. The likely cause of the cancers is radioactivity from the isotope 131-I and perhaps 133-I released during the explosion (1). Lead PollutionAnalysis of snow in the Greenland ice sheet indicates rather high levels of lead pollution in air from 500 BC to AD 300 and AD 1000-1500. The earliest lead pollution was associated with mining in Greece and then mining by the Romans, especially in Spain. The later pollution was due mainly to lead and silver smelting in Germany (2). Detrimental Effect of Lead upon IQ in AustraliaStudies of children in Port Pirie, Australia have produced further evidence of the detrimental effect of lead upon IQ. The cumulative exposure to lead of the children from birth to age seven years was determined by analyzing for the element in their baby teeth (3). Ozone Hole PhenomenaThe AntarcticThe Antarctic ozone hole appeared earlier than usual in 1994; it was as large and as severe as the holes in 1992 and 1993. The region of severe depletion covered about 24 million square kilometers, which is approximately the size of North America (4). The Role of Nitric AcidOur knowledge of the role of nitric acid in the formation of ozone holes over polar areas has recently been improved by a joint publication from researchers in Scotland and the United States. Using data obtained by

  13. Updated Mars Mission Architectures Featuring Nuclear Thermal Propulsion

    Science.gov (United States)

    Rodriguez, Mitchell A.; Percy, Thomas K.

    2017-01-01

    Nuclear thermal propulsion (NTP) can potentially enable routine human exploration of Mars and the solar system. By using nuclear fission instead of a chemical combustion process, and using hydrogen as the propellant, NTP systems promise rocket efficiencies roughly twice that of the best chemical rocket engines currently available. The most recent major Mars architecture study featuring NTP was the Design Reference Architecture 5.0 (DRA 5.0), performed in 2009. Currently, the predominant transportation options being considered are solar electric propulsion (SEP) and chemical propulsion; however, given NTP's capabilities, an updated architectural analysis is needed. This paper provides a top-level overview of several different architectures featuring updated NTP performance data. New architectures presented include a proposed update to the DRA 5.0 as well as an investigation of architectures based on the current Evolvable Mars Campaign, which is the focus of NASA's current analyses for the Journey to Mars. Architectures investigated leverage the latest information relating to NTP performance and design considerations and address new support elements not available at the time of DRA 5.0, most notably the Orion crew module and the Space Launch System (SLS). The paper provides a top level quantitative comparison of key performance metrics as well as a qualitative discussion of improvements and key challenges still to be addressed. Preliminary results indicate that the updated NTP architectures can significantly reduce the campaign mass and subsequently the costs for assembly and number of launches.

  14. Model updating in flexible-link multibody systems

    Science.gov (United States)

    Belotti, R.; Caneva, G.; Palomba, I.; Richiedei, D.; Trevisani, A.

    2016-09-01

    The dynamic response of flexible-link multibody systems (FLMSs) can be predicted through nonlinear models based on finite elements, to describe the coupling between rigid- body and elastic behaviour. Their accuracy should be as high as possible to synthesize controllers and observers. Model updating based on experimental measurements is hence necessary. By taking advantage of the experimental modal analysis, this work proposes a model updating procedure for FLMSs and applies it experimentally to a planar robot. Indeed, several peculiarities of the model of FLMS should be carefully tackled. On the one hand, nonlinear models of a FLMS should be linearized about static equilibrium configurations. On the other, the experimental mode shapes should be corrected to be consistent with the elastic displacements represented in the model, which are defined with respect to a fictitious moving reference (the equivalent rigid link system). Then, since rotational degrees of freedom are also represented in the model, interpolation of the experimental data should be performed to match the model displacement vector. Model updating has been finally cast as an optimization problem in the presence of bounds on the feasible values, by also adopting methods to improve the numerical conditioning and to compute meaningful updated inertial and elastic parameters.

  15. Frequency response function-based model updating using Kriging model

    Science.gov (United States)

    Wang, J. T.; Wang, C. J.; Zhao, J. P.

    2017-03-01

    An acceleration frequency response function (FRF) based model updating method is presented in this paper, which introduces Kriging model as metamodel into the optimization process instead of iterating the finite element analysis directly. The Kriging model is taken as a fast running model that can reduce solving time and facilitate the application of intelligent algorithms in model updating. The training samples for Kriging model are generated by the design of experiment (DOE), whose response corresponds to the difference between experimental acceleration FRFs and its counterpart of finite element model (FEM) at selected frequency points. The boundary condition is taken into account, and a two-step DOE method is proposed for reducing the number of training samples. The first step is to select the design variables from the boundary condition, and the selected variables will be passed to the second step for generating the training samples. The optimization results of the design variables are taken as the updated values of the design variables to calibrate the FEM, and then the analytical FRFs tend to coincide with the experimental FRFs. The proposed method is performed successfully on a composite structure of honeycomb sandwich beam, after model updating, the analytical acceleration FRFs have a significant improvement to match the experimental data especially when the damping ratios are adjusted.

  16. Flow Forecasting in Urban Drainage Systems using Deterministic Updating of Water Levels in Distributed Hydraulic Models

    DEFF Research Database (Denmark)

    Hansen, Lisbeth S.; Borup, Morten; Møller, A.;

    2011-01-01

    the performance of the updating procedure for flow forecasting. Measured water levels in combination with rain gauge input are used as basis for the evaluation. When compared to simulations without updating, the results show that it is possible to obtain an improvement in the 20 minute forecast of the water level...... to eliminate some of the unavoidable discrepancies between model and reality. The latter can partly be achieved by using the commercial tool MOUSE UPDATE, which is capable of inserting measured water levels from the system into the distributed, physically based MOUSE model. This study evaluates and documents...

  17. Updating the treatment of recurrent tonsillitis in adults. Review

    OpenAIRE

    Gascón-Rubio, María Cristina; Alonso-Alonso, Albino José

    2016-01-01

    Introduction and Objectives: Acute pharyngitis in adults (APA) is one of the most frequent reasons for consultation in primary care. The main objective of this review is to update the therapeutic options for the prevention and treatment of APA and to determine which interventions have the greatest impact in reducing morbidity and improving the quality of life of patients, which directly affects the consumption of health resources. Material and Methods: First clinical criteria of the FAA, indi...

  18. Nootropic herbs (Medhya Rasayana) in Ayurveda: An update

    OpenAIRE

    2012-01-01

    Cognitive deficits that present with many of neuropsychiatric conditions and/or alone as developmental deficit demand use of nootropics to boost cognitive abilities. Recently there is a tremendous urge to explore medicinal plants globally for improving cognitive function owing to their less adverse effects. Ayurveda provides a list of herbs known for nootropic activity as well as their multi-dimensional utility in various conditions. Present paper is a review to update knowledge on pharmacolo...

  19. Modeling Conservative Updates in Multi-Hash Approximate Count Sketches

    OpenAIRE

    2012-01-01

    Multi-hash-based count sketches are fast and memory efficient probabilistic data structures that are widely used in scalable online traffic monitoring applications. Their accuracy significantly improves with an optimization, called conservative update, which is especially effective when the aim is to discriminate a relatively small number of heavy hitters in a traffic stream consisting of an extremely large number of flows. Despite its widespread application, a thorough u...

  20. Leak detection, monitoring, and mitigation technology trade study update

    Energy Technology Data Exchange (ETDEWEB)

    HERTZEL, J.S.

    1998-11-10

    This document is a revision and update to the initial report that describes various leak detection, monitoring, and mitigation (LDMM) technologies that can be used to support the retrieval of waste from the single-shell tanks (SST) at the Hanford Site. This revision focuses on the improvements in the technical performance of previously identified and useful technologies, and it introduces new technologies that might prove to be useful.

  1. CyanoBase: the cyanobacteria genome database update 2010.

    Science.gov (United States)

    Nakao, Mitsuteru; Okamoto, Shinobu; Kohara, Mitsuyo; Fujishiro, Tsunakazu; Fujisawa, Takatomo; Sato, Shusei; Tabata, Satoshi; Kaneko, Takakazu; Nakamura, Yasukazu

    2010-01-01

    CyanoBase (http://genome.kazusa.or.jp/cyanobase) is the genome database for cyanobacteria, which are model organisms for photosynthesis. The database houses cyanobacteria species information, complete genome sequences, genome-scale experiment data, gene information, gene annotations and mutant information. In this version, we updated these datasets and improved the navigation and the visual display of the data views. In addition, a web service API now enables users to retrieve the data in various formats with other tools, seamlessly.

  2. Long-Acting Growth Hormone: An Update.

    Science.gov (United States)

    Saenger, Paul H; Mejia-Corletto, Jorge

    2016-01-01

    After the introduction of recombinant human growth hormone (rhGH) in 1985, a myriad of children and adults have benefited from its growth-promoting and metabolic effects. Nowadays, current therapeutic regimens rely on daily subcutaneous GH injections that could be burdensome and inconvenient to pediatric patients. As expected with any long-term parenteral pharmacological treatment, these daily regimens may promote nonadherence, poor compliance, treatment abandonment and/or suboptimal clinical outcomes. In order to improve patient and caregiver acceptance of proposed regimens, simplified dosing schedules could potentially aid in reducing poor compliance and maximize the therapeutic end results. Long-acting GH formulations have been designed and perfected over the last two decades, and currently there are several formulations in advanced stages of research as a reasonable attempt to improve patient's adherence to GH treatment. A long-acting GH preparation allowing for reduced injection frequency is likely to improve treatment adherence and to decrease the distress and inconvenience associated with daily injections. This review presents an update about the status of current and recent efforts that have enabled the formulation of sustained-release, long-acting rhGH as it has been longed for many years in the pediatric endocrinology field.

  3. Experimental model updating using frequency response functions

    Science.gov (United States)

    Hong, Yu; Liu, Xi; Dong, Xinjun; Wang, Yang; Pu, Qianhui

    2016-04-01

    In order to obtain a finite element (FE) model that can more accurately describe structural behaviors, experimental data measured from the actual structure can be used to update the FE model. The process is known as FE model updating. In this paper, a frequency response function (FRF)-based model updating approach is presented. The approach attempts to minimize the difference between analytical and experimental FRFs, while the experimental FRFs are calculated using simultaneously measured dynamic excitation and corresponding structural responses. In this study, the FRF-based model updating method is validated through laboratory experiments on a four-story shear-frame structure. To obtain the experimental FRFs, shake table tests and impact hammer tests are performed. The FRF-based model updating method is shown to successfully update the stiffness, mass and damping parameters of the four-story structure, so that the analytical and experimental FRFs match well with each other.

  4. De vis wordt duur(zaam) vervoerd : Openbare eindrapportage AKK-project ACD-03.032

    NARCIS (Netherlands)

    Snels, J.C.M.A.

    2005-01-01

    The project `De vis wordt duur(zaam) vervoerd` focuses on the reduction of the amount of driven kilometres in de supply from producers (i.e. Prime Meat and Seafood Partners) to the wholesaler and the distribution routes of the wholesaler (i.e. Deli XL). The reduction can be reached through (1) chang

  5. De vis wordt duur(zaam) vervoerd : Openbare eindrapportage AKK-project ACD-03.032

    NARCIS (Netherlands)

    Snels, J.C.M.A.

    2005-01-01

    The project `De vis wordt duur(zaam) vervoerd` focuses on the reduction of the amount of driven kilometres in de supply from producers (i.e. Prime Meat and Seafood Partners) to the wholesaler and the distribution routes of the wholesaler (i.e. Deli XL). The reduction can be reached through (1) chang

  6. Fusarium ründab igast asendist / Elina Akk, Heino Lõiveke

    Index Scriptorium Estoniae

    Akk, Elina, 1968-

    2012-01-01

    Seeneperekond Fusarium spp. toodab toksilisi mükotoksiine ja põhjustab üle maailma suuri saagikadusid. Uute ning ohtlikumate Fusarium'i liikide levik teraviljakasvatuses üha laieneb, ka Põhja- ja Baltimaades

  7. Fusarium ründab igast asendist / Elina Akk, Heino Lõiveke

    Index Scriptorium Estoniae

    Akk, Elina, 1968-

    2012-01-01

    Seeneperekond Fusarium spp. toodab toksilisi mükotoksiine ja põhjustab üle maailma suuri saagikadusid. Uute ning ohtlikumate Fusarium'i liikide levik teraviljakasvatuses üha laieneb, ka Põhja- ja Baltimaades

  8. Updating systematic reviews: an international survey.

    Directory of Open Access Journals (Sweden)

    Chantelle Garritty

    Full Text Available BACKGROUND: Systematic reviews (SRs should be up to date to maintain their importance in informing healthcare policy and practice. However, little guidance is available about when and how to update SRs. Moreover, the updating policies and practices of organizations that commission or produce SRs are unclear. METHODOLOGY/PRINCIPAL FINDINGS: The objective was to describe the updating practices and policies of agencies that sponsor or conduct SRs. An Internet-based survey was administered to a purposive non-random sample of 195 healthcare organizations within the international SR community. Survey results were analyzed using descriptive statistics. The completed response rate was 58% (n = 114 from across 26 countries with 70% (75/107 of participants identified as producers of SRs. Among responders, 79% (84/107 characterized the importance of updating as high or very-high and 57% (60/106 of organizations reported to have a formal policy for updating. However, only 29% (35/106 of organizations made reference to a written policy document. Several groups (62/105; 59% reported updating practices as irregular, and over half (53/103 of organizational respondents estimated that more than 50% of their respective SRs were likely out of date. Authors of the original SR (42/106; 40% were most often deemed responsible for ensuring SRs were current. Barriers to updating included resource constraints, reviewer motivation, lack of academic credit, and limited publishing formats. Most respondents (70/100; 70% indicated that they supported centralization of updating efforts across institutions or agencies. Furthermore, 84% (83/99 of respondents indicated they favoured the development of a central registry of SRs, analogous to efforts within the clinical trials community. CONCLUSIONS/SIGNIFICANCE: Most organizations that sponsor and/or carry out SRs consider updating important. Despite this recognition, updating practices are not regular, and many organizations lack

  9. Airborne Network Optimization with Dynamic Network Update

    Science.gov (United States)

    2015-03-26

    AIRBORNE NETWORK OPTIMIZATION WITH DYNAMIC NETWORK UPDATE THESIS Bradly S. Paul, Capt, USAF AFIT-ENG-MS-15-M-030 DEPARTMENT OF THE AIR FORCE AIR...to copyright protection in the United States. AFIT-ENG-MS-15-M-030 AIRBORNE NETWORK OPTIMIZATION WITH DYNAMIC NETWORK UPDATE THESIS Presented to the...NETWORK OPTIMIZATION WITH DYNAMIC NETWORK UPDATE Bradly S. Paul, B.S.C.P. Capt, USAF Committee Membership: Maj Thomas E. Dube Chair Dr. Kenneth M. Hopkinson

  10. Surveillance, response systems, and evidence updates on emerging zoonoses: the role of one health

    OpenAIRE

    2013-01-01

    Globally, emerging zoonotic diseases are increasing. Existing surveillance systems for zoonoses have substantial gaps, especially in developing countries, and the systems in place in the developed world require improvements. Resources and updates on evidence-based practice (EBP) for zoonoses are sparser in the veterinary literature as compared to the medical literature. Evidence updates for emerging zoonoses are either absent or rudimentary in both human and veterinary medicine. A ‘one-health...

  11. Towards cost-sensitive adaptation: when is it worth updating your predictive model?

    OpenAIRE

    Zliobaite, Indre; Budka, Marcin; Stahl, Frederic

    2015-01-01

    Our digital universe is rapidly expanding, more and more daily activities are digitally recorded, data arrives in streams, it needs to be analyzed in real time and may evolve over time. In the last decade many adaptive learning algorithms and prediction systems, which can automatically update themselves with the new incoming data, have been developed. The majority of those algorithms focus on improving the predictive performance and assume that model update is always desired as soon as possib...

  12. The primordial helium abundance from updated emissivities

    Energy Technology Data Exchange (ETDEWEB)

    Aver, Erik [Department of Physics, Gonzaga University, 502 E Boone Ave, Spokane, WA, 99258 (United States); Olive, Keith A.; Skillman, Evan D. [School of Physics and Astronomy, University of Minnesota, 116 Church St. SE, Minneapolis, MN, 55455 (United States); Porter, R.L., E-mail: aver@gonzaga.edu, E-mail: olive@umn.edu, E-mail: ryanlporter@gmail.com, E-mail: skillman@astro.umn.edu [Department of Physics and Astronomy, University of Georgia, Athens, GA, 30602 (United States)

    2013-11-01

    Observations of metal-poor extragalactic H II regions allow the determination of the primordial helium abundance, Y{sub p}. The He I emissivities are the foundation of the model of the H II region's emission. Porter, Ferland, Storey, and Detisch (2012) have recently published updated He I emissivities based on improved photoionization cross-sections. We incorporate these new atomic data and update our recent Markov Chain Monte Carlo analysis of the dataset published by Izotov, Thuan, and Stasi'nska (2007). As before, cuts are made to promote quality and reliability, and only solutions which fit the data within 95% confidence level are used to determine the primordial He abundance. The previously qualifying dataset is almost entirely retained and with strong concordance between the physical parameters. Overall, an upward bias from the new emissivities leads to a decrease in Y{sub p}. In addition, we find a general trend to larger uncertainties in individual objects (due to changes in the emissivities) and an increased variance (due to additional objects included). From a regression to zero metallicity, we determine Y{sub p} = 0.2465 ± 0.0097, in good agreement with the BBN result, Y{sub p} = 0.2485 ± 0.0002, based on the Planck determination of the baryon density. In the future, a better understanding of why a large fraction of spectra are not well fit by the model will be crucial to achieving an increase in the precision of the primordial helium abundance determination.

  13. Updates

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Chinese Academy of Social Sciences released the "China Industry Competitiveness Report (2012) NO.2", Guo Chaoxian, deputy director of Industrial Organization Office of Academy of Social Sciences Institute of Industrial Economics, said that textile and garmentindustry was China's most competitive industries, product market share ranked the second in the world, while productivity was 14 times of the United States. Guo Chaoxian noted that China's textile and garment industry was the most competitive national industry, no matter in terms of international market share, trade competitiveness index, the real index of comparative advantage, all were regarded as the strongest in the world. China's textile and garment industry's market share came in the second in the world, six times of Italy, seven times of Germany and twelve times of the United States.

  14. Updates

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    2011 Chinese online shopping industry continues the momentum of rapid development in 2010, gradually narrowing the gap of the online shopping environment in the region, online shopping growth in some of the second and third tier provinces performed outstandingly. According to the iResearch ECPlus monitoring data,

  15. An update on chemistry analyzers.

    Science.gov (United States)

    Vap, L M; Mitzner, B

    1996-09-01

    This update of six chemistry analyzers available to the clinician discusses several points that should be considered prior to the purchase of equipment. General topics include how to best match an instrument to clinic needs and the indirect costs associated with instrument operation. Quality assurance recommendations are discussed and common terms are defined. Specific instrument features, principles of operation, performance, and costs are presented. The information provided offers potential purchasers an objective approach to the evaluation of a chemistry analyzer for the veterinary clinic.

  16. Los Alamos Climatology 2016 Update

    Energy Technology Data Exchange (ETDEWEB)

    Bruggeman, David Alan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-02-10

    The Los Alamos National Laboratory (LANL or the Laboratory) operates a meteorology monitoring network to support LANL emergency response, engineering designs, environmental compliance, environmental assessments, safety evaluations, weather forecasting, environmental monitoring, research programs, and environmental restoration. Weather data has been collected in Los Alamos since 1910. Bowen (1990) provided climate statistics (temperature and precipitation) for the 1961– 1990 averaging period, and included other analyses (e.g., wind and relative humidity) based on the available station locations and time periods. This report provides an update to the 1990 publication Los Alamos Climatology (Bowen 1990).

  17. Primary Anorectal Melanoma: An Update

    Directory of Open Access Journals (Sweden)

    P Carcoforo, M.T Raiji, G.M Palini, M Pedriali, U Maestroni, G Soliani, A Detroia, M.V Zanzi, A.L Manna, J.G Crompton, R.C Langan, A Stojadinovic, I Avital

    2012-01-01

    Full Text Available The anorectum is a rare anatomic location for primary melanoma. Mucosal melanoma is a distinct biological and clinical entity from the more common cutaneous melanoma. It portrays worse prognosis than cutaneous melanoma, with distant metastases being the overwhelming cause of morbidity and mortality. Surgery is the treatment of choice, but significant controversy exists over the extent of surgical resection. We present an update on the state of the art of anorectal mucosal melanoma. To illustrate the multimodality approach to anorectal melanoma, we present a typical patient.

  18. Communication technology update and fundamentals

    CERN Document Server

    Grant, August E

    2014-01-01

    A classic now in its 14th edition, Communication Technology Update and Fundamentals is the single best resource for students and professionals looking to brush up on how these technologies have developed, grown, and converged, as well as what's in store for the future. It begins by developing the communication technology framework-the history, ecosystem, and structure-then delves into each type of technology, including everything from mass media, to computers and consumer electronics, to networking technologies. Each chapter is written by faculty and industry experts who p

  19. Nordic MCL2 trial update

    DEFF Research Database (Denmark)

    Geisler, Christian H; Kolstad, Arne; Laurell, Anna

    2012-01-01

    Mantle cell lymphoma (MCL) is a heterogenic non-Hodgkin lymphoma entity, with a median survival of about 5 years. In 2008 we reported the early - based on the median observation time of 4 years - results of the Nordic Lymphoma Group MCL2 study of frontline intensive induction immunochemotherapy...... and autologous stem cell transplantation (ASCT), with more than 60% event-free survival at 5 years, and no subsequent relapses reported. Here we present an update after a median observation time of 6·5 years. The overall results are still excellent, with median overall survival and response duration longer than...

  20. Model Updating Nonlinear System Identification Toolbox Project

    Data.gov (United States)

    National Aeronautics and Space Administration — ZONA Technology (ZONA) proposes to develop an enhanced model updating nonlinear system identification (MUNSID) methodology that utilizes flight data with...

  1. Federal Geothermal Research Program Update, FY 2000

    Energy Technology Data Exchange (ETDEWEB)

    Renner, Joel Lawrence

    2001-08-01

    The Department of Energy's Geothermal Program serves two broad purposes: 1) to assist industry in overcoming near-term barriers by conducting cost-shared research and field verification that allows geothermal energy to compete in today's aggressive energy markets; and 2) to undertake fundamental research with potentially large economic payoffs. The four categories of work used to distinguish the research activities of the Geothermal Program during FY 2000 reflect the main components of real-world geothermal projects. These categories form the main sections of the project descriptions in this Research Update. Exploration Technology research focuses on developing instruments and techniques to discover hidden hydrothermal systems and to explore the deep portions of known systems. Research in geophysical and geochemical methods is expected to yield increased knowledge of hidden geothermal systems. Reservoir Technology research combines laboratory and analytical investigations with equipment development and field testing to establish practical tools for resource development and management for both hydrothermal reservoirs and enhanced geothermal systems. Research in various reservoir analysis techniques is generating a wide range of information that facilitates development of improved reservoir management tools. Drilling Technology focuses on developing improved, economic drilling and completion technology for geothermal wells. Ongoing research to avert lost circulation episodes in geothermal drilling is yielding positive results. Conversion Technology research focuses on reducing costs and improving binary conversion cycle efficiency, to permit greater use of the more abundant moderate-temperature geothermal resource, and on the development of materials that will improve the operating characteristics of many types of geothermal energy equipment. Increased output and improved performance of binary cycles will result from investigations in heat cycle research.

  2. The digallane molecule, Ga2H6: experimental update giving an improved structure and estimate of the enthalpy change for the reaction Ga2H6(g) --> 2GaH3(g).

    Science.gov (United States)

    Downs, Anthony J; Greene, Tim M; Johnsen, Emma; Pulham, Colin R; Robertson, Heather E; Wann, Derek A

    2010-06-28

    Improved methods of analysis and new quantum chemical calculations have been applied to the results of earlier gas-phase electron diffraction (GED) studies of digallane to give what is judged to be the most realistic structure available to date. The principal distances (r(a3,1) in pm) and interbond angles (angle(a3,1) in deg) are as follows (t = terminal, b = bridging): r(Ga...Ga) 254.9(2), r(Ga-H(t)) 155.0(6), r(Ga-H(b)) 172.3(6), angleGa-H(b)-Ga 95.4(5), and angleH(t)-Ga-H(t) 128.6(9). Scrutiny of the IR spectra of solid Ar matrices doped with the vapour above solid samples of gallane at temperatures in the range 190-220 K reveals the presence of not only Ga(2)H(6) as the major component, but also a significant fraction of the monomer GaH(3). Analysis of the relative proportions of the two molecules evaporating from the solid at different temperatures has led to a first experimental estimate of 59 +/- 16 kJ mol(-1) for the enthalpy change associated with the reaction Ga(2)H(6)(g) --> 2GaH(3)(g). Together with a value of 52 kJ mol(-1) delivered by fresh calculations at the MP2 level, this implies that the stability of the dimer with respect to dissociation has been overrated by earlier theoretical treatments.

  3. Update and revision of WHO air quality guidelines for Europe

    Energy Technology Data Exchange (ETDEWEB)

    Younes, M. [WHO European Centre for Environment and Health, Bilthoven (Netherlands). Bilthoven Div.

