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Sample records for air sacs add

  1. Sisters of the sinuses: cetacean air sacs.

    Science.gov (United States)

    Reidenberg, Joy S; Laitman, Jeffrey T

    2008-11-01

    This overview assesses some distinguishing features of the cetacean (whale, dolphin, porpoise) air sac system that may relate to the anatomy and function of the paranasal sinuses in terrestrial mammals. The cetacean respiratory tract has been modified through evolution to accommodate living in water. Lack of paranasal sinuses in modern cetaceans may be a diving adaptation. Bone-enclosed air chambers are detrimental, as their rigid walls may fracture during descent/ascent due to contracting/re-expanding air volumes. Flexible-walled "sinuses" (extracranial diverticula) are a logical adaptation to diving. Odontocetes (toothed whales) exhibit several pairs of paranasal air sacs. Although fossil evidence indicates that paranasal sinuses occur in archaeocetes (ancestors/relatives of living cetaceans), it is not known whether the paranasal sacs derive from these sinuses. Sac pigmentation indicates that they derived from invaginations of the integument. Unlike sinuses, paranasal sacs are not circumferentially enclosed in bone, and therefore can accommodate air volume changes that accompany diving pressure changes. Paired pterygoid sacs, located ventrally along the cetacean skull, connect the pharynx and middle ear cavities. Mysticetes (baleen whales) have a large midline laryngeal sac. Although cetacean air sacs do not appear to be homologous to paranasal sinuses, they may serve some analogous respiratory, vocal, or structural functions. For example, these sacs may participate in gas exchange, thermoregulation, resonance, and skeletal pneumatization. In addition, they may subserve unique aquatic functions, such as increasing inspiratory volume, mitigating pressure-induced volume change, air shunting to reduce respiratory dead space, and facilitating underwater sound production and transmission.

  2. Loss of air sacs improved hominin speech abilities

    NARCIS (Netherlands)

    B. de Boer

    2012-01-01

    In this paper, the acoustic-perceptual effects of air sacs are investigated. Using an adaptive hearing experiment, it is shown that air sacs reduce the perceptual effect of vowel-like articulations. Air sacs are a feature of the vocal tract of all great apes, except humans. Because the presence or a

  3. Evidence for avian intrathoracic air sacs in a new predatory dinosaur from Argentina.

    Directory of Open Access Journals (Sweden)

    Paul C Sereno

    Full Text Available BACKGROUND: Living birds possess a unique heterogeneous pulmonary system composed of a rigid, dorsally-anchored lung and several compliant air sacs that operate as bellows, driving inspired air through the lung. Evidence from the fossil record for the origin and evolution of this system is extremely limited, because lungs do not fossilize and because the bellow-like air sacs in living birds only rarely penetrate (pneumatize skeletal bone and thus leave a record of their presence. METHODOLOGY/PRINCIPAL FINDINGS: We describe a new predatory dinosaur from Upper Cretaceous rocks in Argentina, Aerosteon riocoloradensis gen. et sp. nov., that exhibits extreme pneumatization of skeletal bone, including pneumatic hollowing of the furcula and ilium. In living birds, these two bones are pneumatized by diverticulae of air sacs (clavicular, abdominal that are involved in pulmonary ventilation. We also describe several pneumatized gastralia ("stomach ribs", which suggest that diverticulae of the air sac system were present in surface tissues of the thorax. CONCLUSIONS/SIGNIFICANCE: We present a four-phase model for the evolution of avian air sacs and costosternal-driven lung ventilation based on the known fossil record of theropod dinosaurs and osteological correlates in extant birds: (1 Phase I-Elaboration of paraxial cervical air sacs in basal theropods no later than the earliest Late Triassic. (2 Phase II-Differentiation of avian ventilatory air sacs, including both cranial (clavicular air sac and caudal (abdominal air sac divisions, in basal tetanurans during the Jurassic. A heterogeneous respiratory tract with compliant air sacs, in turn, suggests the presence of rigid, dorsally attached lungs with flow-through ventilation. (3 Phase III-Evolution of a primitive costosternal pump in maniraptoriform theropods before the close of the Jurassic. (4 Phase IV-Evolution of an advanced costosternal pump in maniraptoran theropods before the close of the Jurassic

  4. Evidence for Avian Intrathoracic Air Sacs in a New Predatory Dinosaur from Argentina

    Science.gov (United States)

    Sereno, Paul C.; Martinez, Ricardo N.; Wilson, Jeffrey A.; Varricchio, David J.; Alcober, Oscar A.; Larsson, Hans C. E.

    2008-01-01

    Background Living birds possess a unique heterogeneous pulmonary system composed of a rigid, dorsally-anchored lung and several compliant air sacs that operate as bellows, driving inspired air through the lung. Evidence from the fossil record for the origin and evolution of this system is extremely limited, because lungs do not fossilize and because the bellow-like air sacs in living birds only rarely penetrate (pneumatize) skeletal bone and thus leave a record of their presence. Methodology/Principal Findings We describe a new predatory dinosaur from Upper Cretaceous rocks in Argentina, Aerosteon riocoloradensis gen. et sp. nov., that exhibits extreme pneumatization of skeletal bone, including pneumatic hollowing of the furcula and ilium. In living birds, these two bones are pneumatized by diverticulae of air sacs (clavicular, abdominal) that are involved in pulmonary ventilation. We also describe several pneumatized gastralia (“stomach ribs”), which suggest that diverticulae of the air sac system were present in surface tissues of the thorax. Conclusions/Significance We present a four-phase model for the evolution of avian air sacs and costosternal-driven lung ventilation based on the known fossil record of theropod dinosaurs and osteological correlates in extant birds: (1) Phase I—Elaboration of paraxial cervical air sacs in basal theropods no later than the earliest Late Triassic. (2) Phase II—Differentiation of avian ventilatory air sacs, including both cranial (clavicular air sac) and caudal (abdominal air sac) divisions, in basal tetanurans during the Jurassic. A heterogeneous respiratory tract with compliant air sacs, in turn, suggests the presence of rigid, dorsally attached lungs with flow-through ventilation. (3) Phase III—Evolution of a primitive costosternal pump in maniraptoriform theropods before the close of the Jurassic. (4) Phase IV—Evolution of an advanced costosternal pump in maniraptoran theropods before the close of the

  5. Anisotropic shrinkage of insect air sacs revealed in vivo by X-ray microtomography

    OpenAIRE

    2016-01-01

    Air sacs are thought to be the bellows for insect respiration. However, their exact mechanism of action as a bellows remains unclear. A direct way to investigate this problem is in vivo observation of the changes in their three-dimensional structures. Therefore, four-dimensional X-ray phase contrast microtomography is employed to solve this puzzle. Quantitative analysis of three-dimensional image series reveals that the compression of the air sac during respiration in bell crickets exhibits o...

  6. Anisotropic shrinkage of insect air sacs revealed in vivo by X-ray microtomography

    Science.gov (United States)

    Xu, Liang; Chen, Rongchang; Du, Guohao; Yang, Yiming; Wang, Feixiang; Deng, Biao; Xie, Honglan; Xiao, Tiqiao

    2016-09-01

    Air sacs are thought to be the bellows for insect respiration. However, their exact mechanism of action as a bellows remains unclear. A direct way to investigate this problem is in vivo observation of the changes in their three-dimensional structures. Therefore, four-dimensional X-ray phase contrast microtomography is employed to solve this puzzle. Quantitative analysis of three-dimensional image series reveals that the compression of the air sac during respiration in bell crickets exhibits obvious anisotropic characteristics both longitudinally and transversely. Volumetric changes of the tracheal trunks in the prothorax further strengthen the evidence of this finding. As a result, we conclude that the shrinkage and expansion of the insect air sac is anisotropic, contrary to the hypothesis of isotropy, thereby providing new knowledge for further research on the insect respiratory system.

  7. Ventilation patterns of the songbird lung/air sac system during different behaviors.

    Science.gov (United States)

    Mackelprang, Rebecca; Goller, Franz

    2013-10-01

    Unidirectional, continuous airflow through the avian lung is achieved through an elaborate air sac system with a sequential, posterior to anterior ventilation pattern. This classical model was established through various approaches spanning passively ventilated systems to mass spectrometry analysis of tracer gas flow into various air sacs during spontaneous breathing in restrained ducks. Information on flow patterns in other bird taxa is missing, and these techniques do not permit direct tests of whether the basic flow pattern can change during different behaviors. Here we use thermistors implanted into various locations of the respiratory system to detect small pulses of tracer gas (helium) to reconstruct airflow patterns in quietly breathing and behaving (calling, wing flapping) songbirds (zebra finch and yellow-headed blackbird). The results illustrate that the basic pattern of airflow in these two species is largely consistent with the model. However, two notable differences emerged. First, some tracer gas arrived in the anterior set of air sacs during the inspiration during which it was inhaled, suggesting a more rapid throughput through the lung than previously assumed. Second, differences in ventilation between the two anterior air sacs emerged during calling and wing flapping, indicating that adjustments in the flow pattern occur during dynamic behaviors. It is unclear whether this modulation in ventilation pattern is passive or active. This technique for studying ventilation patterns during dynamic behaviors proves useful for establishing detailed timing of airflow and modulation of ventilation in the avian respiratory system.

  8. Penguin lungs and air sacs: implications for baroprotection, oxygen stores and buoyancy.

    Science.gov (United States)

    Ponganis, P J; St Leger, J; Scadeng, M

    2015-03-01

    The anatomy and volume of the penguin respiratory system contribute significantly to pulmonary baroprotection, the body O2 store, buoyancy and hence the overall diving physiology of penguins. Therefore, three-dimensional reconstructions from computerized tomographic (CT) scans of live penguins were utilized to measure lung volumes, air sac volumes, tracheobronchial volumes and total body volumes at different inflation pressures in three species with different dive capacities [Adélie (Pygoscelis adeliae), king (Aptenodytes patagonicus) and emperor (A. forsteri) penguins]. Lung volumes scaled to body mass according to published avian allometrics. Air sac volumes at 30 cm H2O (2.94 kPa) inflation pressure, the assumed maximum volume possible prior to deep dives, were two to three times allometric air sac predictions and also two to three times previously determined end-of-dive total air volumes. Although it is unknown whether penguins inhale to such high volumes prior to dives, these values were supported by (a) body density/buoyancy calculations, (b) prior air volume measurements in free-diving ducks and (c) previous suggestions that penguins may exhale air prior to the final portions of deep dives. Based upon air capillary volumes, parabronchial volumes and tracheobronchial volumes estimated from the measured lung/airway volumes and the only available morphometry study of a penguin lung, the presumed maximum air sac volumes resulted in air sac volume to air capillary/parabronchial/tracheobronchial volume ratios that were not large enough to prevent barotrauma to the non-collapsing, rigid air capillaries during the deepest dives of all three species, and during many routine dives of king and emperor penguins. We conclude that volume reduction of airways and lung air spaces, via compression, constriction or blood engorgement, must occur to provide pulmonary baroprotection at depth. It is also possible that relative air capillary and parabronchial volumes are

  9. Air sac PO2 and oxygen depletion during dives of emperor penguins.

    Science.gov (United States)

    Knower Stockard, T; Heil, J; Meir, J U; Sato, K; Ponganis, K V; Ponganis, P J

    2005-08-01

    In order to determine the rate and magnitude of respiratory O2 depletion during dives of emperor penguins (Aptenodytes forsteri), air sac O2 partial pressure (PO2) was recorded in 73 dives of four birds at an isolated dive hole. These results were evaluated with respect to hypoxic tolerance, the aerobic dive limit (ADL; dive duration beyond which there is post-dive lactate accumulation) and previously measured field metabolic rates (FMRs). 55% of dives were greater in duration than the previously measured 5.6-min ADL. PO2 and depth profiles revealed compression hyperoxia and gradual O2 depletion during dives. 42% of final PO2s during the dives (recorded during the last 15 s of ascent) were emperors. In dives of durations greater than the ADL, the calculated end-of-dive air sac O2 fraction was <4%. The respiratory O2 store depletion rate of an entire dive, based on the change in O2 fraction during a dive and previously measured diving respiratory volume, ranged from 1 to 5 ml O2 kg(-1) min(-1) and decreased exponentially with diving duration. The mean value, 2.1+/-0.8 ml O2 kg(-1) min(-1), was (1) 19-42% of previously measured respiratory O(2) depletion rates during forced submersions and simulated dives, (2) approximately one-third of the predicted total body resting metabolic rate and (3) approximately 10% of the measured FMR. These findings are consistent with a low total body metabolic rate during the dive.

  10. Detection and Management of Air Sac Trematodes (Szidatitrema Species) in Captive Multispecies Avian Exhibits.

    Science.gov (United States)

    Delaski, Kristina M; Nelson, Sudona; Dronen, Norman O; Craig, Thomas M; Pond, Joel; Gamble, Kathryn C

    2015-12-01

    From 2 exhibits in a zoological collection, 2 juvenile fairy bluebirds ( Irena puella ) and 1 adult blue-grey tanager (Thraupis episcopus) died within 3 months of one another. The cause of death was attributed to air sac trematodes, which were identified as Szidatitrema species based on morphology of adult trematodes and miracidia isolated from a snail intermediate host. To determine the extent of trematodiasis in the collection, individual exhibits within the same building as the original presenting cases were assessed, with birds representing 27 avian species from 9 orders. Sampling consisted of individual (n = 244) and pooled same-species group (n = 193) fecal examinations, and for some individuals, and tracheal swab (n = 106), resulting in a total of 543 samples. In addition, tracheal swabs were performed on 14 birds for comparative cytology, but no parasites were found. Flukes were positively identified in 4 tracheal swab samples (4%), 37 individual fecal samples (15%), and 52 of the group fecal samples (27%). When results of the swab method were compared with those of fecal examination, fecal testing was significantly associated (P birds housed in exhibits known to have snail populations. Snail control methods also were initiated in all exhibits. Treatment with praziquantel was carried out on a case-by-case basis, and included oral, parenteral, and nebulized administration. Although control measures were expected to manage the infection and reduce distribution of the parasite to other collections, complete eradication of trematodes in the population is unlikely.

  11. Motor control of sound frequency in birdsong involves the interaction between air sac pressure and labial tension

    Science.gov (United States)

    Alonso, Rodrigo; Goller, Franz; Mindlin, Gabriel B.

    2014-03-01

    Frequency modulation is a salient acoustic feature of birdsong. Its control is usually attributed to the activity of syringeal muscles, which affect the tension of the labia responsible for sound production. We use experimental and theoretical tools to test the hypothesis that for birds producing tonal sounds such as domestic canaries (Serinus canaria), frequency modulation is determined by both the syringeal tension and the air sac pressure. For different models, we describe the structure of the isofrequency curves, which are sets of parameters leading to sounds presenting the same fundamental frequencies. We show how their shapes determine the relative roles of syringeal tension and air sac pressure in frequency modulation. Finally, we report experiments that allow us to unveil the features of the isofrequency curves.

  12. Analysis of air-conditioning and drying processes using spreadsheet add-in for psychrometric data

    Directory of Open Access Journals (Sweden)

    E.O. Diemuodeke

    2010-01-01

    Full Text Available A spreadsheet add-in for the psychrometric data at any barometric pressure and in the air-conditioning and drying temperatureranges was developed using appropriate correlations. It was then used to simulate and analyse air-conditioning and dryingprocesses in the Microsoft Excel environment by exploiting its spreadsheet and graphic potentials. The package allowsone to determine the properties of humid air at any desired state, and to simulate and analyse air-conditioning as well asdrying processes. This, as a teaching tool, evokes the intellectual curiosity of students and enhances their interest and abilityin the thermodynamics of humid-air processes.

  13. Development, structure, and function of a novel respiratory organ, the lung-air sac system of birds: to go where no other vertebrate has gone.

    Science.gov (United States)

    Maina, John N

    2006-11-01

    Among the air-breathing vertebrates, the avian respiratory apparatus, the lung-air sac system, is the most structurally complex and functionally efficient. After intricate morphogenesis, elaborate pulmonary vascular and airway (bronchial) architectures are formed. The crosscurrent, countercurrent, and multicapillary serial arterialization systems represent outstanding operational designs. The arrangement between the conduits of air and blood allows the respiratory media to be transported optimally in adequate measures and rates and to be exposed to each other over an extensive respiratory surface while separated by an extremely thin blood-gas barrier. As a consequence, the diffusing capacity (conductance) of the avian lung for oxygen is remarkably efficient. The foremost adaptive refinements are: (1) rigidity of the lung which allows intense subdivision of the exchange tissue (parenchyma) leading to formation of very small terminal respiratory units and consequently a vast respiratory surface; (2) a thin blood-gas barrier enabled by confinement of the pneumocytes (especially the type II cells) and the connective tissue elements to the atria and infundibulae, i.e. away from the respiratory surface of the air capillaries; (3) physical separation (uncoupling) of the lung (the gas exchanger) from the air sacs (the mechanical ventilators), permitting continuous and unidirectional ventilation of the lung. Among others, these features have created an incredibly efficient gas exchanger that supports the highly aerobic lifestyles and great metabolic capacities characteristic of birds. Interestingly, despite remarkable morphological heterogeneity in the gas exchangers of extant vertebrates at maturity, the processes involved in their formation and development are very similar. Transformation of one lung type to another is clearly conceivable, especially at lower levels of specialization. The crocodilian (reptilian) multicameral lung type represents a Bauplan from which the

  14. A Qualitative Analysis of SAC Aircraft Maintenance.

    Science.gov (United States)

    1982-09-01

    A122 815 A QUALITATIVE ANALYSIS OF SAC AIRCRAFT MRINTENANCE(U) 112 AIR FORCE INST OF TECH WRIGHT-PRTTERSON AFB OH SCHOOL OF SYSTEMS AND LOGISTICS D...Wright-Patterson Air Force Base, Ohio ’ ; " ... ..... ... ... . .. .. A QUALITATIVE ANALYSIS OF SAC AIRCRAFT MAINTENANCE Douglas P. Cook, Captain... QUALITATIVE ANALYSIS OF SAC Master’s Thesis AIRCRAFT MAINTENANCE 6. PERFORMING ORG. REPORT NUMBER 7. AUTHOR(q) S. CONTRACT OR GRANT NUMBER(a) Douglas

  15. Boundary conditions for heat transfer and evaporative cooling in the trachea and air sac system of the domestic fowl: a two-dimensional CFD analysis.

    Directory of Open Access Journals (Sweden)

    Nina S Sverdlova

    Full Text Available Various parts of the respiratory system play an important role in temperature control in birds. We create a simplified computational fluid dynamics (CFD model of heat exchange in the trachea and air sacs of the domestic fowl (Gallus domesticus in order to investigate the boundary conditions for the convective and evaporative cooling in these parts of the respiratory system. The model is based upon published values for respiratory times, pressures and volumes and upon anatomical data for this species, and the calculated heat exchange is compared with experimentally determined values for the domestic fowl and a closely related, wild species. In addition, we studied the trachea histologically to estimate the thickness of the heat transfer barrier and determine the structure and function of moisture-producing glands. In the transient CFD simulation, the airflow in the trachea of a 2-dimensional model is evoked by changing the volume of the simplified air sac. The heat exchange between the respiratory system and the environment is simulated for different ambient temperatures and humidities, and using two different models of evaporation: constant water vapour concentration model and the droplet injection model. According to the histological results, small mucous glands are numerous but discrete serous glands are lacking on the tracheal surface. The amount of water and heat loss in the simulation is comparable with measured respiratory values previously reported. Tracheal temperature control in the avian respiratory system may be used as a model for extinct or rare animals and could have high relevance for explaining how gigantic, long-necked dinosaurs such as sauropoda might have maintained a high metabolic rate.

  16. Boundary conditions for heat transfer and evaporative cooling in the trachea and air sac system of the domestic fowl: a two-dimensional CFD analysis.

    Science.gov (United States)

    Sverdlova, Nina S; Lambertz, Markus; Witzel, Ulrich; Perry, Steven F

    2012-01-01

    Various parts of the respiratory system play an important role in temperature control in birds. We create a simplified computational fluid dynamics (CFD) model of heat exchange in the trachea and air sacs of the domestic fowl (Gallus domesticus) in order to investigate the boundary conditions for the convective and evaporative cooling in these parts of the respiratory system. The model is based upon published values for respiratory times, pressures and volumes and upon anatomical data for this species, and the calculated heat exchange is compared with experimentally determined values for the domestic fowl and a closely related, wild species. In addition, we studied the trachea histologically to estimate the thickness of the heat transfer barrier and determine the structure and function of moisture-producing glands. In the transient CFD simulation, the airflow in the trachea of a 2-dimensional model is evoked by changing the volume of the simplified air sac. The heat exchange between the respiratory system and the environment is simulated for different ambient temperatures and humidities, and using two different models of evaporation: constant water vapour concentration model and the droplet injection model. According to the histological results, small mucous glands are numerous but discrete serous glands are lacking on the tracheal surface. The amount of water and heat loss in the simulation is comparable with measured respiratory values previously reported. Tracheal temperature control in the avian respiratory system may be used as a model for extinct or rare animals and could have high relevance for explaining how gigantic, long-necked dinosaurs such as sauropoda might have maintained a high metabolic rate.

  17. [Anti-angiogenic activities of UFT and its metabolites, GHB and GBL, in the dorsal air sac (DAS) model in mice].

    Science.gov (United States)

    Basaki, Y; Yonekura, K; Chikahisa, L; Okabe, S; Hashimoto, A; Miyadera, K; Aoyagi, K; Yamada, Y

    2000-01-01

    We investigated the effects of UFT and its metabolites, GHB and GBL, on angiogenesis induced by tumor cells in a dorsal air sac (DAS) assay in mice. Five tumor cell lines (murine renal carcinoma; RENCA, human gastric cancer; 4-1ST, human small-cell lung carcinoma; LX-1, and human colon carcinoma; DLD-1, KM-20C) were used in the DAS assay. In this model, UFT demonstrated a significant anti-angiogenic activity in a dose-dependent manner while 5-FU (19 mg/kg/day) and 5'-DFUR (200 mg/kg/day) were less effective. Moreover, tegafur (FT), a component of UFT, and gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL), in vivo metabolites of UFT, inhibited angiogenesis induced by RENCA cells. The inhibitory effects of 5-FU, GHB, and GBL on angiogenesis were increased with administration by continuous infusion, providing a suitable pharmacokinetic profile. These results suggest that GHB and GBL are involved in the expression of anti-angiogenic activity of UFT.

  18. Main: SAC101 [AT Atlas

    Lifescience Database Archive (English)

    Full Text Available SAC101 SAC1 Development of the synchrotron beamlines dedicated to the measurement o...f micron-size protein crystals Development of the synchrotron beamlines dedicated to the measurement of micr

  19. The Sac Actun System, Quintana Roo, Mexico; Sistema Sac Actun, Quintana Roo, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Kambesis, P. N.; Coke, J. G.

    2016-07-01

    The Sac Actun system, located in northeast Quintana Roo, Mexico, is among the most extensive underwater cave systems located along the Caribbean coast of the Yucatan Peninsula. The cave is composed of linear phreatic conduits that have two forms. The coastal sections of the Sac Actun system are characterized by low horizontal tunnels that form mazes paralleling the coast and rudimentary conduits broken by fracture-controlled rooms. Inland passages are fault/fracture controlled, have a linear, anastomotic configuration, and align perpendicular to the coast. Access to the cave system is gained through cenotes which are the portals into the Yucatan underwater cave systems. The occurrence of drowned speleothems in many parts of the cave system, and sections of air-filled upper level passages are indicative of major fluctuations in sea level. The Sac Actun system is part of one of the most extensive and significant eogenetic karst aquifers in the world. The development of the Sac Actun system, as well as the many other caves systems along the Yucatan Caribbean Coast is controlled by the coastal hydrologic regime, driven by glacio-eustatics, and influenced by stratigraphic and structural controls. The karstic permeability of the aquifer makes it and the Sac Actun system vulnerable to the anthropogenic impacts of increased population growth, quarries, and infrastructure development associated with the burgeoning tourist industry that dominates land use in the region. (Author)

  20. Primary Teratoma of the Lesser Sac: Lesser Sac Teratoma

    Directory of Open Access Journals (Sweden)

    Brandon M. Hardesty

    2012-01-01

    Full Text Available Germ cell tumors predominantly involve the gonads but may rarely be found outside of the gonads, primarily in midline structures. We describe the case of a 27-year-old male with an asymptomatic 8 cm teratoma located within the lesser sac of his omentum. This is the fourth case of a teratoma located within the lesser sac of the omentum, which provides the opportunity to make some comparisons. Finally, we discuss some of the etiologic theories behind extragonadal germ cell tumors and how they relate to teratomas in the lesser sac.

  1. Haemangiopericytoma of the lacrimal sac.

    Science.gov (United States)

    Watanabe, Akihide; Wu, Albert; Sun, Michelle T; Inatani, Masaru; Katori, Nobutada; Selva, Dinesh

    2016-08-01

    Haemangiopericytomas (HPCs) are rare tumours which infrequently occur in the lacrimal sac. Only 8 cases of lacrimal sac HPC have previously been reported. The authors report 2 additional cases presenting clinically with epiphora and a mass. One case recurred 3 times during an 18-year period. The other case did not recur during 51 months of follow-up. The tumours showed immunohistochemical features consistent with a diagnosis of HPC. The authors recommend wide excision for these tumours and careful long-term follow-up to detect recurrence which is not uncommon.

  2. Endolymphatic sac involvement in bacterial meningitis

    DEFF Research Database (Denmark)

    Møller, Martin Nue; Brandt, Christian; Andersen, Christian Østergaard;

    2015-01-01

    The commonest sequelae of bacterial meningitis are related to the inner ear. Little is known about the inner ear immune defense. Evidence suggests that the endolymphatic sac provides some protection against infection. A potential involvement of the endolymphatic sac in bacterial meningitis......-inoculated. The rats were killed when reaching terminal illness or on day 7, followed by light microscopy preparation and PAS-Alcian blue staining. The endolymphatic sac was examined for bacterial invasion and leukocyte infiltration. Neither bacteria nor leukocytes infiltrated the endolymphatic sac during the first...... days. Bacteria invaded the inner ear through the cochlear aquaduct. On days 5-6, the bacteria invaded the endolymphatic sac through the endolymphatic duct subsequent to invasion of the vestibular endolymphatic compartment. No evidence of direct bacterial invasion of the sac through the meninges...

  3. Unusual encounters in a hernia sac

    Directory of Open Access Journals (Sweden)

    Ketan Vagholkar

    2016-05-01

    Full Text Available Contents of a hernia sac are always a surprise. In most cases the contents of the sac determine the type of repair. A case of an inguinal hernia sac containing the appendix along with the dislodged end of a ventriculoperitoneal shunt tube is presented in view of its rarity. [Int J Res Med Sci 2016; 4(5.000: 1728-1729

  4. Benign mixed tumor of the lacrimal sac

    Directory of Open Access Journals (Sweden)

    Jong-Suk Lee

    2015-01-01

    Full Text Available Neoplasms of the lacrimal drainage system are uncommon, but potentially life-threatening and are often difficult to diagnose. Among primary lacrimal sac tumors, benign mixed tumors are extremely rare. Histologically, benign mixed tumors have been classified as a type of benign epithelial tumor. Here we report a case of benign mixed tumor of the lacrimal sac.

  5. Experimental Hyperactivity of the Endolymphatic Sac

    DEFF Research Database (Denmark)

    Friis, Morten; Thomsen, Allan Randrup; Poulsen, Steen Seier

    2013-01-01

    Injury to the endolymphatic sac may play an important role in the pathogenesis of Ménière's disease, an inner ear disorder characterized by hearing loss, tinnitus and attacks of vertigo. Isoimmunization of 16 inbred Lewis rats with a crude endolymphatic sac extract and complete Freund's adjuvant...

  6. New Administrator of SAC, Chen Gang

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    On June 14th,SAC held a meeting presented by its middle-high officials,at which Zhang Qinrong,Member of CPC Leading Group and Director of Personnel Department,General Administration of Quality Supervision,Inspection and Quarantine (AQSIQ),announced the personnel decision made by the State Council,the Organization Department of the CPC Central Committee and AQSIQ.In the decision,Chen Gang was appointed as Member of CPC Leading Group of AQSIQ,Administrator of SAC and Secretary of CPC Leading Group of SAC,and Ji Zhengkun was dismissed as the Member of CPC Leading Group of AQSIQ,Administrator of SAC and Secretary of CPC Leading Group of SAC.The meeting was presided by Ji Zhengkun.Zhi Shuping,Minister of AQSIQ and Secretary of CPC Leading Group of AQSIQ,attended the meeting and gave a speech.Ji Zhengkun and Chen Gang also delivered speeches.

  7. SACS: Spitzer Archival Cluster Survey

    Science.gov (United States)

    Stern, Daniel

    Emerging from the cosmic web, galaxy clusters are the most massive gravitationally bound structures in the universe. Thought to have begun their assembly at z > 2, clusters provide insights into the growth of large-scale structure as well as the physics that drives galaxy evolution. Understanding how and when the most massive galaxies assemble their stellar mass, stop forming stars, and acquire their observed morphologies in these environments remain outstanding questions. The redshift range 1.3 galaxies start to become the dominant population in cluster cores, and star formation in spiral galaxies is being quenched. Until recently, however, this redshift range was essentially unreachable with available instrumentation, with clusters at these redshifts exceedingly challenging to identify from either ground-based optical/nearinfrared imaging or from X-ray surveys. Mid-infrared (MIR) imaging with the IRAC camera on board of the Spitzer Space Telescope has changed the landscape. High-redshift clusters are easily identified in the MIR due to a combination of the unique colors of distant galaxies and a negative k-correction in the 3-5 μm range which makes such galaxies bright. Even 90-sec observations with Spitzer/IRAC, a depth which essentially all extragalactic observations in the archive achieve, is sufficient to robustly detect overdensities of L* galaxies out to z~2. Here we request funding to embark on a ambitious scientific program, the “SACS: Spitzer Archival Cluster Survey”, a comprehensive search for the most distant galaxy clusters in all Spitzer/IRAC extragalactic pointings available in the archive. With the SACS we aim to discover ~2000 of 1.3 star formation and AGN activity out to z~2, and to study the effect of star-forming galaxies and AGNs on cosmological results from ongoing Sunyaev-Zel'dovich (SZ) and X-ray cluster surveys. The identified clusters will be valuable for both astrophysics and cosmology. In terms of astrophysics, the redshift probed

  8. Hernia sacs: is histological examination necessary?

    Science.gov (United States)

    Wang, Tao; Vajpeyi, Rajkumar

    2013-12-01

    The hernia sac is a common surgical pathology specimen which can occasionally yield unexpected diagnoses. The College of American Pathologists recommends microscopic examination of abdominal hernias, but leaves submission of inguinal hernias for histology to the discretion of the pathologist. To validate this approach at a tertiary care centre, we retrospectively reviewed 1426 hernia sacs derived from inguinal, femoral and abdominal wall hernias. The majority of pathologies noted were known to the clinician, including herniated bowel, lipomas and omentum. A malignancy was noted in three of 800 inguinal hernias and seven of 576 abdominal wall hernias; five of these lesions were not seen on gross examination. Other interesting findings in hernia sacs included appendices, endometriosis, a perivascular epithelioid cell tumour, and pseudomyxoma peritoneii. All hernia sacs should be examined grossly as most pathologies are grossly visible. The decision to submit inguinal hernias for histology may be left to the discretion of the pathologist, but abdominal and femoral hernias should be submitted for histology.

  9. Gene Expression in the Human Endolymphatic Sac

    DEFF Research Database (Denmark)

    Møller, Martin Nue; Kirkeby, Svend; Vikeså, Jonas;

    2015-01-01

    of fresh human endolymphatic sac tissue samples. METHODS: Twelve tissue samples of the human endolymphatic sac were obtained during translabyrinthine surgery for vestibular schwannoma. Microarray technology was used to investigate tissue sample expression of solute carrier family genes, using adjacent dura......a1 sodium-bicarbonate transporter, SLC9a2 sodium-hydrogen transporter, SLC12a3 thiazide-sensitive Na-Cl transporter, and SLC34a2 sodium-phosphate transporter. CONCLUSIONS: Several important ion transporters of the SLC family are expressed in the human endolymphatic sac, including Pendrin......OBJECTIVES/HYPOTHESIS: The purpose of the present study is to explore, demonstrate, and describe the expression of genes related to the solute carrier (SLC) molecules of ion transporters in the human endolymphatic sac. STUDY DESIGN: cDNA microarrays and immunohistochemistry were used for analyses...

  10. Hydrocoele of a femoral hernia sac.

    Science.gov (United States)

    Mote, D G; Chakravarty, K B

    2009-12-01

    Hydrocoele of a femoral hernia sac is an extremely rare entity. Extensive literature review and Internet searching revealed only a few authentically reported cases. It mostly occurs in females during the fourth to sixth decades of life. The most common clinical presentation is groin swelling. It is diagnosed as an irreducible or incarcerated femoral hernia or subcutaneous lipoma. In almost all of the reported cases, the diagnosis of hydrocoele of a femoral hernia sac has been made only after surgical exploration. The present case is a 40-year-old lady who presented with a painless lump in the right groin and was diagnosed as a case of hydrocoele of a femoral hernia sac only after exploration.

  11. The endolymphatic sac, a potential endocrine gland?

    DEFF Research Database (Denmark)

    Qvortrup, K; Rostgaard, J; Holstein-Rathlou, N H;

    1999-01-01

    is described, demonstrating that this organ fulfils the morphological criteria of a potential endocrine gland. Accordingly, the chief cells are shown to exhibit all the organelles and characteristics of cells that simultaneously synthesize, secrete, absorb and digest proteins.......A previous investigation indicated that the chief cells of the endolymphatic sac produce an endogenous inhibitor of sodium re-absorption in the kidneys, which has tentatively been named "saccin". In this study, the ultrastructure of the endolymphatic sac and in particular the chief cells...

  12. Methylphenidate, Add, and Classroom Performance

    OpenAIRE

    1993-01-01

    The degree to which methylphenidate (MPH) normalized the classroom behavior and academic functioning of 31 children with attention deficit disorder (ADD) was evaluated at Lehigh University, Bethlehem, PA.

  13. [Yolk sac tumor. Report of a case].

    Science.gov (United States)

    Debbagh, A; Bennani, S; Jouhadi, H; Joual, A; el Mrini, M; Kahlain, A; Benjelloun, S

    2001-11-01

    Yolk sac tumor is rare in adult. We report a case in a young man aged of 23 years treated by orchiectomy, chemotherapy and retroperitoneal lymphadenectomy. Diagnosis is based on pathology who shows other cellular contingents. Treatment is based on orchiectomy and chemotherapy is indicated for residula masses. The prognosis is bad because metastasis is frequent.

  14. 微生物燃料电池MnO2/S-AC泡沫镍空气阴极的制备及其性能%Preparation and properties of nickel foam air cathode with MnO2/S-AC catalyst for microbial fuel cells

    Institute of Scientific and Technical Information of China (English)

    杨斯琦; 刘中良; 侯俊先; 周宇

    2015-01-01

    The kinetics of oxygen reduction of cathode catalyst is a critical factor that limits the performance of microbial fuel cells (MFCs). The composite catalyst of three composite proportion(1:3, 1:1 and 3:1), which were prepared by reacting KMnO4 with supercapacitor activated carbon (S-AC),were tested as air-cathode catalyst of microbial fuel cells (MFCs) for oxygen reduction. X-ray diffraction (XRD) was used to characterize the catalysts, energy dispersive X-Ray Spectroscopy to estimate the quality of MnO2, scanning electron microscopy (SEM) to observe the surface morphology, and BET method to examine surface area and pore distribution characteristics, to analyze the factors affecting the performance of the composite catalyst. With increasing of composite proportion, the MnO2 sheets gathered into nano-particles (300—500 nm) on the surface of S-AC. At the same time, there is the decrease of the internal and external surface area MnO2/S-AC. Nickel foam air-cathode was made with different catalysts, and tested in air-cathode MFCs to study the effect on MFC performance by linear sweep voltammetry (LSV), polarization curves and power density curve. When the feeding ratio of KMnO4: S-AC is 1:3,the maximum power density was 321.2 mW·m?2, which was increased by about 20% over the S-AC loading MFC. However, when the feeding ratio was increased to 1:1 and 3:1, the maximum power density decreased to 240.9 and 160.3 mW·m?2. MnO2/S-AC composite catalyst within a certain ratio range could effectively improve the performance of air-cathode and MFC, which helps to the expansion application of air-cathode MFC.%利用超级电容器活性炭(S-AC)直接还原KMnO4制备出复合比例分别为1:3、1:1和3:1的MnO2/S-AC复合催化剂,进而负载于泡沫镍上制得MnO2/S-AC泡沫镍空气阴极.通过X射线衍射(XRD)、扫描电镜(SEM)、能量散射X 射线谱(EDX)和比表面积(BET)及孔分布测试对所制复合催化剂表征可知,随复合比例

  15. Three National Standardization Technical Committees Authorized By SAC

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ In December, 2004, the Standardization Administration of China (SAC) has approved the establishments of three National Standardization Technical Committees. They are the National Standardization Technical Committees for Environmental Protection Products (SAC/TC275), for Safety Management of Agricultural Transgenic Biology (SAC/TC276) and for Testing of New Varieties of Plant (SAC/TC277).The National Standardization Technical Committee for Environmental Protection Products is responsible for the development and revision of national standards in the following fields:

  16. Characterizing the Mechanical Properties of Actual SAC105, SAC305, and SAC405 Solder Joints by Digital Image Correlation

    Science.gov (United States)

    Nguyen, T. T.; Yu, D.; Park, S. B.

    2011-06-01

    This paper presents the characterization of the mechanical properties of three lead-free solder alloys 95.5Sn-4.0Ag-0.5Cu (SAC405), 96.5Sn-3.0Ag-0.5Cu (SAC305), and 98.5Sn-1.0Ag-0.5Cu (SAC105) at the solder joint scale. Several actual ChipArray ® ball grid array (CABGA) packages were cross-sectioned, polished, and used as test vehicles. Compressive tests were performed using a nanocharacterization system over the temperature range of 25°C to 105°C. Images of the cross-sectioned solder joints were recorded by microscope during the tests. The recorded images were then processed by using a digital image correlation (DIC) program to calculate the displacement and strain fields on the solder joints. Finite-element method (FEM) modeling was used to extract the Poisson's ratio, Young's modulus, and coefficient of thermal expansion (CTE) of the solder alloys over the temperature range. The methodology developed in this paper enables characterization of the mechanical properties of the actual solder joints at low strain range with high accuracy.

  17. Femoral hernia sac laparoscopy: a case report.

    Science.gov (United States)

    Ramirez Valderrama, Alexander; Ruiz, Dan; Malik, Manmeet; Tiszenkel, Howard

    2014-01-01

    We present the case of a 64-year-old female with an incarcerated right femoral hernia, associated with a small bowel obstruction that was successfully treated with an open femoral hernia repair with plug. At the same time we performed a hernia sac laparoscopy to evaluate the viability of the previously reduced small bowel. The hernioscopy was performed with a 0° 5 mm scope with reliable evaluation of the peritoneal cavity. We confirm that hernioscopy is a safe and feasible procedure and provides useful information for the appropriate management of acute incarcerated femoral/inguinal hernias.

  18. Congenital lacrimal sac fistula: intraoperative visualization by polyvinyl siloxane cast.

    Science.gov (United States)

    Bhatnagar, Aparna; Eckstein, Lauren A; Douglas, Raymond S; Goldberg, Robert A

    2008-01-01

    We report the intraoperative use of polyvinyl siloxane impression material to demonstrate the anatomy of the lacrimal sac, canaliculi, and lacrimal duct in a case of congenital lacrimal sac fistula. A 1-week-old boy was examined for tearing since birth. Examination revealed a left congenital lacrimal sac fistula. After a failed surgery to close the fistula with silicone intubation at 6 months of age, the patient underwent endonasal dacryocystorhinostomy performed at 14 months of age, aided by intraoperative injection of polyvinyl siloxane (trade name Reprosil) to mark and protect the nasolacrimal sac and facilitate endonasal visualization. A polyvinyl siloxane cast demonstrated the anatomy of the accessory canaliculus causing nasolacrimal duct obstruction. Postoperatively, the epiphora resolved and the fistula remained closed. The polyvinyl siloxane cast provides a 3-dimensional "ex vivo " model of the lacrimal sac, upper duct, and canalicular anatomy, and can be used in dacryocystorhinostomy surgery to identify and protect the lacrimal sac.

  19. Human papillomavirus: cause of epithelial lacrimal sac neoplasia?

    DEFF Research Database (Denmark)

    Sjö, Nicolai Christian; von Buchwald, Christian; Cassonnet, Patricia

    2007-01-01

    PURPOSE: Epithelial tumours of the lacrimal sac are rare but important entities that may carry grave prognoses. In this study the prevalence and possible role of human papillomavirus (HPV) infection in epithelial tumours of the lacrimal sac were evaluated. METHODS: Five papillomas and six...... 11 RNA was demonstrated in two papillomas. CONCLUSIONS: By analysing 11 epithelial lacrimal sac papillomas and carcinomas using PCR, DNA ISH and RNA ISH, we found HPV DNA in all investigated transitional epithelium tumours of the lacrimal sac. HPV RNA was present in two of eight epithelial lacrimal...... sac tumours positive for HPV DNA. As RNA degrades fast in paraffin-embedded tissue, only a small fraction of DNA-positive tumours can be expected to be RNA-positive. We therefore suggest that HPV infection is associated with the development of lacrimal sac papillomas and carcinomas....

  20. Advanced Stellar Compass, SAC-C, Interface Control Document

    DEFF Research Database (Denmark)

    Madsen, Peter Buch; Betto, Maurizio; Riis, Troels;

    Interface Control Document for the Advanced Stellar Compass for the SAC-C satellite. The SAC-C is Argentine, Danish and NASA satellite. On the SAC-C satellite there are a simplified version of the Ørsted instrumentation platform. The Advanced Stellar Compass is a improved version of the Ørsted Star...... Imager. This document descibes the interface between the Advanced Stellar Compass and OBDH, the size of the DPU and the Camera etc....

  1. Squamous cell carcinoma of the anal sacs in three dogs.

    Science.gov (United States)

    Mellett, S; Verganti, S; Murphy, S; Bowlt, K

    2015-03-01

    Anal sac squamous cell carcinoma is rare in dogs. Five cases have been previously reported, treatment of which involved surgery alone. This report describes three further cases of canine anal sac squamous cell carcinoma which underwent medical (meloxicam) management alone, resulting in survival of up to seven months. No metastases were identified. Squamous cell carcinoma, although extremely uncommon, should be considered as a possible differential diagnosis when a dog is presented for investigation of an anal sac mass.

  2. Lacrimal Sac Dacryoliths-Pathogenesis and Composition

    Directory of Open Access Journals (Sweden)

    Serdar Özer

    2013-06-01

    Full Text Available The Main objective of the present study is to review the literature about the chemical composition and the formation of dacryoliths. Dacryoliths are calculi of the lacrimal system observed incidentally during dacryocystorhinostomy. Theories about the formation of dacryoliths mainly suppose that dacryoliths are simply a secondary phenomenon resulting from a lacrimal pathway obstruction and accumulation of debris. Inflammation caused by fungi, most commonly Candida albicans, an eyelash within the sac, or adrenalin use are also considered to be potential causes. It was also reported that the unstable concentrations of electrolytes rather than the supersaturation of some electrolytes are related to the pathogenesis of dacryoliths. Chemical analysis of the dacryoliths in studies had revealed calcium, magnesium, potassium, sulfur, and some phosphorus. Atomic absorption spectrophotometric investigations demonstrated organic proteins and, to a much lesser extent, inorganic material. (Turk J Ophthalmol 2013; 43: 186-9

  3. The endolymphatic sac: a scanning and transmission electron microscopy study

    DEFF Research Database (Denmark)

    Qvortrup, Klaus; Bretlau, Poul

    2002-01-01

    A recent investigation has suggested that the chief cells of the endolymphatic sac produce an endogenous inhibitor of sodium resorption in the kidneys, tentatively named saccin. In the current study, the ultrastructure of the endolymphatic sac and in particular the chief cells are described to de...

  4. On the robustness of SAC silencing in closed mitosis

    Science.gov (United States)

    Ruth, Donovan; Liu, Jian

    Mitosis equally partitions sister chromatids to two daughter cells. This is achieved by properly attaching these chromatids via their kinetochores to microtubules that emanate from the spindle poles. Once the last kinetochore is properly attached, the spindle microtubules pull the sister chromatids apart. Due to the dynamic nature of microtubules, however, kinetochore-microtubule attachment often goes wrong. When this erroneous attachment occurs, it locally activates an ensemble of proteins, called the spindle assembly checkpoint proteins (SAC), which halts the mitotic progression until all the kinetochores are properly attached by spindle microtubules. The timing of SAC silencing thus determines the fidelity of chromosome segregation. We previously established a spatiotemporal model that addresses the robustness of SAC silencing in open mitosis for the first time. Here, we focus on closed mitosis by examining yeast mitosis as a model system. Though much experimental work has been done to study the SAC in cells undergoing closed mitosis, the processes responsible are not well understood. We leverage and extend our previous model to study SAC silencing mechanism in closed mitosis. We show that a robust signal of the SAC protein accumulation at the spindle pole body can be achieved. This signal is a nonlinear increasing function of number of kinetochore-microtubule attachments, and can thus serve as a robust trigger to time the SAC silencing. Together, our mechanism provides a unified framework across species that ensures robust SAC silencing and fidelity of chromosome segregation in mitosis. Intramural research program in NHLBI at NIH.

  5. Single Assignment C (SAC): High Productivity meets High Performance

    NARCIS (Netherlands)

    Grelck, C.; Zsók, V; Horváth, Z; Plasmeijer, R

    2012-01-01

    We present the ins and outs of the purely functional, data parallel programming language SaC (Single Assignment C). SaC defines state- and side-effect-free semantics on top of a syntax resembling that of imperative languages like C/C++/C# or Java: functional programming with curly brackets. In contr

  6. Dilatation of the aneurysmal sac after total arch replacement.

    Science.gov (United States)

    Watanuki, Hirotaka; Ogino, Hitoshi; Matsuda, Hitoshi; Minatoya, Kenji; Sasaki, Hiroaki; Fukuda, Tetsuya; Kitamura, Soichiro

    2008-02-01

    In our institution, total arch replacement for distal arch aneurysms is performed through a median sternotomy with antegrade selective cerebral perfusion. The distal anastomosis to the completely transected descending aorta is made through the aneurysmal sac. We report on three interesting cases presenting late dilatation of the aneurysmal sac due to collateral flow after total arch replacement.

  7. Handbook for Strategic Air Command (SAC) Management Engineering Officers (MEOs)

    Science.gov (United States)

    1985-04-01

    Codtl (205) 293-2483 33c. OFFICE SYMBOL DD FORM 1473,83 APR EDITION OF 1 JAN 73 IS OBSOLETE. SECURITY CLASSIFICATION OF THIS PAGE .i-.Vv .%■ Xs...Option 8, Option 1 - Questions and Answers —■ ’■ 71 TABLE 47 - Utility Option 8, Option 1 - Output 73 TABLE 48 - Utility Option 8, Option 1...officer should be able to: change a diaper plan an invasion del iver a speech butcher a hog conn a ship design a building write a sonnet

  8. Abnormal Structure of Embryo Sac in Autotetraploid Rice

    Institute of Scientific and Technical Information of China (English)

    GUO Hai-bin; FENG Jiu-huan; LU Yong-gen; LIU Xiang-dong

    2006-01-01

    The structures of mature embryo sacs in 13 genetic stock lines of autotetraploid rice (Oryza sativa L.), including indica,japonica and javanica, were studied by using the whole-mount stain-clearing laser scanning confocal microscopy (WCLSM).Among the 13 autotetrapioid rice, the majority of ovaries possess normal polygonum-type embryo sacs, while a few ovaries were characterized by abnormal embryo sacs. The abnormalities of embryo sacs could be classified into six categories, i. e. no female The frequency of abnormal embryo sac in japonica (26.6%) was higher than that in indica (19.34%). In addition, the major abnormalities in each autotetraploid line varied, suggesting that the abnormalities may be related to the genotypes of the varieties.

  9. Selfcoelum lamothei n. sp. (Digenea: Cyclocoelidae: Cyclocoelinae from the air sacs of the long-billed curlew, Numenius americanus (Scolopacidae, from the Galveston, Texas area, USA Selfcoelum lamothei, n. sp. (Digenea: Cyclocoelidae: Cyclocoelinae de los sacos aéreos del playero de pico largo, Numenius americanus (Scolopacidae, del área del condado de Galveston, Texas, EUA

    Directory of Open Access Journals (Sweden)

    Charles K. Blend

    2008-08-01

    Full Text Available Fourteen specimens of a new species of cyclocoelid, Selfcoelum lamothei n. sp. (Digenea: Cyclocoelidae: Cyclocoelinae, from the air sacs of a long-billed curlew, Numenius americanus Bechstein (Scolopacidae, collected from the Galveston area, Galveston County, Texas, USA, were examined. The new species has an intertesticular ovary that forms a triangle with the testes, placing it in Cyclocoelinae Stossich, 1902. The new species is most similar to Selfcoelum capellum (Khan, 1935 n. comb., but differs from this species by lacking an oral sucker and by having a somewhat larger ovary, larger testes, a smaller posttesticular space, a larger cirrus sac, larger eggs, and the vitelline follicles of S. lamothei n. sp. are more bulky making the vitelline fields more laterally extensive, and more anteriorly distributed (reaching anteriorly to the level of the pharynx compared to the level of the cecal bifurcation than those of S. capellum. The new species can be distinguished from the 2 species currently assigned to Selfcoelum Dronen, Gardner and Jiménez, 2006, S. brasilianum (Stossich, 1902 and S. limnodromi Dronen, Gardner and Jiménez, 2006, by having an intercecal uterus rather than having uterine loops that overreach the ceca laterally. The genus Selfcoelum should be emended to include those species where the uterus is either intercecal or where the uterine loops overreach the ceca laterally and those species with or without an oral sucker.Se examinaron 14 ejemplares de una nueva especie de ciclocélido, Selfcoelum lamothei n. sp. (Digenea: Cyclocoelidae: Cyclocoelinae que es parásito de los sacos aéreos del playero de pico largo, Numenius americanus Bechstein (Scolopacidae, recolectados en el condado de Galveston, Texas, EUA. La especie nueva se caracteriza por presentar el ovario en posición intertesticular, formando un triángulo con relación a los testículos. Este rasgo sitúa a la nueva especie entre los Cyclocoelinae Stossich, 1902

  10. Multi-level security for computer networking: SAC digital network approach

    Energy Technology Data Exchange (ETDEWEB)

    Griess, W.; Poutre, D.L.

    1983-10-01

    For telecommunications systems simultaneously handling data of different security levels, multilevel secure (MLS) operation permits maximum use of resources by automatically providing protection to users with various clearances and needs-to-know. The strategic air command (SAC) is upgrading the primary record data system used to command and control its strategic forces. The upgrade, called the SAC Digital Network (SACDIN), is designed to provide multilevel security to support users and external interfaces, with allowed accesses ranging from unclassified to top secret. SACDIN implements a security kernel based upon the Bell and Lapadula security model. This study presents an overview of the SACDIN security architecture and describes the basic message flow across the MLS network. 7 references.

  11. A Qualitative Analysis of Supervision in SAC Minuteman ICBM Maintenance.

    Science.gov (United States)

    1983-09-01

    8217~44IAA A -’ ff3 4% At S. ~ At .~ 4 ’ 󈧦k (A444 4 qg~ 1 ~ ~ H St P /4 .4.,* 4’ SN, h$ A 4., 4,f A QUALITATIVE ANALYSIS OF SUPERVISION IN SAC MINUTEMAN... QUALITATIVE ANALYSIS OF SUPERVISION IN Master’s Thesis SAC MINUTEMAN ICBM MAINTENANCE 4. PERFORMING o1. REPORT NUMBER 7. AUTNOR(s) S. CONTRACT OR GRANT...112-83 A QUALITATIVE ANALYSIS OF SUPERVISION IN SAC MINUTEMAN ICBM MAINTENANCE A Thesis Presented to the Faculty of the School of Systems and Logistics

  12. NEW CONCEPT FOR DETERMINING THE ORDERS OF SAC AND PC

    Institute of Scientific and Technical Information of China (English)

    Wei Baodian; Liu Dongsu; Ma Wenping; Wang Xinmei

    2004-01-01

    The autocorrelation of a Boolean function possesses the capability to reflect such characteristics as linear structure, Strict Avalanche Criterion(SAC) and Propagation Criterion(PC)of degree k. But it can do nothing in determining the order of SAC or PC. A calculating table for the autocorrelation is constructed in this paper so as to show what is beyond the autocorrelation and how the three cryptographic characteristics are exhibited. A deeper study on the calculating table in a similar way has helped us to develop a new concept, named as the general autocorrelation, to address efficiently the problem how to determine the orders of SAC and PC. The application on the Advanced Encryption Standard(AES) shows the SAC and PC characteristics of Boolean functions of AES S-box.

  13. Documentation for delivery of Star Tracker to SAC-C

    DEFF Research Database (Denmark)

    Kilsgaard, Søren; Thuesen, Gøsta; Riis, Troels;

    1999-01-01

    The documentation EIDP (End Item Data Package) describes all the tests which have been performed on the flight hardware of the Star Tracker for the Argentine, Danish and NASA satellite SAC-C.......The documentation EIDP (End Item Data Package) describes all the tests which have been performed on the flight hardware of the Star Tracker for the Argentine, Danish and NASA satellite SAC-C....

  14. The anuran vocal sac: a tool for multimodal signalling

    OpenAIRE

    STARNBERGER, IRIS; Preininger, Doris; Hödl, Walter

    2014-01-01

    Although in anurans the predominant mode of intra- and intersexual communication is vocalization, modalities used in addition to or instead of acoustic signals range from seismic and visual to chemical. In some cases, signals of more than one modality are produced through or by the anuran vocal sac. However, its role beyond acoustics has been neglected for some time and nonacoustic cues such as vocal sac movement have traditionally been seen as an epiphenomenon of sound production. The divers...

  15. Efficiency of lachrymal sac drainage in newborns with dacryocystocele

    Directory of Open Access Journals (Sweden)

    Sakovich V.N.

    2016-12-01

    Full Text Available The article represents results of treatment of 14 newborns with unilateral dacryocystocele. Patients age was 7.2±0.5 days. In 9 newborns (64.3% dacryocystocele was complicated with lachrymal sac phlegmon; in 5 children (35.7% any complications were absent. Drainage of lachrymal sac through the lower lachrymal canaliculus, instillation of antibiotics, systemic antibiotic therapy in case of phlegmon were performed in all the children. Lachrymal sac washing was performed with a solution of the antibiotic ofloxacin till clear fluid evacuation. If necessary the drainage was repeated in 10 days. The drainage of lachrymal sac was successful in all the patients. 2-3 weeks after the drainage probing of nasolachrymal duct was perfomed in 4 children (28.6% including those 3 with lacrymal sac phlegmon. In 71.4% regression of dacryocystocele occurred itself. Any complications and side effects were not observed. Positive effect of the drainage, according to the authors, can be explained so that dilatation of lachrymal canaliculus before the procedure allows to eliminate Rosenmьller valve stenosis and evacuation of fluid, mucus and pus, being breeding ground for microorganisms from lachrymal sac, promotes inflammation subsiding. Authors also recommend to pay attention on prenatal diagnosis of dacryocystocele, using ultrasound investigation in the 3rd trimester of pregnancy.

  16. A Demonstration of the System Assessment Capability (SAC) Rev. 1 Software for the Hanford Remediation Assessment Project

    Energy Technology Data Exchange (ETDEWEB)

    Eslinger, Paul W.; Kincaid, Charles T.; Nichols, William E.; Wurstner, Signe K.

    2006-11-06

    The System Assessment Capability (SAC) is a suite of interrelated computer codes that provides the capability to conduct large-scale environmental assessments on the Hanford Site. Developed by Pacific Northwest National Laboratory for the Department of Energy, SAC models the fate and transport of radioactive and chemical contaminants, starting with the inventory of those contaminants in waste sites, simulating transport through the environment, and continuing on through impacts to the environment and humans. Separate modules in the SAC address inventory, release from waste forms, water flow and mass transport in the vadose zone, water flow and mass transport in the groundwater, water flow and mass transport in the Columbia River, air transport, and human and ecological impacts. The SAC supports deterministic analyses as well as stochastic analyses using a Monte Carlo approach, enabling SAC users to examine the effect of uncertainties in a number of key parameters. The initial assessment performed with the SAC software identified a number of areas where both the software and the analysis approach could be improved. Since that time the following six major software upgrades have been made: (1) An air pathway model was added to support all-pathway analyses. (2) Models for releases from glass waste forms, buried graphite reactor cores, and buried naval reactor compartments were added. (3) An air-water dual-phase model was added to more accurately track the movement of volatile contaminants in the vadose zone. (4) The ability to run analyses was extended from 1,000 years to 10,000 years or longer after site closure. (5) The vadose zone flow and transport model was upgraded to support two-dimensional or three-dimensional analyses. (6) The ecological model and human risk models were upgraded so the concentrations of contaminants in food products consumed by humans are produced by the ecological model. This report documents the functions in the SAC software and provides a

  17. Applied Endoscopic Anatomical Evaluation of the Lacrimal Sac

    Directory of Open Access Journals (Sweden)

    Seyyed Mostafa Hashemi

    2015-05-01

    Full Text Available Introduction: Dacryocystorhinostomy (DCR, a popular surgical procedure, has been performed using an endoscopic approach over recent years. Excellent anatomical knowledge is required for this endoscopic surgical approach. This study was performed in order to better evaluate the anatomical features of the lacrimal apparatus from cadavers in the Isfahan forensic center as a sample of the Iranian population.   Materials and Methods: DCR was performed using a standard method on 26 cadaver eyes from the forensic center of Isfahan. The lacrimal sac was exposed completely, then the anatomical features of the lacrimal sac and canaliculus were measured using a specified ruler.   Results: A total of 26 male cadaveric eyes were used, of which four (16.7% were probably non-Caucasian. Two (8% of the eyes needed septoplasty, one (4% needed uncinectomy, and none needed turbinoplasty. Four (16% lacrimal sacs were anterior to axilla, one (4% was posterior and 20 (80% were at the level of the axilla of the middle turbinate. The distance  from the nasal sill to the anterior edge of the lacrimal sac (from its mid-height was 39.04 (±4.92 mm. The distance from the nasal sill to the posterior edge of the lacrimal sac (from its mid-height was 45.50 (±4.47 mm. The width and length of the lacrimal sac was 7.54 (±1.44 mm and 13.16 (±5.37 mm, respectively. The distance from the anterior edge of the lacrimal sac to the posterior edge of the uncinate process was 14.06 (±3.00 mm, while the distance from the anterior nasal spine to the anterior edge of the lacrimal sac (from its mid-height was 37.20 (±5.37 mm.The height of the fundus was 3.26 (±1.09 mm. The distance from the superior punctum to the fundus was 12.70 (±1.45 mm, and the distance from the inferior punctum to the fundus was 11.10 (±2.02 mm.   Conclusion:  Given the differences between the various studies conducted in order to evaluate the position of the lacrimal sac, studies such as this can help to

  18. von Hippel-Lindau disease: surveillance strategy for endolymphatic sac tumors

    DEFF Research Database (Denmark)

    Poulsen, Marie Louise Mølgaard; Gimsing, Steen; Kosteljanetz, Michael

    2011-01-01

    : Up to 16% of patients with the hereditary von Hippel-Lindau disease develop endolymphatic sac tumors of the inner ear. Early diagnosis and treatment of endolymphatic sac tumors can prevent audiovestibular morbidity, but optimal endolymphatic sac tumor surveillance strategy has yet...... to be determined. We aimed to evaluate endolymphatic sac tumor surveillance to determine the best surveillance strategy....

  19. Bifurcation Adds Flavor to Basketball

    CERN Document Server

    Min, Byeong June

    2016-01-01

    We report an emergence of bifurcation in basketball, a single-particle system governed by Newtonian mechanics. When shooting the basketball, the obvious control parameters are the launch speed and the launch angle. We propose to use the three-dimensional velocity phase-space volume associated with the given launch parameters to quantify the difficulty of the shooting. The optimal launch angle that maximizes the associated phase-space volume undergoes a bifurcation as the launch speed is increased, if the shooter is farther than a critical distance away from the hoop. Thus, the bifurcation makes it very important to control the launch speed accurately. If the air resistance is removed, the bifurcation disappears and the phase-space volume distribution becomes dispersionless and shrinks in magnitude.

  20. Functional blood flow patterns of the endolymphatic sac in the rat

    DEFF Research Database (Denmark)

    Friis, Morten; Qvortrup, Klaus

    2008-01-01

    Conclusion. Visualization of the endolymphatic sac vascular network under video fluorescence microscopy showed a typical microvascular organization. The microvascular arrangement and the microcirculation may reflect a functional state of the endolymphatic sac. Damage or change of the blood...... circulation following endolymphatic sac surgery is discussed. Objectives. To visualize and study the dynamic microcirculation of the endolymphatic sac in live rats. Method. An experimental animal study using in vivo video fluorescence microscopy. Results. Visualization of the endolymphatic sac vascular...

  1. An inguinal hernia sac tumor of extrahepatic cholangiocarcinoma origin

    Directory of Open Access Journals (Sweden)

    Yamazaki Hidehiro

    2006-03-01

    Full Text Available Abstract Background Metastatic hernia sac tumor from biliary malignancy is extremely rare with only one such case previously reported. We herein report an additional case of extrahepatic cholangiocarcinoma presenting as a hernia sac tumor. Case presentation A 78-year-old man presented with an irreducible right inguinal hernia associated with a firm tumor, 2.0 cm in diameter. A computed tomography scan demonstrated a soft tissue density mass with heterogeneous enhancement within the right inguinal canal. The patient underwent a hernia repair and the hernia sac tumor was resected. Histological examination of the tumor revealed a metastatic adenocarcinoma suggesting the tumor was of pancreato-biliary origin. Further investigation using imaging studies disclosed a primary tumor in the upper bile duct. The patient died of the disease nine months after the resection. Conclusion Hernia sac tumors should be considered when an irreducible, growing mass appears within an inguinal hernia. Computed tomography may be useful for the early detection of hernia sac tumors from undiagnosed intra-abdominal malignancies.

  2. The anuran vocal sac: a tool for multimodal signalling

    Science.gov (United States)

    Starnberger, Iris; Preininger, Doris; Hödl, Walter

    2014-01-01

    Although in anurans the predominant mode of intra- and intersexual communication is vocalization, modalities used in addition to or instead of acoustic signals range from seismic and visual to chemical. In some cases, signals of more than one modality are produced through or by the anuran vocal sac. However, its role beyond acoustics has been neglected for some time and nonacoustic cues such as vocal sac movement have traditionally been seen as an epiphenomenon of sound production. The diversity in vocal sac coloration and shape found in different species is striking and recently its visual properties have been given a more important role in signalling. Chemosignals seem to be the dominant communication mode in newts, salamanders and caecilians and certainly play a role in the aquatic life phase of anurans, but airborne chemical signalling has received less attention. There is, however, increasing evidence that at least some terrestrial anuran species integrate acoustic, visual and chemical cues in species recognition and mate choice and a few secondarily mute anuran species seem to fully rely on volatile chemical cues produced in glands on the vocal sac. Within vertebrates, frogs in particular are suitable organisms for investigating multimodal communication by means of experiments, since they are tolerant of disturbance by observers and can be easily manipulated under natural conditions. Thus, the anuran vocal sac might be of great interest not only to herpetologists, but also to behavioural biologists studying communication systems. PMID:25389375

  3. Inviting Calm Within: ADD, Neurology, and Mindfulness

    Science.gov (United States)

    Riner, Phillip S.; Tanase, Madalina

    2014-01-01

    The fourth edition of the "Diagnostic and Statistical Manual of Mental Disorders" ("DSM IV") describes ADD as behaviorally observed impairments in attention, impulsivity, and hyperactivity. Officially known as AD/HD, we use ADD here because we are dealing primarily with attention, organizational, and impulsivity issues. A more…

  4. Vascular development and hemodynamic force in the mouse yolk sac

    Directory of Open Access Journals (Sweden)

    Monica D Garcia

    2014-08-01

    Full Text Available Vascular remodeling of the mouse embryonic yolk sac is a highly dynamic process dependent on multiple genetic signaling pathways as well as biomechanical factors regulating proliferation, differentiation, migration, cell-cell and cell-matrix interactions. During this early developmental window, the initial primitive vascular network of the yolk sac undergoes a dynamic remodeling process concurrent with the onset of blood flow, in which endothelial cells establish a branched, hierarchical structure of large vessels and smaller capillary beds. In this review, we will describe the molecular and biomechanical regulators which guide vascular remodeling in the mouse embryonic yolk sac, as well as live imaging methods for characterizing endothelial cell and hemodynamic function in cultured embryos.

  5. On the implementation of SAC in target tracking loop

    Science.gov (United States)

    Rusnak, Ilan; Weiss, Haim

    2017-01-01

    The existing SAC architecture requires the knowledge of a model whose output is followed by the controlled system. This control architecture is suitable for motion control applications where the required trajectory of the controller plant is known. The Simple Adaptive Control (SAC) algorithm uses the input of a trajectory generator, its state and its output to drive the tracking error to zero. However, when tracking a target, e.g. by a radar, neither the target's "input", nor its state are available. Thus the existing SAC architecture cannot be implemented per se. The paper proposes that the model to be tracked is the estimated state model generated by the target state estimator/observer.

