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Sample records for aimar rakko diana

  1. Diana Leonard and Materialist Feminism

    Science.gov (United States)

    Jackson, Stevi

    2013-01-01

    This tribute to Diana Leonard focuses on her contribution to materialist feminism, both through bringing the work of key French theorists to the attention of an Anglophone audience and through her own sociological work on the family, marriage and childhood. In so doing it draws attention to the importance of her work as editor and…

  2. Diana Al-Hadid: Identity and Heritage

    Science.gov (United States)

    Jungerberg, Tom; Smith, Anna; Borsh, Colleen

    2012-01-01

    Diana Al-Hadid's sculptures reflect the many locations, cultures, histories, and mythologies that have shaped her as an artist. In large-scale works which have the appearance of architectural ruins, Al-Hadid employs imagery drawn from many diverse interests including science and technology, history, and literature. She also incorporates images and…

  3. Diana Bellessi: la voz de lo amado

    OpenAIRE

    Melchiorre, Valeria

    2012-01-01

    El título de la presente ponencia, « La voz de lo amado », está tomado del de un poema de Diana Bellessi incluido en su libro La rebelión del instante. El sintagma pretende sintetizar el objeto de nuestro estudio : la manera en que la voz poética se constituye para dar cabida a lo amado, y los modos de aparición de lo amado, en sus diferentes versiones, en la poesía última de Bellessi.Aunque no faltarán algunas referencias a Variaciones de la luz, que la editorial « bajo la luna » publicó est...

  4. Diana Bellessi: la voz de lo amado

    Directory of Open Access Journals (Sweden)

    Valeria Melchiorre

    2007-07-01

    Full Text Available El título de la presente ponencia, « La voz de lo amado », está tomado del de un poema de Diana Bellessi incluido en su libro La rebelión del instante. El sintagma pretende sintetizar el objeto de nuestro estudio : la manera en que la voz poética se constituye para dar cabida a lo amado, y los modos de aparición de lo amado, en sus diferentes versiones, en la poesía última de Bellessi.Aunque no faltarán algunas referencias a Variaciones de la luz, que la editorial « bajo la luna » publicó est...

  5. Modno vsjo! Nosim to, tshto k litsu / Diana Denissova

    Index Scriptorium Estoniae

    Denissova, Diana

    2006-01-01

    Moskva moenädalal näidatud kollektsioonidest. Oma moekollektsioone esitlesid Valentin Judashkin, Igor Saruhhanov, Masha Tsigal, Natasha Glazkova, Diana Dorozhkina, Svetlana Tegin, Liza Romanjuk, Jelena Tshekrizova, Darja Razumihhina, Vjatsheslav Zaitsev

  6. Diana H. Wall, ESA President 1999-2000

    Science.gov (United States)

    Baron, Jill S.; Parsons, A.

    2000-01-01

    A more polite term for workaholic is over-achiever, and Diana Harrison Wall could easily serve as the type specimen for both words. Her ability to multi-task is a great boon for the Ecological Society of America. That characteristic drive has also been essential to Wall’s own personal success, since it pushed her to persevere during the lean years when a woman’s place was NOT in the field or laboratory. Diana is a very strong role model for young ecologists through her enthusiasm for science, her remarkable scientific achievements, and her leadership skills. In addition to advising her many graduate students, Diana-as-role-model has been featured in many news media, including PBS TV shows such as “Horizons” and “Discovery,” National Geographic magazine, and the New York Times. She is highlighted on the ESA Web site: “What Do Ecologists Do? Focus on Ecologists.”

  7. Data analysis with the DIANA meta-scheduling approach

    International Nuclear Information System (INIS)

    Anjum, A; McClatchey, R; Willers, I

    2008-01-01

    The concepts, design and evaluation of the Data Intensive and Network Aware (DIANA) meta-scheduling approach for solving the challenges of data analysis being faced by CERN experiments are discussed in this paper. Our results suggest that data analysis can be made robust by employing fault tolerant and decentralized meta-scheduling algorithms supported in our DIANA meta-scheduler. The DIANA meta-scheduler supports data intensive bulk scheduling, is network aware and follows a policy centric meta-scheduling. In this paper, we demonstrate that a decentralized and dynamic meta-scheduling approach is an effective strategy to cope with increasing numbers of users, jobs and datasets. We present 'quality of service' related statistics for physics analysis through the application of a policy centric fair-share scheduling model. The DIANA meta-schedulers create a peer-to-peer hierarchy of schedulers to accomplish resource management that changes with evolving loads and is dynamic and adapts to the volatile nature of the resources

  8. Mis hoiab meid kukkumast? / Diana Leesalu ; intervjueerinud Triin Sinissaar

    Index Scriptorium Estoniae

    Leesalu, Diana

    2011-01-01

    EMTA Lavakunstikooli 3. kursusel dramaturgiks õppiv Diana Leesalu rootsi näitekirjaniku Johanna Emanuelssoni näidendi "Vaata, ma kukun" lavastamisest Tallinna Linnateatris, lavastusest. Kunstnik Kaspar Jancis. Mängivad lavakunstikooli üliõpilased ja Tallinna Linnateatri näitlejad

  9. Success: Richard Dyer on Diana Ross [and Beyond

    NARCIS (Netherlands)

    Kooijman, J.

    2016-01-01

    In June 1982, film scholar Richard Dyer published a two-page essay on African-American star Diana Ross in the journal Marxism Today. Part of Dyer’s essay focuses on the American conception of success and specifically on how Ross is one of the few black artists who has been "allowed" to be such a

  10. Interview with Contemporary Armenian Writer and Translator Diana Hambardzumyan

    Directory of Open Access Journals (Sweden)

    Beatrice Tottossy

    2016-12-01

    Full Text Available A conversation with Diana Hambardzumyan, a contemporary Armenian writer, translator and lecturer in English Literature at the University of Yerevan, foregrounds a series of significant features of contemporary Armenian literature and the country’s key social and cultural issues. She interconnects current events with the literary memory, highlighting and confirming the Armenian writers’ need to maintain their traditional role as representatives of the cultural will of their people.

  11. IDENTIFICATION OF MYCOBACTERIUM GENAVENSE IN A DIANA MONKEY (CERCOPITHECUS DIANA) BY POLYMERASE CHAIN REACTION AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY.

    Science.gov (United States)

    Kelly, Kathleen M; Wack, Allison N; Bradway, Dan; Simons, Brian W; Bronson, Ellen; Osterhout, Gerard; Parrish, Nicole M; Montali, Richard J

    2015-06-01

    A 25-yr-old Diana monkey (Cercopithecus diana) with a 1.5-yr history of chronic colitis and diarrhea was found to have disseminated granulomatous disease with intralesional acid fast bacilli. Bacilli were identified as Mycobacterium genavense by polymerase chain reaction, sequencing of the 16S-23S ribosomal RNA intergenic spacer (ITS) gene, and mycolic acid analysis by high-performance liquid chromatography. Mycobacterium genavense is a common cause of mycobacteriosis in free-ranging and captive birds. In addition, recognition of opportunistic infection in human immunodeficiency virus-positive patients is increasing. Disease manifestations of M. genavense are similar to Mycobacterium avium complex (MAC) and include fever, wasting, and diarrhea with disseminated disease. Similar clinical signs and lesions were observed in this monkey. Mycobacterium genavense should be considered as a differential for disseminated mycobacterial disease in nonhuman primates as this agent can mimic MAC and related mycobacteria.

  12. Tamarugite from Diana Cave (SW Romania) -first true karst occurrence

    Science.gov (United States)

    Pušcaš, C. M.; Onac, B. P.; Effenberger, H. S.; Povarǎ, I.

    2012-04-01

    Diana Cave is located within the town limits of Baile Herculane (SW Romania) and develops as a 14 m long, westward oriented, unique passage guided by the Diana fault [1]. At the far end of the cave, the thermo-mineral Diana Spring wells forth. In the early 1970s a mine gallery that intersected the cave was created to drain the water into a pumping station and the original cave passage was somewhat altered and reinforced with concrete. Today the concrete and the silty limestone cave walls are heavily corroded by H2SO4 outgassing from the hot water (ca. 50°C) and display abundant gypsum crusts, soggy aggregates of native S, and a variety of more exotic sulfates. Among them, a mineral that has been previously identified in caves only in connection to volcanic activity, either as thermal springs or fumaroles [2]: tamarugite [NaAl(SO4)26H2O]. It was [3] that first mentioned the occurrence of this Na and Al sulfate in Diana Cave, our research aiming to give a detailed description of this mineral, its paragenesis, and mechanisms of precipitation. Recently, tamarugite has also been identified in a sulfuric acid cave from Greece [4]. Along with powder X-ray diffractions coupled with Rietveld refinement, scanning electron microscope, and electron probe micro-analysis, δ18O and δ34S compositions of the sulfate mineral as well as precipitates from the water were analyzed to identify and better constrain the genesis of this rare sulfate. Regrettably, the crystal size of our specimens is inappropriate for identification by means of single crystal X-ray diffraction. Physical and chemical parameters of Diana Spring were as well measured on several occasions. Geochemical analysis suggests that the minute, white tamarugite flakes precipitated in Diana Cave as a result of the interactions between the thermo-mineral water or water vapor and the original limestone bedrock and concrete that blankets the mine gallery. [1] Povara, I., Diaconu, G., Goran, C. (1972). Observations pr

  13. Surveillance and Social Memory: Remembering Princess Diana with CCTV

    Directory of Open Access Journals (Sweden)

    Nicole Falkenhayner

    2016-09-01

    Full Text Available Since the 1990s, surveillance camera images have experienced a function creep from their juridical uses into journalism and entertainment. In these contexts, the images have also become memory media. This article, for the first time, analyses CCTV images, meaning closed circuit surveillance camera images, as memory media and discusses the implications of our use of artefacts of control within a frame of mediated constructions of social memory. The article undertakes this work by analyzing remediations of the CCTV images of Diana Spencer and Dodi Al-Fayed in the Ritz Hotel in Paris on 30 August 1997 in television news and a documentary from 2007 and 2011, respectively. It is shown how social memory of Diana’s death is a contested site, in which the images play a specific role.

  14. ''DIANA'' - A New, Deep-Underground Accelerator Facility for Astrophysics Experiments

    International Nuclear Information System (INIS)

    Leitner, M.; Leitner, D.; Lemut, A.; Vetter, P.; Wiescher, M.

    2009-01-01

    The DIANA project (Dakota Ion Accelerators for Nuclear Astrophysics) is a collaboration between the University of Notre Dame, University of North Carolina, Western Michigan University, and Lawrence Berkeley National Laboratory to build a nuclear astrophysics accelerator facility 1.4 km below ground. DIANA is part of the US proposal DUSEL (Deep Underground Science and Engineering Laboratory) to establish a cross-disciplinary underground laboratory in the former gold mine of Homestake in South Dakota, USA. DIANA would consist of two high-current accelerators, a 30 to 400 kV variable, high-voltage platform, and a second, dynamitron accelerator with a voltage range of 350 kV to 3 MV. As a unique feature, both accelerators are planned to be equipped with either high-current microwave ion sources or multi-charged ECR ion sources producing ions from protons to oxygen. Electrostatic quadrupole transport elements will be incorporated in the dynamitron high voltage column. Compared to current astrophysics facilities, DIANA could increase the available beam densities on target by magnitudes: up to 100 mA on the low energy accelerator and several mA on the high energy accelerator. An integral part of the DIANA project is the development of a high-density super-sonic gas-jet target which can handle these anticipated beam powers. The paper will explain the main components of the DIANA accelerators and their beam transport lines and will discuss related technical challenges

  15. "DIANA" - A New, Deep-Underground Accelerator Facility for Astrophysics Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Leitner, M.; Leitner, D.; Lemut, A.; Vetter, P.; Wiescher, M.

    2009-05-28

    The DIANA project (Dakota Ion Accelerators for Nuclear Astrophysics) is a collaboration between the University of Notre Dame, University of North Carolina, Western Michigan University, and Lawrence Berkeley National Laboratory to build a nuclear astrophysics accelerator facility 1.4 km below ground. DIANA is part of the US proposal DUSEL (Deep Underground Science and Engineering Laboratory) to establish a cross-disciplinary underground laboratory in the former gold mine of Homestake in South Dakota, USA. DIANA would consist of two high-current accelerators, a 30 to 400 kV variable, high-voltage platform, and a second, dynamitron accelerator with a voltage range of 350 kV to 3 MV. As a unique feature, both accelerators are planned to be equipped with either high-current microwave ion sources or multi-charged ECR ion sources producing ions from protons to oxygen. Electrostatic quadrupole transport elements will be incorporated in the dynamitron high voltage column. Compared to current astrophysics facilities, DIANA could increase the available beam densities on target by magnitudes: up to 100 mA on the low energy accelerator and several mA on the high energy accelerator. An integral part of the DIANA project is the development of a high-density super-sonic gas-jet target which can handle these anticipated beam powers. The paper will explain the main components of the DIANA accelerators and their beam transport lines and will discuss related technical challenges.

  16. The AIMAR recommendations for early diagnosis of chronic obstructive respiratory disease based on the WHO/GARD model*

    Science.gov (United States)

    2014-01-01

    the Italian context; the document of the Agency for Regional Healthcare Services (AGE.NA.S) is a more suited compendium for consultation, and the recent joint statement on integrated COPD management of the three major Italian scientific Associations in the respiratory area together with the contribution of a Society of General Medicine deals prevalently with some critical issues (appropriateness of diagnosis, pharmacological treatment, rehabilitation, continuing care); also the document “Care Continuity: Chronic Obstructive Pulmonary Disease (COPD)” of the Global Alliance against chronic Respiratory Diseases (GARD)-Italy does not treat in depth the issue of early diagnosis. The present document – produced by the AIMAR (Interdisciplinary Association for Research in Lung Disease) Task Force for early diagnosis of chronic respiratory disease based on the WHO/GARD model and on available evidence and expertise –after a general examination of the main epidemiologic aspects, proposes to integrate the above-mentioned existing documents. In particular: a) it formally indicates on the basis of the available evidence the modalities and the instruments necessary for carrying out secondary prevention at the primary care level (a pro-active,‘case-finding’approach; assessment of the individual’s level of risk of COPD; use of short questionnaires for an initial screening based on symptoms; use of simple spirometry for the second level of screening); b) it identifies possible ways of including these activities within primary care practice; c) it places early diagnosis within the “systemic”, consequential management of chronic respiratory diseases, which will be briefly described with the aid of schemes taken from the Italian and international reference documents. PMID:25473523

  17. New host and the extend of the host range of warble fly Hypoderma diana (Diptera, Hypodermatidae

    Directory of Open Access Journals (Sweden)

    Pavlásek Ivan

    2014-03-01

    Full Text Available Warble fly Hypoderma diana is known to be a parasite not only of roe deer and other species of Cervidae but also of non-specific hosts from among other orders of ungulates. First-instar larvae of Hypoderma diana, a specific parasite of Cervidae, have been found in a new non-specific host, i.e. the wild boar (Sus scrofa. This finding is further evidence of the exceptional adaptability of this species of subcutaneous warble fly of the family Hypodermatidae. It corroborates the validity of the proposition that the host range of a host-specific parasite can only be ext

  18. Popmuusika / Aimar Ventsel

    Index Scriptorium Estoniae

    Ventsel, Aimar, 1970-

    2006-01-01

    Uutest heliplaatidest Amparanoia "La Vida Te Da", "Kui lähed, mine iseendasse", Cyantific "Ghetto Blaster", The Like "Are You Thinkingb What I'm Thinking?", Prince "3121", Lordi "The Arockalypse", "Twisted Disco"

  19. Muusika / Aimar Ventsel

    Index Scriptorium Estoniae

    Ventsel, Aimar, 1970-

    2005-01-01

    Uutest heliplaatidest "Sandra Sillamaa", "The Concretes", The Juan Maclean "Less Than Human", Joni Mitchell "Songs Of A Prairie Girl", Pedegree "Growing Apart", Shelton San "EP", The Five Corners Quintet "Chasin' The Jazz Gone By", "The Story of Popular Black Music", Foo Fighters "In Your Honor", A "Teen Dance Ordinance"

  20. DIANA-microT web server: elucidating microRNA functions through target prediction.

    Science.gov (United States)

    Maragkakis, M; Reczko, M; Simossis, V A; Alexiou, P; Papadopoulos, G L; Dalamagas, T; Giannopoulos, G; Goumas, G; Koukis, E; Kourtis, K; Vergoulis, T; Koziris, N; Sellis, T; Tsanakas, P; Hatzigeorgiou, A G

    2009-07-01

    Computational microRNA (miRNA) target prediction is one of the key means for deciphering the role of miRNAs in development and disease. Here, we present the DIANA-microT web server as the user interface to the DIANA-microT 3.0 miRNA target prediction algorithm. The web server provides extensive information for predicted miRNA:target gene interactions with a user-friendly interface, providing extensive connectivity to online biological resources. Target gene and miRNA functions may be elucidated through automated bibliographic searches and functional information is accessible through Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. The web server offers links to nomenclature, sequence and protein databases, and users are facilitated by being able to search for targeted genes using different nomenclatures or functional features, such as the genes possible involvement in biological pathways. The target prediction algorithm supports parameters calculated individually for each miRNA:target gene interaction and provides a signal-to-noise ratio and a precision score that helps in the evaluation of the significance of the predicted results. Using a set of miRNA targets recently identified through the pSILAC method, the performance of several computational target prediction programs was assessed. DIANA-microT 3.0 achieved there with 66% the highest ratio of correctly predicted targets over all predicted targets. The DIANA-microT web server is freely available at www.microrna.gr/microT.

  1. U-Pb age of the Diana Complex and Adirondack granulite ...

    Indian Academy of Sciences (India)

    Granulites; geochronology; petrogenesis; Adirondacks; zircon age. ... The 1118 Ma age for the Diana Complex, some 35 Ma younger than previously believed, is now approximately synchronous with the main Adirondack anorthosite intrusion, ... U.S. Geological Survey, MS 963, Federal Center, Denver, CO 80225,USA.

  2. U-Pb age of the Diana Complex and Adirondack granulite ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    the Adirondack dome (figure 1a) exposes a sec- tion of the ... land et al 1988; McLelland and Chiarenzelli 1989,. 1990 .... lands. The Diana pyroxene syenites may belong to the charnockitic or mangeritic rock series sur- rounding the main anorthosite massifs in the high- lands as suggested by DeWaard (1969), although.

  3. DIANA and applications to fermion production in electron-positron annihilation

    International Nuclear Information System (INIS)

    Fleischer, J.; Lorca, A.; Tentyukov, M.

    2004-01-01

    A demonstration of the use of DIANA has been given. As an example, the process e+e-->tt-bar was selected. Recent developments are indicated: automation of momenta distribution, the status of parallelization of FORM jobs, handling of topologies and new features for the implementation of fermions

  4. Condolence Books: Language and Meaning in the Mourning for Hillsborough and Diana

    Science.gov (United States)

    Brennan, Michael

    2008-01-01

    This article reports empirical research into public books of condolence signed following two key mourning events within British culture: the 1989 Hillsborough soccer stadium disaster and the death of Diana, Princess of Wales, in 1997. The author suggests that not only do condolence books provide valuable historical record of the way contemporary…

  5. Mida ootavad juhid oma kommunikatsioonipartnerilt? / Diana Veigel, Kristina Laaneots, Reelika Jakubovski ; intervjueerinud Annela Laaneots

    Index Scriptorium Estoniae

    Veigel, Diana

    2016-01-01

    Oma mõtteid koostööst kommunikatsioonipartneritega jagasid intervjuus Statoil Fuel & Retail Eesti AS-i turundusdirektor Diana Veigel, DHL Expressi äriüksuse tegevjuht Eestis Kristina Laaneots ja Luisa Tõlkebüroo juhatuse liige Reelika Jakubovski

  6. Tamarugite in the Steam-Condensate Alteration Paragenesis in Diana Cave (SW Romania)

    Science.gov (United States)

    Puscas, C. M.; Onac, B. P.; Effenberger, H. S.; Povară, I.

    2012-12-01

    The double-salt hydrate tamarugite [NaAl(SO4)2 6H2O] is an uncommon mineral in the cave environment, forming as a result of chemical reactions between water and bedrock only under very specific conditions. The Diana Cave hosts a unique tamarugite occurrence, the first one to be reported from a typical karst environment. The cave is located within the limits of Băile Herculane township in the Cerna Mountains, SW Romania. It consists of a 14 m long, westward-oriented single passage, developed along the Diana Fault. In 1974 a concrete-clad mine gallery was created to channel the thermal water (Diana 1+2 Spring) flowing through the cave to a pumping station. The spring's chemical and physical parameters fluctuated through time, averaging 51.98° C, discharge of 0.96 Ls-1, pH of 7.46, 5768.66 ppm TDS, 9303 μScm-1 conductivity, 5.02 salinity. The major chemical components of the thermo-mineral water in Diana Cave are, Na+ (1392.57 ppm), K+ (58.55 ppm), Ca2+ (725.16 ppm), Mg2+ (10.78 ppm), Cl- (3376.83 ppm), and SO42- (92.27 ppm), and H2S (24.05 ppm), with traces of Si, Fe2+, Br+, I-, and Li+. The general air circulation pattern within the cave is fairly simple: cold air from the outside sweeps into the cave along the floor, heats up at the contact with the thermo-mineral water, ascends, and exists the cave along the ceiling. At the contact with the cold walls of the Diana Cave, the hot steam condenses and gives rise to a rich and exotic sulfate-mineral paragenesis (including halotrichite-series minerals, gypsum, bassanite, anhydrite, epsomite, alunite, halite, native sulfur, etc.). The most exotic minerals precipitate at or below the contact between the Tithonic - Neocomian limestone and the overlaying Cretaceous shaly limestone, as a result of steam-condensate alteration. Minerogenetic mechanisms responsible for the peculiar sulfate mineral assemblage in Diana Cave are evaporation, oxidation, hydrolysis, double exchange reactions, and deposition from vapours or

  7. [DianaWeb: a demonstration project to improve breast cancer prognosis through lifestyles].

    Science.gov (United States)

    Villarini, Anna; Villarini, Milena; Gargano, Giuliana; Moretti, Massimo; Berrino, Franco

    2015-01-01

    In the field of cancer prevention, the public ask to be involved more actively in scientific research and in the production of knowledge. This is leading to an increase of participatory projects in the field of epidemiology. Community-based participatory research (CBPR) has received considerable attention in the past 15 years; it is becoming a recognized and important approach in addressing health disparities in cancer prevention. The increasing accessibility of new methods of comparison, discussion and information allows to link a large number of people. The project DianaWeb was born in 2015 at the Department of Predictive Medicine and Prevention of the National Cancer Institute, Milan. This CBPR involves women with diagnosis of breast cancer (BC). DianaWeb communications are based on an interactive online platform developed "ad hoc" (www.dianaweb.org). With very few exceptions, all communication between participants and research team will be on the web. The recruitment is done through Internet, hospitals, physicians, media and word of mouth. Women can join the project independently, under the control of researchers and the aim of the study is to assess whether healthy eating and regular physical activity can improve the quality of life and increase survival rates in women with diagnosis of BC. About 50,000 Italian women with a diagnosis of BC with or without metastasis, local recurrence or second cancers; with in situ or invasive cancer, whatever the disease stage at diagnosis, whatever histological diagnosis, whatever the time elapsed since diagnosis should be recruited in the DianaWeb project. The volunteers are asked to send clinical information about their condition from diagnosis onwards, on their weight and other anthropometric measures, lifestyles and nutrition through online questionnaires. Moreover, the women enrolled in the study, after login, can access evidence-based information and results obtained during the project (individual and whole community

  8. DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows.

    Science.gov (United States)

    Paraskevopoulou, Maria D; Georgakilas, Georgios; Kostoulas, Nikos; Vlachos, Ioannis S; Vergoulis, Thanasis; Reczko, Martin; Filippidis, Christos; Dalamagas, Theodore; Hatzigeorgiou, A G

    2013-07-01

    MicroRNAs (miRNAs) are small endogenous RNA molecules that regulate gene expression through mRNA degradation and/or translation repression, affecting many biological processes. DIANA-microT web server (http://www.microrna.gr/webServer) is dedicated to miRNA target prediction/functional analysis, and it is being widely used from the scientific community, since its initial launch in 2009. DIANA-microT v5.0, the new version of the microT server, has been significantly enhanced with an improved target prediction algorithm, DIANA-microT-CDS. It has been updated to incorporate miRBase version 18 and Ensembl version 69. The in silico-predicted miRNA-gene interactions in Homo sapiens, Mus musculus, Drosophila melanogaster and Caenorhabditis elegans exceed 11 million in total. The web server was completely redesigned, to host a series of sophisticated workflows, which can be used directly from the on-line web interface, enabling users without the necessary bioinformatics infrastructure to perform advanced multi-step functional miRNA analyses. For instance, one available pipeline performs miRNA target prediction using different thresholds and meta-analysis statistics, followed by pathway enrichment analysis. DIANA-microT web server v5.0 also supports a complete integration with the Taverna Workflow Management System (WMS), using the in-house developed DIANA-Taverna Plug-in. This plug-in provides ready-to-use modules for miRNA target prediction and functional analysis, which can be used to form advanced high-throughput analysis pipelines.

  9. How well do preschoolers identify healthy foods? Development and preliminary validation of the Dietary Interview Assessing Nutritional Awareness (DIANA).

    Science.gov (United States)

    Graziano, Paulo A

    2015-09-01

    The current study aimed to develop and initially validate a brief Dietary Interview Assessing Nutritional Awareness (DIANA) that mapped onto the Stop-Light Diet System. Participants for this study included 69 preschool children (83% boys; mean age = 5.13 years; 86% Latino) recruited from two summer programs. Children were presented with 24 pictures and were asked to name the food and indicate how healthy they felt each food was by pointing to a smiley face (very healthy = Green/Go food), neutral face (somewhat healthy = Yellow/Slow food), or a sad face (not healthy at all = Red/Whoa foods). Psychometric properties of the DIANA were assessed via a baseline assessment while children were re-administered the DIANA within 4-6 weeks to ascertain the test-retest reliability. Discriminant validity was also assessed in an exploratory fashion with a small subsample (n = 11) of children who participated in a healthy-lifestyle intervention program (HIP). Results indicated that the internal consistency of the DIANA for both the expressive knowledge and the health classification scales was acceptable (α = .83 and .82, respectively) along with the test-retest reliability (ICC = .86 and .81, respectively). Lastly, children who participated in HIP experienced greater gains in their ability to classify food based on the Stop-Light System and greater expressive knowledge of Green/Go foods compared to children who did not participate in the intervention suggesting adequate construct validity. These findings highlight the feasibility and utility of the DIANA in assessing young children's knowledge of foods and their relative healthiness as well as its potential sensitivity to intervention effects. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. DIANA Code: Design and implementation of an analytic core calculus code by two group, two zone diffusion

    International Nuclear Information System (INIS)

    Mochi, Ignacio

    2005-01-01

    The principal parameters of nuclear reactors are determined in the conceptual design stage.For that purpose, it is necessary to have flexible calculation tools that represent the principal dependencies of such parameters.This capability is of critical importance in the design of innovative nuclear reactors.In order to have a proper tool that could assist the conceptual design of innovative nuclear reactors, we developed and implemented a neutronic core calculus code: DIANA (Diffusion Integral Analytic Neutron Analysis).To calculate the required parameters, this code generates its own cross sections using an analytic two group, two zones diffusion scheme based only on a minimal set of data (i.e. 2200 m/s and fission averaged microscopic cross sections, Wescott factors and Effective Resonance Integrals).Both to calculate cross sections and core parameters, DIANA takes into account heterogeneity effects that are included when it evaluates each zone.Among them lays the disadvantage factor of each energy group.DIANA was totally implemented through Object Oriented Programming using C++ language. This eases source code understanding and would allow a quick expansion of its capabilities if needed.The final product is a versatile and easy-to-use code that allows core calculations with a minimal amount of data.It also contains the required tools needed to perform many variational calculations such as the parameterisation of effective multiplication factors for different radii of the core.The diffusion scheme s simplicity allows an easy following of the involved phenomena, making DIANA the most suitable tool to design reactors whose physics lays beyond the parameters of present reactors.All this reasons make DIANA a good candidate for future innovative reactor analysis

  11. Clinton, Diana, ¿dónde se metieron los periódicos serios?

    Directory of Open Access Journals (Sweden)

    Lic. Francisco Javier Acuña Arias

    1999-01-01

    Full Text Available Uno dividió toda la vida los periódicos en dos clases: los amarillistas y los demás. Los demás eran los "serios", es decir, los que uno leía. Pero a raíz del reciente escándalo de Bill Clinton y la cobertura de la muerte aparatosa de Diana de Gales, cabe preguntarse dónde se metieron los periódicos serios. Revistas tan circunspectas como Time y diarios tan reposados como The New York Times se lanzaron a ver quién era más estrepitoso. Total, lo de Clinton no pasó de ser un chisme de pasillo agrandado a crisis de estado por circunstancias picantes.

  12. Stasi partisanide saaga / Aimar Ventsel

    Index Scriptorium Estoniae

    Ventsel, Aimar, 1970-

    2004-01-01

    Berliini ajalehes Die Tageszeitung avaldatud artiklist, kuidas Saksamaa Kommunistliku Partei võitlusrühmad harjutasid enne Berliini müüri langemist 1989. aastal Ida-Saksamaal partisanivõitlust ja kuidas toodi Lääne-Saksamaalt noori radikaalseid kommuniste, keda õpetati saladuskatte all vastupanuvõitlejateks

  13. Crawford, Elisabeth: "Arrhenius: From Ionic Theory to the Greenhouse Effect" (Canton 1996); and Diana Barkan: "Walther Nernst and the Transition to Modern Physical Science" (Cambridge 1999) (book review)

    OpenAIRE

    Peter J. Ramberg

    2000-01-01

    book review of Crawford, Elisabeth: "Arrhenius: From Ionic Theory to the Greenhouse Effect" (Canton 1996); and Diana Barkan: "Walther Nernst and the Transition to Modern Physical Science" (Cambridge 1999)

  14. Búsqueda de nuevas dianas terapéuticas en psoriasis. Papel de la terapia biológica

    OpenAIRE

    Morón Romero, Rocío

    2018-01-01

    El trabajo búsqueda de nuevas dianas terapéuticas en psoriasis. Papel de la terapia biológica se centra dentro del programa biología del desarrollo, cáncer, biología molecular y farmacología. Estudiaremos las dianas terapéuticas implicadas en esta patología para decidir el tratamiento más específico a cada paciente. El descubrimiento de este tipo de terapias ha supuesto grandes avances en investigación, todavía queda mucho camino para su utilización en la práctica clínica habitual. El treb...

  15. In Conexione: a imaginação do sagrado na ciberarte de Diana Domingues

    Directory of Open Access Journals (Sweden)

    Leila Amaral

    2008-06-01

    Full Text Available Tendo como referência os trabalhos da artista plástica Diana Domingues será apresentada uma reflexão sobre a imaginação do sagrado nas artes visuais a partir da interpretação de temas, imagens, materiais e categorias formais que sustentam a linguagem contemporânea quando se trata do corpo em sua relação com as novas tecnologias comunicacionais. O foco da interpretação oferecida recairá sobre o sentido de sagrado (ou daquilo que é espiritual na "arte interativa" dessa artista. Tal sentido refere-se a um estado de comunicação e conectividade ampliada responsável pela expansão da consciência humana, a partir da experimentação pelo corpo da desestabilização de mundos fixos e acabados propiciada pelas novas tecnologias. O que é espiritual e sagrado para essa vertente artística é a "não essencialidade" da vida e do ser humano ou vida como "pura conectividade". É justo isso que se torna aparente através de suas "obras-dispositivos". Por meio delas, a artista explora ritual, performática e esteticamente a capacidade interativa das novas tecnologias na criação de ambientes vivos e na visualização da vida não como ela é, mas como ela pode ser. O que é sagrado é esse poder recebido das tecnologias que, ao serem acionadas por meio da conectividade, fazem aparecer a própria potência humana de intervir no mundo real e de alterar o ambiente. Não é a tecnologia em si mesma que é sagrada, mas a expansão do universo paralela à expansão da consciência por ela possibilitada, através da ampliação das conexões entre sistemas diferentes. O que é espiritual é, então, esse estado constante de transformação da consciência e da criatividade humana para além da subjetividade individual, porque, segundo essa vertente artística, os poderes recebidos pelas novas tecnologias são eles mesmos da ordem do "ultra-humano", de um "sujeito impessoal ultra-subjetivo".Based on the work of the Brazilian plastic artist Diana

  16. THE THIRD MARGIN OF HISTORY. NOTES ON THE TWO FACES OF WAR BY DIANA ANDRINGA AND FLORA GOMES

    Directory of Open Access Journals (Sweden)

    Livia Apa

    2010-11-01

    Full Text Available The essay intends to approach, taking the documentary authored by the Portuguese journalist Diana Andringa and the Guinea producer Flora Gomes as a starting point, the theme of the memories in conflict, and to reflect upon the manners in which the image archives may function in the process of construction of a collective and shared memory. In this sense, the Portuguese documentary in question seems to present a route that passes by the issue of the “war of memories” proposing a common reading of the histories which occurred on the Guinean front during the colonial war; proposing a reading of the facts which stress how, in accordance to what Amílcar Cabral affirmed, the fate of the two sides, in this particular case, Portugal and Guinea- Bissau, were indissolubly connected.

  17. Transnacionalismo e Gnose Liminar em “As Brasíadas” (2013, de Diana Menasché

    Directory of Open Access Journals (Sweden)

    Leoné Astride Barzotto

    2016-10-01

    Full Text Available Este artigo faz uma análise pós-colonial do poema “As Brasíadas”, de Diana Menasché. Este poema é parte da obra Traz o esqueleto que eu ponho a carne (2013 e, por meio dele, a autora faz uma releitura, à luz da contemporaneidade, da canônica obra de Luís de Camões, Os Lusíadas. Apesar de manter a forma do épico de Camões, Menasché atualiza o discurso e revela aspectos de transnacionalismo e de gnose liminar em sua escrita. Assim, eu proponho expor que, enquanto escritora brasileira imigrante nos Estados Unidos, ela constrói uma literatura híbrida e transfronteiriça, marcada pelo trânsito de saberes interamericanos e pela proposta de uma gnose (epistemologia liminar que revela o vínculo entre nações e práticas culturais emancipatórias.

  18. De pictura poesis: Giulio Roscio, il Triumphus Martyrum, gli Emblemata Sacra (ed il Tasso, la Diana e Callisto / De pictura poesis: Giulio Roscio, the Triumphus Martyrum, the Emblemata Sacra (and Tasso, the Diana and Callisto

    Directory of Open Access Journals (Sweden)

    Mauro Sarnelli

    2017-12-01

    Full Text Available Nella vasta produzione letteraria di Giulio Roscio (Orte ca. 1550 – Milano 1591, tutta umanistica, un significato per diversi aspetti particolare e privilegiato riveste il versante dedicato alle opere d’arte, sia nella celebrazione delle imprese archeologiche ed architettoniche del pontificato di Sisto v Peretti, sia nell’illustrazione poetica di realizzazioni pittoriche. È questo il caso relativo al ciclo dei trentun affreschi martirologici dipinti, nella chiesa romana di Santo Stefano Rotondo al Celio, ad opera di Nicolò Circignani (il Pomarancio seniore e di Matteo da Siena nel 1582, le incisioni dei quali, realizzate da Giovanni Battista de’ Cavalieri, sono all’origine dei corrispondenti epigrammi latini che costituiscono il Triumphus Martyrum in templo D. Stephani Caelii montis expressus rosciano (Roma 1587 e 1589, a cui è da connettere l’edizione dei gesuitici Emblemata sacra S. Stephani Caelii montis intercolumniis affixa procurata dal letterato (Roma 1589, l’uno e gli altri da inserire nella contestualizzazione storico-culturale dell’ultimo dialogo tassiano, Il Conte overo de l’imprese (ed. pr. Napoli 1594. Di grande importanza è poi un epigramma testimoniato solo da due esemplari dell’incisione a bulino, attribuita all’artista olandese Cornelis Cort, riproducente una delle due «poesie» mitologiche commissionate da Filippo ii di Spagna al Tiziano, ovvero la Diana e Callisto. La finalità del presente lavoro è d’indagare il senso storico-letterario e la portata storico-culturale dell’operazione poetica condotta dal Roscio.   In Giulio Roscio’s (Orte ar. 1550 – Milano 1591 wide and all humanistic literary production, a particular relevance and meaning assumes the part dedicated to artworks, both in celebrating Sixtus V Peretti’s archaeological and architectural enterprises, and in illustrating poetically pictorial creations. This is the case of the thirty-one martyrological frescoes painted in 1582

  19. Three book about Evenki / Aimar Ventsel

    Index Scriptorium Estoniae

    Ventsel, Aimar, 1970-

    2014-01-01

    Arvustus: Сирина, Анна. Эвенки и эвены с современном мире. Самосознание, природопользование, мировозрение. Moskva: Vostochnaia literature, 2012; Поворознюк, Ольга. Забайкальские эвенки. Социально-экономические и культурные трансформации в XX-XXI. Moskva: IEA RAN, 2011; Safonova, Tatiana, Santha Istvan. Culture contact in Evenki Land. A cybernetic anthropology of the Baikal region. Leiden & Boston: Global Oriental, 2013

  20. Afganistani muusikast ja mitte automaadist / Aimar Ventsel

    Index Scriptorium Estoniae

    Ventsel, Aimar, 1970-

    2010-01-01

    Afganistani muusikast. Taliban on keelanud maal ära muusika ja muusikariistad. Afganistani muusikat salvestatakse sageli riigist väljaspool. Samuti on äärmiselt haruldased naismuusikud. Rahvapillist rubabist

  1. DianaHealth.com, an On-Line Database Containing Appraisals of the Clinical Value and Appropriateness of Healthcare Interventions: Database Development and Retrospective Analysis.

