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Sample records for aimar rakko diana

  1. Diana Leonard and Materialist Feminism

    Science.gov (United States)

    Jackson, Stevi

    2013-01-01

    This tribute to Diana Leonard focuses on her contribution to materialist feminism, both through bringing the work of key French theorists to the attention of an Anglophone audience and through her own sociological work on the family, marriage and childhood. In so doing it draws attention to the importance of her work as editor and…

  2. Diana Reference Manual. Revision 3,

    Science.gov (United States)

    1983-02-28

    will help the reader to understand DIANA. Section 1. 1. 1 presents those principles that motivated the original design of DIAN. and Section 1. 1. 2...parenthesized node whose offspring was the addition, since ADA’s parsing rules require the parentheses. The motivation for this requirement Is to ease the...3.7. a 41neA~olm S3.I. C, S.1. F] 51. 52 number 3.1, 3.2.8] 33, 33 numw_d [3.2.83e 35 number rep C4.4.0] 43 nummicUteral [4:4.0] 43 ps4 . I.A 46

  3. NSA Diana Wueger Published in Washington Quarterly

    OpenAIRE

    Grant, Catherine L.

    2016-01-01

    National Security Affairs (NSA) News NSA Faculty Associate for Research Diana Wueger has recently had an article titled “India’s Nuclear-Armed Submarines: Deterrence or Danger?” published in the Washington Quarterly.

  4. Modno vsjo! Nosim to, tshto k litsu / Diana Denissova

    Index Scriptorium Estoniae

    Denissova, Diana

    2006-01-01

    Moskva moenädalal näidatud kollektsioonidest. Oma moekollektsioone esitlesid Valentin Judashkin, Igor Saruhhanov, Masha Tsigal, Natasha Glazkova, Diana Dorozhkina, Svetlana Tegin, Liza Romanjuk, Jelena Tshekrizova, Darja Razumihhina, Vjatsheslav Zaitsev

  5. Diana H. Wall, ESA President 1999-2000

    Science.gov (United States)

    Baron, Jill S.; Parsons, A.

    2000-01-01

    A more polite term for workaholic is over-achiever, and Diana Harrison Wall could easily serve as the type specimen for both words. Her ability to multi-task is a great boon for the Ecological Society of America. That characteristic drive has also been essential to Wall’s own personal success, since it pushed her to persevere during the lean years when a woman’s place was NOT in the field or laboratory. Diana is a very strong role model for young ecologists through her enthusiasm for science, her remarkable scientific achievements, and her leadership skills. In addition to advising her many graduate students, Diana-as-role-model has been featured in many news media, including PBS TV shows such as “Horizons” and “Discovery,” National Geographic magazine, and the New York Times. She is highlighted on the ESA Web site: “What Do Ecologists Do? Focus on Ecologists.”

  6. Data analysis with the DIANA meta-scheduling approach

    International Nuclear Information System (INIS)

    Anjum, A; McClatchey, R; Willers, I

    2008-01-01

    The concepts, design and evaluation of the Data Intensive and Network Aware (DIANA) meta-scheduling approach for solving the challenges of data analysis being faced by CERN experiments are discussed in this paper. Our results suggest that data analysis can be made robust by employing fault tolerant and decentralized meta-scheduling algorithms supported in our DIANA meta-scheduler. The DIANA meta-scheduler supports data intensive bulk scheduling, is network aware and follows a policy centric meta-scheduling. In this paper, we demonstrate that a decentralized and dynamic meta-scheduling approach is an effective strategy to cope with increasing numbers of users, jobs and datasets. We present 'quality of service' related statistics for physics analysis through the application of a policy centric fair-share scheduling model. The DIANA meta-schedulers create a peer-to-peer hierarchy of schedulers to accomplish resource management that changes with evolving loads and is dynamic and adapts to the volatile nature of the resources

  7. Success: Richard Dyer on Diana Ross [and Beyond

    NARCIS (Netherlands)

    Kooijman, J.

    2016-01-01

    In June 1982, film scholar Richard Dyer published a two-page essay on African-American star Diana Ross in the journal Marxism Today. Part of Dyer’s essay focuses on the American conception of success and specifically on how Ross is one of the few black artists who has been "allowed" to be such a

  8. Mis hoiab meid kukkumast? / Diana Leesalu ; intervjueerinud Triin Sinissaar

    Index Scriptorium Estoniae

    Leesalu, Diana

    2011-01-01

    EMTA Lavakunstikooli 3. kursusel dramaturgiks õppiv Diana Leesalu rootsi näitekirjaniku Johanna Emanuelssoni näidendi "Vaata, ma kukun" lavastamisest Tallinna Linnateatris, lavastusest. Kunstnik Kaspar Jancis. Mängivad lavakunstikooli üliõpilased ja Tallinna Linnateatri näitlejad

  9. Interview with Contemporary Armenian Writer and Translator Diana Hambardzumyan

    Directory of Open Access Journals (Sweden)

    Beatrice Tottossy

    2016-12-01

    Full Text Available A conversation with Diana Hambardzumyan, a contemporary Armenian writer, translator and lecturer in English Literature at the University of Yerevan, foregrounds a series of significant features of contemporary Armenian literature and the country’s key social and cultural issues. She interconnects current events with the literary memory, highlighting and confirming the Armenian writers’ need to maintain their traditional role as representatives of the cultural will of their people.

  10. Geologic Map of the Diana Chasma Quadrangle (V-37), Venus

    Science.gov (United States)

    Hansen, V.L.; DeShon, H.R.

    2002-01-01

    Introduction The Diana Chasma quadrangle (V-37), an equatorial region between 0° to 25° S. and 150° to 180° E. that encompasses ~8,400,000 km2, is broadly divided into southern Rusalka Planitia in the north, eastern Aphrodite Terra in the central region, and unnamed regions to the south. Geologic mapping constrains the temporal and spatial relations of the major features, which include a tessera inlier, Markham crater, six large coronae (300-675 km diameter), four smaller coronae (150-225 km diameter), Diana and Dali chasmata, a large fracture zone, and southern Rusalka Planitia. Eastern Aphrodite Terra, marked here by large coronae, deep chasmata, and an extensive northeast-trending fracture zone, extends from Atla Regio to Thetis Regio. The large coronae are part of a chain of such features that includes Inari Corona to the west-southwest and Zemina Corona to the northeast. V-37 quadrangle is bounded on the north by Rusalka Planitia and on the south by Zhibek Planitia. International Astronomical Union (IAU) approved and provisional nomenclature and positions for geographic features within Diana Chasma quadrangle are shown on the geologic map. [Note: Atahensik Corona was referred to as Latona Corona in much previously published literature.

  11. IDENTIFICATION OF MYCOBACTERIUM GENAVENSE IN A DIANA MONKEY (CERCOPITHECUS DIANA) BY POLYMERASE CHAIN REACTION AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY.

    Science.gov (United States)

    Kelly, Kathleen M; Wack, Allison N; Bradway, Dan; Simons, Brian W; Bronson, Ellen; Osterhout, Gerard; Parrish, Nicole M; Montali, Richard J

    2015-06-01

    A 25-yr-old Diana monkey (Cercopithecus diana) with a 1.5-yr history of chronic colitis and diarrhea was found to have disseminated granulomatous disease with intralesional acid fast bacilli. Bacilli were identified as Mycobacterium genavense by polymerase chain reaction, sequencing of the 16S-23S ribosomal RNA intergenic spacer (ITS) gene, and mycolic acid analysis by high-performance liquid chromatography. Mycobacterium genavense is a common cause of mycobacteriosis in free-ranging and captive birds. In addition, recognition of opportunistic infection in human immunodeficiency virus-positive patients is increasing. Disease manifestations of M. genavense are similar to Mycobacterium avium complex (MAC) and include fever, wasting, and diarrhea with disseminated disease. Similar clinical signs and lesions were observed in this monkey. Mycobacterium genavense should be considered as a differential for disseminated mycobacterial disease in nonhuman primates as this agent can mimic MAC and related mycobacteria.

  12. Tamarugite from Diana Cave (SW Romania) -first true karst occurrence

    Science.gov (United States)

    Pušcaš, C. M.; Onac, B. P.; Effenberger, H. S.; Povarǎ, I.

    2012-04-01

    Diana Cave is located within the town limits of Baile Herculane (SW Romania) and develops as a 14 m long, westward oriented, unique passage guided by the Diana fault [1]. At the far end of the cave, the thermo-mineral Diana Spring wells forth. In the early 1970s a mine gallery that intersected the cave was created to drain the water into a pumping station and the original cave passage was somewhat altered and reinforced with concrete. Today the concrete and the silty limestone cave walls are heavily corroded by H2SO4 outgassing from the hot water (ca. 50°C) and display abundant gypsum crusts, soggy aggregates of native S, and a variety of more exotic sulfates. Among them, a mineral that has been previously identified in caves only in connection to volcanic activity, either as thermal springs or fumaroles [2]: tamarugite [NaAl(SO4)26H2O]. It was [3] that first mentioned the occurrence of this Na and Al sulfate in Diana Cave, our research aiming to give a detailed description of this mineral, its paragenesis, and mechanisms of precipitation. Recently, tamarugite has also been identified in a sulfuric acid cave from Greece [4]. Along with powder X-ray diffractions coupled with Rietveld refinement, scanning electron microscope, and electron probe micro-analysis, δ18O and δ34S compositions of the sulfate mineral as well as precipitates from the water were analyzed to identify and better constrain the genesis of this rare sulfate. Regrettably, the crystal size of our specimens is inappropriate for identification by means of single crystal X-ray diffraction. Physical and chemical parameters of Diana Spring were as well measured on several occasions. Geochemical analysis suggests that the minute, white tamarugite flakes precipitated in Diana Cave as a result of the interactions between the thermo-mineral water or water vapor and the original limestone bedrock and concrete that blankets the mine gallery. [1] Povara, I., Diaconu, G., Goran, C. (1972). Observations pr

  13. The mythological space in the first poems of Diana Bellessi

    OpenAIRE

    Martínez Cabrera, Erika

    2011-01-01

    In 2002 Diana Bellessi published La rebelión del instante a book in which we can see the first steps of her long poetic wandering. The mystical contemplation of the detail, the look at the past of myth and the transcendent vocation make the first pole of the work of this Argentinean poet. The second one being the desire for change, a historical restlessness, a political nerve that encourages everything. Powered by the double-headed logic, Crucero ecuatorial (1980) traces the long journey of i...

  14. Surveillance and Social Memory: Remembering Princess Diana with CCTV

    Directory of Open Access Journals (Sweden)

    Nicole Falkenhayner

    2016-09-01

    Full Text Available Since the 1990s, surveillance camera images have experienced a function creep from their juridical uses into journalism and entertainment. In these contexts, the images have also become memory media. This article, for the first time, analyses CCTV images, meaning closed circuit surveillance camera images, as memory media and discusses the implications of our use of artefacts of control within a frame of mediated constructions of social memory. The article undertakes this work by analyzing remediations of the CCTV images of Diana Spencer and Dodi Al-Fayed in the Ritz Hotel in Paris on 30 August 1997 in television news and a documentary from 2007 and 2011, respectively. It is shown how social memory of Diana’s death is a contested site, in which the images play a specific role.

  15. AIMAR survey on complex forms of bronchial asthma and COPD, their management and perception of critical issues.

    Science.gov (United States)

    Donner, Claudio F; Visconti, Alberto

    2014-01-01

    The management of patients with complex forms of bronchial asthma and COPD is not usually addressed in the major international guidelines and management documents which exclusively address pure forms. AIMAR thus undertook a survey to obtain information about: a) the perceived frequency of complex forms of asthma/COPD in adult patients and in the elderly; b) patient management regarding the complex forms (focus on therapeutic goals and consequent treatment); c) the management problems perceived in diagnosis, management, monitoring, indices of appropriateness in pharmacological treatment and adherence to treatment. The survey consisted of 18 multiple choice questions, completed by means of a web-based electronic form published in internet. All the data and responses inserted in the system were checked on-line for coherence and completeness directly during the phase of insertion and each participant had one only possibility of participating. The data thus collected were memorized directly within a relational database, based on consolidated open-source MySQL technology, and thus were immediately available for examination also during the course of the survey. Access to the data, mediated by a "back office" system of interrogation and report, enabled constant monitoring of the survey as it was being carried out, as well as extractions and verification, even on smaller data sets. The survey was carried out in the full month of December 2013 and first half of January 2014. A total of 252 questionnaires were collected from the following physician groups: pneumologists (n = 180), general practitioners (GPs) (n = 32), allergologists (n = 8), internal medicine specialists (n = 20), other specialists (n = 12). Complex forms of bronchial asthma and COPD are frequently observed and considered present in variable percentages ranging from about 10% to about 50% of patients visited and considered typical of patients with a previous history of asthma. Risk factors

  16. The AIMAR recommendations for early diagnosis of chronic obstructive respiratory disease based on the WHO/GARD model*.

    Science.gov (United States)

    Nardini, Stefano; Annesi-Maesano, Isabella; Del Donno, Mario; Delucchi, Maurizio; Bettoncelli, Germano; Lamberti, Vincenzo; Patera, Carlo; Polverino, Mario; Russo, Antonio; Santoriello, Carlo; Soverina, Patrizio

    2014-01-01

    to the Italian context; the document of the Agency for Regional Healthcare Services (AGE.NA.S) is a more suited compendium for consultation, and the recent joint statement on integrated COPD management of the three major Italian scientific Associations in the respiratory area together with the contribution of a Society of General Medicine deals prevalently with some critical issues (appropriateness of diagnosis, pharmacological treatment, rehabilitation, continuing care); also the document "Care Continuity: Chronic Obstructive Pulmonary Disease (COPD)" of the Global Alliance against chronic Respiratory Diseases (GARD)-Italy does not treat in depth the issue of early diagnosis. The present document - produced by the AIMAR (Interdisciplinary Association for Research in Lung Disease) Task Force for early diagnosis of chronic respiratory disease based on the WHO/GARD model and on available evidence and expertise -after a general examination of the main epidemiologic aspects, proposes to integrate the above-mentioned existing documents. In particular: a) it formally indicates on the basis of the available evidence the modalities and the instruments necessary for carrying out secondary prevention at the primary care level (a pro-active,'case-finding'approach; assessment of the individual's level of risk of COPD; use of short questionnaires for an initial screening based on symptoms; use of simple spirometry for the second level of screening); b) it identifies possible ways of including these activities within primary care practice; c) it places early diagnosis within the "systemic", consequential management of chronic respiratory diseases, which will be briefly described with the aid of schemes taken from the Italian and international reference documents.

  17. ''DIANA'' - A New, Deep-Underground Accelerator Facility for Astrophysics Experiments

    International Nuclear Information System (INIS)

    Leitner, M.; Leitner, D.; Lemut, A.; Vetter, P.; Wiescher, M.

    2009-01-01

    The DIANA project (Dakota Ion Accelerators for Nuclear Astrophysics) is a collaboration between the University of Notre Dame, University of North Carolina, Western Michigan University, and Lawrence Berkeley National Laboratory to build a nuclear astrophysics accelerator facility 1.4 km below ground. DIANA is part of the US proposal DUSEL (Deep Underground Science and Engineering Laboratory) to establish a cross-disciplinary underground laboratory in the former gold mine of Homestake in South Dakota, USA. DIANA would consist of two high-current accelerators, a 30 to 400 kV variable, high-voltage platform, and a second, dynamitron accelerator with a voltage range of 350 kV to 3 MV. As a unique feature, both accelerators are planned to be equipped with either high-current microwave ion sources or multi-charged ECR ion sources producing ions from protons to oxygen. Electrostatic quadrupole transport elements will be incorporated in the dynamitron high voltage column. Compared to current astrophysics facilities, DIANA could increase the available beam densities on target by magnitudes: up to 100 mA on the low energy accelerator and several mA on the high energy accelerator. An integral part of the DIANA project is the development of a high-density super-sonic gas-jet target which can handle these anticipated beam powers. The paper will explain the main components of the DIANA accelerators and their beam transport lines and will discuss related technical challenges

  18. Muusika / Aimar Ventsel

    Index Scriptorium Estoniae

    Ventsel, Aimar, 1970-

    2005-01-01

    Uutest heliplaatidest "Sandra Sillamaa", "The Concretes", The Juan Maclean "Less Than Human", Joni Mitchell "Songs Of A Prairie Girl", Pedegree "Growing Apart", Shelton San "EP", The Five Corners Quintet "Chasin' The Jazz Gone By", "The Story of Popular Black Music", Foo Fighters "In Your Honor", A "Teen Dance Ordinance"

  19. Popmuusika / Aimar Ventsel

    Index Scriptorium Estoniae

    Ventsel, Aimar, 1970-

    2006-01-01

    Uutest heliplaatidest Amparanoia "La Vida Te Da", "Kui lähed, mine iseendasse", Cyantific "Ghetto Blaster", The Like "Are You Thinkingb What I'm Thinking?", Prince "3121", Lordi "The Arockalypse", "Twisted Disco"

  20. Condolence Books: Language and Meaning in the Mourning for Hillsborough and Diana

    Science.gov (United States)

    Brennan, Michael

    2008-01-01

    This article reports empirical research into public books of condolence signed following two key mourning events within British culture: the 1989 Hillsborough soccer stadium disaster and the death of Diana, Princess of Wales, in 1997. The author suggests that not only do condolence books provide valuable historical record of the way contemporary…

  1. "Deluded and Ruined": Diana Bastian--Enslaved African Canadian Teenager and White Male Privilege

    Science.gov (United States)

    Cooper, Afua

    2017-01-01

    This essay explores the vulnerability of enslaved African Canadian Black women by examining the death of Diana Bastian, an enslaved Black teenager who in 1792 was raped by George More, a member of the Governing Council of Cape Breton, Nova Scotia. Though Bastian begged for assistance during the resultant pregnancy, More denied her such aid and…

  2. DIANA-microT web server: elucidating microRNA functions through target prediction.

    Science.gov (United States)

    Maragkakis, M; Reczko, M; Simossis, V A; Alexiou, P; Papadopoulos, G L; Dalamagas, T; Giannopoulos, G; Goumas, G; Koukis, E; Kourtis, K; Vergoulis, T; Koziris, N; Sellis, T; Tsanakas, P; Hatzigeorgiou, A G

    2009-07-01

    Computational microRNA (miRNA) target prediction is one of the key means for deciphering the role of miRNAs in development and disease. Here, we present the DIANA-microT web server as the user interface to the DIANA-microT 3.0 miRNA target prediction algorithm. The web server provides extensive information for predicted miRNA:target gene interactions with a user-friendly interface, providing extensive connectivity to online biological resources. Target gene and miRNA functions may be elucidated through automated bibliographic searches and functional information is accessible through Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. The web server offers links to nomenclature, sequence and protein databases, and users are facilitated by being able to search for targeted genes using different nomenclatures or functional features, such as the genes possible involvement in biological pathways. The target prediction algorithm supports parameters calculated individually for each miRNA:target gene interaction and provides a signal-to-noise ratio and a precision score that helps in the evaluation of the significance of the predicted results. Using a set of miRNA targets recently identified through the pSILAC method, the performance of several computational target prediction programs was assessed. DIANA-microT 3.0 achieved there with 66% the highest ratio of correctly predicted targets over all predicted targets. The DIANA-microT web server is freely available at www.microrna.gr/microT.

  3. Mida ootavad juhid oma kommunikatsioonipartnerilt? / Diana Veigel, Kristina Laaneots, Reelika Jakubovski ; intervjueerinud Annela Laaneots

    Index Scriptorium Estoniae

    Veigel, Diana

    2016-01-01

    Oma mõtteid koostööst kommunikatsioonipartneritega jagasid intervjuus Statoil Fuel & Retail Eesti AS-i turundusdirektor Diana Veigel, DHL Expressi äriüksuse tegevjuht Eestis Kristina Laaneots ja Luisa Tõlkebüroo juhatuse liige Reelika Jakubovski

  4. DIANA and applications to fermion production in electron-positron annihilation

    International Nuclear Information System (INIS)

    Fleischer, J.; Lorca, A.; Tentyukov, M.

    2004-01-01

    A demonstration of the use of DIANA has been given. As an example, the process e+e-->tt-bar was selected. Recent developments are indicated: automation of momenta distribution, the status of parallelization of FORM jobs, handling of topologies and new features for the implementation of fermions

  5. Tamarugite in the Steam-Condensate Alteration Paragenesis in Diana Cave (SW Romania)

    Science.gov (United States)

    Puscas, C. M.; Onac, B. P.; Effenberger, H. S.; Povară, I.

    2012-12-01

    The double-salt hydrate tamarugite [NaAl(SO4)2 6H2O] is an uncommon mineral in the cave environment, forming as a result of chemical reactions between water and bedrock only under very specific conditions. The Diana Cave hosts a unique tamarugite occurrence, the first one to be reported from a typical karst environment. The cave is located within the limits of Băile Herculane township in the Cerna Mountains, SW Romania. It consists of a 14 m long, westward-oriented single passage, developed along the Diana Fault. In 1974 a concrete-clad mine gallery was created to channel the thermal water (Diana 1+2 Spring) flowing through the cave to a pumping station. The spring's chemical and physical parameters fluctuated through time, averaging 51.98° C, discharge of 0.96 Ls-1, pH of 7.46, 5768.66 ppm TDS, 9303 μScm-1 conductivity, 5.02 salinity. The major chemical components of the thermo-mineral water in Diana Cave are, Na+ (1392.57 ppm), K+ (58.55 ppm), Ca2+ (725.16 ppm), Mg2+ (10.78 ppm), Cl- (3376.83 ppm), and SO42- (92.27 ppm), and H2S (24.05 ppm), with traces of Si, Fe2+, Br+, I-, and Li+. The general air circulation pattern within the cave is fairly simple: cold air from the outside sweeps into the cave along the floor, heats up at the contact with the thermo-mineral water, ascends, and exists the cave along the ceiling. At the contact with the cold walls of the Diana Cave, the hot steam condenses and gives rise to a rich and exotic sulfate-mineral paragenesis (including halotrichite-series minerals, gypsum, bassanite, anhydrite, epsomite, alunite, halite, native sulfur, etc.). The most exotic minerals precipitate at or below the contact between the Tithonic - Neocomian limestone and the overlaying Cretaceous shaly limestone, as a result of steam-condensate alteration. Minerogenetic mechanisms responsible for the peculiar sulfate mineral assemblage in Diana Cave are evaporation, oxidation, hydrolysis, double exchange reactions, and deposition from vapours or

  6. Lesbian (in)visibility in Italian Renaissance culture: Diana and other cases of donna con donna.

    Science.gov (United States)

    Simons, P

    1994-01-01

    Current conceptualizations of sexual identity in the West are not necessarily useful to an historian investigating "lesbianism" in the social history and visual representations of different periods. After an overview of Renaissance documents treating donna con donna relations which examines the potentially positive effects of condemnation and silence, the paper focuses on Diana, the goddess of chastity, who bathed with her nymphs as an exemplar of female bodies preserved for heterosexual, reproductive pleasures. Yet the self-sufficiency and bodily contact sometimes represented in images of this secluded all-female gathering might suggest "deviant" responses from their viewers.

  7. Diana og Kirke. Den klassiske mytes metamorfose i italienske Renæssance

    DEFF Research Database (Denmark)

    Cecchini, Leonardo

    Den klassiske myte har en særlig stilling i det, Aleida Assmann har kaldt kulturelle Gedächtnis. Takket være dens store udbredelse i den vestlige kultur (både i litteratur, kunst og i andre områder), har den en tendens til at virke, snarere end som konkret ”tekst”, som et udbredt kulturel registe...... renæssancekulturen omarbejder den klassiske myte. Som case-stories vil jeg anvende Kirke-myten og ”den mytiske jagt” (Diana og Aktæon) og vise, hvordan de bliver genanvendt, tilpasset og fortolket i tekster af Petrarca, Boccaccio, Machiavelli og Gelli....

  8. Diana Wynne Jones’s Howl’s Moving Castle (1986) or the Story of a New Mythology

    OpenAIRE

    Seda Yavaş

    2015-01-01

    Diana Wynne Jones’s Howl’s Moving Castle (1986) or The Story of a New Mythology Abstract  This paper focuses upon Diana Wynne Jones’s 1986 fantasy novel Howl’s Moving Castle, part of the trilogy including Castle in the Air (1990) and House of Many Ways (2008). Taking place in a utopian land, the story creates a new mythology built upon magic, objects coming to life, no space boundaries and the search for eternal life and the perfect human. As a consequence, the paper will deal with th...

  9. [DianaWeb: a demonstration project to improve breast cancer prognosis through lifestyles].

    Science.gov (United States)

    Villarini, Anna; Villarini, Milena; Gargano, Giuliana; Moretti, Massimo; Berrino, Franco

    2015-01-01

    In the field of cancer prevention, the public ask to be involved more actively in scientific research and in the production of knowledge. This is leading to an increase of participatory projects in the field of epidemiology. Community-based participatory research (CBPR) has received considerable attention in the past 15 years; it is becoming a recognized and important approach in addressing health disparities in cancer prevention. The increasing accessibility of new methods of comparison, discussion and information allows to link a large number of people. The project DianaWeb was born in 2015 at the Department of Predictive Medicine and Prevention of the National Cancer Institute, Milan. This CBPR involves women with diagnosis of breast cancer (BC). DianaWeb communications are based on an interactive online platform developed "ad hoc" (www.dianaweb.org). With very few exceptions, all communication between participants and research team will be on the web. The recruitment is done through Internet, hospitals, physicians, media and word of mouth. Women can join the project independently, under the control of researchers and the aim of the study is to assess whether healthy eating and regular physical activity can improve the quality of life and increase survival rates in women with diagnosis of BC. About 50,000 Italian women with a diagnosis of BC with or without metastasis, local recurrence or second cancers; with in situ or invasive cancer, whatever the disease stage at diagnosis, whatever histological diagnosis, whatever the time elapsed since diagnosis should be recruited in the DianaWeb project. The volunteers are asked to send clinical information about their condition from diagnosis onwards, on their weight and other anthropometric measures, lifestyles and nutrition through online questionnaires. Moreover, the women enrolled in the study, after login, can access evidence-based information and results obtained during the project (individual and whole community

  10. DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows.

    Science.gov (United States)

    Paraskevopoulou, Maria D; Georgakilas, Georgios; Kostoulas, Nikos; Vlachos, Ioannis S; Vergoulis, Thanasis; Reczko, Martin; Filippidis, Christos; Dalamagas, Theodore; Hatzigeorgiou, A G

    2013-07-01

    MicroRNAs (miRNAs) are small endogenous RNA molecules that regulate gene expression through mRNA degradation and/or translation repression, affecting many biological processes. DIANA-microT web server (http://www.microrna.gr/webServer) is dedicated to miRNA target prediction/functional analysis, and it is being widely used from the scientific community, since its initial launch in 2009. DIANA-microT v5.0, the new version of the microT server, has been significantly enhanced with an improved target prediction algorithm, DIANA-microT-CDS. It has been updated to incorporate miRBase version 18 and Ensembl version 69. The in silico-predicted miRNA-gene interactions in Homo sapiens, Mus musculus, Drosophila melanogaster and Caenorhabditis elegans exceed 11 million in total. The web server was completely redesigned, to host a series of sophisticated workflows, which can be used directly from the on-line web interface, enabling users without the necessary bioinformatics infrastructure to perform advanced multi-step functional miRNA analyses. For instance, one available pipeline performs miRNA target prediction using different thresholds and meta-analysis statistics, followed by pathway enrichment analysis. DIANA-microT web server v5.0 also supports a complete integration with the Taverna Workflow Management System (WMS), using the in-house developed DIANA-Taverna Plug-in. This plug-in provides ready-to-use modules for miRNA target prediction and functional analysis, which can be used to form advanced high-throughput analysis pipelines.

  11. DIANA Code: Design and implementation of an analytic core calculus code by two group, two zone diffusion

    International Nuclear Information System (INIS)

    Mochi, Ignacio

    2005-01-01

    The principal parameters of nuclear reactors are determined in the conceptual design stage.For that purpose, it is necessary to have flexible calculation tools that represent the principal dependencies of such parameters.This capability is of critical importance in the design of innovative nuclear reactors.In order to have a proper tool that could assist the conceptual design of innovative nuclear reactors, we developed and implemented a neutronic core calculus code: DIANA (Diffusion Integral Analytic Neutron Analysis).To calculate the required parameters, this code generates its own cross sections using an analytic two group, two zones diffusion scheme based only on a minimal set of data (i.e. 2200 m/s and fission averaged microscopic cross sections, Wescott factors and Effective Resonance Integrals).Both to calculate cross sections and core parameters, DIANA takes into account heterogeneity effects that are included when it evaluates each zone.Among them lays the disadvantage factor of each energy group.DIANA was totally implemented through Object Oriented Programming using C++ language. This eases source code understanding and would allow a quick expansion of its capabilities if needed.The final product is a versatile and easy-to-use code that allows core calculations with a minimal amount of data.It also contains the required tools needed to perform many variational calculations such as the parameterisation of effective multiplication factors for different radii of the core.The diffusion scheme s simplicity allows an easy following of the involved phenomena, making DIANA the most suitable tool to design reactors whose physics lays beyond the parameters of present reactors.All this reasons make DIANA a good candidate for future innovative reactor analysis

  12. Clinton, Diana, ¿dónde se metieron los periódicos serios?

    Directory of Open Access Journals (Sweden)

    Lic. Francisco Javier Acuña Arias

    1999-01-01

    Full Text Available Uno dividió toda la vida los periódicos en dos clases: los amarillistas y los demás. Los demás eran los "serios", es decir, los que uno leía. Pero a raíz del reciente escándalo de Bill Clinton y la cobertura de la muerte aparatosa de Diana de Gales, cabe preguntarse dónde se metieron los periódicos serios. Revistas tan circunspectas como Time y diarios tan reposados como The New York Times se lanzaron a ver quién era más estrepitoso. Total, lo de Clinton no pasó de ser un chisme de pasillo agrandado a crisis de estado por circunstancias picantes.

  13. Crawford, Elisabeth: "Arrhenius: From Ionic Theory to the Greenhouse Effect" (Canton 1996); and Diana Barkan: "Walther Nernst and the Transition to Modern Physical Science" (Cambridge 1999) (book review)

    OpenAIRE

    Peter J. Ramberg

    2000-01-01

    book review of Crawford, Elisabeth: "Arrhenius: From Ionic Theory to the Greenhouse Effect" (Canton 1996); and Diana Barkan: "Walther Nernst and the Transition to Modern Physical Science" (Cambridge 1999)

  14. Sophie's Defense Mechanism in Her Struggle to Break the Curse in Diana Wynne Jones' Howl's Moving Castle

    OpenAIRE

    Perwita, Ratnanggana Ausiyyah Mustika

    2015-01-01

    The experience that young people get has an effect to their personality and their problem solving. This is why older people tend to be more mature than the young people. In Diana Wynne Jones' Howl's Moving Castle, the main character has a development in her personality through experiences. Her experiences lead her to how she solves her problems while she unconsciously uses defense mechanism. In this case, in this study will be analyzed the characteristic of the main character, Sophie, when sh...

  15. Diversity and morphological structure of bacterial communities inhabiting the Diana-Hygieia Thermal Spring (Budapest, Hungary).

    Science.gov (United States)

    Anda, Dóra; Büki, Gabriella; Krett, Gergely; Makk, Judit; Márialigeti, Károly; Erőss, Anita; Mádl-Szőnyi, Judit; Borsodi, Andrea K

    2014-09-01

    The Buda Thermal Karst System is an active hypogenic karst area that offers possibility for the analysis of biogenic cave formation. The aim of the present study was to gain information about morphological structure and genetic diversity of bacterial communities inhabiting the Diana-Hygieia Thermal Spring (DHTS). Using scanning electron microscopy, metal accumulating and unusual reticulated filaments were detected in large numbers in the DHTS biofilm samples. The phyla Actinobacteria, Firmicutes and Proteobacteria were represented by both bacterial strains and molecular clones but phyla Acidobacteria, Chlorobi, Chlorofexi, Gemmatimonadetes, Nitrospirae and Thermotogae only by molecular clones which showed the highest similarity to uncultured clone sequences originating from different environmental sources. The biofilm bacterial community proved to be somewhat more diverse than that of the water sample and the distribution of the dominant bacterial clones was different between biofilm and water samples. The majority of biofilm clones was affiliated with Deltaproteobacteria and Nitrospirae while the largest group of water clones was related to Betaproteobacteria. Considering the metabolic properties of known species related to the strains and molecular clones from DHTS, it can be assumed that these bacterial communities may participate in the local sulphur and iron cycles, and contribute to biogenic cave formation.

  16. In Conexione: a imaginação do sagrado na ciberarte de Diana Domingues

    Directory of Open Access Journals (Sweden)

    Leila Amaral

    2008-06-01

    Full Text Available Tendo como referência os trabalhos da artista plástica Diana Domingues será apresentada uma reflexão sobre a imaginação do sagrado nas artes visuais a partir da interpretação de temas, imagens, materiais e categorias formais que sustentam a linguagem contemporânea quando se trata do corpo em sua relação com as novas tecnologias comunicacionais. O foco da interpretação oferecida recairá sobre o sentido de sagrado (ou daquilo que é espiritual na "arte interativa" dessa artista. Tal sentido refere-se a um estado de comunicação e conectividade ampliada responsável pela expansão da consciência humana, a partir da experimentação pelo corpo da desestabilização de mundos fixos e acabados propiciada pelas novas tecnologias. O que é espiritual e sagrado para essa vertente artística é a "não essencialidade" da vida e do ser humano ou vida como "pura conectividade". É justo isso que se torna aparente através de suas "obras-dispositivos". Por meio delas, a artista explora ritual, performática e esteticamente a capacidade interativa das novas tecnologias na criação de ambientes vivos e na visualização da vida não como ela é, mas como ela pode ser. O que é sagrado é esse poder recebido das tecnologias que, ao serem acionadas por meio da conectividade, fazem aparecer a própria potência humana de intervir no mundo real e de alterar o ambiente. Não é a tecnologia em si mesma que é sagrada, mas a expansão do universo paralela à expansão da consciência por ela possibilitada, através da ampliação das conexões entre sistemas diferentes. O que é espiritual é, então, esse estado constante de transformação da consciência e da criatividade humana para além da subjetividade individual, porque, segundo essa vertente artística, os poderes recebidos pelas novas tecnologias são eles mesmos da ordem do "ultra-humano", de um "sujeito impessoal ultra-subjetivo".Based on the work of the Brazilian plastic artist Diana

  17. Transnacionalism and Liminal Gnosis in “As Brasíadas” (2013,by Diana Menasché

    Directory of Open Access Journals (Sweden)

    Leoné Astride Barzotto

    2016-10-01

    Full Text Available This article brings a Post-Colonial analysis of the poem “As Brasíadas”, written by Diana Menasché. The poem is part of her book Traz o esqueleto que eu ponho a carne (2013 and, through it, the author develops a re-reading process through a contemporary perspective and based on Luís de Camões’ work, Os Lusíadas. Even though she maintains Camões’ epic format, Menasché upgrades the discourse and reveals aspects of transnacionalism and liminal gnosis in her own writing. Thus, I try to demonstrate that, as a Brazilian and as an immigrant in the United States, she builds a hybrid and transborderer literature, highlighted by the inter-American transit of knowledge and by the proposal of a liminal gnosis (epistemology which shows the bonds among nations and emancipatory cultural practices.

  18. THE THIRD MARGIN OF HISTORY. NOTES ON THE TWO FACES OF WAR BY DIANA ANDRINGA AND FLORA GOMES

    Directory of Open Access Journals (Sweden)

    Livia Apa

    2010-11-01

    Full Text Available The essay intends to approach, taking the documentary authored by the Portuguese journalist Diana Andringa and the Guinea producer Flora Gomes as a starting point, the theme of the memories in conflict, and to reflect upon the manners in which the image archives may function in the process of construction of a collective and shared memory. In this sense, the Portuguese documentary in question seems to present a route that passes by the issue of the “war of memories” proposing a common reading of the histories which occurred on the Guinean front during the colonial war; proposing a reading of the facts which stress how, in accordance to what Amílcar Cabral affirmed, the fate of the two sides, in this particular case, Portugal and Guinea- Bissau, were indissolubly connected.

  19. Consideraciones y criterios para la selección de procesos para la mejora: Procesos Diana/Considerations and criteria for the selection of processes for the improvement: Diana processes

    Directory of Open Access Journals (Sweden)

    Alberto Medina-León

    2012-09-01

    Full Text Available Para implementar un procedimiento de Gestión y Mejora de Procesos, la literatura muestra una amplia revisión de procedimientos o metodologías, todas coincidentes con la necesidad de seleccionar los procesos a mejorar. La presente investigación hace énfasis en los criterios más comúnmente utilizados en la valoración para la selección del orden en que se realizará la mejora, lo que resultó en la recomendación de los criterios: impacto en los objetivos estratégicos y la repercusión en el cliente en cualquier condición existente; además del impacto a corto plazo, la variabilidad y la repetitividad, en dependencia de las necesidades de la organización. Este proceso de selección se sustenta en la utilización de herramientas como el análisis multivariado, el método Kendall para la selección de los procesos relevantes y la Matriz para la selección de los procesos Diana./There is a wealth of literature on procedures and methodologies for the implementation of a procedure of Process Management and Improvement, and all of them coincide with the need for selecting the processes that are going to be improved. This paper stresses the most commonly used criteria in the appraisal for the selection of the order in which the improvement will be made. As a result, there were recommended the following criteria: impact on the strategic objectives and the repercussion on the customer under any existing condition; as well as the short-term impact, the variability and the repetition, depending on the organization needs. This selection process is based on the utilization of instruments such as the multivariate analysis, the Kendall method for the selection of the relevant processes and the Matrix for the selection of the Diana processes.

  20. Three book about Evenki / Aimar Ventsel

    Index Scriptorium Estoniae

    Ventsel, Aimar, 1970-

    2014-01-01

    Arvustus: Сирина, Анна. Эвенки и эвены с современном мире. Самосознание, природопользование, мировозрение. Moskva: Vostochnaia literature, 2012; Поворознюк, Ольга. Забайкальские эвенки. Социально-экономические и культурные трансформации в XX-XXI. Moskva: IEA RAN, 2011; Safonova, Tatiana, Santha Istvan. Culture contact in Evenki Land. A cybernetic anthropology of the Baikal region. Leiden & Boston: Global Oriental, 2013

  1. Gender disparities in diabetes and coronary heart disease medication among patients with type 2 diabetes: results from the DIANA study

    Directory of Open Access Journals (Sweden)

    Krämer Heike U

    2012-07-01

    Full Text Available Abstract Background Coronary heart disease (CHD is one of the most common long-term complications in people with type 2 diabetes. We analyzed whether or not gender differences exist in diabetes and CHD medication among people with type 2 diabetes. Methods The study was based on data from the baseline examination of the DIANA study, a prospective cohort study of 1,146 patients with type 2 diabetes conducted in South-West Germany. Information on diabetes and CHD medication was obtained from the physician questionnaires. Bivariate and multivariate analyses using logistic regression were employed in order to assess associations between gender and prescribed drug classes. Results In total, 624 men and 522 women with type 2 diabetes with a mean age of 67.2 and 69.7 years, respectively, were included in this analysis. Compared to women, men had more angiopathic risk factors, including smoking, alcohol consumption and worse glycemic control, and had more often a diagnosed CHD. Bivariate analyses showed higher prescription of thiazolidinediones and oral combination drugs as well as of angiotensin-converting enzyme (ACE inhibitors, calcium channel blockers and aspirin in men than in women. After full adjustment, differences between men and women remained significant only for ACE inhibitors (OR = 1.44; 95%-confidence interval (CI: 1.11 – 1.88 and calcium channel blockers (OR = 1.42, 95%-CI: 1.05 – 1.91. Conclusions These findings contribute to current discussions on gender differences in diabetes care. Men with diabetes are significantly more likely to receive oral combination drugs, ACE inhibitors and calcium channel blockers in the presence of coronary heart disease, respectively. Our results suggest, that diabetic men might be more thoroughly treated compared to women. Further research is needed to focus on reasons for these differences mainly in treatment of cardiovascular diseases to improve quality of care.

  2. DianaHealth.com, an On-Line Database Containing Appraisals of the Clinical Value and Appropriateness of Healthcare Interventions: Database Development and Retrospective Analysis.

    Science.gov (United States)

    Bonfill, Xavier; Osorio, Dimelza; Solà, Ivan; Pijoan, Jose Ignacio; Balasso, Valentina; Quintana, Maria Jesús; Puig, Teresa; Bolibar, Ignasi; Urrútia, Gerard; Zamora, Javier; Emparanza, José Ignacio; Gómez de la Cámara, Agustín; Ferreira-González, Ignacio

    2016-01-01

    To describe the development of a novel on-line database aimed to serve as a source of information concerning healthcare interventions appraised for their clinical value and appropriateness by several initiatives worldwide, and to present a retrospective analysis of the appraisals already included in the database. Database development and a retrospective analysis. The database DianaHealth.com is already on-line and it is regularly updated, independent, open access and available in English and Spanish. Initiatives are identified in medical news, in article references, and by contacting experts in the field. We include appraisals in the form of clinical recommendations, expert analyses, conclusions from systematic reviews, and original research that label any health care intervention as low-value or inappropriate. We obtain the information necessary to classify the appraisals according to type of intervention, specialties involved, publication year, authoring initiative, and key words. The database is accessible through a search engine which retrieves a list of appraisals and a link to the website where they were published. DianaHealth.com also provides a brief description of the initiatives and a section where users can report new appraisals or suggest new initiatives. From January 2014 to July 2015, the on-line database included 2940 appraisals from 22 initiatives: eleven campaigns gathering clinical recommendations from scientific societies, five sets of conclusions from literature review, three sets of recommendations from guidelines, two collections of articles on low clinical value in medical journals, and an initiative of our own. We have developed an open access on-line database of appraisals about healthcare interventions considered of low clinical value or inappropriate. DianaHealth.com could help physicians and other stakeholders make better decisions concerning patient care and healthcare systems sustainability. Future efforts should be focused on

  3. DianaHealth.com, an On-Line Database Containing Appraisals of the Clinical Value and Appropriateness of Healthcare Interventions: Database Development and Retrospective Analysis.

    Directory of Open Access Journals (Sweden)

    Xavier Bonfill

    Full Text Available To describe the development of a novel on-line database aimed to serve as a source of information concerning healthcare interventions appraised for their clinical value and appropriateness by several initiatives worldwide, and to present a retrospective analysis of the appraisals already included in the database.Database development and a retrospective analysis. The database DianaHealth.com is already on-line and it is regularly updated, independent, open access and available in English and Spanish. Initiatives are identified in medical news, in article references, and by contacting experts in the field. We include appraisals in the form of clinical recommendations, expert analyses, conclusions from systematic reviews, and original research that label any health care intervention as low-value or inappropriate. We obtain the information necessary to classify the appraisals according to type of intervention, specialties involved, publication year, authoring initiative, and key words. The database is accessible through a search engine which retrieves a list of appraisals and a link to the website where they were published. DianaHealth.com also provides a brief description of the initiatives and a section where users can report new appraisals or suggest new initiatives. From January 2014 to July 2015, the on-line database included 2940 appraisals from 22 initiatives: eleven campaigns gathering clinical recommendations from scientific societies, five sets of conclusions from literature review, three sets of recommendations from guidelines, two collections of articles on low clinical value in medical journals, and an initiative of our own.We have developed an open access on-line database of appraisals about healthcare interventions considered of low clinical value or inappropriate. DianaHealth.com could help physicians and other stakeholders make better decisions concerning patient care and healthcare systems sustainability. Future efforts should be

  4. Papel de la Vitamina D en la postmenopausia. Influencia de la suplementación en el metabolismo óseo y otras dianas.

    OpenAIRE

    Arribas Ferriol, Gemma

    2015-01-01

    Actualmente existe un problema de salud mundial con la osteoporosis postmenopáusica y entre los determinantes de salud ósea está un nivel adecuado de vitamina D. También cabe considerar que mantener un nivel adecuado de dicha vitamina influye en otras dianas determinantes en la salud en la postmenopausia, como es el nivel de lípidos, glucemia e insulina, tensión arterial o peso. Entre las tácticas recomendadas por las guías de práctica clínica se contempla la suplementación universal con v...

  5. Caracterización del efecto anticanceroso e identificación de dianas moleculares de principios activos procedentes de "Serratia marcescens"

    OpenAIRE

    Soto Cerrato, Vanessa

    2007-01-01

    Este trabajo de tesis presenta la caracterización del efecto anticanceroso y la identificación de dianas moleculares de principios activos procedentes de la bacteria "Serratia marcescens". En particular, se ha evaluado la capacidad anticancerosa "in vitro" y "ex vivo" del ciclodepsipéptido serratamolide (AT514) en varias células cancerosas y no cancerosas de diverso origen tisular, obteniendo una mayor sensibilidad al tratamiento por parte de las células cancerosas. También hemos realizado es...

  6. Repercusión de algunos factores de riesgo sobre el daño a órganos diana en pacientes hipertensos

    Directory of Open Access Journals (Sweden)

    Alaín Alonso Remedios

    Full Text Available Introducción: la hipertensión arterial constituye un factor de riesgo para otras enfermedades, el cual no solo es determinado por las cifras tensionales si no por la aparición de otros factores de riesgo. Objetivo: identificar la relación de los principales factores de riesgo con la aparición de daño en órganos diana en la población hipertensa del consultorio 5 del área de salud de Rodas. Métodos: se realizó un estudio descriptivo de correlación. Para ello se encuestaron 324 pacientes que cumplieron los criterios de inclusión. Se analizaron variables como: sexo, edad, color de la piel, estado nutricional, valores de colesterol, triglicéridos, glicemia y daño en órganos diana. Se utilizó el SPSS. Los resultados se expresaron en tablas. Resultados: hubo un ligero predominio del sexo femenino (51,9 %, además de un incremento proporcional de la hipertensión arterial y la edad de los pacientes, así como el predominio de los pacientes blancos (75,9 %. La población estudiada tiende al sobrepeso (IMC de 26.9 Desv típ. 3,53 kg/m², además de presentar valores promedios de colesterol de 5,08 Desv típ 1,05 mmol/l y triglicéridos de 2,09 Desv típ 0,84 mmol/l, los valores de glucemia en sangre venosa fueron de 5,5 mmol/l Desv típ 1,22 mmol/l. El incremento de la edad, el sobrepeso, así como de los valores de glucemia, colesterol y triglicéridos se asocian con la aparición de daño en órganos diana (V de Cramer 0,21; 0,97; 0,92; 0,99; 0,94. todos mayores que el nivel de significación. Conclusiones: los factores de riesgos encontrados, en su mayoría, incrementaron el riesgo de presentar daño en órganos diana de los pacientes estudiados.

  7. The Psychology of Music, editado por Diana Deutsch, 3ª edição: resenha dos capítulos 10 a 13

    Directory of Open Access Journals (Sweden)

    Ricieri Carlini Zorzal

    2016-03-01

    Full Text Available O presente texto traz uma resenha de quatro capítulos da terceira edição do livro The Psychology of Music, editado por Diana Deutsch. Nominalmente, são analisados os seguintes capítulos: 10 Performance musical: movimento e coordenação, de autoria de Caroline Palmer; 11 Desenvolvimento musical, de autoria de Laurel Trainor e Erin Hannon; 12 Música e habilidades cognitivas, de autoria de Glenn Schellenberg e Michael Weiss; e 13 As fundações biológicas da música: insights da amusia congênita, de autoria de Isabelle Peretz.

  8. Book Review: Diana Preston, A Higher Form of Killing: Six Weeks in World War I That Forever Changed the Nature of Warfare, New York: Bloomsbury Press, 2015

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    Zachary Wise

    2017-05-01

    Full Text Available A Higher Form of Killing: Six Weeks in World War I That Forever Changed the Nature of Warfare is an awe-inspiring account of the role technology played in one of the largest conflicts of the twentieth century thus reflecting on both political and social history of World War I. Diana Preston demonstrates the ethical impact of warfare while providing a concise analysis of the three most influential technological advances that revolutionized World War I: the development of chlorine gas, the Unterseeboots or U-boats, and the Zeppelin.

  9. Detección de lesión de órgano diana y rigidez arterial mediante monitorización de la presión arterial en 24 horas y frecuencia cardiaca en pacientes hipertensos

    OpenAIRE

    García García, Ángel

    2013-01-01

    [ES] Las enfermedades cardiovasculares son la primera causa de morbi-mortalidad en los países desarrollados y la hipertensión arterial es el principal factor de riesgo para su aparición. Es responsable del 54% de los ictus y del 47% de las cardiopatías isquémicas y, un retraso en su diagnóstico y tratamiento, conlleva a la aparición de lesiones de órganos diana. La lesión de órgano diana renal se evalúa con la creatinina plasmática, la tasa de filtrado glomerular o la microalbuminuria;...

  10. 'Our queen of hearts' - the glorification of Lady Diana Spencer: a critical appraisal of the glorification of celebrities and new pilgrimage

    Directory of Open Access Journals (Sweden)

    Céline Grünhagen

    2010-01-01

    Full Text Available Religiosity and spirituality respectively have always been and will be subject to change. The emergence of the manifold forms of new religious and spiritual movements in the last century includes a variety of cult-like vener­ations of specific individuals, such as politicians (e.g. Mao, Lenin and modern idols (e.g. Elvis Presley, Princess Diana, Michael Jackson, who are glorified like saints. Devotees gather annually for memorials of their departed idols or travel­ long distances to visit the tomb, former home, etc. of a specific person to pay tribute to him or her. Due to the motivations of these devotees, the trouble they take, the practices and the tangible emotionality that are connected with this phenomenon, it can be considered a form of pilgrimage. This article presents some thoughts about the glorification of celebrities which leads to these considerable forms of cult and pilgrimage, using as an example the case of Lady Diana Frances Spencer (d. 1997.

  11. La reconstrucción de una ciudad: la restauración del Templo de Diana de Évora

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    María Cátedra

    2011-09-01

    Full Text Available Este artículo refleja un momento clave de la elaboración simbólica de la ciudad-museo de Évora, en la actualidad Patrimonio de la Humanidad. A partir de la restauración del Templo de Diana en el siglo XIX, los eborenses se apercibieron visual y cognitivamente del origen romano de la ciudad y el monumento, que la corona en su zona más elevada, reestructuró el conjunto de la ciudad y sirvió para reconstruir la imagen posterior. Es una imagen que identificará la ciudad, se convertirá en su exlibris y marcará su historia. Tras un turbulento proceso, los afanes de sus cultos defensores motivaron otras iniciativas posteriores, creando un pionero ambiente de protección y defensa de la ciudad que la caracteriza.

  12. Geologic framework and hydrogeologic characteristics in the southern part of the Rancho Diana Natural Area, northern Bexar County, Texas, 2008-10

    Science.gov (United States)

    Clark, Allan K.; Morris, Robert R.

    2011-01-01

    The area designated by the city of San Antonio as the Rancho Diana Natural Area is in northern Bexar County, near San Antonio, Texas. During 2008-10, the U.S. Geological Survey, in cooperation with the city of San Antonio, documented the geologic framework and mapped the hydrogeologic characteristics for the southern part of the Rancho Diana Natural Area. The geologic framework of the study area and its hydrogeologic characteristics were documented using field observations and information from previously published reports. Many of the geologic and hydrogeologic features were found by making field observations through the dense vegetation along gridlines spaced approximately 25 feet apart and documenting the features as they were located. Surface geologic features were identified and hydrogeologic features such as caves, sinkholes, and areas of solutionally enlarged porosity were located using hand-held Global Positioning System units. The location data were used to create a map of the hydrogeologic subdivisions and the location of karst features. The outcrops of the Edwards and Trinity aquifer recharge zones were mapped by using hydrogeologic subdivisions modified from previous reports. All rocks exposed within the study area are of sedimentary origin and Lower Cretaceous in age. The valley floor is formed in the cavernous member of the upper Glen Rose Limestone of the Trinity Group. The hills are composed of the basal nodular member, dolomitic member, Kirschberg evaporite member, and grainstone member of the Kainer Formation of the Edwards Group. Field observations made during this study of the exposed formations and members indicate that the formations and members typically are composed of mudstones, wackestones, packstones, grainstones, and argillaceous limestones, along with marls. The upper Glen Rose Limestone is approximately 410 to 450 feet thick but only the upper 70 feet is exposed in the study area. The Kainer Formation is approximately 255 feet thick in

  13. High-efficiency improvement for high energy resolution experimental mode of DIANA spectrometer at materials and life science facility (MLF) of J-PARC

    International Nuclear Information System (INIS)

    Takahashi, Nobuaki; Shibata, Kaoru; Arai, Masatoshi; Sato, Taku J.

    2006-09-01

    DIANA is an indirect-geometry time-of-flight (TOF) spectrometer which is planed to install at Materials and Life science Facility (MLF) of Japan Proton Accelerator Research Complex (J-PARC). It has three exchangeable analyzer crystals, such as PG(002), Ge(311) and Si(111) for different energy transfer, momentum transfer and energy-resolution experiments. Normal experimental mode, either PG(002) or Ge(311) analyzer is used, shows moderate energy resolutions of 15μeV or 41λeV, respectively. We are especially aiming very high energy-resolution of 2 μeV by using Si(111) analyzer crystal together with high speed counter-rotating pulse-shaping choppers with each rotation frequency of 300 Hz as an optional setting for the spectrometer. Although such a high energy-resolution is attained, it is considerably inefficient having a very narrow incident energy (E i ) band if the pulse shaping chopper has only one slit. Therefore, we have designed multiple-slit chopper and have performed Monte-Carlo simulation to study Repetition Rate Multiplication (RRM) capability. RRM has been shown to be achievable by using multiple-slit pulse-shaping choppers. By the consideration of the contamination appeared between the neighbor two pulse-shaped bands, the number of slits has been optimized to eight. By using the 8-slit choppers, 23 pulse-shaped neutron energy bands have been available simultaneously within one measurements. Minimum 10 measurements with different phases of the choppers provide the continuous S(Q, ℎω) spectrum of -1.0 meV<ℎω<+3.4 meV. (author)

  14. The influence of environmental parameters in the biocolonization of the Mithraeum in the roman masonry of casa di Diana (Ostia Antica, Italy).

    Science.gov (United States)

    Scatigno, C; Moricca, C; Tortolini, C; Favero, G

    2016-07-01

    The microclimatic parameters (Ta, RH, E, and CO2) reflect the indoor quality of the environment. Their relationship, connected with the design of the building, can facilitate the growth of photo/heterotrophic organisms and therefore facilitate the increase of the relative CO2 production. Taking this into account, the impact of biological proliferation in a historical building is discussed for the Mithraeum of "Casa di Diana" in the archaeological site of Ostia Antica, which is subjected to guided tours. In this work, for the first time, we propose a study on biological monitoring to evaluate the contribution of bioactivity to air quality, with the objective to increase the comfort of visitors and to open the site for more than one day per week, suggesting possible tools providing a good compromise between building conservation and human comfort. In the sense, it has been possible to distinguish the contribution of the plants from the one deriving from humans: high values of carbon dioxide have been recorded during the night and its scarce removal during the day (air flow). The window present is not sufficient to eliminate the CO2, involving concentrations of CO2 relatively high in comparison to the proposed limits and guidelines defined by law. The obtained results strongly encouraged the elimination of flora in order to increase the comfort of visitors and to open the house for more than one day per week. Although, this process involves an important economic effort, the present study allows making an objective decision which has an important value in a cultural heritage management. Graphical Abstract CO2 contribute by bioactivity as damage to human health.

  15. Diana Elvira Soto Arango. La escuela rural en Colombia. Historias de vida de maestras. Mediados del siglo xx. Tunja: fudesa, 2014. 216 páginas.

    Directory of Open Access Journals (Sweden)

    Doris Lilia Torres

    2015-01-01

    Full Text Available Me honra presentar este libro por dos razones: la primera es personal. Porque he tenido el asunto de la identidad del mestizo como una de mis preocupaciones, a través de la cual he tratado de encontrar las voces que hablan sobre lo que somos y cómo somos. Aunque Gabriel García Márquez universalizó nuestra cultura latinoamericana, no me deja de sorprender que cuando los escritores y periodistas de la Costa Atlántica se refieren a su vida y obra, lo hacen de una manera tan personal y cercana, que se siente cómo experimentan ese realismo mágico correr por su venas. De igual manera, leer el libro La Escuela rural en Colombia. Historias de vida de maestra. Mediados del siglo xx, de la Dra. Diana Elvira Soto, hizo que las emociones surgieran y brotaran con las imágenes, símbolos, descripciones y narraciones de las educadoras que vivieron en este altiplano cundiboyacense. Pude sentir el olor de la vereda, el sonido de la quebrada, la soledad de la escuela, lo mitos de la llorona y la patasola escondidos en los rincones de los salones de clase para apaciguar los ánimos, el frío del páramo del Vijagual en Rondón y la frescura del valle de los Ocobos en Miraflores. También sentí la zozobra y el miedo por la violencia y el desplazamiento de Yacopí a Bogotá. Allí la maestra, la mujer, la líder y madre va caminando por las veredas y municipios de una tierra abandonada y asediada por la corrupción política centralista, buscando un ideal y construyendo comunidades que avanzan con la elaboración mental que da el aprendizaje de la lectura y escritura, en manos de maestras como Amparo y Andrea, que creyeron en la construcción de comunidades más justas y menos discriminadas a través de la enseñanza de las letras y el lenguaje.

  16. Model of an innovative and flexible IT company / Aimar Meltsa

    Index Scriptorium Estoniae

    Meltsa, Aimar

    2003-01-01

    Kaanel ajak. ilmumisaeg 2002/2003. Organisatsiooni strateegilise arengu eelduseks on muutusi toetava keskkonna ja organisatsioonikultuuri loomine. Innovaatilise infotehnoloogiaettevõtte mudeli rakendamine. Diagrammid. Skeem

  17. Otvetshajet Diana Ingerainen, vitse-mer Tallinna / Diana Ingerainen

    Index Scriptorium Estoniae

    Ingerainen, Diana, 1971-

    2005-01-01

    Tallinna abilinnapea vastab küsimustele, kuidas perearstikeskused kasutavad endiste polikliinikute ruume ja meditsiiniaparatuuri, kui tihti võtavad perearste abistavad meditsiiniõed vastu patsiente iseseisvalt, millised on perearstide probleemid

  18. Testimonio de la filósofa Diana Maffía sobre el filósofo y jurista Carlos Nino : Ética y derecho para pensar la democracia

    OpenAIRE

    Maffia, Diana Helena; Toschi, Damián

    2013-01-01

    En su programa Derecho de Autor, el periodista Damían Toschi entrevista a la política y filósofa Diana Maffía sobre la figura, influencia y pensamiento de Carlos Nino. Su aporte intelectual a la transición democrática en los años 1982 y 1983, su influencia ética e intelectual en el gobierno de Raúl Alfonsín, en especial en procesos como el juicio a las juntas de gobierno de la dictadura cívico-militar de 1976 a 1983. Carlos Santiago Nino: nació en 1943 en Buenos Aires y murió en 1993. Fue...

  19. High Frequency Data Acquisition System for Modelling the Impact of Visitors on the Thermo-Hygrometric Conditions of Archaeological Sites: A Casa di Diana (Ostia Antica, Italy Case Study

    Directory of Open Access Journals (Sweden)

    Paloma Merello

    2018-01-01

    Full Text Available The characterization of the microclimatic conditions is fundamental for the preventive conservation of archaeological sites. In this context, the identification of the factors that influence the thermo-hygrometric equilibrium is key to determine the causes of cultural heritage deterioration. In this work, a characterization of the thermo-hygrometric conditions of Casa di Diana (Ostia Antica, Italy is carried out analyzing the data of temperature and relative humidity recorded by a system of sensors with high monitoring frequency. Sensors are installed in parallel, calibrated and synchronized with a microcontroller. A data set of 793,620 data, arranged in a matrix with 66,135 rows and 12 columns, was used. Furthermore, the influence of human impact (visitors is evaluated through a multiple linear regression model and a logistic regression model. The visitors do not affect the environmental humidity as it is very high and constant all the year. The results show a significant influence of the visitors in the upset of the thermal balance. When a tourist guide takes place, the probability that the hourly temperature variation reaches values higher than its monthly average is 10.64 times higher than it remains equal or less to its monthly average. The analysis of the regression residuals shows the influence of outdoor climatic variables in the thermal balance, such as solar radiation or ventilation.

  20. High Frequency Data Acquisition System for Modelling the Impact of Visitors on the Thermo-Hygrometric Conditions of Archaeological Sites: A Casa di Diana (Ostia Antica, Italy) Case Study.

    Science.gov (United States)

    Merello, Paloma; García-Diego, Fernando-Juan; Beltrán, Pedro; Scatigno, Claudia

    2018-01-25

    The characterization of the microclimatic conditions is fundamental for the preventive conservation of archaeological sites. In this context, the identification of the factors that influence the thermo-hygrometric equilibrium is key to determine the causes of cultural heritage deterioration. In this work, a characterization of the thermo-hygrometric conditions of Casa di Diana (Ostia Antica, Italy) is carried out analyzing the data of temperature and relative humidity recorded by a system of sensors with high monitoring frequency. Sensors are installed in parallel, calibrated and synchronized with a microcontroller. A data set of 793,620 data, arranged in a matrix with 66,135 rows and 12 columns, was used. Furthermore, the influence of human impact (visitors) is evaluated through a multiple linear regression model and a logistic regression model. The visitors do not affect the environmental humidity as it is very high and constant all the year. The results show a significant influence of the visitors in the upset of the thermal balance. When a tourist guide takes place, the probability that the hourly temperature variation reaches values higher than its monthly average is 10.64 times higher than it remains equal or less to its monthly average. The analysis of the regression residuals shows the influence of outdoor climatic variables in the thermal balance, such as solar radiation or ventilation.

  1. Effects of target location and uncertainty on reaching movements in standing position Los efectos de la ubicación de la diana y la incertidumbre en los movimientos de alcance en la posición vertical Efeitos da localização do alvo e da incerteza em movimentos de alcance na postura ereta

    Directory of Open Access Journals (Sweden)

    Luiz de França Bahia Loureiro Junior

    2012-09-01

    Full Text Available The effects of target location and uncertainty of target position on reaching movements while standing were investigated. Ten healthy, right-handed adults stood facing a 17'' touchscreen. They were instructed to press with their right index fingertip a push bottom and touch the center of the target displayed on the screen after it was lighted on, moving quickly their arm. The target was shown either ipsi- or contralateral to the right arm and either in a certain or uncertain position. Reaction time (RT, movement time (MT, and radial error (RE were assessed. Results revealed shorter RT (≈ 35 ms and smaller RE (≈ 0.19 cm for certain than for uncertain condition and slightly longer RT (≈ 8 ms and MT (≈ 18 ms for reaches towards the contralateral target. In conclusion, the findings of this study showing the effect of uncertainty of target location as well as target position are also applied to arm reaching in standing position.Los efectos de la ubicación de la diana y la incertidumbre acerca de la posición de la diana en los movimientos de alcance fueron investigados. Diez adultos sanos y diestros estaban frente a una pantalla táctil de 17''. Se les instruyó para presionar un interruptor con el dedo índice derecho y tocar el centro de la diana que aparece en la pantalla después de haber sido iluminado, moviéndo rápidamente su miembro superior. La diana fue mostrada ya sea ipsi o contralateralmente y los participantes tenían o no certidumbre sobre la posición de la misma. El tiempo de reacción (TR, el tiempo de movimiento (TM, y el error radial (ER fueron evaluados. Los resultados revelaron ser más cortos TR (≈ 35 ms y RE menor (≈ 0,19cm en la condición de certeza y mayores TR (≈ 8 ms y TM (≈ 18 ms en los movimientos hacia la meta contralateral. En conclusión, los hallazgos de este estudio que muestra los efectos de la incertidumbre de la ubicación de la diana, así como la posición de la diana se aplican también a

  2. DIANA, a program for Feynman Diagram Evaluation

    OpenAIRE

    Tentyukov, M.; Fleischer, J.

    1999-01-01

    Comment: LaTeX, 5 pages, no figures; talk given at 6th International Workshop on Software Engineering, Artificial Intelligence, Neural Nets, Genetic Algorithms, Symbolic Algebra, Automatic Calculation (AIHENP 99), Heraklion, Crete, Greece, 12-16 April, 1999

  3. Análisis del proceso de urgencias y hospitalización del CAMI Diana Tubay a través de un modelo de simulación con Arena 10.0 para la distribución óptima del recurso humano

    OpenAIRE

    Liliana Maria Pantoja Rojas; Luís Antonio Garavito Herrera

    2008-01-01

    Este documento presenta un modelo de simulación que describe el procedimiento actual de Atención del Área de Urgencias y Hospitalización del Centro de Atención Médica Inmediata (CAMI) DIANA TURBAY, Entidad Prestadora de Salud de Primer Nivel de carácter oficial en la ciudad de Bogotá. En el proceso se elaboró una síntesis de estu-dio y registro global de las actividades en las condiciones actuales de atención en el área de Urgencias y Hospitali-zación, así como propuestas que permitieran mejo...

  4. Effect of UV radiation on the genetic inactivation of sperm of the bullseye puffer Sphoeroides annulatus (Jenyns, 1842); Efecto de la radiacion UV en la inactivacion genetica del esperma de botete diana Sphoeroides annulatus (Jenyns, 1842)

    Energy Technology Data Exchange (ETDEWEB)

    Arias-Rodriguez, Lenin; Rodriguez-Ibarra, Luz Estela; Del Valle-Pignataro, Gabriela [Laboratorio de Genetica, Centro de Investigacion en Alimentacion y Desarrollo, A. C., Sinaloa (Mexico)

    2004-09-15

    Genetic (DNA) inactivation of fish sperm with ultraviolet irradiation is generally accompanied by a paradoxical effect on survival rates (Hertwig effect). In the present study, sperm samples from ten males bullseye puffer fish (Sphoeroides annulatus) were diluted 1:50 using Cortland's extender solution and used to test the effect of nine ultraviolet doses (0.2-1.0 J cm{sup -}2 ) on motility time in seconds, motility index, and embryo survival rate after fertilizing eggs from five bullseye puffer females. Motility time of sperm irradiated with 0.2-0.9 J cm{sup -}2 were not statistically different from the controls, but sperm irradiated with a dosage of 1.0 J cm{sup -}2 dosage had significant lower motility time. Motility indices (MI) allowed for the statistical differentiation of four groups in relation to their response to different radiation doses: the first had high MI, and included the controls and 0.2-0.3 J cm{sup -}2 treatments; the second had lower MI and included the 0.4-0.7 J cm{sup -}2 treatments; the third showed recovery of MI and included the 0.8-0.9 J cm{sup -}2 treatments; and the fourth showed the lowest MI with the 1.0 J cm{sup -}2 treatment. Embryo survival was highest for the controls and 0.2 J cm{sup -}2 treatment, decreasing in the 0.3-0.4 J cm{sup -}2 treatments, increasing again in the 0.5-0.8 J cm{sup -}2 treatments, until reaching lowest survival in the 0.9-1.0 J cm{sup -}2 treatments. These results indicate that the best ultraviolet dosage to achieve genetic inactivation of sperm of this species is close to 0.7 J cm{sup -}2, a dosage in which fish fry showed typical haploid syndrome characteristics. [Spanish] La inactivacion genetica (ADN) del esperma de peces se realiza mediante luz ultravioleta que, en irradiaciones crecientes, genera efectos paradojicos (efecto Hertwig) en los porcentajes de supervivencia. En este trabajo se diluyeron muestras de semen provenientes de diez machos de botete diana (Sphoeroides annulatus) en solucion

  5. Siberist Tšetšeeniani Saksa-Vene koostöö nimel / Aimar Ventsel

    Index Scriptorium Estoniae

    Ventsel, Aimar, 1970-

    2005-01-01

    Aprilli keskel käisid Venemaa president Vladimir Putin ja Tšetšeenia asepresident Ramzan Kadõrov visiidil Saksamaal ning külastasid Saksamaa liidukantsleri Gerhard Schröderiga Hannoveri tehnoloogiamessi. Lisa: Kes on Ramzan Kadõrov?