  6. Fast frequency hopping codes applied to SAC optical CDMA network

    Science.gov (United States)

    Tseng, Shin-Pin

    2015-06-01

    This study designed a fast frequency hopping (FFH) code family suitable for application in spectral-amplitude-coding (SAC) optical code-division multiple-access (CDMA) networks. The FFH code family can effectively suppress the effects of multiuser interference and had its origin in the frequency hopping code family. Additional codes were developed as secure codewords for enhancing the security of the network. In considering the system cost and flexibility, simple optical encoders/decoders using fiber Bragg gratings (FBGs) and a set of optical securers using two arrayed-waveguide grating (AWG) demultiplexers (DeMUXs) were also constructed. Based on a Gaussian approximation, expressions for evaluating the bit error rate (BER) and spectral efficiency (SE) of SAC optical CDMA networks are presented. The results indicated that the proposed SAC optical CDMA network exhibited favorable performance.

  7. Squamous cell carcinoma of the anal sac in five dogs.

    Science.gov (United States)

    Esplin, D G; Wilson, S R; Hullinger, G A

    2003-05-01

    Tumors of the perianal area of dogs are common and include multiple tumor types. Whereas perianal adenomas occur often, adenocarcinomas of the apocrine glands of the anal sac occur less frequently. A review of the literature revealed no reports of squamous cell carcinomas arising from the epithelial lining of the anal sac. Squamous cell carcinomas originating from the lining of the anal sac were diagnosed in five dogs. Microscopically, the tumors consisted of variably sized invasive nests and cords of epithelial cells displaying squamous differentiation. Four of the five dogs were euthanatized because of problems associated with local infiltration by the tumors. In the fifth dog, there was no evidence of tumor 7 months after surgical removal, but further follow up was not available.

  8. Adenoid cystic carcinoma of the lacrimal sac: case report

    Directory of Open Access Journals (Sweden)

    Antonio Ramos

    Full Text Available ABSTRACT Lacrimal sac tumors are rare with a clinical presentation that typically includes obstruction of the lacrimal drainage system and epiphora as the most frequent symptom. Cribriform adenoid cystic carcinoma (ACC is the most common malignant epithelial tumor of the lacrimal gland and minor salivary glands; however, its occurrence in the lacrimal drainage apparatus is extremely rare. Given the rarity of ACC, definitive diagnosis is almost invariably late conferring a poor prognosis. Herein we report the case of a 41-year-old woman with primary ACC of the lacrimal sac and describe the ophthalmological examination, diagnosis, and multidisciplinary treatment of this rare type of tumor.

  9. Sudden unilateral deafness with endolymphatic sac adenocarcinoma: MRI

    Energy Technology Data Exchange (ETDEWEB)

    Gaeta, M.; Blandino, A.; Minutoli, F.; Pandolfo, I. [Inst. of Radiological Sciences, Univ. of Messina (Italy)

    1999-10-01

    A 30-year-old man presented with sudden left deafness and vertigo. CT showed an osteolytic retrolabyrinthine tumour of the left temporal bone. High signal from the tumour and labyrinth was seen on fat-suppressed T 1-weighted images. At surgery, a haemorrhagic papillary-cystic adenocarcinoma of the endolymphatic sac was found. (orig.)

  10. Developmental aspects of the rat endolymphatic sac and functional implications.

    NARCIS (Netherlands)

    Peters, T.A.; Tonnaer, E.L.G.M.; Kuijpers, W.; Cremers, C.W.R.J.; Curfs, J.H.A.J.

    2001-01-01

    The purpose of this study was to determine specific characteristics of endolymphatic sac (ES) cells of the developing rat that are considered to be involved in endolymph homeostasis. Because intermediate filament proteins (IFPs) are regarded as markers of cell differentiation and basal lamina protei

  11. Inflamed appendix in a femoral hernial sac: de Garengeot's hernia.

    Science.gov (United States)

    Rajan, S S; Girn, H R S; Ainslie, W G

    2009-10-01

    Croissant de Garengeot's hernia is defined as the presence of an appendix in the femoral hernial sac. It is rare and occurs mostly in females. We report this hernia in a male patient along with the surgical management and review of literature.

  12. Southeast Economic Add-on 2004

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — To collect data on an angler's last trip for revealed preference models and economic valuation purposes. Typically done as an add-on to the MRIP intercept survey...

  13. Southeast Economic Add-on 2000

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — To collect data on an angler's last trip for revealed preference models and economic valuation purposes. Typically done as an add-on to the MRIP intercept survey...

  14. Southeast Economic Add-on 1997

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — To collect data on an angler's last trip for revealed preference models and economic valuation purposes. Typically done as an add-on to the MRIP intercept survey...

  15. Southeast Economic Add-on 2003

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — To collect data on an angler's last trip for revealed preference models and economic valuation purposes. Typically done as an add-on to the MRIP intercept survey and...

  16. Add Audio and Video to Your Site

    CERN Document Server

    MacDonald, Matthew

    2010-01-01

    Nothing spices up websites like cool sound effects (think ker-thunk as visitors press a button) or embedded videos. Think you need a programmer to add sizzle to your site? Think again. This hands-on guide gives you the techniques you need to add video, music, animated GIFs, and sound effects to your site. This Mini Missing Manual is excerpted from Creating a Web Site: The Missing Manual.

  17. 38 CFR Appendix A to Part 41 - Data Collection Form (Form SF-SAC)

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Data Collection Form (Form SF-SAC) A Appendix A to Part 41 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS.... Appendix A to Part 41—Data Collection Form (Form SF-SAC) Note: Data Collection Form SF-SAC and...

  18. Efficacy of Several Pesticide Products on Brown Widow Spider (Araneae: Theridiidae) Egg Sacs and Their Penetration Through the Egg Sac Silk.

    Science.gov (United States)

    Vetter, Richard S; Tarango, Jacob; Campbell, Kathleen A; Tham, Christine; Hayashi, Cheryl Y; Choe, Dong-Hwan

    2016-02-01

    Information on pesticide effects on spiders is less common than for insects; similar information for spider egg sacs is scarcer in the open literature. Spider egg sacs are typically covered with a protective silk layer. When pesticides are directly applied to egg sacs, the silk might prevent active ingredients from reaching the eggs, blocking their insecticidal effect. We investigated the impact of six water-based pesticide sprays and four oil-based aerosol products against egg sacs of brown widow spiders, Latrodectus geometricus C. L. Koch. All water-based spray products except one failed to provide significant mortality to egg sacs, resulting in successful spiderling emergence from treated egg sacs at a similar rate to untreated egg sacs. In contrast to water-based sprays, oil-based aerosols provided almost complete control, with 94-100% prevention of spiderling emergence. Penetration studies using colored pesticide products indicated that oil-based aerosols were significantly more effective in penetrating egg sac silk than were the water-based sprays, delivering the active ingredients on most (>99%) of the eggs inside the sac. The ability of pesticides to penetrate spider egg sac silk and deliver lethal doses of active ingredients to the eggs is discussed in relation to the chemical nature of egg sac silk proteins. Our study suggests that pest management procedures primarily relying on perimeter application of water-based sprays might not provide satisfactory control of brown widow spider eggs. Determination of the most effective active ingredients and carrier characteristics warrant further research to provide more effective control options for spider egg sacs.

  19. Endolymphatic sac tumor : a rare cerebellopontine angle tumor.

    Directory of Open Access Journals (Sweden)

    Joseph B

    2002-10-01

    Full Text Available Endolymphatic sac tumors (ELST are rare papillary tumors of the temporal bone. Previously named as aggressive papillary middle ear tumors, they have recently been shown to arise from the endolymphatic sac. They are a rare in cerebello-pontine angle (CPA. We present a case of an ELST who presented as a CPA tumor with hydrocephalus. He underwent a ventriculo-peritoneal shunt initially. On exploration of the CP angle, the tumor was found to be extremely vascular. He was re-explored following embolization, and a subtotal excision of the tumor was done. Extensive petrous bone infiltration and vascularity of the tumor makes total excision almost impossible with high risk of cranial nerve deficits, excessive blood loss and CSF leak. This tumor should be considered in the differential diagnosis of vascular CPA tumors which erode the petrous temporal bone. The relevant literature is reviewed.

  20. A clinicopathologic analysis of primary orbital yolk sac tumor

    Directory of Open Access Journals (Sweden)

    PENG Ji-ying

    2012-02-01

    Full Text Available Objective On rare occasions, yolk sac tumor may arise from extragonadal sites. Orbit is an unusual location for the primary development of this tumor. The presence of intracranial yolk sac tumor on biopsy always makes the diagnosis challenge for pathologists. Herein we report a case of intracranial primary yolk sac tumor in left orbital apex. The clinicopathology of this tumor and its differential diagnosis are discussed. Methods The clinical manifestation of a patient with primary yolk sac tumor occurring in left orbital apex was presented retrospectively. Resected orbital mass was routinely paraffin-embedded and stained with hematoxylin and eosin. Dako Envision immunohistochemical staining system was used to detect the tumor antigen expressions, including alpha-fetoprotein (AFP, cytokeratin, placental alkaline phosphatase (PLAP, CD30, CD34, CD45, CD99, CD117, synaptophysin (Syn and chromogranin A (CgA. Results A 2-year-old boy presented with 3-month history of ptosis of eyelid and exophthalmos on left eye. Magnetic resonance imaging (MRI scan revealed a lesion occupied the left orbital apex with infiltration of surrounding normal structure, including left posterior ethmoid sinus, the wall of left maxillary sinus and sphenoid. However, there was no evidence of tumor infiltrating in brain parenchyma. Craniotomy was performed and the tumor was removed by en bloc resection. Grossly, the biopsy specimen received in small pieces was 1.20 cm × 1.00 cm × 1.00 cm when aggregated. No fibrous capsule, necrosis, haemorrhage and gross calcification were found in the tissue fragments. Histological examination revealed that the tumor was arranged in a reticular pattern. The cells were relatively large with a clear cytoplasm and vesicular nuclei. Scattered mitotic figures were noted. Schiller-Duval bodies and periodic acid-Schiff (PAS positive (eosinophilic bodies were evident in the tumor tissue. Immunohistochemical staining showed that the tumor cells

  1. Distinct antigenic characteristics of murine parietal yolk sac laminin

    DEFF Research Database (Denmark)

    Wewer, U M; Tichy, D; Damjanov, A;

    1987-01-01

    Two monoclonal antibodies (LAM-A and LAM-B) specific for laminin from normal and neoplastic parietal yolk sac (PYS) cells were produced in rats immunized with a mouse yolk sac carcinoma cell line. Both antibodies immunoprecipitated the 400,000- and 200,000-Da chains of laminin and reacted...... with purified PYS laminin in ELISA. LAM-A reacted with mouse and rat PYS laminin, whereas LAM-B reacted only with mouse PYS laminin. Formaldehyde- and methanol-fixed adult and fetal somatic tissues were immunohistochemically unreactive with either of the two antibodies. In acetone-fixed tissue sections, both...... antibodies reacted weakly with some medullary tubules of the kidney, the follicular basement membrane of the ovaries, and the seminiferous tubules. The antibodies appear to react with the polypeptide determinants residing on the terminal portion of the long arm of laminin. It is concluded that laminin...

  2. Primary Yolk Sac Tumor of the Omentum: Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Baek, Chang Kyu; Oh, Young Taik; Jung, Dae Chul [Dept. of Radiology, Research Institue of Radiological Science, Yensei University College of Medicine, Seoul (Korea, Republic of); Bae, Yoon Sung [Dept. of Pathology, Yensei University College of Medicine, Seoul (Korea, Republic of)

    2012-01-15

    A 32-year-old woman had been referred to our hospital for lower abdominal pain. Pelvic ultrasonography and magnetic resonance imaging revealed a huge solid mass with an internal cystic portion. The patient underwent a staging laparotomy and subsequent total abdominal hysterectomy with bilateral salpingo-oophorectomy, bilateral pelvic lymph nodes sampling, and total omentectomy. At staging laparotomy, a large omental mass was found. The tumor displayed the typical histological patterns observed in the yolk sac tumor. The alpha-fetoprotein (AFP) serum value on the 10th day after surgery was 11,576.67 IU/mL and decreased to 6.46 IU/mL after chemotherapy. At the end of the treatment, all the findings, including the AFP level, were normal. We report a case of primary yolk sac tumor of the omentum in a 32-year-old woman.

  3. SacB-SacR gene cassette as the negative selection marker to suppress Agrobacterium overgrowth in Agrobacterium-mediated plant transformation

    Directory of Open Access Journals (Sweden)

    Yiming Liu

    2016-10-01

    Full Text Available Agrobacterium overgrowth is a common problem in Agrobacterium-mediated plant transfor-mation. To suppress the Agrobacterium overgrowth, various antibiotics have been used during plant tissue culture steps. The antibiotics are expensive and may adversely affect plant cell differentiation and reduce plant transformation efficiency. The SacB-SacR proteins are toxic to most Agrobacterium tumefaciens strains when they are grown on culture medium sup¬plemented with sucrose. Therefore, SacB-SacR genes can be used as negative selection markers to suppress the overgrowth of Agrobacterium tumefaciens in the plant tissue culture process. We generated a mutant Agrobacterium tumefaciens strain GV2260 (recA-SacB/R that has the SacB-SacR cassette inserted into the bacterial genome at the recA gene locus. The mutant Agrobacterium strain is sensitive to sucrose but maintains its ability to transform plant cells in both transient and stable transformation assays. We demonstrated that the mutant strain GV2260 (recA-SacB/R can be inhibited by sucrose that reduces the overgrowth of Agrobacterium and therefore improves the plant transformation efficiency. We employed GV2260 (recA-SacB/R to generate stable transgenic N. benthamiana plants expressing a CRISPR-Cas9 for knocking out a WRKY transcrip¬tion factor.

  4. Excited states of Ne isoelectronic ions: SAC-CI study

    Energy Technology Data Exchange (ETDEWEB)

    Das, A.K.; Ehara, M.; Nakatsuji, H. [Kyoto Univ. (Japan). Faculty of Engineering

    2001-02-01

    Excited states of the s, p, and d symmetries up to principal quantum number n = 4 are studied for the first eight members of Ne isoelectronic sequence (Ne to Cl{sup 7+}) by the SAC-CI (symmetry-adapted-cluster configuration-interaction) method. The valence STO basis sets of Clementi et al. and the optimized excited STO are used by the STO-6G expansion method. The calculated transition energies agree well with the experimental values wherever available. (orig.)

  5. Yolk sac tumor in a patient with transverse testicular ectopia

    Directory of Open Access Journals (Sweden)

    Zhu Yi-Ping

    2011-08-01

    Full Text Available Abstract Transverse testicular ectopia (TTE is a rare anomaly in which both testes descend through a single inguinal canal. We report a case of yolk sac tumor in the ectopic testis of a patient with TTE. A 24-year-old man presented to our hospital with a left inguinal-mass, right cryptorchidism and elevated alpha-fetoprotein (AFP. A left herniotomy 3 years earlier demonstrated both testes in the left scrotum, one above another positionally. Four months ago, a left scrotal mass appeared and radical orchiectomy of both testes revealed testicular yolk sac tumor of the ectopic testis. An enlarging left inguinal-mass appeared 2 months ago and he was referred to our hospital. Laboratory data showed an elevation of AFP (245.5 ng/ml and a 46 XY karyotype. He underwent bilateral retroperitoneal lymph node dissection and simultaneous left inguinal mass dissection. Histopathologic examination revealed a diagnosis of recurrent yolk sac tumor in the left inguinal mass. The retroperitoneal lymph node was not enlarged and, on histopathology, was not involved. The patient has now been followed up for 8 months without evidence of biochemical or radiological recurrence.

  6. Carcinoma of the anal sac glands in ranch mink.

    Science.gov (United States)

    Hadlow, W J

    1985-05-01

    During a 14-year period, carcinoma of the anal sac apocrine glands was found in 52 pastel and 8 sapphire mink (Mustela vison) kept for studies on slow viral diseases. The pastel mink varied in age from 72 to 135 months (mean age 108 months), the sapphire mink from 63 to 100 months (mean age 81 months). All but one pastel mink were females. The primary tumor varied in size from masses that caused bulges in the perineum to those that were found only after microscopic examination of the anal sac glands. Although the primary tumor grew mainly by expansion with little local infiltration, 41 of the 60 tumors had metastasized to the regional lymph nodes and sometimes also to more distant sites. The striking propensity of the carcinoma to metastasize while still small, even microscopic, often resulted in massive secondary growths, notably in the iliac lymph nodes. Hypercalcemia did not accompany the carcinoma. Its varied microscopic appearance included solid, glandular, squamous cell, and spindle or round cell components. Combinations of them formed mixed or complex histologic patterns, no doubt largely attributable to neoplastic proliferation of myoepithelial cells and squamous metaplasia of the apocrine gland epithelium. Although its cause remains obscure, the carcinoma appeared to arise from small foci of hyperplastic apocrine glands, sometimes in relation to both anal sacs. The tumor is a common and distinctive expression of neoplasia in older ranch mink.

  7. Allosteric Activation of the Phosphoinositide Phosphatase Sac1 by Anionic Phospholipids

    Science.gov (United States)

    2012-01-01

    Sac family phosphoinositide phosphatases comprise an evolutionarily conserved family of enzymes in eukaryotes. Our recently determined crystal structure of the Sac phosphatase domain of yeast Sac1, the founding member of the Sac family proteins, revealed a unique conformation of the catalytic P-loop and a large positively charged groove at the catalytic site. We now report a unique mechanism for the regulation of its phosphatase activity. Sac1 is an allosteric enzyme that can be activated by its product phosphatidylinositol or anionic phospholipid phosphatidylserine. The activation of Sac1 may involve conformational changes of the catalytic P-loop induced by direct binding with the regulatory anionic phospholipids in the large cationic catalytic groove. These findings highlight the fact that lipid composition of the substrate membrane plays an important role in the control of Sac1 function. PMID:22452743

  8. Apospory appears to accelerate onset of meiosis and sexual embryo sac formation in sorghum ovules

    Directory of Open Access Journals (Sweden)

    Elliott Estella

    2011-01-01

    Full Text Available Abstract Background Genetically unreduced (2n embryo sacs (ES form in ovules of gametophytic apomicts, the 2n eggs of which develop into embryos parthenogenetically. In many apomicts, 2n ES form precociously during ovule development. Whether meiosis and sexual ES formation also occur precociously in facultative apomicts (capable of apomictic and sexual reproduction has not been studied. We determined onset timing of meiosis and sexual ES formation for 569 Sorghum bicolor genotypes, many of which produced 2n ES facultatively. Results Genotype differences for onset timing of meiosis and sexual ES formation, relative to ovule development, were highly significant. A major source of variation in timing of sexual germline development was presence or absence of apomictic ES, which formed from nucellar cells (apospory in some genotypes. Genotypes that produced these aposporous ES underwent meiosis and sexual ES formation precociously. Aposporous ES formation was most prevalent in subsp. verticilliflorum and in breeding lines of subsp. bicolor. It was uncommon in land races. Conclusions The present study adds meiosis and sexual ES formation to floral induction, apomictic ES formation, and parthenogenesis as processes observed to occur precociously in apomictic plants. The temporally diverse nature of these events suggests that an epigenetic memory of the plants' apomixis status exists throughout its life cycle, which triggers, during multiple life cycle phases, temporally distinct processes that accelerate reproduction.

  9. Sac Angiography and Glue Embolization in Emergency Endovascular Aneurysm Repair for Ruptured Abdominal Aortic Aneurysm

    Energy Technology Data Exchange (ETDEWEB)

    Koike, Yuya, E-mail: r06118@hotmail.co.jp; Nishimura, Jun-ichi, E-mail: jun-ichi-n@nifty.com; Hase, Soichiro, E-mail: haseman@hotmail.co.jp; Yamasaki, Motoshige, E-mail: genyamasaki@gmail.com [Kawasaki Saiwai Hospital, Department of Interventional Radiology (Japan)

    2015-04-15

    PurposeThe purpose of this study was to demonstrate a sac angiography technique and evaluate the feasibility of N-butyl cyanoacrylate (NBCA) embolization of the ruptured abdominal aortic aneurysm (AAA) sac in emergency endovascular aneurysm repair (EVAR) in hemodynamically unstable patients.MethodsA retrospective case series of three patients in whom sac angiography was performed during emergency EVAR for ruptured AAA was reviewed. After stent graft deployment, angiography within the sac of aneurysm (sac angiography) was performed by manually injecting 10 ml of contrast material through a catheter to identify the presence and site of active bleeding. In two patients, sac angiography revealed active extravasation of the contrast material, and NBCA embolization with a coaxial catheter system was performed to achieve prompt sealing.ResultsSac angiography was successful in all three patients. In the two patients who underwent NBCA embolization for aneurysm sac bleeding, follow-up computed tomography (CT) images demonstrated the accumulation of NBCA consistent with the bleeding site in preprocedural CT images.ConclusionsEVAR is associated with a potential risk of ongoing bleeding from type II or IV endoleaks into the disrupted aneurysm sac in patients with severe coagulopathy. Therefore, sac angiography and NBCA embolization during emergency EVAR may represent a possible technical improvement in the treatment of ruptured AAA in hemodynamically unstable patients.

  10. Innate immune defense in the inner ear - mucines are expressed by the human endolymphatic sac

    DEFF Research Database (Denmark)

    Møller, Martin N; Kirkeby, Svend; Cayé-Thomasen, Per

    2017-01-01

    system, the potential expression of members of the important mucin family has not been detailed. Thus, this paper explores endolymphatic sac expression of a number of mucins and mucin precursors. Twelve fresh tissue samples from the human endolymphatic sac were obtained during translabyrinthine surgery....... The expression of Mucin 1, 2, 5B/AC and 16, as well as the core structure elements (mucin precursors) T-antigen, Tn-antigen and Sialyl-Tn-antigen was investigated by immunohistochemistry. The endolymphatic sac epithelium expressed MUC1 (both apically towards the endolymphatic sac (ES) lumen and basally towards...... the capillary network), MUC 16 and Tn-antigen. There was no labeling after incubation with antibodies against T-antigen, sialyl-Tn-antigen, MUC2 and MUC5B/AC. We conclude that the human endolymphatic sac epithelium expresses a number of mucin molecules, which supports the hypothesis of the sac as the primary...

  11. Glucocorticoid and progesterone receptors in yolk sac placenta.

    Science.gov (United States)

    Carbone, J P; Baldridge, R C; Magen, A B; Andrew, C L; Koszalka, T R; Brent, R L

    1986-01-01

    The parietal yolk sac (PYS) of the rat fetus at the 14th day of gestation contains glucocorticoid as well as progesterone receptors; both are present in the trophoblast cell layer. Following heat activation the receptors are capable of binding to deoxyribonucleic acid- (DNA-)cellulose. Glucocorticoid receptors, but not progesterone receptors, are also present in the visceral yolk sac (VYS) at the 14th day of gestation. Greater amounts (some 250 femtomoles/mg cytosol protein) of a glucocorticoid receptor are present in the VYS on the 17th day of gestation. The Kd is approximately 4 X 10(-9) M; following activation it also binds to DNA-cellulose. The elution pattern of the activated VYS receptor from diethylaminoethyl-(DEAE-)Sephadex, however, is similar to that found with kidney and colon rather than that of liver (i.e., it resembles corticosteroid binder IB rather than binder II) indicating a possible role in transport. Although the receptors are separate entities, progesterone competes as effectively as corticosterone for binding to the glucocorticoid receptors in both the PYS and and VYS, thus raising the question of the possible effect of changes in progesterone concentrations on the functioning of glucocorticoids during development.

  12. The PIKfyve–ArPIKfyve–Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines

    Energy Technology Data Exchange (ETDEWEB)

    Ikonomov, Ognian C., E-mail: oikonomo@med.wayne.edu; Filios, Catherine, E-mail: cfilios@med.wayne.edu; Sbrissa, Diego, E-mail: dsbrissa@med.wayne.edu; Chen, Xuequn, E-mail: xchen@med.wayne.edu; Shisheva, Assia, E-mail: ashishev@med.wayne.edu

    2013-10-18

    Highlights: •We assess PAS complex proteins and phosphoinositide levels in breast cancer cells. •Sac3 and ArPIKfyve are markedly elevated in triple-negative breast cancer cells. •Sac3 silencing inhibits proliferation in triple-negative breast cancer cell lines. •Phosphoinositide profiles are altered in breast cancer cells. •This is the first evidence linking high Sac3 with breast cancer cell proliferation. -- Abstract: The phosphoinositide 5-kinase PIKfyve and 5-phosphatase Sac3 are scaffolded by ArPIKfyve in the PIKfyve–ArPIKfyve–Sac3 (PAS) regulatory complex to trigger a unique loop of PtdIns3P–PtdIns(3,5)P{sub 2} synthesis and turnover. Whereas the metabolizing enzymes of the other 3-phosphoinositides have already been implicated in breast cancer, the role of the PAS proteins and the PtdIns3P–PtdIns(3,5)P{sub 2} conversion is unknown. To begin elucidating their roles, in this study we monitored the endogenous levels of the PAS complex proteins in cell lines derived from hormone-receptor positive (MCF7 and T47D) or triple-negative breast cancers (TNBC) (BT20, BT549 and MDA-MB-231) as well as in MCF10A cells derived from non-tumorigenic mastectomy. We report profound upregulation of Sac3 and ArPIKfyve in the triple negative vs. hormone-sensitive breast cancer or non-tumorigenic cells, with BT cell lines showing the highest levels. siRNA-mediated knockdown of Sac3, but not that of PIKfyve, significantly inhibited proliferation of BT20 and BT549 cells. In these cells, knockdown of ArPIKfyve had only a minor effect, consistent with a primary role for Sac3 in TNBC cell proliferation. Intriguingly, steady-state levels of PtdIns(3,5)P{sub 2} in BT20 and T47D cells were similar despite the 6-fold difference in Sac3 levels between these cell lines. However, steady-state levels of PtdIns3P and PtdIns5P, both regulated by the PAS complex, were significantly reduced in BT20 vs. T47D or MCF10A cell lines, consistent with elevated Sac3 affecting directly or

  13. Conjunctival sac bacterial flora isolated prior to cataract surgery

    Directory of Open Access Journals (Sweden)

    Suto C

    2012-01-01

    Full Text Available Chikako Suto1,2, Masahiro Morinaga1,2, Tomoko Yagi1,2, Chieko Tsuji3, Hiroshi Toshida41Department of Ophthalmology, Saiseikai Kurihashi Hospital, Saitama; 2Department of Ophthalmology, Tokyo Women's Medical University, Tokyo; 3Department of Clinical Laboratory, Saiseikai Kurihashi Hospital, Saitama; 4Department of Ophthalmology, Juntendo University Shizuoka Hospital, Izunokuni, Shizuoka, JapanObjective: To determine the trends of conjunctival sac bacterial flora isolated from patients prior to cataract surgery.Subjects and methods: The study comprised 579 patients (579 eyes who underwent cataract surgery. Specimens were collected by lightly rubbing the inferior palpebral conjunctival sac with a sterile cotton swab 2 weeks before surgery, and then cultured for isolation of bacteria and antimicrobial sensitivity testing. The bacterial isolates and percentage of drug-resistant isolates were compared among age groups and according to whether or not patients had diabetes mellitus, hyperlipidemia, dialysis therapy, oral steroid use, dry eye syndrome, or allergic conjunctivitis.Results: The bacterial isolation rate was 39.2%. There were 191 strains of Gram-positive cocci, accounting for the majority of all isolates (67.0%, among which methicillin-sensitive coagulase-negative staphylococci was the most frequent (127 strains, 44.5%, followed by methicillin-resistant coagulase-negative staphylococci (37 strains, 12.7%. All 76 Gram-positive bacillary isolates (26.7% were from the genus Corynebacterium. Among the 16 Gram-negative bacillary isolates (5.9%, the most frequent was Escherichia coli (1.0%. The bacterial isolation rate was higher in patients >60 years old, and was lower in patients with dry eye syndrome, patients under topical treatment for other ocular disorders, and patients with hyperlipidemia. There was no significant difference in bacterial isolation rate with respect to the presence/absence of diabetes mellitus, steroid therapy, dialysis, or

  14. Vienna SAC-SOS: Analysis of the European VLBI Sessions

    Science.gov (United States)

    Ros, C. T.; Pavetich, P.; Nilsson, T.; Böhm, J.; Schuh, H.

    2012-12-01

    The Institute of Geodesy and Geophysics (IGG) of the Vienna University of Technology as an IVS Special Analysis Center for Specific Observing Sessions (SAC-SOS) has analyzed the European VLBI sessions using the software VieVS. Between 1990 and 2011, 115 sessions have been carried out. The analyzed baselines have lengths ranging from approximately 445 to 4580 km, and they show good repeatabilities, apart from the ones containing station Simeiz. The station velocities have also been investigated. The stations situated in the stable part of Europe have not shown significant relative movements w.r.t. Wettzell, whereas the stations located in the northern areas have the largest vertical motions as a result of the post glacial isostatic rebound of the zone. The stations placed in Italy, around the Black Sea, in Siberia, and near the Arctic Circle show the largest relative horizontal motions because they belong to different geodynamical units.

  15. Expression of histamine receptors in the human endolymphatic sac

    DEFF Research Database (Denmark)

    Møller, M Nue; Kirkeby, S; Vikeså, J.

    2016-01-01

    in 2012. This leaves betahistine (Betaserc) as the only drug for potential prevention of the incapacitating attacks of dizziness, tinnitus and hearing loss. However, the histamine receptors targeted by betahistine have never been demonstrated in the human ES. Accordingly, this study aims to investigate...... the expression of histamine receptors of the human ES epithelium and sub-epithelial stroma. Following sampling of human endolymphatic sac tissue during translabyrinthine surgery, the expression of histamine receptor genes was determined by cDNA microarray analysis. Results were subsequently verified by immuno......-histochemistry. The combined results of microarrays and immuno-histochemistry showed expression of the histamine receptor HRH1 in the epithelial lining of the ES, whereas HRH3 was expressed exclusively in the sub-epithelial capillary network. Receptors HRH2 and -4 were not expressed. The present data provide the first direct...

  16. How do Innovation Intermediaries add Value?

    DEFF Research Database (Denmark)

    Tran, Yen; Hsuan, Juliana; Mahnke, Volker

    2011-01-01

    Innovation intermediaries are increasingly being used in practice, but there is little concrete theoretical guidance on when and how they add value to client's new product development (NPD) processes. This paper develops propositions on innovation intermediaries value-added based on a detailed case...... types of specific intermediary capabilities (best-cost capabilities, timing-capabilities, market-response capabilities, and product solution capabilities) increases value added in clients' NDP processes....... study of an innovation intermediary's relations to three major clients in the European apparel fashion industry. We identify key contingencies to an innovation intermediary's value added (e.g. NDP speed and complexity of involvement). We also suggest a framework that specifies when a combination of four...

  17. Using Joint Interviews to Add Analytic Value.

    Science.gov (United States)

    Polak, Louisa; Green, Judith

    2016-10-01

    Joint interviewing has been frequently used in health research, and is the subject of a growing methodological literature. We review this literature, and build on it by drawing on a case study of how people make decisions about taking statins. This highlights two ways in which a dyadic approach to joint interviewing can add analytic value compared with individual interviewing. First, the analysis of interaction within joint interviews can help to explicate tacit knowledge and to illuminate the range of often hard-to-access resources that are drawn upon in making decisions. Second, joint interviews mitigate some of the weaknesses of interviewing as a method for studying practices; we offer a cautious defense of the often-tacit assumption that the "naturalness" of joint interviews strengthens their credibility as the basis for analytic inferences. We suggest that joint interviews are a particularly appropriate method for studying complex shared practices such as making health decisions.

  18. Involvement of Sac1 phosphoinositide phosphatase in the metabolism of phosphatidylserine in the yeast Saccharomyces cerevisiae.

    Science.gov (United States)

    Tani, Motohiro; Kuge, Osamu

    2014-04-01

    Sac1 is a phosphoinositide phosphatase that preferentially dephosphorylates phosphatidylinositol 4-phosphate. Mutation of SAC1 causes not only the accumulation of phosphoinositides but also reduction of the phosphatidylserine (PS) level in the yeast Saccharomyces cerevisiae. In this study, we characterized the mechanism underlying the PS reduction in SAC1-deleted cells. Incorporation of (32) P into PS was significantly delayed in sac1∆ cells. Such a delay was also observed in SAC1- and PS decarboxylase gene-deleted cells, suggesting that the reduction in the PS level is caused by a reduction in the rate of biosynthesis of PS. A reduction in the PS level was also observed with repression of STT4 encoding phosphatidylinositol 4-kinase or deletion of VPS34 encoding phophatidylinositol 3-kinase. However, the combination of mutations of SAC1 and STT4 or VPS34 did not restore the reduced PS level, suggesting that both the synthesis and degradation of phosphoinositides are important for maintenance of the PS level. Finally, we observed an abnormal PS distribution in sac1∆ cells when a specific probe for PS was expressed. Collectively, these results suggested that Sac1 is involved in the maintenance of a normal rate of biosynthesis and distribution of PS.

  19. Endolymphatic Sac Surgery for Ménière's Disease – Current Opinion and Literature Review

    Science.gov (United States)

    Flores García, Maria de Lourdes; Llata Segura, Carolina de la; Cisneros Lesser, Juan Carlos; Pane Pianese, Carlo

    2017-01-01

    Introduction The endolymphatic sac is thought to maintain the hydrostatic pressure and endolymph homeostasis for the inner ear, and its dysfunction may contribute to the pathophysiology of Ménière's disease. Throughout the years, different surgical procedures for intractable vertigo secondary to Ménière's disease have been described, and though many authors consider these procedures as effective, there are some who question its long-term efficacy and even those who think that vertigo control is achieved more due to a placebo effect than because of the procedure itself. Objective To review the different surgical procedures performed in the endolymphatic sac for the treatment of Ménière's disease. Data Sources PubMed, MD consult and Ovid-SP databases. Data Synthesis We focus on describing the different surgical procedures performed in the endolymphatic sac, such as endolymphatic sac decompression, endolymphatic sac enhancement, endolymphatic sac shunting and endolymphatic duct blockage, their pitfalls and advantages, their results in vertigo control and the complication rates. The senior author also describes his experience after 30 years of performing endolymphatic sac surgery. Conclusions The endolymphatic sac surgery, with all its variants, is a good option for patients with incapacitating endolymphatic hydrops, providing a high percentage of vertigo control and hearing preservation. PMID:28382128

  20. Megasporogenesis and development of the embryo sac in the Palestine variety of Trifolium alexandrinum L.

    Directory of Open Access Journals (Sweden)

    S. Krupko

    2015-01-01

    Full Text Available The structure and development of the embryo sac in Trifolium alexandrinum (Palestine variety, are very similar to that in Trifolium pratense. The embryo sac of Trifolium alexandrinum is monosporal, has eight nuclei and is of the Polygonum type. The Palestine variety of Trifolium alexandrinum can be autogamous.

  1. Gene expression demonstrates an immunological capacity of the human endolymphatic sac

    DEFF Research Database (Denmark)

    Møller, Martin Nue; Kirkeby, Svend; Vikeså, Jonas

    2015-01-01

    OBJECTIVES/HYPOTHESIS: The purpose of the present study is to explore, demonstrate, and describe the expression of genes related to the innate immune system in the human endolymphatic sac. It is hypothesized that the endolymphatic sac has a significant immunological function in the human inner ear....... STUDY DESIGN: DNA microarrays and immunohistochemistry were used for analyses of fresh human endolymphatic-sac tissue samples. METHODS: Twelve tissue samples from the human endolymphatic sac were obtained during translabyrinthine surgery for vestibular schwannoma. Microarray technology was used...... was obtained. Multiple key elements of both the cellular and humoral innate immune system were expressed, including Toll-like receptors 4 and 7, as well as beta-defensin and lactoferrin. CONCLUSIONS: The present data provides the first direct evidence of an immunological capacity of the human endolymphatic sac...

  2. Embryo sac development in some South African cultivars of Lantana camara

    Directory of Open Access Journals (Sweden)

    J. J. Spies

    1982-12-01

    Full Text Available Twenty embryo sacs from each of 20 different  Lantana camara L. cultivars naturalized in South Africa were examined. The normal sexual embryo sacs were monosporic 8-nucleated embryo sacs of the polygonum type and were encountered in 55% of the material examined. Several deviations from this pattern were recorded. Occasionally one of the nuclei failed to develop into a synergid, resulting in three polar nuclei. Contrary to published information, the antipodal cells did not increase in size, nor was there an increase in the number of nuclei per cell. Although the occurrence of sexuality is confirmed, no definite evidence exists for the occurrence of apomixis. The occurrence of two embryo sacs per locule might be the result of either apospory or of sexuality whereby two embryo sacs were formed from two megaspores.

  3. Laminin, a noncollagenous component of epithelial basement membranes synthesized by a rat yolk sac tumor

    DEFF Research Database (Denmark)

    Wewer, U; Albrechtsen, R; Ruoslahti, E

    1981-01-01

    Laminin, a glycoprotein antigenically similar or identical to a component of epithelial basement membranes, was identified as a major component of the abundant extracellular matrix synthesized by an experimentally induced rat yolk sac tumor. Immunocytochemical staining revealed laminin in cultured...... polypeptides with molecular weights of approximately 200,000 and 400,000. These comigrated with the polypeptides of mouse laminin isolated previously. The yolk sac tumor tissue grown in vivo contained laminin in the tumor cells and in the extracellular material as evidenced by immunofluorescence...... membranes in rat tissues in a manner indistinguishable from antilaminin. The presence of laminin in rat yolk sac cells, the presumed origin of our yolk sac tumor, was studied in some detail. Laminin was found to be present in normal cells of the visceral as well as the parietal yolk sac layer...

  4. Development of the endolymphatic sac in chick embryos, with reference to the degradation of otoconia

    Science.gov (United States)

    Yoshihara, T.; Kaname, H.; Narita, N.; Ishii, T.; Igarashi, M.; Fermin, C. D.

    1992-01-01

    The endolymphatic sac of chick embryos (from embryonic day 7 to 1-day-old chicks) was studied light- and electron-microscopically. At stage 30-31 (embryonic day 7-7.5), the epithelial cells of the endolymphatic sac were cuboidal to columnar in shape. Microvilli were relatively well developed. The intercellular space was wide. In the endolymphatic space of the endolymphatic sac, varying shapes and sizes of otoconia-like bodies were often observed. Intracytoplasmic phagosomes containing these bodies were rarely found. After stage 37 (embryonic day 11), otoconia-like bodies in the endolymphatic sac decreased in number and size. They were almost the same as the otoconia in the macular organs, ultrastructurally. These findings indicate that the endolymphatic sac of the chick embryos may possess the function of otoconial degradation and removal of calcium from otoconia.

  5. A Need to Know: The Role of Air Force Reconnaissance in War Planning, 1945 - 1953

    Science.gov (United States)

    1991-01-01

    machine painted so as to reduce its visibility against the sky. 2 Webster and Frankland, The Strategic Air Offensive Against Germany 1939-1945, vol. 1...Telegram, CG SAC/ XRAY / TOKYO JAPAN to CG SAC OFFUTT AFB OMAHA NEB, 9 [June 19511, File number: B-11929, Box 8-198, LeMay Papers, LOC. Ccmmander in...Papers of Curtis E. LeMay. LOC. CG SAC/ XRAY /TOKYO JAPAN to CG SAC OFFUTT AFB OMAHA NEB, 9 [June 19511. File number: B-11929. Box B-198. Papers of

  6. Support to Aviation Control Service (SACS: an online service for near real-time satellite monitoring of volcanic plumes

    Directory of Open Access Journals (Sweden)

    H. Brenot

    2013-10-01

    Full Text Available Volcanic eruptions emit plumes of ash and gases in the atmosphere, potentially at very high altitudes. Ash rich plumes are hazardous for airplanes as ash is very abrasive and easily melts inside their engines. With more than 50 active volcanoes per year and the ever increasing number of commercial flights, the safety of airplanes is a real concern. Satellite measurements are ideal for monitoring global volcanic activity and, in combination with atmospheric dispersion models, to track and forecast volcanic plumes. Here we present the Support to Aviation Control Service (SACS, http://sacs.aeronomie.be, which is a free online service initiated by ESA for the near real-time (NRT satellite monitoring of volcanic plumes of SO2 and ash. It combines data from two UV-visible (OMI, GOME-2 and two infrared (AIRS, IASI spectrometers. This new multi-sensor warning system of volcanic plumes, running since April 2012, is based on the detection of SO2 and is optimised to avoid false alerts while at the same time limiting the number of notifications in case of large plumes. The system shows successful results with 95% of our notifications corresponding to true volcanic activity.

  7. Molecular detection and in vitro antioxidant activity of S-allyl-L-cysteine (SAC) extracted from Allium sativum.

    Science.gov (United States)

    Sun, Y-E; Wang, W-D

    2016-06-30

    It is well known that Allium sativum has potential applications to clinical treatment of various cancers due to its remarkable ability in eliminating free radicals and increasing metabolism. An allyl-substituted cysteine derivative - S-allyl-L-cysteine (SAC) was separated and identified from Allium sativum. The extracted SAC was reacted with 1-pyrenemethanol to obtain pyrene-labelled SAC (Py-SAC) to give SAC fluorescence properties. Molecular detection of Py-SAC was conducted by steady-state fluorescence spectroscopy and time-resolved fluorescence method to quantitatively measure concentrations of Py-SAC solutions. The ability of removing 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radical using Py-SAC was determined through oxygen radical absorbance capacity (ORAC). Results showed the activity of Py-SAC and Vitamin C (VC) with ORAC as index, the concentrations of Py-SAC and VC were 58.43 mg/L and 5.72 mg/L respectively to scavenge DPPH, and 8.16 mg/L and 1.67 mg/L to scavenge •OH respectively. Compared with VC, the clearance rates of Py-SAC to scavenge DPPH were much higher, Py-SAC could inhibit hydroxyl radical. The ability of removing radical showed a dose-dependent relationship within the scope of the drug concentration.

  8. Invagination of the hernial sac stump. Technique for repair of inguinal hernia.

    Science.gov (United States)

    Shafik, A

    1980-09-01

    A technique for repair of indirect inguinal hernia is presented. The hernial sac stump is invaginated in an attempt to secure high ligation of the sac and obliterate any residual peritoneal diverticulum. Four hundred forty-two patients were operated on. The technique consists essentially of division of the internal spermatic fascial tube at the neck as well as embedding of the sac stump by purse-string sutures in a narrow neck of Lembert sutures in a wide neck. The defect in the fascia transversalis is closed over the stump. Three hundred eighty-one patients were followed up 2 to 15 years, with a recurrence rate of 1.6 percent. The concept that in indirect hernia the problem involves the sac rather than the defect is put forward. Recurrence results essentially from the existence of a handmade sac rather than an improperly repaired defect. The role of invagination of the sac in securing complete excision of the sac and proper closure of the defect is discussed. In initiating recurrence, the part played by the redundant peritoneum deep to the internal ring is emphasized. Changes in the dynamics of intraabdominal tension induced by stump embedding are explained.

  9. 40 CFR 63.3556 - How do I establish the emission capture system and add-on control device operating limits during...

    Science.gov (United States)

    2010-07-01

    ... system and add-on control device operating limits during the performance test? 63.3556 Section 63.3556... of key parameters of the valve operating system (e.g., solenoid valve operation, air pressure.../outlet Concentration Option § 63.3556 How do I establish the emission capture system and add-on...

  10. XPS of oxygen atoms on Ag(111) and Ag(110) surfaces: accurate study with SAC/SAC-CI combined with dipped adcluster model.

    Science.gov (United States)

    Ishikawa, Atsushi; Nakatsuji, Hiroshi

    2013-08-01

    O1s core-electron binding energies (CEBE) of the atomic oxygens on different Ag surfaces were investigated by the symmetry adapted cluster-configuration interaction (SAC-CI) method combined with the dipped adcluster model, in which the electron exchange between bulk metal and adsorbate is taken into account properly. Electrophilic and nucleophilic oxygens (O(elec) and O(nuc)) that might be important for olefin epoxidation in a low-oxygen coverage condition were focused here. We consider the O1s CEBE as a key property to distinguish the surface oxygen states, and series of calculation was carried out by the Hartree-Fock, Density functional theory, and SAC/SAC-CI methods. The experimental information and our SAC/SAC-CI results indicate that O(elec) is the atomic oxygen adsorbed on the fcc site of Ag(111) and that O(nuc) is the one on the reconstructed added-row site of Ag(110) and that one- and two-electron transfers occur, respectively, to the O(elec) and O(nuc) adclusters from the silver surface.

  11. Age and egg-sac loss determine maternal behaviour and locomotor activity of wolf spiders (Araneae, Lycosidae).

    Science.gov (United States)

    Ruhland, Fanny; Chiara, Violette; Trabalon, Marie

    2016-11-01

    Wolf spiders' (Lycosidae) maternal behaviour includes a specific phase called "egg brooding" which consists of guarding and carrying an egg-sac throughout the incubation period. The transport of an egg-sac can restrict mothers' exploratory and locomotor activity, in particular when foraging. The present study details the ontogeny of maternal behaviour and assesses the influence of age of egg-sac (or embryos' developmental stage) on vagrant wolf spider Pardosa saltans females' exploration and locomotion. We observed these spiders' maternal behaviour in the laboratory and evaluated their locomotor activity using a digital activity recording device. Our subjects were virgin females (without egg-sac) and first time mothers (with her egg-sac) who were divided into three groups. The first group of mothers were tested on the day the egg-sac was built (day 0), and the females of the other two groups were tested 10 or 15days after they had built their egg-sac. We evaluated the effects of the presence and the loss of egg-sac on mothers' activity. Pardosa saltans females' behaviour depended on mothers' physiological state and/or age of egg-sac (developmental stage of embryos). Virgin females' behaviour was not modified by the presence of an egg-sac in their environment. Mothers' reactions to the presence, the loss and the recovery of their egg-sac varied during the maternal cycle. Maternal behaviour changed with age of egg-sac, but the levels of locomotor activity of mothers with egg-sacs was similar to those of virgin females. Loss of egg-sac modified the maternal behaviour and locomotor activity of all mothers; these modifications were greater on "day 15" when embryos had emerged from eggs. All mothers were able to retrieve their egg-sacs and to re-attach them to their spinnerets.

  12. SAC-OCDM/TDM system for upgrading the TDM PON

    Institute of Scientific and Technical Information of China (English)

    He Chen; Shilin Xiao; Lilin Yi; Yi Dong; Weisheng Hu

    2011-01-01

    A spectral amplitude coded-optical code division multiplexing time division multiplexing (SAC-OCDM/TDM) passive optical network (PON) for upgrading the traditional TDM PON is proposed. To the best of our knowledge, our work is the first to report on the use of both spectral and orthogonal code domains, which are transparent to optical network unit (ONU) for hybrid PON, in order to upgrade TDM PON seamlessly. The fewer encoder/decoders and cheaper optical source under the conditions of high bite rate and large ONU accommodation make the system cost-effective. A downstream experiment is demonstrated, and the results demonstrate that the proposed system is feasible.%A spectral amplitude coded-optical code division multiplexing time division multiplexing (SACOCDM/TDM) passive optical network (PON) for upgrading the traditional TDM PON is proposed.To the best of our knowledge,our work is the first to report on the use of both spectral and orthogonal code domains,which are transparent to optical network unit (ONU) for hybrid PON,in order to upgrade TDM PON seamlessly.The fewer encoder/decoders and cheaper optical source under the conditions of high bite rate and large ONU accommodation make the system cost-effective.A downstream experiment is demonstrated,and the results demonstrate that the proposed system is feasible.The time division multiplexing (TDM) technique is used in the Ethernet passive optical network (EPON) and Gigabit passive optical network (GPON),which is currently used commercially and performs optimally.Nextgeneration broadband access networks are a new topic.Therefore,whether there is a need to upgrade directly the bit rates,of EPON and GPON or to introduce new techniques in passive optical network (PON) remains to be elucidated.

  13. Endovascular conversion with femorofemoral bypass as a treatment of endotension and aneurysm sac enlargement.

    Science.gov (United States)

    Smith, Stephen T; Clagett, G Patrick; Arko, Frank R

    2007-02-01

    We report a case of a patient treated with a Gore Excluder endograft for AAA in November 2003 with subsequent aneurysm sac enlargement in the absence of an identified endoleak. The patient had a Type I endoleak treated with a Palmaz stent at the neck and later developed a Type II endoleak treated with translumbar coil embolization. This was successful with absence of pressure in the sac after the procedure and stable aneurysm size over the next nine months. Surveillance of the patient with both CT and ultrasound then revealed an increase in the aortic sac diameter in the absence of endoleak. A Cook Zenith converter was used to reline this PTFE endograft. Subsequently, imaging showed aneurysm sac shrinkage. This is a report of endotension with aneurysm expansion following Gore Excluder placement which was treated successfully with a dacron endograft.

  14. Coagulopathy associated with sac reperfusion for reversing paraplegia after endovascular repair of type II thoracoabdominal aneurysm.

    Science.gov (United States)

    Lioupis, Christos; Katsanos, Konstantinos; Clough, Rachel; Matharu, Nick; Modarai, Bijan; Carrell, Tom; Taylor, Peter

    2013-11-01

    Sac perfusion may be helpful in preventing or reversing spinal cord injury after endovascular repair of thoracoabdominal aneurysms and it has been used as an adjunct to the standard physiologic measures of sustained hypertension and cerebrospinal fluid drainage. Coagulopathy as a result of endoleak after endovascular aneurysm repair has been reported, and very rare cases of treatment after repair of these endoleaks have been described. We report a 73-year-old man who had endovascular repair of a type II thoracoabdominal aneurysm with a branched stent graft. Sac reperfusion was initiated to manage postoperative paraplegia. The paraplegia partially resolved but severe hemorrhagic complications developed that were attributed to sac perfusion-related hyperfibrinolysis. Discontinuation of sac perfusion resolved the coagulopathy but resulted in paraplegia.

  15. Tarlov Cyst Is Correlated with a Short Broad Terminal of the Thecal Sac.

    Science.gov (United States)

    Xie, Chaoran; Zheng, Xuesheng; Zhang, Nu

    2016-12-27

    Background In clinical practice, we noted that the end section of the thecal sac is apparently different in patients with Tarlov cyst compared with that of the normal population. We conducted this clinical study based on magnetic resonance imaging (MRI). Methods Our study included 30 patients with Tarlov cyst and 30 healthy volunteers as the control. The L4, L5 cross-section areas, the L4, L5 anteroposterior diameters, and the terminal length of the thecal sac were measured from the lumbosacral spine MRI. Results The L4, L5 cross-section areas and the L4, L5 anteroposterior diameters are larger for the Tarlov cyst patients than the controls, but the terminal length of the thecal sac is shorter. Conclusion The Tarlov cyst is correlated with a short broad end of the thecal sac. Possibly, this anatomical variant is a causative factor of Tarlov cyst.

  16. Histological and Histochemical Analyses of the Cuttlebone Sac of the Golden Cuttlefish Sepia esculenta

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The secretion function of mantle is closely related to shell formation in some bivalves and gastropods. Up to now, few researches have been reported for cuttlebone formation in the class Cephalopoda. In this study, the structure and secretion function of cuttlebone sac of the golden cuttlefish Sepia esculenta was analyzed using the histological and histochemical methods. The results showed that high and columnar cells located in sac epithelium, and flat cells existed near the base membrane. A lot of fibroblasts were found in the lateral mantle collective tissue. Some mucus, mucopolysaccharide and alkaline phosphatase (ALP) were found in the sac. The ultrastructural characteristics of Quasi-connective-tissue-calcium cells (QCTCC) were observed using a transmission electron microscope (TEM). The relationship between cuttlebone sac secretion function and shell formation was discussed.

  17. Primary yolk sac tumor of seminal vesicle: a case report and literature review

    Directory of Open Access Journals (Sweden)

    Yao Xu-Dong

    2012-09-01

    Full Text Available Abstract Background Yolk sac tumor (endodermal sinus tumor is a rare malignant germ cell tumor arising in the testis or ovary. Extragonadal yolk sac tumor is even rarer and has only been described in case reports. Due to the rarity of the tumors, the appropriately optimal treatment remains unclear. We report a case of yolk sac tumor in the seminal vesicle. Case A 38-year-old Asian male presented with gross hematuria and hemospermia. Transrectal ultrasound scan showed a solid mass in the left seminal vesicle and the scrotal sonography showed no abnormalities. Bilateral seminal vesicles were resected, and histopathological examination showed a typical pattern of yolk sac tumor (YST. The patient responded poorly to comprehensive treatment of radiotherapy, chemotherapy and surgeries, developed systemic multiple metastases, and died of cachexia one and half years after diagnosis.

  18. Experience of direct percutaneous sac injection in type II endoleak using cone beam computed tomography.

    Science.gov (United States)

    Park, Yoong-Seok; Do, Young Soo; Park, Hong Suk; Park, Kwang Bo; Kim, Dong-Ik

    2015-04-01

    Cone beam CT, usually used in dental area, could easily obtain 3-dimensional images using cone beam shaped ionized radiation. Cone beam CT is very useful for direct percutaneous sac injection (DPSI) which needs very precise measurement to avoid puncture of inferior vena cava or vessel around sac or stent graft. Here we describe two cases of DPSI using cone beam CT. In case 1, a 79-year-old male had widening of preexisted type II endoleak after endovascular aneurysm repair (EVAR). However, transarterial embolization failed due to tortuous collateral branches of lumbar arteries. In case 2, a 72-year-old female had symptomatic sac enlargement by type II endoleak after EVAR. However, there was no route to approach the lumbar arteries. Therefore, we performed DPSI assisted by cone beam CT in cases 1, 2. Six-month CT follow-up revealed no sign of sac enlargement by type II endoleak.

  19. Discussion and improvement of the refined COSMO-SAC parameters for solubility predictions: part 2

    OpenAIRE

    Bouillot, Baptiste; Teychené, Sébastien; Biscans, Béatrice

    2013-01-01

    Solubility of drugs is a key piece of information for the pharmaceutical industry. Despite its importance, particularly at the beginning of a new drug process development, this thermodynamic property of the solid-liquid equilibria (SLE) can hardly be predicted for a given molecule in a given solvent. In our recent works, some thermodynamic models (UNIFAC and its modifications, COSMO-SAC and its refinements, NRTL-SAC) were investigated and compared for solubility prediction. The main drawbacks...

  20. Sac1--Vps74 structure reveals a mechanism to terminate phosphoinositide signaling in the Golgi apparatus

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Yiying; Deng, Yongqiang; Horenkamp, Florian; Reinisch, Karin M.; Burd, Christopher G. [Yale-MED

    2014-08-25

    Sac1 is a phosphoinositide phosphatase of the endoplasmic reticulum and Golgi apparatus that controls organelle membrane composition principally via regulation of phosphatidylinositol 4-phosphate signaling. We present a characterization of the structure of the N-terminal portion of yeast Sac1, containing the conserved Sac1 homology domain, in complex with Vps74, a phosphatidylinositol 4-kinase effector and the orthologue of human GOLPH3. The interface involves the N-terminal subdomain of the Sac1 homology domain, within which mutations in the related Sac3/Fig4 phosphatase have been linked to Charcot–Marie–Tooth disorder CMT4J and amyotrophic lateral sclerosis. Disruption of the Sac1–Vps74 interface results in a broader distribution of phosphatidylinositol 4-phosphate within the Golgi apparatus and failure to maintain residence of a medial Golgi mannosyltransferase. The analysis prompts a revision of the membrane-docking mechanism for GOLPH3 family proteins and reveals how an effector of phosphoinositide signaling serves a dual function in signal termination.

  1. Sac1-Vps74 structure reveals a mechanism to terminate phosphoinositide signaling in the Golgi apparatus.

    Science.gov (United States)

    Cai, Yiying; Deng, Yongqiang; Horenkamp, Florian; Reinisch, Karin M; Burd, Christopher G

    2014-08-18

    Sac1 is a phosphoinositide phosphatase of the endoplasmic reticulum and Golgi apparatus that controls organelle membrane composition principally via regulation of phosphatidylinositol 4-phosphate signaling. We present a characterization of the structure of the N-terminal portion of yeast Sac1, containing the conserved Sac1 homology domain, in complex with Vps74, a phosphatidylinositol 4-kinase effector and the orthologue of human GOLPH3. The interface involves the N-terminal subdomain of the Sac1 homology domain, within which mutations in the related Sac3/Fig4 phosphatase have been linked to Charcot-Marie-Tooth disorder CMT4J and amyotrophic lateral sclerosis. Disruption of the Sac1-Vps74 interface results in a broader distribution of phosphatidylinositol 4-phosphate within the Golgi apparatus and failure to maintain residence of a medial Golgi mannosyltransferase. The analysis prompts a revision of the membrane-docking mechanism for GOLPH3 family proteins and reveals how an effector of phosphoinositide signaling serves a dual function in signal termination.

  2. Performance Evaluation of Photovoltaic Solar Air Conditioning

    Directory of Open Access Journals (Sweden)

    Snegirjovs A.

    2016-12-01

    Full Text Available Information on the electrical-driven solar air conditioning (SAC is rather scanty. A considerable body of technical data mostly concerns large-scale photo-voltaic solar air conditioning (PV-SAC systems. Reliable information about the energy output has arisen only in recent years; however, it is still not easily accessible, and sometimes its sources are closed. Despite these facts, solar energy researchers, observers and designers devote special attention to this type of SAC systems. In this study, performance evaluation is performed for the PV-SAC technology, in which low-power (up to 15 kWp of cooling power on average systems are used. Such a system contains a PV electric-driven compression chiller with cold and heat sensible thermal storage capacities, and a rejected energy unit used for preheating domestic hot water (DHW. In a non-cooling season, it is possible to partly employ the system in the reverse mode for DHW production. In this mode, the ambient air serves as a heat source. Besides, free cooling is integrated in the PV-SAC concept.

  3. Performance Evaluation of Photovoltaic Solar Air Conditioning

    Science.gov (United States)

    Snegirjovs, A.; Shipkovs, P.; Lebedeva, K.; Kashkarova, G.; Migla, L.; Gantenbein, P.; Omlin, L.

    2016-12-01

    Information on the electrical-driven solar air conditioning (SAC) is rather scanty. A considerable body of technical data mostly concerns large-scale photo-voltaic solar air conditioning (PV-SAC) systems. Reliable information about the energy output has arisen only in recent years; however, it is still not easily accessible, and sometimes its sources are closed. Despite these facts, solar energy researchers, observers and designers devote special attention to this type of SAC systems. In this study, performance evaluation is performed for the PV-SAC technology, in which low-power (up to 15 kWp of cooling power on average) systems are used. Such a system contains a PV electric-driven compression chiller with cold and heat sensible thermal storage capacities, and a rejected energy unit used for preheating domestic hot water (DHW). In a non-cooling season, it is possible to partly employ the system in the reverse mode for DHW production. In this mode, the ambient air serves as a heat source. Besides, free cooling is integrated in the PV-SAC concept.

  4. Discovering Focus: Helping Students with ADD (Attention Deficit Disorder)

    Science.gov (United States)

    Valkenburg, Jim

    2012-01-01

    Attention Deficit Disorder (ADD) is a neurological disorder which effects learning and that has a confusing set of diagnostic symptoms and an even more confusing set of remedies ranging from medication to meditation to nothing at all. Current neurological research suggests, however, that there are strategies that the individual with ADD can use to…

  5. Reliability of the Assessment of Dual Diagnosis (ADD).

    Science.gov (United States)

    Matson, Johnny L.; Bamburg, Jay W.

    1998-01-01

    The initial psychometric properties of the Assessment for Dual Diagnosis (ADD), a new scale designed to screen for psychopathology in individuals with mild and moderate mental retardation, was examined. The ADD was found to have high stability across raters, high stability over time, and good internal consistency. (Author/DB)

  6. Solar assisted heat pump on air collectors: A simulation tool

    Energy Technology Data Exchange (ETDEWEB)

    Karagiorgas, Michalis; Galatis, Kostas; Tsagouri, Manolis [Department of Mechanical Engineering Educators, ASPETE, N. Iraklio, GR 14121 (Greece); Tsoutsos, Theocharis [Environmental Engineering Dept., Technical University of Crete, Technical University Campus, GR 73100, Chania (Greece); Botzios-Valaskakis, Aristotelis [Centre for Renewable Energy Sources (CRES), 19th km Marathon Ave., GR 19001, Pikermi (Greece)

    2010-01-15

    The heating system of the bioclimatic building of the Greek National Centre for Renewable Energy Sources (CRES) comprises two heating plants: the first one includes an air source heat pump, Solar Air Collectors (SACs) and a heat distribution system (comprising a fan coil unit network); the second one is, mainly, a geothermal heat pump unit to cover the ground floor thermal needs. The SAC configuration as well as the fraction of the building heating load covered by the heating plant are assessed in two operation modes; the direct (hot air from the collectors is supplied directly to the heated space) and the indirect mode (warm air from the SAC or its mixture with ambient air is not supplied directly to the heated space but indirectly into the evaporator of the air source heat pump). The technique of the indirect mode of heating aims at maximizing the efficiency of the SAC, saving electrical power consumed by the compressor of the heat pump, and therefore, at optimizing the coefficient of performance (COP) of the heat pump due to the increased intake of ambient thermal energy by means of the SAC. Results are given for three research objectives: assessment of the heat pump efficiency whether in direct or indirect heating mode; Assessment of the overall heating plant efficiency on a daily or hourly basis; Assessment of the credibility of the suggested simulation model TSAGAIR by comparing its results with the TRNSYS ones. (author)

  7. Established and potential physiological roles of bicarbonate-sensing soluble adenylyl cyclase (sAC) in aquatic animals.

    Science.gov (United States)

    Tresguerres, Martin; Barott, Katie L; Barron, Megan E; Roa, Jinae N

    2014-03-01

    Soluble adenylyl cyclase (sAC) is a recently recognized source of the signaling molecule cyclic AMP (cAMP) that is genetically and biochemically distinct from the classic G-protein-regulated transmembrane adenylyl cyclases (tmACs). Mammalian sAC is distributed throughout the cytoplasm and it may be present in the nucleus and inside mitochondria. sAC activity is directly stimulated by HCO3(-), and sAC has been confirmed to be a HCO3(-) sensor in a variety of mammalian cell types. In addition, sAC can functionally associate with carbonic anhydrases to act as a de facto sensor of pH and CO2. The two catalytic domains of sAC are related to HCO3(-)-regulated adenylyl cyclases from cyanobacteria, suggesting the cAMP pathway is an evolutionarily conserved mechanism for sensing CO2 levels and/or acid/base conditions. Reports of sAC in aquatic animals are still limited but are rapidly accumulating. In shark gills, sAC senses blood alkalosis and triggers compensatory H(+) absorption. In the intestine of bony fishes, sAC modulates NaCl and water absorption. And in sea urchin sperm, sAC may participate in the initiation of flagellar movement and in the acrosome reaction. Bioinformatics and RT-PCR results reveal that sAC orthologs are present in most animal phyla. This review summarizes the current knowledge on the physiological roles of sAC in aquatic animals and suggests additional functions in which sAC may be involved.

  8. SAC-Ⅲ短臂离心机的研制与应用研究%Development and Application of SAC-Ⅲ Human Short-arm Centrifuge

    Institute of Scientific and Technical Information of China (English)

    张毅; 杨长斌; 高原; 张舒; 刘新宇; 王永春; 孙喜庆

    2012-01-01

    Objective To develop a new type of human short-arm centrifuge( SAC-Ⅲ ) and observe its application. Methods SAC-Ⅲ consisted of electric power system, operating and controlling system, audio and video monitoring system, tread wheel resistance training and work measuring system, electric brake system, short arm and supporting construction, etc. Driven by electric power, the short arm moved around the axis and artificial gravity was produced. Sixteen healthy male subjects were exposed to artificial gravity induced by SAC-Ⅲ and heart rate ( HR) , respiratory rate ( RR) were monitored with a wireless physiological signal recording device. Results As compared with those of baseline, Both HR and RR increased when subjects were exposed to 1 G, increased significantly when exposed to 2 G (P<0.05), and further increased when exposed to 3 G (P <0. 01). Conclusion The changes of HR and RR when exposed to artificial gravity shows that SAC-Ⅲhuman centrifuge combined exercise can be used for anti-G physiological training or as a promising countermeasure a-gainst the influcence of microgravity.%目的 研制一种新型短臂离心机(SAC-Ⅲ)并观察其应用效果.方法 SAC-Ⅲ型短臂离心机由电源、操作控制系统、声像监控系统、脚踏阻力锻炼及做功计量系统、电控静音刹车系统、工作转臂及支承结构等部件组成.通过电源系统,使工作转臂绕支撑装置作圆周运动,产生人工重力.选取16名男性志愿者,在SAC-Ⅲ型短臂离心机上人工重力暴露,分析在1G,2G和3G作用下心率和呼吸等生理参数的变化.结果 利用SAC-Ⅲ型短臂离心机,与基础值相比,心率和呼吸率1G暴露时呈增加趋势,2G暴露时显著增加(P<0.05),3G暴露时进一步增加(P<0.01).结论 在SAC-Ⅲ型短臂离心机暴露时,心率和呼吸率的变化表明其能有效模拟人工重力作用,可作为飞行人员抗荷生理训练设备或航天员对抗失重生理影响的有力措施.