    1995-12-31

    The WHO Air Quality Guidelines for Europe (AQG), published in 1987, have provided a uniform basis for the development of strategies for the control of air pollution, and have contributed to the maintenance and improvement of public health in several countries. The aim of the guidelines is to provide a basis for protecting public health from adverse effects of air pollutants, and for eliminating or reducing to a minimum, those contaminants that are known or likely to be hazardous to human health and wellbeing. Since the publication of the first edition of the AQG, new scientific data in the fields of air pollution toxicology and epidemiology have accumulated and new developments in risk assessment methodologies have taken place, requiring updating and/or revision of the existing guidelines. This fact was recognized during the preparation of the initial work plan of the European Centre for Environment and Health, and it was recommended that the Centre undertake any necessary amendments and extensions to the Air Quality Guidelines. The updating procedure is being carried out in cooperation with the International Programme on Chemical Safety (IPCS) and the Commission of the European Communities (CEC) and will be implemented through working group meetings which require the preparation of working documents on specific air pollutants or mixtures and a final consultation to discuss the updated document.It was initiated by a Planning Meeting which was organized in January 1993. The purpose of the planning meeting was to set the framework for the updating and revision process, in particular to discuss the scope and purpose, the contents and the format of the revised AQG publication, to define the details of and the time schedule for the updating process and to identify the working groups needed and their way of operation. (author)

  4. Improving machinery reliability

    CERN Document Server

    Bloch, Heinz P

    1998-01-01

    This totally revised, updated and expanded edition provides proven techniques and procedures that extend machinery life, reduce maintenance costs, and achieve optimum machinery reliability. This essential text clearly describes the reliability improvement and failure avoidance steps practiced by best-of-class process plants in the U.S. and Europe.

  5. Alternative energies. Updates on progress

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, German (ed.) [CIRCE - Centre of Research for Energy Resources and Consumption, Zaragoza (Spain)

    2013-07-01

    Presents fundamental and applied research of alternative energies. Address key pillars in the alternative energy field, such as: biomass energy, hydrogen energy, solar energy, wind energy, hydroelectric power, geothermal energy and their environmental implications, with the most updated progress. Includes the life cycle assessment and thermoeconomic analysis as tools for evaluating and optimising environmental and cost subjects. This book presents nine chapters based on fundamental and applied research of alternative energies. At the present time, the challenge is that technology has to come up with solutions that can provide environmentally friendly energy supply options that are able to cover the current world energy demand. Experts around the world are working on these issues for providing new solutions that will break the existing technological barriers. This book aims to address key pillars in the alternative energy field, such as: biomass energy, hydrogen energy, solar energy, wind energy, hydroelectric power, geothermal energy and their environmental implications, with the most updated progress for each pillar. It also includes the life cycle assessment (LCA) and thermoeconomic analysis (TA) as tools for evaluating and optimising environmental and cost subjects. Chapters are organized into fundamental research, applied research and future trends; and written for engineers, academic researches and scientists.

  6. Experimental Studies on Finite Element Model Updating for a Heated Beam-Like Structure

    Directory of Open Access Journals (Sweden)

    Kaipeng Sun

    2015-01-01

    Full Text Available An experimental study was made for the identification procedure of time-varying modal parameters and the finite element model updating technique of a beam-like thermal structure in both steady and unsteady high temperature environments. An improved time-varying autoregressive method was proposed first to extract the instantaneous natural frequencies of the structure in the unsteady high temperature environment. Based on the identified modal parameters, then, a finite element model for the structure was updated by using Kriging meta-model and optimization-based finite-element model updating method. The temperature-dependent parameters to be updated were expressed as low-order polynomials of temperature increase, and the finite element model updating problem was solved by updating several coefficients of the polynomials. The experimental results demonstrated the effectiveness of the time-varying modal parameter identification method and showed that the instantaneous natural frequencies of the updated model well tracked the trends of the measured values with high accuracy.

  7. Training working memory updating in young adults.

    Science.gov (United States)

    Linares, Rocío; Borella, Erika; Lechuga, M Teresa; Carretti, Barbara; Pelegrina, Santiago

    2017-03-09

    Working memory updating (WMU) is a core mechanism in the human mental architecture and a good predictor of a wide range of cognitive processes. This study analyzed the benefits of two different WMU training procedures, near transfer effects on a working memory measure, and far transfer effects on nonverbal reasoning. Maintenance of any benefits a month later was also assessed. Participants were randomly assigned to: an adaptive training group that performed two numerical WMU tasks during four sessions; a non-adaptive training group that performed the same tasks but on a constant and less demanding level of difficulty; or an active control group that performed other tasks unrelated with working memory. After the training, all three groups showed improvements in most of the tasks, and these benefits were maintained a month later. The gain in one of the two WMU measures was larger for the adaptive and non-adaptive groups than for the control group. This specific gain in a task similar to the one trained would indicate the use of a better strategy for performing the task. Besides this nearest transfer effect, no other transfer effects were found. The adaptability of the training procedure did not produce greater improvements. These results are discussed in terms of the training procedure and the feasibility of training WMU.

  8. Updating Technical Screens for PV Interconnection: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Coddington, M.; Ellis, A.; Lynn, K.; Razon, A.; Key, T.; Kroposki, B.; Mather, B.; Hill, R.; Nicole, K.; Smith, J.

    2012-08-01

    Solar photovoltaics (PV) is the dominant type of distributed generation (DG) technology interconnected to electric distribution systems in the United States, and deployment of PV systems continues to increase rapidly. Considering the rapid growth and widespread deployment of PV systems in United States electric distribution grids, it is important that interconnection procedures be as streamlined as possible to avoid unnecessary interconnection studies, costs, and delays. Because many PV interconnection applications involve high penetration scenarios, the process needs to allow for a sufficiently rigorous technical evaluation to identify and address possible system impacts. Existing interconnection procedures are designed to balance the need for efficiency and technical rigor for all DG. However, there is an implicit expectation that those procedures will be updated over time in order to remain relevant with respect to evolving standards, technology, and practical experience. Modifications to interconnection screens and procedures must focus on maintaining or improving safety and reliability, as well as accurately allocating costs and improving expediency of the interconnection process. This paper evaluates the origins and usefulness of the capacity penetration screen, offers potential short-term solutions which could effectively allow fast-track interconnection to many PV system applications, and considers longer-term solutions for increasing PV deployment levels in a safe and reliable manner while reducing or eliminating the emphasis on the penetration screen.

  9. The LANDFIRE Refresh strategy: updating the national dataset

    Science.gov (United States)

    Nelson, Kurtis J.; Connot, Joel A.; Peterson, Birgit E.; Martin, Charley

    2013-01-01

    The LANDFIRE Program provides comprehensive vegetation and fuel datasets for the entire United States. As with many large-scale ecological datasets, vegetation and landscape conditions must be updated periodically to account for disturbances, growth, and natural succession. The LANDFIRE Refresh effort was the first attempt to consistently update these products nationwide. It incorporated a combination of specific systematic improvements to the original LANDFIRE National data, remote sensing based disturbance detection methods, field collected disturbance information, vegetation growth and succession modeling, and vegetation transition processes. This resulted in the creation of two complete datasets for all 50 states: LANDFIRE Refresh 2001, which includes the systematic improvements, and LANDFIRE Refresh 2008, which includes the disturbance and succession updates to the vegetation and fuel data. The new datasets are comparable for studying landscape changes in vegetation type and structure over a decadal period, and provide the most recent characterization of fuel conditions across the country. The applicability of the new layers is discussed and the effects of using the new fuel datasets are demonstrated through a fire behavior modeling exercise using the 2011 Wallow Fire in eastern Arizona as an example.

  10. Efficient compensation handling via subjective updates

    NARCIS (Netherlands)

    J. Dedeić (Jovana); J. Pantović (Jovanka); J.A. Pérez Parra (Jorge)

    2017-01-01

    textabstractProgramming abstractions for compensation handling and dynamic update are crucial in specifying reliable interacting systems, such as Collective Adaptive Systems (CAS). Compensations and updates both specify how a system reacts in response to exceptional events. Prior work showed that

  11. 76 FR 22618 - Product List Update

    Science.gov (United States)

    2011-04-22

    ... From the Federal Register Online via the Government Publishing Office ] POSTAL REGULATORY COMMISSION 39 CFR Part 3020 Product List Update AGENCY: Postal Regulatory Commission. ACTION: Final rule. SUMMARY: The Commission is updating the postal product lists. This action reflects the disposition of...

  12. Non-Linear Approximation of Bayesian Update

    KAUST Repository

    Litvinenko, Alexander

    2016-06-23

    We develop a non-linear approximation of expensive Bayesian formula. This non-linear approximation is applied directly to Polynomial Chaos Coefficients. In this way, we avoid Monte Carlo sampling and sampling error. We can show that the famous Kalman Update formula is a particular case of this update.

  13. 10 CFR 26.57 - Authorization update.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Authorization update. 26.57 Section 26.57 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.57 Authorization update. (a) Before granting authorization to an individual whose authorization has been interrupted...

  14. 34 CFR 668.55 - Updating information.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Updating information. 668.55 Section 668.55 Education... Information § 668.55 Updating information. (a)(1) Unless the provisions of paragraph (a)(2) or (a)(3) of this... applicant to verify the information contained in his or her application for assistance in an award year...

  15. Census in Schools Educator Update, March 2009

    Science.gov (United States)

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1)…

  16. Better Plants Progress Update Fall 2013

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2013-09-23

    This Progress Update summarizes the significant energy saving achievements and cumulative cost savings made by these industry leaders from 2010-2012. The update also shares the plans and priorities over the next year for the Better Plants Program to continue to advance energy efficiency in the industrial sector.

  17. Gemini Planet Imager Calibrations, Pipeline Updates, and Campaign Data Processing

    Science.gov (United States)

    Perrin, Marshall D.; Follette, Katherine B.; Millar-Blanchaer, Max; Wang, Jason; Wolff, Schulyer; Hung, Li-Wei; Arriaga, Pauline; Savransky, Dmitry; Bailey, Vanessa P.; Bruzzone, Sebastian; Chilcote, Jeffrey K.; De Rosa, Robert J.; Draper, Zachary; Fitzgerald, Michael P.; Greenbaum, Alexandra; Ingraham, Patrick; Konopacky, Quinn M.; Macintosh, Bruce; Marchis, Franck; Marois, Christian; Maire, Jerome; Nielsen, Eric L.; Rajan, Abhijith; Rameau, Julien; Rantakyro, Fredrik; Ruffio, Jean-Baptise; Tran, Debby; Ward-Duong, Kimberly; Zalesky, Joe; GPIES Team

    2017-01-01

    In support of GPI imaging and spectroscopy of exoplanets, polarimetry of disks, and the ongoing Exoplanet Survey we continue to refine calibrations, improve data reduction methods, and develop other enhancements to the data pipeline. We summarize here the latest updates to the open-source GPI Data Reduction Pipeline, including recent improvements spectroscopic and photometric calibrations and polarimetric data processing. For the GPI Exoplanet Survey we have incorporated the GPI Data Pipeline into a larger campaign data system that provides automatic data processing including rapid PSF subtraction and contrast measurements in real time during observations and fully automated PSF subtractions using several state-of-the-art algorithms shortly after each observation completes.

  18. Situation Update: Summary of Weekly FluView

    Science.gov (United States)

    ... Seasonal Avian Swine/Variant Pandemic Other Get Email Updates To receive email updates about this page, enter ... Submit What's this? Submit Button Past Newsletters Situation Update: Summary of Weekly FluView Report Language: English Españ ...

  19. Reliability analysis and updating of deteriorating systems with subset simulation

    DEFF Research Database (Denmark)

    Schneider, Ronald; Thöns, Sebastian; Straub, Daniel

    2017-01-01

    Bayesian updating of the system deterioration model. The updated system reliability is then obtained through coupling the updated deterioration model with a probabilistic structural model. The underlying high-dimensional structural reliability problems are solved using subset simulation, which...

  20. A last updating evolution model for online social networks

    Science.gov (United States)

    Bu, Zhan; Xia, Zhengyou; Wang, Jiandong; Zhang, Chengcui

    2013-05-01

    As information technology has advanced, people are turning to electronic media more frequently for communication, and social relationships are increasingly found on online channels. However, there is very limited knowledge about the actual evolution of the online social networks. In this paper, we propose and study a novel evolution network model with the new concept of “last updating time”, which exists in many real-life online social networks. The last updating evolution network model can maintain the robustness of scale-free networks and can improve the network reliance against intentional attacks. What is more, we also found that it has the “small-world effect”, which is the inherent property of most social networks. Simulation experiment based on this model show that the results and the real-life data are consistent, which means that our model is valid.

  1. Strategies for monitoring and updating clinical practice guidelines: a systematic review

    Directory of Open Access Journals (Sweden)

    Martínez García Laura

    2012-11-01

    Full Text Available Abstract Background Scientific knowledge is in constant change. The flow of new information requires a frequent re-evaluation of the available research results. Clinical practice guidelines (CPGs are not exempted from this phenomenon and need to be kept updated to maintain the validity of their recommendations. The objective of our review is to systematically identify, describe and assess strategies for monitoring and updating CPGs. Study design and setting We conducted a systematic review of studies evaluating one or more methods of updating (with or without monitoring CPGs or recommendations. We searched MEDLINE (PubMed and The Cochrane Methodology Register (The Cochrane Library from 1966 to June 2012. Additionally, we hand-searched reference lists of the included studies and the Guidelines International Network book of abstracts. If necessary, we contacted study authors to obtain additional information. Results We included a total of eight studies. Four evaluated if CPGs were out of date, three updated CPGs, and one continuously monitored and updated CPGs. The most detailed reported phase of the process was the identification of new evidence. As opposed to studies updating guidelines, studies evaluating if CPGs were out of date applied restricted searches. Only one study compared a restricted versus an exhaustive search suggesting that a restricted search is sufficient to assess recommendations’ Validity. One study analyzed the survival time of CPGs and suggested that these should be reassessed every three years. Conclusions There is limited evidence about the optimal strategies for monitoring and updating clinical practice guidelines. A restricted search is likely to be sufficient to monitor new evidence and assess the need to update, however, more information is needed about the timing and type of search. Only the exhaustive search strategy has been assessed for the update of CPGs. The development and evaluation of more efficient

  2. Update of Part 61 Impacts Analysis Methodology. Methodology report. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Oztunali, O.I.; Roles, G.W.

    1986-01-01

    Under contract to the US Nuclear Regulatory Commission, the Envirosphere Company has expanded and updated the impacts analysis methodology used during the development of the 10 CFR Part 61 rule to allow improved consideration of the costs and impacts of treatment and disposal of low-level waste that is close to or exceeds Class C concentrations. The modifications described in this report principally include: (1) an update of the low-level radioactive waste source term, (2) consideration of additional alternative disposal technologies, (3) expansion of the methodology used to calculate disposal costs, (4) consideration of an additional exposure pathway involving direct human contact with disposed waste due to a hypothetical drilling scenario, and (5) use of updated health physics analysis procedures (ICRP-30). Volume 1 of this report describes the calculational algorithms of the updated analysis methodology.

  3. Updated Starshade Technology Gap List

    Science.gov (United States)

    Crill, Brendan P.; Siegler, Nicholas

    2017-01-01

    NASA's Exoplanet Exploration Program (ExEP) guides the development of technology that enables the direct imaging and characterization of exo-Earths in the habitable zone of their stars, for future space observatories. Here we present the Starshade portion of the 2017 ExEP Enabling Technology Gap List, an annual update to ExEP's list of of technology to be advanced in the next 1-5 years. A Starshade is an external occulter on an independent spacecraft, allowing a space telescope to achieve exo-Earth imaging contrast requirements by blocking starlight before it enters the telescope. Building and operating a Starshade requires new technology: the occulter is a structure tens of meters in diameter that must be positioned precisely at a distance of tens of thousands of kilometers from the telescope. We review the current state-of-the-art performance and the performance level that must be achieved for a Starshade.

  4. [An update on Lassa virus].

    Science.gov (United States)

    Leparc-Goffart, I; Emonet, S F

    2011-12-01

    Lassa virus, the etiologic agent of Lassa hemorrhagic fever, infects 100,000 to 300,000 people every year in West Africa with an overall mortality rate ranging from 1 to 2%. It was discovered in 1969 and remains a significant public health risk in endemic areas. Because airborne transmission is possible and mortality can be high under certain conditions, Lassa virus has been classified as a category A bioterrorism agent. Early diagnosis is difficult due to insidious non-specific onset and to the great genetic divergence of the virus that makes RT-PCR assays unreliable. The lack of proper diagnostic tools promotes nosocomial infection and diminishes the efficacy of treatment. Recently, numerous advances have been made in the development of both diagnostic and vaccination techniques. The purpose of this review is to present an update on that research as well as the current epidemiology of Lassa virus.

  5. Update in pulmonary arterial hypertension.

    Science.gov (United States)

    Mejía Chew, C R; Alcolea Batres, S; Ríos Blanco, J J

    2016-11-01

    Pulmonary arterial hypertension is a rare and progressive disease that mainly affects the pulmonary arterioles (precapillary), regardless of the triggering aetiology. The prevalence of pulmonary hypertension and pulmonary arterial hypertension in Spain is estimated at 19.2 and 16 cases per million inhabitants, respectively. The diagnosis of pulmonary arterial hypertension is based on haemodynamic criteria (mean pulmonary artery pressure ≥25mmHg, pulmonary capillary wedge pressure ≤15mmHg and pulmonary vascular resistance >3 Wood units) and therefore requires the implementation of right cardiac catheterisation. Sequential therapy with a single drug has been used in clinical practice. However, recent European guidelines recommend combined initial therapy in some situations. This review conducts a critical update of our knowledge of this disease according to the latest guidelines and recommendations.

  6. Sepsis: An update in management.

    Science.gov (United States)

    Galen, Benjamin T; Sankey, Christopher

    2015-11-01

    Hospitalists are a critical link in providing evidence-based care for patients with sepsis across the disease spectrum, from early recognition to recovery. The past decade of sepsis research has led to significant findings that will change clinical practice for hospital medicine practitioners. Although the incidence of severe sepsis in the United States has continued to rise, in-hospital mortality has declined. Management of the spectrum of sepsis disorders is no longer restricted to the intensive care unit (ICU). This review article will provide an update in the management of sepsis for hospitalists based on recently published pivotal studies. The expanding evidence base in sepsis includes early goal-directed therapy/clinical endpoints/sepsis bundles, antibiotics and source control, volume resuscitation, ICU considerations (including the use of insulin and corticosteroids), mortality/complications, and the newly recognized condition of "sepsis survivorship".

  7. Office Operative Hysteroscopy - an Update.

    Science.gov (United States)

    Salazar, Christina Alicia; Isaacson, Keith

    2017-08-10

    Hysteroscopy is considered the gold standard for evaluation of intracavitary pathology associated with both pre- and postmenopausal patients with abnormal uterine bleeding as well as part of the evaluation of infertility patients with suspected cavity abnormalities. Office-based operative hysteroscopy allows patients to resume activities immediately and successfully integrates clinical practice into a "see and treat" modality, avoiding the added risks of undergoing anesthesia and the inconvenience of going to the operating room. For 2017, the Center for Medicare and Medical Services has incorporated a substantial increase in the reimbursement for a select number of office-based hysteroscopic procedures. This review provides an update on office hysteroscopy indications, equipment, and procedures as well as reviews management of complications that may arise within an office-based practice. Copyright © 2017. Published by Elsevier Inc.

  8. [Antiphospholipid syndrome diagnosis: an update].

    Science.gov (United States)

    Visseaux, Benoit; Masliah-Planchon, Julien; Fischer, Anne-Marie; Darnige, Luc

    2011-01-01

    The antiphospholipid syndrome (APS) is characterized by arterial and/or venous thrombosis and pregnancy morbidity in association with the persistent presence of autoantibodies called antiphospholipid antibodies (APAs). APAs are a heterogeneous group of circulating autoantibodies that can be detected either by phospholipid-dependent coagulation test for lupus anticoagulant (LA) or ELISA test for anticardiolipin and anti-β2GPI antibodies. In 2006, the revised criteria for the diagnosis of APS introduce the anti-β2GPI antibodies as a new biological criterion and highlight the necessity to increase the interval between two positive APA test from 6 to 12 weeks. However, despite these updated criteria, the diagnosis of APS remains challenging and we proposed here to make an overview of the latest evolution in the diagnosis of this syndrome.

  9. Malnutrition and infection: an update.

    Science.gov (United States)

    Solomons, Noel W

    2007-10-01

    The original Scrimshaw, Taylor and Gordon conceptual framework for the interaction of nutrition and infection has well served the scientific community for almost half a century. At its core is the notion of synergistic (mutually reinforcing) and antagonistic (mutually nullifying) influences of the malnourished state on infectious conditions and vice versa. Research on a series of advancing fronts, however, has allowed the incorporation of both relevant public health issues (parasitosis, emerging infectious diseases, obesity and overweight, etc.) and advancing science (molecular immunology, oxidation biology, multiple micronutrient deficiencies, etc.). The present review is an interpretative update on close to 50 years of demographic and epidemiological evolution in the field of human nutrition and the implications for the interaction in the context of microbiological and immunological developments on the infectious side of the dialectic.

  10. An Update on Radio Supernovae

    Science.gov (United States)

    van Dyk, Schuyler D.; Sramek, Richard A.; Weiler, Kurt W.; Montes, Marcos J.; Panagia, Nino

    The radio emission from supernovae (SNe) is nonthermal synchrotron radiation of high brightness temperature, with a ``turn-on'' delay at longer wavelengths, power-law decline after maximum with index beta, and spectral index alpha asymptotically decreasing with time to a final, optically thin value. Radio supernovae (RSNe) are best described by the Chevalier (1982) ``mini-shell'' model, with modifications by Weiler \\etal\\ (1990). RSNe observations provide a valuable probe of the SN circumstellar environment and constraints on progenitor masses. We present a progress report on a number of recent RSNe, as well as on new behavior from RSNe 1979C and 1980K, and on RSNe as potential distance indicators. In particular, we present updated radio light curves for SN 1993J in M81.

  11. Coronary microvascular dysfunction: an update

    Science.gov (United States)

    Crea, Filippo; Camici, Paolo G.; Bairey Merz, Cathleen Noel

    2014-01-01

    Many patients undergoing coronary angiography because of chest pain syndromes, believed to be indicative of obstructive atherosclerosis of the epicardial coronary arteries, are found to have normal angiograms. In the past two decades, a number of studies have reported that abnormalities in the function and structure of the coronary microcirculation may occur in patients without obstructive atherosclerosis, but with risk factors or with myocardial diseases as well as in patients with obstructive atherosclerosis; furthermore, coronary microvascular dysfunction (CMD) can be iatrogenic. In some instances, CMD represents an epiphenomenon, whereas in others it is an important marker of risk or may even contribute to the pathogenesis of cardiovascular and myocardial diseases, thus becoming a therapeutic target. This review article provides an update on the clinical relevance of CMD in different clinical settings and also the implications for therapy. PMID:24366916

  12. Sprucing up the site - update

    CERN Multimedia

    2009-01-01

    As mentioned in a previous article the Bulletin will be publishing regular short updates following the consolidation work going on around the CERN sites: All internal lighting is being replaced in the office buildings on the Prevessin site. Work has started in building 866 and will move to 864 and 865 later. New energy-efficient lights are being installed, which will reduce electricity consumption by 30 -50%, and in the common areas like corridors the lighting will be switched on by motion sensors. Also in the Prevessin site, the lines in the car parks are being repainted. This will continue in the Meyrin site later. Work has started in Building 30 to completely refurbish the AT Auditorium.

  13. Greece; Report on Observance of Standards and Codes—Fiscal Transparency Module-Update

    OpenAIRE

    International Monetary Fund

    2003-01-01

    This paper presents an update to the Report on the Observance of Standards and Codes (ROSC) on Fiscal Transparency for Greece. Two important steps toward improving fiscal transparency since the last ROSC update were Greece’s subscription to the Special Data Dissemination Standard in November 2002, and participation in the preparation of the data module of the ROSC. Other steps included improving fiscal audits and the evaluation of budget expenditure, and measures in the recent tax reform to...

  14. Update and improvement of the global krypton-85 emission inventory.

    Science.gov (United States)

    Ahlswede, Jochen; Hebel, Simon; Ross, J Ole; Schoetter, Robert; Kalinowski, Martin B

    2013-01-01

    Krypton-85 is mainly produced in nuclear reactors by fission of uranium and plutonium and released during chopping and dissolution of spent fuel rods in nuclear reprocessing facilities. As noble gas it is suited as a passive tracer for evaluation of atmospheric transport models. Furthermore, research is ongoing to assess its quality as an indicator for clandestine reprocessing activities. This paper continues previous efforts to compile a comprehensive historic emission inventory for krypton-85. Reprocessing facilities are the by far largest emitters of krypton-85. Information on sources and calculations used to derive the annual krypton-85 emission is provided for all known reprocessing facilities in the world. In addition, the emission characteristics of two plants, Tokai (Japan) and La Hague (France), are analysed in detail using emission data with high temporal resolution. Other types of krypton-85 sources are power reactors, naval reactors and isotope production facilities. These sources contribute only little or negligible amounts of krypton-85 compared to the large reprocessing facilities. Taking the decay of krypton-85 into account, the global atmospheric inventory is estimated to about 5500 PBq at the end of 2009. The correctness if the inventory has been proven by meteorological simulations and its error is assumed to be in the range of a few percent.