  6. Análisis del proceso de urgencias y hospitalización del CAMI Diana Tubay a través de un modelo de simulación con Arena 10.0 para la distribución óptima del recurso humano

    Directory of Open Access Journals (Sweden)

    Liliana Maria Pantoja Rojas

    2008-01-01

    Full Text Available Este documento presenta un modelo de simulación que describe el procedimiento actual de Atención del Área de Urgencias y Hospitalización del Centro de Atención Médica Inmediata (CAMI DIANA TURBAY, Entidad Prestadora de Salud de Primer Nivel de carácter oficial en la ciudad de Bogotá. En el proceso se elaboró una síntesis de estu-dio y registro global de las actividades en las condiciones actuales de atención en el área de Urgencias y Hospitali-zación, así como propuestas que permitieran mejorar las condiciones de atención a los pacientes y que ayudaran a optimizar los recursos con los que dispone la institución en el área mencionada. Lo anterior se obtuvo contrastando los tiempos de espera, personas en cola y utilización del personal, con la propuesta de estructuración del proce-dimiento del triage presentado por la oficina de Gestión Pública y Autocontrol del Hospital Rafael Uribe Uribe y cu-yo procedimiento se desea implementar en el marco del proyecto de remodelación y ampliación del CAMI. Tam-bién se ensayan diferentes escenarios para evaluar la factibilidad en la reducción de tiempos de espera y número de personas en cola, probando diferentes alternativas de horarios y disposición de recursos de apoyo, con lo cual se muestra una reducción sustancial en los tiempos de atención y de espera de los pacientes.

  7. Eestikeelse loomuliku kõnesünteesi poole / Diana Krull

    Index Scriptorium Estoniae

    Krull, Diana, 1930-2013

    2008-01-01

    Arvustus: Mihkla, Meelis. Kõne ajalise struktuuri modelleerimine eestikeelsele tekst-kõne sünteesile = Modelling the temporal stucture of speech for the Estonian text-to-speech synthesis. Tartu : Tartu Ülikooli Kirjastus, 2007

  8. Gollandskaja KLM natshinajet poljotõ v Amsterdam / Diana King

    Index Scriptorium Estoniae

    King, Diana

    2005-01-01

    Tallinnast alustasid liinilende esmakordselt Eesti turule saabunud lennufirmad: Hollandi KML alustas regulaarlende Tallinn-Amsterdami liinil ning Rootsi tütarfirma Finnair-flyNordic Tallinn-Stockholmi ja Tallinn-Kopenhaageni liinil

  9. Modno vsjo! Nuzhno lish võbrat svojo / Diana Denissova

    Index Scriptorium Estoniae

    Denissova, Diana

    2006-01-01

    Moskva moenädalast. Näidati 50 pret-a-porter kollektsiooni sügis-talveks 2006/07. Valentin Judashkini, Natasha Driganti, Sergei Jefremovi, Vjatsheslav Zaitsevi, Ivan Aiplatovi ja Alena Ahmadulina kollektsioonidest

  10. Elizabeth II üle Diana ja Tony / Kristiina Davidjants

    Index Scriptorium Estoniae

    Davidjants, Kristiina, 1974-

    2007-01-01

    Stephen Frearsi mängufilm "Kuninganna" ("The Queen") : stsenarist Peter Morgan : kuninganna Elizabeth II kehastab Helen Mirren peaminister Tony Blair'i Michael Sheen: Suurbritannia - Ameerika Ühendriigid - Itaalia 2006

  11. A babotshka krõlõshkami... / Diana King

    Index Scriptorium Estoniae

    King, Diana

    2008-01-01

    Oksana Tanditi kollektsiooni Butterflies esitlus Tallinna galeriis Vaal. Kollektsioonis on kunstnik Ruth Tulvingu pildiseeriast "Liblikad" inspireeritud naisterõivad kevad-suveks 2009. 17 värvifotot

  12. Growth potential and growth factor of the IT company operating in Estonia : summary of the study conducted between August-October 2001 / Aimar Meltsa

    Index Scriptorium Estoniae

    Meltsa, Aimar

    2002-01-01

    Kaanel ajak. ilmumisaeg 2001/2002. 2001.a. läbiviidud uuringus vaadeldi Eestis infotehnoloogia vallas tegutsevaid ettevõtteid, eesmärgiga hinnata nende potentsiaalset majanduskasvu ning neid tingimusi, mis seda määravad

  13. Growth potential and growth factor of the IT company operating in Estonia : summary of the study conducted between August-October 2001 / Aimar Meltsa

    Index Scriptorium Estoniae

    Meltsa, Aimar

    2001-01-01

    Kaanel ajak. ilmumisaeg Winter 2001/2002. 2001.a. läbiviidud uuringus vaadeldi Eestis infotehnoloogia vallas tegutsevaid ettevõtteid, eesmärgiga hinnata nende potentsiaalset majanduskasvu ning neid tingimusi, mis seda määravad

  14. Valitsuse poliitika erinõuetega tegevusalade tegevuslubade väljastamisel / Diana Eerma

    Index Scriptorium Estoniae

    Eerma, Diana, 1964-

    2002-01-01

    Tegevusload- ja litsentsid riiklike turutõketena, tegevuslubade kehtestamise eesmärkide analüüs ja tasuvuse hindamise lähtekohad. Tegevuslubadega seotud probleemidest Eestis. Tabelid: turutõkete näiteid; tegevuslubade kehtestamise eesmärgid

  15. U-Pb age of the Diana Complex and Adirondack granulite ...

    Indian Academy of Sciences (India)

    For the most concordant analyses, the 207Pb/206Pb ages range between 1115 and 1150 Ma. Detailed petrographic studies revealed that most grains contained at least two phases of zircon growth, either primary magmatic cores enclosed by variable thickness of metamorphic overgrowths or magmatic portions enclosing ...

  16. "Biennale en scene" keskendus hääle erinevatele võimalustele / Diana Kiivit

    Index Scriptorium Estoniae

    Kiivit, Diana

    2006-01-01

    7. - 26. märtsil Lyonis toimunud festivalist "Biennale en scene" ja seal etendunud kolmest ooperist: G. Aperghis "Entre chien et loup", C. Ambrosini "Il canbto della pelle", P. Dusapini "Faustus, la derniere nuit"

  17. [Delphi consensus on management of dyslipidaemia in patients with impaired glucose metabolism: Diana study].

    Science.gov (United States)

    Pedro-Botet, Juan; Barrios, Vivencio; Pascual, Vicente; Ascaso, Juan F; Cases, Aleix; Millán, Jesús; Serrano, Adalberto; Pintó, Xavier

    2016-01-01

    The aim of the present study was to develop a multidisciplinary consensus based on the Delphi system to establish clinical recommendations for the management of dyslipidaemia when hyperglycaemia is present, and the relevant factors that should be taken into consideration when prescribing and monitoring treatment with statins. The questionnaire developed by the scientific committee included four blocks of questions about dyslipidaemia in patients with impaired glucose metabolism. The results of the first two blocks are presented here: a) management of dyslipidaemia; b) relevant factors that should be taken into consideration when prescribing and monitoring treatment with statins. Among the 497 experts who participated in the study, an agreement of over 90% was attained for recommending screening for dyslipidaemia in patients with diabetes or pre-diabetes and/or cardiovascular disease or a family history and/or abdominal obesity and/or hypertension. There was a high degree of agreement that a statin is the lipid-lowering treatment of choice, and that it should be switched when side effects develop. Also, the choice of statin and dose should be made according to baseline LDL cholesterol levels, the target to achieve, and the possible drug-drug interactions. The screening of dyslipidaemia is primarily conducted in patients with cardiovascular disease, or any major cardiovascular risk factor. When prescribing a statin, physicians mainly focus on the ability to reduce LDL cholesterol and the risk of drug interactions. Copyright © 2016 Sociedad Española de Arteriosclerosis. Published by Elsevier España. All rights reserved.

  18. U-Pb age of the Diana Complex and Adirondack granulite ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    with two of the multi-grain analyses yielded an upper-intercept age of 1118 ± 2.8 Ma and a lower .... Color. Features. Inheritance? 1. 0.040. Euhedral. Clear, slight. Not whole xtal .... visible in this view) without inclusions and metamorphic cores.

  19. DNA-linked Inhibitor Antibody Assay (DIANA) for sensitive and selective enzyme detection and inhibitor screening

    Czech Academy of Sciences Publication Activity Database

    Navrátil, Václav; Schimer, Jiří; Tykvart, Jan; Knedlík, Tomáš; Vik, V.; Majer, Pavel; Konvalinka, Jan; Šácha, Pavel

    2017-01-01

    Roč. 45, č. 2 (2017), č. článku e10. ISSN 0305-1048 R&D Projects: GA MŠk LO1302 Institutional support: RVO:61388963 Keywords : quantitative PCR * enzyme detection * inhibitor screening Subject RIV: CE - Biochemistry OBOR OECD: Biochemical research methods Impact factor: 10.162, year: 2016 https:// academic .oup.com/nar/article-lookup/doi/10.1093/nar/gkw853

  20. Socio-cultural impacts on drug trafficking trends in Europe / Diana S Dolliver

    Index Scriptorium Estoniae

    Dolliver, Diana S

    2015-01-01

    Empiirilisest uuringust, milles analüüsiti neljateistkümnest Euroopa riigist kogutud andmeid aaastatel 1995 kuni 2009. Uuringus keskenduti kanepi, heroiini, kokaiini ja amfetamiiniga kaubitsemisele

  1. Privaatpankur: varastasin miljoneid, aga keegi ei märganud / Lynnley Browning, Diana B. Henriques

    Index Scriptorium Estoniae

    Browning, Lynnley

    2009-01-01

    New Yorgi privaatpankuri, UBSi ja JPMorgan Chase'i varakamate klientide haldurina töötanud Hernan E. Arbizu pettusest, mille käigus võttis ta ebaseaduslikult oma Lõuna-Ameerika klientidelt miljoneid dollareid

  2. Review of 'Game Changers: Education and Information Technologies' (by Diana G. Oblinger)

    OpenAIRE

    McAndrew, Patrick

    2013-01-01

    How can we reach more learners, more effectively, and with greater impact? Education changes lives and societies, but can we sustain the current model? New models and new technologies allow us to rethink many of the premises of education—location and time, credits and credentials, knowledge creation and sharing. Game Changers: Education and Information Technologies is a collection of chapters and case studies contributed by college and university presidents, provosts, faculty, and...

  3. Competition creation and regulation in case of Estonian competition policy / Diana Eerma, Jüri Sepp

    Index Scriptorium Estoniae

    Eerma, Diana, 1964-

    2006-01-01

    Riikliku reguleerimise peaeesmärgiks on suurendada majanduslikku ja sotsiaalset heaolu ning luua makro- ja mikromajanduslik keskkond selleks, et kindlustada ettevõtete konkurentsivõime. Eesti konkurentsipoliitika näitel analüüsitakse konkurentsi loomist ja riiklikku reguleerimist turule sisenemisel

  4. The clinical and integrated management of COPD. An official document of AIMAR (Interdisciplinary Association for Research in Lung Disease), AIPO (Italian Association of Hospital Pulmonologists), SIMER (Italian Society of Respiratory Medicine), SIMG (Italian Society of General Medicine).

    Science.gov (United States)

    Bettoncelli, Germano; Blasi, Francesco; Brusasco, Vito; Centanni, Stefano; Corrado, Antonio; De Benedetto, Fernando; De Michele, Fausto; Di Maria, Giuseppe U; Donner, Claudio F; Falcone, Franco; Mereu, Carlo; Nardini, Stefano; Pasqua, Franco; Polverino, Mario; Rossi, Andrea; Sanguinetti, Claudio M

    2014-01-01

    COPD is a chronic pathological condition of the respiratory system characterized by persistent and partially reversible airflow obstruction, to which variably contribute remodeling of bronchi (chronic bronchitis), bronchioles (small airway disease) and lung parenchyma (pulmonary emphysema). COPD can cause important systemic effects and be associated with complications and comorbidities. The diagnosis of COPD is based on the presence of respiratory symptoms and/or a history of exposure to risk factors, and the demonstration of airflow obstruction by spirometry. GARD of WHO has defined COPD "a preventable and treatable disease". The integration among general practitioner, chest physician as well as other specialists, whenever required, assures the best management of the COPD person, when specific targets to be achieved are well defined in a diagnostic and therapeutic route, previously designed and shared with appropriateness. The first-line pharmacologic treatment of COPD is represented by inhaled long-acting bronchodilators. In symptomatic patients, with pre-bronchodilator FEV1 pulmonary arterial hypertension, cor pulmonale, or edema of the lower limbs or hematocrit > 55%. Respiratory rehabilitation is addressed to patients with chronic respiratory disease in all stages of severity who report symptoms and limitation of their daily activity. It must be integrated in an individual patient tailored treatment as it improves dyspnea, exercise performance, and quality of life. Acute exacerbation of COPD is a sudden worsening of usual symptoms in a person with COPD, over and beyond normal daily variability that requires treatment modification. The pharmacologic therapy can be applied at home and includes the administration of drugs used during the stable phase by increasing the dose or modifying the route, and adding, whenever required, drugs as antibiotics or systemic corticosteroids. In case of patients who because of COPD severity and/or of exacerbations do not respond promptly to treatment at home hospital admission should be considered. Patients with "severe" or "very severe" COPD who experience exacerbations should be carried out in respiratory unit, based on the severity of acute respiratory failure. An integrated system is required in the community in order to ensure adequate treatments also outside acute care hospital settings and rehabilitation centers. This article is being simultaneously published in Sarcoidosis Vasc Diffuse Lung Dis 2014, 31(Suppl. 1);3-21.

  5. 78 FR 6173 - Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and...

    Science.gov (United States)

    2013-01-29

    ... submissions by the parties may be submitted via the Board's e-filing format or in the traditional paper format. Any person using e-filing should attach a document and otherwise comply with the instructions at the E... proceeding under 49 U.S.C. 721 and 5 U.S.C. 554(e). Petitioners request that the Board declare that specific...

  6. 實徵研究/Information Literacy in the Workplace: A Cross-cultural Perspective/Yuhfen Diana Wu

    Directory of Open Access Journals (Sweden)

    Yuhfen Diana Wu Yuhfen Diana Wu

    2012-04-01

    Full Text Available This cross-cultural study has two main purposes: to investigate how information literacy is perceived in the workplace and to discover how employees obtain information to carry out their jobs in an effective and timely fashion. This project applies a mix of research methods, including site visits, interviews, and a survey. More than 120 participants from forty companies were involved in this study. They were from a wide variety of industries in Taiwan and Silicon Valley, in Northern California, where many companies base offices or operations from around the world. Major obstacles in conducting cross-continent research are cost, time demands, scheduling, and adaptation to local culture. In this global economy, cross-cultural and cross-border research will help educators, such as librarians, understand the complexity of skills expected in the workplace. Much has been written on information literacy, yet very few can relate how information literacy is applied in the workplace. This primary study sheds some light to help academic librarians reposition themselves as researchers-educators integral to student success. 本論文為一跨文化性的研究,具有兩個主要目的:一是探討在職場中對於資訊素養的認知;二是探討員工如何及時有效的獲取和應用資訊來執行自己的任務。本研究採用混合式研究方法,包括實地考察、訪談和問卷調查。研究對象來自北加州矽谷和臺灣40家企業的120多名員工,他們分別從事不同行業。其中許多世界級的跨國企業選擇矽谷或臺灣作為公司總部或世界營運樞紐。進行跨洲研究的主要阻礙包括經費、時間、行程安排與適應當地的文化。跨文化和跨國界的研究將有助於教育工作者,如圖書館員,了解職場上所需技能的複雜性。目前已出版許多關於資訊素養的文獻,僅少涉及職場上資訊素養的應用。由於學術圖書館員在學生的學習過程中扮演不可或缺的角色,此初步研究,可幫助學術圖書館員重新為自己定位。 頁次:84-104

  7. DIANA: A Machine Learning Mechanism for Adjusting the TDD Uplink-Downlink Configuration in XG-PON-LTE Systems

    Directory of Open Access Journals (Sweden)

    Panagiotis Sarigiannidis

    2017-01-01

    Full Text Available Modern broadband hybrid optical-wireless access networks have gained the attention of academia and industry due to their strategic advantages (cost-efficiency, huge bandwidth, flexibility, and mobility. At the same time, the proliferation of Software Defined Networking (SDN enables the efficient reconfiguration of the underlying network components dynamically using SDN controllers. Hence, effective traffic-aware schemes are feasible in dynamically determining suitable configuration parameters for advancing the network performance. To this end, a novel machine learning mechanism is proposed for an SDN-enabled hybrid optical-wireless network. The proposed architecture consists of a 10-gigabit-capable passive optical network (XG-PON in the network backhaul and multiple Long Term Evolution (LTE radio access networks in the fronthaul. The proposed mechanism receives traffic-aware knowledge from the SDN controllers and applies an adjustment on the uplink-downlink configuration in the LTE radio communication. This traffic-aware mechanism is capable of determining the most suitable configuration based on the traffic dynamics in the whole hybrid network. The introduced scheme is evaluated in a realistic environment using real traffic traces such as Voice over IP (VoIP, real-time video, and streaming video. According to the obtained numerical results, the proposed mechanism offers significant improvements in the network performance in terms of latency and jitter.

  8. El estrés oxidativo como posible diana terapéutica en la osteoporosis asociada al envejecimiento

    OpenAIRE

    Portal-Núñez, S.; de la Fuente, M.; Díez, A.; Esbrit, P.

    2016-01-01

    La osteoporosis senil o involutiva es un problema de primera magnitud en el mundo desarrollado. Estudios recientes apuntan al aumento del estrés oxidativo asociado al envejecimiento -cronológico o biológico- como un factor importante en su desarrollo. En esta revisión nos centraremos en las alteraciones del tejido óseo con la edad, en el origen del estrés oxidativo y su influencia negativa en el tejido óseo. Finalmente, abordaremos las posibles terapias antiestrés oxidativo que actualmente se...

  9. Mitmekülgne meediaärimees / Toomas Leito ; interv. Urve Vilk

    Index Scriptorium Estoniae

    Leito, Toomas, 1946-

    2008-01-01

    Kolme firma juhatuse liige, Eesti Ajalehtede Liidu tegevdirektor annab ülevaate oma karjäärist meediavaldkonnas ning jagab soovitusi alustavale ettevõtjale. Lisad: Toomas Leito; Edu võtmed. Kommenteerib äripartner Aimar Jugaste

  10. 圖書館事業與交流/The Relationship of Leadership Development and Learning Organization Dimensions/Connie K. Haley, Yuhfen Diana Wu

    Directory of Open Access Journals (Sweden)

    Connie K. Haley, Yuhfen Diana Wu Connie K. Haley, Yuhfen Diana Wu

    2011-10-01

    Full Text Available This research examined the relationship among learning organization dimensions, leadership development, employee development, and their interactions with two demographic variables (gender and ethnicity in the context of libraries. The researchers conducted a multivariate analysis of the variance to assess the differences by leadership training groups (low training hours vs. high training hours, or by gender; and by workplace training groups (low vs. high, or by ethnicity (white vs. all others on a linear combination of the seven dimensions of the learning organization. A conclusive summary is provided along with contributive discussion. Implications and contributions to librarians are discussed in addition to future research recommendations. Also included are conclusive final thoughts accompanied by the limitations of this research. 本研究旨在探討美國圖書館界學習型組織,領導智能與員工發展之間的關系,以及它們與兩項人口變量(性別、種族)的相互作用。作者採用線性組合研究了學習型組織的七個範疇,並且使用多變量變異數分析方法來評估領導智能培訓組的差異(培訓時數多寡對比),在職培訓組的差異(培訓時數多寡對比),及種族的差異(白人或其他族裔對比)。除了討論未來研究方向的建議,作者並提供人力資源發展工作者和圖書館員一些啟示。研究最後提出作者的想法及本研究的侷限性。 頁次:146-165

  11. Muljeid täienduskoolituselt Kanada New Brunswicki Ülikoolis = Impressions of professional training in New Brunswick University, Canada / Diana Maisla

    Index Scriptorium Estoniae

    Maisla, Diana

    1999-01-01

    Õpingutest New Brunswicki Ülikoolis eesti keele kui teise keele õpetamise metoodika arendamise projekti "Estonian Language Training Project" raames. New Brunswicki Ülikool. Rööptekst inglise keeles

  12. Imatinib and gastrointestinal stromal tumor (GIST: a selective targeted therapy Imatinib y tumor del estroma gastrointestinal (GIST: un tratamiento selectivo frente a una diana molecular

    Directory of Open Access Journals (Sweden)

    A. Fernández

    2004-10-01

    Full Text Available Gastrointestinal stromal tumors are the most frequent mesenchymal tumors in the gastrointestinal tract. They originate from the interstitial cells of Cajal and are characterized by an anomalous receptor for a growth factor with tyrosine-kinase activity (c-kit. This anomaly causes a permanent activation of the receptor and uncontrolled cell growth. These tumors show a poor response to traditional chemotherapy drugs, and are thus associated with low survival in cases of advanced disease. Imatinib, a tyrosine kinase inhibitor, is an example of selective targeted oncologic therapy that induces improved survival in these patients. We discuss two cases of metastatic gastrointestinal stromal tumors with a good response to imatinib, and also review the pathophysiology and treatment-related outcome of this type of tumors. We include results from clinical phase-III studies.Los tumores del estroma gastrointestinal son los tumores mesenquimales más frecuentes del tracto digestivo y se originan de las células intersticiales de Cajal. Se caracterizan por presentar un receptor para el factor de crecimiento con actividad tirosin kinasa (c-kit anómalo que condiciona su activación permanente y un crecimiento celular incontrolado. Tienen una baja supervivencia en casos de enfermedad avanzada, con escasa respuesta a los agentes quimioterápicos tradicionales. El imatinib es un fármaco inhibidor de la tirosín kinasa y un ejemplo de terapia oncológica selectiva que condiciona un importante aumento en la supervivencia de estos pacientes. Se presentan 2 casos de enfermedad metastásica con buena respuesta a imatinib, así como una revisión sobre la fisiopatología y evolución en el tratamiento de este tipo de tumores, incluyendo resultados de estudios en fase III.

  13. Van vandag af is jou naam Februarie!' Naamgewing en naam-stroping in tekste van Diana Ferrus, I. D. du Plessis en Rayda Jacobs

    OpenAIRE

    Chaudhari, Shamiega

    2013-01-01

    This article examines naming as the core of identity and how the stripping of a name can lead to the loss of identity. In South African history the colonisation of the Cape Colony since 1 652 is considered the start of forced labour and slavery. Although slavery had a major impact on South African history, limited slave narratives about their personal and life experiences are available. Their identity was hardly of interest to the colonists and it is therefore not surprising that the colonist...

  14. Adenosina y control homeostático del sueño: Acciones en estructuras diana de los circuitos de vigilia y sueño

    OpenAIRE

    Carús-Cadavieco, Marta; Andrés, Isabel de

    2012-01-01

    La homeostasis del sueño se manifiesta ante situaciones de vigilia prolongada de forma natural o experimentalmente. En estos casos, se presenta somnolencia (o presión de sueño) y, cuando se permite dormir, hay un rebote del sueño en duración e intensidad que compensa la pérdida del mismo. Entre las moléculas que pueden intervenir en la regulación homeostática del sueño, se encuentra la adenosina, cuyos antagonistas, la cafeína y la teofilina, consume la población humana ampliament...

  15. Delphi consensus on the diagnosis and management of dyslipidaemia in chronic kidney disease patients: A post hoc analysis of the DIANA study

    Directory of Open Access Journals (Sweden)

    Aleix Cases Amenós

    2016-11-01

    Conclusions: The consensus to analyse the lipid profile in CKD patients suggests acknowledgement of the high cardiovascular risk of this condition. However, the lack of consensus in considering renal function or albuminuria, both when selecting a statin and during follow-up, suggests a limited knowledge of the differences between statins in relation to CKD. Thus, it would be advisable to develop a guideline/consensus document on the use of statins in CKD.

  16. Prurito en un paciente diabético, ¿indicador de lesión de órgano diana?

    Directory of Open Access Journals (Sweden)

    Sonsoles M Velilla-Zancada

    Full Text Available Se presenta el caso de un varón diabético e hipertenso de 71 años de edad, que tiene prurito generalizado, de probable etiología urémica, a consecuencia de un rápido deterioro de la función renal. Una vez modificado el tratamiento, con mejoría del filtrado glomerular y de los niveles de urea en sangre, la clínica desaparece y el paciente permanece asintomático.

  17. Konkurentsipoliitika infrastruktuursetes erandvaldkondades Eesti näitel: loomuliku monopoli ja universaalteenuste põimumine / Jüri Sepp, Diana Eerma

    Index Scriptorium Estoniae

    Sepp, Jüri, 1952-

    2011-01-01

    Artikli eesmärgiks on süstematiseerida ja hinnata erandvaldkondade reguleerimise majanduspoliitilisi meetmeid, kõrvutatakse eri valdkondade lahendusi omavahel ja normatiivse teooria seisukohtadega. Tabel

  18. Diana Auth, Eva Buchholz, Stefanie Janczyk (Hg.: Selektive Emanzipation. Analysen zur Gleichstellungs- und Familienpolitik. Opladen u.a.: Verlag Barbara Budrich 2010.

    Directory of Open Access Journals (Sweden)

    Maria Wersig

    2010-07-01

    Full Text Available Im vorliegenden Sammelband wird die Gleichstellungs- und Familienpolitik der Großen Koalition aus feministisch-politikwissenschaftlichen Perspektiven analysiert. Die Beiträge geben einen Überblick über wichtige politische Entwicklungslinien der letzten Jahre und bieten kritische Perspektiven auf der Grundlage unterschiedlicher methodischer und theoretischer Zugänge. Im Zentrum stehen die Auswirkungen politischer Reformen auf unterschiedliche Gruppen von Frauen und Männern sowie Analysen der Bedeutung der Geschlechterverhältnisse im Zusammenwirken mit anderen Diskriminierungskategorien in politischen Prozessen. Ergänzt werden die Auseinandersetzungen mit dem deutschen Status quo durch drei Beiträge, welche europäische Entwicklungen in ihre Überlegungen einbeziehen.The collected volume at hand analyses equality and family politics of the Grand Coalition from the perspective of feminism and political science. The contributions provide an overview of the important political developments charted in recent years and offer critical perspectives that are based on different methodological and theoretical approaches. Central to the volume are the effects of political reforms on different groups of women and men as well as analyses of the meaning of gender relations in conjunction with other categories of discrimination in political processes. The volume expands on the examination of the German status quo in three contributions, which include also European developments in their considerations.

  19. The Effects of Hypoderma diana Larvae on Antioxidant Ability in Reindeers%鹿皮蝇蛆对驯鹿抗氧化能力的影响

    Institute of Scientific and Technical Information of China (English)

    李云章; 孙博; 古革军; 石丽华

    2012-01-01

    为了探讨驯鹿鹿皮蝇蛆对驯鹿机体氧化应激的影响,分别对鹿皮蝇蛆感染组和未感染组驯鹿血清中的总超氧化物歧化酶(T-SOD)、一氧化氮(NO)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)、羟自由基(·OH)及总抗氧化能力(T-AOC)进行测定.结果表明鹿皮蝇蛆感染组血清中T-SOD、T-AOC活性、抑制·OH能力及NO含量极显著低于未感染组(P<0.01),血清中GSH-Px活性显著低于未感染组(P<0.05);血清中MDA含量极显著高于未感染组(P<0.01).说明驯鹿感染鹿皮蝇蛆后,机体清除自由基能力降低,自由基在机体内大量蓄积,导致机体产生氧化应激反应.

  20. EPIDEMIOLOGICAL INVESTIGATION OF HYPODERMA DIANA IN REINDEERS%驯鹿鹿皮蝇蛆病流行病学调查

    Institute of Scientific and Technical Information of China (English)

    孙博; 李云章; 杨晓野; 古革军; 乌日山

    2010-01-01

    2007年5月至2009年10月,在内蒙古自治区根河市敖鲁古雅鄂温克民族乡分别对708只、445只和498只驯鹿进行了皮蝇幼虫病的流行病学调查.结果表明:该病的病原为双翅目、皮蝇科、皮蝇属的鹿皮蝇的各期幼虫,其成蝇一般在6月初出现,7月~8月为侵袭高峰期,9月末10月初消失.在鄂温克民族乡的驯鹿3a内鹿皮蝇幼虫的平均感染率为22.42%,平均感染强度为16个/只,最高的达98个/只.驯鹿鹿皮蝇幼虫主要寄生于驯鹿的食道、胸腹背皮下等部位,并引起相应部位的炎症.

  1. "Medvezhii" ugol Jevrosojuza / Jevgeni Ashihmin

    Index Scriptorium Estoniae

    Ashihmin, Jevgeni

    2007-01-01

    Regionaalminister Vallo Reimaa, Ida-Virumaa maavanem Riho Breivel, Kirde-Eesti piirivalveülem Aimar Kess, Alajõe vallavanem Natalja Varkki, Vasknarva külavanem Vadim Ivanov ja kohalik aktivist Aleksandr Petuhhov arutasid Alajõe valla ja Vasknarva küla probleeme

  2. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Franck Molina. Articles written in Journal of Biosciences. Volume 32 Issue 1 January 2007 pp 145-155 Articles. Formal TCA cycle description based on elementary actions · Pierre Mazière Nicolas Parisey Marie Beurton-Aimar Franck Molina · More Details Abstract Fulltext PDF.

  3. Piirivalve argipäev: patrullkäigud, hädaabi ja nüüd ...kaaslase otsing / Tanel Mazur

    Index Scriptorium Estoniae

    Mazur, Tanel, 1971-

    2009-01-01

    Kirde piirivalvepiirkonna ülem kolonel Aimar Köss ja Vasknarva kordoni ülem kapten Margo Kaljus räägivad piirivalvuriga juhtunud traagilise õnnetuse taustal piirivalve tööst ja ohtudest. Vt. samas: Piirivalvur jäi tööl kadunuks

  4. Desarrollo de un chip de DNA para la detección de dianas génicas bacterianas de interés en el campo de la acuicultura

    OpenAIRE

    Labella, Alejandro; Trento, I.; Ghidini, V.; Gennari, M.; Castro, D.; Borrego-Garcia, Juan Jose; Lleò, M.M.

    2014-01-01

    La adquisición bacteriana de multiresistencias frente a antimicrobianos es un fenómeno cada vez más preocupante, con gran repercusión para la salud pública, pero también con impacto en sectores de la producción animal, como es el caso particular de la acuicultura. Entre los años 2010-2012, como objetivo de un Proyecto de Investigación Italiano (Progetti d’interesse Nazionale, PRIN), se realizaron diferentes campañas de muestreo a lo largo de la costa del mar Adriático, en centros dedicados a ...

  5. Consenso Delphi sobre el diagnóstico y manejo de la dislipidemia en pacientes con enfermedad renal crónica: análisis post-hoc del estudio DIANA

    Directory of Open Access Journals (Sweden)

    Aleix Cases Amenós

    2016-11-01

    Conclusiones: El consenso en analizar el perfil lipídico en los pacientes con ERC indica el reconocimiento del alto riesgo cardiovascular de esta enfermedad. La ausencia de acuerdo en considerar la función renal o la albuminuria, tanto en la elección de la estatina como durante el seguimiento, indica un conocimiento limitado de las diferencias entre estatinas en relación con la ERC, por lo que sería deseable disponer de una guía/documento de consenso sobre uso de estatinas en la ERC.

  6. Hornbills can distinguish between primate alarm calls.

    Science.gov (United States)

    Rainey, Hugo J.; Zuberbühler, Klaus; Slater, Peter J. B.

    2004-01-01

    Some mammals distinguish between and respond appropriately to the alarm calls of other mammal and bird species. However, the ability of birds to distinguish between mammal alarm calls has not been investigated. Diana monkeys (Cercopithecus diana) produce different alarm calls to two predators: crowned eagles (Stephanoaetus coronatus) and leopards (Panthera pardus). Yellow-casqued hornbills (Ceratogymna elata) are vulnerable to predation by crowned eagles but are not preyed on by leopards and might therefore be expected to respond to the Diana monkey eagle alarm call but not to the leopard alarm call. We compared responses of hornbills to playback of eagle shrieks, leopard growls, Diana monkey eagle alarm calls and Diana monkey leopard alarm calls and found that they distinguished appropriately between the two predator vocalizations as well as between the two Diana monkey alarm calls. We discuss possible mechanisms leading to these responses. PMID:15209110

  7. 75 FR 12174 - Proposed Information Collection; Comment Request; Request for Special Priorities Assistance

    Science.gov (United States)

    2010-03-15

    ... Act, the Selective Service Act and the Defense Priorities and Allocation System regulation. II. Method...: Direct all written comments to Diana Hynek, Departmental Paperwork Clearance Officer, Department of...

  8. Targeting Androgen Receptor in Breast Cancer: Enzalutamide as a Novel Breast Cancer Therapeutic

    Science.gov (United States)

    2016-09-01

    Publications, Abstracts, and Presentations: Papers: Dawn R. Cochrane, Sebastian Bernales, Britta M. Jacobsen, Diana M. Cittelly, Erin N. Howe, Nicholas C...Dawn R. Cochrane, Sebastian Bernales, Britta M. Jacobsen, Diana M. Cittelly, Erin N. Howe, Nicholas C. D’Amato, Nicole S. Spoelstra, Annie Jean

  9. Leader Behavior of Head Nurses through the Perceptions of Self and Others.

    Science.gov (United States)

    1984-01-01

    Diana L. Kuphella. BSN, MEd. The Ohio State Uiversity 1984 Approved by Copyright ()19&1 by Diana Kupohefla. (I Advisor All rights reserved. Department of...Managerial Woman. New York: Doubleday. Hersey, P., & Blanchard, K. (1969). Life cycle theory of leadership. Training and Development Journal, May. Hersey

  10. Full size testing of sheet pile walls

    NARCIS (Netherlands)

    Kuilen, J.W.G. van de; Linden, M.L.R. van der; Katsma, H.; Stolle, P.

    1996-01-01

    Azobé (Lophira alata) is widely used in timber sheet pile walls in the Netherlands. The boards in these walls are coupled and therefore load-sharing can be expected. A simulation model based on the finite element method DIANA (DIANA, 1992) was developed and load-sharing could be calculated. To check

  11. Riski üleminek müügilepingus ÜRO kaupade rahvusvahelise ostu-müügi lepingute konventsiooni ja Eesti võlaõigusseaduse eelnõu alusel : [bakalaureusetöö] / Diana Rammul ; Tartu Ülikool, õigusteaduskond ; juhendaja: Andres Vutt

    Index Scriptorium Estoniae

    Rammul, Diana

    1999-01-01

    Riskist ja riski üleminekust müügilepingus üldiselt, riski ülemineku põhimõtted, ostja kohustused kauba juhusliku kaotsimineku korral, riski üleminek kauba veo korral, riski üleminek vedamisel oleva kauba müügi korral, riski üleminek kauba veota, riski üleminek müüjapoolse lepingu olulise rikkumise korral

  12. 78 FR 41927 - Environmental Impacts Statements; Notice of Availability

    Science.gov (United States)

    2013-07-12

    ..., USFS, CA, Eldorado National Forest Travel Management, Review Period Ends: 08/12/2013, Contact: Diana Erickson 530-621-5214 EIS No. 20130204, Final EIS, NASA, AK, Sounding Rockets Program at Poker Flat...

  13. catherine of siena's wisdom on discernment and her reception

    African Journals Online (AJOL)

    ISSN 1015-8758. © UV/UFS. . Diana L. Villegas E-mail: ..... these lamps to enlighten blind and dense understandings. They ..... and following God's will, she was led to exhort a Pope, to dare to teach him.

  14. 78 FR 279 - Atlantic Highly Migratory Species; 2006 Consolidated Highly Migratory Species Fishery Management...

    Science.gov (United States)

    2013-01-03

    ... conjunction with a state stakeholder meeting being held by the Maryland Department of Natural Resources on......... Houston, TX Clear Lake City-County 5 p.m.-8 p.m Freeman Branch Library, 16616 Diana Lane, Houston, Texas...

  15. Tants ei küsi vanust / Ille Grün-Ots, Siiri Rebane

    Index Scriptorium Estoniae

    Grün-Ots, Ille, 1960-2016

    2007-01-01

    Kanal 2 menusaate "Tantsud tähtedega" järellainetuses vesteldakse artiklis seltskonnatantsust Revalia tantsukooli juhataja Merle Klandorfiga, bailatinost Dance Act direktori Georg Kodusaarega, kõhutantsust tantsuõpetaja Diana Otsinguga ja flamenkost Claudia Shevsthenkoga

  16. Plaadid / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2002-01-01

    Uutest plaatidest David Guetta "Just A Little More Love", Bond "Shine", Chris de Burgh "Timing Is Everything...", Diana Krall "Live In Paris", Richard Ascroft "Human Conditions", Rein Laaneorg "Teine elu", Leaves "Breathe", Derek Trucks Band "Jouful Noise"

  17. Merimetsas uuriti moekunsti ravitoimet / Anne Vetik

    Index Scriptorium Estoniae

    Vetik, Anne

    2006-01-01

    Merimetsa Tugikeskuse erivajadustega kliendid valmistasid rahvusvahelise disainiprojekti raames rõivaid. Tehtud fotodest pannakse kokku moeteraapiat tutvustav näitus. Eestvedajaks kunstnik Sirja-Liisa Vahtra, Pariisis elav fotograaf Diana Lui ja rootsi disainer Otto von Busch

  18. Book Review: "Can NGOs make a difference? The challenge of ...

    African Journals Online (AJOL)

    Anthony J. Bebbington, Samuel Hickey and Diana C. Miltin, eds.,"Can NGOs Make a Difference? The Challenge of Development Alternatives". London, Zed Books, 2008. Reviewed by Kirk D. Helliker Department of Sociology Rhodes University Grahamstown South Africa ...

  19. Torgovlja litshnoi zhiznju / Julia Larina

    Index Scriptorium Estoniae

    Larina, Julia

    2007-01-01

    BBC Worldwide koostöös Venemaa televisiooni Esimese Kanaliga on produtseerinud dokumentaalfilmi "Printsess Diana. Viimane päev Pariisis". Pikemalt filmis peamiseks kujunenud probleemist - staari ja meedia suhetest, ka Venemaa kontekstis

  20. Expedient

    Directory of Open Access Journals (Sweden)

    Fernando de Assis Rodrigues

    2017-07-01

    Full Text Available Expedient of Volume 3, Issue 1 from the year 2017EDITORIAL STAFFEditorsDiana Vilas Boas Souto AleixoFernando de Assis RodriguesEditorial ComissionDiana Vilas Boas Souto AleixoFernando de Assis RodriguesRicardo César Gonçalves Sant’AnaExecutive ComissionPedro Henrique Santos BisiAd hoc peer reviewersAna Carolina Simionato, Universidade Federal de São Carlos (UFSCarDiana Vilas Boas Souto Aleixo, Universidade Estadual Paulista (UNESPElaine Parra Affonso, Faculdade de Tecnologia de Presidente Prudente (FATEC - Universidade Estadual Paulista (UNESPElvio Gilberto da Silva, Universidade do Sagrado Coração (USCFábio Mosso Moreira, Universidade Estadual Paulista (UNESPThais Batista Zanineli, Universidade Estadual de Londrina (UELText reviewersDiana Vilas Boas Souto Aleixo, Universidade Estadual Paulista (UNESPElizabete Cristina de Souza Aguiar Monteiro (UNESP

  1. Plaadid / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2002-01-01

    Uutest plaatidest Suede "A New Morning", Maria Kirsi "Burning Flame", Jüri Homenja "Hommennium III", "Dogtown ans Z-Boys", Diana King "respect", No Angels "Now...Us!", Default "The Fallout", Steve Earle "Jerusalem"

  2. MOOC Blended learning ontwikkelen

    NARCIS (Netherlands)

    Verjans, Steven

    2015-01-01

    Presentatie over het ontwerpen van leeractiviteiten (learning design) tijdens de zesde live sessie van de MOOC Blended learning ontwikkelen. Met gebruikmaking van presentatiematerialen van Diana Laurillard, Grainne Conole, Helen Beetham, Jos Fransen, Pieter Swager, Helen Keegan, Corinne Weisgerber.

  3. Tantsupäev toob publiku ette säravaid balletitähti / Raimu Hanson

    Index Scriptorium Estoniae

    Hanson, Raimu, 1957-

    2006-01-01

    29. apr. esinevad Vanemuises rahvusvaheliselt tuntud tantsijad - Tamara Rojo, Jan-Erik Wikström, Inaki Urlezaga, Anna Valev, Olga Volobujeva, Priit Kripson, Diana Cuni ja Kristoffer Sakurai -, et tähistada rahvusvahelist tantsupäeva

  4. The public of media events

    Directory of Open Access Journals (Sweden)

    Christian Morgner

    2011-06-01

    The article examines different types of semantic inclusion, with a focus on emotional reactions towards three different media events: the Titanic disaster, the assassination of John F. Kennedy, and the death of Princess Diana.

  5. Raamatud

    Index Scriptorium Estoniae

    2006-01-01

    2006. a. Tallinnas TEA Kirjastuselt ilmunud Ira Diana Mazzoni raamatust "Aiad ja pargid : aiakunst antiigist tänapäevani" ja kirjastuselt Tänapäev ilmunud Mairo Rääski koostatud raamatust "Eesti sillad"

  6. Popmuusika / Margus Haav

    Index Scriptorium Estoniae

    Haav, Margus, 1969-

    2006-01-01

    Uutest heliplaatidest Agent M "Šokolaad EP", Diana Krall "From This Moment On", julio Iglesias "Romantic Classic", My Chemical Romance "The Black Parade", The Glove "Blue Sunshine", Level 42 "Retrogide", Stereotyp "Keepin'Me"

  7. Eesti Ajaloomuuseumi väliekspositsioon "Klooga laager ja holokaust" = Outdoor exhibition of the Estonian History Museum "Klooga camp and the holocaust"

    Index Scriptorium Estoniae

    2015-01-01

    Eesti Ajaloomuuseumi väliekspositsioon "Klooga laager ja holokaust" Kloogal, valminud 2013. Arhitektuuri sihtkapitali maastikuarhitektuuripreemia 2013. Arhitektuurne idee ja projekteerimine Mari Rass, Diana Taalfeld ja EA Reng. Kuraator Olev Liivik, konsultandid Ruth Bettina Birn, Tõnis Liibek, Meelis Maripuu

  8. Sistemas para a Sustentabilidade

    Directory of Open Access Journals (Sweden)

    Cristiane Gomes Barreto

    2014-12-01

    Full Text Available Obra resenhada: Donella Meadows. Thinking in systems: a primer. Edited by Diana Wright. White River Junction, Vermont: Chelsea Green Publishing Company, 2008. 185 p. eBook Inclui figuras e bibliografia. ISBN: 978-160358148-6.

  9. Võidupüha ja jaanipidu Melbourne'is / Raivo Rähni ; foto: Raivo Rähni

    Index Scriptorium Estoniae

    Rähni, Raivo, 1925-

    2009-01-01

    Melbourne'i Eesti Ühing "Kodu" poolt korraldatud peost Eesti Majas, kus sõna võtsid Bruno Metsar ja Diana Ritchie, esinesid Hilja Toom, Ambrose Ritchie, Mart ja Max Saarelaht, MEÜ "Kodu" Naiskoor, Angela Kerig jpt.

  10. Melbourne Eesti Ühing Kodu aasta peakoosolek / Sirje Jõgi

    Index Scriptorium Estoniae

    Jõgi, Sirje

    2007-01-01

    18. märtsil, ühingus on 209 liiget ja viis auliiget. Esitati aruanded, valiti uus 9 liikmeline juhatus: Bruno Metsar, Glory Toom, Milvi Vaikma, Sirje Jõgi, Rolf Luik, Imbi Knappstein, Rein Valling, Diana Ritchie ja Siiri Taveter

  11. Tartu Keskkonnahariduse Keskuse Loodusmaja = Nature School of Tartu Environmental Education Centre

    Index Scriptorium Estoniae

    2015-01-01

    Tartu Keskkonnahariduse Keskuse Loodusmaja Lille tänav 10, valminud 2013. Arhitektuurivõistlus 2010. Arhitektid Martin Kinks, Risto Parve, Kai Süda, Margit Valma (Karisma Arhitktid), Diana Taalfeld (NU Arhitektuur). Sisearhitekt Tõnis Kalve

  12. Plaadid / Brigitta Davidjants

    Index Scriptorium Estoniae

    Davidjants, Brigitta, 1983-

    2006-01-01

    Uutest heliplaatidest Sting "Songs From The Labyrinth", Jamelia "Walk With Me", Diana Krall "From This Moment On", Evanescene "The Open Door", Ursula "Armastan end aeglaselt", t.A.T.u. "The Best", Sandi Thom "Smile..."

  13. Research Article Special Issue

    African Journals Online (AJOL)

    pc

    2017-11-24

    Nov 24, 2017 ... grammatical phenomena of computer discourse in terms of the theory of ... Computers and computer technology have become a part of human life. ..... [19] Fried, Booth Diana L. Project Work (in Resource Books for Teachers) ...

  14. ¿Cómo se concibe la aventura?

    Directory of Open Access Journals (Sweden)

    Alicia Fajardo M.

    1989-01-01

    Full Text Available La tortuga desdentada. Alfonso Lobo Amaya. Edilux, Medellín, 1988, 16 págs. (Ilustraciones de Pilar Pabón Z .. El maravilloso viaje de Rosendo Bucurú. Celso Román. Carlos Valencia Editores, Bogotá, 96 págs. (Ilustraciones de Diana Castellanos. Una a ventura en el papel. Roberto Rubiano Vargas. Carlos Valencia. Editores, Bogotá, 1988, 104 págs. (Ilustraciones de Diana Castellanos

  15. Breaking the Ice: Potential U.S.-Russian Maritime Conflict in the Arctic

    Science.gov (United States)

    2012-12-01

    Tax and Investment Center Bulletin edited by Diana Nepolitano, “Ministry of Finance of the Russian Federation Expert Meeting on Oil and Gas Taxation ...msg_i/140//p1112021_russian_budget__oil_v3.pdf?941. Also, the International Tax and Investment Center Bulletin edited by Diana Nepolitano, “Ministry...of Finance of the Russian Federation Expert Meeting on Oil and Gas Taxation ,” ITIC Bulletin Special Edition, July 2011, http://www.iea.org/work/2011

  16. Field Research in Political Science Practices and Principles

    DEFF Research Database (Denmark)

    Gravier, Magali

    2017-01-01

    Book review of: Kapiszewski (Diana), Maclean (Lauren M.), Read (Benjamin L.) ­ Field Research in Political Science. Practices and Principles. ­ Cambridge, Cambridge University Press, 2015 (Strategies for Social Inquiry). XIV + 456 p. Figures. Annexe. Bibliogr. Index.......Book review of: Kapiszewski (Diana), Maclean (Lauren M.), Read (Benjamin L.) ­ Field Research in Political Science. Practices and Principles. ­ Cambridge, Cambridge University Press, 2015 (Strategies for Social Inquiry). XIV + 456 p. Figures. Annexe. Bibliogr. Index....

  17. 25 years of service at CERN

    CERN Multimedia

    2014-01-01

    The 28 staff members having achieved 25 years of service at CERN in 2014 were invited by the Director-General to a reception in their honour on 25 November 2014.       Alberto AIMAR IT   Patrick BERLINGHI  GS   Horst  BREUKER  PH   Paolo  CHIGGIATO  TE   Jorgen  CHRISTIANSEN PH   Ivan  DELOOSE  IT   Martine   DESNYDER-IVESDAL  PH   Laurent  DUCIMETIERE   TE   Bruno  DUPUY  BE   Alan James  FINDLAY  BE   Jean-Jacques   GRAS BE   Michael  HAUSCHILD PH   Erk  JENSEN  BE   Michael  LAMONT&...

  18. Sofia Ionescu, the first woman neurosurgeon in the world.

    Science.gov (United States)

    Ciurea, Alexandru-Vlad; Moisa, Horatiu Alexandru; Mohan, Dumitru

    2013-11-01

    The authors present the activity of Mrs. Sofia Ionescu, the one female surgeon who was nominated as the first woman neurosurgeon in the world. Sofia Ionescu worked in the field of neurosurgery for 47 years, performing all the known neurosurgical procedures of the time. She made herself known through her incredible surgical skill and her enormous work power. Due to her incredible modesty and workload, she never participated at international congresses or manifestations. The nomination as first woman neurosurgery took place in Marrakech, Morocco, during the 2005 WFNS Congress. Although some claim that Diana Beck was the first woman neurosurgeon in the world, our theory suggests otherwise. The first documented surgical intervention performed by Diana Beck dates to 1952. Sofia Ionescu operated for the first time on a human brain as early as 1944. Furthermore, Diana Beck's actions surfaced in the year 1947, long after the war had ended and Sofia Ionescu had become a neurosurgeon. Copyright © 2013. Published by Elsevier Inc.

  19. "The black and white of it": Barbara Grier editing and publishing women of color.

    Science.gov (United States)

    Enszer, Julie R

    2014-01-01

    In the 1970s and 1980s, lesbian-feminist writing and publishing expressed new theoretical insights about race and envisioned new, intersectional identities. Using texts published and edited by Grier in The Ladder and subsequent Ladder anthologies published by Diana Press, archival documents from Diana Press, and the Grier-Naiad Press papers, this article explores Grier's editorial practices and compares Grier's work to other lesbian-feminist editors and publishers to illuminate different generational understandings of racial-ethnic and class formations within lesbianism and feminism and highlight some of the strategies that White publishers like Grier utilized to realize a vision of multicultural publishing.

  20. An Atlas of Type I MADS Box Gene Expression during Female Gametophyte and Seed Development in Arabidopsis[W].

    NARCIS (Netherlands)

    Bemer, M.; Heijmans, K.; Airoldi, C.A.; Davies, B.; Angenent, G.C.

    2010-01-01

    Members of the plant type I MADS domain subfamily have been reported to be involved in reproductive development in Arabidopsis (Arabidopsis thaliana). However, from the 61 type I genes in the Arabidopsis genome, only PHERES1, AGAMOUS-LIKE80 (AGL80), DIANA, AGL62, and AGL23 have been functionally

  1. Peeter I residentsid / Jüri Kuuskemaa

    Index Scriptorium Estoniae

    Kuuskemaa, Jüri, 1942-

    2005-01-01

    Peeter I linnaresidents Tolli t. 4 Tallinnas, maja (1662, 1714) ning lossi- ja pargiansambel (1718, arhitekt Niccolo Michetti, 1923. aasta sügisest ehitusel vastutav Mihhail Zemtsov, stukk Antonio Quadri, Salomon Zeltrecht, Matthias Seidtinger, Heinrich von Bergen, laemaal "Diana ja Aktaion" - Ernst Wilhelm Londicer noorem?, laemaaling merepoolses tiibhoones - Johann Heinrich Fick) Kadriorus. Bibliograafia lk. 454

  2. Navy and Coast Guard Shipbuilding: Navy Should Reconsider Approach to Warranties for Correcting Construction Defects

    Science.gov (United States)

    2016-03-01

    As noted in the report, we found that different stakeholders within the Navy used the guaranty to accomplish differing and, at times, contradictory...staff members made key contributions to this report: Diana Moldafsky, Assistant Director; Laurier Fish; Joseph Franzwa; Ronald Freeman ; Laura

  3. Litsid ja kunstnikud näitusesaalis / Teet Veispak

    Index Scriptorium Estoniae

    Veispak, Teet, 1955-

    2007-01-01

    Näitusest "Kehaturg" Tallinna Kunstihoones, kuraator Reet Varblane. Liina Siibi videost "Vastumeelne keha", soome kunstniku Teemu Mäki väljapanekust "Prostitutsioonist", malaisia fotograafi Diana Lui fotoseeriast, rootsi-eesti fotograafi Bie Erenurme väljapanekust "Mu ema on lits", Sandra Jõgeva näitusel eksponeeritud šokolaadiümbristest

  4. Pop / Mart Juur

    Index Scriptorium Estoniae

    Juur, Mart, 1964-

    2002-01-01

    Heliplaatidest Kiss "The Very Best of Kiss". Andrew Lloyd Webber presents: "A R Rahman's Bombay Dreams". Naughty By Nature "Ilkons". Erinevad esinejad "One word one sound". Diana King "Respect". Caater "Club Space (Estonian Edition)". J.M.K.E. "Ainult planeet". Collage "Parimad lood 1970-1976". Cinematic Orchestra "Every Day". Catatonia "Greatest Hits". Boards of Canada "Geogaddi"

  5. Selgusid Betti Alveri preemia nominendid

    Index Scriptorium Estoniae

    2005-01-01

    Betti Alveri kirjandusauhinna nominendid: Sass Henno "Mina olin siin", Andrei Hvostovi "Lombakas Achilleus", Mart Kanguri, Jaak Ranna ja Ivar Ravi "Jaak Rand ja teisi jutte", Diana Leesalu "2 grammi hämaruseni", Jaan Pehki "Sisukord", Linnar Priimäe "Kelle tee on varjul", Leo de Sixtuse "Skarabeuse tsivilisatsioon". Vt. ka Eesti Päevaleht, 16. nov., lk. 15

  6. Betti Alveri sünniaastapäeval kuulutatakse välja järjekordne Alveri kirjandusauhinna saaja...

    Index Scriptorium Estoniae

    2005-01-01

    Kirjandusauhinna nominendid: Sass Henno. Mina olin siin ; Andrei Hvostov. Lombakas Achilleus ; Mart Kangur, Jaak Rand ja Ivar Ravi. Jaak Rand ja teisi jutte ; Diana Leesalu. 2 grammi hämaruseni ; Jaan Pehk. Sisukord ; Linnar Priimägi. Kelle tee on varjul ; Leo de Sixtus. Skarabeuse tsivilisatsioon

  7. Browse Title Index

    African Journals Online (AJOL)

    Items 701 - 736 of 736 ... Vol 14, No 4 (2017), Utilitarian theatre forms and their relatedness: the imperative of conceptual clarifications, Abstract. Edward Ugbada Adie. Vol 14, No 2 (2017), Utilitarianism as a Veritable Vehicle for the Promotion of a Just Society, Abstract. Ephraim A. Ikegbu, Francis I. Diana-Abasi. Vol 8, No 3 ...

  8. 76 FR 51943 - Proposed Information Collection; Comment Request; International Dolphin Conservation Program

    Science.gov (United States)

    2011-08-19

    ... vessel characteristics and operations in the ETP, the origin of tuna and tuna products, and certain other... origin of tuna (if requested by the NOAA Administrator); 10 hours for an experimental fishing operation... October 18, 2011. ADDRESSES: Direct all written comments to Diana Hynek, Departmental Paperwork Clearance...

  9. Ghana Journal of Development Studies - Vol 14, No 1 (2017)

    African Journals Online (AJOL)

    Ghanaian Consumers' Attitudes toward Cisgenic Rice: Are all Genetically Modified Rice the Same? EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Francis Tsiboe, Lawton L. Nalley, Bruce L. Dixon, Diana Danforth, Anne-Cécile Delwaide, Rodolfo M. Nayga, 1-18.

  10. Analysis of Parental Involvement and Self-Esteem on Secondary School Students in Kieni West Sub-County, Nyeri County, Kenya

    Science.gov (United States)

    Wairimu, Mburu Josephine; Macharia, Susan M.; Muiru, Ann

    2016-01-01

    This study investigated the relationship between parental involvement and the self-esteem among adolescents in secondary school students in Kieni West District in Nyeri County. It was guided by Self Determination Theory (SDT) by James William and Baumrind Theory of Parenting Styles by Diana Blumberg Baumrind. Some of the gaps identified in the…

  11. Anneteparaad III / Karin Paulus

    Index Scriptorium Estoniae

    Paulus, Karin, 1975-

    2008-01-01

    Tutvustatakse Tartu Kõrgema Kunstikooli diplomandide lõputöid: 1. Diana Hints "Ba-Rokk", 2. Maire Rebina "Alleshoitud naeratused", 3. Liis Pihlik "Unistused ehk hingele pai", 4. Ille Agu "Pitsiring - pruudipesu kollektsioon", 5. Ingwald Koser "Chaise Longue", 6. Kaisa Paluoja installatsioon "/....../", 7. Kaidi Ploomipuu arvutiga juhitavatel telgedel kootud sisustuskangas

  12. Legal framework of the Radiation Protection in Guatemala

    International Nuclear Information System (INIS)

    Freire, Diana

    2002-01-01

    This presentation prepared by the Deputy Director of Energy Mrs. Diana Freire de Nave overviews the following issues: objectives and functions of the national authority on the following activities: controlling, licensing and inspections. Also describes the legal process to authorize installations, operators, equipment and the legal frame on radiation safety in Guatemala

  13. Making Matter Making Us: Thinking with Grosz to Find Freedom in New Feminist Materialisms

    Science.gov (United States)

    Jackson, Alecia Youngblood

    2013-01-01

    In this paper, I offer a very close reading of Grosz [2010. "Feminism, Materialism, and Freedom." In "New Materialisms: Ontology, Agency, and Politics," edited by Diana Coole and Samantha Frost, 139-157. Durham, NC: Duke University Press] thinking with Bergson in order to re-conceptualise freedom, matter, and the subject in new…

  14. Spring Research Festival and NICBR Collaboration Winners Announced | Poster

    Science.gov (United States)

    By Carolynne Keenan, Contributing Writer, and Ashley DeVine, Staff Writer The winners of the 2014 Spring Research Festival (SRF), held May 7 and 8, were recognized on July 2, and included 20 NCI at Frederick researchers: Matthew Anderson, Victor Ayala, Matt Bess, Cristina Bergamaschi, Charlotte Choi, Rami Doueiri, Laura Guasch Pamies, Diana Haines, Saadia Iftikhar, Maria

  15. Automated calculations for massive fermion production with ai-bar Talc

    International Nuclear Information System (INIS)

    Lorca, A.; Riemann, T.

    2004-01-01

    The package ai-bar Talc has been developed for the automated calculation of radiative corrections to two-fermion production at e + e - colliders. The package uses Diana, Qgraf, Form, Fortran, FF, LoopTools, and further unix/linux tools. Numerical results are presented for e + e - -> e + e - , μ + μ - , bs-bar , tc-bar

  16. Working with Staff Using Baumrind's Parenting Styles Framework

    Science.gov (United States)

    Veldhuis, Hollace Anne

    2012-01-01

    The author's presentation at the staff meeting centered on Diana Baumrind's parenting styles framework (Baumrind, 1967). Baumrind believed that there were four requirements for effective guidance: nurturing, communication, maturity demands, and control. She rated parents on these four dimensions and identified the pattern of parenting that…

  17. Rethinking "Harmonious Parenting" Using a Three-Factor Discipline Model

    Science.gov (United States)

    Greenspan, Stephen

    2006-01-01

    Diana Baumrind's typology of parenting is based on a two-factor model of "control" and "warmth". Her recommended discipline style, labeled "authoritative parenting", was constructed by taking high scores on these two factors. A problem with authoritative parenting is that it does not allow for flexible and differentiated responses to discipline…

  18. Parents as Leaders: The Role of Control and Discipline.

    Science.gov (United States)

    Yahraes, Herbert

    This paper reviews Diana Baumrind's studies of the effect of various types of parental control on children's behavior and concludes that a child is more likely to develop a sense of competence, responsibility, and independence if he or she is given firm and reasonable guidelines. A brief survey of Baumrind's first two studies of preschool children…

  19. Handbook of Parenting. Volume 5: Practical Issues in Parenting. Second Edition.

    Science.gov (United States)

    Bornstein, Marc H., Ed.

    Concerned with practical aspects of meeting children's needs, this volume, the fifth of five on parenting, describes the nuts and bolts of parenting as well as the promotion of positive parenting practices. The volume consists of the following 19 chapters: (1) "The Ethics of Parenting" (Diana Baumrind and Ross A. Thompson; (2) "Parenting and…

  20. JiaZhang Dui ErTong FaZhan TongBan GuanXi De ZuoYong (The Role of Parents in the Development of Peer Group Competence). ERIC Digest.

    Science.gov (United States)

    Moore, Shirley G.

    Among studies that have examined the relationship between parenting styles and children's development of social skills, the research of Diana Baumrind is noteworthy. In several studies, she has identified authoritarian, permissive, and authoritative parenting styles, which differ on the dimensions of nurturance and parental control. Authoritarian…

  1. The Role of Parents in the Development of Peer Group Competence. ERIC Digest.

    Science.gov (United States)

    Moore, Shirley G.

    Among studies that have examined the relationship between parenting styles and children's development of social skills, the research of Diana Baumrind is noteworthy. In several studies, she has identified authoritarian, permissive, and authoritative parenting styles, which differ on the dimensions of nurturance and parental control. Authoritarian…

  2. Sex Differences in the Development of Moral Reasoning: A Rejoinder to Baumrind.

    Science.gov (United States)

    Walker, Lawrence J.

    1986-01-01

    Addresses the criticisms of Diana Baumrind's review of his research on sex differences in moral reasoning development. Discusses issues such as the nature of moral development, the focus on adulthood, the choice of statistics, the effect of differing sample sizes and scoring systems, and the role of sexual experiences in explaining variability in…

  3. Mõnda mõnusat teismelise tüdruku lugemislauale / Aidi Vallik

    Index Scriptorium Estoniae

    Vallik, Aidi, 1971-

    2007-01-01

    Kuuest tüdrukuteraamatust: Diana Leesalu "Kaks grammi hämaruseni", Helen Crossi "Minu armastuse suvi", Ann Brashare'i "Rändavate Pükste õeskond", Eva Ibbotsoni "Reis Merejõele", Sue Limbi "Tüdruk, 15, sarmikas, kuid sõge", Louise Rennisoni "Poisid, stringid ja ogar kass"

  4. Kuidas staarnäitlejatest abielupaar vangi pandi / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2010-01-01

    Eesti Draamateatris loeti näidendit Mari Möldre ja Ruut Tarmo vangistamisest Stalini ajal. Dokumendid leidis arhiividest ajaloolane Mart Laar, näidendi "Mari ja Ruut" autorid on lavakunstikooli tudengid Diana Leesalu ja Paavo Piik. Möldre rolli luges Anu Lamp, Tarmo rolli Elmo Nüganen, lugemise lavastas Merle Karusoo

  5. Perceived Advantages and Disadvantages of Being a Female Graduate Student in the US and the UK

    Science.gov (United States)

    Mehta, Clare Marie; Keener, Emily; Shrier, Lydia

    2013-01-01

    We build on Diana Leonard's work on gender and graduate education by qualitatively investigating the perceived advantages and disadvantages of being a female graduate student in the USA and the UK. We interviewed six female students (ages 22-30) pursuing master's degrees in psychology or social sciences in the USA and the UK. Students from both…

  6. Blastomycosis Mortality Rates, United States, 1990–2010

    Centers for Disease Control (CDC) Podcasts

    2015-01-05

    Diana Khuu discusses Blastomycosis Mortality Rates, United States, 1990–2010.  Created: 1/5/2015 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 1/7/2015.

  7. Land & Development in Latin America: Issues and Openings for ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Land & Development in Latin America: Issues and Openings for Policy Research. Book cover Land & Development in Latin America: Issues and Openings for Policy Research. Auteur(s) : Stephen Baranyi, Carmen Diana Deere, and Manuel Morales. Maison(s) d'édition : North-South Institute, IDRC. 1 janvier 2004. ISBN :.

  8. Mini-Portfolio on Math and Science.

    Science.gov (United States)

    Teaching PreK-8, 1996

    1996-01-01

    Presents six articles dealing with math and science education: "Sneaker Geometry" (Jack George), "Fairs with a Flair" (Diane McCarty), "Generating Excitement with Math Projects" (Jeffrey Kostecky and Louis Roe), "Playing with Numbers" (Diana Smith), "When Student Teachers Want to Do Hands-On Science" (Betsy Feldkamp-Price), and "Science ala Carte"…

  9. Women and Technical Professions. Leonardo da Vinci Series: Good Practices.

    Science.gov (United States)

    Commission of the European Communities, Brussels (Belgium). Directorate-General for Education and Culture.

    This document profiles programs for women in technical professions that are offered through the European Commission's Leonardo da Vinci program. The following programs are profiled: (1) Artemis and Diana (vocational guidance programs to help direct girls toward technology-related careers); (2) CEEWIT (an Internet-based information and…

  10. Valik konkursi "Noored poeedid 2009" alapealkirjaga "See on rõõm elust endast" tunnustust pälvinud töödest : [luuletused

    Index Scriptorium Estoniae

    2009-01-01

    Vanem vanuseaste 1. koht Triin Sepp, 2. koht Triinu Ansper, 3.-4. koht Kairi Sepp ja Heli Armus. Keskmine vanuseaste 1. koht Annaliis Lehto, 2. koht Liina Salonen, 3. koht Gerda-Liis Palmiste. Noorem vanuseaste 1. koht Reet Rüütel, 2. koht Diana Kasesalu, 3. koht Eliis Mets

  11. Screening Mammography: Science, Policy and Politics–The Good, the Bad and the Ugly

    Science.gov (United States)

    Diana Petitti, MD, MPH, FACPM, an epidemiologic expert on women's health and evidence based medicine, with posts as vice chair and spokesperson for the U.S. Preventive Service Task Force, presented "Screening Mammography: Science, Policy and Politics–The Good, the Bad and the Ugly." 

  12. 76 FR 3090 - Proposed Information Collection; Comment Request; Alaska Region; Bering Sea and Aleutian Islands...