    Science.gov (United States)

    Bonfill, Xavier; Osorio, Dimelza; Solà, Ivan; Pijoan, Jose Ignacio; Balasso, Valentina; Quintana, Maria Jesús; Puig, Teresa; Bolibar, Ignasi; Urrútia, Gerard; Zamora, Javier; Emparanza, José Ignacio; Gómez de la Cámara, Agustín; Ferreira-González, Ignacio

    2016-01-01

    To describe the development of a novel on-line database aimed to serve as a source of information concerning healthcare interventions appraised for their clinical value and appropriateness by several initiatives worldwide, and to present a retrospective analysis of the appraisals already included in the database. Database development and a retrospective analysis. The database DianaHealth.com is already on-line and it is regularly updated, independent, open access and available in English and Spanish. Initiatives are identified in medical news, in article references, and by contacting experts in the field. We include appraisals in the form of clinical recommendations, expert analyses, conclusions from systematic reviews, and original research that label any health care intervention as low-value or inappropriate. We obtain the information necessary to classify the appraisals according to type of intervention, specialties involved, publication year, authoring initiative, and key words. The database is accessible through a search engine which retrieves a list of appraisals and a link to the website where they were published. DianaHealth.com also provides a brief description of the initiatives and a section where users can report new appraisals or suggest new initiatives. From January 2014 to July 2015, the on-line database included 2940 appraisals from 22 initiatives: eleven campaigns gathering clinical recommendations from scientific societies, five sets of conclusions from literature review, three sets of recommendations from guidelines, two collections of articles on low clinical value in medical journals, and an initiative of our own. We have developed an open access on-line database of appraisals about healthcare interventions considered of low clinical value or inappropriate. DianaHealth.com could help physicians and other stakeholders make better decisions concerning patient care and healthcare systems sustainability. Future efforts should be focused on

  2. DianaHealth.com, an On-Line Database Containing Appraisals of the Clinical Value and Appropriateness of Healthcare Interventions: Database Development and Retrospective Analysis.

    Directory of Open Access Journals (Sweden)

    Xavier Bonfill

    Full Text Available To describe the development of a novel on-line database aimed to serve as a source of information concerning healthcare interventions appraised for their clinical value and appropriateness by several initiatives worldwide, and to present a retrospective analysis of the appraisals already included in the database.Database development and a retrospective analysis. The database DianaHealth.com is already on-line and it is regularly updated, independent, open access and available in English and Spanish. Initiatives are identified in medical news, in article references, and by contacting experts in the field. We include appraisals in the form of clinical recommendations, expert analyses, conclusions from systematic reviews, and original research that label any health care intervention as low-value or inappropriate. We obtain the information necessary to classify the appraisals according to type of intervention, specialties involved, publication year, authoring initiative, and key words. The database is accessible through a search engine which retrieves a list of appraisals and a link to the website where they were published. DianaHealth.com also provides a brief description of the initiatives and a section where users can report new appraisals or suggest new initiatives. From January 2014 to July 2015, the on-line database included 2940 appraisals from 22 initiatives: eleven campaigns gathering clinical recommendations from scientific societies, five sets of conclusions from literature review, three sets of recommendations from guidelines, two collections of articles on low clinical value in medical journals, and an initiative of our own.We have developed an open access on-line database of appraisals about healthcare interventions considered of low clinical value or inappropriate. DianaHealth.com could help physicians and other stakeholders make better decisions concerning patient care and healthcare systems sustainability. Future efforts should be

  3. Búsqueda de dianas terapeúticas en la célula Beta-Pancreática para el tratamiento de la diabetes

    OpenAIRE

    López Acosta, José Francisco

    2013-01-01

    Hay una urgencia de encontrar nuevas dianas terapéuticas y fármacos eficaces para el tratamiento de la diabetes mellitus, para mejorar el control glucémico y las complicaciones de la diabetes. La viabilidad y función de las células beta-pancreáticas se vean afectadas en las dos formas más comunes de diabetes, tipo 1 y tipo 2. La regeneración de la masa de células beta-pancreáticas funcional ha sido propuesto como un tratamiento potencial para la diabetes. Por lo tanto, hemos propuesto dos obj...

  4. The Psychology of Music, editado por Diana Deutsch, 3ª edição: resenha dos capítulos 10 a 13

    OpenAIRE

    Ricieri Carlini Zorzal

    2016-01-01

    O presente texto traz uma resenha de quatro capítulos da terceira edição do livro The Psychology of Music, editado por Diana Deutsch. Nominalmente, são analisados os seguintes capítulos: 10) Performance musical: movimento e coordenação, de autoria de Caroline Palmer; 11) Desenvolvimento musical, de autoria de Laurel Trainor e Erin Hannon; 12) Música e habilidades cognitivas, de autoria de Glenn Schellenberg e Michael Weiss; e 13) As fundações biológicas da música: insights da amusia congênita...

  5. The Psychology of Music, editado por Diana Deutsch, 3ª edição: resenha dos quatro capítulos finais

    OpenAIRE

    Ricieri Carlini Zorzal

    2015-01-01

    O presente texto traz uma resenha dos quatro capítulos finais da terceira edição do livro The Psychology of Music, editado por Diana Deutsch. Dessa forma, são analisados, individualmente, os seguintes capítulos: 14) Plasticidade cerebral induzida pelo treinamento musical, de autoria de Catherine Wan e Gottfried Schlaug; 15) Música e emoção, de autoria de Patrik Juslin e John Sloboda; 16) Cognição musical comparativa: estudos entre espécies e entre culturas, de autoria de Aniruddh Patel e Stev...

  6. Papel de la Vitamina D en la postmenopausia. Influencia de la suplementación en el metabolismo óseo y otras dianas.

    OpenAIRE

    Arribas Ferriol, Gemma

    2015-01-01

    Actualmente existe un problema de salud mundial con la osteoporosis postmenopáusica y entre los determinantes de salud ósea está un nivel adecuado de vitamina D. También cabe considerar que mantener un nivel adecuado de dicha vitamina influye en otras dianas determinantes en la salud en la postmenopausia, como es el nivel de lípidos, glucemia e insulina, tensión arterial o peso. Entre las tácticas recomendadas por las guías de práctica clínica se contempla la suplementación universal con v...

  7. The Psychology of Music, editado por Diana Deutsch, 3ª edição: resenha dos capítulos 10 a 13

    Directory of Open Access Journals (Sweden)

    Ricieri Carlini Zorzal

    2016-03-01

    Full Text Available O presente texto traz uma resenha de quatro capítulos da terceira edição do livro The Psychology of Music, editado por Diana Deutsch. Nominalmente, são analisados os seguintes capítulos: 10 Performance musical: movimento e coordenação, de autoria de Caroline Palmer; 11 Desenvolvimento musical, de autoria de Laurel Trainor e Erin Hannon; 12 Música e habilidades cognitivas, de autoria de Glenn Schellenberg e Michael Weiss; e 13 As fundações biológicas da música: insights da amusia congênita, de autoria de Isabelle Peretz.

  8. Geologic framework and hydrogeologic characteristics in the southern part of the Rancho Diana Natural Area, northern Bexar County, Texas, 2008-10

    Science.gov (United States)

    Clark, Allan K.; Morris, Robert R.

    2011-01-01

    The area designated by the city of San Antonio as the Rancho Diana Natural Area is in northern Bexar County, near San Antonio, Texas. During 2008-10, the U.S. Geological Survey, in cooperation with the city of San Antonio, documented the geologic framework and mapped the hydrogeologic characteristics for the southern part of the Rancho Diana Natural Area. The geologic framework of the study area and its hydrogeologic characteristics were documented using field observations and information from previously published reports. Many of the geologic and hydrogeologic features were found by making field observations through the dense vegetation along gridlines spaced approximately 25 feet apart and documenting the features as they were located. Surface geologic features were identified and hydrogeologic features such as caves, sinkholes, and areas of solutionally enlarged porosity were located using hand-held Global Positioning System units. The location data were used to create a map of the hydrogeologic subdivisions and the location of karst features. The outcrops of the Edwards and Trinity aquifer recharge zones were mapped by using hydrogeologic subdivisions modified from previous reports. All rocks exposed within the study area are of sedimentary origin and Lower Cretaceous in age. The valley floor is formed in the cavernous member of the upper Glen Rose Limestone of the Trinity Group. The hills are composed of the basal nodular member, dolomitic member, Kirschberg evaporite member, and grainstone member of the Kainer Formation of the Edwards Group. Field observations made during this study of the exposed formations and members indicate that the formations and members typically are composed of mudstones, wackestones, packstones, grainstones, and argillaceous limestones, along with marls. The upper Glen Rose Limestone is approximately 410 to 450 feet thick but only the upper 70 feet is exposed in the study area. The Kainer Formation is approximately 255 feet thick in

  9. INFECTADA POR LA EMOCIÓN: LA MÚSICA DE JANE BADLER Y LA MADURACIÓN DE DIANA EN LA SERIE V (1983-2011

    Directory of Open Access Journals (Sweden)

    Gerardo Rodríguez Salas

    2014-10-01

    Full Text Available Es una verdad universalmente conocida que una sola disciplina es insuficiente para cubrir el alcance de la cultura como un todo (Johnson, 1986: 279. Como padre fundador de los estudios culturales, Raymond Williams definía este campo como “a vague and baggy monster” (1989: 158 que demanda una aproximación interdisciplinaria. Consciente del prejuicio que el estudio de las series televisivas de ciencia ficción despierta en el mundo académico, el presente estudio se adentra en el reto de analizar, desde una perspectiva de Estudios Culturales, la popular serie V, que combina elementos de ciencia ficción y de telenovela para hacerse con el interés del espectador. Se explorará este tándem teniendo en cuenta su limitación patriarcal de la agencia femenina tras una apariencia de empoderamiento de sus mujeres. En oposición a estos discursos, una de las protagonistas de la serie, Jane Badler (Diana, finalmente alcanza un efecto paródico a través del discurso alternativo de la música, donde transciende el cliché de heroínas/villanas en la ciencia ficción audiovisual—e.g. Ripley en la saga Alien, Helena Cain en Battlestar Galactica: Reimagined o Elizabeth Shaw y Meredith Vickers en la reciente Prometheus. Aunque mayoritariamente compuesta por varones, la música paródica de Badler, así como sus actuaciones y autoconsciencia satírica, ofrecen un espacio alternativo a la ciencia ficción, que sistemáticamente cierra la puerta al empoderamiento femenino.

  10. Diana Elvira Soto Arango. La escuela rural en Colombia. Historias de vida de maestras. Mediados del siglo xx. Tunja: fudesa, 2014. 216 páginas.

    Directory of Open Access Journals (Sweden)

    Doris Lilia Torres

    2015-01-01

    Full Text Available Me honra presentar este libro por dos razones: la primera es personal. Porque he tenido el asunto de la identidad del mestizo como una de mis preocupaciones, a través de la cual he tratado de encontrar las voces que hablan sobre lo que somos y cómo somos. Aunque Gabriel García Márquez universalizó nuestra cultura latinoamericana, no me deja de sorprender que cuando los escritores y periodistas de la Costa Atlántica se refieren a su vida y obra, lo hacen de una manera tan personal y cercana, que se siente cómo experimentan ese realismo mágico correr por su venas. De igual manera, leer el libro La Escuela rural en Colombia. Historias de vida de maestra. Mediados del siglo xx, de la Dra. Diana Elvira Soto, hizo que las emociones surgieran y brotaran con las imágenes, símbolos, descripciones y narraciones de las educadoras que vivieron en este altiplano cundiboyacense. Pude sentir el olor de la vereda, el sonido de la quebrada, la soledad de la escuela, lo mitos de la llorona y la patasola escondidos en los rincones de los salones de clase para apaciguar los ánimos, el frío del páramo del Vijagual en Rondón y la frescura del valle de los Ocobos en Miraflores. También sentí la zozobra y el miedo por la violencia y el desplazamiento de Yacopí a Bogotá. Allí la maestra, la mujer, la líder y madre va caminando por las veredas y municipios de una tierra abandonada y asediada por la corrupción política centralista, buscando un ideal y construyendo comunidades que avanzan con la elaboración mental que da el aprendizaje de la lectura y escritura, en manos de maestras como Amparo y Andrea, que creyeron en la construcción de comunidades más justas y menos discriminadas a través de la enseñanza de las letras y el lenguaje.

  11. Otvetshajet Diana Ingerainen, vitse-mer Tallinna / Diana Ingerainen

    Index Scriptorium Estoniae

    Ingerainen, Diana, 1971-

    2005-01-01

    Tallinna abilinnapea vastab küsimustele, kuidas perearstikeskused kasutavad endiste polikliinikute ruume ja meditsiiniaparatuuri, kui tihti võtavad perearste abistavad meditsiiniõed vastu patsiente iseseisvalt, millised on perearstide probleemid

  12. Model of an innovative and flexible IT company / Aimar Meltsa

    Index Scriptorium Estoniae

    Meltsa, Aimar

    2003-01-01

    Kaanel ajak. ilmumisaeg 2002/2003. Organisatsiooni strateegilise arengu eelduseks on muutusi toetava keskkonna ja organisatsioonikultuuri loomine. Innovaatilise infotehnoloogiaettevõtte mudeli rakendamine. Diagrammid. Skeem

  13. High Frequency Data Acquisition System for Modelling the Impact of Visitors on the Thermo-Hygrometric Conditions of Archaeological Sites: A Casa di Diana (Ostia Antica, Italy Case Study

    Directory of Open Access Journals (Sweden)

    Paloma Merello

    2018-01-01

    Full Text Available The characterization of the microclimatic conditions is fundamental for the preventive conservation of archaeological sites. In this context, the identification of the factors that influence the thermo-hygrometric equilibrium is key to determine the causes of cultural heritage deterioration. In this work, a characterization of the thermo-hygrometric conditions of Casa di Diana (Ostia Antica, Italy is carried out analyzing the data of temperature and relative humidity recorded by a system of sensors with high monitoring frequency. Sensors are installed in parallel, calibrated and synchronized with a microcontroller. A data set of 793,620 data, arranged in a matrix with 66,135 rows and 12 columns, was used. Furthermore, the influence of human impact (visitors is evaluated through a multiple linear regression model and a logistic regression model. The visitors do not affect the environmental humidity as it is very high and constant all the year. The results show a significant influence of the visitors in the upset of the thermal balance. When a tourist guide takes place, the probability that the hourly temperature variation reaches values higher than its monthly average is 10.64 times higher than it remains equal or less to its monthly average. The analysis of the regression residuals shows the influence of outdoor climatic variables in the thermal balance, such as solar radiation or ventilation.

  14. For a rereading of Latin American art historiography, from Diana Weschler’s concept of “Road Map” and María Soledad García’s “Compositions and decompositions”

    Directory of Open Access Journals (Sweden)

    Paola Camargo

    2010-11-01

    Full Text Available This essay analyses two proposals for new readings of the historiography of Latin American art made by two Argentine researchers, to begin to establish what questions are asked today by art historians, where are they directing their efforts to, and if there are meeting points between them. The first proposal is that of Diana Weschler (2008. Her work raises the following questions: Is it valid to think about modern Latin American art outside the perspective of reflexive modernities (see Beck, 1986, 1996; Beck, Giddens, y Lash, 1994? What are the implications for Latin American historiography of thinking about Modernity as a co-production? What events the concept ";Road Map"; enables us to think about?   The second one is that of María Soledad García (2009, who wonders what elements would shape a critical history of art: which historiographical principles would include the work of a critical history? How it might develop? Both works (Weschler, 2008 and García, 2009 give us a first approach to what is being discussed today in the field of Latin American art historiography, a discipline that has a tradition of six decades in Argentina, whereas in Colombia has just begun.

  15. Gómez Correal, Diana Marcela. 2012. Dinámicas del movimiento feminista bogotano. Historias de cuarto, salón y calle. Historias de vida (1970-1991. Bogotá: Universidad Nacional de Colombia ISBN: 9789587196535

    Directory of Open Access Journals (Sweden)

    Edwin Cruz Rodríguez

    2014-01-01

    Full Text Available En esta obra la antropóloga y magister en historia de la Universidad Nacional de Colombia, Diana Marcela Gómez Correal, reconstruye el feminismo de la segunda ola en Bogotá, entre 1970 y 1991. Es una narración estructurada en cinco capítulos, que destaca el papel de los sujetos en la construcción de la historia, mediante las historias de vida de diez de las protagonistas en estos años, y resalta el vínculo que su praxis establece entre lo que se considera privado y lo público-político. Sus testimonios van tejiendo la historia en primera persona, incluso la autora interviene como “sujeto ubicado” (p. 35 con una perspectiva feminista. Su preocupación por las dinámicas organizativas internas se explica por la intención de llenar un vacío en la historiografía del movimiento feminista, el cual es enmarcado dentro del más amplio movimiento social de mujeres. El análisis se nutre también de la categoría de género, puesta en el contexto de la “interseccionalidad” con los patrones de opresión de raza y clase.

  16. La ADN topoisomerasa tipo I de protozoos patógenos como Diana terapéutica de fármacos antitumorales Type I DNA topoisomerase from protozoan pathogens as a potential target for anti-tumoral drugs

    Directory of Open Access Journals (Sweden)

    Rosa M Reguera

    2007-12-01

    Full Text Available La utilización intensiva de fármacos antiparasitarios es la causa principal de la aparición de microorganismos parásitos multirresistentes en las regiones del planeta donde son precisamente endémicos. Los agentes etiológicos de las denominadas enfermedades tropicales -malaria, criptosporiodiosis, enfermedad del sueño, enfermedad de Chagas o los distintos tipos de leishmaniosis- son protozoos unicelulares sobre los que no se ha desarrollado en la actualidad ninguna vacuna eficaz y cuyo tratamiento se basa en medidas sanitarias preventivas y en el uso de medicamentos. La quimioterapia antiparasitaria actual es cara, no está ausente de efectos adversos y no supone beneficios a las empresas que la comercializan, por lo que la inversión en I & D es marginal comparada con la llevada a cabo para otros procesos patológicos de menor relevancia médica. La identificación de las ADN topoisomerasas como dianas farmacológicas se basa en los excelentes resultados obtenidos en los ensayos clínicos llevados a cabo con los derivados de la camptotecina en la terapia antitumoral. Las importantes diferencias estructurales entre las ADN topoisomerasas de tipo I de tripanosomas y leishmanias con respecto a sus homólogas de mamífero ha abierto un nuevo campo de investigación que combina las técnicas de biología molecular con la cristalización de proteínas para poder diseñar nuevos fármacos dirigidos específicamente a su inhibición. Revisamos aquí las características de estas nuevas dianas farmacológicas, así como los compuestos que en el momento están siendo utilizados para su inhibición en los agentes parasitarios que causan las principales enfermedades tropicales.The intensive use of antiparasitic drugs is the main cause of the emergence of multiresistant parasite strains on those regions where these parasites are endemic. The aetiological agents of the so-called tropical diseases viz. malaria, cryptosporidiosis, sleeping sickness

  17. Effect of UV radiation on the genetic inactivation of sperm of the bullseye puffer Sphoeroides annulatus (Jenyns, 1842); Efecto de la radiacion UV en la inactivacion genetica del esperma de botete diana Sphoeroides annulatus (Jenyns, 1842)

    Energy Technology Data Exchange (ETDEWEB)

    Arias-Rodriguez, Lenin; Rodriguez-Ibarra, Luz Estela; Del Valle-Pignataro, Gabriela [Laboratorio de Genetica, Centro de Investigacion en Alimentacion y Desarrollo, A. C., Sinaloa (Mexico)

    2004-09-15

    Genetic (DNA) inactivation of fish sperm with ultraviolet irradiation is generally accompanied by a paradoxical effect on survival rates (Hertwig effect). In the present study, sperm samples from ten males bullseye puffer fish (Sphoeroides annulatus) were diluted 1:50 using Cortland's extender solution and used to test the effect of nine ultraviolet doses (0.2-1.0 J cm{sup -}2 ) on motility time in seconds, motility index, and embryo survival rate after fertilizing eggs from five bullseye puffer females. Motility time of sperm irradiated with 0.2-0.9 J cm{sup -}2 were not statistically different from the controls, but sperm irradiated with a dosage of 1.0 J cm{sup -}2 dosage had significant lower motility time. Motility indices (MI) allowed for the statistical differentiation of four groups in relation to their response to different radiation doses: the first had high MI, and included the controls and 0.2-0.3 J cm{sup -}2 treatments; the second had lower MI and included the 0.4-0.7 J cm{sup -}2 treatments; the third showed recovery of MI and included the 0.8-0.9 J cm{sup -}2 treatments; and the fourth showed the lowest MI with the 1.0 J cm{sup -}2 treatment. Embryo survival was highest for the controls and 0.2 J cm{sup -}2 treatment, decreasing in the 0.3-0.4 J cm{sup -}2 treatments, increasing again in the 0.5-0.8 J cm{sup -}2 treatments, until reaching lowest survival in the 0.9-1.0 J cm{sup -}2 treatments. These results indicate that the best ultraviolet dosage to achieve genetic inactivation of sperm of this species is close to 0.7 J cm{sup -}2, a dosage in which fish fry showed typical haploid syndrome characteristics. [Spanish] La inactivacion genetica (ADN) del esperma de peces se realiza mediante luz ultravioleta que, en irradiaciones crecientes, genera efectos paradojicos (efecto Hertwig) en los porcentajes de supervivencia. En este trabajo se diluyeron muestras de semen provenientes de diez machos de botete diana (Sphoeroides annulatus) en solucion

  18. Siberist Tšetšeeniani Saksa-Vene koostöö nimel / Aimar Ventsel

    Index Scriptorium Estoniae

    Ventsel, Aimar, 1970-

    2005-01-01

    Aprilli keskel käisid Venemaa president Vladimir Putin ja Tšetšeenia asepresident Ramzan Kadõrov visiidil Saksamaal ning külastasid Saksamaa liidukantsleri Gerhard Schröderiga Hannoveri tehnoloogiamessi. Lisa: Kes on Ramzan Kadõrov?

  19. Análisis del proceso de urgencias y hospitalización del CAMI Diana Tubay a través de un modelo de simulación con Arena 10.0 para la distribución óptima del recurso humano

    Directory of Open Access Journals (Sweden)

    Liliana Maria Pantoja Rojas

    2008-01-01

    Full Text Available Este documento presenta un modelo de simulación que describe el procedimiento actual de Atención del Área de Urgencias y Hospitalización del Centro de Atención Médica Inmediata (CAMI DIANA TURBAY, Entidad Prestadora de Salud de Primer Nivel de carácter oficial en la ciudad de Bogotá. En el proceso se elaboró una síntesis de estu-dio y registro global de las actividades en las condiciones actuales de atención en el área de Urgencias y Hospitali-zación, así como propuestas que permitieran mejorar las condiciones de atención a los pacientes y que ayudaran a optimizar los recursos con los que dispone la institución en el área mencionada. Lo anterior se obtuvo contrastando los tiempos de espera, personas en cola y utilización del personal, con la propuesta de estructuración del proce-dimiento del triage presentado por la oficina de Gestión Pública y Autocontrol del Hospital Rafael Uribe Uribe y cu-yo procedimiento se desea implementar en el marco del proyecto de remodelación y ampliación del CAMI. Tam-bién se ensayan diferentes escenarios para evaluar la factibilidad en la reducción de tiempos de espera y número de personas en cola, probando diferentes alternativas de horarios y disposición de recursos de apoyo, con lo cual se muestra una reducción sustancial en los tiempos de atención y de espera de los pacientes.

  20. Eestikeelse loomuliku kõnesünteesi poole / Diana Krull

    Index Scriptorium Estoniae

    Krull, Diana, 1930-2013

    2008-01-01

    Arvustus: Mihkla, Meelis. Kõne ajalise struktuuri modelleerimine eestikeelsele tekst-kõne sünteesile = Modelling the temporal stucture of speech for the Estonian text-to-speech synthesis. Tartu : Tartu Ülikooli Kirjastus, 2007

  1. Oluline sõna arengus on turism / Diana Plakso

    Index Scriptorium Estoniae

    Plakso, Diana, 1971-

    2004-01-01

    Ilmunud ka: Äripäev : Eesti Edukamad Ettevõtted : Maakondlikud edetabelid Top 100, 26. nov. 2004, lk. 18. Põlvamaa ettevõtluse võimalikest arengusuundadest. Diagramm ja tabel: Tööstustoodang maakondades 2002. aastal; Ekspordi ülekaal kipub vähenema

  2. Elizabeth II üle Diana ja Tony / Kristiina Davidjants

    Index Scriptorium Estoniae

    Davidjants, Kristiina, 1974-

    2007-01-01

    Stephen Frearsi mängufilm "Kuninganna" ("The Queen") : stsenarist Peter Morgan : kuninganna Elizabeth II kehastab Helen Mirren peaminister Tony Blair'i Michael Sheen: Suurbritannia - Ameerika Ühendriigid - Itaalia 2006

  3. Modno vsjo! Nuzhno lish võbrat svojo / Diana Denissova

    Index Scriptorium Estoniae

    Denissova, Diana

    2006-01-01

    Moskva moenädalast. Näidati 50 pret-a-porter kollektsiooni sügis-talveks 2006/07. Valentin Judashkini, Natasha Driganti, Sergei Jefremovi, Vjatsheslav Zaitsevi, Ivan Aiplatovi ja Alena Ahmadulina kollektsioonidest

  4. A babotshka krõlõshkami... / Diana King

    Index Scriptorium Estoniae

    King, Diana

    2008-01-01

    Oksana Tanditi kollektsiooni Butterflies esitlus Tallinna galeriis Vaal. Kollektsioonis on kunstnik Ruth Tulvingu pildiseeriast "Liblikad" inspireeritud naisterõivad kevad-suveks 2009. 17 värvifotot

  5. Growth potential and growth factor of the IT company operating in Estonia : summary of the study conducted between August-October 2001 / Aimar Meltsa

    Index Scriptorium Estoniae

    Meltsa, Aimar

    2001-01-01

    Kaanel ajak. ilmumisaeg Winter 2001/2002. 2001.a. läbiviidud uuringus vaadeldi Eestis infotehnoloogia vallas tegutsevaid ettevõtteid, eesmärgiga hinnata nende potentsiaalset majanduskasvu ning neid tingimusi, mis seda määravad

  6. Growth potential and growth factor of the IT company operating in Estonia : summary of the study conducted between August-October 2001 / Aimar Meltsa

    Index Scriptorium Estoniae

    Meltsa, Aimar

    2002-01-01

    Kaanel ajak. ilmumisaeg 2001/2002. 2001.a. läbiviidud uuringus vaadeldi Eestis infotehnoloogia vallas tegutsevaid ettevõtteid, eesmärgiga hinnata nende potentsiaalset majanduskasvu ning neid tingimusi, mis seda määravad

  7. [Delphi consensus on management of dyslipidaemia in patients with impaired glucose metabolism: Diana study].

    Science.gov (United States)

    Pedro-Botet, Juan; Barrios, Vivencio; Pascual, Vicente; Ascaso, Juan F; Cases, Aleix; Millán, Jesús; Serrano, Adalberto; Pintó, Xavier

    2016-01-01

    The aim of the present study was to develop a multidisciplinary consensus based on the Delphi system to establish clinical recommendations for the management of dyslipidaemia when hyperglycaemia is present, and the relevant factors that should be taken into consideration when prescribing and monitoring treatment with statins. The questionnaire developed by the scientific committee included four blocks of questions about dyslipidaemia in patients with impaired glucose metabolism. The results of the first two blocks are presented here: a) management of dyslipidaemia; b) relevant factors that should be taken into consideration when prescribing and monitoring treatment with statins. Among the 497 experts who participated in the study, an agreement of over 90% was attained for recommending screening for dyslipidaemia in patients with diabetes or pre-diabetes and/or cardiovascular disease or a family history and/or abdominal obesity and/or hypertension. There was a high degree of agreement that a statin is the lipid-lowering treatment of choice, and that it should be switched when side effects develop. Also, the choice of statin and dose should be made according to baseline LDL cholesterol levels, the target to achieve, and the possible drug-drug interactions. The screening of dyslipidaemia is primarily conducted in patients with cardiovascular disease, or any major cardiovascular risk factor. When prescribing a statin, physicians mainly focus on the ability to reduce LDL cholesterol and the risk of drug interactions. Copyright © 2016 Sociedad Española de Arteriosclerosis. Published by Elsevier España. All rights reserved.

  8. Socio-cultural impacts on drug trafficking trends in Europe / Diana S Dolliver

    Index Scriptorium Estoniae

    Dolliver, Diana S

    2015-01-01

    Empiirilisest uuringust, milles analüüsiti neljateistkümnest Euroopa riigist kogutud andmeid aaastatel 1995 kuni 2009. Uuringus keskenduti kanepi, heroiini, kokaiini ja amfetamiiniga kaubitsemisele

  9. "Biennale en scene" keskendus hääle erinevatele võimalustele / Diana Kiivit

    Index Scriptorium Estoniae

    Kiivit, Diana

    2006-01-01

    7. - 26. märtsil Lyonis toimunud festivalist "Biennale en scene" ja seal etendunud kolmest ooperist: G. Aperghis "Entre chien et loup", C. Ambrosini "Il canbto della pelle", P. Dusapini "Faustus, la derniere nuit"

  10. Valitsuse poliitika erinõuetega tegevusalade tegevuslubade väljastamisel / Diana Eerma

    Index Scriptorium Estoniae

    Eerma, Diana, 1964-

    2002-01-01

    Tegevusload- ja litsentsid riiklike turutõketena, tegevuslubade kehtestamise eesmärkide analüüs ja tasuvuse hindamise lähtekohad. Tegevuslubadega seotud probleemidest Eestis. Tabelid: turutõkete näiteid; tegevuslubade kehtestamise eesmärgid

  11. DNA-linked Inhibitor Antibody Assay (DIANA) for sensitive and selective enzyme detection and inhibitor screening

    Czech Academy of Sciences Publication Activity Database

    Navrátil, Václav; Schimer, Jiří; Tykvart, Jan; Knedlík, Tomáš; Vik, V.; Majer, Pavel; Konvalinka, Jan; Šácha, Pavel

    2017-01-01

    Roč. 45, č. 2 (2017), č. článku e10. ISSN 0305-1048 R&D Projects: GA MŠk LO1302 Institutional support: RVO:61388963 Keywords : quantitative PCR * enzyme detection * inhibitor screening Subject RIV: CE - Biochemistry OBOR OECD: Biochemical research methods Impact factor: 10.162, year: 2016 https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkw853

  12. U-Pb age of the Diana Complex and Adirondack granulite ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    tinental geothermal gradient (e.g. Ganguly et al. 1995). The Adirondack Mountains of New York have been an important area for the study of massif- type anorthosites and associated granulites for formulating and testing many of the ideas of petrologic, thermal-barometric, geochronological, isotopic, and geochemical ...

  13. U-Pb age of the Diana Complex and Adirondack granulite ...

    Indian Academy of Sciences (India)

    For the most concordant analyses, the 207Pb/206Pb ages range between 1115 and 1150 Ma. Detailed petrographic studies revealed that most grains contained at least two phases of zircon growth, either primary magmatic cores enclosed by variable thickness of metamorphic overgrowths or magmatic portions enclosing ...

  14. Competition creation and regulation in case of Estonian competition policy / Diana Eerma, Jüri Sepp

    Index Scriptorium Estoniae

    Eerma, Diana, 1964-

    2006-01-01

    Riikliku reguleerimise peaeesmärgiks on suurendada majanduslikku ja sotsiaalset heaolu ning luua makro- ja mikromajanduslik keskkond selleks, et kindlustada ettevõtete konkurentsivõime. Eesti konkurentsipoliitika näitel analüüsitakse konkurentsi loomist ja riiklikku reguleerimist turule sisenemisel

  15. Kudoa dianae sp. n. (Myxosporea: Multivalvulida) a new parasite of bullseye puffer, Sphoeroides annulatus (Tetraodontiformes: Tetraodontidae)

    Czech Academy of Sciences Publication Activity Database

    Dyková, Iva; Fajer, E. J.; Fiala, Ivan

    2002-01-01

    Roč. 49, č. 1 (2002), s. 17-23 ISSN 0015-5683 Grant - others: CONACyT (MX) 36621 Institutional research plan: CEZ:AV0Z6022909 Keywords : Myxosporea * Multivalvulida * taxonomy Subject RIV: EA - Cell Biology Impact factor: 0.515, year: 2002

  16. Psoriasis : inmunopatogenia y dianas terapéuticas de los tratamientos biológicos

    OpenAIRE

    Buendía de Guezala, Ainoa

    2017-01-01

    La enfermedad psoriásica o psoriasis es una enfermedad cutánea crónica, relativamente frecuente, que habitualmente afecta a otros órganos. En este trabajo se ha realizado una revisión bibliográfica de los datos epidemiológicos, sus múltiples factores etiológicos, los aspectos clínicos y anatomopatológicos, finalizando con la patogenia y el tratamiento de la misma. Se ha hecho especial hincapié en el papel que el sistema inmune juega en el desencadenamiento de la psoriasis, centrándonos en ...

  17. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Marie Beurton-Aimar. Articles written in Journal of Biosciences. Volume 32 Issue 1 January 2007 pp 145-155 Articles. Formal TCA cycle description based on elementary actions · Pierre Mazière Nicolas Parisey Marie Beurton-Aimar Franck Molina · More Details Abstract Fulltext PDF.

  18. DIANA: A Machine Learning Mechanism for Adjusting the TDD Uplink-Downlink Configuration in XG-PON-LTE Systems

    Directory of Open Access Journals (Sweden)

    Panagiotis Sarigiannidis

    2017-01-01

    Full Text Available Modern broadband hybrid optical-wireless access networks have gained the attention of academia and industry due to their strategic advantages (cost-efficiency, huge bandwidth, flexibility, and mobility. At the same time, the proliferation of Software Defined Networking (SDN enables the efficient reconfiguration of the underlying network components dynamically using SDN controllers. Hence, effective traffic-aware schemes are feasible in dynamically determining suitable configuration parameters for advancing the network performance. To this end, a novel machine learning mechanism is proposed for an SDN-enabled hybrid optical-wireless network. The proposed architecture consists of a 10-gigabit-capable passive optical network (XG-PON in the network backhaul and multiple Long Term Evolution (LTE radio access networks in the fronthaul. The proposed mechanism receives traffic-aware knowledge from the SDN controllers and applies an adjustment on the uplink-downlink configuration in the LTE radio communication. This traffic-aware mechanism is capable of determining the most suitable configuration based on the traffic dynamics in the whole hybrid network. The introduced scheme is evaluated in a realistic environment using real traffic traces such as Voice over IP (VoIP, real-time video, and streaming video. According to the obtained numerical results, the proposed mechanism offers significant improvements in the network performance in terms of latency and jitter.

  19. The clinical and integrated management of COPD. An official document of AIMAR (Interdisciplinary Association for Research in Lung Disease), AIPO (Italian Association of Hospital Pulmonologists), SIMER (Italian Society of Respiratory Medicine), SIMG (Italian Society of General Medicine).