  9. The SAC Mentality: The Origins of Strategic Air Command’s Organizational Culture, 1948-51

    Science.gov (United States)

    2015-04-01

    failed to drop the number of allotted bombs; they practiced in unrealistic conditions; and visual bombing received em- phasis during training. Visual ...As LeMay emphasized in his manuals, “The importance of teamwork cannot be overemphasized. The individuals who are proficient in their respective...Gen Paul Carlton remembered when LeMay selected him as his aide -de-camp. LeMay wanted a highly experienced pilot to run his crew. Carlton recalled

  10. In Vivo and Cadaver Studies of the Canalicular/Lacrimal Sac Mucosal Folds

    Directory of Open Access Journals (Sweden)

    Yongsheng You

    2016-01-01

    Full Text Available Purpose. The study aimed to investigate canalicular/lacrimal sac mucosal folds (CLS-MFs in vivo and in cadavers in order to explore their functional roles in the lacrimal drainage system. Method. The observations of CLS-MFs in vivo were performed on 16 patients with chronic dacryocystitis after undergoing an endonasal endoscopic dacryocystorhinostomy (EE-DCR. The lacrimal sacs and common canaliculi of 19 adult cadavers were dissected. The opening/closing of an orifice and mucosal fold was recorded. All of the specimens were subjected to a histological examination. Results. The upper and lower lacrimal canaliculi in all of the samples united to form a common canaliculus that opened to the lacrimal sac. CLS-MFs were observed in 10 of the 16 patients (62.5% and 9 of the 19 cadavers (47.4%. The orifices or mucosal folds could be opened or closed when related muscles contracted or relaxed. Histological sections showed a mucosal fold at one side of an orifice. Conclusion. Common canaliculus is the most common type that the canaliculus opens to lacrimal sac. CLS-MFs exist in a certain ratio that can be opened/closed with the movement of the orifices. They may be involved in the drainage of tears or the pathogenesis of acute dacryocystitis or lacrimal sac mucocele.

  11. Failure of zinc to prevent dysmorphogenesis of cultured rat conceptuses by anti-yolk sac antiserum

    Energy Technology Data Exchange (ETDEWEB)

    Marlow, R.; Freeman, S.J.

    1989-01-01

    Day 10 rat conceptuses were cultured for 48h in the presence of either cadmium or anti-vesceral yolk sac antiserum (AVYS). Cadmium was embryotoxic at concentrations exceeding 0.25 ug/ml while AVYS caused embryonic dysmorphogenesis, particularly affecting the optic vesicles, at concentrations of 2 ul/ml and above. The effect of pretreatment with zinc on embryotoxicity caused by cadmium or AVYS was studied. Zinc ameliorated the effects of cadmium but had no effect on AVYS-induced embryonic abnormalities. In a second set of experiments inhibition of /sup 125/I-labelled PVP uptake by the yolk sac of cultured whole conceptuses was studied. Cadmium and AVYS both inhibited uptake compared to control cultures. Zinc again ameliorated the effect of cadmium but had no action against AVYS-induced inhibition. These results are in contrast to their previous findings using isolated cultured yolk sacs in which zinc ameliorated the inhibitory effects on /sup 125/I-labelled PVP uptake of both cadmium and AVYS. These data show that in experiments using the isolated cultured yolk sac and the intact cultured conceptus, a qualitatively different response in yolk sac behavior is observed under similar experimental conditions.

  12. Sac-0601 prevents retinal vascular leakage in a mouse model of diabetic retinopathy.

    Science.gov (United States)

    Maharjan, Sony; Lee, Sujin; Agrawal, Vijayendra; Choi, Hyun-Jung; Maeng, Yong-Sun; Kim, Kyeojin; Kim, Nam-Jung; Suh, Young-Ger; Kwon, Young-Guen

    2011-04-25

    Endothelium integrity is important for the normal functioning of vessels, the disruption of which can lead to disease. The blood-retinal barrier required for normal retinal function is compromised in diabetic retinopathy, causing retinal vascular leakage. Previously, we demonstrated the ability of Sac-0601[((2R,3S)-3-acetoxy-6-((3S,10R,13R,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy)-3,6-dihydro-2H-pyran-2-yl)methyl acetate], a pseudo-sugar derivative of cholesterol, to increase survival of retinal endothelial cells. In the present study, we evaluated the ability of Sac-0601 to prevent retinal vascular leakages in vitro and in vivo. Sac-0601 treatment blocked VEGF-induced formation of actin stress fibers and stabilized the cortical actin ring in retinal endothelial cells. It also inhibited degradation of occludin, an important tight junction protein, and blocked VEGF-induced disruption of its linear pattern at the cell border. The [(14)C] sucrose permeability assay demonstrated that Sac-0601 was able to prevent VEGF-induced retinal endothelial permeability. The compound inhibited the vascular leakage in retina of mice intravitreally injected with VEGF. And it also significantly reduced the leakage in retina of diabetic retinopathy mice model. Taken together, our findings suggest the potential therapeutic usefulness of Sac-0601 for retinal vascular permeability diseases.

  13. Prox1 expression in the endolymphatic sac revealed by whole-mount fluorescent imaging of Prox1-GFP transgenic mice.

    Science.gov (United States)

    Miyashita, Takenori; Burford, James L; Hong, Young-Kwon; Gevorgyan, Haykanush; Lam, Lisa; Hoshikawa, Hiroshi; Mori, Nozomu; Peti-Peterdi, Janos

    2015-01-30

    This study describes a technical breakthrough in endolymphatic sac research, made possible by the use of the recently generated Prox1-GFP transgenic mouse model. Whole-mount imaging techniques through the decalcified temporal bone and three-dimensional observations of Prox1-GFP mouse tissue revealed the positive labeling of the endolymphatic sac in adult stage, and allowed, for the first time, the GFP-based identification of endolymphatic sac epithelial cells. Prox1 expression was observed in all parts of the endolymphatic sac epithelia. In intermediate portion of the endolymphatic sac, mitochondria-rich cells did not express Prox1, although ribosome-rich cells showed strong GFP labeling. The anatomical relationship between the endolymphatic sac and the surrounding vasculature was directly observed. In the endolymphatic sac, expression of Prox1 may suggest progenitor cell-like pluripotency or developmental similarity to systemic lymphatic vessels in other organs. This whole-mount imaging technique of the endolymphatic sac can be combined with other conventional histological, sectioning, and labeling techniques and will be very useful for future endolymphatic sac research.

  14. An atypical case of lacrimal sac fistula located on the temporal side of the lateral canthus.

    Science.gov (United States)

    Kim, Gyu-Nam; Huh, Hyun-Do; Park, Jong-Moon; Seo, Seong-Wook

    2012-12-01

    We report a case of congenital lacrimal sac fistula located on the temporal side of the lateral canthus. A systemically healthy 1-year-old girl came to the outpatient clinic with a complaint of tearing on the temporal side of the right lateral canthus since birth. On examination, a small orifice was found in the skin on the temporal side of the lateral canthus. There was no evidence of inflammation or swelling within the opening. Surgeons carried out an operation under general anesthesia. They passed a probe through the lacrimal orifice and advanced it toward the lacrimal sac. Next, they introduced saline to the inferior punctum and found that it drained to the lateral fistula. The lower lid stretched as the dissected fistula was pulled. After the operation, the patient was free of the symptom. This paper is to report a case of congenital lacrimal sac fistula located on the temporal side of the lateral canthus.

  15. Scanning electron microscopy of the human endolymphatic sac: a preliminary report.

    Science.gov (United States)

    Galey, F R; House, W F

    1980-04-01

    Scanning electron microscopy has been used to examine and compare one normal endolymphatic sac with one endolymphatic sac from a patient with Meniere's disease. The surgical procedure for obtaining these specimens and their preparation for scanning electron microscopy are described. The luminal surface of the rugose portion of both specimens was lined with two populations of epithelial cells: one with a dome-shaped apical surface, the other with a flattened polygonal surface. The surface of dome-shaped cells in both specimens was covered with microvilli. Neither specimen had observable loss of epithelial integrity or fibrosis.

  16. Endolymphatic Sac Tumor Showing Increased Activity on 68Ga DOTATATE PET/CT.

    Science.gov (United States)

    Papadakis, Georgios Z; Millo, Corina; Sadowski, Samira M; Bagci, Ulas; Patronas, Nicholas J

    2016-10-01

    Endolymphatic sac tumors (ELSTs) are rare tumors arising from the epithelium of the endolymphatic sac and duct that can be either sporadic or associated with von Hippel-Lindau (VHL) disease. We report a case of a VHL patient with histologically proven residual ELST who underwent Ga DOTATATE PET/CT showing increased activity (SUVmax, 6.29) by the ELST. The presented case of a VHL-associated ELST with increased Ga DOTATATE uptake indicates cell-surface expression of somatostatin receptors by this tumor, suggesting the potential application of somatostatin receptor imaging using Ga DOTA-conjugated peptides in the workup and management of these patients.

  17. Documented bites by a yellow sac spider (Cheiracanthium punctorium in Italy: a case report

    Directory of Open Access Journals (Sweden)

    R Papini

    2012-01-01

    Full Text Available In Italy reports of human envenomations by yellow sac spiders have been sporadic. Since increasing clinical information would improve understanding of the danger of yellow sac spiders to humans, we report the case of a 7-year-old child and her father bitten by a documented Cheiracanthium punctorium. They developed acute persistent pain with local skin signs and numbness, and required emergency treatment. The father recovered completely within 1 to 2 hours and the child within 3 to 4 days after treatment, probably as a result of spontaneous evolution. Clinicians should be aware of the risks and immediate management of spider bites.

  18. Effects of Technological Parameters on the Mechanical Performances of SAC-cementitious Materials

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    A new type of SAC-cementitious material was manufactured by taking sulphoaluminate cement(SAC) as the basic material, polyvinyl alcohol(PVA) as the organic polymer and adding coupling agent(KH). Its flexural strength can reach 165 MPa, the compressive strength can be larger than 267 MPa.A set of fitable technological parameters of the material were gained through experiments. In addition, the flexural strength and toughness can be improved greatly by adding KH, whose values can be increased by 49.76% and 14.55%, respectively.

  19. The actin-related protein Sac1 is required for morphogenesis and cell wall integrity in Candida albicans.

    Science.gov (United States)

    Zhang, Bing; Yu, Qilin; Jia, Chang; Wang, Yuzhou; Xiao, Chenpeng; Dong, Yijie; Xu, Ning; Wang, Lei; Li, Mingchun

    2015-08-01

    Candida albicans is a common pathogenic fungus and has aroused widespread attention recently. Actin cytoskeleton, an important player in polarized growth, protein secretion and organization of cell shape, displays irreplaceable role in hyphal development and cell integrity. In this study, we demonstrated a homologue of Saccharomyces cerevisiae Sac1, in C. albicans. It is a potential PIP phosphatase with Sac domain which is related to actin organization, hyphal development, biofilm formation and cell wall integrity. Deletion of SAC1 did not lead to insitiol-auxotroph phenotype in C. albicans, but this gene rescued the growth defect of S. cerevisiae sac1Δ in the insitiol-free medium. Hyphal induction further revealed the deficiency of sac1Δ/Δ in hyphal development and biofilm formation. Fluorescence observation and real time PCR (RT-PCR) analysis suggested both actin and the hyphal cell wall protein Hwp1 were overexpressed and mislocated in this mutant. Furthermore, cell wall integrity (CWI) was largely affected by deletion of SAC1, due to the hypersensitivity to cell wall stress, changed content and distribution of chitin in the mutant. As a result, the virulence of sac1Δ/Δ was seriously attenuated. Taken together, this study provides evidence that Sac1, as a potential PIP phosphatase, is essential for actin organization, hyphal development, CWI and pathogenicity in C. albicans.

  20. National Technical Committee on Household Appliances of Standardization Administration of China (SAC/TC 46) Upon the approval of Standardization

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Administration of China (SAC),National Technical Committee on Household Appliances of Standardization Administration of China (SAC/TC 46) was officially established in May 2005,taking charge of the work of standardization regarding the safety,performance,installation and repair,etc.,of household and similar electrical appliances nationwide.The secretariat was established in China Household Electric Appliance Research Institute.

  1. Compiling the functional data-parallel language SaC for Microgrids of Self-Adaptive Virtual Processors

    NARCIS (Netherlands)

    Grelck, C.; Herhut, S.; Jesshope, C.; Joslin, C.; Lankamp, M.; Scholz, S.-B.; Shafarenko, A.

    2009-01-01

    We present preliminary results from compiling the high-level, functional and data-parallel programming language SaC into a novel multi-core design: Microgrids of Self-Adaptive Virtual Processors (SVPs). The side-effect free nature of SaC in conjunction with its data-parallel foundation make it an id

  2. Yolk sac tumor of the seminal vesicles: A rare malignant cause of hematospermia

    Directory of Open Access Journals (Sweden)

    Jonathan D Gill

    2015-01-01

    Full Text Available Extra-gonadal yolk sac tumors (YSTs are rare and generally associated with poor outcomes. Involvement of the seminal vesicles is extremely rare with only one previously described case. We report a case of a primary YST of the seminal vesicles and discuss the management strategy.

  3. Yolk sac tumor of the seminal vesicles: A rare malignant cause of hematospermia.

    Science.gov (United States)

    Gill, Jonathan D; Bhattarai, Selina; Patel, Chirag N; Paul, Alan B

    2015-01-01

    Extra-gonadal yolk sac tumors (YSTs) are rare and generally associated with poor outcomes. Involvement of the seminal vesicles is extremely rare with only one previously described case. We report a case of a primary YST of the seminal vesicles and discuss the management strategy.

  4. Oxygenated fixation demonstrates novel and improved ultrastructural features of the human endolymphatic sac

    DEFF Research Database (Denmark)

    Møller, Martin Nue; Caye-Thomasen, Per; Qvortrup, Klaus

    2013-01-01

    in the intraosseous part of the sac: mitochondria-rich cells, ribosome-rich cells, and nonclassifiable cells. A fourth cell type was found in the extraosseous part. Novel ultrastructural features of the epithelial lining and the subepithelial layer are described and discussed. CONCLUSIONS: The results in the present...

  5. Laminin from rat yolk sac tumor: isolation, partial characterization, and comparison with mouse laminin

    DEFF Research Database (Denmark)

    Engvall, E; Krusius, T; Wewer, U

    1983-01-01

    Laminin was isolated from a rat yolk sac tumor by salt extraction, gel filtration, and affinity chromatography on heparin-Sepharose. The purified laminin gave two polypeptide chains with approximate Mr of 200,000 and 400,000 in sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Its amino...

  6. Bleomycin-Induced Flagellate Erythema in a Patient Diagnosed with Ovarian Yolk Sac Tumor

    Directory of Open Access Journals (Sweden)

    Stergios Boussios

    2015-01-01

    Full Text Available Flagellate linear hyperpigmentation can rarely be caused by the chemotherapy agent, bleomycin. Herein, we describe the case of a 20-year-old woman treated with bleomycin for an ovarian yolk sac tumor and review the prominent features of this form of dermatitis.

  7. Appendiceal pus in a hernia sac simulating strangulated femoral hernia: a case report.

    Science.gov (United States)

    Hsiao, Tien-Fa; Chou, Yenn-Hwei

    2011-03-23

    Acute appendicitis involving the hernia sac is infrequent but well-documented in medical literature. In most instances, it occurs within the right inguinal (Amyand's hernia) or right femoral hernia (de Garengeot hernia). The diagnosis is always mistaken for incarcerated groin hernia. During surgery, the appendix itself, either perforated or strangulated, is most commonly encountered within the hernia sac. In very rare occasions, only appendiceal pus is found in the hernia sac. In this paper, we report the case of a 90-year-old woman with acute appendicitis and a tender mass in the right groin. Typical findings of acute appendicitis by computed tomography (CT) and incarcerated femoral hernia with groin cellulitis misled us into preoperative diagnosis of strangulated femoral hernia. Acute phlegmonous inflammation of the incarcerated femoral hernia sac containing pus only and acute suppurative appendicitis were found intraoperatively. This case presents a rare complication of acute appendicitis and the first report of CT-documented appendiceal pus-contained femoral hernia. Knowledge of this rare condition is helpful in establishing preoperative diagnosis and patient management decisions.

  8. Differential gene expression profiles in the venom gland/sac of Orancistrocerus drewseni (Hymenoptera: Eumenidae).

    Science.gov (United States)

    Baek, Ji Hyeong; Woo, Tae Ha; Kim, Chang Bae; Park, Jong Hwa; Kim, Hyojoong; Lee, Seunghwan; Lee, Si Hyeock

    2009-08-01

    To determine differential gene expression profiles in the venom gland and sac (gland/sac) of a solitary hunting wasp species, Orancistrocerus drewseni Saussure (1857), a subtractive cDNA library was constructed by suppression subtractive hybridization. A total of 498 expressed sequence tags (EST) were clustered and assembled into 205 contigs (94 multiple sequences and 111 singletons). About 65% (134) of the contigs had matched BLASTx hits (E< or =10(-4)). Among these, 115 contigs had similarity to proteins with assigned molecular function in the Gene Ontology database, and most of them (112 contigs, 83%) were homologous to genes from Hymenoptera, particularly to Apis mellifera (98 contigs). The contigs encoding hyaluronidase and phospholipase A2, known to be main components of wasp venoms, were found in high frequencies (27 and 4%, respectively, as judged by the number of ESTs) in the gene ontology category of catalytic activity. Full-length open reading frames of hyaluronidase and phospholipase A2 were characterized and their abundance in the venom gland/sac was confirmed by quantitative real-time PCR. Several contigs encoding enzymes, including zinc-metallopeptidases that are likely involved in the processing and activation of venomous proteins or peptides, were also identified from the library. Discovery of venom gland/sac-specific genes should promote further studies on biologically active components in the venom of O. drewseni.

  9. Dispensability of the SAC Depends on the Time Window Required by Aurora B to Ensure Chromosome Biorientation

    Science.gov (United States)

    Monje-Casas, Fernando

    2015-01-01

    Aurora B and the spindle assembly checkpoint (SAC) collaborate to ensure the proper biorientation of chromosomes during mitosis. However, lack of Aurora B activity and inactivation of the SAC have a very different impact on chromosome segregation. This is most evident in Saccharomyces cerevisiae, since in this organism the lack of Aurora B is lethal and leads to severe aneuploidy problems, while the SAC is dispensable under normal growth conditions and mutants in this checkpoint do not show evident chromosome segregation defects. We demonstrate that the efficient repair of incorrect chromosome attachments by Aurora B during the initial stages of spindle assembly in budding yeast determines the lack of chromosome segregation defects in SAC mutants, and propose that the differential time window that Aurora B kinase requires to establish chromosome biorientation is the key factor that determines why some cells are more dependent on a functional SAC than others. PMID:26661752

  10. The corn snake yolk sac becomes a solid tissue filled with blood vessels and yolk-rich endodermal cells

    Science.gov (United States)

    Elinson, Richard P.; Stewart, James R.

    2014-01-01

    The amniote egg was a key innovation in vertebrate evolution because it supports an independent existence in terrestrial environments. The egg is provisioned with yolk, and development depends on the yolk sac for the mobilization of nutrients. We have examined the yolk sac of the corn snake Pantherophis guttatus by the dissection of living eggs. In contrast to the familiar fluid-filled sac of birds, the corn snake yolk sac invades the yolk mass to become a solid tissue. There is extensive proliferation of yolk-filled endodermal cells, which associate with a meshwork of blood vessels. These novel attributes of the yolk sac of corn snakes compared with birds suggest new pathways for the evolution of the amniote egg. PMID:24402715

  11. Characterization of Sac10a, a hyperthermophile DNA-binding protein from Sulfolobus acidocaldarius.

    Science.gov (United States)

    Edmondson, Stephen P; Kahsai, Mebrahtu A; Gupta, Ramesh; Shriver, John W

    2004-10-19

    Sac10a is a member of a group of basic DNA-binding proteins thought to be important in chromatin structure and regulation in the archaeon Sulfolobus. We describe here the isolation, gene identification, and biophysical characterization of native Sac10a. The protein exists as a 23.8 kDa homodimer at pH 7 and unfolds with a T degrees of 122 degrees C. Dissociation of the dimer into folded globular subunits is promoted by decreased pH and salt concentration. Thermal unfolding of the monomeric subunits occurred with two transitions, indicating two independent domains. The dimer demonstrated a high affinity for duplex poly(dAdT) with a K(D) of 5 x 10(-)(10) M and a site size of 17 bp (in 0.15 M KCl, pH 7), with only weak binding (K(D) > 5 x 10(-)(6) M) to poly(dA)-poly(dT), poly(dGdC), poly(dG)-poly(dC), and Escherichia coli DNA under similar conditions. Binding to poly(dAdT) resulted in distortions in the DNA duplex that were consistent with overwinding as indicated by inversion of the CD spectrum of the DNA. The monomeric subunits are predicted to adopt a winged helix DNA-binding motif which dimerizes through formation of a two-stranded coiled coil involving an extended C-terminal helix with more than four heptad repeats (about 45 A in length). This is the first example of the conserved archaeal transcription regulator domain COG3432 to be characterized. Sequences for homologous proteins containing both COG3432 and predicted coiled coil domains occur in the genomes of both crenarchaeota (Sulfolobus, Pyrobaculum, Aeropyrum) and euryarchaeota (Methanosarcina, Methanococcus, Archaeoglobus, Thermoplasma), with multiple genes in some species. Sac10a shows no sequence similarity to the other Sulfolobus chromatin proteins Sac7d, Sac8, Sso10b2, and Alba.

  12. Entire lacrimal sac within the ethmoid sinus: outcomes of powered endoscopic dacryocystorhinostomy

    Directory of Open Access Journals (Sweden)

    Ali MJ

    2016-07-01

    Full Text Available Mohammad Javed Ali, Swati Singh, Milind N NaikInstitute of Dacryology, LV Prasad Eye Institute, Hyderabad, India Background: The aim of this study was to report the outcomes of powered endoscopic dacryocystorhinostomy (PEnDCR in patients with lacrimal sac within the sinus.Materials and methods: Retrospective analysis was performed on all patients who underwent PEnDCR and were intraoperatively documented to have complete lacrimal sac in sinus. Data collected included demographics, clinical presentations, associated lacrimal and nasal anomalies, intraoperative findings, intraoperative guidance, complications, postoperative ostium behavior, and anatomical and functional success. A minimum follow-up of 6 months postsurgery was considered for final analysis.Results: A total of 17 eyes of 15 patients underwent PEnDCR using standard protocols, but with additional intraoperative guidance where required and careful maneuvering in the ethmoid sinus. The mean age of the patients was 37.2 (range 17–60 years. Of the unilateral cases, 69% (nine of 13 showed left-side predisposition; 80% of patients showed regurgitation on pressure over the lacrimal sac area. Associated lacrimal and nasal anomalies were observed in 13.3% (two of 15 and 40% (six of 15, respectively. At a mean follow-up of 6.6 months, anatomical and functional success were observed in 93.3% (14 of 15. One patient showed failure secondary to cicatricial closure of the ostium.Conclusion: An entire sac within an ethmoid sinus poses a surgical challenge. Good sinus-surgery training, thorough knowledge of endoscopic anatomy, careful maneuvering, and use of intraoperative navigation guidance result in good outcomes with PEnDCR.Keywords: lacrimal sac, ethmoid sinus, endoscopic, DCR

  13. Crystal plasticity finite element analysis of deformation behaviour in SAC305 solder joint

    Science.gov (United States)

    Darbandi, Payam

    Due to the awareness of the potential health hazards associated with the toxicity of lead (Pb), actions have been taken to eliminate or reduce the use of Pb in consumer products. Among those, tin (Sn) solders have been used for the assembly of electronic systems. Anisotropy is of significant importance in all structural metals, but this characteristic is unusually strong in Sn, making Sn based solder joints one of the best examples of the influence of anisotropy. The effect of anisotropy arising from the crystal structure of tin and large grain microstructure on the microstructure and the evolution of constitutive responses of microscale SAC305 solder joints is investigated. Insights into the effects of key microstructural features and dominant plastic deformation mechanisms influencing the measured relative activity of slip systems in SAC305 are obtained from a combination of optical microscopy, orientation imaging microscopy (OIM), slip plane trace analysis and crystal plasticity finite element (CPFE) modeling. Package level SAC305 specimens were subjected to shear deformation in sequential steps and characterized using optical microscopy and OIM to identify the activity of slip systems. X-ray micro Laue diffraction and high energy monochromatic X-ray beam were employed to characterize the joint scale tensile samples to provide necessary information to be able to compare and validate the CPFE model. A CPFE model was developed that can account for relative ease of activating slip systems in SAC305 solder based upon the statistical estimation based on correlation between the critical resolved shear stress and the probability of activating various slip systems. The results from simulations show that the CPFE model developed using the statistical analysis of activity of slip system not only can satisfy the requirements associated with kinematic of plastic deformation in crystal coordinate systems (activity of slip systems) and global coordinate system (shape changes

  14. Electromigration effect on intermetallic growth and Young's modulus in SAC solder joint

    Science.gov (United States)

    Xu, Luhua; Pang, John H. L.; Ren, Fei; Tu, K. N.

    2006-12-01

    Solid-state intermetallic compound (IMC) growth behavior plays and important role in solder joint reliability of electronic packaging assemblies. The directional impact of electromigration (EM) on the growth of interfacial IMCs in Ni/SAC/Ni, Cu/SAC/Ni single BGA ball solder joint, and fine pitch ball-grid-array (FPBGA) at the anode and cathode sides is reported in this study. When the solder joint was subjected to a current density of 5,000 A/cm2 at 125°C or 150°C, IMC layer growth on the anode interface was faster than that on the cathode interface, and both were faster than isothermal aging due to the Joule heating effect. The EM affects the IMC growth rate, as well as the composition and mechanical properties. The Young’s modulus and hardness were measured by the nanoindentation continuous stiffness measurement (CSM) from planar IMC surfaces after EM exposure. Different values were observed at the anode and cathode. The energy-dispersive x-ray (EDX) line scan analysis was conducted at the interface from the cathode to anode to study the presence of species; Ni was found in the anode IMC at SAC/Cu in the Ni/SAC/Cu joint, but not detected when the current was reverse. Electron-probe microanalysis (EPMA) measurement on the Ni/SAC/Ni specimen also confirmed the polarized Ni and Cu distributions in cathode and anode IMCs, which were (Ni0.57Cu0.43)3Sn4 and (Cu0.73Ni0.27)6Sn5, respectively. Thus, the Young’s moduli of the IMC are 141 and 175 GPa, respectively.

  15. The Care Tradition: Beyond "Add Women and Stir."

    Science.gov (United States)

    Noddings, Nel

    2001-01-01

    Examines problems of curricular inclusion, emphasizing ways of including the interests and contributions of women in social studies curricula. After describing the inadequacy of the "add women and stir" approach to inclusion, the paper discusses the tradition of care long identified with female life, then explores ways to preserve and extend this…

  16. Enhancing Teaching using MATLAB Add-Ins for Excel

    Science.gov (United States)

    Hamilton, Paul V.

    2004-01-01

    In this paper I will illustrate how to extend the capabilities of Microsoft Excel spreadsheets with add-ins created by MATLAB. Excel provides a broad array of fundamental tools but often comes up short when more sophisticated scenarios are involved. To overcome this short-coming of Excel while retaining its ease of use, I will describe how…

  17. Cloning and Sequencing Analysis of the Giardia Canis Gene MM/Sac-C/1%犬贾第虫MM/Sac-C/1基因的克隆及序列分析

    Institute of Scientific and Technical Information of China (English)

    赵永军; 战洪波; 王亮; 康桂英

    2016-01-01

    利用PCR技术从犬贾第虫滋养中扩增出了2004bp大小的MM/Sac-C/1基因,构建了pMD-MM/Sac-C/1克隆载体,并进行了序列测定,利用计算机对该序列进行了核苷酸同源性比较。结果表明,与Gene-Bank登陆的蓝氏贾第虫WB株AF236019序列比较,其同源性为98%,蛋白质同源性比较结果显示,与蓝氏贾第虫WB株表面抗原的同源性为90%,获得了犬贾第虫MM/Sac-C/1基因。%The PCR method was used to amplify Gene MM/Sac-C/1 in Giardia canis. The cloning vector pMD-MM/Sac-C/1 was constructed and sequenced. The homology of Gene MM/Sac-C/1 and AF236019 in GeneBank was 98%in the nucleotide,and 90%to Giardia lamblia. It was demonstrated that Gene MM/Sac-C/1 was present in Giardia canis.

  18. A single bivalent efficiently inhibits cyclin B1 degradation and polar body extrusion in mouse oocytes indicating robust SAC during female meiosis I.

    Directory of Open Access Journals (Sweden)

    Steffen Hoffmann

    Full Text Available The Spindle Assembly Checkpoint (SAC inhibits anaphase until microtubule-to-kinetochore attachments are formed, thus securing correct chromosome separation and preventing aneuploidy. Whereas in mitosis even a single unattached chromosome keeps the SAC active, the high incidence of aneuploidy related to maternal meiotic errors raises a concern about the lower efficiency of SAC in oocytes. Recently it was suggested that in mouse oocytes, contrary to somatic cells, not a single chromosome but a critical mass of chromosomes triggers efficient SAC pointing to the necessity of evaluating the robustness of SAC in oocytes. Two types of errors in chromosome segregation upon meiosis I related to SAC were envisaged: (1 SAC escape, when kinetochores emit SAC-activating signal unable to stop anaphase I; and (2 SAC deceive, when kinetochores do not emit the signal. Using micromanipulations and live imaging of the first polar body extrusion, as well as the dynamics of cyclin B1 degradation, here we show that in mouse oocytes a single bivalent keeps the SAC active. This is the first direct evaluation of SAC efficiency in mouse oocytes, which provides strong evidence that the robustness of SAC in mammalian oocytes is comparable to other cell types. Our data do not contradict the hypothesis of the critical mass of chromosomes necessary for SAC activation, but suggest that the same rule may govern SAC activity also in other cell types. We postulate that the innate susceptibility of oocytes to errors in chromosome segregation during the first meiotic division may not be caused by lower efficiency of SAC itself, but could be linked to high critical chromosome mass necessary to keep SAC active in oocyte of large size.

  19. Combining anti-cancer drugs with artificial sweeteners: synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)2(NH3)2] and cis-[Pt(tsac)2(NH3)2].

    Science.gov (United States)

    Al-Jibori, Subhi A; Al-Jibori, Ghassan H; Al-Hayaly, Lamaan J; Wagner, Christoph; Schmidt, Harry; Timur, Suna; Baris Barlas, F; Subasi, Elif; Ghosh, Shishir; Hogarth, Graeme

    2014-12-01

    The new platinum(II) complexes cis-[Pt(sac)2(NH3)2] (sac=saccharinate) and cis-[Pt(tsac)2(NH3)2] (tsac=thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)2(NH3)2] x H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity.

  20. Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4 exhibits growth inhibitory effects in prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Shayan eSarkar

    2015-10-01

    Full Text Available The gene Par-4 (Prostate Apoptosis Response 4 was originally identified in prostate cancer cells undergoing apoptosis and its product Par-4 showed cancer specific pro-apoptotic activity. Particularly, the SAC domain of Par-4 (SAC-Par-4 selectively kills cancer cells leaving normal cells unaffected. The therapeutic significance of bioactive SAC-Par-4 is enormous in cancer biology; however, its large scale production is still a matter of concern. Here we report the production of SAC-Par-4-GFP fusion protein coupled to translational enhancer sequence (5′ AMV and apoplast signal peptide (aTP in transgenic Nicotiana tabacum cv. Samsun NN plants under the control of a unique recombinant promoter M24. Transgene integration was confirmed by genomic DNA PCR, Southern and Northern blotting, Real-time PCR and Nuclear run-on assays. Results of Western blot analysis and ELISA confirmed expression of recombinant SAC-Par-4-GFP protein and it was as high as 0.15% of total soluble protein. In addition, we found that targeting of plant recombinant SAC-Par-4-GFP to the apoplast and endoplasmic reticulum (ER was essential for the stability of plant recombinant protein in comparison to the bacterial derived SAC-Par-4. Deglycosylation analysis demonstrated that ER-targeted SAC-Par-4-GFP-SEKDEL undergoes O-linked glycosylation unlike apoplast-targeted SAC-Par-4-GFP. Furthermore, various in vitro studies like mammalian cells proliferation assay (MTT, apoptosis induction assays, and NF-κB suppression suggested the cytotoxic and apoptotic properties of plant-derived SAC-Par-4-GFP against multiple prostate cancer cell lines. Additionally, pre-treatment of MAT-LyLu prostate cancer cells with purified SAC-Par-4-GFP significantly delayed the onset of tumor in a syngeneic rat prostate cancer model. Taken altogether, we proclaim that plant made SAC-Par-4 may become a useful alternate therapy for effectively alleviating cancer in the new era.

  1. Induction of rat yolk sac carcinomas with consistent pattern of laminin, entactin, and type IV collagen biosynthesis

    DEFF Research Database (Denmark)

    Wewer, U

    1984-01-01

    Twenty-four yolk sac carcinomas in Lewis rats were experimentally induced by puncturing the pregnant uterine wall with a hypodermic needle at day 9-13 of gestation. Morphologically, the tumours were composed of parietal- and visceral yolk sac carcinoma and to a less degree of trophoblastic giant ...... to their biosynthesis of the basement membrane components laminin, entactin, and type IV collagen. This model system offers a simple approach to inducing rat yolk sac carcinomas for further morphological and biochemical characterization of the basement membrane....

  2. Multi-level security for computer networking - SAC digital network approach

    Science.gov (United States)

    Griess, W.; Poutre, D. L.

    The functional features and architecture of the SACDIN (SAC digital network) are detailed. SACDIN is the new data transmission segment for directing SAC's strategic forces. The system has 135 processor nodes at 32 locations and processes, distributes and stores data of any level of security classification. The sophistication of access nodes is dependent on the location. A reference monitor mediates the multilevel security by implementation of the multi-state machine concept, i.e., the Bell-LaPadula model (1973, 1974), which concludes that a secure state can never lead to an unsecure state. The monitor is controlled by the internal access control mechanism, which resides in PROM. Details of the access process are provided, including message flow on trusted paths appropriate to the security clearance of the user.

  3. A Rare Case of Endolymphatic Sac Tumour: Clinicopathologic Study and Surgical Management

    Directory of Open Access Journals (Sweden)

    Emanuele Ferri

    2014-01-01

    Full Text Available Objective. Endolymphatic sac tumor (ELST is a rare neoplasm arising from the intrapetrous portion of the endolymphatic sac, either isolated or in association with the von Hippel-Lindau disease. We report a sporadic case of ELST with an overview of the literature and a discussion of clinic-radiological, histopathologic, and surgical findings. Case Report. A young woman presented with a progressive hearing loss in the left ear. Otoscopy showed a reddish, bleeding hypotympanic mass. CT demonstrated an expansile lytic mastoid lesion extending to the middle ear, with bone erosion. MRI confirmed a lesion of increased signal on T1-weighted sequences. The patient underwent a canal wall-down tympanoplasty with complete removal of the tumor. Histopathology was consistent with a papillary ELST. Immunohistochemistry was positive for cytokeratin and chromogranin A. Conclusion. This paper highlights the rarity of ELST, the need for an accurate neuroradiological and immunohistochemical study at the early stages, and the timeliness of surgical treatment.

  4. Fungi infection in honeybee hives in regions affected by Brazilian sac brood

    Directory of Open Access Journals (Sweden)

    K.M. Keller

    2014-10-01

    Full Text Available The Brazilian Sac Brood is a disease that affects apiaries of Africanized bee hives in Brazil, thereby making them susceptible to high losses. This study investigated the pathogenicity of Africanized bee hives by the entomopathogenic fungi in a Brazilian Sac Brood endemic region. The degree of fungal contamination, presence of mycotoxins in beehive elements, and vulnerability of healthy beehives in environments subjected and not subjected to the disease were investigated. From the contaminating fungal load, species that are mycotoxin producers and pathogenic causing mortality in the bees have been isolated. The analysis of bee pollen and bee bread samples did not show the presence of the toxic pollen of Stryphnodendron (Fabaceae, which has been indicated as the causative agent of mortality in pre-pupal stage larvae. However, bee bread showed the highest correlation between substrate and fungal contamination.

  5. Intrinsic Levanase Activity of Bacillus subtilis 168 Levansucrase (SacB.

    Directory of Open Access Journals (Sweden)

    Luz Méndez-Lorenzo

    Full Text Available Levansucrase catalyzes the synthesis of fructose polymers through the transfer of fructosyl units from sucrose to a growing fructan chain. Levanase activity of Bacillus subtilis levansucrase has been described since the very first publications dealing with the mechanism of levan synthesis. However, there is a lack of qualitative and quantitative evidence regarding the importance of the intrinsic levan hydrolysis of B. subtilis levansucrase and its role in the levan synthesis process. Particularly, little attention has been paid to the long-term hydrolysis products, including its participation in the final levan molecules distribution. Here, we explored the hydrolytic and transferase activity of the B. subtilis levansucrase (SacB when levans produced by the same enzyme are used as substrate. We found that levan is hydrolyzed through a first order exo-type mechanism, which is limited to a conversion extent of around 30% when all polymer molecules reach a structure no longer suitable to SacB hydrolysis. To characterize the reaction, Isothermal Titration Calorimetry (ITC was employed and the evolution of the hydrolysis products profile followed by HPLC, GPC and HPAEC-PAD. The ITC measurements revealed a second step, taking place at the end of the reaction, most probably resulting from disproportionation of accumulated fructo-oligosaccharides. As levanase, levansucrase may use levan as substrate and, through a fructosyl-enzyme complex, behave as a hydrolytic enzyme or as a transferase, as demonstrated when glucose and fructose are added as acceptors. These reactions result in a wide variety of oligosaccharides that are also suitable acceptors for fructo-oligosaccharide synthesis. Moreover, we demonstrate that SacB in the presence of levan and glucose, through blastose and sucrose synthesis, results in the same fructooligosaccharides profile as that observed in sucrose reactions. We conclude that SacB has an intrinsic levanase activity that

  6. Nickel interactions with glutathione and related enzyme in 11-day embryo and yolk sac in rat

    Energy Technology Data Exchange (ETDEWEB)

    Serafini, M.T.; Romeu, A. (Univ. of Barcelona, Tarragona (Spain))

    1991-12-01

    The embryotoxicity and teratogenicity of nickel compounds has been observed in rats. Little is known about the biochemical mechanism(s) of Ni-teratogenesis. Furthermore, nickel induced a rapid, but transient rise in the serum glucose and changes in hormone balance in pregnant rats as well as metabolic changes in females. The purpose of this study was to characterize the effect of NiCl{sub 2} on glutathione and related enzymes in 11-day embryo and visceral yolk sac in rat.

  7. Contrast-enhanced MR imaging of the endolymphatic sac in patients with sudden hearing loss

    Energy Technology Data Exchange (ETDEWEB)

    Naganawa, Shinji; Koshikawa, Tokiko; Fukatsu, Hiroshi; Ishigaki, Takeo [Department of Radiology, Nagoya University School of Medicine (Japan); Nakashima, Tsutomu [Department of Otolayngology, Nagoya University School of Medicine (Japan); Ichinose, Nobuyasu [Toshiba Nasu Operations, Tochigi (Japan)

    2002-05-01

    Our objective was to evaluate the frequency of contrast enhancement of the endolymphatic sac in patients with sudden hearing loss. Forty consecutive patients with sudden sensorineural hearing loss (20 males and 20 females; age range 11-82 years), 40 age-matched control subjects, and 5 patients with Meniere's disease were examined using the same imaging protocol on a 1.5-T MR system. Pre- and post-contrast-enhanced T1-weighted 3D spoiled gradient-echo sequence (3D SPGR; TR/TE=23/10 ms, no. of excitations=1, flip angle=30 ) images were obtained using a voxel size of 0.6 x 0.7 x 0.8 mm{sup 3}. Contrast enhancement in the area of the endolymphatic sac was assessed by two radiologists, and the frequency of contrast enhancement was compared between the three study groups. Enhancement of the ipsilateral endolymphatic sac was observed in 30 of the 40 patients with sudden hearing loss (75%). Twenty of these 30 patients also showed enhancement on the contralateral side, and 1 patient showed enhancement only on the contralateral side. Only 1 of the 5 patients with Meniere's disease showed enhancement. Nine of the 40 control subjects (22.5%) showed enhancement (bilateral enhancement in 5 subjects, unilateral in 4). The frequency of enhancement in patients with sudden hearing loss was significantly higher than that in control subjects (P<0.0001) or patients with Meniere's disease (P<0.05). The frequency of contrast enhancement of the endolymphatic sac is significantly increased in patients with sudden hearing loss, but further study is necessary to clarify the relationship between this finding and the pathophysiology of sudden hearing loss. (orig.)

  8. Intercellular relations and wall structures in mature embryo sacs of four species of angiosperms

    Directory of Open Access Journals (Sweden)

    Monique Fougére-Rifot

    2014-01-01

    Full Text Available During the maturation process of an ovule, the internal walls of the embryo sac becomes gradually thinner from the poles to the central cell. The thinning process results in an association of two plasma membranes with no polysaccharide structure betwen them. The presence of one disymmetrical ER cistern along the walls during the thinning process permits to anticipate a turn-over of carbohydrates.

  9. Pericardial sac perforation: a rare complication of neonatal nasogastric tube feeding

    Energy Technology Data Exchange (ETDEWEB)

    El-Din Mahmoud Hanafy, Emad; Al Naqeeb, Niran [Al-Adan Hospital, Neonatal ICU, Department of Paediatrics, Hawally (Kuwait); Ashebu, Samuel D.; Bopaya Nanda, Harini [Al-Adan Hospital, Department of Diagnostic Radiology and Imaging, P.O. Box 43721, Hawally (Kuwait)

    2006-10-15

    The insertion of a nasogastric tube for feeding and gastric aspiration is a common practice in the care of newborns, especially if they are preterm and unwell. Esophageal perforation is a rare but serious complication of this procedure. Associated perforation of the pericardial sac is an unusual, severe, and previously unreported complication of nasogastric tube feeding in a neonate. We present an illustrative case. (orig.)

  10. Appendiceal pus in a hernia sac simulating strangulated femoral hernia: a case report

    OpenAIRE

    Hsiao, Tien-Fa; Chou,

    2011-01-01

    Tien-Fa Hsiao, Yenn-Hwei ChouDepartment of Surgery, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, TaiwanAbstract: Acute appendicitis involving the hernia sac is infrequent but well-documented in medical literature. In most instances, it occurs within the right inguinal (Amyand’s hernia) or right femoral hernia (de Garengeot hernia). The diagnosis is always mistaken for incarcerated groin hernia. During surgery, the appendix itself, either perforated or strangulated, is most commonly...

  11. Macrofauna community inside and outside of the Darwin Mounds SAC, NE Atlantic

    Directory of Open Access Journals (Sweden)

    N. Serpetti

    2012-11-01

    Full Text Available Over the past two decades, growing concerns have been raised regarding the effects of towed fishing gears, such as trawls and dredges, on deep-sea biodiversity and ecosystem functioning. Trawling disturbs the benthic communities both physically and biologically, and can eliminate the most vulnerable organisms and modify habitat structure; chronically disturbed communities are often dominated by opportunistic species. The European Union is under obligation to designate a network of offshore Special Areas of Conservation (SACs and Marine Protected Areas (MPAs by the end of 2012 based on the perceived expectation that these networks will help protect marine biodiversity and that within these areas, faunal abundance and diversity will be higher than the surrounding fished areas.

    The Darwin Mounds, only discovered in 1998, are located in the Rockall Trough, NE Atlantic at a depth of ~ 1000 m. Deep-water trawling regularly took place in the region of the Darwin Mounds; however in 2004 the mounds were designated as the first offshore SAC in UK and the area is now closed to bottom trawling. As part of the HERMIONE programme the influence of human impact on the Oceans was one of the key themes and in June 2011, an investigation of the macrofaunal community structure at comparable sites both inside and outside of the Darwin Mound SAC was undertaken. Macrofaunal communities were found to differ significantly, with the difference mostly driven by changes in the abundance of polychaetes, crustaceans and nematodes whilst no significant differences were seen for the other phyla. Whereas overall macrofaunal abundance was higher outside the SAC compared to within, this pattern varies considerably between phyla. Diversity indices showed no significant differences between protected and unprotected sites. This could indicate that a few years of preservation are not enough time to determine a recovery by the macrofaunal community of cold-water ecosystems

  12. Differential gene expression profiles in the venom gland/sac of Eumenes pomiformis (Hymenoptera: Eumenidae).

    Science.gov (United States)

    Baek, Ji Hyeong; Lee, Si Hyeock

    2010-06-01

    To search for novel transcripts encoding biologically active venom components, a subtractive cDNA library specific to the venom gland and sac (gland/sac) of a solitary hunting wasp species, Eumenes pomiformis Fabricius (1781), was constructed by suppression subtractive hybridization. A total of 541 expressed sequence tags (ESTs) were clustered and assembled into 102 contigs (31 multiple sequences and 71 singletons). In total, 37 cDNAs were found in the library via BLASTx searching and manual annotation. Eight contigs (337 ESTs) encoding short venom peptides (10 to 16 amino acids) occupied 62% of the library. The deduced amino acid sequence (78 amino acids) of a novel venom peptide transcript shared sequence similarity with trypsin inhibitors and dendrotoxin-like venom peptides known to be K(+) channel blockers, implying that this novel peptide may play a role in the paralysis of prey. In addition to phospholipase A2 and hyaluronidase, which are known to be the main components of wasp venoms, several transcripts encoding enzymes, including three metallopeptidases and a decarboxylase likely involved in the processing and activation of venomous proteins, peptides, amines, and neurotransmitters, were also isolated from the library. The presence of a transcript encoding a putative insulin/insulin-like peptide binding protein suggests that solitary hunting wasps use their venom to control their prey, leading to larval growth cessation. The abundance of these venom components in the venom gland/sac and in the alimentary canal was confirmed by quantitative real-time PCR. Discovery of venom gland/sac-specific transcripts should promote further studies on biologically active components in the venom of solitary hunting wasps.

  13. Morphological specializations of the yolk sac for yolk processing in embryonic corn snakes (Pantherophis guttatus: Colubridae).

    Science.gov (United States)

    Powers, Kathryn G; Blackburn, Daniel G

    2017-03-23

    Non-avian reptiles commonly are assumed to be like birds in their overall patterns of development. However, colubrid corn snakes (Pantherophis guttatus) have mechanisms of yolk cellularization and processing that are entirely different from the avian pattern. In birds, a vascular "yolk sac" surrounds and digests the liquid yolk. In contrast, in corn snakes, the yolk material is converted into vascularized cords of yolk-filled cells. In this study, we used stereomicroscopy, histology, and scanning electron microscopy to analyze this unusual developmental pattern in corn snakes. Our observations reveal that the yolk sac cavity is invaded by endodermal cells that proliferate, absorb yolk spheres, and form aggregates of interconnected cells within the liquid yolk mass. As development proceeds, small blood vessels arise from the yolk sac omphalopleure, penetrate into the yolk mass, and become tightly encased in the endodermal cells. The entire vitellus ultimately becomes converted into a mass of vascularized, "spaghetti-like" strands of yolk-laden cells. The resulting arrangement allows yolk to be digested intracellularly and yolk products to be transported to the developing embryo. Indirect evidence for this pattern in other species raises the possibility that it is ancestral for squamates and quite possibly Reptilia in general.

  14. Evaluation of Refractivity Profiles from CHAMP and SAC-C GPS Radio Occultation

    Science.gov (United States)

    Poli, Paul; Ao, Chi On; Joiner, Joanna; delaTorreJuarez, Manuel; Hoff, Raymond

    2002-01-01

    The GeoForschungsZentrum's Challenging Minisatellite Payload for Geophysical Research and Application (CHAMP, Germany-US) and the Comision Nacional de Actividades Especiales' Satelite de Aplicaciones Cientificas-C (SAC-C, Argentina-US) missions are the first missions to carry a second-generation Blackjack Global Positioning System (GPS) receiver. One of the new features of this receiver is its ability to sense the lower troposphere closer to the surface than the proof-of-concept GPS Meteorology experiment (GPS/MET). Since their launch, CHAMP and SAC-C have collected thousands of GPS radio occultations, representing a wealth of measurements available for data assimilation and Numerical Weather Prediction (NWP). In order to evaluate the refractivity data derived by the Jet Propulsion Laboratory (JPL) from raw radio occultation measurements, we use Data Assimilation Office (DAO) 6-hour forecasts as an independent state of the atmosphere. We compare CHAMP and SAC-C refractivity (processed by JPL) with refractivity calculated from the DAO global fields of temperature, water vapor content and humidity. We show statistics of the differences as well as histograms of the differences.

  15. Failure of aneurysm sac shrinkage after endovascular repair; the effect of mural calcification

    Energy Technology Data Exchange (ETDEWEB)

    Love, M. [Department of Radiology, Royal Victoria Hospital, Belfast (United Kingdom)]. E-mail: mark.love@royalhospitals.n-i.nhs.uk; Wray, A. [Department of Radiology, Royal Victoria Hospital, Belfast (United Kingdom); Worthington, M. [Department of Radiology, Royal Victoria Hospital, Belfast (United Kingdom); Ellis, P. [Department of Radiology, Royal Victoria Hospital, Belfast (United Kingdom)

    2005-12-15

    AIM: To evaluate the effect of abdominal aortic aneurysm wall calcification on subsequent sac shrinkage after endovascular repair. MATERIALS AND METHODS: Seventy-three patients underwent endovascular aneurysm repair. The degree of sac wall calcification on pre-procedural computed tomography (CT) examination was graded from 1 to 4 according to the degree of circumferential involvement. On follow-up CT imaging, the maximum transverse diameter (MTD) of the sac was recorded, as well as the presence or absence of endoleak. In those patients with a non-shrinking aneurysm, but no CT evidence of endoleak, contrast-enhanced ultrasound (USS) was performed. Any patient with an endoleak, however diagnosed, was excluded from the study. Kruskal-Wallis and Spearman's rank correlation coefficient testing was applied to compare the degree of calcification and change in MTD. RESULTS: Sixty-three pre-procedural CT images were available for calcification grading. Six of this group had endoleaks resulting in 57 sets of data being available for the study. A reduction in MTD occurred in 68.25% of these patients by 1 year post-procedure. Our figures show aortic calcification is inversely associated with MTD reduction at 6 months (p=0.01), 1 year (p=0.05) and 2 years (p=0.05). CONCLUSION: This study indicates that the degree of aortic wall calcification is significant in predicting MTD reduction post-endovascular repair. The possible mechanisms and implications of this are discussed.

  16. Oil rigging firm to add 50 engineering vessels

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    China Oilfield Services Ltd., the oil service unit of the State-owned offshore oil and gas producer China NationalOffshore Oil Corporation, plans to add 50 vessels to its ocean engineering fleet, according to Cai Dian, manager of the shipping department at COSL. COSL is China's largest integrated oilfield service provider, operating a fleet of 108 vessels, which accounts for 60 percent of China's total ocean engineering vessel number.

  17. Add-on unidirectional elastic metamaterial plate cloak.

    Science.gov (United States)

    Lee, Min Kyung; Kim, Yoon Young

    2016-02-10

    Metamaterial cloaks control the propagation of waves to make an object invisible or insensible. To manipulate elastic waves in space, a metamaterial cloak is typically embedded in a base system that includes or surrounds a target object. The embedding is undesirable because it structurally weakens or permanently alters the base system. In this study, we propose a new add-on metamaterial elastic cloak that can be placed over and mechanically coupled with a base structure without embedding. We designed an add-on type annular metamaterial plate cloak through conformal mapping, fabricated it and performed cloaking experiments in a thin-plate with a hole. Experiments were performed in a thin plate by using the lowest symmetric Lamb wave centered at 100 kHz. As a means to check the cloaking performance of the add-on elastic plate cloak, possibly as a temporary stress reliever or a so-called "stress bandage", the degree of stress concentration mitigation and the recovery from the perturbed wave field due to a hole were investigated.

  18. An unusual mixed germ cell tumor of the testis consisting of rhabdomyosarcoma, mature teratoma and yolk sac tumor

    Institute of Scientific and Technical Information of China (English)

    Eva Lovri(c); Dubravka Bobonj Hi(z)ak; Melita Peri(c) Balja; Tanja Leni(c)ek; Bo(z)o Kru(s)lin

    2010-01-01

    @@ Dear Editor, We recently encountered a rare case of testicular mixed germ cell tumor (MGCT) in a 32-year-old man. The tumor was composed of a combination of a yolk sac tumor, teratoma and rhabdomyosarcomatous somatic type malignancy.

  19. Abnormalities Occurring during Female Gametophyte Development Result in the Diversity of Abnormal Embryo Sacs and Leads to Abnormal Fertilization in indicaljaponica Hybrids in Rice

    Institute of Scientific and Technical Information of China (English)

    Yu-Xiang Zeng; Chao-Yue Hu; Yong-Gen Lu; Jin-Quan Li; Xiang-Dong Liu

    2009-01-01

    Embryo sac abortion is one of the major masons for sterility in indicaljaponica hybrids In rice. To clarify the causal mechanism of embryo sac abortion, we studied the female gametophyte development in two indicaljaponica hybrids via an eosin B staining procedure for embryo sac scanning using confocal laser scanning microscope. Different types of abnormalities occurred during megasporogenesis and megagamatogenesis were demonstrated. The earliest abnormality was observed in the megasporocyte. A lot of the chalazal-most megaspores were degenerated before the mono-nucleate embryo sac stage. Disordered positioning of nucleus and abnormal nucallus tissue were characteristics of the abnormal female gametes from the mono-nucleate to four-nucleate embryo sac stages. The abnormalities that occurred from the early stage of the eight-nucleate embryo sac development to the mature embryo sac stage were characterized by smaller sizes and wrinkled antipodals. Asynchronous nuclear migration, abnormal positioning of nucleus, and degeneration of egg apparatus were also found at the eight-nucleate embryo sac stage. The abnormalities that occurred during female gametophyte development resulted in five major types of abnormal embryo sacs. These abnormal embryo sacs led to abnormal fertilization. Hand pollination using normal pollens on the spikelets during anthesis showed that normal pollens could not exclude the effect of abnormal embryo sac on seed setting.

  20. GPS radio occultation with CHAMP and SAC-C: global monitoring of thermal tropopause parameters

    Directory of Open Access Journals (Sweden)

    T. Schmidt

    2005-01-01

    Full Text Available In this study the global lapse-rate tropopause (LRT pressure, temperature, potential temperature, and sharpness are discussed based on Global Positioning System (GPS radio occultations (RO from the German CHAMP (CHAllenging Minisatellite Payload and the U.S.-Argentinian SAC-C (Satelite de Aplicaciones Cientificas-C satellite missions. Results with respect to seasonal variations are compared with operational radiosonde data and ECMWF (European Centre for Medium-Range Weather Forecast operational analyses. Results on the tropical quasi-biennial oscillation (QBO are updated from an earlier study. CHAMP RO data are available continuously since May 2001 with on average 150 high resolution temperature profiles per day. SAC-C data are available for several periods in 2001 and 2002. In this study temperature data from CHAMP for the period May 2001-December 2004 and SAC-C data from August 2001-October 2001 and March 2002-November 2002 were used, respectively. The bias between GPS RO temperature profiles and radiosonde data was found to be less than 1.5K between 300 and 10hPa with a standard deviation of 2-3K. Between 200-20hPa the bias is even less than 0.5K (2K standard deviation. The mean deviations based on 167699 comparisons between CHAMP/SAC-C and ECMWF LRT parameters are (-2.1±37.1hPa for pressure and (0.1±4.2K for temperature. Comparisons of LRT pressure and temperature between CHAMP and nearby radiosondes (13230 resulted in (5.8±19.8hPa and (-0.1±3.3K, respectively. The comparisons between CHAMP/SAC-C and ECMWF show on average the largest differences in the vicinity of the jet streams with up to 700m in LRT altitude and 3K in LRT temperature, respectively. The CHAMP mission generates the first long-term RO data set. Other satellite missions will follow (GRACE, COSMIC, MetOp, TerraSAR-X, EQUARS generating together some thousand temperature profiles daily.

  1. Immunohistochemical expression of SALL4 in hepatocellular carcinoma, a potential pitfall in the differential diagnosis of yolk sac tumors.

    Science.gov (United States)

    Gonzalez-Roibon, Nilda; Katz, Betina; Chaux, Alcides; Sharma, Rajni; Munari, Enrico; Faraj, Sheila F; Illei, Peter B; Torbenson, Michael; Netto, George J

    2013-07-01

    SALL4 is a transcription factor that serves as a marker of yolk sac tumor. Yolk sac tumor and hepatocellular carcinoma share histologic, serologic, and immunohistochemical features. Previous studies have shown lack of SALL4 expression in hepatocellular carcinoma, suggesting utility in this differential diagnosis. Sixty-nine samples of hepatocellular carcinoma were retrieved from surgical pathology archives and used to construct 9 tissue microarrays. A germ cell tumor tissue microarray containing 10 yolk sac tumors was used for comparison. Extent, intensity, and pattern of nuclear SALL4 expression were assessed in each spot. Mean percentage of expression was calculated for each tumor and used during analysis. Optimal discriminatory extent of expression cutoff was determined by receiver operating characteristic curve analysis. Other potential discriminatory markers including Hep Par1 were also evaluated. Forty-six percent (32/69) of hepatocellular carcinoma and all yolk sac tumors revealed at least focal expression of SALL4. A unique punctuate/clumped pattern of nuclear staining was present in 94% (30/32) of hepatocellular carcinoma, whereas all yolk sac tumors displayed a diffuse finely granular nuclear staining pattern. A 25% extent of SALL4 expression cutoff was found to be optimal for the distinction of yolk sac tumor from hepatocellular carcinoma yielding a sensitivity of 100%, specificity of 92.8%, and a positive predictive value of 66.6% for yolk sac tumor diagnosis. The addition of Hep Par1 increased the specificity (99%) and positive predictive value (90%). This is the first report of SALL4 expression in hepatocellular carcinoma. Our finding should be taken into consideration in the differential diagnosis of hepatocellular carcinoma and yolk sac tumor. The unique punctuate/clumped pattern seen in hepatocellular carcinoma cases could be of further discriminatory value.

  2. Ultrastructure of the endolymphatic sac in the larva of the japanese red-bellied newt Cynops pyrrhogaster

    Science.gov (United States)

    Gao, W.; Wiederhold, M.; Hejl, R.

    1998-01-01

    The ultrastructure of the endolymphatic sac (ES) of the late stage larva of the Japanese red-bellied newt, Cynops pyrrhogaster (stage 57), was examined by light and transmission electron microscopy. The two endolymphatic sacs are located at the dorsal-medial side of the otic vesicle on the dorsal-lateral side of the midbrain in the cranial cavity. The wall of the sac is composed of a layer of cubical epithelial cells with loose, interposed intercellular spaces. The sac contains a large luminal cavity, in which endolymph and numerous otoconia are present. The epithelial cells of different portions of the sac have a similar structure. These cells contain an abundance of cytoplasmic organelles, including ribosomes, Golgi complexes, and numerous vesicles. Two types of vesicles are found in the epithelial cells: the "floccular" vesicle and the "granular" vesicle. The floccular vesicles are located in the supra- and lateral-nuclear cytoplasm and contain floccular material. The granular vesicles have a fine granular substance and are usually situated apposed to the apical cell membrane. The granular vesicles are suggested to be secreted into the lumen, while the floccular vesicles are thought to be absorbed from the lumen and conveyed to the intercellular spaces by the epithelial cells. The apical surfaces of the epithelial cells bear numerous microvilli. Apparently floating cells, which bear long microvilli on the free surfaces, are observed in the lumen of the ES. Based on the fine structure, the function of the endolymphatic sac of the newt Cynops pyrrhogaster is discussed.

  3. Using patient lists to add value to integrated data repositories.

    Science.gov (United States)

    Wade, Ted D; Zelarney, Pearlanne T; Hum, Richard C; McGee, Sylvia; Batson, Deborah H

    2014-12-01

    Patient lists are project-specific sets of patients that can be queried in integrated data repositories (IDR's). By allowing a set of patients to be an addition to the qualifying conditions of a query, returned results will refer to, and only to, that set of patients. We report a variety of use cases for such lists, including: restricting retrospective chart review to a defined set of patients; following a set of patients for practice management purposes; distributing "honest-brokered" (deidentified) data; adding phenotypes to biosamples; and enhancing the content of study or registry data. Among the capabilities needed to implement patient lists in an IDR are: capture of patient identifiers from a query and feedback of these into the IDR; the existence of a permanent internal identifier in the IDR that is mappable to external identifiers; the ability to add queryable attributes to the IDR; the ability to merge data from multiple queries; and suitable control over user access and de-identification of results. We implemented patient lists in a custom IDR of our own design. We reviewed capabilities of other published IDRs for focusing on sets of patients. The widely used i2b2 IDR platform has various ways to address patient sets, and it could be modified to add the low-overhead version of patient lists that we describe.

  4. Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm.

    Science.gov (United States)

    Wallingford, Mary C; Giachelli, Cecilia M

    2014-08-01

    PiT-1 protein is a transmembrane sodium-dependent phosphate (Pi) transporter. PiT-1 knock out (KO) embryos die from largely unknown causes by embryonic day (E) 12.5. We tested the hypothesis that PiT-1 is required for endocytosis in the embryonic yolk sac (YS) visceral endoderm (VE). Here we present data supporting that PiT-1 KO results in a YS remodeling defect and decreased endocytosis in the YS VE. The remodeling defect is not due to an upstream cardiomyocyte requirement for PiT-1, as SM22αCre-specific KO of PiT-1 in the developing heart and the YS mesodermal layer (ME) does not recapitulate the PiT-1 global KO phenotype. Furthermore, we find that high levels of PiT-1 protein localize to the YS VE apical membrane. Together these data support that PiT-1 is likely required in YS VE. During normal development maternal immunoglobulin (IgG) is endocytosed into YS VE and accumulates in the apical side of the VE in a specialized lysosome termed the apical vacuole (AV). We have identified a reduction in PiT-1 KO VE cell height and a striking loss of IgG accumulation in the PiT-1 KO VE. The endocytosis genes Tfeb, Lamtor2 and Snx2 are increased at the RNA level. Lysotracker Red staining reveals a loss of distinct AVs, and yolk sacs incubated ex vivo with phRODO Green Dextran for Endocytosis demonstrate a functional loss of endocytosis. As yolk sac endocytosis is controlled in part by microautophagy, but expression of LC3 had not been examined, we investigated LC3 expression during yolk sac development and found stage-specific LC3 RNA expression that is predominantly from the YS VE layer at E9.5. Normalized LC3-II protein levels are decreased in the PiT-1 KO YS, supporting a requirement for PiT-1 in autophagy in the YS. Therefore, we propose the novel idea that PiT-1 is central to the regulation of endocytosis and autophagy in the YS VE.

  5. Basement membrane heparan sulfate proteoglycan from the L2 rat yolk sac carcinoma

    DEFF Research Database (Denmark)

    Fenger, M; Wewer, U; Albrechtsen, R

    1984-01-01

    Heparan sulfate proteoglycan from the L2 rat yolk sac carcinoma has been purified and partially characterized. The proteoglycan has an apparent Mr of 750 000, 35% of which represents the core protein. The core protein seems to be homogeneous, whereas the heparan sulfate chains are heterogeneous w...... with an Mr of about 50 000-70 000, with 30% of the glucosamine being N-sulfated. Antibodies raised against the core protein of the heparan sulfate proteoglycan reacted with basement membranes of various rat and human tissue....

  6. Use of inverted intestinal sacs to assess the effect of gastrointestinal insult on carcinogen absorption.

    Science.gov (United States)

    Capel, I D; Cosier, R S; Pinnock, M H; Williams, D C

    1981-01-01

    Rats were subjected to various forms of treatment in the manner likely to induce gastrointestinal insult. These and control animals were sacrificed and, using inverted sacs, the rate of absorption of either dimethylnitrosamine and benzo(a)pyrene determined. The gastrointestinal injury resulting from the differing treatments did not significantly affect the absorption of benzo(a)pyrene, whereas that of dimethylnitrosamine was significantly increased after each incubation time, most notably by alcohol pretreatment. The results demonstrate that intestinal damage increases the absorption of some carcinogens.

  7. De Garengeot's hernia: a case of acute appendicitis in a femoral hernia sac.

    Science.gov (United States)

    Tanrıkulu, Ceren Sen; Tanrıkulu, Yusuf; Akkapulu, Nezih

    2013-07-01

    The presence of an appendix vermiformis in a femoral hernia sac is called De Garengeot's hernia. It is a very rare clinical condition and requires emergency surgery. However, preoperative diagnosis of De Garengeot's hernia is difficult. Herein, we report a 58-year-old female who presented with sudden-onset painful swelling in the right groin region. Diagnosis was established based on computed tomography findings, and appendectomy with mesh-free hernia repair was performed. The postoperative period was uneventful, and the histopathologic examination of the specimen revealed gangrenous appendicitis.

  8. [The problems of yolk sac tumor morphogenesis in a light of the tumor stem cell theory].