    Science.gov (United States)

    2011-01-19

    ... submitted on or before March 21, 2011. ADDRESSES: Direct all written comments to Diana Hynek, Departmental... fisheries. Program components include quota share allocation, processor quota share allocation, individual... Binding Arbitration process, and fee collection. II. Method of Collection Responses are mailed, except the...

  13. 76 FR 65180 - Proposed Information Collection; Comment Request; Application to Shuck Surf Clams/Ocean Quahogs...

    Science.gov (United States)

    2011-10-20

    .... Method of Collection Requests from allocation holders to transfer quota use paper applications or an... submitted on or before December 19, 2011. ADDRESSES: Direct all written comments to Diana Hynek... transferable quota (ITQ) allocation holders in order to process and track requests from the allocation holders...

  14. 75 FR 5760 - Proposed Information Collection; Comment Request; Western Alaska Community Development Quota Program

    Science.gov (United States)

    2010-02-04

    ... before April 5, 2010. ADDRESSES: Direct all written comments to Diana Hynek, Departmental Paperwork... and diversified local economies in western Alaska. CDQ and prohibited species quota (PSQ) allocations... collection. II. Method of Collection Respondents have a choice of either electronic or paper forms. Methods...

  15. 75 FR 12173 - Proposed Information Collection; Comment Request; Defense Priorities and Allocations System

    Science.gov (United States)

    2010-03-15

    ... Allocations System regulation (15 CFR part 700) must retain the records for at least 3 years. II. Method of... Request; Defense Priorities and Allocations System AGENCY: Bureau of Industry and Security, Commerce...: Direct all written comments to Diana Hynek, Departmental Paperwork Clearance Officer, Department of...

  16. The Rules of the Game: Women and the Leaderist Turn in Higher Education

    Science.gov (United States)

    Morley, Louise

    2013-01-01

    This paper engages with Diana Leonard's writing on how gender is constituted in the academy. It offers an international review of feminist knowledge on how gender and power interact with leadership in higher education. It interrogates the "leaderist turn" or how leadership has developed into a popular descriptor and a dominant social and…

  17. Tähtis on hoida ühtset joont / Agne Adamson

    Index Scriptorium Estoniae

    Adamson, Agne

    2011-01-01

    Eesti Perearstide Seltsi 2008. a. valitud juhatuse tööst kolme aasta vältel ning tulevikuvisioonidest. Vestlusringis osalesid Ruth Kalda, Diana Ingerainen, Madis Tiik, Eret Jaanson, Anneli Talvik, Katrin Martinson ja Külvi Peterson. Kommentaarid EPS-i liikmetelt

  18. Introduction to "Multicultural Voices: Peer Tutoring and Critical Reflection in the Writing Center"

    Science.gov (United States)

    Grimm, Nancy Maloney

    2010-01-01

    In 1991 when Diana George, Ed Lotto, and the author were publishing their first issue as "WCJ" editors, this multivoiced essay struck her as a prime example of their editorial belief that writing centers could be "agents of change in the academy." As Gail Okawa and Tom Fox observe, "Most universities are inhospitable to more democratic definitions…

  19. Marr: Magpie or Marsh Harrier? The Quest for the Common Characteristics of the Genus "Historian" with 16- to 19-Year-Olds

    Science.gov (United States)

    Laffin, Diana

    2012-01-01

    Diana Laffin writes about historical language and explores how understanding different historians' use of language can help sixth form students refine and deepen both their understanding of the discipline of history and their abilities to practise the discipline in their own writing. What does close study of the textual habits and practices of…

  20. Möllavad (nais)hormoonid / Margus Kiis

    Index Scriptorium Estoniae

    Kiis, Margus

    2004-01-01

    Fideelia (Signe-Fideelia Roots) maalinäitus "Kurjaloomakobrikas" (5.-16. IV), Anna Kainulaineni maalinäitus "Keha, tants ja mäng" (6.-16. IV), Piret Räni fotonäitus "Punk.Fem" ja Die (Diana Ostrat) fotoinstallatsioon "Müsteerium 35 aktis" (kuni 2. V) Y-galeriis

  1. Concursos

    Directory of Open Access Journals (Sweden)

    Boletín Cultural y Bibliográfico Banco de la República

    1986-10-01

    Full Text Available Se presenta la información y bases de los siguientes premios y concursos: VII Concurso de poesía Universidad de Antioquia 1986; Premio novela: Novedades y Diana; Premio Internacional Gabriela Mistral 1987; Becas en el exterior para artistas Un músico, un cantante, un artista plástico.

  2. An Analysis of the Distinction between Deep and Shallow Expert Systems

    Science.gov (United States)

    1989-08-01

    Standards Yorktown Heighta, NY 10500 Gaithersburg, MD 20896 Dr. Saul Amarel Dept. of Computer Science Dr. Harold Bamford CDR Robert Carter Rutgero...Michigan Marina Del Ray, CA 00232 320 Packard Read Ann Arbor, MI 48103 Mr. Colin Sheppard Dr. Diana We.r-e AXC2 Block I Mr. Prasad Tadepalli Department of

  3. New Baltic Drama 2011 võidunäidend jõuab Linnateatri lavale

    Index Scriptorium Estoniae

    2011-01-01

    Rahvusvahelisest näidendivõistlusest, mille võidunäidendid on Martin Alguse "Kontakt" (Eesti), Pipsa Lonkka "These Little Town Blues Are Melting Away" (Soome), Semjon Kirovi "Ilja päev" (Venemaa), Johanna Emanuelssoni "Vaata, ma kukun" ("Älfsborgi sild", Rootsi). Viimast hakkab Tallinna Linnateatris lavastama Diana Leesalu

  4. Kapo ei mõista naiste nalja / Mihkel Kärmas

    Index Scriptorium Estoniae

    Kärmas, Mihkel, 1974-

    2003-01-01

    Kaitsepolitsei poolt pistise väljapressimises süüdistatav justiitsministeeriumi referent väidab, et tegi sõbrannaga telefonis altkäemaksust rääkides nalja. Kairi Kõrmi ja Diana Eelmaa telefonikõne salvestusest

  5. 76 FR 79152 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-12-21

    ... DEPARTMENT OF COMMERCE Submission for OMB Review; Comment Request The Department of Commerce will... occasion. Respondent's Obligation: Required to obtain or retain benefits. OMB Desk Officer: OIRA_Submission... writing Diana Hynek, Departmental Paperwork Clearance Officer, (202) 482-0266, Department of Commerce...

  6. Kunsti kuumtöötlus Läti aladel / Mari Sobolev

    Index Scriptorium Estoniae

    Sobolev, Mari, 1968-

    2004-01-01

    Pedvale vabaõhumuuseumis toimunud rahvusvahelisest workshop'ist teemal "Kompost", mille tulemusi presenteeriti 6. VIII 2004. Ignas Kazakeviciuse, Jurate Rakeviciute, Diana Dimzha-Dime, Ule Björn Gundermanni, Remo Randveri, Maris Grosbahsi, Andrus Joonase töödest

  7. 75 FR 63438 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2010-10-15

    ... DEPARTMENT OF COMMERCE Submission for OMB Review; Comment Request The Department of Commerce will... persons to participate in the development of such plans, and (b) which take into account the social and... writing Diana Hynek, Departmental Paperwork Clearance Officer, (202) 482-0266, Department of Commerce...

  8. Brava gente brasileira e o “Brasil 500”: o espetáculo do descobrimento

    Directory of Open Access Journals (Sweden)

    Kátia da Costa Bezerra

    2011-01-01

    Full Text Available Based on studies of Diana Taylor, Anthony Pagden and Jean Starobinski, this essay examines how the film Brava gente brasileira, dramatizes some of the conflicts present in the reenactment of the discovery during the celebrations of the “Brazil 500.” The purpose is to reflect on some of intertexts involved in the process of building a sense of Brazilianness.

  9. El Papel de los Padres en el Desarrollo de la Competencia Social (The Role of Parents in the Development of Peer Group Competence). ERIC Digest.

    Science.gov (United States)

    Moore, Shirley G.

    Among studies that have examined the relationship between parenting styles and children's development of social skills, the research of Diana Baumrind is noteworthy. In several studies, she has identified authoritarian, permissive, and authoritative parenting styles, which differ on the dimensions of nurturance and parental control. Authoritarian…

  10. The Puerto Ricans: Their History, Culture, and Society.

    Science.gov (United States)

    Lopez, Adalberto, Ed.

    Articles in this book cover Puerto Rican history from the Spanish colonization to the present day experience of Puerto Ricans in the United States. Political, social, economic, cultural, and historical issues are addresed by the following authors: Edna Acosta-Belen, Frank Bonilla, Juan Manuel Carrion, Diana Christopulos, Sandra Messinger Cypess,…

  11. Ciudades Seguras e Inclusivas Investigación para reducir la ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    PANELISTAS. Dra. Nausheen H. Anwar. Institute of Business Administration,. Pakistán. La encrucijada de vulnerabilidad, género y violencia en el Pakistán urbano. Alice Taylor. Instituto Promundo, Brazil. Comprensión de las identidades masculinas no violentas para ciudades seguras e inclusivas. Diana Sánchez ...

  12. Eesti mood versus Vene mood / Anne Metsis

    Index Scriptorium Estoniae

    Metsis, Anne, 1958-

    2008-01-01

    Kauplusest "Iida" Tallinna vanalinnas Suur-Karja tn. 2. Sisekujundus Taso Mäharilt. Poes müüakse Kristina Viirpalu disainitud rõivaid, Eva-Liisa Kriisa kujundatud mööblit. Rjazanist pärit moekunstnikust Diana Denissovast

  13. 78 FR 26867 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate

    Science.gov (United States)

    2013-05-08

    ... residents, as defined in section 877(e)(2), are treated as if they were citizens of the United States who... GERRING BANG HEESEUNG BARRAZA SANTIAGO E BARTEL-MOUFANG DIANA BATTIG RAINER KARL BAUMANN MARTIN PETER... SUSANNE BARBARA HATHAWAY JANET K HAUPTLI DIANE MARIE HAY KATHERINE MARIE HEBRON VERA HEIM JULIA HEIM MARC...

  14. Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (85th, Miami, Florida, August 5-8, 2002). Media Ethics Division.

    Science.gov (United States)

    2002

    The Media Ethics division of the proceedings contains the following 6 papers: "A Masochist's Teapot: Where to Put the Handle in Media Ethics" (Thomas W. Hickey); "Stalker-razzi and Sump-pump Hoses: The Role of the Media in the Death of Princess Diana" (Elizabeth Blanks Hindman); "The Promise and Peril of Anecdotes in News…

  15. Citizenship Education Research in Varied Contexts: Reflections and Future Possibilities. A Review Essay

    Science.gov (United States)

    Tudball, Libby

    2015-01-01

    Three books are the subject of this review essay: (1) Avril Keating's (2014) publication, "Education for Citizenship in Europe: European Policies, National Adaptations and Young People's Attitudes"; (2) "The Political Classroom: Evidence and Ethics in Democratic Education", Diana Hess and Paula McAvoy (2015); and (3) "We…

  16. Vene kirjandusest balti aktsendiga

    Index Scriptorium Estoniae

    2006-01-01

    24. nov. esitletakse Tallinnas Kirjanike majas almanahhi "Tuulelohe : vene kirjandus balti aktsendiga" ("Vozdushnõi zmei. Russkaja literatura s baltiiskim aktsentom"). Esinevad P. I. Filimonov, Deniss Kuzmin, Diana Efendijeva, Larissa Joonas, Dmitri Krasnov, Irina Meljakova, Jashka Gromova. Õhtut juhib almanahhi toimetaja Igor Kotjuh

  17. Kümme teatristarti alustas suureks kasvamisega / Tiiu Laks

    Index Scriptorium Estoniae

    Laks, Tiiu,1984-

    2010-01-01

    Tallinna Linnateater annab kümnele algajale võimaluse lavastada professionaalses teatris. 6. oktoobril esietendunud monotükist "Suur mees juba", millega jõudis lavale kolm professionaalset debüüti korraga - Kaarel B. Väljamäe esimene teatritekst, Diana Leesalu esimene lavastus ning Priit Piusi esimene suur roll

  18. Republic of Noise: The Loss of Solitude in Schools and Culture

    Science.gov (United States)

    Senechal, Diana

    2011-01-01

    In "Republic of Noise," Diana Senechal confronts a culture that has come to depend on instant updates and communication at the expense of solitude. Where once it was common wisdom that the chatter of the present, about the present, could not always grasp the present, today we treat "real time" as though it were the only real time. Schools…

  19. Una vaca y el Popul Vuh

    Directory of Open Access Journals (Sweden)

    Antonio Silvera Arenas

    1997-09-01

    Full Text Available La vaca chiraca está enamorada. Lucy Amado, Diana Rodríguez (ilus.. Editora Medio Ambiente, Santafé de Bogotá, 1996, 33 págs. Los hijos de los astros. Jaime Restrepo Ch., ilustraciones de Silvia M. Duque H. Jaime Restrepo Ch., Silvia M. Duque H., editores, Manizales, 1996, 51 págs.

  20. Kunstiakadeemia disainikonverents

    Index Scriptorium Estoniae

    2003-01-01

    8.-10. V Rotermanni soolalaos ja Eesti Kunstiakadeemias rahvusvaheline disainikonverents "VALID : VALue in Design", mille korraldab EKA koostöös rahvusvahelise kunsti-, disaini- ja arhitektuurikõrgkoolide assotsiatsiooniga CUMULUS. Peaesinejad Diana Crane, Natasha Vita-More (USA), Carlo Vezzoli (Itaalia)

  1. Concursos

    Directory of Open Access Journals (Sweden)

    Boletín Cultural y Bibliográfico Banco de la República

    1990-05-01

    Full Text Available Se presenta la información y bases de los siguientes premios y concursos: Bienal del humor y la sátira; Concurso Enka de Literatura Infantil; Concurso literario editorial Diana y novedades; Premio Eloy Valenzuela; Diseño de carátulas y comentarista de libros.

  2. Vaid klaas vett päevas / Kadri Kalda

    Index Scriptorium Estoniae

    Kalda, Kadri

    2013-01-01

    Rahvusvahelisest koostööprojektist Ghana St Raphaeli algkooli, Valga gümnaasiumi ja EBS-i gümnaasiumiga teemal „Vesi ja sanitaartingimused”. Abistas Põhja-Ghanas Kongo külas töötanud MTÜ Mondo vabatahtlik Diana Tamm

  3. Rokiklubis kuuleb punki, bluusi ja rock'n'roll'i / Anniki Leppik

    Index Scriptorium Estoniae

    Leppik, Anniki

    2008-01-01

    Üritusest "Anarchy In The EST 2008" 2. mail Pärnu rokiklubis aadressil Papiniidu 50), esinejateks bändid Flowers Of Romance, Dirty Diana, HuuliGäänz ja Gang Bang Cafe, 3 mail esinemas bändid Route 60 ja Pickups, 16. mail Sõpruse Puiestee

  4. Automation of Feynman diagram evaluations

    International Nuclear Information System (INIS)

    Tentyukov, M.N.

    1998-01-01

    A C-program DIANA (DIagram ANAlyser) for the automation of Feynman diagram evaluations is presented. It consists of two parts: the analyzer of diagrams and the interpreter of a special text manipulating language. This language can be used to create a source code for analytical or numerical evaluations and to keep the control of the process in general

  5. A Sacrificial Lam: A Divided School Board, a Beleaguered Superintendent, and an Urgent Need to Improve Student Achievement

    Science.gov (United States)

    Fossey, Richard

    2011-01-01

    This case describes the confrontational relationship between four trustees on the San Antonio School Board and the San Antonio School District's superintendent Diana Lam, a nationally recognized school reformer, who came to San Antonio in 1994. The case includes a dramatic board meeting where a closely divided board meets to buy out Lam's…

  6. 76 FR 47539 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-08-05

    ... of information under the provisions of the Paperwork Reduction Act (44 U.S.C. chapter 35). Agency: U... critical decision-making on a variety of issues including market trends, analysis, and segmentation. Each... proposal can be obtained by calling or writing Diana Hynek, [[Page 47540

  7. Uus Tartu Loodusmaja = The new Tartu Nature Building / Tiit Sild

    Index Scriptorium Estoniae

    Sild, Tiit, 1977-

    2010-01-01

    Tartu Loodusmaja avalikust arhitektuurivõistlusest, kvalifitseerimistingimustest, energiatõhususest ja žürii tööst. 1. preemia sai töö "Känd", autorid Diana Taalfeld, Kai Süda, Margit Valma, Martin Kinks (Urmas Lõokese AB / Karisma Arhitektid). Nimetatud 2. ja 3. koha saanud tööd, autorid

  8. Hay huellas en el cuerpo

    Directory of Open Access Journals (Sweden)

    Julia Bertone

    2011-12-01

    Full Text Available La presente reseña introduce y comenta el libro de los compiladores Victoria D`hers y Eduardo Galak “Estudios sociales sobre el cuerpo: prácticas, saberes, discursos en perspectiva”; el cual surge en el marco de las “VI Jornadas de Sociología de la UNLP” y consta de un prólogo realizado por Adrián Scribano y Lucas Aimar, y once artículos producidos por jóvenes investigadores en relación a los Cuerpos y las Emociones.Los autores proponen recorrer un mapeo y ensayar lecturas sobre las conexiones entre prácticas corporales, afecciones y emociones. La escritura y el modo de presentación del libro reflejan la textura de la temática y la complejidad del espacio de reflexión. Desde una sociología de los cuerpos y las emociones es posible hallar pistas que nos conduzcan a comprender el sentido que los actores dan a sus prácticas; identificar nodos conflictuales que emergen en esas comprensiones cotidianas; y dar cuenta de cómo la sociedad que se hace cuerpo, puede ser rastreada a partir del análisis de determinadas emociones sociales. Desde el título podemos reconocer que el libro deja huellas para comprender que el propio cuerpo es discusión del presente y del futuro inmediato.

  9. Application of PIXE to the study of Renaissance style enamelled gold jewelry

    Science.gov (United States)

    Weldon, M.; Carlson, J.; Reedy, S.; Swann, C. P.

    1996-04-01

    This study examines and compares three pieces of Renaissance style gold and enamelled jewelry owned by the Walters Art Gallery, Baltimore, MD, USA. These are a 16th century Hat Badge of Adam and Eve, a 19th century Fortitude Pendant and a Diana Pendant presumed to be of the 16th century (The Walters Art Gallery, Jewelry, Ancient to Modern (Viking, New York, 1979)), Ref. [1]. PIXE spectroscopy was applied to examine the elemental composition of the gold and of the enamels. Compositional differences, including the use of post-Renaissance colorants, were found between the enamels in separate regions of each of the three pieces. The modern colorant, chromium, was, in fact, found in all of the pieces and uranium was found in only the Diana Pendant. There are some differences in the gold purity of the three objects; there are significant differences in the solders used even within one object, the Fortitude Pendant.

  10. Personal Branding Through Fashion Blogging

    Directory of Open Access Journals (Sweden)

    Yuanita Safitri

    2017-01-01

    Full Text Available The objective of this research was to analyze personal branding development from personal brand identity, personal brand positioning, and personal brand assessment. The object of this research was Diana Rikasari's blog “Hot Chocolate and Mint”. She is one of prominent influence and fashion blogger from Indonesia. The research used the qualitative method with data collection by virtual observation from June until August 2016. Rikasari’s personal branding showed on her blog was the fashionably smart woman who had entrepreneurship competence. This research finds out that Diana Rikasari success to make her personal identity by her blog profile and blog posting. Her positioning is clear as Indonesian modern woman. The personal brand assessment can be seen through the achievements and feedbacks on her blog post, both positive or negative.

  11. La microbiota intestinal : un nuevo factor para prevenir la obesidad y la diabetes

    OpenAIRE

    Navarro del Cabo, Sonia

    2016-01-01

    RESUMEN: La obesidad y la diabetes mellitus tipo 2 son las nuevas epidemias del siglo XXI. Ambas son atribuidas a una combinación de la susceptibilidad genética y los factores relacionados con la vida diaria. El aumento de la prevalencia de dichas enfermedades, ha requerido nuevos estudios que identifiquen otros factores causales para así desarrollar tratamientos innovadores para frenar este crecimiento exponencial. Un novedoso agente ha emergido como posible diana terapéutica, la microbio...

  12. United States Military Academy: 25 Years of Enlightening Research. 2012 Program Review

    Science.gov (United States)

    2012-01-01

    metal transfer data was performed at University of Central Florida. References [1] Cremers , D.A., and Radziemski, L.J., History and Fundamentals of...Cambridge University Press: New York. [2] Cremers , D.A., and Chinni, R.C., Laser-Induced Breakdown Spectroscopy- Capabilites and Limitations...Wagner, David A. Nash, Brian Gollsneider, Thomas R. Moore, Anthony J. Megofna, Timothy J. Talty, James R. Loy, Gregory B. Tait, Diana Thomas, Daniel M

  13. ERP correlates of source memory: Unitized source information increases familiarity-based retrieval

    OpenAIRE

    Diana, Rachel A.; Van den Boom, Wijnand; Yonelinas, Andrew P.; Ranganath, Charan

    2010-01-01

    Source memory tests typically require subjects to make decisions about the context in which an item was encoded and are thought to depend on recollection of details from the study episode. Although it is generally believed that familiarity does not contribute to source memory, recent behavioral studies have suggested that familiarity may also support source recognition when item and source information are integrated, or “unitized”, during study (Diana, Yonelinas, and Ranganath 2008). However,...

  14. Aire Saludable en los centros sanitarios de Asturias. Programa Marco

    OpenAIRE

    Bruno, Julio; Mosquera, Carmen

    2016-01-01

    Impreso en papel alto gramaje. 23 paginas más las portadas. INDICE Introduccion Proposito Objetivos Poblacion Diana Implantacion del Programa Ordenacion de espacios y limitacion del consumo de tabaco Potenciar las actitudes de los sanitarios hacia el abandono Otras actuaciones Evaluacion Bibliografia Hospital sin humo. Consulta preingreso Carta europea de los Hospitales sin humo ANEXO: Legislacion Framework Programme to establish smoke -free envir...

  15. Complexity Leadership Theory: A United States Marine Corps Historical Overlay

    Science.gov (United States)

    2017-05-25

    DD-MM-YYYY) 23-04-2017 2. REPORT TYPE Master’s Thesis 3. DATES COVERED (From - To) JUN 2016 – MAY 2017 4. TITLE AND SUBTITLE Complexity...Monograph Title : Complexity Leadership Theory : A United States Marine Corps Historical Overlay Approved by...General Ridgway’s Success in Korea.” Master’s thesis , United States Army Command and General Staff College, 2010. Diana, Gabriel. “Vision, Education

  16. Predicción del riesgo individual de alto coste sanitario para la identificación de pacientes crónicos complejos

    Directory of Open Access Journals (Sweden)

    Jordi Coderch

    2014-07-01

    Conclusiones: El consumo sanitario elevado se relaciona con la morbilidad crónica compleja. Un modelo basado en la edad, la morbilidad y la utilización previa es válido para predecir el riesgo de alto consumo, y así identificar la población diana de estrategias de atención proactiva para pacientes crónicos complejos.

  17. The Effect of Lavender Aaromatherapy on the Pain Intensity Perception and Intarapartum Outcomes in Primipare

    OpenAIRE

    N Alavi; M Nemati; M Kaviani; MH Tabaie

    2010-01-01

    1.Borli S, Diana SK. Easy Labour by Lamas Method, translation: Zein Ali Bagha E. 1st ed. Tehran: Babazadeh 1382:2. 2.Hadi N. Mother & Child Health . 1st ed. Shiraz: Navid13849. 3.Hosseinpour N. Acupuncture & tens on severity primiparous women's labour pain reffers to zeinabieh hospital of shiraz . MS thesis of nursing & midwifery college of shiraz university of medical sciences, Shiraz,1386. 4.Shariat MA, Mohammadian Mohamad A, Mahmodi M. The effect of request of pregnant women ...

  18. The Real Place of a Princess: Public Response

    Directory of Open Access Journals (Sweden)

    Lobna M. Shaddad

    2014-05-01

    Full Text Available The late Princess Diana of Wales (1961-1997 is one of the leading figures in the twentieth century. She used her fame as a British royal member to shed light on important humanitarian issues such as helping the homeless people, fighting against AIDS, donating money to cancer patients, supporting diseased children, and banning landmines. Her life has proven that she is one of the few celebrities who care for people; especially those in dire need. This is why she earned titles like ‘queen of people’s hearts’, ‘people’s princess’ and ‘England’s rose’. Diana’s death in a car accident has shocked the world and put it in great grief. The accident is considered by her public to be a terrible tragedy. This paper attempts to shed light on the emotional response that followed the princess’s death by studying twenty poems that were produced after her sudden death. Such poems reflect the huge influence that Princess Diana had and still has till this moment on the British way of life and thinking. The poems also assure that the real place of Diana is in her people’s hearts and memories. They also make it obvious that the sky is a better place for her; to be away from oppression and suffering. This paper will also apply the five stages of grief introduced by the psychiatrist Elisabeth Kübler-Ross to the poems in order to uncover the reasons behind giving Princess Diana such saint-like position by the public.

  19. A Novel Field-Deployable Point-of-Care Diagnostic Test for Cutaneous Leishmaniasis

    Science.gov (United States)

    2016-10-01

    operations. Thousands of cases of visceral and cutaneous leishmaniasis occurred in soldiers in World Wars I and II. Military training and combat operations...Puplampu, NAMRU-3 o Dr. Diana Carolina Gallego, CIDEIM, Colombia o Blgist. Jose Luis Malaga, UPCH-UTMB  This 05-days workshop consisted of 02 days of...mechanism is used in this project to detect cutaneous leishmaniasis, a parasite that has plagued US soldiers during the war on terror, the technology can

  20. Systems Engineering Analysis for Office Space Management

    Science.gov (United States)

    2017-09-01

    ENGINEERING ANALYSIS FOR OFFICE SPACE MANAGEMENT by James E. Abellana September 2017 Thesis Advisor: Diana Angelis Second Reader: Walter E. Owen...Master’s thesis 4. TITLE AND SUBTITLE SYSTEMS ENGINEERING ANALYSIS FOR OFFICE SPACE MANAGEMENT 5. FUNDING NUMBERS 6. AUTHOR(S) James E. Abellana 7...of the systems engineering method, this thesis develops a multicriteria decision-making framework applicable to space allocation decisions for

  1. Large Scale Hierarchical K-Means Based Image Retrieval With MapReduce

    Science.gov (United States)

    2014-03-27

    flat vocabulary on MapReduce. In 2013, Moise and Shestakov [32, 40], have been researching large scale indexing and search with MapReduce. They...time will be greatly reduced, however image retrieval performance will almost certainly suffer. Moise and Shestakov ran tests with 100M images on 108...43–72, 2005. [32] Diana Moise , Denis Shestakov, Gylfi Gudmundsson, and Laurent Amsaleg. Indexing and searching 100m images with map-reduce. In

  2. Livres | Page 10 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    African Urban Harvest : Agriculture in the Cities of Cameroon, Kenya and Uganda. Au cours des deux dernières décennies, comment l'agriculture urbaine a-t-elle évolué dans les pays de l'Afrique subsaharienne ? Directeur(s) : Gordon Prain, Nancy Karanja, et Diana Lee-Smith. Maison(s) d'édition : Springer, CIP, CRDI.

  3. Talking in the Ranks: Gender and Military Discourse

    Science.gov (United States)

    2005-04-29

    work of Pierre Bourdieu (1991) is important here on at least two counts which I explain in more depth below: his concepts of "habitus" and "rites of...Upper Saddle River, NJ: Prentice Hall. Bourdieu , Pierre . 1991. Language and Symbolic Power. Cambridge, Mass: Harvard University Press. Boxer, Diana and...institutions". Bourdieu revived the Aristotelian concept of the habitus, interpreted as the set of "dispositions which incline agents to act or react in

  4. Army AL&T, July-September 2008

    Science.gov (United States)

    2008-09-01

    Northern Region — Wanda Reed (PCO), Joann Langston (PARC), Debbie Emerson (Alt. to PARC) Southern Region — Julie Silva (PCO), Carol Lowman (Direc- tor/PARC...Charles Jaber (PCO), Roger Engebretson, (Director/PARC), Sharon Oishi (Alt. to PARC) U.S. Army Contracting Command, Southwest Asia — Carol Estes (PCO...Robyn Villafranco, Margarita Ramirez, Diana Fernandez, Donna Reed, Michely Walton, Elisa Mendez , Cynariah Wilkins, Deinor Bolanos, Belinda Kent

  5. Beyond Sister City Agreements: Exploring the Challenges of Full International Interoperability

    Science.gov (United States)

    2016-03-01

    Mexican-American Attitudes toward Mexico,” International Migration Review 32, no. 2 ( Summer 1998). 36 de la Garza and DeSipio, “Interests Not Passions...Daily Times, October 7, 2014, 2. 44 Diana L. Haytko, John L. Kent, and Angela Hausman , “Mexican Maquiladoras: Helping or Hurting the US/Mexico...standing of a local player in a regional game. These interoperable agreements make sense from a political 175 Lawrence Freedman, Strategy-A History (New

  6. Brava gente brasileira e o "Brasil 500": o espetáculo do descobrimento

    OpenAIRE

    Bezerra, Kátia da Costa

    2011-01-01

    Tendo por base os estudos de Diana Taylor, Anthony Pagden e Jean Starobinski, este ensaio analisa a forma como o fi lme Brava gente brasileira dramatiza alguns dos confl itos presentes na reencenação da descoberta durante os festejos do “Brasil 500”. O propósito é refl etir sobre alguns dos intertextos envolvidos no processo de construção de um sentido de brasilidade.

  7. Hemerografía

    Directory of Open Access Journals (Sweden)

    Revista Chasqui

    2015-01-01

    Full Text Available Cine, revista de apreciación cultural y cinematográfica, Nº 3, Ecuador, Diciembre 1984; Comunicación y cultura, octubre de 1984, México Nº 12; Arcadia va al cine, Año 3, Nº 8, octubre de 1984; La droga que se enchufa, La televisión, los niños y la familia, Marie Winn, Editorial Diana, México 1981; Communications et langages, Revista trimestral, Año 1984.

  8. Rembrandt Kadrioru lossis / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2000-01-01

    Kadrioru lossi kuppelsaali tundmatu meistri laemaali maalimise ajalugu. Maali aluseks on Rembrandti maal "Diana suplus". Laemaal on maalitud Magdalena de Passe (1600-1638) vasegravüüri põhjal, mis on tehtud Rembrandti maalist. Rembrandt on lähtunud Antonio Tempesta (1555-1630) kahest gravüürist, viimane on lähtunud Otto van Veeni (1556-1629) maalist

  9. PARENTING AND ITS INFLUENCE ON CHILD BEHAVIOUR

    OpenAIRE

    Jiji Mary Antony; Suresh Sebastian Vadakedom

    2017-01-01

    BACKGROUND Parenting is the process of giving care to the young and preparing them to face the challenges of life. Diana Baumrind introduced the models of parenting, authoritative, authoritarian and permissive depending on the level of demandingness and responsiveness. Defective parenting is associated with problem behaviours in children. This study was undertaken to find out which parenting style is least associated with behavioural problems and what are the problems associated w...

  10. Proceedings of Conference on Language Documentation and Linguistic Theory 3

    OpenAIRE

    Austin, PK

    2011-01-01

    A collection dealing with language documentation and linguistic theory from a conference held at SOAS on 19- 20 November 2011. Papers by Peter Austin, Oliver Bond, Lutz Marten & David Nathan, Balthasar Bickel, Anju Saxena, Anvita Abbi, Cathryn Bartram, Henrik Bergqvist, Martine Bruil, Eliane Camargo & Sabine Reiter, Kearsy Cormier, Jordan Fenlon, Ramas Rentelis, & Adam Schembri, Simeon Floyd & Martine Bruil, Diana Forker, Michael Franjieh & Kilu von Prince, Brent Henderson & Charl...

  11. Analisis Pemasaran Ayam Ras Pedaging di Pasar Tradisional Kota Medan

    OpenAIRE

    Fachri, Yusrizal

    2017-01-01

    130306044 YUSRIZAL FACHRI, 2017. “Analisis Pemasaran Ayam Ras Pedaging di Pasar Tradisional Kota Medan”. Dibimbing oleh ARMYN HAKIM DAULAY dan NEVY DIANA HANAFI. Penelitian ini bertujuan untuk mengidentifikasi karakteristik lembaga pemasaran, bentuk saluran, fungsi pemasaran, dan menganalisis nilai tambah di lembaga-lembaga pemasaran ayam ras pedaging di pasar tradisional Kota Medan pada April sampai Mei 2017. Penelitian ini menggunakan data primer yang didapatkan dari observasi dan waw...

  12. Climate Change: Causes, Consequences, and How to Respond

    OpenAIRE

    Liverman, Diana; MacDonald, Glen

    2009-01-01

    Diana Liverman explores the theoretical positions for reducing greenhouse gas emissions including “earth-system management”, cap and trade policies, individual and community behavioral change, political economy of carbon governance (“carbon capitalism”), and government regulation and incentives. She supports a blending of the last three to produce “political ecology”. Liverman is critical of the Kyoto Accords but argues in favor of the Clean Development Mechanism [CDM] with some significant a...

  13. The accumulation and management of pharmaceutical waste in the community pharmacy

    OpenAIRE

    Latožienė, Rima

    2017-01-01

    The Accumulation and Management of Pharmaceutical Waste in the Community Pharmacy Authors: students Diana Patašienė and Rima Latožienė, pharmacy master program at Vilnius University Faculty of Medicine, Department of Pathology, Forensic Medicine and Pharmacology. Work Leader: Dr. Kristina Garuolienė. The aim of the study: to determine pharmaceutical waste formation causes and to assess pharmaceutical waste management problems at community pharmacies. Materials and methods: The study was condu...

  14. Large scale experiments with a 5 MW sodium/air heat exchanger for decay heat removal

    International Nuclear Information System (INIS)

    Stehle, H.; Damm, G.; Jansing, W.

    1994-01-01

    Sodium experiments in the large scale test facility ILONA were performed to demonstrate proper operation of a passive decay heat removal system for LMFBRs based on pure natural convection flow. Temperature and flow distributions on the sodium and the air side of a 5 MW sodium/air heat exchanger in a natural draught stack were measured during steady state and transient operation in good agreement with calculations using a two dimensional computer code ATTICA/DIANA. (orig.)

  15. Novel in situ self-assembly nanoparticles for formulating a poorly water-soluble drug in oral solid granules, improving stability, palatability, and bioavailability

    OpenAIRE

    Dong, Xiaowei; Guo,Shujie; Pham,Kevin; Li,Diana; Penzak,Scott

    2016-01-01

    Shujie Guo,1 Kevin Pham,2 Diana Li,2 Scott R Penzak,3 Xiaowei Dong2 1State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Pharmaceutical Sciences, 3Department of Pharmacotherapy, University of North Texas Health Science Center, Fort Worth, TX, USA Purpose: The purpose of this study was to develop a novel lipid-based nanotechnology to...

  16. Draft Environmental Impact Statement. Peacekeeper in Minuteman Silos, 90th Strategic MIssile Wing, F. E. Warren Air Force Base

    Science.gov (United States)

    1983-10-01

    P. Miles Kathleen Talgoom Kimball, NE Green River, WY Paul A. Moyer Joann Tall Timnath, CO Porcupine , SD Diana Savoy-Marcos Frances Towner Wheatland...during more than one season, but is most important to the herd during winter. Big Game Winter-Yearlong Habitat: habitat occupied by animals during...more than one season, but is most important to the herd during winter. Big Game Yearlong Habitat: includes areas where all or part of a herd is found

  17. Noort moodi / Kätlin Karik

    Index Scriptorium Estoniae

    Karik, Kätlin

    2011-01-01

    ERKI Moeshow Volta tehases 4. juunil 2011. Loetletud lavale pääsenud kollektsioonid. Pikemalt kollektsioonidest "All that money" (Madis Luik, Karen Milistver, Nele Aunap), "Satellite orchids" (Olga Jazepova), "Vaktsiin" (Triinu Jõhve, Diana Tombak, Katrina Kaubi, Maarja Siim, Piret Mägi, Elina Peippo), "I love you...me neither" (Olga Rattik), "Haute sport couture" (Kristina Tatarinova). Kollektsioonide autorid vastavad kolmele küsimusele

  18. Accurate microRNA target prediction correlates with protein repression levels

    Directory of Open Access Journals (Sweden)

    Simossis Victor A

    2009-09-01

    Full Text Available Abstract Background MicroRNAs are small endogenously expressed non-coding RNA molecules that regulate target gene expression through translation repression or messenger RNA degradation. MicroRNA regulation is performed through pairing of the microRNA to sites in the messenger RNA of protein coding genes. Since experimental identification of miRNA target genes poses difficulties, computational microRNA target prediction is one of the key means in deciphering the role of microRNAs in development and disease. Results DIANA-microT 3.0 is an algorithm for microRNA target prediction which is based on several parameters calculated individually for each microRNA and combines conserved and non-conserved microRNA recognition elements into a final prediction score, which correlates with protein production fold change. Specifically, for each predicted interaction the program reports a signal to noise ratio and a precision score which can be used as an indication of the false positive rate of the prediction. Conclusion Recently, several computational target prediction programs were benchmarked based on a set of microRNA target genes identified by the pSILAC method. In this assessment DIANA-microT 3.0 was found to achieve the highest precision among the most widely used microRNA target prediction programs reaching approximately 66%. The DIANA-microT 3.0 prediction results are available online in a user friendly web server at http://www.microrna.gr/microT

  19. Análisis de los cambios epigenéticos en la metilación del DNA inducidos por la diabetes y sus posibles mecanismos

    OpenAIRE

    Perna Chaux, Angelina

    2016-01-01

    Los cambios epigenéticos son responsables de la aparición de muchas patologías humanas y sus causas son debido a factores ambientales como genéticos. Se ha descrito en enfermedades crónicas como la Diabetes Mellitus tipo 2 (T2DM) que se caracteriza por los estados de hiperglucemia y el incremento en el estrés oxidativo que conlleva a complicaciones micro y macro vasculares, asociado a una desmetilación global del genoma. Nuestra hipótesis corresponde a que los órganos diana son afectados por ...

  20. Dos novelas colombianas olvidadas

    Directory of Open Access Journals (Sweden)

    Eduardo García Piedrahita

    1980-06-01

    Full Text Available Estas dos novelas olvidadas llevan por títulos Pax de don Lorenzo Marroquín (pr. edi. 1907, y Diana Cazadora de don Clímaco Soto Borda(pr. edi. 1917, ambos bogotanos aunque de disímiles estirpes literarias; y como tales en sus obras fluyen física y verbalmente, el ambiente de su ciudad natal; espíritu hecho de zumbona crítica, individualismo cáustico y solapada parodia de usos y costumbres. Y sobre tales bases sentimentales y estilísticas debe considerárselas.

  1. Functional responses of pre- and postsynaptic dopamine D2 receptors in rat brain striatum

    OpenAIRE

    Ma, Guofen

    2014-01-01

    El sistema dopaminèrgic has estat molt estudiat en els darrers anys, principalment degut a la seva implicació en diverses patologies com la malaltia de Parkinson, la esquizofrènia o la síndrome de Tourette, així com també en l'abús de drogues. S'han descrit cinc subtipus de receptors per la dopamina (DA), tots els quals pertanyen a la família de receptors acoblats a proteïnes G (GPCRs). D'aquests cinc subtipus, els receptors D2 son la diana principal dels antipsicòtics (antagonistes) i també ...

  2. Valoración del estado nutricional de un cupo pediátrico. Conociendo el punto de partida

    OpenAIRE

    Braña Ferrer, Ana

    2017-01-01

    El sobrepeso y obesidad han aumentado en las últimas décadas, como ya ha alertado la OMS, siendo un factor de riesgo para la enfermedad adulta pero también condicionando un deterioro de salud durante la infancia El objetivo de este estudio es conocer el estado nutricional y parámetros asociados en los menores de 14 años de un cupo pediátrico urbano con el fin de establecer grupos prioritarios de intervención. Métodos: estudio descriptivo retrospectivo transversal. Población diana: 719 niño...

  3. Kazuistika pacienta s Guillain - Barré syndromem

    OpenAIRE

    Dvořáková, Diana

    2013-01-01

    Title of the thesis: Case report of a patient with a diagnosis of Guillain - Barré syndrome Author: Diana Dvořáková Aim of the work: The objective of the general work is to summarize knowledge about Guillain-Barre syndrome. The objective of special work is the case report processing .This part of the work decsribes possible rehabilitaion process and evaluates effect of the choosen therapeutic methods of the patient with this disease. Method of work: This thesis has been worked up on the basis...

  4. DEVELOPMENT OF MULTIMEDIA-BASED INSTRUCTIONAL OF NATURAL SCIENCE IN SOLAR SYSTEM MATERIAL IN THE GRADE IX FOR HEARING IMPAIRMENT STUDENTS

    Directory of Open Access Journals (Sweden)

    Nurvita Dwi Andriani

    2016-12-01

    Full Text Available Hearing impairment students have limitation in obtaining information. Hearing impairment students needs a multimedia-based instructional to visualize a subject matter as a learning experience. This study was aimed at producing a theoretically and empirically valid multimedia-based instructional of Natural Science in Solar System material which is reviewed by experts and could be implemented in Segment B of SMPLB (Hearing impairment students. This study employed a research and development (R&D model by William W. Lee and Diana L. Owens. Overall, the multimedia-based instructional of Natural Science in Solar System material for Segment B of SMPLB (Hearing impairment students was valid

  5. Estilos de crianza en familias nucleares con hijos únicos

    OpenAIRE

    Quezada Fernández, Juan Carlos

    2015-01-01

    La Teoría clásica de Diana Baumrind plantea tres estilos de educación familiar, a partir de ella se pretende conocer los estilos educativos de las familias nucleares con un solo hijo, y relacionar estos estilos de crianza con la estructura familiar: jerarquía límites y alianzas. El estudio fue cuantitativo y cualitativo, las variables dependientes fueron los estilos de educación familiar, las variables independientes la estructura familiar. La selección de la muestra se realizó desde la ...

  6. Los sistemas de información para el cuadro de mando integral en pequeñas y medianas empresas industriales en Maracaibo - Estado Zulia.

    OpenAIRE

    Kunath, Irene; Alizo, María Alexandra; Graterol, Angela

    2008-01-01

    Presentación. Presentation. Rengifo, Diana Economía / Economy: Los sistemas de información para el cuadro de mando integral en pequeñas y medianas empresas industriales en Maracaibo - estado Zulia. The systems of information for the of integral control design in small and medium companies industrial in Maracaibo, Zulia state. Kunath Irene; Alizo, María Alexandra; Graterol, Angela. Educación / Education: Los hipermapas. Alternativa pedagógica y didáctica para la...

  7. Factores diagnósticos endoscópicos y pronósticos relacionados con el Helicobacter Pylori en la enfermedad injerto contra huésped tras el trasplante alogénico de células hematopoyéticas

    OpenAIRE

    Velasco Guardado, Antonio

    2016-01-01

    [ES] INTRODUCCIÓN: El trabajo consta de tres artículos originales relacionados por un lado con el diagnóstico endoscópico e histológico en la Enfermedad de Injerto contra Huésped (EICH) tras el trasplante alogénico de células hematopoyéticas (TACH) y por otro sobre el papel que juega la infección por Helicobacter pylori (HP) en dicha enfermedad. El tracto gastrointestinal es la principal diana de la Enfermedad de Injerto contra Huésped. Su diagnóstico se basa en los hallazgos endoscópicos e ...

  8. Analysis of Movie I am not Stupid 2: Parenting Style

    OpenAIRE

    Mariana

    2015-01-01

    This paper, through Singaporean movie I am not Stupid 2, analyzes the relation between parenting and childrens growth process and also the action of parents should do to offer children for having a good growth process. Research was done based on Baumrind theory about parenting analysis to what kind of parenting that the parents of the movie I am not Stupid 2 offer to their children. Research used literature study to summarize, arrange, and analyze of Diana Baumrind as basis of the research. T...

  9. Analysis of Movie I Am Not Stupid 2: Parenting Style 分析《小孩不笨2》电影的父母教育法

    OpenAIRE

    Mariana, Mariana

    2015-01-01

    This paper, through Singaporean movie I am not Stupid 2, analyzes the relation between parenting and children’s growth process and also the action of parents should do to offer children for having a good growth process. Research was done based on Baumrind theory about parenting analysis to what kind of parenting that the parents of the movie I am not Stupid 2 offer to their children. Research used literature study to summarize, arrange, and analyze of Diana Baumrind as basis of the research. ...

  10. Violencia contra las mujeres : Barreras en el ejercicio de Derechos en tensión con las normativas vigentes

    OpenAIRE

    López, Carlos Javier

    2013-01-01

    El presente trabajo reflexiona acerca de lo que Diana Maffia expresa como barreras culturales, epistémicas, políticas, subjetivas y jurídicas que constituyen obstáculos en el ejercicio de derechos de las mujeres. Se analizarán ciertas tensiones que se establecen entre normativas internacionales, nacionales y provinciales vigentes en relación con las barreras mencionadas. Finalmente se pondrán en visibilidad la lucha de los movimientos feministas y de mujeres introduciendo un aspecto que resul...

  11. Alternativas de abordaje de la depresión en atención primaria : intervenciones farmacológicas

    OpenAIRE

    Lou Arnal, Salvador

    2006-01-01

    El desarrollo de fármacos antidepresivos ha avanzadonotablemente desdeelhallazgocasual, a fines de la década de los 50,deefectosantidepresivos en fármacosinicialmente investigados para otras indicaciones (iproniazida, imipramina), hasta la aparición a partir de la década de los 80 de fármacos de síntesis diseñados para interactuar de forma específica con determinadas dianas terapéuticasmoleculares. Este desarrollo racional de antidepresivos ha sido posible por un mejor conocimiento de las alt...

  12. Wytrzymałość biegowa i pływacka studentów UKW Bydgoszcz = Speeding and swimming endurance of students UKW Bydgoszcz

    OpenAIRE

    Diana Gwiździel; Mirosława Cieślicka; Walery Zukow

    2016-01-01

    Gwiździel Diana, Cieślicka Mirosława, Zukow Walery. Wytrzymałość biegowa i pływacka studentów UKW Bydgoszcz = Speeding and swimming endurance of students UKW Bydgoszcz. Journal of Education, Health and Sport. 2016;6(8):489-503. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.60941 http://ojs.ukw.edu.pl/index.php/johs/article/view/3782       The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). ...

  13. Wytrzymałość biegowa i pływacka studentów UKW Bydgoszcz = Speeding and swimming endurance of students UKW Bydgoszcz

    OpenAIRE

    Gwiździel, Diana,; Cieślicka, Mirosława; Zukow, Walery

    2016-01-01

    Gwiździel Diana, Cieślicka Mirosława, Zukow Walery. Wytrzymałość biegowa i pływacka studentów UKW Bydgoszcz = Speeding and swimming endurance of students UKW Bydgoszcz. Journal of Education, Health and Sport. 2016;6(8):489-503. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.60941 http://ojs.ukw.edu.pl/index.php/johs/article/view/3782 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). ...

  14. Estudio de la interacción entre cuádruplex teloméricos y ligandos implicados en cáncer por SPR

    OpenAIRE

    Chaves Arquero, Belén; Santiveri, Clara M.; Campos Olivas, Ramón

    2015-01-01

    Los telómeros son considerados dianas terapéuticas ya que el mantenimiento de su secuencia por parte de la telomerasa es lo que caracteriza la inmortalidad de las células cancerígenas. Inicialmente, las estrategias terapéuticas se basaban en la telomerasa. En cambio, actualmente se están desarrollando estrategias centradas en los componentes que forman el telómero (shelterinas), como la proteína TRF1. Ensayos in vivo han demostrado que moléculas pequeñas consideradas como inhibidores de TRF1,...

  15. A computer graphics based model for scattering from objects of arbitrary shapes in the optical region

    Science.gov (United States)

    Goel, Narendra S.; Rozehnal, Ivan; Thompson, Richard L.

    1991-01-01

    A computer-graphics-based model, named DIANA, is presented for generation of objects of arbitrary shape and for calculating bidirectional reflectances and scattering from them, in the visible and infrared region. The computer generation is based on a modified Lindenmayer system approach which makes it possible to generate objects of arbitrary shapes and to simulate their growth, dynamics, and movement. Rendering techniques are used to display an object on a computer screen with appropriate shading and shadowing and to calculate the scattering and reflectance from the object. The technique is illustrated with scattering from canopies of simulated corn plants.

  16. Uus plaat

    Index Scriptorium Estoniae

    2004-01-01

    Uutest plaatidest Janet Jackson "Damita Jo", N.E.R.D. "Fly or Die", Oleg pissarenko Trio "The Little One's", "Dance Express", Neiokõsõ "Tii", Agnetha Fältskog "My Colouring Book", Diana Krall "The Girl In The Other Room", Hedvig Hanson & Andre Maaker "Nii õrn on öö", "D12 world", Blank&Jones "Monument", "Rock Ballads", "The Passion of The Christ", "Anastacia", "Kill Bill. Vol.2", Metro Luminal "Coca Cola, "No-Big-Silence & Kosmikud", Londonbeat "The very Best Of"

  17. Esther Schor, ed. The Cambridge Companion to Mary Shelley

    Directory of Open Access Journals (Sweden)

    Anne BERTON

    2006-06-01

    Full Text Available “Today, whether she is found between staid cloth covers, in paperback, on the screen or in cyberspace, Mary Shelley is everywhere,” writes Esther Schor in her Introduction to this collection of essays (2. Interest in “the Author of Frankenstein” and of other works has grown steadily over the last twenty years, thanks notably to the publication of her Journals (The Journals of Mary Shelley, 1814-1844, ed. Paula R. Feldman and Diana Scott-Kilvert, 2 vols, Oxford: Clarendon, 1987, of her Lette...

  18. Interaction of opioid and Notch signaling cascades. Implications in dopaminergic development after morphine administration

    OpenAIRE

    García Concejo, Adrián

    2017-01-01

    [ES]El análisis de la cascada de señalizacion molecular activada por la morfina puede permitir el descubrimiento de nuevas dianas terapéuticas que puedan ser usadas para paliar los efectos derivados del uso de opioides, Los receptores opioides han sido ampliamente estudiados, y su regulación después de su activación podría explicar las bases moleculares de la adicción. De entre todos los cambios ejercidos tras la administración de morfina, los cambios en los niveles de expresión de algunos mi...

  19. Valor pronóstico del análisis de marcadores moleculares mediante proteómica dirigida en cáncer de mama precoz con receptores hormonales positivos

    OpenAIRE

    Martinez del Prado, María Purificación

    2018-01-01

    Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina. Fecha de lectura: 22-03-2018 Introducción: El cáncer de mama (CM) es una enfermedad heterogénea a nivel molecular. La proteómica dirigida permite la investigación de potenciales biomarcadores, factores pronósticos, predictivos, diagnósticos y nuevas dianas terapéuticas en el cáncer de mama. En una serie inicial de pacientes (cohorte de descubrimiento) con CM, receptores hormon...

  20. Comparación de los efectos in vivo del D-003, una mezcla de ácidos de alto peso molecular obtenida de la cera de caña de azúcar y el extracto de uva sobre marcadores de peroxidación lipídica en ratas

    OpenAIRE

    Pérez, Yohani; Molina, Vivian; Más, Rosa; González, Rosa María; Jiménez, Sonia

    2008-01-01

    Los radicales libres producen efectos dañinos sobre las moléculas diana, como una incrementada peroxidación de lípidos (PL), proteínas y del ADN, lo cual puede ser inhibido o reducido por sustancias antioxidantes. El D-003 es una mezcla de ácidos de alto peso molecular obtenida de la cera de la caña de azúcar que ha mostrado inhibir la peroxidación lipídica en modelos animales y voluntarios sanos. El extracto de Uva, rico en flavonoides, ha demostrado poseer efectos antioxidantes efectivos y ...

  1. Energy Trapping, Release, and Transport in Three-Dimensional Energetic Solids and Molecular Crystals: Theory of Defects and Impurities.

    Science.gov (United States)

    1984-12-31

    and 3. T. Waber, Concerning the Trapping of Positrons in Ionic Solids, in Positron Annihilation , P. G. Coleman, S. C. Sharma and L. M. Diana, Eds., 682...1982). *144. A. B. Kunz and 3. T. Waber, A Theoretical Study of the Binding of Positrons to Gaseous Molecules, in Positron Annihilation . P. G. Coleman, S...variety of other cases which include systems in unusual charge states such as Fe + in SrTiOz or Fe in MgO . Impurity systems in their excited states are

  2. ¿Más allá de la postmodernidad?: ‘Countdown’, Beyoncé y Keersmaeker

    OpenAIRE

    Sanjuán Astigarraga, José Ignacio

    2017-01-01

    La cantante americana Beyoncé utiliza en el videoclip de la canción Countdown elementos de dos coreografías de Anna Teresa De Keersmaeker. El presente texto intenta establecer qué elementos toma Beyoncé de las obras de Keersmaeker y cómo se relaciona esta apropiación con otras imágenes (Audrey Hepburn, Diana Ross) que también aparecen en el vídeo American singer Beyoncé used in the music video for the song Countdown elements of two choreographies by Anna Teresa De Keersmaeke...

  3. Evaluation of one dimensional analytical models for vegetation canopies

    Science.gov (United States)

    Goel, Narendra S.; Kuusk, Andres

    1992-01-01

    The SAIL model for one-dimensional homogeneous vegetation canopies has been modified to include the specular reflectance and hot spot effects. This modified model and the Nilson-Kuusk model are evaluated by comparing the reflectances given by them against those given by a radiosity-based computer model, Diana, for a set of canopies, characterized by different leaf area index (LAI) and leaf angle distribution (LAD). It is shown that for homogeneous canopies, the analytical models are generally quite accurate in the visible region, but not in the infrared region. For architecturally realistic heterogeneous canopies of the type found in nature, these models fall short. These shortcomings are quantified.

  4. Playing by the rules. The Hague courts and the Acteonisation du Grand Veneur d’Hollande (1643

    Directory of Open Access Journals (Sweden)

    Marika Keblusek

    2017-02-01

    Full Text Available This article discusses an unpublished play, Acteonisation du Grand Veneur d’Hollande (1643. Created – and possibly performed – within the immediate circle of the court of Elizabeth of Bohemia in The Hague, its anonymous author satirizes the various personalities in the Orange courts of respectively Frederik Hendrik and Amalia von Solms, and Willem II and Mary Stuart. Focusing on the social ambitions of Johannes Polyander van Kerckhoven, Lord of Heenvliet, and by using the popular myth of Actaeon and Diana, the clash between court and city, between princely aristocrats and republican burghers is played out.

  5. Proceedings of Patient Reported Outcome Measure?s (PROMs) Conference Sheffield 2016: advances in patient reported outcomes research

    OpenAIRE

    Croudace, Tim; Brazier, John; Gutacker, Nils; Street, Andrew; Robotham, Dan; Waterman, Samantha; Rose, Diana; Satkunanathan, Safarina; Wykes, Til; Nasr, Nasrin; Enderby, Pamela; Carlton, Jill; Rowen, Donna; Elliott, Jackie; Brazier, John

    2016-01-01

    Table of contents S1 Using computerized adaptive testing Tim Croudace S2 Well-being: what is it, how does it compare to health and what are the implications of using it to inform health policy John Brazier O1 “Am I going to get better?”—Using PROMs to inform patients about the likely benefit of surgery Nils Gutacker, Andrew Street O2 Identifying Patient Reported Outcome Measures for an electronic Personal Health Record Dan Robotham, Samantha Waterman, Diana Rose, Safarina Satkunanathan, Til W...

  6. Síntesis de Protoberberinas y Ciclopentil-isoquinoleínas Dopaminérgicas, y Síntesis de Indenopiridinas Melatoninérgicas

    OpenAIRE

    Párraga Vidal, Javier

    2015-01-01

    Resumen – Discusión de los resultados. En la presente Tesis Doctoral se han desarrollado diversas rutas de síntesis para la obtención de alcaloides isoquinoleínicos, con diferentes esqueletos, y de hexahidroindenopiridinas. Además se han realizado sus correspondientes ensayos farmacológicos, sobre distintas dianas biológicas basándonos en los resultados obtenidos previamente con este tipo de alcaloides de síntesis y/o aislados de la naturaleza, y de moléculas estructuralmente similares. Se...

  7. Mosquitos (Diptera: Culicidae) de los parques naturales de la Comunidad Valenciana

    OpenAIRE

    Bernués Bañeres, Alberto

    2013-01-01

    La familia Culicidae incluye algunas de las especies de dípteros más relevantes en el ámbito de la Salud Pública, no solo por las molestias que son capaces de causar debido a su tipo de alimentación hematófaga, sino por su capacidad para actuar como vectores de enfermedades de afección humana. Por este motivo, los mosquitos han sido, desde siempre, una de las dianas predilectas en los programas de control establecidos para la regulación de sus poblaciones y, por tanto, como medida profiláctic...

  8. The FARC a way into new wars

    Directory of Open Access Journals (Sweden)

    José Fernando Valencia Grajales

    2011-07-01

    Full Text Available This text, first comparing the FARC with the texts of Mao Tse-Tung, Strategic Issues in Guerrilla War Against Japan, with Diana Hernández Hoyos, International Humanitarian Law: How and why to apply international humanitarian law to the law and the internal conflict in Colombia, also Mary Kaldor, New Wars, Chapter 2 and 3, with Peter Waldman and Fernando Reinares, in companies in the Civil War, Chapter 1 and 3, and also that of Eduardo Pizarro Leon Gomez. The FARC, Defense to the Combination of All Forms of Struggle. Chapter 1, second in the comparisons were attempted an analysis of the historical circumstances, to finely make conclusions

  9. Evaluación de la patogenicidad en ratas del Paecilomyces lilacinus LPL-01 utilizando vías diferentes de exposición

    OpenAIRE

    A Mancebo; F González Menció; B González Navarro; L Riera; S Lugo; AM Bada; L Aldana; Y González Torres; ME Arteaga; D Fuentes

    2005-01-01

    Los nemátodos parásitos de las plantas, conocidos como plagas agrícolas desde el siglo XIX, causan un 9% de pérdidas de cultivos en los países desarrollados y un 14% en los países en desarrollo. El Paecilomyces lilacinus es un hongo parásito que ataca formas sedentarias de los nemátodos, como los huevos. Su valoración como agente microbiano de control debe incluir una evaluación de su virulencia hacia organismos no-diana, tomando en consideración las vías posibles de expo...

  10. Terapia génica en el cáncer de próstata: ¿Es posible una vacuna?

    OpenAIRE

    Gómez Pérez, L.; Delgado Oliva, F.J.; Vera Donoso, C.D.; Jiménez Cruz, J.F.; Hernández Andreu, J.M.

    2007-01-01

    Introducción: Debido a las limitaciones existentes en el tratamiento del cáncer de próstata en estadios avanzados, se precisan nuevas estrategias de tratamiento para estos pacientes. El desarrollo de la biología molecular en el campo del cáncer de próstata, ha proporcionado un mayor conocimiento de las alteraciones más comunes a nivel del ADN de las células cancerígenas, que podrían ser utilizadas como dianas terapéuticas. En este artículo se han revisado los conceptos actuales en el campo de...

  11. Receptores de insulina en hematíes: caracterización del sistema. Estudios en pacientes obesos y con infarto de miocardio

    OpenAIRE

    Griera Borras, José Luis

    1982-01-01

    Tras la publicación a finales de 1978 por GAMBHIR y Cols. de la existencia de receptores de insulina en hematíes, iniciamos este trabajo con la idea de utilizar este tipo de célula para el estudio de la interacción insulina-receptor, ya que ofrecía “a priori” una serie de ventajas sobre los tejidos diana “clásicos” (músculo, hígado, tejido graso) y otros de más reciente adquisición (v.g. monocitos ...

  12. The LIFE Cognition Study: design and baseline characteristics

    OpenAIRE

    Sink, Kaycee M; Espeland, Mark A; Rushing, Julia; Castro, Cynthia M; Church, Timothy S; Cohen, Ronald; Gill, Thomas M; Henkin, Leora; Jennings, Janine M; Kerwin, Diana R; Manini, Todd M; Myers, Valerie; Pahor, Marco; Reid, Kieran F; Woolard, Nancy

    2014-01-01

    Kaycee M Sink,1 Mark A Espeland,2 Julia Rushing,2 Cynthia M Castro,3 Timothy S Church,4 Ronald Cohen,5 Thomas M Gill,6 Leora Henkin,2 Janine M Jennings,7 Diana R Kerwin,8 Todd M Manini,5 Valerie Myers,9 Marco Pahor,5 Kieran F Reid,10 Nancy Woolard,1 Stephen R Rapp,11 Jeff D Williamson1 On behalf of LIFE Investigators 1Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of ...

  13. Desarrollo y validación de nuevas metodologías para la caracterización de la interacción de ligandos con ADN. Estudio de la

    OpenAIRE

    García Hernández, Verónica

    2009-01-01

    El diseño de compuestos con capacidad de unión a secuencias específicas de ADN tiene gran importancia en farmacología dado que existen numerosos fármacos que tienen el ADN como diana y cuya actividad terapéutica se basa en la afinidad y selectividad de su interacción con el mismo. Por otro lado, estos ligandos de bajo peso molecular con capacidad de unión a secuencias predeterminadas de ADN pueden ser herramientas de gran utilidad en biología molecular. Para comprender en ...

  14. Science.gov (United States)

    PASSALI, D.; BENEDETTO, F.; BENEDETTO, M.; CHIARAVALLOTI, F.; DAMIANI, V.; PASSALI, F.M.; BELLUSSI, L.M.; THE WORKING GROUP

    2011-01-01

    SUMMARY In spite of the amount of literature demonstrating the relationship between upper and lower airways, both from the anatomical, and pathophysiological point of view, little is known about the epidemiology, diagnosis and treatment of the Rhino-Bronchial Syndrome (RBS). After the publication, in 2003, of a Consensus Report defining the Rhino-Bronchial Syndrome, an interdisciplinary group of experts made up from the Italian ENT Society (SIO) and the Interdisciplinary Scientific Association for the Study of Respiratory Diseases (AIMAR) met again in 2005 in order to study a protocol which would have, as the main tasks, the analysis of RBS signs and symptoms and standardization of the diagnostic approach. A secondary endpoint was to characterize the most effective therapeutic options and to correct the great dyshomogeneity in the therapeutic approaches. With this aim, 9 ENT and Pneumology Centres were selected, based on the ability to multidisciplinary cooperation, availability of useful instrumentation and homogeneous distribution over the entire National territory. Overall, 159 patients were enrolled according to clinical history (major and minor symptoms of upper and lower airways) and inclusion/exclusion criteria. All underwent a two level diagnostic approach. In 116 patients, the diagnosis was confirmed on the basis of I level (rhinopharyngeal endoscopy and basal spirometry, respectively, for upper and lower airways) examination. Allergic and infectious diseases were significantly more frequent (37.9% vs 20.9% and 73.3% vs 46.55, respectively) in patients with a confirmed diagnosis for Rhino-Bronchial Syndrome. Nasal obstruction (93%), rhinorrhoea (75%), cough (96%) and dyspnoea (69%) were the more frequent symptoms. The presence of meatal secretions or polyps were the clinical findings significantly differing at endoscopy in the two groups. After 3 months of treatment, according to "good clinical practice" (inhaled steroids, antibiotics, nasal lavages), 96

  15. Diversity and prevalence of gastrointestinal parasites in seven non-human primates of the Taï National Park, Côte d’Ivoire

    Directory of Open Access Journals (Sweden)

    Kouassi Roland Yao Wa

    2015-01-01

    Full Text Available Parasites and infectious diseases are well-known threats to primate populations. The main objective of this study was to provide baseline data on fecal parasites in the cercopithecid monkeys inhabiting Côte d’Ivoire’s Taï National Park. Seven of eight cercopithecid species present in the park were sampled: Cercopithecus diana, Cercopithecus campbelli, Cercopithecus petaurista, Procolobus badius, Procolobus verus, Colobus polykomos, and Cercocebus atys. We collected 3142 monkey stool samples between November 2009 and December 2010. Stool samples were processed by direct wet mount examination, formalin-ethyl acetate concentration, and MIF (merthiolate, iodine, formalin concentration methods. Slides were examined under microscope and parasite identification was based on the morphology of cysts, eggs, and adult worms. A total of 23 species of parasites was recovered including 9 protozoa (Entamoeba coli, Entamoeba histolytica/dispar, Entamoeba hartmanni, Endolimax nana, Iodamoeba butschlii, Chilomastix mesnili, Giardia sp., Balantidium coli, and Blastocystis sp., 13 nematodes (Oesophagostomum sp., Ancylostoma sp., Anatrichosoma sp., Capillariidae Gen. sp. 1, Capillariidae Gen. sp. 2, Chitwoodspirura sp., Subulura sp., spirurids [cf Protospirura muricola], Ternidens sp., Strongyloides sp., Trichostrongylus sp., and Trichuris sp., and 1 trematode (Dicrocoelium sp.. Diversity indices and parasite richness were high for all monkey taxa, but C. diana, C. petaurista, C. atys, and C. campbelli exhibited a greater diversity of parasite species and a more equitable distribution. The parasitological data reported are the first available for these cercopithecid species within Taï National Park.

  16. Diversity and prevalence of gastrointestinal parasites in seven non-human primates of the Taï National Park, Côte d'Ivoire.

    Science.gov (United States)

    Kouassi, Roland Yao Wa; McGraw, Scott William; Yao, Patrick Kouassi; Abou-Bacar, Ahmed; Brunet, Julie; Pesson, Bernard; Bonfoh, Bassirou; N'goran, Eliezer Kouakou; Candolfi, Ermanno

    2015-01-01

    Parasites and infectious diseases are well-known threats to primate populations. The main objective of this study was to provide baseline data on fecal parasites in the cercopithecid monkeys inhabiting Côte d'Ivoire's Taï National Park. Seven of eight cercopithecid species present in the park were sampled: Cercopithecus diana, Cercopithecus campbelli, Cercopithecus petaurista, Procolobus badius, Procolobus verus, Colobus polykomos, and Cercocebus atys. We collected 3142 monkey stool samples between November 2009 and December 2010. Stool samples were processed by direct wet mount examination, formalin-ethyl acetate concentration, and MIF (merthiolate, iodine, formalin) concentration methods. Slides were examined under microscope and parasite identification was based on the morphology of cysts, eggs, and adult worms. A total of 23 species of parasites was recovered including 9 protozoa (Entamoeba coli, Entamoeba histolytica/dispar, Entamoeba hartmanni, Endolimax nana, Iodamoeba butschlii, Chilomastix mesnili, Giardia sp., Balantidium coli, and Blastocystis sp.), 13 nematodes (Oesophagostomum sp., Ancylostoma sp., Anatrichosoma sp., Capillariidae Gen. sp. 1, Capillariidae Gen. sp. 2, Chitwoodspirura sp., Subulura sp., spirurids [cf Protospirura muricola], Ternidens sp., Strongyloides sp., Trichostrongylus sp., and Trichuris sp.), and 1 trematode (Dicrocoelium sp.). Diversity indices and parasite richness were high for all monkey taxa, but C. diana, C. petaurista, C. atys, and C. campbelli exhibited a greater diversity of parasite species and a more equitable distribution. The parasitological data reported are the first available for these cercopithecid species within Taï National Park. © R.W.Y. Kouassi et al., published by EDP Sciences, 2015.