    Science.gov (United States)

    Bettoncelli, Germano; Blasi, Francesco; Brusasco, Vito; Centanni, Stefano; Corrado, Antonio; De Benedetto, Fernando; De Michele, Fausto; Di Maria, Giuseppe U; Donner, Claudio F; Falcone, Franco; Mereu, Carlo; Nardini, Stefano; Pasqua, Franco; Polverino, Mario; Rossi, Andrea; Sanguinetti, Claudio M

    2014-01-01

    COPD is a chronic pathological condition of the respiratory system characterized by persistent and partially reversible airflow obstruction, to which variably contribute remodeling of bronchi (chronic bronchitis), bronchioles (small airway disease) and lung parenchyma (pulmonary emphysema). COPD can cause important systemic effects and be associated with complications and comorbidities. The diagnosis of COPD is based on the presence of respiratory symptoms and/or a history of exposure to risk factors, and the demonstration of airflow obstruction by spirometry. GARD of WHO has defined COPD "a preventable and treatable disease". The integration among general practitioner, chest physician as well as other specialists, whenever required, assures the best management of the COPD person, when specific targets to be achieved are well defined in a diagnostic and therapeutic route, previously designed and shared with appropriateness. The first-line pharmacologic treatment of COPD is represented by inhaled long-acting bronchodilators. In symptomatic patients, with pre-bronchodilator FEV1 pulmonary arterial hypertension, cor pulmonale, or edema of the lower limbs or hematocrit > 55%. Respiratory rehabilitation is addressed to patients with chronic respiratory disease in all stages of severity who report symptoms and limitation of their daily activity. It must be integrated in an individual patient tailored treatment as it improves dyspnea, exercise performance, and quality of life. Acute exacerbation of COPD is a sudden worsening of usual symptoms in a person with COPD, over and beyond normal daily variability that requires treatment modification. The pharmacologic therapy can be applied at home and includes the administration of drugs used during the stable phase by increasing the dose or modifying the route, and adding, whenever required, drugs as antibiotics or systemic corticosteroids. In case of patients who because of COPD severity and/or of exacerbations do not respond promptly to treatment at home hospital admission should be considered. Patients with "severe" or "very severe" COPD who experience exacerbations should be carried out in respiratory unit, based on the severity of acute respiratory failure. An integrated system is required in the community in order to ensure adequate treatments also outside acute care hospital settings and rehabilitation centers. This article is being simultaneously published in Sarcoidosis Vasc Diffuse Lung Dis 2014, 31(Suppl. 1);3-21.

  20. Estudio de la función biológica de la protimosina α mediantela caracterización de sus dianas moleculares

    OpenAIRE

    Barbeito González, Pablo

    2014-01-01

    La Protimosina α (ProTα) es una proteína ácida (pI 3,55) ampliamente distribuida en los tejidos de mamíferos, particularmente abundante en las células linfoides, y con una secuencia muy conservada. Presenta una señal de localización nuclear en el extremo C-terminal, y los primeros 28 aminoácidos del extremo N-terminal se corresponden con la Timosina α1 (Tα1), de la cual la ProTα es su precursor. La ProTα es fosforilada en residuos de treonina en células en proliferación por la isoforma M2 de ...

  1. Adenosina y control homeostático del sueño: Acciones en estructuras diana de los circuitos de vigilia y sueño

    OpenAIRE

    Carús-Cadavieco, Marta; Andrés, Isabel de

    2012-01-01

    La homeostasis del sueño se manifiesta ante situaciones de vigilia prolongada de forma natural o experimentalmente. En estos casos, se presenta somnolencia (o presión de sueño) y, cuando se permite dormir, hay un rebote del sueño en duración e intensidad que compensa la pérdida del mismo. Entre las moléculas que pueden intervenir en la regulación homeostática del sueño, se encuentra la adenosina, cuyos antagonistas, la cafeína y la teofilina, consume la población humana ampliament...

  2. Los receptores epidérmicos humanos en el cáncer gástrico: alteraciones moleculares y su papel como diana terapéutica.

    Science.gov (United States)

    Bustos-Carpinteyro, Andrea Rebeca; Magaña-Torres, María Teresa; González-García, Juan Ramón; Torres-Jasso, Juan Heriberto; Sánchez-López, Josefina Yoaly

    2017-01-01

    Gastric cancer (GC) is the third leading cause of cancer death worldwide; both environmental and genetic factors are involved in the etiology of this neoplasia. The human epidermal receptor (HER) pathway is essential for proliferation and differentiation of normal cells; but it is also implicated in the growth of cancer cells. In this work we investigate the molecular alterations in genes that encodes for HER receptors reported in GC, as well the role as therapeutic targets. We reviewed the literature reported to date regarding overexpression of HER-receptors, amplification and somatic mutations in ERBB genes occurred in gastric tumors, as well as the anti-HER therapies tested for treatment of GC. In GC, the overexpression of HER family is reported in a range of 12-87% of cases; up to 67% of cases with amplification, and 90 somatic mutations in ERBB genes. The only drug anti-HER approved for using combined with chemotherapy, in treatment of patients with advanced GC is trastuzumab; however, other targeted therapies are being investigated. The role of the HER family as a therapeutic target has not shown significant improvements in recent years; hence, further studies are required to find better options for treatment of GC. Copyright: © 2017 SecretarÍa de Salud.

  3. Konkurentsipoliitika infrastruktuursetes erandvaldkondades Eesti näitel: loomuliku monopoli ja universaalteenuste põimumine / Jüri Sepp, Diana Eerma

    Index Scriptorium Estoniae

    Sepp, Jüri, 1952-

    2011-01-01

    Artikli eesmärgiks on süstematiseerida ja hinnata erandvaldkondade reguleerimise majanduspoliitilisi meetmeid, kõrvutatakse eri valdkondade lahendusi omavahel ja normatiivse teooria seisukohtadega. Tabel

  4. Prurito en un paciente diabético, ¿indicador de lesión de órgano diana?

    Directory of Open Access Journals (Sweden)

    Sonsoles M Velilla-Zancada

    Full Text Available Se presenta el caso de un varón diabético e hipertenso de 71 años de edad, que tiene prurito generalizado, de probable etiología urémica, a consecuencia de un rápido deterioro de la función renal. Una vez modificado el tratamiento, con mejoría del filtrado glomerular y de los niveles de urea en sangre, la clínica desaparece y el paciente permanece asintomático.

  5. Muljeid täienduskoolituselt Kanada New Brunswicki Ülikoolis = Impressions of professional training in New Brunswick University, Canada / Diana Maisla

    Index Scriptorium Estoniae

    Maisla, Diana

    1999-01-01

    Õpingutest New Brunswicki Ülikoolis eesti keele kui teise keele õpetamise metoodika arendamise projekti "Estonian Language Training Project" raames. New Brunswicki Ülikool. Rööptekst inglise keeles

  6. Imatinib and gastrointestinal stromal tumor (GIST: a selective targeted therapy Imatinib y tumor del estroma gastrointestinal (GIST: un tratamiento selectivo frente a una diana molecular

    Directory of Open Access Journals (Sweden)

    A. Fernández

    2004-10-01

    Full Text Available Gastrointestinal stromal tumors are the most frequent mesenchymal tumors in the gastrointestinal tract. They originate from the interstitial cells of Cajal and are characterized by an anomalous receptor for a growth factor with tyrosine-kinase activity (c-kit. This anomaly causes a permanent activation of the receptor and uncontrolled cell growth. These tumors show a poor response to traditional chemotherapy drugs, and are thus associated with low survival in cases of advanced disease. Imatinib, a tyrosine kinase inhibitor, is an example of selective targeted oncologic therapy that induces improved survival in these patients. We discuss two cases of metastatic gastrointestinal stromal tumors with a good response to imatinib, and also review the pathophysiology and treatment-related outcome of this type of tumors. We include results from clinical phase-III studies.Los tumores del estroma gastrointestinal son los tumores mesenquimales más frecuentes del tracto digestivo y se originan de las células intersticiales de Cajal. Se caracterizan por presentar un receptor para el factor de crecimiento con actividad tirosin kinasa (c-kit anómalo que condiciona su activación permanente y un crecimiento celular incontrolado. Tienen una baja supervivencia en casos de enfermedad avanzada, con escasa respuesta a los agentes quimioterápicos tradicionales. El imatinib es un fármaco inhibidor de la tirosín kinasa y un ejemplo de terapia oncológica selectiva que condiciona un importante aumento en la supervivencia de estos pacientes. Se presentan 2 casos de enfermedad metastásica con buena respuesta a imatinib, así como una revisión sobre la fisiopatología y evolución en el tratamiento de este tipo de tumores, incluyendo resultados de estudios en fase III.

  7. Prinses Diana als postmoderne beilige en een kerkdienst in een museum: Tendensen in de dynamiek van cultus en cultuur vanuit een West-Europees perspectief

    Directory of Open Access Journals (Sweden)

    M. Barnard

    2001-08-01

    Full Text Available The publication of a new service book of the reformed and Lutheran churches in the Netherlands, and of a new liturgical handbook, have given the science of liturgy in that country a new impulse. The development of the discipline is focused on a cultural-anthropological perspective as well as on a reflection of the discipline in itself. In this article, two illustrating examples of four dimensions in this dynamism are given. The four dimensions are then discussed. These four dimensions are: 1. the popularity of rituals and symbols; 2. the interference of different systems of meaning; 3. the restoration of the two domains of art and liturgy into the one domain of imagination; and 4. the (sometimes radical recontextualisation of liturgy. These dimensions of liturgy are all tendencies in the dynamism of cult and culture, and to understand them, it is necessary to use cultural-anthropological methods in the science of liturgy.

  8. Diana Auth, Eva Buchholz, Stefanie Janczyk (Hg.: Selektive Emanzipation. Analysen zur Gleichstellungs- und Familienpolitik. Opladen u.a.: Verlag Barbara Budrich 2010.

    Directory of Open Access Journals (Sweden)

    Maria Wersig

    2010-07-01

    Full Text Available Im vorliegenden Sammelband wird die Gleichstellungs- und Familienpolitik der Großen Koalition aus feministisch-politikwissenschaftlichen Perspektiven analysiert. Die Beiträge geben einen Überblick über wichtige politische Entwicklungslinien der letzten Jahre und bieten kritische Perspektiven auf der Grundlage unterschiedlicher methodischer und theoretischer Zugänge. Im Zentrum stehen die Auswirkungen politischer Reformen auf unterschiedliche Gruppen von Frauen und Männern sowie Analysen der Bedeutung der Geschlechterverhältnisse im Zusammenwirken mit anderen Diskriminierungskategorien in politischen Prozessen. Ergänzt werden die Auseinandersetzungen mit dem deutschen Status quo durch drei Beiträge, welche europäische Entwicklungen in ihre Überlegungen einbeziehen.The collected volume at hand analyses equality and family politics of the Grand Coalition from the perspective of feminism and political science. The contributions provide an overview of the important political developments charted in recent years and offer critical perspectives that are based on different methodological and theoretical approaches. Central to the volume are the effects of political reforms on different groups of women and men as well as analyses of the meaning of gender relations in conjunction with other categories of discrimination in political processes. The volume expands on the examination of the German status quo in three contributions, which include also European developments in their considerations.

  9. Uso de las cáscaras de papa como coagulante natural en el tratamiento de aguas potables de la planta ”La Diana"

    OpenAIRE

    Alvarado Carmona, Ludyng Natalia

    2012-01-01

    Teniendo en cuenta que las industrias no aprovechan los residuos del procesamiento de la papa de la mejor forma y, por el contrario, se originan desperdicios orgánicos y una mala utilización de la biomasa, en este artículo se expone el resultado de un análisis de tipo experimental, relacionado con la evaluación de su poder coagulante en el tratamiento de aguas potables. Las partículas suspendidas confieren color y turbiedad indeseables a las aguas superficiales y el uso de agen...

  10. "Medvezhii" ugol Jevrosojuza / Jevgeni Ashihmin

    Index Scriptorium Estoniae

    Ashihmin, Jevgeni

    2007-01-01

    Regionaalminister Vallo Reimaa, Ida-Virumaa maavanem Riho Breivel, Kirde-Eesti piirivalveülem Aimar Kess, Alajõe vallavanem Natalja Varkki, Vasknarva külavanem Vadim Ivanov ja kohalik aktivist Aleksandr Petuhhov arutasid Alajõe valla ja Vasknarva küla probleeme

  11. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Franck Molina. Articles written in Journal of Biosciences. Volume 32 Issue 1 January 2007 pp 145-155 Articles. Formal TCA cycle description based on elementary actions · Pierre Mazière Nicolas Parisey Marie Beurton-Aimar Franck Molina · More Details Abstract Fulltext PDF.

  12. Piirivalve argipäev: patrullkäigud, hädaabi ja nüüd ...kaaslase otsing / Tanel Mazur

    Index Scriptorium Estoniae

    Mazur, Tanel, 1971-

    2009-01-01

    Kirde piirivalvepiirkonna ülem kolonel Aimar Köss ja Vasknarva kordoni ülem kapten Margo Kaljus räägivad piirivalvuriga juhtunud traagilise õnnetuse taustal piirivalve tööst ja ohtudest. Vt. samas: Piirivalvur jäi tööl kadunuks

  13. Desregulació proteolítica i inflamatòria tissular en l'hèrnia incisional abdominal humana paper del fibroblast com a possible factor de risc independent i nova diana terapèutica /

    OpenAIRE

    Guillem Martí, Jordi

    2013-01-01

    Abdominal incisional hernia (HI) is one of the most common complications of abdominal surgery. The large number of this type of interventions performed annually at hospitals, in addition to high incidence and recurrence rates, are responsible for a significant economic cost to the National Health System. Usually, IH is attributed to technical-related risk factors, such as the type of incision practiced or the applied closure procedure. However, there are sufficient evidences that suggest a bi...

  14. Edmund Valtmani nimeline Viljandi VI karikatuurivõistlus

    Index Scriptorium Estoniae

    2007-01-01

    Tutvustatakse võistluse paremaid töid. Peapreemiad: I - Ott Antu, II - Hugo Hiibus, III - Heiki Raudla, Urmas Nemvalts, eripreemiad - Aimar Juuse, Ott Kirotar, äramärgitud töö, Maalehe eripreemia - Reet Mängel-Juuse, äramärgitud töö, Sakala eripreemia - H. Raudla, äramärgitud tööd - H. Hiibus (3), O. Kirotar, H. Raudla, Tarmo Vaarmets, Airi Ojamets, R. Mängel-Juuse

  15. Full size testing of sheet pile walls

    NARCIS (Netherlands)

    Kuilen, J.W.G. van de; Linden, M.L.R. van der; Katsma, H.; Stolle, P.

    1996-01-01

    Azobé (Lophira alata) is widely used in timber sheet pile walls in the Netherlands. The boards in these walls are coupled and therefore load-sharing can be expected. A simulation model based on the finite element method DIANA (DIANA, 1992) was developed and load-sharing could be calculated. To check

  16. 77 FR 17494 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2012-03-26

    ..., export, and cull of excess scimitar-horned oryx (Oryx dammah), from the captive herd maintained at their...) Cotton-headed tamarin (Saguinus oedipus) Mandrill (Mandrillus sphinx) Diana monkey (Cercopithecus diana... interstate and foreign commerce, export, and cull of excess addax (Addax nasomaculatus), from the captive...

  17. Evaluación de la actividad antitumoral de nuevos compuestos metálicos y estudio de la reprogramación metabólica en cáncer de pulmón: búsquerda de nuevas dianas terapéuticas y biomarcadores diagnósticos

    OpenAIRE

    Cortés Giràldez, Roldàn

    2014-01-01

    El propósito de esta Tesis Doctoral es el de explorar nuevas posibilidades de tratamiento y de diagnóstico del cáncer de pulmón, y concretamente del cáncer de pulmón no microcítico de células con mutaciones activadoras de KRAS. Para conseguirlo, las finalidades de esta Tesis incluyen la determinación de la actividad biológica de nuevos compuestos organometálicos con actividad antitumoral, la caracterización de la reprogramación tumoral en líneas de cáncer de pulmón en la búsqueda de nuevas di...

  18. Riski üleminek müügilepingus ÜRO kaupade rahvusvahelise ostu-müügi lepingute konventsiooni ja Eesti võlaõigusseaduse eelnõu alusel : [bakalaureusetöö] / Diana Rammul ; Tartu Ülikool, õigusteaduskond ; juhendaja: Andres Vutt

    Index Scriptorium Estoniae

    Rammul, Diana

    1999-01-01

    Riskist ja riski üleminekust müügilepingus üldiselt, riski ülemineku põhimõtted, ostja kohustused kauba juhusliku kaotsimineku korral, riski üleminek kauba veo korral, riski üleminek vedamisel oleva kauba müügi korral, riski üleminek kauba veota, riski üleminek müüjapoolse lepingu olulise rikkumise korral

  19. South African Journal of Obstetrics and Gynaecology - Vol 12, No 1 ...

    African Journals Online (AJOL)

    Seroprevalence of rubella antibodies among antenatal patients in the Western Cape · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Craig Corcoran, Diana R Hardie, 26-28 ...

  20. Tants ei küsi vanust / Ille Grün-Ots, Siiri Rebane

    Index Scriptorium Estoniae

    Grün-Ots, Ille, 1960-2016

    2007-01-01

    Kanal 2 menusaate "Tantsud tähtedega" järellainetuses vesteldakse artiklis seltskonnatantsust Revalia tantsukooli juhataja Merle Klandorfiga, bailatinost Dance Act direktori Georg Kodusaarega, kõhutantsust tantsuõpetaja Diana Otsinguga ja flamenkost Claudia Shevsthenkoga

  1. Tartu Keskkonnahariduse Keskuse Loodusmaja = Nature School of Tartu Environmental Education Centre

    Index Scriptorium Estoniae

    2015-01-01

    Tartu Keskkonnahariduse Keskuse Loodusmaja Lille tänav 10, valminud 2013. Arhitektuurivõistlus 2010. Arhitektid Martin Kinks, Risto Parve, Kai Süda, Margit Valma (Karisma Arhitktid), Diana Taalfeld (NU Arhitektuur). Sisearhitekt Tõnis Kalve

  2. Book Review: "Can NGOs make a difference? The challenge of ...

    African Journals Online (AJOL)

    Anthony J. Bebbington, Samuel Hickey and Diana C. Miltin, eds.,"Can NGOs Make a Difference? The Challenge of Development Alternatives". London, Zed Books, 2008. Reviewed by Kirk D. Helliker Department of Sociology Rhodes University Grahamstown South Africa ...

  3. Merimetsas uuriti moekunsti ravitoimet / Anne Vetik

    Index Scriptorium Estoniae

    Vetik, Anne

    2006-01-01

    Merimetsa Tugikeskuse erivajadustega kliendid valmistasid rahvusvahelise disainiprojekti raames rõivaid. Tehtud fotodest pannakse kokku moeteraapiat tutvustav näitus. Eestvedajaks kunstnik Sirja-Liisa Vahtra, Pariisis elav fotograaf Diana Lui ja rootsi disainer Otto von Busch

  4. Tantsupäev toob publiku ette säravaid balletitähti / Raimu Hanson

    Index Scriptorium Estoniae

    Hanson, Raimu, 1957-

    2006-01-01

    29. apr. esinevad Vanemuises rahvusvaheliselt tuntud tantsijad - Tamara Rojo, Jan-Erik Wikström, Inaki Urlezaga, Anna Valev, Olga Volobujeva, Priit Kripson, Diana Cuni ja Kristoffer Sakurai -, et tähistada rahvusvahelist tantsupäeva

  5. MOOC Blended learning ontwikkelen

    NARCIS (Netherlands)

    Verjans, Steven

    2015-01-01

    Presentatie over het ontwerpen van leeractiviteiten (learning design) tijdens de zesde live sessie van de MOOC Blended learning ontwikkelen. Met gebruikmaking van presentatiematerialen van Diana Laurillard, Grainne Conole, Helen Beetham, Jos Fransen, Pieter Swager, Helen Keegan, Corinne Weisgerber.

  6. The public of media events

    Directory of Open Access Journals (Sweden)

    Christian Morgner

    2011-06-01

    The article examines different types of semantic inclusion, with a focus on emotional reactions towards three different media events: the Titanic disaster, the assassination of John F. Kennedy, and the death of Princess Diana.

  7. Popmuusika / Margus Haav

    Index Scriptorium Estoniae

    Haav, Margus, 1969-

    2006-01-01

    Uutest heliplaatidest Agent M "Šokolaad EP", Diana Krall "From This Moment On", julio Iglesias "Romantic Classic", My Chemical Romance "The Black Parade", The Glove "Blue Sunshine", Level 42 "Retrogide", Stereotyp "Keepin'Me"

  8. Plaadid / Brigitta Davidjants

    Index Scriptorium Estoniae

    Davidjants, Brigitta, 1983-

    2006-01-01

    Uutest heliplaatidest Sting "Songs From The Labyrinth", Jamelia "Walk With Me", Diana Krall "From This Moment On", Evanescene "The Open Door", Ursula "Armastan end aeglaselt", t.A.T.u. "The Best", Sandi Thom "Smile..."

  9. Books | Page 9 | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    . Over the past two decades, how has urban agriculture changed in sub-Saharan Africa? Is city farming now better integrated into environmental management and city governance? Editor(s): Gordon Prain, Nancy Karanja, and Diana Lee-Smith.

  10. African Urban Harvest: Agriculture in the Cities of Cameroon, Kenya ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2010-01-01

    . Book cover African Urban Harvest: Agriculture in the Cities of Cameroon, Kenya and Uganda. Editor(s):. Gordon Prain, Nancy Karanja, and Diana Lee-Smith. Publisher(s):. Springer, CIP, IDRC. January 1, 2010. ISBN: 9781441969620.

  11. Plaadid / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2002-01-01

    Uutest plaatidest Suede "A New Morning", Maria Kirsi "Burning Flame", Jüri Homenja "Hommennium III", "Dogtown ans Z-Boys", Diana King "respect", No Angels "Now...Us!", Default "The Fallout", Steve Earle "Jerusalem"

  12. Raamatud

    Index Scriptorium Estoniae

    2006-01-01

    2006. a. Tallinnas TEA Kirjastuselt ilmunud Ira Diana Mazzoni raamatust "Aiad ja pargid : aiakunst antiigist tänapäevani" ja kirjastuselt Tänapäev ilmunud Mairo Rääski koostatud raamatust "Eesti sillad"

  13. Melbourne Eesti Ühing Kodu aasta peakoosolek / Sirje Jõgi

    Index Scriptorium Estoniae

    Jõgi, Sirje

    2007-01-01

    18. märtsil, ühingus on 209 liiget ja viis auliiget. Esitati aruanded, valiti uus 9 liikmeline juhatus: Bruno Metsar, Glory Toom, Milvi Vaikma, Sirje Jõgi, Rolf Luik, Imbi Knappstein, Rein Valling, Diana Ritchie ja Siiri Taveter

  14. Expedient

    Directory of Open Access Journals (Sweden)

    Fernando de Assis Rodrigues

    2017-07-01

    Full Text Available Expedient of Volume 3, Issue 1 from the year 2017EDITORIAL STAFFEditorsDiana Vilas Boas Souto AleixoFernando de Assis RodriguesEditorial ComissionDiana Vilas Boas Souto AleixoFernando de Assis RodriguesRicardo César Gonçalves Sant’AnaExecutive ComissionPedro Henrique Santos BisiAd hoc peer reviewersAna Carolina Simionato, Universidade Federal de São Carlos (UFSCarDiana Vilas Boas Souto Aleixo, Universidade Estadual Paulista (UNESPElaine Parra Affonso, Faculdade de Tecnologia de Presidente Prudente (FATEC - Universidade Estadual Paulista (UNESPElvio Gilberto da Silva, Universidade do Sagrado Coração (USCFábio Mosso Moreira, Universidade Estadual Paulista (UNESPThais Batista Zanineli, Universidade Estadual de Londrina (UELText reviewersDiana Vilas Boas Souto Aleixo, Universidade Estadual Paulista (UNESPElizabete Cristina de Souza Aguiar Monteiro (UNESP

  15. Plaadid / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2002-01-01

    Uutest plaatidest David Guetta "Just A Little More Love", Bond "Shine", Chris de Burgh "Timing Is Everything...", Diana Krall "Live In Paris", Richard Ascroft "Human Conditions", Rein Laaneorg "Teine elu", Leaves "Breathe", Derek Trucks Band "Jouful Noise"

  16. For Children Only.

    Science.gov (United States)

    Marcus, Clare Cooper

    2001-01-01

    Illustrates how a London playground dedicated to Princess Diana's memory challenges the preconceptions on which most American playgrounds are designed. The playground's layout and theme are described, and several photographs are included. (GR)

  17. Eesti Ajaloomuuseumi väliekspositsioon "Klooga laager ja holokaust" = Outdoor exhibition of the Estonian History Museum "Klooga camp and the holocaust"

    Index Scriptorium Estoniae

    2015-01-01

    Eesti Ajaloomuuseumi väliekspositsioon "Klooga laager ja holokaust" Kloogal, valminud 2013. Arhitektuuri sihtkapitali maastikuarhitektuuripreemia 2013. Arhitektuurne idee ja projekteerimine Mari Rass, Diana Taalfeld ja EA Reng. Kuraator Olev Liivik, konsultandid Ruth Bettina Birn, Tõnis Liibek, Meelis Maripuu

  18. ¿Cómo se concibe la aventura?

    Directory of Open Access Journals (Sweden)

    Alicia Fajardo M.

    1989-01-01

    Full Text Available La tortuga desdentada. Alfonso Lobo Amaya. Edilux, Medellín, 1988, 16 págs. (Ilustraciones de Pilar Pabón Z .. El maravilloso viaje de Rosendo Bucurú. Celso Román. Carlos Valencia Editores, Bogotá, 96 págs. (Ilustraciones de Diana Castellanos. Una a ventura en el papel. Roberto Rubiano Vargas. Carlos Valencia. Editores, Bogotá, 1988, 104 págs. (Ilustraciones de Diana Castellanos

  19. The cult of the Regal woman in the West and in Russia: modern innovations and the old problems

    OpenAIRE

    Nikolsky Evgeny Vladimirovich

    2014-01-01

    The article analyzes squatter cults of the Royal women (Princess Diana, Queen Mary Stuart, Tsarevna Sofia). These cults are treated with religious positions. It concludes that the cult of Sofia is outwardly neo-pagan nature and is not approved by the Church authorities, yet it contains the explicit Christian component, and the official canonization of the Tzarevna is possible in future. The situation with the veneration of Mary Stuart is similar. But the perception of Diana as a sacred objec...

  20. Field Research in Political Science Practices and Principles

    DEFF Research Database (Denmark)

    Gravier, Magali

    2017-01-01

    Book review of: Kapiszewski (Diana), Maclean (Lauren M.), Read (Benjamin L.) ­ Field Research in Political Science. Practices and Principles. ­ Cambridge, Cambridge University Press, 2015 (Strategies for Social Inquiry). XIV + 456 p. Figures. Annexe. Bibliogr. Index.......Book review of: Kapiszewski (Diana), Maclean (Lauren M.), Read (Benjamin L.) ­ Field Research in Political Science. Practices and Principles. ­ Cambridge, Cambridge University Press, 2015 (Strategies for Social Inquiry). XIV + 456 p. Figures. Annexe. Bibliogr. Index....

  1. 25 years of service at CERN

    CERN Multimedia

    2014-01-01

    The 28 staff members having achieved 25 years of service at CERN in 2014 were invited by the Director-General to a reception in their honour on 25 November 2014.       Alberto AIMAR IT   Patrick BERLINGHI  GS   Horst  BREUKER  PH   Paolo  CHIGGIATO  TE   Jorgen  CHRISTIANSEN PH   Ivan  DELOOSE  IT   Martine   DESNYDER-IVESDAL  PH   Laurent  DUCIMETIERE   TE   Bruno  DUPUY  BE   Alan James  FINDLAY  BE   Jean-Jacques   GRAS BE   Michael  HAUSCHILD PH   Erk  JENSEN  BE   Michael  LAMONT&...

  2. Sofia Ionescu, the first woman neurosurgeon in the world.

    Science.gov (United States)

    Ciurea, Alexandru-Vlad; Moisa, Horatiu Alexandru; Mohan, Dumitru

    2013-11-01

    The authors present the activity of Mrs. Sofia Ionescu, the one female surgeon who was nominated as the first woman neurosurgeon in the world. Sofia Ionescu worked in the field of neurosurgery for 47 years, performing all the known neurosurgical procedures of the time. She made herself known through her incredible surgical skill and her enormous work power. Due to her incredible modesty and workload, she never participated at international congresses or manifestations. The nomination as first woman neurosurgery took place in Marrakech, Morocco, during the 2005 WFNS Congress. Although some claim that Diana Beck was the first woman neurosurgeon in the world, our theory suggests otherwise. The first documented surgical intervention performed by Diana Beck dates to 1952. Sofia Ionescu operated for the first time on a human brain as early as 1944. Furthermore, Diana Beck's actions surfaced in the year 1947, long after the war had ended and Sofia Ionescu had become a neurosurgeon. Copyright © 2013. Published by Elsevier Inc.

  3. The cult of the Regal woman in the West and in Russia: modern innovations and the old problems

    Directory of Open Access Journals (Sweden)

    Nikolsky Evgeny Vladimirovich

    2014-07-01

    Full Text Available The article analyzes squatter cults of the Royal women (Princess Diana, Queen Mary Stuart, Tsarevna Sofia. These cults are treated with religious positions. It concludes that the cult of Sofia is outwardly neo-pagan nature and is not approved by the Church authorities, yet it contains the explicit Christian component, and the official canonization of the Tzarevna is possible in future. The situation with the veneration of Mary Stuart is similar. But the perception of Diana as a sacred object has a clear pagan character.

  4. Identificación de nuevos mecanismos moleculares del inmunosupresor FK506 en Saccharomyces cerevisiae

    OpenAIRE

    Rodríguez Hernández, Carlos Javier

    2006-01-01

    El inmunosupresor FK506 (Tacrolimus, Prograf) ha incrementado la tasa de supervivencia del trasplante de órganos. FK506 ejerce su acción inmunosupresora mediante la inhibición de la fosfatasa calcineurina en células T activadas. Desgraciadamente, la terapia con FK506 está asociada con efectos no terapéuticos indeseados, entre los que destaca la diabetes, que implican otras dianas distintas de calcineurina. Para identificar estas dianas hemos estudiado la toxicidad celular de FK506 en la levad...

  5. 76 FR 66954 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2011-10-28

    ...). black lemur (Eulemur macaco). brown lemur (Eulemur fulvus). black and white ruffed lemur (Varecia variegate). red ruffed lemur (Varecia rubra). cotton-headed tamarin (Saguinus oedipus). Diana monkey...). black and white ruffed lemur (Varecia variagata). red ruffed lemur (Varecia rubra). black lemur (Eulemur...

  6. Parents as Leaders: The Role of Control and Discipline.

    Science.gov (United States)

    Yahraes, Herbert

    This paper reviews Diana Baumrind's studies of the effect of various types of parental control on children's behavior and concludes that a child is more likely to develop a sense of competence, responsibility, and independence if he or she is given firm and reasonable guidelines. A brief survey of Baumrind's first two studies of preschool children…

  7. Lopsakalt rahvuslik mood Pulga talus / Tanel Veenre

    Index Scriptorium Estoniae

    Veenre, Tanel, 1977-

    2009-01-01

    Eesti Moekunstnike Ühenduse näitus "Lillemotiiv moevormil" Eesti Vabaõhumuuseumi Pulga talus. Osalevad Anne Metsis, Anneliis Vabul, Diana Denissova, Monika Kisand, Juta Piirlaid, Anu Hint ja moekunsti õppejõud Yumiko Okazaki Jaapanist. Eksponeeritud rõivamudelid on kaunistatud rahvuslikest tikanditest inspireeritud stiliseeritud kujunditega

  8. Blastomycosis Mortality Rates, United States, 1990–2010

    Centers for Disease Control (CDC) Podcasts

    2015-01-05

    Diana Khuu discusses Blastomycosis Mortality Rates, United States, 1990–2010.  Created: 1/5/2015 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 1/7/2015.

  9. Penn Working Papers in Educational Linguistics, Volume 5, Number 2.

    Science.gov (United States)

    Riley, Kathryn, Ed.

    The working papers contained in this volume include the following: "Research on Language Learning; How Can It Respond to Classroom Concerns?" (Teresa Pica); "Building Rapport Through Indirect Complaints: Implications for Language Learning" (Diana Boxer); "(Bi)literacy and Empowerment: Education for Indigenous Groups in…

  10. Mõnda mõnusat teismelise tüdruku lugemislauale / Aidi Vallik

    Index Scriptorium Estoniae

    Vallik, Aidi, 1971-

    2007-01-01

    Kuuest tüdrukuteraamatust: Diana Leesalu "Kaks grammi hämaruseni", Helen Crossi "Minu armastuse suvi", Ann Brashare'i "Rändavate Pükste õeskond", Eva Ibbotsoni "Reis Merejõele", Sue Limbi "Tüdruk, 15, sarmikas, kuid sõge", Louise Rennisoni "Poisid, stringid ja ogar kass"

  11. Worldwide Emerging Environmental Issues Affecting the U.S. Military. January 2007 Report

    Science.gov (United States)

    2007-01-01

    environment/eu-seeks-global-mercury-ban/article-160845 Halting the Child Brain Drain. Why we need to tackle global mercury contamination http://www.env...by the Parties. Among them there are 3 NGO representatives: Diana Iskreva- Indigo , NGO "Earth forever", Bulgaria, nominated by Switzerland; Sergey

  12. Browse Title Index

    African Journals Online (AJOL)

    Items 301 - 350 of 943 ... Vol 22, No 1 (2018), Factors associated with parental intent not to circumcise daughters in Enugu State of Nigeria: an application of the theory of planned behavior, Abstract PDF. Cajetan I. Ilo, Sandra A. Darfour-Oduro, Jerome O. Okafor, Diana S. Grigsby-Toussaint, Ignatius O. Nwimo, Chinagorom ...

  13. Pop / Mart Juur

    Index Scriptorium Estoniae

    Juur, Mart, 1964-

    2002-01-01

    Heliplaatidest Kiss "The Very Best of Kiss". Andrew Lloyd Webber presents: "A R Rahman's Bombay Dreams". Naughty By Nature "Ilkons". Erinevad esinejad "One word one sound". Diana King "Respect". Caater "Club Space (Estonian Edition)". J.M.K.E. "Ainult planeet". Collage "Parimad lood 1970-1976". Cinematic Orchestra "Every Day". Catatonia "Greatest Hits". Boards of Canada "Geogaddi"

  14. Women and Technical Professions. Leonardo da Vinci Series: Good Practices.

    Science.gov (United States)

    Commission of the European Communities, Brussels (Belgium). Directorate-General for Education and Culture.

    This document profiles programs for women in technical professions that are offered through the European Commission's Leonardo da Vinci program. The following programs are profiled: (1) Artemis and Diana (vocational guidance programs to help direct girls toward technology-related careers); (2) CEEWIT (an Internet-based information and…

  15. Good/Bad Girls Read Together: Pre-Adolescent Girls' Co-Authorship of Feminine Subject Positions during a Shared Reading Event.

    Science.gov (United States)

    Enciso, Patricia E.

    1998-01-01

    Discusses reading with pre-teens Francine Pascal's "Sweet Valley Twins: Best Friends," one of a series of pre-romance novels featuring identical twin sisters. Interviews six girls using the Symbolic Representation Interview (SRI) about the good girl/bad girl dichotomy in novels and other media. Provides comments by Tom Romano and Diana Mitchell.…

  16. Kunsti kuumtöötlus Läti aladel / Mari Sobolev

    Index Scriptorium Estoniae

    Sobolev, Mari, 1968-

    2004-01-01

    Pedvale vabaõhumuuseumis toimunud rahvusvahelisest workshop'ist teemal "Kompost", mille tulemusi presenteeriti 6. VIII 2004. Ignas Kazakeviciuse, Jurate Rakeviciute, Diana Dimzha-Dime, Ule Björn Gundermanni, Remo Randveri, Maris Grosbahsi, Andrus Joonase töödest

  17. História das Culturas Escolares no Brasil

    OpenAIRE

    André Paulilo

    2012-01-01

    VIDAL, Diana Gonçalves, SCHWARTZ, Cleonara Maria (Org.). História das Culturas Escolares no Brasil. Vitória: Edufes, 2011. (Coleção: Horizontes da Pesquisa em História da Educação no Brasil, 1).

  18. Where Are All the Black Teachers? Discrimination in the Teacher Labor Market

    Science.gov (United States)

    D'amico, Diana; Pawlewicz, Robert J.; Earley, Penelope M.; McGeehan, Adam P.

    2017-01-01

    In this article, Diana D'Amico, Robert J. Pawlewicz, Penelope M. Earley, and Adam P. McGeehan examine the racial composition of one public school district's teacher labor market through teacher application data and subsequent hiring decisions. Researchers and policy makers have long noted the lack of racial diversity among the nation's public…

  19. cd4+ and cd8+ t-cells expressing interferon gamma in active ...

    African Journals Online (AJOL)

    USER

    2017-10-25

    Oct 25, 2017 ... tuberculosis live in South East Asia and West Pacific with three hundred and sixty thousand of those are Human. Immunodeficiency Virus (HIV) positive. ..... Prezzemolo Teresa, Guggino Giuliana, Manna Marco Pio La, Liberto Diana Di, Dieli Francesco & Caccamo Nadia. (2014). Functional signatures of ...