    Science.gov (United States)

    Karseladze, A I

    2011-01-01

    The analysis of possible morphogenesis of the different structures in human yolk sac tumor has been considered. The author has supposed that features of blood vessel microarchitecture formation and perpetual differentiation of tumor cells or theirs functional modification play a crucial role in the morphogenesis of YST. The immunohistochemical investigation of some stem cells markers has showed the necessity of accounting of their distribution pattern in various cellular structures for the differential diagnosis of morphogenetical steps of YST. The growth of tumor cells differentiation rate correlates with increasing of stem cells markers expression as well c-kit > OCT4 > CD30 > PLAP.

  9. Basement membrane heparan sulfate proteoglycan from the L2 rat yolk sac carcinoma

    DEFF Research Database (Denmark)

    Fenger, M; Wewer, U; Albrechtsen, R

    1984-01-01

    Heparan sulfate proteoglycan from the L2 rat yolk sac carcinoma has been purified and partially characterized. The proteoglycan has an apparent Mr of 750 000, 35% of which represents the core protein. The core protein seems to be homogeneous, whereas the heparan sulfate chains are heterogeneous...... with an Mr of about 50 000-70 000, with 30% of the glucosamine being N-sulfated. Antibodies raised against the core protein of the heparan sulfate proteoglycan reacted with basement membranes of various rat and human tissue....

  10. 用.NET开发SolidWorks Add-in%The development of SolidWorks Add-in in .NET

    Institute of Scientific and Technical Information of China (English)

    阳程; 戴跃洪; 林夏斌

    2006-01-01

    分析. NET平台下非托管SolidWorks COM组件访问的技术原理,对该平台下SolidWorks COM对象向SolidWorks PIA对象模型转变的规则作了比较详细的归纳总结.并运用实例阐述在. NET环境下开发SolidWorks Add-in的实现过程与步骤,以期为在. NET平台下进行SolidWorks的二次开发与研究起到探索的作用.

  11. 78 FR 63878 - Approval and Promulgation of Air Quality Implementation Plans; Virginia; Revised Ambient Air...

    Science.gov (United States)

    2013-10-25

    ... Ambient Air Quality Standards for Fine Particulate Matter AGENCY: Environmental Protection Agency (EPA... Commonwealth of Virginia State Implementation Plan (SIP). The revisions add ambient air quality standards and... National Ambient Air Quality Standards (NAAQS) for PM 2.5 . EPA is approving these revisions in...

  12. Mth10b, a unique member of the Sac10b family, does not bind nucleic acid.

    Directory of Open Access Journals (Sweden)

    Yan-Feng Liu

    Full Text Available The Sac10b protein family is regarded as a group of nucleic acid-binding proteins that are highly conserved and widely distributed within archaea. All reported members of this family are basic proteins that exist as homodimers in solution and bind to DNA and/or RNA without apparent sequence specificity in vitro. Here, we reported a unique member of the family, Mth10b from Methanobacterium thermoautotrophicum ΔH, whose amino acid sequence shares high homology with other Sac10b family proteins. However, unlike those proteins, Mth10b is an acidic protein; its potential isoelectric point is only 4.56, which is inconsistent with the characteristics of a nucleic acid-binding protein. In this study, Mth10b was expressed in Escherichia coli and purified using a three-column chromatography purification procedure. Biochemical characterization indicated that Mth10b should be similar to typical Sac10b family proteins with respect to its secondary and tertiary structure and in its preferred oligomeric forms. However, an electrophoretic mobility shift analysis (EMSA showed that neither DNA nor RNA bound to Mth10b in vitro, indicating that either Mth10b likely has a physiological function that is distinct from those of other Sac10b family members or nucleic acid-binding ability may not be a fundamental factor to the actual function of the Sac10b family.

  13. 77 FR 59610 - Flonicamid; Applications To Add New Food Uses on Previously Registered Pesticide Products

    Science.gov (United States)

    2012-09-28

    ... applications to add new food uses on previously registered pesticide products containing the insecticide... registered pesticide products containing the insecticide, flonicamid, N-(cyanomethyl)-4-(trifluoromethyl)-3... AGENCY Flonicamid; Applications To Add New Food Uses on Previously Registered Pesticide Products...

  14. Symbolic BDD and ADD Algorithms for Energy Games

    Directory of Open Access Journals (Sweden)

    Shahar Maoz

    2016-11-01

    Full Text Available Energy games, which model quantitative consumption of a limited resource, e.g., time or energy, play a central role in quantitative models for reactive systems. Reactive synthesis constructs a controller which satisfies a given specification, if one exists. For energy games a synthesized controller ensures to satisfy not only the safety constraints of the specification but also the quantitative constraints expressed in the energy game. A symbolic algorithm for energy games, recently presented by Chatterjee et al., is symbolic in its representation of quantitative values but concrete in the representation of game states and transitions. In this paper we present an algorithm that is symbolic both in the quantitative values and in the underlying game representation. We have implemented our algorithm using two different symbolic representations for reactive games, Binary Decision Diagrams (BDD and Algebraic Decision Diagrams (ADD. We investigate the commonalities and differences of the two implementations and compare their running times on specifications of energy games.

  15. Add-on gabapentin in the treatment of opiate withdrawal.

    Science.gov (United States)

    Martínez-Raga, José; Sabater, Ana; Perez-Galvez, Bartolome; Castellano, Miguel; Cervera, Gaspar

    2004-05-01

    Gabapentin is an antiepileptic drug shown to be effective in the treatment of pain disorders and appears to be useful as well for several psychiatric disorders, including bipolar disorder, anxiety disorders, alcohol withdrawal and cocaine dependence. Gabapentin, at a dose of 600 mg three times a day, was evaluated as an add-on medication to a standard detoxification regime in seven heroin dependent individuals undergoing outpatient opiate withdrawal treatment. All seven patients successfully completed opiate detoxification and commenced opiate antagonist treatment with naltrexone on day five of withdrawal treatment, as scheduled. No adverse event was noted. Gabapentin appeared to lead a reduction in symptomatic medication and an overall beneficial effect on symptoms of heroin withdrawal.

  16. A subsurface add-on for standard atomic force microscopes

    Energy Technology Data Exchange (ETDEWEB)

    Verbiest, G. J., E-mail: Verbiest@physik.rwth-aachen.de [JARA-FIT and II. Institute of Physics, RWTH Aachen University, 52074 Aachen (Germany); Zalm, D. J. van der; Oosterkamp, T. H.; Rost, M. J., E-mail: Rost@physics.leidenuniv.nl [Kamerlingh Onnes Laboratory, Leiden University, P.O. Box 9504, 2300 RA Leiden (Netherlands)

    2015-03-15

    The application of ultrasound in an Atomic Force Microscope (AFM) gives access to subsurface information. However, no commercially AFM exists that is equipped with this technique. The main problems are the electronic crosstalk in the AFM setup and the insufficiently strong excitation of the cantilever at ultrasonic (MHz) frequencies. In this paper, we describe the development of an add-on that provides a solution to these problems by using a special piezo element with a lowest resonance frequency of 2.5 MHz and by separating the electronic connection for this high frequency piezo element from all other connections. In this sense, we support researches with the possibility to perform subsurface measurements with their existing AFMs and hopefully pave also the way for the development of a commercial AFM that is capable of imaging subsurface features with nanometer resolution.

  17. Non-invasive beamforming add-on module

    KAUST Repository

    Bader, Ahmed

    2017-02-23

    An embodiment of a non-invasive beamforming add-on apparatus couples to an existing antenna port and rectifies the beam azimuth in the upstream and downstream directions. The apparatus comprises input circuitry that is configured to receive one or more signals from a neighboring node of the linear wireless sensor network; first amplifier circuitry configured to adjust an amplitude of a respective received signal in accordance with a weighting coefficient and invoke a desired phase to a carrier frequency of the received signal thereby forming a first amplified signal; and second amplifier circuitry configured to adjust a gain of the first amplified signal towards upstream and downstream neighbors of the linear wireless sensor in the linear wireless sensor network.

  18. Performance Analysis of SAC Optical PPM-CDMA System-Based Interference Rejection Technique

    Science.gov (United States)

    Alsowaidi, N.; Eltaif, Tawfig; Mokhtar, M. R.

    2016-03-01

    In this paper, we aim to theoretically analyse optical code division multiple access (OCDMA) system that based on successive interference cancellation (SIC) using pulse position modulation (PPM), considering the interference between the users, imperfection cancellation occurred during the cancellation process and receiver noises. Spectral amplitude coding (SAC) scheme is used to suppress the overlapping between the users and reduce the receiver noises effect. The theoretical analysis of the multiple access interference (MAI)-limited performance of this approach indicates the influence of the size of M-ary PPM on OCDMA system. The OCDMA system performance improves with increasing M-ary PPM. Therefore, it was found that the SIC/SAC-OCDMA system using PPM technique along with modified prime (MPR) codes used as signature sequence code offers significant improvement over the one without cancellation and it can support up to 103 users at the benchmarking value of bit error rate (BER) = 10-9 with prime number p = 11 while the system without cancellation scheme can support only up to 52 users.

  19. Metastatic anal sac carcinoma with hypercalcaemia and associated hypertrophic osteopathy in a dog

    Directory of Open Access Journals (Sweden)

    A. Giuliano

    2015-05-01

    Full Text Available A seven-year-old male neutered Irish setter was treated for a metastatic anal sac adenocarcinoma (ASAC and hypercalcaemia by complete surgical excision of the primary tumour and partial excision of the sublumbar lymph nodes. Further enlargement of the sublumbar lymph nodes was linked to recurrent hypercalcaemia 3 months after surgical treatment. Medical treatment with Toceranib and Clodronate showed modest results in the treatment of the tumour and the hypercalcaemia. Radiotherapy of the sublumbar lymph nodes and later concurrent carboplatin chemotherapy resulted in partial tumour remission with marked reduction in size of the lymph nodes and normalization of the calcaemia. Unfortunately, concurrently with subsequent relapse of the hypercalaemia, the dog developed hypertrophic osteopathy (HO and lumbar spinal metastasis and the dog was euthanized. To the authors’ knowledge, this is the second case of metastatic apocrine gland carcinoma of the anal sac associated with HO and the first case that describe the development of HO late in the stage of the disease.

  20. Radiographic anatomy of the distal dural SAC; A myelographic investigation of dimensions and termination

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, J.L.; Olsen, K.O. (Haukeland Sykehus, Bergen (Norway). Dept. of Diagnostic Radiology)

    1991-05-01

    A radio-anatomical study was performed of the distal dural sac (DS) in 121 patients subjected to myelography. In 83.4% the termination of the DS was located from the upper half of the S1-segment to the lower half of the S2-segment. In the remaining patients the dural terminations were more distally located. The average location of the DS-termination was higher than that found in a previous anatomic study. The inference is that in patients with low-back pain and sciatica, the DS tends to terminate at a higher spinal level than in a non-selected anatomic material. The caudal reduction in sagittal diameter of the DS was less than that of the frontal diameter of the sac. The linear diminution in cross-sectional area of the DS from the level of L3 towards the lumbosacral junction was not correlated with the degree of caudal extension of the DS into the sacrum. Thus the length of the DS and its transverse diameters are independent of each other. These results supported the view that the location of the termination of the DS (and hence that of the spinal cord) is not related to stenosis of the central spinal canal. (orig.).

  1. From embryo sac to oil and protein bodies: embryo development in the model legume Medicago truncatula.

    Science.gov (United States)

    Wang, Xin-Ding; Song, Youhong; Sheahan, Michael B; Garg, Manohar L; Rose, Ray J

    2012-01-01

    • The cell and developmental biology of zygotic embryogenesis in the model legume Medicago truncatula has received little attention. We studied M. truncatula embryogenesis from embryo sac until cotyledon maturation, including oil and protein body biogenesis. • We characterized embryo development using light and electron microscopy, measurement of protein and lipid fatty acid accumulation and by profiling the expression of key seed storage genes. • Embryo sac development in M. truncatula is of the Polygonum type. A distinctive multicellular hypophysis and suspensor develops before the globular stage and by the early cotyledon stage, the procambium connects the developing apical meristems. In the storage parenchyma of cotyledons, ovoid oil bodies surround protein bodies and the plasma membrane. Four major lipid fatty acids accumulate as cotyledons develop, paralleling the expression of OLEOSIN and the storage protein genes, VICILIN and LEGUMIN. • Zygotic embryogenesis in M. truncatula features the development of a distinctive multicellular hypophysis and an endopolyploid suspensor with basal transfer cell. A clear procambial connection between the apical meristems is evident and there is a characteristic arrangement of oil bodies in the cotyledons and radicle. Our data help link embryogenesis to the genetic regulation of oil and protein body biogenesis in legume seed.

  2. Squamous cell carcinoma of the anal sac in a spotted hyena (Crocuta crocuta).

    Science.gov (United States)

    Goodnight, Andrea L; Traslavina, Ryan P; Emanuelson, Karen; Affolter, Verena K; Gaffney, Patricia M; Vernau, William; Williams, Colette; Wu, Connie I-kuan; Sturges, Beverly K; Lowenstine, Linda J

    2013-12-01

    A 25-yr-old spayed female spotted hyena (Crocuta crocuta) developed intermittent right pelvic limb lameness that persisted following conservative medical therapy. No obvious musculoskeletal lesions were noted on initial physical exam; however, spinal radiography was suspicious for possible intervertebral degenerative joint disease or discospondylitis. Despite prolonged medical therapy, the lameness progressed to minimal weight bearing and marked muscle atrophy of the right pelvic limb. Electromyography showed spontaneous activity in the muscles of right sciatic nerve distribution. Sensory and motor nerve conduction velocities in the right tibial and peroneal nerves were undetectable and markedly reduced, respectively. A magnetic resonance imaging (MRI) scan revealed a large, space-occupying mass on the right side of the sacrum and pelvis. Antemortem fine-needle aspiration of the mass and postmortem histopathology resulted in diagnosis of a high-grade squamous cell carcinoma of the anal sac. Squamous cell carcinoma of the anal sac is very rare in domestic dogs and previously unreported in spotted hyenas.

  3. An add-on system including a micro-reactor for an atr-ir spectrometer

    DEFF Research Database (Denmark)

    2014-01-01

    The invention relates to an add-on system for an attenuated total reflectance infrared (ATR-IR) spectrometer, the add-on system allowing for time-resolved in situ IR measurements of heterogeneous mixtures. The add-on device comprises a micro-reactor (300A) forming a sample cavity (305) when...

  4. An add-on system for photochemical ATR-IR spectroscopy studies

    DEFF Research Database (Denmark)

    2014-01-01

    The invention relates to an add-on system for a unit mainly adapted for attenuated total reflectance infrared (ATR-IR) spectroscopy. The add-on system enables time-resolved in-situ measurements of different sample types in an easy, simple and inexpensive way. The add-on system includes a cap (300G...

  5. Les rivières et les sources de la Plaine du Cul-de-Sac: extrait du rapport sur les eaux souterraines de la Plaine du Cul-de-Sac

    Science.gov (United States)

    Taylor, George C.; Lemoine, Rémy C.

    1949-01-01

    Les principales rivières de la Plaine du Cul-de-Sac, la Rivière Grise ou Grande Rivière du Cul-de-Sac et la Rivière Blanche, prennent naissance sur le flanc Nord du Massif de la Selle à des altitudes de 1,300 à 1,800 mètres au dessus du niveau de la mer. Elles coulent à l’amont à travers des gorges profondes et sont éloignées de 9 Kms. dans la partie central de la bordure Sud de la plaine.

  6. Endometrioid like yolk sac tumor of the testis with small teratomatous foci: A case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Prabir Hazarika

    2015-01-01

    Full Text Available I have reported a case of endometrioid like yolk sac tumor of the testis in a 20-year-old boy. Endometrioid like yolk sac tumor is a rare tumor. A few cases have been reported in ovary. In case of male, a case of pure glandular endometrioid like yolk sac tumor is reported in a 43 years male in right undescended testis and another case of abdominal metastasis showing endometrioid pattern from mixed testicular germ cell tumor comprising of teratoma and embryonal carcinoma. My patient was a 20-year-old male presented with painless enlargement of right testis. Grossly the tumor was glistening creamish white with a multicystic appearance. Histopathological examination showed the tumor to be composed of glandular elements resembling early secretory endometrium, foci of keratinized thin squamous epithelium and a single focus of benign cartilage. The glandular elements show immunohistochemical positivity for AFP, cytokeratin 7 (CK7 and epithelial membrane antigen (EMA.

  7. Characteristics of indomethacin-saccharin (IMC-SAC) co-crystals prepared by an anti-solvent crystallization process.

    Science.gov (United States)

    Chun, Nan-Hee; Wang, In-Chun; Lee, Min-Jeong; Jung, Yun-Taek; Lee, Sangkil; Kim, Woo-Sik; Choi, Guang J

    2013-11-01

    The creation of co-crystals of various insoluble drug substances has been extensively investigated as a promising approach to improve their pharmaceutical performance. In this study, co-crystal powders of indomethacin and saccharin (IMC-SAC) were prepared by an anti-solvent (water) addition and compared with co-crystals by evaporation method. No successful synthesis of a pharmaceutical co-crystal powder via an anti-solvent approach has been reported. Among solvents examined, methanol was practically the only one that resulted in the formation of highly pure IMC-SAC co-crystal powders by anti-solvent approach. The mechanism of a preferential formation of IMC-SAC co-crystal to IMC was explained with two aspects: phase solubility diagram and solution complexation concept. Accordingly, the anti-solvent approach can be considered as a competitive route for producing pharmaceutical co-crystal powders with acceptable properties.

  8. Prevascular femoral hernia and its relation with inferior epigastric vessels: a rare presentation of the femoral hernia sac.

    Science.gov (United States)

    Boshnaq, Mohamed; Phan, Yih Chyn; Akhtar, Mansoor; Hamade, Ayman

    2016-04-18

    A 61-year-old man presented to the emergency department, with a 2-week history of a painful lump on his right groin. A diagnosis of an irreducible right femoral hernia was made. As such, an urgent operation was carried out on the same day, and the patient was found to have a rare prevascular femoral hernia in which the sac was lying over the femoral vessels and split by the inferior epigastric vessels into 2 components resembling 2 trouser limbs. The hernia sac presented in a different and challenging way that necessitated meticulous dissection and full orientation of the anatomy of the femoral triangle. Complete dissection and control of the inferior epigastric vessels, and complete reduction of the sac followed by repair with a prosthetic mesh plug were performed successfully. The patient was discharged home the next day.

  9. Altered callose deposition during embryo sac formation of multi-pistil mutant (mp1) in Medicago sativa.

    Science.gov (United States)

    Zhou, H C; Jin, L; Li, J; Wang, X J

    2016-06-03

    Whether callose deposition is the cause or result of ovule sterility in Medicago sativa remains controversial, because it is unclear when and where changes in callose deposition and dissolution occur during fertile and sterile embryo sac formation. Here, alfalfa spontaneous multi-pistil mutant (mp1) and wild-type plants were used to compare the dynamics of callose deposition during embryo sac formation using microscopy. The results showed that both mutant and wild-type plants experienced megasporogenesis and megagametogenesis, and there was no significant difference during megasporogenesis. In contrast to the wild-type plants, in which the mature embryo sac was observed after three continuous cycles of mitosis, functional megaspores of mutant plants developed abnormally after the second round of mitosis, leading to degeneration of synergid, central, and antipodal cells. Callose deposition in both mutant and wild-type plants was first observed in the walls of megasporocytes, and then in the megaspore tetrad walls. After meiosis, the callose wall began to degrade as the functional megaspore underwent mitosis, and almost no callose was observed in the mature embryo sac in wild-type plants. However, callose deposition was observed in mp1 plants around the synergid, and increased with the development of the embryo sac, and was mainly deposited at the micropylar end. Our results indicate that synergid, central, and antipodal cells, which are surrounded by callose, may degrade owing to lack of nutrition. Callose accumulation around the synergid and at the micropylar end may hinder signals required for the pollen tube to enter the embryo sac, leading to abortion.

  10. Histological analyses demonstrate the temporary contribution of yolk sac, liver, and bone marrow to hematopoiesis during chicken development.

    Directory of Open Access Journals (Sweden)

    Priscila Tavares Guedes

    Full Text Available The use of avian animal models has contributed to the understanding of many aspects of the ontogeny of the hematopoietic system in vertebrates. However, specific events that occur in the model itself are still unclear. There is a lack of consensus, among previous studies, about which is the intermediate site responsible for expansion and differentiation of hematopoietic cells, and the liver's contribution to the development of this system. Here we aimed to evaluate the presence of hematopoiesis in the yolk sac and liver in chickens, from the stages of intra-aortic clusters in the aorta-genital ridges-mesonephros (AGM region until hatching, and how it relates to the establishment of the bone marrow. Gallus gallus domesticus L. embryos and their respective yolk sacs at embryonic day 3 (E3 and up to E21 were collected and processed according to standard histological techniques for paraffin embedding. The slides were stained with hematoxylin-eosin, Lennert's Giemsa, and Sirius Red at pH 10.2, and investigated by light microscopy. This study demonstrated that the yolk sac was a unique hematopoietic site between E4 and E12. Hematopoiesis occurred in the yolk sac and bone marrow between E13 and E20. The liver showed granulocytic differentiation in the connective tissue of portal spaces at E15 and onwards. The yolk sac showed expansion of erythrocytic and granulocytic lineages from E6 to E19, and E7 to E20, respectively. The results suggest that the yolk sac is the major intermediate erythropoietic and granulopoietic site where expansion and differentiation occur during chicken development. The hepatic hematopoiesis is restricted to the portal spaces and represented by the granulocytic lineage.

  11. Relación entre atención selectiva y movimientos oculares sacádicos

    OpenAIRE

    Arguello-Vargas, Diana Karina

    2015-01-01

    La atención selectiva y los movimientos oculares sacádicos son fundamentales para el desarrollo del proceso de enseñanza-aprendizaje y para el rendimiento académico. Por esta razón, la presente investigación tiene por objetivo estudiar la relación entre atención selectiva y movimientos oculares sacádicos y proponer un programa de intervención, en una muestra de sesenta y tres niñas escolarizadas de cuarto y quinto de primaria, pertenecientes a un colegio privado de la ciudad de Bucaramanga y ...

  12. Expression and immunolocalisation of the endocytic receptors megalin and cubilin in the human yolk sac and placenta across gestation.

    Science.gov (United States)

    Burke, K A; Jauniaux, E; Burton, G J; Cindrova-Davies, T

    2013-11-01

    Megalin and cubilin are multifunctional endocytic receptors associated with many transporting epithelia. They play an essential role in transport of nutrients through the visceral yolk sac of rodents during embryogenesis. Here, we immunolocalise them to the endodermal layer of the human yolk sac, and to the syncytiotrophoblast and cytotrophoblast cells of placental villi. In villi, the protein level of both receptors increased with gestation. The mRNA for megalin remained constant, while that encoding cubilin increased with gestation. These results suggest megalin and cubilin may be important in human maternal-fetal transfer, and that they increase across gestation to facilitate this function.

  13. Primary Diffuse Large B-Cell Lymphoma Localized to the Lacrimal Sac: A Case Presentation and Review of the Literature

    OpenAIRE

    Kevin Zarrabi; Ved Desai; Brandom Yim; Gabig, Theodore G.

    2016-01-01

    We report a rare case of diffuse large B-cell lymphoma (DLBCL) of the lacrimal sac in a 50-year-old male. The incidence of primary ocular lymphoma is low and it is considered a rare disease. Moreover, reports of ocular DLBCL are uncommon and the disease remains poorly characterized. Our patient presented for management of osteomyelitis and was incidentally found to have a painless swelling and cyst around his right eye. A PET/CT scan revealed hypermetabolic activity within the lacrimal sac an...

  14. Complete chorioamniotic separation and persistence of a yolk sac associated with triploidy.

    Science.gov (United States)

    Erol, Onur; Erol, Melek; Karaca, Mehmet

    2013-10-01

    Contexte : La triploïdie est une pathologie grandement mortelle; ainsi, il est très rare d’en constater la présence dans le cadre d’une naissance vivante. Elle peut en venir à constituer un risque médical considérable pour la femme enceinte. Cas : Une femme multigravide de 32 ans a sollicité nos services pour l’obtention de soins prénataux. L’examen échographique mené à 14+3 semaines de gestation a révélé la présence d’un fœtus viable qui présentaient une biométrie fœtale appropriée, tout en indiquant également des signes de séparation chorioamniotique (CAS) et la persistance du sac vitellin. Deux semaines plus tard, la tenue d’un deuxième examen échographique a révélé la présence d’un large placenta multikystique et d’un retard de croissance fœtal symétrique précoce, en plus d’indiquer la persistance de la CAS et du sac vitellin, ce qui nous a menés à soupçonner la présence d’une aneuploïdie fœtale. L’amniocentèse a indiqué la présence d’un caryotype fœtal 69,XXX. L’histologie du tissu placentaire a indiqué qu’il s’agissait d’une môle hydatiforme partielle. Conclusion : La persistance de la séparation chorioamniotique et du sac vitellin aux débuts du deuxième trimestre ne peut être considérée comme étant une constatation rassurante. Dans de tels cas, la tenue d’un caryotypage fœtal devrait être envisagée, particulièrement lorsque la présence d’une autre anomalie est constatée.

  15. Does aquaculture add resilience to the global food system?

    Science.gov (United States)

    Troell, Max; Naylor, Rosamond L; Metian, Marc; Beveridge, Malcolm; Tyedmers, Peter H; Folke, Carl; Arrow, Kenneth J; Barrett, Scott; Crépin, Anne-Sophie; Ehrlich, Paul R; Gren, Asa; Kautsky, Nils; Levin, Simon A; Nyborg, Karine; Österblom, Henrik; Polasky, Stephen; Scheffer, Marten; Walker, Brian H; Xepapadeas, Tasos; de Zeeuw, Aart

    2014-09-16

    Aquaculture is the fastest growing food sector and continues to expand alongside terrestrial crop and livestock production. Using portfolio theory as a conceptual framework, we explore how current interconnections between the aquaculture, crop, livestock, and fisheries sectors act as an impediment to, or an opportunity for, enhanced resilience in the global food system given increased resource scarcity and climate change. Aquaculture can potentially enhance resilience through improved resource use efficiencies and increased diversification of farmed species, locales of production, and feeding strategies. However, aquaculture's reliance on terrestrial crops and wild fish for feeds, its dependence on freshwater and land for culture sites, and its broad array of environmental impacts diminishes its ability to add resilience. Feeds for livestock and farmed fish that are fed rely largely on the same crops, although the fraction destined for aquaculture is presently small (∼4%). As demand for high-value fed aquaculture products grows, competition for these crops will also rise, as will the demand for wild fish as feed inputs. Many of these crops and forage fish are also consumed directly by humans and provide essential nutrition for low-income households. Their rising use in aquafeeds has the potential to increase price levels and volatility, worsening food insecurity among the most vulnerable populations. Although the diversification of global food production systems that includes aquaculture offers promise for enhanced resilience, such promise will not be realized if government policies fail to provide adequate incentives for resource efficiency, equity, and environmental protection.

  16. Lixisenatide as add-on therapy to basal insulin

    Directory of Open Access Journals (Sweden)

    Brown DX

    2013-12-01

    Full Text Available Dominique Xavier Brown, Emma Louise Butler, Marc Evans Diabetes Department, University Hospital Llandough, Cardiff, UK Abstract: Many patients with type 2 diabetes mellitus do not achieve target glycosylated hemoglobin A1c levels despite optimally titrated basal insulin and satisfactory fasting plasma glucose levels. Current evidence suggests that HbA1c levels are dictated by both basal glucose and postprandial glucose levels. This has led to a consensus that postprandial glucose excursions contribute to poor glycemic control in these patients. Lixisenatide is a once-daily, prandial glucagon-like peptide 1 (GLP-1 receptor agonist with a four-fold affinity for the GLP-1 receptor compared with native GLP-1. Importantly, lixisenatide causes a significant delay in gastric emptying time, an important determinant of the once-daily dosing regimen. An exendin-4 mimetic with six lysine residues removed at the C-terminal, lixisenatide has pronounced postprandial glucose-lowering effects, making it a novel incretin agent for use in combination with optimally titrated basal insulin. Lixisenatide exerts profound effects on postprandial glucose through established mechanisms of glucose-dependent insulin secretion and glucagon suppression in combination with delayed gastric emptying. This review discusses the likely place that lixisenatide will occupy in clinical practice, given its profound effects on postprandial glucose and potential to reduce glycemic variability. Keywords: lixisenatide, add-on therapy, insulin, GLP-1 receptor agonist, postprandial glucose, pharmacodynamics

  17. Pure yolk sac tumor of testis in a 50 years old : A rare case report

    Directory of Open Access Journals (Sweden)

    Pradhan M Pagaro

    2016-01-01

    Full Text Available Yolk sac tumor (YST is most common in infants and children in age range of 3-8 years in pure form; however in adults, YST rarely occurs in pure form, but commonly occurs in association with other germ cell tumors as mixed forms. Less than 10 adult testicular pure YSTs have been reported in literature. We report a 50-year-old male with testicular neoplasm involving the left testis, with pain following trauma. Alpha-fetoprotein was markedly raised 5726 IU/ml, and on histopathology, characteristic features of YST with abundant Schiller–Duval bodies associated with reticular and microcystic pattern, and focal solid areas of nests and trabeculae of cuboidal cells, with prominent nucleoli and mitotic figures, were noted, and extensive histopathological search did not reveal presence of any other type of tumor.

  18. Mediastinal Yolk Sac Tumor Producing Protein Induced by Vitamin K Absence or Antagonist-II.

    Science.gov (United States)

    Akutsu, Noriyuki; Adachi, Yasushi; Isosaka, Mai; Mita, Hiroaki; Takagi, Hideyasu; Sasaki, Shigeru; Yamamoto, Hiroyuki; Arimura, Yoshiaki; Ishii, Yoshifumi; Masumori, Naoya; Endo, Takao; Shinomura, Yasuhisa

    2015-01-01

    Extragonadal yolk sac tumors (YSTs) are rare. We herein report the case of a 66-year-old man with mediastinal, lung and liver tumors. The largest mass was located in the liver and contained a high concentration of protein induced by vitamin K absence or antagonist-II (PIVKA-II) and alpha-fetoprotein. Therefore, the lesion was difficult to distinguish from hepatocellular carcinoma. Finally, YST was diagnosed based on the results of a liver biopsy. Although chemotherapy was effective, the patient died of respiratory failure. The autopsy revealed primary mediastinal YST. In the current report, we describe this case of PIVKA-II-producing YST and review previous cases of PIVKA-II-producing tumors other than hepatoma.

  19. The fluid mechanics of a sac-type ventricular assist device.

    Science.gov (United States)

    Clark, C; Jin, W; Glaser, A

    1990-12-01

    Flow visualisation and velocity measurement studies have been carried out on the liquid side of a sac-type VAD. The objectives have been to identify both good (e.g. short residence times) and bad (e.g. high turbulence levels) flow characteristics. The flow was visualised using polystyrene micro-spheres illuminated with white light on selected transverse planes across the pumping chamber and its inlet and outlet connections. These results then served as a guide for velocity measurements using laser-Doppler anemometry. Flow tests were run using water or a water/glycerol mixture. Operating conditions were determined from the appropriate fluid mechanics modelling laws to ensure dynamical similarity. Initially, steady flow behaviour was investigated including the effects of removal and insertion of the tilting-disc inlet and outlet valves. In subsequent full pumping tests, using a pneumatic driver, regions of high shear, separation, and high turbulence intensity have been identified.

  20. Five new species of the Afrotropical dark sac spider genus Messapus Simon, 1898 (Araneae: Corinnidae).

    Science.gov (United States)

    Haddad, Charles R; Mbo, Zingisile

    2015-12-11

    The Afrotropical dark sac spider genus Messapus Simon, 1898 (Corinnidae: Corinninae) currently only comprises two described species, the type species M. martini Simon, 1898 and M. natalis (Pocock, 1898), which have both recently been redescribed. The leg and setal morphology of Messapus is studied using scanning electron microscopy for the first time, for M. martini and M. tigris sp. n., and additional characters are provided to supplement a recent generic description. Five new species are described in the current paper: M. megae sp. n. (♂ ♀, from Zimbabwe), M. meridionalis sp. n. (♀, from South Africa), M. seiugatus sp. n. (♀, from Guinea), M. tigris sp. n. (♀, from Botswana and Namibia), and M. tropicus sp. n. (♂ ♀, from Democratic Republic of the Congo). All five species are arboreal spiders occurring on bark, lower foliage strata and the canopies of forest and savannah trees. An identification key to the seven species of the genus is provided.

  1. PolySac3DB: an annotated data base of 3 dimensional structures of polysaccharides

    Directory of Open Access Journals (Sweden)

    Sarkar Anita

    2012-11-01

    Full Text Available Abstract Background Polysaccharides are ubiquitously present in the living world. Their structural versatility makes them important and interesting components in numerous biological and technological processes ranging from structural stabilization to a variety of immunologically important molecular recognition events. The knowledge of polysaccharide three-dimensional (3D structure is important in studying carbohydrate-mediated host-pathogen interactions, interactions with other bio-macromolecules, drug design and vaccine development as well as material science applications or production of bio-ethanol. Description PolySac3DB is an annotated database that contains the 3D structural information of 157 polysaccharide entries that have been collected from an extensive screening of scientific literature. They have been systematically organized using standard names in the field of carbohydrate research into 18 categories representing polysaccharide families. Structure-related information includes the saccharides making up the repeat unit(s and their glycosidic linkages, the expanded 3D representation of the repeat unit, unit cell dimensions and space group, helix type, diffraction diagram(s (when applicable, experimental and/or simulation methods used for structure description, link to the abstract of the publication, reference and the atomic coordinate files for visualization and download. The database is accompanied by a user-friendly graphical user interface (GUI. It features interactive displays of polysaccharide structures and customized search options for beginners and experts, respectively. The site also serves as an information portal for polysaccharide structure determination techniques. The web-interface also references external links where other carbohydrate-related resources are available. Conclusion PolySac3DB is established to maintain information on the detailed 3D structures of polysaccharides. All the data and features are available

  2. Embryo sac development in yellow passion fruit Passiflora edulis f. flavicarpa (Passifloraceae

    Directory of Open Access Journals (Sweden)

    Margarete Magalhães de Souza

    2002-01-01

    Full Text Available The yellow passion fruit, Passiflora edulis f. flavicarpa, is one of the most important Brazilian fruit crops. It is an allogamous, diploid, and self-incompatible species. It has hermaphrodite, solitary flowers, located in the leaf axils and protected by leaf bracts. The flower has an androgynophore, which is a straight stalk supporting its reproductive parts. There are usually five anthers, located at the tip of each of the five filaments. The ovary is borne just above the filaments, at the top of the androgynophore; there are three styles that are united at their base, and at the top there are three stigmas. The objective of this research was to observe embryo sac development in yellow passion flowers. Ovaries at different stages of development were fixed in FAA (formalin, acetic acid and alcohol solution, hydrated, stained with Mayer’s hemalum, and dehydrated. Ovules were cleared by using methyl salicylate, mounted on slides, and observed through a confocal scanning laser microscope. The yellow passion fruit ovule is bitegmic, crassinucellate, and anatropous, and its gametophyte development is of the Polygonum type. After meiosis, functional megaspores under go three successive mitotic divisions, resulting in an eight-nucleate megagametophyte: the egg apparatus at the micropylar end, two polar nuclei at the cell center, and three antipodals at the chalazal end. The egg apparatus is formed by an egg cell and two synergids, each with a filiform apparatus. The mature embryo sac has an egg cell, two synergids, two polar nuclei, and three antipodes, as has been described for most angiosperms.

  3. Influence of Surface Segregation on Wetting of Sn-Ag-Cu (SAC) Series and Pb-Containing Solder Alloys

    Science.gov (United States)

    Bozack, M. J.; Suhling, J. C.; Zhang, Y.; Cai, Z.; Lall, P.

    2011-10-01

    Wetting of Sn-Ag-Cu (SAC) series solder alloys to solid substrates is strongly influenced by surface segregation of low-level bulk impurities in the alloys. We report in situ and real-time Auger electron spectroscopy measurements of SAC alloy surface compositions as a function of temperature as the alloys are taken through the melting point. A dramatic increase in the amount of surface C (and frequently O) is observed with temperature, and in some cases the alloy surface is nearly 80 at.% C at the melting point. The C originates from low-level impurities incorporated during alloy synthesis and inhibits wetting because C acts as a blocking layer to reaction between the alloy and substrate. A similar phenomenon has been observed over a wide range of (SAC and non-SAC) alloys synthesized by a variety of techniques. That solder alloy surfaces at melting have a radically different composition from the bulk uncovers a key variable that helps to explain the wide variability in contact angles reported in previous studies of wetting and adhesion.

  4. CHAOS-a model of the Earth's magnetic field derived from CHAMP, Orsted, and SAC-C magnetic satellite data

    DEFF Research Database (Denmark)

    Olsen, Nils; Luhr, H.; Sabaka, T.J.;

    2006-01-01

    We have derived a model of the near-Earth magnetic field (up to spherical harmonic degree n= 50 for the static field, and up to n = 18 for the first time derivative) using more than 6.5 yr of high-precision geomagnetic measurements from the three satellites Orsted, CHAMP and SAC-C taken between...

  5. sAC from aquatic organisms as a model to study the evolution of acid/base sensing.

    Science.gov (United States)

    Tresguerres, Martin

    2014-12-01

    Soluble adenylyl cyclase (sAC) is poised to play multiple physiological roles as an acid/base (A/B) sensor in aquatic organisms. Many of these roles are probably similar to those in mammals; a striking example is the evolutionary conservation of a mechanism involving sAC, carbonic anhydrase and vacuolar H⁺-ATPase that acts as a sensor system and regulator of extracellular A/B in shark gills and mammalian epididymis and kidney. Additionally, the aquatic environment presents unique A/B and physiological challenges; therefore, sACs from aquatic organisms have likely evolved distinct kinetic properties as well as distinct physiological roles. sACs from aquatic organisms offer an excellent opportunity for studying the evolution of A/B sensing at both the molecular and whole organism levels. Moreover, this information could help understand and predict organismal responses to environmental stress based on mechanistic models.This article is part of a Special Issue entitled "The Role of Soluble Adenylyl Cyclase in Health and Disease," guest edited by J. Buck and L. R. Levin.

  6. Fetus-in-fetu in the scrotal sac of a newborn infant: imaging, surgical and pathological findings

    Energy Technology Data Exchange (ETDEWEB)

    Shin, J.H.; Yoon, C.H.; Cho, K.S.; Auh, Y.H. [Department of Diagnostic Radiology, Asan Medical Center, Seoul (Korea, Republic of); Lim, S.D. [Department of Diagnostic Pathology, Asan Medical Center, Seoul (Korea, Republic of); Kim, E.A.R.; Kim, K.S.; Pi, S.Y. [Department of Pediatrics, Asan Medical Center, Seoul (Korea, Republic of); Kim, K.S. [Department of Urology, Asan Medical Center, Seoul (Korea, Republic of)

    1999-06-01

    We report a case of fetus-in-fetu located in the scrotal sac of a newborn male infant. Plain radiography (including specimen radiography), ultrasonography and MRI clearly demonstrated vertebral column, ribs, skull, pelvic bones, femurs and a portion of tibiae and humeri. The diagnosis was confirmed by pathological examination. (orig.) With 4 figs., 5 refs.

  7. What a signature adds to the consent process.

    LENUS (Irish Health Repository)

    Neary, Peter

    2012-02-03

    BACKGROUND: "Consent is a process by which a patient is informed and becomes a participant in decisions regarding their medical management." It is argued, however, that providing a signature to a form adds little to the quality of this process. METHODS: Views regarding the consent ritual of nonselected patients undergoing endoscopy (cystoscopy or sigmoidoscopy) were prospectively studied together with those of the attending staff. Patient volunteers were randomly assigned to one of two groups and given verbal explanation before the procedure, either alone (group A) or with a request to sign a form in addition (group B). A standardized questionnaire regarding preferences then was applied. RESULTS: A total of 37 patients (22 men) were studied along with seven staff members. Most surveyed felt that signing a consent form helped to empower the patient (group A, 84%; group B, 83%; staff, 100%). Although the patients mainly believed that it functioned primarily to protect the hospital and doctor (group A, 89%; group B, 67%), only one patient (3% of total) felt that such a formality undermined the patient-doctor relationship. Most staff members favored signing a form (86%). The majority of patients either favored it (group A, 47%; group B, 78%) or expressed no strong preference (group A, 32%; group B, 11%). Interestingly, more women than men preferred signing (73 vs. 55%; p = 0.25), perhaps because more women believed that it functioned to preserve autonomy (93 vs. 77% of men). Age was no particular determinant of perspective. CONCLUSION: Although it may be viewed as primarily serving to protect the doctor and hospital, the formal process of signing written consent forms appeals to patients and staff.

  8. Embedding objects during 3D printing to add new functionalities.

    Science.gov (United States)

    Yuen, Po Ki

    2016-07-01

    A novel method for integrating and embedding objects to add new functionalities during 3D printing based on fused deposition modeling (FDM) (also known as fused filament fabrication or molten polymer deposition) is presented. Unlike typical 3D printing, FDM-based 3D printing could allow objects to be integrated and embedded during 3D printing and the FDM-based 3D printed devices do not typically require any post-processing and finishing. Thus, various fluidic devices with integrated glass cover slips or polystyrene films with and without an embedded porous membrane, and optical devices with embedded Corning(®) Fibrance™ Light-Diffusing Fiber were 3D printed to demonstrate the versatility of the FDM-based 3D printing and embedding method. Fluid perfusion flow experiments with a blue colored food dye solution were used to visually confirm fluid flow and/or fluid perfusion through the embedded porous membrane in the 3D printed fluidic devices. Similar to typical 3D printed devices, FDM-based 3D printed devices are translucent at best unless post-polishing is performed and optical transparency is highly desirable in any fluidic devices; integrated glass cover slips or polystyrene films would provide a perfect optical transparent window for observation and visualization. In addition, they also provide a compatible flat smooth surface for biological or biomolecular applications. The 3D printed fluidic devices with an embedded porous membrane are applicable to biological or chemical applications such as continuous perfusion cell culture or biocatalytic synthesis but without the need for any post-device assembly and finishing. The 3D printed devices with embedded Corning(®) Fibrance™ Light-Diffusing Fiber would have applications in display, illumination, or optical applications. Furthermore, the FDM-based 3D printing and embedding method could also be utilized to print casting molds with an integrated glass bottom for polydimethylsiloxane (PDMS) device replication

  9. Cost-effective add-drop fiber optic microcell system for CDMA cellular network evolution

    Science.gov (United States)

    Cheong, Jong M.; Ham, David; Song, Myoung H.; Son, Yong S.

    2001-10-01

    In this paper, we propose a cost effective add-drop fiber-optic microcell system for CDMA cellular network. The add-drop microcell is compatible with the existing PCS or digital cellular services (DCS) systems & networks. The proposed fiber-optic add-drop access network is independent of the different channels and gives flexibility in evolution scenarios. This add-drop network provides the optimum solution to cut-down the additional rental fees by sharing the existing fiber-optic cable for cellular/PCS service providers who want to provide third generation services.

  10. Evaluation of an anal sac adenocarcinoma tumor in a Spitz dog

    Institute of Scientific and Technical Information of China (English)

    Javad; Javanbakht; Abbas; Tavassoli; Atefeh; Sabbagh; Mehdy; Aghamohammmad; Hassan; Shohreh; Alian; Samakkhah; Radmehr; Shafiee; Ali; Lakzian; Vahideh; Rahmani; Ghalee; Sonia; Shoja; Gharebagh

    2013-01-01

    A 9-year-old emasculated male Spitz with tenesmus and constipation had a subcutaneous mass at the left ventral aspect of the anus with history of polyuria and polydipsia.A complete blood cell count,serum biochemistry panel,and urinalysis(cystocentesis sample)were evaluated.Abnormalities in the serum biochemistry panel included a mildly elevated serum cholesterol concentration(7.28 mmol/L;reference interval,2.70-5.94 mmol/L),increased serum alkaline phosphatase activity(184 U/L;reference interval,9-90 U/L),alanine transaminase(122 U/L;reference interval,5-60 U/L)activity and aspartate aminotransferase(80 U/L;reference interval,5-55 U/L)activity,severe increased total calcium concentration(16.3 mg/dL;reference interval,8.2-12.4 mg/dL or 9.3-11.4 mg/dL),and decreased total calcium concentration(3.4 mg/dL,reference interval,2.5-5.6mg/dL).Furthermore,testing revealed an increased intact parathyroid hormone concentration(38.6 pmol/L;reference interval,3-17 pmol/L).On cytologic and histopathologic examinations,various types of cells were observed.Most of the cells were oval to polygonal and had elliptical or elongate nuclei and a moderate amount of pale to basophilic cytoplasm.The remaining cells had round to oval nuclei and pale to basophilic cytoplasm.Cells of both types were loosely adhered to each other and were arranged in rosette-like structures.Both neoplastic cell types had fine homogenous chromatin and either a small indistinct nucleolus or no visible nucleolus.Mild anisokaryosis and anisocytosis were observed.Histologically,the mass consists of glandular structures formed by cuboidal cells admixed with bundles of spindle cells.Based on location and histologic features,the final diagnosis was adenocarcinoma of the apocrine gland of the anal sac,which should be included as a cytologic differential diagnosis when spindle cells and typical epithelial cells are observed in masses in the region of the anal sac of dogs.

  11. Evaluation of an anal sac adenocarcinoma tumor in a Spitz dog

    Institute of Scientific and Technical Information of China (English)

    Javad Javanbakht; Abbas Tavassoli; Atefeh Sabbagh; Mehdy Aghamohammmad Hassan; Shohreh Alian Samakkhah; Radmehr Shafiee; Ali Lakzian; Vahideh Rahmani Ghalee; Sonia Shoja Gharebagh

    2013-01-01

    A 9-year-old emasculated male Spitz with tenesmus and constipation had a subcutaneous mass at the left ventral aspect of the anus with history of polyuria and polydipsia. A complete blood cell count, serum biochemistry panel, and urinalysis (cystocentesis sample) were evaluated. Abnormalities in the serum biochemistry panel included a mildly elevated serum cholesterol concentration (7.28 mmol/L; reference interval, 2.70-5.94 mmol/L), increased serum alkaline phosphatase activity (184 U/L; reference interval, 9-90 U/L), alanine transaminase (122 U/L;reference interval, 5-60 U/L) activity and aspartate aminotransferase (80 U/L; reference interval, 5-55 U/L) activity, severe increased total calcium concentration (16.3 mg/dL; reference interval, 8.2-12.4 mg/dL or 9.3-11.4 mg/dL), and decreased total calcium concentration (3.4 mg/dL, reference interval, 2.5-5.6mg/dL). Furthermore, testing revealed an increased intact parathyroid hormone concentration (38.6 pmol/L; reference interval, 3-17 pmol/L). On cytologic and histopathologic examinations, various types of cells were observed. Most of the cells were oval to polygonal and had elliptical or elongate nuclei and a moderate amount of pale to basophilic cytoplasm. The remaining cells had round to oval nuclei and pale to basophilic cytoplasm. Cells of both types were loosely adhered to each other and were arranged in rosette-like structures. Both neoplastic cell types had fine homogenous chromatin and either a small indistinct nucleolus or no visible nucleolus. Mild anisokaryosis and anisocytosis were observed. Histologically, the mass consists of glandular structures formed by cuboidal cells admixed with bundles of spindle cells. Based on location and histologic features, the final diagnosis was adenocarcinoma of the apocrine gland of the anal sac, which should be included as a cytologic differential diagnosis when spindle cells and typical epithelial cells are observed in masses in the region of the anal sac of dogs.

  12. The United States Air Force in Southeast Asia, 1961-1973: An Illustrated Account,

    Science.gov (United States)

    1984-01-01

    American people the return Maj. Edward K. Elias , USAF; Lt. Norris of the nation’s captured military men A. Charles, USN; and Lt. Markham L. was a...AFB, Col. Norbert L ................. 17 Jun 1972- Guam, assigned to 8 AF (SAC) and later Simon 30 Nov 1972 attached to Air Division Provisional, 57 Col

  13. Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors.

    Science.gov (United States)

    Takayama, Naoya; Nishikii, Hidekazu; Usui, Joichi; Tsukui, Hiroko; Sawaguchi, Akira; Hiroyama, Takashi; Eto, Koji; Nakauchi, Hiromitsu

    2008-06-01

    Human embryonic stem cells (hESCs) could potentially represent an alternative source for blood transfusion therapies and a promising tool for studying the ontogeny of hematopoiesis. When we cultured hESCs on either C3H10T1/2 or OP-9 cells to facilitate hematopoiesis, we found that exogenous administration of vascular endothelial growth factor promoted the emergence of sac-like structures, which we named embryonic stem cell-derived sacs (ES-sacs). These ES-sacs consisted of multiple cysts demarcated by cellular monolayers that retained some of the properties of endothelial cells. The spherical cells inside ES-sacs expressed primarily CD34, along with VE-cadherin, CD31, CD41a, and CD45, and were able to form hematopoietic colonies in semisolid culture and to differentiate into mature megakaryocytes by day 24 in the presence of thrombopoietin. Apparently, ES-sacs provide a suitable environment for hematopoietic progenitors. Relatively large numbers of mature megakaryocytes could be induced from the hematopoietic progenitors within ES-sacs, which were then able to release platelets that displayed integrin alpha IIb beta 3 activation and spreading in response to ADP or thrombin. This novel protocol thus provides a means of generating platelets from hESCs, which could serve as the basis for efficient production of platelets for clinical transfusion and studies of thrombopoiesis.

  14. Primary Yolk Sac Tumor of the Omentum: A Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    Kenichi Harano

    2012-12-01

    Full Text Available Yolk sac tumor (YST is a rare malignant tumor originating from germ cells. YST normally originates from the gonads, rarely occurring in extragonadal sites. We report a 35-year-old man with YST arising in the omentum, which is the first reported case of a primary YST of the omentum in an adult male. The patient presented to the community hospital with abdominal distension. A CT scan showed thickening of the omentum with ascites. The patient underwent open biopsy of the omental mass. The Pathology Department of the hospital could not make a definitive diagnosis at that time, and the tumor was considered a cancer of unknown primary (CUP origin with features of primary colorectal cancer based on the immunohistochemistry (IHC findings of the biopsy specimen (CK7–/CK20+ and CDX-2+. He was then referred to our hospital. We found that serum α-fetoprotein was abnormally elevated to 7,144 ng/ml (normal <10.0, and reevaluation of the biopsy specimen revealed microcystic or reticular patterns of tumor cells with Schiller-Duval bodies typical of YST. The present case suggests that IHC is a very useful diagnostic tool for subtyping CUP but should be interpreted in the context of clinical and morphological findings.

  15. Electrogenic transport and K(+) ion channel expression by the human endolymphatic sac epithelium.

    Science.gov (United States)

    Kim, Sung Huhn; Kim, Bo Gyung; Kim, Jin Young; Roh, Kyung Jin; Suh, Michelle J; Jung, JinSei; Moon, In Seok; Moon, Sung K; Choi, Jae Young

    2015-12-14

    The endolymphatic sac (ES) is a cystic organ that is a part of the inner ear and is connected to the cochlea and vestibule. The ES is thought to be involved in inner ear ion homeostasis and fluid volume regulation for the maintenance of hearing and balance function. Many ion channels, transporters, and exchangers have been identified in the ES luminal epithelium, mainly in animal studies, but there has been no functional study investigating ion transport using human ES tissue. We designed the first functional experiments on electrogenic transport in human ES and investigated the contribution of K(+) channels in the electrogenic transport, which has been rarely identified, even in animal studies, using electrophysiological/pharmacological and molecular biological methods. As a result, we identified functional and molecular evidence for the essential participation of K(+) channels in the electrogenic transport of human ES epithelium. The identified K(+) channels involved in the electrogenic transport were KCNN2, KCNJ14, KCNK2, and KCNK6, and the K(+) transports via those channels are thought to play an important role in the maintenance of the unique ionic milieu of the inner ear fluid.

  16. [An implantable micro-device using wireless power transmission for measuring aortic aneurysm sac pressure].

    Science.gov (United States)

    Guo, Xudong; Ge, Bin; Wang, Wenxing

    2013-08-01

    In order to detect endoleaks after endovascular aneurysm repair (EVAR), we developed an implantable micro-device based on wireless power transmission to measure aortic aneurysm sac pressure. The implantable micro-device is composed of a miniature wireless pressure sensor, an energy transmitting coil, a data recorder and a data processing platform. Power transmission without interconnecting wires is performed by a transmitting coil and a receiving coil. The coupling efficiency of wireless power transmission depends on the coupling coefficient between the transmitting coil and the receiving coil. With theoretical analysis and experimental study, we optimized the geometry of the receiving coil to increase the coupling coefficient. In order to keep efficiency balance and satisfy the maximizing conditions, we designed a closed loop power transmission circuit, including a receiving voltage feedback module based on wireless communication. The closed loop improved the stability and reliability of transmission energy. The prototype of the micro-device has been developed and the experiment has been performed. The experiments showed that the micro-device was feasible and valid. For normal operation, the distance between the transmitting coil and the receiving coil is smaller than 8cm. Besides, the distance between the micro-device and the data recorder is within 50cm.

  17. Experimental Model of Saccular Abdominal Aortic Aneurysm in Swines with Pericardium Sac

    Directory of Open Access Journals (Sweden)

    Maurício de Amorim Aquino

    2016-02-01

    Full Text Available Abstract Objective: To consider modifications in an experimental model of saccular aortic aneurysm, aiming at better reproducibility, to be used in the development of vascular prostheses. Methods: Experimental study in two phases, developed in the Center of Experimental Surgery and Bioterium (CCEB of the University of Health Sciences of Alagoas (UNCISAL, with 11 hybrid swine, female, mean weight of 20 ± 5 kg, according to modifications in the Perini technique was performed. In the first phase, the aneurysm was confectioned with bovine pericardial patch. In the second phase, fifteen days later, the patency of the aneurysms was confirmed by Doppler ultrasonography. The described variables were aortic and aneurysm sac patency, incidence of rupture, morbidity and mortality. The statistical analysis program used was STATA v.8. Results: All animals survived to the procedures. Surgical mean time was 73 minutes. Aneurysm rupture, proximal or distal aortic thrombosis, visceral or legs ischemia weren't observed. Parietal thrombus formation was observed in all of the aneurysms, two of which (18%; IC 95% = 3.98 - 48.84 were occluded and nine (82%; IC 95% = 51.15 - 96.01 were patent. Conclusion: In this series, the modifications carried out in the technique related to the surgical approach, race, anesthesia, and imaging exams reproduced the experimental model, reducing its costs, without hindering the analysis of the variables. The satisfactory patency ratio allows the method to be used in experimental models for the development of vascular prostheses.

  18. Measuring Narcissism within Add Health: The Development and Validation of a New Scale

    Science.gov (United States)

    Davis, Mark S.; Brunell, Amy B.

    2012-01-01

    This study reports the development of a measure of narcissism within the National Longitudinal Study of Adolescent Health (Add Health) data set. In Study 1, items were selected from Wave III to form the Add Health Narcissism Scale (AHNS). These were factor analyzed, yielding a single factor comprised of five subscales. We correlated the AHNS and…

  19. IMAGING DIAGNOSIS--USE OF RADIOGRAPHY AND COMPUTED TOMOGRAPHY IN THE DIAGNOSIS OF A MINERALIZED YOLK SAC IN A BROWN KIWI (APTERYX MANTELLI).

    Science.gov (United States)

    Wightman, Paul; Cohen, Eli B; Hunter, Stuart; Gartrell, Brett

    2015-01-01

    A 12-day-old Brown Kiwi (Apteryx mantelli) was presented with anorexia, torticollis, head-tilt, and coelomic distension. Radiographs showed an ill-defined, fat-opaque, coelomic mass displacing viscera craniodorsally. Curvilinear mineral opacities were superimposed over the ventral aspect of the mass. Computed tomography demonstrated the presence of mineral within the periphery of a fat attenuating mass consistent with a retained yolk sac. A deutectomy (yolk sac excision) was performed. Histopathology of the excised tissue confirmed the diagnosis of a retained yolk sac with multifocal mineralization.

  20. Primary Diffuse Large B-Cell Lymphoma Localized to the Lacrimal Sac: A Case Presentation and Review of the Literature.

    Science.gov (United States)

    Zarrabi, Kevin; Desai, Ved; Yim, Brandom; Gabig, Theodore G

    2016-01-01

    We report a rare case of diffuse large B-cell lymphoma (DLBCL) of the lacrimal sac in a 50-year-old male. The incidence of primary ocular lymphoma is low and it is considered a rare disease. Moreover, reports of ocular DLBCL are uncommon and the disease remains poorly characterized. Our patient presented for management of osteomyelitis and was incidentally found to have a painless swelling and cyst around his right eye. A PET/CT scan revealed hypermetabolic activity within the lacrimal sac and a subsequent excisional biopsy of the mass yielded histopathology consistent with DLBCL. Consequently, the patient underwent treatment with R-CHOP therapy. The patient responded well to chemotherapy with a substantial shrinkage in tumor burden and the disease remained localized. Herein, we present a rare case of primary ocular lymphoma, highlight the importance of early diagnosis, and review current treatment modalities.

  1. Primary Diffuse Large B-Cell Lymphoma Localized to the Lacrimal Sac: A Case Presentation and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Kevin Zarrabi

    2016-01-01

    Full Text Available We report a rare case of diffuse large B-cell lymphoma (DLBCL of the lacrimal sac in a 50-year-old male. The incidence of primary ocular lymphoma is low and it is considered a rare disease. Moreover, reports of ocular DLBCL are uncommon and the disease remains poorly characterized. Our patient presented for management of osteomyelitis and was incidentally found to have a painless swelling and cyst around his right eye. A PET/CT scan revealed hypermetabolic activity within the lacrimal sac and a subsequent excisional biopsy of the mass yielded histopathology consistent with DLBCL. Consequently, the patient underwent treatment with R-CHOP therapy. The patient responded well to chemotherapy with a substantial shrinkage in tumor burden and the disease remained localized. Herein, we present a rare case of primary ocular lymphoma, highlight the importance of early diagnosis, and review current treatment modalities.

  2. A global model of mantle conductivity derived from 5 years of CHAMP, Orsted, and SAC-C magnetic data

    DEFF Research Database (Denmark)

    Kuvshinov, A.; Olsen, Nils

    2006-01-01

    We present a global 1-D conductivity model which is obtained by analysis of five years ( 2001 - 2005) of simultaneous magnetic data from the three satellites Orsted, CHAMP and SAC-C. After removal of core and crustal fields as predicted by a recent field model we used non-polar scalar and vector...... model which is rather similar to models derived from ground-based data....

  3. Archaeological Survey and Site Testing in Sloughing Easement Areas along the Sac River Downstream from Stockton Dam, Missouri.

    Science.gov (United States)

    1986-01-01

    lower Pomme de Terre River Valley by McMillan (1976a). Post oak, white oak, and black oak were found to be the most abundant tree species; but...lists for the lower Pomme de Terre River Valley along with the habitat preferences of each species. Similar species were probably present in the...research has been carried out in the lover Sac River drainage, the Pomme de Terre River drainage, and the Osage River drainage. Most of this work

  4. Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity.

    Science.gov (United States)

    Frame, Jenna M; Fegan, Katherine H; Conway, Simon J; McGrath, Kathleen E; Palis, James

    2016-02-01

    Adult-repopulating hematopoietic stem cells (HSCs) emerge in low numbers in the midgestation mouse embryo from a subset of arterial endothelium, through an endothelial-to-hematopoietic transition. HSC-producing arterial hemogenic endothelium relies on the establishment of embryonic blood flow and arterial identity, and requires β-catenin signaling. Specified prior to and during the formation of these initial HSCs are thousands of yolk sac-derived erythro-myeloid progenitors (EMPs). EMPs ensure embryonic survival prior to the establishment of a permanent hematopoietic system, and provide subsets of long-lived tissue macrophages. While an endothelial origin for these HSC-independent definitive progenitors is also accepted, the spatial location and temporal output of yolk sac hemogenic endothelium over developmental time remain undefined. We performed a spatiotemporal analysis of EMP emergence, and document the morphological steps of the endothelial-to-hematopoietic transition. Emergence of rounded EMPs from polygonal clusters of Kit(+) cells initiates prior to the establishment of arborized arterial and venous vasculature in the yolk sac. Interestingly, Kit(+) polygonal clusters are detected in both arterial and venous vessels after remodeling. To determine whether there are similar mechanisms regulating the specification of EMPs with other angiogenic signals regulating adult-repopulating HSCs, we investigated the role of embryonic blood flow and Wnt/β-catenin signaling during EMP emergence. In embryos lacking a functional circulation, rounded Kit(+) EMPs still fully emerge from unremodeled yolk sac vasculature. In contrast, canonical Wnt signaling appears to be a common mechanism regulating hematopoietic emergence from hemogenic endothelium. These data illustrate the heterogeneity in hematopoietic output and spatiotemporal regulation of primary embryonic hemogenic endothelium.

  5. Low-lying π∗ resonances associated with cyano groups: A CAP/SAC-CI study

    Science.gov (United States)

    Ehara, Masahiro; Kanazawa, Yuki; Sommerfeld, Thomas

    2017-01-01

    The complex absorbing potential (CAP)/symmetry-adapted cluster-configuration interaction (SAC-CI) method is applied to low-lying π∗ resonance states of molecules containing one or two cyano (CN) groups. Benchmark calculations are carried out comparing the non-variational and approximate variational approach of SAC-CI and studying the selection threshold of operators. Experimental resonance positions from electron transmission spectroscopy (ETS) are reproduced provided the anticipated deviations due to vibronic effects are taken into account. Moreover, the calculated positions and widths agree well with those obtained in previous electron scattering calculations for HCN, CH3CN and their isonitriles. Based on our results, we suggest a reassignment of the experimental ETS of fumaronitrile and malononitrile. Our present results demonstrate again that the CAP/SAC-CI method reliably predicts low-lying π∗ resonances, and regarding the total numbers of molecules and resonances investigated, it is fair to say that it is presently the most extensively used high-level method in the temporary anion field.

  6. Intracranial yolk sac tumor in an adult patient: MRI, diffusion-weighted imaging and 1H MR spectroscopy features

    Directory of Open Access Journals (Sweden)

    Mačvanski Marija

    2012-01-01

    Full Text Available Introduction. Yolk sac tumors represent only 5%-7% of intracranial germ cell tumors, which comprise about 1% of all primary brain tumors in adults. Literature data about nonspecific imaging characteristics of these tumors are scant. We presented magnetic resonance imaging findings with diffusion-weighted imaging and proton magnetic resonance spectroscopy of this rare type of tumor in an adult patient. Case report. A 55-year-old man with progressive left side weakness, headache, dizziness and ataxia, underwent preoperative magnetic resonance imaging, diffusion-weighted imaging and proton magnetic resonance spectroscopy. After surgical resection and histological analysis, the final diagnosis of yolk sac tumor was established. Retrospective imaging analysis were performed in order to determine imaging and biochemical parameters that could be useful in the diagnostic evaluation of this tumor type. Conclusion. Though the imaging features of yolk sac tumor are not specific, morphoanatomical and metabolic imaging could offer the information that provides new insights into this tumor that may facilitate further therapeutic decision process and potentially provides better information regarding the disease prognosis.