  15. 9x15 Low Speed Wind Tunnel Improvements Update

    Science.gov (United States)

    Stephens, David

    2017-01-01

    The 9- by 15-Foot Low Speed Wind Tunnel (9x15 LSWT) at NASA Glenn Research Center was built in 1969 in the return leg of the 8- by 6-Foot Supersonic Wind Tunnel (8x6 SWT). The 9x15 LSWT was designed for performance testing of VSTOL aircraft models, but with the addition of the current acoustic treatment in 1986 the tunnel been used principally for acoustic and performance testing of aircraft propulsion systems. The present document describes an anticipated acoustic upgrade to be completed in 2018.

  16. Preoperative Chemotherapy, Radiation Improve Survival in Esophageal Cancer (Updated)

    Science.gov (United States)

    Patients with esophageal cancer who received chemotherapy and radiation before surgery survived, on average, nearly twice as long as patients treated with surgery alone, according to results of a randomized clinical trial published May 31, 2012, in NEJM.

  17. Improving Global Multi-target Tracking with Local Updates

    DEFF Research Database (Denmark)

    Milan, Anton; Gade, Rikke; Dick, Anthony;

    2014-01-01

    We propose a scheme to explicitly detect and resolve ambiguous situations in multiple target tracking. During periods of uncertainty, our method applies multiple local single target trackers to hypothesise short term tracks. These tracks are combined with the tracks obtained by a global multi......-target tracker, if they result in a reduction in the global cost function. Since tracking failures typically arise when targets become occluded, we propose a local data association scheme to maintain the target identities in these situations. We demonstrate a reduction of up to 50% in the global cost function...

  18. Up-date of traveling wave tube improvements

    Science.gov (United States)

    Buck, E.

    1978-01-01

    NASA research in the area of traveling wave tube technology is reviewed, with emphasis on the basic physics of guns and collectors and a computer model for the interaction between the electron beam and the RF circuit. The design of a multistage depressed collector, capable of multiplying tube efficiency by a factor of two or more, is presented; one such design has been adopted for commercial traveling wave tube production. A three-dimensional model of electron trajectories toward the collector also receives attention, as does the problem of RF circuit losses.

  19. Updating Recursive XML Views of Relations

    Institute of Scientific and Technical Information of China (English)

    Byron Choi; Gao Cong; Wenfei Fan; Stratis D. Viglas

    2008-01-01

    This paper investigates the view update problem for XML views published from relational data. We consider XML views defined in terms of mappings directed by possibly recursive DTDs compressed into DAGs and stored in relations.We provide new techniques to efficiently support XML view updates specified in terms of Xpath expressions with recursion and complex filters. The interaction between Xpath recursion and DAG compression of XML views makes the analysis of the XML view update problem rather intriguing. Furthermore, many issues are still open even for relational view updates,and need to be explored. In response to these, on the XML side, we revise the notion of side effects and update semantics based on the semantics of XML views, and present efficient algorithms to translate XML updates to relational view updates.On the relational side, we propose a mild condition on SPJ views, and show that under this condition the analysis of deletions on relational views becomes PTIME while the insertion analysis is NP-complete. We develop an efficient algorithm to process relational view deletions, and a heuristic algorithm to handle view insertions. Finally, we present an experimental study to verify the effectiveness of our techniques.

  20. Operational modal analysis by updating autoregressive model

    Science.gov (United States)

    Vu, V. H.; Thomas, M.; Lakis, A. A.; Marcouiller, L.

    2011-04-01

    This paper presents improvements of a multivariable autoregressive (AR) model for applications in operational modal analysis considering simultaneously the temporal response data of multi-channel measurements. The parameters are estimated by using the least squares method via the implementation of the QR factorization. A new noise rate-based factor called the Noise rate Order Factor (NOF) is introduced for use in the effective selection of model order and noise rate estimation. For the selection of structural modes, an orderwise criterion called the Order Modal Assurance Criterion (OMAC) is used, based on the correlation of mode shapes computed from two successive orders. Specifically, the algorithm is updated with respect to model order from a small value to produce a cost-effective computation. Furthermore, the confidence intervals of each natural frequency, damping ratio and mode shapes are also computed and evaluated with respect to model order and noise rate. This method is thus very effective for identifying the modal parameters in case of ambient vibrations dealing with modern output-only modal analysis. Simulations and discussions on a steel plate structure are presented, and the experimental results show good agreement with the finite element analysis.

  1. Kawasaki Disease: A Clinician’s Update

    Directory of Open Access Journals (Sweden)

    Nathan Jamieson

    2013-01-01

    Full Text Available Aims. Kawasaki disease is an acute systemic vasculitis and is the most common cause of acquired heart disease in children in the developed world. This review aims to synthesise recent insights into the disease and provide an update for clinicians on diagnostic and treatment practices. Methods. We conducted a review of the literature exploring epidemiology, aetiology, diagnosis, and management of Kawasaki disease. We searched MEDLINE, Medline In-Process, Embase, Google Scholar, and reference lists of relevant articles. Conclusions. Kawasaki disease is a febrile vasculitis which progresses to coronary artery abnormalities in 25% of untreated patients. The disease is believed to result from a genetically susceptible individual’s exposure to an environmental trigger. Incidence is rising worldwide, and varies widely across countries and within different ethnic groups. Diagnosis is based on the presence of fever in addition to four out of five other clinical criteria, but it is complicated by the quarter of the Kawasaki disease patients with “incomplete” presentation. Treatment with intravenous immunoglobulin within ten days of fever onset improves clinical outcomes and reduces the incidence of coronary artery dilation to less than 5%. Given its severe morbidity and potential mortality, Kawasaki disease should be considered as a potential diagnosis in cases of prolonged paediatric fever.

  2. Update on treatments of diabetic macular edema

    Institute of Scientific and Technical Information of China (English)

    YANG Xiao-lu; LIU Kun; XU Xun

    2009-01-01

    Objective To review the update research progress about the treatment of diabetic macular edema and to give helpful guidelines in the treatment of diabetic macular edema based on available evidence to date.Data sources A literature search of all English articles was performed on the online electronic PubMed database dated 1984 to 2009. The keywords searched included: macular edema, therapy, laser coagulation, intravitreal triamcinolone acetonide, vascular endothelial growth factor inhibitor, protein kinase C inhibitor and Pars plana vitrectomy. After finding relevant articles within these search limits, a manual search was conducted through the references from these articles.Study selection Original articles and critical reviews were reviewed and selected to address the stated purpose.Results To date, demonstrated means to reduce the risk of vision loss from diabetic macular edema include focal/grid laser photocoagulation and improved metabolic control. Emerging pharmacologic therapies (intravitreal triamcinolone acetonide, vascular endothelial growth factor inhibitors and protein kinase C beta-isoform inhibitors) and Pars plana vitrectomy have shown early promise in the treatment of diabetic macular edema.Conclusions As there has been extensive development in multiple treatments of diabetic macular edema, choice of the most suitable treatment for specific patients becomes important. Combination therapy of laser, pharmacological and surgical treatment modalities may offer an alternative to treatment of diabetic macular edema.

  3. African swine fever: an epidemiological update.

    Science.gov (United States)

    Sánchez-Vizcaíno, J M; Mur, L; Martínez-López, B

    2012-03-01

    African swine fever (ASF) is one of the most important swine diseases, mainly because of its significant sanitary and socioeconomic consequences. This review gives an update on the epidemiology of the disease and reviews key issues and strategies to improve control of the disease and promote its eradication. Several characteristics of ASF virus (ASFV) make its control and eradication difficult, including the absence of available vaccines, marked virus resistance in infected material and contaminated animal products, and a complex epidemiology and transmission involving tick reservoir virus interactions. The incidence of ASF has not only increased on the African continent over the last 15 years, so that it now affects West African countries, Mauritius and Madagascar, but it has also reached new areas, such as the Caucasus region in 2007. In fact, the rapid spread of the disease on the European continent and the uncontrolled situation in the Russian Federation places all countries at great risk as a result of intense global trade. The proximity of some affected areas to the European Union (EU) borders (African swine fever -free countries should be aware of the potential risk of ASF incursion and implement risk reduction measures such as trade controls and other sanitary measures. This review will discuss lessons learnt so far about ASF control, current challenges to its control and future studies needed to support global efforts at prevention and control.

  4. MARMOT update for oxide fuel modeling

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yongfeng [Idaho National Lab. (INL), Idaho Falls, ID (United States); Schwen, Daniel [Idaho National Lab. (INL), Idaho Falls, ID (United States); Chakraborty, Pritam [Idaho National Lab. (INL), Idaho Falls, ID (United States); Jiang, Chao [Idaho National Lab. (INL), Idaho Falls, ID (United States); Aagesen, Larry [Idaho National Lab. (INL), Idaho Falls, ID (United States); Ahmed, Karim [Idaho National Lab. (INL), Idaho Falls, ID (United States); Jiang, Wen [Idaho National Lab. (INL), Idaho Falls, ID (United States); Biner, Bulent [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bai, Xianming [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Tonks, Michael [Pennsylvania State Univ., University Park, PA (United States); Millett, Paul [Univ. of Arkansas, Fayetteville, AR (United States)

    2016-09-01

    This report summarizes the lower-length-scale research and development progresses in FY16 at Idaho National Laboratory in developing mechanistic materials models for oxide fuels, in parallel to the development of the MARMOT code which will be summarized in a separate report. This effort is a critical component of the microstructure based fuel performance modeling approach, supported by the Fuels Product Line in the Nuclear Energy Advanced Modeling and Simulation (NEAMS) program. The progresses can be classified into three categories: 1) development of materials models to be used in engineering scale fuel performance modeling regarding the effect of lattice defects on thermal conductivity, 2) development of modeling capabilities for mesoscale fuel behaviors including stage-3 gas release, grain growth, high burn-up structure, fracture and creep, and 3) improved understanding in material science by calculating the anisotropic grain boundary energies in UO$_2$ and obtaining thermodynamic data for solid fission products. Many of these topics are still under active development. They are updated in the report with proper amount of details. For some topics, separate reports are generated in parallel and so stated in the text. The accomplishments have led to better understanding of fuel behaviors and enhance capability of the MOOSE-BISON-MARMOT toolkit.

  5. Dynamic Model Updating Using Virtual Antiresonances

    Directory of Open Access Journals (Sweden)

    Walter D’Ambrogio

    2004-01-01

    Full Text Available This paper considers an extension of the model updating method that minimizes the antiresonance error, besides the natural frequency error. By defining virtual antiresonances, this extension allows the use of previously identified modal data. Virtual antiresonances can be evaluated from a truncated modal expansion, and do not correspond to any physical system. The method is applied to the Finite Element model updating of the GARTEUR benchmark, used within an European project on updating. Results are compared with those previously obtained by estimating actual antiresonances after computing low and high frequency residuals, and with results obtained by using the correlation (MAC between identified and analytical mode shapes.

  6. Research update, existing buildings research, 1989--1991

    Energy Technology Data Exchange (ETDEWEB)

    MacDonald, J.M.; Ternes, M.P.; Mixon, W.R.; Sharp, T.R.; Kolb, J.O.; Wilkes, K.E. [Oak Ridge National Lab., TN (United States); Diamond, R.C. [Lawrence Berkeley Lab., CA (United States); Judkoff, R. [National Renewable Energy Lab., Golden, CO (United States); Mazzucchi, R.P. [Pacific Northwest Lab., Richland, WA (United States)

    1993-02-01

    This Research Update presents the status of the Existing Buildings Research program of the Office of Building Technologies of the US Department of Energy for the period 1989-199 1. This program covers research on energy efficiency improvements for the residential and commercial buildings in this country. ne Existing Buildings Research program has contributed to significant improvements in energy efficiency of existing buildings by development of improvements to retrofit technologies, by coordinating and conducting research studies on the use of energy efficiency technologies (to reduce barriers and increase use), and by continually evaluating changes in technologies that could improve and maintain buildings energy efficiency. If the energy efficiency of the buildings sector in this country is to be dramatically improved over the next 30 years, we must improve the use of energy efficiency technologies. Improved delivery of measures, improved understanding of how buildings actually perform in the field, and methods for improving operations and maintenance of buildings and energy equipment are all examples of ways to improve the deployment (transfer) of technologies. Much has been learned about technology deployment in buildings in the first five years of the program, and our future plans will be directed at continuing the improvements and making a real contribution to the energy efficiency future of the United States.

  7. Research update, existing buildings research, 1989--1991

    Energy Technology Data Exchange (ETDEWEB)

    MacDonald, J.M.; Ternes, M.P.; Mixon, W.R.; Sharp, T.R.; Kolb, J.O.; Wilkes, K.E. (Oak Ridge National Lab., TN (United States)); Diamond, R.C. (Lawrence Berkeley Lab., CA (United States)); Judkoff, R. (National Renewable Energy Lab., Golden, CO (United States)); Mazzucchi, R.P. (Pacific Northwest Lab., Richland, WA (United States))

    1993-02-01

    This Research Update presents the status of the Existing Buildings Research program of the Office of Building Technologies of the US Department of Energy for the period 1989-199 1. This program covers research on energy efficiency improvements for the residential and commercial buildings in this country. ne Existing Buildings Research program has contributed to significant improvements in energy efficiency of existing buildings by development of improvements to retrofit technologies, by coordinating and conducting research studies on the use of energy efficiency technologies (to reduce barriers and increase use), and by continually evaluating changes in technologies that could improve and maintain buildings energy efficiency. If the energy efficiency of the buildings sector in this country is to be dramatically improved over the next 30 years, we must improve the use of energy efficiency technologies. Improved delivery of measures, improved understanding of how buildings actually perform in the field, and methods for improving operations and maintenance of buildings and energy equipment are all examples of ways to improve the deployment (transfer) of technologies. Much has been learned about technology deployment in buildings in the first five years of the program, and our future plans will be directed at continuing the improvements and making a real contribution to the energy efficiency future of the United States.

  8. Epidemiology of Hypertension in Canada: An Update.

    Science.gov (United States)

    Padwal, Raj S; Bienek, Asako; McAlister, Finlay A; Campbell, Norm R C

    2016-05-01

    High blood pressure (BP) is the leading cause of death and disability in the world. The objective of this analysis was to perform a detailed update of the epidemiology of hypertension in Canada. Five population-based data sources were analyzed. We used the Canadian Health Measures Survey to determine the latest directly measured prevalence, awareness, and control estimates (2012-2013); the National Population Health Survey, and Canadian Community Health Survey to assess crude and age-standardized self-reported prevalence (1994-2013); the Canadian Chronic Disease Surveillance System to assess administrative data-ascertained prevalence and mortality trends (1998-2010); and Intercontinental Medical Statistics Health data to examine antihypertensive drug-prescribing trends and costs (2007-2014). In 2012-2013, the prevalence of hypertension (defined as drug treatment for high BP or BP ≥ 140/90 mm Hg) in Canadian adults was 22.6%, and the proportion of disease controlled was 68.1%. In Canadians with diabetes, the prevalence (defined as drug treatment or BP ≥ 130/80 mm Hg) was 67.1%, and 60.1% of cases were controlled. Self-reported hypertension prevalence has increased by approximately 2-fold over nearly 2 decades. Age-standardized mortality rates are falling in hypertensive Canadians (from 9.4 to 7.9 deaths per 1000 individuals), but to a lesser extent than in nonhypertensive individuals. Total antihypertensive drug prescription volume has increased steadily since 2007 amid falling drug costs. Hypertension prevalence in Canada continues to rise. Increased use of antihypertensive drugs and improvements in control are apparent. Coordinated efforts to further improve the treatment and control of hypertension in Canada are needed. Copyright © 2016 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

  9. Updating neutrino magnetic moment constraints

    CERN Document Server

    Canas, B C; Parada, A; Tortola, M; Valle, J W F

    2015-01-01

    In this paper we provide an updated analysis of the neutrino magnetic moments (NMMs), discussing both the constraints on the magnitudes of the three transition moments Lambda_i as well as the role of the CP violating phases present both in the mixing matrix and in the NMM matrix. The scattering of solar neutrinos off electrons in Borexino provides the most stringent restrictions, due to its robust statistics and the low energies observed, below 1 MeV. Our new limit on the effective neutrino magnetic moment which follows from the most recent Borexino data is 3.1 x 10^-11 mu_B at 90% C.L. This corresponds to the individual transition magnetic moment constraints: |Lambda_1| < 5.6 x10^-11 mu_B, |Lambda_2| < 4.0 x 10^-11 mu_B, and |Lambda_3| < 3.1 x 10^-11 mu_B (90% C.L.), irrespective of any complex phase. Indeed, the incoherent admixture of neutrino mass eigenstates present in the solar flux makes Borexino insensitive to the Majorana phases present in the NMM matrix. For this reason we also provide a gl...

  10. Stuttering: Clinical and research update.

    Science.gov (United States)

    Perez, Hector R; Stoeckle, James H

    2016-06-01

    To provide an update on the epidemiology, genetics, pathophysiology, diagnosis, and treatment of developmental stuttering. The MEDLINE and Cochrane databases were searched for past and recent studies on the epidemiology, genetics, pathophysiology, diagnosis, and treatment of developmental stuttering. Most recommendations are based on small studies, limited-quality evidence, or consensus. Stuttering is a speech disorder, common in persons of all ages, that affects normal fluency and time patterning of speech. Stuttering has been associated with differences in brain anatomy, functioning, and dopamine regulation thought to be due to genetic causes. Attention to making a correct diagnosis or referral in children is important because there is growing consensus that early intervention with speech therapy for children who stutter is critical. For adults, stuttering can be associated with substantial psychosocial morbidity including social anxiety and low quality of life. Pharmacologic treatment has received attention in recent years, but clinical evidence is limited. The mainstay of treatment for children and adults remains speech therapy. A growing body of research has attempted to uncover the pathophysiology of stuttering. Referral for speech therapy remains the best option for children and adults. Copyright© the College of Family Physicians of Canada.

  11. IDSA releases updated coccidioidomycosis guidelines

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2016-09-01

    Full Text Available No abstract available. Article truncated at 150 words. The Infectious Diseases Society of America (IDSA has released updated Guidelines for the Treatment of Coccidioidomycosis, also known as cocci or Valley Fever (1. Coccidioidomycosis is a fungal infection endemic to the southwestern United States and a common cause of pneumonia and pulmonary nodules in this area. However, the infection can disseminate systemically especially in immunocompromised hosts and certain ethnic populations resulting in a variety of pulmonary and extrapulmonary complications. In addition to recommendations for these complications, the new guidelines address management of special at-risk populations, preemptive management strategies in at-risk populations and after unintentional laboratory exposure. The guidelines also suggest shorter courses of antibiotics for hospitalized patients and more ambulatory treatment for most individuals who have contracted Valley Fever. The panel was led by John N. Galgiani, MD, director of the Valley Fever Center for Excellence at the University of Arizona Health Sciences. Galgiani led a panel of 16 ...

  12. Update of the European Landslide Susceptibility Map (ELSUS Version 2)

    Science.gov (United States)

    Wilde, Martina; Günther, Andreas; Malet, Jean-Philippe; Reichenbach, Paola; Hervás, Javier

    2015-04-01

    We present an update of the initial version of the European Landslide Susceptibility Map (ELSUS Version 1) that was released in 2012 through the EU Joint Research Centre (JRC) European Soil Data Centre (ESDAC). The susceptibility evaluation methodology employed for the updated map ELSUS Version 2 presented in this paper is identical to the previous approach, and comprises the differentiation of the analyzed European area into seven climate-physiographical model zones, the use of a reduced set of spatial susceptibility predictors (shallow subsurface lithology, slope angle, and land cover), and model zone-specific heuristic spatial multicriteria evaluations (SMCE) for susceptibility mapping. The most important improvement for ELSUS version 2 is the replacement of the original "lithology" data set consisting of soil parent material information derived from the European Soil Database (ESDB) by new information derived from the digital version of the International Hydrogeological Map of Europe at scale 1 : 1.5 Million (IHME 1500). IHME lithology describes both consolidated and unconsolidated shallow geological materials over Europe and can be shown to have a higher significance for landslide susceptibility evaluation than the soil parent material derived from ESDB. Other improvements consist in the change of the mapping unit from 1 km to 200 m grid size and the incorporation of terrains not covered by ELSUS version 1 (e.g., Iceland, the Faroers, the Shetlands, and Cyprus). Additionally, the new ELSUS version 2 was calibrated and validated with an updated pan-European landslide inventory now containing more than 155,000 landslides (30% more than used for ELSUS version 1). The enhanced and updated landslide inventory and the higher quality of the "lithology" data enabled us to establish more consistent SMCE-schemes for the individual model zones. The enhancements of ELSUS Version 2 result in an overall increase of the predictive power of the map for about 10%, as indicated

  13. Self-Position Update For Geographic Routing For Mobile Ad Hoc Networks

    Directory of Open Access Journals (Sweden)

    G.PRAVEEN

    2013-06-01

    Full Text Available In geographic routing nodes will periodic broadcasting the beacon packet to their neighboring nodes at a equal interval of time that beacon packet contain the nodes present geographic location, but in this process it will increase the update cost and performance of the router will be also will be low. To eliminate this problem we propose this Self-Position Update. SPU works on two principles: (i nodes whose movements are harder to predict update their positions more frequently (and vice versa, (ii nodes which are static and closer to the forwarded path update their position more frequently (and vice versa. Our theoretical analysis, which is validated by NS2 simulations of a well known geographic routing protocol, (DSR Protocol, shows that SPU can significantly reduce the update cost and improve the routing performance in terms of packet delivery ratio and average end-to-end delay in comparison with periodic beaconing and other recently proposed updating schemes. The benefits of SPU are further confirmed by undertaking evaluations in realistic network scenarios, which account for localization error, realistic radio propagation and sparse network.

  14. Flow Forecasting using Deterministic Updating of Water Levels in Distributed Hydrodynamic Urban Drainage Models

    Directory of Open Access Journals (Sweden)

    Lisbet Sneftrup Hansen

    2014-07-01

    Full Text Available There is a growing requirement to generate more precise model simulations and forecasts of flows in urban drainage systems in both offline and online situations. Data assimilation tools are hence needed to make it possible to include system measurements in distributed, physically-based urban drainage models and reduce a number of unavoidable discrepancies between the model and reality. The latter can be achieved partly by inserting measured water levels from the sewer system into the model. This article describes how deterministic updating of model states in this manner affects a simulation, and then evaluates and documents the performance of this particular updating procedure for flow forecasting. A hypothetical case study and synthetic observations are used to illustrate how the Update method works and affects downstream nodes. A real case study in a 544 ha urban catchment furthermore shows that it is possible to improve the 20-min forecast of water levels in an updated node and the three-hour forecast of flow through a downstream node, compared to simulations without updating. Deterministic water level updating produces better forecasts when implemented in large networks with slow flow dynamics and with measurements from upstream basins that contribute significantly to the flow at the forecast location.

  15. Labor law update--Part 1.

    Science.gov (United States)

    Fiesta, J

    1997-01-01

    To ensure proper actions when making managerial decisions, nurses must be aware of labor laws and the policies that apply to them. Part 1 of "Labor Law Update" discusses public policy considerations and gender, racial and pregnancy discrimination.

  16. Model Updating Nonlinear System Identification Toolbox Project

    Data.gov (United States)

    National Aeronautics and Space Administration — ZONA Technology proposes to develop an enhanced model updating nonlinear system identification (MUNSID) methodology by adopting the flight data with state-of-the-art...

  17. CDC Updates Spending Plans to Combat Zika

    Science.gov (United States)

    ... 161541.html CDC Updates Spending Plans to Combat Zika Some goals: prepare states for future outbreaks, and ... dollars to prepare states and cities for future Zika virus outbreaks, and to track the effects of ...

  18. Rapid Update Cycle (RUC) [13 km

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Rapid Update Cycle (RUC) weather forecast model was developed by the National Centers for Environmental Prediction (NCEP). On May 1, 2012, the RUC was replaced...

  19. Rapid Update Cycle (RUC) [20 km

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Rapid Update Cycle (RUC) weather forecast model was developed by the National Centers for Environmental Prediction (NCEP). On May 1, 2012, the RUC was replaced...

  20. Ecological Subsections for Northern Alaska, 2012 update

    Data.gov (United States)

    Arctic Landscape Conservation Cooperative — This data set represents an updated Ecological Subsection Map for Northern Alaska. This 2012 revision focused on completing the incompletely mapped portion of the...

  1. Earth Observing System Covariance Realism Updates

    Science.gov (United States)

    Ojeda Romero, Juan A.; Miguel, Fred

    2017-01-01

    This presentation will be given at the International Earth Science Constellation Mission Operations Working Group meetings June 13-15, 2017 to discuss the Earth Observing System Covariance Realism updates.

  2. Clinical update on nursing home medicine: 2013.

    Science.gov (United States)

    Messinger-Rapport, Barbara J; Gammack, Julie K; Thomas, David R; Morley, John E

    2013-12-01

    This is the seventh article in the series of Clinical Updates on Nursing Home Care. The topics covered are antiresorptive drugs, hip fracture, hypertension, orthostatic hypotension, depression, undernutrition, anorexia, cachexia, sarcopenia, exercise, pain, and behavioral and psychological symptoms of dementia.