  20. Land & Development in Latin America: Issues and Openings for ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Land & Development in Latin America: Issues and Openings for Policy Research. Book cover Land & Development in Latin America: Issues and Openings for Policy Research. Auteur(s) : Stephen Baranyi, Carmen Diana Deere, and Manuel Morales. Maison(s) d'édition : North-South Institute, IDRC. 1 janvier 2004. ISBN :.

  1. Rokiklubis kuuleb punki, bluusi ja rock'n'roll'i / Anniki Leppik

    Index Scriptorium Estoniae

    Leppik, Anniki

    2008-01-01

    Üritusest "Anarchy In The EST 2008" 2. mail Pärnu rokiklubis aadressil Papiniidu 50), esinejateks bändid Flowers Of Romance, Dirty Diana, HuuliGäänz ja Gang Bang Cafe, 3 mail esinemas bändid Route 60 ja Pickups, 16. mail Sõpruse Puiestee

  2. Mingem üles mägedele / Virve Liivanõmm

    Index Scriptorium Estoniae

    Liivanõmm, Virve

    2007-01-01

    Riigikokku kandideerivad õpetaja Ülle Varik ning koolidirektorid Märt Sults, Diana Beltadze, Ivo Eesmaa ja Raimu Pruul käsitlevad haridusega seotud probleeme. Õpetajad Kalmer Hütt, Mercedes Merimaa, Igor Jallai ja koolidirektor Toomas Takkis vastavad küsimusele, miks nad kandideerivad Riigikokku

  3. Uus Tartu Loodusmaja = The new Tartu Nature Building / Tiit Sild

    Index Scriptorium Estoniae

    Sild, Tiit, 1977-

    2010-01-01

    Tartu Loodusmaja avalikust arhitektuurivõistlusest, kvalifitseerimistingimustest, energiatõhususest ja žürii tööst. 1. preemia sai töö "Känd", autorid Diana Taalfeld, Kai Süda, Margit Valma, Martin Kinks (Urmas Lõokese AB / Karisma Arhitektid). Nimetatud 2. ja 3. koha saanud tööd, autorid

  4. Litsid ja kunstnikud näitusesaalis / Teet Veispak

    Index Scriptorium Estoniae

    Veispak, Teet, 1955-

    2007-01-01

    Näitusest "Kehaturg" Tallinna Kunstihoones, kuraator Reet Varblane. Liina Siibi videost "Vastumeelne keha", soome kunstniku Teemu Mäki väljapanekust "Prostitutsioonist", malaisia fotograafi Diana Lui fotoseeriast, rootsi-eesti fotograafi Bie Erenurme väljapanekust "Mu ema on lits", Sandra Jõgeva näitusel eksponeeritud šokolaadiümbristest

  5. An Atlas of Type I MADS Box Gene Expression during Female Gametophyte and Seed Development in Arabidopsis[W].

    NARCIS (Netherlands)

    Bemer, M.; Heijmans, K.; Airoldi, C.A.; Davies, B.; Angenent, G.C.

    2010-01-01

    Members of the plant type I MADS domain subfamily have been reported to be involved in reproductive development in Arabidopsis (Arabidopsis thaliana). However, from the 61 type I genes in the Arabidopsis genome, only PHERES1, AGAMOUS-LIKE80 (AGL80), DIANA, AGL62, and AGL23 have been functionally

  6. Ready, set, hired: a practical guide to starting a career with the Canadian government

    National Research Council Canada - National Science Library

    Seems, Charles

    2008-01-01

    ... Mooney, for helping me get a foot in the door of the Recourse Branch of the Public Service Commission. Over the years, this experience has proved invaluable. To Diana Larivière-Caw, for providing me help and support in starting my private HR consulting firm. To Claudette Seems and Tracy Seems, respectively my sister and my niece, who have both followed...

  7. Making Matter Making Us: Thinking with Grosz to Find Freedom in New Feminist Materialisms

    Science.gov (United States)

    Jackson, Alecia Youngblood

    2013-01-01

    In this paper, I offer a very close reading of Grosz [2010. "Feminism, Materialism, and Freedom." In "New Materialisms: Ontology, Agency, and Politics," edited by Diana Coole and Samantha Frost, 139-157. Durham, NC: Duke University Press] thinking with Bergson in order to re-conceptualise freedom, matter, and the subject in new…

  8. 76 FR 55070 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2011-09-06

    ... cancer in animals; it is unknown if the same is true in humans. A significant need remains for a means of... available (animal). Inventors: Christopher Buck and Diana Pastrana (NCI). Publication: In preparation....nih.gov . A Novel Optomechanical Module that Enables a Conventional inverted Microscope To Provide...

  9. Vene kirjandusest balti aktsendiga

    Index Scriptorium Estoniae

    2006-01-01

    24. nov. esitletakse Tallinnas Kirjanike majas almanahhi "Tuulelohe : vene kirjandus balti aktsendiga" ("Vozdushnõi zmei. Russkaja literatura s baltiiskim aktsentom"). Esinevad P. I. Filimonov, Deniss Kuzmin, Diana Efendijeva, Larissa Joonas, Dmitri Krasnov, Irina Meljakova, Jashka Gromova. Õhtut juhib almanahhi toimetaja Igor Kotjuh

  10. Browse Title Index

    African Journals Online (AJOL)

    Items 701 - 736 of 736 ... Vol 14, No 4 (2017), Utilitarian theatre forms and their relatedness: the imperative of conceptual clarifications, Abstract. Edward Ugbada Adie. Vol 14, No 2 (2017), Utilitarianism as a Veritable Vehicle for the Promotion of a Just Society, Abstract. Ephraim A. Ikegbu, Francis I. Diana-Abasi. Vol 8, No 3 ...

  11. Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (85th, Miami, Florida, August 5-8, 2002). Media Ethics Division.

    Science.gov (United States)

    2002

    The Media Ethics division of the proceedings contains the following 6 papers: "A Masochist's Teapot: Where to Put the Handle in Media Ethics" (Thomas W. Hickey); "Stalker-razzi and Sump-pump Hoses: The Role of the Media in the Death of Princess Diana" (Elizabeth Blanks Hindman); "The Promise and Peril of Anecdotes in News…

  12. Technology, Education, and the Changing Nature of Resistance.

    Science.gov (United States)

    Rickard, Wendy

    1999-01-01

    Discusses information technology in higher education. Includes comments from Educom Medal Awards winners honored for contributions made to improving undergraduate education through information technology: Paul Velleman, Cornell; Diana Eck, Harvard; Richard Larson, Stony Brook; David Fulker, University Corporation; and Stephen Ressler, Military…

  13. Tähtis on hoida ühtset joont / Agne Adamson

    Index Scriptorium Estoniae

    Adamson, Agne

    2011-01-01

    Eesti Perearstide Seltsi 2008. a. valitud juhatuse tööst kolme aasta vältel ning tulevikuvisioonidest. Vestlusringis osalesid Ruth Kalda, Diana Ingerainen, Madis Tiik, Eret Jaanson, Anneli Talvik, Katrin Martinson ja Külvi Peterson. Kommentaarid EPS-i liikmetelt

  14. Combinando la ciencia y los conocimientos locales para mejorar la ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Clara Piñeros, Diana Duarte, Yogendra Kalenahalli, Stan Kubow, Teresa Mosquera y Ajjamada Kushalappa. Combinando la ciencia y los conocimientos locales para mejorar la seguridad alimentaria. Historias de cambio. Mensajes claves. • Los investigadores identificaron nuevos genes resistentes a la enfermedad tizón.

  15. Procedure Transparency in the Taiwan Fair Trade Commission

    OpenAIRE

    Diana Tsai

    2015-01-01

    From the standpoint of business planning, two dimensions of procedure transparency are worth noting in the TFTC—in clearing legal criteria and during the decision-making process. Diana H.A. Tsai (Taiwan Fair Trade Commission & National Chiao Tung University)

  16. Rethinking "Harmonious Parenting" Using a Three-Factor Discipline Model

    Science.gov (United States)

    Greenspan, Stephen

    2006-01-01

    Diana Baumrind's typology of parenting is based on a two-factor model of "control" and "warmth". Her recommended discipline style, labeled "authoritative parenting", was constructed by taking high scores on these two factors. A problem with authoritative parenting is that it does not allow for flexible and differentiated responses to discipline…

  17. Marr: Magpie or Marsh Harrier? The Quest for the Common Characteristics of the Genus "Historian" with 16- to 19-Year-Olds

    Science.gov (United States)

    Laffin, Diana

    2012-01-01

    Diana Laffin writes about historical language and explores how understanding different historians' use of language can help sixth form students refine and deepen both their understanding of the discipline of history and their abilities to practise the discipline in their own writing. What does close study of the textual habits and practices of…

  18. Books | Page 33 | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    For the urban poor of the South, food is becoming a prohibitively expensive commodity. By the late 1980s, cities of the developing world had to import half their food supply. Author(s): Auxumite G. Egziabher, Diana Lee-Smith, Daniel G. Maxwell, Pyar Ali Memon, Luc J.A. Mougeot, and Camillus J. Sawio. Publisher(s): IDRC.

  19. Latin cults through Roman eyes : Myth, memory and cult practice in the Alban hills

    NARCIS (Netherlands)

    Hermans, A.M.

    2017-01-01

    This thesis studies the role of the Latin past in the Roman present, by investigating three large sanctuaries in the Alban hills: that of Diana Nemorensis, Juno Sospita and Jupiter Latiaris. The Alban hills are volcanic highlands southeast of Rome, which are located in the heart of Latium Vetus

  20. Concursos

    Directory of Open Access Journals (Sweden)

    Boletín Cultural y Bibliográfico Banco de la República

    1986-10-01

    Full Text Available Se presenta la información y bases de los siguientes premios y concursos: VII Concurso de poesía Universidad de Antioquia 1986; Premio novela: Novedades y Diana; Premio Internacional Gabriela Mistral 1987; Becas en el exterior para artistas Un músico, un cantante, un artista plástico.

  1. Peeter I residentsid / Jüri Kuuskemaa

    Index Scriptorium Estoniae

    Kuuskemaa, Jüri, 1942-

    2005-01-01

    Peeter I linnaresidents Tolli t. 4 Tallinnas, maja (1662, 1714) ning lossi- ja pargiansambel (1718, arhitekt Niccolo Michetti, 1923. aasta sügisest ehitusel vastutav Mihhail Zemtsov, stukk Antonio Quadri, Salomon Zeltrecht, Matthias Seidtinger, Heinrich von Bergen, laemaal "Diana ja Aktaion" - Ernst Wilhelm Londicer noorem?, laemaaling merepoolses tiibhoones - Johann Heinrich Fick) Kadriorus. Bibliograafia lk. 454

  2. Abraham Lincoln and the Pillars of Liberty

    Science.gov (United States)

    Schaub, Diana J.

    2002-01-01

    In this essay, Diana Schaub, associate professor and chair of the Department of Political Science at Loyola College in Maryland, asserts that the 9/11 attack on America showed students the fallacy not of relativism, but of toleration. They are now aware that there are limits to toleration. By giving such a vivid display of the horrors of…

  3. Selgusid Betti Alveri preemia nominendid

    Index Scriptorium Estoniae

    2005-01-01

    Betti Alveri kirjandusauhinna nominendid: Sass Henno "Mina olin siin", Andrei Hvostovi "Lombakas Achilleus", Mart Kanguri, Jaak Ranna ja Ivar Ravi "Jaak Rand ja teisi jutte", Diana Leesalu "2 grammi hämaruseni", Jaan Pehki "Sisukord", Linnar Priimäe "Kelle tee on varjul", Leo de Sixtuse "Skarabeuse tsivilisatsioon". Vt. ka Eesti Päevaleht, 16. nov., lk. 15

  4. Betti Alveri sünniaastapäeval kuulutatakse välja järjekordne Alveri kirjandusauhinna saaja...

    Index Scriptorium Estoniae

    2005-01-01

    Kirjandusauhinna nominendid: Sass Henno. Mina olin siin ; Andrei Hvostov. Lombakas Achilleus ; Mart Kangur, Jaak Rand ja Ivar Ravi. Jaak Rand ja teisi jutte ; Diana Leesalu. 2 grammi hämaruseni ; Jaan Pehk. Sisukord ; Linnar Priimägi. Kelle tee on varjul ; Leo de Sixtus. Skarabeuse tsivilisatsioon

  5. Assessment of Phaseolus vulgaris L and Vigna unguiculata (L ...

    African Journals Online (AJOL)

    ... (L.) Walp leaves for antifungal metabolites against two bean fungal pathogens Colletotricum lindemuthianum and Phaeoisariopsis griseola. Diana Alexandra Norena-Ramirez, Oscar Julian Velasguez-Ballesteros, Elizabeth Murillo-Perea, John Mendez-Arteaga, Joze Fernando Solanilla-Duque, Walter Murillo-Arango ...

  6. Republic of Noise: The Loss of Solitude in Schools and Culture

    Science.gov (United States)

    Senechal, Diana

    2011-01-01

    In "Republic of Noise," Diana Senechal confronts a culture that has come to depend on instant updates and communication at the expense of solitude. Where once it was common wisdom that the chatter of the present, about the present, could not always grasp the present, today we treat "real time" as though it were the only real time. Schools…

  7. Vaid klaas vett päevas / Kadri Kalda

    Index Scriptorium Estoniae

    Kalda, Kadri

    2013-01-01

    Rahvusvahelisest koostööprojektist Ghana St Raphaeli algkooli, Valga gümnaasiumi ja EBS-i gümnaasiumiga teemal „Vesi ja sanitaartingimused”. Abistas Põhja-Ghanas Kongo külas töötanud MTÜ Mondo vabatahtlik Diana Tamm

  8. The membranotropic activity of N-terminal peptides from the pore ...

    Indian Academy of Sciences (India)

    ... activity of N-terminal peptides from the pore-forming proteins sticholysin I and II is modulated by hydrophobic and electrostatic interactions as well as lipid composition. Uris Ros Lohans Pedrera Daylín Díaz Juan C De Karam Tatiane P Sudbrack Pedro A Valiente Diana Martínez Eduardo M Cilli Fabiola Pazos Rosangela ...

  9. Modelling and measuring the dynamics of scientific communication

    NARCIS (Netherlands)

    Lucio-Arias, D.

    2010-01-01

    Het belang van kennis in onze moderne maatschappij heeft wereldwijd de aandacht van beleidsmakers. Wetenschappelijke ontwikkeling laat tekstuele sporen na in de vorm van publicaties in onder meer wetenschappelijke bladen, boeken en conferenties. Diana Lucio-Arias onderzocht deze tekstuele sporen om

  10. Sex Differences in the Development of Moral Reasoning: A Rejoinder to Baumrind.

    Science.gov (United States)

    Walker, Lawrence J.

    1986-01-01

    Addresses the criticisms of Diana Baumrind's review of his research on sex differences in moral reasoning development. Discusses issues such as the nature of moral development, the focus on adulthood, the choice of statistics, the effect of differing sample sizes and scoring systems, and the role of sexual experiences in explaining variability in…

  11. Handbook of Parenting. Volume 5: Practical Issues in Parenting. Second Edition.

    Science.gov (United States)

    Bornstein, Marc H., Ed.

    Concerned with practical aspects of meeting children's needs, this volume, the fifth of five on parenting, describes the nuts and bolts of parenting as well as the promotion of positive parenting practices. The volume consists of the following 19 chapters: (1) "The Ethics of Parenting" (Diana Baumrind and Ross A. Thompson; (2) "Parenting and…

  12. Analysis of Parental Involvement and Self-Esteem on Secondary School Students in Kieni West Sub-County, Nyeri County, Kenya

    Science.gov (United States)

    Wairimu, Mburu Josephine; Macharia, Susan M.; Muiru, Ann

    2016-01-01

    This study investigated the relationship between parental involvement and the self-esteem among adolescents in secondary school students in Kieni West District in Nyeri County. It was guided by Self Determination Theory (SDT) by James William and Baumrind Theory of Parenting Styles by Diana Blumberg Baumrind. Some of the gaps identified in the…

  13. 78 FR 18612 - Proposed Collection; 60-Day Comment Request; Web-based Media Literacy Parent Training for...

    Science.gov (United States)

    2013-03-27

    ... Comment Request; Web-based Media Literacy Parent Training for Substance Use Prevention in Rural Locations..., mechanical, or other technological collection techniques or other forms of information technology. To Submit..., contact Dr. Augie Diana, Health Scientist Administrator, Prevention Research Branch, Division of...

  14. Land & Development in Latin America: Issues and Openings for ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Carmen Diana Deere isProfessor of Food and Resource Economics and Director for the Center for Latin American Studies at the University of Florida, USA. Manuel Morales is Executive Director of the ECOLEX Corporation, a nongovernmental organization located in Quito, Ecuador. ? Edición español: Descargar PDF ...

  15. Noorkirjanike sulge juhivad surm, narkootikumid ja kodutus / Priit Rajalo

    Index Scriptorium Estoniae

    Rajalo, Priit, 1975-

    2006-01-01

    Kirjastuse Tänapäev ja Eesti Lastekirjanduse Teabekeskuse noorte romaanivõistluse võidutööd: I koht - Diana Leesalu "Mängult on päriselt", II koht - Mare Sabolotny "Kirjaklambritest vöö", III koht - Hele-Riin Moon "Mina, Mortimer" ja Ketlin Priilinn "Maarjamäe kägu"

  16. H2O in Protoplanetary Disks : The Snow Line and the Planets' Nest

    NARCIS (Netherlands)

    Antonellini, Stefano; Kamp, Inga; Woitke, Peter; Thi, Wing-Fai

    2013-01-01

    Protoplanetary disks represent the stage between the pre-stellar collapse of the molecolar cloud and the formation of a planetary system surrounding a main sequence star. The goal of the DIANA FP7 project (P.I.: P.Woitke) is to investigate the disks in multiwavelengths, considering available data of

  17. Õpilaskodude plussid ja miinused / Merje Kask

    Index Scriptorium Estoniae

    Kask, Merje

    2006-01-01

    Saaremaa Ühisgümnaasiumi haldusjuht Aado Haandi, Jõgeva maakonna alaealiste komisjoni esimees Jüri Ginter, Kaelase Kooli direktor Diana Tali, Otepää Gümnaasiumi direktor Aivo Meema, Tõstamaa Keskkooli direktor Toomas Mitt, Kunda Ühisgümnaasiumi õppealajuhataja Meelike Abroi ja Krabi Põhikooli direktor Ale Sprenk õpilaskodudest

  18. Inhaloterapia en el manejo de las enfermedades respiratorias

    OpenAIRE

    Vargas-Pinilla, Olga-Cecilia; Martinez-Santa, Jaime

    2014-01-01

    El tratamiento se fundamenta en el uso de medicamentos por vía inhalada, ya que presenta grandes ventajas frente a las otras vías de administración al llegar directamente al órgano diana, por lo que se requiere menos dosis, su respuesta es más rápida y hay menos efectos adversos.

  19. Rembrandt and the Female Nude

    NARCIS (Netherlands)

    Sluijter, Eric Jan

    2006-01-01

    Rembrandt's extraordinary paintings of female nudes - Andromeda, Susanna, Diana and Her Nymphs, Danaë, Bathsheba - as well as his etchings of nude women, have fascinated many generations of art lovers and art historians, but they have also elicited vehement criticism. They were considered

  20. Alaska Inclusion Training Modules: Building Inclusive Classrooms and Schools. Modules 1-3. Second Edition.

    Science.gov (United States)

    Ryan, Susan, Ed.; Kurka, Diana, Ed.

    This document presents three inservice training modules which focus on the inclusion of students with disabilities in regular education settings in Alaska schools. Module 1, "Setting our Sights on Inclusion," by Diana Kurka, is a three-hour inservice program which provides an introduction to inclusion via sections on: legal and…

  1. Developing reading in a first-year academic literacy course

    African Journals Online (AJOL)

    KATEVG

    develop students' skills in reading academic texts and their ability to write logically and express themselves clearly. ... emphasise the crucial role played by reading proficiency when it comes to tertiary education access, one must note ..... Literacy in education: Essays in memory of Diana Feitelson. Cresskill: Hampton Press ...

  2. On the application of cohesive crack modeling in cementitious materials

    DEFF Research Database (Denmark)

    Stang, Henrik; Olesen, John Forbes; Poulsen, Peter Noe

    2007-01-01

    for a centrally cracked sheet is established applying semi-analytical, bridged and fictitious crack modeling. The semi-analytical crack model is compared with a FEM analysis and it is demonstrated, that the standard fictitious crack implementation in FEM packages (in this case DIANA) provides a good approximation...

  3. Introduction to "Multicultural Voices: Peer Tutoring and Critical Reflection in the Writing Center"

    Science.gov (United States)

    Grimm, Nancy Maloney

    2010-01-01

    In 1991 when Diana George, Ed Lotto, and the author were publishing their first issue as "WCJ" editors, this multivoiced essay struck her as a prime example of their editorial belief that writing centers could be "agents of change in the academy." As Gail Okawa and Tom Fox observe, "Most universities are inhospitable to more democratic definitions…

  4. 75 FR 17376 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2010-04-06

    ... period, NTIA will post an announcement on BroadbandUSA.gov identifying all of the Census block groups or... territories by Census block group or tract. NTIA will provide a template for submissions from service... information collection proposal can be obtained by calling or writing Diana Hynek, Departmental Paperwork...

  5. JiaZhang Dui ErTong FaZhan TongBan GuanXi De ZuoYong (The Role of Parents in the Development of Peer Group Competence). ERIC Digest.

    Science.gov (United States)

    Moore, Shirley G.

    Among studies that have examined the relationship between parenting styles and children's development of social skills, the research of Diana Baumrind is noteworthy. In several studies, she has identified authoritarian, permissive, and authoritative parenting styles, which differ on the dimensions of nurturance and parental control. Authoritarian…

  6. The Role of Parents in the Development of Peer Group Competence. ERIC Digest.

    Science.gov (United States)

    Moore, Shirley G.

    Among studies that have examined the relationship between parenting styles and children's development of social skills, the research of Diana Baumrind is noteworthy. In several studies, she has identified authoritarian, permissive, and authoritative parenting styles, which differ on the dimensions of nurturance and parental control. Authoritarian…

  7. El Papel de los Padres en el Desarrollo de la Competencia Social (The Role of Parents in the Development of Peer Group Competence). ERIC Digest.

    Science.gov (United States)

    Moore, Shirley G.

    Among studies that have examined the relationship between parenting styles and children's development of social skills, the research of Diana Baumrind is noteworthy. In several studies, she has identified authoritarian, permissive, and authoritative parenting styles, which differ on the dimensions of nurturance and parental control. Authoritarian…

  8. Screening Mammography: Science, Policy and Politics–The Good, the Bad and the Ugly

    Science.gov (United States)

    Diana Petitti, MD, MPH, FACPM, an epidemiologic expert on women's health and evidence based medicine, with posts as vice chair and spokesperson for the U.S. Preventive Service Task Force, presented "Screening Mammography: Science, Policy and Politics–The Good, the Bad and the Ugly." 

  9. Titulaires de la bourse du CRDI aux chercheurs candidats au ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    From statebuilding to localized governance: Exploring African governance structures (Uganda). Université Wilfrid Laurier, doctorat en gouvernance mondiale. ZACCA THOMAZ, Diana, Building an inclusive city from the bottom-up: marginalized migrants' struggles for adequate and affordable housing in São Paulo, Brazil.

  10. New Baltic Drama 2011 võidunäidend jõuab Linnateatri lavale

    Index Scriptorium Estoniae

    2011-01-01

    Rahvusvahelisest näidendivõistlusest, mille võidunäidendid on Martin Alguse "Kontakt" (Eesti), Pipsa Lonkka "These Little Town Blues Are Melting Away" (Soome), Semjon Kirovi "Ilja päev" (Venemaa), Johanna Emanuelssoni "Vaata, ma kukun" ("Älfsborgi sild", Rootsi). Viimast hakkab Tallinna Linnateatris lavastama Diana Leesalu

  11. Ghana Journal of Development Studies - Vol 14, No 1 (2017)

    African Journals Online (AJOL)

    Ghanaian Consumers' Attitudes toward Cisgenic Rice: Are all Genetically Modified Rice the Same? EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Francis Tsiboe, Lawton L. Nalley, Bruce L. Dixon, Diana Danforth, Anne-Cécile Delwaide, Rodolfo M. Nayga, 1-18.

  12. ¿Catastrofe o nueva sociedad? Modelo mundial latinoamericano 30 ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Amílcar O. Herrera, Hugo D. Scolnick, Gabriela Chichilinsky, Gilberto C. Gallopin, Jorge E. Hardoy, Diana Mosovich, Enrique Oteiza, Gilda L. de Romero, Carlos E. Suárez, et Luis Talavera. Maison(s) d'édition : IIED-AL, CRDI. 1 janvier 2004. ISBN : 9879803396. 156 pages. e-ISBN : 1552501442. Téléchargez le PDF.

  13. Faire campagne en ville : L'agriculture urbaine en Afrique de l'Est ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Faire campagne en ville : L'agriculture urbaine en Afrique de l'Est. Couverture du livre Faire campagne en ville : L'agriculture urbaine en Afrique de l. Auteur(s):. Auxumite G. Egziabher, Diana Lee-Smith, Daniel G. Maxwell, Pyar Ali Memon, Luc Mougeot et Camillus J. Sawio. Maison(s) d'édition: CRDI. 1 janvier 1995. ISBN :.

  14. Masculinities in Dialogue: A Response

    Science.gov (United States)

    Knights, Ben

    2011-01-01

    This response to the articles by Diana Wallace and Samantha Pinto seeks to locate the negotiation of gendered identities in the classroom within the larger study of the dialogic relations between texts, teachers, and students. Teaching, it proposes, is not a second-order derivative of scholarship, but a cultural form in its own right. The article…

  15. The Puerto Ricans: Their History, Culture, and Society.

    Science.gov (United States)

    Lopez, Adalberto, Ed.

    Articles in this book cover Puerto Rican history from the Spanish colonization to the present day experience of Puerto Ricans in the United States. Political, social, economic, cultural, and historical issues are addresed by the following authors: Edna Acosta-Belen, Frank Bonilla, Juan Manuel Carrion, Diana Christopulos, Sandra Messinger Cypess,…

  16. Concursos

    Directory of Open Access Journals (Sweden)

    Boletín Cultural y Bibliográfico Banco de la República

    1990-05-01

    Full Text Available Se presenta la información y bases de los siguientes premios y concursos: Bienal del humor y la sátira; Concurso Enka de Literatura Infantil; Concurso literario editorial Diana y novedades; Premio Eloy Valenzuela; Diseño de carátulas y comentarista de libros.

  17. Improved Intelligence Warning in an Age of Complexity

    Science.gov (United States)

    2015-05-21

    Author James Gleick describes nonlinear systems as walking in a maze in which the walls rearrange themselves with each step.128 As a result, the...Aid On the Edge of Chaos: Rethinking International Cooperation in a Complex World. Oxford: Oxford University Press, 2014. Richards, Diana Eva -Ann

  18. Kunstiakadeemia disainikonverents

    Index Scriptorium Estoniae

    2003-01-01

    8.-10. V Rotermanni soolalaos ja Eesti Kunstiakadeemias rahvusvaheline disainikonverents "VALID : VALue in Design", mille korraldab EKA koostöös rahvusvahelise kunsti-, disaini- ja arhitektuurikõrgkoolide assotsiatsiooniga CUMULUS. Peaesinejad Diana Crane, Natasha Vita-More (USA), Carlo Vezzoli (Itaalia)

  19. ¿Catastrofe o nueva sociedad? Modelo mundial latinoamericano 30 ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Couverture du livre ¿Catastrofe o nueva sociedad? Modelo mundial latinoamericano 30 años después (. Author(s):. Amílcar O. Herrera, Hugo D. Scolnick, Gabriela Chichilinsky, Gilberto C. Gallopin, Jorge E. Hardoy, Diana Mosovich, Enrique Oteiza, Gilda L. de Romero, Carlos E. Suárez, et Luis Talavera. Publisher(s):.

  20. Younger Estonian Prose / Peeter Helme

    Index Scriptorium Estoniae

    Helme, Peeter, 1978-

    2008-01-01

    Iga kahe aasta tagant korraldatavast romaanivõistlusest ning uutest ja noortest autoritest, pikemalt Indrek Harglast, Lew R. Bergist, Jaan Apsist, Joonas Sildrest, Diana Leesalust, Marion Andrast, Tiina Laanemist, Olle Laulist, Chaneldiorist, Vahur Afanasjevist, Mehis Heinsaarest, Mart Kangurist, Ivar Ravist, Jaak Rannast

  1. The Politics of Trade: The Role of Research in Trade Policy and ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2009-05-07

    May 7, 2009 ... Diana Tussie is Founding Director of the Latin American Trade Network, Director of the International Relations Department at FLACSO, the Latin American ... IDRC and the São Paulo Research Foundation (FAPESP) signed a scientific and technological cooperation agreement to support joint research ...

  2. Automation of Feynman diagram evaluations

    International Nuclear Information System (INIS)

    Tentyukov, M.N.

    1998-01-01

    A C-program DIANA (DIagram ANAlyser) for the automation of Feynman diagram evaluations is presented. It consists of two parts: the analyzer of diagrams and the interpreter of a special text manipulating language. This language can be used to create a source code for analytical or numerical evaluations and to keep the control of the process in general

  3. Working with Staff Using Baumrind's Parenting Styles Framework

    Science.gov (United States)

    Veldhuis, Hollace Anne

    2012-01-01

    The author's presentation at the staff meeting centered on Diana Baumrind's parenting styles framework (Baumrind, 1967). Baumrind believed that there were four requirements for effective guidance: nurturing, communication, maturity demands, and control. She rated parents on these four dimensions and identified the pattern of parenting that…

  4. Hay huellas en el cuerpo

    Directory of Open Access Journals (Sweden)

    Julia Bertone

    2011-12-01

    Full Text Available La presente reseña introduce y comenta el libro de los compiladores Victoria D`hers y Eduardo Galak “Estudios sociales sobre el cuerpo: prácticas, saberes, discursos en perspectiva”; el cual surge en el marco de las “VI Jornadas de Sociología de la UNLP” y consta de un prólogo realizado por Adrián Scribano y Lucas Aimar, y once artículos producidos por jóvenes investigadores en relación a los Cuerpos y las Emociones.Los autores proponen recorrer un mapeo y ensayar lecturas sobre las conexiones entre prácticas corporales, afecciones y emociones. La escritura y el modo de presentación del libro reflejan la textura de la temática y la complejidad del espacio de reflexión. Desde una sociología de los cuerpos y las emociones es posible hallar pistas que nos conduzcan a comprender el sentido que los actores dan a sus prácticas; identificar nodos conflictuales que emergen en esas comprensiones cotidianas; y dar cuenta de cómo la sociedad que se hace cuerpo, puede ser rastreada a partir del análisis de determinadas emociones sociales. Desde el título podemos reconocer que el libro deja huellas para comprender que el propio cuerpo es discusión del presente y del futuro inmediato.

  5. Application of PIXE to the study of Renaissance style enamelled gold jewelry

    Science.gov (United States)

    Weldon, M.; Carlson, J.; Reedy, S.; Swann, C. P.

    1996-04-01

    This study examines and compares three pieces of Renaissance style gold and enamelled jewelry owned by the Walters Art Gallery, Baltimore, MD, USA. These are a 16th century Hat Badge of Adam and Eve, a 19th century Fortitude Pendant and a Diana Pendant presumed to be of the 16th century (The Walters Art Gallery, Jewelry, Ancient to Modern (Viking, New York, 1979)), Ref. [1]. PIXE spectroscopy was applied to examine the elemental composition of the gold and of the enamels. Compositional differences, including the use of post-Renaissance colorants, were found between the enamels in separate regions of each of the three pieces. The modern colorant, chromium, was, in fact, found in all of the pieces and uranium was found in only the Diana Pendant. There are some differences in the gold purity of the three objects; there are significant differences in the solders used even within one object, the Fortitude Pendant.

  6. Indisciplinas sociales, su análisis desde la perspectiva metodológica del Marketing Social

    Directory of Open Access Journals (Sweden)

    MsC. Fernando Martínez -Gascón

    2015-10-01

    Full Text Available En la sociedad cubana actual, el estudio de las indisciplinas sociales se ha hecho desde la psicología y la sociología, entre otros campos; sin embargo, no se han realizado investigaciones desde la perspectiva del marketing social, el cual persigue el cambio de conductas en sus públicos diana; al presentarlo, admite integrar un conjunto de factores con el objetivo de contrarrestar actitudes y conductas negativas que alteran la convivencia social.

  7. Uncovering hidden treasures in silver trunks: the Zandra Rhodes Digital Study Collection

    OpenAIRE

    Robinson, Amy; Gramstadt, Marie-Therese

    2013-01-01

    Hidden away in silver trunks at the Zandra Rhodes Studio are over 5,000 dresses spanning fifty years of British Fashion and including designs worn by clients such as Elizabeth Taylor, Freddie Mercury, and Diana, Princess of Wales. The Zandra Rhodes Digital Study Collection, with an accompanying Open Education Resource (OER), will provide unique online access to images of 500 of the designer’s most iconic garments, for use in study and research by the next generation of fashion and textile...

  8. Rembrandt Kadrioru lossis / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2000-01-01

    Kadrioru lossi kuppelsaali tundmatu meistri laemaali maalimise ajalugu. Maali aluseks on Rembrandti maal "Diana suplus". Laemaal on maalitud Magdalena de Passe (1600-1638) vasegravüüri põhjal, mis on tehtud Rembrandti maalist. Rembrandt on lähtunud Antonio Tempesta (1555-1630) kahest gravüürist, viimane on lähtunud Otto van Veeni (1556-1629) maalist

  9. PARENTING AND ITS INFLUENCE ON CHILD BEHAVIOUR

    OpenAIRE

    Jiji Mary Antony; Suresh Sebastian Vadakedom

    2017-01-01

    BACKGROUND Parenting is the process of giving care to the young and preparing them to face the challenges of life. Diana Baumrind introduced the models of parenting, authoritative, authoritarian and permissive depending on the level of demandingness and responsiveness. Defective parenting is associated with problem behaviours in children. This study was undertaken to find out which parenting style is least associated with behavioural problems and what are the problems associated w...

  10. 75 FR 64782 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Science.gov (United States)

    2010-10-20

    ..., Naucalpan, Mexico, Mexico; R.F.C. GCC-030326-KUA (Mexico); (ENTITY) [SDNTK]. 8. LA NUMERO UNO DE CUAUHTEMOC S.A. DE C.V. (a.k.a. CANTINA LA NUMERO UNO; a.k.a. ``SALON DIANA''); Avenida Cuauhtemoc No. 150, Esq...); (INDIVIDUAL) [SDNTK]. 13. FLORES CACHO, Javier, c/o LA NUMERO UNO DE CUAUHTEMOC S.A. DE C.V., Mexico City...

  11. The Effect of Lavender Aaromatherapy on the Pain Intensity Perception and Intarapartum Outcomes in Primipare

    OpenAIRE

    N Alavi; M Nemati; M Kaviani; MH Tabaie

    2010-01-01

    1.Borli S, Diana SK. Easy Labour by Lamas Method, translation: Zein Ali Bagha E. 1st ed. Tehran: Babazadeh 1382:2. 2.Hadi N. Mother & Child Health . 1st ed. Shiraz: Navid13849. 3.Hosseinpour N. Acupuncture & tens on severity primiparous women's labour pain reffers to zeinabieh hospital of shiraz . MS thesis of nursing & midwifery college of shiraz university of medical sciences, Shiraz,1386. 4.Shariat MA, Mohammadian Mohamad A, Mahmodi M. The effect of request of pregnant women ...

  12. Cyber Practices: What Can the U.S. Air Force Learn from the Commercial Sector?

    Science.gov (United States)

    2015-01-01

    different groups? • Should employees follow standard procedures or be granted more autonomy ? 48 To...Emphasized in InfoSec We heard in many interviews that there is a strong emphasis on creativity and critical thinking skills in InfoSec. Such autonomy is...Force Personnel Center data; see Air Force Personnel Center, 2014. 81 David H. Tobey, and Portia Pusey, and Diana L. Burley, “Engaging Learners in

  13. Hemerografía

    Directory of Open Access Journals (Sweden)

    Revista Chasqui

    2015-01-01

    Full Text Available Cine, revista de apreciación cultural y cinematográfica, Nº 3, Ecuador, Diciembre 1984; Comunicación y cultura, octubre de 1984, México Nº 12; Arcadia va al cine, Año 3, Nº 8, octubre de 1984; La droga que se enchufa, La televisión, los niños y la familia, Marie Winn, Editorial Diana, México 1981; Communications et langages, Revista trimestral, Año 1984.