  17. Modelos de fissuração distribuída em vigas de concreto armado pelo método dos elementos finitos

    Directory of Open Access Journals (Sweden)

    R.C.G. Menin

    Full Text Available O objetivo principal do trabalho é apresentar uma comparação entre distintas estratégias de simulação computacional de estruturas de concreto armado utilizando modelos de fissuração distribuída. Em uma primeira abordagem, foi adotado o modelo multidirecional de fissuração distribuída do programa DIANA empregando-se diferentes regras de amolecimento para o material fissurado (frágil, linear e não-lineares de Moelands-Reinhardt e de Hordijk. Posteriormente, foi utilizada a formulação DSFM - Disturbed Stress Field Model, modelando o concreto fissurado como um material ortotrópico com fissuras distribuídas do tipo rotacionais. Os programas DIANA e VecTor2 foram utilizados como ferramentas para avaliar a eficácia dos diferentes modelos no estudo de vigas de concreto armado submetidas a esforços de flexão.

  18. Glioblastoma: Análisis molecular y sus implicancias clínicas

    Directory of Open Access Journals (Sweden)

    Carlos A Castañeda

    Full Text Available El glioblastoma multiforme (GB es el tumor cerebral primario del sistema nervioso central (SNC más frecuente y más letal en la edad adulta. La evidencia epidemiológica indica que su incidencia es menor en la raza hispana. El tratamiento quirúrgico es la opción terapéutica preferente. Recientemente se han introducido nuevas estrategias que incrementan el volumen de resección. El uso de quimioterapia y radioterapia concurrentes mejora la supervivencia de los pacientes, aunque se asocia a toxicidad. La mejora en la comprensión de la biología molecular del GB ha permitido la identificación de biomarcadores predictivos de respuesta terapéutica y pronóstico, así como la identificación de dianas terapéuticas que han permitido el desarrollo de nuevas estrategias en el tratamiento de estos tumores. Entre los biomarcadores actualmente disponibles se encuentran la codelección 1p/19q, la mutación de IDH y la metilación del promotor O6- metilguanina DNA-metiltransferasa. La identificación de dianas terapéuticas permite el desarrollo de nuevas drogas y su evaluación posterior en ensayos clínicos, aunque ninguna de ellas ha sido validada prospectivamente en ensayos clínicos de fase III

  19. Bioinformatics analysis for evaluation of the diagnostic potentialities of miR-19b, -125b and -205 as liquid biopsy markers of prostate cancer

    Science.gov (United States)

    Bryzgunova, O. E.; Lekchnov, E. A.; Zaripov, M. M.; Yurchenko, Yu. B.; Yarmoschuk, S. V.; Pashkovskaya, O. A.; Rykova, E. Yu.; Zheravin, A. A.; Laktionov, P. P.

    2017-09-01

    Presence of tumor-derived cell-free miRNA in biological fluids as well as simplicity and robustness of cell-free miRNA quantification makes them suitable markers for cancer diagnostics. Based on previously published data demonstrating diagnostic potentialities of miR-205 in blood and miR-19b as well as miR-125b in urine of prostate cancer patients, bioinformatics analysis was carried out to follow their involvement in prostate cancer development and select additional miRNA-markers for prostate cancer diagnostics. Studied miRNAs are involved in different signaling pathways and regulate a number of genes involved in cancer development. Five of their targets (CCND1, BRAF, CCNE1, CCNE2, RAF1), according to the STRING database, act as part of the same signaling pathway. RAF1 is regulated by miR-19b and miR-125b, and it was shown to be involved in prostate cancer development by DIANA and STRING databases. Thus, other microRNAs regulating RAF1 expression such as miR-16, -195, -497, and -7 (suggested by DIANA, TargetScan, MiRTarBase and miRDB databases) can potentially be regarded as prostate cancer markers.

  20. “Lasso of Truth”: Rediscovering the Forgotten History of Wonder Woman

    Directory of Open Access Journals (Sweden)

    Irena Jurković

    2015-06-01

    Full Text Available In a period witnessing the increasing popularity of superhero franchises, comic book historian Tim Hanley sheds light on the forgotten history of the world’s most famous female superhero, Wonder Woman. Tim Hanley’s Wonder Woman Unbound: The Curious History of the World’s Most Famous Heroine, as its title suggests, aims to explore the curious path of Wonder Woman: from the creation of the character to her contemporary iconic status. The book is comprised of three sections that follow the eras of American comic books: Golden Age, Silver Age and Bronze Age. Hanley starts off with Wonder Woman’s origin story, associating it primarily with the life and work of her creator, psychologist William Marston. The story begins when an American pilot, Steve Trevor, crashes on the hidden Paradise Island and is found injured by Diana and her fellow Amazons. Paradise Island is the home of mythical Amazons guided by goddesses Aphrodite and Athena. Their world is an only-female utopia situated far away from the outside, violent, world of men. However, while Amazons live in peace, the outside world is bursting with war and Steve needs to return to America to fulfill his soldier duties. The Amazon goddesses decide to send a warrior, Diana, to help Steve through his journey. That warrior later becomes a superheroine known by the name of Wonder Woman.

  1. Malagasyprinus, a new genus of the Saprininae from Madagascar with description of two new species (Coleoptera, Histeridae, Saprininae (First contribution to the knowledge of the Histeridae of Madagascar

    Directory of Open Access Journals (Sweden)

    Tomáš Lackner

    2013-09-01

    Full Text Available Based on the results of recent phylogenetic analysis of the higher taxa of the Saprininae as well as external morphological characters, especially the presence of deep and large prosternal foveae, and the shape and position of the sensory organs of the antennal club, the species Saprinus (s.str. caeruleatus Lewis, 1905 is excluded from the genus Saprinus and a new genus Malagasyprinus, exclusive to Madagascar, is established for it. The new genus shows mainly characters that are apomorphic for the subfamily and contains another two, highly similar allopatric species M. perrieri sp. n., and M. diana sp. n., described herein. The three species are best separated from each other by the structure of the prosternum and male terminalia, especially the shape of the aedeagus. We re-describe M. caeruleatus comb. n. and provide M. perrieri and M. diana with brief differential diagnoses. All taxon descriptions are accompanied with color habitat photographs, SEM micrographs and drawings of their male genitalia. A key to the species of Malagasyprinus is given. Sensory structures of the antenna of M. caeruleatus comb. n. are likewise depicted herein. The systematic position of the newly erected genus is discussed. A lectotype of Saprinus caeruleatus Lewis, 1905 is designated.

  2. Caracterización de la población geriátrica hipertensa de un consultorio médico de la familia

    Directory of Open Access Journals (Sweden)

    Rafaela Yamilet Lora Martínez

    2015-02-01

    Full Text Available En los últimos años se ha incrementado la aparición de la hipertensión arterial en el adulto mayor, por lo que se realiza una investigación descriptiva transversal, para caracterizar clínica y epidemiológicamente esta entidad en los adultos mayores, atendidos en el consultorio médico de la familia (CMF No 8, perteneciente al Policlínico “Romárico Oro” de Puerto Padre, en el año 2012. La población de estudio estuvo constituida por todos los gerontes dispensarizados como hipertensos. Se analizaron las variables: factores de riesgo asociados, manifestaciones clínicas, hallazgos en exámenes complementarios y electrocardiográficos y daño en órganos diana. Dentro de los factores de riesgo asociados predominaron los antecedentes familiares de hipertensión arterial, sedentarismo y estrés. La manifestación clínica más abundante fue la cefalea. El hallazgo en exámenes complementarios y electrocardiográficos más frecuente fue la hipertrofia ventricular izquierda, siendo el corazón el órgano diana más afectado

  3. Outcome similarity modulates retroactive interference between cues trained apart

    Directory of Open Access Journals (Sweden)

    Oskar Pineño

    2005-01-01

    Full Text Available La semejanza de las consecuencias modula la interferencia retroactiva entre claves entrenadas separadamente. La interferencia retroactiva entre claves entrenadas separadamente ha sido considerada como un efecto que ocurre debido a que las asociaciones “diana” e interfiriente comparten una consecuencia común. Aunque este punto de vista es consistente con la evidencia en la tradición del aprendizaje verbal (Underwood, 1966 y, más recientemente, en el aprendizaje predictivo con humanos (Pineño y Matute, 2000, se ha llevado a cabo escasa investigación para averiguar si la ocurrencia de este efecto depende críticamente de que las asociaciones “diana” e interfiriente compartan una consecuencia idéntica. El presente experimento estudió, en aprendizaje predictivo con humanos, la interferencia retroactiva entre claves entrenadas separadamente en función de la semejanza de las consecuencias emparejadas con las claves. Se encontró una interferencia más fuerte cuando las claves fueron emparejadas con la misma consecuencia que cuando fueron emparejadas con consecuencias similares o diferentes.

  4. Measurements of Positronium Formation Cross Sections for Positron-Kr, Xe Scattering

    Science.gov (United States)

    Kauppila, W. E.; Kwan, C. K.; Li, H.; Stein, T. S.; Zhou, S.

    1997-04-01

    Our experimental approach(S. Zhou et al., Phys. Rev. Lett. 73, 236 (1994).) for measuring Ps formation cross sections (Q_Ps) involves passing a variable energy positron beam through a gas scattering cell and detecting the 511 keV annihilation gamma rays resulting from the decay of para-Ps and from the interaction of ortho-Ps with the walls of the scattering cell. It is found that the Q_Ps curves for both Kr and Xe rise rapidly from their formation threshold energies of 7.2 and 5.3 eV, reach maxima within about 10 eV of their thresholds and then decrease to become rather small (less than 10% of the peak heights) above 100 eV. At the maxima Q_Ps accounts for more than 50% of the total scattering cross sections. There is some evidence of possible small scale structure in the Q_Ps curves between 10 and 100 eV. The present results are consistent with the prior measurements of Diana et al.( L.M. Diana et al., in "Atomic Physics with Positrons", edited by J.W. Humberston and E.A.G. Armour (Plenum, New York and London, 1987), p. 55; and in "Positron Annihilation", edited by L. Dorikens-Vanpraet et al. (World Scientific, Singapore, 1989), p. 311.) from near threshold to 70 eV for Kr and from 15 to 100 eV for Xe.

  5. The Mythology of the Night Sky An Amateur Astronomer's Guide to the Ancient Greek and Roman Legends

    CERN Document Server

    Falkner, David E

    2011-01-01

    Every amateur astronomer can easily recognize most of the constellations, but how many of us know the story behind them? What myths did the Ancient Greeks weave around the mighty hunter Orion that places him so prominently in the sky? Did you know that this mythical being was said to have been killed by Diana, herself a hunter, while he was exhausted by his fight with Scorpius? The constellation of Scorpius, the giant scorpion, is dominated by the red supergiant Antares and hangs in the sky opposite Orion. Yet there is no constellation of Diana to be found! The Mythology of the Night Sky strikes a balance between backyard astronomy and ancient mythology. Organized by seasons, this book describes Ptolemy's 48 constellations with location and description in detail, while also telling the mythological tales in full. Along with the named constellations, this title also incorporates the lore behind the christening of the planets and their satellites. Readers discover the importance of the ancient characters, why...

  6. Método Avenzoar para la implantación racional de la atención farmacéutica en la farmacia comunitaria

    Directory of Open Access Journals (Sweden)

    Ojeda-Casares M

    2015-06-01

    Full Text Available Introducción: La evolución de la atención farmacéutica en España, el desarrollo de las tecnologías de la información y la comunicación, los proyectos de receta electrónica, la aparición de publicaciones como el Foro de Atención Farmacéutica, el desarrollo del Bot Plus y su integración con los programas de gestión de las farmacias comunitarias nos han permitido definir una metodología de trabajo en atención farmacéutica (AF, estratificada y selectiva. Metodología: 1. Identificar el paciente destinatario del tratamiento. 2. Dispensación propiamente dicha. 3. Definición del perfil farmacoterapéutico de la farmacia. 3.1. Grupos terapéuticos. 3.2. Indicaciones terapéuticas. 4. Definición de patologías diana. 4.1. Relevancia numérica. 4.2. Relevancia terapéutica. 5. Definición del potencial de seguimiento farmacoterapéutico (SFT de la farmacia comunitaria. 6. Elección de pacientes diana. 7. Ofrecimiento del servicio de SFT. Resultados: En las cuatro farmacias comunitarias (FC participantes se definió el perfil farmacoterapéutico a partir de los grupos terapéuticos a nivel 1. A partir de aquí dichas farmacias definieron sus respectivas patologías diana y los posibles pacientes a los que ofrecer el servicio. Se basan en dichos resultados para establecer la formación de sus profesionales. Conclusiones: La metodología Avenzoar parte del conocimiento del paciente mediante el registro sistemático de las dispensaciones realizadas. Permite definir el perfil farmacoterapéutico de los pacientes. Permite decidir el nivel de implicación con el seguimiento de cada paciente según criterios previamente definidos. La metodología Avenzoar es compatible y complementaria con cualquier metodología de seguimiento farmacoterapéutico.

  7. Um atlas contra o vento

    Directory of Open Access Journals (Sweden)

    Raúl Antelo

    2011-06-01

    Full Text Available Este artigo aborda duas exposições, Atlas. Como llevar el mundo a cuestas?, cujo curador foi Georges Didi-Huberman e Imágenes e Historias. Argentina 1848-2010, curada por Diana Wechsler. Am-bas consideram a produção artística como fruto de montagem, em que objetos, espaços e tempos podem ser reconfigurados. Am-bas também encaram a experiência da imagem com base não na ordem cronológica e logocêntrica, como no historicismo clássico, mas a partir do reconhecimento da densidade de sentidos da imagem, bem como de seu poder expressivo, capaz de desestabilizar paradigmas epistemológicos da história da arte.Esta comunicación aborda dos exposiciones, Atlas. Como llevar el mundo a cuestas?, cuyo comisario fue Georges Didi-Huberman e Imágenes e Historias. Argentina 1848-2010, curada por Diana Wechsler. Ambas consideran la producción artística como fruto de montaje, en que objetos, espacios y tiempos pueden ser reconfigurados. Ambas encaran la experiencia de la imagen no en base al orden cronológico y logocéntrico, como en el historicismo clásico, sino basándose en el reconocimiento de la densidad de sentidos de la imagen y asimismo en su poder expresivo, capaz de desestabilizar paradigmas epistemológicos de la historia del arte.This paper focuses two exhibitions, Atlas. How to carry the world on one's back?, curated by Georges Didi-Huberman and Images and histories. Argentina 1848-2010, curated by Diana Wechsler. Both consider artistic production as a montage, in which things, places and time can be reconfigured. Both also approach the experience of images not on the basis of chronological and logocentric order, like in classical historicism, but rather on the basis of a recognition of images' density of meaning and expressive power capable of destabilizing the epistemological patterns of art history.

  8. Phytotoxic Activity of Stem Bark and Leaves of Blepharocalyx salicifolius (Myrtaceae on Weeds

    Directory of Open Access Journals (Sweden)

    Eduardo HABERMANN

    2015-01-01

    En este estudio se evaluó la fitotoxicidad de los extractos y fracciones de las cortezas del tallo (suber y de las hojas maduras de Blepharocalyx salicifolius Kuth O. Berg sobre el crecimiento inicial de Echinochloa crus- galli L. P. Beauv. (capim-arroz y Euphorbia heterophylla L. (amendoim-bravo. Estos extractos fueron obtenidos por extracción exhaustiva y fraccionamiento por coeficiente de partición con disolventes orgánicos. Posteriormente los extractos de acetato de etilo de las hojas y de la corteza del tallo (suber fueron fraccionados por cromatografía de columna con disolventes de polaridad creciente. Tanto los extractos como las fracciones se ensayaron sobre las plantas diana en concentraciones de 0,2, 0,4 y 0,8 mg/mL, como control positivo se utilizó el herbicida comercial Sanson® disuelto en las mismas condiciones y como control negativo agua destilada con DMSO (5uL/mL. Los extractos de acetato de etilo de hojas maduras y corteza así como el extracto de hexano de la corteza mostraron los efectos inhibitorios más pronunciados sobre el crecimiento de las especies diana. De las ocho fracciones del extracto de acetato de etilo de hojas, seis inhibieron el crecimiento de las raíces de capim-arroz y cuatro fracciones inhibieron el crecimiento de las raíces y de la parte aérea de amendoin-bravo en todas las concentraciones ensayadas. De las seis fracciones del extracto de acetato de etilo de corteza, cuatro fueron fitotóxicos sobre el crecimiento de la raíz de capim-arroz en todas las concentraciones. Los extractos y fracciones de la corteza y de las hojas maduras provocaron anomalías en las especies diana. Estos resultados demostraron un efecto fitotóxico pronunciado de los extractos y fracciones de corteza y hojas maduras y su potencial uso como herbicidas naturales.

  9. Calibrating and validating a FE model for long-term behavior of RC beams

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    Tošić Nikola D.

    2014-01-01

    Full Text Available This study presents the research carried out in finding an optimal finite element (FE model for calculating the long-term behavior of reinforced concrete (RC beams. A multi-purpose finite element software DIANA was used. A benchmark test in the form of a simply supported beam loaded in four point bending was selected for model calibration. The result was the choice of 3-node beam elements, a multi-directional fixed crack model with constant stress cut-off, nonlinear tension softening and constant shear retention and a creep and shrinkage model according to CEB-FIP Model Code 1990. The model was then validated on 14 simply supported beams and 6 continuous beams. Good agreement was found with experimental results (within ±15%.

  10. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to “Appl’In® polyphenolic apple extract powder (Malus domestica)” and reduction of post-prandial glycaemic responses pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Diana Naturals pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of France, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to “Appl....... The Panel considers that reduction of post-prandial glycaemic responses (as long as post-prandial insulinaemic responses are not disproportionally increased) may be a beneficial physiological effect. The applicant provided one published and two unpublished human studies, three animal studies and two...... in vitro studies as pertinent to the claim. The Panel notes that the food used in one human study did not comply with the specifications of the food which is the subject of the claim and considers that no conclusion can be drawn from this study for the scientific substantiation of the claim. In two other...

  11. In memoriam 2002

    Index Scriptorium Estoniae

    2003-01-01

    Maailm: Kenneth Armitage (18. VII 1916-22. I), Eduardo Chillida (10. I 1924-19. VIII), Ruth Handler (4. IV 1916-27. IV), Yousuf Karsh (23. XII 1908-14. VII), Roberto Matta (11. XI 1911-23. XI). Eesti: Endel Kaldmäe (12. VII 1918-15. XII), Tiia Kelomees-Johannson (8. IX 1965-11. VI), Salme Kirsimäe (6. XI 1919-1. IV), Maret Kuke (9. X 1926-2. VII), Diana Laev (21. XI 1919-31. VIII), Pauline Leps (16. XI 1903-5. III), Avo-Himm Looveer (16. VIII 1941- 1. V), Jüri Palm (14. IV 1937-27. IV), Agu Pilt (26. VIII 1951-11. III), Valve Pormeister (13. IV 1922-27. X), Eugen Sacharias (21. IV 1906-13. III), Lilian Schönberg (25. IV 1934-10. X), Laine Sisa (12. II 1931-20. II)

  12. Búsqueda de nuevos agentes antiprotozoarios selectivos

    Directory of Open Access Journals (Sweden)

    Vladímir V. Kouznetsov, PhD, DSc* Carlos Mario Meléndez Gómez, Químico**

    2009-04-01

    Full Text Available Se da la información general sobre los fármacos antiprotozoarios que están usándose en clínica, se discuten nuevas dianas de los parásitos protozoarios útiles en la búsqueda de nuevos agentes antiprotozoarios, enfocando la atención al rol biológico de las proteasas de los parásitos protozoarios. Esta información importante será útil para los estudiantes e investigadores que se interesen a los problemas de química medicinal (un área naciente en Colombia cuál aporta mucho al desarrollo de ciencias médicas. [Kouznetsov V, Meléndez C. Búsqueda de nuevos agentes antiprotozoarios selectivos. MedUNAB2009; 12:33-45

  13. Carotenoids and lycopene content in fresh and dried tomato fruits and tomato juice

    Directory of Open Access Journals (Sweden)

    Andrea Mendelová

    2013-01-01

    Full Text Available Important component of the tomato are carotenoid dyes, especially lycopene. The importance of lycopene in the diet of people in recent years has grown mainly for its pharmacological effects due to its ability to reduce the risk of carcinoma diseases and prevention of cardiovascular diseases. The aim of this work was to analyze the content of total carotenoids and lycopene in 8 varieties of tomato and to monitor dynamic changes after their different treatments (heating, drying. The experiment included following tomato varieties: Bambino F1, Darina F1, Diana F1, Denár, Milica F1, Orange F1, Paulína F1, Šejk F1.We found that processing of tomato fruits into juices and dried slices positively affected the presence of carotenoids and lycopene. Processing leads to an increase in the content of carotenoids that can be attributed to better availability of these components in the human body.

  14. G

    OpenAIRE

    2006-01-01

    GALLONE Carmine (1886-1973)Singulière figure de cinéaste qui a traversé l’histoire du cinéma, et pas seulement celle du cinéma italien, pendant plus de cinquante ans, Carmine Gallone a commencé sa carrière dans les années dix en mettant en scène plusieurs films avec Lyda Borelli, Fior di male (1915), La falena, Malombra (1916), Diana Karenne, Redenzione (1919), et surtout sa femme Soava Gallone, une actrice délicate et à l’interprétation très spirituelle. À la fin de la décennie, il partage l...

  15. Transnational Literature, November 2011: Articles, Interviews etc. (complete

    Directory of Open Access Journals (Sweden)

    2011-11-01

    Full Text Available This file includes five articles: Nicholas Birns, 'The Solid Mandala and Patrick White's Late Modernity'; Md Rezaul Haque, 'The Nation and One of its Fragments in Kanthapura'; Diana Jovasiene, 'Herkus Kuncius' Novel The Ornament as a postmodern analaysis of Contemporary Lithuanian Society'; Holly E. Martin, 'Falling into America: The Downside of Transnational Identities in Hi Jin's A Good Fall'; and Umme Salma, 'Woman and the Empire in Alexander Pope's The Rape of the Lock: A Rereading'; one review essay, Dorothy Driver, 'Trauma, Memory and Narrative in South Africa: Interviews'; two interviews with Amy T. Matthews and Altaf Tyrewala; an English translation by Mohammad Quayum of Istrijatir Abanati (Woman's Downfall by Rokeya Sakhawat Hossain; and 'Fiji without Snorkelling: a report from the First Fiji Literary Festival.'

  16. Bridging the Particle Physics and Big Data Worlds

    Science.gov (United States)

    Pivarski, James

    2017-09-01

    For decades, particle physicists have developed custom software because the scale and complexity of our problems were unique. In recent years, however, the ``big data'' industry has begun to tackle similar problems, and has developed some novel solutions. Incorporating scientific Python libraries, Spark, TensorFlow, and machine learning tools into the physics software stack can improve abstraction, reliability, and in some cases performance. Perhaps more importantly, it can free physicists to concentrate on domain-specific problems. Building bridges isn't always easy, however. Physics software and open-source software from industry differ in many incidental ways and a few fundamental ways. I will show work from the DIANA-HEP project to streamline data flow from ROOT to Numpy and Spark, to incorporate ideas of functional programming into histogram aggregation, and to develop real-time, query-style manipulations of particle data.

  17. Genoma de Candida albicans y resistencia a las drogas

    OpenAIRE

    Cruz Quintana, Sandra; Díaz Sjostrom, Pedro; Mazón Baldeón, Gloria; Arias Socarrás, Dunier; Calderón Paz, María; Herrera Molina, Angélica

    2017-01-01

    Resumen Candida albicans es un importante patógeno fúngico en los humanos tanto por su importancia clínica como por su uso como un modelo experimental para la investigación científica. La comprensión de la biología de este patógeno es un requisito importante para la identificación de nuevas dianas de medicamentos para la terapia antifúngica. En esta revisión nos proponemos profundizar en las características del genoma de Candida albicans, su relación con la virulencia y cómo influye en la res...

  18. Genoma de Candida albicans y resistencia a las drogas

    OpenAIRE

    Sandra Cruz Quintana; Pedro Díaz Sjostrom; Gloria Mazón Baldeón; Dunier Arias Socarrás; María Calderón Paz; Angélica Herrera Molina

    2017-01-01

    Candida albicans es un importante patógeno fúngico en los humanos tanto por su importan - cia clínica como por su uso como un modelo experimental para la investigación científica. La comprensión de la biología de este patógeno es un requisito importante para la identificación de nuevas dianas de medicamentos para la terapia antifúngica. En esta revisión nos proponemos profundizar en las características del genoma de Candida albicans, su relación con la virulen - cia y cómo influye en la re...

  19. The public of media events

    Directory of Open Access Journals (Sweden)

    Christian Morgner

    2010-12-01

    Full Text Available This article focuses on the growing importance of large-scale events and their central role in a globalised media world in relation to public reactions and public involvement. The peculiar structure of such events requires a different understanding of mass communication and its audience. Therefore, the audience is further examined with regard to its impact on and inclusion in the media itself. Consequently, questions are raised as to how the public is incorporated, the form this inclusion takes and the effect that this has on the audience’s participation.The article examines different types of semantic inclusion, with a focus on emotional reactions towards three different media events: the Titanic disaster, the assassination of John F. Kennedy, and the death of Princess Diana.

  20. Ex-Votos às Ninfas em Portugal

    OpenAIRE

    Joaquim Rodrigues dos SANTOS JUNIOR; Mario CARDOZO

    2009-01-01

    A expansào na Península Hispánica dos cultos consagrados às divindades do Panteáo romano, revelada em numerosos textos epigráficos dedicados a Júpiter, Diana, Minerva, Juno, Marte, Cerei, etcétera, e bem assim dos cultos de origem oriental que as relaçôes militares, comerciáis e políticas do Imperio com os povos da Asia e de África haviam introduzido em Roma —cultos a Se rapis, I sis, Cibele, Mitra, etc.— nao logrou dissipar, na religiosidade ancestral do íncola do Ocidente, os cultos que, an...

  1. shinyCircos: an R/Shiny application for interactive creation of Circos plot.

    Science.gov (United States)

    Yu, Yiming; Ouyang, Yidan; Yao, Wen

    2018-04-01

    Creation of Circos plot is one of the most efficient approaches to visualize genomic data. However, the installation and use of existing tools to make Circos plot are challenging for users lacking of coding experiences. To address this issue, we developed an R/Shiny application shinyCircos, a graphical user interface for interactive creation of Circos plot. shinyCircos can be easily installed either on computers for personal use or on local or public servers to provide online use to the community. Furthermore, various types of Circos plots could be easily generated and decorated with simple mouse-click. shinyCircos and its manual are freely available at https://github.com/venyao/shinyCircos. shinyCircos is deployed at https://yimingyu.shinyapps.io/shinycircos/ and http://shinycircos.ncpgr.cn/ for online use. diana1983941@mail.hzau.edu.cn or yaowen@henau.edu.cn.

  2. Analysis of Movie I Am Not Stupid 2: Parenting Style 分析《小孩不笨2》电影的父母教育法

    Directory of Open Access Journals (Sweden)

    Mariana Mariana

    2015-04-01

    Full Text Available This paper, through Singaporean movie I am not Stupid 2, analyzes the relation between parenting and children’s growth process and also the action of parents should do to offer children for having a good growth process. Research was done based on Baumrind theory about parenting analysis to what kind of parenting that the parents of the movie I am not Stupid 2 offer to their children. Research used literature study to summarize, arrange, and analyze of Diana Baumrind as basis of the research. The results show that Tom and Jerry’s parents or Cheng Cai’s father used authoritarian parenting style. Research suggests that the best parenting style is authoritative parenting because this type of parenting does not only concern about the prominence of rules or regulations in the family, but also the affection of parents towards the children. Therefore, the family will certainly become more harmonious. 

  3. Ecos de la novela griega en el Renacimiento

    Directory of Open Access Journals (Sweden)

    Lourdes Rojas Alvarez

    2012-09-01

    Full Text Available The Greek novel, a multifaceted fiction genre in prose, flourished between the first and the fourth Century A.D., had its continuation into the Byzantine literature. The significance of the Greek novels reached the Renaissance with Longus and his Daphnis and Chloe, that influenced Sanazzaro's Arcadia in Italy, or Jorge de Montemayor's Diana, in Spain. It also had a certain influence in Cervantes' Galatea and even in his Quijote. Sidney's Arcadia is also tributary to the theme, such as Honoré d' Urfé's Astrea, in France. In this paper I want to point out the influence of the Greek novel in Shakespeare I will focus in The Tempest, comedy in five acts, that reveals great affinity with the Greek novel of love and adventures of Longus, Xenophon of Ephesus and Achilles Tatius, as well as in the utopian novel

  4. VERBALIZACIÓN EN DOS MUJERES OCTOGENARIAS - VERBALIZATION IN TWO OCTOGENARIAN WOMEN

    Directory of Open Access Journals (Sweden)

    JHONNY LOAIZA GARCÍA

    2010-06-01

    Full Text Available This research was developed according to the criteria of the empiric analytic paradigm. It includes a descriptive analysis about the verbal fluency of two people who are more than 80 years old who consider language the basic way to express themselves. The necessary information was got by applying the WAIS verbal test which evaluates language in some specific areas.Besides applying the test, it was also used an interview which showed some important data about each patient’s personal history. The results were analyze according to a clinic optic, supported by the analysis proposed by Josette Benavides (1984 in character evaluation techniques. This research also follows the knowledge contributed by the memory clinic of Universidad Javeriana, directed by Patricia Montañes, Diana Matallana and Carlos Cano, authors of many studies related to the elderly people in Colombia

  5. Vaba Läti ehitab / Margit Mutso

    Index Scriptorium Estoniae

    Mutso, Margit, 1966-

    2007-01-01

    13.-17.04. 2007 hindas rahvusvaheline žürii Läti parimaid arhitektuuriteoseid. Parim rekonstrueeritud ehitis oli büroohoone Riias Dzirnavu tn. 68 (arhitektid Aleksejs Birjukovs, Andis Silis). Parim tööstushoone oli Ventspilsis asuv mahlakontsentraatide käitlus- ja laohoone (arhitektid Aija Kokina, Andris Kokins, Krista Strelita-Strele). Bürookategooria võiduprojektiks valiti Liepajas Zivju tn. 11/13 paiknev kontorihoone (arhitektid Diana Zalane, Artis Rokis). Parima elamu tiitli pälvis Jurmalas Jura tn. 32 asuv maja (arhitektid Janis Alksnis, Nora Saulespurena, Andris Rubenis). Eramajadest oli parim suvemaja Pavilostas (arhitekt Janis Sauka). Parima maastikuarhitektuur-väikevormi preemia said Gvido Rekis, Anita Neilande, Andris Kausenieks, Didzis Oshenieks Ventspilsi dzhungliraja eest. Sisekujunduspreemia sai originaaldisainiga ekspositsioonikapslitega Grindeksi farmaatsiatoodete näidisteruum Riias

  6. All’s [Not] Well: Female Service and ‘Vendible’ Virginity in Shakespeare’s Problem Play

    Directory of Open Access Journals (Sweden)

    Emily C. Gerstell

    2015-03-01

    Full Text Available The article examines the economics of female service in William Shakespeare’s All’s Well That Ends Well, paying particular attention to the role Helena plays as mistress to the Widow Capilet and Diana. Such a focus reveals that what lies at the heart of All’s Well is not only, as previous scholarship has suggested, a battle between the sexes but also an intense focus on class and money. By examining both the ties between women and the ties between men that Helena forges and strengthens, I demonstrate that issues of economics and self-interest govern not only male-female relationships but also those between women. In particular, such attention highlights the role that service – conceived of as both economic and sexual – plays in driving the action and the ‘problem’ of All’s Well.

  7. The marble head of a statuette from Mediana (excavations in 2001

    Directory of Open Access Journals (Sweden)

    Plemić Bojana

    2013-01-01

    Full Text Available During the archaeological excavations in Mediana in 2001, the head of a marble statuette of exceptional beauty and craftsmanship was discovered. It was an isolated discovery, the sculpture probably having been imported from some Greek artistic centre or an eastern Mediterranean workshop, presenting a part of a larger ensemble of sculptures that had adorned an imperial villa with peristyle. Since the head was found in pieces and being just part of a sculptural representation with no reliable attributes, the question of its identification is a difficult task. It was possible to determine, using stylistic traits' analysis that the statuette was made under the influence of Hellenistic cult sculpture, namely that it followed the rules of the school of Praxiteles. On the other hand, the iconographic elements, in particular that of the hairstyle, lead us to the conclusion that this statuette could represent one of two Roman goddesses, either Venus or Diana.

  8. Parametric study on the behaviour of bolted composite connections

    Directory of Open Access Journals (Sweden)

    M. N. Kataoka

    Full Text Available The studied connections are composed of concrete filled steel tubes (CFT connected to composite beams by passing through bolts, endplates and steel deck, which also contributes to support the applied loads. The parametric analysis presented in this work is based on numerical simulations performed with software TNO Diana, using experimental results to calibrate the reference numerical model. The influence of three main parameters, being them the bolts diameter, the slab height and the beams cross section, was evaluated. According to the obtained bending moment versus rotation curves, it was concluded that, among the three parameters analyzed, the most important one was the bolts diameter. About the beams cross section, inconclusive results were achieved, probably due to the incompatibility between the 16 mm bolts and the robust beam cross sections considered in the parametric analysis.

  9. A study on family communication pattern and parenting styles with quality of life in adolescent.

    Science.gov (United States)

    Sanavi, Fariba Shahhraki; Baghbanian, Abdolvahab; Shovey, Mehdi Faraji; Ansari-Moghaddam, Alireza

    2013-11-01

    To investigate the relationship between parenting styles and family communication patterns with adolescent's quality of life. The cross-sectional study was carried out on 439 randomly selected adolescents in the city of Zahedan, Iran, from January to July 2011.The subjects were asked to complete the KIDSCREEN-52 health-related quality of life questionnaire, while their parents were asked to complete the Diana Brinder's Test to show their parenting styles. SPSS 15 was used to analyse data. Most parents had 'authoritative' parenting style (n = 380; 86.6%). Pluralistic (n = 170; 38.7%) and consensual (n = 152; 34.6%) patterns were the most frequent styles of communication in families. Data suggested a significant relationship between parenting style and some dimensions of quality of life, including physical well-being, psychological well-being, social support and peers, and autonomy (p parent relation and home life (p parents while raising their children.

  10. Trade of engravings and books between Rome and Spain at the end of the 16th century: the case of the Italian merchant Antonio Pisano

    Directory of Open Access Journals (Sweden)

    María Josefa Tarifa Castilla

    2017-03-01

    Full Text Available This study reveals the arrival of prints and books to the North of Spain acquired by the Italian merchant Antonio Pisano in Rome during a trip of 1582-1583. The voyage was financed thanks to the temporary commercial company established between Pisano and the Genoese Juan Luis de Musante, royal master-builder to Felipe II in Navarre, and both residents in Pamplona. The works include engravings of sacred and profane themes by the most important engravers of the epoch, such as the Dutch Cornelis Cort and the Mantuans Adamo and Diana Ghisi, in addition to books of figures, some by outstanding artists such as Michelangelo or Polidoro da Caravaggio.

  11. Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature

    Directory of Open Access Journals (Sweden)

    Aldag C

    2016-11-01

    Full Text Available Caroline Aldag,1,* Diana Nogueira Teixeira,1,* Phillip S Leventhal2 1Merz Pharmaceuticals GmbH, Frankfurt am Main, Germany; 24Clinics, Paris, France *These authors contributed equally to this work Abstract: Skin aging is primarily due to alterations in the dermal extracellular matrix, especially a decrease in collagen I content, fragmentation of collagen fibrils, and accumulation of amorphous elastin material, also known as elastosis. Growth factors and cytokines are included in several cosmetic products intended for skin rejuvenation because of their ability to promote collagen synthesis. Matrikines and matrikine-like peptides offer the advantage of growth factor-like activities but better skin penetration due to their much smaller molecular size. In this review, we summarize the commercially available products containing growth factors, cytokines, and matrikines for which there is evidence that they promote skin rejuvenation. Keywords: cosmetics, skin, aging, growth factor, cytokine, matrikine

  12. Autonomy and autonomy competencies: a practical and relational approach.

    Science.gov (United States)

    Atkins, Kim

    2006-10-01

    This essay will address a general philosophical concern about autonomy, namely, that a conception of autonomy focused on freedom of the will alone is inadequate, once we consider the effects of oppressive forms of socialization on individuals' formation of choices. In response to this problem, I will present a brief overview of Diana Meyers's account of autonomy as relational and practical. On this view, autonomy consists in a set of socially acquired practical competencies in self-discovery, self-definition, self-knowledge, and self-direction. This account provides a distinction between choices that express unreflectively internalized social norms and those that are the result of a critical 'self-reading'. I conclude that this practical conception of autonomy makes much higher demands upon nurses (and patients) than has previously been thought. In fact, if nurses are to be expected to genuinely promote autonomy, they are going to need specific training in counselling-type communication skills.

  13. List of reviewers

    Directory of Open Access Journals (Sweden)

    Neven Vrček

    2012-12-01

    Full Text Available József Tar Institute of Intelligent Engineering Systems, BudapestGašper Mušič University of Ljubljana, SloveniaWilliam Steingartner Technical University of Košice, SlovakiaIvana Jugović Institute for Social Research, CroatiaGilda Pecaric University of Zagreb, CroatiaElisabeth Pergler Evolaris next level GmbH, AustriaAlen Lovrenčić University of Zagreb, CroatiaPeter Andreae Victoria University, New ZealandJan Paralic Technical University Kosice, SlovakiaDiana Šimić University of Zagreb, CroatiaNadica Hrgarek MED-EL Medical Electronics, AustriaJadranka Stojanovski Rudjer Boskovic Institute, CroatiaMilan Ambroz Human Resources Professional, SloveniaKatarina Žager University of Zagreb, CroatiaKresimir Fertalj University of Zagreb, Croatia

  14. Numerical and experimental analysis of time-dependent load transfer in reinforced concrete columns

    Directory of Open Access Journals (Sweden)

    L. T. Kataoka

    Full Text Available A study was conducted to assess the influence of the steel reinforcement ratio in concrete columns on their properties of creep and shrinkage. Experimental tests and three-dimensional finite element-based simulations of the experimental curves from plain concrete cylinders and plain concrete columns derived by curve fitting were performed using the ACI 209 model available in DIANA 9.3. Columns with longitudinal reinforcement ratios of 0%, 1.4% and 2.8%, loaded to 30% and 40% of their 7-day compressive strength, were investigated. The results indicated that numerical simulation does not predict experimental data for a long period. However, simulations fitted with experimental curves derived from plain concrete columns presented values close to those of experimental data for 91 days.

  15. Sincronización del ciclo celular en una línea celular modelo para ensayo de gene targeting

    OpenAIRE

    Velázquez Gómez, Miguel

    2014-01-01

    La terapia génica es una campo de la biomedicina que incluye distintas técnicas orientadas a la cura de enfermedades basadas en errores en el genoma, ya sea por ausencia del gen o por pérdida de su función, a través del envío del material genético corrector (RNA, DNA) al interior de células diana, en las cuales se integra y corrige el fallo. La terapia génica puede orientarse al tratamiento de células germinales o somáticas. La modificación genética de células destinadas a generar espermat...

  16. Physician involvement enhances coding accuracy to ensure national standards: an initiative to improve awareness among new junior trainees.

    Science.gov (United States)

    Nallasivan, S; Gillott, T; Kamath, S; Blow, L; Goddard, V

    2011-06-01

    Record Keeping Standards is a development led by the Royal College of Physicians of London (RCP) Health Informatics Unit and funded by the National Health Service (NHS) Connecting for Health. A supplementary report produced by the RCP makes a number of recommendations based on a study held at an acute hospital trust. We audited the medical notes and coding to assess the accuracy, documentation by the junior doctors and also to correlate our findings with the RCP audit. Northern Lincolnshire & Goole Hospitals NHS Foundation Trust has 114,000 'finished consultant episodes' per year. A total of 100 consecutive medical (50) and rheumatology (50) discharges from Diana Princess of Wales Hospital from August-October 2009 were reviewed. The results showed an improvement in coding accuracy (10% errors), comparable to the RCP audit but with 5% documentation errors. Physician involvement needs enhancing to improve the effectiveness and to ensure clinical safety.

  17. The Representation of Fatherhood by the Arab Diaspora in the United States

    Directory of Open Access Journals (Sweden)

    Marta Bosch

    2008-01-01

    Full Text Available This article1 analyzes three debut novels –Alicia Erian’s Towelhead (2005, Laila Halaby’s West of the Jordan (2003, and Diana Abu-Jaber’s Arabian Jazz (1993– in order to explore the representation of fatherhood by the Arab diaspora in the United States. To do so, it will draw on Ralph La Rossa’s notion of “new father”, and on Julie Peteet’s and Daniel Monterescu’s ideas about Arab masculinity. It will then analyze the main father figures in the novels under the light of these concepts. It will finally conclude that the different existing models of Arab fatherhood move from traditionalism to liberalism, and that allows the possibility of “new fatherhoods” to emerge.

  18. De la postveritat a la postètica

    OpenAIRE

    Alsius, Salvador

    2017-01-01

    L'última nit d'agost de 1997, Diana de Gal·les moria després d'haver tingut un accident de cotxe al túnel del pont de l'Alma de París. Entre les circumstàncies que van envoltar aquest succés hi va haver l'actuació dels paparazzis que aquell mateix vespre, com en jornades anteriors, havien assetjat incansablement "la princesa del poble" i el seu acompanyant. En les següents vint-i-quatre hores, els mitjans de comunicació de tot el món, en totes les llengües imaginables, no van parlar d'altra c...

  19. Massive two-loop Bhabha scattering - the factorizable subset

    International Nuclear Information System (INIS)

    Fleischer, J.; Tarasov, O.V.; Werthenbach, A.

    2002-11-01

    The experimental precision that will be reached at the next generation of colliders makes it indispensable to improve theoretical predictions significantly. Bhabha scattering (e + e - → e + e - ) is one of the prime processes calling for a better theoretical precision, in particular for non-zero electron masses. We present a first subset of the full two-loop calculation, namely the factorizable subset. Our calculation is based on DIANA. We reduce tensor integrals to scalar integrals in shifted (increased) dimensions and additional powers of various propagators, so-called dots-on-lines. Recurrence relations remove those dots-on-lines as well as genuine dots-on-lines (originating from mass renormalization) and reduce the dimension of the integrals to the generic d=4-2ε dimensions. The resulting master integrals have to be expanded to O(ε) to ensure proper treatment of all finite terms. (orig.)

  20. Eriptosis: mecanismos moleculares y su implicación en la enfermedad aterotrombótica

    Directory of Open Access Journals (Sweden)

    Fernando Manzur-Jattin

    2016-05-01

    Conclusiones: La eriptosis se caracteriza por la disminución del volumen celular, la vesiculación y la translocación del fosfatidil serina hacia la superficie externa de la membrana plasmática. Las alteraciones en la distribución de los fosfolípidos favorecen los procesos de adhesión celular a la pared vascular, conllevando al deterioro de la microcirculación, lo cual puede ocasionar importantes trastornos a nivel cardiovascular. La comprensión y el esclarecimiento de la eriptosis pueden ser esenciales para la búsqueda de nuevas dianas terapéuticas, encaminadas a ofrecer otras alternativas farmacológicas en el tratamiento de la enfermedad cardiovascular.

  1. Mitmekülgne eesti lastekirjandus [2006. a.] / Jaanika Palm

    Index Scriptorium Estoniae

    Palm, Jaanika, 1973-

    2008-01-01

    Arvustus: Tungal, Leelo. Lätikeelne jäätis ja teisi luuletusi. Tallinn : Tuum, 2006 ; Trull, Ilmar. Musta kassi mumba. Tallinn : Eesti Ekspressi Kirjastus, 2006 ; Wimberg. Põngerjate laulud. Tallinn : Varrak, 2006 ; Muidugi, Eino. Lõbus pere ütleb tere! Tallinn : Koolibri, 2006 ; Nemvalts, Urmas. Väikeste meeste jutud. [Tallinn] : Grenader, 2006 ; Kangro, Maarja, Kangro, Kirke. Puuviljadraakon. Tallinn : Koolibri, 2006 ; Kilkson, Tiina. Pisikese Peetri pikk pühapäev. Tallinn : Koolibri, 2006 ; Pelmas, Elsa. Sussipäkapikk Siisi seiklused. Tallinn : TEA Kirjastus, 2006 ; Sauter, Peeter. Laiskade laste raamat. Tallinn : Huma, 2006 ; Kivirähk, Andrus. Leiutajateküla Lotte. Tallinn : Eesti Joonisfilm, 2006 ; Ulman, Mihkel. Nukkude teater. Tartu : Elmatar, 2006 ; Rannap, Jaan. Roheline kindlus. Tallinn : Tiritamm, 2006 ; Vallik, Aidi. Narkohollo ehk Florose vabastamine. Haapsalu : Lugu-Loo, 2006 ; Leesalu, Diana. Mängult on päriselt. Tallinn : Tänapäev, 2006 ; Laidla, Siiri. Pärnaõietee. Tallinn : Canopus, 2006

  2. Mitmekülgne eesti lastekirjandus [2006. a.] / Jaanika Palm

    Index Scriptorium Estoniae

    Palm, Jaanika, 1973-

    2007-01-01

    Arvustus: Tungal, Leelo. Lätikeelne jäätis ja teisi luuletusi. Tallinn : Tuum, 2006 ; Trull, Ilmar. Musta kassi mumba. Tallinn : Eesti Ekspressi Kirjastus, 2006 ; Wimberg. Põngerjate laulud. Tallinn : Varrak, 2006 ; Muidugi, Eino. Lõbus pere ütleb tere! Tallinn : Koolibri, 2006 ; Nemvalts, Urmas. Väikeste meeste jutud. [Tallinn] : Grenader, 2006 ; Kangro, Maarja, Kangro, Kirke. Puuviljadraakon. Tallinn : Koolibri, 2006 ; Kilkson, Tiina. Pisikese Peetri pikk pühapäev. Tallinn : Koolibri, 2006 ; Pelmas, Elsa. Sussipäkapikk Siisi seiklused. Tallinn : TEA Kirjastus, 2006 ; Sauter, Peeter. Laiskade laste raamat. Tallinn : Huma, 2006 ; Kivirähk, Andrus. Leiutajateküla Lotte. Tallinn : Eesti Joonisfilm, 2006 ; Ulman, Mihkel. Nukkude teater. Tartu : Elmatar, 2006 ; Rannap, Jaan. Roheline kindlus. Tallinn : Tiritamm, 2006 ; Vallik, Aidi. Narkohollo ehk Florose vabastamine. Haapsalu : Lugu-Loo, 2006 ; Leesalu, Diana. Mängult on päriselt. Tallinn : Tänapäev, 2006 ; Laidla, Siiri. Pärnaõietee. Tallinn : Canopus, 2006

  3. Nutritive value evaluated on rats of new cultivars of common beans (Phaseolus vulgaris) released in Chile.

    Science.gov (United States)

    Yañez, E; Zacarias, I; Aguayo, M; Vasquez, M; Guzman, E

    1995-06-01

    Five new cultivars of common beans (Phaseolus vulgaris) recently released were analyzed for their proximate chemical composition and protein biological quality. The crude protein content in these cultivars ranged from 21.9 percent in cultivar Arroz 3 to 26.9 percent in cultivar Tórtola Diana (dry matter basis). Rats fed cultivar Tórtola INIA gained more weight, had a higher protein intake and registered higher PER and NPR than Tórtola corriente. On the other hand, rats consuming cultivars Arroz 3 and Fleetwood had lower weight gain, lower protein intake and lower PER and NPR than cultivar Coscorrón corriente. However, all these cultivars have a relatively good protein value as compared to other plant protein sources.

  4. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: rockansamblite Sõpruse Puiestee, Dirty Diana ja Shotgun Suicide peost 15. veebr. Rock Cafés, folklooripeost Pärnus Rääma Nooruse majas, klubi Woodstocki 5. sünnipäeva tähistamisest 15. ja 16. veebr., Ultima Thule kontserdist 15. veebr. Tartu Rockiklubis, festivalist "Eesti teater Estonias"16.-23. veebr.Rahvusooperis Estonia, kontsertidest "Küünlavalgel" 19.-21. veebr. Tallinna Matkamajas, prantsuse duo 2G Kevadjazzil 2008 15. veebr. Tartus Athena keskuses, Raadio Elmari juubelipeost 22. veebr. Pärnu kuursaalis, rootsi bändi Soilwork ja Path Of No Return kontserdist 20. veebr. Tallinnas Rock Cafés

  5. In Praise of Ambiguity: Musical Subtlety and Merleau-Ponty

    Directory of Open Access Journals (Sweden)

    Tiger C. Roholt

    2013-01-01

    Full Text Available When a jazz, rock, or hip-hop drummer strikes certain notes in each measure slightly late, instead of hearing the degree to which those notes are late, we typically hear the effects of those variations; namely, a groove, the "feel" of a rhythm. Slight variations of pitch function similarly. In this essay, I argue that certain analytic theorists go astray due to their preoccupation with the variations themselves. By invoking Maurice Merleau-Ponty's insights into subtle visual perceptions, and his notion of perceptual indeterminacy, I avoid an account of musical subtlety suggested by Daniel Dennett that is too coarse-grained, as well as the bleak conclusion that certain musical subtleties are ineffable, Diana Raffman's view. I conclude that elements of music that are perceived ambiguously can perform a positive function in such aesthetic experiences: they can mediate or foster emergent qualities; moreover, they must be perceived in this way to do so.

  6. Análise de vigas mistas de aço e concreto pertencentesa pisos de baixa altura em situação de incêndio: ênfase à influência dos modelos constitutivos do concreto

    Directory of Open Access Journals (Sweden)

    F. M. Rocha

    Full Text Available A incorporação do perfil de aço na laje de concreto, como ocorre nos pisos mistos de baixa altura (slim floor, garante revestimento contrafogo ao aço, melhorando o desempenho da viga de aço frente às ações da corrosão e do incêndio. Com a finalidade de avaliar o desempenhotérmico e estrutural desse sistema construtivo foram desenvolvidos modelos numéricos de vigas mistas de aço e concreto parcialmente revestidas com o uso do pacote computacional DIANA. No que diz respeito aos modelos constitutivos dos materiais, não foi possível representaras relações apresentadas no EUROCODE 4 e na ABNT NBR 14323:2013, por incompatibilidade dessas com o DIANA, sendo então adotadosmodelos alternativos. Em seguida, foram construídos modelos numéricos à temperatura ambiente e em temperatura elevada, contemplandoas opções disponíveis e convenientes para as relações constitutivas do aço e do concreto. Também foram avaliados parâmetros como: (a onível de interação entre o aço e concreto, bem como (b a melhor configuração para os parâmetros térmicos do concreto a fim de se obter umaresposta mais realista do comportamento das vigas pertencentes ao sistema slim floor em situação de incêndio.

  7. El Abencerraje: una lección de virtud en los albores del confesionalismo filipino

    Directory of Open Access Journals (Sweden)

    Torres Corominas, Eduardo

    2013-06-01

    Full Text Available Between 1561 and 1565 the three known versions of El Abencerrage —Crónica, Diana and Inventario— were printed. The moral lesson of these works, based on the principles of the humanism, is opposite to the process of confessionalization promoted by the Hispanic Monarchy in those dates. From the reconstruction of those three writing contexts —and knowing the courtesan faction to which the successive adapters of the work belonged: Jiménez de Embún’s servant, Jorge de Montemayor and Antonio de Villegas— this work attempts to prove, from the studies on the Spanish Court, how the first Spanish Moorish novel was, understood as an ideological discourse, a frontal attack against Philip the II’s confessionalism arised from the political opposition.Entre 1561 y 1565, vieron la luz las tres versiones de El Abencerraje hoy conocidas —Crónica, Diana e Inventario— cuya lección moral, basada en los principios del mejor humanismo, contrastaba con el incipiente proceso de confesionalización emprendido por la Monarquía hispana en esas mismas fechas. A partir de la reconstrucción de aquellos tres contextos de escritura —y encuadrando faccionalmente a los sucesivos refundidores de la pieza: el servidor de Jiménez de Embún, Jorge de Montemayor y Antonio de Villegas— el presente trabajo trata de demostrar, desde los estudios sobre la Corte en España, cómo la primera novela morisca de nuestras letras constituyó, en tanto que discurso ideológico, un ataque frontal contra el confesionalismo filipino surgido desde la filas de la oposición política.

  8. Detección de Leishmania spp. en base al gen que codifica la proteína HSP20

    Directory of Open Access Journals (Sweden)

    Ana M Montalvo

    Full Text Available Objetivos. Explorar una nueva diana para el diagnóstico molecular de Leishmania. Materiales y métodos. Se evaluó la utilidad del gen que codifica la proteína de choque térmico de 20kDa (hsp20 para la detección de Leishmania por medio de la reacción en cadena de la polimerasa (PCR.Se normalizó la PCR y se determinaron los parámetros analíticos, así como la validez y seguridad diagnóstica y la concordancia con la PCR-18S. Se evaluó la PCR-hsp20 con ADN obtenido de un grupo de muestras clínicas de distinta procedencia. Resultados. Los parámetros analíticos resultaron adecuados. La sensibilidad obtenida fue de 86% y la especificidad del 100%, la concordancia con el método de referencia resultó buena (κ = 0,731, lo que apoya su posible uso para el diagnóstico. La posibilidad de identificación posterior de la especie mediante secuenciación del producto amplificado le confiere una ventaja adicional. Conclusiones. Se demuestra la utilidad de este gen como una nueva diana para la detección del género Leishmania. Debido a su potencial, se recomienda mejorar la sensibilidad del procedimiento y realizar su evaluación en diversas regiones endémicas.

  9. Literacy, imagination and autonomy in A House for Mr. Biswas = Letramento, autonomia e imaginação em A House for Mr. Biswas

    Directory of Open Access Journals (Sweden)

    Mariana Bolfarine

    2012-01-01

    Full Text Available The present article tackles the concepts of literacy, imagination and autonomy in A House for Mr. Biswas (1961 by V. S. Naipaul. The novel reveals that the spread of the English language and Englishness became inevitable during British Imperialism since one of the instruments for its propagation was the imposition of the colonizer’s set of values. It will be shown that although limited and detached from the learners’ reality depicted in the narrative, the missionary school education engendered the imagination as a driving force upon which the protagonist, Mr. Biswas, relies in order to achieve his dreams of autonomy. Theory is mostly foregrounded on works by David Slater, Boaventura dos Santos and Diana Brydon.O presente artigo versa sobre os conceitos de letramento (literacy, imaginação e autonomia em A House for Mr. Biswas (1961, de V. S. Naipaul. O romance revela que a difusão da língua inglesa e da inglesidade (englishness tornou-se inevitável durante o imperialismo britânico, na medida em que estes eram instrumentos de propagação dos valores do colonizador. Demonstraremos que, apesar de limitada e desvinculada da realidade retratada na obra, era a educação proporcionada pelas escolas de missionários que engendrava a imaginação, força motriz que permite ao protagonista, Sr. Biswas, alcançar o seu desejo de autonomia. O campo teórico é constituído principalmente pelos estudos de David Slater, Boaventura dos Santos e Diana Brydon.

  10. [Central online quality assurance in radiology: an IT solution exemplified by the German Breast Cancer Screening Program].

    Science.gov (United States)

    Czwoydzinski, J; Girnus, R; Sommer, A; Heindel, W; Lenzen, H

    2011-09-01

    Physical-technical quality assurance is one of the essential tasks of the National Reference Centers in the German Breast Cancer Screening Program. For this purpose the mammography units are required to transfer the measured values of the constancy tests on a daily basis and all phantom images created for this purpose on a weekly basis to the reference centers. This is a serious logistical challenge. To meet these requirements, we developed an innovative software tool. By the end of 2005, we had already developed web-based software (MammoControl) allowing the transmission of constancy test results via entry forms. For automatic analysis and transmission of the phantom images, we then introduced an extension (MammoControl DIANA). This was based on Java, Java Web Start, the NetBeans Rich Client Platform, the Pixelmed Java DICOM Toolkit and the ImageJ library. MammoControl DIANA was designed to run locally in the mammography units. This allows automated on-site image analysis. Both results and compressed images can then be transmitted to the reference center. We developed analysis modules for the daily and monthly consistency tests and additionally for a homogeneity test. The software we developed facilitates the immediate availability of measurement results, phantom images, and DICOM header data in all reference centers. This allows both targeted guidance and short response time in the case of errors. We achieved a consistent IT-based evaluation with standardized tools for the entire screening program in Germany. © Georg Thieme Verlag KG Stuttgart · New York.

  11. Central online quality assurance in radiology. An IT solution exemplified by the German Breast Cancer Screening Program; Zentrale Online-Qualitaetssicherung in der Radiologie. Eine IT-Loesung am Beispiel des deutschen Mammografie-Screening-Programms

    Energy Technology Data Exchange (ETDEWEB)

    Czwoydzinski, J.; Girnus, R.; Sommer, A. [Universitaetsklinikum Muenster (Germany). Referenzzentrum Mammographie; Heindel, W.; Lenzen, H. [Universitaetsklinikum Muenster (Germany). Referenzzentrum Mammographie; Universitaetsklinikum Muenster (Germany). Inst. fuer Klinische Radiologie

    2011-09-15

    Purpose: Physical-technical quality assurance is one of the essential tasks of the National Reference Centers in the German Breast Cancer Screening Program. For this purpose the mammography units are required to transfer the measured values of the constancy tests on a daily basis and all phantom images created for this purpose on a weekly basis to the reference centers. This is a serious logistical challenge. To meet these requirements, we developed an innovative software tool. Materials and Methods: By the end of 2005, we had already developed web-based software (MammoControl) allowing the transmission of constancy test results via entry forms. For automatic analysis and transmission of the phantom images, we then introduced an extension (MammoControl DIANA). This was based on Java, Java Web Start, the NetBeans Rich Client Platform, the Pixelmed Java DICOM Toolkit and the ImageJ library. Results: MammoControl DIANA was designed to run locally in the mammography units. This allows automated on-site image analysis. Both results and compressed images can then be transmitted to the reference center. We developed analysis modules for the daily and monthly consistency tests and additionally for a homogeneity test. Conclusion: The software we developed facilitates the immediate availability of measurement results, phantom images, and DICOM header data in all reference centers. This allows both targeted guidance and short response time in the case of errors. We achieved a consistent IT-based evaluation with standardized tools for the entire screening program in Germany. (orig.)

  12. Central online quality assurance in radiology. An IT solution exemplified by the German Breast Cancer Screening Program

    International Nuclear Information System (INIS)

    Czwoydzinski, J.; Girnus, R.; Sommer, A.; Heindel, W.; Lenzen, H.; Universitaetsklinikum Muenster

    2011-01-01

    Purpose: Physical-technical quality assurance is one of the essential tasks of the National Reference Centers in the German Breast Cancer Screening Program. For this purpose the mammography units are required to transfer the measured values of the constancy tests on a daily basis and all phantom images created for this purpose on a weekly basis to the reference centers. This is a serious logistical challenge. To meet these requirements, we developed an innovative software tool. Materials and Methods: By the end of 2005, we had already developed web-based software (MammoControl) allowing the transmission of constancy test results via entry forms. For automatic analysis and transmission of the phantom images, we then introduced an extension (MammoControl DIANA). This was based on Java, Java Web Start, the NetBeans Rich Client Platform, the Pixelmed Java DICOM Toolkit and the ImageJ library. Results: MammoControl DIANA was designed to run locally in the mammography units. This allows automated on-site image analysis. Both results and compressed images can then be transmitted to the reference center. We developed analysis modules for the daily and monthly consistency tests and additionally for a homogeneity test. Conclusion: The software we developed facilitates the immediate availability of measurement results, phantom images, and DICOM header data in all reference centers. This allows both targeted guidance and short response time in the case of errors. We achieved a consistent IT-based evaluation with standardized tools for the entire screening program in Germany. (orig.)

  13. Permanent Habitats in Earth-Sol/Mars-Sol Orbit Positions

    Science.gov (United States)

    Greenspon, J.

    Project Outpost is a manned Earth-Sol/Mars-Sol platform that enables permanent occupation in deep space. In order to develop the program elements for this complex mission, Project Outpost will rely primarily on existing/nearterm technology and hardware for the construction of its components. For the purposes of this study, four mission requirements are considered: 1. Outpost - Man's 1st purpose-produced effort of space engineering, in which astructure is developed/constructed in an environment completely alien to currentpractices for EVA guidelines. 2. Newton - a concept study developed at StarGate Research, for the development ofa modified Hohmann personnel orbital transport operating between Earth andMars. Newton would serve as the primary crew delivery apparatus throughrepeatable transfer scheduling for all Earth-Lpoint-Mars activities. Thispermanent "transit system" would establish the foundations for Solar systemcolonization. 3. Cruis - a concept study developed at StarGate Research, for the development of amodified Hohmann cargo orbital transport operating between Earth and Mars.Cruis would serve as the primary equipment delivery apparatus throughrepeatable transfer scheduling for all Earth-Lpoint-Mars activities. Thispermanent "transit system" would establish the foundations for Solar systemcolonization, and 4. Ares/Diana - a more conventional space platform configuration for Lunar andMars orbit is included as a construction baseline. The operations of these assetsare supported, and used for the support, of the outpost. Outpost would be constructed over a 27-year period of launch opportunities into Earth-Sol or Mars-Sol Lagrange orbit (E-S/M-S L1, 4 or 5). The outpost consists of an operations core with a self-contained power generation ability, a docking and maintenance structure, a Scientific Research complex and a Habitation Section. After achieving initial activation, the core will provide the support and energy required to operate the outpost in a 365

  14. Captación de participantes en el programa experimental de prescripción de estupefacientes en Andalucía (PEPSA The experimental drug prescription program in Andalusia (PEPSA: procedure for recruiting participants

    Directory of Open Access Journals (Sweden)

    Joan Carles March

    2004-06-01

    Full Text Available Esta nota tiene como finalidad describir los pasos seguidos en el proceso de captación de los participantes en el ensayo andaluz de prescripción de heroína intravenosa. El programa experimental de prescripción de estupefacientes en Andalucía (PEPSA compara el tratamiento de heroína respecto a la metadona oral, en la mejoría de la salud física y mental y la integración social. Dada las características de la población diana (usuarios de heroína por vía intravenosa en situación de exclusión social para quienes no han sido efectivos los tratamientos disponibles, se planificó un abordaje específico para acercar dichas personas al estudio. Tras una investigación previa sobre la distribución de la población diana en la ciudad de Granada, se dividió ésta en 3 zonas. Se acudía a los principales centros de reunión (plazas, comedores sociales, dispensarios de metadona y se concretaba una cita con un médico del PEPSA. El trabajo apoyado en iguales ha sido una herramienta fundamental en este proceso de captación, y ha facilitado el acercamiento a la población diana. Asimismo, este trabajo ha permitido entablar contacto con usuarios de drogas que no acceden a los servicios sociosanitarios, por lo que la labor del equipo de captación también ha sido educar en la reducción de daños y ofrecer alternativas sociales y sanitarias más allá del ensayo.In this field note we describe the steps followed in the process of recruiting participants for the experimental drug prescription program in Andalusia (PEPSA. This trial is a comparative, randomized, open study of the difference between intravenous heroin treatment and oral methadone for socially excluded, opiate-dependent patients, in whom other available treatments have been unsuccessful. Because this is a hidden and hard-to-reach population, a specific approach was planned to put as many patients as possible in touch with the program. A previous study of the target population

  15. Síndrome metabólico en familiares de primer grado de pacientes con diabetes mellitus tipo 2 Metabolic syndrome in first degree relatives of patients with diabetes mellitus 2

    Directory of Open Access Journals (Sweden)

    Raúl Orlando Calderín Bouza

    2005-12-01

    Full Text Available Se realizó un estudio descriptivo y transversal de 340 personas divididas en 2 grupos, con y sin antecedentes patológicos familiares de diabetes mellitus tipo 2 (APF de DM2, con el objetivo de detectar si las que presentaban APF de DM2 tenían más hiperinsulinemia, presencia de síndrome metabólico, factores de riesgo cardiovascular asociados y lesión de órganos diana, expresados en hipertrofia del ventrículo izquierdo de los sujetos que no tenían dicho antecedente. Se obtuvo como resultado que la hiperinsulinemia estuvo presente en 96 pacientes con APF de DM2 (56,5 % y una significación de p = 0,001. El síndrome metabólico fue más frecuente en las personas con APF DM2 (90 para un 52,9 % y una significación de p = 0,000. La hipertrigliceridemia fue el marcador por excelencia del síndrome metabólico y el factor de riesgo que con más significación estadística se asoció a los sujetos con APF de DM2 (96: 52,9 % y una significación de p = 0,000. La hipertrofia ventricular izquierda (HVI se asoció como expresión de lesión de órganos diana a los sujetos con APF de DM2 (36: 21,2 % y una significación de p = 0,043. Concluimos que los sujetos con APF de DM2 son más propensos a tener hiperinsulinemia, al síndrome metabólico, a factores de riesgo cardiovascular y a lesión de órgano diana en comparación con los que no tienen dicho antecedente.A cross-sectional descriptive study of 340 persons assigned to two groups, with and without family history of diabetes mellitus type 2 (DM2, was carried out. The objective was to detect whether those persons with family history of DM2 had more hyperinsulemia, metabolic syndrome, associated cardiovascular risk factors and target organ lesions, expressed in left ventricle hypertrophy, than subjects without diabetes family history. The result was that hyperinsulemia was present in 96 patients with family history of DM2 (56,5 % and significance level of p= 0,001. Metabolic syndrome was more

  16. 驯鹿的皮蝇蛆线粒体CO1基因序列分析%Sequence analysis of mitochondrial cytochrome oxidase 1 (CO1) gene of warble fly larvae from reindeer

    Institute of Scientific and Technical Information of China (English)

    高慧; 杨晓野; 李云章; 莫内; 阿拉腾保力格; 赵治国; 王瑞

    2011-01-01

    The specificity of mitochondrial cytochrome oxidaae 1 ( CO1) gene sequence of warble fly larvae of unknown species from reindeer in Inner Mongolia region of China were analyzed by molecular biological techniques. The results showed that the size of CO1 gene fragment from UEA7 to UEA10 was approximately 689 bp. The analysis of phylogenic tree showed that the unknown species from the reindeer in Inner Mongolia had high homology with Hypoderma diana France isolate. The differences analysis between the different fly species showed:the sequences between Hypodermatidae and Oestridae were obviously different, ranged from 19. 3% to 25. 5% . The divergences of different fly larvae in deer ranged from 1. 9% to 25. 5% . The divergences of Hypoderma. ranged from 6. 7% to 18. 7%. The divergences of Cephenemyia. ranged from 1. 9% to 9. 6% and the variation of the different Hypoderma diana strains was 6. 0%. It suggested that the nucleotide sequences of the mitochondrial CO1 genes could indicate the phylogenetic relationships among different genera, species and strains to some extent.%利用分子生物学技术对内蒙古驯鹿未定种皮蝇蛆线粒体CO1基因种属特异性序列进行了研究.DNA核苷酸测序结果证实:该种皮蝇线粒体CO1种属特异性基因UEA7到UEA10特殊目标编码区域片段长度约为689 bp;种系发生进化树和同源性分析显示其与鹿皮蝇法国株同源性非常接近,因此确定内蒙古地区感染驯鹿的皮蝇蛆为鹿皮蝇(Hypoderma diana).不同蝇种间差异性分析显示:皮蝇科(Hypodermatidae)与狂蝇科(Oestridae)之间序列差异明显,差异性为19.3%~25.5%;寄生于鹿的不同蝇蛆种间差异性为1.9%~25.5%;皮蝇属(Hypoderma)不同种间差异性为6.7%~18.7%;鹿蝇属(Cephenemyia)不同种间差异性为1.9%~9.6%;而同种不同株的鹿皮蝇差异性为6.0%;说明生物线粒体CO1基因核苷酸序列在一定程度上可反映出种属及株间在进化上的差异性.