  3. 1990 Kansas Land Cover Patterns Update

    Data.gov (United States)

    Kansas Data Access and Support Center — In 2008, an update of the 1990 Kansas Land Cover Patterns (KLCP) database was undertaken. The 1990 KLCP database depicts 10 general land cover classes for the State...

  4. Bird deterrent and dispersal systems: Research update

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report is a research update on bird deterrent and dispersal systems by the Petroleum Association for Conservation of the Canadian Environment. The purpose of...

  5. Breast Cancer and Estrogen-Alone Update

    Science.gov (United States)

    ... Issues Research News From NIH Breast Cancer and Estrogen-Alone Update Past Issues / Summer 2006 Table of ... version of this page please turn Javascript on. Estrogen-alone hormone therapy does not increase the risk ...

  6. 77 FR 33980 - Proposed FOIA Fee Schedule Update

    Science.gov (United States)

    2012-06-08

    ... NUCLEAR FACILITIES SAFETY BOARD 10 CFR Part 1703 Proposed FOIA Fee Schedule Update AGENCY: Defense Nuclear... the SUPPLEMENTARY INFORMATION to the Board's proposed FOIA Fee Schedule Update published in the... update the FOIA Fee Schedule once every 12 months. Previous Fee Schedule Updates were published in...

  7. Working Memory Updating as a Predictor of Academic Attainment

    Science.gov (United States)

    Lechuga, M. Teresa; Pelegrina, Santiago; Pelaez, Jose L.; Martin-Puga, M. Eva; Justicia, M. Jose

    2016-01-01

    There is growing evidence supporting the importance of executive functions, and specifically working memory updating (WMU), for children's academic achievement. This study aimed to assess the specific contribution of updating to the prediction of academic performance. Two updating tasks, which included different updating components, were…

  8. Environmental Regulatory Update Table, December 1991

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1992-01-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  9. Environmental Regulatory Update Table, December 1989

    Energy Technology Data Exchange (ETDEWEB)

    Houlbert, L.M.; Langston, M.E. (Tennessee Univ., Knoxville, TN (USA)); Nikbakht, A.; Salk, M.S. (Oak Ridge National Lab., TN (USA))

    1990-01-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  10. Environmental Regulatory Update Table, November 1991

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-12-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  11. Environmental Regulatory Update Table, August 1991

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.M., Hawkins, G.T.; Salk, M.S.

    1991-09-01

    This Environmental Regulatory Update Table (August 1991) provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  12. Environmental Regulatory Update Table, September 1991

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-10-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  13. Environmental Regulatory Update Table, October 1991

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-11-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  14. Environmental Regulatory Update Table, April 1989

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.; Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1989-05-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  15. Military Specification Updates & Deicing Working Group Initiatives

    Science.gov (United States)

    2011-08-18

    Air Force Petroleum Agency I n t e g r i t y - S e r v i c e - E x c e l l e n c e Military Specification Updates & Deicing Working Group...00-2011 4. TITLE AND SUBTITLE Military Specification Updates & Deicing Working Group Initiatives 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c...Corrosion Runway Deicing Fluid Partnership with Battelle Memorial Institute (lead agency), AFRL/ ASC, Army (CRREL), Navy (NAVAIR), Octagon, AMIL

  16. Environmental Regulatory Update Table, April 1989

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.; Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1989-05-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  17. Environmental regulatory update table, March 1989

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.; Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1989-04-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  18. Environmental Regulatory Update Table, November 1991

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-12-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  19. An updated geospatial liquefaction model for global application

    Science.gov (United States)

    Zhu, Jing; Baise, Laurie G.; Thompson, Eric

    2017-01-01

    We present an updated geospatial approach to estimation of earthquake-induced liquefaction from globally available geospatial proxies. Our previous iteration of the geospatial liquefaction model was based on mapped liquefaction surface effects from four earthquakes in Christchurch, New Zealand, and Kobe, Japan, paired with geospatial explanatory variables including slope-derived VS30, compound topographic index, and magnitude-adjusted peak ground acceleration from ShakeMap. The updated geospatial liquefaction model presented herein improves the performance and the generality of the model. The updates include (1) expanding the liquefaction database to 27 earthquake events across 6 countries, (2) addressing the sampling of nonliquefaction for incomplete liquefaction inventories, (3) testing interaction effects between explanatory variables, and (4) overall improving model performance. While we test 14 geospatial proxies for soil density and soil saturation, the most promising geospatial parameters are slope-derived VS30, modeled water table depth, distance to coast, distance to river, distance to closest water body, and precipitation. We found that peak ground velocity (PGV) performs better than peak ground acceleration (PGA) as the shaking intensity parameter. We present two models which offer improved performance over prior models. We evaluate model performance using the area under the curve under the Receiver Operating Characteristic (ROC) curve (AUC) and the Brier score. The best-performing model in a coastal setting uses distance to coast but is problematic for regions away from the coast. The second best model, using PGV, VS30, water table depth, distance to closest water body, and precipitation, performs better in noncoastal regions and thus is the model we recommend for global implementation.

  20. Nootropic herbs (Medhya Rasayana) in Ayurveda: An update.

    Science.gov (United States)

    Kulkarni, Reena; Girish, K J; Kumar, Abhimanyu

    2012-07-01

    Cognitive deficits that present with many of neuropsychiatric conditions and/or alone as developmental deficit demand use of nootropics to boost cognitive abilities. Recently there is a tremendous urge to explore medicinal plants globally for improving cognitive function owing to their less adverse effects. Ayurveda provides a list of herbs known for nootropic activity as well as their multi-dimensional utility in various conditions. Present paper is a review to update knowledge on pharmacological properties, major chemical constituents, therapeutic actions, preclinical studies, safety and possible mode of action of the selected herbs from ayurvedic pharmacopoeia. Concurrently, it opens up for further research and standardization on nootropic herbs.

  1. Nootropic herbs (Medhya Rasayana in Ayurveda: An update

    Directory of Open Access Journals (Sweden)

    Reena Kulkarni

    2012-01-01

    Full Text Available Cognitive deficits that present with many of neuropsychiatric conditions and/or alone as developmental deficit demand use of nootropics to boost cognitive abilities. Recently there is a tremendous urge to explore medicinal plants globally for improving cognitive function owing to their less adverse effects. Ayurveda provides a list of herbs known for nootropic activity as well as their multi-dimensional utility in various conditions. Present paper is a review to update knowledge on pharmacological properties, major chemical constituents, therapeutic actions, preclinical studies, safety and possible mode of action of the selected herbs from ayurvedic pharmacopoeia. Concurrently, it opens up for further research and standardization on nootropic herbs

  2. Active Magnetic Bearing Rotor Model Updating Using Resonance and MAC Error

    Directory of Open Access Journals (Sweden)

    Yuanping Xu

    2015-01-01

    Full Text Available Modern control techniques can improve the performance and robustness of a rotor active magnetic bearing (AMB system. Since those control methods usually rely on system models, it is important to obtain a precise rotor AMB analytical model. However, the interference fits and shrink effects of rotor AMB cause inaccuracy to the final system model. In this paper, an experiment based model updating method is proposed to improve the accuracy of the finite element (FE model used in a rotor AMB system. Modelling error is minimized by applying a numerical optimization Nelder-Mead simplex algorithm to properly adjust FE model parameters. Both the error resonance frequencies and modal assurance criterion (MAC values are minimized simultaneously to account for the rotor natural frequencies as well as for the mode shapes. Verification of the updated rotor model is performed by comparing the experimental and analytical frequency response. The close agreements demonstrate the effectiveness of the proposed model updating methodology.

  3. Quantifying Update Effects in Citizen-Oriented Software

    Directory of Open Access Journals (Sweden)

    Ion Ivan

    2009-02-01

    Full Text Available Defining citizen-oriented software. Detailing technical issues regarding update process in this kind of software. Presenting different effects triggered by types of update. Building model for update costs estimation, including producer-side and consumer-side effects. Analyzing model applicability on INVMAT – large scale matrix inversion software. Proposing a model for update effects estimation. Specifying ways for softening effects of inaccurate updates.

  4. The role of anti-resonance frequencies from operational modal analysis in finite element model updating

    Science.gov (United States)

    Hanson, D.; Waters, T. P.; Thompson, D. J.; Randall, R. B.; Ford, R. A. J.

    2007-01-01

    anti-resonances. It is found that the addition of anti-resonance information improves the updating performance for some combinations of parameter values, but does not improve the update in significant other regions. The simulated results are verified using resonance and anti-resonance frequencies measured on a steel beam test rig. The investigation is extended to include the updating of parameters of a petrol generator set. It is found that the contribution of the anti-resonances to the model update is heavily dependent on the geometry of the model and the choice of variables to be updated, suggesting that, for some models, the pursuit of anti-resonance information through expensive operational modal analysis may be inappropriate.

  5. Dissociating Working Memory Updating and Automatic Updating: The Reference-Back Paradigm

    Science.gov (United States)

    Rac-Lubashevsky, Rachel; Kessler, Yoav

    2016-01-01

    Working memory (WM) updating is a controlled process through which relevant information in the environment is selected to enter the gate to WM and substitute its contents. We suggest that there is also an automatic form of updating, which influences performance in many tasks and is primarily manifested in reaction time sequential effects. The goal…

  6. Macroscopic Quantum Resonators (MAQRO): 2015 update

    Energy Technology Data Exchange (ETDEWEB)

    Kaltenbaek, Rainer [University of Vienna, Vienna Center for Quantum Science and Technology, Vienna (Austria); Aspelmeyer, Markus; Kiesel, Nikolai [University of Vienna, Vienna Center for Quantum Science and Technology, Vienna (Austria); Barker, Peter F.; Bose, Sougato [University College London, Department of Physics and Astronomy, London (United Kingdom); Bassi, Angelo [University of Trieste, Department of Physics, Trieste (Italy); INFN - Trieste Section, Trieste (Italy); Bateman, James [University of Swansea, Department of Physics, College of Science, Swansea (United Kingdom); Bongs, Kai; Cruise, Adrian Michael [University of Birmingham, School of Physics and Astronomy, Birmingham (United Kingdom); Braxmaier, Claus [University of Bremen, Center of Applied Space Technology and Micro Gravity (ZARM), Bremen (Germany); Institute of Space Systems, German Aerospace Center (DLR), Bremen (Germany); Brukner, Caslav [University of Vienna, Vienna Center for Quantum Science and Technology, Vienna (Austria); Austrian Academy of Sciences, Institute of Quantum Optics and Quantum Information (IQOQI), Vienna (Austria); Christophe, Bruno; Rodrigues, Manuel [The French Aerospace Lab, ONERA, Chatillon (France); Chwalla, Michael; Johann, Ulrich [Airbus Defence and Space GmbH, Immenstaad (Germany); Cohadon, Pierre-Francois; Heidmann, Antoine; Lambrecht, Astrid; Reynaud, Serge [ENS-PSL Research University, Laboratoire Kastler Brossel, UPMC-Sorbonne Universites, CNRS, College de France, Paris (France); Curceanu, Catalina [Laboratori Nazionali di Frascati dell' INFN, Frascati (Italy); Dholakia, Kishan; Mazilu, Michael [University of St. Andrews, School of Physics and Astronomy, St. Andrews (United Kingdom); Diosi, Lajos [Wigner Research Center for Physics, P.O. Box 49, Budapest (Hungary); Doeringshoff, Klaus; Peters, Achim [Humboldt-Universitaet zu Berlin, Institut fuer Physik, Berlin (Germany); Ertmer, Wolfgang; Rasel, Ernst M. [Leibniz Universitaet Hannover, Institut fuer Quantenoptik, Hannover (Germany); Gieseler, Jan; Novotny, Lukas; Rondin, Loic [ETH Zuerich, Photonics Laboratory, Zuerich (Switzerland); Guerlebeck, Norman; Herrmann, Sven; Laemmerzahl, Claus [University of Bremen, Center of Applied Space Technology and Micro Gravity (ZARM), Bremen (Germany); Hechenblaikner, Gerald [Airbus Defence and Space GmbH, Immenstaad (Germany); European Southern Observatory (ESO), Garching bei Muenchen (Germany); Hossenfelder, Sabine [KTH Royal Institute of Technology and Stockholm University, Nordita, Stockholm (Sweden); Kim, Myungshik [Imperial College London, QOLS, Blackett Laboratory, London (United Kingdom); Milburn, Gerard J. [University of Queensland, ARC Centre for Engineered Quantum Systems, Brisbane (Australia); Mueller, Holger [University of California, Department of Physics, Berkeley, CA (United States); Paternostro, Mauro [Queen' s University, Centre for Theoretical Atomic, Molecular and Optical Physics, School of Mathematics and Physics, Belfast (United Kingdom); Pikovski, Igor [Harvard-Smithsonian Center for Astrophysics, ITAMP, Cambridge, MA (United States); Pilan Zanoni, Andre [Airbus Defence and Space GmbH, Immenstaad (Germany); CERN - European Organization for Nuclear Research, EN-STI-TCD, Geneva (Switzerland); Riedel, Charles Jess [Perimeter Institute for Theoretical Physics, Waterloo, ON (Canada); Roura, Albert [Universitaet Ulm, Institut fuer Quantenphysik, Ulm (Germany); Schleich, Wolfgang P. [Universitaet Ulm, Institut fuer Quantenphysik, Ulm (Germany); Texas A and M University Institute for Advanced Study (TIAS), Institute for Quantum Science and Engineering (IQSE), and Department of Physics and Astronomy, College Station, TX (United States); Schmiedmayer, Joerg [Vienna University of Technology, Vienna Center for Quantum Science and Technology, Institute of Atomic and Subatomic Physics, Vienna (Austria); Schuldt, Thilo [Institute of Space Systems, German Aerospace Center (DLR), Bremen (Germany); Schwab, Keith C. [California Institute of Technology, Applied Physics, Pasadena, CA (United States)

    2016-12-15

    Do the laws of quantum physics still hold for macroscopic objects - this is at the heart of Schroedinger's cat paradox - or do gravitation or yet unknown effects set a limit for massive particles? What is the fundamental relation between quantum physics and gravity? Ground-based experiments addressing these questions may soon face limitations due to limited free-fall times and the quality of vacuum and microgravity. The proposed mission Macroscopic Quantum Resonators (MAQRO) may overcome these limitations and allow addressing such fundamental questions. MAQRO harnesses recent developments in quantum optomechanics, high-mass matter-wave interferometry as well as state-of-the-art space technology to push macroscopic quantum experiments towards their ultimate performance limits and to open new horizons for applying quantum technology in space. The main scientific goal is to probe the vastly unexplored 'quantum-classical' transition for increasingly massive objects, testing the predictions of quantum theory for objects in a size and mass regime unachievable in ground-based experiments. The hardware will largely be based on available space technology. Here, we present the MAQRO proposal submitted in response to the 4th Cosmic Vision call for a medium-sized mission (M4) in 2014 of the European Space Agency (ESA) with a possible launch in 2025, and we review the progress with respect to the original MAQRO proposal for the 3rd Cosmic Vision call for a medium-sized mission (M3) in 2010. In particular, the updated proposal overcomes several critical issues of the original proposal by relying on established experimental techniques from high-mass matter-wave interferometry and by introducing novel ideas for particle loading and manipulation. Moreover, the mission design was improved to better fulfill the stringent environmental requirements for macroscopic quantum experiments. (orig.)

  7. An Updated 2017 Astrometric Solution for Betelgeuse

    Science.gov (United States)

    Harper, G. M.; Brown, A.; Guinan, E. F.; O'Gorman, E.; Richards, A. M. S.; Kervella, P.; Decin, L.

    2017-07-01

    We provide an update for the astrometric solution for the Type II supernova progenitor Betelgeuse using the revised Hipparcos Intermediate Astrometric Data (HIAD) of van Leeuwen, combined with existing VLA and new e-MERLIN and ALMA positions. The 2007 Hipparcos refined abscissa measurements required the addition of so-called Cosmic Noise of 2.4 mas to find an acceptable 5-parameter stochastic solution. We find that a measure of radio Cosmic Noise should also be included for the radio positions because surface inhomogeneities exist at a level significant enough to introduce additional intensity centroid uncertainty. Combining the 2007 HIAD with the proper motions based solely on the radio positions leads to a parallax of π =5.27+/- 0.78 mas ({190}-25+33 pc), smaller than the Hipparcos 2007 value of 6.56 ± 0.83 mas ({152}-17+22 pc). Furthermore, combining the VLA and new e-MERLIN and ALMA radio positions with the 2007 HIAD, and including radio Cosmic Noise of 2.4 mas, leads to a nominal parallax solution of 4.51 ± 0.80 mas ({222}-34+48 pc), which, while only 0.7σ different from the 2008 solution of Harper et al., is 2.6σ different from the solution of van Leeuwen. An accurate and precise parallax for Betelgeuse is always going to be difficult to obtain because it is small compared to the stellar angular diameter (θ =44 mas). We outline an observing strategy utilizing future mm and sub-mm high-spatial resolution interferometry that must be used if substantial improvements in the precision and accuracy of the parallax and distance are to be achieved.

  8. 2015 Update on Parkinson disease.

    Science.gov (United States)

    Fernandez, Hubert H

    2015-09-01

    Parkinson disease is still diagnosed by clinical signs, and its most effective treatment is still levodopa. However, an improved understanding of the disease is leading to new diagnostic tools and treatments.

  9. Prostate imaging. An update; Bildgebung der Prostata. Ein Update

    Energy Technology Data Exchange (ETDEWEB)

    Franiel, T.; Teichgraeber, U. [University Hospital Jena (Germany). Dept. of Diagnostic and Interventional Radiology; Asbach, P.; Hamm, B. [University Medicine Berlin (Germany). Dept. of Radiology; Foller, S. [University Hospital Jena (Germany). Dept. of Urology

    2015-09-15

    New technical and clinical developments of sonography and magnetic resonance imaging include improved detection, localization and staging as well as active surveillance of prostate cancer. Multiparametric MRI can best answer these typical clinical questions. However, ultrasound elastography seems to be suitable for the detection of significant prostate cancer as well. The structured reporting system for multiparametric MRI of the prostate according to PI-RADS Version 1 led to improved and reproducible diagnosis of prostate cancer. The new PI-RADS Version 2 aims to minimize the limitations of Version 1 and make PI-RADS standardization more globally acceptable.

  10. Updated NGNP Fuel Acquisition Strategy

    Energy Technology Data Exchange (ETDEWEB)

    David Petti; Tim Abram; Richard Hobbins; Jim Kendall

    2010-12-01

    A Next Generation Nuclear Plant (NGNP) fuel acquisition strategy was first established in 2007. In that report, a detailed technical assessment of potential fuel vendors for the first core of NGNP was conducted by an independent group of international experts based on input from the three major reactor vendor teams. Part of the assessment included an evaluation of the credibility of each option, along with a cost and schedule to implement each strategy compared with the schedule and throughput needs of the NGNP project. While credible options were identified based on the conditions in place at the time, many changes in the assumptions underlying the strategy and in externalities that have occurred in the interim requiring that the options be re-evaluated. This document presents an update to that strategy based on current capabilities for fuel fabrication as well as fuel performance and qualification testing worldwide. In light of the recent Pebble Bed Modular Reactor (PBMR) project closure, the Advanced Gas Reactor (AGR) fuel development and qualification program needs to support both pebble and prismatic options under the NGNP project. A number of assumptions were established that formed a context for the evaluation. Of these, the most important are: • Based on logistics associated with the on-going engineering design activities, vendor teams would start preliminary design in October 2012 and complete in May 2014. A decision on reactor type will be made following preliminary design, with the decision process assumed to be completed in January 2015. Thus, no fuel decision (pebble or prismatic) will be made in the near term. • Activities necessary for both pebble and prismatic fuel qualification will be conducted in parallel until a fuel form selection is made. As such, process development, fuel fabrication, irradiation, and testing for pebble and prismatic options should not negatively influence each other during the period prior to a decision on reactor type

  11. Valence-Dependent Belief Updating: Computational Validation.

    Science.gov (United States)

    Kuzmanovic, Bojana; Rigoux, Lionel

    2017-01-01

    People tend to update beliefs about their future outcomes in a valence-dependent way: they are likely to incorporate good news and to neglect bad news. However, belief formation is a complex process which depends not only on motivational factors such as the desire for favorable conclusions, but also on multiple cognitive variables such as prior beliefs, knowledge about personal vulnerabilities and resources, and the size of the probabilities and estimation errors. Thus, we applied computational modeling in order to test for valence-induced biases in updating while formally controlling for relevant cognitive factors. We compared biased and unbiased Bayesian models of belief updating, and specified alternative models based on reinforcement learning. The experiment consisted of 80 trials with 80 different adverse future life events. In each trial, participants estimated the base rate of one of these events and estimated their own risk of experiencing the event before and after being confronted with the actual base rate. Belief updates corresponded to the difference between the two self-risk estimates. Valence-dependent updating was assessed by comparing trials with good news (better-than-expected base rates) with trials with bad news (worse-than-expected base rates). After receiving bad relative to good news, participants' updates were smaller and deviated more strongly from rational Bayesian predictions, indicating a valence-induced bias. Model comparison revealed that the biased (i.e., optimistic) Bayesian model of belief updating better accounted for data than the unbiased (i.e., rational) Bayesian model, confirming that the valence of the new information influenced the amount of updating. Moreover, alternative computational modeling based on reinforcement learning demonstrated higher learning rates for good than for bad news, as well as a moderating role of personal knowledge. Finally, in this specific experimental context, the approach based on reinforcement

  12. Valence-Dependent Belief Updating: Computational Validation

    Directory of Open Access Journals (Sweden)

    Bojana Kuzmanovic

    2017-06-01

    Full Text Available People tend to update beliefs about their future outcomes in a valence-dependent way: they are likely to incorporate good news and to neglect bad news. However, belief formation is a complex process which depends not only on motivational factors such as the desire for favorable conclusions, but also on multiple cognitive variables such as prior beliefs, knowledge about personal vulnerabilities and resources, and the size of the probabilities and estimation errors. Thus, we applied computational modeling in order to test for valence-induced biases in updating while formally controlling for relevant cognitive factors. We compared biased and unbiased Bayesian models of belief updating, and specified alternative models based on reinforcement learning. The experiment consisted of 80 trials with 80 different adverse future life events. In each trial, participants estimated the base rate of one of these events and estimated their own risk of experiencing the event before and after being confronted with the actual base rate. Belief updates corresponded to the difference between the two self-risk estimates. Valence-dependent updating was assessed by comparing trials with good news (better-than-expected base rates with trials with bad news (worse-than-expected base rates. After receiving bad relative to good news, participants' updates were smaller and deviated more strongly from rational Bayesian predictions, indicating a valence-induced bias. Model comparison revealed that the biased (i.e., optimistic Bayesian model of belief updating better accounted for data than the unbiased (i.e., rational Bayesian model, confirming that the valence of the new information influenced the amount of updating. Moreover, alternative computational modeling based on reinforcement learning demonstrated higher learning rates for good than for bad news, as well as a moderating role of personal knowledge. Finally, in this specific experimental context, the approach based on

  13. Lindamood Phoneme Sequencing® (LiPS®). What Works Clearinghouse Intervention Report. Updated November 2015

    Science.gov (United States)

    What Works Clearinghouse, 2015

    2015-01-01

    The "Lindamood Phonemic Sequencing"® program is designed to improve reading and spelling skills by teaching students the skills needed to decode and encode words and to identify individual sounds and blends in words. The WWC has updated its 2008 review of "Lindamood Phonemic Sequencing"® to include 16 new studies, two of which…

  14. Update on Research and Leadership. Vol. 20, No. 2. Spring 2009

    Science.gov (United States)

    Bragg, Debra D., Ed.: Khan, Sadya, Ed.; Kirby, Catherine, Ed.

    2009-01-01

    Increasing rates of remediation in college and the alignment gap between secondary and postsecondary education call for further study of policies and practices to improve college and career readiness. This issue of Update on Research and Leadership features nine articles that highlight current research and practice related to college readiness and…

  15. Near- and far-transfer effects of working memory updating training in elderly adults

    NARCIS (Netherlands)

    Xin, Z.; Lai, Z.R.; Fu, L.; Maes, J.H.R.

    2014-01-01

    Age-related declines in working memory, especially with regard to updating ability, affect many high-level aspects of cognition in elderly adults. Recent studies have demonstrated that training might improve working memory. We investigated the effects of 20days of adaptive training of working memory

  16. 2011 Residential Energy Efficiency Technical Update Meeting Summary Report: Denver, Colorado - August 9-11, 2011

    Energy Technology Data Exchange (ETDEWEB)

    2011-11-01

    This report provides an overview of the U.S. Department of Energy Building America program's Summer 2011 Residential Energy Efficiency Technical Update Meeting. This meeting was held on August 9-11, 2011, in Denver, Colorado, and brought together more than 290 professionals representing organizations with a vested interest in energy efficiency improvements in residential buildings.