  14. Asia-Pacific Economic Update, 2012. Volume 3

    Science.gov (United States)

    2012-09-01

    Medeiros, James Mulvenon, and William Overholt. Modernizing China’s Military: Opportunities and Constraints. Rand Corporation. Santa Monica: 2005...Philippines-heats-up- with-travel-warnings-oil-drilling. 42 Cuneta, Josephine and James Hookway. “China Dispute Threatens Philippine Industries.” Wall...January/February 2005); 49-63. 59 Whistler , Diana, Kenneth White, S. Donna Wong, and David Bates. Shazam. (Vancouver BC: Northwest Econometrics

  15. Aire Saludable en los centros sanitarios de Asturias. Programa Marco

    OpenAIRE

    Bruno, Julio; Mosquera, Carmen

    2016-01-01

    Impreso en papel alto gramaje. 23 paginas más las portadas. INDICE Introduccion Proposito Objetivos Poblacion Diana Implantacion del Programa Ordenacion de espacios y limitacion del consumo de tabaco Potenciar las actitudes de los sanitarios hacia el abandono Otras actuaciones Evaluacion Bibliografia Hospital sin humo. Consulta preingreso Carta europea de los Hospitales sin humo ANEXO: Legislacion Framework Programme to establish smoke -free envir...

  16. The European market for organic food (Session at the BIOFACH 2017)

    OpenAIRE

    Willer, Helga; Schaack, Diana; Padel, Susanne; Lacarce, Eva; Solfanelli, Francesco

    2017-01-01

    At the session "The European market for organic food", the latest data on the European market as well as selected country markets was presented. - European organic market data 2015(Dr. Helga Willer) - The organic market in Germany - highlights 2016 (Diana Schaack) - UK organic sector and market trends 2015 and 16 (Dr. Susanne Padel) - The French organic food market (Eva Lacarce) - The Italian market for Organic food (Francesco Solfanelli)

  17. ERP correlates of source memory: Unitized source information increases familiarity-based retrieval

    OpenAIRE

    Diana, Rachel A.; Van den Boom, Wijnand; Yonelinas, Andrew P.; Ranganath, Charan

    2010-01-01

    Source memory tests typically require subjects to make decisions about the context in which an item was encoded and are thought to depend on recollection of details from the study episode. Although it is generally believed that familiarity does not contribute to source memory, recent behavioral studies have suggested that familiarity may also support source recognition when item and source information are integrated, or “unitized”, during study (Diana, Yonelinas, and Ranganath 2008). However,...

  18. Respons Pertumbuhan Hijauan Makanan Ternak terhadap Pemberian Pupuk Cair Urin Kambing Terfermentasi

    OpenAIRE

    Hadirin

    2017-01-01

    147040001 HADIRIN, Growth respone of forages by administration of fermented goat urine. under supervised by Nevy Diana Hanafi and Nini Rahmawati. The purpose of this study to determine dosage of fermented goat urine on number of tillers, plant height production of fresh dry matter, content of Phosphor and potassium on different forages (Pennisetum purpureum schumach), (Setaria sphacelata) and (Brachiaria brizantha). Experimental design used factorial with two factors, the first factor w...

  19. A Model for Understanding the Relationship Between Transaction Costs and Acquisition Cost Breaches

    Science.gov (United States)

    2014-04-30

    John Dillard, Chip Franck, and Francois Melese. 2007. Applying Insights from Transaction Cost Economics (TCE) to Improve DoD Cost Estimation. NPS...GSBPP-07-008. Monterey, CA: Naval Postgraduate School. Angelis, Diana, John Dillard, Chip Franck, and Francois Melese. 2008. Measuring Transaction...Jeffrey A. Drezner, James Dryden , Kenneth Horn, James G. Kallimani, Martin C. Libicki, Megan McKernan, Roger C. Molander, Charles Nemfakos, Chad J.R

  20. The Real Place of a Princess: Public Response

    Directory of Open Access Journals (Sweden)

    Lobna M. Shaddad

    2014-05-01

    Full Text Available The late Princess Diana of Wales (1961-1997 is one of the leading figures in the twentieth century. She used her fame as a British royal member to shed light on important humanitarian issues such as helping the homeless people, fighting against AIDS, donating money to cancer patients, supporting diseased children, and banning landmines. Her life has proven that she is one of the few celebrities who care for people; especially those in dire need. This is why she earned titles like ‘queen of people’s hearts’, ‘people’s princess’ and ‘England’s rose’. Diana’s death in a car accident has shocked the world and put it in great grief. The accident is considered by her public to be a terrible tragedy. This paper attempts to shed light on the emotional response that followed the princess’s death by studying twenty poems that were produced after her sudden death. Such poems reflect the huge influence that Princess Diana had and still has till this moment on the British way of life and thinking. The poems also assure that the real place of Diana is in her people’s hearts and memories. They also make it obvious that the sky is a better place for her; to be away from oppression and suffering. This paper will also apply the five stages of grief introduced by the psychiatrist Elisabeth Kübler-Ross to the poems in order to uncover the reasons behind giving Princess Diana such saint-like position by the public.

  1. La microbiota intestinal : un nuevo factor para prevenir la obesidad y la diabetes

    OpenAIRE

    Navarro del Cabo, Sonia

    2016-01-01

    RESUMEN: La obesidad y la diabetes mellitus tipo 2 son las nuevas epidemias del siglo XXI. Ambas son atribuidas a una combinación de la susceptibilidad genética y los factores relacionados con la vida diaria. El aumento de la prevalencia de dichas enfermedades, ha requerido nuevos estudios que identifiquen otros factores causales para así desarrollar tratamientos innovadores para frenar este crecimiento exponencial. Un novedoso agente ha emergido como posible diana terapéutica, la microbio...

  2. Pengolahan Jerami Jagung terhadap Kecernaan Pakan pada Ternak Sapi Peranakan Ongole

    OpenAIRE

    Halawa, Deonisus Erman

    2017-01-01

    DEONISUS ERMAN HALAWA, 2016 " Processing of straw corn for digestibility Cattle crossbread ongol Feed ". Supervised by NEVY DIANA HANAFI and ISKANDAR SEMBIRING. This research was conducted in the cage group Livestock Sari Tani, ,Secanggang village of North Sumatra Province in June - October 2016. Corn straw processing with methods of silage, ammoniation and fermentation by using starbio an effort to improve the quality of corn straw to be useful as animal feed. This study aimed to examine the...

  3. Urban Fragility and Security in Africa (Africa Security Brief, Number 12, April 2011)

    Science.gov (United States)

    2011-04-01

    relatively little in urban development, livelihoods, governance, or programs to help stem the volume of urban migra- tion. These changing demographics...such as narcot- ics trafficking in West Africa, political and eco- nomic cross-border migrants in Southern Africa, or climate change and resource... Environment and Development, 2004. 3 UN–HABITAT. 4 Diana Mitlin McGranahan et al., “Africa’s Urban Transi- tion and the Role of Regional Collaboration

  4. Psychopharmacology 2003 Conference, 10-13 September 2003

    OpenAIRE

    Diana P Morrison; Andre F Joubert; Dave Swingler; Denise White; Joseph R Calabrese; Roger M Pinder; Donald W Black; David R Williams; David Castle; Dora Wynchank; Kerry Gibson; Helen Clark; Greg McCarthy; Alan J Flisher; Sebastian Akalula

    2003-01-01

    List of abstracts and authors: 1. Comparative benefits of Atypical antipsychotics Diana P Morrison 2. Evidence-based management of depression in Schizophrenia Andre F Joubert 3. Second generation Antipsychotics: An African update Dave Swingler 4. The drug management of patients with HIV/Aids in the Mental Health Care setting: A therapeutic challenge Denise White 5. New developments in the treatment of Bipolar depression Jospeh R Calabrese 6. Dual a...

  5. Acquisition and Retention of a Letter-Detection Skill

    Science.gov (United States)

    1990-07-01

    third (final retention) tests. but the Aaverage of the first and third tesis did differ from that of the GL"’: A,= l, , sccord (initial rctcntion...414. fr’)ccSSC,d me Pd7J iuj.Ihhrd doctoral dLSutttior, in-~ Naylor, J. C.. & Brins. G. E. (1961). LonV-trM refgnFlILOt of icurned diana3 t:rivcr’sit

  6. Livres | Page 10 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    African Urban Harvest : Agriculture in the Cities of Cameroon, Kenya and Uganda. Au cours des deux dernières décennies, comment l'agriculture urbaine a-t-elle évolué dans les pays de l'Afrique subsaharienne ? Directeur(s) : Gordon Prain, Nancy Karanja, et Diana Lee-Smith. Maison(s) d'édition : Springer, CIP, CRDI.

  7. Armed Forces Institute of Regenerative Medicine

    Science.gov (United States)

    2009-01-01

    A. Balint , Asa Vaughan, PhD, (Rutgers – The State University of New Jersey) Therapy: Regeneration of fibrocartilaginous tissue such as the...Musculoskeletal Repair, AFIRM All Hands Conference, St. Petersburg, Florida, January 14-15, 2009 (abstract, poster and presentation). Balint EB, Gatt CJ...II-41, III-33 Angius, Diana II-36 Aurora, Amit II-27 B Badylak, Stephen F. II-9, II-64, II-67, II-69, II-70, II-71, II-72, II-73, VI-18 Balint

  8. Predicción del riesgo individual de alto coste sanitario para la identificación de pacientes crónicos complejos

    Directory of Open Access Journals (Sweden)

    Jordi Coderch

    2014-07-01

    Conclusiones: El consumo sanitario elevado se relaciona con la morbilidad crónica compleja. Un modelo basado en la edad, la morbilidad y la utilización previa es válido para predecir el riesgo de alto consumo, y así identificar la población diana de estrategias de atención proactiva para pacientes crónicos complejos.

  9. Truthfulness in science teachers’ corporeal performances

    DEFF Research Database (Denmark)

    Daugbjerg, Peer

    2014-01-01

    Relations between science teachers’ corporeal performances and their statements regarding these actions are discussed. Dispositions of truthfulness are applied to grasp the personal nuances in these relations. Three teachers’ corporeal performances and truthfulness are analysed. Diana shows effort......, sincerity and trustworthiness in dealing with classroom management. Jane shows effort, fidelity and honesty in developing outdoor teaching. Simon shows transparency, objectivity and sincerity in his support of colleagues. By addressing the relations in the vocabulary of truthfulness the teachers...

  10. Parenting Styles of Military and Civilian Families: The Impact of Deployment, Mood, and Marital Satisfaction

    Science.gov (United States)

    2012-09-12

    parenting styles may lead to better outcomes in children and adolescents ( Baumrind , 1991... parenting styles was greatly expanded in the late 1960s and early 1970s led by the work of Diana Baumrind . She believed that the key parental role was...syndrome, provided a label for Baumrind to apply to the controlling parent style that she identified ( Baumrind , 1989). In developing this parenting

  11. Noort moodi / Kätlin Karik

    Index Scriptorium Estoniae

    Karik, Kätlin

    2011-01-01

    ERKI Moeshow Volta tehases 4. juunil 2011. Loetletud lavale pääsenud kollektsioonid. Pikemalt kollektsioonidest "All that money" (Madis Luik, Karen Milistver, Nele Aunap), "Satellite orchids" (Olga Jazepova), "Vaktsiin" (Triinu Jõhve, Diana Tombak, Katrina Kaubi, Maarja Siim, Piret Mägi, Elina Peippo), "I love you...me neither" (Olga Rattik), "Haute sport couture" (Kristina Tatarinova). Kollektsioonide autorid vastavad kolmele küsimusele

  12. The life review and the (alternative) politics of ageing

    OpenAIRE

    Wilson, S.

    2017-01-01

    Referencing Diana Athill’s memoir, Alive, Alive Oh! And Other Things That Matter (2015), this article organises an analysis of the BBC television dramas A Cream Cracker under the Settee (1988) and She’s Been Away (1989) through the frame of Robert Butler’s concept of the life review (1975) which, he argues, is a process through which unresolved conflicts and past experiences return to reflective consciousness, thus enabling resolution and recalibration of relationships and past events in the ...

  13. Antichi dèi, oggi: la Ecate dei neo-pagani

    OpenAIRE

    Serafini, Nicola

    2014-01-01

    Hecate was an ambiguous deity in ancient Greece, who survived throughout late Antiquity and Early Medieval period without losing her terrifying and dark features. During the Early Modern era, assimilated to Diana and Herodias, she appears in demonologists’ treaties on witchcraft, being considered the patroness of witches. Nowadays, contemporary Neo-Paganism attaches a remarkable role to medieval folklore: thus, due to her special link to magic and witchcraft, the goddess Hecate is even now pa...

  14. Historic Royal events and the male to female ratio at birth in the United Kingdom.

    Science.gov (United States)

    Grech, Victor

    2015-08-01

    The male to female ratio of live births is expressed as the ratio of male live births divided by total live births (M/T). Factors which reduce M/T include toxins, stress and privation. Britain remains enamoured of the Monarchy. This study was carried out in order to ascertain whether Royal events influenced M/T in the UK. Live births were analysed in relation to the birth of Prince Charles (1948), the Coronation of Queen Elizabeth II (1952), the Silver Jubilee (1977), the wedding of Diana Spencer to Charles, Prince of Wales (July 1981), the birth of Prince William (1982), the death of Lady Diana (August 1997), the wedding of Kate Middleton to Prince William (2011) and the Golden Jubilee (2002). This study analysed 29,293,240 live births. There was a significant dip in M/T in the Coronation year (p=0.03). M/T dipped significantly in relation to the Royal Wedding, commencing a year before (p<0.0001). There were no significant M/T changes in relation to the Silver and Golden Jubilees. The birth of Prince William in 1982 resulted in a rise in M/T in the following year only (p=0.016). Analysis by quarter in relation to Lady Diana's death showed a decline in M/T 4-5 months later in the first quarter of 1998 (p=0.046). The anticipation and stress leading to the Coronation and Royal Wedding may have depressed M/T. Increased coital rates associated with exuberance in relation to Prince William's birth may have raised M/T. Lady Diana's death was temporally associated with a decline in M/T. Royalty events may affect M/T ratios in Britain. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  15. Spring Research Festival and NICBR Collaboration Winners Announced | Poster

    Science.gov (United States)

    By Carolynne Keenan, Contributing Writer, and Ashley DeVine, Staff Writer The winners of the 2014 Spring Research Festival (SRF), held May 7 and 8, were recognized on July 2, and included 20 NCI at Frederick researchers: Matthew Anderson, Victor Ayala, Matt Bess, Cristina Bergamaschi, Charlotte Choi, Rami Doueiri, Laura Guasch Pamies, Diana Haines, Saadia Iftikhar, Maria Kaltcheva, Wojciech Kasprzak, Balamurugan Kuppusamy, James Lautenberger, George Lountos, Megan Mounts, Uma Mudunuri, Martha Sklavos, Gloriana Shelton, Alex Sorum, and Shea Wright.

  16. Climate Change: Causes, Consequences, and How to Respond

    OpenAIRE

    Liverman, Diana; MacDonald, Glen

    2009-01-01

    Diana Liverman explores the theoretical positions for reducing greenhouse gas emissions including “earth-system management”, cap and trade policies, individual and community behavioral change, political economy of carbon governance (“carbon capitalism”), and government regulation and incentives. She supports a blending of the last three to produce “political ecology”. Liverman is critical of the Kyoto Accords but argues in favor of the Clean Development Mechanism [CDM] with some significant a...

  17. Defining the Role of Public Health in Disaster Recovery: An Evaluation of State Public Health Planning Efforts

    Science.gov (United States)

    2013-03-01

    National Weather Service, National Hurricane Center, 2011), 5– 7. 6 Robin Rudowitz, Diana Rowland, and Adele Shartzer, “Health Care in New Orleans...areas that are unique or novel and, therefore, bear further investigation and planning. The 15...provision of medical and behavioral health 36 services,”102 particularly due to the fact that this component bears reasonable similarity to the core

  18. ‘Bright Cynthia comes to hunt and revel here’ : constellations mythologiques et cynégétiques dans Titus Andronicus et Thomas of Woodstock ‘Bright Cynthia comes to hunt and revel here’: Mythological Clusters and the Motif of the Hunt in Titus Andronicus and Thomas of Woodstock

    Directory of Open Access Journals (Sweden)

    Agnès Lafont

    2009-06-01

    Full Text Available The various aspects of the myth of Diana the Huntress are normatively described by mythographers in their dictionaries or by emblematists; typically, she is the goddess of chastity as one can understand from the set phrase: “as chaste as Diana”. Once included in a dramatic text however, the myth of Diana can turn out to be only a mask under the cover of which bloody deeds may be perpetrated. Thus, in addition to appearing on stage as a revengeful huntress in the anonymous tragedy, The First Part of Richard II or Thomas of Woodstock, she also provides the perverted guise worn by the lascivious Tamora to seduce and kill her victims in Titus Andronicus. An analysis of the proper / improper reinterpretations of this classical myth within the performance text of these two tragedies allows us to draw a new portrait of the once virtuous and amiable deity that presided over amorous love sonnet sequences of the period – Delia by Samuel Daniel (1592 and Diana by Henry Constable (1594.

  19. Accurate microRNA target prediction correlates with protein repression levels

    Directory of Open Access Journals (Sweden)

    Simossis Victor A

    2009-09-01

    Full Text Available Abstract Background MicroRNAs are small endogenously expressed non-coding RNA molecules that regulate target gene expression through translation repression or messenger RNA degradation. MicroRNA regulation is performed through pairing of the microRNA to sites in the messenger RNA of protein coding genes. Since experimental identification of miRNA target genes poses difficulties, computational microRNA target prediction is one of the key means in deciphering the role of microRNAs in development and disease. Results DIANA-microT 3.0 is an algorithm for microRNA target prediction which is based on several parameters calculated individually for each microRNA and combines conserved and non-conserved microRNA recognition elements into a final prediction score, which correlates with protein production fold change. Specifically, for each predicted interaction the program reports a signal to noise ratio and a precision score which can be used as an indication of the false positive rate of the prediction. Conclusion Recently, several computational target prediction programs were benchmarked based on a set of microRNA target genes identified by the pSILAC method. In this assessment DIANA-microT 3.0 was found to achieve the highest precision among the most widely used microRNA target prediction programs reaching approximately 66%. The DIANA-microT 3.0 prediction results are available online in a user friendly web server at http://www.microrna.gr/microT

  20. Implementation of hybrid clustering based on partitioning around medoids algorithm and divisive analysis on human Papillomavirus DNA

    Science.gov (United States)

    Arimbi, Mentari Dian; Bustamam, Alhadi; Lestari, Dian

    2017-03-01

    Data clustering can be executed through partition or hierarchical method for many types of data including DNA sequences. Both clustering methods can be combined by processing partition algorithm in the first level and hierarchical in the second level, called hybrid clustering. In the partition phase some popular methods such as PAM, K-means, or Fuzzy c-means methods could be applied. In this study we selected partitioning around medoids (PAM) in our partition stage. Furthermore, following the partition algorithm, in hierarchical stage we applied divisive analysis algorithm (DIANA) in order to have more specific clusters and sub clusters structures. The number of main clusters is determined using Davies Bouldin Index (DBI) value. We choose the optimal number of clusters if the results minimize the DBI value. In this work, we conduct the clustering on 1252 HPV DNA sequences data from GenBank. The characteristic extraction is initially performed, followed by normalizing and genetic distance calculation using Euclidean distance. In our implementation, we used the hybrid PAM and DIANA using the R open source programming tool. In our results, we obtained 3 main clusters with average DBI value is 0.979, using PAM in the first stage. After executing DIANA in the second stage, we obtained 4 sub clusters for Cluster-1, 9 sub clusters for Cluster-2 and 2 sub clusters in Cluster-3, with the BDI value 0.972, 0.771, and 0.768 for each main cluster respectively. Since the second stage produce lower DBI value compare to the DBI value in the first stage, we conclude that this hybrid approach can improve the accuracy of our clustering results.

  1. Mosquitos (Diptera: Culicidae) de los parques naturales de la Comunidad Valenciana

    OpenAIRE

    Bernués Bañeres, Alberto

    2013-01-01

    La familia Culicidae incluye algunas de las especies de dípteros más relevantes en el ámbito de la Salud Pública, no solo por las molestias que son capaces de causar debido a su tipo de alimentación hematófaga, sino por su capacidad para actuar como vectores de enfermedades de afección humana. Por este motivo, los mosquitos han sido, desde siempre, una de las dianas predilectas en los programas de control establecidos para la regulación de sus poblaciones y, por tanto, como medida profiláctic...

  2. Análisis de la variabilidad tensional en el hipertenso medida por diferentes métodos y su relación con el daño orgánico.

    OpenAIRE

    Abellán Huerta, José

    2016-01-01

    Introducción. La variabilidad de la presión arterial se ha postulado como un potencial predictor de eventos cardiovasculares. Algunos estudios han señalado un poder predictor de ictus y mortalidad superior incluso a los niveles medios de presión arterial. Del mismo modo, se ha relacionado a la variabilidad tensional con la presencia de daño de órgano diana cardiaco, renal, cerebral y arterial. Hay multitud de métodos para estimarla, sin embargo, no está claro cuál es el de elección. Se tiende...

  3. Presión arterial central y daño orgánico

    OpenAIRE

    Pérez Lahiguera, Francisco José

    2015-01-01

    HIPÓTESIS: En pacientes hipertensos, sin antecedentes de enfermedad cardiovascular, y que no están recibiendo tratamiento farmacológico, la medición de la presión arterial central (PAC), estimada por tontería de aplanamiento, aporta beneficios en la estratificación del riesgo cardiovascular (RCV) por predecir mejor que la presión arterial clínica y ambulatoria la presencia de lesión de órgano diana (LOD). OBJETIVO GENERAL: Determinar la utilidad de la mediación de la PAC, comparándola con la...

  4. Analysis of Movie I Am Not Stupid 2: Parenting Style 分析《小孩不笨2》电影的父母教育法

    OpenAIRE

    Mariana Mariana

    2015-01-01

    This paper, through Singaporean movie I am not Stupid 2, analyzes the relation between parenting and children’s growth process and also the action of parents should do to offer children for having a good growth process. Research was done based on Baumrind theory about parenting analysis to what kind of parenting that the parents of the movie I am not Stupid 2 offer to their children. Research used literature study to summarize, arrange, and analyze of Diana Baumrind as basis of the research. ...

  5. Guía de apoyo del personal de enfermería durante el diagnóstico y seguimiento del paciente celíaco y su entorno

    OpenAIRE

    Tejo Hoyos, Natalia

    2015-01-01

    La enfermedad celíaca es la patología por sensibilidad alimentaria más frecuente en nuestro entorno. Se define como la intolerancia permanente a las proteínas del gluten, que da lugar a un cuadro que afecta a todo el organismo, aunque el principal órgano diana es el intestino delgado. En la actualidad, se ha observado un aumento del número de casos diagnosticados en la edad adulta. Por ello, se considera necesario diseñar un plan de actuación para el diagnóstico precoz y el seguimiento de ...

  6. Videoconferencing in a hospital school: removing barriers.

    Science.gov (United States)

    Hill, Steve; Hill, Ann; Hampton, Dave

    2004-06-01

    Videoconferencing has enhanced the learning experiences of children who, as a result of medical difficulties, have attended James Brindley School. The School is based in thirteen hospitals and specialist units across Birmingham, and provides educational opportunities for children from 3 to 19 years of age. At one of these sites, the Diana, Princess of Wales, Children's Hospital, the use of videoconferencing has been extremely effective in practice, and experiences suggest that it should be adopted as a fundamental tool by those who wish to develop and enhance the educational process in similar environments.

  7. Factores diagnósticos endoscópicos y pronósticos relacionados con el Helicobacter Pylori en la enfermedad injerto contra huésped tras el trasplante alogénico de células hematopoyéticas

    OpenAIRE

    Velasco Guardado, Antonio

    2016-01-01

    [ES] INTRODUCCIÓN: El trabajo consta de tres artículos originales relacionados por un lado con el diagnóstico endoscópico e histológico en la Enfermedad de Injerto contra Huésped (EICH) tras el trasplante alogénico de células hematopoyéticas (TACH) y por otro sobre el papel que juega la infección por Helicobacter pylori (HP) en dicha enfermedad. El tracto gastrointestinal es la principal diana de la Enfermedad de Injerto contra Huésped. Su diagnóstico se basa en los hallazgos endoscópicos e ...

  8. EDU-SOA: Un enfoque orientado a servicios para la Creación, gestión y enseñanza de cursos Web

    OpenAIRE

    Corbo Crespo, Amparo

    2013-01-01

    Proyecto Fin de Carrera leído en la Universidad Rey Juan Carlos en el curso académico 2012/2013. Tutor del Proyecto: Diana Pérez Marín La metodología orientada a servicios (SOA) supone muchos beneficios en campos, como en el financiero, ya que se elimina el uso de aplicaciones monolíticas que requieren operatividad en tiempo real. Esta metodología reduce dependencias y facilita las migraciones. También fomenta la reutilización de código y la eliminación de redundancias, facilit...

  9. Vías de señalización y potenciales agentes terapéuticos en un modelo in vitro de síndrome alcohólico fetal

    OpenAIRE

    Selva Sánchez, Javier

    2011-01-01

    [spa] El alcohol que consumimos (etanol) es un conocido teratógeno. En aquellas mujeres embarazadas es capaz de cruzar la barrera placentaria perturbando el desarrollo del feto. Los desordenes relacionados con el etanol (DRAF), son la tercera causa de retraso mental en el mundo, y entorno al 2% de los nacimientos en el mundo sufren DRAF. En esta tesis se describen dianas moleculares por las cuales la exposición a etanol puede estar alterando el desarrollo del Sistema Nervioso Central (SNC), e...

  10. Playing by the rules. The Hague courts and the Acteonisation du Grand Veneur d’Hollande (1643

    Directory of Open Access Journals (Sweden)

    Marika Keblusek

    2017-02-01

    Full Text Available This article discusses an unpublished play, Acteonisation du Grand Veneur d’Hollande (1643. Created – and possibly performed – within the immediate circle of the court of Elizabeth of Bohemia in The Hague, its anonymous author satirizes the various personalities in the Orange courts of respectively Frederik Hendrik and Amalia von Solms, and Willem II and Mary Stuart. Focusing on the social ambitions of Johannes Polyander van Kerckhoven, Lord of Heenvliet, and by using the popular myth of Actaeon and Diana, the clash between court and city, between princely aristocrats and republican burghers is played out.

  11. African Urban Harvest : Agriculture in the Cities of Cameroon, Kenya ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    1 janv. 2010 ... Professeure d'écologie des sols à l'Université de Nairobi, Nancy Karanja a été, de 2005 à 2009, coordonnatrice régionale d'Urban Harvest en Afrique ... Diana Lee-Smith a été coordonnatrice régionale d'Urban Harvest en Afrique de 2002 à 2005, période au cours de laquelle ont été menées à bien la ...

  12. El vermell és el color de l'agressivitat, diu un estudi

    OpenAIRE

    Bueno i Torrens, David, 1965-

    2017-01-01

    Els colors influeixen en la nostra percepció de la realitat. Molts animals els fan servir per comunicar-se entre ells de manera instintiva, tot sovint per establir les relacions de dominància. Diana Wiedemann i els seus col·laboradors, dels departaments d'antropologia i de psicologia de la Universitat de Durham, al Regne Unit, han analitzat l'efecte del color vermell sobre la percepció que tenim de les altres persones. Segons conclouen al seu treball, que han publicat a Biology Letters, dur r...

  13. Estudio proteómico y metabolómico de la enfermedad cardiovascular en la búsqueda de nuevos biomarcadores

    OpenAIRE

    Martín Lorenzo, Marta

    2016-01-01

    Las enfermedades cardiovasculares son las responsables del mayor número de muertes en el mundo siendo la aterosclerosis la causante de la mayoría de ellas. Dado su desarrollo durante décadas de manera silente y asintomática, la comunidad clínica está de acuerdo en que se necesitan con urgencia nuevos paneles de marcadores de riesgo así como la identificación de nuevas dianas moleculares terapéuticas. El mejor entendimiento de los mecanismos operantes es también de extrema necesidad para un me...

  14. Analysis of Movie I am not Stupid 2: Parenting Style

    OpenAIRE

    Mariana

    2015-01-01

    This paper, through Singaporean movie I am not Stupid 2, analyzes the relation between parenting and childrens growth process and also the action of parents should do to offer children for having a good growth process. Research was done based on Baumrind theory about parenting analysis to what kind of parenting that the parents of the movie I am not Stupid 2 offer to their children. Research used literature study to summarize, arrange, and analyze of Diana Baumrind as basis of the research. T...

  15. Browse Author Index

    African Journals Online (AJOL)

    Items 1 - 30 of 30 ... A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All. V. Van den Borne, Bart · Van den Borne, Hubertus W · Van der Brug, Mienke · Van der Heijden, Ingrid · van der Merwe, Anita · Van der Walt, Engela · Van Diepen, Irma · Van Dijk, Diana · van Dijk, Rijk · Van Driel, Francien · van Dyk, Alta C · Van Dyk ...

  16. Comparación de los efectos in vivo del D-003, una mezcla de ácidos de alto peso molecular obtenida de la cera de caña de azúcar y el extracto de uva sobre marcadores de peroxidación lipídica en ratas

    OpenAIRE

    Pérez, Yohani; Molina, Vivian; Más, Rosa; González, Rosa María; Jiménez, Sonia

    2008-01-01

    Los radicales libres producen efectos dañinos sobre las moléculas diana, como una incrementada peroxidación de lípidos (PL), proteínas y del ADN, lo cual puede ser inhibido o reducido por sustancias antioxidantes. El D-003 es una mezcla de ácidos de alto peso molecular obtenida de la cera de la caña de azúcar que ha mostrado inhibir la peroxidación lipídica en modelos animales y voluntarios sanos. El extracto de Uva, rico en flavonoides, ha demostrado poseer efectos antioxidantes efectivos y ...

  17. Inhibición de la ruta del TGFB por las hormonas tiroideas y sus efectos en fibrosis e inflamación

    OpenAIRE

    Alonso Merino, Elvira

    2017-01-01

    Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Bioquímica. Fecha de lectura: 13-01-2017 El factor de crecimiento transformante beta (TGFβ), el factor profibrogénico más importante, media sus acciones principalmente a través de los factores de transcripción Smads, los cuales se unen a los denominados Elementos de Unión a Smad (SBEs) en las regiones reguladoras de sus genes diana. En este trabajo demostramos que la hormona ti...

  18. Búsqueda computacional de pequeños fármacos contra la enfermedad de Huntington

    OpenAIRE

    Amaro Corbalán, Cristian

    2017-01-01

    La búsqueda y descubrimiento de nuevos fármacos se ha visto agilizada en los últimos años con el avance de la tecnología. La bioinformática se está abriendo paso en el mundo de la farmacéutica con técnicas como el virtual screening permitiendo realizar búsquedas de compuestos (ligandos) con afinidad a estructuras proteicas (diana) relacionado con alguna enfermedad. Este es el inicio del análisis realizado en este trabajo. Partiendo de la enfermedad de Huntington se ha seleccionado la Hu...

  19. Efectos de la insulina y el agua oxigenada sobre el metabolismo de los hidratos de carbono en adipocitos aislados de tejido adiposo de rata

    OpenAIRE

    Padial León, María José

    2011-01-01

    Se ha realizado un estudio comparativo de los efectos de la insulina y el h2o2 tanto en tejido adiposo de ratas normales como en tejido adiposo de ratas sometidas a un periodo prolongado de ayuno (situaci??n que hay que resaltar se manifiesta por una alteraci??n de la respuesta biol??gica a la insulina), en dicho estudio se incluye la observaci??n del efecto de la insulina y el per??xido de hidrogeno sobre la actividad de un enzima clave del metabolismo intermediario que sea diana de la activ...

  20. Derecho a la ciudad: derecho a negociar por unas condiciones materiales de vida

    OpenAIRE

    Yuri Romero Picu00F3n

    2003-01-01

    Este artículo se basa en una investigación etnográfica realizada en el barrio Diana Turbay en Bogotá. Su objetivo es analizar ciertos aspectos que favorecieron la conformación de este barrio de origen ilegal, la organización de sus habitantes en su lucha diaria por conseguir unas mejores condiciones de vida y la dinámica de cambio de sus relaciones sociales como parte del proceso de integración del barrio a la ciudad. Este artículo se inscribe en los debates sobre derecho a la ciudad y sobre ...

  1. Uus plaat

    Index Scriptorium Estoniae

    2004-01-01

    Uutest plaatidest Janet Jackson "Damita Jo", N.E.R.D. "Fly or Die", Oleg pissarenko Trio "The Little One's", "Dance Express", Neiokõsõ "Tii", Agnetha Fältskog "My Colouring Book", Diana Krall "The Girl In The Other Room", Hedvig Hanson & Andre Maaker "Nii õrn on öö", "D12 world", Blank&Jones "Monument", "Rock Ballads", "The Passion of The Christ", "Anastacia", "Kill Bill. Vol.2", Metro Luminal "Coca Cola, "No-Big-Silence & Kosmikud", Londonbeat "The very Best Of"

  2. Filling the Empty Space: Women and Latin American Theatre

    Directory of Open Access Journals (Sweden)

    Kirsten F. Nigro

    1996-01-01

    Full Text Available In recent years, Latin American women have begun to appropriate and fill a space once empty of their presence. This essay looks at the work of four such women, (Diana Raznovich and Cristina Escofet of Argentina, Raquel Araujo of Mexico and the Peruvian Sara Joffre, to see how they give substance and voice to their particular concerns. In the process, this essay focusses on: 1 the notion of gender as performance; 2 the feminist deconstruction of narrative; 3 the female body in theatrical space; and 4 new, postmodern ways of doing feminist political theatre.

  3. Nanosistemas avanzados para aplicaciones dermatológicas /

    OpenAIRE

    Miñana Prieto, Rafael,

    2017-01-01

    La llegada de la nanotecnología a las ciencias de la salud ha generado muchas expectativas debido a las importantes aplicaciones diagnósticas, terapéuticas y cosméticas. Uno de los grandes retos en este proceso reside en el desarrollo de «nanoterapias», dirigidas específicamente a los tejidos y órganos diana, evitando los efectos secundarios de los tratamientos actuales. Debido a su biocompatibilidad, las nanopartículas de oro (AuNPs) son unas de las nanopartículas metálicas más utilizadas en...

  4. Nanosistemas avanzados para aplicaciones dermatológicas

    OpenAIRE

    Miñana Prieto, Rafael

    2017-01-01

    La llegada de la nanotecnología a las ciencias de la salud ha generado muchas expectativas debido a las importantes aplicaciones diagnósticas, terapéuticas y cosméticas. Uno de los grandes retos en este proceso reside en el desarrollo de «nanoterapias», dirigidas específicamente a los tejidos y órganos diana, evitando los efectos secundarios de los tratamientos actuales. Debido a su biocompatibilidad, las nanopartículas de oro (AuNPs) son unas de las nanopartículas metálicas más utilizadas...

  5. Interaction of opioid and Notch signaling cascades. Implications in dopaminergic development after morphine administration

    OpenAIRE

    García Concejo, Adrián

    2017-01-01

    [ES]El análisis de la cascada de señalizacion molecular activada por la morfina puede permitir el descubrimiento de nuevas dianas terapéuticas que puedan ser usadas para paliar los efectos derivados del uso de opioides, Los receptores opioides han sido ampliamente estudiados, y su regulación después de su activación podría explicar las bases moleculares de la adicción. De entre todos los cambios ejercidos tras la administración de morfina, los cambios en los niveles de expresión de algunos mi...

  6. Entrada de calcio inducida por los oligómeros del péptido amiloide en la Enfermedad de Alzheimer

    OpenAIRE

    Caballero Ortega, Erica

    2013-01-01

    Los oligómeros del péptido amiloide (Aß1-42) se consideran como la neurotoxina presente en la enfermedad de Alzheimer. Nuestro grupo ha demostrado que los oligómeros, pero no las fibrillas, producen entrada de calcio en las neuronas y sobrecarga de calcio mitocondrial, lo cual lleva a la muerte celular. Sin embargo, la principal diana de los oligómeros es motivo de discusión. El objetivo es investigar las diferentes vías de entrada de calcio y el papel de la formación de conexiones sinápticas...

  7. Estudio microanatómico, de imagen y eléctrico de la unión diencéfalo-mesencefálica : aplicación a la cirugía de estimulación cerebral profunda en la enfermedad de Parkinson

    OpenAIRE

    González López, Pablo

    2013-01-01

    INTRODUCCION “Hyperactivity in the subthalamic nucleus (STN) projections to the globus pallidus medialis (GPM) has been stablished as a crucial feature of parkinsonism in animal models of Parkinson´s disease (PD)” Con esta afirmación, Guridi et al., dan luz verde en el año 1993 al estudio y desarrollo del Núcleo Subtalámico como una nueva diana terapéutica en la estimulación cerebral profunda para el tratamiento de la Enfermedad de Parkinson. El núcleo subtalámico se ha utilizado de...

  8. Propiedades neuroprotectoras de los esteroides sexuales

    OpenAIRE

    Veiga, Sergio; García-Segura, Luis M.; Azcoitia, I.