  17. Biomoléculas interactivas a escala humana

    Directory of Open Access Journals (Sweden)

    José C. Diez

    2013-11-01

    Full Text Available En el proyecto “MolecularPlayground @ UAH.es” se ha instalado una exposición que muestra modelos de diferentes estructuras moleculares de forma programada, en un espacio de acceso común dentro de una facultad. Los estudiantes –y visitantes– pueden controlar la rotación del modelo proyectado moviéndose frente a la pantalla o moviendo sus manos, lo que proporciona interactividad y permite, en cierta medida, la manipulación de la imagen para el análisis e investigación de la estructura. Por ejemplo, el control de la molécula permite analizar los sitios de interacción con receptores u otras dianas, o considerar las fuerzas que definen las interacciones intermoleculares. Cada modelo se presenta de acuerdo a un guión, con diferentes vistas y estilos de representación de la molécula, combinados con breves textos explicativos de su relevancia y enfocando los aspectos notables de la estructura. Los objetivos pueden resumirse en: - Atraer la atención de los alumnos, la comunidad universitaria y el público en general hacia la estructura de las moléculas y su aplicación en campos de interés general: salud, industria, materiales... - Promover, especialmente en los alumnos, el interés por la investigación y la exploración personales. - Promover el análisis de las estructuras de interés bioquímico y farmacológico en la interacción con sus dianas. - Complementar la docencia y el estudio de las ciencias moleculares con materiales multimedia, de comprensión más rápida y eficaz. Proporcionar a los profesores un formato y un medio de difusión de material relacionado con sus asignaturas. Proporcionar a los alumnos material y actividades para el trabajo no presencial.   El proyecto se ha instalado con financiación de la Universidad de Alcalá, proyecto de innovación docente UAH/EV493.

  18. Cómo elaborar Guías de Recomendaciones de Autocuidado para Pacientes y Cuidadores (GRAPyC

    Directory of Open Access Journals (Sweden)

    Sandra Milena Hernández Zambrano

    2015-12-01

    Full Text Available Objetivo: Obtener una estructura estandarizada para la elaboración y publicación de Guías de Recomendaciones de Autocuidado para Pacientes y Cuidadores siguiendo la metodología de la Investigación Acción Participativa. Metodología: La guía se elabora a partir de tres etapas: Emergencia, Interacción y Modelización. En la emergencia, se identifica y analiza el problema principal que afecta a la población diana, se conforma el equipo elaborador, y se realiza una búsqueda de literatura científica que dé respuesta al problema. En la interacción, se establece un diálogo de saberes entre profesionales y ciudadanos para analizar y seleccionar aquellas recomendaciones que se consideran prioritarias para la población diana; se adaptan al nivel de comprensión y entorno cultural de pacientes o cuidadores y se implementan con el objetivo de evaluar su efectividad. Finalmente, en la modelización, se elabora el documento final, considerando tres elementos: diseño de la guía, contenidos y estructura. Estructura de la guía de recomendaciones: El formato establecido consta de 7 apartados: presentación del documento, información general del problema objeto de la guía, recomendaciones por temáticas, recursos web para pacientes y cuidadores, autores e instituciones que participaron en la elaboración y bibliografía. Utilidad esperada: La información contenida en estas guías se ajustada al lenguaje de los ciudadanos, es rigurosa pero fácil de comprender y favorece la toma de decisiones a partir de las mejores evidencias disponibles. Para las enfermeras clínicas se convierte en un instrumento novedoso orientado al diseño de materiales educativos basados en la evidencia científica.

  19. Genoma de Candida albicans y resistencia a las drogas

    Directory of Open Access Journals (Sweden)

    Sandra Cruz Quintana

    2017-01-01

    Full Text Available Candida albicans es un importante patógeno fúngico en los humanos tanto por su importan - cia clínica como por su uso como un modelo experimental para la investigación científica. La comprensión de la biología de este patógeno es un requisito importante para la identificación de nuevas dianas de medicamentos para la terapia antifúngica. En esta revisión nos proponemos profundizar en las características del genoma de Candida albicans, su relación con la virulen - cia y cómo influye en la resistencia a las drogas antifùngicas, que nos permita comprender los mecanismos por los cuales ejerce su acción patógena y desarrollar otros enfoques en la búsqueda de nuevos antifúngicos. La revisión se realizó a través de los buscadores y plataformas HINARI , SciELO y MEDLINE . Se revisaron 40 revistas de impacto de la Web of Science relacionadas con el tema. Los descriptores empleados fueron: “genome of Candida albicans”, “drug resistance genes”, “dimorphism”, “virulence” y la combinación entre ellos y sus equivalentes en español. El análisis de los genomas fúngicos hace posible predecir el rol de genes con potencial terapéu - tico, con la secuenciación del genoma de Candida albicans ha aumentado la información sobre la función de los genes, entre los que destacan los posibles objetivos farmacológicos. El estudio del genoma de Candida albicans resulta imprescindible para diseñar en el futuro protocolos diagnósticos seguros, así como hallar nuevas dianas antifúngicas que permitan formular te - rapias más efectivas.

  20. "Batallas contra la Lepra: Estado, Medicina y Ciencia en Colombia"

    Directory of Open Access Journals (Sweden)

    Carlos Lleras de la Fuente

    2003-03-01

    Full Text Available

    Hace pocos meses tuve el gusto de conocer a Diana Obregón Torres, de quien ya había oído hablar con ocasión de haber ella ganado el premio de Ciencias Sociales y Humanas de la Fundación
    Alejandro Ángel Escobar y de un reportaje que una amiga de mi hija le había hecho.
    Se me presentó en algún evento al cual ambos habíamos concurrido y tuve de ella una primera impresión equivocada: la de una persona suave, estudíosa, de bajo perfíl. Es este tipo de errores que
    lleva a que se desbaraten tantos matrimonios.
    La verdadera Diana es una investigadora rigurosa, erudita, disciplinada, que emite sus opiniones sobre todo y todos sin recato alguno y con una dureza que en muchos casos resulta urticante.
    Esa figura surgió del magnífico libro que el Fondo Editorial Universitario Eafit y el Banco de la República editaron en julio de este año, y cuyas 378 págínas de texto apasionante leí en un par de días, sin contar el vistazo que dí a las 37 páginas de la bibliografía las cuales, además y en notas de pie de página, respaldan la seriedad de su investigación.
    La lectura del líbro es, para un devorad'or de novelas de espionaje, de terror y policiacas, una triple ración de ese suspenso que, ya cerca del amanecer, no nos deja parar. Todos los elementos están en él
    presentes: el criminal es la lepra, que nos transporta al antíguo y al nuevo testamento; ha estado causando terror por varios milenios y nadie ha podido encarcelarla ni, por supuesto, aplicarle la tan desacreditada pena de muerte.
    Hoy día sigue tan campante y de vez en cuando se hace sentír desafíando las sulfonas y el aceite de chaulmugra. Es una enfermedad infecciosa, sin duda, pero el bacilo llamado "de Hansen" se ha defendido con éxito de los bacteriólogos quienes no han logrado producir la vacuna que permitiría erradicar este mal de la faz de la tierra...

  1. Texto e têxtil em O Livro de Travesseiro

    Directory of Open Access Journals (Sweden)

    Andrei Cunha

    2015-12-01

    Full Text Available ABSTRACT: This text is a three-part reflection upon the theme of “clothing” as it is found in a literary work of Ancient Japan — on the importance of garment-making skills as a device for the production of difference in the context of the Imperial Court; on how the theme from the book resonates in the context of 20th century fashion; and on how it is brought up to date and amplified, working as a metaphor for writing, in the film adaptation of the ancient text. In The Pillow Book of Sei Shônagon (Japan, 10th–11th centuries, text, textile and memory merge into an extended, web-like metaphor that is also a commentary on the status of women in Imperial Heian. The adaptation of the written work for the cinema (The Pillow Book, by Peter Greenaway, 1996 features clothes by deconstructivist Martin Margiela, adding new interpretative layers to this cluster of images, relating them to the acts of writing, weaving, reading, translating, adapting and deconstructing. The fragmentary character of Sei Shônagon’s work also resonates with fashion journalism of the 20th century. The aesthetic ideal of okashi, a concept from classical Japanese literature, resonates with 20th century conceptions of fashion, such as Diana Vreeland’s pizzazz, and with the aesthetics of modernist poetry. Clothing as a metaphor for text and the idea of clothing as text are present in those three interpretative moments.

  2. El “Estudio del Rechazo”: mujeres a las que no se les permite abortar

    Directory of Open Access Journals (Sweden)

    The Turnaway Study

    2013-06-01

    Full Text Available Este artículo reseña la investigación que realizó un grupo de investigadoras de ANSIRH (Adelantando Nuevos Estándares en Investigación en Salud de la Universidad de California en San Francisco (UCSF. Este estudio fue aprobado por el Comité de Investigación Humanas de UCSF y fue financiado por la Fundación David and Lucille Packard, por la Fundación Wallace Alexander Gerbode y otros donantes privados. Biografía del Autor The Turnaway Study, Universidad de California en San Francisco El Turnaway Study fue realizado por la Dra. Diana Greene Foster, Ph. D., Investigadora Principal, y la Directora del Proyecto Rana Barar, con la colaboración, entre otras personas, de Tracy Weitz, PhD, MPA, y Heather Gould, MPH, Coordinadora de Investigaciones, y Elisette Weisz, Coordinadora el Proyecto. Traducción por: Gabriela Castellanos

  3. Rifaximin in the treatment of hepatic encephalopathy

    Directory of Open Access Journals (Sweden)

    Iadevaia MD

    2011-12-01

    Full Text Available Maddalena Diana Iadevaia, Anna Del Prete, Claudia Cesaro, Laura Gaeta, Claudio Zulli, Carmelina LoguercioDepartment of Internistica Clinica e Sperimentale, F Magrassi e A Lanzara, Hepatogastroenterology Unit, Second University of Naples, Naples, ItalyAbstract: Hepatic encephalopathy is a challenging complication in patients with advanced liver disease. It can be defined as a neuropsychiatric syndrome caused by portosystemic venous shunting, ranging from minimal to overt hepatic encephalopathy or coma. Its pathophysiology is still unclear, although increased levels of ammonia play a key role. Diagnosis of hepatic encephalopathy is currently based on specific tests evaluating the neuropsychiatric state of patients and their quality of life; the severity of hepatic encephalopathy is measured by the West Haven criteria. Treatment of hepatic encephalopathy consists of pharmacological and corrective measures, as well as nutritional interventions. Rifaximin received approval for the treatment of hepatic encephalopathy in 2010 because of its few side effects and pharmacological benefits. The aim of this work is to review the use and efficacy of rifaximin both in acute and long-term management of hepatic encephalopathy. Treatment of overt hepatic encephalopathy involves management of the acute episode as well as maintenance of remission in those patients who have previously experienced an episode, in order to improve their quality of life. The positive effect of rifaximin in reducing health care costs is also discussed.Keywords: acute hepatic encephalopathy, recurrent hepatic encephalopathy, rifaximin, lactulose, cost, health-related quality of life

  4. To Boldly Go: America's Next Era in Space. Sustaining Life on the Earth

    Science.gov (United States)

    2004-01-01

    Dr. France Cordova, NASA's Chief Scientist, opened this, the sixth seminar in the Administrator's Seminar Series, by introducing NASA Administrator Daniel S. Goldin. Mr Goldin welcomed the attendees and set the stage for Dr. Cordova's introduction of the first speaker, Dr. Robert Kates of Brown University. Dr. Kates primary concerns are global environmental changes, world hunger, and the size of the population. Human changes, he said, rival the changes of nature. Changes in the size of world population affect the need for more agricultural products, therefore more land for growing food, which leads to deforestation, which affects rainfall, and therefore the water supply which is in increased demand. Human ingenuity can reduce some shortages but generally doesn't keep up with increased demand for life-sustaining essentials. These problems require the concern of intergovernmental organizations, treaties and activities, as well as transnational corporations, and non-governmental and private, volunteer organizations. Next Dr. Diana Liverman of Pennsylvania State University spoke on human interactions regarding climate and society. She considered the effect of changes in land use on climate, using Mexico as an example. Mexicans changed from raising much wheat to raising more fruits and vegetables. This was in response to the demands of the market. The results were more industry, population growth, greater income, drought (because the new crops required more water), and conflicts over water supplies. Dr. Charles Kennel of the Office of Mission to Planet Earth joined Dr.s Cordova, Kates, and Liverman for the question and answer session that followed.

  5. Cultura e leitura: Homo zappiens, um leitor ubíquo

    Directory of Open Access Journals (Sweden)

    Miguel Rettenmaier

    2017-07-01

    Full Text Available Das transformações que ocorreram da cultura à cibercultura nasce um novo homem, o Homo zappiens. Neste estudo, uma pesquisa exploratória, bibliográfica e qualitativa, pretende-se compreender como a tecnologia influenciou a cultura do jovem do século XXI a partir de uma narrativa transmídia, partindo de um estudo sobre a cultura em Roger Chartier (1988; 1995 e Lucia Santaella (2003, do perfil do jovem leitor e das gerações jovens com base em  Diana Oblinger e James Oblinger (2005 e Wim Veen e Ben Vrakking (2009, e dos tipos de leitor de Lucia Santaella (2004, para apresentar e analisar a franquia Assassin’s Creed. Neste estudo foi possível perceber que essas aventuras transmidiáticas são potenciais formadoras de novos leitores que buscam encontrar no universo tecnológico as aventuras que ele próprio, leitor das tecnologias e das palavras, quer imaginar e criar, contribuindo para o desenvolvimento e transformação da cultura que vive.

  6. ERP correlates of source memory: unitized source information increases familiarity-based retrieval.

    Science.gov (United States)

    Diana, Rachel A; Van den Boom, Wijnand; Yonelinas, Andrew P; Ranganath, Charan

    2011-01-07

    Source memory tests typically require subjects to make decisions about the context in which an item was encoded and are thought to depend on recollection of details from the study episode. Although it is generally believed that familiarity does not contribute to source memory, recent behavioral studies have suggested that familiarity may also support source recognition when item and source information are integrated, or "unitized," during study (Diana, Yonelinas, and Ranganath, 2008). However, an alternative explanation of these behavioral findings is that unitization affects the manner in which recollection contributes to performance, rather than increasing familiarity-based source memory. To discriminate between these possibilities, we conducted an event-related potential (ERP) study testing the hypothesis that unitization increases the contribution of familiarity to source recognition. Participants studied associations between words and background colors using tasks that either encouraged or discouraged unitization. ERPs were recorded during a source memory test for background color. The results revealed two distinct neural correlates of source recognition: a frontally distributed positivity that was associated with familiarity-based source memory in the high-unitization condition only and a parietally distributed positivity that was associated with recollection-based source memory in both the high- and low-unitization conditions. The ERP and behavioral findings provide converging evidence for the idea that familiarity can contribute to source recognition, particularly when source information is encoded as an item detail. Copyright © 2010 Elsevier B.V. All rights reserved.

  7. Noisy data and distribution maps: the example of Phylan semicostatus Mulsant and Rey, 1854 (Coleoptera, Tenebrionidae from Serra de Tramuntana (Mallorca, Western Mediterranean

    Directory of Open Access Journals (Sweden)

    Palmer, M.

    2003-12-01

    áficos. Pero el éxito en las predicciones de distribución espacial es limitado cuando se dispone de datos imprecisos de la presencia/ausencia. Tanto falsas ausencias como falsas presencias pueden estar relacionadas con desviaciones locales del equilibrio (por ejemplo, extinciones temporales o colonizaciones no exitosas. Además, las falsas ausencias pueden surgir de un esfuerzo de muestreo limitado. Aquí se explora una estrategia analítica para obtener información adicional sobre el patron de presencia/ausencia de una especie diana a partir de la presencia/ausencia de otras especies en la comunidad. La logica es simple: la especie diana debería tener una mayor probabilidad de presencia en un punto si una muestra de este punto es faunísticamente muy similar a las muestras de otros puntos donde la especie ha sido detectada. Por tanto, primeros se modela la presencia/ausencia de la especie diana en función de la similaridad faunística entre puntos. En segundo lugar, los datos observados para la especie diana son reajustados en función de la probabilidad esperada de presencia: las presencias observadas en puntos con probabilidad de presencia muy baja son interpretadas como presencias inestables, y recodificadas como ausencias. De manera similar, las ausencias en puntos con probabilidad de presencia muy elevada son interpretadas como falsas ausencias, y recodificadas como presencias. En el caso experimental estudiado, el procedimiento de recodificación esta basado en los datos de presencia/ausencia de 174 especies, abarcando un abanico taxonómico muy amplio (caracoles terrestres, coleópteros, arañas e isópodos. El mapa de distribución de celdas de 1 km2 del coleóptero endémico Phylan semicostatus es modelado a partir de estos datos. El mapa de distribución es elaborado a partir de cuatro variables medioambientales, usando una estrategia analítica basada en algoritmos genéticos (GARP. Los mapas obtenidos con los datos recodificados parecen ser

  8. Differential miRNA expression in B cells is associated with inter-individual differences in humoral immune response to measles vaccination.

    Science.gov (United States)

    Haralambieva, Iana H; Kennedy, Richard B; Simon, Whitney L; Goergen, Krista M; Grill, Diane E; Ovsyannikova, Inna G; Poland, Gregory A

    2018-01-01

    MicroRNAs are important mediators of post-transcriptional regulation of gene expression through RNA degradation and translational repression, and are emerging biomarkers of immune system activation/response after vaccination. We performed Next Generation Sequencing (mRNA-Seq) of intracellular miRNAs in measles virus-stimulated B and CD4+ T cells from high and low antibody responders to measles vaccine. Negative binomial generalized estimating equation (GEE) models were used for miRNA assessment and the DIANA tool was used for gene/target prediction and pathway enrichment analysis. We identified a set of B cell-specific miRNAs (e.g., miR-151a-5p, miR-223, miR-29, miR-15a-5p, miR-199a-3p, miR-103a, and miR-15a/16 cluster) and biological processes/pathways, including regulation of adherens junction proteins, Fc-receptor signaling pathway, phosphatidylinositol-mediated signaling pathway, growth factor signaling pathway/pathways, transcriptional regulation, apoptosis and virus-related processes, significantly associated with neutralizing antibody titers after measles vaccination. No CD4+ T cell-specific miRNA expression differences between high and low antibody responders were found. Our study demonstrates that miRNA expression directly or indirectly influences humoral immunity to measles vaccination and suggests that B cell-specific miRNAs may serve as useful predictive biomarkers of vaccine humoral immune response.

  9. La divulgación radiofónica de la alimentación y la higiene infantil en la España de la Segunda República (1933-1935

    Directory of Open Access Journals (Sweden)

    Josep Bernabeu Mestre

    2011-01-01

    Full Text Available El trabajo analiza la incorporación de medios tecnológicos, en particular la radio, en el proceso de divulgación del conocimiento sobre la salud infantil durante la Segunda República española. En el marco de la campaña sanitaria contra la mortalidad infantil que puso en marcha la Segunda República en la década del 30, la Asociación Española de Médicos Puericultores Titulados, en colaboración con Unión Radio, organizó dos ciclos de conferencias radiofónicas que pretendían explicar, a través de un discurso divulgativo de tono descriptivo dirigido a las clases populares, las nociones fundamentales de la higiene y la alimentación infantil, e impulsar una cultura de la prevención, guiada y orientada por los dictados de los expertos. Se trataba de una acción de propaganda y divulgación que tenía su continuidad en el medio familiar y comunitario a través de la actuación de las enfermeras visitadoras puericultoras, contemplando a las madres como población diana.

  10. Keragaman Genetik Sekuen Gen ATP Synthase FO Subunit 6 (ATP6 Monyet Hantu (Tarsius Indonesia (GENETIC DIVERSITY STUDY OF ATP6 GENE SEQUENCES OF TARSIERS FROM INDONESIA

    Directory of Open Access Journals (Sweden)

    Rini Widayanti

    2013-07-01

    Full Text Available In a conservation effort, the identification of Tarsier species, on the bases of the morphological andmolecular characteristic is necessary. Up to now, the identification of the animals were based on themorphology and vocalizations, which is extremely difficult to identify each, tarsier species. The objective ofthis research was to study the genetic diversity on ATP6 gene of Tarsius sp. Based on sequencing of PCRproduct using primer ATP6F and ATP6R with 681 nts. PCR product. The sequence of ATP6 fragmentswere aligned with other primates from Gene bank with aid of software Clustal W, and were analyzed usingMEGA program version 4.0. Three different nucleotide sites were found (nucleotide no. 288, 321 and 367.The genetic distance based on nucleotide ATP6 sequence calculated using Kimura 2-parameter modelindicated that the smallest genetic distance 0%, biggest 0.8% and average 0, 2%. The phylogenetic treeusing neighbor joining method based on the sequence of nucleotide ATP6 gene could not be used todifferentiate among T. Dianae (from Central Sulawesi, T. Spectrum (from North Sulawesi, T. bancanus(from lampung, South Sumatera and T.bancanus from West Kalimantan.

  11. Effect of Large Negative Phase of Blast Loading on Structural Response of RC Elements

    Directory of Open Access Journals (Sweden)

    Syed Zubair Iman

    2016-01-01

    Full Text Available Structural response of reinforced concrete (RC elements for analysis and design are often obtained using the positive phase of the blast pressure curve disregarding the negative phase assuming insignificant contribution from the negative phase of the loading. Although, some insight on the effect of negative phase of blast pressure based on elastic single-degree-of-freedom (SDOF analysis was presented before, the influence of negative phase on different types of resistance functions of SDOF models and on realistic finite element analysis has not been explored. In this study, the effects of inclusion of pulse negative phase on structural response of RC elements from SDOF analysis and from more detailed finite element analysis have been investigated. Investigation of SDOF part has been conducted using MATLAB code that utilizes non-linear resistance functions of SDOF model. Detailed numerical investigation using finite element code DIANA was conducted on the significance of the negative phase on structural response. In the FE model, different support stiffness was used to explore the effect of support stiffness on the structural response due to blast negative phase. Results from SDOF and FE analyses present specific situations where the effect of large negative phase was found to be significant on the structural response of RC elements.

  12. The Robber Bride: a Dystopian Female World in Margaret Atwood’s Mythology

    Directory of Open Access Journals (Sweden)

    Maja Ćuk

    2015-06-01

    Full Text Available The aim of this paper is to show how Atwood’s reformulations of myths contain hidden political messages from ancient and modern history and can be interpreted from Fredric Jameson’s views on ‘symbolic acts,’ discourse and the ideology of form. Several scholars have explored the symbolic relationship between the three major protagonists in The Robber Bride and fragments of the omnipotent image of the Neolithic deity the White Goddess. As the symbolic counterparts of Diana, Venus and Hecate in the novel, Tony, Roz and Charis demonstrate how women’s integrity has been crippled and how the restoration of female principle is just a utopian idea. However, our analysis has revealed that the younger generation of “goddesses” does not bring hope to the female gender in either the present or the future. Augusta, Paula and Erin symbolize oversimplified and parodied versions of the destructive Hecate in an unpromising world and “the not-good place” that resembles a dystopia. Keywords: Margaret Atwood, The Robber Bride, the White Goddess, a dystopian world, Hecate, Fredric Jameson

  13. Venus - 3D Perspective View of Latona Corona and Dali Chasma

    Science.gov (United States)

    1992-01-01

    This computer-generated perspective view of Latona Corona and Dali Chasma on Venus shows Magellan radar data superimposed on topography. The view is from the northeast and vertical exaggeration is 10 times. Exaggeration of relief is a common tool scientists use to detect relationships between structure (i.e. faults and fractures) and topography. Latona Corona, a circular feature approximately 1,000 kilometers (620 miles) in diameter whose eastern half is shown at the left of the image, has a relatively smooth, radar-bright raised rim. Bright lines or fractures within the corona appear to radiate away from its center toward the rim. The rest of the bright fractures in the area are associated with the relatively deep (approximately 3 kilometers or 1.9 miles) troughs of Dali Chasma. The Dali and Diana Chasma system consist of deep troughs that extend for 7,400 kilometers (4,588 miles) and are very distinct features on Venus. Those chasma connect the Ovda and Thetis highlands with the large volcanoes at Atla Regio and thus are considered to be the 'Scorpion Tail' of Aphrodite Terra. The broad, curving scarp resembles some of Earth's subduction zones where crustal plates are pushed over each other. The radar-bright surface at the highest elevation along the scarp is similar to surfaces in other elevated regions where some metallic mineral such as pyrite (fool's gold) may occur on the surface.

  14. Assessment of damage localization based on spatial filters using numerical crack propagation models

    International Nuclear Information System (INIS)

    Deraemaeker, Arnaud

    2011-01-01

    This paper is concerned with vibration based structural health monitoring with a focus on non-model based damage localization. The type of damage investigated is cracking of concrete structures due to the loss of prestress. In previous works, an automated method based on spatial filtering techniques applied to large dynamic strain sensor networks has been proposed and tested using data from numerical simulations. In the simulations, simplified representations of cracks (such as a reduced Young's modulus) have been used. While this gives the general trend for global properties such as eigen frequencies, the change of more local features, such as strains, is not adequately represented. Instead, crack propagation models should be used. In this study, a first attempt is made in this direction for concrete structures (quasi brittle material with softening laws) using crack-band models implemented in the commercial software DIANA. The strategy consists in performing a non-linear computation which leads to cracking of the concrete, followed by a dynamic analysis. The dynamic response is then used as the input to the previously designed damage localization system in order to assess its performances. The approach is illustrated on a simply supported beam modeled with 2D plane stress elements.

  15. Management of neovascular age-related macular degeneration: current state-of-the-art care for optimizing visual outcomes and therapies in development

    Directory of Open Access Journals (Sweden)

    Agarwal A

    2015-06-01

    Full Text Available Aniruddha Agarwal, William R Rhoades, Mostafa Hanout, Mohamed Kamel Soliman, Salman Sarwar, Mohammad Ali Sadiq, Yasir Jamal Sepah, Diana V Do, Quan Dong Nguyen Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA Abstract: Contemporary management of neovascular age-related macular degeneration (AMD has evolved significantly over the last few years. The goal of treatment is shifting from merely salvaging vision to maintaining a high quality of life. There have been significant breakthroughs in the identification of viable drug targets and gene therapies. Imaging tools with near-histological precision have enhanced our knowledge about pathophysiological mechanisms that play a role in vision loss due to AMD. Visual, social, and vocational rehabilitation are all important treatment goals. In this review, evidence from landmark clinical trials is summarized to elucidate the optimum modern-day management of neovascular AMD. Therapeutic strategies currently under development, such as gene therapy and personalized medicine, are also described. Keywords: AMD, neovascular AMD, choroidal neovascular membrane, pharmacogenomics, VEGF, low-vision rehabilitation, gene therapy

  16. ANÁLISIS NO LINEAL DE MURETES ARMADOS ENSAYADOS A COMPRESIÓN DIAGONAL

    Directory of Open Access Journals (Sweden)

    Jorge Gonzalo Rosas Rodríguez

    2005-01-01

    Full Text Available El presente trabajo de investigación se propone como objetivo principal estudiar, mediante un análisis no lineal, el comportamiento real de los materiales (unidades, mortero y acero en muretes armados, utilizando como herramienta para el análisis dos técnicas de modelación, micro y macromodelización, desarrolladas especialmente para la mampostería, basadas en el Método de los Elementos Finitos. Para ello se ha realizado la validación de las dos técnicas del Programa computacional DIANA con ensayos realizados en muretes armados de bloques de hormigón, sometidas a esfuerzos cortantes en su plano. Las resistencias al corte por micro y macromodelo son uno por ciento menor y cinco por ciento mayor que las experimentales, respectivamente, mientras que la resistencia al corte por micromodelo es cinco por ciento menor que la del macromodelo. El micromodelo permite conseguir una aproximación razonable a la realidad experimental, que podría mejorarse si en el mismo se implementaran nuevos mecanismos de falla que no están contemplados en la versión del Programa utilizado. En el análisis numérico, el acero de refuerzo no presentó plastificación en toda la historia de cargas. En el micro y macromodelo, el acero trabaja sólo al diez y treinta y ocho por ciento, respectivamente.

  17. Efectos adversos de la acumulación renal de hemoproteínas. Nuevas herramientas terapéuticas

    Directory of Open Access Journals (Sweden)

    Melania Guerrero-Hue

    2018-01-01

    Full Text Available La hemoglobina y la mioglobina son hemoproteínas que juegan un papel fundamental en el organismo ya que participan en el transporte de oxígeno. Sin embargo, debido a su estructura química, estas moléculas pueden ejercer efectos deletéreos cuando se liberan al torrente sanguíneo de forma masiva, como sucede en determinadas condiciones patológicas asociadas a rabdomiólisis o hemólisis intravascular. Una vez en el plasma, estas hemoproteínas se pueden filtrar y acumular en el riñón, donde resultan citotóxicas, principalmente para el epitelio tubular, e inducen fracaso renal agudo y enfermedad renal crónica. En la presente revisión analizaremos los distintos contextos patológicos que provocan la acumulación renal de estas hemoproteínas, su relación con la pérdida de función renal a corto y largo plazo, los mecanismos fisiopatólogicos responsables de sus efectos adversos y los sistemas de defensa que contrarrestan tales acciones. Por último, describiremos los distintos tratamientos utilizados actualmente y mostraremos nuevas opciones terapéuticas basadas en la identificación de nuevas dianas celulares y moleculares, prestando especial atención a los diversos ensayos clínicos que se encuentran en marcha en la actualidad.

  18. Pharmaceuticals, alkylphenols and pesticides in Mediterranean coastal waters: Results from a pilot survey using passive samplers

    Science.gov (United States)

    Munaron, Dominique; Tapie, Nathalie; Budzinski, Hélène; Andral, Bruno; Gonzalez, Jean-Louis

    2012-12-01

    21 pharmaceuticals, 6 alkylphenols and 27 hydrophilic pesticides and biocides were investigated using polar organic contaminant integrative samplers (POCIS) during a large-scale study of contamination of French Mediterranean coastal waters. Marine and transitional water-bodies, defined under the EU Water Framework Directive were monitored. Our results show that the French Mediterranean coastal waters were contaminated with a large range of emerging contaminants, detected at low concentrations during the summer season. Caffeine, carbamazepine, theophilline and terbutaline were detected with a detection frequency higher than 83% in the coastal waters sampled, 4-nonylphenol (4-NP), 4-tert-octylphenol (4-OP) and 4-nonylphenol diethoxylate (NP2EO) were detected in all coastal waters sampled, and diuron, terbuthylazine, atrazine, irgarol and simazine were detected in more than 77% of samples. For pharmaceuticals, highest time-weighted average (TWA) concentrations were measured for caffeine and carbamazepine (32 and 12 ng L-1, respectively). For alkylphenols, highest TWA concentrations were measured for 4-nonylphenol mono-ethoxylate and 4-nonylphenol (41 and 33 ng L-1, respectively), and for herbicides and biocides, they were measured for diuron and irgarol (33 and 2.5 ng L-1, respectively). Except for Diana lagoon, lagoons and semi-enclosed bays were the most contaminated areas for herbicides and pharmaceuticals, whilst, for alkylphenols, levels of contamination were similar in lagoons and coastal waters. This study demonstrates the relevance and utility of POCIS as quantitative tool for measuring low concentrations of emerging contaminants in marine waters.

  19. Thinking in systems a primer

    CERN Document Server

    Meadows, Donella H

    2008-01-01

    In the years following her role as the lead author of the international bestseller, "Limits to Growth"-the first book to show the consequences of unchecked growth on a finite planet- Donella Meadows remained a pioneer of environmental and social analysis until her untimely death in 2001. Meadows' newly released manuscript, "Thinking in Systems", is a concise and crucial book offering insight for problem solving on scales ranging from the personal to the global. Edited by the Sustainability Institute's Diana Wright, this essential primer brings systems thinking out of the realm of computers and equations and into the tangible world, showing readers how to develop the systems-thinking skills that thought leaders across the globe consider critical for 21st-century life. Some of the biggest problems facing the world-war, hunger, poverty, and environmental degradation-are essentially system failures. They cannot be solved by fixing one piece in isolation from the others, because even seemingly minor details have e...

  20. ESTUDIOS DE PATOLOGÍA MOLECULAR UTILIZADOS PARA EVALUAR LA AMPLIFICACIÓN DEL ONCOGÉN HER2 EN CÁNCER DE MAMA. OPINIÓN CLÍNICA

    Directory of Open Access Journals (Sweden)

    Luz Fernanda Sua

    2014-12-01

    Full Text Available La importancia en la detección de la amplificación de oncogén HER2, es esencial en el cáncer de mama puesto que estas pacientes no responden a los tratamientos de quimioterapia y hormonales convencionales, traduciéndose así en una menor sobrevida. La determinación del oncogén HER2 tiene un papel crucial como diana terapéutica del trastuzumab. A continuación describiremos estas metodologías las cuales son: la técnica de hibridación in situ fluorescente (FISH, la hibridación in situ cromogénica (CISH y la técnica hibridación in situ cromogénica y con plata (Dual ISH, métodos usados para el estudio del oncogén HER2, en la selección correcta de las pacientes con cáncer de mama que son candidatas a recibir trastuzumab, teniendo una gran utilidad e impacto clínico. Palabras clave: Amplificación HER2, Hibridación in situ fluorescente (FISH, Hibridación in situ cromogénica (CISH e Hibridación in situ cromogénica y con plata (DISH.

  1. Evaluadores de este Número

    Directory of Open Access Journals (Sweden)

    Comité Editorial

    2017-03-01

    Full Text Available Evaluadores NacionalesMagdalena Arnao, Universidad Nacional de CórdobaMaría Gabriela Chaparro, Universidad Nacional del Centro de la Pcia. de Buenos AiresEmilio Crenzel, Universidad de Buenos AiresDaniel Feierstein, Universidad Nacional de Tres de FebreroAna María Gorosito Kramer, Universidad Nacional de MisionesAnne Gustavsson, Universidad Nacional de San MartínPaula Silvana Novellino, Museo de Ciencias Naturales y Antropológicas Juan Cornelio MoyanoNatalia Ojeda, Universidad Nacional del Centro de la Pcia. de Buenos AiresFrancisco Pazzarelli, Universidad Nacional de CórdobaJaime Peire, Universidad Nacional de Tres de FebreroAna Ramos, Universidad Nacional de Río NegroAgustina Rodríguez Romero, Universidad Nacional de Tres de FebreroCarlos Salamanca, Flacso – Argentina.Jorge Suby, Universidad Nacional del Centro de la Pcia. de Buenos AiresEvaluadores Extranjeros  Karina Biondi, Universidade Estadual de Campinas, BrasilVincent Hirtzel, Centre National de la Recherche Scientifique – CNRS, FranciaMaría Isabel Jociles Rubio, Universidad Compultense de Madrid, EspañaLiuba Kogan, Universidad del Pacífico, PerúDiana Marre, Universidad Autónoma de Barcelona, EspañaMario Ruffer, Universidad Autónoma Metropolitana, México

  2. Adherence to WCRF/AICR cancer prevention recommendations and metabolic syndrome in breast cancer patients.

    Science.gov (United States)

    Bruno, Eleonora; Gargano, Giuliana; Villarini, Anna; Traina, Adele; Johansson, Harriet; Mano, Maria Piera; Santucci De Magistris, Maria; Simeoni, Milena; Consolaro, Elena; Mercandino, Angelica; Barbero, Maggiorino; Galasso, Rocco; Bassi, Maria Chiara; Zarcone, Maurizio; Zagallo, Emanuela; Venturelli, Elisabetta; Bellegotti, Manuela; Berrino, Franco; Pasanisi, Patrizia

    2016-01-01

    Metabolic syndrome (MetS), conventionally defined by the presence of at least three out of five dismetabolic traits (abdominal obesity, hypertension, low plasma HDL-cholesterol and high plasma glucose and triglycerides), has been associated with both breast cancer (BC) incidence and prognosis. We investigated the association between the prevalence of MetS and a score of adherence to the World Cancer Research Fund (WCRF) and American Institute for Cancer Research (AICR) recommendations for the prevention of cancer in a cross-sectional study of BC patients. The DIet and ANdrogen-5 study (DIANA-5) for the prevention of BC recurrences recruited 2092 early stage BC survivors aged 35-70. At recruitment, all women completed a 24-hour food frequency and physical activity diary on their consumption and activity of the previous day. Using these diaries we created a score of adherence to five relevant WCRF/AICR recommendations. The prevalence ratios (PRs) and 95% confidence intervals (CIs) of MetS associated with the number of recommendations met were estimated using a binomial regression model. The adjusted PRs of MetS decreased with increasing number of recommendations met (p < 0.001). Meeting all the five recommendations versus meeting none or only one was significantly associated with a 57% lower MetS prevalence (95% CI 0.35-0.73). Our results suggest that adherence to WCRF/AICR recommendations is a major determinant of MetS and may have a clinical impact. © 2015 UICC.

  3. The social consequences of conspiracism: Exposure to conspiracy theories decreases intentions to engage in politics and to reduce one's carbon footprint.

    Science.gov (United States)

    Jolley, Daniel; Douglas, Karen M

    2014-02-01

    The current studies explored the social consequences of exposure to conspiracy theories. In Study 1, participants were exposed to a range of conspiracy theories concerning government involvement in significant events such as the death of Diana, Princess of Wales. Results revealed that exposure to information supporting conspiracy theories reduced participants' intentions to engage in politics, relative to participants who were given information refuting conspiracy theories. This effect was mediated by feelings of political powerlessness. In Study 2, participants were exposed to conspiracy theories concerning the issue of climate change. Results revealed that exposure to information supporting the conspiracy theories reduced participants' intentions to reduce their carbon footprint, relative to participants who were given refuting information, or those in a control condition. This effect was mediated by powerlessness with respect to climate change, uncertainty, and disillusionment. Exposure to climate change conspiracy theories also influenced political intentions, an effect mediated by political powerlessness. The current findings suggest that conspiracy theories may have potentially significant social consequences, and highlight the need for further research on the social psychology of conspiracism. © 2012 The British Psychological Society.

  4. Global health care leadership development: trends to consider

    Directory of Open Access Journals (Sweden)

    MacPhee M

    2013-06-01

    Full Text Available Maura MacPhee,1 Lilu Chang,2 Diana Lee,3 Wilza Spiri4 1University of British Columbia School of Nursing, Vancouver, British Columbia, Canada; 2Center for Advancement of Nursing Education, Koo Foundation, Sun Yat-Sen Cancer Center, Taipei, Taiwan; 3Nethersole School of Nursing, Chinese University of Hong Kong, Hong Kong, 4São Paulo State University, Botucatu, São Paulo, Brazil Abstract: This paper provides an overview of trends associated with global health care leadership development. Accompanying these trends are propositions based on current available evidence. These testable propositions should be considered when designing, implementing, and evaluating global health care leadership development models and programs. One particular leadership development model, a multilevel identity model, is presented as a potential model to use for leadership development. Other, complementary approaches, such as positive psychology and empowerment strategies, are discussed in relation to leadership identity formation. Specific issues related to global leadership are reviewed, including cultural intelligence and global mindset. An example is given of a nurse leadership development model that has been empirically tested in Canada. Through formal practice–academic–community collaborations, this model has been locally adapted and is being used for nurse leader training in Hong Kong, Taiwan, and Brazil. Collaborative work is under way to adapt the model for interprofessional health care leadership development. Keywords: health care leadership, development models, global trends, collective

  5. Picasso Paintings, Moon Rocks, and Hand-Written Beatles Lyrics: Adults' Evaluations of Authentic Objects.

    Science.gov (United States)

    Frazier, Brandy N; Gelman, Susan A; Wilson, Alice; Hood, Bruce

    2009-01-01

    Authentic objects are those that have an historical link to a person, event, time, or place of some significance (e.g., original Picasso painting; gown worn by Princess Diana; your favorite baby blanket). The current study examines everyday beliefs about authentic objects, with three primary goals: to determine the scope of adults' evaluation of authentic objects, to examine such evaluation in two distinct cultural settings, and to determine whether a person's attachment history (i.e., whether or not they owned an attachment object as a child) predicts evaluation of authentic objects. We found that college students in the U.K. (N = 125) and U.S. (N = 119) consistently evaluate a broad range of authentic items as more valuable than matched control (inauthentic) objects, more desirable to keep, and more desirable to touch, though only non-personal authentic items were judged to be more appropriate for display in a museum. These patterns were remarkably similar across the two cultural contexts. Additionally, those who had an attachment object as a child evaluated objects more favorably, and in particular judged authentic objects to be more valuable. Altogether, these results demonstrate broad endorsement of "positive contagion" among college-educated adults.

  6. Picasso Paintings, Moon Rocks, and Hand-Written Beatles Lyrics: Adults’ Evaluations of Authentic Objects

    Science.gov (United States)

    Frazier, Brandy N.; Gelman, Susan A.; Wilson, Alice; Hood, Bruce

    2010-01-01

    Authentic objects are those that have an historical link to a person, event, time, or place of some significance (e.g., original Picasso painting; gown worn by Princess Diana; your favorite baby blanket). The current study examines everyday beliefs about authentic objects, with three primary goals: to determine the scope of adults’ evaluation of authentic objects, to examine such evaluation in two distinct cultural settings, and to determine whether a person’s attachment history (i.e., whether or not they owned an attachment object as a child) predicts evaluation of authentic objects. We found that college students in the U.K. (N = 125) and U.S. (N = 119) consistently evaluate a broad range of authentic items as more valuable than matched control (inauthentic) objects, more desirable to keep, and more desirable to touch, though only non-personal authentic items were judged to be more appropriate for display in a museum. These patterns were remarkably similar across the two cultural contexts. Additionally, those who had an attachment object as a child evaluated objects more favorably, and in particular judged authentic objects to be more valuable. Altogether, these results demonstrate broad endorsement of "positive contagion" among college-educated adults. PMID:20631919

  7. Fate of Escherichia coli O157:H7, Salmonella and Listeria innocua on minimally-processed peaches under different storage conditions.

    Science.gov (United States)

    Alegre, Isabel; Abadias, Maribel; Anguera, Marina; Usall, Josep; Viñas, Inmaculada

    2010-10-01

    Consumption of fresh-cut produce has sharply increased recently causing an increase of foodborne illnesses associated with these products. As generally, acidic fruits are considered 'safe' from a microbiological point of view, the aim of this work was to study the growth and survival of Escherichia coli O157:H7, Salmonella and Listeria innocua on minimally-processed peaches. The three foodborne pathogens population increased more than 2 log(10)units on fresh-cut peach when stored at 20 and 25 degrees C after 48 h. At 10 degrees C only L. innocua grew more than 1 log(10)unit and it was the only pathogen able to grow at 5 degrees C. Differences in growth occurred between different peach varieties tested, with higher population increases in those varieties with higher pH ('Royal Glory' 4.73+/-0.25 and 'Diana' 4.12+/-0.18). The use of common strategies on extending shelf life of fresh-cut produce, as modified atmosphere packaging and the use of the antioxidant substance, ascorbic acid (2%w/v), did not affect pathogens' growth at any of the temperatures tested (5 and 25 degrees C). Minimally-processed peaches have shown to be a good substrate for foodborne pathogens' growth regardless use of modified atmosphere and ascorbic acid. Therefore, maintaining cold chain and avoiding contamination is highly necessary. 2010 Elsevier Ltd. All rights reserved.

  8. A study on family communication pattern and parenting styles with quality of life in adolescent

    International Nuclear Information System (INIS)

    Sanavi, F.S.; Baghbanian, A.; Shovey, M.F.; Moghaddam, A.A

    2013-01-01

    Objective: To investigate the relationship between parenting styles and family communication patterns with adolescent's quality of life. Methods: The cross-sectional study was carried out on 439 randomly selected adolescents in the city of Zahedan, Iran, from January to July 2011. The subjects were asked to complete the KIDSCREEN-52 health-related quality of life questionnaire, while their parents were asked to complete the Diana Brinder's Test to show their parenting styles. SPSS 15 was used to analyse data. Results: Most parents had authoritative parenting style (n=380; 86.6%). Pluralistic (n=170; 38.7%) and consensual (n=152; 34.6%) patterns were the most frequent styles of communication in families. Data suggested a significant relationship between parenting style and some dimensions of quality of life, including physical well-being, psychological well-being, social support and peers, and autonomy (p<0.05). There was also a significant relationship between family communication patterns and parent relation and home life (p<0.001) as well as autonomy (p<0.006). Conclusion: Families play a critical role in increasing adolescents, health-related quality-of-life. Effort should be made to address problems facing parents while raising their children. (author)

  9. In Situ Boundary Layer Coral Metabolism in the Atlantic Ocean Acidification Test Bed

    Science.gov (United States)

    McGillis, Wade

    2013-04-01

    and Chris Langdon, Brice Loose, Dwight Gledhill, Diana Hsueh, Derek Manzello, Ian Enochs, Ryan Moyer We present net ecosystem productivity (nep) and net ecosystem calcification (nec) in coral and seagrass ecosystems using the boundary layer gradient flux technique (CROSS). Coastal anthropogenic inputs and changes in global ocean chemistry in response to rising levels of atmospheric carbon dioxide has emerged in recent years as a topic of considerable concern. Coral reefs are particularly vulnerable from eroded environmental conditions including ocean acidification and water pollution. The Atlantic Ocean Acidification Testbed (AOAT) project monitors metabolism to ascertain the continuing health of coral reef ecosystems. The CROSS boundary layer nep/nec approach is one component of this diagnostic program. Certification of CROSS as an operational monitoring tool is underway in the AOAT. CROSS inspects a benthic community and measures productivity/respiration and calcification/dissolution over an area of 10 square meters. Being a boundary layer tool, advection and complex mesoscale flows are not a factor or concern and CROSS is autonomous and can be used at deep benthic sites. The interrogation area is not enclosed therefore exposed to ambient light, flow, and nutrient levels. CROSS is easy to deploy, unambiguous, and affordable. Repeated measurements have been made from 2011-2012 in reefal systems in La Parguera Puerto Rico and the Florida Keys, USA. Diurnal, seasonal and regional metabolism will be compared and discussed. The ability to accurately probe benthic ecosystems provides a powerful management and research tool to policy makers and researchers.

  10. The Sacred Mountain of Varallo in Italy: Seismic Risk Assessment by Acoustic Emission and Structural Numerical Models

    Directory of Open Access Journals (Sweden)

    Alberto Carpinteri

    2013-01-01

    Full Text Available We examine an application of Acoustic Emission (AE technique for a probabilistic analysis in time and space of earthquakes, in order to preserve the valuable Italian Renaissance Architectural Complex named “The Sacred Mountain of Varallo.” Among the forty-five chapels of the Renaissance Complex, the structure of the Chapel XVII is of particular concern due to its uncertain structural condition and due to the level of stress caused by the regional seismicity. Therefore, lifetime assessment, taking into account the evolution of damage phenomena, is necessary to preserve the reliability and safety of this masterpiece of cultural heritage. A continuous AE monitoring was performed to assess the structural behavior of the Chapel. During the monitoring period, a correlation between peaks of AE activity in the masonry of the “Sacred Mountain of Varallo” and regional seismicity was found. Although the two phenomena take place on very different scales, the AE in materials and the earthquakes in Earth’s crust, belong to the same class of invariance. In addition, an accurate finite element model, performed with DIANA finite element code, is presented to describe the dynamic behavior of Chapel XVII structure, confirming visual and instrumental inspections of regional seismic effects.

  11. The Sacred Mountain of Varallo in Italy: seismic risk assessment by acoustic emission and structural numerical models.

    Science.gov (United States)

    Carpinteri, Alberto; Lacidogna, Giuseppe; Invernizzi, Stefano; Accornero, Federico

    2013-01-01

    We examine an application of Acoustic Emission (AE) technique for a probabilistic analysis in time and space of earthquakes, in order to preserve the valuable Italian Renaissance Architectural Complex named "The Sacred Mountain of Varallo." Among the forty-five chapels of the Renaissance Complex, the structure of the Chapel XVII is of particular concern due to its uncertain structural condition and due to the level of stress caused by the regional seismicity. Therefore, lifetime assessment, taking into account the evolution of damage phenomena, is necessary to preserve the reliability and safety of this masterpiece of cultural heritage. A continuous AE monitoring was performed to assess the structural behavior of the Chapel. During the monitoring period, a correlation between peaks of AE activity in the masonry of the "Sacred Mountain of Varallo" and regional seismicity was found. Although the two phenomena take place on very different scales, the AE in materials and the earthquakes in Earth's crust, belong to the same class of invariance. In addition, an accurate finite element model, performed with DIANA finite element code, is presented to describe the dynamic behavior of Chapel XVII structure, confirming visual and instrumental inspections of regional seismic effects.

  12. Laser thermal ablation of multidrug-resistant bacteria using functionalized gold nanoparticles

    Directory of Open Access Journals (Sweden)

    Mocan L

    2017-03-01

    Full Text Available Lucian Mocan,1,2 Flaviu A Tabaran,3 Teodora Mocan,2,4 Teodora Pop,5 Ofelia Mosteanu,5 Lucia Agoston-Coldea,6 Cristian T Matea,2 Diana Gonciar,2 Claudiu Zdrehus,1,2 Cornel Iancu1 13rd Department of General Surgery, “Iuliu Hatieganu” University of Medicine and Pharmacy, 2Department of Nanomedicine, “Octavian Fodor” Gastroenterology Institute, 3Department of Pathology, University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, 4Department of Physiology, 53rd Gastroenterology Department, 6Department of Internal Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania Abstract: The issue of multidrug resistance (MDR has become an increasing threat to public health. One alternative strategy against MDR bacteria would be to construct therapeutic vectors capable of physically damaging these microorganisms. Gold nanoparticles hold great promise for the development of such therapeutic agents, since the nanoparticles exhibit impressive properties, of which the most important is the ability to convert light into heat. This property has scientific significance since is exploited to develop nano-photothermal vectors to destroy bacteria at a molecular level. The present paper summarizes the latest advancements in the field of nanotargeted laser hyperthermia of MDR bacteria mediated by gold nanoparticles. Keywords: bacteria, photo-thermal ablation, gold nanoparticles, antibiotic resistance

  13. Multiscale Thermo-Mechanical Design and Analysis of High Frequency and High Power Vacuum Electron Devices

    Science.gov (United States)

    Gamzina, Diana

    Diana Gamzina March 2016 Mechanical and Aerospace Engineering Multiscale Thermo-Mechanical Design and Analysis of High Frequency and High Power Vacuum Electron Devices Abstract A methodology for performing thermo-mechanical design and analysis of high frequency and high average power vacuum electron devices is presented. This methodology results in a "first-pass" engineering design directly ready for manufacturing. The methodology includes establishment of thermal and mechanical boundary conditions, evaluation of convective film heat transfer coefficients, identification of material options, evaluation of temperature and stress field distributions, assessment of microscale effects on the stress state of the material, and fatigue analysis. The feature size of vacuum electron devices operating in the high frequency regime of 100 GHz to 1 THz is comparable to the microstructure of the materials employed for their fabrication. As a result, the thermo-mechanical performance of a device is affected by the local material microstructure. Such multiscale effects on the stress state are considered in the range of scales from about 10 microns up to a few millimeters. The design and analysis methodology is demonstrated on three separate microwave devices: a 95 GHz 10 kW cw sheet beam klystron, a 263 GHz 50 W long pulse wide-bandwidth sheet beam travelling wave tube, and a 346 GHz 1 W cw backward wave oscillator.

  14. [The woman in neurosurgery at the national institute of neurology and neurosurgery].

    Science.gov (United States)

    Mejía-Pérez, Sonia Iliana; Cervera-Martínez, Claudia; Sánchez-Correa, Thalía Estefanía; Corona-Vázquezo, Teresa

    Women have always had a hard time in the history of medicine; Dr. Isabel Blackwell was the first woman in history to practice medicine. Dr. Diana Beck became the world´s first female neurosurgeon. The first Latin American female neurosurgeon was Dr. María Cristina García Sancho y Álvarez-Tostado. All of these women had to face a large number of social, cultural, and economic obstacles in their path; however, this situation has changed gradually. Dr. Ana Lilia Siordia Karam was the first neurosurgeon to graduate from INNN. Nineteen years later the second female neurosurgeon at this institute was Dr. María Petra Herrera Guerrero. During their time at this institute they endured a lot of difficulties, especially with most of their coworkers; however, some coworkers treated them with respect and no gender distinction. Nowadays, four of the 25 total neurosurgery residents at INNN are women, and even though some of them have had to endure acts of gender discrimination, the general situation has changed. With work and respect, women have managed to have a larger role in the surgical field. We hope that in the near future a gender discrimination-free environment will be achieved in medicine and its specialties.

  15. Numerical modelling techniques of soft soil improvement via stone columns: A brief review

    Science.gov (United States)

    Zukri, Azhani; Nazir, Ramli

    2018-04-01

    There are a number of numerical studies on stone column systems in the literature. Most of the studies found were involved with two-dimensional analysis of the stone column behaviour, while only a few studies used three-dimensional analysis. The most popular software utilised in those studies was Plaxis 2D and 3D. Other types of software that used for numerical analysis are DIANA, EXAMINE, ZSoil, ABAQUS, ANSYS, NISA, GEOSTUDIO, CRISP, TOCHNOG, CESAR, GEOFEM (2D & 3D), FLAC, and FLAC 3. This paper will review the methodological approaches to model stone column numerically, both in two-dimensional and three-dimensional analyses. The numerical techniques and suitable constitutive model used in the studies will also be discussed. In addition, the validation methods conducted were to verify the numerical analysis conducted will be presented. This review paper also serves as a guide for junior engineers through the applicable procedures and considerations when constructing and running a two or three-dimensional numerical analysis while also citing numerous relevant references.

  16. Meeting report of the first conference of the International Placenta Stem Cell Society (IPLASS)

    Science.gov (United States)

    Parolini, O.; Alviano, F.; Betz, A.G.; Bianchi, D.W.; Götherström, C.; Manuelpillai, U.; Mellor, A.L.; Ofir, R.; Ponsaerts, P.; Scherjon, S.A.; Weiss, M.L.; Wolbank, S.; Wood, K.J.; Borlongan, C.V.

    2012-01-01

    The International Placenta Stem Cell Society (IPLASS) was founded in June 2010. Its goal is to serve as a network for advancing research and clinical applications of stem/progenitor cells isolated from human term placental tissues, including the amnio-chorionic fetal membranes and Wharton's jelly. The commitment of the Society to champion placenta as a stem cell source was realized with the inaugural meeting of IPLASS held in Brescia, Italy, in October 2010. Officially designated as an EMBO-endorsed scientific activity, international experts in the field gathered for a 3-day meeting, which commenced with “Meet with the experts” sessions, IPLASS member and board meetings, and welcome remarks by Dr. Ornella Parolini, President of IPLASS. The evening's highlight was a keynote plenary lecture by Dr. Diana Bianchi. The subsequent scientific program consisted of morning and afternoon oral and poster presentations, followed by social events. Both provided many opportunities for intellectual exchange among the 120 multi-national participants. This allowed a methodical and deliberate evaluation of the status of placental cells in research in regenerative and reparative medicine. The meeting concluded with Dr. Parolini summarizing the meeting's highlights. This further prepared the fertile ground on which to build the promising potential of placental cell research. The second IPLASS meeting will take place in September 2012 in Vienna, Austria. This meeting report summarizes the thought-provoking lectures delivered at the first meeting of IPLASS. PMID:21575989

  17. Immunotherapy for the treatment of Alzheimer's disease: amyloid-β or tau, which is the right target?

    Directory of Open Access Journals (Sweden)

    Castillo-Carranza DL

    2013-12-01

    Full Text Available Diana L Castillo-Carranza,1,2 Marcos J Guerrero-Muñoz,1,2 Rakez Kayed1–31Mitchell Center for Neurodegenerative Diseases, 2Departments of Neurology, Neuroscience, and Cell Biology, 3Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX, USAAbstract: Alzheimer's disease (AD is characterized by the presence of amyloid plaques composed mainly of amyloid-β (Aβ protein. Overproduction or slow clearance of Aβ initiates a cascade of pathologic events that may lead to formation of neurofibrillary tangles, neuronal cell death, and dementia. Although immunotherapy in animal models has been demonstrated to be successful at removing plaques or prefibrillar forms of Aβ, clinical trials have yielded disappointing results. The lack of substantial cognitive improvement obtained by targeting Aβ raises the question of whether or not this is the correct target. Another important pathologic process in the AD brain is tau aggregation, which seems to become independent once initiated. Recent studies targeting tau in AD mouse models have displayed evidence of cognitive improvement, providing a novel therapeutic approach for the treatment of AD. In this review, we describe new advances in immunotherapy targeting Aβ peptide and tau protein, as well as future directions.Keywords: immunotherapy, Alzheimer's disease, β-amyloid, tau

  18. The need for affect: individual differences in the motivation to approach or avoid emotions.

    Science.gov (United States)

    Maio, G R; Esses, V M

    2001-08-01

    The present research developed and tested a new individual-difference measure of the need for affect, which is the motivation to approach or avoid emotion-inducing situations. The first phase of the research developed the need for affect scale. The second phase revealed that the need for affect is related to a number of individual differences in cognitive processes (e.g., need for cognition, need for closure), emotional processes (e.g., affect intensity, repression-sensitization), behavioral inhibition and activation (e.g., sensation seeking), and aspects of personality (Big Five dimensions) in the expected directions, while not being redundant with them. The third phase of the research indicated that, compared to people low in the need for affect, people high in the need for affect are more likely to (a) possess extreme attitudes across a variety of issues, (b) choose to view emotional movies, and (c) become involved in an emotion-inducing event (the death of Princess Diana). Overall, the results indicate that the need for affect is an important construct in understanding emotion-related processes.

  19. Revisiting play elements and self-handicapping in play: a comparative ethogram of five Old World monkey species.

    Science.gov (United States)

    Petrů, Milada; Spinka, Marek; Charvátová, Veronika; Lhota, Stanislav

    2009-08-01

    Play behavior has been viewed as a mixture of elements drawn from "serious" behavior, interspersed by ritualized play signals. Two other types of play behaviors have been overlooked: patterns that are dissimilar from any serious behavior and patterns with self-handicapping character, that is, those that put the animal into unnecessary disadvantageous positions or situations. Here the authors show that these 2 types of patterns can constitute a major part of play repertoire. From our own videorecordings and observations, we constructed play ethograms of 5 monkey species (Semnopithecus entellus, Erythrocebus patas, Chlorocebus pygerythrus, Cercopithecus neglectus, and Cercopithecus diana). The authors evaluated the self-handicapping character of each pattern and in Hanuman langurs also the (dis)similarity to serious behavior. Of the 74 patterns in the 5 species, 33 (45%) were judged to have a self-handicapping character. Of 48 patterns observed in langurs, 16 (33%) were totally dissimilar to any serious langur behavior known to us. The authors discuss the possibility that the different types of play elements may have different functions in play. Copyright 2009 APA, all rights reserved.

  20. Where we were in 1998, and how this legacy shaped the next 20 years

    Science.gov (United States)

    Moran, E. F.

    2017-12-01

    When the National Research Council Committee on Human Dimensions of Global Change decided to convene a gathering of social scientists and remote sensing researchers in 1997 we wanted to know the state-of-knowledge and particularly what challenges those who were beginning to make this linkage had found. Diana Liverman as Chair of the Committee invited Emilio Moran and Ronald Rindfuss from UNC to join her and Paul Stern, from NRC, to organize the meeting, and the resulting volume with support from NASA. In 1997 we were just getting started. Most of us at the meeting had just engaged remote sensing in the past 5 years or so, and each team invited had very different approaches to how to make this linkage (do all have to know and do RS? Or is there a clear division of labor between the social and the remote? The meeting and the intro and concluding chapter of People and Pixels provided a roadmap for the future. This paper will discuss which directions proved to be most significant in advancing this linkage, and what surprises have emerged along the way to advance the linking of remote sensing approaches with the questions that interest social science and the global environmental change community.

  1. [Gynecology and obstetrics in Ancient Rome].

    Science.gov (United States)

    Dumont, M

    1992-10-01

    Gods and Goddesses were invoked by the Romans for the termination of a good delivery. Diana, Juno, Lucina and Cybele were the preferred ones. Sterility was sometimes treated by the whip of the Lupercali of ministers of Pan. The first doctors in Rome were coming from Greece. Celsus, Pliny the Elder were encyclopedists, Rufus an anatomist, Dioscorides a pharmacologist. Archigenes, Aretaeus and Antyllus surgeons. Soranus from Ephesus, was the first to recommend podalic version. His works was a long time buried in a profound oblivion and discovered by scholars during the nineteenth century. Galen was looked as the most famous medical man after Hippocrates. During the Roman Empire of Occident (Byzantine Empire), Oribasius, Aurelianus Caelius, Moschion and above all Aetius and Paul of Aegina wrote many works which were many times plagiarized. Roman laws concerning public health were severe. Midwives took an important action in the care of pregnant women. Roman poets as Plautus, Terence, Lucilius, Catullus, Virgil, Tibullus, Ovid and Martial were many times concerned in their writings with gynecologic or obstetric subjects. Children were easily forsaken. Three Emperors, Trajan, Marcus-Aurelius and Alexander Severius, a writer, Aulu-Gelles, and a rhetor, Quintilian, took protection of them.

  2. APROXIMACIONES COMPUTACIONALES PARA LA IDENTIFICACIÓN DE PROMOTORES EUCARIOTAS TIPO II

    Directory of Open Access Journals (Sweden)

    M. Mejía-Guerra

    2006-06-01

    Full Text Available La identificación de segmentos funcionales dentro del DNA es uno de los campos más estudiados en la actualidad, debido a la generación de grandes volúmenes de información a partir de los proyectosgenómicos, las predicciones computacionales han atraído la atención de la comunidad científica en general.En este marco la identificación de secuencias reguladoras se erige como un importante campo del análisis de genomas; sin embargo, dada la enorme complejidad del proceso de regulación de la transcripciónaunque promisorios el problema de la predicción de las zonas reguladoras no se ha solucionado en su totalidad.Este artículo presenta una descripción de algunas aproximaciones desarrolladas para la identificación de promotores y sus elementos cis-reguladores, también se describen las estructuras de señales funcionales y estructurales que son diana de reconocimiento de algunos de estos programas de predicción aplicados al gen que codifica para la subunidad NR1 del receptor de glutamato sensible a N-metil-D-aspartato (iGluR-NMDA el cual ha sido objeto de estudio desde la década de los noventa.

  3. Aptámeros: agentes diagnósticos y terapéuticos = Aptamers: diagnostic and therapeutic agents

    Directory of Open Access Journals (Sweden)

    Frank J Hernandez

    2012-04-01

    Full Text Available Los aptámeros son ácidos nucleicos de cadena sencilla, ADN o ARN, que reconocen una gran variedad de moléculas. Cada aptámero posee una estructura tridimensional particular que le permite unirse con afinidad y especificidad altas a la molécula diana. Los aptámeros tienen propiedades de reconocimiento equiparables a las de los anticuerpos; sin embargo, por la naturaleza de su composición tienen ventajas significativas en cuanto a su tamaño, producción y modificación. Estas características los hacen excelentes candidatos para el desarrollo de nuevas plataformas biotecnológicas. Se han identificado aptámeros con propiedades terapéuticas que han sido evaluados exitosamente en modelos animales; entre ellos, algunos se encuentran en fase clínica y uno ya fue aprobado para tratamiento por la FDA (Food and Drug Administration. Todos estos avances ocurridos durante las dos últimas décadas permiten anticipar el protagonismo que tendrán los aptámeros como agentes diagnósticos y terapéuticos en un futuro cercano.

  4. Aplicación de una biblioteca de anticuerpos lineales humanos frente al polisacárido capsular de Neisseria meningitidis serogrupo B

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    Emigdio León-Toirac

    2013-12-01

    Full Text Available Neisseria meningitidis serogrupo B produce aún morbimortalidad significativa. Su polisacárido capsular muestra similitud estructural con proteínas humanas y pobre inmunogenicidad, obstaculizando así el desarrollo de vacunas y anticuerpos monoclonales (AcM y policlonales contra esta bacteria. Recientemente se han creado bibliotecas artificiales de anticuerpos humanos expresados en bacteriófagos que reconocen específicamente a moléculas diana existentes, con la ventaja sobre los AcM convencionales por su rápida obtención, sin utilización de animales de laboratorio, lo que emerge como alternativa atractiva para la producción de AcM contra antígenos peculiares o complejos. Se realizó un trabajo de investigación básica, utilizando una biblioteca de fagos filamentosos que expresan constitutivamente regiones variables de anticuerpos humanos, que se enfrentó al polisacárido capsular de N. meningitidis serogrupo B. Los resultados que se obtuvieron mediante ELISA policlonal sugieren la existencia de anticuerpos humanos expresados en fagos que lo reconocen.