  17. Geant4 electromagnetic physics updates for space radiation effects simulation

    Science.gov (United States)

    Ivantchenko, Anton; Nieminen, Petteri; Incerti, Sebastien; Santin, Giovanni; Ivantchenko, Vladimir; Grichine, Vladimir; Allison, John; Karamitos, Mathiew

    The Geant4 toolkit is used in many applications including space science studies. The new Geant4 version 10.0 released in December 2013 includes a major revision of the toolkit and offers multi-threaded mode for event level parallelism. At the same time, Geant4 electromagnetic and hadronic physics sub-libraries have been significantly updated. In order to validate the new and updated models Geant4 verification tests and benchmarks were extended. Part of these developments was sponsored by the European Space Agency in the context of research aimed at modelling radiation biological end effects. In this work, we present an overview of results of several benchmarks for electromagnetic physics models relevant to space science. For electromagnetic physics, recently Compton scattering, photoelectric effect, and Rayleigh scattering models have been improved and extended down to lower energies. Models of ionization and fluctuations have also been improved; special micro-dosimetry models for Silicon and liquid water were introduced; the main multiple scattering model was consolidated; and the atomic de-excitation module has been made available to all models. As a result, Geant4 predictions for space radiation effects obtained with different Physics Lists are in better agreement with the benchmark data than previous Geant4 versions. Here we present results of electromagnetic tests and models comparison in the energy interval 10 eV - 10 MeV.

  18. Bolivia's economy--an update.

    Science.gov (United States)

    Weisbrot, Mark; Sandoval, Luis

    2008-01-01

    This report looks at Bolivia's main economic indicators over the past year (mid-2006 to mid-2007), noting improvements in growth, fiscal balances, balance of payments, and international reserves. These improvements were largely due to government policies and choices, such as increased hydrocarbons royalties and control over the hydrocarbons sector, and have allowed the government to embark on a number of programs targeting the poor and landless. The report also notes that Bolivia faces many challenges: expansion of land reform, more rapid growth and poverty reduction, the reduction of regional and demographic disparities, and an accelerated diversification of the economy away from hydrocarbons and minerals.

  19. Screening of the hearing of newborns - Update

    Directory of Open Access Journals (Sweden)

    von Voß, Hubertus

    2006-11-01

    our former health technology assessment report was updated. Results: Universal newborn hearing screening programs are able to substantially reduce the age at identification and the age at intervention of children with CHL to six months of age in the German health care setting. High coverage rates, low fail rates and - if tracking systems are implemented – high follow-up-rates to diagnostic evaluation for test positives were achieved. New publications on potential benefits of early intervention could not be retrieved. For a final assessment of cost-effectiveness of newborn hearing screening evidence based long-term data are lacking. Decision analytic models with lifelong time horizon assuming that early detection results in improved language abilities and lower educational costs and higher life time productivity showed a potential of UNHS for long term cost savings compared to selective screening and no screening. For the short-term cost-effectiveness with a time horizon up to diagnostic evaluation more evidence based data are available. The average costs per case diagnosed range from 16,000 EURO to 33,600 EURO in Germany and hence are comparable to the cost of other implemented newborn screening programs. Empirical data for cost of selective screening in the German health care setting are lacking. Our decision analytic model shows that selective screening is more cost-effective but detects only 50% of all cases of congenital hearing loss. Discussion: There is good evidence that UNHS-Programs with appropriate quality management can reduce the age at start of intervention below six months. Up to now there is no indication of considerable negative consequences of screening for children with false positive test results and their parents. However, it is more difficult to prove the efficacy of early intervention to improve long-term outcomes. Randomized clinical trials of the efficacy of early intervention for children with CHL hearing losses are inappropriate because of

  20. A Provenance Tracking Model for Data Updates

    Directory of Open Access Journals (Sweden)

    Gabriel Ciobanu

    2012-08-01

    Full Text Available For data-centric systems, provenance tracking is particularly important when the system is open and decentralised, such as the Web of Linked Data. In this paper, a concise but expressive calculus which models data updates is presented. The calculus is used to provide an operational semantics for a system where data and updates interact concurrently. The operational semantics of the calculus also tracks the provenance of data with respect to updates. This provides a new formal semantics extending provenance diagrams which takes into account the execution of processes in a concurrent setting. Moreover, a sound and complete model for the calculus based on ideals of series-parallel DAGs is provided. The notion of provenance introduced can be used as a subjective indicator of the quality of data in concurrent interacting systems.

  1. Performance Evaluation of Biometric Template Update

    CERN Document Server

    Giot, Romain; Dorizzi, Bernadette

    2012-01-01

    Template update allows to modify the biometric reference of a user while he uses the biometric system. With such kind of mechanism we expect the biometric system uses always an up to date representation of the user, by capturing his intra-class (temporary or permanent) variability. Although several studies exist in the literature, there is no commonly adopted evaluation scheme. This does not ease the comparison of the different systems of the literature. In this paper, we show that using different evaluation procedures can lead in different, and contradictory, interpretations of the results. We use a keystroke dynamics (which is a modality suffering of template ageing quickly) template update system on a dataset consisting of height different sessions to illustrate this point. Even if we do not answer to this problematic, it shows that it is necessary to normalize the template update evaluation procedures.

  2. The neural dynamics of updating person impressions.

    Science.gov (United States)

    Mende-Siedlecki, Peter; Cai, Yang; Todorov, Alexander

    2013-08-01

    Person perception is a dynamic, evolving process. Because other people are an endless source of social information, people need to update their impressions of others based upon new information. We devised an fMRI study to identify brain regions involved in updating impressions. Participants saw faces paired with valenced behavioral information and were asked to form impressions of these individuals. Each face was seen five times in a row, each time with a different behavioral description. Critically, for half of the faces the behaviors were evaluatively consistent, while for the other half they were inconsistent. In line with prior work, dorsomedial prefrontal cortex (dmPFC) was associated with forming impressions of individuals based on behavioral information. More importantly, a whole-brain analysis revealed a network of other regions associated with updating impressions of individuals who exhibited evaluatively inconsistent behaviors, including rostrolateral PFC, superior temporal sulcus, right inferior parietal lobule and posterior cingulate cortex.

  3. Surveillance, response systems, and evidence updates on emerging zoonoses: the role of one health.

    Science.gov (United States)

    Asokan, G V; Kasimanickam, Ramanathan K; Asokan, Vanitha

    2013-01-01

    Globally, emerging zoonotic diseases are increasing. Existing surveillance systems for zoonoses have substantial gaps, especially in developing countries, and the systems in place in the developed world require improvements. Resources and updates on evidence-based practice (EBP) for zoonoses are sparser in the veterinary literature as compared to the medical literature. Evidence updates for emerging zoonoses are either absent or rudimentary in both human and veterinary medicine. A 'one-health' concept, including a global signaling surveillance system for emerging zoonoses, will be essential for correct diagnoses, interventions, and public health strategies. An open access EBP platform supported by builders of EBP resources is urgently needed to counter emerging zoonoses.

  4. Update of the Z Refurbishment project (ZR) at Sandia National Laboratories.

    Energy Technology Data Exchange (ETDEWEB)

    Moncayo, Carla; Bloomquist, Douglas D.; Weed, John Woodruff; Tabor, Debra Ann; Donovan, Guy Louis; McKee, G. Randall; Weinbrecht, Edward A.; Faturos, Thomas V.; McDaniel, Dillon Heirman

    2007-08-01

    Sandia's Z Refurbishment (ZR) Project formally began in February 2002 to increase the Z Accelerator's utilization by providing the capability to perform more shots, improve precision and pulse shape variability, and increase delivered current. A project update was provided at the 15th International Pulsed Power Conference in 2005. The Z facility was shut down in July 2006 for structural/infrastructure modifications and installation of new pulsed power systems. The refurbishment will conclude in 2007. This paper provides a status update of the project covering the past 2 years of activities.

  5. Updated U.S. Geothermal Supply Characterization and Representation for Market Penetration Model Input

    Energy Technology Data Exchange (ETDEWEB)

    Augustine, C.

    2011-10-01

    The U.S. Department of Energy (DOE) Geothermal Technologies Program (GTP) tasked the National Renewable Energy Laboratory (NREL) with conducting the annual geothermal supply curve update. This report documents the approach taken to identify geothermal resources, determine the electrical producing potential of these resources, and estimate the levelized cost of electricity (LCOE), capital costs, and operating and maintenance costs from these geothermal resources at present and future timeframes under various GTP funding levels. Finally, this report discusses the resulting supply curve representation and how improvements can be made to future supply curve updates.

  6. Sensitivity-based finite element model updating using constrained optimization with a trust region algorithm

    Science.gov (United States)

    Bakir, Pelin Gundes; Reynders, Edwin; De Roeck, Guido

    2007-08-01

    The use of changes in dynamic system characteristics to detect damage has received considerable attention during the last years. Within this context, FE model updating technique, which belongs to the class of inverse problems in classical mechanics, is used to detect, locate and quantify damage. In this study, a sensitivity-based finite element (FE) model updating scheme using a trust region algorithm is developed and implemented in a complex structure. A damage scenario is applied on the structure in which the stiffness values of the beam elements close to the beam-column joints are decreased by stiffness reduction factors. A worst case and complex damage pattern is assumed such that the stiffnesses of adjacent elements are decreased by substantially different stiffness reduction factors. The objective of the model updating is to minimize the differences between the eigenfrequency and eigenmodes residuals. The updating parameters of the structure are the stiffness reduction factors. The changes of these parameters are determined iteratively by solving a nonlinear constrained optimization problem. The FE model updating algorithm is also tested in the presence of two levels of noise in simulated measurements. In all three cases, the updated MAC values are above 99% and the relative eigenfrequency differences improve substantially after model updating. In cases without noise and with moderate levels of noise; detection, localization and quantification of damage are successfully accomplished. In the case with substantially noisy measurements, detection and localization of damage are successfully realized. Damage quantification is also promising in the presence of high noise as the algorithm can still predict 18 out of 24 damage parameters relatively accurately in that case.

  7. The updating of clinical practice guidelines: insights from an international survey

    Directory of Open Access Journals (Sweden)

    Solà Ivan

    2011-09-01

    Full Text Available Abstract Background Clinical practice guidelines (CPGs have become increasingly popular, and the methodology to develop guidelines has evolved enormously. However, little attention has been given to the updating process, in contrast to the appraisal of the available literature. We conducted an international survey to identify current practices in CPG updating and explored the need to standardize and improve the methods. Methods We developed a questionnaire (28 items based on a review of the existing literature about guideline updating and expert comments. We carried out the survey between March and July 2009, and it was sent by email to 106 institutions: 69 members of the Guidelines International Network who declared that they developed CPGs; 30 institutions included in the U.S. National Guideline Clearinghouse database that published more than 20 CPGs; and 7 institutions selected by an expert committee. Results Forty-four institutions answered the questionnaire (42% response rate. In the final analysis, 39 completed questionnaires were included. Thirty-six institutions (92% reported that they update their guidelines. Thirty-one institutions (86% have a formal procedure for updating their guidelines, and 19 (53% have a formal procedure for deciding when a guideline becomes out of date. Institutions describe the process as moderately rigorous (36% or acknowledge that it could certainly be more rigorous (36%. Twenty-two institutions (61% alert guideline users on their website when a guideline is older than three to five years or when there is a risk of being outdated. Twenty-five institutions (64% support the concept of "living guidelines," which are continuously monitored and updated. Eighteen institutions (46% have plans to design a protocol to improve their guideline-updating process, and 21 (54% are willing to share resources with other organizations. Conclusions Our study is the first to describe the process of updating CPGs among prominent

  8. Indoor Spatial Updating with Reduced Visual Information.

    Directory of Open Access Journals (Sweden)

    Gordon E Legge

    Full Text Available Spatial updating refers to the ability to keep track of position and orientation while moving through an environment. People with impaired vision may be less accurate in spatial updating with adverse consequences for indoor navigation. In this study, we asked how artificial restrictions on visual acuity and field size affect spatial updating, and also judgments of the size of rooms.Normally sighted young adults were tested with artificial restriction of acuity in Mild Blur (Snellen 20/135 and Severe Blur (Snellen 20/900 conditions, and a Narrow Field (8° condition. The subjects estimated the dimensions of seven rectangular rooms with and without these visual restrictions. They were also guided along three-segment paths in the rooms. At the end of each path, they were asked to estimate the distance and direction to the starting location. In Experiment 1, the subjects walked along the path. In Experiment 2, they were pushed in a wheelchair to determine if reduced proprioceptive input would result in poorer spatial updating.With unrestricted vision, mean Weber fractions for room-size estimates were near 20%. Severe Blur but not Mild Blur yielded larger errors in room-size judgments. The Narrow Field was associated with increased error, but less than with Severe Blur. There was no effect of visual restriction on estimates of distance back to the starting location, and only Severe Blur yielded larger errors in the direction estimates. Contrary to expectation, the wheelchair subjects did not exhibit poorer updating performance than the walking subjects, nor did they show greater dependence on visual condition.If our results generalize to people with low vision, severe deficits in acuity or field will adversely affect the ability to judge the size of indoor spaces, but updating of position and orientation may be less affected by visual impairment.

  9. Kenya Economic Update, October 2016

    OpenAIRE

    2016-01-01

    Kenya is one of the bright spots in Sub-Saharan Africa. With economic growth rates sustained at above 5 percent, Kenya has outperformed the regional average, for 8 consecutive years. Robust domestic demand emanating from private consumption and government investment are the key drivers of growth, underpinned by a stable macroeconomic environment, lower oil prices, diversification, improved...

  10. Thailand : Investment Climate Assessment Update

    OpenAIRE

    World Bank

    2008-01-01

    This report provides an up-to-date assessment of the investment climate of Thailand. As the socio-economic framework in which enterprises operate including infrastructure, policies and regulations improving the investment climate is helpful for productivity and economic growth. The report is based mainly on the results of the second round of the Thailand Productivity and Investment Climate...

  11. INTESTINAL TRANSPLANTATION - A CLINICAL UPDATE

    NARCIS (Netherlands)

    PLOEG, RJ; DALESSANDRO, AM

    1995-01-01

    Background: Until very recently the results of clinical small-bowel transplantation were disappointing. The latest developments indicate, however, that significant improvements have been made towards clinical application of this mode of therapy for patients with short-bowel syndrome. Methods: Becaus

  12. Erythropoietin: physiology and pharmacology update.

    Science.gov (United States)

    Fisher, James W

    2003-01-01

    This minireview is an update of a 1997 review on erythropoietin (EPO) in this journal. EPO is a 30,400-dalton glycoprotein that regulates red cell production. In the human, EPO is produced by peritubular cells in the kidneys of the adult and in hepatocytes in the fetus. Small amounts of extra-renal EPO are produced by the liver in adult human subjects. EPO binds to an erythroid progenitor cell surface receptor that includes a p66 chain, and, when activated, the p66 protein becomes dimerized. EPO receptor activation induces a JAK2 tyrosine kinase, which leads to tyrosine phosphorylation of the EPO receptor and several proteins. EPO receptor binding leads to intracellular activation of the Ras/mitogen-activated kinase pathway, which is involved with cell proliferation, phosphatidylinositol 3-kinase, and STATS 1, 3, 5A, and 5B transcriptional factors. EPO acts primarily to rescue erythroid cells from apoptosis (programmed cell death) to increase their survival. EPO acts synergistically with several growth factors (SCF, GM-CSF, 1L-3, and IGF-1) to cause maturation and proliferation of erythroid progenitor cells (primarily colony-forming unit-E). Oxygen-dependent regulation of EPO gene expression is postulated to be controlled by a hypoxia-inducible transcription factor (HIF-1alpha). Hypoxia-inducible EPO production is controlled by a 50-bp hypoxia-inducible enhancer that is approximately 120 bp 3' to the polyadenylation site. Hypoxia signal transduction pathways involve kinases A and C, phospholipase A(2), and transcription factors ATF-1 and CREB-1. A model has been proposed for adenosine activation of EPO production that involves protein kinases A and C and the phospholipase A(2) pathway. Other effects of EPO include a hematocrit-independent, vasoconstriction-dependent hypertension, increased endothelin production, upregulation of tissue renin, change in vascular tissue prostaglandins production, stimulation of angiogenesis, and stimulation of endothelial and vascular

  13. Globally coupled maps with asynchronous updating

    CERN Document Server

    Abramson, G; Abramson, Guillermo; Zanette, Damian H.

    1998-01-01

    We analyze a system of globally coupled logistic maps with asynchronous updating. We show that its dynamics differs considerably from that of the synchronous case. For growing values of the coupling intensity, an inverse bifurcation cascade replaces the structure of clusters and ordering in the phase diagram. We present numerical simulations and an analytical description based on an effective single-element dynamics affected by internal fluctuations. Both of them show how global coupling is able to suppress the complexity of the single-element evolution. We find that, in contrast to systems with synchronous update, internal fluctuations satisfy the law of large numbers.

  14. Brucellosis update in Libya and regional prospective.

    Science.gov (United States)

    Ahmed, Mohamed O; Abouzeed, Yousef M; Bennour, Emad M; van Velkinburgh, Jennifer C

    2015-02-01

    Brucellosis is a global bacterial zoonosis responsible for high morbidity in humans and significant livestock economic losses. While brucellosis remains a public health concern worldwide, its global geographic distribution is variable, largely due to different management schemes; however, paucity of information renders the status of brucellosis unclear and incomplete in many countries, especially those with low income and under-developed infrastructure. This short article summarizes and discusses recent important updates on brucellosis from the North African countries, with a particular brief emphasis on the current status and recent updates in Libya.

  15. The Molecular Biology Database Collection: 2008 update.

    Science.gov (United States)

    Galperin, Michael Y

    2008-01-01

    The Nucleic Acids Research online Molecular Biology Database Collection is a public repository that lists more than 1000 databases described in this and previous Nucleic Acids Research annual database issues, as well as a selection of molecular biology databases described in other journals. All databases included in this Collection are freely available to the public. The 2008 update includes 1078 databases, 110 more than the previous one. The links to more than 80 databases have been updated and 25 obsolete databases have been removed from the list. The complete database list and summaries are available online at the Nucleic Acids Research web site, http://nar.oxfordjournals.org/.

  16. Update in clinical allergy and immunology.

    Science.gov (United States)

    von Gunten, S; Marsland, B J; von Garnier, C; Simon, D

    2012-12-01

    In the recent years, a tremendous body of studies has addressed a broad variety of distinct topics in clinical allergy and immunology. In this update, we discuss selected recent data that provide clinically and pathogenetically relevant insights or identify potential novel targets and strategies for therapy. The role of the microbiome in shaping allergic immune responses and molecular, as well as cellular mechanisms of disease, is discussed separately and in the context of atopic dermatitis, as an allergic model disease. Besides summarizing novel evidence, this update highlights current areas of uncertainties and debates that, as we hope, shall stimulate scientific discussions and research activities in the field.

  17. State energy-price system: 1981 update

    Energy Technology Data Exchange (ETDEWEB)

    Fang, J.M.; Imhoff, K.L.; Hood, L.J.

    1983-08-01

    This report updates the State Energy Price Data System (STEPS) to include state-level energy prices by fuel and by end-use sectors for 1981. Both physical unit prices and Btu prices are presented. Basic documentation of the data base remains generally the same as in the original report: State Energy Price System; Volume 1: Overview and Technical Documentation (DOE/NBB-0029 Volume 1 of 2, November 1982). The present report documents only the changes in procedures necessitated by the update to 1981 and the corrections to the basic documentation.

  18. Concepts of incremental updating and versioning

    CSIR Research Space (South Africa)

    Cooper, Antony K

    2004-07-01

    Full Text Available . BACKGROUND TO THE PROBLEM OF INCREMENTAL UPDATING AND VERSIONING As well as a number of Commissions, the International Cartographic Association (ICA) had one Working Group, on Incremental Updating and Versioning, and this presentation describes some... of the work undertaken recently by the Working Group (WG). The WG was voted for a Commission by the General Assembly held at the 21st ICC in Durban, South Africa. The basic problem being addressed by the Commission is that a user compiles their data base...

  19. Updating of PGAA system at HANARO research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Jeo, H. J.; Kim, S. H.; Moon, J. H.; Jeong, Y. S.; Kim, Y. J. [KAERI, Taejon (Korea, Republic of)

    2003-10-01

    In this study, updating of Prompt Gamma-ray neutron Activation Analysis system (PGAA) has been carried out to obtain the best, optimal condition through the improvement of neutron flux and reduction of background of PGAA facility which is installed on the ST 1 horizontal beam port at HANARO research reactor. Both diffracted beam profiling's conditions and the neutron diffraction of pyrolytic graphite crystals are investigated by BF{sub 3} counter, laser and optical diffraction angle control method to confirm the beam convergence rate. Also, the effects of interference materials such as aluminum sample holder, teflon holder and Teflon wire appeared from analyzing elemental constituent are investigated with single - and Compton mode. After readjusting of system, the neutron flux measured was 8.1{+-}0.2 x 10{sup 7} n{center_dot}cm{sup -2}{center_dot}s{sup -1} increasing about 40%, to be expected the improved analytical sensitivity.

  20. An Allele Real-Coded Quantum Evolutionary Algorithm Based on Hybrid Updating Strategy.

    Science.gov (United States)

    Zhang, Yu-Xian; Qian, Xiao-Yi; Peng, Hui-Deng; Wang, Jian-Hui

    2016-01-01

    For improving convergence rate and preventing prematurity in quantum evolutionary algorithm, an allele real-coded quantum evolutionary algorithm based on hybrid updating strategy is presented. The real variables are coded with probability superposition of allele. A hybrid updating strategy balancing the global search and local search is presented in which the superior allele is defined. On the basis of superior allele and inferior allele, a guided evolutionary process as well as updating allele with variable scale contraction is adopted. And H ε gate is introduced to prevent prematurity. Furthermore, the global convergence of proposed algorithm is proved by Markov chain. Finally, the proposed algorithm is compared with genetic algorithm, quantum evolutionary algorithm, and double chains quantum genetic algorithm in solving continuous optimization problem, and the experimental results verify the advantages on convergence rate and search accuracy.

  1. An Allele Real-Coded Quantum Evolutionary Algorithm Based on Hybrid Updating Strategy

    Directory of Open Access Journals (Sweden)

    Yu-Xian Zhang

    2016-01-01

    Full Text Available For improving convergence rate and preventing prematurity in quantum evolutionary algorithm, an allele real-coded quantum evolutionary algorithm based on hybrid updating strategy is presented. The real variables are coded with probability superposition of allele. A hybrid updating strategy balancing the global search and local search is presented in which the superior allele is defined. On the basis of superior allele and inferior allele, a guided evolutionary process as well as updating allele with variable scale contraction is adopted. And Hε gate is introduced to prevent prematurity. Furthermore, the global convergence of proposed algorithm is proved by Markov chain. Finally, the proposed algorithm is compared with genetic algorithm, quantum evolutionary algorithm, and double chains quantum genetic algorithm in solving continuous optimization problem, and the experimental results verify the advantages on convergence rate and search accuracy.

  2. Particle filter with importance density function generated by updated system equation

    Institute of Scientific and Technical Information of China (English)

    左军毅; 贾颖娜; 张炜; 高全学

    2013-01-01

    The current measurement was exploited in a more efficient way. Firstly, the system equation was updated by introducing a correction term, which depends on the current measurement and can be obtained by running a suboptimal filter. Then, a new importance density function(IDF) was defined by the updated system equation. Particles drawn from the new IDF are more likely to be in the significant region of state space and the estimation accuracy can be improved. By using different suboptimal filter, different particle filters(PFs) can be developed in this framework. Extensions of this idea were also proposed by iteratively updating the system equation using particle filter itself, resulting in the iterated particle filter. Simulation results demonstrate the effectiveness of the proposed IDF.

  3. Pattern Recognition Using Carbon Nanotube Synaptic Transistors with an Adjustable Weight Update Protocol.

    Science.gov (United States)

    Kim, Sungho; Choi, Bongsik; Lim, Meehyun; Yoon, Jinsu; Lee, Juhee; Kim, Hee-Dong; Choi, Sung-Jin

    2017-03-28

    Recent electronic applications require an efficient computing system that can perform data processing with limited energy consumption. Inspired by the massive parallelism of the human brain, a neuromorphic system (hardware neural network) may provide an efficient computing unit to perform such tasks as classification and recognition. However, the implementation of synaptic devices (i.e., the essential building blocks for emulating the functions of biological synapses) remains challenging due to their uncontrollable weight update protocol and corresponding uncertain effects on the operation of the system, which can lead to a bottleneck in the continuous design and optimization. Here, we demonstrate a synaptic transistor based on highly purified, preseparated 99% semiconducting carbon nanotubes, which can provide adjustable weight update linearity and variation margin. The pattern recognition efficacy is validated using a device-to-system level simulation framework. The enlarged margin rather than the linear weight update can enhance the fault tolerance of the recognition system, which improves the recognition accuracy.