  7. Radio Telescopes Will Add to Cassini-Huygens Discoveries

    Science.gov (United States)

    2004-12-01

    When the European Space Agency's Huygens spacecraft makes its plunge into the atmosphere of Saturn's moon Titan on January 14, radio telescopes of the National Science Foundation's National Radio Astronomy Observatory (NRAO) will help international teams of scientists extract the maximum possible amount of irreplaceable information from an experiment unique in human history. Huygens is the 700-pound probe that has accompanied the larger Cassini spacecraft on a mission to thoroughly explore Saturn, its rings and its numerous moons. The Green Bank Telescope The Robert C. Byrd Green Bank Telescope CREDIT: NRAO/AUI/NSF (Click on image for GBT gallery) The Robert C. Byrd Green Bank Telescope (GBT) in West Virginia and eight of the ten telescopes of the continent-wide Very Long Baseline Array (VLBA), located at Pie Town and Los Alamos, NM, Fort Davis, TX, North Liberty, IA, Kitt Peak, AZ, Brewster, WA, Owens Valley, CA, and Mauna Kea, HI, will directly receive the faint signal from Huygens during its descent. Along with other radio telescopes in Australia, Japan, and China, the NRAO facilities will add significantly to the information about Titan and its atmosphere that will be gained from the Huygens mission. A European-led team will use the radio telescopes to make extremely precise measurements of the probe's position during its descent, while a U.S.-led team will concentrate on gathering measurements of the probe's descent speed and the direction of its motion. The radio-telescope measurements will provide data vital to gaining a full understanding of the winds that Huygens encounters in Titan's atmosphere. Currently, scientists know little about Titan's winds. Data from the Voyager I spacecraft's 1980 flyby indicated that east-west winds may reach 225 mph or more. North-south winds and possible vertical winds, while probably much weaker, may still be significant. There are competing theoretical models of Titan's winds, and the overall picture is best summarized as

  8. 基于 Python 语言的 Add -In 开发应用%The Development and Application of Add-In Based on Python Language

    Institute of Scientific and Technical Information of China (English)

    张玉群; 朱道壮

    2014-01-01

    By introducing the process method of Python language menu developmentusing Add-In plugins in ArcGIS, proposed in ArcGIS for data processing, to guide developers to use a simple way of development.%通过简要介绍Python语言在ArcGIS中采用Add-In插件进行菜单开发的流程,提出了在ArcGIS进行数据处理时,开发人员应使用的一种简便易行的开发方式。

  9. Rat visceral yolk sac cells: viability and expression of cell markers during maternal diabetes

    Energy Technology Data Exchange (ETDEWEB)

    Aires, M.B. [Departamento de Morfologia, Universidade Federal de Sergipe, São Cristóvão, SE (Brazil); Santos, J.R.A. [Departamento de Enfermagem, Universidade Federal de Sergipe, São Cristóvão, SE (Brazil); Souza, K.S.; Farias, P.S. [Departamento de Morfologia, Universidade Federal de Sergipe, São Cristóvão, SE (Brazil); Santos, A.C.V. [Departamento de Enfermagem, Universidade Federal de Sergipe, São Cristóvão, SE (Brazil); Fioretto, E.T. [Departamento de Morfologia, Universidade Federal de Sergipe, São Cristóvão, SE (Brazil); Maria, D.A. [Laboratório de Bioquímica e Biofísica, Instituto Butantan, São Paulo, SP (Brazil)

    2015-07-10

    The function of the visceral yolk sac (VYS) is critical for embryo organogenesis until final fetal development in rats, and can be affected by conditions such as diabetes. In view of the importance of diabetes during pregnancy for maternal and neonatal health, the objective of this study was to assess fetal weight, VYS cell markers, and viability in female Wistar rats (200-250 g) with induced diabetes (alloxan, 37 mg/kg) on the 8th gestational day (gd 8). At gd 15, rats from control (n=5) and diabetic (n=5) groups were anesthetized and laparotomized to remove the uterine horns for weighing of fetuses and collecting the VYS. Flow cytometry was used for characterizing VYS cells, and for determining mitochondrial activity, cell proliferation, DNA ploidy, cell cycle phases, and caspase-3 activity. Fetal weight was reduced in the diabetic group. Expression of the cell markers CD34, VEGFR1, CD115, CD117, CD14, CCR2, CD90, CD44, STRO-1, OCT3/4, and Nanog was detected in VYS cells in both groups. In the diabetic group, significantly decreased expression of CD34 (P<0.05), CCR2 (P<0.001), and OCT3/4 (P<0.01), and significantly increased expression of CD90 (P<0.05), CD117 (P<0.01), and CD14 (P<0.05) were observed. VYS cells with inactive mitochondria, activated caspase-3, and low proliferation were present in the rats with diabetes. Severe hyperglycemia caused by maternal diabetes had negative effects on pregnancy, VYS cell viability, and the expression of cell markers.

  10. Automatic segmentation and measurements of gestational sac using static B-mode ultrasound images

    Science.gov (United States)

    Ibrahim, Dheyaa Ahmed; Al-Assam, Hisham; Du, Hongbo; Farren, Jessica; Al-karawi, Dhurgham; Bourne, Tom; Jassim, Sabah

    2016-05-01

    Ultrasound imagery has been widely used for medical diagnoses. Ultrasound scanning is safe and non-invasive, and hence used throughout pregnancy for monitoring growth. In the first trimester, an important measurement is that of the Gestation Sac (GS). The task of measuring the GS size from an ultrasound image is done manually by a Gynecologist. This paper presents a new approach to automatically segment a GS from a static B-mode image by exploiting its geometric features for early identification of miscarriage cases. To accurately locate the GS in the image, the proposed solution uses wavelet transform to suppress the speckle noise by eliminating the high-frequency sub-bands and prepare an enhanced image. This is followed by a segmentation step that isolates the GS through the several stages. First, the mean value is used as a threshold to binarise the image, followed by filtering unwanted objects based on their circularity, size and mean of greyscale. The mean value of each object is then used to further select candidate objects. A Region Growing technique is applied as a post-processing to finally identify the GS. We evaluated the effectiveness of the proposed solution by firstly comparing the automatic size measurements of the segmented GS against the manual measurements, and then integrating the proposed segmentation solution into a classification framework for identifying miscarriage cases and pregnancy of unknown viability (PUV). Both test results demonstrate that the proposed method is effective in segmentation the GS and classifying the outcomes with high level accuracy (sensitivity (miscarriage) of 100% and specificity (PUV) of 99.87%).

  11. Imaging and clinical findings in large endolymphatic duct and sac syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Koesling, Sabrina [University of Halle, Department of Radiology, E-Grube-Street 40, D-06097 Halle (Germany)]. E-mail: sabrina.koesling@medizin.uni-halle.de; Rasinski, Christine [University of Halle, Department of Otorhinolaryngology (Germany); Amaya, Beatrice [University of Halle, Department of Radiology, E-Grube-Street 40, D-06097 Halle (Germany)

    2006-01-15

    Objective: Large endolymphatic duct and sac syndrome (LEDS) is known as the most common kind of inner ear malformations, which is radiologically detectable. Nevertheless, nowadays many questions are not fully cleared and LEDS is relatively unknown among general radiologists. The aim of this study was to evaluate the incidence of LEDS in the own patient population and to present our experiences regarding imaging findings, clinical presentation and follow up. Materials and methods: Based on a complete recording of all patients, sent from ENT department to radiology, we identified all radiological diagnosed cases of inner ear malformations including LEDS and all patients in whom an inner ear malformation was clinically suspected. The retrospective study included clinical records, HR-CT and MRI performed between 1994 and 2002. Results: Among 169 patients (338 ear), 17 of patients (median age: 12 years) and 28 ears, respectively, had enlarged endolymphatic structures. In 10 patients - 6% - (15 ears), no other abnormalities were detected, called isolated LEDS, seven patients showed additional inner ear abnormalities. One patient showed a labyrinthine hemorrhage after sudden hearing loss. Audiometric data revealed sensorineural hearing loss in 22 ears, deafness in 5 ears and normal hearing in 1 case of 28 ears. In 10 (67%) of 15 ears with isolated LEDS, the hearing loss was downward-fluctuating progressive. Twelve patients (eight with isolated LEDS) had partly repeated sudden hearing losses. A trigger for worsening of hearing was found in five patients. A correlation between the severity of morphological changes on imaging and the degree of hearing disturbances could not be detected. Only four young patients underwent a radiological examination within the first or second year after onset of hearing loss. Three patients received a cochlear implant. Conclusions: LEDS might be the cause of progressive hearing loss and repeated acute hearing losses in children and young

  12. Enhanced Permeability of Etoposide across Everted Sacs of Rat Small Intestine by Vitamin E-TPGS.

    Science.gov (United States)

    Parsa, Abdolhamid; Saadati, Roonak; Abbasian, Zahra; Azad Aramaki, Saeed; Dadashzadeh, Simin

    2013-01-01

    Etoposide, a widely used anticancer drug, exhibits low and variable oral bioavailability mainly because of being substrate for the efflux transporter, P-glycoprotein (P-gp). Therefore, the present study was aimed to investigate the effect of D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) and PEG 400 as P-gp inhibitors on the intestinal absorption of etoposide. Everted sacs of rat small intestine were incubated in Krebs buffer solution which contained etoposide in the absence or presence of various concentrations of TPGS or PEG 400. The effect of verapamil as a known P-gp inhibitor on the absorption of drug was also studied. The absorptive transport of etoposide was significantly enhanced (p < 0.001) in the presence of verapamil (100 μg/mL) and TPGS (over the concentration range of 0.002- 0.1 mg/mL), suggesting that the inhibition of P-gp located in the intestine may be involved in the enhancement of etoposide absorption. However, the addition of PEG 400 at various concentrations (0.05, 0.1 and 0.5% w/v) had no effect on the etoposide transport. No significant difference was found between the permeability values in the absence and presence of the maximum concentration of TPGS for two transport markers, lucifer yellow and imipramine, indicating that the enhancement in etoposide permeability in the presence of TPGS was not due to the compromise in tight junctions or membrane integrity of epithelial cells. The results of the study suggest that the use of TPGS as a safe excipient in etoposide formulations may enhance the oral bioavailability of etoposide and result in a predictable oral absorption.

  13. In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis.

    Science.gov (United States)

    Vanhee, Stijn; De Mulder, Katrien; Van Caeneghem, Yasmine; Verstichel, Greet; Van Roy, Nadine; Menten, Björn; Velghe, Imke; Philippé, Jan; De Bleser, Dominique; Lambrecht, Bart N; Taghon, Tom; Leclercq, Georges; Kerre, Tessa; Vandekerckhove, Bart

    2015-02-01

    Although hematopoietic precursor activity can be generated in vitro from human embryonic stem cells, there is no solid evidence for the appearance of multipotent, self-renewing and transplantable hematopoietic stem cells. This could be due to short half-life of hematopoietic stem cells in culture or, alternatively, human embryonic stem cell-initiated hematopoiesis may be hematopoietic stem cell-independent, similar to yolk sac hematopoiesis, generating multipotent progenitors with limited expansion capacity. Since a MYB was reported to be an excellent marker for hematopoietic stem cell-dependent hematopoiesis, we generated a MYB-eGFP reporter human embryonic stem cell line to study formation of hematopoietic progenitor cells in vitro. We found CD34(+) hemogenic endothelial cells rounding up and developing into CD43(+) hematopoietic cells without expression of MYB-eGFP. MYB-eGFP(+) cells appeared relatively late in embryoid body cultures as CD34(+)CD43(+)CD45(-/lo) cells. These MYB-eGFP(+) cells were CD33 positive, proliferated in IL-3 containing media and hematopoietic differentiation was restricted to the granulocytic lineage. In agreement with data obtained on murine Myb(-/-) embryonic stem cells, bright eGFP expression was observed in a subpopulation of cells, during directed myeloid differentiation, which again belonged to the granulocytic lineage. In contrast, CD14(+) macrophage cells were consistently eGFP(-) and were derived from eGFP-precursors only. In summary, no evidence was obtained for in vitro generation of MYB(+) hematopoietic stem cells during embryoid body cultures. The observed MYB expression appeared late in culture and was confined to the granulocytic lineage.

  14. Air Consumption Analysis of Air-Jet Weaving

    Directory of Open Access Journals (Sweden)

    RAJ KUMAR KHIANI

    2016-07-01

    Full Text Available In Textile industry, production is mostly key concern for Industry owner. This always has attracted researchers and machines manufacturers to make new developments in process and machines. Air-jet is one of the leading and successful highest productive weaving machines. However, it is now well established that due to add of charges of compressed air, manufacturing cost of air-jet weaving machine is higher as compared with rapier and projectile weaving machines. This is why countries having energy issues do not prefer air-jet weaving machines comparing projectile weaving machines. In this regard, several researchers and machine manufacturers have continuously been working to improve the efficiency of air-jet weft insertion. However, industry practice is as important as design made by researchers. The aim of this research is to investigate the air consumption of air-jet weaving on industrial scale practice. In this study, five weaving machine of same manufacturer and model were selected. It was observed that despite of manufacturing same quality of fabric, air consumption was varying almost in all weaving machines. Conventionally, mill workers adopt hit and trial practice in weaving industry including airpressure setting which leads to variation of nozzle pressure. Main reason of disparity of air consumption in air-jet weaving machines may be variation of distance from compressor to weaving machines, number of joints, un-necessary valve opening and pipes leakages cause an increase of compressed air consumption.

  15. Tunable add-drop filter using an active whispering gallery mode microcavity

    CERN Document Server

    Monifi, Faraz; Yang, Lan

    2013-01-01

    An add-drop filter (ADF) fabricated using a whispering gallery mode resonator has different crosstalks for add and drop functions due to non-zero intrinsic losses of the resonator. Here, we show that introducing gain medium in the resonator and optically pumping it below the lasing threshold not only allows loss compensation to achieve similar and lower crosstalks but also tunability in bandwidth and add-drop efficiency. For an active ADF fabricated using an erbium-ytterbium co-doped microsphere, we achieved 24-fold enhancement in the intrinsic quality factor, 3.5-fold increase in drop efficiency, bandwidth tunability of 35 MHz and a crosstalk of only 2%.

  16. ADD1/SREBP1c activates the PGC1-alpha promoter in brown adipocytes

    DEFF Research Database (Denmark)

    Hao, Qin; Hansen, Jacob B; Petersen, Rasmus K

    2010-01-01

    regulatory element-binding protein-1c (SREBP1c) and peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC1alpha) in brown and inguinal white adipose tissues, but not in epididymal white adipose tissue. Using in vitro models of white and brown adipocytes we demonstrate that beta......-adrenergic stimulation induced expression of LXRalpha, ADD1/SREBP1c and PGC1alpha in cells with a brown-like adipose phenotype. We demonstrate that ADD1/SREBP1c is a powerful inducer of PGC1alpha expression via a conserved E box in the proximal promoter and that beta-adrenergic stimulation led to recruitment of ADD1...

  17. Consumer Mental Accounts and Implications to Selling Base Products and Add-ons

    OpenAIRE

    Sanjiv Erat; Sreekumar R. Bhaskaran

    2012-01-01

    Firms in a variety of industries offer add-on products to consumers who have previously purchased a base product. We posit that consumers, in making their decisions as to whether to purchase add-ons that complement the base products, find a greater need for the value offered by the add-ons when the "unrecovered" value (i.e., price paid minus the benefits obtained so far) associated with the base products is higher. We conduct experiments that test the proposed hypothesis and examine the strat...

  18. Experimental studies of a matrix-tubular solar air collector

    Energy Technology Data Exchange (ETDEWEB)

    Plesca, M.; Varlan, P. [Moldova Technical Univ., Chisinau (Moldova, Republic of). Dept. of Heat and Gas Supply and Ventilation

    2009-06-15

    The most common types of solar air collectors (SAC) are contact-type and matrix-type collectors, with the latter being more efficient. This paper described the design and testing of a matrix-tubular flat solar air collector in the city of Chisinau, Moldova, where the outdoor climatic radiation, heat, and humidity characteristics are favorable for the efficient use of solar energy for building heating and drying applications. The amount of solar energy absorbed by a solar energy air collector depends on the level of insulation and orientation of the solar collector; the absorbance of the absorber surface; and the transmittance of the cover material. This study examined the heat transfer, efficiency, and pressure drop using copper tubes inserted perpendicular to the plane of the absorber plate. The SAC consists of a glazed insulated case, an absorber, and ducting for cold air delivery and hot air discharge. Copper tubes are inserted perpendicular to the plane of the absorber. The absorber is installed in the body of the SAC in such a way that it divides it into an upper channel and lower channel. The channel bottom is lined with aluminium foil that reflects solar radiation coming through the tubes and decreases heat loss in the solar collector. Copper tubes increase the heat exchange surface, create air turbulence and intensify heat transfer. This increases the efficiency of the solar collector. The pressure drop of the matrix-tubular solar air collector is 40 per cent lower than that of the matrix-plate collectors. 11 refs., 2 tabs., 6 figs.

  19. Mothers whose children have ADD/ADHD discuss their children's medication use: an investigation of blogs.

    Science.gov (United States)

    Clarke, Juanne N; Lang, Laura

    2012-01-01

    This article presents the results of a frame and discourse analysis of Internet blog sites where parents (usually mothers) discuss their concerns about medication use by their children with attention deficit disorder or attention deficit hyperactivity disorder (ADD/ADHD). This is a particularly important topic in an era characterized by powerful circulating discourses around the contentious medicalization of, and prevalent pharmaceutical treatments for, ADD/ADHD, as well as the mother blame associated with having a child diagnosed with ADD/ADHD. The findings document that the mothers see ADD/ADHD as legitimate medical diagnoses and view themselves as caretakers of children with brain and neuro-chemical anomalies affecting the behavior of their children. They favor pharmaceutical use and describe themselves as experts in the difficult and complex issues related to pharmaceuticalized parenting. At the same time their adoption of medicalization is contingent as they express specific critiques of some doctors, some types of doctors, and critically evaluate science.

  20. Design of a Floating-Point Fused Add-Subtract Unit Using Verilog

    Directory of Open Access Journals (Sweden)

    Mayank Sharma,

    2013-06-01

    Full Text Available A floating-point (FP fused add-subtract unit is presented that performs simultaneous floating-point operation of add-subtract on a common pair of single-precision data at the same time that it takes to perform in a single addition with a conventional floating-point adder. The system was placed and routed in 45nm process so that there will be less consumption of memory as well as power.

  1. Prenatal ultrasonic diagnosis of fetal lacrimal sac cyst%产前超声诊断胎儿泪囊囊肿

    Institute of Scientific and Technical Information of China (English)

    黄苑铭; 黄冬平; 梁耀佳; 邹鹏; 陈丹; 马小燕

    2012-01-01

    目的 探讨产前超声诊断胎儿泪囊囊肿的价值.方法 回顾性分析12胎产前超声诊断为胎儿泪囊囊肿的声像图特征,并追踪其妊娠结局.结果 产前超声检出12胎胎儿泪囊囊肿,孕周为26~36周,其中双侧3胎,单侧9胎.泪囊囊肿典型超声声像图表现为眼眶内下方见囊性无回声.6胎囊肿产前自行消失;1胎经终止妊娠后确定存在泪囊囊肿2胎分娩后囊肿自行消失;1胎分娩后因新生儿呼吸窘迫而接受外科手术治疗;2胎失访.结论 胎儿泪囊囊肿有其特征性超声表现,正确诊断有利于指导临床工作.%To explore the value of prenatal ultrasound in diagnosis of lacrimal sac cyst. Methods Prenatal ultrasonic features of 12 fetuses with fetal lacrimal sac cyst were retrospectively analyzed, and the pregnancy outcomes were followed up. Results Twelve fetuses of fetal lacrimal sac cyst were detected with prenatal ultrasound, and their gestational age ranged from 26 to 36 weeks. Among these fetuses, lacrimal sac cyst was bilateral in 3 fetuses and unilateral in 9 fetuses. The typical ultrasonic feature of lacrimal sac cyst was cystic mass without echo in medial and inferior orbit. The lacrimal sac cyst resolved spontaneously prenatally in 6 fetuses. One lacrimal sac cyst was determined after termination of pregnancy. Two lacrimal sac cyst resolved spontaneously after delivery. The lacrimal sac cyst disappeared in one newborn after receiving surgical intervention for respiratory distress syndrome after delivery. Two fetuses were lost during follow-up. Conclusion Fetal lacrimal sac cyst has characteristic ultrasonic appearances. Correct diagnosis is valuable for guiding clinical work.

  2. Air Pollution

    Science.gov (United States)

    Air pollution is a mixture of solid particles and gases in the air. Car emissions, chemicals from factories, dust, ... a gas, is a major part of air pollution in cities. When ozone forms air pollution, it's ...

  3. Evidence of the most stretchable egg sac silk stalk, of the European spider of the year Meta menardi.

    Directory of Open Access Journals (Sweden)

    Emiliano Lepore

    Full Text Available Spider silks display generally strong mechanical properties, even if differences between species and within the same species can be observed. While many different types of silks have been tested, the mechanical properties of stalks of silk taken from the egg sac of the cave spider Meta menardi have not yet been analyzed. Meta menardi has recently been chosen as the "European spider of the year 2012", from the European Society of Arachnology. Here we report a study where silk stalks were collected directly from several caves in the north-west of Italy. Field emission scanning electron microscope (FESEM images showed that stalks are made up of a large number of threads, each of them with diameter of 6.03 ± 0.58 µm. The stalks were strained at the constant rate of 2 mm/min, using a tensile testing machine. The observed maximum stress, strain and toughness modulus, defined as the area under the stress-strain curve, are 0.64 GPa, 751% and 130.7 MJ/m(3, respectively. To the best of our knowledge, such an observed huge elongation has never been reported for egg sac silk stalks and suggests a huge unrolling microscopic mechanism of the macroscopic stalk that, as a continuation of the protective egg sac, is expected to be composed by fibres very densely and randomly packed. The Weibull statistics was used to analyze the results from mechanical testing, and an average value of Weibull modulus (m is deduced to be in the range of 1.5-1.8 with a Weibull scale parameter (σ(0 in the range of 0.33-0.41 GPa, showing a high coefficient of correlation (R(2 = 0.97.

  4. Effects of post-reflow cooling rate and thermal aging on growth behavior of interfacial intermetallic compound between SAC305 solder and Cu substrate

    Science.gov (United States)

    Hu, Xiaowu; Xu, Tao; Jiang, Xiongxin; Li, Yulong; Liu, Yi; Min, Zhixian

    2016-04-01

    The interfacial reactions between Cu and Sn3Ag0.5Cu (SAC305) solder reflowed under various cooling rates were investigated. It is found that the cooling rate is an important parameter in solder reflow process because it influences not only microstructure of solder alloy but also the morphology and growth of intermetallic compounds (IMCs) formed between solder and Cu substrate. The experimental results indicate that only scallop-like Cu6Sn5 IMC layer is observed between solder and Cu substrate in case of water cooling and air cooling, while bilayer composed of scallop-like Cu6Sn5 and thin layer-like Cu3Sn is detected under furnace cooling due to sufficient reaction time to form Cu3Sn between Cu6Sn5 IMC and Cu substrate which resulted from slow cooling rate. Samples with different reflow cooling rates were further thermal-aged at 423 K. And it is found that the thickness of IMC increases linearly with square root of aging time. The growth constants of interfacial IMC layer during aging were obtained and compared for different cooling rates, indicating that the IMC layer thickness increased faster in samples under low cooling rate than in the high cooling rate under the same aging condition. The long prismatic grains were formed on the existing interfacial Cu6Sn5 grains to extrude deeply into solder matrix with lower cooling rate and long-term aging, and the Cu6Sn5 grains coarsened linearly with cubic root of aging time.

  5. Clima organizacional y satisfacción laboral en la empresa f y d inversiones S.A.C.

    OpenAIRE

    Hospinal Escajadillo, Sandro; Universidad Nacional Mayor de San Marcos, Facultad de Ingeniería Industrial. Lima, Perú

    2016-01-01

    El artículo trata sobre un trabajo de investigación para determinar, i) el nivel actual de clima organizacional y satisfacción laboral, ii) la relación que existe entre ambas variables y ii) los principales factores críticos que afectan a cada una de ellas, en la empresa F y D Inversiones S.A.C. The article discusses a research project to determine i) the current level of organizational climate and job satisfaction, ii) the relationship between the two variables and ii) the main critical f...

  6. Redox activity of melanin from the ink sac of Sepia officinalis by means of colorimetric oxidative assay.

    Science.gov (United States)

    Srisuk, Pathomthat; Correlo, Vitor M; Leonor, Isabel B; Palladino, Pasquale; Reis, Rui L

    2016-01-01

    The redox properties of natural extract from cuttlefish ink sac (Sepia officinalis) and synthetic melanin used as a biomimetic in melanin structural investigation were determined by comparison of this phenol-based heterogeneous pigment with gallic acid used as a standard in Folin-Ciocalteu colorimetric assay widely employed for characterisation of oxidative properties of biomaterials. Reactivity of sepia melanin reported here is much higher than previously indicated and this protocol should allow the redox characterisation of all melanins irrespective of their origin and composition.

  7. Cloning and expression of vacuolar proton-pumping ATPase subunits in the follicular epithelium of the bullfrog endolymphatic sac

    OpenAIRE

    Yajima, Shinya; Kubota, Makoto; Nakakura, Takashi; Hasegawa, Takahiro; Katagiri, Nobuto; Tomura, Hideaki; Sasayama, Yuichi; Suzuki, Masakazu; Tanaka, Shigeyasu

    2007-01-01

    In an investigation aimed at clarifying the mechanism of crystal dissolution of the calcium carbonate lattice in otoconia (the mineral particles embedded in the otolithic membrane) of the endolymphatic sac (ELS) of the bullfrog, cDNAs encoding the A- and E-subunits of bullfrog vacuolar proton-pumping ATPase (V-ATPase) were cloned and sequenced. The cDNA of the A-subunit consisted of an 11-bp 5′-untranslated region (UTR), a 1,854-bp open reading frame (ORF) encoding a protein comprising 617 am...

  8. Sistema de tratamiento integral de aguas residuales industriales en UEA Animón de Empresa Administradora Chungar SAC

    OpenAIRE

    Requena Mendizabal, Manuel Andrés

    2008-01-01

    Empresa Administradora Chungar S.A.C. (EACH) desarrolla sus operaciones en la Mina Animón y explota un yacimiento mineral de tipo vetiforme, ubicado por debajo y en dirección transversal a la laguna Naticocha Centro y otras lagunas del entorno. Debido a la cercanía de estos cuerpos de agua es necesario tener vertimientos industriales de óptima calidad a fin de preservar estos recursos hídricos, cumpliendo así con la Ley General de Aguas D.L 17752. Con este motivo ha sido necesario elabora...

  9. CT Findings of Intrarenal Yolk Sac Tumor with Tumor Thrombus Extending into the Inferior Vena Cava: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Shao Chun; Li, Xue Hua; Sun, Can Hui; Feng, Shi Ting; Peng, Zhen Peng; Huang, Si Yun; Li, Zi Ping [Dept. of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou (China)

    2014-10-15

    Yolk sac tumor (YST) is a rare germ cell neoplasm of childhood that usually arises from the testis or ovary. The rare cases of YST in various extragonadal locations have been reported, but the primary intrarenal YST is even more uncommon. Here, we report a case of a primary intrarenal YST with tumor thrombus of the inferior vena cava and left renal vein in a 2-year-old boy, with an emphasis on the CT features. To our knowledge, this is the first reported case of an intrarenal YST with intravascular involvement.

  10. Physical mapping of BK virus DNA with SacI, MboII, and AluI restriction endonucleases.

    Science.gov (United States)

    Yang, R C; Wu, R

    1978-12-01

    A new restriction endonuclease, SacI from Streptomyces achromogenes cleaves BK virus (strain MM) DNA into 3 fragments, whereas MboII from Moraxella bovis and AluI from Arthrobacter luteus give 22 and 30 fragments, respectively. All these specific DNA fragments were ordered and mapped on the viral genome by two methods first, by the reciprocal digestion method using uniformly 32P-labeled DNA; and second, by the partial digestion technique using the single-end 32P-labeled DNA. This study, together with those reported earlier, defined the location of 90 cleavage sites on the BK virus DNA.

  11. Introduction to IEC TC115 3rd Plenary Meeting and the Recent Work of SAC/TC324%IEC TC115第3次全会和SAC/TC324工作近况

    Institute of Scientific and Technical Information of China (English)

    舒印彪; 刘泽洪; 范建斌; 于永清

    2011-01-01

    为了及时掌握高压直流输电技术的国际标准化动态并明确未来几年的工作方向,详细描述了2011年11月在德国柏林召开的国际电工委员会(IEC)第115技术委员会(TC115)第3次全会的情况,概述了IEC TC115各工作组和项目组近期的工作动态。最后,介绍了全国高压直流输电工程标准化技术委员会(SAC/TC324)近期的工作进展情况。%In order to master the latest trend of the international standardization in HVDC transmission field and make clear the direction of the work in the coming years,we detailed the 3rd plenary meeting of International Electrotechnical Committee(IEC) 115th Technical Committee(TC115) held in Berlin,Germany in Nov.,2011,and overviewed IEC TC115 WG1,WG2,WG3 and PT1 meetings.Moreover,the recent work of the Standardization Technical Committee for HVDC power transmission project(SAC/TC324) in China was described.

  12. A clinicopathological analysis of papillary endolymphatic sac tumor in inner ear

    Directory of Open Access Journals (Sweden)

    LIN Yu-jing

    2013-05-01

    Full Text Available Background Endolymphatic sac tumor (ELST is a rare tumor originating fromendolymphatic epithelium of inner ear. This tumor exhibits low-grade malignancy with benign histopathological appearance and clinically destructive behavior which occurs in the skull base and frequently invades the posterior petrous bone, the mastoid, semicircular canal, cerebellopontine angle structures and cranial nerve. The presence of intracranial ELST always makes the diagnosis challenge for clinicians and pathologists. Herein we describe a case of ELST in skull base. The clinicopathology of this tumor and its differential diagnosis are discussed. Methods The clinical manifestation of a patient with primary ELST occurring in right cerebellopontine angle was presented retrospectively. Resected mass was routinely paraffin-embedded and stained with hematoxylin and eosin. Dako EnVision immunohistochemical staining system was used to detect the tumor antigen expressions, including cytokeratin (CK, vimentin (Vim, epithelial membrane antigen (EMA, carcinoembryonic antigen (CEA, synaptophysin (Syn, chromogranin A (CgA, S-100 protein (S-100, glial fibrillary acidic protein (GFAP, thyroglobulin (TG, thyroid transcription factor-1 (TTF-1 and Ki-67. Results A 32-year-old male patient presented with 20-year history of progressive hearing loss. MRI scan revealed an expansile lytic lesion of the mastoid process of the right petrous bone, measuring 4.20 cm × 3.30 cm × 2.00 cm, occupied the right cerebellopontine angle with infiltration of surrounding dura mater. But the lesion did not break the dura mater and invade the brain parenchyma. Craniotomy was performed and the tumor was removed totally. Histological examination revealed a papillary, cystic or glandular architecture in mass. The papillary and glandular structures were lined by a single layer of flattened cuboidal-to-columnar cells. The stroma of the papillary fronds was richly vascularized and chronically inflamed. There

  13. Treatment of infectious waste: development and testing of an add-on set for used gravity displacement autoclaves.

    Science.gov (United States)

    Stolze, René; Kühling, Jan-Gerd

    2009-06-01

    The safe management of potentially infectious healthcare waste is gaining increasing worldwide importance. In developing countries, simple incinerators are used for the treatment of this type of waste stream. However, as these incinerators produce high emissions and represent the main generators of dioxin and furans in these countries, alternative and cost-effective solutions are needed. As steam treatment systems do not produce persistent organic pollutants, the use of existing (older) medical autoclaves could represent a solution for the treatment of infectious waste. ETLog Health EnviroTech & Logistics, the German-based consulting and engineering company carried out the first research into whether gravity air displacement autoclaves can be used for the safe decontamination of infectious waste. The research showed that it is not possible to decontaminate waste using this type of autoclave. A subsequent research and development phase might, however, make it possible to develop a new process cycle. Tests carried out on the basis of international standards and norms showed that by applying this process cycle and using an add-on set, it is possible to treat healthcare waste using the existing stock of older medical autoclaves. The process cycle and the add-on set developed were tested under existing conditions in Hanoi, Vietnam using the treatment cycle developed for a 13-year-old autoclave. All the parameters for infectious waste decontamination were reached. As modified autoclaves prevent the emission of toxic substances, this approach presents an interim solution, which avoids the impacts on human health and the environment caused by the incineration of healthcare waste.

  14. Endolymphatic Sac Enlargement in a Girl with a Novel Mutation for Distal Renal Tubular Acidosis and Severe Deafness

    Directory of Open Access Journals (Sweden)

    Rink Nikki

    2012-01-01

    Full Text Available Hereditary distal renal tubular acidosis (dRTA is caused by mutations of genes encoding subunits of the H+-ATPase (ATP6V0A4 and ATP6V1B1 expressed in α-intercalated cells of the distal renal tubule and in the cochlea. We report on a 2-year-old girl with distal RTA and profound speech delay which was initially misdiagnosed as autism. Genetic analysis showed compound heterozygous mutations with one known and one novel mutation of the ATP6V1B1 gene; cerebral magnetic resonance imaging (MRI revealed bilateral enlargement of the endolymphatic sacs of the inner ear. With improved cooperation, audiometric testing showed that hearing loss was most profound on the right, where endolymphatic sac enlargement was greatest, demonstrating a clear link between the degree of deafness and the degree of inner ear abnormality. This case indicates the value of MRI for diagnosis of inner ear involvement in very young children with distal RTA. Although citrate therapy quickly corrects the acidosis and restores growth, early diagnosis of deafness is crucial so that hearing aids can be used to assist acquisition of speech and to provide enough auditory nerve stimulation to assure the affected infants remain candidates for cochlear implantation.

  15. Assay and properties of rat yolk sac 25-hydroxyvitamin D/sub 3/ 1. cap alpha. -hydroxylase

    Energy Technology Data Exchange (ETDEWEB)

    Paulson, S.K.; Phelps, M.; DeLuca, H.F.

    1986-11-04

    An in vitro assay has been developed for the rat yolk sac 25-hydroxyvitamin D/sub 3/ 1..cap alpha..-hydroxylase (1..cap alpha..-hydroxylase). The subcellular location and some properties of the enzyme are described. 1,25-Dihydroxyvitamin D/sub 3/ produced from incubations of yolk sac homogenates was extracted, purified by Sephadex LH-20 chromatography and straight- and reverse-phase high-performance liquid chromatography (HPLC), and measured by a competitive binding assay using chick intestinal receptor. The reaction is linear with time for up to 45 min at a substrate concentration of 80 ..mu..M and 4-6 mg/mL microsomal protein. The enzyme, located in the microsomes, requires molecular oxygen and NADPH. Metyrapone (1 x 10/sup -3/ M) was found to inhibit 1-hydroxylation, but a 90% carbon monoxide-10% oxygen atmosphere did not, leaving open the question of involvement of cytochrome P-450. Diphenyl-p-phenylenediamine, a lipid peroxidase inhibitor, inhibited 1..cap alpha..-hydroxylation.

  16. Functional characterization of folic acid transport in the intestine of the laying hen using the everted intestinal sac model.

    Science.gov (United States)

    Tactacan, G B; Rodriguez-Lecompte, J C; Karmin, O; House, J D

    2011-01-01

    Absorption at the level of the intestine is likely a primary regulatory mechanism for the deposition of dietary supplemented folic acid into the chicken egg. Therefore, factors affecting the intestinal transport of folic acid in the laying hen may influence the level of egg folate concentrations. To this end, a series of experiments using intestinal everted sacs were conducted to characterize intestinal folic acid absorption processes in laying hens. Effects of naturally occurring folate derivatives (5-methyl and 10-formyltetrahydrofolate) as well as heme on folic acid absorption were also investigated. Folic acid absorption was measured based on the rate of uptake of (3)H-labeled folic acid in the everted sac from various segments of the small and large intestines. Folic acid concentration, incubation length, and pH condition were optimized before the performance of uptake experiments. The distribution profile of folic acid transport along the intestine was highest in the upper half of the small intestine. Maximum uptake rate (nmol·100 g tissue(-1)·min(-1)) was observed in the duodenum (20.6 ± 1.9) and jejunum (22.3 ± 2.0) and decreased significantly in the ileum (15.3 ± 1.1) and cecum (9.3 ± 0.9). Transport increased proportionately (P laying hen. Uptake of folic acid in the cecum raises the likelihood of absorption of bacterial-derived folate.

  17. Low altitude energetic electron lifetimes after enhanced magnetic activity as deduced from SAC-C and DEMETER data

    Directory of Open Access Journals (Sweden)

    S. Benck

    2010-03-01

    Full Text Available When flux enhancements of energetic electrons are produced as a consequence of geomagnetic storm occurrence, they tend to vanish gradually when the magnetic activity calms down and the fluxes decay to quiet-time levels. We use SAC-C and DEMETER low altitude observations to estimate the energetic electron lifetimes (E=0.16–1.4 MeV, L=1.6–5, B=0.22–0.46 G and compare the decay rates to those observed at high altitude. While crossing the radiation belts at high latitude, the SAC-C and DEMETER instruments sample particles with small equatorial pitch angles (αeq<18° for L>2.5 whereas the comparison is done with other satellite data measured mainly in the equatorial plane (for αeq>75°. While in the inner belt and in the slot region no significant lifetime differences are observed from the data sets with different αeq, in the outer belt, for the least energetic electrons (<500 keV, the lifetimes are up to ~3 times larger for the electrons with the equatorial pitch-angle close to the loss cone than for those mirroring near the equator. The difference decreases with increasing energy and vanishes for energies of about 1 MeV.

  18. ADD3可变剪接在结肠癌与正常组织间的差异表达%Differential expression of ADD3 splicing isoforms between colorectal cancer and normal mucosa tissues

    Institute of Scientific and Technical Information of China (English)

    陶敏; 黄良祥; 蔡鹏威; 晋龙; 吴文冰; 曾长青; 黄毅; 伍严安

    2016-01-01

    AIM:To investigate the relationship between the expression of adducin 3 (ADD3) and its splicing isoforms and colorectal cancer (CRC).METHODS:The expression of ADD3, ADD3-Ia and ADD3-Ib in 50 pair of CRC tissues , 20 pairs of colorectal polyp tissues , and 2 CRC cell lines SW480 and SW620 before and after oxaliplatin or fluoroura-cil intervention were detected by real-time PCR.The cell activity was determined by MTT assay , the cell migration ability was evaluated by wound-healing assay , and the cell invasion ability was measured by Transwell assay .RESULTS:The expres-sion levels of ADD3 and ADD3-Ib were decreased in the CRC tissues as compared with the normal mucous (P<0.01), and ADD3-Ia/Ib ratio was increased in the CRC tissues (P<0.01).The expression level of ADD3-Ia was higher in T3-4 group than that in T1-2 group (P<0.05).Reduced expression of ADD3, ADD3-Ia and ADD3-Ib in colorectal polyps was observed compared with the normal tissues (P<0.01).Compared with the SW480 cells, the expression levels of ADD3-Ia and ADD3-Ib were lower (P<0.05) and the ADD3-Ia/Ib ratio was higher (P <0.01) in the SW620 cells.After treated with oxalipla-tin or fluorouracil, the cell activity, migration and invasion in the SW620 and SW480 cells were weakened accompanied by the increases in the expression levels of ADD 3, ADD3-Ia and ADD3-Ib to various certain extents .CONCLUSION:In CRC there is a tendency that ADD3-Ib reduction leads to ADD3 decrease, accompanied by an increased ADD3-Ia/Ib ratio.The expression changes of ADD 3 and its splicing isoforms in the CRC may be relevant to its invasion ability .%目的:探讨内收蛋白3(ADD3)及其剪接体与结直肠癌(CRC)的关系。方法:Real-time PCR方法检测50对CRC组织、20对结直肠息肉组织、经5-氟尿嘧啶(5-FU )或奥沙利铂干预前后的SW480(低转移性)和SW620(高转移性)结肠癌细胞中ADD3-、ADD3-Ia和ADD3-Ib的表达量。用MTT检测细胞的活力,用划痕实验检测

  19. Toxicity of parathion on embryo and yolk-sac larvae of gilthead seabream (Sparus aurata l.): effects on survival, cholinesterase, and carboxylesterase activity.

    Science.gov (United States)

    Arufe, M Isabel; Arellano, Juana M; Albendín, Gemma; Sarasquete, Carmen

    2010-12-01

    This study was conducted to examine the acute toxicity of the organophosphorus pesticide (OP) parathion on embryos and yolk-sac larvae of gilthead seabream (Sparus aurata), and to investigate the effects of this compound on cholinesterase and carboxylesterase activity of seabream larvae in the phase of endogenous feeding. The 72-h LC50 for yolk-sac larvae (0.523 mg L⁻¹) was about two-fold lower than the 48-h LC50 for embryos (1.005 mg L⁻¹). Parathion significantly inhibited the activity of ChE and CaE activity in yolk sac larvae but there were not significant differences in the sensitivity of both esterases to parathion as inferred by their 72-h IC50 values. Larvae exposed to parathion for 72 h showed a 70% inhibition of the whole body acetylcholinesterase at approximately the LC50.

  20. JAWS: Just Add Water System - A device for detection of nucleic acids in Martian ice caps

    DEFF Research Database (Denmark)

    Hansen, Anders J.; Willerslev, Eske; Mørk, Søren

    2002-01-01

    The design of a device for nucleic acid detection in the Martian ice caps is presented; the Just Add Water System (JAWS). It is based on fiber-optic PNA (peptide nucleic acid) light up probe random microsphere universal array technology. JAWS is designed to be part of a larger system with a regul......The design of a device for nucleic acid detection in the Martian ice caps is presented; the Just Add Water System (JAWS). It is based on fiber-optic PNA (peptide nucleic acid) light up probe random microsphere universal array technology. JAWS is designed to be part of a larger system...... to the planet from Earth....

  1. Add-on effect of Brahmi in the management of schizophrenia

    Directory of Open Access Journals (Sweden)

    Sukanto Sarkar

    2012-01-01

    Full Text Available Brahmi(Bacopa monnieri, an Ayurvedic herb has primarily been used to enhance cognitive ability, memory and learning skills. We present a case study of schizophrenia in which add-on Brahmi extracts 500 mg/day for a period of one month resulted in reduction in psychopathology without any treatment-emergent adverse effect. Although preliminary, our case study suggests therapeutic efficacy of add-on Brahmi in schizophrenia, thus opening up a new dimension of its role in alternative medicines.

  2. Morphoproteomics Identifies the EZH2 and SIRT1 Pathways as Potential Blocks to Differentiation in Yolk Sac Tumor of the Ovary and Provides Therapeutic Options: a Case Study.

    Science.gov (United States)

    Kojima, Yumi A; Assylbekova, Binara; Zhao, Bihong; Nugent, Elizabeth; Brown, Robert E

    2017-01-01

    Yolk sac tumor of the ovary is a rare but highly malignant and aggressive germ cell tumor. The objective of this case study of an ovarian yolk sac tumor was to identify putative pathways that are known to pose a block in differentiation, both in early embryogenesis and in tumorigenesis, that might be amenable to low toxicity therapies designed to promote differentiation to a more benign state and prevent recurrent disease in such tumors. The enhancer of Zeste homolog 2 (EZH2), a histone methyl transferase, and silent mating type information regulation 2 homolog 1 (SIRT1), a NAD+ histone deacetylase, are two such pathways.

  3. CAS is to organize the establishment of new national professional standardization technical committees, subcommittees & working groups under the commissioning of SAC

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ To implement the development strategy, bringing standardization into full play in technically supporting the construction of socialism market economy of China, achieving the task of development and revision of national standards, upgrading the level of standardization development of China, fully realizing the leaping development of our standardization course, the Standardization Administration of China (SAC) has decided to expand the scale of national professional standardization technical committee system. Currently, the China Association for Standardization (CAS), under the commissioning of SAC, is to organize the establishment of new national professional standardization technical committees, subcommittees and working groups.

  4. Evaluation for High-risk HPV in Squamous Cell Carcinomas and Precursor Lesions Arising in the Conjunctiva and Lacrimal Sac.

    Science.gov (United States)

    Afrogheh, Amir H; Jakobiec, Frederick A; Hammon, Rebecca; Grossniklaus, Hans E; Rocco, James; Lindeman, Neal I; Sadow, Peter M; Faquin, William C

    2016-04-01

    High-risk human papilloma virus (HR-HPV) is a well-established causative agent of oropharyngeal squamous cell carcinoma (SCC). In addition, HR-HPV has occasionally been reported to be present in dysplastic and malignant lesions of the conjunctiva and lacrimal sac, although its overall incidence and etiological role in periocular SCC are controversial. Sequential surgical samples of 52 combined cases of invasive SCC (I-SCC) and SCC in situ (SCCIS) from 2 periocular sites (conjunctiva and lacrimal sac) diagnosed over a 14-year period (2000 to 2014) were selected for evaluation, and relevant patient characteristics were documented. p16 immunohistochemistry was performed as a screening test. All p16-positive cases were further evaluated for HR-HPV using DNA in situ hybridization (DNA ISH), and a subset was also analyzed by polymerase chain reaction (PCR). Of 43 ocular surface squamous neoplasias (OSSNs), 30% (n=13; 8 SCCIS and 5 I-SCC cases) were positive for HR-HPV. HPV-positive OSSNs occurred in 8 men and 5 women with a mean age of 60 years (range, 39 to 94 y). HPV type-16 was detected in all conjunctival cases evaluated by PCR. All 5 conjunctival I-SCCs were nonkeratinizing (n=4) or partially keratinizing (n=1) and managed by simple excision. In contrast, HPV-negative conjunctival I-SCCs were predominantly keratinizing (11 keratinizing and 2 nonkeratinizing). Of 9 lacrimal sac I-SCCs (LSSCCs), 66.7% (n=6) were positive for HR-HPV by p16 and DNA ISH; HPV subtypes were HPV-16 (n=5) and HPV-58 (n=1). In addition, 2 p16-positive cases with negative DNA ISH results were HR-HPV positive (HPV-16 and HPV-33) when evaluated by PCR, suggesting that the rate of HR-HPV positivity among the LSSCCs may be as high as 89% (n=8). The combined group of HR-HPV-positive LSSCCs was seen in 4 men and 4 women with a mean age of 60 years (range, 34 to 71 y). Seven of the 8 HPV-positive LSSCCs (87.5%) had a nonkeratinizing or partially keratinizing histomorphology, whereas 1 case (12

  5. Expression of histamine receptors in the human endolymphatic sac: the molecular rationale for betahistine use in Menieres disease.

    Science.gov (United States)

    Møller, M Nue; Kirkeby, S; Vikeså, J; Nielsen, F Cilius; Caye-Thomasen, P

    2016-07-01

    The human endolymphatic sac (ES) is situated in a duplicature of the dura in the posterior cranial fossa and constitutes a part of the inner ear. The sac possesses immunological capacities and is responsible for a major part of the trans-epithelial ion transport occurring within the inner ear, via molecular mechanisms similar to that of the kidney collecting duct epithelia. Dysfunction of the trans-epithelial ion transport has been hypothesized as the reason for the endolymphatic hydrops occurring in Menieres diseases. Thus, candidate drug selection for medical treatment of Menieres disease has been based on a potential capability of improving trans-epithelial ion transport. However, recent human studies seems to rule out diuretic therapy and The Committee for Medicinal Products for Human Use redrew the recommendation for trimetazidine (Vastarel) treatment in the management of Meniere disease in 2012. This leaves betahistine (Betaserc) as the only drug for potential prevention of the incapacitating attacks of dizziness, tinnitus and hearing loss. However, the histamine receptors targeted by betahistine have never been demonstrated in the human ES. Accordingly, this study aims to investigate the expression of histamine receptors of the human ES epithelium and sub-epithelial stroma. Following sampling of human endolymphatic sac tissue during translabyrinthine surgery, the expression of histamine receptor genes was determined by cDNA microarray analysis. Results were subsequently verified by immuno-histochemistry. The combined results of microarrays and immuno-histochemistry showed expression of the histamine receptor HRH1 in the epithelial lining of the ES, whereas HRH3 was expressed exclusively in the sub-epithelial capillary network. Receptors HRH2 and -4 were not expressed. The present data provide the first direct evidence of a molecular rationale for betahistine treatment in Menieres disease. A potential betahistine effect in Menieres disease may primarily be

  6. Neural biomarkers for dyslexia, ADHD and ADD in the auditory cortex of children

    Directory of Open Access Journals (Sweden)

    Bettina Serrallach

    2016-07-01

    Full Text Available Dyslexia, attention deficit hyperactivity disorder (ADHD, and attention deficit disorder (ADD show distinct clinical profiles that may include auditory and language-related impairments. Currently, an objective brain-based diagnosis of these developmental disorders is still unavailable. We investigated the neuro-auditory systems of dyslexic, ADHD, ADD, and age-matched control children (N=147 using neuroimaging, magnet-encephalography and psychoacoustics. All disorder subgroups exhibited an oversized left planum temporale and an abnormal interhemispheric asynchrony (10-40 ms of the primary auditory evoked P1-response. Considering right auditory cortex morphology, bilateral P1 source waveform shapes, and auditory performance, the three disorder subgroups could be reliably differentiated with outstanding accuracies of 89-98%. We therefore for the first time provide differential biomarkers for a brain-based diagnosis of dyslexia, ADHD, and ADD. The method allowed not only a clear discrimination between two subtypes of attentional disorders (ADHD and ADD, a topic controversially discussed for decades in the scientific community, but also revealed the potential for objectively identifying comorbid cases. Noteworthy, in children playing a musical instrument, after three and a half years of training the observed interhemispheric asynchronies were reduced by about 2/3, thus suggesting a strong beneficial influence of music experience on brain development. These findings might have far-reaching implications for both research and practice and enable a profound understanding of the brain-related etiology, diagnosis, and musically based therapy of common auditory-related developmental disorders and learning disabilities.

  7. Vocabulario enla lengua Castellana, la del Ynga y Xebera (British Library, Ms. Add. 25,323)

    NARCIS (Netherlands)

    Alexander-Bakkerus, A.

    2013-01-01

    The codex Vocabulario enla Lengua Castellana, la del Inga y Xebera (British Library, shelf mark Ms. Add. 25,323), does not only contain a Spanish-Quechua-Xebero vocabulary, but also a rather elaborate description of certain Xebero sounds. Although the author of the manuscript is unknown, we may attr

  8. How to Add Philosophy Dimensions in Your Basic International Business Course

    Science.gov (United States)

    Thanopoulos, John

    2010-01-01

    This article aims to assist professors in introducing concepts of self, philosophy, religions, the universe, existential dilemmas, etc., in their basic international business classes. Using active learning and five-member student teams, a student organized and administered conference adds a very useful dimension of knowledge sacrificing only one…

  9. Project DyAdd: Implicit Learning in Adult Dyslexia and ADHD

    Science.gov (United States)

    Laasonen, Marja; Väre, Jenni; Oksanen-Hennah, Henna; Leppämäki, Sami; Tani, Pekka; Harno, Hanna; Hokkanen, Laura; Pothos, Emmanuel; Cleeremans, Axel

    2014-01-01

    In this study of the project DyAdd, implicit learning was investigated through two paradigms in adults (18-55 years) with dyslexia (n?=?36) or with attention deficit/hyperactivity disorder (ADHD, n?=?22) and in controls (n?=?35). In the serial reaction time (SRT) task, there were no group differences in learning. However, those with ADHD exhibited…

  10. Neural Biomarkers for Dyslexia, ADHD, and ADD in the Auditory Cortex of Children

    Science.gov (United States)

    Serrallach, Bettina; Groß, Christine; Bernhofs, Valdis; Engelmann, Dorte; Benner, Jan; Gündert, Nadine; Blatow, Maria; Wengenroth, Martina; Seitz, Angelika; Brunner, Monika; Seither, Stefan; Parncutt, Richard; Schneider, Peter; Seither-Preisler, Annemarie

    2016-01-01

    Dyslexia, attention deficit hyperactivity disorder (ADHD), and attention deficit disorder (ADD) show distinct clinical profiles that may include auditory and language-related impairments. Currently, an objective brain-based diagnosis of these developmental disorders is still unavailable. We investigated the neuro-auditory systems of dyslexic, ADHD, ADD, and age-matched control children (N = 147) using neuroimaging, magnetencephalography and psychoacoustics. All disorder subgroups exhibited an oversized left planum temporale and an abnormal interhemispheric asynchrony (10–40 ms) of the primary auditory evoked P1-response. Considering right auditory cortex morphology, bilateral P1 source waveform shapes, and auditory performance, the three disorder subgroups could be reliably differentiated with outstanding accuracies of 89–98%. We therefore for the first time provide differential biomarkers for a brain-based diagnosis of dyslexia, ADHD, and ADD. The method allowed not only allowed for clear discrimination between two subtypes of attentional disorders (ADHD and ADD), a topic controversially discussed for decades in the scientific community, but also revealed the potential for objectively identifying comorbid cases. Noteworthy, in children playing a musical instrument, after three and a half years of training the observed interhemispheric asynchronies were reduced by about 2/3, thus suggesting a strong beneficial influence of music experience on brain development. These findings might have far-reaching implications for both research and practice and enable a profound understanding of the brain-related etiology, diagnosis, and musically based therapy of common auditory-related developmental disorders and learning disabilities. PMID:27471442

  11. An ADD/DROP procedure for the capacitated plant location problem

    Directory of Open Access Journals (Sweden)

    Bornstein Claudio Thomas

    2004-01-01

    Full Text Available The capacitated plant location problem with linear transportation costs is considered. Exact rules and heuristics are presented for opening or closing of facilities. A heuristic algorithm based on ADD/DROP strategies is proposed. Procedures are implemented with the help of lower and upper bounds using Lagrangean relaxation. Computational results are presented and comparisons with other algorithms are made.

  12. ATRX ADD Domain Links an Atypical Histone Methylation Recognition Mechanism to Human Mental-Retardation Syndrome

    Energy Technology Data Exchange (ETDEWEB)

    S Iwase; B Xiang; S Ghosh; T Ren; P Lewis; J Cochrane; C Allis; D Picketts; D Patel; et al.

    2011-12-31

    ATR-X (alpha-thalassemia/mental retardation, X-linked) syndrome is a human congenital disorder that causes severe intellectual disabilities. Mutations in the ATRX gene, which encodes an ATP-dependent chromatin-remodeler, are responsible for the syndrome. Approximately 50% of the missense mutations in affected persons are clustered in a cysteine-rich domain termed ADD (ATRX-DNMT3-DNMT3L, ADD{sub ATRX}), whose function has remained elusive. Here we identify ADD{sub ATRX} as a previously unknown histone H3-binding module, whose binding is promoted by lysine 9 trimethylation (H3K9me3) but inhibited by lysine 4 trimethylation (H3K4me3). The cocrystal structure of ADD{sub ATRX} bound to H3{sub 1-15}K9me3 peptide reveals an atypical composite H3K9me3-binding pocket, which is distinct from the conventional trimethyllysine-binding aromatic cage. Notably, H3K9me3-pocket mutants and ATR-X syndrome mutants are defective in both H3K9me3 binding and localization at pericentromeric heterochromatin; thus, we have discovered a unique histone-recognition mechanism underlying the ATR-X etiology.

  13. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Iwase, Shigeki; Xiang, Bin; Ghosh, Sharmistha; Ren, Ting; Lewis, Peter W.; Cochrane, Jesse C.; Allis, C. David; Picketts, David J.; Patel, Dinshaw J.; Li, Haitao; Shi, Yang (Harvard-Med); (Ottawa Hosp.); (MSKCC); (Rockefeller); (CH-Boston); (Tsinghua); (Mass. Gen. Hosp.)

    2011-07-19

    ATR-X (alpha-thalassemia/mental retardation, X-linked) syndrome is a human congenital disorder that causes severe intellectual disabilities. Mutations in the ATRX gene, which encodes an ATP-dependent chromatin-remodeler, are responsible for the syndrome. Approximately 50% of the missense mutations in affected persons are clustered in a cysteine-rich domain termed ADD (ATRX-DNMT3-DNMT3L, ADD{sub ATRX}), whose function has remained elusive. Here we identify ADD{sub ATRX} as a previously unknown histone H3-binding module, whose binding is promoted by lysine 9 trimethylation (H3K9me3) but inhibited by lysine 4 trimethylation (H3K4me3). The cocrystal structure of ADD{sub ATRX} bound to H3{sub 1-15}K9me3 peptide reveals an atypical composite H3K9me3-binding pocket, which is distinct from the conventional trimethyllysine-binding aromatic cage. Notably, H3K9me3-pocket mutants and ATR-X syndrome mutants are defective in both H3K9me3 binding and localization at pericentromeric heterochromatin; thus, we have discovered a unique histone-recognition mechanism underlying the ATR-X etiology.

  14. Impact of Number of Add/Drop Ports of OXCs on LSP Blocking Performance

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    This paper describes the connection establishment of label switched paths (LSP) in IP/MPLS over optical networks. Our investigations on two typical network topologies show that the number of add/drop ports of OXCs has a significant impact on the LSP blocking performance.

  15. Associations between Dopamine and Serotonin Genes and Job Satisfaction: Preliminary Evidence from the Add Health Study

    Science.gov (United States)

    Song, Zhaoli; Li, Wendong; Arvey, Richard D.

    2011-01-01

    Previous behavioral genetic studies have found that job satisfaction is partially heritable. We went a step further to examine particular genetic markers that may be associated with job satisfaction. Using an oversample from the National Adolescent Longitudinal Study (Add Health Study), we found 2 genetic markers, dopamine receptor gene DRD4 VNTR…

  16. Break out of the box: how to add value to the security function.

    Science.gov (United States)

    Jones, Russell F

    2007-01-01

    Opportunities to create programs that enhance the value of the security function are present now and will be in the future, according to the author, who illustrates a number of ways the resourceful security practitioner can add to his department's reputation and his organization's bottom line.

  17. Design and Implementation of 10 Gbps Optical Add-Drop Transponder

    Institute of Scientific and Technical Information of China (English)

    Byoung-Sung; Kim; Seung-Il; Myong; Jung-Chan; Lee; Je-Soo; Ko

    2003-01-01

    10 Gbps optical add-drop transponder, which can accommodate VSR (very short reach) to LR (long reach) subnetworks, is designed and implemented. The transponder consists of an OCA (optical transport network connection assembly), a SCA (sub-network connection assembly), and a FECA (forward error correction assembly).

  18. Civic Engagement and Global Citizenship in a University Context: Core Business or Desirable Add-On?

    Science.gov (United States)

    Munck, Ronaldo

    2010-01-01

    Can civic engagement become a "core business" of the contemporary university, or is it an attractive "add-on" that is not affordable in the current economic climate? Contemporary universities often play an important role in local community development and, as such, have the opportunity to develop civic engagement strategies to…

  19. Comparison Study on Three Different Reconfigurable Optical Add Drop Multiplexer Architectures

    Institute of Scientific and Technical Information of China (English)

    ZHOU Bin; ZHANG Yang-an; HUANG Yong-qing; REN Xiao-min

    2007-01-01

    In this paper, we present the evolution of reconfigurable optical add drop multiplexer(ROADM) technologies, and compare three main ROADM architectures available on the market today. Three architectures include broadcast-select and demux-switch-mux[and the integrated version planar lightwave circuit(PLC)] and wavelengths-selective switch.

  20. Ritanserin as add-on medication to neuroleptic therapy for patients with chronic or subchronic schizophrenia

    NARCIS (Netherlands)

    Den Boer, JA; Vahlne, JO; Post, P; Heck, AH; Daubenton, F; Olbrich, R

    2000-01-01

    The effect of ritanserin, a potent 5HT(2A/2C) receptor antagonist, used as an add-on medication to neuroleptic treatmentin patients with schizophrenia, was compared with that of placebo, in an international, double-blind, parallel-group study. Previously established neuroleptic therapy was maintaine

  1. Ciprofloxacin and probiotic Escherichia coli Nissle add-on treatment in active ulcerative colitis

    DEFF Research Database (Denmark)

    Petersen, Andreas Munk; Mirsepasi, Hengameh; Halkjær, Sofie Ingdam;

    2014-01-01

    BACKGROUND AND AIM: Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The probiotic bacterium Escherichia coli Nissle 1917 (EcN) has been used to maintain and induce clinical remission in UC. Our aim was to test the effect of Ciprofloxacin and/or orally administered EcN as add...

  2. Psychometric Properties and Norms of the German ABC-Community and PAS-ADD Checklist

    Science.gov (United States)

    Zeilinger, Elisabeth L.; Weber, Germain; Haveman, Meindert J.

    2011-01-01

    Aim: The aim of the present study was to standardize and generate psychometric evidence of the German language versions of two well-established English language mental health instruments: the "Aberrant Behavior Checklist-Community" (ABC-C) and the "Psychiatric Assessment Schedule for Adults with Developmental Disabilities" (PAS-ADD) Checklist. New…

  3. Structural requirements of organophosphorus insecticides (OPI) to inhibit chicken yolk sac membrane kynurenine formamidase related to OPI teratogenesis.

    Science.gov (United States)

    Seifert, Josef

    2013-03-01

    This paper provides new information related to the mechanism of OPI (organophosphorus insecticides) teratogenesis. The COMFA (comparative molecular field analysis) and COMSIA (comparative molecular similarity indices analysis) suggest that the electrostatic and steric fields are the best predictors of OPI structural requirements to inhibit in ovo chicken embryo yolk sac membrane kynurenine formamidase, the proposed target for OPI teratogens. The dominant electrostatic interactions are localized at nitrogen-1, nitrogen-3, nitrogen of 2-amino substituent of the pyrimidinyl of pyrimidinyl phosphorothioates, and the oxygen of crotonamide carbonyl in crotonamide phosphates. Bulkiness of the substituents at carbon-2 and carbon-6 of the pyrimidinyls and/or N-substituents and carbon-3 substituents of crotonamides are the steric structural components that contribute to superiority of those OPI as in ovo inhibitors of kynurenine formamidase.

  4. Direct aneurysm sac catheterization and embolization of an enlarging internal iliac aneurysm using cone-beam CT

    Science.gov (United States)

    Merchant, Monish; Shah, Rohan; Resnick, Scott

    2015-01-01

    Since cone-beam computed tomography (CT) has been adapted for use with a C-arm system it has brought volumetric CT capabilities in the interventional suite. Although cone-beam CT image resolution is far inferior to that generated by traditional CT scanners, the system offers the ability to place an access needle into position under tomographic guidance and use the access to immediately begin a fluoroscopic procedure without moving the patient. We describe a case of a “jailed” enlarging internal iliac artery aneurysm secondary to abdominal aortic aneurysm repair, in which direct percutaneous puncture of the internal iliac artery aneurysm sac was performed under cone-beam CT guidance. PMID:25858522

  5. β1- and β2-adrenergic stimulation-induced electrogenic transport by human endolymphatic sac epithelium and its clinical implications

    Science.gov (United States)

    Kim, Bo Gyung; Kim, Jin Young; Jung, JinSei; Moon, In Seok; Yoon, Joo-Heon; Choi, Jae Young; Kim, Sung Huhn

    2017-01-01

    The endolymphatic sac (ES) is a cystic structure of the inner ear connected to the cochlea and vestibule, which plays a role in regulating ion homeostasis in inner ear fluid. Disruption of ion homeostasis can cause inner ear disorders with hearing loss and dizziness, such as Meniere’s disease. Herein, we found, for the first time, functional evidence for the involvement of β1- and β2-adrenergic receptors in apical electrogenic ion transport by human ES epithelium by using electrophysiological/pharmacological and molecular biological methods, which were dependent on K+ and Cl− ion transport. The apical electrogenic transport was absent or very weak in ES epithelia of patients with Meniere’s disease. These results suggested that adrenergic stimulation via β1- and β2-adrenergic receptors in the human ES was involved in regulation of inner ear fluid ion homeostasis and impairment of this response could be a pathological mechanism of Meniere’s disease. PMID:28165045

  6. Proposed helmet PET geometries with add-on detectors for high sensitivity brain imaging

    Science.gov (United States)

    Tashima, Hideaki; Yamaya, Taiga

    2016-10-01

    For dedicated brain PET, we can significantly improve sensitivity for the cerebrum region by arranging detectors in a compact hemisphere. The geometrical sensitivity for the top region of the hemisphere is increased compared with conventional cylindrical PET consisting of the same number of detectors. However, the geometrical sensitivity at the center region of the hemisphere is still low because the bottom edge of the field-of-view is open, the same as for the cylindrical PET. In this paper, we proposed a helmet PET with add-on detectors for high sensitivity brain PET imaging for both center and top regions. The key point is the add-on detectors covering some portion of the spherical surface in addition to the hemisphere. As the location of the add-on detectors, we proposed three choices: a chin detector, ear detectors, and a neck detector. For example, the geometrical sensitivity for the region-of-interest at the center was increased by 200% by adding the chin detector which increased the size by 12% of the size of the hemisphere detector. The other add-on detectors gave almost the same increased sensitivity effect as the chin detector did. Compared with standard whole-body-cylindrical PET, the proposed geometries can achieve 2.6 times higher sensitivity for brain region even with less than 1/4 detectors. In addition, we conducted imaging simulations for geometries with a diameter of 250 mm and with high resolution depth-of-interaction detectors. The simulation results showed that the proposed geometries increased image quality, and all of the add-on detectors were equivalently effective. In conclusion, the proposed geometries have high potential for widespread applications in high-sensitivity, high-resolution, and low-cost brain PET imaging.

  7. CM5, a pre-Swarm comprehensive geomagnetic field model derived from over 12 yr of CHAMP, Ørsted, SAC-C and observatory data

    DEFF Research Database (Denmark)

    Sabaka, Terence J.; Olsen, Nils; Tyler, Robert H.;

    2015-01-01

    A comprehensive magnetic field model named CM5 has been derived from CHAMP, Orsted and SAC-C satellite and observatory hourly-means data from 2000 August to 2013 January using the Swarm Level-2 Comprehensive Inversion (CI) algorithm. Swarm is a recently launched constellation of three satellites ...

  8. Dietary amino acids fed in free form or as protein do differently affect amino acid absorption in a rat everted sac model

    NARCIS (Netherlands)

    Nolles, J.A.; Peeters, I.G.S.; Bremer, B.I.; Moorman, R.; Koopmanschap, R.E.; Verstegen, M.W.A.; Schreurs, V.V.A.M.

    2008-01-01

    In the present study, the effect of free amino acid (FAA) diets on the intestinal absorption rate of methionine and leucine was studied 'ex vivo' with rats adapted for different periods of time to the diets, using the everted sac method. The adaptation period to the 21% FAA diet with an amino acid c

  9. Ovule-to-seed development in Dovyalis caffra (Salicaceae: Flacourtieae with notes on the taxonomic significance of the extranucellar embryo sac

    Directory of Open Access Journals (Sweden)

    E. M. A. Steyn

    2005-12-01

    Full Text Available Dovyalis caffra (Hook.f. & Harv. Hook.f. is a widespread and horticulturally important southern African endemic. Here described, ovule-to-seed development represents the first embryological information on this genus of the tribe Flacourtieae, Salicaceae  sensu lato. Results are discussed in the light of data available on the embryology of the order Malpighiales in general and on the tribe Flacourtieae in particular. It is clear that Dovyalis E.Mey. ex Am. shares many characters with other members of the Flacourtieae. Ovules of D. caffra are anatropous. bitegmic and crassinucellate with both bisporic Allium- and monosporic Polygonum-type embryo sacs. One of the most characteristic embryological features of the tribe is the pres­ence of an unusual, extranucellar embryo sac that stretches halfway up into the micropyle. Since this extraordinary-shaped embryo sac also defines the embryo sacs of Salix L. and Populus L., it is suggested that the character provides strong sup­port for the proposed close phylogenetic link between tribes Flacourtieae and Saliceae of Salicaceae sensu lato.