  5. Hubungan antara dukungan sosial dengan resiliensi yang dimoderatori oleh locus of control pada mahasiswa bidikmisi

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    Alaiya Choiril Mufidah

    2018-01-01

    Full Text Available Pendidikan merupakan hal yang sangat penting yang harus diberikan kepada semua orang di dunia, namun kadang berbagai alasan melatar belakangi individu tidak melanjutkan pendidikan pada jenjang yang lebih tinggi. Dan salah satu penyebab tidak melanjutkan pendidikan yakni masalah kurangnya biaya. Mahasiswa bidikmisi merupakan berlatar belakang dari mahasiswa yang mampu dalam segi akademik namun kurang mampu dalam segi ekonomi, sehingga mereka diberikan beasiswa oleh pemerintah untuk bisa melanjutkan ke jenjang pendidikan yang lebih tinggi. Penelitian ini bertujuan untuk mengetahui hubungan positif antara dukungan sosial dan resiliensi mahasiswa bidikmisi, untuk mengetahui hubungan positif antara locus of control dan resiliensi, dan untuk mengetahui hubungan positif antara dukungan social dan resiliensi dengan Locus of Control sebagai variabel moderator. Penelitian ini menggunakan metode kuantitatif dengan tehnik analisis regresi berganda. Skala Resiliensi adaptasi milik Connor & Davidson (CD-RISC, skala Locus of Control adaptasi milik Levinson (MLCS, dan skala Dukungan Sosial adaptasi tesis Diana Kamilin. Hubungan antara variabel X dan Y dengan LOC sebagai mediator. . Subjek penelitian adalah mahasiswa bidikmisi di UIN Malang sebanyak 80 subjek Hasil dari analisis menunjukkan bahwa terdapat hubungan yang positif antara dukungan social dan resiliensi dengan locus of control sebagai moderator dengan nilai signifikansi 0.431 (p

  6. Flavonoids in white and yellow perianths and yellow anthers of tulips (Tulipa gesneriana L.

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    Marcin Horbowicz

    2013-12-01

    Full Text Available The content of flavonoids in white and yellow perianths and yellow anthers of a few tulip cultivars were determined at the stage of full flowering. To analyses of flavonols a HPLC method was used. In anthers (yellow of all analyzed cultivars (Oscar, Pax, Profesor Wóycicki, Biała Dama, White Virgin, Calypso, Diana high content of quercetin (2,35 - 6,01 mg·g-1 F.W., kaempferol (1,09 - 9,47 mg·g-1 F.W. and apigenin (1,34 - 8,24 mg·g-1 F.W. was found. In analyzed white perianth of cvs. Oscar and White Virgin also high content of quercetin (1,3 - 1,80 mg·g-1 F.W. and kaempferol (1,90 mg·g-1 F.W. was documented and only traces of apigenin was found. In the yellow perianth of cv. Profesor Wóycicki the level of quercetin and kaempferol was much lower than in perianth of cvs. Oscar and White Virgin, and apigenin was absent. Thus, yellow anthers and white and yellow perianth of tulip cultivars are a rich source of flavonols.

  7. Multinarasi Relief Yeh Pulu Basis Penciptaan Seni Lukis Kontemporer

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    I Wayan Adnyana

    2018-05-01

    Full Text Available Kajian ini merupakan skema penelitian terapan, yang bertujuan untuk mengungkap konsep multinarasi relief Yeh Pulu, Bedulu, Gianyar, Bali, sebagai basis penciptaan seni lukis kontemporer. Secara metodologis penelitian ini dilakukan dalam dua tahapan: penelitian lapangan (kajian atas narasi relief berdasar perspektif ikonologi Panofsky (1971, dan berikutnya penelitian eksperimen terkait penciptaan seni lukis kontemporer berdasar perspektif ‘art practice as a research’ (Sullivan, 2005 yang menunjuk pada tiga tahapan: eksperimen medium, bahasa visual, dan penyusunan konteks yang relevan. Berdasar kajian ikonologi, terutama tahap analisis ikonografi, ditemukan bahwa narasi relief Yeh Pulu bersifat multinarasi, yakni pahatan relief yang memiliki beragam jenis tema cerita, seperti praktik pertanian, berburu, meditasi, pesta, asmara, dan lain-lain. Kemudian konsep multinarasi dalam penciptaan seni lukis kontemporer, menjadi: (a secara medium menggunakan multiteknik dan medium; (b bahasa visual, menghadirkan berbagai adegan secara berulang, terpadu dan bahkan terkesan saling berlawanan; (c konteks yang relevan, dengan memasukan ikon tokok-toko pahlawan dunia pop, seperti superman, superwomen, dan lain-lain. Secara ikonologis, bangunan visual yang mempertemukan adegan multinarasi relief Yeh Pulu dengan narasi kepahlawanan dunia pop, menjadi semakin menguatkan konsep multinarasi dalam membangun pesan kepahlawanan dunia sehari-hari dalam karya seni lukis kontemporer semakin berhasil. Penelitian ini melibatkan: Anak Agung Rai Remawa (pengumpul data, dan  Ni Luh Desi In Diana Sari (fotografi dan layout. This paper serves as an applied research scheme which aims to reveal the concept of multiple narratives of Yeh Pulu Relief, located in Bedulu, Bali, as the basis for the creation of contemporary painting. Methodologically speaking, this study was conducted in two stages: a field research (a field study on the relief narratives based on Panofsky

  8. Sun-protective behaviors in populations at high risk for skin cancer

    Directory of Open Access Journals (Sweden)

    Diao DY

    2013-12-01

    Full Text Available Diana Y Diao,1 Tim K Lee1,21Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada; 2Cancer Control Research Program, BC Cancer Agency, Vancouver, British Columbia, CanadaAbstract: Over 3 million new cases of skin cancer are diagnosed in the US annually. Melanoma, a subtype of skin cancer that can be fatal if the disease is not detected and treated at an early stage, is the most common cancer for those aged 25–29 years and the second most common cancer in adolescents and young adults aged 15–29 years. The primary carcinogen for the genesis of skin cancers is ultraviolet light from solar radiation and tanning beds. In spite of massive health campaigns to raise public awareness on ultraviolet radiation, sun-protective practices still fall behind. A plausible explanation is the lack of behavioral change in the populations at risk; in this review article, we examine sun-protective behavior in the four high-risk skin cancer groups: skin cancer survivors, individuals with a family history of melanoma, individuals with physical characteristics associated with skin cancer risk, and organ transplantation patients. Findings in the literature demonstrate that increased knowledge and awareness does not consequently translate into behavioral changes in practice. Behavior can differ as a result of different attitudes and beliefs, depending on the population at risk. Thus, intervention should be tailored to the population targeted. A multidisciplinary health team providing consultation and education is required to influence these much needed changes.Keywords: skin cancer, melanoma, risk, prevention, behaviour

  9. Long non-coding RNA TUG1 acts as a miR-26a sponge in human glioma cells.

    Science.gov (United States)

    Li, Jun; An, Gang; Zhang, Meng; Ma, Qingfang

    2016-09-02

    Long non-coding RNA taurine upregulated gene 1 (TUG1) acts as an important regulator in cancer pathogenesis; however, its functional mechanism in glioma development remains unclear. This study aims to explore the potential function of TUG1 in glioma by sponging miR-26a. The expression of TUG1, miR-26a, and phosphatase and tensin homolog (PTEN) in 20 paired glioma tissues was detected by quantitative real-time PCR and subjected to correlation analysis. Bioinformatics analysis was performed by using DIANA Tools. Abnormal TUG1 expression was conducted in two glioma cells to analyze its regulation on miR-26a and PTEN using real-time PCR, western blot, and luciferase reporter assay. TUG1 expression was confirmed to be upregulated in glioma tissues, and showed an inverse correlation with downregulated miR-26a. TUG1 could negatively regulate the expression of miR-26a in glioma cells. The bioinformatics prediction revealed putative miR-26a binding sites within TUG1 transcripts. Further experiments demonstrated the positive regulation of TUG1 on the miR-26a target, PTEN, wherein TUG1 could inhibit the negative regulation of miR-26a on PTEN by binding its 3'UTR. Additionally, the expression of PTEN was also upregulated in glioma tissues, showing a positive or negative correlation with TUG1 or miR-26a, respectively. TUG1 could serve as a miR-26a sponge in human glioma cells, contributing to the upregulation of PTEN. This study revealed a new TUG1/miR-26a/PTEN regulatory mechanism and provided a further understanding of the tumor-suppressive role of TUG1 in glioma development. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. The feasibility of using electronic clinical outcome assessments in people with schizophrenia and their informal caregivers

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    Tolley C

    2015-03-01

    Full Text Available Chloe Tolley,1 Diana Rofail,2 Adam Gater,1 Justine K Lalonde31Adelphi Values Ltd, Bollington, UK; 2Roche Products Ltd, Welwyn Garden City, UK; 3Roche S.A.S, Paris, France Abstract: Many clinical outcome assessments (COAs were originally developed for completion via pen and paper. However, in recent years there have been movements toward electronic capture of such data in an effort to reduce missing data, provide time-stamped records, minimize administrative burden, and avoid secondary data entry errors. Although established in many patient populations, the implications of using electronic COAs in schizophrenia are unknown. In accordance with International Society for Pharmacoeconomics and Outcomes Research (ISPOR Task Force recommendations, in-depth cognitive debriefing and usability interviews were conducted with people with schizophrenia (n=12, their informal (unpaid caregivers (n=12, and research support staff (n=6 to assess the suitability of administration of various electronic COA measures using an electronic tablet device. Minimal issues were encountered by participants when completing or administering the COAs in electronic format, with many finding it easier to complete instruments in this mode than by pen and paper. The majority of issues reported were specific to the device functionality rather than the electronic mode of administration. Findings support data collection via electronic tablet in people with schizophrenia and their caregivers. The appropriateness of other forms of electronic data capture (eg, smartphones, interactive voice response systems, etc is a topic for future investigation. Keywords: ePRO, eCOA, mode of administration, electronic data capture, usability 

  11. Recent Progress in GW-based Methods for Excited-State Calculations of Reduced Dimensional Systems

    Science.gov (United States)

    da Jornada, Felipe H.

    2015-03-01

    Ab initio calculations of excited-state phenomena within the GW and GW-Bethe-Salpeter equation (GW-BSE) approaches allow one to accurately study the electronic and optical properties of various materials, including systems with reduced dimensionality. However, several challenges arise when dealing with complicated nanostructures where the electronic screening is strongly spatially and directionally dependent. In this talk, we discuss some recent developments to address these issues. First, we turn to the slow convergence of quasiparticle energies and exciton binding energies with respect to k-point sampling. This is very effectively dealt with using a new hybrid sampling scheme, which results in savings of several orders of magnitude in computation time. A new ab initio method is also developed to incorporate substrate screening into GW and GW-BSE calculations. These two methods have been applied to mono- and few-layer MoSe2, and yielded strong environmental dependent behaviors in good agreement with experiment. Other issues that arise in confined systems and materials with reduced dimensionality, such as the effect of the Tamm-Dancoff approximation to GW-BSE, and the calculation of non-radiative exciton lifetime, are also addressed. These developments have been efficiently implemented and successfully applied to real systems in an ab initio framework using the BerkeleyGW package. I would like to acknowledge collaborations with Diana Y. Qiu, Steven G. Louie, Meiyue Shao, Chao Yang, and the experimental groups of M. Crommie and F. Wang. This work was supported by Department of Energy under Contract No. DE-AC02-05CH11231 and by National Science Foundation under Grant No. DMR10-1006184.

  12. PREFACE 16 ISCMP: Progress in Solid State and Molecular Electronics, Ionics and Photonics

    Science.gov (United States)

    Dimova-Malinovska, Doriana; Nesheva, Diana; Petrov, Alexander G.; Primatarowa, Marina T.

    2010-11-01

    We are pleased to introduce the Proceedings of the 16 ISCMP, organized by the Institute of Solid State Physics of the Bulgarian Academy of Sciences. The Chairman of the School was Professor Alexander G Petrov. The School was dedicated to the late Professor Joe Marshall, who served for a long time as Chairman and Honorary Chairman and left us just after having completed the proceedings of the previous School. Like previous events, the School took place in the beautiful Black Sea resort of Saint Constantine and Elena near Varna, going back to the renewed facilities of the Panorama hotel. Participants from 19 different countries delivered 34 invited lecturers and 75 posters, contributing to three sessions of poster presentations. Papers submitted to the Proceedings were refereed according to the high standards of the Journal of Physics: Conference Series and the articles published in this volume illustrate the diversity and the high level of the contributions. Not the least significant factor in the success of the 16 ISCMP was the social program, both the organized events (Welcome and Farewell Parties) and the variety of pleasant local restaurants and beaches. These Proceedings are published for the first time in Journal of Physics: Conference Series. We are grateful to the Journal's staff for encouraging this idea. The Scientific Committee of the ISCMP dedicates this volume of the Proceedings to the living memory of Professor Joe Marshall, Honorary Chairman of the ISCMP. The Committee decided that the next event will take place again in Saint Constantine and Elena, in September 2012. It will be entitled: Open Problems in Condensed Matter Physics, Biomedical Physics and their Applications. Doriana Dimova-Malinovska, Diana Nesheva, Alexander G Petrov and Marina T Primatarowa

  13. PREFACE: 17th International School on Condensed Matter Physics (ISCMP): Open Problems in Condensed Matter Physics, Biomedical Physics and their Applications

    Science.gov (United States)

    Dimova-Malinovska, Doriana; Nesheva, Diana; Pecheva, Emilia; Petrov, Alexander G.; Primatarowa, Marina T.

    2012-12-01

    We are pleased to introduce the Proceedings of the 17th International School on Condensed Matter Physics: Open Problems in Condensed Matter Physics, Biomedical Physics and their Applications, organized by the Institute of Solid State Physics of the Bulgarian Academy of Sciences. The Chairman of the School was Professor Alexander G Petrov. Like prior events, the School took place in the beautiful Black Sea resort of Saints Constantine and Helena near Varna, going back to the refurbished facilities of the Panorama hotel. Participants from 17 different countries delivered 31 invited lecturers and 78 posters, contributing through three sessions of poster presentations. Papers submitted to the Proceedings were refereed according to the high standards of the Journal of Physics: Conference Series and the accepted papers illustrate the diversity and the high level of the contributions. Not least significant factor for the success of the 17 ISCMP was the social program, both the organized events (Welcome and Farewell Parties) and the variety of pleasant local restaurants and beaches. Visits to the Archaeological Museum (rich in valuable gold treasures of the ancient Thracian culture) and to the famous rock monastery Aladja were organized for the participants from the Varna Municipality. These Proceedings are published for the second time by the Journal of Physics: Conference Series. We are grateful to the Journal's staff for supporting this idea. The Committee decided that the next event will take place again in Saints Constantine and Helena, 1-5 September 2014. It will be entitled: Challenges of the Nanoscale Science: Theory, Materials and Applications. Doriana Dimova-Malinovska, Diana Nesheva, Emilia Pecheva, Alexander G Petrov and Marina T Primatarowa Editors

  14. Solution structure of human intestinal fatty acid binding protein: Implications for ligand entry and exit

    International Nuclear Information System (INIS)

    Zhang Fengli; Luecke, Christian; Baier, Leslie J.; Sacchettini, James C.; Hamilton, James A.

    1997-01-01

    The human intestinal fatty acid binding protein (I-FABP) is a small (131 amino acids) protein which binds dietary long-chain fatty acids in the cytosol of enterocytes. Recently, an alanine to threonine substitution at position 54 in I-FABP has been identified which affects fatty acid binding and transport, and is associated with the development of insulin resistance in several populations including Mexican-Americans and Pima Indians. To investigate the molecular basis of the binding properties of I-FABP, the 3D solution structure of the more common form of human I-FABP (Ala54) was studied by multidimensional NMR spectroscopy.Recombinant I-FABP was expressed from E. coli in the presence and absence of 15N-enriched media. The sequential assignments for non-delipidated I-FABP were completed by using 2D homonuclear spectra (COSY, TOCSY and NOESY) and 3D heteronuclear spectra(NOESY-HMQC and TOCSY-HMQC). The tertiary structure of human I-FABP was calculated by using the distance geometry program DIANA based on 2519 distance constraints obtained from the NMR data. Subsequent energy minimization was carried out by using the program SYBYL in the presence of distance constraints. The conformation of human I-FABP consists of 10 antiparallel β-strands which form two nearly orthogonal β-sheets of five strands each, and two short α-helices that connect the β-strands A and B. The interior of the protein consists of a water-filled cavity between the two β-sheets. The NMR solution structure of human I-FABP is similar to the crystal structure of rat I-FABP.The NMR results show significant conformational variability of certain backbone segments around the postulated portal region for the entry and exit of fatty acid ligand

  15. Synanthropy of Sarcophagidae (Diptera in La Pintada, Antioquia-Colombia

    Directory of Open Access Journals (Sweden)

    Daniela Yepes-Gaurisas

    2013-09-01

    Full Text Available Recently, populations of flies have increased in numbers given the elevated levels of organic matter waste produced by anthropic activities and domestication of animals. Such increase represents a worldwide health concern, since flies can be vectors of human diseases. The great variety of feeding and developmental habits of flies of the family Sarcophagidae taking place on animal corpses, feces and decomposed organic matter make them potential vectors of pathogens. Herein, we evaluated the synanthropic index (SI, as well as other ecological aspects of this family, through simultaneous monthly samplings in three areas with different degrees of human disturbance (urban, rural and forest. Each area had four van Someren Rydon traps, each one with a different bait (i.e., human feces, chicken viscera, fish and decomposing onion. Traps were active during 48 hours each month, and specimen collection was made every 12 hours. A total of 7 446 Sarcophagidae individuals were collected (1 275 males and 6 171 females, belonging to 27 species and nine genera. Tricharaea (Sarcophagula canuta (SI=+96.67, Oxysarcodexia taitensis (SI=+93.85, Peckia (Peckia chrysostoma (SI=+90.00 and Tricharaea (Sarcophagula occidua (SI=+88.76 exhibited the highest values of synanthropy index, revealing a strong preference for human settlements. The most abundant species were Oxysarcodexia conclausa (21.80%, Ravinia effrenata (18.67%, Oxysarcodexia bakeri (11.45% and Oxysarcodexia taitensis (10.20%, all of which exhibited preference for urban environments. Additionally, we are reporting seven new records of Sarcophagid flies for Colombia: Oxysarcodexia angrensis, Oxysarcodexia bakeri, Oxysarcodexia diana, Oxysarcodexia similata, Oxysarcodexia timida, Peckia (Peckia pexata and Titanogrypa (Cucullomyia placida.

  16. Adenocarcinoma pulmonar metastásico con evolución favorable al tratamiento con ITK-EGFR en un paciente fumador

    Directory of Open Access Journals (Sweden)

    Joseph Jesús Exebio Jara

    2015-04-01

    Full Text Available Introducción: El cáncer de pulmón es el cáncer con mayor mortalidad en ambos sexos. El esquema de manejo actual del adenocarcinoma pulmonar incluye determinar el estado mutacional del receptor del factor de crecimiento epidérmico (EGFR, por ser la diana para el erlotinib, una terapia biológica. Caso clínico: Varón de 62 años, con hábito tabáquico de alto riesgo oncológico, que debuta con un cuadro de cefalea de un mes de evolución, objetivándose por resonancia magnética tumor cerebral. El diagnóstico inmunohistoquímico post quirúrgico fue adenocarcinoma pulmonar metastásico (TTF-1 (+. La tomografía identificó una lesión en el lóbulo superior derecho del pulmón; no presentaba clínica respiratoria. Al ser positivo para la mutación en el exón 21 del gen EGFR, se inició terapia con erlotinib, siendo bien tolerada por el paciente y manteniendo su estabilidad clínica. El paciente sobrevivió por el lapso de 31 meses posterior a su diagnóstico. Discusión: El tratamiento con erlotinib fue inicialmente indicado en el perfil de una paciente mujer, asiática y no fumadora. La eficacia en los estudios en pacientes con cáncer de pulmón de células no pequeñas evidencia que la sobrevida global es 15,9 meses, muy por debajo del visto en el presente caso.

  17. Marine exotic isopods from the Iberian Peninsula and nearby waters.

    Science.gov (United States)

    Martínez-Laiz, Gemma; Ros, Macarena; Guerra-García, José M

    2018-01-01

    Effective management of marine bioinvasions starts with prevention, communication among the scientific community and comprehensive updated data on the distribution ranges of exotic species. Despite being a hotspot for introduction due to numerous shipping routes converging at the Strait of Gibraltar, knowledge of marine exotics in the Iberian Peninsula is scarce, especially of abundant but small-sized and taxonomically challenging taxa such as the Order Isopoda. To fill this gap, we conducted several sampling surveys in 44 marinas and provide the first comprehensive study of marine exotic isopods from the Iberian Peninsula, the southern side of the Strait of Gibraltar (northern Africa) and the Balearic Islands. Exotic species included Ianiropsis serricaudis (first record for the Iberian Peninsula and Lusitanian marine province), Paracerceis sculpta (first record for the Alboran Sea ecoregion), Paradella dianae , Paranthura japonica (earliest record for the Iberian Peninsula) and Sphaeroma walkeri . Photographs with morphological details for identification for non-taxonomic experts are provided, their worldwide distribution is updated and patterns of invasion are discussed. We report an expansion in the distribution range of all species, especially at the Strait of Gibraltar and nearby areas. Ianiropsis serricaudis and Paranthura japonica are polyvectic, with shellfish trade and recreational boating being most probable vectors for their introduction and secondary spread. The subsequent finding of the studied species in additional marinas over the years points at recreational boating as a vector and indicates a future spread. We call for attention to reduce lags in the detection and reporting of small-size exotics, which usually remain overlooked or underestimated until the invasion process is at an advanced stage.

  18. BioMagResBank database with sets of experimental NMR constraints corresponding to the structures of over 1400 biomolecules deposited in the Protein Data Bank

    International Nuclear Information System (INIS)

    Doreleijers, Jurgen F.; Mading, Steve; Maziuk, Dimitri; Sojourner, Kassandra; Yin Lei; Zhu Jun; Markley, John L.; Ulrich, Eldon L.

    2003-01-01

    Experimental constraints associated with NMR structures are available from the Protein Data Bank (PDB) in the form of 'Magnetic Resonance' (MR) files. These files contain multiple types of data concatenated without boundary markers and are difficult to use for further research. Reported here are the results of a project initiated to annotate, archive, and disseminate these data to the research community from a searchable resource in a uniform format. The MR files from a set of 1410 NMR structures were analyzed and their original constituent data blocks annotated as to data type using a semi-automated protocol. A new software program called Wattos was then used to parse and archive the data in a relational database. From the total number of MR file blocks annotated as constraints, it proved possible to parse 84% (3337/3975). The constraint lists that were parsed correspond to three data types (2511 distance, 788 dihedral angle, and 38 residual dipolar couplings lists) from the three most popular software packages used in NMR structure determination: XPLOR/CNS (2520 lists), DISCOVER (412 lists), and DYANA/DIANA (405 lists). These constraints were then mapped to a developmental version of the BioMagResBank (BMRB) data model. A total of 31 data types originating from 16 programs have been classified, with the NOE distance constraint being the most commonly observed. The results serve as a model for the development of standards for NMR constraint deposition in computer-readable form. The constraints are updated regularly and are available from the BMRB web site (http://www.bmrb.wisc.edu)

  19. Managing the pediatric patient with celiac disease: a multidisciplinary approach

    Directory of Open Access Journals (Sweden)

    Isaac DM

    2016-10-01

    Full Text Available Daniela Migliarese Isaac,1 Jessica Wu,2 Diana R Mager,3,4 Justine M Turner1 1Department of Pediatric Gastroenterology and Nutrition, Faculty of Medicine and Dentistry, University of Alberta; 2Alberta Health Services–Child Health Nutrition Services, Stollery Children’s Hospital; 3Department of Agriculture, Food and Nutritional Science; 4Department of Pediatrics, University of Alberta, Edmonton, AB, Canada Abstract: Celiac disease (CD is an autoimmune reaction to gluten, leading to intestinal inflammation, villous atrophy, and malabsorption. It is the most common autoimmune gastrointestinal disorder, with an increasing prevalence. A life-long gluten-free diet (GFD is an effective treatment to alleviate symptoms, normalize autoantibodies, and heal the intestinal mucosa in patients with CD. Poorly controlled CD poses a significant concern for ongoing malabsorption, growth restriction, and the long-term concern of intestinal lymphoma. Achieving GFD compliance and long-term disease control poses a challenge, with adolescents at particular risk for high rates of noncompliance. Attention has turned toward innovative management strategies to improve adherence and achieve better disease control. One such strategy is the development of multidisciplinary clinic approach, and CD is a complex life-long disease state that would benefit from a multifaceted team approach as recognized by multiple national and international bodies, including the National Institutes of Health. Utilizing the combined efforts of the pediatric gastroenterologist, registered dietitian, registered nurse, and primary care provider (general practitioner or general pediatrician in a CD multidisciplinary clinic model will be of benefit for patients and families in optimizing diagnosis, provision of GFD teaching, and long-term adherence to a GFD. This paper discusses the benefits and proposed structure for multidisciplinary care in improving management of CD. Keywords: celiac disease

  20. Eritema multiforme ampollar extenso asociado a infección por virus herpes simplex Extended Bullous Erythema Multiforme Associated To Herpes Simplex Virus Infection

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    A Elgueta-Noy

    2009-12-01

    Full Text Available El Eritema Multiforme (EM es una reacción cutánea aguda generalmente benigna y autolimitada, asociada a la infección por Virus Herpes Simplex (HSV. Se caracteriza por lesiones polimorfas y tipo diana en extremidades y mucosas. Presentamos un paciente de 22 años con pápulas, vesículas y ampollas, que evoluciona con un 90% de la superficie corporal comprometida en tres semanas. Se realizó una reacción de polimerasa en cadena para HSV, resultando positiva en una costra. La biopsia de piel y la tinción de inmunohistoquímica positiva para linfocitos T CD4, fueron compatibles con EM ampollar asociado a HSV. Destacamos la importancia de la correlación clínico patológica, apoyada por el estudio virológico, en el diagnóstico de este caso de presentación atípica. Los hallazgos de laboratorio confirmaron lo descrito en la literatura respecto de la patogenia del EM asociado a HSV.Erythema Multiforme (EM is a generally benign and self-limited acute cutaneous reaction, associated with Herpes Simplex Virus (HSV infection. It is characterized by polymorphic "target" lesions in extremities and mucosal tissues. We report a 22-year old patient with papules, vesicles and blisters, which evolved to cover 90% of the body in three weeks. We performed a PCR study for HSV, which was positive in a crust. A skin biopsy and positive immunohistochemical stain for LT CD4+ were compatible with bullous EM associated with HSV. We underline the importance of pathological clinical correlation, reinforced by a virological study, in the diagnosis of this case with atypical symptoms. The laboratory findings confirmed literature descriptions with respect to the pathogenicity of EM associated with HSV.

  1. The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach

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    Crisan D

    2015-09-01

    Full Text Available Diana Crisan,1 Iulia Roman,2 Maria Crisan,2 Karin Scharffetter-Kochanek,1 Radu Badea31Clinic of Dermatology and Allergology, University Clinic Ulm, Ulm, Germany; 2Clinic of Dermatology and Venereology, 3Department of Clinical Imaging Ultrasound, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaBackground: Imagistic methods stand as modern, non-invasive, and objective means of assessing the impact of topical cutaneous therapies.Objective: This study focuses on the evaluation, by high-frequency ultrasound, of the cutaneous changes induced by topical use of a vitamin C complex at facial level.Methods: A vitamin C-based solution/Placebo moisturizer cream was applied at facial level of 60 healthy female subjects according to a predetermined protocol. Ultrasonographic images (Dermascan C, 20 MHz were taken from zygomatic level initially, at 40 and 60 days after therapy. The following parameters were assessed for every subject: thickness of the epidermis and dermis (mm, the number of low (LEP, medium (MEP, high echogenic pixels (HEP, and the number of LEP in the upper dermis/lower dermis (LEPs/LEPi.Results: LEP decreased significantly in all age categories during and after therapy, but especially in the first 2 age intervals, up to the age of 50 (P=0.0001. MEP and HEP, pixel categories that quantify protein synthesis also had an age-dependent evolution in the study, increasing significantly in all age categories but most of all in the first age interval (P=0.002. Our ultrasonographic data suggest that collagen synthesis increased significantly after topical vitamin C therapy, and is responsible for the increase in MEP and HEP and consequent decrease of the LEP.Conclusion: Our study shows that topically applied vitamin C is highly efficient as a rejuvenation therapy, inducing significant collagen synthesis in all age groups with minimal side effects.Keywords: ascorbic acid, rejuvenation, ultrasound, collagen synthesis

  2. In silico prediction of microRNAs on fluoride induced sperm toxicity in mice.

    Science.gov (United States)

    Raghunath, Azhwar; Jeyabaskar, Dhivyalakshmi; Sundarraj, Kiruthika; Panneerselvam, Lakshmikanthan; Perumal, Ekambaram

    2016-12-01

    Fluorosis is an endemic global problem causing male reproductive impairment. F mediates male reproductive toxicity in mice down-regulating 63 genes involved in diverse biological processes - apoptosis, cell cycle, cell signaling, chemotaxis, electron transport, glycolysis, oxidative stress, sperm capacitation and spermatogenesis. We predicted the miRNAs down-regulating these 63 genes using TargetScan, DIANA and MicroCosm. The prediction tools identified 3059 miRNAs targeting 63 genes. Of the predicted interactions, 11 miRNAs (mmu-miR-103, -107, -122, -188a, -199a-5p, -205, -340-5p, -345-3p, -452-5p, -499, -878-3p) were commonly found in the three tools utilized and seven miRNAs (miR-9-5p, miR-511-3p, miR-7b-5p, miR-30e-5p, miR-17-5p, miR-122-5p and miR-541-5p) targeting six genes (Traf3, Rock2, Rgs8, Atp1b2, Cacna2d1 and Aldoa) were already validated experimentally in mice. The miRNA-mRNA network of the predicted miRNAs with its respective targets revealed the complex interaction within a biological process leading to sperm dysfunction on exposure to F. Our findings not only suggest that the predicted miRs furnish evidence, but also have the potential to serve as non-invasive biomarkers on F-induced sperm dysfunction. Our data contribute towards elucidating the function of miRNAs in the fluoride induced infertility. miRNA molecular pathways in F intoxication will open new avenues on the use of antagomirs in recovering fertility. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. New standards in hypertension and cardiovascular risk management: focus on telmisartan

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    Domenico Galzerano

    2010-03-01

    Full Text Available Domenico Galzerano1, Cristina Capogrosso4, Sara Di Michele2, Antonio Galzerano1, Paola Paparello1, Diana Lama3, Carlo Gaudio21Department of Cardiology, San Gennaro Hospital, Naples, Italy; 2Department of Heart and Great Vessels, A. Reale, La Sapienza University, Rome, Italy; 3V Division of Internal Medicine, II University, Naples, Italy; 4Cardiology Division, San Giovanni Bosco Hospital, Naples, ItalyAbstract: Blockade of the renin–angiotensin system is an important approach in managing high blood pressure, and has increasingly been shown to affect cardiovascular disease processes mediated by angiotensin II throughout the cardiovascular and renal continua. Telmisartan is an angiotensin II receptor blocker (ARB displaying unique pharmacologic properties, including a longer half life than any other ARB, that result in large and sustained reductions of blood pressure. In patients with mild-to-moderate hypertension, telmisartan has proved superior to other antihypertensive agents (valsartan, losartan, ramipril, perindopril, and atenolol in controlling blood pressure particularly towards the end of the dosing interval. There is also clinical evidence that telmisartan reduces left ventricular hypertrophy, reduces arterial stiffness and the recurrence of atrial fibrillation, and confers renoprotection. The ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial (ONTARGET® study has demonstrated that telmisartan has similar cardiovascular protective effects to ramipril in a large, high-risk patient population but was better tolerated. The powerful and sustained blood pressure control apparent in clinical trials, together with cardiovascular protection and tolerability demonstrated in ONTARGET® means that telmisartan may be a preferred option for patients with hypertension.Keywords: angiotensin II receptor blocker, cardiovascular disease, hypertension, renin–angiotensin system, telmisartan

  4. Psicofarmacología de la Psicosis: Elección del Fármaco, Adherencia al Tratamiento y Nuevos Horizontes

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    Adela Pérez Escudero

    2010-01-01

    Full Text Available Los autores presentan una actualización del tratamiento antipsicótico de la psicosis, centrándose en tres aspectos: la elección del fármaco antipsicótico, el problema de la adherencia y los tratamientos aún en fase de investigación. El antipsicótico a elegir en el tratamiento debe tener en cuenta tanto características individuales de cada paciente, preferencias, como características clínicas de la enfermedad. Se revisan las principales guías de tratamiento para hacer una buena elección del fármaco atendiendo al mecanismo de acción y perfil de efectos secundarios, respuesta clínica, fase de la enfermedad, pacientes resistentes, etc. Uno de los grandes problemas del tratamiento farmacológico en la psicosis es conseguir una buena tasa de adherencia al mismo, para ello se revisan las estrategias psicofarmacológicas, psicoterapéuticas y psicosociales que puedan favorecerla. La investigación actual se centra en la búsqueda de nuevos fármacos con características de atipicidad similar a los ya existentes (bloqueo de múltiples receptores, agonismo parcial dopaminérgico, fármacos atípicos ya conocidos con nuevas presentaciones, principalmente de acción retardada que puede favorecer la adherencia y nuevas dianas, especialmente la acción sobre la vía glutamatérgica.

  5. Nanoinformatics: a new area of research in nanomedicine

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    Maojo V

    2012-07-01

    Full Text Available Victor Maojo,1 Martin Fritts,2,3 Diana de la Iglesia,1 Raul E Cachau,4 Miguel Garcia-Remesal,1 Joyce A Mitchell,5 Casimir Kulikowski61Biomedical Informatics Group, Departamento de Inteligencia Artificial, Facultad de Informática, Universidad Politécnica de Madrid, Spain; 2SAIC-Frederick Inc, National Cancer Institute at Frederick, Frederick, Maryland, 3National Institute of Standards and Technology, Gaithersburg, Maryland, 4Advanced Biomedical Computing Center, National Cancer Institute, SAIC-Frederick Inc, Frederick, Maryland, 5Department of Biomedical Informatics, University of Utah, Utah, 6Department of Computer Science, Rutgers, The State University of New Jersey, New Jersey, USAAbstract: Over a decade ago, nanotechnologists began research on applications of nanomaterials for medicine. This research has revealed a wide range of different challenges, as well as many opportunities. Some of these challenges are strongly related to informatics issues, dealing, for instance, with the management and integration of heterogeneous information, defining nomenclatures, taxonomies and classifications for various types of nanomaterials, and research on new modeling and simulation techniques for nanoparticles. Nanoinformatics has recently emerged in the USA and Europe to address these issues. In this paper, we present a review of nanoinformatics, describing its origins, the problems it addresses, areas of interest, and examples of current research initiatives and informatics resources. We suggest that nanoinformatics could accelerate research and development in nanomedicine, as has occurred in the past in other fields. For instance, biomedical informatics served as a fundamental catalyst for the Human Genome Project, and other genomic and –omics projects, as well as the translational efforts that link resulting molecular-level research to clinical problems and findings.Keywords: biomedical informatics, nanomedicine, nanotoxicology, ontologies

  6. Mobile Phone Interventions for Sleep Disorders and Sleep Quality: Systematic Review.

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    Shin, Jong Cheol; Kim, Julia; Grigsby-Toussaint, Diana

    2017-09-07

    Although mobile health technologies have been developed for interventions to improve sleep disorders and sleep quality, evidence of their effectiveness remains limited. A systematic literature review was performed to determine the effectiveness of mobile technology interventions for improving sleep disorders and sleep quality. Four electronic databases (EBSCOhost, PubMed/Medline, Scopus, and Web of Science) were searched for articles on mobile technology and sleep interventions published between January 1983 and December 2016. Studies were eligible for inclusion if they met the following criteria: (1) written in English, (2) adequate details on study design, (3) focus on sleep intervention research, (4) sleep index measurement outcome provided, and (5) publication in peer-reviewed journals. An initial sample of 2679 English-language papers were retrieved from five electronic databases. After screening and review, 16 eligible studies were evaluated to examine the impact of mobile phone interventions on sleep disorders and sleep quality. These included one case study, three pre-post studies, and 12 randomized controlled trials. The studies were categorized as (1) conventional mobile phone support and (2) utilizing mobile phone apps. Based on the results of sleep outcome measurements, 88% (14/16) studies showed that mobile phone interventions have the capability to attenuate sleep disorders and to enhance sleep quality, regardless of intervention type. In addition, mobile phone intervention methods (either alternatively or as an auxiliary) provide better sleep solutions in comparison with other recognized treatments (eg, cognitive behavioral therapy for insomnia). We found evidence to support the use of mobile phone interventions to address sleep disorders and to improve sleep quality. Our findings suggest that mobile phone technologies can be effective for future sleep intervention research. ©Jong Cheol Shin, Julia Kim, Diana Grigsby-Toussaint. Originally published

  7. PARENTING AND ITS INFLUENCE ON CHILD BEHAVIOUR

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    Jiji Mary Antony

    2017-12-01

    Full Text Available BACKGROUND Parenting is the process of giving care to the young and preparing them to face the challenges of life. Diana Baumrind introduced the models of parenting, authoritative, authoritarian and permissive depending on the level of demandingness and responsiveness. Defective parenting is associated with problem behaviours in children. This study was undertaken to find out which parenting style is least associated with behavioural problems and what are the problems associated with the different parenting style. MATERIALS AND METHODS 46 children who were admitted with minor illness at the institute of Child Health, Kottayam from January 2017 to Oct 2017 were enrolled after getting informed consent and IRB clearance. Purposive sampling method were used for the study. Demographic data was entered into a proforma. The PSDQ and CBCL 1½ -5 questionnaire was given to mothers to assess the parenting style and behavioural problems in their children. Data was analysed with statistical tests. The t test, one way ANOVA, Pearson correlation coefficient and regression analyses were used for the analyses. RESULTS The parenting styles of the mothers and the behavioural problems seen in their children were studied in this research. There was no significant difference in behavioural problems between the different age group studied and there was no difference in problem behaviours between male children and female children. Authoritative parenting style was least associated with problem behaviour. Authoritarian parenting style is associated with internalizing problems and permissive parenting is associated with externalizing problems. CONCLUSION Since the behaviour problems tends to linger through adolescence and adulthood, parental education regarding the positive parenting style and interventions can be given from early childhood during routine child care and structured programs.

  8. Attitudes toward menopause in HIV-infected and at-risk women

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    Diana Hartel

    2008-09-01

    Full Text Available Diana Hartel1, Yungtai Lo1, Carolyn Bauer2, Nancy Budner1, Andrea A Howard1, Michelle Floris-Moore1, Julia H Arnsten1,2, Nanette Santoro3, Ellie E Schoenbaum1,2,31Departments of Epidemiology and Population Health, 2Medicine, and 3Obstetrics and Gynecology and Women’s Health, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USAObjective: To study attitudes toward menopause in women with or at risk of human immunodeficiency virus (HIV aged 35 to 60 in New York City, NY, USA.Design: Data were obtained at the baseline interview in a cohort study of menopause. Of 502 participating women, 92 were postmenopausal and 162 were perimenopausal.Results: Overall, 37.5% of women had a relatively favorable attitude toward menopause. African Americans had a 72% greater odds of a positive attitude (OR = 1.72, 95% CI 1.16–2.57 than all other groups after adjusting for covariates. Hispanic women had the least favorable view of menopause. Experience of >3 menopausal symptoms and negative life events—being a witness to a murder, and the death of a child—were significantly associated with negative attitudes towards menopause (OR = 0.62, 95% CI 0.42–0.93 and OR = 0.64, 95% CI 0.43–0.93, respectively. Depressive symptoms, street drug use, and having a domestic partner, which is significant in single variable analyses, did not remain independent predictors in multivariate results. HIV status, menopause status, and age at interview were not associated with menopause attitudes.Conclusions: HIV-infected, drug-using, low-income women showed generally unfavorable attitudes towards menopause. High stress life events coupled with a high prevalence of depressive symptoms indicate this population has special needs marked by the menopause transition into older age.Keywords: menopause, attitudes, HIV, street drug users

  9. Impacto de la vacunación contra Haemophilus influenzae tipo b en Cuba

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    Dickinson Félix O.

    2001-01-01

    Full Text Available Objetivo. Determinar el impacto de la vacunación de menores de 2 años en Cuba contra Haemophilus influenzae tipo b (Hib, principal agente causal de la meningitis bacteriana en ese país. Métodos. La disponibilidad de vacunas conjugadas eficaces contra Hib motivó la vacunación nacional en 1999 de niños menores de 2 años, que alcanzó una cobertura de 97%. El impacto se evaluó mediante el Sistema Nacional de Vigilancia de Meningoencefalitis Bacterianas (SNVMEB. Resultados. La eficacia global de la vacunación se estimó en 99% y la incidencia general de la meningoencefalitis por Hib disminuyó de 1,3 a 0,6 por 100 000 habitantes (46,1%, observándose la mayor reducción en niños menores de 5 años (56,1%. En los menores de 1 año se redujo 70,5% y en el resto de los grupos de menores de 5 años disminuyó entre 25,9 y 49,6%. En el grupo diana para la vacunación, la incidencia se redujo 61,1%; entre los niños de este grupo que contrajeron la meningoencefalitis por Hib, solamente 8 (24,2% estaban vacunados, 7 de ellos con una sola dosis, aplicada 1 mes antes de enfermar. Conclusiones. Se ha demostrado que la vacunación a gran escala de los niños menores de 2 años contra Hib en Cuba a través del SNVMEB ha logrado disminuir notablemente la incidencia de meningoencefalitis por Hib.

  10. Evaluación ambiental del río San Juan de Santiago de Cuba por exposición bioacumulativa a metales pesados Environmental evaluation of San Juan river in Santiago de Cuba due to bioaccumulative exposure to heavy metals

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    George Argota Pérez

    2012-08-01

    Full Text Available Se evaluó la salud ambiental del río San Juan de Santiago de Cuba, expuesto a metales pesados, mediante la utilización de la especie biorreguladora Gambusia punctata. Se analizaron 271 individuos adultos clasificados por sexo, para lo cual se escogieron los intervalos de clases de edades 2,1-3,0 y 3,1-4,0 cm, según la longitud total, respectivamente. La mezcla ácida aplicada estuvo compuesta por ácido perclórico - ácido sulfúrico; (7:1 ácido nítrico para determinar los niveles bioacumulados en hígado, branquias y cerebro como órganos diana. Los metales analizados: cobre, zinc, plomo y cadmio, se cuantificaron mediante espectrometría por plasma inductivamente acoplado con vista axial. Se hallaron diferencias significativas (pThe environmental health of San Juan river in Santiago de Cuba, exposed to heavy metals was evaluated by means of the bioregulatory species Gambusia punctata. Two hundred and seventy five adults were analyzed and classified by sex, for whom the intervals of age classes 2.1-3.0 and 3.1-4.0 cm were chosen, according to the total longitude, respectively. The applied acid mixture was composed by perchloric acid - sulphuric acid; (7:1 nitric acid to determine the bioaccumulated levels in liver, branchiae and brain as target organs. The analyzed metals: copper, zinc, lead and cadmium, were quantified by means of spectrometry by plasma inductively coupled with axial view. There were significant differences (p <0.05 in the bioaccumulated values between intervals and sexes. It was concluded that the levels of bioaccumulated heavy metals overcame the permissible values, so that they represent an environmental risk in the quality of those waters.

  11. Pricing products: juxtaposing affordability with quality appeal.

    Science.gov (United States)

    1984-01-01

    Choosing appropriate product prices is 1 of the most crucial steps in creating an effective contraceptive social marketing (CSM) sales campaign. The Social Marketing Forum conducted an informal survey of social marketing project managers, international contractors, and marketing consultants to determine how CSM programs cope with pricing problems and ways to circumvent some obstacles. According to Diana Altman, a family planning consultant, low prices that make products available to needy individuals are more important than the program's self sufficiency, yet if prices are too low, consumers think the products were unusable in the US and thus were dumped on local markets. Other key factors include commercial competition, spiraling inflation rates, and problems with rising prices and retailer/distributor margins. A sampling of per capita gross national products indicates the poverty level of most CSM projects' target market. Consequently, CSM projects must set low pices, regardless of program operating costs. The goal often is to increase the demand and availability for contraceptives. The fact that social marketing products must pass through retail networks to reach consumers complicates the pricing equation. To deal with the problem, India's Nirodh program gives a 25% margin to distributors/wholesalers, compared to 6% offered on most other goods. Retailers also receive a 25% margin, more than double the commercial rate. Once prices are set, increases pose hazards. Local government approval often is a prerequisite and can require lengthy negotiations. Market studies remain a valuable approach to effective pricing, according to PNA's Mallamad and other research consultants. They cite such effective research strategies as test marketing products and asking consumers how prices affect buying habits. Further, CSM projects can jump over some pricing hurdles through creative marketing. An effective pricing strategy alone cannot produce a successful CSM program. Pricing

  12. Epilepsy and homicide

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    Pandya NS

    2013-05-01

    Full Text Available Neil S Pandya,1 Mirna Vrbancic,2 Lady Diana Ladino,3,4 José F Téllez-Zenteno31Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; 2Department of Clinical Health Psychology, Royal University Hospital, Saskatoon, Saskatchewan, Canada; 3Division of Neurology, Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; 4Department of Neurology, College of Medicine, University of Antioquia, Medellin, ColombiaPurpose: We report the rare case of a patient with intractable epilepsy and escalating aggression, resulting in murder, who had complete resolution of her seizures and explosive behavior following a right temporal lobectomy.Patients and methods: We searched the available literature from 1880 to 2013 for cases of epilepsy being used as a court defense for murder and collected information regarding the final sentencing outcomes. We selected 15 papers with a total of 50 homicides.Results: We describe the case of a 47-year-old woman with drug-resistant right temporal epilepsy who developed increasing emotional lability, outbursts of anger and escalating violent behavior culminating in a violent murder. The patient was imprisoned while awaiting trial. In the interim, she underwent a successful temporal lobectomy with full resolution of seizures, interictal rage and aggressive behaviors. After the surgery, her charges were downgraded and she was transferred to a psychiatric facility.Conclusion: The aggressive behavior associated with epilepsy has been described in the literature for over a century. A link between epilepsy and aggression has been disproportionally emphasized. These patients share some common characteristics: they are usually young men with a long history of epilepsy and lower than average intelligence. The violent act is postictal, sudden-onset, more likely to occur after a cluster of seizures and is usually related with alcohol abuse.Keywords: aggression, crime, epilepsy

  13. An antiaging skin care system containing alpha hydroxy acids and vitamins improves the biomechanical parameters of facial skin

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    Tran D

    2014-12-01

    Full Text Available Diana Tran, Joshua P Townley, Tanya M Barnes, Kerryn A Greive Ego Pharmaceuticals, Braeside, Victoria, Australia Background: The demand for antiaging products has dramatically increased in recent years, driven by an aging population seeking to maintain the appearance of youth. This study investigates the effects of an antiaging skin care system containing alpha hydroxy acids (AHAs in conjunction with vitamins B3, C, and E on the biomechanical parameters of facial skin. Methods: Fifty two volunteers followed an antiaging skin care regimen comprising of cleanser, eye cream, day moisturizer, and night moisturizer for 21 days. Wrinkle depth (Ry and skin roughness (Ra were measured by skin surface profilometry of the crow's feet area, and skin elasticity parameters R2 (gross elasticity, R5 (net elasticity, R6 (viscoelastic portion, and R7 (recovery after deformation were determined for facial skin by cutometer, preapplication and after 7, 14, and 21 days. Volunteers also completed a self-assessment questionnaire. Results: Compared to baseline, Ry and Ra significantly improved by 32.5% (P<0.0001 and 42.9% (P<0.0001, respectively, after 21 days of antiaging skin care treatment. These results were observed by the volunteers with 9 out of 10 discerning an improvement in skin texture and smoothness. Compared to baseline, R2 and R5 significantly increased by 15.2% (P<0.0001 and 12.5% (P=0.0449, respectively, while R6 significantly decreased by 17.7% (P<0.0001 after 21 days. R7 increased by 9.7% after 21 days compared to baseline but this was not significant over this time period. Conclusion: An antiaging skin care system containing AHAs and vitamins significantly improves the biomechanical parameters of the skin including wrinkles and skin texture, as well as elasticity without significant adverse effects. Keywords: alpha hydroxy acids, antiaging, nicotinamide, vitamin C, vitamin E, profilometry, cutometer

  14. Beyond offshoring: assess your company's global potential.

    Science.gov (United States)

    Farrell, Diana

    2004-12-01

    In the past few years, companies have become aware that they can slash costs by offshoring: moving jobs to lower-wage locations. But this practice is just the tip of the iceberg in terms of how globalization can transform industries, according to research by the McKinsey Global Institute (MGI). The institute's yearlong study suggests that by streamlining their production processes and supply chains globally, rather than just nationally or regionally, companies can lower their costs-as we've seen in the consumer-electronics and PC industries. Companies can save as much as 70% of their total costs through globalization--50% from offshoring, 5% from training and business-task redesign, and 15% from process improvements. But they don't have to stop there. The cost reductions make it possible to lower prices and expand into new markets, attracting whole new classes of customers. To date, however, few businesses have recognized the full scope of performance improvements that globalization makes possible, much less developed sound strategies for capturing those opportunities. In this article, Diana Farrell, director of MGI, offers a step-by-step approach to doing both things. Among her suggestions: Assess where your industry falls along the globalization spectrum, because not all sectors of the economy face the same challenges and opportunities at the same time. Also, pay attention to production, regulatory, and organizational barriers to globalization. If any of these can be changed, size up the cost-saving (and revenue-generating) opportunities that will emerge for your company as a result of those changes. Farrell also defines the five stages of globalization-market entry, product specialization, value chain disaggregation, value chain reengineering, and the creation of new markets-and notes the different levers for cutting costs and creating value that companies can use in each phase.

  15. Dehydration triggers differential microRNA expression in Xenopus laevis brain.

    Science.gov (United States)

    Luu, Bryan E; Storey, Kenneth B

    2015-11-15

    African clawed frogs, Xenopus laevis, although primarily aquatic, have a high tolerance for dehydration, being capable of withstanding the loss of up to 32-35% of total water body water. Recent studies have shown that microRNAs play a role in the response to dehydration by the liver, kidney and ventral skin of X. laevis. MicroRNAs act by modulating the expression of mRNA transcripts, thereby affecting diverse biochemical pathways. In this study, 43 microRNAs were assessed in frog brains comparing control and dehydrated (31.2±0.83% of total body water lost) conditions. MicroRNAs of interest were measured using a modified protocol which employs polyadenylation of microRNAs prior to reverse transcription and qPCR. Twelve microRNAs that showed a significant decrease in expression (to 41-77% of control levels) in brains from dehydrated frogs (xla-miR-15a, -150, -181a, -191, -211, -218, -219b, -30c, -30e, -31, -34a, and -34b) were identified. Genomic analysis showed that the sequences of these dehydration-responsive microRNAs were highly conserved as compared with the comparable microRNAs of mice (91-100%). Suppression of these microRNAs implies that translation of the mRNA transcripts under their control could be enhanced in response to dehydration. Bioinformatic analysis using the DIANA miRPath program (v.2.0) predicted the top two KEGG pathways that these microRNAs collectively regulate: 1. Axon guidance, and 2. Long-term potentiation. Previous studies indicated that suppression of these microRNAs promotes neuroprotective pathways by increasing the expression of brain-derived neurotrophic factor and activating anti-apoptotic pathways. This suggests that similar actions may be triggered in X. laevis brains as a protective response to dehydration. Crown Copyright © 2015. Published by Elsevier B.V. All rights reserved.

  16. In Silico Prediction and Validation of Gfap as an miR-3099 Target in Mouse Brain.

    Science.gov (United States)

    Abidin, Shahidee Zainal; Leong, Jia-Wen; Mahmoudi, Marzieh; Nordin, Norshariza; Abdullah, Syahril; Cheah, Pike-See; Ling, King-Hwa

    2017-08-01

    MicroRNAs are small non-coding RNAs that play crucial roles in the regulation of gene expression and protein synthesis during brain development. MiR-3099 is highly expressed throughout embryogenesis, especially in the developing central nervous system. Moreover, miR-3099 is also expressed at a higher level in differentiating neurons in vitro, suggesting that it is a potential regulator during neuronal cell development. This study aimed to predict the target genes of miR-3099 via in-silico analysis using four independent prediction algorithms (miRDB, miRanda, TargetScan, and DIANA-micro-T-CDS) with emphasis on target genes related to brain development and function. Based on the analysis, a total of 3,174 miR-3099 target genes were predicted. Those predicted by at least three algorithms (324 genes) were subjected to DAVID bioinformatics analysis to understand their overall functional themes and representation. The analysis revealed that nearly 70% of the target genes were expressed in the nervous system and a significant proportion were associated with transcriptional regulation and protein ubiquitination mechanisms. Comparison of in situ hybridization (ISH) expression patterns of miR-3099 in both published and in-house-generated ISH sections with the ISH sections of target genes from the Allen Brain Atlas identified 7 target genes (Dnmt3a, Gabpa, Gfap, Itga4, Lxn, Smad7, and Tbx18) having expression patterns complementary to miR-3099 in the developing and adult mouse brain samples. Of these, we validated Gfap as a direct downstream target of miR-3099 using the luciferase reporter gene system. In conclusion, we report the successful prediction and validation of Gfap as an miR-3099 target gene using a combination of bioinformatics resources with enrichment of annotations based on functional ontologies and a spatio-temporal expression dataset.

  17. Hypertensive crisis: urgency and hypertensive emergency

    Directory of Open Access Journals (Sweden)

    Javier Sobrino Martínez

    2016-12-01

    Full Text Available Resumen Las crisis hipertensivas son un conjunto de situaciones clínicas de variada gravedad y pronóstico. Las diferencias entre urgencias y emergencias hipertensivas radican en la existencia o no de riesgo vital por afectación de órganos diana, más que por los niveles de presión arterial. Las urgencias hipertensivas no suelen comportar riesgo vital inmediato por lo que el tratamiento puede iniciarse, incluso completarse, en el medio extrahospitalario. Las emergencias hipertensivas son situaciones clínicas muy graves que requieren asistencia hospitalaria. Ante un paciente con hipertensión grave, asintomático o con síntomas inespecíficos debe adoptarse una actitud terapéutica prudente. La primera medida será comprobar las cifras de presión arterial con tomas repetidas de la misma y tratar los posibles factores desencadenantes. El objetivo del tratamiento de las urgencias hipertensivas es tanto obtener una reducción de las cifras de presión arterial (al menos un 20% de las cifras basales como evitar reducciones bruscas y/o excesivas de la misma. En las urgencias hipertensivas no deberían utilizarse fármacos de acción rápida por el riesgo de accidentes isquémicos y utilizar fármacos con vida media más larga. El riesgo cardiovascular de estos pacientes es superior al de los hipertensos que no sufren una crisis hipertensiva. En las emergencias hipertensivas la elección del fármaco deberá individualizarse. La vía parenteral es la forma habitual de la administración de fármacos.

  18. Ranking of microRNA target prediction scores by Pareto front analysis.

    Science.gov (United States)

    Sahoo, Sudhakar; Albrecht, Andreas A

    2010-12-01

    Over the past ten years, a variety of microRNA target prediction methods has been developed, and many of the methods are constantly improved and adapted to recent insights into miRNA-mRNA interactions. In a typical scenario, different methods return different rankings of putative targets, even if the ranking is reduced to selected mRNAs that are related to a specific disease or cell type. For the experimental validation it is then difficult to decide in which order to process the predicted miRNA-mRNA bindings, since each validation is a laborious task and therefore only a limited number of mRNAs can be analysed. We propose a new ranking scheme that combines ranked predictions from several methods and - unlike standard thresholding methods - utilises the concept of Pareto fronts as defined in multi-objective optimisation. In the present study, we attempt a proof of concept by applying the new ranking scheme to hsa-miR-21, hsa-miR-125b, and hsa-miR-373 and prediction scores supplied by PITA and RNAhybrid. The scores are interpreted as a two-objective optimisation problem, and the elements of the Pareto front are ranked by the STarMir score with a subsequent re-calculation of the Pareto front after removal of the top-ranked mRNA from the basic set of prediction scores. The method is evaluated on validated targets of the three miRNA, and the ranking is compared to scores from DIANA-microT and TargetScan. We observed that the new ranking method performs well and consistent, and the first validated targets are elements of Pareto fronts at a relatively early stage of the recurrent procedure, which encourages further research towards a higher-dimensional analysis of Pareto fronts. Copyright © 2010 Elsevier Ltd. All rights reserved.

  19. METODOLOGÍA Y LOGÍSTICA DE CAMPO DE UN ESTUDIO MULTINIVEL SOBRE LA INFLUENCIA EN ESPAÑA DE LAS CARACTERÍSTICAS MEDIOAMBIENTALES EN LA SALUD MENTAL DE POBLACIÓN AUTÓCTONA Y ECUATORIANA INMIGRANTE

    Directory of Open Access Journals (Sweden)

    Débora Álvarez-del Arco

    2009-01-01

    Full Text Available Se realizó una investigación multinivel sobre el impacto de las características ambientales de la zona de residencia en la salud mental de población autóctona e inmigrante. El objetivo de este artículo es describir el planteamiento metodológico de la investigación, el trabajo de campo, las tasas de respuesta correspondientes y discutir el diseño metodológico y las dificultades derivadas de su puesta en práctica. Los datos individuales se obtuvieron aplicando un cuestionario estructurado de aproximadamente 40 minutos, mediante entrevista domiciliaria a personas españolas y ecuatorianas de 18 a 55 años. El trabajo se realizó de septiembre de 2006 a enero de 2007 en una muestra estimada de 1.186 personas equiparada por sexo y nacionalidad, obtenida aleatoriamente de los Padrones Municipales de 33 áreas (municipios o barrios de Madrid, Alicante, Almería y Murcia, seleccionadas según criterios de densidad étnica y socioeconómicos. Previamente se realizó un estudio piloto (n=113Los indicadores sociodemográficos de las áreas se obtuvieron a partir de fuentes secundarias. Se entrevistó a 1.144 personas (96%. La tasa de respuesta global fue del 61%, superior entre ecuatorianos (69%, colectivo que presentó más problemas de localización (34%. Las negativas a colaborar fueron más altas entre españoles (21%. Se concluye que en este tipo de estudios sería conveniente revisar las estrategias de muestreo para combinar criterios de eficiencia con la necesidad de obtener una muestra representativa de la población diana. Se constata la dificultad de obtener datos inframunicipales de integración social.

  20. International survey to assess women's attitudes regarding choice of daily versus nondaily female hormonal contraception

    Directory of Open Access Journals (Sweden)

    Mansour D

    2014-04-01

    Full Text Available Diana Mansour New Croft Centre, Newcastle Hospitals Community Health, Newcastle upon Tyne, UK Background: The availability of reliable contraception tailored to suit women's needs and lifestyles is an essential step in addressing unintended pregnancy and its substantial human and financial costs. The daily combined oral contraceptive pill has been the short-acting hormonal contraceptive of choice for the last 50 years. However, for some women, this may be neither suitable nor optimal. Methods: Here we report the findings of a large, online, questionnaire-based study conducted in Brazil, France, Germany, Italy, and the USA. The study was designed to assess women's attitudes, beliefs, and unmet needs regarding current hormonal contraceptive options via an anonymous online survey. Women eligible for contraception were required to respond to questions using either a binary (yes/no or seven-point scale (1, complete disagreement; 7, complete agreement. Women were also asked about other relevant issues, such as lifestyle, perception of menstruation and pregnancy, level of education, and relationship with their health care professional. Results: In total, 12,094 women were questioned, of whom 68% required contraception. Overall, 28% of women expressed an interest in novel contraceptive products, and 49% stated that they would prefer a nondaily method. Although many women expressed satisfaction with the pill, daily intake was thought to be burdensome, resulting in irregular and ineffective usage. However, many women continued to choose the pill due to lack of consideration of and education about other options. Approximately half of the women wished to conceive in the near future. Conclusion: The findings indicate that nearly half of respondents would prefer a nondaily form of contraception. Furthermore, approximately half of respondents wished to conceive in the near future, suggesting that they are unlikely to favor long-acting options. Effective

  1. A review of the neural and behavioral consequences for unitizing emotional and neutral information

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    Brendan eMurray

    2013-05-01

    Full Text Available A special type of association, called a unitization, is formed when pieces of information are encoded as a single representation in memory (e.g., shirt and blue are encoded as a blue shirt; Graf & Schacter, 1989 and typically are later reactivated in memory as a single unit, allowing access to the features of multiple related stimuli at once (Bader et al., 2010; Diana et al., 2011. This review examines the neural processes supporting memory for unitizations and how the emotional content of the material may influence unitization. Although associative binding is typically reliant on hippocampal processes and supported by recollection, the first part of this review will present evidence to suggest that when two items are unitized into a single representation, memory for those bound items may be accomplished on the basis of familiarity and without reliance on the hippocampus. The second part of this review discusses how emotion may affect the processes that give rise to unitizations. Emotional information typically receives a mnemonic benefit over neutral information, but the literature is mixed on whether the presence of emotional information impedes or enhances the associative binding of neutral information (reviewed by Mather, 2007. It has been suggested that the way the emotional and neutral details are related together may be critical to whether the neutral details are enhanced or impeded (Mather, 2007; Mather & Sutherland, 2011. We focus on whether emotional arousal aides or inhibits the creation of a unitized representation, presenting preliminary data and future directions to test empirically the effects of forming and retrieving emotional and neutral unitizations.

  2. Protocolo de actuación frente a situaciones conflictivas con los ciudadanos en centros de atención primaria Action protocol against conflictive situations with citizens in primary care centres

    Directory of Open Access Journals (Sweden)

    Coral Sainz Pinós

    2011-03-01

    Full Text Available Según la Organización Internacional de Trabajo (OIT, el 25% de la violencia en el trabajo se produce en el sector sanitario, debido al estrecho contacto con usuarios. Por este motivo, mediante la elaboración de un protocolo y en cumplimiento de la Orden 212/2004, de 4 de Marzo, del Consejero de Sanidad y Consumo, el presente artículo pretende establecer las pautas de actuación que deben llevar a cabo el trabajador, su mando y el resto de instancias implicadas de un centro de atención primaria, ante una situación conflictiva con los ciudadanos (pacientes, familiares y acompañantes de los mismos, en el que medie cualquier tipo de agresión verbal, física o psíquica. La población diana de este protocolo son el trabajador expuesto y todos los usuarios del sistema sanitario. Con esto, se pretende mejorar las condiciones de seguridad y salud de los trabajadores del ámbito sanitario.According to the International Labour Organization (ILO, 25% of workplace violence occurs in the health sector, due to close contact with customers. By developing a protocol and in compliance with the Order 212/2004, 4 March , Health Advisor, this article aims to establish guidelines for action to be carried out by the worker, his boss and all other employees involved in a conflictive situation in a primary care center when in contact with citizens (patients, family members , in which there is any type of verbal, physical or mental aggression. The target population of this protocol are exposed workers and all users of the health system. This protocol aims to improve safety and health conditions in health sector workers.

  3. Creencias adolescentes sobre la violencia de género. Sexismo en las relaciones entre adolescentes

    Directory of Open Access Journals (Sweden)

    Zoraida de la Osa Escudero

    2013-12-01

    Full Text Available El presente trabajo indaga en las relaciones de pareja en la adolescencia, analizando las creencias de los y las adolescentes atendiendo al factor violencia de género desde una perspectiva cognitivo-evolutiva. La muestra está compuesta por 297 estudiantes con edades comprendidas entre los 13 y 18 años (2º ESO, 4º ESO y 2º Bachillerato de tres centros privados-concertados de Madrid. Analizamos sus representaciones de las relaciones de pareja desde el punto de vista de ambos géneros y su grado de acuerdo con la justificación de violencia. El estudio responde a un diseño transversal (cuasi-experimental con encuesta. El instrumento utilizado es una adaptación del Cuestionario de Actitudes hacia la Diversidad y la Violencia (CADV. Los resultados muestran una correspondencia parcial en la relación entre el desarrollo evolutivo-moral y el grado de justificación de diferentes situaciones en las que se presenta la violencia. De acuerdo con nuestros datos, el acuerdo con creencias sexistas y justificación de la violencia desciende según se avanza en la escolarización. Al mismo tiempo, obtenemos que es en el tramo de edad de quince a dieciséis años (4º ESO donde justifican más los estereotipos de género. Todo ello nos lleva a señalar la adolescencia media como curso diana en el que realizar una intervención psicoeducativa considerando los valores relacionados con la igualdad y el respeto entre los géneros

  4. Common features of microRNA target prediction tools

    Directory of Open Access Journals (Sweden)

    Sarah M. Peterson

    2014-02-01

    Full Text Available The human genome encodes for over 1800 microRNAs, which are short noncoding RNA molecules that function to regulate gene expression post-transcriptionally. Due to the potential for one microRNA to target multiple gene transcripts, microRNAs are recognized as a major mechanism to regulate gene expression and mRNA translation. Computational prediction of microRNA targets is a critical initial step in identifying microRNA:mRNA target interactions for experimental validation. The available tools for microRNA target prediction encompass a range of different computational approaches, from the modeling of physical interactions to the incorporation of machine learning. This review provides an overview of the major computational approaches to microRNA target prediction. Our discussion highlights three tools for their ease of use, reliance on relatively updated versions of miRBase, and range of capabilities, and these are DIANA-microT-CDS, miRanda-mirSVR, and TargetScan. In comparison across all microRNA target prediction tools, four main aspects of the microRNA:mRNA target interaction emerge as common features on which most target prediction is based: seed match, conservation, free energy, and site accessibility. This review explains these features and identifies how they are incorporated into currently available target prediction tools. MicroRNA target prediction is a dynamic field with increasing attention on development of new analysis tools. This review attempts to provide a comprehensive assessment of these tools in a manner that is accessible across disciplines. Understanding the basis of these prediction methodologies will aid in user selection of the appropriate tools and interpretation of the tool output.