  4. CyanoBase: a large-scale update on its 20th anniversary

    Science.gov (United States)

    Fujisawa, Takatomo; Narikawa, Rei; Maeda, Shin-ichi; Watanabe, Satoru; Kanesaki, Yu; Kobayashi, Koichi; Nomata, Jiro; Hanaoka, Mitsumasa; Watanabe, Mai; Ehira, Shigeki; Suzuki, Eiji; Awai, Koichiro; Nakamura, Yasukazu

    2017-01-01

    The first ever cyanobacterial genome sequence was determined two decades ago and CyanoBase (http://genome.microbedb.jp/cyanobase), the first database for cyanobacteria was simultaneously developed to allow this genomic information to be used more efficiently. Since then, CyanoBase has constantly been extended and has received several updates. Here, we describe a new large-scale update of the database, which coincides with its 20th anniversary. We have expanded the number of cyanobacterial genomic sequences from 39 to 376 species, which consists of 86 complete and 290 draft genomes. We have also optimized the user interface for large genomic data to include the use of semantic web technologies and JBrowse and have extended community-based reannotation resources through the re-annotation of Synechocystis sp. PCC 6803 by the cyanobacterial research community. These updates have markedly improved CyanoBase, providing cyanobacterial genome annotations as references for cyanobacterial research. PMID:27899668

  5. Adaptive update using visual models for lifting-based motion-compensated temporal filtering

    Science.gov (United States)

    Li, Song; Xiong, H. K.; Wu, Feng; Chen, Hong

    2005-03-01

    Motion compensated temporal filtering is a useful framework for fully scalable video compression schemes. However, when supposed motion models cannot represent a real motion perfectly, both the temporal high and the temporal low frequency sub-bands may contain artificial edges, which possibly lead to a decreased coding efficiency, and ghost artifacts appear in the reconstructed video sequence at lower bit rates or in case of temporal scaling. We propose a new technique that is based on utilizing visual models to mitigate ghosting artifacts in the temporal low frequency sub-bands. Specifically, we propose content adaptive update schemes where visual models are used to determine image dependent upper bounds on information to be updated. Experimental results show that the proposed algorithm can significantly improve subjective visual quality of the low-pass temporal frames and at the same time, coding performance can catch or exceed the classical update steps.

  6. Soft sensor modelling by time difference, recursive partial least squares and adaptive model updating

    Science.gov (United States)

    Fu, Y.; Yang, W.; Xu, O.; Zhou, L.; Wang, J.

    2017-04-01

    To investigate time-variant and nonlinear characteristics in industrial processes, a soft sensor modelling method based on time difference, moving-window recursive partial least square (PLS) and adaptive model updating is proposed. In this method, time difference values of input and output variables are used as training samples to construct the model, which can reduce the effects of the nonlinear characteristic on modelling accuracy and retain the advantages of recursive PLS algorithm. To solve the high updating frequency of the model, a confidence value is introduced, which can be updated adaptively according to the results of the model performance assessment. Once the confidence value is updated, the model can be updated. The proposed method has been used to predict the 4-carboxy-benz-aldehyde (CBA) content in the purified terephthalic acid (PTA) oxidation reaction process. The results show that the proposed soft sensor modelling method can reduce computation effectively, improve prediction accuracy by making use of process information and reflect the process characteristics accurately.

  7. Study of Updating Initiating Event Frequency using Prognostics

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyeonmin; Lee, Sang-Hwan; Park, Jun-seok; Kim, Hyungdae; Chang, Yoon-Suk; Heo, Gyunyoung [Kyung Hee Univ., Yongin (Korea, Republic of)

    2014-10-15

    The Probabilistic Safety Assessment (PSA) model enables to find the relative priority of accident scenarios, weak points in achieving accident prevention or mitigation, and insights to improve those vulnerabilities. Thus, PSA consider realistic calculation for precise and confidence results. However, PSA model still 'conservative' aspects in the procedures of developing a PSA model. One of the sources for the conservatism is caused by the assumption of safety analysis and the estimation of failure frequency. Recently, Surveillance, Diagnosis, and Prognosis (SDP) is a growing trend in applying space and aviation systems in particular. Furthermore, a study dealing with the applicable areas and state-of-the-art status of the SDP in nuclear industry was published. SDP utilizing massive database and information technology among such enabling techniques is worthwhile to be highlighted in terms of the capability of alleviating the conservatism in the conventional PSA. This paper review the concept of integrating PSA and SDP and suggest the updated methodology of Initiating Event (IE) using prognostics. For more detailed, we focus on IE of the Steam Generator Tube Rupture (SGTR) considering tube degradation. This paper is additional research of previous our suggested the research. In this paper, the concept of integrating PSA and SDP are suggested. Prognostics algorithms in SDP are applied at IE, Bes in the Level 1 PSA. As an example, updating SGTR IE and its ageing were considered. Tube ageing were analyzed by using PASTA and Monte Carlo method. After analyzing the tube ageing, conventional SGTR IE were updated by using Bayesian approach. The studied method can help to cover the static and conservatism in PSA.

  8. Stata Hybrids: Updates and Ideas

    Science.gov (United States)

    Fieldler, James

    2014-01-01

    At last year's Stata conference I presented two projects for using Python with Stata: a plugin that embeds the Python programming language within Stata and code for using Stata data sets in Python. In this talk I will describe some small improvements being made to these projects, and I will present other ideas for combining tools with Stata. Some of these ideas use Python, some use JavaScript and a web browser.

  9. 100% DD Energy Model Update

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2011-06-30

    The Miami Science Museum energy model has been used during DD to test the building's potential for energy savings as measured by ASHRAE 90.1-2007 Appendix G. This standard compares the designed building's yearly energy cost with that of a code-compliant building. The building is currently on track show 20% or better improvement over the ASHRAE 90.1-2007 Appendix G baseline; this performance would ensure minimum compliance with both LEED 2.2 and current Florida Energy Code, which both reference a less strict version of ASHRAE 90.1. In addition to being an exercise in energy code compliance, the energy model has been used as a design tool to show the relative performance benefit of individual energy conservation measures (ECMs). These ECMs are areas where the design team has improved upon code-minimum design paths to improve the energy performance of the building. By adding ECMs one a time to a code-compliant baseline building, the current analysis identifies which ECMs are most effective in helping the building meet its energy performance goals.

  10. Improving NORTHCOM’s DSCA Capabilities

    Science.gov (United States)

    2014-05-15

    chemical, and to a lesser extent, medical units. These challenges diminish the value of the extreme levels of readiness maintained by these allocated... medical units—take measures to improve deployability, including routinely updating Unit Equipment Lists (UELs) in JOPES, and reporting UEL updates in...Unfortunately, the planning that occurs post-incident is largely “crisis-action” planning instead of deliberate planning, and subject to hurried , stove-piped

  11. Silicone Gel-Filled Breast Implants: Updated Safety Information

    Science.gov (United States)

    ... For Consumers Home For Consumers Consumer Updates Silicone Gel-Filled Breast Implants: Updated Safety Information Share Tweet ... When the Food and Drug Administration allowed silicone gel-filled breast implants back on the market in ...

  12. Sublingual immunotherapy: World Allergy Organization position paper 2013 update

    NARCIS (Netherlands)

    G.W. Canonica (Giorgio Walter); L. Cox (Linda); R. Pawankar (Ruby); C.E. Baena-Cagnani (Carlos); M.S. Blaiss (Michael); S. Bonini (Sergio); J. Bousquet (Jean); M. Calderon (Moises); E. Compalati (Enrico); S.R. Durham (Stephen); R. Gerth van Wijk (Roy); D. Larenas-Linnemann (Désirée); H. Nelson (Harold); G. Passalacqua (Giovanni); O. Pfaar (Oliver); K. Rosario (Karyna); D. Ryan (Dermot); L. Rosenwasser (Lanny); P. Schmid-Grendelmeier (Peter); G.E. Senna (Gianenrico); E. Valovirta (Erkka); H.P. van Bever (Hugo); P. Vichyanond (Pakit); U. Wahn (Ulrich); O.M. Yusuf (Osman)

    2014-01-01

    textabstractWe have prepared this document, "Sublingual Immunotherapy: World Allergy Organization Position Paper 2013 Update", according to the evidence-based criteria, revising and updating chapters of the originally published paper, "Sublingual Immunotherapy: World Allergy Organization Position Pa

  13. Rebuild America partner update, November--December 1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-11-01

    This issue of the update includes articles on retrofitting Duke University facilities, energy efficiency updates to buildings in Portland, Oregon, Salisbury, North Carolina, Hawaii, Roanoke-Chowan, Virginia, and energy savings centered designs for lighting systems.

  14. Legislative Update, June 2010. Report 10-13

    Science.gov (United States)

    Blair, Julia

    2010-01-01

    This update contains analyses of legislation being tracked by California Postsecondary Education Commission (CPEC) staff. It has updated positions on bills as adopted in the Commission meeting on June 8. A matrix of bills tracked by CPEC staff is included.

  15. News and Features Updates from USA.gov

    Data.gov (United States)

    General Services Administration — Stay on top of important government news and information with the USA.gov Updates: News and Features RSS feed. We'll update this feed when we add news and featured...

  16. Sublingual immunotherapy: World Allergy Organization position paper 2013 update

    NARCIS (Netherlands)

    G.W. Canonica (Giorgio Walter); L. Cox (Linda); R. Pawankar (Ruby); C.E. Baena-Cagnani (Carlos); M.S. Blaiss (Michael); S. Bonini (Sergio); J. Bousquet (Jean); M. Calderon (Moises); E. Compalati (Enrico); S.R. Durham (Stephen); R. Gerth van Wijk (Roy); D. Larenas-Linnemann (Désirée); H. Nelson (Harold); G. Passalacqua (Giovanni); O. Pfaar (Oliver); K. Rosario (Karyna); D. Ryan (Dermot); L. Rosenwasser (Lanny); P. Schmid-Grendelmeier (Peter); G.E. Senna (Gianenrico); E. Valovirta (Erkka); H.P. van Bever (Hugo); P. Vichyanond (Pakit); U. Wahn (Ulrich); O.M. Yusuf (Osman)

    2014-01-01

    textabstractWe have prepared this document, "Sublingual Immunotherapy: World Allergy Organization Position Paper 2013 Update", according to the evidence-based criteria, revising and updating chapters of the originally published paper, "Sublingual Immunotherapy: World Allergy Organization Position

  17. Update to the Coordinated Framework for the Regulation of Biotechnology

    Science.gov (United States)

    This Update to the Coordinated Framework for the Regulation of Biotechnology updates earlier versions from 1986 and 1992 is intended to clarify the current roles and responsibilities of agencies involved in the regulation of biotechnology products.

  18. An Update on Planet Nine

    Science.gov (United States)

    Kohler, Susanna

    2016-07-01

    Whats the news coming from the research world on the search for Planet Nine? Read on for an update from a few of the latest studies.Artists illustration of Planet Nine, a hypothesized Neptune-sized planet orbiting in the distant reaches of our solar system. [Caltech/Robert Hurt]What is Planet Nine?In January of this year, Caltech researchers Konstantin Batygin and Mike Brown presented evidence of a distant ninth planet in our solar system. They predicted this planet to be of a mass and volume consistent with a super-Earth, orbiting on a highly eccentric pathwith a period of tens of thousands of years.Since Batygin and Browns prediction, scientists have been hunting for further signs of Planet Nine. Though we havent yet discovered an object matching its description, we have come up with new strategies for finding it, we set some constraints on where it might be, and we made some interesting theoretical predictions about its properties.Visualizations of the resonant orbits of the four longest-period Kuiper belt objects, depicted in a frame rotating with the mean angular velocity of Planet Nine. Planet Nines position is on the right (with the trace of possible eccentric orbits e=0.17 and e=0.4 indicated in red). [Malhotra et al 2016]Here are some of the newest constraints on Planet Nine from studies published just within the past two weeks.Resonant OrbitsRenu Malhotra (University of Arizonas Lunar and Planetary Laboratory) and collaborators present further evidence of the shaping of solar system orbits by the hypothetical Planet Nine. The authors point out that the four longest-period Kuiper belt objects (KBOs) have orbital periods close to integer ratios with each other. Could it be that these outer KBOs have become locked into resonant orbits with a distant, massive body?The authors find that a distant planet orbiting with a period of ~17,117 years and a semimajor axis ~665 AU would have N/1 and N/2 period ratios with these four objects. If this is correct, it

  19. 2015 Update of the Discoveries of Isotopes

    CERN Document Server

    Thoennessen, M

    2016-01-01

    The 2015 update of the discovery of nuclide project is presented. Twenty new nuclides were observed for the first time in 2015. An overall review of all previous assignments was made in order to apply the discovery criteria consistently to all elements. In addition, a list of isotopes published so far only in conference proceedings or internal reports is included.

  20. Bangladesh Quarterly Economic Update - December 2014

    OpenAIRE

    Asian Development Bank

    2015-01-01

    The Bangladesh Quarterly Economic Update (QEU) has been produced by the Bangladesh Resident Mission of the Asian Development Bank since March 2001. The QEU provides information and analysis on Bangladesh’s macroeconomic and sector developments, key development challenges, and policy and institutional reforms. The QEU has wide readership in government, academia, development partners, private sector, and civil society.

  1. Bangladesh Quarterly Economic Update June 2014

    OpenAIRE

    Asian Development Bank

    2014-01-01

    The Bangladesh Quarterly Economic Update (QEU) has been produced by the Bangladesh Resident Mission of the Asian Development Bank since March 2001. The QEU provides information and analysis on Bangladesh’s macroeconomic and sector developments, key development challenges, and policy and institutional reforms. The QEU has wide readership in government, academia, development partners, private sector, and civil society.

  2. Bangladesh Quarterly Economic Update September 2014

    OpenAIRE

    Asian Development Bank

    2014-01-01

    The Bangladesh Quarterly Economic Update (QEU) has been produced by the Bangladesh Resident Mission of the Asian Development Bank since March 2001. The QEU provides information and analysis on Bangladesh’s macroeconomic and sector developments, key development challenges, and policy and institutional reforms. The QEU has wide readership in government, academia, development partners, private sector, and civil society.

  3. American Automobile and Light Truck Statistics Update

    Science.gov (United States)

    Feldman, Bernard J.

    2014-01-01

    Given that transportation is an essential topic in any Physics and Society or Energy course, it is necessary to have useful statistics on transportation in order to have a reasoned discussion on this topic. And a major component of the transportation picture is the automobile. This paper presents updated transportation statistics for American…

  4. American Automobile and Light Truck Statistics Update

    Science.gov (United States)

    Feldman, Bernard J.

    2014-01-01

    Given that transportation is an essential topic in any Physics and Society or Energy course, it is necessary to have useful statistics on transportation in order to have a reasoned discussion on this topic. And a major component of the transportation picture is the automobile. This paper presents updated transportation statistics for American…

  5. Sri Lanka Development Update, Fall 2016

    OpenAIRE

    2016-01-01

    The Sri Lanka development update report talks about the recent economic developments in Sri Lanka for the year 2015-2016. With no exception, Sri Lanka also faced the challenges of a trying global environment in 2015. Uncertainties in an election year that saw a major political transition contributed to elevate the risks stemming from global context. The accommodative policy choices supported ...

  6. 2016 updated MASCC/ESMO consensus recommendations

    DEFF Research Database (Denmark)

    Roila, Fausto; Warr, David; Hesketh, Paul J

    2017-01-01

    PURPOSE: An update of the recommendations for the prophylaxis of acute and delayed emesis induced by moderately emetogenic chemotherapy published after the last MASCC/ESMO antiemetic consensus conference in 2009 has been carried out. METHODS: A systematic literature search using PubMed from Janua...

  7. 2016 Updated MASCC/ESMO Consensus Recommendations

    DEFF Research Database (Denmark)

    Olver, Ian; Ruhlmann, Christina H.; Jahn, Franziska

    2017-01-01

    Purpose: The purpose of this review is to update the MASCC (Multinational Association of Supportive Care in Cancer) guidelines for controlling nausea and vomiting with chemotherapy of low or minimal emetic potential. Methods: The antiemetic study group of MASCC met in Copenhagen in 2015 to review...

  8. 2016 updated MASCC/ESMO consensus recommendations

    DEFF Research Database (Denmark)

    Ruhlmann, Christina H.; Jahn, Franziska; Jordan, Karin

    2017-01-01

    Purpose: Radiotherapy-induced nausea and vomiting (RINV) are distressing symptoms. Evidence-based guidelines should facilitate the prescription of the best possible antiemetic prophylaxis. As part of the MASCC/ESMO Antiemetic Guidelines Update 2016, a thorough review of the literature concerning...

  9. Young Children in Poverty: A Statistical Update.

    Science.gov (United States)

    Bennett, Neil G.; Li, Jiali; Song, Younghwan; Yang, Keming

    This document continues a series of statistical reports from the National Center for Children in Poverty about young child poverty in the United States. The highlights of this update include the current profile of extremely poor, poor, and near poor population of young children; an examination of the changing association between higher education…

  10. Treatment of advanced seminoma : An update

    NARCIS (Netherlands)

    Sleijfer, DT; Mulder, NH

    In this update, the recent developments in the treatment of patients with advanced seminoma are reviewed. Also, the approach for patients with residual disease after chemotherapy is described. It is concluded that the combination of etoposide and cisplatin seems to be the standard treatment for

  11. Discourse Updating after Reading a Counterfactual Event

    Science.gov (United States)

    de Vega, Manuel; Urrutia, Mabel

    2012-01-01

    This paper explores the temporal course of discourse updating after reading counterfactual events. To test the accessibility to discourse information, readers were asked to identify probes related to initial events in the text, previous to the counterfactual, or probes related to the critical counterfactual events. Experiment 1 showed that 500 ms…

  12. Optimizing Key Updates in Sensor Networks

    DEFF Research Database (Denmark)

    Yuksel, Ender; Nielson, Hanne Riis; Nielson, Flemming

    2011-01-01

    Sensor networks offer the advantages of simple and low–resource communication. Nevertheless, security is of particular importance in many cases such as when sensitive data is communicated or tamper-resistance is required. Updating the security keys is one of the key points in security, which rest...

  13. Update in cardiomyopathies and congestive heart failure

    Directory of Open Access Journals (Sweden)

    The Heart Hospital, London, UK and Monaldi Hospital, Naples, Italy

    2012-05-01

    Full Text Available This abstract book contains four reports and all abstracts presented to the Joint Meeting: Update in cardiomyopathies and congestive heart failure, 22-23 September 2011 - Naples, Italy, endorsed by the Working Group on Myocardial and Pericardial Diseases (WG 21 of the European Society of Cardiology (ESC.

  14. November 6, 2014 CDC Ebola Response Update

    Centers for Disease Control (CDC) Podcasts

    2014-11-06

    This podcast provides an update on the Ebola response, as of November 6, 2014.  Created: 11/6/2014 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 11/6/2014.

  15. December 17, 2014 CDC Ebola Response Update

    Centers for Disease Control (CDC) Podcasts

    2014-12-17

    This podcast provides an update on the Ebola response, as of December 17, 2014. It briefly describes CDC's "Operation Care Package.".  Created: 12/17/2014 by CDC’s Office of the Associate Director for Communication.   Date Released: 12/17/2014.

  16. November 19, 2014 CDC Ebola Response Update

    Centers for Disease Control (CDC) Podcasts

    2014-11-19

    This podcast provides an update on the Ebola response, as of November 19, 2014.  Created: 11/19/2014 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 11/19/2014.

  17. November 26, 2014 CDC Ebola Response Update

    Centers for Disease Control (CDC) Podcasts

    2014-11-26

    This podcast provides an update on the Ebola response, as of November 26, 2014. In this podcast, learn how CDC’s communications teams acknowledge the widespread fear of Ebola in messaging.  Created: 11/26/2014 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 11/26/2014.

  18. December 12, 2014 CDC Ebola Response Update

    Centers for Disease Control (CDC) Podcasts

    2014-12-12

    This podcast provides an update on the Ebola response, as of December 12, 2014. In this podcast, learn how some West African communities are celebrating their Ebola survivors.  Created: 12/12/2014 by CDC’s Office of the Associate Director for Communication.   Date Released: 12/12/2014.

  19. October 31, 2014 CDC Ebola Response Update

    Centers for Disease Control (CDC) Podcasts

    2014-10-31

    This podcast provides an update on the Ebola response, as of October 31, 2014.  Created: 10/31/2014 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 10/31/2014.

  20. November 14, 2014 CDC Ebola Response Update

    Centers for Disease Control (CDC) Podcasts

    2014-11-14

    This podcast provides an update on the Ebola response, as of November 14, 2014.  Created: 11/14/2014 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 11/14/2014.

  1. Clinical update on nursing home medicine: 2012.

    Science.gov (United States)

    Messinger-Rapport, Barbara J; Cruz-Oliver, Dulce M; Thomas, David R; Morley, John E

    2012-09-01

    This article is the sixth in the series of clinical updates on nursing home care. The topics covered are management of hypertension, antidepressant medications in people with dementia, peripheral arterial disease, probiotics in prevention, and treatment of Clostridium difficile-associated diarrhea, frailty, and falls.

  2. Updated Abraham solvation parameters for polychlorinated biphenyls

    NARCIS (Netherlands)

    van Noort, P.C.M.; Haftka, J.J.H.; Parsons, J.R.

    2010-01-01

    This study shows that the recently published polychlorinated biphenyl (PCB) Abraham solvation parameters predict PCB air−n-hexadecane and n-octanol−water partition coefficients very poorly, especially for highly ortho-chlorinated congeners. Therefore, an updated set of PCB solvation parameters was d

  3. [WWW.2CHEAT.COM] Update

    Science.gov (United States)

    Rooks, Clay D.

    2006-01-01

    This paper is an updated presentation on the subject of cheating and plagiarism via the World Wide Web. In a few hours searching the Internet, the author found even more "cheat" sites than in 1998 that offered not only all types of term and research papers, but college admission letters, reviews, case studies, even dissertations as well. Most now…

  4. Update of the exploratory report Acrolein

    NARCIS (Netherlands)

    Slooff W; Bont PFH; Janus JA; Pronk MEJ; Ros JPM; ECO; PPCbv; ACT; LAE

    1994-01-01

    The report is an update of the exploratory report acrolein (Slooff et al., 1991) that served as a basis for the discussion during the exploratory meeting on acrolein in March 1992. The meeting supported the conclusion that priority should be given to the compartment air and to the risks to humans.

  5. Lake Erie phosphorus loading and Cladophora updates

    Science.gov (United States)

    The presentation will focus on updates or progress being made on each Phosphorus Loadings and Cladophora for Lake Erie. The format will give a brief summary of data, findings, and results that were used by the Great Lakes Water Quality Agreement (GLWQA) Annex 4 Nutrients Modeli...

  6. Properties and Update Semantics of Consistent Views

    Science.gov (United States)

    1985-09-01

    8217 PR.OPERTIES AND UPDATE SEMANTICS OF CONSISTENT VIEWS G. Gottlob Institute for Applied Mathematics C.N.H.., G<•nova, Italy Compnt.<•r Sden... Gottlob G., Paolini P., Zicari R., "Proving Properties of Programs ou Database Views", Dipartiuwnto di Elcttronica, Politecnko di Milano (in

  7. Update on Co-Design @ Los Alamos

    Energy Technology Data Exchange (ETDEWEB)

    McPherson, Allen L. [Los Alamos National Laboratory

    2012-06-11

    We present an update on current co-design work at LANL. We describe three non-ASC co-design projects: CoCoMANS (LDRD), ExMatEx (ASCR) and the Co-Design Summer School (IS and T). For each project we give a brief overview of the project plans and status.

  8. Copyright Updates for K-12 Librarians

    Science.gov (United States)

    Johnson, Wendell G.

    2016-01-01

    Copyright concerns continue to bedevil K-12 librarians, who are often called upon to act as the copyright officers in public schools. This article describes recent copyright developments of concern to these librarians in three areas: a recent court case involving a university library, pending legislation supported by ALA, and a regulatory update.…

  9. Perception and Change in Update Logic

    NARCIS (Netherlands)

    Eijck, D.J.N. van; Eijck, D.J.N. van; Verbrugge, R.

    2011-01-01

    Abstract Three key ways of updating one's knowledge are (i) perception of states of affairs, e.g., seeing with one's own eyes that something is the case, (ii) recep- tion of messages, e.g., being told that something is the case, and (iii) drawing new conclusions from known facts. If one represents k

  10. Perception and Change in Update Logic

    NARCIS (Netherlands)

    Eijck, D.J.N. van; Verbrugge, R.

    2012-01-01

    Three key ways of updating one's knowledge are (i) perception of states of affairs, e.g., seeing with one's own eyes that something is the case, (ii) reception of messages, e.g., being told that something is the case, and (iii) drawing new conclusions from known facts. If one represents knowledge b

  11. Traffic Flow Management: Data Mining Update

    Science.gov (United States)

    Grabbe, Shon R.

    2012-01-01

    This presentation provides an update on recent data mining efforts that have been designed to (1) identify like/similar days in the national airspace system, (2) cluster/aggregate national-level rerouting data and (3) apply machine learning techniques to predict when Ground Delay Programs are required at a weather-impacted airport

  12. [Therapeutic update in cystic fibrosis].