    2004-01-01

    [ES]El sistema nervioso es una diana de las hormonas esteroides y también un tejido esteroidogénico, y produce esteroides que actúan de una forma paracrina o autocrina sobre neuronas y glía. Los esteroides formados en el tejido nervioso se denominan neuroesteroides, para diferenciarlos, por su origen, de los esteroides periféricos, aunque tienen la misma estructura molecular que éstos. Desarrollo. Se analiza la capacidad de las neuronas y las células de glía de sintetizar esteroides, y se des...

  9. On the analysis of the stellar vault of Santa Maria del Monte in Cagliari

    Science.gov (United States)

    Grillanda, Nicola; Manconi, Fabio; Stochino, Flavio; Cazzani, Antonio; Bondi, Francesco; Chiozzi, Andrea; Tralli, Antonio

    2017-11-01

    The aim of this paper is to study the statics of the stellar (i.e. star-shaped) vault of the church of Santa Maria del Monte in Cagliari. This church, which was built during the second half of the 16th century, is a beautiful example of Gothic-Catalan style and the ribbed stellar vault is one of the most representative of this type in the town of Cagliari. A comparison between a static finite element non-linear analysis carried out with the commercial code Diana and a limit analysis performed with a method recently developed by the research team of the University of Ferrara is presented.

  10. Effects of oxidative stress on plasma membrane fluidity: biological consequences

    OpenAIRE

    de la Haba Fonteboa, Carlos

    2015-01-01

    El estrés oxidativo (OS) es característico de muchas enfermedades y se produce cuando hay un desequilibrio entre oxidantes y antioxidantes, lo cual favorece un estado oxidativo que genera especies reactivas de oxígeno y de nitrógeno. Los lípidos de la membrana plasmática son dianas preferentes del OS y ello tiene como consecuencia la peroxidación lipídica. Este proceso modifica propiedades de la membrana tales como su fluidez, característica física muy importante conocida por modular la local...

  11. Síntesis y caracterización de poliuretanos sensibles al medio para aplicaciones biomédicas

    OpenAIRE

    Pérez García, Francisco José

    2016-01-01

    La mayoría de los fármacos administrados por vía sistémica presentan baja biodisponibilidad, de manera que la concentración en plasma se encuentra por debajo de los niveles de efectividad. Actualmente, los sistemas de liberación controlada (SLC) permiten mejorar la biodisponibilidad de los fármacos previniendo la degradación, controlando la velocidad de liberación, disminuyendo los efectos secundarios y haciendo más eficaz su transporte hacia las dianas terapéuticas. Existe una amplia vari...

  12. Kazuistika pacienta s Guillain - Barré syndromem

    OpenAIRE

    Dvořáková, Diana

    2013-01-01

    Title of the thesis: Case report of a patient with a diagnosis of Guillain - Barré syndrome Author: Diana Dvořáková Aim of the work: The objective of the general work is to summarize knowledge about Guillain-Barre syndrome. The objective of special work is the case report processing .This part of the work decsribes possible rehabilitaion process and evaluates effect of the choosen therapeutic methods of the patient with this disease. Method of work: This thesis has been worked up on the basis...

  13. The gifts of silence and solitude.

    Science.gov (United States)

    Schmidt Bunkers, Sandra

    2008-01-01

    In this column the author describes the importance of finding silence and solitude amid the noise and technology present today in the teaching-learning academy. Three gifts of silence and solitude are identified: the gift of comforting aloneness, the gift of vision for new horizons, and the gift of a sense of freedom. A humanbecoming perspective is used to explore the implications of these gifts. This column introduces a column by Diana Vander Woude describing her teaching-learning experience in leadership focusing on silence and solitude.

  14. CLOC: Un sistema local de gestión interactiva de catálogos

    OpenAIRE

    López Blanco, Rafael

    2010-01-01

    Proyecto Fin de Carrera leído en la Universidad Rey Juan Carlos en el curso académico 2009/2010. Tutor del Proyecto: Diana Pérez Marín El motivo principal de la realización de este proyecto es desarrollar un sistema informático que proporcione la posibilidad de catalogar películas, CDs de música y libros con el ordenador a personas de cualquier edad, siempre y cuando tengan unos conocimientos mínimos de informática. En particular, es necesario que los usuarios sepan utilizar el ra...

  15. [Femicides: concepts, types and scenarios].

    Science.gov (United States)

    Meneghel, Stela Nazareth; Portella, Ana Paula

    2017-09-01

    This text is a theoretical essay that discusses the concepts, types and scenarios of feminicides, and presents some proposals for the prevention of these premature, unjust and avoidable deaths. The text revisits the original concept of femicide proposed by Diana Russell and Jane Caputti and shows new and old scenarios where these crimes occur. It points to patriarchy, understood as being a hierarchical system of power between men and women, as one of the main determinants of these deaths. It ends by presenting actions and proposals to prevent and combat these gender crimes.

  16. Combinación de diferentes estrategias de aplicación de hongos entomopatógenos para el control de Spodoptera littoralis (Boisduval) (Lepidoptera: Noctuidae) y Bemisia tabaci (Gennadius) (Hemiptera:Aleyrodidae)

    OpenAIRE

    Resquín Romero, Gloria Arminda

    2016-01-01

    Los ascomicetos mitospóricos entomopatógenos, que actúan por vía tegumentaria, han sido utilizados para el control microbiano de plagas mediante distintas estrategias que permiten el contacto de sus conidios con los insectos diana. Sin embargo, se conocen nuevos aspectos sobre su función ecológica tales como su capacidad secretora de compuestos con actividad insecticida, así como su sorprendente comportamiento como endófitos, que complementan su empleo clásico y que pueden pantag ermitir e...

  17. Genotipado de polimorfimos de un único nucleótido relacionados con el tratamiento con curmarinas de enfermedades cardiovasculares.

    OpenAIRE

    SANCHÓN SÁNCHEZ, PAULA

    2017-01-01

    [ES] El acenocumarol ((RS)-4-hidroxi-3-[1-(4-nitrofenil)-3-oxobutil]cromen-2-ona) es un anticoagulante de la familia de las cumarinas comercializado como Sintrom. Su mecanismo de acción se basa en actuar como antagonista de la vitamina K, siendo su diana la enzima VKORC1. Este fármaco se administra en numerosos pacientes con problemas cardiovasculares. Sin embargo, existe una amplia variabilidad interindividual en la respuesta, por lo que el ajuste de la dosis es crítico para e...

  18. ¿Más allá de la postmodernidad?: ‘Countdown’, Beyoncé y Keersmaeker

    OpenAIRE

    Sanjuán Astigarraga, José Ignacio

    2017-01-01

    La cantante americana Beyoncé utiliza en el videoclip de la canción Countdown elementos de dos coreografías de Anna Teresa De Keersmaeker. El presente texto intenta establecer qué elementos toma Beyoncé de las obras de Keersmaeker y cómo se relaciona esta apropiación con otras imágenes (Audrey Hepburn, Diana Ross) que también aparecen en el vídeo American singer Beyoncé used in the music video for the song Countdown elements of two choreographies by Anna Teresa De Keersmaeke...

  19. Estilos de crianza en familias nucleares con hijos únicos

    OpenAIRE

    Quezada Fernández, Juan Carlos

    2015-01-01

    La Teoría clásica de Diana Baumrind plantea tres estilos de educación familiar, a partir de ella se pretende conocer los estilos educativos de las familias nucleares con un solo hijo, y relacionar estos estilos de crianza con la estructura familiar: jerarquía límites y alianzas. El estudio fue cuantitativo y cualitativo, las variables dependientes fueron los estilos de educación familiar, las variables independientes la estructura familiar. La selección de la muestra se realizó desde la ...

  20. Discurso da Profa. Maria Isabel Rodríguez, por ocasião da outorga do título de Doutora Honoris Causa da Universidade de Brasília.

    Directory of Open Access Journals (Sweden)

    Maria Isabel RODRÍGUEZ

    2015-08-01

    Full Text Available Presidente del Consejo Universitario y Magnifico Rector de la Universidad de Brasília, Profesor Ivan Marques de Toledo Camargo; Director de la Facultad de Medicina de la Universidad de Brasília, Profesor Paulo César de Jesus; Directora de la Facultad de Ciencias de la Salud de la Universidad de Brasília, MariaFátima Sousa; Directora de la Facultad de Ceilândia de la Universidad de Brasília, Diana LúciaMouraPinho; Dr. Danilo Aquino Amorim, Representante estudiantil.

  1. Autoevaluación: Fisiopatología del sistema endocrino

    OpenAIRE

    Hidalgo Blanco, Miguel Ángel; Andreu Periz, Lola

    2012-01-01

    El sistema endocrino es un sistema indispensable para mantener el desarrollo, el crecimiento, la reproducción, el metabolismo y la homeostasis del organismo. Está constituido por células que liberan al torrente sanguíneo unas sustancias denominadas hormonas que actúan como «mensajeros químicos», de forma similar a los impulsos eléctricos que utiliza el sistema nervioso; producen efectos únicamente en las células diana, que son las que disponen de receptores específicos para dichas hormonas. É...

  2. Cognición y síntomas negativos en la esquizofrenia

    OpenAIRE

    Bagney Lifante, Alexandra

    2016-01-01

    Aunque los delirios y alucinaciones, también denominados síntomas positivos, se han considerado como los más característicos de la esquizofrenia y tradicionalmente han supuesto la diana de los tratamientos para el trastorno, hoy en día se conoce que no son éstos los síntomas más ligados al pronóstico y funcionalidad de los pacientes. En los últimos años se ha puesto de manifiesto que los denominados síntomas negativos (que incluyen aspectos como la abulia, la asociabilidad, la anhedonia, la a...

  3. Evaluación de la biodistribución en ratas de una cumarina libre y microencapsulada

    OpenAIRE

    Hernández Camargo, Aura Rocío

    2013-01-01

    Los estudios de biodistribución desarrollados hasta ahora en diferentes lugares y grupos de investigación a nivel mundial, se han efectuado con el fin de encontrar herramientas principalmente en tecnología farmacéutica, que permitan el direccionamiento de fármacos a sitios especiales; en su mayoría a órganos diana de difícil acceso o incluso para el tratamiento de algunos tumores localizados. Particularmente, en el Departamento de Farmacia de la Universidad Nacional de Colombia no se han real...

  4. A computer graphics based model for scattering from objects of arbitrary shapes in the optical region

    Science.gov (United States)

    Goel, Narendra S.; Rozehnal, Ivan; Thompson, Richard L.

    1991-01-01

    A computer-graphics-based model, named DIANA, is presented for generation of objects of arbitrary shape and for calculating bidirectional reflectances and scattering from them, in the visible and infrared region. The computer generation is based on a modified Lindenmayer system approach which makes it possible to generate objects of arbitrary shapes and to simulate their growth, dynamics, and movement. Rendering techniques are used to display an object on a computer screen with appropriate shading and shadowing and to calculate the scattering and reflectance from the object. The technique is illustrated with scattering from canopies of simulated corn plants.

  5. Contribuição aos Hemilophini (Cerambycidae, Lamiinae da Colômbia e do Equador Contribution to the Hemilophini (Cerambycidae, Lamiinae of Colombia and Ecuador

    Directory of Open Access Journals (Sweden)

    Ubirajara R. Martins

    2004-03-01

    Full Text Available New taxa described: from Ecuador, Quirimbaua gen. nov., type species Q. castroi (Napo; from Colombia: Icupima taua (Cauca, Adesmus murutinga and Tyrinthia dioneae (Valle del Cauca, Essosthrutella acatinga and Hemilomecopterus gen. nov., type species, H. alienus (Amazonas. New records for Colombia are presented for Olivensa mimula Lane, 1965, Tyrinthia paraba Martins & Galileo, 1991, Amapanesia exotica (Martins & Galileo, 1991, Sibapipunga beckeri (Martins & Galileo, 1992, Juninia annulifera (Kirsch, 1889, Isomerida albicollis (Laporte, 1840, Adesmus diana (Thomson, 1860, A. pirauna Galileo & Martins, 1999, Phoebe concinna White, 1856 and Leucophoebe albaria (Bates, 1872. A key to the species of Essosthrutella is added.

  6. The FARC a way into new wars

    Directory of Open Access Journals (Sweden)

    José Fernando Valencia Grajales

    2011-07-01

    Full Text Available This text, first comparing the FARC with the texts of Mao Tse-Tung, Strategic Issues in Guerrilla War Against Japan, with Diana Hernández Hoyos, International Humanitarian Law: How and why to apply international humanitarian law to the law and the internal conflict in Colombia, also Mary Kaldor, New Wars, Chapter 2 and 3, with Peter Waldman and Fernando Reinares, in companies in the Civil War, Chapter 1 and 3, and also that of Eduardo Pizarro Leon Gomez. The FARC, Defense to the Combination of All Forms of Struggle. Chapter 1, second in the comparisons were attempted an analysis of the historical circumstances, to finely make conclusions

  7. Receptores de insulina en hematíes: caracterización del sistema. Estudios en pacientes obesos y con infarto de miocardio

    OpenAIRE

    Griera Borras, José Luis

    1982-01-01

    Tras la publicación a finales de 1978 por GAMBHIR y Cols. de la existencia de receptores de insulina en hematíes, iniciamos este trabajo con la idea de utilizar este tipo de célula para el estudio de la interacción insulina-receptor, ya que ofrecía “a priori” una serie de ventajas sobre los tejidos diana “clásicos” (músculo, hígado, tejido graso) y otros de más reciente adquisición (v.g. monocitos ...

  8. Science.gov (United States)

    PASSALI, D.; BENEDETTO, F.; BENEDETTO, M.; CHIARAVALLOTI, F.; DAMIANI, V.; PASSALI, F.M.; BELLUSSI, L.M.; THE WORKING GROUP

    2011-01-01

    SUMMARY In spite of the amount of literature demonstrating the relationship between upper and lower airways, both from the anatomical, and pathophysiological point of view, little is known about the epidemiology, diagnosis and treatment of the Rhino-Bronchial Syndrome (RBS). After the publication, in 2003, of a Consensus Report defining the Rhino-Bronchial Syndrome, an interdisciplinary group of experts made up from the Italian ENT Society (SIO) and the Interdisciplinary Scientific Association for the Study of Respiratory Diseases (AIMAR) met again in 2005 in order to study a protocol which would have, as the main tasks, the analysis of RBS signs and symptoms and standardization of the diagnostic approach. A secondary endpoint was to characterize the most effective therapeutic options and to correct the great dyshomogeneity in the therapeutic approaches. With this aim, 9 ENT and Pneumology Centres were selected, based on the ability to multidisciplinary cooperation, availability of useful instrumentation and homogeneous distribution over the entire National territory. Overall, 159 patients were enrolled according to clinical history (major and minor symptoms of upper and lower airways) and inclusion/exclusion criteria. All underwent a two level diagnostic approach. In 116 patients, the diagnosis was confirmed on the basis of I level (rhinopharyngeal endoscopy and basal spirometry, respectively, for upper and lower airways) examination. Allergic and infectious diseases were significantly more frequent (37.9% vs 20.9% and 73.3% vs 46.55, respectively) in patients with a confirmed diagnosis for Rhino-Bronchial Syndrome. Nasal obstruction (93%), rhinorrhoea (75%), cough (96%) and dyspnoea (69%) were the more frequent symptoms. The presence of meatal secretions or polyps were the clinical findings significantly differing at endoscopy in the two groups. After 3 months of treatment, according to "good clinical practice" (inhaled steroids, antibiotics, nasal lavages), 96

  9. Caracterización de la población geriátrica hipertensa de un consultorio médico de la familia

    Directory of Open Access Journals (Sweden)

    Rafaela Yamilet Lora Martínez

    2015-02-01

    Full Text Available En los últimos años se ha incrementado la aparición de la hipertensión arterial en el adulto mayor, por lo que se realiza una investigación descriptiva transversal, para caracterizar clínica y epidemiológicamente esta entidad en los adultos mayores, atendidos en el consultorio médico de la familia (CMF No 8, perteneciente al Policlínico “Romárico Oro” de Puerto Padre, en el año 2012. La población de estudio estuvo constituida por todos los gerontes dispensarizados como hipertensos. Se analizaron las variables: factores de riesgo asociados, manifestaciones clínicas, hallazgos en exámenes complementarios y electrocardiográficos y daño en órganos diana. Dentro de los factores de riesgo asociados predominaron los antecedentes familiares de hipertensión arterial, sedentarismo y estrés. La manifestación clínica más abundante fue la cefalea. El hallazgo en exámenes complementarios y electrocardiográficos más frecuente fue la hipertrofia ventricular izquierda, siendo el corazón el órgano diana más afectado

  10. Sobre la enunciación poética y el doble: una aproximación a la poesía de Alejandra Pizarnik

    Directory of Open Access Journals (Sweden)

    Matilde Belén Escobar Negri

    2015-01-01

    Full Text Available Este trabajo se presenta como una aproximación a las problemáticas que surgen a partir de considerar la ficcionalidad literaria como una alternativa a la cuestión de la enunciación poética. Para tal fin, se parte de la idea de que la figura del doble podría ser pensada como una posibilidad enunciativa en la que convergen cuestiones propias de la ficción narrativa y nociones de las poéticas contemporáneas. En este análisis se tienen en cuenta las propuestas teóricas sobre la enunciación de Émile Benveniste y de Paul Ricoeur, y algunas ampliaciones del caso, conectadas con la idea de ficcionalidad poética que señalan autores como Diana Alejandra Espinoza Elías y Fernando Cabo Aseguinolaza. A partir de ellas se considera que es posible configurar un acercamiento a posiciones que vinculan las problemáticas del yo enunciativo de la poesía con propuestas acerca del doble en la literatura. Estas propuestas teóricas se utilizan para abordar algunos poemas de Árbol de Diana de Alejandra Pizarnik para observar allí cómo se visualizan dichos planteos.

  11. The Mythology of the Night Sky An Amateur Astronomer's Guide to the Ancient Greek and Roman Legends

    CERN Document Server

    Falkner, David E

    2011-01-01

    Every amateur astronomer can easily recognize most of the constellations, but how many of us know the story behind them? What myths did the Ancient Greeks weave around the mighty hunter Orion that places him so prominently in the sky? Did you know that this mythical being was said to have been killed by Diana, herself a hunter, while he was exhausted by his fight with Scorpius? The constellation of Scorpius, the giant scorpion, is dominated by the red supergiant Antares and hangs in the sky opposite Orion. Yet there is no constellation of Diana to be found! The Mythology of the Night Sky strikes a balance between backyard astronomy and ancient mythology. Organized by seasons, this book describes Ptolemy's 48 constellations with location and description in detail, while also telling the mythological tales in full. Along with the named constellations, this title also incorporates the lore behind the christening of the planets and their satellites. Readers discover the importance of the ancient characters, why...

  12. “Lasso of Truth”: Rediscovering the Forgotten History of Wonder Woman

    Directory of Open Access Journals (Sweden)

    Irena Jurković

    2015-06-01

    Full Text Available In a period witnessing the increasing popularity of superhero franchises, comic book historian Tim Hanley sheds light on the forgotten history of the world’s most famous female superhero, Wonder Woman. Tim Hanley’s Wonder Woman Unbound: The Curious History of the World’s Most Famous Heroine, as its title suggests, aims to explore the curious path of Wonder Woman: from the creation of the character to her contemporary iconic status. The book is comprised of three sections that follow the eras of American comic books: Golden Age, Silver Age and Bronze Age. Hanley starts off with Wonder Woman’s origin story, associating it primarily with the life and work of her creator, psychologist William Marston. The story begins when an American pilot, Steve Trevor, crashes on the hidden Paradise Island and is found injured by Diana and her fellow Amazons. Paradise Island is the home of mythical Amazons guided by goddesses Aphrodite and Athena. Their world is an only-female utopia situated far away from the outside, violent, world of men. However, while Amazons live in peace, the outside world is bursting with war and Steve needs to return to America to fulfill his soldier duties. The Amazon goddesses decide to send a warrior, Diana, to help Steve through his journey. That warrior later becomes a superheroine known by the name of Wonder Woman.

  13. Diversity and prevalence of gastrointestinal parasites in seven non-human primates of the Taï National Park, Côte d’Ivoire

    Science.gov (United States)

    Kouassi, Roland Yao Wa; McGraw, Scott William; Yao, Patrick Kouassi; Abou-Bacar, Ahmed; Brunet, Julie; Pesson, Bernard; Bonfoh, Bassirou; N’goran, Eliezer Kouakou; Candolfi, Ermanno

    2015-01-01

    Parasites and infectious diseases are well-known threats to primate populations. The main objective of this study was to provide baseline data on fecal parasites in the cercopithecid monkeys inhabiting Côte d’Ivoire’s Taï National Park. Seven of eight cercopithecid species present in the park were sampled: Cercopithecus diana, Cercopithecus campbelli, Cercopithecus petaurista, Procolobus badius, Procolobus verus, Colobus polykomos, and Cercocebus atys. We collected 3142 monkey stool samples between November 2009 and December 2010. Stool samples were processed by direct wet mount examination, formalin-ethyl acetate concentration, and MIF (merthiolate, iodine, formalin) concentration methods. Slides were examined under microscope and parasite identification was based on the morphology of cysts, eggs, and adult worms. A total of 23 species of parasites was recovered including 9 protozoa (Entamoeba coli, Entamoeba histolytica/dispar, Entamoeba hartmanni, Endolimax nana, Iodamoeba butschlii, Chilomastix mesnili, Giardia sp., Balantidium coli, and Blastocystis sp.), 13 nematodes (Oesophagostomum sp., Ancylostoma sp., Anatrichosoma sp., Capillariidae Gen. sp. 1, Capillariidae Gen. sp. 2, Chitwoodspirura sp., Subulura sp., spirurids [cf Protospirura muricola], Ternidens sp., Strongyloides sp., Trichostrongylus sp., and Trichuris sp.), and 1 trematode (Dicrocoelium sp.). Diversity indices and parasite richness were high for all monkey taxa, but C. diana, C. petaurista, C. atys, and C. campbelli exhibited a greater diversity of parasite species and a more equitable distribution. The parasitological data reported are the first available for these cercopithecid species within Taï National Park. PMID:25619957

  14. Diversity and prevalence of gastrointestinal parasites in seven non-human primates of the Taï National Park, Côte d'Ivoire.

    Science.gov (United States)

    Kouassi, Roland Yao Wa; McGraw, Scott William; Yao, Patrick Kouassi; Abou-Bacar, Ahmed; Brunet, Julie; Pesson, Bernard; Bonfoh, Bassirou; N'goran, Eliezer Kouakou; Candolfi, Ermanno

    2015-01-01

    Parasites and infectious diseases are well-known threats to primate populations. The main objective of this study was to provide baseline data on fecal parasites in the cercopithecid monkeys inhabiting Côte d'Ivoire's Taï National Park. Seven of eight cercopithecid species present in the park were sampled: Cercopithecus diana, Cercopithecus campbelli, Cercopithecus petaurista, Procolobus badius, Procolobus verus, Colobus polykomos, and Cercocebus atys. We collected 3142 monkey stool samples between November 2009 and December 2010. Stool samples were processed by direct wet mount examination, formalin-ethyl acetate concentration, and MIF (merthiolate, iodine, formalin) concentration methods. Slides were examined under microscope and parasite identification was based on the morphology of cysts, eggs, and adult worms. A total of 23 species of parasites was recovered including 9 protozoa (Entamoeba coli, Entamoeba histolytica/dispar, Entamoeba hartmanni, Endolimax nana, Iodamoeba butschlii, Chilomastix mesnili, Giardia sp., Balantidium coli, and Blastocystis sp.), 13 nematodes (Oesophagostomum sp., Ancylostoma sp., Anatrichosoma sp., Capillariidae Gen. sp. 1, Capillariidae Gen. sp. 2, Chitwoodspirura sp., Subulura sp., spirurids [cf Protospirura muricola], Ternidens sp., Strongyloides sp., Trichostrongylus sp., and Trichuris sp.), and 1 trematode (Dicrocoelium sp.). Diversity indices and parasite richness were high for all monkey taxa, but C. diana, C. petaurista, C. atys, and C. campbelli exhibited a greater diversity of parasite species and a more equitable distribution. The parasitological data reported are the first available for these cercopithecid species within Taï National Park. © R.W.Y. Kouassi et al., published by EDP Sciences, 2015.

  15. Glioblastoma: Análisis molecular y sus implicancias clínicas

    Directory of Open Access Journals (Sweden)

    Carlos A Castañeda

    Full Text Available El glioblastoma multiforme (GB es el tumor cerebral primario del sistema nervioso central (SNC más frecuente y más letal en la edad adulta. La evidencia epidemiológica indica que su incidencia es menor en la raza hispana. El tratamiento quirúrgico es la opción terapéutica preferente. Recientemente se han introducido nuevas estrategias que incrementan el volumen de resección. El uso de quimioterapia y radioterapia concurrentes mejora la supervivencia de los pacientes, aunque se asocia a toxicidad. La mejora en la comprensión de la biología molecular del GB ha permitido la identificación de biomarcadores predictivos de respuesta terapéutica y pronóstico, así como la identificación de dianas terapéuticas que han permitido el desarrollo de nuevas estrategias en el tratamiento de estos tumores. Entre los biomarcadores actualmente disponibles se encuentran la codelección 1p/19q, la mutación de IDH y la metilación del promotor O6- metilguanina DNA-metiltransferasa. La identificación de dianas terapéuticas permite el desarrollo de nuevas drogas y su evaluación posterior en ensayos clínicos, aunque ninguna de ellas ha sido validada prospectivamente en ensayos clínicos de fase III

  16. Bioinformatics analysis for evaluation of the diagnostic potentialities of miR-19b, -125b and -205 as liquid biopsy markers of prostate cancer

    Science.gov (United States)

    Bryzgunova, O. E.; Lekchnov, E. A.; Zaripov, M. M.; Yurchenko, Yu. B.; Yarmoschuk, S. V.; Pashkovskaya, O. A.; Rykova, E. Yu.; Zheravin, A. A.; Laktionov, P. P.

    2017-09-01

    Presence of tumor-derived cell-free miRNA in biological fluids as well as simplicity and robustness of cell-free miRNA quantification makes them suitable markers for cancer diagnostics. Based on previously published data demonstrating diagnostic potentialities of miR-205 in blood and miR-19b as well as miR-125b in urine of prostate cancer patients, bioinformatics analysis was carried out to follow their involvement in prostate cancer development and select additional miRNA-markers for prostate cancer diagnostics. Studied miRNAs are involved in different signaling pathways and regulate a number of genes involved in cancer development. Five of their targets (CCND1, BRAF, CCNE1, CCNE2, RAF1), according to the STRING database, act as part of the same signaling pathway. RAF1 is regulated by miR-19b and miR-125b, and it was shown to be involved in prostate cancer development by DIANA and STRING databases. Thus, other microRNAs regulating RAF1 expression such as miR-16, -195, -497, and -7 (suggested by DIANA, TargetScan, MiRTarBase and miRDB databases) can potentially be regarded as prostate cancer markers.

  17. Modelos de fissuração distribuída em vigas de concreto armado pelo método dos elementos finitos

    Directory of Open Access Journals (Sweden)

    R.C.G. Menin

    Full Text Available O objetivo principal do trabalho é apresentar uma comparação entre distintas estratégias de simulação computacional de estruturas de concreto armado utilizando modelos de fissuração distribuída. Em uma primeira abordagem, foi adotado o modelo multidirecional de fissuração distribuída do programa DIANA empregando-se diferentes regras de amolecimento para o material fissurado (frágil, linear e não-lineares de Moelands-Reinhardt e de Hordijk. Posteriormente, foi utilizada a formulação DSFM - Disturbed Stress Field Model, modelando o concreto fissurado como um material ortotrópico com fissuras distribuídas do tipo rotacionais. Os programas DIANA e VecTor2 foram utilizados como ferramentas para avaliar a eficácia dos diferentes modelos no estudo de vigas de concreto armado submetidas a esforços de flexão.

  18. Diversity and prevalence of gastrointestinal parasites in seven non-human primates of the Taï National Park, Côte d’Ivoire

    Directory of Open Access Journals (Sweden)

    Kouassi Roland Yao Wa

    2015-01-01

    Full Text Available Parasites and infectious diseases are well-known threats to primate populations. The main objective of this study was to provide baseline data on fecal parasites in the cercopithecid monkeys inhabiting Côte d’Ivoire’s Taï National Park. Seven of eight cercopithecid species present in the park were sampled: Cercopithecus diana, Cercopithecus campbelli, Cercopithecus petaurista, Procolobus badius, Procolobus verus, Colobus polykomos, and Cercocebus atys. We collected 3142 monkey stool samples between November 2009 and December 2010. Stool samples were processed by direct wet mount examination, formalin-ethyl acetate concentration, and MIF (merthiolate, iodine, formalin concentration methods. Slides were examined under microscope and parasite identification was based on the morphology of cysts, eggs, and adult worms. A total of 23 species of parasites was recovered including 9 protozoa (Entamoeba coli, Entamoeba histolytica/dispar, Entamoeba hartmanni, Endolimax nana, Iodamoeba butschlii, Chilomastix mesnili, Giardia sp., Balantidium coli, and Blastocystis sp., 13 nematodes (Oesophagostomum sp., Ancylostoma sp., Anatrichosoma sp., Capillariidae Gen. sp. 1, Capillariidae Gen. sp. 2, Chitwoodspirura sp., Subulura sp., spirurids [cf Protospirura muricola], Ternidens sp., Strongyloides sp., Trichostrongylus sp., and Trichuris sp., and 1 trematode (Dicrocoelium sp.. Diversity indices and parasite richness were high for all monkey taxa, but C. diana, C. petaurista, C. atys, and C. campbelli exhibited a greater diversity of parasite species and a more equitable distribution. The parasitological data reported are the first available for these cercopithecid species within Taï National Park.

  19. Collaboration on SEP Missions to the Moon and Small Bodies

    Science.gov (United States)

    Pieters, C. M.

    1997-01-01

    In response to the Discovery announcement of opportunity a team consisting of TRW Lewis Research Center, JPL and UCLA with scientific co-investigators from government and University laboratories have proposed to fly the first planetary solar electric propulsion (SEP) mission. Diana is designed to carry an X-ray and gamma ray spectrometer, and imaging spectrometer, a framing camera, a laser altimer an ion spectrometer and a magnetometer. In order to obtain lunar gravity data from the far side of the moon a relay satellite is placed into high polar orbit about the moon to relay the Doppler-shifted telemetry to Earth. Diana will spend two months in a 700 km polar orbit obtaining mineralogical data from a full spectral map of the lunar surface, and then spend a year in a 100 km (or below) polar orbit mapping the lunar elemental composition, its topography, gravity field, ions from its atmosphere and its permanent and induced magnetic fields. After the low altitude mapping phase the ion thrusters propel the spacecraft out of the lunar sphere of influence and onto a heloioscentric trajectory to rendezvous with dormant comet Wilson-Harrington. The ground truth provided by the returned lunar samples to validate the remote sensing instruments for lunar studies will also serve to validate the Wilson-Harrington observations since the same instruments will be used at both bodies.

  20. Elva, Viljandi,Tallinna ja Kuremäe võistlused / Karin Bachmann, Peeter Pere, Endrik Mänd, Veljo Kaasik

    Index Scriptorium Estoniae

    2016-01-01

    Eesti Vabariik 100 võistlussarja raames korraldatud arhitektuurivõistlustest Elvas, Viljandis, Tallinnas ja Kuremäel. Elva linn valis võistlusobjektiks kaubanduskeskuse ja parkla laienduse. Esimese preemia sai võistlustöö "Sõstrapõõsaste vahel" (autorid: Ülle Maiste, Diana Taalfeld, Anne Saarniit, Roomet Helbre ja Taavi Kuningas). Viljandi linna võistluse eesmärk oli leida terviklik ruumiline lahendus Vabaduse platsi ja selle lähialade ning Tallinna, Vaksali ja Vana-Vaksali tänava arenduseks. Esimese preemia sai võistlustöö "Tasa sõuab" (autorid: Ülle Maiste, Diana Taalfeld, Anne Saarniit, Roomet Helbre, Taavi Kuningas ja Mihkel Urmet). Tallinna linn valis võistlusobjektiks peatänava. Esimese preemia sai võistlustöö "Kevad linnas" (autorid: Toomas Paaver, Indrek Kustavus, Indrek Peil, Siiri Vallner, Kristel Niisuke, Valdis Linde ja Riin-Kärt Ranne). Kuremäe küla valis võistlusobjektiks küla keskuse kujundamise koos uute funktsioonide lisamisega. Esimese preemia sai võistlustöö "Rännak" (autorid: Helen Rebane, Kaie Kuldkepp ja Pelle-Sten Viiburg)

  1. Método Avenzoar para la implantación racional de la atención farmacéutica en la farmacia comunitaria

    Directory of Open Access Journals (Sweden)

    Ojeda-Casares M

    2015-06-01

    Full Text Available Introducción: La evolución de la atención farmacéutica en España, el desarrollo de las tecnologías de la información y la comunicación, los proyectos de receta electrónica, la aparición de publicaciones como el Foro de Atención Farmacéutica, el desarrollo del Bot Plus y su integración con los programas de gestión de las farmacias comunitarias nos han permitido definir una metodología de trabajo en atención farmacéutica (AF, estratificada y selectiva. Metodología: 1. Identificar el paciente destinatario del tratamiento. 2. Dispensación propiamente dicha. 3. Definición del perfil farmacoterapéutico de la farmacia. 3.1. Grupos terapéuticos. 3.2. Indicaciones terapéuticas. 4. Definición de patologías diana. 4.1. Relevancia numérica. 4.2. Relevancia terapéutica. 5. Definición del potencial de seguimiento farmacoterapéutico (SFT de la farmacia comunitaria. 6. Elección de pacientes diana. 7. Ofrecimiento del servicio de SFT. Resultados: En las cuatro farmacias comunitarias (FC participantes se definió el perfil farmacoterapéutico a partir de los grupos terapéuticos a nivel 1. A partir de aquí dichas farmacias definieron sus respectivas patologías diana y los posibles pacientes a los que ofrecer el servicio. Se basan en dichos resultados para establecer la formación de sus profesionales. Conclusiones: La metodología Avenzoar parte del conocimiento del paciente mediante el registro sistemático de las dispensaciones realizadas. Permite definir el perfil farmacoterapéutico de los pacientes. Permite decidir el nivel de implicación con el seguimiento de cada paciente según criterios previamente definidos. La metodología Avenzoar es compatible y complementaria con cualquier metodología de seguimiento farmacoterapéutico.

  2. Um atlas contra o vento

    Directory of Open Access Journals (Sweden)

    Raúl Antelo

    2011-06-01

    Full Text Available Este artigo aborda duas exposições, Atlas. Como llevar el mundo a cuestas?, cujo curador foi Georges Didi-Huberman e Imágenes e Historias. Argentina 1848-2010, curada por Diana Wechsler. Am-bas consideram a produção artística como fruto de montagem, em que objetos, espaços e tempos podem ser reconfigurados. Am-bas também encaram a experiência da imagem com base não na ordem cronológica e logocêntrica, como no historicismo clássico, mas a partir do reconhecimento da densidade de sentidos da imagem, bem como de seu poder expressivo, capaz de desestabilizar paradigmas epistemológicos da história da arte.Esta comunicación aborda dos exposiciones, Atlas. Como llevar el mundo a cuestas?, cuyo comisario fue Georges Didi-Huberman e Imágenes e Historias. Argentina 1848-2010, curada por Diana Wechsler. Ambas consideran la producción artística como fruto de montaje, en que objetos, espacios y tiempos pueden ser reconfigurados. Ambas encaran la experiencia de la imagen no en base al orden cronológico y logocéntrico, como en el historicismo clásico, sino basándose en el reconocimiento de la densidad de sentidos de la imagen y asimismo en su poder expresivo, capaz de desestabilizar paradigmas epistemológicos de la historia del arte.This paper focuses two exhibitions, Atlas. How to carry the world on one's back?, curated by Georges Didi-Huberman and Images and histories. Argentina 1848-2010, curated by Diana Wechsler. Both consider artistic production as a montage, in which things, places and time can be reconfigured. Both also approach the experience of images not on the basis of chronological and logocentric order, like in classical historicism, but rather on the basis of a recognition of images' density of meaning and expressive power capable of destabilizing the epistemological patterns of art history.

  3. Bridging the Particle Physics and Big Data Worlds

    Science.gov (United States)

    Pivarski, James

    2017-09-01

    For decades, particle physicists have developed custom software because the scale and complexity of our problems were unique. In recent years, however, the ``big data'' industry has begun to tackle similar problems, and has developed some novel solutions. Incorporating scientific Python libraries, Spark, TensorFlow, and machine learning tools into the physics software stack can improve abstraction, reliability, and in some cases performance. Perhaps more importantly, it can free physicists to concentrate on domain-specific problems. Building bridges isn't always easy, however. Physics software and open-source software from industry differ in many incidental ways and a few fundamental ways. I will show work from the DIANA-HEP project to streamline data flow from ROOT to Numpy and Spark, to incorporate ideas of functional programming into histogram aggregation, and to develop real-time, query-style manipulations of particle data.