  10. Generic Environmental Impact Statement. Air Force Low Altitude Flying Operations. Preliminary Draft. Volume 3

    Science.gov (United States)

    1990-01-01

    and Marketing ORNL Oak Ridge National Laboratory PSD Prevention of Significant Deterioration RAs Restricted Areas SAC Strategic Air Command SO 2 sulfur...resources under IR-700. However, significant impacts have not been reported to the New York Department of Agriculture and Markets (Butcher 1987...nesting of bald eagles at particular sites in Salt River and Verde River canyons, which is an important issue with 3 birdwatchers . The preservation of

  11. MR imaging of the lumbar disk herniation : relationship between the direction of herniated disc and pressure effect on nerve root and dural sac

    Energy Technology Data Exchange (ETDEWEB)

    Cha, B. H.; Shon, M. Y.; Kim, K. W.; Lim, M. A.; Kwon, K. R; Kim, S. S. [Sunlin Presbyterian Hospital, Pohang (Korea, Republic of)

    1996-04-01

    To evaluate the relationship between the direction of herniated disc and pressure effect on nerve root and dural sac, as seen on MRI. We retrospectively reviewed lumbar spine MR images of 122 cases of lumbar disk herniation 75 patients MRI findings were analyzed with regard to the relationship between the direction of the herniated disc and pressure effect on nerve root and dural sac. Pressure effect on nerve root and dural sac was arbitrarily divided into three types. Type I was defined as zero or minimal compression of nerve roots or thecal sac by the herniated disc ; type II was defined as mild to moderate compression, while III was defined as severe compression or displacement of nerve roots and/or thecal sac. Of the 122 cases seen in these 75 patients, 97(80%) were observed at L4-5 and L5-S1. The central type(71cases ; 58%) was more frequently observed than the posterolateral type(48cases ; 40%) or lateral type(3cases ; 2%). The totals of types I, II, and III were 44(36%), 43(35%) and 35 cases(29%), respectively. Seventy-seven %(34/44) of type I and 65%(28/43) of type II were of the central type but for type III, the corresponding figure was only 26%(9/35). On MR imaging, most of lumbar disk herniations were observed at L4-5 and L5-S1, with a predominance of the central type rather than the posterolateral one. Most of the central types were either type I or type II.

  12. Monolithically integrated reconfigurable add-drop multiplexer for mode-division-multiplexing systems.

    Science.gov (United States)

    Wang, Shipeng; Wu, Hao; Tsang, Hon Ki; Dai, Daoxin

    2016-11-15

    An integrated reconfigurable optical add-drop multiplexer (ROADM) for mode-division-multiplexing systems is proposed and demonstrated for the first time, to the best of our knowledge. The present ROADM with four mode-channels is composed of a four-channel mode demultiplexer, four identical 2×2 thermo-optic Mach-Zehnder switches (MZSs), and a four-channel mode multiplexer, which are integrated monolithically on silicon. All the devices are designed for operation with TM polarization. The ROADM can add/drop any one of the mode channels freely by thermally turning on/off the corresponding MZS. For the added/dropped mode-channels, the excess loss is 1-5 dB, and the extinction ratio is 15-20 dB in the wavelength range of 1535-1565 nm.

  13. Add-on treatment of aripiprazole in an adult onychophagia patient

    Directory of Open Access Journals (Sweden)

    Mehmet Cemal Kaya

    2012-12-01

    Full Text Available Nail biting (onychophagia is a common disorder whichhas not been investigated yet. There are different opinionsabout to classify onychophagia, but according toDSM-IV-TR it is classified as impulse control disorder nototherwise specified. The knowledge about treatment ofonychophagia is limited. There are a few studies abouttreatment of onychophagia with psychotherapy and astudy with pharmacotherapy. Some studies suggest thatan atypical antipsychotic aripiprazole may have beneficialeffects in the treatment of impulse control disorders. Inthis study we report a case of onychophagia which hassuccessfully treated with aripiprazole add-on to escitalopramtreatment that has never reported before. J Clin ExpInvest 2012; 3(4: 545-547Key words: Onychophagia, aripiprazole, add-on treatment

  14. How can Facilities Management Add Value to Organisations as well as to Society

    DEFF Research Database (Denmark)

    Jensen, Per Anker; Sarasoja, Anna-Liisa; van der Voordt, Theo

    2013-01-01

    Network and Value Adding Management. Besides adding value for the core business of organisations it is becoming increasingly important for FM to add value for society, for instance in terms of sustainability and corporate social responsibility. The advancement in knowledge and understanding presented...... group. The project applied three basic theoretical perspectives: FM, Corporate Real Estate Management (CREM) and Business to Business (B2B) marketing and started with a major literature review on added value based on each of these perspectives. The collaboration included a series of workshops...... models are presented and compared. They include parameters and strategies for how FM can add value with many similarities and a trend towards convergence. Stakeholder relationships and relationship management are seen as crucial in adding value, which for instance is expressed in the concepts FM Value...

  15. The Politics, Development and Problems of Small Irrigation Dams in Malawi: Experiences from Mzuzu ADD

    OpenAIRE

    Bryson Gwiyani Nkhoma

    2011-01-01

    The paper examines the progress made regarding the development of small irrigation dams in Malawi with the view of establishing their significance in improving rural livelihoods in the country. The paper adopts a political economy theory and a qualitative research approach. Evidence from Mzuzu Agricultural Development Division (ADD), where small reservoirs acquire specific relevance, shows that despite the efforts made, the development of small dams is making little progress. The paper highli...

  16. Bilateral Waveform Similarity Overlap-and-Add Based Packet Loss Concealment for Voice over IP

    Directory of Open Access Journals (Sweden)

    J.F. Yeh

    2013-08-01

    Full Text Available This paper invested a bilateral waveform similarity overlap-and-add algorithm for voice packet lost. Since Packet lost will cause the semantic misunderstanding, it has become one of the most essential problems in speech communication. This investment is based on waveform similarity measure using overlap-and-Add algorithm and provides the bilateral information to enhance the speech signal reconstruction. Traditionally, it has been improved that waveform similarity overlap-and-add (WSOLA technique is an effective algorithm to deal with packet loss concealment (PLC for real-time time communication. WSOLA algorithm is widely applied to deal with the length adaptation and packet loss concealment of speech signal. Time scale modification of audio signal is one of the most essential research topics in data communication, especially in voice of IP (VoIP. Herein, the proposed the bilateral WSOLA (BWSOLA that is derived from WSOLA. Instead of only exploitation one direction speech data, the proposed method will reconstruct the lost voice data according to the preceding and cascading data. The related algorithms have been developed to achieve the optimal reconstructing estimation. The experimental results show that the quality of the reconstructed speech signal of the bilateral WSOLA is much better compared to the standard WSOLA and GWSOLA on different packet loss rate and length using the metrics PESQ and MOS. The significant improvement is obtained by bilateral information and proposed method. The proposed bilateral waveform similarity overlap-and-add (BWSOLA outperforms the traditional approaches especially in the long duration data loss.

  17. Waveguide structure optimization of arrayed waveguide gratings concatenation in cascaded optical add/drop multiplexers

    Institute of Scientific and Technical Information of China (English)

    Yuanliang Chu(初元量); Hanyi Zhang(张汉一)

    2003-01-01

    The dimensions of input waveguide and output waveguide of arrayed waveguide gratings (AWGs) determinethe crosstalk, insertion loss and 1-dB bandwidth. In cascaded optical add/drop multiplexers (OADMs),the value of these parameters will largely affect the power penalty of system. The power penalty ofcascaded OADMs is calculated with different waveguide dimensions of AWGs in this paper. Consideringof wavelength misalignment, an optimization design of AWGs is obtained.

  18. Long-distance regulation of Add2 pre-mRNA3′end processing

    Science.gov (United States)

    Nedeljkovic, Mirjana; Costessi, Luisa; Iaconcig, Alessandra; Porro, Fabiola; Muro, Andrés F.

    2013-01-01

    Accurate 3′end processing depends on the correct recognition of polyadenylation regulatory elements by specific protein complexes. In addition to the well-known hexanucleotide motif and downstream sequence element (DSE), less-defined auxiliary elements are usually found to modulate cleavage and polyadenylation. They are generally located in close proximity to the core polyadenylation elements but, in most of the cases, the molecular mechanisms involved are not well defined. We concentrated our studies on the regulation of the mouse β adducin (Add2) pre-mRNA cleavage and polyadenylation. It contains two proximal erythroid-specific (PAS1 and PAS2-3) and one distal brain-specific (PAS4) polyadenylation sites along the 3′UTR. Using an in vivo approach based in the transfection of minigenes containing the Add2 polyadenylation signals, we previously identified the core regulatory elements responsible for PAS4 activity. Here, we have identified two novel non-canonical cis-acting elements regulating 3′end processing at PAS4, which show long-distance activities. The first of these elements, which spans for 257 nucleotides and is located at more than 5 kb upstream the PAS4, was essential to enable processing at the Add2 PAS4. The second element, located at about 4.5 kb upstream of the PAS4, reduces PAS4 processing. Both elements display long-distance activities and, to our knowledge, long-distance upstream polyadenylation regulatory elements have not been previously described in non-viral eukaryotic transcripts. These results highlight the complexity of the regulatory mechanisms directing Add2 pre-mRNA 3′end processing, and suggests that pre-mRNA 3′ end processing of other genes may also be unexpectedly regulated by non-canonical auxiliary elements. PMID:23411391

  19. Effectiveness of clobazam as add-on therapy in children with refractory focal epilepsy

    OpenAIRE

    2006-01-01

    The objective of this study was to evaluate the safety and efficacy of clobazam in children with refractory focal epilepsy. We investigated 100 consecutive patients concerning etiology of epilepsy, previously used antiepileptic drugs, seizure frequency and adverse events. Clobazam was introduced as add-on therapy in patients with previous failure of at least two monotherapies. Mean age was eight years-old and 39 patients were girls. Clobazam mean dosage was 23.6 mg/day. Mean use of clobazam w...

  20. Reduction in Endometrioma Size with Three Months of Aromatase Inhibition and Progestin Add-Back.

    Science.gov (United States)

    Agarwal, Sanjay K; Foster, Warren G

    2015-01-01

    The purpose of this study was to assess the impact of 3 months of aromatase inhibition together with progestin add-back on ovarian endometrioma size. This prospective cohort study was performed at University Medical Center (UC San Diego). Women trying to conceive were excluded. After informed consent, all women were treated with the aromatase inhibitor letrozole (5 mg/d) with norethindrone acetate (5 mg/d) add-back for 3 months. Pre- and posttreatment assessments of endometrioma sizes were performed by ultrasound. The impact of treatment on pain was determined using the patient assessed endpoints of the Biberoglu and Behrman scale. These included assessing dysmenorrhea, dyspareunia, and nonmenstrual pelvic pain each on a scale from 0 to 3. The primary endpoint of this study was the change in ultrasound documented endometrioma size. Fourteen endometriomas in 8 consecutive women were treated for 3 m. Mean endometrioma diameter decreased 50% from 4.6 ± 1.6 cm to 2.3 ± 1.6 cm (mean ± SD). This represents a 75% decrease in endometrioma volume. Endometriosis symptoms of dysmenorrhea, dyspareunia, and nonmenstrual pelvic pain also improved with treatment. In conclusion, a 3-month course of high dose aromatase inhibition with progestin add-back significantly reduces ovarian endometrioma size and warrants further investigation.

  1. The Dnmt3L ADD Domain Controls Cytosine Methylation Establishment during Spermatogenesis

    Directory of Open Access Journals (Sweden)

    Georgios Vlachogiannis

    2015-02-01

    Full Text Available A critical aspect of mammalian gametogenesis is the reprogramming of genomic DNA methylation. The catalytically inactive adaptor Dnmt3L is essential to ensuring this occurs correctly, but the mechanism by which it functions is unclear. Using gene targeting to engineer a single-amino-acid mutation, we show that the Dnmt3L histone H3 binding domain (ADD is necessary for spermatogenesis. Genome-wide single-base-resolution DNA methylome analysis of mutant germ cells revealed overall reductions in CG methylation at repetitive sequences and non-promoter CpG islands. Strikingly, we also observe an even more severe loss of non-CG methylation, suggesting an unexpected role for the ADD in this process. These epigenetic deficiencies were coupled with defects in spermatogonia, with mutant cells displaying marked changes in gene expression and reactivation of retrotransposons. Our results demonstrate that the Dnmt3L ADD is necessary for Dnmt3L function and full reproductive fitness.

  2. THERIAK_D: An add-on to implement equilibrium computations in geodynamic models

    Science.gov (United States)

    Duesterhoeft, Erik; Capitani, Christian

    2013-11-01

    This study presents the theory, applicability, and merits of the new THERIAK_D add-on for the open source Theriak/Domino software package. The add-on works as an interface between Theriak and user-generated scripts, providing the opportunity to process phase equilibrium computation parameters in a programming environment (e.g., C or MATLAB®). THERIAK_D supports a wide range of features such as calculating the solid rock density or testing the stability of mineral phases along any pressure-temperature (P-T) path and P-T grid. To demonstrate applicability, an example is given in which the solid rock density of a 2-D-temperature-pressure field is calculated, portraying a simplified subduction zone. Consequently, the add-on effectively combines thermodynamics and geodynamic modeling. The carefully documented examples could be easily adapted for a broad range of applications. THERIAK_D is free, and the program, user manual, and source codes may be downloaded from http://www.min.uni-kiel.de/˜ed/theriakd/.

  3. DYNAMIC OPTIMIZATION OF OVERLAPAND-ADD LENGTH OVER MBOFDM SYSTEM BASED ON SNR AND CIR ESTIMATE

    Directory of Open Access Journals (Sweden)

    Nouri Naziha

    2014-12-01

    Full Text Available An important role performed by Zero Padding (ZP in multi-band OFDM (MB-OFDM System. This role show for low-complexity in résistance against multipath interference by reducing inter-carrier interference (ICI and eliminating the inter-symbol interference (ISI Also, zeropadded suffix can be used to eliminate ripples in the power spectral density in order to conform to FCC requirements. At the receiver of MB-OFDM system needs to use of a technique called as overlap-and-add (OLA. Which maintain the circular convolution property and take the multipath energy of the channel. In this paper, we proposed a method of performing overlap-and-add length for zero padded suffixes. Then, we studied the effect of this method, dynamic optimization of overlap-and-add (OLA equalization, on the performance of MBOFDM system on Bit Error Rate (BER with AWGN channel and Saleh-Valenzuela (S-V Multipath channel Model. In the dynamic optimization OLA, the Length of ZP depends on length of channel impulse response (CIR. These measures, based on SNR, insert the ZP according to the measurement. Dynamic optimization of length of ZP improves the Performance of MBOFDM system. In fact we developed a technique to select the length of ZP as function of SNR and CIR estimate(repetition. In our simulation this technique improve to 3 dB at BER=10-2 with a multipath channels CM4.

  4. 75 FR 73091 - Medicare Program; Town Hall Meeting on the Fiscal Year 2012 Applications for Add-on Payments for...

    Science.gov (United States)

    2010-11-29

    ... Fiscal Year 2012 Applications for Add-on Payments for New Medical Services and Technologies Under the...) of the Social Security Act (the Act) to discuss fiscal year (FY) 2012 applications for add-on... Town Hall Meeting, whether attending in person or by phone, must register and submit their agenda...

  5. 40 CFR Table 1 to Subpart Jjjj of... - Operating Limits if Using Add-On Control Devices and Capture System

    Science.gov (United States)

    2010-07-01

    ... Limits if Using Add-On Control Devices and Capture System If you are required to comply with operating... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Operating Limits if Using Add-On Control Devices and Capture System 1 Table 1 to Subpart JJJJ of Part 63 Protection of...

  6. 40 CFR Table 1 to Subpart Ssss of... - Operating Limits if Using Add-on Control Devices and Capture System

    Science.gov (United States)

    2010-07-01

    ... Using Add-on Control Devices and Capture System If you are required to comply with operating limits by... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Operating Limits if Using Add-on Control Devices and Capture System 1 Table 1 to Subpart SSSS of Part 63 Protection of...

  7. 40 CFR Table 2 to Subpart Oooo of... - Operating Limits if Using Add-On Control Devices and Capture System

    Science.gov (United States)

    2010-07-01

    ... OOOO of Part 63—Operating Limits if Using Add-On Control Devices and Capture System If you are required... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Operating Limits if Using Add-On Control Devices and Capture System 2 Table 2 to Subpart OOOO of Part 63 Protection of...

  8. The MMPI-168(L) and ADD in Assessing Psychopathology in Individuals with Mental Retardation: Between and within Instrument Associations.

    Science.gov (United States)

    McDaniel, William F.; Passmore, Corie E.; Sewell, Hollie M.

    2003-01-01

    A study involving 58 adults with mental retardation and mental disorders found few correlations between the Minnesota Multiphasic Personality Inventory (MMPI) and the Assessment of Dual Diagnosis (ADD). The major exception was the Mania scale of the MMPI, which correlated moderately well with the ADD Schizophrenia and Dementia scales. (Contains…

  9. Evaluation of Potential Average Daily Doses (ADDs) of PM2.5 for Homemakers Conducting Pan-Frying Inside Ordinary Homes under Four Ventilation Conditions

    Science.gov (United States)

    Lee, Seonyeop; Yu, Sol; Kim, Sungroul

    2017-01-01

    Several studies reported that commercial barbecue restaurants likely contribute to the indoor emission of particulate matters with a diameter of 2.5 micrometers or less (PM2.5) while pan-frying meat. However, there is inadequate knowledge of exposure level to indoor PM2.5 in homes and the contribution of a typical indoor pan-frying event. We measured the indoor PM2.5 concentration and, using Monte-Carlo simulation, estimated potential average daily dose (ADD) of PM2.5 for homemakers pan-frying a piece of pork inside ordinary homes. Convenience-based sampling at 13 homes was conducted over four consecutive days in June 2013 (n = 52). Although we pan-fried 100 g pork for only 9 min, the median (interquartile range, IQR) value was 4.5 (2.2–5.6) mg/m3 for no ventilation and 0.5 (0.1–1.3) mg/m3 with an active stove hood ventilation system over a 2 h sampling interval. The probabilities that the ADDs from inhalation of indoor PM2.5 would be higher than the ADD from inhalation of PM2.5 on an outdoor roadside (4.6 μg/kg·day) were 99.44%, 97.51%, 93.64%, and 67.23%, depending on the ventilation conditions: (1) no window open; (2) one window open in the kitchen; (3) two windows open, one each in the kitchen and living room; and (4) operating a forced-air stove hood, respectively. PMID:28098788

  10. Histological and ultrastructural observation of the ink sac of Octopus variabilis%长蛸墨囊的组织学及其墨腺超微结构

    Institute of Scientific and Technical Information of China (English)

    王亚; 王春琳; 詹萍萍; 宋微微; 母昌考; 邵楚; 刘帅

    2011-01-01

    分析了长蛸墨囊组织学及墨腺细胞的超微结构.结果表明,墨囊由墨囊体、导管和墨腺3部分组成,墨囊壁和导管壁分为外膜、肌肉层、粘膜下层和粘膜层,墨囊壁与肝脏外膜紧密相连,墨囊导管开口于直肠末端近肛门处;墨腺集中在墨囊底部靠近肝脏的一侧,由粘膜上皮细胞向囊腔内增生形成,呈索状,腺体中部含丰富的结缔组织;墨腺细胞分为具有无分泌功能的A型细胞和有分泌功能的B型细胞,微绒毛分布于B型细胞的顶端;墨汁颗粒在墨腺细胞囊泡中形成,并以胞吐或细胞破碎的形式将墨汁颗粒排出.%Octopus variabilis has become one of the most popular seafood for its delicious taste, which has large market demand in China and is advantaged in marine products exports. However, due to the over fishing and water pollution, the natural resource of Octopus variabilis declined rapidly. For this reason,the industry of artificial culturing got rapid development. The Octopus variabilis will spurt the ink when meeting the stimulation originally. The peculiar ink defence system of Octopus variabilis is based on the activity of the highly specialized ink gland which is deputed to the continuous production of the black insoluble melanin pigment that is stored in the ink sac. This organ has been studied in other cephalopod, but the ink gland in Octopus variabilis is different from the others. Therefore, the histology of the ink sac and ultrastructural structure of the ink gland of Octopus variabilis was studied using light microscopy and electron microscopy in this paper. The observed results showed that the ink sac was composed of ink sac body, pipe and ink glands. The ink sac of Octopus variabilis opened into the end of the recta near the anus by pipe. The wall of the ink sac and pipe were both composed of epicardial,muscular layer,submucosa layer and mucosa layer. And the epicardial of ink sac wall were stratified squamous

  11. Effect of egg weight on composition, embryonic growth, and expression of amino acid transporter genes in yolk sac membranes and small intestines of the domestic pigeon (Columba livia).

    Science.gov (United States)

    Chen, M X; Li, X G; Yan, H C; Wang, X Q; Gao, C Q

    2016-06-01

    The objective of this study was to investigate the effect of egg weight on the composition of the egg, the growth of the embryo, and the expression of amino acid transporter genes in the yolk sac membranes and small intestines of the domestic pigeon (Columba livia). A total of 240 fertilized eggs were collected and divided into two groups based on the weight of the eggs, light (LE) and heavy (HE). The composition of 20 eggs from each group was measured, and the remaining eggs were weighed and placed in an incubator. On embryonic days (E) 9, 11, 13, and 15 and day of hatch (DOH), 15 embryos/hatchlings from each group were measured for embryonic growth, and samples were collected. The HE had heavier yolk and albumen weights than the LE (P < 0.01). Compared with the LE, the HE had heavier yolk-free embryonic body and yolk sac weights from E13 to DOH (P < 0.05). Additionally, the HE had larger yolk sac membrane weights from E13 to E15 (P < 0.05) and had more residual yolk sac content on DOH than those of the LE (P < 0.01). The yolk absorption was greater for the HE than for the LE from E11 to E13 (P < 0.05). Furthermore, the abundance of CAT2 and PepT1 mRNA in the yolk sac membranes was greater in the HE than in the LE on E13 (P < 0.05). Compared with the LE, the gene expression of EAAT2 in the intestine on E13 was greater in the HE, whereas the expression of EAAT3 was lower in the HE (P < 0.05). Taken together, our results suggest that egg weight influenced the composition of the eggs, embryonic development, and expression of amino acid transporter genes in the yolk sac membranes and small intestines of pigeon embryos.

  12. Air gun injury with deadly aftermath--case report.

    Science.gov (United States)

    Stankov, Aleksandar; Jakovski, Zlatko; Pavlovski, Goran; Muric, Nedzat; Dwork, Andrew J; Cakar, Zdravko

    2013-01-01

    In Republic of Macedonia the use of air guns is quite widespread. They are used mainly for target practice. They are regulated by the Law of Arms, where they are defined as pneumatic weapons. There is no legal limit on type or quantity of ammunition that one may possess. Our Institute performs at least 90% of the forensic autopsies in Macedonia. In this report we describe the only fatality by pneumatic weapon to come to our attention over the past 10 years. A 6-year-old girl was accidentally wounded by her brother when he and his father were trying a new air gun, a 4.5mm single shot, break barrel, spring piston air rifle manufactured in China under the brand "Westlake". She died within minutes. Autopsy showed cardiac tamponade due to penetration of the aorta. A 0.5g metal projectile, 4.5mm in diameter, with a pointed, conical shape, was recovered from the pericardial sac.

  13. 40 CFR Table 1b to Subpart Dddd of... - Add-on Control Systems Compliance Options

    Science.gov (United States)

    2010-07-01

    ... CATEGORIES National Emission Standards for Hazardous Air Pollutants: Plywood and Composite Wood Products Pt... new affected sources only); reconstituted wood product presses; softwood veneer dryer heated...

  14. The presence of 19-norandrostenedione and its sulphate form in yolk-sac fluid of the early equine conceptus.

    Science.gov (United States)

    Raeside, J I; Christie, H L

    2008-01-01

    C(18) neutral steroid formation by cytochrome P450 aromatase has been recorded for several equine and porcine tissues. High activity of P450 aromatase is reflected in the quantities of estrogens in yolk-sac (y-s) fluid of early equine conceptuses. In a previous study of y-s fluid we detected large amounts of androgens by radioimmunoassay (RIA), using an antiserum for androstenedione (A(4)). Here, we report that RIA, following chromatography, gave tentative identification of the major peak as norandrostenedione (19-norA) not as A(4). Furthermore, even greater quantities of 19-norA seemed to be present in y-s fluid as a sulphoconjugate, as noted from extraction, solvolysis, HPLC, followed by RIA. Confirmation of these unusual findings was attained after further purification with two HPLC systems and definitive identification by LC-MS with an authentic standard of 19-norA. Initial extraction of the steroid sulphate as a methylene-blue complex also yielded 19-norA suggesting that the 3-enol form had enabled sulphoconjugation. The biological significance of retention mainly as a sulphate is not known; however, the large amounts of 19-norA found in the fluid accords well with reports on the catalytic activity shown in vitro by the blastocyst isozyme of P450 aromatase in the pig and horse.

  15. Giant prosthesis for reinforcement of visceral sac for complex bilateral and recurrent inguinal hernias: a prospective evaluation.

    Directory of Open Access Journals (Sweden)

    Thapar V

    2000-04-01

    Full Text Available AIMS: To evaluate giant prosthesis for reinforcement of visceral sac (GPRVS as a treatment for complex bilateral and recurrent inguinal hernias. SUBJECTS AND METHODS: The prospective study carried out in a single surgical unit at a tertiary health care center involved consecutive series of 31 patients with complex bilateral and recurrent inguinal hernias who underwent GPRVS. All were men and the mean age was 58 years (range 49-95 years. Factors predicting high risk for recurrence included a large hernia ( greater, similar5cms, 32%, 10/31 patients, failure of one or more previous repairs (45%, 14/31 patients, chronic obstructive pulmonary disease (25%, 8/31 patients and poor muscle tone (70%, 22/31 patients. Operative time, length of postoperative stay, complications and death were the main outcome measures. RESULTS: Mean -/+ SEM operative time was 65 -/+ 11 minutes (range 45-115 minutes. Mean -/+ SEM length of stay was 3.5 -/+ 0.7 days (range 2-5 days. There were 4 minor complications, but no mesh infections and death. Follow up was obtained for a mean period of 14.6 months (range 12-23 months; there were no recurrences. CONCLUSION: GPRVS provides a definitive and safe cure for repair of complex bilateral and recurrent inguinal hernias because of its simplicity, ease of the procedure, good results and low recurrence rate.

  16. Detection of CD2 expression in chicken hematogenic embryo yolk sac lymphoid cells prior to thymus genesis

    Institute of Scientific and Technical Information of China (English)

    Dongyu Zhou; Jigui Wang; Weiquan Liu; Rongxiu Liu; Yuehu Pei

    2008-01-01

    Lymphoid mononuclear cells from chick embryos at stage 16 were collected prior to fetal liver and thymus genesis to study the differentiation and function of the hematogenic yolk sac and to detect whether CD2 occurs on the surface of lymphoid mononuclear cells.The phenotype and functional activity of the cell surface protein E receptor and the ultrastructure of embryonic E+ cells were compared with those of mature T cells.Our results indicate 99.36% homology between the E receptors of embryonic lymphocytes and mature T cells.Other similarities,including molecular distribution,motivation,the ability to form an erythrocyte rosette,the structure of the receptor-ligand complex,and the conformation of the signal channel,were detected between embryonic lymphocytes and mature CD2-expressing T cells.These results indicate that CD2 is already expressed prior to fetal fiver and thymus genesis and that its expression is not dependent on the thymic microenvironment.

  17. SAC305/Cu微焊点界面金属间化合物生长速率

    Institute of Scientific and Technical Information of China (English)

    王建华; 孟工戈; 孙凤莲

    2015-01-01

    界面金属间化合物(IMC)的生长速率是影响钎焊接头可靠性的重要因素.文中研究了焊点尺寸、时效温度及镍镀层对SAC305/Cu微焊点界面IMC生长速率的影响.结果表明,焊球尺寸为200,300,400和500 μm,时效温度为100,130,160℃条件下,界面IMC层厚度生长速率随时效时间平方根数值的升高而增长.焊点尺寸由小变大,界面IMC层厚度更薄,IMC的生长速率也更小.随着时效温度的升高,界面IMC生长速率增大.镍镀层对界面IMC的生长速率有明显的抑制作用,即降低IMC生长速率,使其增厚变缓.

  18. Structure of the yellow sac spider Cheiracanthium punctorium genes provides clues to evolution of insecticidal two-domain knottin toxins.

    Science.gov (United States)

    Sachkova, M Y; Slavokhotova, A A; Grishin, E V; Vassilevski, A A

    2014-08-01

    Yellow sac spiders (Cheiracanthium punctorium, family Miturgidae) are unique in terms of venom composition, because, as we show here, two-domain toxins have replaced the usual one-domain peptides as the major constituents. We report the structure of the two-domain Che. punctorium toxins (CpTx), along with the corresponding cDNA and genomic DNA sequences. At least three groups of insecticidal CpTx were identified, each consisting of several members. Unlike many cone snail and snake toxins, accelerated evolution is not typical of cptx genes, which instead appear to be under the pressure of purifying selection. Both CpTx modules present the inhibitor cystine knot (ICK), or knottin signature; however, the sequence similarity between the domains is low. Conversely, notable similarity was found between separate domains of CpTx and one-domain toxins from spiders of the Lycosidae family. The observed chimerism is a landmark of exon shuffling events, but in contrast to many families of multidomain protein genes no introns were found in the cptx genes. Considering the possible scenarios, we suggest that an early transcription-mediated fusion event between two related one-domain toxin genes led to the emergence of a primordial cptx-like sequence. We conclude that evolution of toxin variability in spiders appears to be quite different from other venomous animals.

  19. The European Union, Financial Crises and the Regulation of Hedge Funds: A Policy Cul-de-Sac or Policy Window?

    Directory of Open Access Journals (Sweden)

    David John Lutton

    2008-11-01

    Full Text Available A series of financial crises involving hedge funds has created a general perception that action needs to be taken. A number of key member states and political actors favour tighter regulation. Traditional bureaucratic theory suggests that the European Commission would seek to maximise this ‘policy window’, and yet there remains no single unified European Union (EU regulatory framework specifically targeting hedge funds. The nature of the regulatory regime, which has generally demanded a ‘light touch’ approach, means there are strict limits the EU’s ability to act. From an EU perspective, hedge fund regulation appears to be a policy cul-de-sac. However, the relationship between hedge funds and financial crisis is complex and less straightforward than is often portrayed. Hedge fund regulation cannot, however, be considered in isolation but should be viewed in the context of a wider programme to integrate European financial services markets. Viewed from this perspective, EU regulation is in fact changing the landscape of the hedge fund industry through a process of negative integration.

  20. Occurrence of differential meiotic associations and additional chromosomes in the embryo-sac mother cells of Allium roylei Stearn

    Indian Academy of Sciences (India)

    Geeta Sharma; Ravinder N. Gohil

    2011-04-01

    A small population of complex translocation heterozygote plants of Allium roylei from the Bani region of Jammu Province was studied for meiosis in the female track. This study resulted in identification of two variants, having embryo-sac mother cells (EMCs) with more than 16 chromosomes. EMCs of the remaining plants invariably had diploid $(2n = 16)$ chromosome complement. Female meiosis, in general, was found to be abnormal, with nearly 23% and 11% chromosomes associating as quadrivalents or trivalents at prophase I and at metaphase I, respectively. This was followed by irregular segregation of chromosomes at anaphase I. Amongst the variants; one had 38% EMCs with eight bivalents plus two small sized chromosomes. Their small size, dispensable nature and tendency to affect the pairing behaviour of normal complement are some of the features that latter chromosomes share with the B chromosomes. Seventeen to nineteen chromosomes were observed in 35% EMCs of other variant; the remaining cells had 16 chromosomes. Chromosomal behaviour in both kind of cells (euploid and aneuploid) was more or less similar. Unlike female meiocytes, male meiocytes analysed earlier of this strain always had 16 chromosomes which paired to form extremely complex associations involving 3–16 chromosomes. The most likely cause of this asynchrony with regards to number of chromosomes involved in multivalent formation seems to be interaction of genes controlling chiasma formation with the different physiological conditions of male and female meiocytes.

  1. What's next after metformin? focus on sulphonylurea: add-on or combination therapy

    Directory of Open Access Journals (Sweden)

    Lim PC

    2015-09-01

    Full Text Available Introduction: The pathophysiology of type 2 diabetes (T2DM mainly focused on insulin resistance and insulin deficiency over the past decades. Currently, the pathophysiologies expanded to ominous octet and guidelines were updated with newer generation of antidiabetic drug classes. However, many patients had yet to achieve their target glycaemic control. Although all the guidelines suggested metformin as first line, there was no definite consensus on the second line drug agents as variety of drug classes were recommended. Objectives: The aim of this review was to evaluate the drug class after metformin especially sulphonylurea and issues around add-on or fixed dose combination therapy. Methods: Extensive literature search for English language articles, clinical practice guidelines and references was performed using electronic databases. Results: Adding sulphonylurea to metformin targeted both insulin resistance and insulin deficiency. Sulphonylurea was efficacious and cheaper than thiazolidinedione, dipeptidyl peptidase-4 inhibitor, glucagon-like peptide 1 analogue and insulin. The main side effect of sulphonylurea was hypoglycaemia but there was no effect on the body weight when combining with metformin. Fixed dose sulphonylurea/metformin was more efficacious at lower dose and reported to have fewer side effects with better adherence. Furthermore, fixed dose combination was cheaper than add-on therapy. In conclusion, sulphonylurea was feasible as the second line agent after metformin as the combination targeted on two pathways, efficacious, cost-effective and had long safety history. Fixed dose combination tablet could improve patient’s adherence and offered an inexpensive and more efficacious option regardless of original or generic product as compared to add-on therapy.

  2. U.S. Air Force Environmental Assessment, Add To and Alter Type III Hydrant Fueling System, Tinker Air Force Base, Oklahoma

    Science.gov (United States)

    2011-12-01

    provides a vital, secure communications link to the submerged fleet of ballistic missile submarines. OC-ALC airframe artisans perform depot work on the...wetland areas no longer existed or were actually drainage ditches or wet-weather conveyances that did not function as wetlands or aquatic habitat

  3. Frequency-Domain Chromatic Dispersion Equalization Using Overlap-Add Methods in Coherent Optical System

    CERN Document Server

    Xu, Tianhua; Popov, Sergei; Forzati, Marco; Martensson, Jonas; Mussolin, Marco; Li, Jie; Wang, Ke; Zhang, Yimo; Friberg, Ari T

    2016-01-01

    The frequency domain equalizers (FDEs) employing two types of overlap-add zero-padding (OLA-ZP) methods are applied to compensate the chromatic dispersion in a 112-Gbit/s non-return-to-zero polarization division multiplexed quadrature phase shift keying (NRZ-PDM-QPSK) coherent optical transmission system. Simulation results demonstrate that the OLA-ZP methods can achieve the same acceptable performance as the overlap-save method. The required minimum overlap (or zero-padding) in the FDE is derived, and the optimum fast Fourier transform length to minimize the computational complexity is also analyzed.

  4. Can metabolomics in addition to genomics add to prognostic and predictive information in breast cancer?

    Science.gov (United States)

    Howell, Anthony

    2010-11-16

    Genomic data from breast cancers provide additional prognostic and predictive information that is beginning to be used for patient management. The question arises whether additional information derived from other 'omic' approaches such as metabolomics can provide additional information. In an article published this month in BMC Cancer, Borgan et al. add metabolomic information to genomic measures in breast tumours and demonstrate, for the first time, that it may be possible to further define subgroups of patients which could be of value clinically. See research article: http://www.biomedcentral.com/1471-2407/10/628.

  5. Compact wavelength add-drop multiplexers using Bragg gratings in coupled dielectric-loaded plasmonic waveguides

    CERN Document Server

    Biagi, Giulio; Radko, Ilya P; Rubahn, Horst-Günter; Pedersen, Kjeld; Bozhevolnyi, Sergey I

    2016-01-01

    We report a novel design of a compact wavelength add-drop multiplexer utilizing dielectric-loaded surface plasmon-polariton waveguides (DLSPPWs). The DLSPPW-based configuration exploits routing properties of directional couplers and filtering abilities of Bragg gratings. We present practical realization of a 20-$\\mu$m-long device operating at telecom wavelengths that can reroute optical signals separated by approximately 70 nm in the wavelength band. We characterize the performance of the fabricated structures using scanning near-field optical microscopy as well as leakage-radiation microscopy and support our findings with numerical simulations.

  6. Novel optical add-drop multiplexer for wavelength-division-multiplexing networks

    Science.gov (United States)

    Peng, Peng-Chun; Chang, Ching-Hung; Lu, Hai-Han; Lin, Yi-Tzai; Sun, Jen-Wei; Jiang, Chang-Han

    2012-06-01

    Two novel optical add-drop multiplexer (OADM) with different self-healing functionalities for reliable wavelength-division-multiplexing networks are presented and demonstrated. Single or multiple failure-link traffics can be bi-directionally restored without the need for wavelength conversion or extra backup fiber links. To evaluate the performances of the proposed structures, a 77-channel CATV signal is experimentally transmitted with a favorable carrier-to-noise ratio (CNR), composite second-order (CSO) and composite triple beat (CTB) performances.

  7. MetaEasy: A Meta-Analysis Add-In for Microsoft Excel

    Directory of Open Access Journals (Sweden)

    Evangelos Kontopantelis

    2009-04-01

    Full Text Available Meta-analysis is a statistical methodology that combines or integrates the results ofseveral independent clinical trials considered by the analyst to be `combinable' (Huque1988. However, completeness and user-friendliness are uncommon both in specialisedmeta-analysis software packages and in mainstream statistical packages that have to relyon user-written commands. We implemented the meta-analysis methodology in an Mi-crosoft Excel add-in which is freely available and incorporates more meta-analysis models(including the iterative maximum likelihood and prole likelihood than are usually avail-able, while paying particular attention to the user-friendliness of the package.

  8. Significant treatment effect of add-on ketamine anesthesia in electroconvulsive therapy in depressive patients: A meta-analysis.

    Science.gov (United States)

    Li, Dian-Jeng; Wang, Fu-Chiang; Chu, Che-Sheng; Chen, Tien-Yu; Tang, Chia-Hung; Yang, Wei-Cheng; Chow, Philip Chik-Keung; Wu, Ching-Kuan; Tseng, Ping-Tao; Lin, Pao-Yen

    2017-01-01

    Add-on ketamine anesthesia in electroconvulsive therapy (ECT) has been studied in depressive patients in several clinical trials with inconclusive findings. Two most recent meta-analyses reported insignificant findings with regards to the treatment effect of add-on ketamine anesthesia in ECT in depressive patients. The aim of this study is to update the current evidence and investigate the role of add-on ketamine anesthesia in ECT in depressive patients via a systematic review and meta-analysis. We performed a thorough literature search of the PubMed and ScienceDirect databases, and extracted all relevant clinical variables to compare the antidepressive outcomes between add-on ketamine anesthesia and other anesthetics in ECT. Total 16 articles with 346 patients receiving add-on ketamine anesthesia in ECT and 329 controls were recruited. We found that the antidepressive treatment effect of add-on ketamine anesthesia in ECT in depressive patients was significantly higher than that of other anesthetics (p<0.001). This significance persisted in both short-term (1-2 weeks) and moderate-term (3-4 weeks) treatment courses (all p<0.05). However, the side effect profiles and recovery time profiles were significantly worse in add-on ketamine anesthesia group than in control group. Our meta-analysis highlights the significantly higher antidepressive treatment effect of add-on ketamine in depressive patients receiving ECT compared to other anesthetics. However, clinicians need to take undesirable side effects into consideration when using add-on ketamine anesthesia in ECT in depressive patients.

  9. Homology of the internal sac components in the leaf beetle subfamily Criocerinae and evolutionary novelties related to the extremely elongated flagellum.

    Science.gov (United States)

    Matsumura, Yoko; Yoshizawa, Kazunori

    2012-05-01

    Extremely elongated intromittent organs are found in a wide range of taxa, especially among insects. This phenomenon is generally thought to result from sexual selection, but it is predicted that limited storage space in the body cavity and the difficulty of using the elongated organs should have constrained the evolution of extreme elongation, neutralizing any selective advantage. Therefore, in groups with long intromittent organs, features that overcome these constraints may have evolved or coevolved together with intromittent organ elongation. Using a comparative morphological approach and outgroup comparisons, we identified potential constraints and key novelties that may neutralize such constraints in the leaf beetle subfamily Criocerinae. Observations of the internal sac structure throughout Criocerinae were performed. Comparing the results with preceding studies from outgroups, a ground plan of the criocerine internal sac was constructed. Our analysis also identified specific features that are always correlated with extreme elongation: the rotation of whole internal-sac sclerites and the possession of a pocket in which to store the elongated flagellum. The pocket is thought to be formed by the rotation of the sclerites, markedly altering internal sac shape from the criocerine ground plan. Onlythe clades that have acquired this derived state contain species with an elongated flagellum that distinctly exceeds the median lobe length. It is presumed that these character correlations evolved independently three times. The detected character correlations corroborate the hypothesis that there are latent adaptive constraints for the evolution of extremely elongated intromittent organs. The constraints may have been neutralized by the alteration from the criocerine ground plan resulting in the formation of a storage pocket. In conclusion, deviation from the criocerine ground plan is considered to be the evolutionary innovation that neutralized the latent adaptive

  10. Study on the Processing Technology of Suspended Beverage of Orange Sacs%柑橘砂囊悬浮饮料生产工艺的研究

    Institute of Scientific and Technical Information of China (English)

    陈艳; 谢婧; 冉旭

    2011-01-01

    以新鲜槿柑为原料,通过碱处理法去除囊衣:橘瓣在温度为80℃、质量分数为0.5%的NaOH溶液中保持5min,可制备出颗粒饱满、含汁较多的砂囊。采用正交试验设计,确定了复配悬浮剂与砂囊用量的最优组合。结果表明:琼脂添加量0.8g/kg,CMC添加量4g/kg,砂囊添加量30g/kg时,制得的柑橘砂囊悬浮饮料稳定性好、果粒悬浮均匀。通过试验得出产品的配方,所得的柑橘砂囊悬浮饮料酸甜适宜、清凉爽口,而且有咀嚼果肉的爽脆感。%Suspended beverage of orange sacs was developed using fresh citrus as the main raw material. Orange sac has the characteristics of full pellet and rich juice, through the alkali treatment removing capsule clothes, under the conditions of 0.5%NaOH 80 ℃ keeping 5 min. The production processing of suspended beverage of orange sacs was discussed in this study by the orthogonal experiment design. Results show that the optimal combination for cloudy agency and orange sac: agar 0.8 g/kg, CMC additives 4 g/kg, juice sac dosage 30 g/kg.Suspended drink has appropriate sour and sweet, cool and refreshing, and crisp feeling by chewing the pulp.

  11. The Fourier Imaging X-ray Spectrometer (FIXS) for the Argentinian, Scout-launched satelite de Aplicaciones Cienficas-1 (SAC-1)

    Science.gov (United States)

    Dennis, Brian R.; Crannell, Carol JO; Desai, Upendra D.; Orwig, Larry E.; Kiplinger, Alan L.; Schwartz, Richard A.; Hurford, Gordon J.; Emslie, A. Gordon; Machado, Marcos; Wood, Kent

    1988-01-01

    The Fourier Imaging X-ray Spectrometer (FIXS) is one of four instruments on SAC-1, the Argentinian satellite being proposed for launch by NASA on a Scout rocket in 1992/3. The FIXS is designed to provide solar flare images at X-ray energies between 5 and 35 keV. Observations will be made on arcsecond size scales and subsecond time scales of the processes that modify the electron spectrum and the thermal distribution in flaring magnetic structures.

  12. Presence of an isoform of H+-pyrophosphatase located in the alveolar sacs of a scuticociliate parasite of turbot: physiological consequences.

    Science.gov (United States)

    Mallo, Natalia; Lamas, Jesús; Defelipe, Ana-Paula; Decastro, Maria-Eugenia; Sueiro, Rosa-Ana; Leiro, José-Manuel

    2016-04-01

    H+-pyrophosphatases (H+-PPases) are integral membrane proteins that couple pyrophosphate energy to an electrochemical gradient across biological membranes and promote the acidification of cellular compartments. Eukaryotic organisms, essentially plants and protozoan parasites, contain various types of H+-PPases associated with vacuoles, plasma membrane and acidic Ca+2 storage organelles called acidocalcisomes. We used Lysotracker Red DND-99 staining to identify two acidic cellular compartments in trophozoites of the marine scuticociliate parasite Philasterides dicentrarchi: the phagocytic vacuoles and the alveolar sacs. The membranes of these compartments also contain H+-PPase, which may promote acidification of these cell structures. We also demonstrated for the first time that the P. dicentrarchi H+-PPase has two isoforms: H+-PPase 1 and 2. Isoform 2, which is probably generated by splicing, is located in the membranes of the alveolar sacs and has an amino acid motif recognized by the H+-PPase-specific antibody PABHK. The amino acid sequences of different isolates of this ciliate are highly conserved. Gene and protein expression in this isoform are significantly regulated by variations in salinity, indicating a possible physiological role of this enzyme and the alveolar sacs in osmoregulation and salt tolerance in P. dicentrarchi.

  13. Observations of OM/OC and specific attenuation coefficients (SAC in ambient fine PM at a rural site in central Ontario, Canada

    Directory of Open Access Journals (Sweden)

    T. W. Chan

    2010-03-01

    Full Text Available Ambient particulate matter (PM samples were collected on quartz filters at a rural site in central Ontario during an intensive study in 2007. The concentrations of organic carbon (OC, pyrolysis organic carbon (POC, and elemental carbon (EC were determined by thermal analysis. The concentrations are compared to the organic aerosol mass concentration (OM measured with an Aerodyne C-ToF Aerosol Mass Spectrometer (AMS and to the particle absorption coefficient (basp obtained from a Radiance Research Particle Soot Absorption Photometer (PSAP. The total organic mass to organic carbon ratios (OM/OC and specific attenuation coefficients (SAC=basp/EC are derived. Proportionality of the POC mass with the oxygen mass in the aerosols estimated from the AMS offers a potential means to estimate OM/OC from thermal measurements only. The mean SAC for the study is 3.8±0.3 m2 g−1. It is found that the SAC is independent of or decrease with increasing particle mass loading, depending on whether or not the data are separated between aerosols dominated by more recent anthropogenic input and aerosols dominated by longer residence time or biogenic components. There is no evidence to support an enhancement of light absorption by the condensation of secondary material to particles, suggesting that present model simulations built on such an assumption may overestimate atmospheric warming by BC.

  14. Observations of OM/OC and specific attenuation coefficients (SAC) in ambient fine PM at a rural site in central Ontario, Canada

    Science.gov (United States)

    Chan, T. W.; Huang, L.; Leaitch, W. R.; Sharma, S.; Brook, J. R.; Slowik, J. G.; Abbatt, J. P. D.; Brickell, P. C.; Liggio, J.; Li, S.-M.; Moosmüller, H.

    2010-03-01

    Ambient particulate matter (PM) samples were collected on quartz filters at a rural site in central Ontario during an intensive study in 2007. The concentrations of organic carbon (OC), pyrolysis organic carbon (POC), and elemental carbon (EC) were determined by thermal analysis. The concentrations are compared to the organic aerosol mass concentration (OM) measured with an Aerodyne C-ToF Aerosol Mass Spectrometer (AMS) and to the particle absorption coefficient (basp) obtained from a Radiance Research Particle Soot Absorption Photometer (PSAP). The total organic mass to organic carbon ratios (OM/OC) and specific attenuation coefficients (SAC=basp/EC) are derived. Proportionality of the POC mass with the oxygen mass in the aerosols estimated from the AMS offers a potential means to estimate OM/OC from thermal measurements only. The mean SAC for the study is 3.8±0.3 m2 g-1. It is found that the SAC is independent of or decrease with increasing particle mass loading, depending on whether or not the data are separated between aerosols dominated by more recent anthropogenic input and aerosols dominated by longer residence time or biogenic components. There is no evidence to support an enhancement of light absorption by the condensation of secondary material to particles, suggesting that present model simulations built on such an assumption may overestimate atmospheric warming by BC.

  15. Effect of Graphene Nanoplatelets on Wetting, Microstructure, and Tensile Characteristics of Sn-3.0Ag-0.5Cu (SAC) Alloy

    Science.gov (United States)

    Sharma, Ashutosh; Sohn, Heung-Rak; Jung, Jae Pil

    2016-01-01

    The effect of graphene nanoplatelets (GNPs) on the wettability, microstructure, and tensile properties of Sn-3.0Ag-0.5Cu (SAC 305) was studied using melting and casting route. The microstructure of the bulk solder is observed with a scanning electron microscope and transmission electron microscope, and the intermetallic compound (IMC) phases are identified by electron probe micro-analyzer. The solderability of the samples is assessed by spreading and wetting tests on a Cu substrate. The experimental results indicate that an addition of 0.05 wt pct GNPs in Sn-3Ag-0.5Cu solder improves the spreading and wettability significantly compared to monolithic SAC. It is also revealed that the thickness of the Ag3Sn IMCs is reduced as compared to the monolithic SAC alloy. Tensile results show that the composite solder exhibits the 13.9 pct elongation and 17 pct increase in the ultimate tensile strength when 0.05 wt pct GNPs in Sn-3Ag-0.5Cu alloy are added. This may be due to the refinement of the IMCs in composite solders compared to the same in Sn-3Ag-0.5Cu alloy brought about by the uniform dispersion of graphene nanoplatelets. It is suggested in this study that the amount of GNPs in Sn-3Ag-0.5Cu alloy should not exceed 0.05 wt pct as it may degrade the desired properties due to the agglomeration of GNPs.

  16. [Ultrasound echographic imaging and measurement of the amniotic cavity and yolk sac in early pregnancy: comparative study of intact and disordered pregnancies].

    Science.gov (United States)

    Funk, A; Fendel, H

    1988-01-01

    The chorionic cavity, vertex-breech length, yolk sac, and amnion were systematically demonstrated and measured in 50 early pregnancies, i.e., between the end of the sixth and the tenth week of gestation post menstruationem (p.m.). This was done in 23 cases with clinically and sonographically intact pregnancies without symptoms of abortion, in 12 cases with living embryos with symptoms of abortion, and in 15 cases of retained miscarriage. The thin amniotic membrane is sonographically demonstrated as a narrow, sharply defined reflected band in the chorionic cavity. In addition to direct demonstration of the amniotic membrane, the amniotic cavity can be demonstrated by a density difference in the echogenicity of the chorionic and amniotic fluids. While there are delicate, homogenously distributed inner echoes in the chorionic cavity, the amniotic cavity is empty save for the embryo structure. Sonographically, therefore, the amniotic cavity stands out as a spherical structure within the chorionic cavity. In all pregnancies with a living embryo it was possible to demonstrate the yolk sac sonographically as a sharply defined ring structure in the chorionic cavity. In 10 of the 15 cases of retained miscarriage only a rudimentary remnant of the yolk sac could be detected. The development of the amniotic and chorionic cavities and vertex-breech length was constant in the pregnancies with living embryos, the amnion developing synchronously with the vertex-breech length.(ABSTRACT TRUNCATED AT 250 WORDS)

  17. The Politics, Development and Problems of Small Irrigation Dams in Malawi: Experiences from Mzuzu ADD

    Directory of Open Access Journals (Sweden)

    Bryson Gwiyani Nkhoma

    2011-10-01

    Full Text Available The paper examines the progress made regarding the development of small irrigation dams in Malawi with the view of establishing their significance in improving rural livelihoods in the country. The paper adopts a political economy theory and a qualitative research approach. Evidence from Mzuzu Agricultural Development Division (ADD, where small reservoirs acquire specific relevance, shows that despite the efforts made, the development of small dams is making little progress. The paper highlights that problems of top-down planning, high investment costs, negligence of national and local interests, over-dependency on donors, and conflicts over the use of dams – which made large-scale dams unpopular in the 1990s – continue to affect the development of small irrigation dams in Malawi. The paper argues that small irrigation dams should not be simplistically seen as a panacea to the problems of large-scale irrigation dams. Like any other projects, small dams are historically and socially constructed through interests of different actors in the local settings, and can only succeed if actors, especially those from formal institutions, develop adaptive learning towards apparent conflicting relations that develop among them in the process of implementation. In the case of Mzuzu ADD, it was the failure of the government to develop this adaptive learning to the contestations and conflicts among these actors that undermined successful implementation of small irrigation dams. The paper recommends the need to consider local circumstances, politics, interests, rights and institutions when investing in small irrigation dams.

  18. Development of a colonoscopy add-on device for improvement of the intubation process

    Directory of Open Access Journals (Sweden)

    Litten JD

    2011-12-01

    Full Text Available Jonathan D Litten1, JungHun Choi2, David Drozek31Department of Mechanical Engineering; 2Department of Mechanical Engineering and Biomedical Engineering Program; 3College of Osteopathic Medicine, Department of Specialty Medicine, Ohio University, Athens, OH, USAAbstract: A colonoscopy add-on device has been developed to reduce intubation time without modification of the current colonoscope and peripheral devices. One of the main purposes of the system is to minimize trauma caused by the distal tip of the colonoscope. The detachable sensory fixture at the end of the distal tip measures the distance between the distal tip and the colon wall in three directions, and the actuation system attached at the base of the colonoscope controls the distal tip by rotating two dial knobs. The device controls the distal tip to minimize contact between the distal tip and the colon wall, and the distal tip ideally points out the next possible lumen. A compatibility test of the infrared sensory system was carried out, and the design of the actuation system was accomplished. The system is integrated and controlled by a microprocessor. The device was tested in a silicon colon and porcine intestine. The results showed that a colonoscopist successfully reached the cecum with the aid of the colonoscopy add-on device without significant contact between the colon wall and the distal tip. The colonoscopy aid device was very helpful for the novice colonoscopist.Keywords: colonoscope, infrared sensors, intubation, trauma, colonoscopy training model

  19. Just add water: reproducible singly dispersed silver nanoparticle suspensions on-demand

    Science.gov (United States)

    MacCuspie, Robert I.; Allen, Andrew J.; Martin, Matthew N.; Hackley, Vincent A.

    2013-07-01

    Silver nanoparticles (AgNPs) are of interest due to their antimicrobial attributes, which are derived from their inherent redox instability and subsequent release of silver ions. At the same time, this instability is a substantial challenge for achieving stable long-term storage for on-demand use of AgNPs. In this study, we describe and validate a "just add water" approach for achieving suspensions of principally singly dispersed AgNPs. By lyophilizing (freeze drying) the formulated AgNPs into a solid powder, or cake, water is removed thereby eliminating solution-based chemical changes. Storing under inert gas further reduces surface reactions such as oxidation. An example of how to optimize a lyophilization formulation is presented, as well as example formulations for three AgNP core sizes. This "just add water" approach enables ease of use for the researcher desiring on-demand singly dispersed AgNP suspensions from a single master batch. Implementation of this methodology will enable studies to be performed over long periods of time and across different laboratories using particles that are identical chemically and physically and available on-demand. In addition, the approach of freeze drying and on-demand reconstitution by adding water has enabled the development of AgNP reference materials with the required shelf-life stability, one of the principal objectives of this research.

  20. Just add water: reproducible singly dispersed silver nanoparticle suspensions on-demand

    Energy Technology Data Exchange (ETDEWEB)

    MacCuspie, Robert I., E-mail: robert.maccuspie@nist.gov; Allen, Andrew J.; Martin, Matthew N.; Hackley, Vincent A. [National Institute of Standards and Technology, Materials Measurement Science Division (United States)

    2013-07-15

    Silver nanoparticles (AgNPs) are of interest due to their antimicrobial attributes, which are derived from their inherent redox instability and subsequent release of silver ions. At the same time, this instability is a substantial challenge for achieving stable long-term storage for on-demand use of AgNPs. In this study, we describe and validate a 'just add water' approach for achieving suspensions of principally singly dispersed AgNPs. By lyophilizing (freeze drying) the formulated AgNPs into a solid powder, or cake, water is removed thereby eliminating solution-based chemical changes. Storing under inert gas further reduces surface reactions such as oxidation. An example of how to optimize a lyophilization formulation is presented, as well as example formulations for three AgNP core sizes. This 'just add water' approach enables ease of use for the researcher desiring on-demand singly dispersed AgNP suspensions from a single master batch. Implementation of this methodology will enable studies to be performed over long periods of time and across different laboratories using particles that are identical chemically and physically and available on-demand. In addition, the approach of freeze drying and on-demand reconstitution by adding water has enabled the development of AgNP reference materials with the required shelf-life stability, one of the principal objectives of this research.

  1. Flexible Topology Migration in Optical Cross Add and Drop Multiplexer in Metropolitan Ring Network

    Directory of Open Access Journals (Sweden)

    Mohammad S. Ab-Rahman

    2012-01-01

    Full Text Available Problem statement: Optical Cross Add and Drop Multiplexer (OXADM is a recently invented optical networks device. Approach: A design with a purpose to combine the operational concepts of Optical Add-Drop Multiplexer (OADM and Optical Cross Connect (OXC has been developed. It is developed by studying the drawbacks in existing devices and with some excellence features added. OXADM is introduced to increase the survivability in the ring network. With the ‘Accumulation’ feature and ‘U’ turn reflection enable the multiplex, linear and ring protection scheme activated to ensure the signal arrives at the customer although breakdown occurs in the line and optical node. Beside that with the new features, the topology migration can also be done without the restructuring process due to randomly growth of new nodes. Results: The result shows that; network performance is similar without need a modification on components. Conclusion: Output power and BER performance at different node in ring and mesh optical network are shown to show the achievement of objective.

  2. CitySpace Air Sensor Network Project Conducted to Test New Monitoring Capabilities

    Science.gov (United States)

    The CitySpace project is a new research effort by EPA to field test new, lower-cost air pollution sensors in a mid-sized city to understand how this emerging technology can add valuable information on air pollution patterns in neighboorhoods.

  3. INFLUENCIA DE UN PRE-TRATAMIENTO OSMÓTICO SOBRE LA DESHIDRATACIÓN POR AIRE CALIENTE DE MANZANA GRANNY SMITH

    Directory of Open Access Journals (Sweden)

    LUIS PUENTE

    2010-01-01

    Full Text Available En este trabajo se estudió la influencia de un pretratamiento osmótico (DO a tres concentraciones (30, 40 y 50 ºBrix sobre un proceso de deshidratación de manzana por aire caliente (SAC a dos temperaturas (55 y 65 ºC. Las velocidades de deshidratación fueron mayores para las manzanas pretratadas en comparación al producto fresco, distinguiéndose una corta primera etapa de inducción solo en SAC, en ambos tipos de tratamiento (DO+SAC una imperceptible segunda etapa de velocidad constante, y una clara tercera etapa de velocidad de deshidratación decreciente I y II. La velocidad de deshidratación se modeló utilizando las ecuaciones de Newton, Page y HendersonPabis. De estos modelos el que mejor explica el proceso fue la ecuación de Page, seguida por Newton y HendersonPabis. Respecto de la temperatura, los niveles ensayados fueron significativos como factor de proceso al presentar una interacción con los pretratamientos osmóticos. La mejor condición la conformó el pretratamiento osmótico DO 50º Brix con aire caliente SAC 65 ºC.

  4. Trails, RS2477, add roads, Published in 2003, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2003. It is described as 'add roads'....

  5. Trails, RS2477, rs2477 add roads, Published in 2006, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2006. It is described as 'rs2477 add...

  6. Trails, RS2477, add roads rev, Published in 2004, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2004. It is described as 'add roads...

  7. Road and Street Centerlines, Iron add blue, Published in 2005, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — , published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2005. It is described as 'Iron add blue'. The extent of these...

  8. Trails, RS2477, add events rev, Published in 2004, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2004. It is described as 'add events...

  9. Montelukast as Add-On Therapy to Inhaled Corticosteroids in the Management of Asthma (The SAS Trial

    Directory of Open Access Journals (Sweden)

    J Mark FitzGerald

    2009-01-01

    Full Text Available AIM: To evaluate the effectiveness of montelukast as add-on therapy for asthmatic patients who remain uncontrolled with low, moderate or high doses of inhaled corticosteroid monotherapy.

  10. 鹤顶兰胚囊发育的超微结构观察%Ultrastructural Observation on Embryo Sac Development in Phaius tankervilliae (Aiton) BI.

    Institute of Scientific and Technical Information of China (English)

    李冬妹; 伍成厚; 叶秀粦; 梁承邺

    2012-01-01

    Embryo sac development in Phaius tankervilliae (Aiton) Bl. Was observed under transmission electron microscope. Three phases of functional megaspore and two phases of mature embryo sac were captured in this study. At the functional megaspore and 4-nucleate embryo sac stages, plasmodesmata were present between nucellar cells and embryo sac at the chalazal end. Plasmodesmata are cellular communicating junctions that link adjacent cells to form symplast of a plant. They provide a direct channel for material transport and signal transduction,therefore megagametogenesis is not at an absolutely insulated situation. A big vacuole was observed at the early stage of functional megaspore before it disappeared during the first mitotic division. However,many small vacuoles appeared at the interspaces of separating chromosomes. Distinct vacuoles were also observed in the synergid cells and egg cell during the early stage of mature embryo sac,but vanished when synergid cells degenerated. The change of vacuoles probably resulted from the cell physiological change. Our results may provide insights into reproductive biology of Phaius tankervilliae.%运用电子显微镜技术对鹤顶兰(Phaius tankervilliae(Aiton)BI.)胚囊发育过程中功能大孢子、二核胚囊、四核胚囊、成熟胚囊的超微结构进行观察,捕捉到了功能大孢子的三个阶段、成熟胚囊的两个阶段,进一步积累了鹤顶兰生殖生物学研究的基础资料.在功能大孢子、四核胚囊时期的合点端壁上可观察到胞间连丝,与体细胞间有物质及信息的交换,胚囊发育并非处于完全“隔离”状态.功能大孢子早期可见明显大液泡,随后进入第一次有丝分裂时大液泡消失,移向两极的染色体之间可见大量体积较小的液泡,成熟胚囊前期助细胞及卵细胞内也可见明显液泡,但当助细胞解体时,卵细胞内的大液泡也消失,液泡形态的变化可能是细胞生理状态发生改变的结果.

  11. Experimental re-evaluation of flunarizine as add-on antiepileptic therapy

    Science.gov (United States)

    Thakur, Anamika; Sahai, A. K.; Thakur, J. S.

    2011-01-01

    Background: Experimental studies have found several calcium channel blockers with anticonvulsant property. Flunarizine is one of the most potent calcium channel blockers, which has shown anticonvulsant effect against pentylenetetrazole (PTZ) and maximal electroshock (MES)-induced seizures. However, further experimental and clinical trials have shown varied results. We conducted a PTZ model experimental study to re-evaluate the potential of flunarizine for add-on therapy in the management of refractory epilepsy. Materials and Methods: Experiments were conducted in PTZ model involving Swiss strain mice. Doses producing seizures in 50% and 99% mice, i.e. CD50 and CD99 values of PTZ were obtained from the dose-response study. Animals received graded, single dose of sodium valproate (100–300 mg/kg), lamotrigine (3–12 mg/kg) and flunarizine (5–20 mg/kg), and then each group of mice was injected with CD99 dose of PTZ (65mg/kg i.p.). Another group of mice received single ED50 dose (dose producing seizure protection in 50% mice) of sodium valproate and flunarizine separately in left and right side of abdomen. Results were analysed by Kruskal–Wallis ANOVA on Ranks test. Results: As compared to control, sodium valproate at 250 mg/kg and 300 mg/kg produced statistical significant seizure protection. At none of the pre-treatment dose levels of lamotrigine, the seizure score with PTZ differed significantly from that observed in the vehicle-treated group. Pre-treatment with flunarizine demonstrated dose-dependent decrease in the seizure score to PTZ administration. As compared to control group, flunarizine at 20 mg/kg produced statistical significant seizure protection. Conclusion: As combined use of sodium valproate and flunarizine has shown significant seizure protection in PTZ model, flunarizine has a potential for add-on therapy in refractory cases of partial seizures. It is therefore, we conclude that further experimental studies and multicenter clinical trials

  12. Experimental re-evaluation of flunarizine as add-on antiepileptic therapy

    Directory of Open Access Journals (Sweden)

    Anamika Thakur

    2011-01-01

    Full Text Available Background: Experimental studies have found several calcium channel blockers with anticonvulsant property. Flunarizine is one of the most potent calcium channel blockers, which has shown anticonvulsant effect against pentylenetetrazole (PTZ and maximal electroshock (MES-induced seizures. However, further experimental and clinical trials have shown varied results. We conducted a PTZ model experimental study to re-evaluate the potential of flunarizine for add-on therapy in the management of refractory epilepsy. Materials and Methods: Experiments were conducted in PTZ model involving Swiss strain mice. Doses producing seizures in 50% and 99% mice, i.e. CD 50 and CD 99 values of PTZ were obtained from the dose-response study. Animals received graded, single dose of sodium valproate (100-300 mg/kg, lamotrigine (3-12 mg/kg and flunarizine (5-20 mg/kg, and then each group of mice was injected with CD 99 dose of PTZ (65mg/kg i.p.. Another group of mice received single ED 50 dose (dose producing seizure protection in 50% mice of sodium valproate and flunarizine separately in left and right side of abdomen. Results were analysed by Kruskal-Wallis ANOVA on Ranks test. Results: As compared to control, sodium valproate at 250 mg/kg and 300 mg/kg produced statistical significant seizure protection. At none of the pre-treatment dose levels of lamotrigine, the seizure score with PTZ differed significantly from that observed in the vehicle-treated group. Pre-treatment with flunarizine demonstrated dose-dependent decrease in the seizure score to PTZ administration. As compared to control group, flunarizine at 20 mg/kg produced statistical significant seizure protection. Conclusion: As combined use of sodium valproate and flunarizine has shown significant seizure protection in PTZ model, flunarizine has a potential for add-on therapy in refractory cases of partial seizures. It is therefore, we conclude that further experimental studies and multicenter clinical

  13. Introduction to SAC

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Standardization Administration of the People's Republic of China was established by the State Council of China in April 2001 and authorized by the State Council to exercise the administrative functions and carry out centralized administration for standardization in China.