    Science.gov (United States)

    Durupt, S; Nove Josserand, R; Durieu, I

    2014-06-01

    We present the recent therapeutic advances in the cystic fibrosis care. It concerns improvements in symptomatic treatment with the development of dry powder inhaled antibiotics that improved quality of life, and innovative treatments namely the modulators of the cystic fibrosis transmembrane protein conductance regulator (CFTR), molecules which act specifically at the level of the defective mechanisms implied in the disease. The life expectancy of cystic fibrosis patients born after 2000, is estimated now to be about 50 years. This improvement of survival was obtained with the organization of the care within the specialized centers for cystic fibrosis (Centre de ressource et de compétences de la mucoviscidose) and remains still based on heavy symptomatic treatments. Dry powder inhaled antibiotics constitute a significant time saving for patients to whom all the care can achieve two hours daily. Since 2012, the modulators of CFTR, molecules allowing a pharmacological approach targeted according to the type of the mutations, allows a more specific approach of the disease. Ivacaftor (Kalydeco(®)) which potentialises the function of the CFTR protein expressed on the cellular surface is now available for patients with the G551D mutation. Lumacaftor is going to be tested in association with ivacaftor in patients with the F508del mutation, that is present in at least 75% of the patients. The ataluren which allows the production of a functional protein CFTR in patients with a no sense mutation is the third representing of this new therapeutic class. We presently have numerous symptomatic treatments for the cystic fibrosis care. The development of CFTR modulators, today available to a restricted number of patients treated with ivacaftor represents a very promising therapeutic avenue. It will represent probably the first step to a personalized treatment according to CFTR genotype. Copyright © 2013 Société nationale française de médecine interne (SNFMI). Published by

  13. 7. Mentor update and support: what do mentors need from an update?

    Science.gov (United States)

    Phillips, Mari; Marshall, Joyce

    2015-04-01

    Mentorship is the 14th series of 'Midwifery basics' targeted at practising midwives. The aim of these articles is to provide information to raise awareness of the impact of the work of midwives on women's experience, and encourage midwives to seek further information through a series of activities relating to the topic. In this seventh article Mari Phillips and Joyce Marshall consider some of the key issues related to mentor update and support and consider what mentors need from their annual update.

  14. Transmyocardial revascularization devices: technology update

    Directory of Open Access Journals (Sweden)

    Kindzelski BA

    2014-12-01

    Full Text Available Bogdan A Kindzelski, Yifu Zhou, Keith A Horvath Cardiothoracic Surgery Research Program, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA Abstract: Transmyocardial laser revascularization (TMR emerged as treatment modality for patients with diffuse coronary artery disease not amendable to percutaneous or surgical revascularization. The procedure entails the creation of laser channels within ischemic myocardium in an effort to better perfuse these areas. Currently, two laser devices are approved by the US Food and Drug Administration for TMR – holmium:yttrium–aluminum–garnet and CO2. The two devices differ in regard to energy outputs, wavelengths, ability to synchronize with the heart cycle, and laser–tissue interactions. These differences have led to studies showing different efficacies between the two laser devices. Over 50,000 procedures have been performed worldwide using TMR. Improvements in angina stages, quality of life, and perfusion of the myocardium have been demonstrated with TMR. Although several mechanisms for these improvements have been suggested, evidence points to new blood vessel formation, or angiogenesis, within the treated myocardium, as the major contributory factor. TMR has been used as sole therapy and in combination with coronary artery bypass grafting. Clinical studies have demonstrated that TMR is both safe and effective in angina relief long term. The objective of this review is to present the two approved laser devices and evidence for the safety and efficacy of TMR, along with future directions with this technology. Keywords: laser, revascularization, angiogenesis, coronary artery disease

  15. Clinical update on contact allergy.

    Science.gov (United States)

    Uter, Wolfgang; Johansen, Jeanne Duus; Orton, David I; Frosch, Peter J; Schnuch, Axel

    2005-10-01

    The aim of this article is to review recent findings in contact allergy, regarding clinical research. The biocide methyldibromo glutaronitrile was identified to be an important sensitizer. Subsequently, it was banned from leave-on cosmetics in the European Union. Another group of important allergens that have been studied extensively included the fragrances oak moss absolute, isoeugenol, hydroxyisohexyl 3-cyclohexene carboxaldehyde and farnesol. A new fragrance mix II has been developed for standard testing, which includes the two latter compounds. Dose response studies have demonstrated broad individual variation of elicitation thresholds, dependent on the allergen concentration during induction, and other factors. Some unsuspected routes of exposure to allergens include oral, inhalational, connubial or airborne contact. Experimental studies provide a classification of newly introduced chemicals; increasingly, the local lymph node assay is supplementing and potentially replacing the guinea pig maximization test. Recent advances in occupational contact allergy include, for example, some attempts to improve diagnostics for epoxy resin and other plastic, glue, and cutting fluid components. Constant awareness for new allergens, confirmed by critical evaluation, standardization of patch test materials, and the identification of temporal patterns and subgroups at risk will improve both the diagnosis and prevention of allergic contact dermatitis.

  16. Update on developments at SNIF

    Energy Technology Data Exchange (ETDEWEB)

    Zacks, J., E-mail: jamie.zacks@ccfe.ac.uk; Turner, I.; Day, I.; Flinders, K.; McAdams, R. [CCFE, Culham Science Centre, Abingdon, Oxfordshire, OX14 3TR (United Kingdom); Crowley, B. [General Atomics, PO Box 85608, San Diego, California 92186-5608 (United States)

    2015-04-08

    The Small Negative Ion Facility (SNIF) at CCFE has been undergoing continuous development and enhancement to both improve operational reliability and increase diagnostic capability. SNIF uses a CW 13.56MHz, 5kW RF driven volume source with a 30kV triode accelerator. Improvement and characterisation work includes: Installation of a new “L” type RF matching unit, used to calculate the load on the RF generator. Use of the electron suppressing biased insert as a Langmuir probe under different beam extraction conditions. Measurement of the hydrogen Fulcher molecular spectrum, used to calculate gas temperature in the source. Beam optimisation through parameter scans, using copper target plate and visible cameras, with results compared with AXCEL-INP to provide beam current estimate. Modelling of the beam power density profile on the target plate using ANSYS to estimate beam power and provide another estimate of beam current. This work is described, and has allowed an estimation of the extracted beam current of approximately 6mA (4mA/cm2) at 3.5kW RF power and a source pressure of 0.6Pa.

  17. Flavonoids and dementia: an update.

    Science.gov (United States)

    Orhan, I E; Daglia, M; Nabavi, S F; Loizzo, M R; Sobarzo-Sánchez, E; Nabavi, S M

    2015-01-01

    Dementia is a strongly age-related syndrome due to cognitive decline that can be considered a typical example of the combination of physiological and pathological aging-associated changes occurring in old people; it ranges from intact cognition to mild cognitive impairment, which is an intermediate stage of cognitive deterioration, and dementia. The spread of this syndrome has induced to study and try to reduce dementia modifiable risk factors. They include insulin resistance and hyperinsulinaemia, high blood pressure, obesity, smoking, depression, cognitive inactivity or low educational attainment as well as physical inactivity and incorrect diet, which can be considered one of the most important factors. One emerging strategy to decrease the prevalence of mild cognitive impairment and dementia may be the use of nutritional interventions. In the last decade, prospective data have suggested that high fruit and vegetable intakes are related to improved cognitive functions and reduced risks of developing a neurodegenerative process. The protective effects against neurodegeneration could be in part due to the intake of flavonoids that have been associated with several health benefits such as antioxidant and anti-inflammatory activities, increased neuronal signaling, and improved metabolic functions. The present article is aimed at reviewing scientific studies that show the protective effects of flavonoid intake against mild cognitive impairment and dementia.

  18. Dynamic Data Updating Algorithm for Image Superresolution Reconstruction

    Institute of Scientific and Technical Information of China (English)

    TAN Bing; XU Qing; ZHANG Yan; XING Shuai

    2006-01-01

    A dynamic data updating algorithm for image superesolution is proposed. On the basis of Delaunay triangulation and its local updating property, this algorithm can update the changed region directly under the circumstances that only a part of the source images has been changed. For its high efficiency and adaptability, this algorithm can serve as a fast algorithm for image superesolution reconstruction.

  19. 76 FR 28194 - Proposed FOIA Fee Schedule Update

    Science.gov (United States)

    2011-05-16

    ... SAFETY BOARD 10 CFR Part 1703 Proposed FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety... (FOIA) Fee Schedule Update and solicits comments from interested organizations and individual members of... regulations, the Board's General Manager will update the FOIA Fee Schedule once every 12 months. Previous...

  20. 42 CFR 414.30 - Conversion factor update.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Conversion factor update. 414.30 Section 414.30... Practitioners § 414.30 Conversion factor update. Unless Congress acts in accordance with section 1848(d)(3) of the Act— (a) General rule. The CF update for a CY equals the Medicare Economic Index increased...

  1. 77 FR 32433 - Proposed FOIA Fee Schedule Update

    Science.gov (United States)

    2012-06-01

    ... NUCLEAR FACILITIES SAFETY BOARD 10 CFR Part 1703 Proposed FOIA Fee Schedule Update AGENCY: Defense Nuclear... Freedom of Information Act (FOIA) Fee Schedule Update and solicits comments from interested organizations...) of the Board's regulations, the Board's General Manager will update the FOIA Fee Schedule once...

  2. 10 CFR 474.5 - Review and Update

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Review and Update 474.5 Section 474.5 Energy DEPARTMENT OF...; PETROLEUM-EQUIVALENT FUEL ECONOMY CALCULATION § 474.5 Review and Update The Department will review Part 474 five years after the date of publication as a final rule to determine whether any updates...

  3. 75 FR 27228 - Proposed FOIA Fee Schedule Update

    Science.gov (United States)

    2010-05-14

    ... SAFETY BOARD 10 CFR Part 1703 Proposed FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety... (FOIA) Fee Schedule Update and solicits comments from interested organizations and individual members of... regulations, the Board's General Manager will update the FOIA Fee Schedule once every 12 months. Previous...

  4. 40 CFR 68.36 - Review and update.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Review and update. 68.36 Section 68.36... ACCIDENT PREVENTION PROVISIONS Hazard Assessment § 68.36 Review and update. (a) The owner or operator shall review and update the offsite consequence analyses at least once every five years. (b) If changes...

  5. Human-System Integration Scorecard Update to VB.Net

    Science.gov (United States)

    Sanders, Blaze D.

    2009-01-01

    The purpose of this project was to create Human-System Integration (HSI) scorecard software, which could be utilized to validate that human factors have been considered early in hardware/system specifications and design. The HSI scorecard is partially based upon the revised Human Rating Requirements (HRR) intended for NASA's Constellation program. This software scorecard will allow for quick appraisal of HSI factors, by using visual aids to highlight low and rapidly changing scores. This project consisted of creating a user-friendly Visual Basic program that could be easily distributed and updated, to and by fellow colleagues. Updating the Microsoft Word version of the HSI scorecard to a computer application will allow for the addition of useful features, improved easy of use, and decreased completion time for user. One significant addition is the ability to create Microsoft Excel graphs automatically from scorecard data, to allow for clear presentation of problematic areas. The purpose of this paper is to describe the rational and benefits of creating the HSI scorecard software, the problems and goals of project, and future work that could be done.

  6. What every gynecologist should know about male infertility: an update.

    Science.gov (United States)

    Esteves, Sandro C; Hamada, Alaa; Kondray, Victor; Pitchika, Aruna; Agarwal, Ashok

    2012-07-01

    Our article reviews the evolving concepts in the field of male infertility for gynecologists and other health professionals involved in the care of men and women experiencing difficulty in having a child. The increased knowledge will help in the better management and treatment of infertile couples. Review of literature through Pubmed, Science Direct, Online Library. Gynecologists are often the first healthcare providers to assess an infertile couple. Because half of all infertility problems stem from male factors, it is crucial for the gynecologist to remain updated on the main conditions that cause male infertility as well as current diagnostic tools and treatment options, including conventional strategies and assisted reproductive techniques. Extraordinary advances have been achieved in the field of male infertility over the past several years and many old concepts are now challenged. Therefore, it is imperative that male infertility physicians should update the gynecologists about the recent advances in the work-up of infertile men in terms of diagnosis and management. Such convention will help improve the standards of care for the infertile couple and enhance the cooperation between male and female reproductive endocrinologists.

  7. PF-WFS Shell Inspection Update December 2016

    Energy Technology Data Exchange (ETDEWEB)

    Vigil, Anthony Eugene [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Ledoux, Reina Rebecca [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Gonzales, Antonio R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Montano, Joshua Daniel [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Savage, Lowell Curtis [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Randles, Wayne Alfred [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-01-26

    Since the last project update in FY16:Q2, PF-WFS personnel have advanced in understanding of shell inspection on Coordinate Measuring Machines {CMM} and refined the PF-WFS process to the point it was decided to convert shell inspection from the Sheffield #1 gage to Lietz CM Ms. As a part of introspection on the quality of this process many sets of data have been reviewed and analyzed. This analysis included Sheffield to CMM comparisons, CMM inspection repeatability, fixturing differences, quality check development, probing approach changes. This update report will touch on these improvements that have built the confidence in this process to mainstream it inspecting shells. In addition to the CMM programming advancements, the continuation in refinement of input and outputs for the CMM program has created an archiving scheme, input spline files, an output metafile, and inspection report package. This project will continue to mature. Part designs may require program modifications to accommodate "new to this process" part designs. Technology limitations tied to security and performance are requiring possible changes to computer configurations to support an automated process.

  8. Update in cardiology: vascular risk and cardiac rehabilitation.

    Science.gov (United States)

    Galve, Enrique; Cordero, Alberto; Bertomeu-Martínez, Vicente; Fácila, Lorenzo; Mazón, Pilar; Alegría, Eduardo; Fernández de Bobadilla, Jaime; García-Porrero, Esteban; Martínez-Sellés, Manuel; González-Juanatey, José Ramón

    2015-02-01

    As in other fields, understanding of vascular risk and rehabilitation is constantly improving. The present review of recent epidemiological update shows how far we are from achieving good risk factor control: in diet and nutrition, where unhealthy and excessive societal consumption is clearly increasing the prevalence of obesity; in exercise, where it is difficult to find a balance between benefit and risk, despite systemization efforts; in smoking, where developments center on programs and policies, with the electronic cigarette seeming more like a problem than a solution; in lipids, where the transatlantic debate between guidelines is becoming a paradigm of the divergence of views in this extensively studied area; in hypertension, where a nonpharmacological alternative (renal denervation) has been undermined by the SYMPLICITY HTN-3 setback, forcing a deep reassessment; in diabetes mellitus, where the new dipeptidyl peptidase-4 and sodium-glucose cotransporter type 2 inhibitors and glucagon like peptide 1 analogues have contributed much new information and a glimpse of the future of diabetes treatment, and in cardiac rehabilitation, which continues to benefit from new information and communication technologies and where clinical benefit is not hindered by advanced diseases, such as heart failure. Our summary concludes with the update in elderly patients, whose treatment criteria are extrapolated from those of younger patients, with the present review clearly indicating that should not be the case.

  9. Strategy updating rules and strategy distributions in dynamical multiagent systems

    Science.gov (United States)

    Hod, Shahar; Nakar, Ehud

    2003-08-01

    In the evolutionary version of the minority game, agents update their strategies (gene value p) in order to improve their performance. Motivated by the recent intriguing results obtained for prize-to-fine ratios, which are smaller than unity, we explore the system’s dynamics with a strategy updating rule of the form p→p±δp (0⩽p⩽1). We find that the strategy distribution depends strongly on the values of the prize-to-fine ratio R, the length scale δp, and the type of boundary condition used. We show that these parameters determine the amplitude and the frequency of the temporal oscillations observed in the gene space. These regular oscillations are shown to be the main factors which determine the strategy distribution of the population. In addition, we find that the agents characterized by p=1/2 (a coin-tossing strategy) have the best chances of survival at asymptotically long times, regardless of the value of δp and the boundary conditions used.

  10. Updating river bathymetry with multiple data sources using kriging

    Science.gov (United States)

    Jha, S. K.; Bailey, B.; Minsker, B. S.; Cash, R. W.; Best, J. L.

    2011-12-01

    update the estimated variance structure; (iii) use the updated variance structure to predict the bathymetry; and (iv) validate the model prediction using Survey 3 measurements. For step (i), a geostatistical model was developed using ordinary and Bayesian kriging with the geoR package within R statistical software. The results obtained from both approaches were less than 2% different from each other, hence ordinary kriging was used for further analysis as it is less computationally demanding. For steps (ii) and (iii), the algorithm proposed by Barnes and Watson (1992) is used for updating kriging variances and depth estimates. The model was used to predict the depth at 2,000 randomly sampled points among the Survey 3 measurement locations. The average normalized RMSE of the updated bathymetry was around 0.15 with respect to the Survey 3 measurements. The developed method holds promise for improving bathymetry estimates at low cost, but more boat passes may be needed to bring errors to sufficiently low levels.

  11. Update on Postsurgical Scar Management.

    Science.gov (United States)

    Commander, Sarah Jane; Chamata, Edward; Cox, Joshua; Dickey, Ryan M; Lee, Edward I

    2016-08-01

    Postoperative scar appearance is often a significant concern among patients, with many seeking advice from their surgeons regarding scar minimization. Numerous products are available that claim to decrease postoperative scar formation and improve wound healing. These products attempt to create an ideal environment for wound healing by targeting the three phases of wound healing: inflammation, proliferation, and remodeling. With that said, preoperative interventions, such as lifestyle modifications and optimization of medical comorbidities, and intraoperative interventions, such as adherence to meticulous operative techniques, are equally important for ideal scarring. In this article, the authors review the available options in postoperative scar management, addressing the benefits of multimodal perioperative intervention. Although numerous treatments exist, no single modality has been proven superior over others. Therefore, each patient should receive a personalized treatment regimen to optimize scar management.

  12. Update in restless legs syndrome

    Science.gov (United States)

    Salas, Rachel E.; Gamaldo, Charlene E.; Allen, Richard P.

    2016-01-01

    Purpose of review Although restless legs syndrome (RLS) is a disorder recognized in the medical literature since the 17th century, there have only recently been significant clinical and scientific advances in diagnosis, epidemiology and understanding the disorder, mainly due to the advent of dopaminergic treatment. Recent findings Recent discoveries have uncovered the iron–dopamine connection in RLS and the basic dopaminergic pathology related to the RLS symptoms. These have led to new understanding of the morbidity of RLS and the many conditions associated with RLS, which have also supported new approaches to treatment. These developments are each briefly described here. Summary Although there has been progress in understanding, diagnosing and treating RLS, it remains an underdiagnosed and undertreated condition severely impairing functioning of patients with moderate-to-severe disease. Much work is needed to improve on current, as well as other novel therapies. PMID:20581683

  13. Emerging inhaled bronchodilators: an update.

    Science.gov (United States)

    Cazzola, M; Matera, M G

    2009-09-01

    Bronchodilators remain central to the symptomatic management of chronic obstructive pulmonary disease and asthma, and, for this reason and also because the patent protection of many bronchodilators has expired, several companies have reinitiated research into the field. The only limits set for the development of a long-lasting bronchodilator with a new product profile are medical needs and marketing opportunities. The incorporation of once-daily dose administration is an important strategy for improving adherence and is a regimen preferred by most patients. A variety of beta(2)-agonists and antimuscarinic agents with longer half-lives and inhalers containing a combination of several classes of long-acting bronchodilator are currently under development. The present article reviews all of the most important compounds under development, describing what has been done and discussing their genuine advantage.

  14. Current Update in Asian Rhinoplasty

    Directory of Open Access Journals (Sweden)

    Clyde H. Ishii, MD, FACS

    2014-04-01

    Full Text Available Summary: There has been a tremendous growth of cosmetic surgery among Asians worldwide. Rhinoplasty is second only to blepharoplasty in terms of popularity among Asians regarding cosmetic surgical procedures. Most Asians seek to improve their appearance while maintaining the essential features of their ethnicity. There are considerable ethnic nasal and facial variations in this population alone. Successful rhinoplasty in Asians must take into account underlying anatomic differences between Asians and whites. Due to ethnic variations, cultural differences, and occasional language barriers, careful preoperative counseling is necessary to align the patient’s expectations with the limitations of the procedure. This article will review the many facets of Asian rhinoplasty as it is practiced today.

  15. Enhancement of ELDA Tracker Based on CNN Features and Adaptive Model Update.

    Science.gov (United States)

    Gao, Changxin; Shi, Huizhang; Yu, Jin-Gang; Sang, Nong

    2016-04-15

    Appearance representation and the observation model are the most important components in designing a robust visual tracking algorithm for video-based sensors. Additionally, the exemplar-based linear discriminant analysis (ELDA) model has shown good performance in object tracking. Based on that, we improve the ELDA tracking algorithm by deep convolutional neural network (CNN) features and adaptive model update. Deep CNN features have been successfully used in various computer vision tasks. Extracting CNN features on all of the candidate windows is time consuming. To address this problem, a two-step CNN feature extraction method is proposed by separately computing convolutional layers and fully-connected layers. Due to the strong discriminative ability of CNN features and the exemplar-based model, we update both object and background models to improve their adaptivity and to deal with the tradeoff between discriminative ability and adaptivity. An object updating method is proposed to select the "good" models (detectors), which are quite discriminative and uncorrelated to other selected models. Meanwhile, we build the background model as a Gaussian mixture model (GMM) to adapt to complex scenes, which is initialized offline and updated online. The proposed tracker is evaluated on a benchmark dataset of 50 video sequences with various challenges. It achieves the best overall performance among the compared state-of-the-art trackers, which demonstrates the effectiveness and robustness of our tracking algorithm.

  16. Enhancement of ELDA Tracker Based on CNN Features and Adaptive Model Update

    Directory of Open Access Journals (Sweden)

    Changxin Gao

    2016-04-01

    Full Text Available Appearance representation and the observation model are the most important components in designing a robust visual tracking algorithm for video-based sensors. Additionally, the exemplar-based linear discriminant analysis (ELDA model has shown good performance in object tracking. Based on that, we improve the ELDA tracking algorithm by deep convolutional neural network (CNN features and adaptive model update. Deep CNN features have been successfully used in various computer vision tasks. Extracting CNN features on all of the candidate windows is time consuming. To address this problem, a two-step CNN feature extraction method is proposed by separately computing convolutional layers and fully-connected layers. Due to the strong discriminative ability of CNN features and the exemplar-based model, we update both object and background models to improve their adaptivity and to deal with the tradeoff between discriminative ability and adaptivity. An object updating method is proposed to select the “good” models (detectors, which are quite discriminative and uncorrelated to other selected models. Meanwhile, we build the background model as a Gaussian mixture model (GMM to adapt to complex scenes, which is initialized offline and updated online. The proposed tracker is evaluated on a benchmark dataset of 50 video sequences with various challenges. It achieves the best overall performance among the compared state-of-the-art trackers, which demonstrates the effectiveness and robustness of our tracking algorithm.

  17. Molecular breast imaging. An update; Molekulare Brustbildgebung. Ein Update

    Energy Technology Data Exchange (ETDEWEB)

    Pinker, K.; Helbich, T.H.; Magometschnigg, H.; Baltzer, P. [Medizinische Universitaet Wien, Abteilung fuer Molekulare Bildgebung, Universitaetsklinik fuer Radiologie und Nuklearmedizin, Wien (Austria); Fueger, B. [Medizinische Universitaet Wien, Abteilung fuer Molekulare Bildgebung, Universitaetsklinik fuer Radiologie und Nuklearmedizin, Wien (Austria); Medizinische Universitaet Wien, Abteilung fuer Nuklearmedizin, Universitaetsklinik fuer Radiologie und Nuklearmedizin, Wien (Austria)

    2014-03-15

    The aim of molecular imaging is to visualize and quantify biological, physiological and pathological processes at cellular and molecular levels. Molecular imaging using various techniques has recently become established in breast imaging. Currently molecular imaging techniques comprise multiparametric magnetic resonance imaging (MRI) using dynamic contrast-enhanced MRI (DCE-MRI), diffusion-weighted imaging (DWI), proton MR spectroscopy ({sup 1}H-MRSI), nuclear imaging by breast-specific gamma imaging (BSGI), positron emission tomography (PET) and positron emission mammography (PEM) and combinations of techniques (e.g. PET-CT and multiparametric PET-MRI). Recently, novel techniques for molecular imaging of breast tumors, such as sodium imaging ({sup 23}Na-MRI), phosphorus spectroscopy ({sup 31}P-MRSI) and hyperpolarized MRI as well as specific radiotracers have been developed and are currently under investigation. It can be expected that molecular imaging of breast tumors will enable a simultaneous assessment of the multiple metabolic and molecular processes involved in cancer development and thus an improved detection, characterization, staging and monitoring of response to treatment will become possible. (orig.) [German] Die molekulare Bildgebung zielt auf die Darstellung, Beschreibung und Quantifizierung biologischer, physiologischer und pathologischer Prozesse auf zellulaerer und molekularer Ebene ab. In den letzten Jahren hat sich die molekulare Bildgebung mit ihren verschiedenen Modalitaeten in der Brustdiagnostik etabliert. Die molekularen Brustbildgebung umfasst derzeit die multiparametrische(MP)-MRT mit funktioneller und morphologischer kontrastmittelverstaerkter MRT (KM-MRT), molekularer diffusionsgewichteter Bildgebung (''diffusion-weighted imaging'', DWI) und metabolischer Protonenspektroskopie ({sup 1}H-MRSI) sowie nuklearmedizinische Verfahren (brustspezifische Gammakamerabildgebung [BSGI], Positronenemissionstomographie [PET], PET

  18. Oncogenes in melanoma: an update.

    Science.gov (United States)

    Kunz, Manfred

    2014-01-01

    Melanoma is a highly aggressive tumour with poor prognosis in the metastatic stage. BRAF, NRAS, and KIT are three well-known oncogenes involved in melanoma pathogenesis. Targeting of mutated BRAF kinase has recently been shown to significantly improve overall survival of metastatic melanoma patients, underscoring the particular role of this oncogene in melanoma biology. However, recurrences regularly occur within several months, which supposedly involve further oncogenes. Moreover, oncogenic driver mutations have not been described for up to 30% of all melanomas. In order to obtain a more complete picture of the mutational landscape of melanoma, more recent studies used high-throughput DNA sequencing technologies. A number of new oncogene candidates such as MAPK1/2, ERBB4, GRIN2A, GRM3, RAC1, and PREX2 were identified. Their particular role in melanoma biology is currently under investigation. Evidence for the functional relevance of some of these new oncogene candidates has been provided in in vitro and in vivo experiments. However, these findings await further validation in clinical studies. This review provides an overview on well-known melanoma oncogenes and new oncogene candidates, based on recent high-throughput sequencing studies. The list of genes discussed herein is of course not complete but highlights some of the most significant of recent findings in this area. The new candidates may support more individualized treatment approaches for metastatic melanoma patients in the future.