  5. New procedure to synthesize silver nanoparticles and their interaction with local anesthetics

    Directory of Open Access Journals (Sweden)

    Mocanu A

    2013-10-01

    Full Text Available Aurora Mocanu,1 Roxana Diana Pasca,1 Gheorghe Tomoaia,2 Corina Garbo,1 Petre T Frangopol,1 Ossi Horovitz,1 Maria Tomoaia-Cotisel11Chemical Engineering Department, Babes-Bolyai University, 2Orthopedic Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaAbstract: Silver nanoparticles (AgNPs were prepared in aqueous colloid dispersions by the reduction of Ag+ with glucose in alkaline medium. Tetraethyl orthosilicate and l-asparagine were added as stabilizers of NPs. The AgNPs were characterized, and their interaction with three local anesthetics (procaine, dibucaine, or tetracaine was investigated. Optical spectra show the characteristic absorption band of AgNPs, due to surface plasmon resonance. Modifications in the position and shape of this band reflect the self-assembly of metal NPs mediated by anesthetic molecules and the progress in time of the aggregation process. Zeta-potential measuring was applied in order to characterize the electrostatic stability of the NPs. The size and shape of the AgNPs, as well as the features of the assemblies formed by their association in the presence of anesthetics, were evidenced by transmission electron microscopy images. Atomic force microscopy images showed the characteristics of the films of AgNPs deposited on glass support. The effect of the anesthetics could be described in terms of electrostatic forces between the negatively charged AgNPs and the anesthetic molecules, existing also in their cationic form at the working pH. But also hydrophobic and hydrogen bonding interactions between the coated nanoparticles and anesthetics molecular species should be considered.Keywords: self-assembled nanostructures, UV-vis spectra, TEM, AFM, zeta potential

  6. Solution structure of human intestinal fatty acid binding protein: Implications for ligand entry and exit

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Fengli [Boston University School of Medicine, Department of Biophysics (United States); Luecke, Christian [Johann Wolfgang Goethe-Universitaet (Germany); Baier, Leslie J. [NIDDK, NIH, Phoenix Epidemiology and Clinical Research Branch (United States); Sacchettini, James C. [Texas A and M University, Department of Biochemistry and Biophysics (United States); Hamilton, James A. [Boston University School of Medicine, Department of Biophysics (United States)

    1997-04-15

    The human intestinal fatty acid binding protein (I-FABP) is a small (131 amino acids) protein which binds dietary long-chain fatty acids in the cytosol of enterocytes. Recently, an alanine to threonine substitution at position 54 in I-FABP has been identified which affects fatty acid binding and transport, and is associated with the development of insulin resistance in several populations including Mexican-Americans and Pima Indians. To investigate the molecular basis of the binding properties of I-FABP, the 3D solution structure of the more common form of human I-FABP (Ala54) was studied by multidimensional NMR spectroscopy.Recombinant I-FABP was expressed from E. coli in the presence and absence of 15N-enriched media. The sequential assignments for non-delipidated I-FABP were completed by using 2D homonuclear spectra (COSY, TOCSY and NOESY) and 3D heteronuclear spectra(NOESY-HMQC and TOCSY-HMQC). The tertiary structure of human I-FABP was calculated by using the distance geometry program DIANA based on 2519 distance constraints obtained from the NMR data. Subsequent energy minimization was carried out by using the program SYBYL in the presence of distance constraints. The conformation of human I-FABP consists of 10 antiparallel {beta}-strands which form two nearly orthogonal {beta}-sheets of five strands each, and two short {alpha}-helices that connect the {beta}-strands A and B. The interior of the protein consists of a water-filled cavity between the two {beta}-sheets. The NMR solution structure of human I-FABP is similar to the crystal structure of rat I-FABP.The NMR results show significant conformational variability of certain backbone segments around the postulated portal region for the entry and exit of fatty acid ligand.

  7. Fisiología trabecular y glaucoma de ángulo abierto Trabecular physiology and open angle glaucoma

    Directory of Open Access Journals (Sweden)

    Yoanner Martín Perera

    2012-01-01

    Full Text Available El glaucoma constituye una de las enfermedades oculares más frecuentes en el mundo. Su etiología es variada, pero el problema radica generalmente en la evacuación del humor acuoso a nivel de la red trabecular y del canal de Schlemm. Se realizó una revisión bibliográfica sobre los principales mecanismos envueltos en la función trabecular: capacidad fagocítica de las células trabeculares, regulación de la composición de la matriz extracelular, contracción-relajación de las células trabeculares y los cambios en su volumen y forma. Un mayor conocimiento de la fisiología trabecular y su relación con la fisiopatología del glaucoma permitirá un mejor manejo de la enfermedad, así como el desarrollo de nuevos fármacos que tengan como diana la vía trabecular de manera selectiva y que permitan evitar los efectos secundarios relacionados con el empleo de medicamentos poco específicos.Glaucoma is one of the most common eye diseases worldwide, but usually the problem lies in the evacuation of aqueous humor at the trabecular meshwork and Schlemm's canal. A literature review was made about the main mechanisms involved in the trabecular function: the phagocytic capacity of trabecular cells, the regulation of the extracellular matrix composition, the contraction-relaxation of trabecular cells and the changes in their volume and shape. A better understanding of the trabecular physiology and the pathophysiology of glaucoma will allow better disease management and development of new drugs that have as their target the trabecular pathway in a selective way and that avoid the side effects associated with the use of nonspecific drugs.

  8. ENVEJECIENDO EN RECLUSIÓN: UN ESTUDIO DE CASO DE LOS ADULTOS MAYORES MEXIQUENSES EN SITUACIÓN DE CÁRCEL

    Directory of Open Access Journals (Sweden)

    Telésforo Ramírez García*

    2010-03-01

    Full Text Available El envejecimiento demográfico es un tema que ha sido analizado desde diferentes perspectivas teóricas y metodológicas. Este trabajo presenta un estudio de corte cualitativo sobre el envejecimiento de la población mexiquense en situación de cárcel, resultado de entrevistas en profundidad realizadas a adultos mayores, entre los meses de mayo y julio de 2008, en el penal de Santiaguito o Almoloyita, en el Estado de México. El texto propone una discusión sobre la perspectiva de las instituciones a partir del análisis de las condiciones de vida y del proceso de envejecimiento de los residentes en la cárcel, con la finalidad de conocer sus prácticas, interpretar sus tiempos vividos, y comprender de qué manera esos viejos piensan sus experiencias y su vejez en el vivir cotidiano penitenciario. Palabras claves: Adultos mayores; cárcel; envejecimiento de la población; México. * Agradezco a Ana Lilia Salazar y a Diana Aguilar por su apoyo en la elaboración y transcripción de las entrevistas realizadas en el penal de Santiaguito, en la ciudad de Toluca, Estado de México. Igualmente, mis agradecimientos van dirigidos a la Dra. Verónica Montes de Oca, quien con sus acertados comentarios ayudo mejorar la última versión del documento. Éste artículo fue realizado durante los meses de julio-septiembre de 2008, como parte de las actividades académicas desarrolladas en el Centro de Investigaciones y Estudios Avanzados de la Población (CIEAP, de la Universidad Autónoma del Estado de México (UAEM.

  9. On the seismic behavior of the main tower of the San Felice sul Panaro (Italy) fortress

    Science.gov (United States)

    Castellazzi, Giovanni; D'Altri, Antonio Maria; de Miranda, Stefano; Magagnini, Stefano; Tralli, Antonio

    2016-12-01

    The medieval fortresses are a very common and distinctive type among the Emilian historical constructions and the earthquakes of May 20th and 29th, 2012 underlined their high vulnerability. Among those heavily damaged, there is the fortress of San Felice sul Panaro located between the two epicenters. This study presents some FE results regarding the behavior under seismic actions of the main tower (Mastio tower). The Mastio has peculiar geometric features and represents a typical example of non-isolated tower. In fact, it is constrained in very different ways by the surrounding parts of the fortress along two of its sides: on the north side it is constrained by the perimeter wall until one third of his high, while a stiffer building constrains it on the west side. In order to remodel the entire fortress, a multidisciplinary project involving the Municipality of San Felice sul Panaro and four Universities of the Emilia- Romagna (Bologna, Ferrara, Parma and Modena) together with the University of Genoa is going on. The study, oriented to the structural restoration, produced an accurate survey of the entire building including a fine definition of architectural peculiarities, historical stages and materials evolution. Based on such geometrical data, we developed a detailed 3D realistic mesh, with a point-by-point characterization of each single geometric element. We performed both pushover and nonlinear dynamic analyses using accelerograms data measured near the fortress on May 29th. A damage-plasticity material model exhibiting softening in both tension and compression, already available in the commercial code Abaqus, has been used for masonry in nonlinear dynamic analyses. On the other hand, pushover analyses have been performed utilizing similar constitutive equations available on code DIANA. The effects of higher modes of vibration have been taken into account by means of the modal pushover analysis technique. For the sake of conciseness, only some preliminary

  10. Dental Blogs, Podcasts, and Associated Social Media: Descriptive Mapping and Analysis.

    Science.gov (United States)

    Melkers, Julia; Hicks, Diana; Rosenblum, Simone; Isett, Kimberley R; Elliott, Jacqueline

    2017-07-26

    Studies of social media in both medicine and dentistry have largely focused on the value of social media for marketing to and communicating with patients and for clinical education. There is limited evidence of how dental clinicians contribute to and use social media to disseminate and access information relevant to clinical care. The purpose of this study was to inventory and assess the entry, growth, sources, and content of clinically relevant social media in dentistry. We developed an inventory of blogs, podcasts, videos, and associated social media disseminating clinical information to dentists. We assessed hosts' media activity in terms of their combinations of modalities, entry and exit dates, frequency of posting, types of content posted, and size of audience. Our study showed that clinically relevant information is posted by dentists and hygienists on social media. Clinically relevant information was provided in 89 blogs and podcasts, and topic analysis showed motives for blogging by host type: 55% (49 hosts) were practicing dentists or hygienists, followed by consultants (27 hosts, 30%), media including publishers and discussion board hosts (8 hosts, 9%), and professional organizations and corporations. We demonstrated the participation of and potential for practicing dentists and hygienists to use social media to share clinical and other information with practicing colleagues. There is a clear audience for these social media sites, suggesting a changing mode of information diffusion in dentistry. This study was a first effort to fill the gap in understanding the nature and potential role of social media in clinical dentistry. ©Julia Melkers, Diana Hicks, Simone Rosenblum, Kimberley R Isett, Jacqueline Elliott. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 26.07.2017.

  11. Effect of spatial nonuniformity of heating on compression and burning of a thermonuclear target under direct multibeam irradiation by a megajoule laser pulse

    Energy Technology Data Exchange (ETDEWEB)

    Bel’kov, S. A.; Bondarenko, S. V. [Russian Federal Nuclear Center, All-Russia Research Institute of Experimental Physics (Russian Federation); Vergunova, G. A. [Russian Academy of Sciences, Lebedev Physical Institute (Russian Federation); Garanin, S. G. [Russian Federal Nuclear Center, All-Russia Research Institute of Experimental Physics (Russian Federation); Gus’kov, S. Yu.; Demchenko, N. N.; Doskoch, I. Ya. [Russian Academy of Sciences, Lebedev Physical Institute (Russian Federation); Zmitrenko, N. V. [Russian Academy of Sciences, Keldysh Institute of Applied Mathematics (Russian Federation); Kuchugov, P. A., E-mail: pkuchugov@gmail.com; Rozanov, V. B.; Stepanov, R. V.; Yakhin, R. A. [Russian Academy of Sciences, Lebedev Physical Institute (Russian Federation)

    2017-02-15

    Direct-drive fusion targets are considered at present as an alternative to targets of indirect compression at a laser energy level of about 2 MJ. In this approach, the symmetry of compression and ignition of thermonuclear fuel play the major role. We report on the results of theoretical investigation of compression and burning of spherical direct-drive targets in the conditions of spatial nonuniformity of heating associated with a shift of the target from the beam center of focusing and possible laser radiation energy disbalance in the beams. The investigation involves numerous calculations based on a complex of 1D and 2D codes RAPID, SEND (for determining the target illumination and the dynamics of absorption), DIANA, and NUT (1D and multidimensional hydrodynamics of compression and burning of targets). The target under investigation had the form of a two-layer shell (ablator made of inertial material CH and DT ice) filled with DT gas. We have determined the range of admissible variation of compression and combustion parameters of the target depending on the variation of the spatial nonuniformity of its heating by a multibeam laser system. It has been shown that low-mode (long-wavelength) perturbations deteriorate the characteristics of the central region due to less effective conversion of the kinetic energy of the target shell into the internal energy of the center. Local initiation of burning is also observed in off-center regions of the target in the case of substantial asymmetry of irradiation. In this case, burning is not spread over the entire volume of the DT fuel as a rule, which considerably reduces the thermonuclear yield as compared to that in the case of spherical symmetry and central ignition.

  12. Risk Assessment for Parents Who Suspect Their Child Has Autism Spectrum Disorder: Machine Learning Approach.

    Science.gov (United States)

    Ben-Sasson, Ayelet; Robins, Diana L; Yom-Tov, Elad

    2018-04-24

    Parents are likely to seek Web-based communities to verify their suspicions of autism spectrum disorder markers in their child. Automated tools support human decisions in many domains and could therefore potentially support concerned parents. The objective of this study was to test the feasibility of assessing autism spectrum disorder risk in parental concerns from Web-based sources, using automated text analysis tools and minimal standard questioning. Participants were 115 parents with concerns regarding their child's social-communication development. Children were 16- to 30-months old, and 57.4% (66/115) had a family history of autism spectrum disorder. Parents reported their concerns online, and completed an autism spectrum disorder-specific screener, the Modified Checklist for Autism in Toddlers-Revised, with Follow-up (M-CHAT-R/F), and a broad developmental screener, the Ages and Stages Questionnaire (ASQ). An algorithm predicted autism spectrum disorder risk using a combination of the parent's text and a single screening question, selected by the algorithm to enhance prediction accuracy. Screening measures identified 58% (67/115) to 88% (101/115) of children at risk for autism spectrum disorder. Children with a family history of autism spectrum disorder were 3 times more likely to show autism spectrum disorder risk on screening measures. The prediction of a child's risk on the ASQ or M-CHAT-R was significantly more accurate when predicted from text combined with an M-CHAT-R question selected (automatically) than from the text alone. The frequently automatically selected M-CHAT-R questions that predicted risk were: following a point, make-believe play, and concern about deafness. The internet can be harnessed to prescreen for autism spectrum disorder using parental concerns by administering a few standardized screening questions to augment this process. ©Ayelet Ben-Sasson, Diana L Robins, Elad Yom-Tov. Originally published in the Journal of Medical Internet

  13. Culturally relevant science: An approach to math science education for Hispanics. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz de Montellano, B.

    1996-11-14

    As planned a letter was sent out to 17 teachers who had participated in a Summer 1994 workshop on ``Culturally Relevant Science for Hispanics`` at Michigan State. These teachers were supposed to have spent the intervening time developing lesson plans and curricula. The letter requested a report of any activities undertaken and copies of lesson plans and materials developed by February 1996 with a stipend of $400 for satisfactory reports. It was a disappointment to only get 9 responses and not all of them demonstrating a satisfactory level of activity. Diana Marinez, Dean of Science at Texas A and M University, Corpus Christi, who is the other developer of this curriculum and the author reviewed the submitted materials and chose those showing the most promise to be invited to participate in the Summer Writing Workshop. Spring of 1996 and particularly in May--June, the author wrote a partial first draft of a companion volume for the teacher`s manual which would provide a rationale for doing culturally relevant science, present the cultural and the scientific background that teachers would need in order to be able to teach. One of the goals of this curriculum is that it should be off-the-shelf ready to teach and that teachers would not have to do extra research to encourage its adoption. The outline of the book is appendix 1. The Writing Workshop was held at Texas A and M University, Corpus Christi from July 14 to July 27, 1996. Participating teachers chose topics that they were interested in developing and wrote first drafts. These were distributed to all participants and critiqued by the workshop directors before being rewritten. Some teachers were more productive than others depending on their science background. In total an impressive number of lesson plans were written. These lesson plans are listed in Appendix 3. Appendix 4 is a sample lesson. Work still needs to be done on both the source book and the teachers` manual.

  14. Cobertura e inmunorespuesta a la vacunación frente al virus de la hepatitis B en adolescentes de la provincia de Guadalajara

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    Martínez Pérez José A.

    1998-01-01

    Full Text Available FUNDAMENTO. La hepatitis B constituye uno de los mayores problemas de salud a nivel mundial. Una de las medidas para su prevención es la vacunación masiva de los adolescentes. El objetivo de nuestro estudio fue evaluar la cobertura del programa de vacunación sistemática antihepatitis B entre la población de 8º curso de EGB de la provincia de Guadalajara y estudiar la inmunorrespuesta de la misma, relacionándola con otras variables. MÉTODOS. Se trata de un estudio transversal. La cobertura del programa vacunal se estudió en toda la población diana de la provincia. Para el estudio de la inmunorrespuesta se obtuvo una muestra de 338 alumnos, mediante muestreo aleatorio sistemático. Se cuantificaron los títulos de anti-HBs al 6º mes de la tercera dosis, considerándose niveles protectores los iguales o superiores a 10 mU/ml. RESULTADOS. El porcentaje de personas correctamente vacunadas fue del 82,7%. La tasa de seroprotección global fue del 97,5%. El 46,7% de la muestra respondieron con títulos superiores a 1000 mU/ml. Existió relación inversa estadísticamente significativa (p<0,001 entre el nivel de anti-HBs y el de Quetelet. No encontramos diferencias significativas entre los dos sexos al comparar los títulos postvacunales de anti-Hbs CONCLUSIONES. Estimamos satisfactoria la cobertura alcanzada y buena la inmunogenicidad de la vacuna. La obesidad es un factor predictor de baja respuesta a la misma. Esta respuesta no se ve influenciada por el sexo.

  15. The real new economy.

    Science.gov (United States)

    Farrell, Diana

    2003-10-01

    During the soar-and-swoon days of the late 1990s, many people believed that information technology, and the Internet in particular, were "changing everything" in business. A fundamental change did happen in the 1990s, but it was less about technology than about competition. Under director Diana Farrell, the McKinsey Global Institute has conducted an extensive study of productivity and its connection to corporate IT spending and use during that period. The study revealed that information technology is important--but not central--to the fate of industries and individual companies. So if information technology was not the primary factor in the productivity surge, what was? The study points to competition and innovation. In those industries that saw increases in competitive intensity, managers were forced to innovate aggressively to protect their revenues and profits. Those innovations--in products, business practices, and technology--led to the gains in productivity. In fact, a critical dynamic of the new economy--the real new economy--is the virtuous cycle of competition, innovation, and productivity growth. Managers can innovate in many ways, but during the 1990s, information technology was a particularly powerful tool, for three reasons: First, IT enabled the development of attractive new products and efficient new business processes. Second, it facilitated the rapid industrywide diffusion of innovations. And third, it exhibited strong scale economies--its benefits multiplied rapidly as its use expanded. This article reveals surprising data on how various industries in the United States and Europe were affected by competition, innovation, and information technology in the 1990s and offers insights about how managers can get more from their IT investments.

  16. New and extended-action treatments in the management of ADHD: a critical appraisal of lisdexamfetamine in adults and children

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    Diana Domnitei

    2010-05-01

    Full Text Available Diana Domnitei, Vishal MadaanDepartment of Psychiatry, Creighton University Medical Center, Omaha, NE, USAAbstract: Treatment guidelines from the American Academy of Child and Adolescent Psychiatry and the American Academy of Pediatrics state that stimulant medications have the most evidence for safety and efficacy in the treatment of childhood attention deficit hyperactivity disorder (ADHD. Longer-acting stimulants are thus considered as first-line for management of ADHD symptoms. Over the years, concerns about the abuse potential of stimulants have led to the development of alternative formulations of these agents. One such recent development, lisdexamfetamine (LDX was FDA approved for treating ADHD in children in early 2007 and in adults in early 2008. LDX is a prodrug, which when orally ingested, is converted to l-lysine and active d-amphetamine, which is responsible for its therapeutic activity. This unique formulation may lead to a possible reduction of the abuse potential, by bypassing the first-pass metabolism. In fact, a statistically significant difference for the ‘liking’ effects on the Drug Questionnaire Response has been reported with intravenous LDX compared to d-amphetamine. LDX appears to have an efficacy and tolerability profile comparable to other extended-release stimulant formulations used to treat ADHD, but reduced potential for abuse-related liking effects when compared to equivalent amounts of immediate-release d-amphetamine. The most common adverse events include decreased appetite, insomnia, upper abdominal pain, headache, irritability, weight loss, and nausea.Keywords: lisdexamfetamine, attention deficit hyperactivity disorder, adults, children

  17. miRNAs and other non-coding RNAs in posttraumatic stress disorder: A systematic review of clinical and animal studies.

    Science.gov (United States)

    Schmidt, Ulrike; Keck, Martin E; Buell, Dominik R

    2015-06-01

    In the last couple of years, non-coding (nc) RNAs like micro-RNAs (miRNAs), small interference RNAs (siRNAs) and long ncRNAs (lncRNAs) have emerged as promising candidates for biomarkers and drug-targets in a variety of psychiatric disorders. In contrast to reports on ncRNAs in affective disorders, schizophrenia and anxiety disorders, manuscripts on ncRNAs in posttraumatic stress disorder (PTSD) and associated animal models are scarce. Aiming to stimulate ncRNA research in PTSD and to identify the hitherto most promising ncRNA candidates and associated pathways for psychotrauma research, we conducted the first review on ncRNAs in PTSD. We aimed to identify studies reporting on the expression, function and regulation of ncRNAs in PTSD patients and in animals exhibiting a PTSD-like syndrome. Following the PRISMA guidelines for systematic reviews, we systematically screened the PubMed database for clinical and animal studies on ncRNAs in PTSD, animal models for PTSD and animal models employing a classical fear conditioning paradigm. Using 112 different combinations of search terms, we retrieved 523 articles of which we finally included and evaluated three clinical and 12 animal studies. In addition, using the web-based tool DIANA miRPath v2.0, we searched for molecular pathways shared by the predicted targets of the here-evaluated miRNA candidates. Our findings suggest that mir-132, which has been found to be regulated in three of the here included studies, as well as miRNAs with an already established role in Alzheimer's disease (AD) seem to be particularly promising candidates for future miRNA studies in PTSD. These results are limited by the low number of human trials and by the heterogeneity of included animal studies. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Silencing of the major family of NBS-LRR-encoding genes in lettuce results in the loss of multiple resistance specificities.

    Science.gov (United States)

    Wroblewski, Tadeusz; Piskurewicz, Urszula; Tomczak, Anna; Ochoa, Oswaldo; Michelmore, Richard W

    2007-09-01

    The RGC2 gene cluster in lettuce (Lactuca sativa) is one of the largest known families of genes encoding nucleotide binding site-leucine-rich repeat (NBS-LRR) proteins. One of its members, RGC2B, encodes Dm3 which determines resistance to downy mildew caused by the oomycete Bremia lactucae carrying the cognate avirulence gene, Avr3. We developed an efficient strategy for analysis of this large family of low expressed genes using post-transcriptional gene silencing (PTGS). We transformed lettuce cv. Diana (carrying Dm3) using chimeric gene constructs designed to simultaneously silence RGC2B and the GUS reporter gene via the production of interfering hairpin RNA (ihpRNA). Transient assays of GUS expression in leaves accurately predicted silencing of both genes and were subsequently used to assay silencing in transgenic T(1) plants and their offspring. Levels of mRNA were reduced not only for RGC2B but also for all seven diverse RGC2 family members tested. We then used the same strategy to show that the resistance specificity encoded by the genetically defined Dm18 locus in lettuce cv. Mariska is the result of two resistance specificities, only one of which was silenced by ihpRNA derived from RGC2B. Analysis of progeny from crosses between transgenic, silenced tester stocks and lettuce accessions carrying other resistance genes previously mapped to the RGC2 locus indicated that two additional resistance specificities to B. lactucae, Dm14 and Dm16, as well as resistance to lettuce root aphid (Pemphigus bursarius L.), Ra, are encoded by RGC2 family members.

  19. PREFACE: 2nd International Conference on Innovative Materials, Structures and Technologies

    Science.gov (United States)

    Ručevskis, Sandris

    2015-11-01

    The 2nd International Conference on Innovative Materials, Structures and Technologies (IMST 2015) took place in Riga, Latvia from 30th September - 2nd October, 2015. The first event of the conference series, dedicated to the 150th anniversary of the Faculty of Civil Engineering of Riga Technical University, was held in 2013. Following the established tradition, the aim of the conference was to promote and discuss the latest results of industrial and academic research carried out in the following engineering fields: analysis and design of advanced structures and buildings; innovative, ecological and energy efficient building materials; maintenance, inspection and monitoring methods; construction technologies; structural management; sustainable and safe transport infrastructure; and geomatics and geotechnics. The conference provided an excellent opportunity for leading researchers, representatives of the industrial community, engineers, managers and students to share the latest achievements, discuss recent advances and highlight the current challenges. IMST 2015 attracted over 120 scientists from 24 countries. After rigorous reviewing, over 80 technical papers were accepted for publication in the conference proceedings. On behalf of the organizing committee I would like to thank all the speakers, authors, session chairs and reviewers for their efficient and timely effort. The 2nd International Conference on Innovative Materials, Structures and Technologies was organized by the Faculty of Civil Engineering of Riga Technical University with the support of the Latvia State Research Programme under the grant agreement "INNOVATIVE MATERIALS AND SMART TECHNOLOGIES FOR ENVIRONMENTAL SAFETY, IMATEH". I would like to express sincere gratitude to Juris Smirnovs, Dean of the Faculty of Civil Engineering, and Andris Chate, manager of the Latvia State Research Programme. Finally, I would like to thank all those who helped to make this event happen. Special thanks go to Diana

  20. Clinical features of adolescents with deliberate self-harm: A case control study in Lisbon, Portugal

    Directory of Open Access Journals (Sweden)

    Diogo F Guerreiro

    2009-11-01

    Full Text Available Diogo F Guerreiro, Ema L Neves, Rita Navarro, Raquel Mendes, Ana Prioste, Diana Ribeiro, Tiago Lila, António Neves, Mónica Salgado, Nazaré Santos, Daniel SampaioYouth Suicide Study Group (NES, The Hospital Santa Maria, Psychiatry Department, Lisbon Faculty of Medicine, PortugalAbstract: Deliberate self-harm (DSH among adolescents is a high-risk condition for suicide. The aim of the present study is to describe the characteristic clinical features of adolescents with DSH according to our local context (Lisbon, Portugal, using easily available information from clinical settings. A case control study was constructed from a sample of 100 adolescents (aged 12 to 21 years. The sample was divided into two groups: adolescents with and without DSH. Case files were examined and data was completed by clinical interviews. Demographic, psychosocial, and psychopathological data were assessed and compared. Ninety-eight subjects completed the protocol. The DSH group was associated with the following: suicidal ideation or suicidal behavior as consultation motive, emergency room referral, previous follow-up attempts, suicidal ideation, psychosocial difficulties, or lack of therapeutic goals. There was a nonsignificant trend towards diagnosis of depression in the DSH group. These results reflect our clinical practice with adolescents and add data about teenagers who self-harm to the literature. Prevention and early recognition of DSH (and frequently associated depression in adolescents are essential and could be life-saving measures. An integrated approach, which takes into account psychosocial difficulties, family dysfunction, and negative expectations, seems to be of great importance.Keywords: deliberate self-harm, suicide, adolescents, suicide risk, case control

  1. The 12th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof. Dr. Matei Bals” and the 12th National Infectious Diseases Conference

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    Cristian-Mihail Niculae

    2016-11-01

    Full Text Available Table of contents A1 The outcome of patients with recurrent versus non-recurrent pneumococcal meningitis in a tertiary health-care hospital in Bucharest Cristian-Mihail Niculae, Eliza Manea, Raluca Jipa, Simona Merisor, Ruxandra Moroti, Serban Benea, Adriana Hristea A2 Influence of bacteriophages on sessile Gram-positive and Gram-negative bacteria Alina Cristina Neguț, Oana Săndulescu, Anca Streinu-Cercel, Dana Mărculescu, Magdalena Lorena Andrei, Veronica Ilie, Marcela Popa, Coralia Bleotu, Carmen Chifiriuc, Mircea Ioan Popa, Adrian Streinu-Cercel A3 The utility of inflammatory biomarkers in the prognostic evaluation of septic patients – past, present and future Alina Orfanu, Cristina Popescu, Anca Leuștean, Remulus Catană, Anca Negru, Alexandra Badea, Radu Orfanu, Cătălin Tilișcan, Victoria Aramă, Ştefan Sorin Aramă A4 Etiologic and clinical features of bacterial meningitis in infants Constanța-Angelica Vișan, Anca-Cristina Drăgănescu, Anuța Bilașco, Camelia Kouris, Mădălina Merișescu, Magdalena Vasile, Diana-Maria Slavu, Sabina Vintilă, Endis Osman, Alina Oprea, Sabina Sandu, Monica Luminos A5 The diagnostic and prognostic role of neutrophil to lymphocyte count ratio in sepsis Alina Orfanu, Victoria Aramă, Ştefan Sorin Aramă, Anca Leuştean, Remulus Catană, Anca Negru, Gabriel Adrian Popescu, Cristina Popescu A6 Whooping cough in a HIV positive patient Ramona Georgiana Stanculete, Ana Vaduva Enoiu, Adelina Raluca Marinescu, Voichita Lazureanu A7 Cronobacter sakazakii sepsis in varicella patient Adelina-Raluca Marinescu, Alexandru Crișan, Voichița Lăzureanu, Virgil Musta, Narcisa Nicolescu, Ruxandra Laza A8 Anaerobes an underdiagnosed cause of prosthesis joint infection Anca-Ruxandra Negru, Daniela-Ioana Munteanu, Raluca Mihăilescu, Remulus Catană, Olga Dorobăț, Alexandru Rafila, Emilia Căpraru, Marius Niculescu, Rodica Marinescu, Olivera Lupescu, Vlad Predescu, Adrian Streinu-Cercel, Victoria Aramă, Daniela

  2. ÍNDICE

    Directory of Open Access Journals (Sweden)

    MARÍA JESUS MARRON GAITE

    2015-12-01

    Full Text Available PRESENTACIÓN: La investigación en Educación GeográficaCOORDINACIÓN: Ramón Martínez Medina.................................................... 7ARTÍCULOSFormer ses élèves à L’abstraction en géographieBernadette Mérenne-Schoumaker................................................................ 25El paisaje en la Educación Secundaria Obligatoria. Una oportunidad educativa en el cambio curricular LOE-LOMCEMaría Casas Jericó y Luis Erneta Altarriba ...................................................... 4Parques naturales: la necesaria conceptualización transformadora en la Educación Primaria y SecundariaDiana Santana Martín, Antonio José Morales Hernández, Juan Carlos Colomer Rubio, Benito Campo Pais, Carlos Caurín Alonso............................................ 73Le territoire, un concept sensible : enjeux didactiques et politiques dans le contexte scolaire françaisEric Ratzel et Jean-François Thémines..................................................................................................95La obra La recogida de la manzana como pretexto para la lectura e interpretación del paisaje tradicional a través de una fuente iconográfica: un estudio con alumnado de 2º de BachilleratoRoberto García-Morís..................................................................................................... 115Propuesta didáctica para la interpretación del espacio geográfico: la ciudad de Segovia y su entornoLuis Carlos Martínez Fernández, Berta Fernández-Vega Peláez e Ignacio Molina de la Torre.................................................................................................. 135Aportes del enfoque de género para una enseñanza inclusiva de la Geografía escolarMaría Victoria Fernández Caso y Daniela Guberman....................................... 165El modelo TPACK en los estudios de Grado para la formación inicial del profesorado en TIC Isabel Mª Gómez Trigueros

  3. Economics of Distance and Online Learning Theory, Practice and Research

    Directory of Open Access Journals (Sweden)

    reviewed by TOJDE

    2009-10-01

    Learning: The Role of Embedded Learning inCreating a Competitive Workforce, Jade Nguyen Strattner and Diana OblingerSECTION SIX: OPEN AND VIRTUAL SCHOOLINGChapter 13: Open Basic Education: Organizational Structures, Costs and Benefits,Palitha EdirisinghaSECTION SEVEN: RESEARCH AND DEVELOPMENTChapter 14: From Baobab to Bonsai: Revisiting Methodological Issues in the Costs andEconomics of Distance Education and Distributed e-Learning, Thomas HülsmannSECTION EIGHT: EPILOGUEChapter 15: Implications for Planning and Management of Distance and On-lineLearning, William Bramble and Santosh Panda

  4. Obesity, knee osteoarthritis, and polypathology: factors favoring weight loss in older people

    Directory of Open Access Journals (Sweden)

    Isla Pera P

    2016-05-01

    Full Text Available Pilar Isla Pera,1 Ma Carmen Olivé Ferrér,1 Montserrat Nuñez Juarez,2 Esther Nuñez Juarez,3 Loreto Maciá Soler,4 Carmen López Matheu,1 Assumpta Rigol Cuadra,1 María Honrubia Pérez,1 Diana Marre5 1School of Nursing, University of Barcelona, 2Department of Rheumatology, Musculoskeletal Clínic Institute Hospital Clínic, 3Institut Català de la Salut, Barcelona, 4Nursing Department, University of Alicante, Alicante, 5Universitat Autònoma de Barcelona, Barcelona, Spain Aim: We aimed to explore the meaning of obesity in elderly persons with knee osteoarthritis (KO and to determine the factors that encourage or discourage weight loss.Background: Various studies have demonstrated that body mass index is related to KO and that weight loss improves symptoms and functional capacity. However, dietary habits are difficult to modify and most education programs are ineffective.Design: A phenomenological qualitative study was conducted. Intentional sampling was performed in ten older persons with KO who had lost weight and improved their health-related quality of life after participating in a health education program. A thematic content analysis was conducted following the stages proposed by Miles and Huberman.Findings: Participants understood obesity as a risk factor for health problems and stigma. They believed that the cause of obesity was multifactorial and criticized health professionals for labeling them as “obese” and for assigning a moral value to slimness and diet. The factors identified as contributing to the effectiveness of the program were a tolerant attitude among health professionals, group education that encouraged motivation, quantitative dietary recommendations, and a meaningful learning model based on social learning theories.Conclusion: Dietary self-management without prohibitions helped participants to make changes in the quantity and timing of some food intake and to lose weight without sacrificing some foods that were deeply

  5. The Effectiveness of eHealth Technologies on Weight Management in Pregnant and Postpartum Women: Systematic Review and Meta-Analysis.

    Science.gov (United States)

    Sherifali, Diana; Nerenberg, Kara A; Wilson, Shanna; Semeniuk, Kevin; Ali, Muhammad Usman; Redman, Leanne M; Adamo, Kristi B

    2017-10-13

    .55 kg, 95% CI -3.81 to -1.28) after 3 to 12 months and six studies found a nonsignificant reduction in weight gain for pregnant women (-1.62 kg, 95% CI -3.57 to 0.33) at approximately 40 weeks. This review found evidence for benefits of eHealth technologies on weight management in postpartum women only. Further research is still needed regarding the use of these technologies during and after pregnancy. ©Diana Sherifali, Kara A Nerenberg, Shanna Wilson, Kevin Semeniuk, Muhammad Usman Ali, Leanne M Redman, Kristi B Adamo. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 13.10.2017.

  6. Profiling analysis of circulating microRNA in peripheral blood of patients with class IV lupus nephritis.

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    Elkin Navarro-Quiroz

    Full Text Available Renal involvement in Systemic Lupus Erythematous (SLE patients is one of the leading causes of morbidity and a significant contributor to mortality. It's estimated that nearly 50% of SLE individuals develop kidney disease in the first year of the diagnosis. Class IV lupus nephritis (LN-IV is the class of lupus nephritis most common in Colombian patients with SLE. Altered miRNAs expression levels have been reported in human autoimmune diseases including lupus. Variations in the expression pattern of peripheral blood circulating miRNAs specific for this class of lupus nephritis could be correlated with the pathophysiological status of this group of individuals. The aim of this study was to evaluate the relative abundance of circulating microRNAs in peripheral blood from Colombian patients with LN-IV. Circulating miRNAs in plasma of patients with diagnosis of LN-IV were compared with individuals without renal involvement (LNN group and healthy individuals (CTL group. Total RNA was extracted from 10 ml of venous blood and subsequently sequenced using Illumina. The sequences were processed and these were analyzed using miRBase and Ensembl databases. Differential gene expression analysis was carried out with edgeR and functional analysis were done with DIANA-miRPath. Analysis was carried out using as variables of selection fold change (≥2 o ≤-2 and false discovery rate (0.05. We identified 24 circulating microRNAs with differential abundance between LN-IV and CTL groups, fourteen of these microRNAs are described for the first time to lupus nephritis (hsa-miR-589-3p, hsa-miR-1260b, hsa-miR-4511, hsa-miR-485-5p, hsa-miR-584-5p, hsa-miR-543, hsa-miR-153-3p, hsa-miR-6087, hsa-miR-3942-5p, hsa-miR-7977, hsa-miR-323b-3p, hsa-miR-4732-3p and hsa-miR-6741-3p. These changes in the abundance of miRNAs could be interpreted as alterations in the miRNAs-mRNA regulatory network in the pathogenesis of LN, preceding the clinical onset of the disease. The findings

  7. Prevalencia de actividad física y su relación con variables sociodemográficas y estilos de vida en la población de 18 a 65 años de Pamplona

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    José Javier Elizondo-Armendáriz

    2005-01-01

    Full Text Available Fundamento: Los conocimientos actuales permiten considerar que existe una asociación de tipo causal entre el nivel de actividad física y la aparición de diversas enfermedades. A pesar de ello, la actividad física es una práctica poco arraigada en la población, que cada vez se está haciendo más sedentaria. El objetivo de este estudio es describir la prevalencia de sedentarismo en la población de Pamplona, así como conocer cuáles son los factores que más influyen en él. Métodos: Se llevó a cabo un estudio transversal mediante encuesta postal en una muestra significativa de la población de Pamplona de 18 a 65 años. La encuesta utilizada incluía una evaluación de la actividad física realizada, basada en el cuestionario de actividad física de Paffenbarger. Se realizó un análisis bivariado y multivariado con aplicación de regresión logística. Resultados: Un 76,6% de las mujeres tienen un estilo de vida sedentario, mientras que en los varones este porcentaje se reduce hasta un 56,7%. El sedentarismo se incrementa con la edad, existiendo hasta un 80,3% de varones sedentarios en el grupo de mayor edad, y un 86,3% entre las mujeres, respectivamente. Conclusiones: Los factores sociodemográficos como sexo, edad, estudios, profesión y estado civil parecen ser determinantes del estilo de vida sedentario, mientras el consumo de tabaco y la existencia de sobrepeso y obesidad no lo son. Entre las personas jóvenes, las mujeres sin estudios universitarios y los varones casados y fumadores parecen ser poblaciones diana para la promoción de la actividad física.

  8. Resultados de la extensión del programa de educación en diabetes a la atención primaria de salud en Ciudad de La Habana Results of the extension of the diabetes education program to primary health care in Havana City

    Directory of Open Access Journals (Sweden)

    Rolando Suárez Pérez

    2005-08-01

    Full Text Available El objetivo del presente trabajo fue evaluar las acciones de extensión del programa de educación en diabetes del Instituto Nacional de Endocrinología a los servicios de la atención primaria de salud de la provincia Ciudad de La Habana. Fueron invitados todos los municipios de la capital para participar en el estudio. En las áreas que aceptaron su incorporación se seleccionó una muestra representativa de sus consultorios, se realizó (al inicio y 4 años después una entrevista al universo de sus médicos y enfermeras y una encuesta a una muestra representativa de su población diabética adulta. Para comparar se aplicaron las pruebas de Chi cuadrado y t de Student, y se aceptó p<0,05 como nivel de significación. De 15 municipios, 12 respondieron al llamado al inicio del estudio y el porcentaje de respuesta fue superior al 90 % en ambos momentos y grupos diana. La información de los proveedores de salud mostró una mejoría significativa en la capacitación de los médicos y enfermeras y una mejor comprensión y destreza para el cuidado y educación de las personas con diabetes. Estos resultados influyeron en una mejor organización de las actividades educativas y en el significativo cambio encontrado en los conocimientos de las personas con diabetes en relación con su enfermedad, así como en las opiniones sobre los servicios recibidos. Se concluye que la evaluación demostró la utilidad del proceso de extensión, además de identificar aquellos aspectos en los que aún hay que continuar reforzando el programa para aumentar la eficacia de su acción.

  9. Comparison of a mouse and a novel human scFv-SNAP-auristatin F drug conjugate with potent activity against EGFR-overexpressing human solid tumor cells

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    Woitok M

    2017-07-01

    Full Text Available Mira Woitok,1,2 Diana Klose,1 Stefano Di Fiore,1 Wolfgang Richter,3 Christoph Stein,1 Gerrit Gresch,1 Elena Grieger,1 Stefan Barth,1 Rainer Fischer,1,2 Katharina Kolberg,1,* Judith Niesen1,* 1Fraunhofer Institute for Molecular Biology and Applied Ecology (IME, Aachen, Germany; 2Institute of Molecular Biotechnology (Biology VII, RWTH Aachen University, Aachen, Germany; 3Tube Pharmaceuticals GmbH, Vienna, Austria *These authors contributed equally to this work Abstract: Antibody–drug conjugates (ADCs can deliver toxins to specific targets such as tumor cells. They have shown promise in preclinical/clinical development but feature stoichiometrically undefined chemical linkages, and those based on full-size antibodies achieve only limited tumor penetration. SNAP-tag technology can overcome these challenges by conjugating benzylguanine-modified toxins to single-chain fragment variables (scFvs with 1:1 stoichio­metry while preserving antigen binding. Two (human and mouse scFv-SNAP fusion proteins recognizing the epidermal growth factor receptor (EGFR were expressed in HEK 293T cells. The purified fusion proteins were conjugated to auristatin F (AURIF. Binding activity was confirmed by flow cytometry/immunohistochemistry, and cytotoxic activity was confirmed by cell viability/apoptosis and cell cycle arrest assays, and a novel microtubule dynamics disassembly assay was performed. Both ADCs bound specifically to their target cells in vitro and ex vivo, indicating that the binding activity of the scFv-SNAP fusions was unaffected by conjugation to AURIF. Cytotoxic assays confirmed that the ADCs induced apoptosis and cell cycle arrest at nanomolar concentrations and microtubule disassembly. The SNAP-tag technology provides a platform for the development of novel ADCs with defined conjugation sites and stoichiometry. We achieved the stable and efficient linkage of AURIF to human or murine scFvs using the SNAP-tag technology, offering a strategy to

  10. INERA Workshop 2016: Membrane and Liquid Crystal Nanostructures (MELINA 2016)

    International Nuclear Information System (INIS)

    2017-01-01

    Journal of Physics: Conference Series. The proceedings of conferences and workshops organized in the frames of INERA Project are regularly published by the Journal of Physics: Conference Series. The Editorial Committee members are very grateful to the journal’s staff for providing us this opportunity, as well as for the continuous support for the publication of these Proceedings. Managing Editor: Assoc. Prof. Dr. Julia Genova Co-editors: Prof. DSc. Diana Nesheva Prof. DSc. Isak Bivas Assoc. Prof. Dr. Yordan Marinov Assoc. Prof. Dr. Victoria Vitkova Assoc. Prof. Dr. Georgi Hadjichristov (paper)

  11. Entérate de cómo cambia el cerebro cuando se lesiona un nervio

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    Julieta Troncoso

    2016-02-01

    Full Text Available Desde hace algunos años el grupo de investigación de Neurofisiología Comportamental de la Universidad Nacional de Colombia ha venido evaluando los cambios que ocurren en el sistema nervioso central luego de la lesión de un nervio periférico. Específicamente trabajamos con el modelo de lesión del nervio facial en roedores para evaluar las modificaciones funcionales y estructurales que ocurren en la corteza sensoriomotora primaria luego de la lesión. Al lesionarse el nervio facial, el cerebro entra en un programa de reorganización que incluye cambios electrofisiológicos en las neuronas de la corteza motora que comandan los movimientos faciales (M1. En este sentido, las células de la corteza motora cerebral se vuelven más excitables y modifican su respuesta ante estímulos sensoriales. La reorganización tras la lesión también incluye cambios morfológicos en M1: las células piramidales de la corteza motora retraen su árbol dendrítico y disminuye la densidad de sus espinas dendríticas. En asociación con estos cambios, las células de M1 disminuyen transitoriamente su inmunorreactividad para NeuN (marcador específico de núcleos neuronales y aumentan la expresión de GAP43 (proteína de crecimiento axonal. Esto indica, posiblemente, un cambio metabólico celular en asociación con la búsqueda de nuevas dianas sinápticas. Finalmente, hallamos que la glía circundante en M1 (tanto astrocitos como microglía se activa de manera muy temprana luego de lesiones del nervio facial. Esto podría indicar que el remodelamiento estructural y funcional hallado en las neuronas corticales es el resultado de la interacción entre la activación de la glía circundante y las células piramidales de M1 (aunque se necesitan muchos experimentos adicionales que así lo demuestren.

  12. Factores asociados al bajo peso al nacer

    Directory of Open Access Journals (Sweden)

    Georgina J Peraza Roque

    2001-10-01

    Full Text Available El bajo peso al nacer (BPN ha constituido un enigma en la ciencia a través de los tiempos. Múltiples son las investigaciones realizadas acerca de las causas que lo producen y las consecuencias que provoca. Su importancia no solo radica en lo que significa en la morbilidad y la mortalidad infantil, sino que estos niños tienen habitualmente múltiples problemas posteriores. El Programa para la Reducción del BPN señala que los niños nacidos con un peso inferior a los 2 500 g presentan riesgo de mortalidad 14 veces mayor durante el primer año de vida, en comparación con los niños que nacen con un peso normal a término. Dentro de los factores de riesgo del BPN se han encontrado con mayor frecuencia en estudios realizados por diferentes autores, los siguientes: el embarazo en la adolescencia, la desnutrición en la madre, el hábito de fumar, la hipertensión arterial durante el embarazo, la sepsis cervicovaginal, la anemia y los embarazos gemelares, entre otros. Es innegable la influencia que el BPN tiene sobre las futuras generaciones, por lo que debe constituir la diana de los esfuerzos que el médico y la enfermera deben desarrollar en su prevención, sobre todo en la comunidadLow birth weight has been an enigma for Science through times. A lot of research works have been carried out about its causes and consequences. The importance of LBW not only lies in its meaning for infant mortality and morbidity but also in the many problems that low birth weight children regularly face in the future. The program for the reduction of LBW points out that newborns weighing under 2500g have during his/her first year of life a mortality risk 14 times higher than newborns with a normal weight at term. Among the low birth weight risk factors, a number of studies by various authors have frequently found the following; pregnancy at adolescence; undernourishment in mothers, smoking, blood hypertension during pregnancy, cervix-vaginal sepsis; anemia, twin

  13. Molecular diagnosis of microbial copathogens with influenza A(H1N1pdm09 in Oaxaca, Mexico

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    Ramírez-Palacios LR

    2018-04-01

    Full Text Available Luis Román Ramírez-Palacios,1 Diana Reséndez-Pérez,2 Maria Cristina Rodríguez-Padilla,2 Santiago Saavedra-Alonso,2 Olga Real-Najarro,3 Nadia A Fernández-Santos,4 Mario A Rodriguez Perez4 1Laboratorio Estatal de Salud Pública de Oaxaca, Oaxaca, 2Departamento de Inmunología y Virología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Mexico; 3Consejería de Educación, Madrid, Spain; 4Instituto Politécnico Nacional (IPN, Centro de Biotecnología Genómica, Reynosa, Mexico Background: Multiple factors have been associated with the severity of infection by influenza A(H1N1pdm09. These include H1N1 cases with proven coinfections showing clinical association with bacterial contagions. Purpose: The objective was to identify H1N1 and copathogens in the Oaxaca (Mexico population. A cross-sectional survey was conducted from 2009 to 2012. A total of 88 study patients with confirmed H1N1 by quantitative RT-PCR were recruited. Methods: Total nucleic acid from clinical samples of study patients was analyzed using a TessArray RPM-Flu microarray assay to identify other respiratory pathogens. Results: High prevalence of copathogens (77.3%; 68 patients harbored one to three pathogens, predominantly from Streptococcus, Haemophilus, Neisseria, and Pseudomonas, were detected. Three patients (3.4% had four or five respiratory copathogens, whereas others (19.3% had no copathogens. Copathogenic occurrence with Staphylococcus aureus was 5.7%, Coxsackie virus 2.3%, Moraxella catarrhalis 1.1%, Klebsiella pneumoniae 1.1%, and parainfluenza virus 3 1.1%. The number of patients with copathogens was four times higher to those with H1N1 alone (80.68% and 19.32%, respectively. Four individuals (4.5%; two males, one female, and one infant who died due to H1N1 were observed to have harbored such copathogens as Streptococcus, Staphylococcus, Haemophilus, and Neisseria. Conclusion: In summary, copathogens were found in a

  14. Effects of 3% trehalose as an adjuvant treatment after LASIK

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    Mateo Orobia AJ

    2017-02-01

    Full Text Available Antonio J Mateo Orobia,1–3 Paula Casas Pascual,1,4 José Á Cristóbal Bescós,1 Diana Perez García,1,4 Carlos Peiro Embid,1,4 M Ángeles del Buey Sayas,1,4 Valentyna Korobko Kulikova,1 Noelia Lafuente Ojeda5 1Department of Ophthalmology, Hospital Quirón, 2Department of Ophthalmology, Hospital Universitario Miguel Servet, 3Instituto de Investigación Sanitaria de Aragón (IIS, 4Department of Ophthalmology, Hospital Clínico Universitario Lozano-Blesa, 5Department of Anesthesiology, Hospital Universitario Miguel Servet, Zaragoza, Spain Purpose: To evaluate the effect of 3% trehalose as an adjuvant in the standard treatment after laser-assisted in situ keratomileusis.Design: Interventional prospective comparative single-blind study.Setting: Department of Ophthalmology, Hospital Quirón Zaragoza, Spain.Methods: A total of 26 eyes (13 patients were included, of which 12 eyes (group 1 received conventional treatment with lubricant drops of hyaluronic acid (0.15% and 14 eyes (group 2 received, additionally, an ophthalmic solution of 3% trehalose. Pre- and postoperative quality-of-life tests and vital stains, tear breakup time, and osmolarity measurements were made.Results: We obtained statistically significant differences between the groups in the Symptom Assessment in Dry Eye test in all visits with respect to severity, and in the postoperative day 1 visit with respect to frequency, in all cases favoring the trehalose treatment. The values of osmolarity were not significantly different between groups. However, we did find significant differences in the Oxford scale in day 90 for the trehalose treatment (P<0.001, and in the National Eye Institute scale in day 30 (P=0.02.Conclusion: The results of this exploratory study indicate that the adjuvant treatment with 3% trehalose could be superior with respect to the standard treatment, with improvements in the objective and subjective parameters of tear quality. Keywords: dry eye syndrome, trehalose

  15. Camões e a cosmogonia

    Science.gov (United States)

    Costa, J. M.

    2003-08-01

    Os Lusíadas, escrito por Luis de Camões em 1572, é um poema épico renascentista e a visão Cosmogônica do autor é apresentada, principalmente, no último canto do poema, quando Tétis mostra ao Gama a Máquina do Mundo. A Cosmogonia de Camões neste poema reflete uma visão de uma época de transição, que ainda não incorporou os elementos da revolução Copernicana. É uma visão Grego- Ptolomaica e também medieval. O poeta guia-se pela tradução e notas feita por Pedro Nunes, inventor do Nonio, do Tratado da Esfera "De Sphaera" do Astrônomo Inglês John Holywood, mais conhecido pelo nome latinizado de Johannes Sacrobosco. Outra provável fonte de Camões, de acordo com Luciano Antonio Pereira da Silva em Astronomia de os Lusíadas, é o "Theoricae novae Planetarum" (1460) do astrólogo Alemão Jorge Purbáquio (1423 - 1461). A Astronomia de Os Lusíadas representa a ciência do tempo de Camões. Camões nunca emprega a palavra constelação e seu catálogo é bastante completo. A Máquina do Mundo tem a Terra no centro. Em redor, em círculos concêntricos, a lua (Diana), Mercúrio, Vênus, o Sol (Febo), Marte, Júpiter e Saturno. Envolvendo estes astros tem o firmamento seguido pelo "Céu Áqueo" ou cristalino, depois o 1o Móbil, esfera que arrasta todas as outras consigo. Este trabalho, multidisciplinar, serve tanto para ensinar aos alunos da Física como das Ciências Humanas, a concepção de mundo do renascimento de uma forma belamente poética em versos decassílabos Este trabalho também ajuda na apreciação do maior clássico da língua portuguesa e mostra como as Ciências e as artes, em geral, estão correlacionadas e refletem a visão de mundo da época em que foi produzida.

  16. Estimación de la exposición al humo ambiental de tabaco: revisión de cuestionarios utilizados en España Estimation of environmental tobacco smoke exposure: review of questionnaires used in Spain

    Directory of Open Access Journals (Sweden)

    Manel Nebot

    2011-08-01

    Full Text Available Introducción: En los últimos años, las encuestas de salud y los estudios epidemiológicos sobre el tabaquismo han incorporado preguntas sobre la exposición al humo ambiental de tabaco, aunque no existe un cuestionario estandarizado. Métodos: Entre enero y mayo de 2008 se revisaron las encuestas que contenían preguntas sobre exposición a tabaquismo pasivo realizadas en España desde las administraciones públicas, las sociedades científicas y organismos de investigación. Se han revisado los literales, que se han clasificado según tipo de estudio, población diana, ámbito geográfico y lugar de exposición. Resultados: Se identificaron 27 encuestas que incluían tabaquismo pasivo. La mayoría correspondían a encuestas de salud (81,5% e iban dirigidas a población general (70,4%. El ámbito geográfico más común era el autonómico (48,1% y el lugar de exposición más común el hogar (88,9%. Discusión: Los resultados muestran una enorme variabilidad en las preguntas utilizadas. Es necesario homogeneizar las preguntas sobre exposición al tabaquismo pasivo si queremos comparar los resultados.Introduccion: In the last few years, health surveys and epidemiological studies on smoking have introduced questions on environmental tobacco smoke (ETS exposure. However, a standardized questionnaire is lacking. Methods: Between January and May 2008, we reviewed surveys containing items on ETS exposure carried out in Spain by public administrations, scientific societies and research institutes. The wording of the questions was reviewed and classified according to the study type, target population, geographical setting and place of exposure. Results: We identified 27 surveys that included questions on passive smoking. Most were health surveys (81.5% and were aimed at the general population (70.4%. The most frequent geographical setting consisted of autonomous regions (48.1% and the most common place of exposure was the home (88.9% Discussion: The

  17. Progress in the domain of emissions tracking and environment radioactivity monitoring - Proceedings of the technical days organised by the SFRP Environment Section

    International Nuclear Information System (INIS)

    Calmet, Dominique; Calvez, Marianne; Rivasseau, Corinne Cea; Monfort, Marguerite; Manificat, Guillaume; Pierrard, Olivier; Couvez, Celine; Masson, Olivier; Bruno, Valerie; Renaud, Philippe; Genova, Zhana; Reynal, Nathalie; Le Coz, Eric; Tchilian, Nathalie; Diana, Jean-Jacques; Beguinel, Philippe; Cortes, Pierre; Puydarrieux, Stephane; Brun, Thierry; Devin, Patrick; Clavel, Benoit; Hemidy, Pierre-Yves; Gontier, Gilles; Delloye, Thierry; Mailliat, Alain; Ferreri, Giovanni; LECLERC, Elisabeth

    2015-11-01

    The Environment Section of the French Society of Radiation Protection (SFRP) organized a technical meeting on the progress made in the domain of emissions tracking and environment radioactivity monitoring. This document brings together the abstracts and the presentations (slides) of the different talks given at the meeting: 1 - Environment monitoring at the global, national and local scale: historical overview (Dominique CALMET, CEA); 2 - Evolution of radioactivity monitoring in the environment from 1960 to the present day (Guillaume MANIFICAT, IRSN); 3 - Euratom's legal framework (Zhana GENOVA, CTE); 4 - Main regulatory changes during the last decade (Nathalie REYNAL, ASN); 5 - Progress of standardization works on radioactive effluent emissions control and environment monitoring (Philippe BEGUINEL, BNEN); 6 - From operators' self-monitoring to ASN's inspections: a many components control system (Eric LE COZ, ASN); 7 - Control of effluents and emissions management at CEA Centres (Marianne CALVEZ, CEA); 8 - Liquid and gaseous effluents of ITER experimental facility: description and impacts (Pierre CORTES, IO); 9 - Effluents and emissions management strategy at AREVA NC La Hague facility (Stephane PUYDARRIEUX, AREVA); 10 - Radioactive effluents from nuclear facilities ongoing deconstruction: from dimensioning to real effluents (Benoit CLAVEL, EDF); 11 - Radionuclides decontamination process for liquid effluents using micro-algae at the laboratory scale (Corinne RIVASSEAU, CEA); 12 - Radioactive effluents from nuclear medicine services: management, monitoring and impact measurement methods (Nathalie TCHILIAN, ASN); 13 - Evolution history of effluents management and environment monitoring at the Solvay La Rochelle site (Thierry DELLOYE, SOLVAY); 14 - Different international approaches in effluents management and monitoring: example of French and German gaseous effluents - regulation, analyses, accounting rules (Jean-Jacques DIANA, ASN); 15 - Environment

  18. Abdomen y corazón. ¿El primer paso del síndrome cardiorrenal?

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    Carlos Ruben Lopez P.

    2017-01-01

    Full Text Available A pesar de los grandes avances en la cardiología en el siglo XX y XXI, la insuficiencia cardiaca sigue suponiendo la principal causa de hospitalización en las personas ancianas y presentando un pronóstico ominoso. Además, a pesar de los múltiples estudios sobre nuevas dianas farmacológicas, apenas hemos avanzado en el campo del tratamiento, tal vez porque aún existen lagunas en su fisiopatología. No debemos olvidar que la insuficiencia cardiaca es un compendio de signos y síntomas que engloban múltiples órganos y sistemas.  Mucho se está investigando sobre la relación entre riñón y corazón en forma de síndrome cardiorrenal.  Algo cada vez más en boga es el papel del abdomen en la disfunción orgánica de la insuficiencia cardiaca. En ese sentido, el sistema venoso contiene el 70% del volumen sanguíneo, siendo almacenado en su mayor parte dentro de las vísceras abdominales. Un aumento del tono simpático supone aumento intenso del retorno venoso tan importante como para  aumentar las presiones de llenado y justificar una descompensación cardiaca. La congestión sistémica determina un aumento en la presión intraabdominal que está correlacionada con la disfunción renal en la insuficiencia cardiaca avanzada. La hipoperfusión tisular intestinal supone microtraslocación bacteriana promoviendo el status proinflamatorio típico de este síndrome. La visión holística e integrada de la insuficiencia cardiaca puede suponer un avance tanto en la estratificación del riesgo como en las estrategias terapéuticas. Grandes pasos se están dando en este sentido con estudios sobre la ultrafiltración, paracentesis, diálisis peritoneal, suero hipertónico o fármacos adsorbentes del sodio.

  19. Las habilidades motoras en niños víctimas de maltrato físico

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    Eulalia María Amador Rodero

    2013-01-01

    Full Text Available Objetivo: Aplicar un programa de habilidades motoras en niños víctimas de maltrato físico. Materiales y métodos: Se trata de un estudio cuasiexperimental en el que se aplica el programa de Estimulación de Habilidades Motoras formulado por el grupo POYMOCOR de la Universidad Libre a una población diana conformada por 16 niños víctimas de maltrato físico en la ciudad de Barranquilla (Colombia; los cuales cumplieron con los criterios de inclusión: haber sido víctimas de maltrato físico y no padecer de alteraciones musculoesquéliticas de origen congénito. La participación de los niños fue voluntaria, pre- via autorización de de la ONG que tiene bajo su cuidado a los niños víctimas de maltrato. El estudio fue autorizado por el Centro de Investigación de la Universidad Libre. Para el análisis de la información se utilizó el programa SPSS para estimar las frecuencias de las variables sociodemográficas y las medias y desviaciones estándar de cada subfactor de la Batería Psicomotriz (BPM de Vitor Da Fonseca, utilizada como instrumento de medición en este proyecto. Las diferencias significativas entre las medias de las puntuaciones de cada subfactor resultado de la evaluación antes y después de la intervención se establecie- ron mediante el test T de Students. Resultados: evidenciaron que el programa de estimulación es efectivo para mejorar las habilidades motoras en niños víctimas de maltrato fisico. Conclusiones: Se concluye que el maltrato físico deja secuelas que interfieren con la ad- quisición y desarrollo de habilidades motoras, pero los programas de estimulación, en este caso el formulado por el grupo investigador, son efectivos para que los niños recuperen sus habilidades y destrezas motoras.

  20. Reviews of recent publications

    Directory of Open Access Journals (Sweden)

    1997-06-01

    Modernism by Constantin V. Ponomareff Spanish Studies Cardenal, Ernesto. The Doubtful Strait . Trans. John Lyons by Juan Carlos Galeano Garcia Marquez, Gabriel. Of Love and Other Demons by John Cussen Lindstrom, Naomi. Twentieth-Century Spanish American Fiction by Norma Helsper Meyer, Doris, Ed. Reinterpreting the Spanish American Essay: Women Writers of the 19th and 20th Centuries by Judy Maloof and Fernando Unzueta Nantell, Judith. The Poetry of Francisco Brines: The Deconstructive Effects of Languages by Anita M. Hart Taylor, Diana and Juan Villegas, Eds. Negotiating Performance: Gender, Sexuality, & Theatricality in Latin America by Anne M. Pasero

  1. Conocimientos, actitudes y prácticas relacionados con el consumo de sustancias psicoactivas en estudiantes de enfermería de una universidad del departamento del Atlántico (Colombia

    Directory of Open Access Journals (Sweden)

    Julio Melina Castrillo

    2012-01-01

    Full Text Available Objetivo: Establecer los conocimientos, actitudes y prácticas relacionados con el consumo de sustancias psicoactivas en estudiantes de enfermería de una universidad del departamento del Atlántico. Materiales y métodos: Estudio descriptivo transversal; población diana: estudiantes de primero a octavo semestre de enfermería de una universidad del departamento del Atlántico (Colombia. Fuente de información primaria, instrumento utilizado: encuesta de 37 preguntas validada. La información se procesó en el software SPSS, se tabuló en tablas de frecuencia y asociación, gráficas de barras y sectores, la información resumida se manejó en frecuencias relativas, medidas de tendencia central y se determinó significancia estadística mediante proporciones. Resultados: El 71,5% tiene conocimiento sobre la composición de las sustancias psicoactivas. El 45% está totalmente en desacuerdo con el consumo de sustancias psicoactivas para relacionarse fácilmente con la gente. El 37,2% está totalmente en desacuerdo con consumir sustancias psicoactivas para divertirse. El 90,7% está de acuerdo con la inversión de recursos económicos en programas de rehabilitación, seguimiento de la población afectada por el consumo de drogas. El 55,5 % consumé alcohol, el 22,2% consume éxtasis y el 22,2 restante consume marihuana y bazuco. Conclusiones: Se encontró un balance negativo en cuanto al consumo de sustancias psicoactivas en los estudiantes de enfermería, debido a que la gran mayoría ha consumido sustancias psicoactivas. Además de encontrarse deficiencia relacionada al conocimientos de las mismas, y en cuanto a las actitudes, se concluyó que la mayoría de los sujetos estudiados tiene actitudes favorables relacionadas con la legalización de las sustancias psicoactivas.

  2. Tai chi qigong as a means to improve night-time sleep quality among older adults with cognitive impairment: a pilot randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Chan AWK

    2016-09-01

    Full Text Available Aileen WK Chan, Doris SF Yu, KC Choi, Diana TF Lee, Janet WH Sit, Helen YL Chan The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong SAR, People’s Republic of China Purpose: Age-related cognitive decline is a growing public health concern worldwide. More than a quarter of adults with cognitive impairment experience sleep disturbance. The objective of this pilot study was to evaluate the preliminary effects of tai chi qigong (TCQ on improving the night-time sleep quality of older adults with cognitive impairment. Participants: Older adults with cognitive impairment who complain of sleep disturbance. Methods: A randomized controlled trial with two groups. Fifty-two subjects were recruited from two district elderly community centers and randomly assigned to either the TCQ group (n=27 or the control group (n=25. The intervention group received TCQ training consisting of two 60-minute sessions each week for 2 months. The control group was advised to maintain their usual activities. Sleep quality was measured by the Chinese Pittsburgh Sleep Quality Index. Quality of life was measured by Short-form 12, cognitive functions measured by mini-mental state examination, and subjective memory deficits measured by the memory inventory for Chinese. Results: Data were collected at baseline, 2 months, and 6 months. Significant results were noted at 6 months in the Chinese Pittsburgh Sleep Quality Index global score (P=0.004, sleep duration (P=0.003, habitual sleep efficiency (P=0.002, and the Short-form 12 mental health component (P<0.001. The TCQ participants reported better sleep quality and a better (quality of life mental health component than the control group. Conclusion: TCQ can be considered a useful nonpharmacological approach for improving sleep quality in older adults with cognitive impairment.Clinical trial registration: CUHK_CCT00448 (https://www2.ccrb.cuhk.edu.hk/registry/public/287. Keywords: cognitive decline, mind

  3. MicroRNA profiling reveals dysregulated microRNAs and their target gene regulatory networks in cemento-ossifying fibroma.