  4. [6.-9. novembrini 2007 leidis aset üritus "Eesti kirjanikud Eesti raamatukogudes"

    Index Scriptorium Estoniae

    2007-01-01

    Ürituse "Eesti kirjanikud Eesti raamatukogudes" raames käisid Lääne- ja Ida-Virumaa raamatukogudes Jürgen Rooste, fs, Igor Kotjuh ja Mihkel Kaevats; Viljandi- ja Valgamaal Jan Kaus, Doris Kareva, Maarja Kangro, Indrek Koff ja Maire Liivamets; Hiiu- ja Läänemaal käisid Diana Leesalu, Eia Uus ja Kaarel B. Väljamäe; Põlva- ja Võrumaal olid Karl Martin Sinijärv, Kivisildnik, Indrek Hirv ja Teet Kallas; Tartu- ja Jõgevamaal Tarmo Teder, Hannes Varblane, Kadri Kõusaar ja Toomas Liiv; Raplamaal Berk Vaher, Piret Bristol, Jürgen Kaldmaa ja Heiki Vilep; Järvamaal Berk Vaher, Piret Bristol, Mathura ja Kristiina Ehin

  5. Utilidad de la monitorización de niveles de fármaco en la optimización del tratamiento biológico en la enfermedad inflamatoria intestinal

    OpenAIRE

    Vera Rivero, Francisco Miguel

    2017-01-01

    El 15% de los pacientes con enfermedad de Crohn (EC) y de colitis ulcerosa (CU) está en tratamiento con fármacos biológicos. Los anti TNF son de primera línea. Un 30% no responde a ellos, y un 40% de los que responden pierde eficacia. Cuando esto ocurre el manejo clínico, basado en valores analíticos, índices clínico-endoscópicos de actividad o pruebas de imagen, incluye intensificar de forma empírica la dosis, cambiar a otro fármaco anti TNF o a otra diana terapéutica. La presencia de anticu...

  6. Analysis of Movie I Am Not Stupid 2: Parenting Style 分析《小孩不笨2》电影的父母教育法

    Directory of Open Access Journals (Sweden)

    Mariana Mariana

    2015-04-01

    Full Text Available This paper, through Singaporean movie I am not Stupid 2, analyzes the relation between parenting and children’s growth process and also the action of parents should do to offer children for having a good growth process. Research was done based on Baumrind theory about parenting analysis to what kind of parenting that the parents of the movie I am not Stupid 2 offer to their children. Research used literature study to summarize, arrange, and analyze of Diana Baumrind as basis of the research. The results show that Tom and Jerry’s parents or Cheng Cai’s father used authoritarian parenting style. Research suggests that the best parenting style is authoritative parenting because this type of parenting does not only concern about the prominence of rules or regulations in the family, but also the affection of parents towards the children. Therefore, the family will certainly become more harmonious. 

  7. De la postveritat a la postètica

    OpenAIRE

    Alsius, Salvador

    2017-01-01

    L'última nit d'agost de 1997, Diana de Gal·les moria després d'haver tingut un accident de cotxe al túnel del pont de l'Alma de París. Entre les circumstàncies que van envoltar aquest succés hi va haver l'actuació dels paparazzis que aquell mateix vespre, com en jornades anteriors, havien assetjat incansablement "la princesa del poble" i el seu acompanyant. En les següents vint-i-quatre hores, els mitjans de comunicació de tot el món, en totes les llengües imaginables, no van parlar d'altra c...

  8. VERBALIZACIÓN EN DOS MUJERES OCTOGENARIAS - VERBALIZATION IN TWO OCTOGENARIAN WOMEN

    Directory of Open Access Journals (Sweden)

    JHONNY LOAIZA GARCÍA

    2010-06-01

    Full Text Available This research was developed according to the criteria of the empiric analytic paradigm. It includes a descriptive analysis about the verbal fluency of two people who are more than 80 years old who consider language the basic way to express themselves. The necessary information was got by applying the WAIS verbal test which evaluates language in some specific areas.Besides applying the test, it was also used an interview which showed some important data about each patient’s personal history. The results were analyze according to a clinic optic, supported by the analysis proposed by Josette Benavides (1984 in character evaluation techniques. This research also follows the knowledge contributed by the memory clinic of Universidad Javeriana, directed by Patricia Montañes, Diana Matallana and Carlos Cano, authors of many studies related to the elderly people in Colombia

  9. Análisis genético y funcional de biomarcadores en cáncer colorrectal y estudio proteómico del papel de snail en fibroblastos tumorales

    OpenAIRE

    Peláez García, Alberto, Alberto

    2015-01-01

    El cáncer colorrectal CCR, es el tercer cáncer más frecuente en el mundo con una alta mortalidad situándolo como el segundo cáncer con mayor número de fallecimientos en España. Esta alta mortalidad se debe al diagnosticó en estadios avanzados de la enfermedad en un amplio número de pacientes. Por ello, la investigación actual se centra en la identificación de biomarcadores para la detección temprana como el desarrollo de nuevas dianas terapéuticas. Para lograr estos objetivos es necesario un ...

  10. Ecos de la novela griega en el Renacimiento

    Directory of Open Access Journals (Sweden)

    Lourdes Rojas Alvarez

    2012-09-01

    Full Text Available The Greek novel, a multifaceted fiction genre in prose, flourished between the first and the fourth Century A.D., had its continuation into the Byzantine literature. The significance of the Greek novels reached the Renaissance with Longus and his Daphnis and Chloe, that influenced Sanazzaro's Arcadia in Italy, or Jorge de Montemayor's Diana, in Spain. It also had a certain influence in Cervantes' Galatea and even in his Quijote. Sidney's Arcadia is also tributary to the theme, such as Honoré d' Urfé's Astrea, in France. In this paper I want to point out the influence of the Greek novel in Shakespeare I will focus in The Tempest, comedy in five acts, that reveals great affinity with the Greek novel of love and adventures of Longus, Xenophon of Ephesus and Achilles Tatius, as well as in the utopian novel

  11. Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature

    Directory of Open Access Journals (Sweden)

    Aldag C

    2016-11-01

    Full Text Available Caroline Aldag,1,* Diana Nogueira Teixeira,1,* Phillip S Leventhal2 1Merz Pharmaceuticals GmbH, Frankfurt am Main, Germany; 24Clinics, Paris, France *These authors contributed equally to this work Abstract: Skin aging is primarily due to alterations in the dermal extracellular matrix, especially a decrease in collagen I content, fragmentation of collagen fibrils, and accumulation of amorphous elastin material, also known as elastosis. Growth factors and cytokines are included in several cosmetic products intended for skin rejuvenation because of their ability to promote collagen synthesis. Matrikines and matrikine-like peptides offer the advantage of growth factor-like activities but better skin penetration due to their much smaller molecular size. In this review, we summarize the commercially available products containing growth factors, cytokines, and matrikines for which there is evidence that they promote skin rejuvenation. Keywords: cosmetics, skin, aging, growth factor, cytokine, matrikine

  12. Vaba Läti ehitab / Margit Mutso

    Index Scriptorium Estoniae

    Mutso, Margit, 1966-

    2007-01-01

    13.-17.04. 2007 hindas rahvusvaheline žürii Läti parimaid arhitektuuriteoseid. Parim rekonstrueeritud ehitis oli büroohoone Riias Dzirnavu tn. 68 (arhitektid Aleksejs Birjukovs, Andis Silis). Parim tööstushoone oli Ventspilsis asuv mahlakontsentraatide käitlus- ja laohoone (arhitektid Aija Kokina, Andris Kokins, Krista Strelita-Strele). Bürookategooria võiduprojektiks valiti Liepajas Zivju tn. 11/13 paiknev kontorihoone (arhitektid Diana Zalane, Artis Rokis). Parima elamu tiitli pälvis Jurmalas Jura tn. 32 asuv maja (arhitektid Janis Alksnis, Nora Saulespurena, Andris Rubenis). Eramajadest oli parim suvemaja Pavilostas (arhitekt Janis Sauka). Parima maastikuarhitektuur-väikevormi preemia said Gvido Rekis, Anita Neilande, Andris Kausenieks, Didzis Oshenieks Ventspilsi dzhungliraja eest. Sisekujunduspreemia sai originaaldisainiga ekspositsioonikapslitega Grindeksi farmaatsiatoodete näidisteruum Riias

  13. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: rockansamblite Sõpruse Puiestee, Dirty Diana ja Shotgun Suicide peost 15. veebr. Rock Cafés, folklooripeost Pärnus Rääma Nooruse majas, klubi Woodstocki 5. sünnipäeva tähistamisest 15. ja 16. veebr., Ultima Thule kontserdist 15. veebr. Tartu Rockiklubis, festivalist "Eesti teater Estonias"16.-23. veebr.Rahvusooperis Estonia, kontsertidest "Küünlavalgel" 19.-21. veebr. Tallinna Matkamajas, prantsuse duo 2G Kevadjazzil 2008 15. veebr. Tartus Athena keskuses, Raadio Elmari juubelipeost 22. veebr. Pärnu kuursaalis, rootsi bändi Soilwork ja Path Of No Return kontserdist 20. veebr. Tallinnas Rock Cafés

  14. Mitmekülgne eesti lastekirjandus [2006. a.] / Jaanika Palm

    Index Scriptorium Estoniae

    Palm, Jaanika, 1973-

    2007-01-01

    Arvustus: Tungal, Leelo. Lätikeelne jäätis ja teisi luuletusi. Tallinn : Tuum, 2006 ; Trull, Ilmar. Musta kassi mumba. Tallinn : Eesti Ekspressi Kirjastus, 2006 ; Wimberg. Põngerjate laulud. Tallinn : Varrak, 2006 ; Muidugi, Eino. Lõbus pere ütleb tere! Tallinn : Koolibri, 2006 ; Nemvalts, Urmas. Väikeste meeste jutud. [Tallinn] : Grenader, 2006 ; Kangro, Maarja, Kangro, Kirke. Puuviljadraakon. Tallinn : Koolibri, 2006 ; Kilkson, Tiina. Pisikese Peetri pikk pühapäev. Tallinn : Koolibri, 2006 ; Pelmas, Elsa. Sussipäkapikk Siisi seiklused. Tallinn : TEA Kirjastus, 2006 ; Sauter, Peeter. Laiskade laste raamat. Tallinn : Huma, 2006 ; Kivirähk, Andrus. Leiutajateküla Lotte. Tallinn : Eesti Joonisfilm, 2006 ; Ulman, Mihkel. Nukkude teater. Tartu : Elmatar, 2006 ; Rannap, Jaan. Roheline kindlus. Tallinn : Tiritamm, 2006 ; Vallik, Aidi. Narkohollo ehk Florose vabastamine. Haapsalu : Lugu-Loo, 2006 ; Leesalu, Diana. Mängult on päriselt. Tallinn : Tänapäev, 2006 ; Laidla, Siiri. Pärnaõietee. Tallinn : Canopus, 2006

  15. Mitmekülgne eesti lastekirjandus [2006. a.] / Jaanika Palm

    Index Scriptorium Estoniae

    Palm, Jaanika, 1973-

    2008-01-01

    Arvustus: Tungal, Leelo. Lätikeelne jäätis ja teisi luuletusi. Tallinn : Tuum, 2006 ; Trull, Ilmar. Musta kassi mumba. Tallinn : Eesti Ekspressi Kirjastus, 2006 ; Wimberg. Põngerjate laulud. Tallinn : Varrak, 2006 ; Muidugi, Eino. Lõbus pere ütleb tere! Tallinn : Koolibri, 2006 ; Nemvalts, Urmas. Väikeste meeste jutud. [Tallinn] : Grenader, 2006 ; Kangro, Maarja, Kangro, Kirke. Puuviljadraakon. Tallinn : Koolibri, 2006 ; Kilkson, Tiina. Pisikese Peetri pikk pühapäev. Tallinn : Koolibri, 2006 ; Pelmas, Elsa. Sussipäkapikk Siisi seiklused. Tallinn : TEA Kirjastus, 2006 ; Sauter, Peeter. Laiskade laste raamat. Tallinn : Huma, 2006 ; Kivirähk, Andrus. Leiutajateküla Lotte. Tallinn : Eesti Joonisfilm, 2006 ; Ulman, Mihkel. Nukkude teater. Tartu : Elmatar, 2006 ; Rannap, Jaan. Roheline kindlus. Tallinn : Tiritamm, 2006 ; Vallik, Aidi. Narkohollo ehk Florose vabastamine. Haapsalu : Lugu-Loo, 2006 ; Leesalu, Diana. Mängult on päriselt. Tallinn : Tänapäev, 2006 ; Laidla, Siiri. Pärnaõietee. Tallinn : Canopus, 2006

  16. The public of media events

    Directory of Open Access Journals (Sweden)

    Christian Morgner

    2010-12-01

    Full Text Available This article focuses on the growing importance of large-scale events and their central role in a globalised media world in relation to public reactions and public involvement. The peculiar structure of such events requires a different understanding of mass communication and its audience. Therefore, the audience is further examined with regard to its impact on and inclusion in the media itself. Consequently, questions are raised as to how the public is incorporated, the form this inclusion takes and the effect that this has on the audience’s participation.The article examines different types of semantic inclusion, with a focus on emotional reactions towards three different media events: the Titanic disaster, the assassination of John F. Kennedy, and the death of Princess Diana.

  17. The Representation of Fatherhood by the Arab Diaspora in the United States

    Directory of Open Access Journals (Sweden)

    Marta Bosch

    2008-01-01

    Full Text Available This article1 analyzes three debut novels –Alicia Erian’s Towelhead (2005, Laila Halaby’s West of the Jordan (2003, and Diana Abu-Jaber’s Arabian Jazz (1993– in order to explore the representation of fatherhood by the Arab diaspora in the United States. To do so, it will draw on Ralph La Rossa’s notion of “new father”, and on Julie Peteet’s and Daniel Monterescu’s ideas about Arab masculinity. It will then analyze the main father figures in the novels under the light of these concepts. It will finally conclude that the different existing models of Arab fatherhood move from traditionalism to liberalism, and that allows the possibility of “new fatherhoods” to emerge.

  18. Ex-Votos às Ninfas em Portugal

    OpenAIRE

    Joaquim Rodrigues dos SANTOS JUNIOR; Mario CARDOZO

    2009-01-01

    A expansào na Península Hispánica dos cultos consagrados às divindades do Panteáo romano, revelada em numerosos textos epigráficos dedicados a Júpiter, Diana, Minerva, Juno, Marte, Cerei, etcétera, e bem assim dos cultos de origem oriental que as relaçôes militares, comerciáis e políticas do Imperio com os povos da Asia e de África haviam introduzido em Roma —cultos a Se rapis, I sis, Cibele, Mitra, etc.— nao logrou dissipar, na religiosidade ancestral do íncola do Ocidente, os cultos que, an...

  19. Calibrating and validating a FE model for long-term behavior of RC beams

    Directory of Open Access Journals (Sweden)

    Tošić Nikola D.

    2014-01-01

    Full Text Available This study presents the research carried out in finding an optimal finite element (FE model for calculating the long-term behavior of reinforced concrete (RC beams. A multi-purpose finite element software DIANA was used. A benchmark test in the form of a simply supported beam loaded in four point bending was selected for model calibration. The result was the choice of 3-node beam elements, a multi-directional fixed crack model with constant stress cut-off, nonlinear tension softening and constant shear retention and a creep and shrinkage model according to CEB-FIP Model Code 1990. The model was then validated on 14 simply supported beams and 6 continuous beams. Good agreement was found with experimental results (within ±15%.

  20. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to “Appl’In® polyphenolic apple extract powder (Malus domestica)” and reduction of post-prandial glycaemic responses pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Diana Naturals pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of France, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to “Appl....... The Panel considers that reduction of post-prandial glycaemic responses (as long as post-prandial insulinaemic responses are not disproportionally increased) may be a beneficial physiological effect. The applicant provided one published and two unpublished human studies, three animal studies and two...... in vitro studies as pertinent to the claim. The Panel notes that the food used in one human study did not comply with the specifications of the food which is the subject of the claim and considers that no conclusion can be drawn from this study for the scientific substantiation of the claim. In two other...

  1. In Praise of Ambiguity: Musical Subtlety and Merleau-Ponty

    Directory of Open Access Journals (Sweden)

    Tiger C. Roholt

    2013-01-01

    Full Text Available When a jazz, rock, or hip-hop drummer strikes certain notes in each measure slightly late, instead of hearing the degree to which those notes are late, we typically hear the effects of those variations; namely, a groove, the "feel" of a rhythm. Slight variations of pitch function similarly. In this essay, I argue that certain analytic theorists go astray due to their preoccupation with the variations themselves. By invoking Maurice Merleau-Ponty's insights into subtle visual perceptions, and his notion of perceptual indeterminacy, I avoid an account of musical subtlety suggested by Daniel Dennett that is too coarse-grained, as well as the bleak conclusion that certain musical subtleties are ineffable, Diana Raffman's view. I conclude that elements of music that are perceived ambiguously can perform a positive function in such aesthetic experiences: they can mediate or foster emergent qualities; moreover, they must be perceived in this way to do so.

  2. Las habilidades motoras en niños víctimas de maltrato físico

    OpenAIRE

    Eulalia María Amador Rodero

    2013-01-01

    Objetivo: Aplicar un programa de habilidades motoras en niños víctimas de maltrato físico. Materiales y métodos: Se trata de un estudio cuasiexperimental en el que se aplica el programa de Estimulación de Habilidades Motoras formulado por el grupo POYMOCOR de la Universidad Libre a una población diana conformada por 16 niños víctimas de maltrato físico en la ciudad de Barranquilla (Colombia); los cuales cumplieron con los criterios de inclusión: haber sido víctimas de maltrato físico y no pad...

  3. El feminicidio: realidad o mentira dentro de la política pública colombiana

    OpenAIRE

    Correa Corredor, Marien Yolanda; Mendoza-Pérez, Noris; Rincón-Guauque, Clara Milena; Arenas-Rueda, Yenny Marcela; Aguilar-Noriega, Erick Johann; Villamizar-Mendoza, José Eliecer

    2014-01-01

    Este ejercicio académico parte del estado del arte del feminicidio en seis países de América Latina —entre ellos Colombia— durante los dos últimos lustros, para evidenciar la necesidad de proponer la tipificación del feminicidio, no como agravante del homicidio, sino como delito autónomo en la legislación colombiana. Se escribió en la línea de política pública,desde las teorías del feminicidio de Diana Russell y de Marcela Lagarde para proteger a las mujeres víctimas, y fue el resultado de do...

  4. Feminicídios: conceitos, tipos e cenários

    Directory of Open Access Journals (Sweden)

    Stela Nazareth Meneghel

    Full Text Available Resumo Este texto é um ensaio teórico que discute os conceitos, os tipos e os cenários de feminicídios e apresenta algumas propostas para a prevenção destas mortes prematuras, injustas e evitáveis. O texto traz o conceito original de femicídio proposto por Diana Russel e Jane Caputti, caracteriza tipos e mostra cenários novos e antigos onde estes crimes ocorrem. Aponta o patriarcado, entendido como sistema hierárquico de poder entre homens e mulheres, como um dos principais determinantes destas mortes. Finaliza apresentando ações e propostas para prevenir e combater estes crimes de gênero.

  5. In memoriam 2002

    Index Scriptorium Estoniae

    2003-01-01

    Maailm: Kenneth Armitage (18. VII 1916-22. I), Eduardo Chillida (10. I 1924-19. VIII), Ruth Handler (4. IV 1916-27. IV), Yousuf Karsh (23. XII 1908-14. VII), Roberto Matta (11. XI 1911-23. XI). Eesti: Endel Kaldmäe (12. VII 1918-15. XII), Tiia Kelomees-Johannson (8. IX 1965-11. VI), Salme Kirsimäe (6. XI 1919-1. IV), Maret Kuke (9. X 1926-2. VII), Diana Laev (21. XI 1919-31. VIII), Pauline Leps (16. XI 1903-5. III), Avo-Himm Looveer (16. VIII 1941- 1. V), Jüri Palm (14. IV 1937-27. IV), Agu Pilt (26. VIII 1951-11. III), Valve Pormeister (13. IV 1922-27. X), Eugen Sacharias (21. IV 1906-13. III), Lilian Schönberg (25. IV 1934-10. X), Laine Sisa (12. II 1931-20. II)

  6. Numerical and experimental analysis of time-dependent load transfer in reinforced concrete columns

    Directory of Open Access Journals (Sweden)

    L. T. Kataoka

    Full Text Available A study was conducted to assess the influence of the steel reinforcement ratio in concrete columns on their properties of creep and shrinkage. Experimental tests and three-dimensional finite element-based simulations of the experimental curves from plain concrete cylinders and plain concrete columns derived by curve fitting were performed using the ACI 209 model available in DIANA 9.3. Columns with longitudinal reinforcement ratios of 0%, 1.4% and 2.8%, loaded to 30% and 40% of their 7-day compressive strength, were investigated. The results indicated that numerical simulation does not predict experimental data for a long period. However, simulations fitted with experimental curves derived from plain concrete columns presented values close to those of experimental data for 91 days.

  7. Ecstatic stigmatics and Holy anorexics: medieval and contemporary.

    Science.gov (United States)

    Farber, Sharon Klayman

    2003-01-01

    As has been shown and explained, the stigmata and other mortifications of the flesh can serve as survival tools for someone who has been severely traumatized, devout Christian or unbeliever alike. When Diana, Princess of Wales, was killed, this nonreligious woman came to be regarded by her admirers as a popular saint who wanted nothing more than to help and serve others. Despite her wealth, she became a waif in the popular imagination, and like many others who suffered great psychic pain, she too inflicted further pain and suffering on herself through starving herself, binging and purging, and cutting herself. This suffering was her visible stigmata, inspiring great popular devotion. When she died, millions cried, carrying candles in the streets as they listened to Elton John's song to this suffering woman whose light flickered "like a candle in the wind".

  8. Models animals per a l'estudi de la diabetis

    OpenAIRE

    Roglans, Núria; Alegret, Marta; Laguna, Juan Carlos

    2011-01-01

    La diabetis mellitus (DM) s'origina per mancança dels efectes de la insulina, bé perquè el pàncrees és incapaç de produir-ne, bé perquè els seus òrgans diana no responen adequadament, o per una combinació d'ambdues situacions, amb l'aparició d'hiperglucèmia, poliúria i polidípsia. En absència total de la insulina (DM tipus 1) hi ha metabolisme accelerat de proteïna muscular i greix, que pot acabar en cetoacidosi metabòlica i mort. Amb activitat insulínica residual (DM tipus 2),...

  9. Estudio de la prevalencia de la infección por virus del papiloma humano, en mujeres pertenecientes al programa de prevención y detección precoz de cáncer de cuello uterino de Castilla y León

    OpenAIRE

    García Villanueva, Sara

    2016-01-01

    La relación entre el cáncer de cérvix y el virus del papiloma humano está bien definida. En nuestro trabajo, se ha estudiado la prevalencia de la infección del virus del papiloma humano, en las mujeres pertenecientes al sistema sanitario de Castilla y Leon, que hayan participado en el programa de prevención y detección precoz de cáncer de cuello uterino. Es un programa con un tipo de cribado poblacional, cuya población diana son las mujeres entre los 225 y 64 años de edad, que hayan man...

  10. The Unappreciated Ramifications of the "Triple Obstetric Tragedy".

    Science.gov (United States)

    Quigley, James

    2015-06-01

    The untimely death of a young Princess of Wales reverberated around the world in August 1997. Diana, Princess of Wales, was not, however, the first holder of that title to suffer an early demise. Princess Charlotte of Wales was fifteen years younger and died exactly one hundred and eighty years earlier. A national feeling of grief and desolation consumed the nation in the same way as it did following the death of the "People's Princess" in the twentieth century. Her death during childbirth led to a change in the practice of obstetrics and a succession crisis in the British monarchy. But were the consequences of the fateful night of 6th November 1817 to be even more profound, indirectly contributing to war in Europe a century later?

  11. Role of Pax4 and Pax8 in pancreatic islets physiology and patophysiology

    OpenAIRE

    Jiménez-Moreno, Carmen M.

    2015-01-01

    Programa de Doctorado en Biotecnología y Tecnología Química La Diabetes Mellitus (DM) es una enfermedad metabólica crónica, caracterizada por hiperglucemia debida a un déficit absoluto o parcial en la secreción de insulina por parte de las células ß pancreática. La etiología deriva bien de una destrucción autoinmune de las células ß productoras de insulina (DM Tipo 1; DMT1) o a una combinación entre la resistencia a insulina de los tejidos diana y la secreción insuficiente de insulina por ...

  12. Búsqueda de nuevos agentes antiprotozoarios selectivos

    Directory of Open Access Journals (Sweden)

    Vladímir V. Kouznetsov, PhD, DSc* Carlos Mario Meléndez Gómez, Químico**

    2009-04-01

    Full Text Available Se da la información general sobre los fármacos antiprotozoarios que están usándose en clínica, se discuten nuevas dianas de los parásitos protozoarios útiles en la búsqueda de nuevos agentes antiprotozoarios, enfocando la atención al rol biológico de las proteasas de los parásitos protozoarios. Esta información importante será útil para los estudiantes e investigadores que se interesen a los problemas de química medicinal (un área naciente en Colombia cuál aporta mucho al desarrollo de ciencias médicas. [Kouznetsov V, Meléndez C. Búsqueda de nuevos agentes antiprotozoarios selectivos. MedUNAB2009; 12:33-45

  13. List of reviewers

    Directory of Open Access Journals (Sweden)

    Neven Vrček

    2012-12-01

    Full Text Available József Tar Institute of Intelligent Engineering Systems, BudapestGašper Mušič University of Ljubljana, SloveniaWilliam Steingartner Technical University of Košice, SlovakiaIvana Jugović Institute for Social Research, CroatiaGilda Pecaric University of Zagreb, CroatiaElisabeth Pergler Evolaris next level GmbH, AustriaAlen Lovrenčić University of Zagreb, CroatiaPeter Andreae Victoria University, New ZealandJan Paralic Technical University Kosice, SlovakiaDiana Šimić University of Zagreb, CroatiaNadica Hrgarek MED-EL Medical Electronics, AustriaJadranka Stojanovski Rudjer Boskovic Institute, CroatiaMilan Ambroz Human Resources Professional, SloveniaKatarina Žager University of Zagreb, CroatiaKresimir Fertalj University of Zagreb, Croatia

  14. SOLVER Un agente que te enseña a resolver problemas de matemáticas

    OpenAIRE

    Sánchez Martín, Daniel

    2012-01-01

    Proyecto Fin de Carrera leído en la Universidad Rey Juan Carlos en el curso académico 2011/2012. Tutor del Proyecto: Diana Pérez Marín El uso de las tecnologías de la información ha pasado a formar parte de nuestra vida cotidiana en casi cualquier actividad diaria, este proyecto fin de carrera se centra en las posibilidades que ofrece las tecnologías de la información en el ámbito de la enseñanza. En concreto, el objetivo es el desarrollo de un sistema informático de tipo Agente Convers...

  15. Transnational Literature, November 2011: Articles, Interviews etc. (complete

    Directory of Open Access Journals (Sweden)

    2011-11-01

    Full Text Available This file includes five articles: Nicholas Birns, 'The Solid Mandala and Patrick White's Late Modernity'; Md Rezaul Haque, 'The Nation and One of its Fragments in Kanthapura'; Diana Jovasiene, 'Herkus Kuncius' Novel The Ornament as a postmodern analaysis of Contemporary Lithuanian Society'; Holly E. Martin, 'Falling into America: The Downside of Transnational Identities in Hi Jin's A Good Fall'; and Umme Salma, 'Woman and the Empire in Alexander Pope's The Rape of the Lock: A Rereading'; one review essay, Dorothy Driver, 'Trauma, Memory and Narrative in South Africa: Interviews'; two interviews with Amy T. Matthews and Altaf Tyrewala; an English translation by Mohammad Quayum of Istrijatir Abanati (Woman's Downfall by Rokeya Sakhawat Hossain; and 'Fiji without Snorkelling: a report from the First Fiji Literary Festival.'

  16. PENGEMBANGAN AUGMENTED REALITY SEBAGAI MEDIA PEMBELAJARAN PENGENALAN KOMPONEN PNEUMATIK DI SMK

    Directory of Open Access Journals (Sweden)

    Ilmawan Mustaqim

    2017-07-01

    Full Text Available Guru kesulitan menyampaikan materi apabila sekolah tidak memiliki benda sesungguhnya yang digunakan sebagai praktikum. Pneumatik menjadi pelajaran wajib di SMK jurusan teknik mekatronika dan teknik otomasi. Pneumatik sering digunakan dalam industri manufaktur. Tujuan dari penelitian adalah menghasilkan rancang bangun dan unjuk kerja augmented reality sebagai media pembelajaran. Metode pengembangan yang digunakan adalah ADDIE adaptasi  dari William W. Lee dan Diana L. Owens yang meliputi 1  analisis, 2 perencanaan, 3 pengembangan dan implementasi, dan 4 evaluasi. Hasil dari rancang bangun berupa aplikasi Pneumatik AR dan Marker AR. Layout disusun menggunakan software CorelDraw X7, sedangkan model 3D dibuat menggunakan bantuan software Blender 3D. seluruh bahan disatukan menggunakan software Unity 3D dengan bahasa pemrograman C#. Hasil unjuk kerja diperoleh bahwa aplikasi dapat berjalan dengan baik pada beberapa merk dan type smartphone yang digunakan untuk pengujian. Terdapat beberapa kesalahan penampilan gambar 3d pada beberapa marker dengan perbedaan yang kurang spesifik.

  17. Use of multiple cluster analysis methods to explore the validity of a community outcomes concept map.

    Science.gov (United States)

    Orsi, Rebecca

    2017-02-01

    Concept mapping is now a commonly-used technique for articulating and evaluating programmatic outcomes. However, research regarding validity of knowledge and outcomes produced with concept mapping is sparse. The current study describes quantitative validity analyses using a concept mapping dataset. We sought to increase the validity of concept mapping evaluation results by running multiple cluster analysis methods and then using several metrics to choose from among solutions. We present four different clustering methods based on analyses using the R statistical software package: partitioning around medoids (PAM), fuzzy analysis (FANNY), agglomerative nesting (AGNES) and divisive analysis (DIANA). We then used the Dunn and Davies-Bouldin indices to assist in choosing a valid cluster solution for a concept mapping outcomes evaluation. We conclude that the validity of the outcomes map is high, based on the analyses described. Finally, we discuss areas for further concept mapping methods research. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Carotenoids and lycopene content in fresh and dried tomato fruits and tomato juice

    Directory of Open Access Journals (Sweden)

    Andrea Mendelová

    2013-01-01

    Full Text Available Important component of the tomato are carotenoid dyes, especially lycopene. The importance of lycopene in the diet of people in recent years has grown mainly for its pharmacological effects due to its ability to reduce the risk of carcinoma diseases and prevention of cardiovascular diseases. The aim of this work was to analyze the content of total carotenoids and lycopene in 8 varieties of tomato and to monitor dynamic changes after their different treatments (heating, drying. The experiment included following tomato varieties: Bambino F1, Darina F1, Diana F1, Denár, Milica F1, Orange F1, Paulína F1, Šejk F1.We found that processing of tomato fruits into juices and dried slices positively affected the presence of carotenoids and lycopene. Processing leads to an increase in the content of carotenoids that can be attributed to better availability of these components in the human body.

  19. Análise de vigas mistas de aço e concreto pertencentesa pisos de baixa altura em situação de incêndio: ênfase à influência dos modelos constitutivos do concreto

    Directory of Open Access Journals (Sweden)

    F. M. Rocha

    Full Text Available A incorporação do perfil de aço na laje de concreto, como ocorre nos pisos mistos de baixa altura (slim floor, garante revestimento contrafogo ao aço, melhorando o desempenho da viga de aço frente às ações da corrosão e do incêndio. Com a finalidade de avaliar o desempenhotérmico e estrutural desse sistema construtivo foram desenvolvidos modelos numéricos de vigas mistas de aço e concreto parcialmente revestidas com o uso do pacote computacional DIANA. No que diz respeito aos modelos constitutivos dos materiais, não foi possível representaras relações apresentadas no EUROCODE 4 e na ABNT NBR 14323:2013, por incompatibilidade dessas com o DIANA, sendo então adotadosmodelos alternativos. Em seguida, foram construídos modelos numéricos à temperatura ambiente e em temperatura elevada, contemplandoas opções disponíveis e convenientes para as relações constitutivas do aço e do concreto. Também foram avaliados parâmetros como: (a onível de interação entre o aço e concreto, bem como (b a melhor configuração para os parâmetros térmicos do concreto a fim de se obter umaresposta mais realista do comportamento das vigas pertencentes ao sistema slim floor em situação de incêndio.

  20. Detección de Leishmania spp. en base al gen que codifica la proteína HSP20

    Directory of Open Access Journals (Sweden)

    Ana M Montalvo

    Full Text Available Objetivos. Explorar una nueva diana para el diagnóstico molecular de Leishmania. Materiales y métodos. Se evaluó la utilidad del gen que codifica la proteína de choque térmico de 20kDa (hsp20 para la detección de Leishmania por medio de la reacción en cadena de la polimerasa (PCR.Se normalizó la PCR y se determinaron los parámetros analíticos, así como la validez y seguridad diagnóstica y la concordancia con la PCR-18S. Se evaluó la PCR-hsp20 con ADN obtenido de un grupo de muestras clínicas de distinta procedencia. Resultados. Los parámetros analíticos resultaron adecuados. La sensibilidad obtenida fue de 86% y la especificidad del 100%, la concordancia con el método de referencia resultó buena (κ = 0,731, lo que apoya su posible uso para el diagnóstico. La posibilidad de identificación posterior de la especie mediante secuenciación del producto amplificado le confiere una ventaja adicional. Conclusiones. Se demuestra la utilidad de este gen como una nueva diana para la detección del género Leishmania. Debido a su potencial, se recomienda mejorar la sensibilidad del procedimiento y realizar su evaluación en diversas regiones endémicas.

  1. El Abencerraje: una lección de virtud en los albores del confesionalismo filipino

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    Torres Corominas, Eduardo

    2013-06-01

    Full Text Available Between 1561 and 1565 the three known versions of El Abencerrage —Crónica, Diana and Inventario— were printed. The moral lesson of these works, based on the principles of the humanism, is opposite to the process of confessionalization promoted by the Hispanic Monarchy in those dates. From the reconstruction of those three writing contexts —and knowing the courtesan faction to which the successive adapters of the work belonged: Jiménez de Embún’s servant, Jorge de Montemayor and Antonio de Villegas— this work attempts to prove, from the studies on the Spanish Court, how the first Spanish Moorish novel was, understood as an ideological discourse, a frontal attack against Philip the II’s confessionalism arised from the political opposition.Entre 1561 y 1565, vieron la luz las tres versiones de El Abencerraje hoy conocidas —Crónica, Diana e Inventario— cuya lección moral, basada en los principios del mejor humanismo, contrastaba con el incipiente proceso de confesionalización emprendido por la Monarquía hispana en esas mismas fechas. A partir de la reconstrucción de aquellos tres contextos de escritura —y encuadrando faccionalmente a los sucesivos refundidores de la pieza: el servidor de Jiménez de Embún, Jorge de Montemayor y Antonio de Villegas— el presente trabajo trata de demostrar, desde los estudios sobre la Corte en España, cómo la primera novela morisca de nuestras letras constituyó, en tanto que discurso ideológico, un ataque frontal contra el confesionalismo filipino surgido desde la filas de la oposición política.

  2. Central online quality assurance in radiology. An IT solution exemplified by the German Breast Cancer Screening Program

    International Nuclear Information System (INIS)

    Czwoydzinski, J.; Girnus, R.; Sommer, A.; Heindel, W.; Lenzen, H.; Universitaetsklinikum Muenster

    2011-01-01

    Purpose: Physical-technical quality assurance is one of the essential tasks of the National Reference Centers in the German Breast Cancer Screening Program. For this purpose the mammography units are required to transfer the measured values of the constancy tests on a daily basis and all phantom images created for this purpose on a weekly basis to the reference centers. This is a serious logistical challenge. To meet these requirements, we developed an innovative software tool. Materials and Methods: By the end of 2005, we had already developed web-based software (MammoControl) allowing the transmission of constancy test results via entry forms. For automatic analysis and transmission of the phantom images, we then introduced an extension (MammoControl DIANA). This was based on Java, Java Web Start, the NetBeans Rich Client Platform, the Pixelmed Java DICOM Toolkit and the ImageJ library. Results: MammoControl DIANA was designed to run locally in the mammography units. This allows automated on-site image analysis. Both results and compressed images can then be transmitted to the reference center. We developed analysis modules for the daily and monthly consistency tests and additionally for a homogeneity test. Conclusion: The software we developed facilitates the immediate availability of measurement results, phantom images, and DICOM header data in all reference centers. This allows both targeted guidance and short response time in the case of errors. We achieved a consistent IT-based evaluation with standardized tools for the entire screening program in Germany. (orig.)