  19. [Critical limb ischemia--update].

    Science.gov (United States)

    Melamed, Eitan; Kotyba, Baydousi; Galili, Offer; Karmeli, Ron

    2010-12-01

    Critical limb ischemia (CLI) is the most severe manifestation of peripheral artery occlusive disease. Without timely diagnosis and revascularization, patients with CLI are at risk of devastating complications including loss of limb and life. Therapeutic goals in treating patients with CLI include reducing cardiovascular risk factors, relieving ischemic pain, heating ulcers, preventing major amputation, improving quality of life and increasing survival. These aims may be achieved through medical therapy, revascularization or amputation. The past decade has seen substantial growth in endovascular therapies and options now exist for treating long segment occlusive disease, but surgical bypass may still yield more durable results. Patients who are younger, more active, and at low risk for surgery, may have better outcomes undergoing an operation. This is also indicated for endovascular failures, which may include technical failures or late occlusions after stents or other procedures. In contrast, frail patients with a limited life expectancy may experience better outcomes with endovascular therapy. For patients who are non-ambulatory, demented, or unfit to undergo revascularization, an amputation should be considered.

  20. Manitoba Williston Basin activity update

    Energy Technology Data Exchange (ETDEWEB)

    Fox, J. [Manitoba Industry, Trade and Mines, Winnipeg, MB (Canada)

    2003-07-01

    This presentation described the drilling activity in Manitoba from 1998 to 2002 with particular emphasis on horizontal well drilling and production by geologic formation, including the Bakken, Lodgepole and the Lower Amaranth Formations. A total of 97 wells were drilled in Manitoba in 2002. The most active drillers were EOG Resources Canada with a total of 34 wells. Tundra Oil and Gas was close behind with 28 wells, followed by Chevron Canada Resources with 21 wells. Horizontal drilling had a major impact in Manitoba between 1998-2002, representing 30 per cent of drilling activity focused on the Waskada, Virden and Daly fields. Expansion activity throughout the province contributed to the overall increase in oil production for four consecutive years. Annual production reached 650.7 10{sup 3}m{sup 3} in 2001. Manitoba's top 5 producers are Chevron Canada Resources, Tundra Oil and Gas, EOG Resources Canada, Canadian Natural Resources and NCE Petrofund. Together, they account for 89 per cent of Manitoba's production. This paper also described some of the initiatives that Manitoba's Department of Industry, Trade and Mines has taken to improve oil and gas regulations through proposed amendments to the Oil and Gas Act, a review of the Manitoba Drilling Incentive Program, battery re-permitting, and a strategy for managing orphaned wells. 3 figs.

  1. Radioelements on Vesta: An Update

    Science.gov (United States)

    Prettyman, T. H.; Yamashita, N.; Reedy, R. C.; McSween, H. Y.; Mittlefehldt, D. W.

    2014-01-01

    The main-belt asteroid 4 Vesta is the putative parent body of the howardite, eucrite, and diogenite (HED) meteorites. Because these achondrites have similar petrology, geochemistry, chronology, and O-isotope compositions, it is thought that most HEDs originated from a single parent body. The connection to Vesta is supported by a close spectroscopic match between Vesta and the HEDs and a credible mechanism for their delivery to Earth. Studies of the HEDs show that Vesta underwent igneous differentiation, forming a Fe-rich core, ultramafic mantle, and basaltic crust. Here we present the results of peak analyses applied to a gamma ray difference spectrum to determine the absolute abundances of K and Th. Data are compared to meteorite whole-rock compositions and other inner solar system bodies. The results, while preliminary, represent our present best estimates for these elements. Because the element signatures are near detection limits and not fully resolved, further analysis (e.g. using spectral unmixing) will be required for improved accuracy and to characterize systematic errors.

  2. Failure to thrive: an update.

    Science.gov (United States)

    Cole, Sarah Z; Lanham, Jason S

    2011-04-01

    Failure to thrive in childhood is a state of undernutrition due to inadequate caloric intake, inadequate caloric absorption, or excessive caloric expenditure. In the United States, it is seen in 5 to 10 percent of children in primary care settings. Although failure to thrive is often defined as a weight for age that falls below the 5th percentile on multiple occasions or weight deceleration that crosses two major percentile lines on a growth chart, use of any single indicator has a low positive predictive value. Most cases of failure to thrive involve inadequate caloric intake caused by behavioral or psychosocial issues. The most important part of the outpatient evaluation is obtaining an accurate account of a child's eating habits and caloric intake. Routine laboratory testing rarely identifies a cause and is not generally recommended. Reasons to hospitalize a child for further evaluation include failure of outpatient management, suspicion of abuse or neglect, or severe psychosocial impairment of the caregiver. A multidisciplinary approach to treatment, including home nursing visits and nutritional counseling, has been shown to improve weight gain, parent-child relationships, and cognitive development. The long-term effects of failure to thrive on cognitive development and future academic performance are unclear.

  3. Brain MR Spectroscopy: An Update

    Directory of Open Access Journals (Sweden)

    Amir Arsalan Zamani

    2011-05-01

    Full Text Available Advances in brain MR spectroscopy can be classified in"nthree different fields: MR spectroscopy with a higher"nstrength scanner, integration of MR spectroscopy with"nother imaging techniques in the diagnosis of brain"ntumors, and the topic of MRS in psychiatric diseases."nMRS with a higher strength magnet: The theoretical"nadvantage of a 3T magnet over a 1.5T magnet is an"nexpected two fold increase in signal to noise ratio. In"nIran J Radiol 2011, 8 (Supp.1 S63"nfact because of other factors (increased susceptibility"neffects, difficulty in achieving good shimming, shorter"nT1 values and the SAR issue this improved signal/"nnoise ratio is less than a factor of two. Nevertheless,"nin MRS with a higher strength magnet, there is a"ndefinite improved spectral resolution. This under"nproper condition allows a better separation of peaks"nthat were close together (or even superimposed on one"nanother on a 1.5T magnet. Imaging lactate becomes"nmore challenging as we will see."nAs the MRS has becomes better refined and its"ncapabilities better understood, it has found its way"ninto multiple imaging algorithms of brain tumors. One"nof the best known of these begins by dividing lesions"non the basis of whether they enhance or not and then,"nduring the rest of the algorithm uses MRS results in"nconjunction with DWI, and perfusion imaging toward"na more accurate diagnosis. The accuracy of these"nalgorithms is being tested but the results so far have"nbeen promising. The role of MRS in these algorithms"nis on differentiation of non-enhancing lesions (nonneoplastic"nvs. neoplastic and in the differentiation"nof high grade neoplasm into primary and metastatic"ndisease."nMRS in psychiatric disease: MR imaging in general"nand MRS in particular, have been used in psychiatry"nfor almost 30 years now. As imaging has evolved and"nimproved it has become more and more clear that"npsychiatric disease, like organic disease, has its own"nneuropathology. Although

  4. The AGTSR consortium: An update

    Energy Technology Data Exchange (ETDEWEB)

    Fant, D.B.; Golan, L.P. [Clemson Univ., SC (United States)

    1995-10-01

    The Advanced Gas Turbine Systems Research (AGTSR) program is a collaborative University-Industry R&D Consortium that is managed and administered by the South Carolina Energy R&D Center. AGTSR is a nationwide consortium dedicated to advancing land-based gas turbine systems for improving future power generation capability. It directly supports the technology-research arm of the ATS program and targets industry-defined research needs in the areas of combustion, heat transfer, materials, aerodynamics, controls, alternative fuels, and advanced cycles. The consortium is organized to enhance U.S. competitiveness through close collaboration with universities, government, and industry at the R&D level. AGTSR is just finishing its third year of operation and is sponsored by the U.S. DOE - Morgantown Energy Technology Center. The program is scheduled to continue past the year 2000. At present, there are 78 performing member universities representing 36 states, and six cost-sharing U.S. gas turbine corporations. Three RFP`s have been announced and the fourth RFP is expected to be released in December, 1995. There are 31 research subcontracts underway at performing member universities. AGTSR has also organized three workshops, two in combustion and one in heat transfer. A materials workshop is in planning and is scheduled for February, 1996. An industrial internship program was initiated this past summer, with one intern positioned at each of the sponsoring companies. The AGTSR consortium nurtures close industry-university-government collaboration to enhance synergism and the transition of research results, accelerate and promote evolutionary-revolutionary R&D, and strives to keep a prominent U.S. industry strong and on top well into the 21st century. This paper will present the objectives and benefits of the AGTSR program, progress achieved to date, and future planned activity in fiscal year 1996.

  5. [Intensive care medicine -- update 2005].

    Science.gov (United States)

    Flohé, S; Lendemans, S; Schmitz, D; Waydhas, C

    2006-06-01

    This manuscript gives a review about important studies addressing problems in intensive care medicine that have been published in journals focussing on critical care medicine and surgery in 2005. Only clinical studies are included in this review, mostly meta-analyses, randomized controlled trials and a few important or interesting observational studies. In addition to describing major results a critical appraisal of each study is undertaken, which, however, is neither comprehensive nor complete. It is merely intended to address some important aspects for the reader who should be stimulated to go deeper into one or the other topic or study. The publication of the new CPR-guidelines of the American Heart Association and the European Resuscitation Council as well as the newly developed SAPS III score to predict intensive care unit outcome are among the outstanding topics. Several randomized trials and meta-analyses deal with aspects of drug therapy of septic patients. Some important and relevant findings have been reported with respect to the efficiency of the open-lung concept, non-invasive ventilation, the use of heat and moisture exchanger filters compared to active humidifiers and of closed systems for endotracheal suctioning. The role of immuno-nutrition in adults and children as well as of early enteral nutrition can be defined more clearly. Whether corticosteroids should be used in the treatment of severe traumatic brain injury can be definitely answered now. There are some new insights reported into the management of patients infected or contaminated with MRSA in the intensive care unit. Last but not least an impressive study shows that not only the newest therapeutic developments but the stringent use of the already known treatment options may result in dramatic improvements of patient outcome.

  6. Update on Primary Biliary Cirrhosis

    Directory of Open Access Journals (Sweden)

    Jenny Heathcote

    2000-01-01

    Full Text Available The diagnosis of primary biliary cirrhosis (PBC is most often made in the asymptomatic phase, sometimes before the development of abnormal liver biochemistry. The antimitochondrial antibody remains the predominant hallmark, although not all patients test positive, even when the most sensitive techniques are used. The etiology of PBC remains elusive; studies suggest that the interlobular bile duct destruction is immune based, and associated autoimmune diseases are common. There are no surrogate markers that predict outcome in asymptomatic patients, whose chance of survival is less than that of age- and sex-matched populations but much better than the median survival of eight years in patients with symptomatic PBC. Symptoms common in this disease are fatigue, pruritus and xanthelasma, as well as complications of portal hypertension and osteoporosis. Treatment includes symptomatic and preventive measures, as well as specific therapeutic measures. Immunosuppressive therapy has yielded disappointing results in the long term management of PBC, and the only therapy shown to improve survival is the hydrophobic dihydroxy bile acid ursodeoxycholic acid. Treatment at a dose of 13 to 15 mg/kg/day is optimal, given in separate doses or as a single dose at least 4 h from giving the oral anion exchange resin cholestyramine, which may be used to control pruritus. However, liver transplantation remains the only cure for this disease, and the best postoperative survival is seen in patients whose serum bilirubin does not exceed 180 µmol/L at the time of liver transplantation. Recurrence takes place but is rarely symptomatic and does not deter from the benefits of transplantation.

  7. Update on pleural diseases - 2007

    Directory of Open Access Journals (Sweden)

    Bishay Ayman

    2007-01-01

    Full Text Available Background : New information is available on pleural diseases. The authors selected articles to make recommendations on diagnostic and treatment aspects of pleural diseases. Materials and Methods: Eleven articles published in the English language between 2004 and 2007 were chosen. The basis of selection of the articles was the impact on daily practice, change in prior thinking of a disease process or specific treatment modality, as well as proper design and execution of the study. 5-amino-laevulinic acid with fluorescent light combined with white light may allow further diagnostic yield in undiagnosed pleural disease. FDG-PET may allow prognostication of patients with pleural tumors. Utilizing ultrasound by trained Emergency Department physicians is a rapid and effective technique to evaluate non-traumatic pleural effusions in symptomatic patients. Serum osteopontin levels may distinguish patients exposed to asbestos with benign disease from those with pleural mesothelioma. Administration of streptokinase in patients with empyema does not need for surgical drainage, length of hospital stay, or mortality as compared to conventional treatment with chest tube drainage and intravenous antibiotics. Silver nitrate may be an alternative agent to talc for producing pleurodesis. Routine use of graded talc (50% particles greater than 25 microns is recommended to reduce the morbidity associated with talc pleurodesis. Study design does not permit us to conclude that aspiration of spontaneous pneumothorax is as effective as chest tube drainage. Pleural catheter may prove to be an important palliative modality in treating debilitated patients or patients with trapped lung who show symptomatic improvement with drainage; however, at the present time, these catheters cannot be considered a first line treatment option for patients with malignant pleural effusion. One of the studies reviewed showed no significant difference in tract metastasis in patients with

  8. Progress Toward an Updated National Solar Radiation Data Base

    Energy Technology Data Exchange (ETDEWEB)

    Wilcox, S.; Anderberg, M.; George, R.; Marion, W.; Myers, D.; Renne, D.; Beckman, W.; DeGaetano, A.; Gueymard, C.; Perez, R.; Plantico, M.; Stackhouse, P.; Vignola, F.

    2005-01-01

    Progress is reported on an updated National Solar Radiation Database (NSRDB). Focus on this year's work was on preparing a test-year database for evaluating several solar radiation models that could be used to replace the METSTAT model used in the original 1961-1990 NSRDB. That model is no longer compatible with cloud observations reported by the National Weather Service. We have also included a satellite-based model that will increase the spatial resolution of solar radiation for GIS or mapping applications. Work also included development of improved estimates for aerosols, water vapor, and ozone. High-quality solar measurements were obtained for 33 sites near National Weather Service stations, and model runs were completed for test years 1999 and 2000.

  9. Update on Radioactive Waste Management in the UK

    Energy Technology Data Exchange (ETDEWEB)

    Dalton, John; McCall, Ann

    2003-02-24

    This paper provides a brief background to the current position in the United Kingdom (UK) and provides an update on the various developments and initiatives within the field of radioactive waste management that have been taking place during 2002/03. These include: The UK Government's Department of Trade and Industry (DTi) review of UK energy policy; The UK Government's (Department of Environment, Food and Rural Affairs (Defra) and Devolved Administrations*) consultation program; The UK Government's DTi White Paper, 'Managing the Nuclear Legacy: A Strategy for Action'; Proposals for improved regulation of Intermediate Level Waste (ILW) conditioning and packaging. These various initiatives relate, in Nirex's opinion, to the three sectors of the industry and this paper will provide a comment on these initiatives in light of the lessons that Nirex has learnt from past events and suggest some conclusions for the future.

  10. Rebuild America Partner Update, January--February 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-01-01

    Rebuild America Partner Update, the bimonthly newsletter about the Rebuild America community, covers partnership activities, industry trends, and program news. Rebuild America is a network of community partnerships--made up of local governments and businesses--that save money by saving energy. These voluntary partnerships, working with the US Department of Energy, choose the best ways to improve the energy efficiency of commercial, government and apartment buildings. Rebuild America supports them with business and technical tools and customized assistance. By the year 2003, 250 Rebuild America partnerships will be involved in over 2 billion square feet of building renovations, which will save $650 million every year in energy costs, generate $3 billion in private community investment, create 26,000 new private sector jobs, and reduce air pollution by 1.6 million tons of carbon dioxide a year.

  11. [Updated detection of the function of sperm plasma membrane].

    Science.gov (United States)

    Zhou, Xin; Xia, Xin-Yi; Huang, Yu-Feng

    2010-08-01

    The sperm plasma membrane is rich in polyunsaturated fatty acids and a variety of proteins, and its function is associated with sperm capacitation, acrosome reaction and sperm-egg fusion. Sperm fertilizability can be predicted by detecting the function of the sperm plasma membrane, which is performed mainly with the following five techniques: sperm hypoosmotic swelling test, Eosin gamma water test, sperm membrane lipid peroxidation determination, seminal plasma superoxide dismutase determination, and flow cytometry. The evaluation of the function of sperm plasma membrane can be applied in detecting semen quality, selecting semen centrifugation, assessing the quality and fertilizability of sex-sorted sperm, improving cryopreservation, and guiding the optimization of intracytoplasmic sperm injection. This review presents an update on the principles, methods and steps of the detection of sperm plasma membrane function, as well as an overview of its status quo and application.

  12. Sustainability in the Power Sector. 2010 Update. The Netherlands

    Energy Technology Data Exchange (ETDEWEB)

    Steinweg, T.; Ten Kate, A.; Racz, K.

    2010-11-15

    This 2010 series of power company and thematic fact sheets aims to raise public awareness about sustainability issues in the electricity sector and to improve the sustainability of power companies operating in the Netherlands. The fact sheet series investigates the companies' performance on incorporating renewable energy sources into their fuel mix for both generation and supply of electricity, and on their investments and future plans with respect to energy sources at both the Dutch and European level. The 2010 fact sheet series is the annual update that is going into its fourth year, and builds on the work from previous years (available at www.somo.nl), but includes a slightly different range of companies due to a number of recent and pending mergers and acquisitions among power companies with operations in the Netherlands.

  13. Update of the androgen receptor gene mutations database.

    Science.gov (United States)

    Gottlieb, B; Beitel, L K; Lumbroso, R; Pinsky, L; Trifiro, M

    1999-01-01

    The current version of the androgen receptor (AR) gene mutations database is described. The total number of reported mutations has risen from 309 to 374 during the past year. We have expanded the database by adding information on AR-interacting proteins; and we have improved the database by identifying those mutation entries that have been updated. Mutations of unknown significance have now been reported in both the 5' and 3' untranslated regions of the AR gene, and in individuals who are somatic mosaics constitutionally. In addition, single nucleotide polymorphisms, including silent mutations, have been discovered in normal individuals and in individuals with male infertility. A mutation hotspot associated with prostatic cancer has been identified in exon 5. The database is available on the internet (http://www.mcgill.ca/androgendb/), from EMBL-European Bioinformatics Institute (ftp.ebi.ac.uk/pub/databases/androgen), or as a Macintosh FilemakerPro or Word file (MC33@musica.mcgill.ca).

  14. Edible oil structuring: an overview and recent updates.

    Science.gov (United States)

    Patel, Ashok R; Dewettinck, Koen

    2016-01-01

    In recent years, research dealing with edible oil structuring has received considerable interest from scientific community working in the area of food formulation. Much of this interest is linked to the possibility of using structured oil in development of newer product formats with improved nutritional profile (trans fat-free, low in saturated fats and high in mono and/or poly unsaturated fatty acids). In addition to the obvious industrial need of finding the alternative formulation approach, the interesting properties of structured systems (particularly, oleogels) also makes them a fascinating subject for fundamental studies. In this paper, we attempt to give a comprehensive and concise overview of the field of oil structuring with special emphasis on the updates from recent years. Specifically, several categories of food-grade oleogelators and their potential food applications are summarized with typical examples along with a discussion on the general principles and unresolved challenges related to this emerging area.

  15. FEM Updating of Tall Buildings using Ambient Vibration Data

    DEFF Research Database (Denmark)

    Ventura, C. E.; Lord, J. F.; Turek, M.;

    2005-01-01

    to develop reliable finite element models of large civil engineering structures. A fifteen story and a forty-eight story reinforced concrete buildings are used as case studies for this purpose. The dynamic characteristics of interest for this study were the first few lateral and torsional natural frequencies...... and the corresponding mode shapes. The degree of torsional coupling between the modes was also investigated. The modal identification results obtained from ambient vibration measurements of each building were used to update a finite element model of the structure. The starting model of each structure was developed from...... the information provided in the design documentation of the building. Different parameters of the model were then modified using an automated procedure to improve the correlation between measured and calculated modal parameters. Careful attention was placed to the selection of the parameters to be modified...

  16. The use of nanoparticles in electroanalysis: an updated review.

    Science.gov (United States)

    Campbell, Fallyn W; Compton, Richard G

    2010-01-01

    The use of nanoparticles in electroanalysis is an area of research which is continually expanding. A wealth of research is available discussing the synthesis, characterization and application of nanoparticles. The unique properties of nanoparticulate materials (e.g. enhanced mass transport, high surface area, improved signal-to-noise ratio) can often be advantageous in electroanalytical techniques. The aim of this paper is to provide an updated overview of the work in this field. In this review we have concentrated on the advances with regards to silver, gold, platinum, palladium, ruthenium, copper and nickel. The synthesis, characterization and practical application of these materials are discussed. We have also identified the conditions under which each metal is likely to be stable, which is likely to be a useful tool for those practising in the field. Furthermore, we have provided a theoretical overview of advances in the theoretical modelling and simulation of nanoparticle behaviour.

  17. State Energy Price System: 1982 update

    Energy Technology Data Exchange (ETDEWEB)

    Imhoff, K.L.; Fang, J.M.

    1984-10-01

    The State Energy Price System (STEPS) contains estimates of energy prices for ten major fuels (electricity, natural gas, metallurgical coal, steam coal, distillate, motor gasoline, diesel, kerosene/jet fuel, residual fuel, and liquefied petroleum gas), by major end-use sectors (residential, commercial, industrial, transportation, and electric utility), and by state through 1982. Both physical unit prices and prices per million Btu are included in STEPS. Major changes in STEPS data base for 1981 and 1982 are described. The most significant changes in procedures for the updates occur in the residential sector distillate series and the residential sector kerosene series. All physical unit and Btu prices are shown with three significant digits instead of with four significant digits as shown in the original documentation. Details of these and other changes are contained in this report, along with the updated data files. 31 references, 65 tables.

  18. Median sternotomy closure: review and update research

    Institute of Scientific and Technical Information of China (English)

    Hua Kun; Yang Xiubin

    2009-01-01

    Cardiac surgery is a very common operation nowadays all over the world. Median stemotomy is a routine procedure required for cardiac access during open heart surgery. The complications of this procedure after the cardiac surgery range from 0.7% to 1.5% of all cases, and bear a high mortality rate if they occur. Every individual surgeon must pay great attention on every detail during the sternal closure. This article shows the details as to conventional information and updated progress on median sternotomy closure. The update contents involve in biomechanics, number of wires twists, biomaterial and so on.According to our experience, we recommend four peristernal single/double steel wires for sternal closure as our optimal choice.

  19. Temporal Difference Updating without a Learning Rate

    CERN Document Server

    Hutter, Marcus

    2008-01-01

    We derive an equation for temporal difference learning from statistical principles. Specifically, we start with the variational principle and then bootstrap to produce an updating rule for discounted state value estimates. The resulting equation is similar to the standard equation for temporal difference learning with eligibility traces, so called TD(lambda), however it lacks the parameter alpha that specifies the learning rate. In the place of this free parameter there is now an equation for the learning rate that is specific to each state transition. We experimentally test this new learning rule against TD(lambda) and find that it offers superior performance in various settings. Finally, we make some preliminary investigations into how to extend our new temporal difference algorithm to reinforcement learning. To do this we combine our update equation with both Watkins' Q(lambda) and Sarsa(lambda) and find that it again offers superior performance without a learning rate parameter.

  20. Uncertainty for Part Density Determination: An Update

    Energy Technology Data Exchange (ETDEWEB)

    Valdez, Mario Orlando [Los Alamos National Laboratory

    2016-12-14

    Accurate and precise density measurements by hydrostatic weighing requires the use of an analytical balance, configured with a suspension system, to both measure the weight of a part in water and in air. Additionally, the densities of these liquid media (water and air) must be precisely known for the part density determination. To validate the accuracy and precision of these measurements, uncertainty statements are required. The work in this report is a revision of an original report written more than a decade ago, specifically applying principles and guidelines suggested by the Guide to the Expression of Uncertainty in Measurement (GUM) for determining the part density uncertainty through sensitivity analysis. In this work, updated derivations are provided; an original example is revised with the updated derivations and appendix, provided solely to uncertainty evaluations using Monte Carlo techniques, specifically using the NIST Uncertainty Machine, as a viable alternative method.