    Science.gov (United States)

    Pereira, Thaís Dos Santos Fontes; Brito, João Artur Ricieri; Guimarães, André Luiz Sena; Gomes, Carolina Cavaliéri; de Lacerda, Júlio Cesar Tanos; de Castro, Wagner Henriques; Coimbra, Roney Santos; Diniz, Marina Gonçalves; Gomez, Ricardo Santiago

    2018-01-01

    Cemento-ossifying fibroma (COF) is a benign fibro-osseous neoplasm of uncertain pathogenesis, and its treatment results in morbidity. MicroRNAs (miRNA) are small non-coding RNAs that regulate gene expression and may represent therapeutic targets. The purpose of the study was to generate a comprehensive miRNA profile of COF compared to normal bone. Additionally, the most relevant pathways and target genes of differentially expressed miRNA were investigated by in silico analysis. Nine COF and ten normal bone samples were included in the study. miRNA profiling was carried out by using TaqMan® OpenArray® Human microRNA panel containing 754 validated human miRNAs. We identified the most relevant miRNAs target genes through the leader gene approach, using STRING and Cytoscape software. Pathways enrichment analysis was performed using DIANA-miRPath. Eleven miRNAs were downregulated (hsa-miR-95-3p, hsa-miR-141-3p, hsa-miR-205-5p, hsa-miR-223-3p, hsa-miR-31-5p, hsa-miR-944, hsa-miR-200b-3p, hsa-miR-135b-5p, hsa-miR-31-3p, hsa-miR-223-5p and hsa-miR-200c-3p), and five were upregulated (hsa-miR-181a-5p, hsa-miR-181c-5p, hsa-miR-149-5p, hsa-miR-138-5p and hsa-miR-199a-3p) in COF compared to normal bone. Eighteen common target genes were predicted, and the leader genes approach identified the following genes involved in human COF: EZH2, XIAP, MET and TGFBR1. According to the biology of bone and COF, the most relevant KEGG pathways revealed by enrichment analysis were proteoglycans in cancer, miRNAs in cancer, pathways in cancer, p53-, PI3K-Akt-, FoxO- and TGF-beta signalling pathways, which were previously found to be differentially regulated in bone neoplasms, odontogenic tumours and osteogenesis. miRNA dysregulation occurs in COF, and EZH2, XIAP, MET and TGFBR1 are potential targets for functional analysis validation. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  4. Estudio “Cumple con SAM”

    Directory of Open Access Journals (Sweden)

    Escribá MP

    2009-06-01

    Full Text Available INTRODUCCIÓN Existen estudios que demuestran los beneficios de los sistemas personalizados de dosificación para aumentar la adherencia al tratamiento en pacientes polimedicados. Recientemente se puso en el mercado un sistema de administración de medicamentos (SAM, portable y de pequeño tamaño, que combina un reloj con alarmas programables y varios compartimentos en donde colocar las formas farmacéuticas de los medicamentos. Para la valoración de su utilidad se ha realizado un estudio piloto de satisfacción sobre el SAM entre los pacientes diana de estos dispositivos, solicitando, tras un breve período de uso, su opinión sobre las características del mismo. Se ha evaluando también la mejora del cumplimiento. MATERIAL Y MÉTODOS 43 farmacéuticos comunitarios voluntarios de 26 oficinas de farmacia ubicadas en 5 provincias reclutaron sobre la base de unos criterios de inclusión y exclusión 302 pacientes incumplidores para que utilizasen durante al menos 15 días el SAM y, posteriormente, rellenasen una encuesta de opinión sobre éste. RESULTADOS La opinión del 91% de los pacientes participantes en el estudio es que el SAM es útil, muy útil o imprescindible como sistema de administración de medicamentos. El incumplimiento autocomunicado pasa del 87% al 23% de pacientes. El SAM puede ser útil para los pacientes como sistema de administración de medicamentos en la mejora de la adherencia a su tratamiento farmacológico en la medida en que disminuye los olvidos. Sin embargo, también ponen de manifiesto algunos problemas de diseño mejorables como son el excesivo tamaño, dificultad de apertura e intensidad del sonido. Estos dos últimos problemas dificultan su uso entre la población de mayor edad.

  5. Book Reviews

    Directory of Open Access Journals (Sweden)

    Christien Klaufus, Book Review Editor

    2016-10-01

    Full Text Available American Crossings: Border Politics in the Western Hemisphere, edited by Maiah Jaskoski, Arturo C. Sotomayor & Harold A. Trinkunas, 2015; reviewed by Olivier Thomas Kramsch The Remittance Landscape: Spaces of Migration in Rural Mexico and Urban USA, by Sarah Lynn Lopez, 2015; reviewed by Christien Klaufus Latin America’s Emerging Middle Classes; Economic Perspectives, editado por Jeff Dayton-Johnson, 2015; reseñado por Ludolfo Paramio Cities, Business and the Politics of Urban Violence in Latin America, by Eduardo Moncada,2016; reviewed by Gerard Martin Who Counts? The Mathematics of Death and Life after Genocide, by Diane Nelson, 2015; reviewed by Finn Stepputat Owners of the Sidewalk: Security and Survival in the Informal City, by Daniel Goldstein, 2015; reviewed by Griet Steel Beyond Tradition, Beyond Invention: Cosmic Technologies and Creativity in Contemporary Afro-Cuban Religions, edited by Diana Espírito Santo and Anastasios Panagiotopoulos, 2015; reviewed by Ken Chitwood Cuba and the U.S. Empire. A Chronological History, by Jane Franklin, 2016; reviewed by Edgar Göll Haydée Santamaría, Cuban Revolutionary: She Led by Transgression, by Margaret Randall, 2015; Vilma Espín Guillois: el fuego de la libertad, by Yolanda Ferrer Gómez and Carolina Aguilar Ayerra, 2015; reviewed by Dirk Kruijt Revolutionary Ideology and Political Destiny in Mexico, 1928-1934: Lázaro Cárdenas and Adalberto Tejeda, by Eitan Ginzberg, 2015; reviewed by Heather Fowler-Salamini Political Landscapes: Forest, Conservation and Community in Mexico, by Christopher R. Boyer, 2015; reviewed by Mariel Aguilar-Støen A Sentimental Education for the Working Man. The Mexico City Penny Press, 1900-1910, por Robert M. Buffington, 2015; reseñado por Lucas Poy Pesos and Politics: Business, Elites, Foreigners and Government in Mexico, 1854-1940, by Mark Wasserman, 2015; reviewed by Benedicte Bull State Theory and Andean Politics: New Approaches to the Study

  6. Evaluation on the implementation of respiratory protection measures in old age homes

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    Lee DT

    2017-09-01

    Full Text Available Diana TF Lee,1 Doris Yu,1 Margaret Ip,2 Jennifer YM Tang3 1The Nethersole School of Nursing, The Chinese University of Hong Kong, 2Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Sha Tin, 3Sau Po Centre on Ageing, The University of Hong Kong, Pok Fu Lam, Hong Kong Purpose: Old age homes (OAHs represent a vulnerable community for influenza outbreaks. Effective implementation of respiratory protection measures has been identified as an effective prevention measure to reduce mortality and morbidity caused by such outbreaks. Yet, relatively little is known about this aspect in these homes. This study evaluated the implementation of respiratory protection measures among infection control officers (ICOs and health care workers (HCWs in these homes in Hong Kong.Patients and methods: A territory-wide, cross-sectional survey was conducted in 87 OAHs. A total of 87 ICOs and 1,763 HCWs (including nurses, health workers, care workers, allied HCWs and assistants completed the questionnaires that evaluated the implementation at the organizational level and individual level, respectively. Generalized estimating equations with unstructured working correlation matrix were used to analyze the simultaneous influence of organizational and individual factors on the implementation.Results: At the organizational level, all homes had a policy on respiratory protection and implementation of such measures was generally adequate. Basic resources such as paper towels/hand dryers and equipment disinfectants, however, were rated as most inadequate by HCWs. Training opportunities were also identified as grossly inadequate. Only less than half of the ICOs and HCWs participated in training on infection control either at the initiation of employment or on a regular basis. Twenty-five percent of HCWs even indicated that they had never participated in any infection control training. At the individual level, hand hygiene, among other

  7. Cathelicidin suppresses colon cancer development by inhibition of cancer associated fibroblasts

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    Cheng M

    2014-12-01

    Full Text Available Michelle Cheng,1,* Samantha Ho,1,* Jun Hwan Yoo,1,2,* Deanna Hoang-Yen Tran,1,* Kyriaki Bakirtzi,1 Bowei Su,1 Diana Hoang-Ngoc Tran,1 Yuzu Kubota,1 Ryan Ichikawa,1 Hon Wai Koon1 1Center for Inflammatory Bowel Diseases, Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; 2Digestive Disease Center, CHA University Bundang Medical Center, Seongnam, Republic of Korea *These authors share co-first authorship Background: Cathelicidin (LL-37 in humans and mCRAMP in mice represents a family of endogenous antimicrobial and anti-inflammatory peptides. Cancer-associated fibroblasts can promote the proliferation of colon cancer cells and growth of colon cancer tumors. Methods: We examined the role of cathelicidin in the development of colon cancer, using subcutaneous human HT-29 colon-cancer-cell-derived tumor model in nude mice and azoxymethane- and dextran sulfate-mediated colon cancer model in C57BL/6 mice. We also determined the indirect antitumoral mechanism of cathelicidin via the inhibition of epithelial–mesenchymal transition (EMT of colon cancer cells and fibroblast-supported colon cancer cell proliferation. Results: Intravenous administration of cathelicidin expressing adeno-associated virus significantly reduced the size of tumors, tumor-derived collagen expression, and tumor-derived fibroblast expression in HT-29-derived subcutaneous tumors in nude mice. Enema administration of the mouse cathelicidin peptide significantly reduced the size and number of colonic tumors in azoxymethane- and dextran sulfate-treated mice without inducing apoptosis in tumors and the adjacent normal colonic tissues. Cathelicidin inhibited the collagen expression and vimentin-positive fibroblast expression in colonic tumors. Cathelicidin did not directly affect HT-29 cell viability, but did significantly reduce tumor growth factor-ß1-induced EMT of colon cancer cells. Media conditioned by the

  8. Evaluación de riesgo biológico en el Hospital Rey Don Jaime

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    Salomé Benavent Nácher

    2007-03-01

    Full Text Available Objetivo: El propósito del presente trabajo es realizar una evaluación del riesgo biológico existente para los trabajadores del Hospital con el fin de identificar los puestos de trabajo y microorganismos que suponen mayor riesgo y poder adoptar medidas preventivas. Métodos: Se aplicó la metodología BIOGAVAL de evaluación de riesgo biológico desarrollado por el Gabinete de Seguridad e Higiene de Valencia. Dicho método contempla una identificación de los microorganismos presentes mas probables, su posible daño a la salud, mecanismos de transmisión, porcentaje de población diana vacunado y el efecto protector de las medidas higiénicas. Se aplicó a los distintos puestos de trabajo que presentan riesgo biológico exceptuando cocina. Resultados: Los resultados evidencian un mayor riesgo para los microorganismos de transmisión aérea y con baja protección vacunal, así como un nivel de riesgo superior (comparado con otros trabajadores de los ATS/DUE de urgencias. Conclusiones: El método se ha revelado útil para evidenciar los puestos de trabajo más peligrosos así como los agentes microbiológicos de mayor riesgo. Igualmente aporta una orientación sobre la prioridad para la aplicación de medidas preventivas de control.Objective: The purpose of this work is to realize an evaluation of the existing biological risk for the staff at the hospital with the aim of both identifying the jobs and microorganisms which mean a higher risk and to be able to adopt preventive measures. Methods: It was applied the BIOGAVAL methodology of evaluation of biological risk developed by the Safety and Hygiene Office in Valencia. This method deals with an identification of the most probable present microorganisms, their possible hurt for health, transmission mechanisms, percentage of target population vaccinated and the protective effect of the hygienic measures. It was applied to the different jobs which show biological risk except for the kitchen ones

  9. Book Reviews

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    Book Review Editor, Barbara Hogenboom

    2014-10-01

    Full Text Available The Economic History of the Caribbean since the Napoleonic Wars, by Victor Bulmer-Thomas (2012; reviewed by Gert OostindieSubjects or Citizens: British Caribbean Workers in Cuba, 1900-1960, by Robert Whitney and Graciela Chailloux Laffita (2013; reviewed by Rose Mary AllenDebating Civil-Military Relations in Latin America, editado por David Mares y Rafael Martínez (2014; reseñado por Raul Benitez-ManautComparative Public Policy in Latin America, editado por Jordi Díez y Susan Franceschet (2012; reseñado por Gonzalo DelamazaEntre el desarrollo y el buen vivir. Recursos naturales y conflictos en los territorios indígenas, editado por José Aylwin, Salvador Martí i Puig, Claire Wright y Nancy Yañez (2013; reviewed by Almut Schilling-VacaflorDignity for the Voiceless. Willem Assies’s Anthropological Work in Context, editado por Ton Salman, Salvador Martí i Puig, y Gemma van der Haar (2014; reseñado por Ricardo Calla OrtegaDemocracy in ‘Two Mexicos’; Political Institutions in Oaxaca and Nuevo León, by Guadelupe Correa-Cabrera (2013; reviewed by Jos BartmanWhere the River Ends, by Shaylih Muehlmann (2013; reviewed by Maria L. Cruz-TorresKnowing History in Mexico. An ethnography of Citizenship, by Trevor Stack (2012; reviewed by Raymond BuveFor God and Revolution. Priest, Peasant, and Agrarian Socialism in the Mexican Huasteca, por Mark Saad Saka( 2013; reseñado por Antonio Escobar OhmstedeWorking Women, Entrepreneurs, and the Mexican Revolution: the Coffee Culture of Córdoba, Veracruz, by Heather Fowler-Salamini (2013; reviewed by Robert F. AlegreWar by Other Means. Aftermath in Post-Genocide Guatemala, edited by Carlota McAlister and Diana Nelson (2013; reviewed by Dirk KruijtLucha revolucionaria. Perú, 1958-1967, por Jan Lust (2013; reseñado por Dirk KruijtWomen in War. The Micro-Processes of Mobilization in El Salvador, by Jocelyn Viterna (2013; reviewed by Ralph SprenkelsZero Hunger: Political Culture and Antipoverty Policy in

  10. Registered prevalence of borderline personality disorder in primary care databases Prevalencia registrada del trastorno límite de personalidad en las bases de datos de atención primaria

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    Enric Aragonès

    2013-04-01

    Full Text Available Objective: Borderline personality disorder (BPD is a common personality disorder, with a population prevalence of 1.4-5.9%, although the epidemiology of this disorder in primary care is insufficiently known. Our objective was to determine the registered prevalence of BPD in primary care databases and to study the demographic and clinical characteristics of these patients. Methods: We performed a cross-sectional study of the computerized databases of primary care clinical records. The target population consisted of all adults (> 16 years old registered in the Catalan Health Institute (n = 4,764,729. Results: The prevalence of recorded BPD was 0.017%, and was higher in patients with other mental disorders, particularly substance-abuse disorders (0.161%. These patients had twice as many appointments with the general practitioner as the general population (8.1 vs. 4.4. Conclusion: The number of diagnoses of BPD recorded in primary care is extremely low, which contrasts with the available population-based data.Objetivo: El trastorno límite de la personalidad (TLP es frecuente, con una prevalencia poblacional del 1,4% al 5,9%, aunque la epidemiología de este trastorno en atención primaria es escasamente conocida. Nuestro objetivo es determinar la prevalencia registrada de TLP en atención primaria y estudiar las características de estos pacientes. Métodos: Estudio transversal de las bases de datos informatizadas de las historias clínicas de atención primaria. La población diana son los adultos (>16 años registrados en el Instituto Catalán de la Salud (n = 4.764.729. Resultados: La prevalencia de TLP registrada es del 0,017%, y es mayor en los pacientes con otros trastornos mentales, particularmente trastornos por abuso de sustancias (0,161%. Estos pacientes duplican las visitas al médico general de la población general (8,1 frente a 4,4. Conclusión: Los diagnósticos de TLP registrados en atención primaria son escasos, lo que contrasta

  11. DESARROLLO DE UN MARCO CONCEPTUAL PARA LA EVALUACIÓN DE LA ATENCIÓN A LA CRONICIDAD EN EL SISTEMA NACIONAL DE SALUD

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    Mireia Espallargues

    2016-01-01

    Full Text Available El objetivo del trabajo fue desarrollar un marco conceptual para la evaluación de nuevos programas de gestión clínica y asistencial de carácter integrado en el Sistema Nacional de Salud para la atención a las personas con enfermedades crónicas. Se realizó una revisión exhaustiva de la literatura entre 2002-2013 incluyendo revisiones sistemáticas, metaanálisis e informes con modelos de evaluación y/o evaluaciones de programas. Se estudiaron y describieron programas locales de atención a la cronicidad implementados en Cataluña y se realizaron entrevistas semiestructuradas con expertos clave en el ámbito catalán. El alcance y el marco conceptual se definieron mediante la técnica del brainstorming. De 910 resúmenes identificados, se incluyeron 116 documentos que se referían a marcos conceptuales e indicadores de evaluación a nivel español e internacional. Se identificaron 24 programas de atención a la cronicidad (9 de carácter integrado. El marco conceptual propuesto contempló: 1 la población diana según niveles de complejidad; 2 un enfoque de evaluación de la estructura, procesos y resultados teniendo en cuenta el estado de salud conseguido, el proceso de recuperación y mantenimiento de la salud; y 3 las dimensiones o atributos que se deben evaluar. El marco conceptual propuesto permitirá desarrollar indicadores e implementarlos con un enfoque comunitario, orientados a los resultados y tener una visión territorial o poblacional, que será imprescindible para saber cuál es la estrategia más efectiva, cuáles son los elementos que determinan un mayor éxito y cuáles son los grupos de pacientes que más se pueden beneficiar.

  12. Comportamiento de las crisis hipertensivas en el Área Intensiva Municipal de Centro Habana

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    Edrinson Alfredo Naranjo Casañas

    Full Text Available Introducción: la Hipertensión Arterial continúa siendo una de las enfermedades crónicas más comunes en nuestro país y el mundo, llegando a tener un rol protagónico como factor de riesgo importante para el padecimiento o agravamiento de otras enfermedades letales. Objetivo: caracterizar el comportamiento de las crisis hipertensivas en los pacientes ingresados en el Área Intensiva del Policlínico Docente "Dr. Joaquín Albarrán". Métodos: se realizó una investigación descriptiva, de corte transversal, en el período comprendido entre diciembre de 2010 a diciembre de 2012. El universo estuvo constituido por los 767 pacientes de 15 y más años de edad, de ambos sexos, que acudieron al Servicio de Urgencia del policlínico y requirieron ingreso en la Unidad de Cuidados Intensivos. Los resultados se mostraron en tablas estadísticas de frecuencias absolutas y relativas. Resultados: predominó el ingreso en los grupos de edades de 40-49 años (23,8 %, seguido del grupo de 60 y más (22,1 %. La principal modalidad de crisis se correspondió con las Urgencias Hipertensivas, 442 (57,6 %. El medicamento de mayor uso como tratamiento de la crisis fue el Captopril en tableta con un total de 562 (93,2 %. El principal órgano diana afectado fue el corazón. Conclusiones: el mayor número de ingresos se produjo en los pacientes de 40-49 años de edad con mayoría del sexo masculino; la modalidad de crisis hipertensiva que más se presentó fue las Urgencias Hipertensivas, y el medicamento de mayor uso como tratamiento fue el Captopril en tableta.

  13. MicroRNA profiling in intraocular medulloepitheliomas.

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    Deepak P Edward

    Full Text Available To study the differential expression of microRNA (miRNA profiles between intraocular medulloepithelioma (ME and normal control tissue (CT.Total RNA was extracted from formalin fixed paraffin embedded (FFPE intraocular ME (n=7 and from age matched ciliary body controls (n=8. The clinical history and phenotype was recorded. MiRNA profiles were determined using the Affymetrix GeneChip miRNA Arrays analyzed using expression console 1.3 software. Validation of significantly dysregulated miRNA was confirmed by quantitative real-time PCR. The web-based DNA Intelligent Analysis (DIANA-miRPath v2.0 was used to perform enrichment analysis of differentially expressed (DE miRNA gene targets in Kyoto Encyclopedia of Genes and Genomes (KEGG pathway.The pathologic evaluation revealed one benign (benign non-teratoid, n=1 and six malignant tumors (malignant teratoid, n=2; malignant non-teratoid, n = 4. A total of 88 miRNAs were upregulated and 43 miRNAs were downregulated significantly (P<0.05 in the tumor specimens. Many of these significantly dysregulated miRNAs were known to play various roles in carcinogenesis and tumor behavior. RT-PCR validated three significantly upregulated miRNAs and three significantly downregulated miRNAs namely miR-217, miR-216a, miR-216b, miR-146a, miR-509-3p and miR-211. Many DE miRNAs that were significant in ME tumors showed dysregulation in retinoblastoma, glioblastoma, and precursor, normal and reactive human cartilage. Enriched pathway analysis suggested a significant association of upregulated miRNAs with 15 pathways involved in prion disease and several types of cancer. The pathways involving significantly downregulated miRNAs included the toll-like receptor (TLR (p<4.36E-16 and Nuclear Factor kappa B (NF-κB signaling pathways (p<9.00E-06.We report significantly dysregulated miRNAs in intraocular ME tumors, which exhibited abnormal profiles in other cancers as well such as retinoblastoma and glioblastoma. Pathway analysis

  14. Motivación del personal sanitario en la formación continuada sobre tratamiento quimioterápico

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    José Ramón García Fernández

    Full Text Available Introducción: El tratamiento quimioterápico es una parte fundamental en la actividad de un centro hospitalario. Sin embargo en los hospitales comarcales el desarrollo de esta actividad es especialmente complejo. La formación continuada postgraduada juega un papel central en la optimización del proceso, y la motivación para participar en ella es asimismo fundamental. Material y métodos: Describimos el proceso de realización de un curso de formación continuada en un hospital general básico, así como la motivación del personal para que participe activamente en la formación continuada, con varias técnicas: información exhaustiva previa, implicación directa como docente, beneficios curriculares y económicos, etc. Previo al curso se plantearon 4 objetivos: 1º asistencia de todo el personal de enfermería directamente implicado, 2º aumento de conocimientos generales, 3º adquisición de habilidades especiales y 4º centrar el curso en la asistencia integral al enfermo oncológico. Los objetivos se evaluaron mediante: 1.-lista de asistencia, 2 y 3-cuestionario anónimo previo y al finalizar el curso y 4.-valoración subjetiva. Resultados: Asistieron al curso de forma regular un total de 53 personas sobre una plantilla "diana" de 456, fundamentalmente diplomados universitarios de enfermería (DUE. Los objetivos propuestos se cumplieron respectivamente en un: 75%, 50%, 75% y 100%. Conclusiones: El personal sanitario más motivado en la formación continuada en oncología básica es: diplomados en enfermería, médicos internos residentes y curiosamente técnicos especialistas de laboratorio. El contacto habitual con la preparación y administración de tratamientos citostáticos fue la principal motivación para asistir al curso. Las diversas técnicas de motivación empleadas solo fueron eficaces en el personal predispuesto "a priori" a la realización del curso.

  15. Anti-HER2 antibody and ScFvEGFR-conjugated antifouling magnetic iron oxide nanoparticles for targeting and magnetic resonance imaging of breast cancer

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    Chen H

    2013-10-01

    Full Text Available Hongwei Chen,1,* Liya Wang,1,2,* Qiqi Yu,1,2 Weiping Qian,3 Diana Tiwari,1 Hong Yi,4 Andrew Y Wang,5 Jing Huang,1,2 Lily Yang,3 Hui Mao1,2 1Department of Radiology and Imaging Sciences, 2Center for Systems Imaging, 3Department of Surgery, Emory University School of Medicine, 4Robert Apkarian Electron Microscopy Core, Emory University, Atlanta, GA, 5Ocean NanoTech LLC, Springdale, AK, USA *These authors contributed equally to this work Abstract: Antifouling magnetic iron oxide nanoparticles (IONPs coated with block copolymer poly(ethylene oxide-block-poly(γ-methacryloxypropyltrimethoxysilane (PEO-b-PγMPS were investigated for improving cell targeting by reducing nonspecific uptake. Conjugation of a HER2 antibody, Herceptin®, or a single chain fragment (ScFv of antibody against epidermal growth factor receptor (ScFvEGFR to PEO-b-PγMPS-coated IONPs resulted in HER2-targeted or EGFR-targeted IONPs (anti-HER2-IONPs or ScFvEGFR-IONPs. The anti-HER2-IONPs bound specifically to SK-BR-3, a HER2-overexpressing breast cancer cell line, but not to MDA-MB-231, a HER2-underexpressing cell line. On the other hand, the ScFvEGFR-IONPs showed strong reactivity with MDA-MB-231, an EGFR-positive human breast cancer cell line, but not with MDA-MB-453, an EGFR-negative human breast cancer cell line. Transmission electron microscopy revealed internalization of the receptor-targeted nanoparticles by the targeted cancer cells. In addition, both antibody-conjugated and non-antibody-conjugated IONPs showed reduced nonspecific uptake by RAW264.7 mouse macrophages in vitro. The developed IONPs showed a long blood circulation time (serum half-life 11.6 hours in mice and low accumulation in both the liver and spleen. At 24 hours after systemic administration of ScFvEGFR-IONPs into mice bearing EGFR-positive breast cancer 4T1 mouse mammary tumors, magnetic resonance imaging revealed signal reduction in the tumor as a result of the accumulation of the targeted IONPs

  16. Perturbed microRNA Expression by Mycobacterium tuberculosis Promotes Macrophage Polarization Leading to Pro-survival Foam Cell.

    Science.gov (United States)

    Ahluwalia, Pankaj Kumar; Pandey, Rajan Kumar; Sehajpal, Prabodh Kumar; Prajapati, Vijay Kumar

    2017-01-01

    Tuberculosis (TB) is one of the prevalent causes of death worldwide, with 95% of these deaths occurring in developing countries, like India. The causative agent, Mycobacterium tuberculosis (MTb) has the tenacious ability to circumvent the host's immune system for its own advantage. Macrophages are one of the phagocytic cells that are central to immunity against MTb. These are highly plastic cells dependent on the milieu and can showcase M1/M2 polarization. M1 macrophages are bactericidal in action, but M2 macrophages are anti-inflammatory in their immune response. This computational study is an effort to elucidate the role of miRNAs that influences the survival of MTb in the macrophage. To identify the miRNAs against critical transcription factors, we selected only conserved hits from TargetScan database. Further, validation of these miRNAs was achieved using four databases viz . DIANA-microT, miRDB, miRanda-mirSVR, and miRNAMap. All miRNAs were identified through a conserved seed sequence against the 3'-UTR of transcription factors. This bioinformatics study found that miR-27a and miR-27b has a putative binding site at 3'-UTR of IRF4, and miR-302c against IRF5. miR-155, miR-132, and miR-455-5p are predicted microRNAs against suppressor of cytokine signaling transcription factors. Several other microRNAs, which have an affinity for critical transcription factors, are also predicted in this study. This MTb-associated modulation of microRNAs to modify the expression of the target gene(s) plays a critical role in TB pathogenesis. Other than M1/M2 plasticity, MTb has the ability to convert macrophage into foam cells that are rich in lipids and cholesterol. We have highlighted few microRNAs which overlap between M2/foam cell continuums. miR-155, miR-33, miR-27a, and miR-27b plays a dual role in deciding macrophage polarity and its conversion to foam cells. This study shows a glimpse of microRNAs which can be modulated by MTb not only to prevent its elimination but also

  17. Interacciones de las proteínas disulfuro isomerasa y de choque térmico Hsc70 con proteínas estructurales recombinantes purificadas de rotavirus

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    Luz Y. Moreno

    2016-01-01

    Full Text Available Introducción. La entrada de rotavirus a las células parece estar mediado por interacciones secuenciales entre las proteínas estructurales virales y algunas moléculas de la superficie celular. Sin embargo, los mecanismos por los cuales el rotavirus infecta la célula diana aún no se comprenden bien. Existe alguna evidencia que muestra que las proteínas estructurales de rotavirus VP5* y VP8* interactúan con algunas moléculas de la superficie celular. La disponibilidad de las proteínas estructurales de rotavirus recombinantes en cantidad suficiente se ha convertido en un aspecto importante para la identificación de las interacciones específicas de los receptores virus-célula durante los eventos tempranos del proceso infeccioso. Objetivo. El propósito del presente trabajo es realizar un análisis de las interacciones entre las proteínas estructurales de rotavirus recombinante VP5*, VP8* y VP6, y las proteínas celulares Hsc70 y PDI utilizando sus versiones recombinantes purificadas. Materiales y métodos. Las proteínas recombinantes de rotavirus VP5* y VP8* y las proteínas recombinantes celulares Hsc70 y PDI se expresaron en E. coli BL21 (DE3, mientras que VP6 se expresó en células MA104 con virus vaccinia recombinante transfectada. La interacción entre el rotavirus y las proteínas celulares se estudió mediante ELISA, co-inmunoprecipitación y SDS-PAGE/ Western. Resultados. Las condiciones óptimas para la expresión de proteínas recombinantes se determinaron y se generaron anticuerpos contra ellas. Los resultados sugirieron que las proteínas virales rVP5* y rVP6 interactúan con Hsc70 y PDI in vitro. También se encontró que éstas proteínas virales recombinantes interactúan con Hsc70 en las balsas lipídicas (“Rafts” en un cultivo celular. El tratamiento de las células, ya sea con DLP o rVP6 produjo significativamente la inhibición de la infección por rotavirus. Conclusión. Los resultados permiten concluir que r

  18. ATENCION PRIMARIA Y RESPONSABILIDADES DE SALUD PÚBLICA EN SEIS PAÍSES DE EUROPA Y AMÉRICA DEL NORTE: UN ESTUDIO PILOTO

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    Barbara Starfield

    2004-01-01

    Full Text Available Fundamento: Los rápidos cambios en los sistemas sanitarios son una oportunidad para reorientar las relaciones entre sus diferentes componentes. Con el objetivo de conocer dónde se ubica la responsabilidad para la realización de diferentes tipos de actividades preventivas, se realizó una encuesta en ocho áreas geográficas de seis países de Europa y Norteamérica. Métodos: Encuesta entre expertos basada en una matriz que relaciona servicios sanitarios preventivos con la población a la que se dirigen. Se establecieron ocho situaciones clínicas (vacunaciones infantiles y antigripal adultos; y detección precoz: de cáncer mediante mamografía, de tuberculosis, de Hipertensión Arterial, de fenilcetonuria, del virus de la inmunodeficiencia humana, y de osteoporosis, con el fin de conocer en relación a las mismas la población diana, nivel de establecimiento de las políticas, nivel de contacto con los individuos, seguimiento de los individuos con diagnósticos positivos y registro de sus datos clínicos. Resultados: Este estudio piloto mostró muy escasa coincidencia de los resultados tanto entre las ocho áreas encuestadas como en cada una de ellas. No se encontró un patrón regular para las actividades de prevención exploradas entre los diferentes países, ni en función de la tipología de sus sistemas sanitarios, ni por la orientación hacia la atención primaria de los diferentes sistemas. Conclusiones: Existe un escaso consenso en las áreas estudiadas en relación con la mejor forma de realizar las intervenciones de salud pública que conllevan prestación de atención sanitaria personal.

  19. PREVALENCIA DEL DÉFICIT DE ATENCIÓN E HIPERACTIVIDAD EN PERSONAS ADULTAS SEGÚN EL REGISTRO DE LAS HISTORIAS CLÍNICAS INFORMATIZADAS DE ATENCIÓN PRIMARIA

    Directory of Open Access Journals (Sweden)

    Enric Aragonès

    2010-01-01

    Full Text Available Fundamento:El TDAH en adultos no es infrecuente y, según datos epidemiológicos recientes, tiene una prevalencia poblacional del 3-4%. Sin embargo, existe un gran desconocimiento sobre este trastorno entre los médicos, particularmente en atención primaria. El objetivo de este trabajo es determinar la prevalencia del diagnóstico registrado de TDAH en adultos y la proporción de pacientes con prescripción farmacológica para este trastorno en atención primaria. Métodos:Se trata de un estudio transversal sobre las bases de datos de las historias clínicas electrónicas de atención primaria. La población diana son los adultos (18-44 años adscritos a centros de salud del Instituto Catalán de la Salud (n=2.452.107. Hemos obtenido la proporción de pacientes con diagnóstico de TDAH (código F90/CIE-10 en la lista de problemas activos, y la proporción de pacientes con prescripción activa de un fármaco específico para el TDAH en adultos: metilfenidato, metilfenidato de liberación prolongada o atomoxetina. Resultados:La prevalencia de TDAH registrado es del 0,04% (0,07% en hombres; 0,02% en mujeres. Los pacientes con prescripción para TDAH son el 0,07% (0,08% en hombres; 0,05% en mujeres. El 32,05% de los TDAH tenían prescripción específica. Conclusión:El diagnóstico en adultos de TDAH y el tratamiento específico son extremadamente bajos en atención primaria. Estos resultados contrastan con los datos poblacionales: el TDAH registrado es 1/85 de la prevalencia poblacional.

  20. Nutritive quality of romanian hemp varieties (Cannabis sativa L. with special focus on oil and metal contents of seeds

    Directory of Open Access Journals (Sweden)

    Mihoc Marcela

    2012-10-01

    Full Text Available Abstract Background The study aims to determine the nutritional value of hemp seed expressed by the oil content and by the concentration of metals (Ca, Mg, K, Fe, Mn, Zn and Cd, for five varieties of monoecious and dioecious hemp seeds approved in Romania, comparative with the concentration of these metals in the soil. Results The content of oil in hempseed registers a slight decrease in the production records of 2011, losses due to drought and low levels of precipitation during the growth period. The greatest loss is found in Diana monoecious variety (26.54-20.82% followed by Zenit varieties (27.37-22.97%, Armanca (29.27-25.32%, Silvana (28.89-25.04% and Denise (26.96-25.30%. Siccative hemp oil has a yellowish green color and an iodine index of 140–156 g I2/100 g oil. Hemp seed are rich in mineral based Ca (144–955 mg/100 g seed, Mg (237–694 mg/100 g seed, K (463–2821 mg/100 g seed, Fe (1133-2400 mg.kg-1, Mn (63–110 mg.kg-1 and Zn (42-94 mg.kg-1. For the soil the following macroelements concentrations were determined: Ca (2100–2520 mg.kg-1, Mg (320–376 mg.kg-1 and K (232–257 mg.kg-1. Mn (156–197 mg.kg-1 and Zn (54–67 mg.kg-1 remain within normal limits for Romania. The soils in the experience area contain large amounts of Fe (19000–20430 mg.kg-1. The presence of K in large quantities determines the accumulation of large quantities of Fe in the soil. Conclusion Hempseed belonging to the five Romanian varieties are rich source of nutrients (Ca, Mg, K and unsaturated oil easily digestible by the body, but the presence of Cd concentrations above the upper limit puts a question mark over the use of seeds in various food products. Hemp extracts easily certain metals from the soil. Significant amounts of Fe (1133–2400 mg.kg-1, Mn (63–110 mg.kg-1, Zn (42–94 mg.kg-1 and Cd (1.3-4.0 mg.kg-1 are found in hemp seeds. Hemp (Cannabis sativa L. is included among plants suitable for phytoremediation of soil contaminated with cadmium

  1. Clinical and genetic characteristics in a group of 45 patients with Turner syndrome (monocentric study

    Directory of Open Access Journals (Sweden)

    Bucerzan S

    2017-05-01

    Full Text Available Simona Bucerzan,1 Diana Miclea,1,2 Radu Popp,2 Camelia Alkhzouz,1 Cecilia Lazea,1 Ioan Victor Pop,2 Paula Grigorescu-Sido1 1Emergency Hospital for Children, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; 2Department of Molecular Sciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania Introduction: Recent years have seen a shift in perspective on Turner syndrome, as it is no longer considered a significant disability due to therapeutic advances. The delay of diagnosis and the underdiagnosis are common in Turner syndrome, especially because of the great phenotypic variability and lack of firm diagnostic criteria.Aim: Our first aim was to assess the clinical and the cytogenetic characteristics and growth rate in growth hormone (GH-treated patients as compared to those with spontaneous growth. The second aim was to analyze the Y chromosomal sequences.Materials and methods: We analyzed 45 patients diagnosed with Turner syndrome in Genetic Pathology Centre of Cluj Emergency Children’s Hospital. We carried out a study of the clinical features, the correlations between the karyotype and the phenotype, and we also made a research of Y chromosome sequences.Results: The average age at diagnosis was 8.9±5.4 years. A significant association was observed between the number of external phenotypical abnormalities and internal malformations (r=0.45, particularly the cardiovascular ones (r=0.44. Patients treated with GH showed improvement in growth rate, with final stature significantly better than in untreated patients; benefits following treatment were greater if diagnosis was made before the age of 5 years. Thirteen percent of patients experienced spontaneous and complete puberty, whereas 30% experienced incomplete puberty. Patients with the 45,X genotype had a greater stature deficit and a higher incidence of cardiac malformations, compared with patients with 45,X/46,XX mosaic karyotype. Y

  2. Barrier protective use of skin care to prevent chemotherapy-induced cutaneous symptoms and to maintain quality of life in patients with breast cancer

    Directory of Open Access Journals (Sweden)

    Wohlrab J

    2014-08-01

    Full Text Available Johannes Wohlrab,1 Nikola Bangemann,2 Anke Kleine-Tebbe,3 Marc Thill,4,5 Sherko Kümmel,6 Eva-Maria Grischke,7 Rainer Richter,8 Sophie Seite,9 Diana Lüftner10 1Martin Luther University Halle-Wittenberg, Department of Dermatology and Venereology, Halle (Saale, 2Interdisciplinary Breast Centre, University Hospital Charité Berlin, Campus Benjamin Franklin, Berlin, Germany, 3Breast Centre DRK Hospital, Berlin, 4Breast Centre University of Lübeck, Department of Gynaecology and Obstetrics, Lübeck, 5Department of Gynaecology and Obstetrics, Agaplesion Markus Hospital, Frankfurt am Main, 6Breast Centre and Clinic of Senology, Hospital Essen-Mitte, Essen, 7Breast Centre University of Tübingen, Department of Gynaecology, Tübingen, 8L'Oréal, Deutschland GmbH, Düsseldorf, 9La Roche-Posay, Dermatological Laboratories, Asnières, France; 10University Hospital Charité Berlin, Campus Benjamin Franklin, Department of Hematology, Oncology and Tumour Immunology, Berlin, Germany Purpose: Chemotherapy with anthracyclines, taxanes, or alkylating agents often causes cutaneous side effects. Nonspecific inhibition of the proliferative activity of keratinocytes has antidifferentiation effects that lead to defects in the barrier function and, thus, to dry, itchy, and irritable skin. These cutaneous symptoms reduce the quality of life of the patients considerably. Conditioning with topical application of niacinamide uses the cytoprotective and barrier stabilizing effect of vitamin B3. Patients and methods: A multicenter randomized crossover study investigated the influence of the test preparation on the quality of life compared to standard care for 73 patients with breast cancer undergoing adjuvant or neoadjuvant cytostatic therapy. Primary target parameter was the Dermatology Life Quality Index with its respective subscales after 6 weeks of a twice-daily application of the respective preparations. Additionally, specific symptoms such as pruritus, dryness, and

  3. Guía de actuación para el farmacéutico comunitario en pacientes con hipertensión arterial y riesgo cardiovascular: Documento de consenso

    Directory of Open Access Journals (Sweden)

    Sabater Hernández D

    2011-06-01

    Full Text Available La hipertensión arterial (HTA es un problema de salud estrechamente relacionado con un aumento del riesgo de padecer una enfermedad cardiovascular. Además, la HTA puede producir o empeorar la lesión de ciertos órganos diana, lo que también puede influir negativamente en el pronóstico cardiovascular del paciente. En España, la HTA es una condición muy frecuente, afectando a unos diez millones de sujetos adultos. Por su accesibilidad y formación especializada en materia de medicamentos, el farmacéutico comunitario puede jugar un papel clave en la detección y seguimiento del paciente con HTA. Hasta la fecha, se han publicado numerosas guías clínicas sobre la atención a pacientes con HTA, dirigidas principalmente a médicos. Sin embargo, cada vez es más evidente la necesidad de que todos los profesionales de la salud participen en la atención integral a los pacientes con HTA y riesgo cardiovascular (RCV. La cooperación entre farmacéutico, médico, personal de enfermería y otros profesionales sanitarios es imprescindible para conseguir resultados que optimicen la prevención cardiovascular y mejoren la calidad de vida del paciente. Así, a fin de promover la gestión compartida de los pacientes con HTA y RCV se publica este documento, cuyo principal destinatario es el farmacéutico comunitario. El presente documento pretende ser una herramienta de referencia que dé soporte a los programas de atención farmacéutica al paciente con HTA y RCV que se están desarrollando actualmente en las oficinas de farmacia. El texto ha sido desarrollado de forma consensuada entre expertos de la Sociedad Española de Hipertensión-Liga Española para la Lucha contra la Hipertensión Arterial (SEH-LELHA, la Sociedad Española de Farmacia Comunitaria (SEFAC y el Grupo de Investigación en Atención Farmacéutica de la Universidad de Granada (GIAF-UGR.

  4. Energy-efficiency labels and standards: A guidebook for appliances, equipment and lighting

    Energy Technology Data Exchange (ETDEWEB)

    McMahon, James E.; Wiel, Stephen

    2001-02-16

    Energy-performance improvements in consumer products are an essential element in any government's portfolio of energy-efficiency and climate change mitigation programs. Governments need to develop balanced programs, both voluntary and regulatory, that remove cost-ineffective, energy-wasting products from the marketplace and stimulate the development of cost-effective, energy-efficient technology. Energy-efficiency labels and standards for appliances, equipment, and lighting products deserve to be among the first policy tools considered by a country's energy policy makers. The U.S. Agency for International Development (USAID) and the United Nations Foundation (UNF) recognize the need to support policy makers in their efforts to implement energy-efficiency standards and labeling programs and have developed this guidebook, together with the Collaborative Labeling and Appliance Standards Program (CLASP), as a primary reference. This guidebook was prepared over the course of the past year with significant contribution from the authors and reviewers mentioned previously. Their diligent participation has made this the international guidance tool it was intended to be. The lead authors would also like to thank the following individuals for their support in the development, production, and distribution of the guidebook: Marcy Beck, Elisa Derby, Diana Dhunke, Ted Gartner, and Julie Osborn of Lawrence Berkeley National Laboratory as well as Anthony Ma of Bevilacqua-Knight, Inc. This guidebook is designed as a manual for government officials and others around the world responsible for developing, implementing, enforcing, monitoring, and maintaining labeling and standards-setting programs. It discusses the pros and cons of adopting energy-efficiency labels and standards and describes the data, facilities, and institutional and human resources needed for these programs. It provides guidance on the design, development, implementation, maintenance, and evaluation of the

  5. Adaptación española de las guías europeas de 2016 sobre prevención de la enfermedad cardiovascular en la práctica clínica

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Royo-Bordonada

    2017-05-01

    Full Text Available Las VI Guías Europeas de Prevención Cardiovascular recomiendan combinar las estrategias poblacional y de alto riesgo, con los cambios de estilo de vida como piedra angular de la prevención, y proponen la función SCORE para cuantificar el riesgo cardiovascular. Esta guía hace más hincapié en las intervenciones específicas de las enfermedades y las condiciones propias de las mujeres, las personas jóvenes y las minorías étnicas. No se recomienda el cribado de aterosclerosis subclínica con técnicas de imagen no invasivas. La guía establece cuatro niveles de riesgo (muy alto, alto, moderado y bajo, con objetivos terapéuticos de control lipídico según el riesgo. La diabetes mellitus confiere un riesgo alto, excepto en sujetos con diabetes tipo 2 con menos de 10 años de evolución, sin otros factores de riesgo ni complicaciones, o con diabetes tipo 1 de corta evolución sin complicaciones. La decisión de iniciar el tratamiento farmacológico de la hipertensión arterial dependerá del nivel de presión arterial y del riesgo cardiovascular, teniendo en cuenta la lesión de órganos diana. Siguen sin recomendarse los fármacos antiplaquetarios en prevención primaria por el riesgo de sangrado. La baja adherencia al tratamiento exige simplificar el régimen terapéutico e identificar y combatir sus causas. La guía destaca que los profesionales de la salud pueden ejercer un papel importante en la promoción de intervenciones poblacionales y propone medidas eficaces, tanto a nivel individual como poblacional, para promover una dieta saludable, la práctica de actividad física, el abandono del tabaquismo y la protección contra el abuso de alcohol.

  6. Adaptación española de la Guía Europea de Prevención Cardivascular

    Directory of Open Access Journals (Sweden)

    Carlos Brotons

    2004-01-01

    Full Text Available Presentamos la Guía europea para la prevención de las enfermedades cardiovasculares (ECV, traducida y adaptada por el Comité Español Interdisciplinario para la Prevención Cardiovascular. Esta guía se centra en la prevención de la ECV en su conjunto, recomienda el modelo SCORE para valorar el riesgo y prioriza la atención a los pacientes y sujetos de alto riesgo. El objetivo es prevenir la muerte prematura por ECV, mediante el manejo de sus factores de riesgo en la práctica clínica. Así, se requiere una intervención profesional sostenida para que los pacientes e individuos de alto riesgo incrementen su actividad física y elijan dietas cardiosaludables, y para que los fumadores abandonen el tabaco. La decisión de iniciar el tratamiento de la presión arterial dependerá de sus valores, del riesgo cardiovascular y de posibles lesiones de órganos diana. La meta terapéutica es lograr una presión arterial (140/90 mmHg, pero en pacientes con diabetes, enfermedad renal crónica, historia de ictus, enfermedad coronaria o insuficiencia cardíaca, se deben perseguir niveles inferiores. La colesterolemia debe ser menor de 200 mg/dl y el colesterol LDL menor de 130 mg/dl, aunque en pacientes con ECV o diabetes se deben perseguir niveles inferiores a 175 y 100 mg/dl, respectivamente. Un buen control de la glucemia siempre exige consejo dietético profesional. En la diabetes tipo 1 se precisa una adecuada terapia insulínica. En la diabetes tipo 2 y en los pacientes con síndrome metabólico se debe reducir el peso y aumentar la actividad física y, en su caso, aplicar fármacos. Finalmente, se incluye un anexo con recomendaciones dietéticas adaptadas a nuestro entorno y criterios de derivación o consulta con el especialista de los pacientes hipertenso y dislipémico.

  7. ADAPTACIÓN ESPAÑOLA DE LAS GUÍAS EUROPEAS DE 2016 SOBRE PREVENCIÓN DE LA ENFERMEDAD CARDIOVASCULAR EN LA PRÁCTICA CLÍNICA

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Royo-Bordonada

    2016-01-01

    Full Text Available RESUMENLas VI Guías Europeas de Prevención Cardiovascular recomiendan combinar las estrategias poblacionales y de alto riesgo, con los cambios de estilo de vida como piedra angular de la prevención, y proponen la función SCORE para cuantificar el riesgo cardiovascular. Esta guía hace más hinca-pié en las intervenciones específicas de las enfermedades y las condiciones propias de las mujeres, las personas jóvenes y las minorías étnicas. No se re-comienda el cribado de aterosclerosis subclínica con técnicas de imagen no invasivas. La guía establece cuatro niveles de riesgo (muy alto, alto, mode-rado y bajo, con objetivos terapéuticos de control lipídico según el riesgo. La diabetes mellitus confiere un riesgo alto, excepto en sujetos con diabetes tipo 2 con menos de 10 años de evolución, sin otros factores de riesgo ni complicaciones, o con diabetes tipo 1 de corta evolución sin complicacio-nes. La decisión de iniciar el tratamiento farmacológico de la hipertensión arterial dependerá del nivel de presión arterial y del riesgo cardiovascular, teniendo en cuenta la lesión de órganos diana. Siguen sin recomendarse los fármacos antiplaquetarios en prevención primaria por el riesgo de sangrado. La baja adherencia al tratamiento exige simplificar el régimen terapéutico e identificar y combatir sus causas. La guía destaca que los profesionales de la salud pueden ejercer un papel importante en la promoción de intervenciones poblacionales y propone medidas eficaces, tanto a nivel individual como poblacional, para promover una dieta saludable, la práctica de actividad fí-sica, el abandono del tabaquismo y la protección contra el abuso de alcohol

  8. Effect of fire-induced damage on the uniaxial strength characteristics of solid timber: A numerical study

    International Nuclear Information System (INIS)

    Hopkin, D J; El-Rimawi, J; Lennon, T; Silberschmidt, V V

    2011-01-01

    The advent of the structural Eurocodes has allowed civil engineers to be more creative in the design of structures exposed to fire. Rather than rely upon regulatory guidance and prescriptive methods engineers are now able to use such codes to design buildings on the basis of credible design fires rather than accepted unrealistic standard-fire time-temperature curves. Through this process safer and more efficient structural designs are achievable. The key development in enabling performance-based fire design is the emergence of validated numerical models capable of predicting the mechanical response of a whole building or sub-assemblies at elevated temperature. In such a way, efficiency savings have been achieved in the design of steel, concrete and composite structures. However, at present, due to a combination of limited fundamental research and restrictions in the UK National Annex to the timber Eurocode, the design of fire-exposed timber structures using numerical modelling techniques is not generally undertaken. The 'fire design' of timber structures is covered in Eurocode 5 part 1.2 (EN 1995-1-2). In this code there is an advanced calculation annex (Annex B) intended to facilitate the implementation of numerical models in the design of fire-exposed timber structures. The properties contained in the code can, at present, only be applied to standard-fire exposure conditions. This is due to existing limitations related to the available thermal properties which are only valid for standard fire exposure. In an attempt to overcome this barrier the authors have proposed a 'modified conductivity model' (MCM) for determining the temperature of timber structural elements during the heating phase of non-standard fires. This is briefly outlined in this paper. In addition, in a further study, the MCM has been implemented in a coupled thermo-mechanical analysis of uniaxially loaded timber elements exposed to non-standard fires. The finite element package DIANA was adopted

  9. Prevalencia de tabaquismo durante el embarazo y factores asociados en Andalucía 2007-2012

    Directory of Open Access Journals (Sweden)

    Pedro M. Mateos-Vílchez

    2014-01-01

    Full Text Available Fundamentos: El tabaquismo durante la gestación constituye el principal problema prevenible de salud perinatal. El objetivo es establecer la prevalencia de tabaquismo de las mujeres gestantes en distintos momentos del embarazo así como explorar factores asociados al mismo. Métodos: Estudio transversal. La población diana fueron las mujeres cuyo control de embarazo se realizaba en centros de salud públicos. Muestra aleatoria representativa de 40 centros estratificados según número de embarazos. Participaron 1.813 mujeres seleccionadas en 3 muestras independientes (inicio y final del embarazo y posparto. La exposición se midió mediante cotinina en orina, autodeclaración y monóxido de carbono. Se registraron variables sociodemográficas, de tabaquismo y clínico-obstétricas. Se realizó una regresión logística para identificar los factores asociados al tabaquismo. Resultados: La prevalencia media fue 21,6%, menor al final del embarazo (15,6% y en el puerperio (16,7% y mayor en el principio del embarazo (30,3%. Las mujeres fumadoras diarias pasaron del 56,3% antes del embarazo al 14% al final (autodeclaración. El 21,8% de los abandonos se produjo antes del embarazo y el 23,6% cuando las mujeres supieron que estaban embarazadas. La ocultación del consumo fue 19,6% . Fueron factores asociados ser joven (OR: 0,956; IC: 0,92-0,99, estar expuesta al tabaco en el hogar (OR: 3,48; IC: 2,6-4,7, consumo pregestacional alto (6-10 OR: 13,1 IC: 3-56,9; >10 OR: 25,1 IC: 5,8-109,6, mayor edad gestacional en la medición (al final OR: 0,5 IC: 0,4-0,8; posparto inmediato OR: 0,4 IC: 0,3-0,6 y menor nivel de estudios (sin estudios y primer grado comparadas con universitarias OR: 1,98; IC: 1,22-3,22. Conclusiones: El perfil de la mujer gestante fumadora es el de una mujer joven con bajo nivel educativo, expuesta al humo de tabaco en el hogar y con alto consumo pregestacional.

  10. Detección de Treponema pallidum subespecie pallidum para el diagnóstico de sífilis congénita mediante reacción en cadena de la polimerasa anidada.

    Science.gov (United States)

    Pinilla, Gladys; Campos, Lesly; Durán, Andrea; Navarrete, Jeannette; Muñoz, Liliana

    2018-03-15

    Introducción. La sífilis es una enfermedad producida por Treponema pallidum subespecie pallidum cuya incidencia mundial es de 12 millones de casos por año, aproximadamente; de estos, más de dos millones se presentan en mujeres gestantes, siendo la sífilis congénita la complicación más grave de esta infección en el embarazo.Objetivo. Detectar la presencia de T. pallidum subespecie pallidum en muestras clínicas para el diagnóstico de sífilis congénita mediante reacción en cadena de la polimerasa (PCR) anidada y determinar su concordancia con las pruebas serológicas.Materiales y métodos. Mediante PCR convencional y anidada, se amplificaron tres genes diana (polA, 16S ADNr y TpN47) y se confirmaron los productos de amplificación de los genes TpN47 y polA por secuenciación. Las pruebas serológicas empleadas fueron la VDRL (Venereal Disease Research Laboratory), la de reagina plasmática rápida (Rapid Plasma Reagin, RPR) y la de aglutinación de partículas para Treponema pallidum (Treponema pallidum Particle Agglutination Assay, TPPA).Resultados. La sensibilidad para la PCR convencional fue de 52 pg y, para la PCR anidada, de 0,52 pg. La especificidad con los iniciadores TpN47 y polA fue de 100 %; los resultados de la secuenciación mostraron una identidad de 97 % con T. pallidum. En 70 % de las muestras, los resultados de las pruebas serológicas y la PCR anidada concordaron.Conclusión. El gen TpN47 resultó ser el mejor blanco molecular para la identificación de T. pallidum. La PCR anidada se presenta como una alternativa de diagnóstico molecular promisoria para el diagnóstico de sífilis congénita.

  11. PREFACE: FAIRNESS 2014: FAIR Next Generation ScientistS 2014

    Science.gov (United States)

    2015-04-01

    is dedicated to the physics at FAIR. February 2015, Organizers of FAIRNESS 2014: Marco Destefanis, Tetyana Galatyuk, Fernando Montes, Diana Nicmorus, Hannah Petersen, Claudia Ratti, Laura Tolos, and Sascha Vogel. Support for holding the conference was provided by: Conference photograph

  12. PREFACE: FAIRNESS 2013: FAIR NExt generation of ScientistS 2013

    Science.gov (United States)

    Petersen, Hannah; Destefanis, Marco; Galatyuk, Tetyana; Montes, Fernando; Nicmorus, Diana; Ratti, Claudia; Tolos, Laura; Vogel, Sascha

    2014-04-01

    research that is dedicated to the physics of FAIR. February 2014. Organizers of FAIRNESS 2013: Marco Destefanis, Tetyana Galatyuk, Fernando Montes, Diana Nicmorus, Hannah Petersen, Claudia Ratti, Laura Tolos, and Sascha Vogel. Support for holding the conference was provided by: Logos

  13. The reliability of lung ultrasound in assessment of idiopathic pulmonary fibrosis

    Directory of Open Access Journals (Sweden)

    Manolescu D

    2018-03-01

    Full Text Available Diana Manolescu,1 Lavinia Davidescu,2 Daniel Traila,3 Cristian Oancea,3 Voicu Tudorache3 1Radiology Department, University of Medicine and Pharmacy “Victor Babes”, Timişoara, Romania; 2Department of Pulmonology, University of Medicine and Pharmacy Oradea, Oradea, Romania; 3Department of Pulmonology, University of Medicine and Pharmacy “Victor Babes”, Timişoara, Romania Abstract: Idiopathic pulmonary fibrosis (IPF is the severest form of idiopathic interstitial pneumonia, with a median survival time estimated at 2–5 years from the time of diagnosis. It occurs mainly in elderly adults, suggesting a strong link between the fibrosis process and aging. Although chest high-resolution computed tomography (HRCT is currently the method of choice in IPF assessment, diagnostic imaging with typical usual interstitial pneumonia (UIP provides definitive results in only 55%, requiring an invasive surgical procedure such as lung biopsy or cryobiopsy for the final diagnostic analysis. Lung ultrasound (LUS as a noninvasive, non-radiating examination is very sensitive to detect subtle changes in the subpleural space. The evidence of diffuse, multiple B-lines defined as vertical, hyperechoic artifacts is the hallmark of interstitial syndrome. A thick, irregular, fragmented pleura line is associated with subpleural fibrotic scars. The total numbers of B-lines are correlated with the extension of pulmonary fibrosis on HRCT, being an LUS marker of severity. The average distance between two adjacent B-lines is an indicator of a particular pattern on HRCT. It is used to appreciate a pure reticular fibrotic pattern as in IPF compared with a predominant ground glass pattern seen in fibrotic nonspecific interstitial pattern. The distribution of the LUS artifacts has a diagnostic value. An upper predominance of multiple B-lines associated with the thickening of pleura line is an LUS feature of an inconsistent UIP pattern, excluding the IPF diagnosis. LUS is a

  14. Antidepressant exposure in pregnancy and risk of autism spectrum disorders

    Directory of Open Access Journals (Sweden)

    Sørensen MJ

    2013-11-01

    Full Text Available Merete Juul Sørensen,1 Therese Koops Grønborg,2 Jakob Christensen,3,4 Erik Thorlund Parner,2 Mogens Vestergaard,5,6 Diana Schendel,7 Lars Henning Pedersen8,9 1Regional Centre of Child and Adolescent Psychiatry, Aarhus University Hospital, Risskov, Denmark; 2Department of Public Health, Section of Biostatistics, Aarhus University, Aarhus, Denmark; 3Department of Neurology, Aarhus University Hospital, Aarhus, Denmark; 4Department of Clinical Pharmacology, 5Department of Public Health, Section of General Practice, 6Research unit for General Practice, Aarhus University, Aarhus, Denmark; 7Centers for Disease Control and Prevention, Atlanta, GA, USA; 8Danish Epidemiological Science Centre, Institute of Public Health, 9Department of Obstetrics and Gynecology, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark Background: Both the use of antidepressant medication during pregnancy and the prevalence of autism spectrum disorder have increased during recent years. A causal link has recently been suggested, but the association may be confounded by the underlying indication for antidepressant use. We investigated the association between maternal use of antidepressant medication in pregnancy and autism, controlling for potential confounding factors. Methods: We identified all children born alive in Denmark 1996–2006 (n=668,468 and their parents in the Danish Civil Registration System. We obtained information on the mother's prescriptions filled during pregnancy from the Danish National Prescription Registry, and on diagnoses of autism spectrum disorders in the children and diagnoses of psychiatric disorders in the parents from the Danish Psychiatric Central Register. In a cohort analysis, we estimated hazard ratios of autism spectrum disorders in children exposed to antidepressant medication during pregnancy compared with children who were not exposed, using Cox proportional hazards regression analysis. Furthermore, we estimated the risk

  15. Nationwide trends in glucose-lowering drug use, Denmark, 1999–2014

    Directory of Open Access Journals (Sweden)

    Christensen DH

    2016-10-01

    Full Text Available Diana Hedevang Christensen,1 Jørgen Rungby,2,3 Reimar Wernich Thomsen1 1Department of Clinical Epidemiology, Aarhus University Hospital, Denmark; 2Department of Pharmacology, University of Aarhus, Aarhus, Denmark; 3Department of Endocrinology, Gentofte University Hospital, Copenhagen, Denmark Purpose: The objective of this study was to examine nationwide population-based time trends in the utilization of all glucose-lowering drugs in Denmark from 1999 to 2014. Methods: Based on nationwide data from the Register of Medicinal Products Statistics, we retrieved sales statistics on glucose-lowering drugs and reported the total number of users and the prevalence of users per 1,000 inhabitants in 1-year intervals for all glucose-lowering drug classes. Results: The annual prevalence of glucose-lowering drug users increased more than twofold from 19 per 1,000 inhabitants in 1999 (n=98,362 to 41 per 1,000 in 2014 (n=233,230. Metformin use increased more than sevenfold during the period and was used by 30 of 1,000 inhabitants in 2014, while the prevalence of insulin use increased 1.8-fold to 13 per 1,000 in 2014. After peaking in 2007, use of sulfonylurea halved to 6 per 1,000 in 2014. Newer drug classes including the glucagon-like peptide 1 receptor agonists, the dipeptidylpeptidase-4 inhibitors, and the sodium–glucose cotransporter 2 inhibitors had reached a considerable position by 2014, with 4 per 1,000, 6 per 1,000, and 0.8 per 1,000 inhabitants, respectively; however, the use of glucagon-like peptide 1 receptor agonists and sodium–glucose cotransporter 2 inhibitors in elderly people remained low. Thiazolidinediones decreased to virtually no use (0.03 per 1,000 in 2014. Conclusion: The use of glucose-lowering drugs has doubled during 1999–2014. The pattern of glucose-lowering drug use has changed substantially reflecting the recommendations of metformin as first-line treatment. The newer glucose-lowering drug classes have been well received

  16. Aplicación del Láser Escáner Terrestre (TLS a la modelización de estructuras: precisión, exactitud y diseño de la adquisición de datos en casos reales

    Directory of Open Access Journals (Sweden)

    Ramos, L.

    2015-06-01

    Full Text Available Terrestrial laser scanner is employed in a wide range of engineering applications, because of the specifications of TLS units and the good precision reached. This paper presents the application of TLS to structures and walls modeling. It analyzes the factors that influence final accuracy: cloud registration, target type and the effect of scanning angle and distance. A field test was performed with calibrated panels, obtaining real precision and accuracy values for the most common distance ranges in engineering. We propose and validate the usage of pattern graphs relating precision and accuracy versus distance and scanning angle for field survey design. The application of pattern graph in the design of field scan surveys for dam movement control is also presented. Recommendations are made for the application of TLS technique to large structures.El láser escáner terrestre se emplea en numerosas aplicaciones de Ingeniería, debido a las prestaciones de los equipos y a las precisiones alcanzadas. Se presenta la aplicación del TLS a la modelización de estructuras y paramentos verticales. Se analizan los factores que influyen en la precisión final: registro de nubes, tipo de dianas y el efecto del ángulo y distancia de escaneo. Se realizó una prueba de campo con testigos calibrados, obteniendo valores reales de precisión y exactitud para los rangos de distancia más usuales en Ingeniería. Se propone y valida el empleo de gráficos patrón que relacionan las variables precisión y exactitud con los factores distancia y ángulo de escaneo para el diseño de trabajos de campo. Se expone su aplicación al diseño de los escaneos para el control de movimientos de una presa. Se realizan recomendaciones para la aplicación de la técnica TLS a grandes estructuras.

  17. FAIRNESS 2016 [4. workshop for young scientists with research interests focused on physics at FAIR (Facility for Antiproton and Ion Research), Garmisch-Partenkirchen (Germany), 14-19 Feb 2016

    International Nuclear Information System (INIS)

    2016-01-01

    physics at FAIR. June 2016, Organizers of FAIRNESS 2016: Marco Destefanis, Tetyana Galatyuk, Fernando Montes, Diana Nicmorus, Claudia Ratti, and Laura Tolos. (paper)

  18. Conocimientos de la población sobre lepra Knowledge of the population about leprosy

    Directory of Open Access Journals (Sweden)

    Isora Montenegro Valera

    2006-12-01

    Full Text Available Se realizó un estudio observacional descriptivo de tipo transversal para investigar el nivel de conocimientos, que sobre la lepra, tiene la población en el municipio de Limonar, durante el período de Marzo a Diciembre de 2002. Participaron en el estudio 395 pacientes mayores de 15 años, que fueron seleccionados de la población del municipio mediante un diseño multietápico que incluyó la estratificación y el conglomerado. Los datos fueron procesados en el sistema estadístico SPSS-10. Se utilizaron técnicas estadísticas como el Chi cuadrado para explorar la asociación significativa entre variables. Se obtuvo como resultado que existe desconocimiento por parte de la población acerca de la enfermedad, ya que solamente el 17,97 % de la población mostró conocimientos adecuados, y se encontró relación significativa entre este, el sexo femenino y la escolaridad. Sobre la base de los resultados se recomiendan las audiencias diana para una efectiva intervención educativa en la Atención Primaria de Salud en este municipio.An observational, descriptive and cross-sectional study was undertaken to investigate the level of knowledge of the population about leprosy in Limonar municipality from March to December, 2002. 395 patients over 15 participated in the study. They were selected from the population of the municipality by a multistage design that included stratification and cluster. The data were processed by the SPSS-10 statistical system. Statistical techniques as the Chi square test were used to explore the significant association among the variables. It was concluded that there is lack of knowledge about the disease, since only 17.97 % of the population showed an adequate knowledge. A significant relation was found among knowledge, the female sex and the educational level. According to these results, the target hearings are recommended for an effective educative intervention at the primary health care level in this municipality.

  19. Conocimientos de los médicos de familia sobre lepra Knoledge of the family physicians about leprosy

    Directory of Open Access Journals (Sweden)

    Isora Montenegro Valera

    2006-09-01

    Full Text Available Se realizó un estudio observacional descriptivo de tipo transversal para investigar el nivel de conocimientos de los Médicos de Familia sobre la lepra en el municipio de Limonar, durante el período de marzo a diciembre de 2002. Participaron en el estudio 36 Médicos de Familia de consultorios pertenecientes al Policlínico Docente “Nelson Fernández” de Limonar. Los datos fueron procesados en el sistema estadístico SPSS-10. Se utilizaron técnicas estadísticas como el cálculo del Chi cuadrado y la prueba de Kruskall Wallis para explorar la asociación significativa entre variables y comparar promedios entre muestras independientes. Se obtuvo como resultado que existe desconocimiento por parte de los Médicos de Familia acerca de la enfermedad, ya que solamente la cuarta parte de ellos alcanzó la puntuación mínima indispensable considerada para realizar un diagnóstico y tratamiento correcto de la enfermedad. Se demostró la importancia de la especialización de los médicos en la consolidación y enriquecimiento de los conocimientos relacionados con esta enfermedad y su declinación con el decursar de los años de graduado. En base a los resultados se recomendaron las audiencias diana para una efectiva intervención educativa en la Atención Primaria de Salud en este municipio.An observational descriptive cross-sectional study was conducted to investigate the level of knowledge of the family physicians about leprosy in Limonar municipality from March to December, 2002. 36 family physicians from the offices corresponding to "Nelson Fernández" Teaching Polyclinic, in Limonar, participated in the study. Data were processed by the SPSS-10 statistical system. Statistical tests as the chi square test and Kruskall Wallis' test were used to explore the significant association between the variables and to compare averages among independent samples. It was found that there exists lack of knowledge about the disease, since only a fourth of

  20. Factores asociados al consumo de tabaco en una población de adultos Risk factors associated with tobacco consumption in an adult population

    Directory of Open Access Journals (Sweden)

    Virginia Corina Samaniego

    2005-12-01

    Full Text Available Esta investigación se planteó identificar factores asociados a la adicción al tabaco. El abordaje se basó en una articulación entre el paradigma transteorético de Prochaska y la perspectiva comunitaria de la salud pública. El universo lo constituyeron los integrantes de escuelas estatales para adultos del Partido de Avellaneda, Provincia de Buenos Aires. El total de la muestra fue de 888 sujetos. Se trabajó por censo. Se evaluaron los factores que se asociaban al consumo de tabaco en la población diana y de las variables que definían la fase en que se encontraban los sujetos según el modelo Transteorético de Prochaska. En nuestra población a diferencia de lo encontrado por Prochaska, existe una proporción mayor de sujetos en etapa de precontemplación (51,8%. Además, dentro del síndrome de abstinencia, predomina el síntoma de ansiedad. Por último, son las situaciones de afecto negativo las que provocan mayor tentación de fumar.The aim of this research was to identify the risk factors associated with tobacco addiction in an adult popu-lation. It was the first stage of a broader intervention field study. It was based in the articulation between the Transtheoretical Model of Change of Prochaska and the Public Health Community Perspective. The population were members of Public Schools for adults settled on the Avellaneda's district, in Buenos Aires province, 888 individuals composed the whole sample. We worked by census. A meaningful result is that in our population there is a bigger proportion of individuals in the Precontemplation stage (51,8% than in the U.S.A. Prochaska had demonstrated that approximately 40% of smokers were in this stage in that country. Another finding has been that within the abstinence syndrome, the anxiety symptom prevails. Lastly, negative emotion situations are the ones that tempts people to smoke more.