  14. Fabrication and comprehensive modeling of ion-exchanged Bragg optical add-drop multiplexers.

    Science.gov (United States)

    Castro, Jose M; Geraghty, David F; West, Brian R; Honkanen, Seppo

    2004-11-20

    Optical add-drop multiplexers (OADMs) based on asymmetric Y branches and tilted gratings offer excellent-performance in wavelength-division multiplexed systems. To simplify waveguide fabrication, ion-exchange techniques appear to be an important option in photosensitive glasses. Optimum OADM performance depends on how accurately the waveguide fabrication process and tilted Bragg grating operation are understood and modeled. Results from fabrication and comprehensive modeling are compared for ion-exchange processes that use different angles of the tilted grating. The transmission and reflection spectra for the fabricated and simulated OADMs show excellent agreement. The OADM's performance is evaluated in terms of the measured characteristics of the Y branches and tilted gratings.

  15. SCEW: a Microsoft Excel add-in for easy creation of survival curves.

    Science.gov (United States)

    Khan, Haseeb Ahmad

    2006-07-01

    Survival curves are frequently used for reporting survival or mortality outcomes of experimental pharmacological/toxicological studies and of clinical trials. Microsoft Excel is a simple and widely used tool for creation of numerous types of graphic presentations however it is difficult to create step-wise survival curves in Excel. Considering the familiarity of clinicians and biomedical scientists with Excel, an algorithm survival curves in Excel worksheet (SCEW) has been developed for easy creation of survival curves directly in Excel worksheets. The algorithm has been integrated in the form of Excel add-in for easy installation and usage. The program is based on modification of frequency data for binary break-up using the spreadsheet formula functions whereas a macro subroutine automates the creation of survival curves. The advantages of this program are simple data input, minimal procedural steps and the creation of survival curves in the familiar confines of Excel.

  16. Application of shift-and-add algorithms for imaging objects within biological media

    Science.gov (United States)

    Aizert, Avishai; Moshe, Tomer; Abookasis, David

    2017-01-01

    The Shift-and-Add (SAA) technique is a simple mathematical operation developed to reconstruct, at high spatial resolution, atmospherically degraded solar images obtained from stellar speckle interferometry systems. This method shifts and assembles individual degraded short-exposure images into a single average image with significantly improved contrast and detail. Since the inhomogeneous refractive indices of biological tissue causes light scattering similar to that induced by optical turbulence in the atmospheric layers, we assume that SAA methods can be successfully implemented to reconstruct the image of an object within a scattering biological medium. To test this hypothesis, five SAA algorithms were evaluated for reconstructing images acquired from multiple viewpoints. After successfully retrieving the hidden object's shape, quantitative image quality metrics were derived, enabling comparison of imaging error across a spectrum of layer thicknesses, demonstrating the relative efficacy of each SAA algorithm for biological imaging.

  17. Interaction and dynamics of add-atoms with 2-dimensional structures

    CERN Multimedia

    The interaction and dynamics of add-atoms with graphene, graphene-derivate structures and, later, MoSi$_2$, two-dimensional – single and few – atomic layers will be studied with the Perturbed Angular Correlation – PAC – technique. Graphene is also envisaged as new platform for growing semiconductor nanostructure devices, such as quantum dots and as a particularly powerful catalyst. Understanding nucleation of nanostructures and clusters on graphene and related phases in wet conditions as they are used in chemical methods in research and industry require complementary studies. These systems will therefore be studied systematically using radioactive probe atoms attaching via a transfer media (e.g., water in catalysis process) or being deposited with soft-landing techniques under vacuum and UHV conditions, as put in place at the ASPIC setup at ISOLDE. The hyperfine fields obtained under different environments are expected to reveal basic information on the rich atomic and physical mechanisms associated w...

  18. Sliding tethered ligands add topological interactions to the toolbox of ligand-receptor design

    Science.gov (United States)

    Bauer, Martin; Kékicheff, Patrick; Iss, Jean; Fajolles, Christophe; Charitat, Thierry; Daillant, Jean; Marques, Carlos M.

    2015-09-01

    Adhesion in the biological realm is mediated by specific lock-and-key interactions between ligand-receptor pairs. These complementary moieties are ubiquitously anchored to substrates by tethers that control the interaction range and the mobility of the ligands and receptors, thus tuning the kinetics and strength of the binding events. Here we add sliding anchoring to the toolbox of ligand-receptor design by developing a family of tethered ligands for which the spacer can slide at the anchoring point. Our results show that this additional sliding degree of freedom changes the nature of the adhesive contact by extending the spatial range over which binding may sustain a significant force. By introducing sliding tethered ligands with self-regulating length, this work paves the way for the development of versatile and reusable bio-adhesive substrates with potential applications for drug delivery and tissue engineering.

  19. What Can Heterogeneity Add to the Scientometric Map? Steps towards algorithmic historiography

    CERN Document Server

    Leydesdorff, Loet

    2010-01-01

    The Actor Network represents heterogeneous entities as actants (Callon et al., 1983; 1986). Although computer programs for the visualization of social networks increasingly allow us to represent heterogeneity in a network using different shapes and colors for the visualization, hitherto this possibility has scarcely been exploited (Mogoutov et al., 2008). In this contribution to the Festschrift, I study the question of what heterogeneity can add specifically to the visualization of a network. How does an integrated network improve on the one-dimensional ones (such as co-word and co-author maps)? The oeuvre of Michel Callon is used as the case materials, that is, his 65 papers which can be retrieved from the (Social) Science Citation Index since 1975.

  20. Circadian rest-activity rhythms during benzodiazepine tapering covered by melatonin versus placebo add-on

    DEFF Research Database (Denmark)

    Baandrup, Lone; Fasmer, Ole Bernt; Glenthøj, Birte Yding

    2016-01-01

    BACKGROUND: Patients with severe mental illness often suffer from disruptions in circadian rest-activity cycles, which might partly be attributed to ongoing psychopharmacological medication. Benzodiazepines are frequently prescribed for prolonged periods despite recommendations of only short......-term usage. Melatonin, a naturally occurring nocturnal hormone, has the potential to stabilize disrupted circadian rhythmicity. Our aim was to investigate how prolonged-release melatonin affects rest-activity patterns in medicated patients with severe mental illness and if benzodiazepine dose reduction...... is associated with changes in circadian rhythm parameters. METHOD: Data were derived from a randomized, double-blinded clinical trial with 24 weeks follow-up. Participants were randomized to add-on treatment with prolonged-release melatonin (2 mg) or matching placebo, and usual benzodiazepine dosage...

  1. Biosynthesis of Succulent Bamboo Shoots of Bambusa balcooa into Phytosterols and Its Biotransformation into ADD

    Institute of Scientific and Technical Information of China (English)

    Kananbala SARANGTHEM; Thongam Nabakumar SINGH

    2003-01-01

    Fermentation of the succulent bamboo shoots of Bambusa balcooa Roxb. resulted in an enrichment of phytosterols from 0.12% to 0.62% dry weight as compared to that of the fresh unfermented samples. The bacterial strains responsible for higher accumulation of phytosterols during fermentation of the bamboo shoots have been isolated and further extraction and purification of the crude phytosterols (isolated from the fermented samples) were done by TLC, UV, NMR, IR and Mass spectral analysis. The isolated phytosterols (β-sitos-terols) were then subjected to microbial transformation which yielded a considerable amount of androsta-1, 4-diene-3,17-dione (ADD) in the incubation mixture in presence of metabolic inhibitors (α, α'-dipyridyl and sodium arsenate).

  2. Neurofeedback combined with training in metacognitive strategies: effectiveness in students with ADD.

    Science.gov (United States)

    Thompson, L; Thompson, M

    1998-12-01

    A review of records was carried out to examine the results obtained when people with Attention Deficit Disorder (ADD) received 40 sessions of training that combined neurofeedback with the teaching of metacognitive strategies. While not a controlled scientific study, the results, including pre- and post-measures, are consistent with previously published research concerning the use of neurofeedback with children. A significant addition is that a description of procedures is included. The 111 subjects, 98 children (age 5 to 17) and 13 adults (ages 18 to 63), attended forty 50-min sessions, usually twice a week. Feedback was contingent on decreasing slow wave activity (usually 4-7 Hz, occasionally 9-11 Hz) and increasing fast wave activity (15-18 Hz for most subjects but initially 13-15 Hz for subjects with impulsivity and hyperactivity). Metacognitive strategies related to academic tasks were taught when the feedback indicated the client was focused. Some clients also received temperature and/or EDR biofeedback during some sessions. Initially, 30 percent of the children were taking stimulant medications (Ritalin), whereas 6 percent were on stimulant medications after 40 sessions. All charts were included where pre- and post-testing results were available for one or more of the following: the Test of Variables of Attention (TOVA, n = 76), Wechsler Intelligence Scales (WISC-R, WISC-III, or WAIS-R, n = 68), Wide Range Achievement Test (WRAT 3, n = 99), and the electroencephalogram assessment (QEEG) providing a ratio of theta (4-8 Hz) to beta (16-20 Hz) activity (n = 66). Significant improvements (p metacognitive strategies is a useful combined intervention for students with ADD. Further controlled research is warranted.

  3. Review on SOA-MZl-based photonic add/drop and switching operations

    Institute of Scientific and Technical Information of China (English)

    Claudio PORZI; Giovanni SERAFINO; Sergio PINNA; An NGUYEN; Giampiero CONTESTABILE; Antonclla BOGONI

    2013-01-01

    Semiconductor optical amplifier-Mach-Zehnder interferometer (SOA-MZI) is a technologically mature optical device that can be exploited for a wide range of operations on both amplitude and phase modulated signals, with performance limited by the carrier lifetime in the SOAs. Recent advances on SOA structures have demonstrated their suitability for high quality, ultra-fast photonic signal processing, making SOA-MZI a good candidate for elaborating signals in new generation high-capacity optical networks. Dynamic wavelength switching/routing and add/drop operations are expected to bring benefits in future optical networks in terms of improved system flexibility and efficiency. The capability of performing such operations directly in the optical domain can significantly reduce the number of opto/electrical and electro/optical conversions in the routing nodes, reducing their power consumption and their latency time. Moreover, since phase-shift keying (PSK) formats or other advanced modulation formats involving both amplitude and phase modulation, start to coexist in optical communication systems with the conventional on-off keying (OOK) modulation format, the availability of a single device, suitable for processing all these different signals, is mandatory. The SOA-MZI fits all these requirements for both OOK and constant-envelope phase-modulated signals, providing a compact and flexible solution. Here we review on the use of the SOA-MZI for carrying out all- optical switching operations, by realizing wavelength conversion and add/drop functionalities, both for OOK and differential binary phase shift keying (DPSK) signals up to 40Gb/s. Power penalties lower than 2 dB are demonstrated in all cases.

  4. 40 CFR 63.4966 - How do I establish the emission capture system and add-on control device operating limits during...

    Science.gov (United States)

    2010-07-01

    ... system and add-on control device operating limits during the performance test? 63.4966 Section 63.4966... outlet gas temperature is the maximum operating limit for your condenser. (e) Emission capture system... with Add-on Controls Option § 63.4966 How do I establish the emission capture system and add-on...

  5. 40 CFR 63.3546 - How do I establish the emission capture system and add-on control device operating limits during...

    Science.gov (United States)

    2010-07-01

    ... system and add-on control device operating limits during the performance test? 63.3546 Section 63.3546... device or system of multiple capture devices. The average duct static pressure is the maximum operating... Add-on Controls Option § 63.3546 How do I establish the emission capture system and add-on...

  6. 40 CFR 63.4567 - How do I establish the emission capture system and add-on control device operating limits during...

    Science.gov (United States)

    2010-07-01

    ... system and add-on control device operating limits during the performance test? 63.4567 Section 63.4567... Emission Rate with Add-on Controls Option § 63.4567 How do I establish the emission capture system and add-on control device operating limits during the performance test? During the performance test...

  7. 40 CFR 63.4167 - How do I establish the emission capture system and add-on control device operating limits during...

    Science.gov (United States)

    2010-07-01

    ... system and add-on control device operating limits during the performance test? 63.4167 Section 63.4167... with Add-on Controls Option § 63.4167 How do I establish the emission capture system and add-on control device operating limits during the performance test? During the performance test required by §...

  8. 40 CFR 63.4767 - How do I establish the emission capture system and add-on control device operating limits during...

    Science.gov (United States)

    2010-07-01

    ... system and add-on control device operating limits during the performance test? 63.4767 Section 63.4767... Rate with Add-on Controls Option § 63.4767 How do I establish the emission capture system and add-on control device operating limits during the performance test? During the performance test required by §...

  9. Back to the Future: Integrated Air and Missile Defense in the Pacific

    Science.gov (United States)

    2015-02-01

    Add to those the Aegis system, ground-based air defense, and short-ranged air defense to destroy an adversary’s inbound air threats. By combining...Technology Demonstra- tion. Designed to protect critical, vulnerable assets through the most cost -effective application of hardening/ resiliency methods...ability to /( flush-launch" (rapid engine start, taxi, and takeoff) alert aircraft upon receipt of warnings of tactical inbound missiles and

  10. Air Pollution

    Science.gov (United States)

    ... to view this content or go to source URL . What NIEHS is Doing on Air Pollution Who ... Junction Last Reviewed: February 06, 2017 This page URL: NIEHS website: https://www.niehs.nih.gov/ Email ...

  11. Notice on the 3 National Compulsory Standards Stipulated by AQSIQ and SAC,including the General Technical Regulations for Infant Blended Milk Powder and Infant Complete Grain Flour

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ In order to meet the needs of the current milk powder market and to lead enterprises to abide by the 3 national compulsory standards, i.e., the General Technical Regulations for Infant Blended Milk Powder and Infant Completed Grain Flour,GB10767-1997, the Infant Blended Milk Powder I(Blended Power Ⅰ), GB10765-1997 and the Infant Blended Milk Powder Ⅱ and Ⅲ (Blended Power Ⅱ and Ⅲ), GB10766-1997, General Administration of Quality Supervision, Inspection and Quarantine of China (AQSIQ) and Standardization Administration of China (SAC) issued the following notice, explaining requirements in detail.

  12. Comparative study on the quality of different citrus juice sacs%不同品种柑橘汁胞的品质比较研究

    Institute of Scientific and Technical Information of China (English)

    杨子玉; 唐颂; 任婧楠; 台亚楠; 董曼; 潘思轶; 范刚

    2015-01-01

    汁胞是柑橘汁胞饮料中重要的组成部分,其品质决定了柑橘汁胞饮料的色泽、口感等一系列感官指标.本文以夏橙、赣南脐橙、温州蜜柑和湘西椪柑四种柑橘作为研究对象,比较了四种不同柑橘汁胞可溶性固形物含量、可滴定酸、汁胞柄长度、色度等理化指标的差异,并对不同品种的柑橘汁胞进行了感官评定,综合二者进行评价.结果表明,四个不同品种柑橘汁胞中VC含量在20~45 mg/1 00mL之间,其中赣南脐橙的VC含量最高,湘西椪柑可溶性固形物含量最高;除湘西椪柑与赣南脐橙之外,四个品种两两之间色度差异较大;感官分析结果表明湘西椪柑汁胞具有最良好的感官特征.%Citrus juice sacs are important portion of the citrus juice sacs drink,its quality determines series of sensory index of the citrus juice sacs drink.Valencia Orange,Gannan navel orange,Satsuma orange and Xiangxi ponkan were selected as research materials,the physicochemical indexes of these four cultivars were determined,and sensory evaluation was also investigated.The results showed that the VC contents were 20~45mg/100mL of these citrus juice sacs,and the highest level of VC in Gannan navel orange was observed.The content of soluble solid in Xiangxi ponkan was the highest among these citrus cultivars.A great difference on the color was observed beween the two cultivars except for Xiangxi ponkan and Gannan navel orange.The sensory evaluation results showed that Xiangxi ponkan had the best sensory attribute.

  13. Add-on conservation benefits of marine territorial user rights fishery policies in central Chile.

    Science.gov (United States)

    Gelcich, Stefan; Godoy, Natalio; Prado, Luis; Castilla, Juan Carlos

    2008-01-01

    To combine the rational use of marine benthic resources and economic development of small-scale fishers, Chile passed legislation in 1991 establishing a comanagement policy that grants exclusive territorial user rights for fisheries (TURFs) to artisanal fisher organizations in well-defined inshore coastal areas, known as Management and Exploitation Areas for Benthic Resources (MEABRs). In general the policy has been proclaimed a management and economic success because benthic resource abundances have increased inside MEABRs in comparison with open-access areas. However, there is a lack of studies assessing the impact of this management policy on nontargeted subtidal species and community assemblages and the policy's implications for biodiversity and conservation. This study starts to fill this gap and links the allocation of TURFs for benthic resources with add-on conservation benefits for species that are not directly linked with the fishery policy. Comparative subtidal surveys inside vs. outside MEABRs were used to assess the effects of three MEABRs on managed targeted benthic species, biodiversity (species richness), and community assemblages in central Chile. Surveys focused exclusively on subtidal kelp forest habitats dominated by Lessonia trabeculata, spanning 4-12 m in depth and with similar levels of habitat complexity. The study comprised: (1) quantification of kelp forest complexity, (2) understory survey of sessile species, (3) quantification of conspicuous benthic macroinvertebrates, including those under management, and (4) quantification of reef-fish species inside the kelp habitat. Results showed population enhancement of target-managed invertebrates inside MEABRs. Moreover, reef-fish species were significantly more diverse and abundant inside MEABRs, and community assemblages of nontarget benthic invertebrates and reef fish were significantly different inside vs. outside MEABRs. The comanagement of inshore benthic resources in Chile, through MEABRs

  14. Can your air-cooled condenser handle the big chill?

    Energy Technology Data Exchange (ETDEWEB)

    Larinoff, M.W.

    1997-01-01

    The two-stage air-cooled condenser (ACC) is less vulnerable to freezeup than the single-stage. But not surprisingly, the greater freeze-protection margin typically costs more. External freeze-protection devices--such as warm-air recirculation systems and airflow control louvers--can mitigate the single-stage design`s vulnerability, although these add to costs, too. Air-cooled condensers have become popular to conserve water, abate plumes, and ease other environmental concerns. This article discusses the critical differences in freeze-protection design features.

  15. Novel broadband reconfigurable optical add-drop multiplexer employing custom fiber arrays and Opto-VLSI processors.

    Science.gov (United States)

    Xiao, Feng; Juswardy, Budi; Alameh, Kamal; Lee, Yong Tak

    2008-08-04

    A reconfigurable optical add/drop multiplexer (ROADM) structure based on using a custom-made fiber array and an Opto-VLSI processor is proposed and demonstrated. The fiber array consists of N pairs of angled fibers corresponding to N channels, each of which can independently perform add, drop, and thru functions through a reconfigurable Opto-VLSI beam steerer. Experimental results show that the ROADM structure can attain an average add, drop/thru insertion loss of 5.5 dB and a uniformity of 0.3 dB over a wide bandwidth from 1524 nm to 1576 nm, and a drop/thru crosstalk level as small as -40 dB.

  16. A multiply-add engine with monolithically integrated 3D memristor crossbar/CMOS hybrid circuit

    Science.gov (United States)

    Chakrabarti, B.; Lastras-Montaño, M. A.; Adam, G.; Prezioso, M.; Hoskins, B.; Cheng, K.-T.; Strukov, D. B.

    2017-02-01

    Silicon (Si) based complementary metal-oxide semiconductor (CMOS) technology has been the driving force of the information-technology revolution. However, scaling of CMOS technology as per Moore’s law has reached a serious bottleneck. Among the emerging technologies memristive devices can be promising for both memory as well as computing applications. Hybrid CMOS/memristor circuits with CMOL (CMOS + “Molecular”) architecture have been proposed to combine the extremely high density of the memristive devices with the robustness of CMOS technology, leading to terabit-scale memory and extremely efficient computing paradigm. In this work, we demonstrate a hybrid 3D CMOL circuit with 2 layers of memristive crossbars monolithically integrated on a pre-fabricated CMOS substrate. The integrated crossbars can be fully operated through the underlying CMOS circuitry. The memristive devices in both layers exhibit analog switching behavior with controlled tunability and stable multi-level operation. We perform dot-product operations with the 2D and 3D memristive crossbars to demonstrate the applicability of such 3D CMOL hybrid circuits as a multiply-add engine. To the best of our knowledge this is the first demonstration of a functional 3D CMOL hybrid circuit.

  17. How to Add Value to your Business with CEA: A Practical Approach

    Directory of Open Access Journals (Sweden)

    Daniel Cardenas

    2010-04-01

    Full Text Available Companies are always trying to differentiate themselves from the rest of the pack by applying different strategies such as improving customer service, increasing the efficiency of their operations, or reducing their costs. Most of the time, however, these goals are competing against each other for scarce resources, and managers often need to decide to concentrate on one. A small company can effectively and simultaneously accomplish these goals for a fraction of the cost by implementing communications-enabled business processes or solutions, which are a set of technology components that add real-time networking functionality to applications. One particular implementation of this framework is the one provided by Coral CEA. Coral CEA is a business ecosystem anchored around CEA functionalities that are offered as building blocks, out-of-the-box components that link the capabilities and intelligence of networks platforms with the power of current applications to provide a new set of features and functionalities. In this article, we show how a small company called Rezact, located in the ski resort town of Mont-Tremblant, Quebec, successfully implemented CEA capabilities within its own operations using Coral CEA services.

  18. A multiply-add engine with monolithically integrated 3D memristor crossbar/CMOS hybrid circuit

    Science.gov (United States)

    Chakrabarti, B.; Lastras-Montaño, M. A.; Adam, G.; Prezioso, M.; Hoskins, B.; Cheng, K.-T.; Strukov, D. B.

    2017-01-01

    Silicon (Si) based complementary metal-oxide semiconductor (CMOS) technology has been the driving force of the information-technology revolution. However, scaling of CMOS technology as per Moore’s law has reached a serious bottleneck. Among the emerging technologies memristive devices can be promising for both memory as well as computing applications. Hybrid CMOS/memristor circuits with CMOL (CMOS + “Molecular”) architecture have been proposed to combine the extremely high density of the memristive devices with the robustness of CMOS technology, leading to terabit-scale memory and extremely efficient computing paradigm. In this work, we demonstrate a hybrid 3D CMOL circuit with 2 layers of memristive crossbars monolithically integrated on a pre-fabricated CMOS substrate. The integrated crossbars can be fully operated through the underlying CMOS circuitry. The memristive devices in both layers exhibit analog switching behavior with controlled tunability and stable multi-level operation. We perform dot-product operations with the 2D and 3D memristive crossbars to demonstrate the applicability of such 3D CMOL hybrid circuits as a multiply-add engine. To the best of our knowledge this is the first demonstration of a functional 3D CMOL hybrid circuit. PMID:28195239

  19. How social learning adds up to a culture: from birdsong to human public opinion.

    Science.gov (United States)

    Tchernichovski, Ofer; Feher, Olga; Fimiarz, Daniel; Conley, Dalton

    2017-01-01

    Distributed social learning may occur at many temporal and spatial scales, but it rarely adds up to a stable culture. Cultures vary in stability and diversity (polymorphism), ranging from chaotic or drifting cultures, through cumulative polymorphic cultures, to stable monolithic cultures with high conformity levels. What features can sustain polymorphism, preventing cultures from collapsing into either chaotic or highly conforming states? We investigate this question by integrating studies across two quite separate disciplines: the emergence of song cultures in birds, and the spread of public opinion and social conventions in humans. In songbirds, the learning process has been studied in great detail, while in human studies the structure of social networks has been experimentally manipulated on large scales. In both cases, the manner in which communication signals are compressed and filtered - either during learning or while traveling through the social network - can affect culture polymorphism and stability. We suggest a simple mechanism of a shifting balance between converging and diverging social forces to explain these effects. Understanding social forces that shape cultural evolution might be useful for designing agile communication systems, which are stable and polymorphic enough to promote gradual changes in institutional behavior.

  20. Predictors of life satisfaction among Asian American adolescents- analysis of add health data.

    Science.gov (United States)

    Huang, Jui-Yen; Wang, Kuan-Yuan; Ringel-Kulka, Tamar

    2015-01-01

    Life satisfaction correlates with adolescent risk taking behavior and their outcomes in adulthood. Despite the fast rise in numbers of Asian adolescents in the U.S., the predictors of their life satisfaction are not well understood. This study examined the relationship between several demographic and contextual factors and global life satisfaction among this population. Data were derived from the National Longitudinal Study of Adolescent Health (Add Health), a nationally representative probability sample of US adolescents. Bivariate and multivariable logistic regression was conducted to evaluate hypothesized predictors of global life satisfaction of Asian American adolescents. All analyses were conducted using STATA version 11. After exclusion of cases with missing values, 1021 Asian American adolescents were studied. Self- rated health, self-esteem, perceived neighborhood quality, parental support and peer support were significantly and positively related to better global life satisfaction. However, after controlling for other factors, only self-esteem (adjusted odds ratio [aOR]: 4.76; 95% confidence interval [CI]: 2.86-8.33) and perceived peer support (aOR: 2.76; 95% CI: 1.33-5.76) significantly predicted higher life satisfaction. Peer support and adolescents' self-concept are strongly correlated with Asian American adolescents' subjective well-being. To promote the wellness of this population, culturally sensitive strategies in developing peer relationship and healthy self-concept may be effective. More studies are needed for subgroup comparison of various ethnicities among Asian American adolescents.

  1. CosmoCalc: An Excel add-in for cosmogenic nuclide calculations

    Science.gov (United States)

    Vermeesch, Pieter

    2007-08-01

    As dating methods using Terrestrial Cosmogenic Nuclides (TCN) become more popular, the need arises for a general-purpose and easy-to-use data reduction software. The CosmoCalc Excel add-in calculates TCN production rate scaling factors (using Lal, Stone, Dunai, and Desilets methods); topographic, snow, and self-shielding factors; and exposure ages, erosion rates, and burial ages and visualizes the results on banana-style plots. It uses an internally consistent TCN production equation that is based on the quadruple exponential approach of Granger and Smith (2000). CosmoCalc was designed to be as user-friendly as possible. Although the user interface is extremely simple, the program is also very flexible, and nearly all default parameter values can be changed. To facilitate the comparison of different scaling factors, a set of converter tools is provided, allowing the user to easily convert cut-off rigidities to magnetic inclinations, elevations to atmospheric depths, and so forth. Because it is important to use a consistent set of scaling factors for the sample measurements and the production rate calibration sites, CosmoCalc defines the production rates implicitly, as a function of the original TCN concentrations of the calibration site. The program is best suited for 10Be, 26Al, 3He, and 21Ne calculations, although basic functionality for 36Cl and 14C is also provided. CosmoCalc can be downloaded along with a set of test data from http://cosmocalc.googlepages.com.

  2. PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel.

    Science.gov (United States)

    Zhang, Yong; Huo, Meirong; Zhou, Jianping; Xie, Shaofei

    2010-09-01

    This study presents PKSolver, a freely available menu-driven add-in program for Microsoft Excel written in Visual Basic for Applications (VBA), for solving basic problems in pharmacokinetic (PK) and pharmacodynamic (PD) data analysis. The program provides a range of modules for PK and PD analysis including noncompartmental analysis (NCA), compartmental analysis (CA), and pharmacodynamic modeling. Two special built-in modules, multiple absorption sites (MAS) and enterohepatic circulation (EHC), were developed for fitting the double-peak concentration-time profile based on the classical one-compartment model. In addition, twenty frequently used pharmacokinetic functions were encoded as a macro and can be directly accessed in an Excel spreadsheet. To evaluate the program, a detailed comparison of modeling PK data using PKSolver and professional PK/PD software package WinNonlin and Scientist was performed. The results showed that the parameters estimated with PKSolver were satisfactory. In conclusion, the PKSolver simplified the PK and PD data analysis process and its output could be generated in Microsoft Word in the form of an integrated report. The program provides pharmacokinetic researchers with a fast and easy-to-use tool for routine and basic PK and PD data analysis with a more user-friendly interface.

  3. Mozart K.448 acts as a potential add-on therapy in children with refractory epilepsy.

    Science.gov (United States)

    Lin, Lung-Chang; Lee, Wei-Te; Wang, Chien-Hua; Chen, Hsiu-Lin; Wu, Hui-Chuan; Tsai, Chin-Lin; Wei, Ruey-Chang; Mok, Hin-Kiu; Weng, Chia-Fen; Lee, Mei-Wen; Yang, Rei-Cheng

    2011-03-01

    Mozart's Sonata for two pianos in D major, K.448 (Mozart K.448), has been shown to improve mental function, leading to what is known as the Mozart effect. Our previous work revealed that epileptiform discharges in children with epilepsy decreased during and immediately after listening to Mozart K.448. In this study, we evaluated the long-term effects of Mozart K.448 on children with refractory epilepsy. Eleven children with refractory epilepsy were enrolled. All of the patients were diagnosed as having had refractory epilepsy for more than 1 year (range =1 year to 6 years 4 months, mean =3 years 11 months) and had been receiving at least two antiepileptic drugs (AED). During the study period, they listened to Mozart K.448 once a day before bedtime for 6 months. Seizure frequencies were recorded 6 months before they started listening to this music and monthly during the study period. All of the patients remained on the same AEDs during the 6-month study period. Frequencies of seizures were compared before and after listening to Mozart K.448. Eight of eleven patients were seizure free (N=2) or had very good responses (N=6) after 6 months of listening to Mozart K.448. The remaining three (27.3%) showed minimal or no effect (effectiveness Mozart K.448 should be further studied as a potential add-on therapy in the treatment of children with refractory epilepsy.

  4. Clobazam: An effective add-on therapy in refractory status epilepticus.

    Science.gov (United States)

    Sivakumar, Sanjeev; Ibrahim, Mohammad; Parker, Dennis; Norris, Gregory; Shah, Aashit; Mohamed, Wazim

    2015-06-01

    Refractory status epilepticus (RSE) is a medical emergency, with significant morbidity and mortality. The use and effectiveness of clobazam, a unique 1,5-benzodiazepine, in the management of RSE has not been reported before. Over the last 24 months, we identified 17 patients with RSE who were treated with clobazam in our hospital. Eleven of the 17 patients had prior epilepsy. Fifteen patients had focal status epilepticus. Use of clobazam was prompted by a favorable pharmacokinetic profile devoid of drug interactions. Clobazam was introduced after a median duration of 4 days and after a median of three failed antiepileptic drugs. A successful response, defined as termination of RSE within 24 h of administration, without addition or modification of concurrent AED and with successful wean of anesthetic infusions, was seen in 13 patients. Indeterminate response was seen in three patients, whereas clobazam was unsuccessful in one patient. Clobazam averted the need for anesthetic infusions in five patients. Clobazam was well tolerated, and appears to be an effective and promising option as add-on therapy in RSE. Its efficacy, particularly early in the course of SE, should be further investigated in prospective, randomized trials.

  5. Effectiveness of clobazam as add-on therapy in children with refractory focal epilepsy.

    Science.gov (United States)

    da Silveira, Mariana Ribeiro Marcondes; Montenegro, Maria Augusta; Franzon, Renata Cristina; Guerreiro, Carlos A M; Guerreiro, Marilisa M

    2006-09-01

    The objective of this study was to evaluate the safety and efficacy of clobazam in children with refractory focal epilepsy. We investigated 100 consecutive patients concerning etiology of epilepsy, previously used antiepileptic drugs, seizure frequency and adverse events. Clobazam was introduced as add-on therapy in patients with previous failure of at least two monotherapies. Mean age was eight years-old and 39 patients were girls. Clobazam mean dosage was 23.6 mg/day. Mean use of clobazam was 18.6 months. Twenty-two patients had adverse events. Twenty-six patients became seizure-free, 11 had an improvement of >75% and in 58 there was no modification in seizure frequency. Five patients had an increase in seizure frequency. Clobazam efficacy lasted for more than one year in 42% of the seizure-free patients. Clobazam seems to be safe and effective in the treatment of focal epilepsy in childhood and should be considered in patients with refractory seizures.

  6. Calling all LEGO lovers! Add a mini control room to your collection

    CERN Multimedia

    Katarina Anthony

    2015-01-01

    The mini LHC Lego project launched in March (see here) now has almost 6,000 supporters - well on its way to the 10,000 votes needed for it to (hopefully!) hit store shelves. This week, the project added a new feature to its line: a mini control centre! The new LEGO Control centre, featuring operators "Kerstin" and "Marco".   The mini LHC project is the brainchild of ATLAS PhD student Nathan Readioff, who designed Lego replicas of the LHC and the ALICE, ATLAS, CMS and LHCb experiments on a micro scale. Each detector model is small enough to fit in the palm of your hand but crammed with detailed internal systems revealed by cutaway walls. Every major detector component is represented by a Lego piece. Now, Nathan has created a control centre to complement the mini LHC project. This would be an add-on feature for Lego’s consideration, should they decide to develop the accelerator into a box set. “The control centre is ...

  7. triADD: the risk for alcohol abuse, depression, and diabetes multimorbidity in the American Indian and Alaska Native populations.

    Science.gov (United States)

    Tann, Sheila S; Yabiku, Scott T; Okamoto, Scott K; Yanow, Jessica

    2007-01-01

    This study examined the risk for alcoholism, diabetes, and depression (triADD) in American Indian/Alaska Native (AI/AN) populations in the U.S. Using the Behavioral Risk Factor Surveillance System, a series of descriptive statistics and regression models were used to examine the interrelationships among these disorders in AI/AN populations. Despite a small sample size, results indicate that AI/ANs are at elevated risk for the individual and combined presence of triADD (OR=12.5) when compared to the White population. These findings indicate the need for further investigation and prevention focused on effective, culturally appropriate interventions with these populations.

  8. Air surveillance

    Energy Technology Data Exchange (ETDEWEB)

    Patton, G.W.

    1995-06-01

    This section of the 1994 Hanford Site Environmental Report summarizes the air surveillance and monitoring programs currently in operation at that Hanford Site. Atmospheric releases of pollutants from Hanford to the surrounding region are a potential source of human exposure. For that reason, both radioactive and nonradioactive materials in air are monitored at a number of locations. The influence of Hanford emissions on local radionuclide concentrations was evaluated by comparing concentrations measured at distant locations within the region to concentrations measured at the Site perimeter. This section discusses sample collection, analytical methods, and the results of the Hanford air surveillance program. A complete listing of all analytical results summarized in this section is reported separately by Bisping (1995).

  9. Relationship of the area measurement of the large endolymphatic duct and sac syndrome as well as the clinical symptoms with CT and MR imaging results

    Energy Technology Data Exchange (ETDEWEB)

    Park, Ji Sang; Hong, Hyun Sook; Lee, Jong Sea; Kim, Dae Ho; Lee, Hae Kyung; Yi, Beom Ha; Cha, Jang Gyu; Park, Seong Jin; Kim, Shi Chan [Soonchunhyang University Bucheon Hospital, Bucheon (Korea, Republic of)

    2008-08-15

    To evaluate the CT and MRI findings of the large endolymphatic duct or sac syndrome (LEDS) and its associated anomalies, with clinical features. We retrospectively reviewed the MR and CT images of 52 ears obtained from 26 patients with LEDS. We reviewed the clinical findings, audiology testing, and treatment results. The degree of hearing loss was classified from normal to profound, based on pure tone audiometry. The largest areas were measured at each endolymphatic duct and analyzed to determine whether a correlation exists with the degree of hearing loss. We also analyzed the differences in measurements between CT and MRI findings. All 26 patients had some degree of sensorineural hearing loss, which resulted in 18 ears to undergo a cochlear implantation. One patient was diagnosed with Cornelia de Lange syndrome. Five patients had a sudden hearing loss onset. Ten ears had incomplete cochlear partitions, whereas 28 ears had enlarged vestibules. All patients had severe to profound hearing loss. We found no statistical correlation between the size of the largest area of the endolymphatic duct and the degree of hearing loss. The mean area of the endolymphatic ducts, as per an MRI examination, revealed slightly greater areas than the CT findings, although the differences were not significant. Enlarged vestibules and incomplete partitions of the cochlea were common anomalies associated with LEDS. We found no statistical correlation between the largest area of the endolymphatic duct or sac with the degree of hearing loss.

  10. The ultrastructure of the mature embryo sac in the natural tetraploid of red clover (Trifolium pratense L.: that has a very low rate of seed formation

    Directory of Open Access Journals (Sweden)

    Gönül Algan

    2014-01-01

    Full Text Available In this study, ultrastructural organization of cells in the mature embryo sac of natural tetraploid Trifolium pratense L. was investigated. The mature embryo sac of this plant contains an egg cell with two synergids at the micropylar end, and a central cell with two polar nuclei. The ultrastructure of these cells agrees with what is known for most angiosperms studied with the electron microscope. The egg cell is a large and highly vacuolate cell, partially surrounded by a wall. Much of the cytoplasm is located around the nucleus at the chalazal end and there are few numbers of channel-shaped endoplasmic reticulum, mitochondria, plastids and numerous ribosomes distributed throughout the cytoplasm. Unlike the egg cell, much of the cytoplasm in synergid cells is located at micropylar part of the cell and the synergid cytoplasm contains especially, large numbers of rough endoplasmic reticulum, free ribosomes, mitochondria and plastids. The central cell of T. pratense L. contains two large polar nuclei which lie close to the egg apparatus. Each polar nucleus has a single, large, dense nucleolus that contains several nucleolar vacuoles. Much of the central cell cytoplasm consisting of granular and agranular endoplasmic reticulum, mitochondria, plastids, ribosomes, dictyosomes and lipid bodies are placed around polar nuclei.

  11. An elective detection of an Amyand′s hernia with an adhesive caecum to the sac: Report of a rare case

    Directory of Open Access Journals (Sweden)

    Ilker Sengul

    2011-01-01

    Full Text Available Context: Existence of non-inflamed or inflamed vermiform appendix in an inguinal hernia is named Amyand′s hernia in honor to the surgeon Claudius Amyand who successfully performed first perforated appendicitis. Case Report: A 69-year-old Turkish male patient with a slight right groin pain and swelling was presented to our clinic, and found to have a slightly tender and reducible right inguinal hernia. He underwent surgery under general anesthesia, and a adhesive caecum and an inflamed appendix were explored within the hernia sac. Adhesions were divided by sharp dissection and appendectomy was performed. After carrying out a Lichtenstein hernioplasty, a broad-spectrum antibiotic was postoperatively admitted for 3 days. He recovered uneventfully, and neither complication nor recurrence was detected during 52 months of follow-up. Conclusions: Although occurrence of an appendicitis in an inguinal hernia is rare, a surgeon should be vigilant for facing with it even in elective cases. Treatment can be provided only surgically, but surgical treatment is not standard except from appendectomy. In our opinion, application of mesh hernia repair should depend on the degree of inflammation of appendix and the presence of incarceration of hernia sac with a suitable antibiotic admission for 3-5 days postoperatively.

  12. Optimisation of add-on NPN Transistor for a CMOS Process

    Science.gov (United States)

    Aurola, Artto; Ronkainen, Hannu; Mellin, Joni

    2004-01-01

    The objective of this research was to add an npn-bipolar transistor for a CMOS process. This was to be done with minimal additional process steps and without changing any existing CMOS parameters. The minimum line width of the process was 1.2µm, the wafers were p-type and 100mm in diameter and no epitaxial or polysilicon layers were used. To minimise the additional process steps a triple diffused transistor was selected as the basis of the research. The emitter was formed from a diffusion contacting NMOSFET source and drain to aluminium. As collector diffusion two approaches were investigated the pnpbipolar transistors isolation nwell and the PMOSFET n-well. The only additional step to the CMOS process due to the npn-transistor fabrication resulted from the formation of base diffusion. The specifications for the npn-transistor were 80 for the current gain, 100V for the early voltage and 60MHz for the transition frequency at 1µA collector current. Four different transistor structures were investigated two octagonal transistors having either emitter or base in the centre and two minimum area rectangular transistors having either base or emitter in the middle. The octagonal transistor having the emitter in the centre was chosen as the basis of simulations. It was first simulated with a device simulator. Next combined process and device simulations were done. Based on simulation results different processes were tested on wafers. Only the octagonal transistor having the emitter in the middle satisfied the specifications when a pnp isolation n-well was used as a collector.

  13. Inflammation in Patients with Schizophrenia: the Therapeutic Benefits of Risperidone Plus Add-On Dextromethorphan

    Science.gov (United States)

    Chen, Shiou-Lan; Lee, Sheng-Yu; Chang, Yun-Hsuan; Chen, Shih-Heng; Chu, Chun-Hsieh; Tzeng, Nian-Sheng; Lee, I-Hui; Chen, Po-See; Yeh, Tzung Lieh; Huang, San-Yuan; Yang, Yen-Kuang; Lu, Ru-Band; Hong, Jau-Shyong

    2013-01-01

    Objectives Increasing evidence suggests that inflammation contributes to the etiology and progression of schizophrenia. Molecules that initiate inflammation, such as virus- and toxin-induced cytokines, are implicated in neuronal degeneration and schizophrenia-like behavior. Using therapeutic agents with anti-inflammatory or neurotrophic effects may be beneficial for treating schizophrenia. Methods One hundred healthy controls and 95 Han Chinese patients with schizophrenia were tested in this double-blind study. Their PANSS scores, plasma interleukin (IL)-1β, TNF-α and brain-derived neurotrophic factor (BDNF) levels were measured before and after pharmacological treatment. Results Pretreatment, plasma levels of IL-1β and TNF-α were significantly higher in patients with schizophrenia than in controls, but plasma BDNF levels were significantly lower. Patients were treated with the atypical antipsychotic risperidone (Risp) only or with Risp+add-on dextromethorphan (DM). PANSS scores and plasma IL-1β levels significantly decreased, but plasma TNF-α and BDNF levels significantly increased after 11 weeks of Risp treatment. Patients in the Risp+DM group showed a greater and earlier reduction of symptoms than did those in the Risp-only group. Moreover, Risp+DM treatment attenuated Risp-induced plasma increases in TNF-α. Conclusion Patients with schizophrenia had a high level of peripheral inflammation and a low level of peripheral BDNF. Long-term Risp treatment attenuated inflammation and potentiated the neurotrophic function but also produced a certain degree of toxicity. Risp+DM was more beneficial and less toxic than Risp-only treatment. PMID:22730040

  14. What can neuromorphic event-driven precise timing add to spike-based pattern recognition?

    Science.gov (United States)

    Akolkar, Himanshu; Meyer, Cedric; Clady, Zavier; Marre, Olivier; Bartolozzi, Chiara; Panzeri, Stefano; Benosman, Ryad

    2015-03-01

    This letter introduces a study to precisely measure what an increase in spike timing precision can add to spike-driven pattern recognition algorithms. The concept of generating spikes from images by converting gray levels into spike timings is currently at the basis of almost every spike-based modeling of biological visual systems. The use of images naturally leads to generating incorrect artificial and redundant spike timings and, more important, also contradicts biological findings indicating that visual processing is massively parallel, asynchronous with high temporal resolution. A new concept for acquiring visual information through pixel-individual asynchronous level-crossing sampling has been proposed in a recent generation of asynchronous neuromorphic visual sensors. Unlike conventional cameras, these sensors acquire data not at fixed points in time for the entire array but at fixed amplitude changes of their input, resulting optimally sparse in space and time-pixel individually and precisely timed only if new, (previously unknown) information is available (event based). This letter uses the high temporal resolution spiking output of neuromorphic event-based visual sensors to show that lowering time precision degrades performance on several recognition tasks specifically when reaching the conventional range of machine vision acquisition frequencies (30-60 Hz). The use of information theory to characterize separability between classes for each temporal resolution shows that high temporal acquisition provides up to 70% more information that conventional spikes generated from frame-based acquisition as used in standard artificial vision, thus drastically increasing the separability between classes of objects. Experiments on real data show that the amount of information loss is correlated with temporal precision. Our information-theoretic study highlights the potentials of neuromorphic asynchronous visual sensors for both practical applications and theoretical

  15. Project DyAdd: classical eyeblink conditioning in adults with dyslexia and ADHD.

    Science.gov (United States)

    Laasonen, Marja; Kauppinen, Jenni; Leppämäki, Sami; Tani, Pekka; Harno, Hanna; Hokkanen, Laura; Wikgren, Jan

    2012-11-01

    In this study of the project DyAdd (Adult Dyslexia and Attention Deficit Disorder in Finland), classical eyeblink conditioning (EBC) was investigated in both delay and trace paradigms in adults (18-55 years) with dyslexia (n = 37), attention deficit-hyperactivity disorder (ADHD; n = 21), their comorbid combination (n = 8), and healthy controls (n = 35). In addition, the profiles of three participants with a rare autosomal dominant cerebellar disease were assessed (episodic ataxia type 2, EA-2). We found that participants with dyslexia were overall slower learners than controls in eyeblink conditioning. Further, they were the only group that had a reduced number of CRs in mediotemporal-dependent trace paradigm compared to the more cerebellum-dependent delay paradigm. Second, ADHD was found to be related to larger CR amplitude. Third, those with a comorbid condition learned faster and manifested CRs that were not well timed. Fourth, the cerebellar patients showed nearly no conditioning at all. Correlations between EBC and various neuropsychological domains (phonological processing, reading, spelling, arithmetic, executive functions, attention, and fine motor control) over all participants resulted in significant relations only for the delay paradigm: Increased amount of reading errors related with later peak latency and increased amount of self-corrections in fine motor control related with larger response magnitude. Within those who conditioned, relations emerged only for the trace paradigm: better spelling was related to larger response magnitude. These results do not lend support to the cerebellar hypothesis of dyslexia. On the contrary, dyslexia in its pure form seems to be related to a relative dysfunction of a larger hippocampal-cerebellar network. Further, larger responses in the ADHD group are suggested to result from their lowered responding threshold.

  16. Effect of clobazam as add-on antiepileptic drug in patients with epilepsy

    Directory of Open Access Journals (Sweden)

    Rupa Joshi

    2014-01-01

    Full Text Available Background & objectives: The use of clobazam in epilepsy has increased since its introduction in 1975. However, it has not been audited for its overall usefulness in Indian set up. The present study was aimed to evaluate usage pattern, retention rate, effectiveness and tolerability of clobazam during routine practice in an outpatient epilepsy clinic of a tertiary care hospital in New Delhi, India. Methods: This study was performed on the patients prescribed antiepileptic medication who had clobazam as last added drug in their treatment regimen during October 2010 - March 2012. These patients were followed up for two OPD visits. The primary points evaluated were retention rate, percentage of seizure-free patients and reasons for discontinuing clobazam. Results: o0 f the 417 consecutive patients, 132 (31.7% were on clobazam treatment for more than four years (median 6 yr, range 4-15 yr. No seizure for previous 12 months was considered as seizure free and was observed in 151 (36.2% patients. There was no improvement in seizure control in 32 (7.7% patients. A decrease in seizure severity without any change in seizure frequency was observed in 76 (18.2% patients. Clobazam was discontinued by 15 (3.6% patients due to complaints like drowsiness (13, fatigue/tiredness (8, headache (6, poor memory (6, irritable behaviour (5, abdominal pain (3 and dizziness (3. Interpretation & conclusions: Our results provide valuable information about the clinical use of clobazam as add-on antiepileptic drug therapy in the management of patients with epilepsy.

  17. Adult Dyslexia and Attention Deficit Disorder in Finland--Project DyAdd: WAIS-III Cognitive Profiles

    Science.gov (United States)

    Laasonen, Marja; Leppamaki, Sami; Tani, Pekka; Hokkanen, Laura

    2009-01-01

    The project Adult Dyslexia and Attention Deficit Disorder in Finland (Project DyAdd) compares adults (n = 119, 18-55 years) with dyslexia, attention-deficit/hyperactivity disorder (ADHD), dyslexia together with ADHD (comorbid), and healthy controls with neuropsychological, psychophysical, and biological methods. The focus of this article is on the…

  18. Marriage and Health in the Transition to Adulthood: Evidence for African Americans in the Add Health Study

    Science.gov (United States)

    Harris, Kathleen Mullan; Lee, Hedwig; DeLeone, Felicia Yang

    2010-01-01

    This article explores the relationships among early marriage (before age 26 years), cohabitation, and health for African Americans and Whites during the transition to adulthood using the National Longitudinal Study of Adolescent Health (Add Health). The study examines three categories of health outcomes relevant to young adulthood: physical…

  19. triADD: The Risk for Alcohol Abuse, Depression, and Diabetes Multimorbidity in the American Indian and Alaska Native Population

    Science.gov (United States)

    Tann, Sheila S.; Yabiku, Scott T.; Okamoto, Scott K.; Yanow, Jessica

    2007-01-01

    This study examined the risk for alcoholism, diabetes, and depression (triADD) in American Indian/Alaska Native (AI/AN) populations in the U.S. Using the Behavioral Risk Factor Surveillance System, a series of descriptive statistics and regression models were used to examine the interrelationships among these disorders in AI/AN populations.…

  20. 76 FR 65763 - Self-Regulatory Organizations; ICE Clear Credit LLC; Order Approving Proposed Rule Change To Add...

    Science.gov (United States)

    2011-10-24

    ..., other than with respect to certain conforming changes. \\4\\ Similar to the index credit default swap... COMMISSION Self-Regulatory Organizations; ICE Clear Credit LLC; Order Approving Proposed Rule Change To Add Rules Related to the Clearing of Emerging Markets Sovereigns October 18, 2011. I. Introduction On...

  1. 15 CFR 19.5 - How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce...

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce debt? 19.5 Section 19.5 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect...

  2. Auditory Discrimination in Depth (ADD)[R]/Lindamood Phonemic Sequencing (LiPS)[R]. What Works Clearinghouse Intervention Report

    Science.gov (United States)

    What Works Clearinghouse, 2007

    2007-01-01

    The "Auditory Discrimination in Depth (ADD) Program[R]" (currently called the "Lindamood Phonemic Sequencing (LiPS) Program[R]") is designed to teach students skills to successfully decode words and to identify individual sounds and blends in words. Initial activities engage students in discovering the lip, tongue, and mouth actions needed to…

  3. Does the Presence of a Hiatal Hernia Affect the Efficacy of the Reflux Inhibitor Baclofen During Add-On Therapy?

    NARCIS (Netherlands)

    H. Beaumont; G.E.E. Boeckxstaens

    2009-01-01

    OBJECTIVES: Reflux inhibitors, like the gamma-aminobutyric acid type B (GABA(B)) receptor agonist, baclofen, block transient lower esophageal sphincter relaxations (TLESRs) and are proposed as an add-on therapy in patients with proton pump inhibitor (PPI)-resistant gastroesophageal reflux. However,

  4. 31 CFR 5.5 - How will Treasury entities add interest, penalty charges, and administrative costs to a Treasury...

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false How will Treasury entities add interest, penalty charges, and administrative costs to a Treasury debt? 5.5 Section 5.5 Money and Finance: Treasury Office of the Secretary of the Treasury TREASURY DEBT COLLECTION Procedures To Collect...

  5. Measurement of the Economic Growth and Add-on of the R.M. Solow Adjusted Model

    Directory of Open Access Journals (Sweden)

    Ion Gh. Rosca

    2007-08-01

    Full Text Available Besides the models of M. Keynes, R.F. Harrod, E. Domar, D. Romer, Ramsey-Cass-Koopmans model etc., the R.M. Solow model is part of the category which characterizes the economic growth.The paper aim is the economic growth measurement and add-on of the R.M. Solow adjusted model.

  6. Cortical atrophy rates in Alzheimer's patients and subjects with mild cognitive impairment from the AddNeuroMed data collection

    DEFF Research Database (Denmark)

    Eskildsen, Simon Fristed; Westman, Eric; Gwadry-Sridhar, Femida;

    Background: The AddNeuroMed project is a multi-centre European project which aims to identify biomarkers in Alzheimer's disease (AD). In this study we measured the rate of cortical atrophy in AD patients, subjects with mild cognitive impairment (MCI), and healthy controls (HC) using MRI. Methods:...

  7. 40 CFR Table 1 to Subpart IIIi of... - Operating Limits for Capture Systems and Add-On Control Devices

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Operating Limits for Capture Systems... 63—Operating Limits for Capture Systems and Add-On Control Devices If you are required to comply with operating limits by § 63.3093, you must comply with the applicable operating limits in the following...

  8. Effect of “add-on” interventions on exercise training in individuals with COPD: a systematic review

    Directory of Open Access Journals (Sweden)

    Carlos A. Camillo

    2016-03-01

    Full Text Available The aim of this review was to identify the effectiveness of therapies added on to conventional exercise training to maximise exercise capacity in patients with chronic obstructive pulmonary disease (COPD. Electronic databases were searched, identifying trials comparing exercise training with exercise training plus “add-on” therapy. Outcomes included peak oxygen uptake (V′O2peak, work rate and incremental/endurance cycle and field walking tests. Individual trial effects on exercise capacity were extracted and collated into eight subgroups and pooled for meta-analysis. Sensitivity analyses were conducted to explore the stability of effect estimates across studies employing patient-centred designs and those deemed to be of “high” quality (PEDro score >5 out of 10. 74 studies (2506 subjects met review inclusion criteria. Interventions spanned a broad scope of clinical practice and were most commonly evaluated via the 6-min walking distance and V′O2peak. Meta-analysis revealed few clinically relevant and statistically significant benefits of “add-on” therapies on exercise performance compared with exercise training. Benefits favouring “add-on” therapies were observed across six different interventions (additional exercise training, noninvasive ventilation, bronchodilator therapy, growth hormone, vitamin D and nutritional supplementation. The sensitivity analyses included considerably fewer studies, but revealed minimal differences to the primary analysis. The lack of systematic benefits of “add-on” interventions is a probable reflection of methodological limitations, such as “one size fits all” eligibility criteria, that are inherent in many of the included studies of “add-on” therapies. Future clarification regarding the exact value of such therapies may only arise from adequately powered, multicentre clinical trials of tailored interventions for carefully selected COPD patient subgroups defined according to distinct

  9. Royal Danish Air Force. Air Operations Doctrine

    DEFF Research Database (Denmark)

    Nørby, Søren

    This brief examines the development of the first Danish Air Force Air Operations Doctrine, which was officially commissioned in October 1997 and remained in effect until 2010. The development of a Danish air power doctrine was heavily influenced by the work of Colonel John Warden (USAF), both...... through his book ”The Air Campaign” and his subsequent planning of the air campaign against Iraq in 1990-1991. Warden’s ideas came to Denmark and the Danish Air Force by way of Danish Air Force students attending the United States Air Force Air University in Alabama, USA. Back in Denmark, graduates from...... the Air University inspired a small number of passionate airmen, who then wrote the Danish Air Operations Doctrine. The process was supported by the Air Force Tactical Command, which found that the work dovetailed perfectly with the transformation process that the Danish Air Force was in the midst...

  10. Insights from a national survey into why substance abuse treatment units add prevention and outreach services

    Directory of Open Access Journals (Sweden)

    Lemak Christy

    2006-08-01

    Full Text Available Abstract Background Previous studies have found that even limited prevention-related interventions can affect health behaviors such as substance use and risky sex. Substance abuse treatment providers are ideal candidates to provide these services, but typically have little or no financial incentive to do so. The purpose of this study was therefore to explore why some substance abuse treatment units have added new prevention and outreach services. Based on an ecological framework of organizational strategy, three categories of predictors were tested: (1 environmental, (2 unit-level, and (3 unit leadership. Results A lagged cross-sectional logistic model of 450 outpatient substance abuse treatment units revealed that local per capita income, mental health center affiliation, and clinical supervisors' graduate degrees were positively associated with likelihood of adding prevention-related education and outreach services. Managed care contracts and methadone treatment were negatively associated with addition of these services. No hospital-affiliated agencies added prevention and outreach services during the study period. Conclusion Findings supported the study's ecological perspective on organizational strategy, with factors at environmental, unit, and unit leadership levels associated with additions of prevention and outreach services. Among the significant predictors, ties to managed care payers and unit leadership graduate education emerge as potential leverage points for public policy. In the current sample, units with managed care contracts were less likely to add prevention and outreach services. This is not surprising, given managed care's emphasis on cost control. However, the association with this payment source suggests that public managed care programs might affects prevention and outreach differently through revised incentives. Specifically, government payers could explicitly compensate substance abuse treatment units in managed care

  11. Increased inspiratory esophagogastric junction pressure in systemic sclerosis: An add-on to antireflux barrier

    Science.gov (United States)

    Nobre e Souza, Miguel Ângelo; Bezerra, Patrícia Carvalho; Nobre, Rivianny Arrais; Holanda, Esther Studart da Fonseca; dos Santos, Armênio Aguiar

    2015-01-01

    AIM: To investigate crural diaphragm (CD) function in systemic sclerosis (SSc) using high-resolution manometry and standardized inspiratory maneuvers. METHODS: Eight SSc volunteers (average age, 40.1 years; one male) and 13 controls (average age, 32.2 years; six males) participated in the study. A high-resolution manometry/impedance system measured the esophagus and esophagogastric junction (EGJ) pressure profile during swallows and two respiratory maneuvers: sinus arrhythmia maneuver (SAM; the average of six EGJ peak pressures during 5-s deep inhalations) and threshold maneuver (TM; the EGJ peak pressures during forced inhalation under 12 and 24 cmH2O loads). Inspiratory diaphragm lowering (IDL) was taken as the displacement of the EGJ high-pressure zone during the SAM. RESULTS: SSc patients had lower mean lower esophageal sphincter pressure than controls during normal breathing (19.7 ± 2.8 mmHg vs 32.2 ± 2.7 mmHg, P = 0.007). Sinus arrhythmia maneuver pressure was higher in SSc patients than in controls (142.6 ± 9.4 mmHg vs 104.6 ± 13.8 mmHg, P = 0.019). Sinus arrhythmia maneuver pressure normalized to IDL was also higher in SSc patients than in controls (83.8 ± 13.4 mmHg vs 37.5 ± 6.9 mmHg, P = 0.005). Threshold maneuver pressures normalized to IDL were also greater in SSc patients than in controls (TM 12 cmH2O: 85.1 ± 16.4 mmHg vs 43.9 ± 6.3 mmHg, P = 0.039; TM 24 cmH2O: 85.2 ± 16.4 mmHg vs 46.2 ± 6.6 mmHg, P = 0.065). Inspiratory diaphragm lowering in SSc patients was less than in controls (2.1 ± 0.3 cm vs 3 ± 0.2 cm, P = 0.011). CONCLUSION: SSc patients had increased inspiratory EGJ pressure. This is an add-on to EGJ pressure and indicates that the antireflux barrier can be trained. PMID:25717239

  12. Yolk sac nutrient composition and fat uptake in late-term embryos in eggs from young and old broiler breeder hens.

    Science.gov (United States)

    Yadgary, L; Cahaner, A; Kedar, O; Uni, Z

    2010-11-01

    In the present study, we examined the composition, amount, and uptake of yolk nutrients [fat, protein, water, and carbohydrates (COH)] during incubation of eggs from 30- and 50-wk-old broiler breeder hens. Eggs were sampled at embryonic d 0 (fresh eggs), 13, 15, 17, 19, and 21 (hatch). Egg, embryo, yolk content, and yolk sac membrane were weighed, and the yolk sac (YS; i.e., yolk content + yolk sac membrane) composition was analyzed. From 30 to 50 wk of age, the albumen weight increased by 13.3%, whereas the yolk increased by more than 40%. The proportion of fat in the fresh yolk of the 30-wk-old group was 23.8% compared with 27.4% in the 50-wk-old group, whereas the proportion of protein was 17.9% compared with 15.6%, respectively. During incubation, results indicated that water and protein infiltrated from other egg compartments to the YS. Accordingly, the calculated change in the content of water and protein between fresh yolk and sampled YS does not represent the true uptake of these components from the YS to the embryo, and only fat uptake from the YS can be accurately estimated. By embryonic d 15, fat uptake relative to embryo weight was lower in the 30-wk-old group than in the 50-wk-old group. However, by embryonic d 21, embryos of both groups reached similar relative fat uptake, suggesting that to hatch, embryos must attain a certain amount of fat as a source of energy for the hatching process. The amount of COH in the YS increased similarly during incubation in eggs from hens of both ages, reaching a peak at embryonic d 19, suggesting COH synthesis in the YS. At hatch, the amount of protein, water, and COH in the residual YS, relative to the weight of the yolk-free chick, was similar in eggs from young and old hens. However, chicks from the younger hens had less fat in the YS for their immediate posthatch nutrition compared with those from the older hens.

  13. In vitro potential modulation of baicalin and baicalein on P-glycoprotein activity and expression in Caco-2 cells and rat gut sacs.

    Science.gov (United States)

    Miao, Qing; Wang, Zhiyong; Zhang, Yuanyuan; Miao, Peipei; Zhao, Yuanyuan; Zhang, Yujie; Ma, Shuangcheng

    2016-09-01

    Context Previous studies have shown that Scutellariae Radix, the dried root of Scutellaria baicalensis Georgi (Labiatae), has a certain inhibitory effect on P-glycoprotein (P-gp), but the effects of its main active constituents on P-gp are still ambiguous. Objectives In vitro studies were performed to investigate the effects of its main active constituents (baicalin and its aglycone, baicalein) on the activity and expression of P-gp in intestine using Caco-2 cells and rat gut sacs. Materials and methods In Caco-2 cell experiments, the effects of baicalin and baicalein on P-gp activity were investigated using a P-gp substrate, rhodamine 123 and non-substrate fluorescein Na, by determining their intracellular fluorescence accumulation, and their effects on P-gp expression were determined using flow cytometry. In addition, rat gut sac model was selected to investigate the effects of baicalin and baicalein on the transport of verapamil, a classical P-gp substrate. The gut sacs of male Sprague-Dawley rats were filled with 0.4 mL the test solution contained verapamil (0.2575 mg/mL) and the drugs [baicalin and baicalein, at concentrations of 1/8 IC50 (59.875, 41.5 μg/mL), 1/4 IC50 (119.75, 83 μg/mL) and 1/2 IC50 (239.5, 166 μg/mL)], and then incubated in Tyrode's solution for a period of time. After termination of the incubation, the incubated solution was processed for the subsequent detection. Results According to the results of MTT assay, the IC50 values of verapamil, baicalin and baicalein were 104, 479, 332 μg/mL, respectively. The obtained results from the two models were confirmed mutually. As a result, baicalin exhibited no obvious effect on intracellular accumulation of Rh-123, and almost had no effect on P-gp expression and verapamil transportation, while baicalein significantly increased intracellular accumulation of Rh-123 (p P-gp expression (p p P-gp inhibitor, which presented obvious inhibitory effects on P-gp activity and expression

  14. GSPEL - Air Filtration Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — Evaluation capabilities for air filtration devices The Air Filtration Lab provides testing of air filtration devices to demonstrate and validate new or legacy system...

  15. Air-to-Air Missile Vector Scoring

    Science.gov (United States)

    2012-03-22

    64 4.6. Unscented Kalman Filter Performance in Air-to-Air Missile Scor - ing Application with Continuous Velocity Dynamics Model (Tar- get...Filter Performance in Air-to-Air Missile Scor - ing Application with Continuous Velocity Dynamics Model (Tar- get Aircraft Executing a Vertical Climb...Kalman Filter Performance in Air-to-Air Missile Scor - ing Application with Continuous Velocity Dynamics Model (Tar- get Aircraft Non-maneuvering

  16. Solar air conditioning: introduction and basics; Solare Klimatisierung Einfuehrung und Grundlagen

    Energy Technology Data Exchange (ETDEWEB)

    Albers, J. [Inst. fuer Erhaltung und Modernisierung von Bauwerken e.V. an der Technische Univ. Berlin (Germany)

    2005-07-01

    A considerable increase of the cold energy demand is expected world-wide in the coming years. Electrically operated cold compression plants are currently used at the most in order to meet the cold energy demand resulting also in a rising electric current and primary energy demand. This can have an effect on the supply security as well as on the change of the world climate. Therefore more alternative methods of cold generation are supposed to be applied in the future. The following contribution describes that plant systems for solar air conditioning (SAC-systems) are an attractive and feasible technology that demands engineering but can also be further developed and can make an important contribution to the target mentioned above. First an overview is provided of conventional air conditioning technology and of the expected development tendencies with regard to cold demand. Afterwards the currently available solar air conditioning methods and their possible applications are explained. (orig.)

  17. HPLC-MS analysis of Schisandra lignans and their metabolites in Caco-2 cell monolayer and rat everted gut sac models and in rat plasma

    Directory of Open Access Journals (Sweden)

    Jia-ming Yang

    2011-06-01

    Full Text Available The absorption profiles of Schisandra chinensis were evaluated using the human Caco-2 cell monolayer and rat everted gut sac models, as well as in rat plasma. By analyzing the chromatographic and MSn characteristics of individual peak acquired by HPLC-DAD-APCI-MSn determination, thirteen lignans were identified as the major in vitro absorbable components of the Schisandra extract. Most of these compounds were also detected and identified in rat plasma after an oral administration of the Schisandra extract, except for angeloyl(tigloylgomisin H and angeloyl(tigloylgomisin Q, whose structures possess an ester group at the cyclooctadiene ring. In addition, four metabolites, corresponding to the hydroxylation and demethylation products of schisandrin and the hydrolysis derivative of angeloyl(tigloylgomisin Q, were tentatively identified. The results demonstrate that Schisandra lignans are the major absorbable components of this crude drug, and hydroxylation, demethylation and hydrolysis are important metabolic transformations of the absorbable lignans.

  18. An add-on cap for ATR-IR spectroscopy studies

    DEFF Research Database (Denmark)

    2014-01-01

    The invention relates to a cap (300B) for an attenuated total reflectance infrared (ATR-IR) spectrometer, the ATR-IR spectrometer comprising an ATR-IR plate (200). The cap (300B) comprises an ATR- IR plate facing cap surface. When the ATR-IR plate facing cap surface is placed on the sample surface...... side of the ATR-IR plate (200), a sample cavity enclosing the sample is formed between the sample surface side of the ATR-IR plate (200) and the ATR-IR plate facing cap surface of the cap (300B). This sample cavity can be an air tight cavity. The cap may further comprise a bridge (322), which functions...... as cap securing means (322), as the cap (300B) is secured onto the ATR-IR plate (200) by a pressure clamp (108) and an arm (110) holding the pressure clamp (108) pressing on the bridge (322)....

  19. Unenhanced Cone Beam Computed Tomography and Fusion Imaging in Direct Percutaneous Sac Injection for Treatment of Type II Endoleak: Technical Note

    Energy Technology Data Exchange (ETDEWEB)

    Carrafiello, Gianpaolo, E-mail: gcarraf@gmail.com; Ierardi, Anna Maria [Insubria University, Interventional Radiology, Department of Radiology (Italy); Radaelli, Alessandro [Philips Healthcare (Netherlands); Marchi, Giuseppe De; Floridi, Chiara [Insubria University, Interventional Radiology, Department of Radiology (Italy); Piffaretti, Gabriele [University of Insubria, Vascular Surgery Department (Italy); Federico, Fontana [Insubria University, Interventional Radiology, Department of Radiology (Italy)

    2016-03-15

    AimTo evaluate safety, feasibility, technical success, and clinical success of direct percutaneous sac injection (DPSI) for the treatment of type II endoleaks (T2EL) using anatomical landmarks on cone beam computed tomography (CBCT) and fusion imaging (FI).Materials and MethodsEight patients with T2EL were treated with DPSI using CBCT as imaging guidance. Anatomical landmarks on unenhanced CBCT were used for referencing T2EL location in the first five patients, while FI between unenhanced CBCT and pre-procedural computed tomography angiography (CTA) was used in the remaining three patients. Embolization was performed with thrombin, glue, and ethylene–vinyl alcohol copolymer. Technical and clinical success, iodinated contrast utilization, procedural time, fluoroscopy time, and mean radiation dose were registered.ResultsDPSI was technically successful in all patients: the needle was correctly positioned at the first attempt in six patients, while in two of the first five patients the needle was repositioned once. Neither minor nor major complications were registered. Average procedural time was 45 min and the average administered iodinated contrast was 13 ml. Mean radiation dose of the procedure was 60.43 Gy cm{sup 2} and mean fluoroscopy time was 18 min. Clinical success was achieved in all patients (mean follow-up of 36 months): no sign of T2EL was reported in seven patients until last CT follow-up, while it persisted in one patient with stability of sac diameter.ConclusionsDPSI using unenhanced CBCT and FI is feasible and provides the interventional radiologist with an accurate and safe alternative to endovascular treatment with limited iodinated contrast utilization.

  20. R9 Air Districts

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Region 9 Air Districts layer is a compilation of polygons representing the California Air Pollution Control and Air Quality Management Districts, Arizona Air...

  1. AirData

    Data.gov (United States)

    U.S. Environmental Protection Agency — The AirData site provides access to yearly summaries of United States air pollution data, taken from EPA's air pollution databases. AirData has information about...

  2. California Air Basins

    Data.gov (United States)

    California Department of Resources — Air ResourcesCalifornia Air Resources BoardThe following datasets are from the California Air Resources Board: * arb_california_airbasins - California Air BasinsThe...

  3. A method to add richness to the National Landslide Database of Great Britain

    Science.gov (United States)

    Taylor, Faith; Freeborough, Katy; Malamud, Bruce; Demeritt, David

    2014-05-01

    2012, 72 of these resulted in additions to the BGS NLD and 4 in amendments to previously collected information. This raises the total number of landslides reported in 2012 from 186 to 258. Using the increased presence of landslides in the news and social media, 2012 had already resulted in the largest number of landslides for a given year being recorded by BGS in the NLD. With the additions from this current study to the NLD, we estimate that the annual total number of landslides was around six times higher in 2012 than the average annual total between 2006 and 2011. Years prior to 2012 plan to be revisited using this method, and more broadly, this method of searching newspaper archives could be applied to many other natural hazards to add richness to databases of historical events and improve our understanding of hazard occurrence and impact.

  4. BpuAmI: a novel SacI neoschizomer from Bacillus pumilus discovered in an isolate from Amazon Basin, recognizing 5'-GAG¯CTC-3' BpuAmI: um novo neoesquisomero de SacI de Bacillus pumilus descoberta em um isolado oriundo da Bacia Amazônica, reconhecendo 5'-GAG¯CTC-3'

    Directory of Open Access Journals (Sweden)

    Jocelei M. Chies

    2006-03-01

    Full Text Available A strain of Bacillus pumilus was isolated and identified from water samples collected from a small affluent of the Amazon River. Type II restriction endonuclease activity was detected in these bacteria. The enzyme was purified and the molecular weight of the native protein estimated by gel filtration and SDS-PAGE. The optimum pH, temperature and salt requirements were determined. Quality control assays showed the complete absence of "nonspecific nucleases." Restriction cleavage analysis and DNA sequencing of restriction fragments allowed the unequivocal demonstration of 5´GAG¯CTC3´ as the recognition sequence. This enzyme was named BpuAmI and is apparently a neoschizomer of the prototype restriction endonuclease SacI. This is the first report of an isoschizomer and/or neoschizomer of the prototype SacI identified in the genus Bacillus.Uma linhagem de Bacillus pumilus foi isolada e identificada de amostras de águas coletadas em um pequeno Igarapé do Rio Amazonas. Foi detectada atividade de restrição do tipo II nesta bactéria. A enzima foi purificada e o peso molecular da proteína nativa foi estimado por gel filtração e por eletroforese em gel de poliacrilamida. Foram determinados, o pH e temperatura ótimos e as necessidades de sais. Os ensaios do controle de qualidade mostraram uma ausência completa de "nucleases não específicas". As analises das clivagens e o seqüenciamento do DNA dos fragmentos de restrição permitiram uma demonstração inequívoca de que 5´GAG¯CTC 3´ é a seqüência de reconhecimento da enzima. Esta enzima foi denominada de BpuAmI e aparentemente é um neoesquisômero da enzima protótipo SacI. Este é o primeiro relato de um isoesquisômero e/ou neoesquisômero da enzima protótipo SacI identificada no gênero Bacillus.

  5. Drell-Yan, ZZ, W+W- production in SM & ADD model to NLO+PS accuracy at the LHC

    CERN Document Server

    Frederix, R; Mathews, P; Ravindran, V; Seth, S

    2014-01-01

    In this paper, we present the next-to-leading order QCD corrections for di-lepton, di-electroweak boson (ZZ, W+W-) production in both the SM and the ADD model, matched to the HERWIG parton-shower using the aMC@NLO framework. A selection of results at the 8 TeV LHC, which exhibits deviation from the SM as a result of the large extra-dimension scenario are presented.

  6. The reliability of in-home measures of height and weight in large cohort studies: Evidence from Add Health

    Directory of Open Access Journals (Sweden)

    Jon Hussey

    2015-05-01

    Full Text Available Background: With the emergence of obesity as a global health issue, an increasing number of major demographic surveys are collecting measured anthropometric data. Yet little is known about the characteristics and reliability of these data. Objective: We evaluate the accuracy and reliability of anthropometric data collected in the home during Wave IV of the National Longitudinal Study of Adolescent to Adult Health (Add Health, compare our estimates to national standard, clinic-based estimates from the National Health and Nutrition Examination Survey (NHANES and, using both sources, provide a detailed anthropometric description of young adults in the United States. Methods: The reliability of Add Health in-home anthropometric measures was estimated from repeat examinations of a random subsample of study participants. A digit preference analysis evaluated the quality of anthropometric data recorded by field interviewers. The adjusted odds of obesity and central obesity in Add Health vs. NHANES were estimated with logistic regression. Results: Short-term reliabilities of in-home measures of height, weight, waist and arm circumference - as well as derived body mass index (BMI, kg/m2 - were excellent. Prevalence of obesity (37Š vs. 29Š and central obesity (47Š vs. 38Š was higher in Add Health than in NHANES, while socio-demographic patterns of obesity and central obesity were comparable in the two studies. Conclusions: Properly trained non-medical field interviewers can collect reliable anthropometric data in a nationwide, home visit study. This national cohort of young adults in the United States faces a high risk of early-onset chronic disease and premature mortality.

  7. High Speed, Low Power, Area Efficient Mux-Add and Bec Based Implementation of Carry Select Adder.

    OpenAIRE

    Assistant Professor New Horizon College of Engineering

    2013-01-01

    Adder being the basic hardware block of any arithmetic operation, the major constraint in the field of signal processors, data processors to perform any operations are highly dependent on the adder performance of the circuit. The gate level implementation of the carry select adder (CSLA) and modified carry select adder has significantly reduced the area and power consumption which replaced the ripple carry adder (RCA) used in modified CSLA with MUX-ADD block has further reduced the power ...

  8. Characterization of the Distal Polyadenylation Site of the ß-Adducin (Add2) Pre-mRNA

    Science.gov (United States)

    Costessi, Luisa; Porro, Fabiola; Iaconcig, Alessandra; Nedeljkovic, Mirjana; Muro, Andrés Fernando

    2013-01-01

    Most genes have multiple polyadenylation sites (PAS), which are often selected in a tissue-specific manner, altering protein products and affecting mRNA stability, subcellular localization and/or translability. Here we studied the polyadenylation mechanisms associated to the beta-adducin gene (Add2). We have previously shown that the Add2 gene has a very tight regulation of alternative polyadenylation, using proximal PAS in erythroid tissues, and a distal one in brain. Using chimeric minigenes and cell transfections we identified the core elements responsible for polyadenylation at the distal PAS. Deletion of either the hexanucleotide motif (Hm) or the downstream element (DSE) resulted in reduction of mature mRNA levels and activation of cryptic PAS, suggesting an important role for the DSE in polyadenylation of the distal Add2 PAS. Point mutation of the UG repeats present in the DSE, located immediately after the cleavage site, resulted in a reduction of processed mRNA and in the activation of the same cryptic site. RNA-EMSA showed that this region is active in forming RNA-protein complexes. Competition experiments showed that RNA lacking the DSE was not able to compete the RNA-protein complexes, supporting the hypothesis of an essential important role for the DSE. Next, using a RNA-pull down approach we identified some of the proteins bound to the DSE. Among these proteins we found PTB, TDP-43, FBP1 and FBP2, nucleolin, RNA helicase A and vigilin. All these proteins have a role in RNA metabolism, but only PTB has a reported function in polyadenylation. Additional experiments are needed to determine the precise functional role of these proteins in Add2 polyadenylation. PMID:23554949

  9. Characterization of the distal polyadenylation site of the ß-adducin (Add2 pre-mRNA.

    Directory of Open Access Journals (Sweden)

    Luisa Costessi

    Full Text Available Most genes have multiple polyadenylation sites (PAS, which are often selected in a tissue-specific manner, altering protein products and affecting mRNA stability, subcellular localization and/or translability. Here we studied the polyadenylation mechanisms associated to the beta-adducin gene (Add2. We have previously shown that the Add2 gene has a very tight regulation of alternative polyadenylation, using proximal PAS in erythroid tissues, and a distal one in brain. Using chimeric minigenes and cell transfections we identified the core elements responsible for polyadenylation at the distal PAS. Deletion of either the hexanucleotide motif (Hm or the downstream element (DSE resulted in reduction of mature mRNA levels and activation of cryptic PAS, suggesting an important role for the DSE in polyadenylation of the distal Add2 PAS. Point mutation of the UG repeats present in the DSE, located immediately after the cleavage site, resulted in a reduction of processed mRNA and in the activation of the same cryptic site. RNA-EMSA showed that this region is active in forming RNA-protein complexes. Competition experiments showed that RNA lacking the DSE was not able to compete the RNA-protein complexes, supporting the hypothesis of an essential important role for the DSE. Next, using a RNA-pull down approach we identified some of the proteins bound to the DSE. Among these proteins we found PTB, TDP-43, FBP1 and FBP2, nucleolin, RNA helicase A and vigilin. All these proteins have a role in RNA metabolism, but only PTB has a reported function in polyadenylation. Additional experiments are needed to determine the precise functional role of these proteins in Add2 polyadenylation.

  10. Characteristics of an add-drop filter composed of a Mach-Zehnder interferometer and double ring resonators

    Institute of Scientific and Technical Information of China (English)

    Fufei Pang; Xiuyou Han; Haiwen Cai; Ronghui Qu; Zujie Fang

    2005-01-01

    @@ A planar lightwave circuit (PLC) add-drop filter is proposed and analyzed, which consists of a symmetric Mach-Zehnder interferometer (MZI) combined with double microring resonators. A critical coupling condition is derived for a better box-like drop spectrum. Comparisons of its characteristics with other schemes,such as a MZI with a single ring resonator, are presented, and some of the issues about device design and fabrication are also discussed.

  11. Air Warfare

    Science.gov (United States)

    2002-03-01

    undoubtedly begat the shield; poisonous gases were countered by the mask. Surely men on the surface of the earth will not have to submit to violent air attack...properties, production methods and cost of helium are given in “Balloon and Airship Gases ,” a volume of the Ronald Aeronautic Library. 5 More complete...becomes and more inse - cure. We shall see later that even some of the men who were advancing in the path prescribed by the principle of mass

  12. Evaluation of homoeopathic medicines as add-on to institutional management protocol in Acute Encephalitis Syndrome: An exploratory observational comparative study

    Directory of Open Access Journals (Sweden)

    Raj K Manchanda

    2015-01-01

    Conclusion: This exploratory observational study suggests reduction of mortality and morbidity with add-on homoeopathic medicine. Further randomized controlled trial study with comparable groups is desirable. If findings are confirmed by subsequent research, add-on Homoeopathy might have relevant implication for its management.

  13. 40 CFR 63.3967 - How do I establish the emission capture system and add-on control device operating limits during...

    Science.gov (United States)

    2010-07-01

    ... system and add-on control device operating limits during the performance test? 63.3967 Section 63.3967... capture system and add-on control device operating limits during the performance test? During the... the operating limits required by § 63.3892 according to this section, unless you have...

  14. 40 CFR 63.9324 - How do I establish the emission capture system and add-on control device operating limits during...

    Science.gov (United States)

    2010-07-01

    ... capture system and add-on control device operating limits during the performance test? 63.9324 Section 63... Requirements § 63.9324 How do I establish the emission capture system and add-on control device operating... the operating limits required by § 63.9302 according to this section, unless you have...

  15. 75 FR 48894 - Approval and Promulgation of Air Quality Implementation Plans; New Mexico; Revisions to Emissions...

    Science.gov (United States)

    2010-08-12

    ... AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; New Mexico... Mexico State Implementation Plan (SIP). These revisions concern two separate actions. First, we are... pollutants such as ozone, particulate matter, and carbon monoxide. The revisions add new definitions,...

  16. Birds of Santa Teresa, Espírito Santo, Brazil: do humans add or subtract species?

    Directory of Open Access Journals (Sweden)

    Edwin O. Willis

    2002-11-01

    Full Text Available In uplands and lowlands of Santa Teresa, central Espírito Santo State, Brazil, 405 bird species were confirmed by field, museum, and literature studies. Of these, 16 seem to have disappeared, while 67 other species seem to have been lost from the lowlands (where no large biological reserves exist. Due to a suggestion that human areas add species to beta-diversity, we verified that up to 79 species now present have perhaps "invaded" with human activity (and 10 others are likely to invade, a total similar to that for lost species. However, lost species are often rare and invading species often widespread, resulting in exchange of "Picassos for Coca-Cola bottles." Furthermore, gains exceed losses only when large biological reserves are present, as in the uplands (Nova Lombardia, Santa Lúcia Reserves, each with over 250 species. Small or irregular reserves usually lose well over half their species, and these are only partly replaced by the invaders, resulting in net losses of up to half the local avifaunas. If one lists only 31 probable invaders, rather than a possible 79, things are even worse; net losses occur even in the entire township and near reserves, reaching over 200 species around lowland private reserves. Future "productive" development of human areas can eliminate or maltreat many invading species, too. While approving taxes on improductive use of land, as it leaves other areas free, we suggest that many current local "uses," such as for coffee, are "luxury" production and could be taxed.Nas terras altas e baixas de Santa Teresa, região central do Estado de Espírito Santo, Brasil, 405 espécies de aves foram confirmadas por estudos de campo, museu e de literatura. Destas, 16 parecem ter desaparecido, enquanto outras 67 espécies parecem ter sido perdidas nas baixadas (onde não existem reservas biológicas de grande extensão. Baseado na sugestão de que as áreas humanas adicionam espécies à beta diversidade, nós verificamos que

  17. Maximizing the reactivity of phenolic and aminic radical-trapping antioxidants: just add nitrogen!

    Science.gov (United States)

    Valgimigli, Luca; Pratt, Derek A

    2015-04-21

    Hydrocarbon autoxidation, the archetype free radical chain reaction, challenges the longevity of both living organisms and petroleum-derived products. The most important strategy in slowing this process is via the intervention of radical-trapping antioxidants (RTAs), which are abundant in nature and included as additives to almost every petroleum-derived product as well as several other commercial products. Accordingly, a longstanding objective of many academic and industrial scientists has been the design and development of novel RTAs that can outperform natural and industrial standards, such as α-tocopherol, the most biologically active form of vitamin E, and dialkylated diphenylamines, respectively. Some time ago we recognized that attempts to maximize the reactivity of phenolic RTAs had largely failed because substitution of the phenolic ring with electron-donating groups to weaken the O-H bond and accelerate the rate of H atom transfer to radicals leads to compounds that are unstable in air. We surmised that incorporating nitrogen into the phenolic ring would render them more stable to one-electron oxidation, enabling their substitution with strong electron-donating groups. Guided by computational chemistry, we demonstrated that replacing the phenyl ring in very electron-rich phenols with either 3-pyridyl or 5-pyrimidyl rings leads to phenolic-like RTAs with good air stability and great reactivity. In fact, rate constants determined for the reactions of some compounds with peroxyl radicals were almost 2 orders of magnitude greater than those for α-tocopherol and implied that the reactions proceeded without an enthalpic barrier. Following extensive thermochemical and kinetic characterization, we took our studies of these compounds to more physiologically relevant media, such as lipid bilayers and human low density lipoproteins, where the heterocyclic analogues of vitamin E shone, displaying unparalleled abilities to inhibit lipid peroxidation and prompting

  18. Low-Flow Liquid Desiccant Air Conditioning: General Guidance and Site Considerations

    Energy Technology Data Exchange (ETDEWEB)

    Kozubal, E.; Herrmann, L.; Deru, M.; Clark, J.

    2014-09-01

    Dehumidification or latent cooling in buildings is an area of growing interest that has been identified as needing more research and improved technologies for higher performance. Heating, ventilating, and air-conditioning (HVAC) systems typically expend excessive energy by using overcool-and-reheat strategies to dehumidify buildings. These systems first overcool ventilation air to remove moisture and then reheat the air to meet comfort requirements. Another common strategy incorporates solid desiccant rotors that remove moisture from the air more efficiently; however, these systems increase fan energy consumption because of the high airside pressure drop of solid desiccant rotors and can add heat of absorption to the ventilation air. Alternatively, liquid desiccant air-conditioning (LDAC) technology provides an innovative dehumidification solution that: (1) eliminates the need for overcooling and reheating from traditional cooling systems; and (2) avoids the increased fan energy and air heating from solid desiccant rotor systems.

  19. 儿童卵黄囊瘤病理学特征及鉴别诊断%Pathological characteristics and differential diagnosis of yolk sac tumor in children

    Institute of Scientific and Technical Information of China (English)

    许恪淳; 管雯斌; 许艳春; 姚晓虹; 王立峰; 祝明洁

    2013-01-01

    Objective To investigate the pathological features of yolk sac tumor ( YST) in children, determine the immunohistochemical characteristics and their role in pathological diagnosis of YST, and discuss the differential diagnosis of YST. Methods The clinical data of 21 cases of YST were retrospectively summarized, among which 8 were concerned with gonad, and the other 13 non-gonad. The characteristics of histology and immunohistochemical staining were observed. Results There were various pathological organizations for YST. There was micro capsule and reticular structure in 17 cases, embryo sinus structure in 16 cases, gland tube-gland bubble structure in 10 cases, papillary structure in 8 cases, giant cystic structure in 3 cases, intestinal type structure in 3 cases, polycystic bubble yolk sac sample structure in 2 cases and mucus tumor sample structure in 1 case. Immunohistochemical staining revealed that the positive expression rate of alpha-fetoprotein (AFP) was 95. 24% (20/21), that of cytokeratin ( CK) was 100% (21/21), and that of vimentin ( Vim) was 76. 19% (16/21) . Conclusion Besides gonad (testis and ovary), YST in children can also involve non-gonad parts such as sacroiliac region, abdominopelvic cavity, cerebellum and soft tissues. The histological features of YST are diverse, which are characterized by the common structures such as micro capsule and reticular structure, inner embryo sinus structure, gland tube-gland bubble structure and papillary structure and rare structures such as giant cystic structure, intestinal type structure, mucus tumor sample structure and polycystic bubble yolk sac sample structure. Histomorphological characteristics and immunohistochemical findings may help to determine the pathological diagnosis and differential diagnosis of YST.%目的 了解儿童卵黄囊瘤(YST)的组织形态学特征,明确免疫组织化学特点及其在YST病理学诊断中的作用,探讨YST鉴别诊断要点.方法 回顾总结21例YST(性腺8

  20. A review of modafinil and armodafinil as add-on therapy in antipsychotic-treated patients with schizophrenia.

    Science.gov (United States)

    Wittkampf, Laura Christina; Arends, Johannes; Timmerman, Leo; Lancel, Marike

    2012-06-01

    Schizophrenia is characterized by reality distortion, psychomotor poverty and cognitive disturbances. These characteristics contribute to a lesser social functioning and lower quality of life in patients with schizophrenia. It has been suggested that modafinil and its isomer armodafinil as an add-on strategy to antipsychotic treatment in patients with schizophrenia may improve cognitive functioning, attenuate fatigue, inactiveness and other negative functions as well as weight gain. In this paper we review the literature relevant to the question of whether modafinil and armodafinil are beneficial as add-on therapy in antipsychotic-treated patients with schizophrenia. A total of 15 articles were included in this review; of the 15 articles, 10 were randomized controlled trials (RCTs). Evidence for the use of modafinil or armodafinil as add-on therapy to antipsychotic drugs to alleviate fatigue, sleepiness and inactivity is inconclusive. One cohort study and one out of two single-dose crossover RCTs in which modafinil addition was studied could demonstrate a positive effect. All five RCTs of modafinil (three RCTs) and armodafinil (two RCTs) addition with a longer study duration could not demonstrate a positive effect. With respect to cognitive disturbances, animal models of cognitive deficits show clear improvements with modafinil. In RCTs with a treatment duration of 4 weeks or more, however, no positive effect could be demonstrated on cognitive functioning with modafinil and armodafinil addition. Yet, four single-dose crossover RCTs of modafinil addition show significant positive effects on executive functioning, verbal memory span, visual memory, working memory, spatial planning, slowing in latency, impulse control and recognition of faces expressing sadness and sadness misattribution in the context of disgust recognition. The addition of modafinil or armodafinil to an antipsychotic regime, despite theoretical and preclinical considerations, has not been proved to

  1. Air filtration and indoor air quality

    DEFF Research Database (Denmark)

    Bekö, Gabriel

    2006-01-01

    decent ventilation and air cleaning/air filtration, high indoor air quality cannot be accomplished. The need for effective air filtration has increased with increasing evidence on the hazardous effects of fine particles. Moreover, the air contains gaseous pollutants, removal of which requires various air....... These contradictions should motivate manufacturers and researchers to develop new efficient filtration techniques and/or improve the existing ones. Development of low polluting filtration techniques, which are at the same time easy and inexpensive to maintain is the way forward in the future....

  2. Combined oculoplastic operation for contracted conjunctival sac and depressed eye socket of anophthalmos%Ⅱ期眼窝凹陷及结膜囊狭窄的联合整复手术

    Institute of Scientific and Technical Information of China (English)

    张向荣; 周琼; 裴重刚; 周荃; 高长华

    2011-01-01

    目的 探讨眼球摘除或眼内容物剜出术后眼窝内陷伴结膜囊狭窄的同期整复手术方法及临床疗效。方法 对2007年8月至2010年5月收治35例患者施行Ⅱ期义眼座植入联合结膜囊成形术,其中7例结膜囊轻度缺损采用下、上穹窿结膜划开;23例结膜囊中度缺损采用异体巩膜;5例结膜囊重度缺损采用自体唇粘膜移植。所有病例结膜囊内眼模支撑,轻、中度组行睑缘临时缝合,术后1月拆线,自体唇黏膜移植组行部分睑缘粘连术,术后3个月分开眼睑,试装义眼。观察术后眼窝内陷矫正、结膜囊成形情况。随访3~6月。结果 术后所有患者眼窝内陷明显改善,结膜囊成形良好,穹窿深浅可,均可配戴适合的义眼,活动度可。结论 Ⅱ期义眼座植入联合结膜囊成形术是治疗眼球摘除或眼内容物剜出术后眼窝内陷伴结膜囊狭窄的理想手术。%Objective To explore combined oculoplastic surgery methods for treating narrow conjunctival sac and sunk socket after enucleation or evisceration. Methods Thirty-five cases with narrow conjunctival sac and sunk socket were treated with secondary hydroxyapatite or Medpor orbital implantation combined with plasty of the cul - de - sac. Seven cases with mild impairment were cut open the bottom or top of the conjunctival fomix, 23 patients with moderate impairment were repaired by preserved sclera conjunctival sac, 5 eases of severe conjunctival defect were repaired by autologous oral mucosa transplants. An eye substitute was put in the conjunctival sac in every case. In mild and moderate impairment groups temporary palpebral suture were done, the eyelids were opened lmonth after surgery. The superior and lower eyelids were closed with partial blepharorrhaphy in oral mucosa transplant groups and the eyelids were opened 3 months after surgery and a suitable prosthesis was implanted. We observed the rectified sunk socket, the shaping

  3. PAOLO: a Polarimeter Add-On for the LRS Optics at a Nasmyth focus of the TNG

    CERN Document Server

    Covino, S; Bruno, P; Cecconi, M; Conconi, P; D'Avanzo, P; di Fabrizio, L; Fugazza, D; Giarrusso, M; Giro, E; Leone, F; Lorenzi, V; Scuderi, S

    2013-01-01

    We describe a new polarimetric facility available at the Istituto Nazionale di AstroFisica / Telescopio Nazionale Galileo at La Palma, Canary islands. This facility, PAOLO (Polarimetric Add-On for the LRS Optics), is located at a Nasmyth focus of an alt-az telescope and requires a specific modeling in order to remove the time- and pointing position-dependent instrumental polarization. We also describe the opto-mechanical structure of the instrument and its calibration and present early examples of applications.

  4. Tutorial sobre programa MultiEval: Cómo utilizar MultiEval y el ADD (material para alumnos)

    OpenAIRE

    Diaz-Foncea, Millan

    2011-01-01

    Este tutorial ha sido elaborado para que el alumnado tenga acceso al mismo ante posibles problemas al bajar, realizar y subir ejercicios con el programa MultiEval al Anillo Digital Docente (ADD) de la Universidad de Zaragoza. Está editado para ser utilizado en la Asignatura Fundamentos de Administración y Dirección de Empresas del Grado de Administración y Dirección de Empresas (GADE), Grado en Finanzas y Contabilidad (FICO), el Grado en Marketing e Investigación de mercado (MIM) y el Doble ...

  5. High Speed, Low Power, Area Efficient Mux-Add and Bec Based Implementation of Carry Select Adder.

    Directory of Open Access Journals (Sweden)

    Assistant Professor New Horizon College of Engineering

    2013-11-01

    Full Text Available Adder being the basic hardware block of any arithmetic operation, the major constraint in the field of signal processors, data processors to perform any operations are highly dependent on the adder performance of the circuit. The gate level implementation of the carry select adder (CSLA and modified carry select adder has significantly reduced the area and power consumption which replaced the ripple carry adder (RCA used in modified CSLA with MUX-ADD block has further reduced the power consumption by efficiently utilizing the area with faster performance.

  6. Usage of OpenStack Virtual Machine and MATLAB HPC Add-on leads to faster turnaround

    KAUST Repository

    Van Waveren, Matthijs

    2017-03-16

    We need to run hundreds of MATLAB® simulations while changing the parameters between each simulation. These simulations need to be run sequentially, and the parameters are defined manually from one simulation to the next. This makes this type of workload unsuitable for a shared cluster. For this reason we are using a cluster running in an OpenStack® Virtual Machine and are using the MATLAB HPC Add-on for submitting jobs to the cluster. As a result we are now able to have a turnaround time for the simulations of the order of a few hours, instead of the 24 hours needed on a local workstation.

  7. Air pollution

    Energy Technology Data Exchange (ETDEWEB)

    1974-12-01

    Air pollution conditions in Iwakuni city were monitored at 9 monitoring stations, and 21 locations where sulfur oxides were measured by the lead peroxide candle method, and 13 locations where particulates concentrations were determined by the deposit cage method. The average SO/sub x/ concentrations in 1973 measured by the lead peroxide candle method ranged from 0.17 mg sulfur trioxide/day/100 sq cm at the Miso Office to 0.58 mg SO/sub 3//day/100 sq cm at Mitsui Sekiyu Shataku. The average SO/sub x/ concentrations measured by the conductivity method ranged from 0.021 ppM at Kazuki Kominkan to 0.037 ppM at the Higashi Fire Department. Only 58% of a total of 264 measurement days gave hourly average concentrations below the environmental standard of 0.04 ppM at the Higashi Fire Deparment. The average airborne particulate concentrations ranged from 0.050 mg/cu m at Totsu Kominkan to 0.056 mg/cu at the Higashi Fire Department. The average nitrogen oxides concentrations measured by the Saltzman method ranged from 0.007 ppM to 0.061 ppM. The average oxidant concentrations at the Iwakuni Municipal Office and Kazuki Kominkan were 0.028 ppM and 0.037 ppM, respectively.

  8. A television in the bedroom is associated with higher weekday screen time among youth with attention deficit hyperactivity disorder (ADD/ADHD)

    OpenAIRE

    Charmaine B. Lo; Waring, Molly E.; Pagoto, Sherry L.; Lemon, Stephenie C.

    2014-01-01

    Objective: A TV in the bedroom has been associated with screen time in youth. Youth with attention deficit hyperactivity disorder (ADD/ADHD) have higher rates of screen time, but associations with bedroom TVs are unknown in this population. We examined the association of having a bedroom TV with screen time among youth with ADD/ADHD. Methods: Data were from the 2007 National Survey of Children's Health. Youth 6–17 years whose parent/guardian reported a physician's diagnosis of ADD/ADHD (n ...

  9. Air Sensor Toolbox

    Science.gov (United States)

    Air Sensor Toolbox provides information to citizen scientists, researchers and developers interested in learning more about new lower-cost compact air sensor technologies and tools for measuring air quality.

  10. HEPA air filter (image)

    Science.gov (United States)

    ... pet dander and other irritating allergens from the air. Along with other methods to reduce allergens, such ... controlling the amount of allergens circulating in the air. HEPA filters can be found in most air ...

  11. GSPEL - Air Filtration Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — Evaluation capabilities for air filtration devicesThe Air Filtration Lab provides testing of air filtration devices to demonstrate and validate new or legacy system...

  12. Lead (Pb) Air Pollution

    Science.gov (United States)

    ... States Environmental Protection Agency Search Search Lead (Pb) Air Pollution Share Facebook Twitter Google+ Pinterest Contact Us As ... and protect aquatic and terrestrial ecosystems. Lead (Pb) Air Pollution Lead Air Pollution Basics How does lead get ...

  13. AirPEx: Air Pollution Exposure Model

    OpenAIRE

    Freijer JI; Bloemen HJTh; de Loos S; Marra M; Rombout PJA; Steentjes GM; Veen MP van; LBO

    1997-01-01

    Analysis of inhalatory exposure to air pollution is an important area of investigation when assessing the risks of air pollution for human health. Inhalatory exposure research focuses on the exposure of humans to air pollutants and the entry of these pollutants into the human respiratory tract. The principal grounds for studying the inhalatory exposure of humans to air pollutants are formed by the need for realistic exposure/dose estimates to evaluate the health effects of these pollutants. T...

  14. In a randomized placebo-controlled add-on study orlistat significantly reduced clozapine-induced constipation.

    Science.gov (United States)

    Chukhin, Evgeny; Takala, Pirjo; Hakko, Helinä; Raidma, Mirjam; Putkonen, Hanna; Räsänen, Pirkko; Terevnikov, Viacheslav; Stenberg, Jan-Henry; Eronen, Markku; Joffe, Grigori

    2013-03-01

    Constipation is a common and potentially fatal side effect of clozapine treatment. Another important side effect of clozapine may also be significant weight gain. Orlistat is a weight-control medication that is known to induce loose stools as a common side effect. This study aimed to explore whether orlistat used to control clozapine-induced weight gain can simultaneously tackle clozapine-related constipation. In this 16-week randomized-controlled study, clozapine-treated patients received add-on orlistat (n=30) or add-on placebo (n=24). Colonic function was measured using the Bristol Stool Form Scale. There was a significant (P=0.039) difference in the prevalence of constipation in favor of orlistat over placebo in completers (n=40) at the endpoint. A decrease in the prevalence of constipation within the orlistat group (P=0.035) was observed (vs. no statistically significant changes in the placebo group). In clozapine-treated patients, orlistat may be beneficial not only for weight control but also as a laxative. As no established treatments for clozapine-induced constipation exist, orlistat can be considered for this population, although more studies are required.

  15. Analysis of Performance Limitations in Fiber Bragg Grating Based Optical Add-Drop Multiplexer due to Crosstalk

    Directory of Open Access Journals (Sweden)

    Md. Mahiuddin

    2012-03-01

    Full Text Available Abstract— Wavelength  division  multiplexing  (WDM optical networks  are  attracting  more  and  more attention because of their ability to provide  increased capacity and  flexibility. Optical add-drop multiplexer (OADM  becomes  a  key  component  to  add  or  drop wavelengths  in  high  bit  rate  optical  networks. Crosstalk  in OADM  often degrades  the performance of WDM  system  drastically.  In  this  article,  we  have developed  analytical model  for  low  crosstalk  of  fiber Bragg  grating  based  OADM  with  isolator. We  have also  derived  analytical  expressions  for  relative intensity noise (RIN, bit error rate (BER and power penalty to evaluate the performance limitations of this OADM. Results show that crosstalk, RIN and BER of the  proposed  OADM  are significantly  lower  and provide better performance than the existing OADMs.

  16. Omega-3 fatty acids decreased irritability of patients with bipolar disorder in an add-on, open label study

    Directory of Open Access Journals (Sweden)

    Baldassano Claudia F

    2005-02-01

    Full Text Available Abstract This is a report on a 37-patient continuation study of the open ended, Omega-3 Fatty Acid (O-3FA add-on study. Subjects consisted of the original 19 patients, along with 18 new patients recruited and followed in the same fashion as the first nineteen. Subjects carried a DSM-IV-TR diagnosis of Bipolar Disorder and were visiting a Mood Disorder Clinic regularly through the length of the study. At each visit, patients' clinical status was monitored using the Clinical Monitoring Form. Subjects reported on the frequency and severity of irritability experienced during the preceding ten days; frequency was measured by way of percentage of days in which subjects experienced irritability, while severity of that irritability was rated on a Likert scale of 1 – 4 (if present. The irritability component of Young Mania Rating Scale (YMRS was also recorded quarterly on 13 of the 39 patients consistently. Patients had persistent irritability despite their ongoing pharmacologic and psychotherapy. Omega-3 Fatty Acid intake helped with the irritability component of patients suffering from bipolar disorder with a significant presenting sign of irritability. Low dose (1 to 2 grams per day, add-on O-3FA may also help with the irritability component of different clinical conditions, such as schizophrenia, borderline personality disorder and other psychiatric conditions with a common presenting sign of irritability.

  17. Lacosamide as add-on treatment of focal symptomatic epilepsy in a patient with alcoholic liver cirrhosis

    Directory of Open Access Journals (Sweden)

    A. Romigi

    2014-01-01

    Full Text Available The occurrence of epileptic seizures in the presence of hepatic disease is not uncommon in clinical practice. Selecting an appropriate AED for patients affected by liver failure who have new-onset epileptic seizures can be challenging. We describe a 64-year-old man affected by liver cirrhosis. The patient developed partial epilepsy with secondary generalization because of an intracerebral hemorrhage in the left parieto-occipital regions. After the neurosurgery procedure, seizures reappeared and were initially managed with levetiracetam. After one month, the patient experienced clusters of seizures while on stable treatment with levetiracetam. Pregabalin as add-on was not tolerated; therefore, he received a low dose of phenobarbital as add-on treatment. The patient developed hepatic encephalopathy. Phenobarbital was immediately stopped, and oral lacosamide was added. A rapid recovery of encephalopathy with a 6-month seizure freedom was obtained. The patient died 6 months later because of progressive impairment of liver function. Lacosamide may represent an alternative to other AEDs in patients with liver failure; however, further prospective evaluation of its efficacy and safety in this clinical setting is needed.

  18. Antidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic Patients

    Directory of Open Access Journals (Sweden)

    V. T. T. Huyen

    2012-01-01

    Full Text Available Aims. To investigate the antidiabetic effect of the traditional Vietnamese herb Gynostemma pentaphyllum (GP together with sulfonylurea (SU in 25 drug-naïve type 2 diabetic patients. Methods. After 4-week treatment with gliclazide (SU, 30 mg daily, all patients were randomly assigned into 2 groups to add on GP extract or placebo extract, 6 g daily, during eight weeks. Results. After 4-week SU treatment, fasting plasma glucose (FPG and HbA1C decreased significantly (P<0.001. FPG was further reduced after add-on therapy with 2.9 ± 1.7 and 0.9 ± 0.6 mmol/L in the GP and placebo groups, respectively (P<0.001. Therapy with GP extract also reduced 30- and 120-minute oral glucose tolerance test postload values. HbA1C levels decreased approximately 2% units in the GP group compared to 0.7% unit in the placebo group (P<0.001. Conclusion. GP extract in addition to SU offers an alternative to addition of other oral medication to treat type 2 diabetic patients.

  19. A delay-and-Boolean-ADD imaging algorithm for damage detection with a small number of piezoceramic transducers

    Science.gov (United States)

    Lu, Guangtao; Li, Yourong; Song, Gangbing

    2016-09-01

    The delay-and-sum (DAS) imaging algorithm usually sends an excitation signal at each piezoceramic transducer and obtains a defect image by using transmitter-sensor pair signals to draw ellipses or hyperbolas. A delay-and-Boolean-ADD (DABA) imaging algorithm is developed for defect detection of plate-like structures with a small number of piezoceramic transducers. This new method requires sending only one excitation signal for each detection, and obtains a better defect image by employing Boolean ADD operation instead of addition or multiplication operation in the DAS algorithm. A reflection coefficient is introduced in the new algorithm to attenuate the signals reflected from the boundary. The widely used envelop-detection method based on Hilbert-transformation is replaced by a new envelop-detection technique based on a local maximum value to increase the accuracy of locating. An additional time shift due to the excitation signal itself is also considered to decrease the location error. The results of the experiments conducted on an aluminum plate indicate that the proposed DABA imaging algorithm combining with the new techniques can detect a bonded mass defect accurately and efficiently.

  20. Establishment of the Brown Widow Spider (Araneae: Theridiidae) and Infestation of its Egg Sacs by a Parasitoid, Philolema latrodecti (Hymenoptera: Eurytomidae), in French Polynesia and the Cook Islands.

    Science.gov (United States)

    Marie, Jérôme; Vetter, Richard S

    2015-11-01

    This paper presents two newly established species for French Polynesia: the invasive brown widow spider, Latrodectus geometricus C. L. Koch, and its potential biocontrol agent, the parasitoid wasp, Philolema latrodecti (Fullaway). The brown widow spider was recorded from the island of Moorea in 2006 and, since that discovery, the occurrence of this species has expanded to two of the five archipelagos of French Polynesia including the main island of Tahiti and four of the Cook Islands. Although the tropical climate contributes to the establishment of L. geometricus, a biotic factor, P. latrodecti, may restrain population from demographic explosion. This eurytomid wasp is present in French Polynesia and is a parasitoid that has been used in biological control of the southern black widow Latrodectus mactans (F.) in Hawaii. This wasp could become a significant limiting factor for L. geometricus distribution on these islands, as it was found in 31% of the Tahitian brown widow spider egg sacs that were dissected. However, thus far, the wasp was only found on Tahiti in association with the brown widow spider. Although the brown widow is generally considered to be less toxic than its black widow relatives, it remains of medical concern in French Polynesia because reactions to its bites can, at times, be severe. The spider remains of public concern because it is a novel species; it has the word widow in its name and dark morphs are mistaken as black widows.

  1. Novel, high-yield red blood cell production methods from CD34-positive cells derived from human embryonic stem, yolk sac, fetal liver, cord blood, and peripheral blood.

    Science.gov (United States)

    Olivier, Emmanuel; Qiu, Caihong; Bouhassira, Eric E

    2012-08-01

    The current supply of red blood cells expressing rare blood groups is not sufficient to cover all the existing transfusion needs for chronically transfused patients, such as sickle cell disease homozygous carriers, because of alloimmunization. In vitro production of cultured red blood cells is slowly emerging as a possible complement to the existing collection-based red blood cell procurement system. The yield of cultured red blood cells can theoretically be maximized by amplifying the stem, progenitor, or precursor compartment. Here, we combined methods designed to expand these three compartments to optimize the yield of cultured red blood cells and found that exposing CD34(+) cells to a short pulse of cytokines favorable for erythroid differentiation prior to stem cell expansion followed by progenitor expansion produced the highest yield of erythroid cells. This novel serum-free red blood cell production protocol was efficient on CD34(+) cells derived from human embryonic stem cells, 6-8-week yolk sacs, 16-18-week fetal livers, cord blood, and peripheral blood. The yields of cells obtained with these new protocols were larger by an order of magnitude than the yields observed previously. Globin expression analysis by high-performance liquid chromatography revealed that these expansion protocols generally yielded red blood cells that expressed a globin profile similar to that expected for the developmental age of the CD34(+) cells.

  2. Malignant Peripheral Nerve Sheath Tumor in the Lesser Sac Masquerading as a Gastrointestinal Stromal Tumor of the Stomach: A Case Report

    Directory of Open Access Journals (Sweden)

    Yeo

    2016-09-01

    Full Text Available A malignant peripheral nerve sheath tumor (MPNST is very rare, representing 3 - 10% of all soft tissue sarcomas. Approximately half of all such tumors are diagnosed in patients with neurofibromatosis type 1 (NF1. The extremities are involved most commonly, and the patient’s age is usually 20 - 50 years. Herein, we present a case of an MPNST that developed sporadically in an unusual location and in an unusually younger patient. A 16-year-old girl presented with dyspepsia and abdominal distension. Computed tomography (CT demonstrated a well-defined mass approximately 12 cm in diameter in the lesser sac. The mass was composed principally of a heterogeneously enhancing solid portion and exhibited some cystic changes. Clinically and radiologically, the mass appeared to be a gastrointestinal stromal tumor of the stomach. The patient underwent exploratory laparotomy and mass excision. The surgical specimen revealed a solid firm mass measuring 13 × 13 × 6 cm. Histopathological and immunohistochemical analyses identified an MPNST. The patient underwent adjuvant chemotherapy but developed local recurrence with peritoneal seeding 8 months after surgery. Despite treatment with a different chemotherapeutic regimen, the disease progressed systemically and the patient died 3 years and 5 months after surgery. The uncommon tumor location and CT findings of our present MPNST case provide valuable information in terms of future clinical diagnoses of this rare but highly malignant disease.

  3. Novel class of spider toxin: active principle from the yellow sac spider Cheiracanthium punctorium venom is a unique two-domain polypeptide.

    Science.gov (United States)

    Vassilevski, Alexander A; Fedorova, Irina M; Maleeva, Ekaterina E; Korolkova, Yuliya V; Efimova, Svetlana S; Samsonova, Olga V; Schagina, Ludmila V; Feofanov, Alexei V; Magazanik, Lev G; Grishin, Eugene V

    2010-10-15

    Venom of the yellow sac spider Cheiracanthium punctorium (Miturgidae) was found unique in terms of molecular composition. Its principal toxic component CpTx 1 (15.1 kDa) was purified, and its full amino acid sequence (134 residues) was established by protein chemistry and mass spectrometry techniques. CpTx 1 represents a novel class of spider toxin with modular architecture. It consists of two different yet homologous domains (modules) each containing a putative inhibitor cystine knot motif, characteristic of the widespread single domain spider neurotoxins. Venom gland cDNA sequencing provided precursor protein (prepropeptide) structures of three CpTx 1 isoforms (a-c) that differ by single residue substitutions. The toxin possesses potent insecticidal (paralytic and lethal), cytotoxic, and membrane-damaging activities. In both fly and frog neuromuscular preparations, it causes stable and irreversible depolarization of muscle fibers leading to contracture. This effect appears to be receptor-independent and is inhibited by high concentrations of divalent cations. CpTx 1 lyses cell membranes, as visualized by confocal microscopy, and destabilizes artificial membranes in a manner reminiscent of other membrane-active peptides by causing numerous defects of variable conductance and leading to bilayer rupture. The newly discovered class of modular polypeptides enhances our knowledge of the toxin universe.

  4. CM5, a Pre-Swarm Comprehensive Geomagnetic Field Model Derived from Over 12 Yr of CHAMP, Orsted, SAC-C and Observatory Data

    Science.gov (United States)

    Sabaka, Terence J.; Olsen, Nils; Tyler, Robert H.; Kuvshinov, Alexey

    2014-01-01

    A comprehensive magnetic field model named CM5 has been derived from CHAMP, Ørsted and SAC-C satellite and observatory hourly-means data from 2000 August to 2013 January using the Swarm Level-2 Comprehensive Inversion (CI) algorithm. Swarm is a recently launched constellation of three satellites to map the Earth's magnetic field. The CI technique includes several interesting features such as the bias mitigation scheme known as Selective Infinite Variance Weighting (SIVW), a new treatment for attitude error in satellite vector measurements, and the inclusion of 3-D conductivity for ionospheric induction. SIVW has allowed for a much improved lithospheric field recovery over CM4 by exploiting CHAMP along-track difference data yielding resolution levels up to spherical harmonic degree 107, and has allowed for the successful extraction of the oceanic M2 tidal magnetic field from quiet, nightside data. The 3-D induction now captures anomalous Solar-quiet features in coastal observatory daily records. CM5 provides a satisfactory, continuous description of the major magnetic fields in the near-Earth region over this time span, and its lithospheric, ionospheric and oceanic M2 tidal constituents may be used as validation tools for future Swarm Level-2 products coming from the CI algorithm and other dedicated product algorithms.

  5. Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint).

    Science.gov (United States)

    Thebault, Philippe; Chirgadze, Dimitri Y; Dou, Zhen; Blundell, Tom L; Elowe, Sabine; Bolanos-Garcia, Victor M

    2012-12-15

    The SAC (spindle assembly checkpoint) is a surveillance system that ensures the timely and accurate transmission of the genetic material to offspring. The process implies kinetochore targeting of the mitotic kinases Bub1 (budding uninhibited by benzamidine 1), BubR1 (Bub1 related) and Mps1 (monopolar spindle 1), which is mediated by the N-terminus of each kinase. In the present study we report the 1.8 Å (1 Å=0.1 nm) crystal structure of the TPR (tetratricopeptide repeat) domain in the N-terminal region of human Mps1. The structure reveals an overall high similarity to the TPR motif of the mitotic checkpoint kinases Bub1 and BubR1, and a number of unique features that include the absence of the binding site for the kinetochore structural component KNL1 (kinetochore-null 1; blinkin), and determinants of dimerization. Moreover, we show that a stretch of amino acids at the very N-terminus of Mps1 is required for dimer formation, and that interfering with dimerization results in mislocalization and misregulation of kinase activity. The results of the present study provide an important insight into the molecular details of the mitotic functions of Mps1 including features that dictate substrate selectivity and kinetochore docking.

  6. A strategic approach for direct recovery and stabilization of Fusarium sp. ICT SAC1 cutinase from solid state fermented broth by carrier free cross-linked enzyme aggregates.

    Science.gov (United States)

    Chaudhari, Sandeep A; Singhal, Rekha S

    2017-05-01

    The major hurdles in commercial exploitation of cutinase (having both esterolytic and lipolytic activities) with potent industrial applications are its high production cost, operational instability and reusability. Although commercially available in immobilized form, its immobilization process (synthesis of support/carrier) makes it expensive. Herein we tried to address multiple issues of production cost, stability, and reusability, associated with cutinase. Waste watermelon rinds, an agroindustrial waste was considered as a cheap support for solid state fermentation (SSF) for cutinase production by newly isolated Fusarium sp. ICT SAC1. Subsequently, carrier free cross-linked enzyme aggregates of cutinase (cut-CLEA) directly from the SSF crude broth were developed. All the process variables affecting CLEA formation along with the different additives were evaluated. It was found that 50% (w/v) of ammonium sulphate, 125μmol of glutaraldehyde, cross-linking for 1h at 30°C and broth pH of 7.0, yielded 58.12% activity recovery. All other additives (hexane, butyric acid, sodium dodecyl sulphate, Trition-X 100, Tween-20, BSA) evaluated presented negative results to our hypothesis. Kinetics and morphology studies confirmed the diffusive nature of cut-CLEA and BSA cut-CLEA. Developed CLEA showed better thermal, solvent, detergent and storage stability, making it more elegant and efficient for industrial biocatalytic process.

  7. AirPEx: Air Pollution Exposure Model

    NARCIS (Netherlands)

    Freijer JI; Bloemen HJTh; Loos S de; Marra M; Rombout PJA; Steentjes GM; Veen MP van; LBO

    1997-01-01

    Analysis of inhalatory exposure to air pollution is an important area of investigation when assessing the risks of air pollution for human health. Inhalatory exposure research focuses on the exposure of humans to air pollutants and the entry of these pollutants into the human respiratory tract. The

  8. Air Pollution Monitoring | Air Quality Planning & Standards ...

    Science.gov (United States)

    2016-06-08

    The basic mission of the Office of Air Quality Planning and Standards is to preserve and improve the quality of our nation's air. To accomplish this, OAQPS must be able to evaluate the status of the atmosphere as compared to clean air standards and historical information.

  9. Evaluation of juicy sac granulation in citrus with low field nuclear magnetic resonance%基于低场核磁共振的柑橘汁胞粒化评级

    Institute of Scientific and Technical Information of China (English)

    王淼; 张晶; 贺妍; 卢嘉; 郭静; 戴超; 王凤忠; 范蓓

    2016-01-01

    为更加准确、客观、快速地评定柑橘汁胞粒化程度,改变目前主要依靠肉眼感官评级的现状。该文进行了机器打分研究,并与感官评价进行了相关分析。该研究将低场核磁成像及磁弛豫时间测试结果与柑橘汁胞含水率及汁胞粒化程度的感官分级等指标相对应,应用于柑橘汁胞粒化程度的人工智能鉴定和识别。相关分析、F 检验和多重比较等数学分析表明,利用低场核磁横向弛豫时间的响应值可有效反应汁胞粒化程度。横向弛豫时间3个峰的响应值与不同汁胞粒化程度柑橘的感官评价等级及汁胞含水率、果实失重率等存在显著相关(P<0.05)或极显著相关(P<0.01)。经成对t检验分析,基于低场核磁建立的汁胞粒化评级模型与评价员得到感官平均评分的评价结果间没有显著差异(P=0.4982sac granulation, which causes Citrus quality to decline in the process of postharvest storage, seriously affects the Citrus’ edible value and commodity value. Using the technical apparatus for automatic recognition and classification of the Citrus with juicy sac granulation has important practical significance and application potentiality. Low field pulsed nuclear magnetic resonance (LF-NMR) analysis is a kind of measurement technology that is growing, due to its advantages of nondestructive measurement, rapidity and good consistency. The degree of juicy sac granulation in Citrus is closely related to the existent form and content of water. The present study, using the LF-NMR to evaluate the juicy sac granulation of Citrus, researched the correlativity between LF-NMR intensity of different form of H2O and degree of juicy

  10. Simvastatin as add-on therapy to interferon β-1a for relapsing-remitting multiple sclerosis (SIMCOMBIN study): a placebo-controlled randomised phase 4 trial

    DEFF Research Database (Denmark)

    Sorensen, Per Soelberg; Lycke, Jan; Erälinna, Juha-Pekka;

    2011-01-01

    Treatment of relapsing-remitting multiple sclerosis with interferon beta is only partly effective. We aimed to establish whether add-on of simvastatin, a statin with anti-inflammatory properties, improves this efficacy.......Treatment of relapsing-remitting multiple sclerosis with interferon beta is only partly effective. We aimed to establish whether add-on of simvastatin, a statin with anti-inflammatory properties, improves this efficacy....

  11. A new species of Homalocerus Schoenherr from the Atlantic coast of the State of São Paulo, Brazil (Coleoptera, Belidae, Belinae, with notes on color pattern and on the sclerites of the internal sac

    Directory of Open Access Journals (Sweden)

    Sergio A. Vanin

    2014-03-01

    Full Text Available A new species of Homalocerus Schoenherr from the Atlantic coast of the State of São Paulo, Brazil (Coleoptera, Belidae, Belinae, with notes on color pattern and on the sclerites of the internal sac. Homalocerus bimaculatus sp. nov. (type locality: Brazil, São Paulo is described and illustrated, and comments on the sclerites of the internal sac of aedeagus and on color pattern are provided. The new species is compared to other similar species of the genus, being distinguished by having three clusters of carmine pubescence on pronotum and two lateral whitish oval spots located slightly before the middle of each elytron. Six species of Homalocerus, including the new one, are known from the State of São Paulo. The previously published identification key for species of Homalocerus is updated to include H. bimaculatus.

  12. Relationship of lowly gestation sac and placenta previa in early pregnancy by ultrasonic diagnosis%超声诊断早期妊娠妊囊位置低下与前置胎盘的关系

    Institute of Scientific and Technical Information of China (English)

    高晓凤

    2013-01-01

    Objective To analyze the relationship of lowly gestation sac and placenta previa through ultrasonic diagnosis of location of gestation sac and if whether is or isn't placenta previa in early pregnancy of 1000 pregnant women, and deal with as soon as possible. Methods The location of gestation sac and if whether is or isn't placenta previa in early pregnancy of 1000 pregnant women collected in our hospital from May 2010 to November 2012 were ultrasonic detected. Results The patients with lowly gestation sac in early pregnancy were 216, and the patients with placenta previa were 78, of all 45 cases with lowly gestation sac combined with placenta previa. The incidence of the patients diagnosed lowly gestation sac in early pregnancy by ultrasonic inspection with placenta previa was higher. Conclusion The possibility of placenta previa is suggested if lowly gestation sac in early pregnancy was fined. So, the decision of prevent miscarriage or termination of pregnancy should be made. Lowly gestation sac in early pregnancy can provide important value for clinical treatment.%  目的通过超声诊断1000例孕妇早期妊娠妊囊的位置以及查看胎盘是否前置,以此进行分析妊囊位置低下和前置胎盘的关系,以便尽快做出各种处理方案。方法收集2010年5月~2012年11月前来我院就诊的1000名孕妇经超声观察孕妇早期妊娠妊囊位置情况,以及孕妇是否发生前置胎盘。结果早期妊娠妊囊位置低下的有216例,此外发生前置胎盘的有78例,其中妊囊位置低下且发生前置胎盘的孕妇共有45例,超声诊断孕妇早期妊娠妊囊位置低下,发生前置胎盘的几率较大。结论发现孕妇早期妊娠妊囊位置低下时,提示前置胎盘的可能性,因而应尽快做出保胎或者终止妊娠的决策,早期妊娠妊囊位置低下为临床治疗提供重要价值。

  13. The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9.

    Science.gov (United States)

    Dhayalan, Arunkumar; Tamas, Raluca; Bock, Ina; Tattermusch, Anna; Dimitrova, Emilia; Kudithipudi, Srikanth; Ragozin, Sergey; Jeltsch, Albert

    2011-06-01

    Mutations in the ATRX protein are associated with the alpha-thalassemia and mental retardation X-linked syndrome (ATR-X). Almost half of the disease-causing mutations occur in its ATRX-Dnmt3-Dnmt3L (ADD) domain. By employing peptide arrays, chromatin pull-down and peptide binding assays, we show specific binding of the ADD domain to H3 histone tail peptides containing H3K9me3. Peptide binding was disrupted by the presence of the H3K4me3 and H3K4me2 modification marks indicating that the ATRX-ADD domain has a combined readout of these two important marks (absence of H3K4me2 and H3K4me3 and presence of H3K9me3). Disease-causing mutations reduced ATRX-ADD binding to H3 tail peptides. ATRX variants, which fail in the H3K9me3 interaction, show a loss of heterochromatic localization in cells, which indicates the chromatin targeting function of the ADD domain of ATRX. Disruption of H3K9me3 binding may be a general pathogenicity pathway of ATRX mutations in the ADD domain which may explain the clustering of disease mutations in this part of the ATRX protein.

  14. The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9

    Science.gov (United States)

    Dhayalan, Arunkumar; Tamas, Raluca; Bock, Ina; Tattermusch, Anna; Dimitrova, Emilia; Kudithipudi, Srikanth; Ragozin, Sergey; Jeltsch, Albert

    2011-01-01

    Mutations in the ATRX protein are associated with the alpha-thalassemia and mental retardation X-linked syndrome (ATR-X). Almost half of the disease-causing mutations occur in its ATRX-Dnmt3-Dnmt3L (ADD) domain. By employing peptide arrays, chromatin pull-down and peptide binding assays, we show specific binding of the ADD domain to H3 histone tail peptides containing H3K9me3. Peptide binding was disrupted by the presence of the H3K4me3 and H3K4me2 modification marks indicating that the ATRX-ADD domain has a combined readout of these two important marks (absence of H3K4me2 and H3K4me3 and presence of H3K9me3). Disease-causing mutations reduced ATRX-ADD binding to H3 tail peptides. ATRX variants, which fail in the H3K9me3 interaction, show a loss of heterochromatic localization in cells, which indicates the chromatin targeting function of the ADD domain of ATRX. Disruption of H3K9me3 binding may be a general pathogenicity pathway of ATRX mutations in the ADD domain which may explain the clustering of disease mutations in this part of the ATRX protein. PMID:21421568

  15. Changes in mouse liver and chicken embryo yolk sac membrane soluble proteins due to an organophosphorous insecticide (OPI) diazinon linked to several noncholinergic OPI effects in mice and chicken embryos.

    Science.gov (United States)

    Seifert, Josef

    2014-11-01

    The objective of this study was to identify proteins in mouse livers and chicken embryo yolk sac membranes whose quantities were altered by an organophosphorous insecticide (OPI) treatment and which might be linked, based on their functionality, to the recognized noncholinergic effects of OPI. Mice and fertile chicken eggs were treated with an OPI representative diazinon. The quantitative changes in mouse liver and chicken embryo yolk sac membrane soluble proteins caused by diazinon were determined by two-dimensional electrophoresis. Proteins whose quantity was affected by diazinon were identified by the mass spectrometry. In mouse livers, the altered levels of several enzymes of glucose metabolism were considered with regards to amelioration of hyperglycemia due to diazinon; the reduced levels of 3-hydroxyanthranilate 3,4-dioxygenase to the changes in the l-tryptophan to NAD metabolism caused by pyrimidinyl and crotonamide OPI; the reduced levels of catalase, peroxiredoxin and superoxide dismutase to OPI-increased lipid and/or kynurenine oxidation, the latter effect resulting also in increased urinary excretion of xanthurenic and kynurenic acids; and an increase in glutathione S-methyltransferase to OPI detoxification. In chicken embryo yolk sac membranes, the reduced availability of procollagen-proline dioxygenase may be the factor in micromelia caused by OPI in chicken embryos.

  16. REACH. Air Conditioning Units.

    Science.gov (United States)

    Garrison, Joe; And Others

    As a part of the REACH (Refrigeration, Electro-Mechanical, Air-Conditioning, Heating) electromechanical cluster, this student manual contains individualized instructional units in the area of air conditioning. The instructional units focus on air conditioning fundamentals, window air conditioning, system and installation, troubleshooting and…

  17. Statistical air quality mapping

    NARCIS (Netherlands)

    Kassteele, van de J.

    2006-01-01

    This thesis handles statistical mapping of air quality data. Policy makers require more and more detailed air quality information to take measures to improve air quality. Besides, researchers need detailed air quality information to assess health effects. Accurate and spatially highly resolved maps

  18. Parametric study of dielectric loaded surface plasmon polariton add-drop filters for hybrid silicon/plasmonic optical circuitry

    Science.gov (United States)

    Dereux, A.; Hassan, K.; Weeber, J.-C.; Djellali, N.; Bozhevolnyi, S. I.; Tsilipakos, O.; Pitilakis, A.; Kriezis, E.; Papaioannou, S.; Vyrsokinos, K.; Pleros, N.; Tekin, T.; Baus, M.; Kalavrouziotis, D.; Giannoulis, G.; Avramopoulos, H.

    2011-01-01

    Surface plasmons polaritons are electromagnetic waves propagating along the surface of a conductor. Surface plasmons photonics is a promising candidate to satisfy the constraints of miniaturization of optical interconnects. This contribution reviews an experimental parametric study of dielectric loaded surface plasmon waveguides ring resonators and add-drop filters within the perspective of the recently suggested hybrid technology merging plasmonic and silicon photonics on a single board (European FP7 project PLATON "Merging Plasmonic and Silicon Photonics Technology towards Tb/s routing in optical interconnects"). Conclusions relevant for dielectric loaded surface plasmon switches to be integrated in silicon photonic circuitry will be drawn. They rely on the opportunity offered by plasmonic circuitry to carry optical signals and electric currents through the same thin metal circuitry. The heating of the dielectric loading by the electric current enables to design low foot-print thermo-optical switches driving the optical signal flow.

  19. Treatment of traumatised refugees with basic body awareness therapy versus mixed physical activity as add-on treatment

    DEFF Research Database (Denmark)

    Nordbrandt, Maja Sticker; Carlsson, Jessica; Lindberg, Laura Glahder

    2015-01-01

    . In clinical studies, physical activity has shown a positive effect on psychiatric illnesses such as depression and anxiety and for patients with chronic pain. However, scientific knowledge about physical activity as part of the treatment for traumatised refugees is very limited and no guidelines exist......-based Cognitive Behavioural Therapy. The first group only receives treatment as usual while the second and the third groups receive either Basic-Body Awareness Therapy or mixed physical activity as add-on treatments. Each physical activity is provided for an individual 1-hour consultation per week......, for the duration of 20 weeks. The study is being conducted at the Competence Centre for Transcultural Psychiatry, Mental Health Centre Ballerup in the Capital Region of Denmark. The primary endpoint of the study is symptoms of Post Traumatic Stress Disorder; the secondary endpoints are depression and anxiety...

  20. [Development of an add-on module for the WHOQOL-BREF on patients with allergic rhinitis].

    Science.gov (United States)

    Wang, Chiu-Hua; Maa, Suh-Hwa; Yang, Sien-Hung; Chen, Ying-Lin; Chen, Wei-Chun

    2008-06-01

    The purpose of this study was to develop an add-on module for the Taiwan-version WHOQOL-BREF for assessing the quality of life of people with allergic rhinitis. A cross-sectional survey design was used. In accordance with the seven steps for the development of population-specific modules of the WHOQOL, the instrument added new items on the basis of opinions of expert groups, including patients, families and physicians, to the Taiwan-version WHOQOL-BREF measure. The new questionnaire, comprising 52 items, was tested on 252 patients with allergic rhinitis. For content validity, each item was significantly correlated with the domain to which it belonged (r= .157-.715, pWHOQOL-BREF for patients with allergic rhinitis is reliable, valid and specific.