  3. Semiótica da Comunicação Polí­tica | Semiotic of the Political

    Directory of Open Access Journals (Sweden)

    Eric Landowski

    2008-11-01

    Full Text Available O ensaio propõe, na sua primeira parte, uma discussão geral sobre o estatuto da semiótica discursiva e os rumos que a disciplina vem tomando nos últimos dez anos, desde que passou a se ocupar, mais diretamente, de um sentido sensí­vel (um sentido cuja particularidade é justamente a de ser sentido. Nesse percurso, procura-se mostrarcomo, retomando de modo explí­cito a influência inicial da fenomenologia, as pesquisas recentes vêm evoluindo de uma semiótica dos discursos enunciados para uma semiótica da experiência sensí­vel, passando por uma semiótica das situações. Para mostrar, concretamente,em torno de quais problemáticas teóricas a semiótica poderia orientar seus desenvolvimentos futuros, realiza-se, na segunda parte, uma análise dos regimes de sentido instaurados por um caso particular no domí­nio do polí­tico: a morte da Princesa Diana e a sua repercussão.Abstract: The essay proposes a general discussion of the principles and aims of the so-called Discoursive Semiotics, putting the stress on the amplitude of its evolution during the last three decades. Initially limited to a strict application of structuralist methods ofanalysis to uttered discourses, the discipline assumes today the form of a sociosemiotics focussed on global "situations". From this point of view, perception and the phenomenological dimension of sensorial experience become relevant variables in the process of construction of meaning. Hence the present renewal of the reflexion on aesthesis and esthetics within the discipline. A brief analysis of the way how princess Diana's death was reconstructed by the media is presented as an example of the critical perspectives that such an approach allows to open, in particular, on the political level.

  4. Desempenho de cultivares de tomateiro para mesa em ambiente protegido Performance of fresh market tomato cultivars under protected cultivation

    Directory of Open Access Journals (Sweden)

    Ronan Gualberto

    2007-06-01

    Full Text Available Com o objetivo de avaliar a produção de cultivares de tomate de mesa, cultivadas em ambiente protegido, foi conduzido em 2003 um experimento na Universidade de Marília (SP, com dez híbridos (AF 4392, Carmen, Débora Max, Diana, Duradoro, Fanny, Raisa N, Séculus, Sheila e Tilila. O delineamento experimental foi blocos casualizados com quatro repetições e parcelas quatro plantas úteis. Ocorreram diferenças significativas (pThe yield of fresh tomato cultivars was evaluated under protected cultivation. The experiment was carried out in 2003, at the University of Marília. Ten hybrids (AF 4392, Carmen, Debora Max, Diana, Duradoro, Fanny, Raisa N, Seculus, Sheila, and Tilila were evaluated in a randomized complete blocks design, four replications and plots of four useful plants. There were significant differences (p50 mm yield was similar among all genotypes, ranging from 154.3 t ha-1 (AF 4392 hybrid to 125.2 t ha-1 (Debora Max hybrid, except for the hybrid Tilila (88.0 t ha-1, lower than the others. Hybrids AF 4392 (176 g and Duradoro (175 g were those with the heaviest fruits, although similar to hybrids Fanny (164 g, Sheila (155 g, Carmen (150 g, and Seculos (149 g. Hybrid Debora Max was the only one to present the ratio longitudinal:transversal diameter equal to 1,0. All other hybrids showed average for this ratio superior to 1,00.

  5. Síndrome metabólico en familiares de primer grado de pacientes con diabetes mellitus tipo 2 Metabolic syndrome in first degree relatives of patients with diabetes mellitus 2

    Directory of Open Access Journals (Sweden)

    Raúl Orlando Calderín Bouza

    2005-12-01

    Full Text Available Se realizó un estudio descriptivo y transversal de 340 personas divididas en 2 grupos, con y sin antecedentes patológicos familiares de diabetes mellitus tipo 2 (APF de DM2, con el objetivo de detectar si las que presentaban APF de DM2 tenían más hiperinsulinemia, presencia de síndrome metabólico, factores de riesgo cardiovascular asociados y lesión de órganos diana, expresados en hipertrofia del ventrículo izquierdo de los sujetos que no tenían dicho antecedente. Se obtuvo como resultado que la hiperinsulinemia estuvo presente en 96 pacientes con APF de DM2 (56,5 % y una significación de p = 0,001. El síndrome metabólico fue más frecuente en las personas con APF DM2 (90 para un 52,9 % y una significación de p = 0,000. La hipertrigliceridemia fue el marcador por excelencia del síndrome metabólico y el factor de riesgo que con más significación estadística se asoció a los sujetos con APF de DM2 (96: 52,9 % y una significación de p = 0,000. La hipertrofia ventricular izquierda (HVI se asoció como expresión de lesión de órganos diana a los sujetos con APF de DM2 (36: 21,2 % y una significación de p = 0,043. Concluimos que los sujetos con APF de DM2 son más propensos a tener hiperinsulinemia, al síndrome metabólico, a factores de riesgo cardiovascular y a lesión de órgano diana en comparación con los que no tienen dicho antecedente.A cross-sectional descriptive study of 340 persons assigned to two groups, with and without family history of diabetes mellitus type 2 (DM2, was carried out. The objective was to detect whether those persons with family history of DM2 had more hyperinsulemia, metabolic syndrome, associated cardiovascular risk factors and target organ lesions, expressed in left ventricle hypertrophy, than subjects without diabetes family history. The result was that hyperinsulemia was present in 96 patients with family history of DM2 (56,5 % and significance level of p= 0,001. Metabolic syndrome was more

  6. Captación de participantes en el programa experimental de prescripción de estupefacientes en Andalucía (PEPSA The experimental drug prescription program in Andalusia (PEPSA: procedure for recruiting participants

    Directory of Open Access Journals (Sweden)

    Joan Carles March

    2004-06-01

    Full Text Available Esta nota tiene como finalidad describir los pasos seguidos en el proceso de captación de los participantes en el ensayo andaluz de prescripción de heroína intravenosa. El programa experimental de prescripción de estupefacientes en Andalucía (PEPSA compara el tratamiento de heroína respecto a la metadona oral, en la mejoría de la salud física y mental y la integración social. Dada las características de la población diana (usuarios de heroína por vía intravenosa en situación de exclusión social para quienes no han sido efectivos los tratamientos disponibles, se planificó un abordaje específico para acercar dichas personas al estudio. Tras una investigación previa sobre la distribución de la población diana en la ciudad de Granada, se dividió ésta en 3 zonas. Se acudía a los principales centros de reunión (plazas, comedores sociales, dispensarios de metadona y se concretaba una cita con un médico del PEPSA. El trabajo apoyado en iguales ha sido una herramienta fundamental en este proceso de captación, y ha facilitado el acercamiento a la población diana. Asimismo, este trabajo ha permitido entablar contacto con usuarios de drogas que no acceden a los servicios sociosanitarios, por lo que la labor del equipo de captación también ha sido educar en la reducción de daños y ofrecer alternativas sociales y sanitarias más allá del ensayo.In this field note we describe the steps followed in the process of recruiting participants for the experimental drug prescription program in Andalusia (PEPSA. This trial is a comparative, randomized, open study of the difference between intravenous heroin treatment and oral methadone for socially excluded, opiate-dependent patients, in whom other available treatments have been unsuccessful. Because this is a hidden and hard-to-reach population, a specific approach was planned to put as many patients as possible in touch with the program. A previous study of the target population

  7. Biomoléculas interactivas a escala humana

    Directory of Open Access Journals (Sweden)

    José C. Diez

    2013-11-01

    Full Text Available En el proyecto “MolecularPlayground @ UAH.es” se ha instalado una exposición que muestra modelos de diferentes estructuras moleculares de forma programada, en un espacio de acceso común dentro de una facultad. Los estudiantes –y visitantes– pueden controlar la rotación del modelo proyectado moviéndose frente a la pantalla o moviendo sus manos, lo que proporciona interactividad y permite, en cierta medida, la manipulación de la imagen para el análisis e investigación de la estructura. Por ejemplo, el control de la molécula permite analizar los sitios de interacción con receptores u otras dianas, o considerar las fuerzas que definen las interacciones intermoleculares. Cada modelo se presenta de acuerdo a un guión, con diferentes vistas y estilos de representación de la molécula, combinados con breves textos explicativos de su relevancia y enfocando los aspectos notables de la estructura. Los objetivos pueden resumirse en: - Atraer la atención de los alumnos, la comunidad universitaria y el público en general hacia la estructura de las moléculas y su aplicación en campos de interés general: salud, industria, materiales... - Promover, especialmente en los alumnos, el interés por la investigación y la exploración personales. - Promover el análisis de las estructuras de interés bioquímico y farmacológico en la interacción con sus dianas. - Complementar la docencia y el estudio de las ciencias moleculares con materiales multimedia, de comprensión más rápida y eficaz. Proporcionar a los profesores un formato y un medio de difusión de material relacionado con sus asignaturas. Proporcionar a los alumnos material y actividades para el trabajo no presencial.   El proyecto se ha instalado con financiación de la Universidad de Alcalá, proyecto de innovación docente UAH/EV493.

  8. Cómo elaborar Guías de Recomendaciones de Autocuidado para Pacientes y Cuidadores (GRAPyC

    Directory of Open Access Journals (Sweden)

    Sandra Milena Hernández Zambrano

    2015-12-01

    Full Text Available Objetivo: Obtener una estructura estandarizada para la elaboración y publicación de Guías de Recomendaciones de Autocuidado para Pacientes y Cuidadores siguiendo la metodología de la Investigación Acción Participativa. Metodología: La guía se elabora a partir de tres etapas: Emergencia, Interacción y Modelización. En la emergencia, se identifica y analiza el problema principal que afecta a la población diana, se conforma el equipo elaborador, y se realiza una búsqueda de literatura científica que dé respuesta al problema. En la interacción, se establece un diálogo de saberes entre profesionales y ciudadanos para analizar y seleccionar aquellas recomendaciones que se consideran prioritarias para la población diana; se adaptan al nivel de comprensión y entorno cultural de pacientes o cuidadores y se implementan con el objetivo de evaluar su efectividad. Finalmente, en la modelización, se elabora el documento final, considerando tres elementos: diseño de la guía, contenidos y estructura. Estructura de la guía de recomendaciones: El formato establecido consta de 7 apartados: presentación del documento, información general del problema objeto de la guía, recomendaciones por temáticas, recursos web para pacientes y cuidadores, autores e instituciones que participaron en la elaboración y bibliografía. Utilidad esperada: La información contenida en estas guías se ajustada al lenguaje de los ciudadanos, es rigurosa pero fácil de comprender y favorece la toma de decisiones a partir de las mejores evidencias disponibles. Para las enfermeras clínicas se convierte en un instrumento novedoso orientado al diseño de materiales educativos basados en la evidencia científica.

  9. Genoma de Candida albicans y resistencia a las drogas

    Directory of Open Access Journals (Sweden)

    Sandra Cruz Quintana

    2017-01-01

    Full Text Available Candida albicans es un importante patógeno fúngico en los humanos tanto por su importan - cia clínica como por su uso como un modelo experimental para la investigación científica. La comprensión de la biología de este patógeno es un requisito importante para la identificación de nuevas dianas de medicamentos para la terapia antifúngica. En esta revisión nos proponemos profundizar en las características del genoma de Candida albicans, su relación con la virulen - cia y cómo influye en la resistencia a las drogas antifùngicas, que nos permita comprender los mecanismos por los cuales ejerce su acción patógena y desarrollar otros enfoques en la búsqueda de nuevos antifúngicos. La revisión se realizó a través de los buscadores y plataformas HINARI , SciELO y MEDLINE . Se revisaron 40 revistas de impacto de la Web of Science relacionadas con el tema. Los descriptores empleados fueron: “genome of Candida albicans”, “drug resistance genes”, “dimorphism”, “virulence” y la combinación entre ellos y sus equivalentes en español. El análisis de los genomas fúngicos hace posible predecir el rol de genes con potencial terapéu - tico, con la secuenciación del genoma de Candida albicans ha aumentado la información sobre la función de los genes, entre los que destacan los posibles objetivos farmacológicos. El estudio del genoma de Candida albicans resulta imprescindible para diseñar en el futuro protocolos diagnósticos seguros, así como hallar nuevas dianas antifúngicas que permitan formular te - rapias más efectivas.

  10. "Batallas contra la Lepra: Estado, Medicina y Ciencia en Colombia"

    Directory of Open Access Journals (Sweden)

    Carlos Lleras de la Fuente

    2003-03-01

    Full Text Available

    Hace pocos meses tuve el gusto de conocer a Diana Obregón Torres, de quien ya había oído hablar con ocasión de haber ella ganado el premio de Ciencias Sociales y Humanas de la Fundación
    Alejandro Ángel Escobar y de un reportaje que una amiga de mi hija le había hecho.
    Se me presentó en algún evento al cual ambos habíamos concurrido y tuve de ella una primera impresión equivocada: la de una persona suave, estudíosa, de bajo perfíl. Es este tipo de errores que
    lleva a que se desbaraten tantos matrimonios.
    La verdadera Diana es una investigadora rigurosa, erudita, disciplinada, que emite sus opiniones sobre todo y todos sin recato alguno y con una dureza que en muchos casos resulta urticante.
    Esa figura surgió del magnífico libro que el Fondo Editorial Universitario Eafit y el Banco de la República editaron en julio de este año, y cuyas 378 págínas de texto apasionante leí en un par de días, sin contar el vistazo que dí a las 37 páginas de la bibliografía las cuales, además y en notas de pie de página, respaldan la seriedad de su investigación.
    La lectura del líbro es, para un devorad'or de novelas de espionaje, de terror y policiacas, una triple ración de ese suspenso que, ya cerca del amanecer, no nos deja parar. Todos los elementos están en él
    presentes: el criminal es la lepra, que nos transporta al antíguo y al nuevo testamento; ha estado causando terror por varios milenios y nadie ha podido encarcelarla ni, por supuesto, aplicarle la tan desacreditada pena de muerte.
    Hoy día sigue tan campante y de vez en cuando se hace sentír desafíando las sulfonas y el aceite de chaulmugra. Es una enfermedad infecciosa, sin duda, pero el bacilo llamado "de Hansen" se ha defendido con éxito de los bacteriólogos quienes no han logrado producir la vacuna que permitiría erradicar este mal de la faz de la tierra...

  11. Reestenosis de la arteria coronaria descendente anterior en mujeres diabéticas

    Directory of Open Access Journals (Sweden)

    Franklin E. Choles

    2016-11-01

    Full Text Available Las mujeres diabéticas con la enfermedad arterial coronaria sometidas a revascularización tienen mayor riesgo de reestenosis debido a las alteraciones fisiopatológicas a nivel vascular propias de la diabetes, a la disminución del efecto protector de los estrógenos después de la menopausia y porque el calibre de sus arterias es menor que el de las no diabéticas y menor que el de los hombres. El objetivo de este artículo es comparar la tasa de reestenosis en la arteria coronaria descendente anterior en las mujeres diabéticas que se sometieron a intervención coronaria percutánea más el stent, frente a la cirugía de revascularización. Para ello se realizó una revisión de la literatura utilizando artículos publicados en bases de datos científicas, que compararan las dos técnicas, haciendo énfasis en la población diabética femenina. Encontrando que hubo una ventaja de la cirugía de revascularización sobre la intervención coronaria percutánea en los eventos de revascularización de la lesión diana (OR 0,253, IC 95% 0,092-0,703, p = 0,008 y revascularización del vaso diana (OR 0,185, 95% CI 0,079 a 0,432, p < 0,001, correspondiente a una ventaja en la presentación de evento cardiovascular y cerebrovascular (OR 0,429, CI 95% 0,254-0,723, p = 0,001. Finalmente, se hizo un análisis crítico, concluyendo que la cirugía de revascularización es la técnica de elección en las pacientes diabéticas puesto que tiene una tasa de reestenosis menor y con ello menos eventos adversos que de esta se derivan.

  12. A questão do banimento internacional das minas terrestres: novos atores na segurança internacional e os casos das Américas Central e do Sul The international ban on landmines: new actors in international security and the cases of Central America and South America

    Directory of Open Access Journals (Sweden)

    James Augusto Pires Tibúrcio

    2011-12-01

    Full Text Available O principal instrumento jurídico internacional destinado a banir o uso, a produção e as transferências internacionais de minas terrestres antipessoais é o Tratado de Ottawa, aprovado em 1997 e que, em junho de 2011, possuía 156 Estados signatários. No processo que conduziu à sua aprovação, diversas organizações da sociedade civil, em vários países, desempenharam papel de destaque por meio de uma forte pressão exercida sobre alguns governos nacionais, promovendo uma campanha de amplo impacto midiático e que obteve apoio de algumas celebridades, especialmente de Diana, princesa de Gales. O presente artigo tem como objetivo discutir a questão do banimento das minas terrestres antipessoais a partir dessa perspectiva, demonstrando que, em alguns temas com consequências humanitárias negativas muito evidentes, é possível que os governos reajam positivamente às pressões da sociedade civil. Ademais, também se analisa como o problema das minas terrestres antipessoais foi enfrentado na América Central e na América do Sul, destacando-se, ainda, o papel do Brasil no apoio às ações de desminagem nestas regiões.The main international legal instrument for banning the use, production and international transfers of antipersonnel landmines is the Ottawa Treaty, approved in 1997, which in June 2011 had 156 signatory states. In the process leading to its approval, several civil society organizations, in many countries, played a prominent role through heavy pressure on some governments, promoting a campaign of huge media impact with support from some celebrities, notably Diana, Princess of Wales. This paper shows that in some areas with very obvious negative humanitarian consequences, it is possible that governments react positively to civil society pressures. Furthermore, this paper also examines how the problem of antipersonnel landmines has been tackled in Central and South America, also touching on Brazil's role in supporting the

  13. Global health care leadership development: trends to consider

    Directory of Open Access Journals (Sweden)

    MacPhee M

    2013-06-01

    Full Text Available Maura MacPhee,1 Lilu Chang,2 Diana Lee,3 Wilza Spiri4 1University of British Columbia School of Nursing, Vancouver, British Columbia, Canada; 2Center for Advancement of Nursing Education, Koo Foundation, Sun Yat-Sen Cancer Center, Taipei, Taiwan; 3Nethersole School of Nursing, Chinese University of Hong Kong, Hong Kong, 4São Paulo State University, Botucatu, São Paulo, Brazil Abstract: This paper provides an overview of trends associated with global health care leadership development. Accompanying these trends are propositions based on current available evidence. These testable propositions should be considered when designing, implementing, and evaluating global health care leadership development models and programs. One particular leadership development model, a multilevel identity model, is presented as a potential model to use for leadership development. Other, complementary approaches, such as positive psychology and empowerment strategies, are discussed in relation to leadership identity formation. Specific issues related to global leadership are reviewed, including cultural intelligence and global mindset. An example is given of a nurse leadership development model that has been empirically tested in Canada. Through formal practice–academic–community collaborations, this model has been locally adapted and is being used for nurse leader training in Hong Kong, Taiwan, and Brazil. Collaborative work is under way to adapt the model for interprofessional health care leadership development. Keywords: health care leadership, development models, global trends, collective

  14. Observations of lightning in convective supercells within tropical storms and hurricanes

    Science.gov (United States)

    Lyons, Walter A.; Keen, Cecil S.

    1994-01-01

    Cloud-to-ground (CG) lightning observations from land-based lightning detection networks now allow monitoring this component of the electrical structure of tropical storms and hurricanes within a few hundred kilometers of the United States coastline. Several case studies confirm the long-held opinion that lightning is rather common within the outer rainbands. The general absence of CG lightning within the interior of mature tropical cyclones is also apparent. On the other hand, bursts of CG lightning near the circulation center of developing storms appear to precede periods of further deepening. The CG events are associated with convective supercells, whose anvil canopies can often obscure much of the underlying storm. Near-eyewall CG bursts preceding periods of intensification were noted in Hurricanes Diana (1984) and Florence (1988). A detailed case study of the 1987 unnamed tropical storm that struck the Texas-Louisiana coastline reveals that lightning was associated with two large supercells. These supercells appeared to be the trigger for the development of a closed circulation that formed several hours after the apparent low pressure center made landfall. Further studies of lightning may provide additional insight into the role of convective supercells in tropical storm intensification. It may also provide a useful diagnostic of impending deepening.

  15. Metabolite profiling of sesquiterpene lactones from Lactuca species. Major latex components are novel oxalate and sulfate conjugates of lactucin and its derivatives.

    Science.gov (United States)

    Sessa, R A; Bennett, M H; Lewis, M J; Mansfield, J W; Beale, M H

    2000-09-01

    Wounding leaves or stems of Lactuca species releases a milky latex onto the plant surface. We have examined the constituents of latex from Lactuca sativa (lettuce) cv. Diana. The major components were shown to be novel 15-oxalyl and 8-sulfate conjugates of the guaianolide sesquiterpene lactones, lactucin, deoxylactucin, and lactucopicrin. The oxalates were unstable, reverting to the parent sesquiterpene lactone on hydrolysis. Oxalyl derivatives have been reported rarely from natural sources. The sulfates were stable and are the first reported sesquiterpene sulfates from plants. Unusual tannins based on 4-hydroxyphenylacetyl conjugates of glucose were also identified. Significant qualitative and quantitative variation was found in sesquiterpene lactone profiles in different lettuce varieties and in other Lactuca spp. The proportions of each conjugate in latex also changed depending on the stage of plant development. A similar profile was found in chicory, in which oxalyl conjugates were identified, but the 8-sulfate conjugates were notably absent. The presence of the constitutive sesquiterpene lactones was not correlated with resistance to pathogens but may have a significant bearing on the molecular basis of the bitter taste of lettuce and related species. The induced sesquiterpene lactone phytoalexin, lettucenin A, was found in the Lactuca spp. but not in chicory.

  16. Thinking in systems a primer

    CERN Document Server

    Meadows, Donella H

    2008-01-01

    In the years following her role as the lead author of the international bestseller, "Limits to Growth"-the first book to show the consequences of unchecked growth on a finite planet- Donella Meadows remained a pioneer of environmental and social analysis until her untimely death in 2001. Meadows' newly released manuscript, "Thinking in Systems", is a concise and crucial book offering insight for problem solving on scales ranging from the personal to the global. Edited by the Sustainability Institute's Diana Wright, this essential primer brings systems thinking out of the realm of computers and equations and into the tangible world, showing readers how to develop the systems-thinking skills that thought leaders across the globe consider critical for 21st-century life. Some of the biggest problems facing the world-war, hunger, poverty, and environmental degradation-are essentially system failures. They cannot be solved by fixing one piece in isolation from the others, because even seemingly minor details have e...

  17. Picasso Paintings, Moon Rocks, and Hand-Written Beatles Lyrics: Adults’ Evaluations of Authentic Objects

    Science.gov (United States)

    Frazier, Brandy N.; Gelman, Susan A.; Wilson, Alice; Hood, Bruce

    2010-01-01

    Authentic objects are those that have an historical link to a person, event, time, or place of some significance (e.g., original Picasso painting; gown worn by Princess Diana; your favorite baby blanket). The current study examines everyday beliefs about authentic objects, with three primary goals: to determine the scope of adults’ evaluation of authentic objects, to examine such evaluation in two distinct cultural settings, and to determine whether a person’s attachment history (i.e., whether or not they owned an attachment object as a child) predicts evaluation of authentic objects. We found that college students in the U.K. (N = 125) and U.S. (N = 119) consistently evaluate a broad range of authentic items as more valuable than matched control (inauthentic) objects, more desirable to keep, and more desirable to touch, though only non-personal authentic items were judged to be more appropriate for display in a museum. These patterns were remarkably similar across the two cultural contexts. Additionally, those who had an attachment object as a child evaluated objects more favorably, and in particular judged authentic objects to be more valuable. Altogether, these results demonstrate broad endorsement of "positive contagion" among college-educated adults. PMID:20631919

  18. Prevalencia de la incontinencia urinaria en personas mayores de 64 años en Galicia

    Directory of Open Access Journals (Sweden)

    Dios-Diz J.M.

    2003-01-01

    Full Text Available Objetivo: Conocer la prevalencia de la incontinencia urinaria en Galicia en personas mayores de 64 años. Métodos: Se trata de un estudio descriptivo, basado en una encuesta personal a cada una de las personas de la muestra de la población diana. Ésta se obtuvo mediante un muestreo aleatorio estratificado en ámbito urbano, semiurbano y rural, en el conjunto de la comunidad de Galicia y, posteriormente, extrayendo una muestra al azar de la base de datos de la Tarjeta Individual Sanitaria de las localidades preseleccionadas. En total se obtuvieron 350 encuestas en 12 puntos de muestreo. Resultados: La prevalencia de la incontinencia urinaria en Galicia en el año 2002 es del 35,1% (intervalo de confianza del 95%, 31-38; 15-28 en varones y 38-51 en mujeres. Conclusiones: Uno de cada tres gallegos mayores de 64 años presenta incontinencia urinaria, siendo la prevalencia casi el doble en las mujeres.

  19. In Situ Boundary Layer Coral Metabolism in the Atlantic Ocean Acidification Test Bed

    Science.gov (United States)

    McGillis, Wade

    2013-04-01

    and Chris Langdon, Brice Loose, Dwight Gledhill, Diana Hsueh, Derek Manzello, Ian Enochs, Ryan Moyer We present net ecosystem productivity (nep) and net ecosystem calcification (nec) in coral and seagrass ecosystems using the boundary layer gradient flux technique (CROSS). Coastal anthropogenic inputs and changes in global ocean chemistry in response to rising levels of atmospheric carbon dioxide has emerged in recent years as a topic of considerable concern. Coral reefs are particularly vulnerable from eroded environmental conditions including ocean acidification and water pollution. The Atlantic Ocean Acidification Testbed (AOAT) project monitors metabolism to ascertain the continuing health of coral reef ecosystems. The CROSS boundary layer nep/nec approach is one component of this diagnostic program. Certification of CROSS as an operational monitoring tool is underway in the AOAT. CROSS inspects a benthic community and measures productivity/respiration and calcification/dissolution over an area of 10 square meters. Being a boundary layer tool, advection and complex mesoscale flows are not a factor or concern and CROSS is autonomous and can be used at deep benthic sites. The interrogation area is not enclosed therefore exposed to ambient light, flow, and nutrient levels. CROSS is easy to deploy, unambiguous, and affordable. Repeated measurements have been made from 2011-2012 in reefal systems in La Parguera Puerto Rico and the Florida Keys, USA. Diurnal, seasonal and regional metabolism will be compared and discussed. The ability to accurately probe benthic ecosystems provides a powerful management and research tool to policy makers and researchers.

  20. The Sacred Mountain of Varallo in Italy: seismic risk assessment by acoustic emission and structural numerical models.

    Science.gov (United States)

    Carpinteri, Alberto; Lacidogna, Giuseppe; Invernizzi, Stefano; Accornero, Federico

    2013-01-01

    We examine an application of Acoustic Emission (AE) technique for a probabilistic analysis in time and space of earthquakes, in order to preserve the valuable Italian Renaissance Architectural Complex named "The Sacred Mountain of Varallo." Among the forty-five chapels of the Renaissance Complex, the structure of the Chapel XVII is of particular concern due to its uncertain structural condition and due to the level of stress caused by the regional seismicity. Therefore, lifetime assessment, taking into account the evolution of damage phenomena, is necessary to preserve the reliability and safety of this masterpiece of cultural heritage. A continuous AE monitoring was performed to assess the structural behavior of the Chapel. During the monitoring period, a correlation between peaks of AE activity in the masonry of the "Sacred Mountain of Varallo" and regional seismicity was found. Although the two phenomena take place on very different scales, the AE in materials and the earthquakes in Earth's crust, belong to the same class of invariance. In addition, an accurate finite element model, performed with DIANA finite element code, is presented to describe the dynamic behavior of Chapel XVII structure, confirming visual and instrumental inspections of regional seismic effects.

  1. The Sacred Mountain of Varallo in Italy: Seismic Risk Assessment by Acoustic Emission and Structural Numerical Models

    Directory of Open Access Journals (Sweden)

    Alberto Carpinteri

    2013-01-01

    Full Text Available We examine an application of Acoustic Emission (AE technique for a probabilistic analysis in time and space of earthquakes, in order to preserve the valuable Italian Renaissance Architectural Complex named “The Sacred Mountain of Varallo.” Among the forty-five chapels of the Renaissance Complex, the structure of the Chapel XVII is of particular concern due to its uncertain structural condition and due to the level of stress caused by the regional seismicity. Therefore, lifetime assessment, taking into account the evolution of damage phenomena, is necessary to preserve the reliability and safety of this masterpiece of cultural heritage. A continuous AE monitoring was performed to assess the structural behavior of the Chapel. During the monitoring period, a correlation between peaks of AE activity in the masonry of the “Sacred Mountain of Varallo” and regional seismicity was found. Although the two phenomena take place on very different scales, the AE in materials and the earthquakes in Earth’s crust, belong to the same class of invariance. In addition, an accurate finite element model, performed with DIANA finite element code, is presented to describe the dynamic behavior of Chapel XVII structure, confirming visual and instrumental inspections of regional seismic effects.

  2. Pharmaceuticals, alkylphenols and pesticides in Mediterranean coastal waters: Results from a pilot survey using passive samplers

    Science.gov (United States)

    Munaron, Dominique; Tapie, Nathalie; Budzinski, Hélène; Andral, Bruno; Gonzalez, Jean-Louis

    2012-12-01

    21 pharmaceuticals, 6 alkylphenols and 27 hydrophilic pesticides and biocides were investigated using polar organic contaminant integrative samplers (POCIS) during a large-scale study of contamination of French Mediterranean coastal waters. Marine and transitional water-bodies, defined under the EU Water Framework Directive were monitored. Our results show that the French Mediterranean coastal waters were contaminated with a large range of emerging contaminants, detected at low concentrations during the summer season. Caffeine, carbamazepine, theophilline and terbutaline were detected with a detection frequency higher than 83% in the coastal waters sampled, 4-nonylphenol (4-NP), 4-tert-octylphenol (4-OP) and 4-nonylphenol diethoxylate (NP2EO) were detected in all coastal waters sampled, and diuron, terbuthylazine, atrazine, irgarol and simazine were detected in more than 77% of samples. For pharmaceuticals, highest time-weighted average (TWA) concentrations were measured for caffeine and carbamazepine (32 and 12 ng L-1, respectively). For alkylphenols, highest TWA concentrations were measured for 4-nonylphenol mono-ethoxylate and 4-nonylphenol (41 and 33 ng L-1, respectively), and for herbicides and biocides, they were measured for diuron and irgarol (33 and 2.5 ng L-1, respectively). Except for Diana lagoon, lagoons and semi-enclosed bays were the most contaminated areas for herbicides and pharmaceuticals, whilst, for alkylphenols, levels of contamination were similar in lagoons and coastal waters. This study demonstrates the relevance and utility of POCIS as quantitative tool for measuring low concentrations of emerging contaminants in marine waters.

  3. ERP correlates of source memory: unitized source information increases familiarity-based retrieval.

    Science.gov (United States)

    Diana, Rachel A; Van den Boom, Wijnand; Yonelinas, Andrew P; Ranganath, Charan

    2011-01-07

    Source memory tests typically require subjects to make decisions about the context in which an item was encoded and are thought to depend on recollection of details from the study episode. Although it is generally believed that familiarity does not contribute to source memory, recent behavioral studies have suggested that familiarity may also support source recognition when item and source information are integrated, or "unitized," during study (Diana, Yonelinas, and Ranganath, 2008). However, an alternative explanation of these behavioral findings is that unitization affects the manner in which recollection contributes to performance, rather than increasing familiarity-based source memory. To discriminate between these possibilities, we conducted an event-related potential (ERP) study testing the hypothesis that unitization increases the contribution of familiarity to source recognition. Participants studied associations between words and background colors using tasks that either encouraged or discouraged unitization. ERPs were recorded during a source memory test for background color. The results revealed two distinct neural correlates of source recognition: a frontally distributed positivity that was associated with familiarity-based source memory in the high-unitization condition only and a parietally distributed positivity that was associated with recollection-based source memory in both the high- and low-unitization conditions. The ERP and behavioral findings provide converging evidence for the idea that familiarity can contribute to source recognition, particularly when source information is encoded as an item detail. Copyright © 2010 Elsevier B.V. All rights reserved.

  4. Management of neovascular age-related macular degeneration: current state-of-the-art care for optimizing visual outcomes and therapies in development

    Directory of Open Access Journals (Sweden)

    Agarwal A

    2015-06-01

    Full Text Available Aniruddha Agarwal, William R Rhoades, Mostafa Hanout, Mohamed Kamel Soliman, Salman Sarwar, Mohammad Ali Sadiq, Yasir Jamal Sepah, Diana V Do, Quan Dong Nguyen Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA Abstract: Contemporary management of neovascular age-related macular degeneration (AMD has evolved significantly over the last few years. The goal of treatment is shifting from merely salvaging vision to maintaining a high quality of life. There have been significant breakthroughs in the identification of viable drug targets and gene therapies. Imaging tools with near-histological precision have enhanced our knowledge about pathophysiological mechanisms that play a role in vision loss due to AMD. Visual, social, and vocational rehabilitation are all important treatment goals. In this review, evidence from landmark clinical trials is summarized to elucidate the optimum modern-day management of neovascular AMD. Therapeutic strategies currently under development, such as gene therapy and personalized medicine, are also described. Keywords: AMD, neovascular AMD, choroidal neovascular membrane, pharmacogenomics, VEGF, low-vision rehabilitation, gene therapy

  5. Evaluadores de este Número

    Directory of Open Access Journals (Sweden)

    Comité Editorial

    2017-03-01

    Full Text Available Evaluadores NacionalesMagdalena Arnao, Universidad Nacional de CórdobaMaría Gabriela Chaparro, Universidad Nacional del Centro de la Pcia. de Buenos AiresEmilio Crenzel, Universidad de Buenos AiresDaniel Feierstein, Universidad Nacional de Tres de FebreroAna María Gorosito Kramer, Universidad Nacional de MisionesAnne Gustavsson, Universidad Nacional de San MartínPaula Silvana Novellino, Museo de Ciencias Naturales y Antropológicas Juan Cornelio MoyanoNatalia Ojeda, Universidad Nacional del Centro de la Pcia. de Buenos AiresFrancisco Pazzarelli, Universidad Nacional de CórdobaJaime Peire, Universidad Nacional de Tres de FebreroAna Ramos, Universidad Nacional de Río NegroAgustina Rodríguez Romero, Universidad Nacional de Tres de FebreroCarlos Salamanca, Flacso – Argentina.Jorge Suby, Universidad Nacional del Centro de la Pcia. de Buenos AiresEvaluadores Extranjeros  Karina Biondi, Universidade Estadual de Campinas, BrasilVincent Hirtzel, Centre National de la Recherche Scientifique – CNRS, FranciaMaría Isabel Jociles Rubio, Universidad Compultense de Madrid, EspañaLiuba Kogan, Universidad del Pacífico, PerúDiana Marre, Universidad Autónoma de Barcelona, EspañaMario Ruffer, Universidad Autónoma Metropolitana, México

  6. Immunotherapy for the treatment of Alzheimer's disease: amyloid-β or tau, which is the right target?

    Directory of Open Access Journals (Sweden)

    Castillo-Carranza DL

    2013-12-01

    Full Text Available Diana L Castillo-Carranza,1,2 Marcos J Guerrero-Muñoz,1,2 Rakez Kayed1–31Mitchell Center for Neurodegenerative Diseases, 2Departments of Neurology, Neuroscience, and Cell Biology, 3Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX, USAAbstract: Alzheimer's disease (AD is characterized by the presence of amyloid plaques composed mainly of amyloid-β (Aβ protein. Overproduction or slow clearance of Aβ initiates a cascade of pathologic events that may lead to formation of neurofibrillary tangles, neuronal cell death, and dementia. Although immunotherapy in animal models has been demonstrated to be successful at removing plaques or prefibrillar forms of Aβ, clinical trials have yielded disappointing results. The lack of substantial cognitive improvement obtained by targeting Aβ raises the question of whether or not this is the correct target. Another important pathologic process in the AD brain is tau aggregation, which seems to become independent once initiated. Recent studies targeting tau in AD mouse models have displayed evidence of cognitive improvement, providing a novel therapeutic approach for the treatment of AD. In this review, we describe new advances in immunotherapy targeting Aβ peptide and tau protein, as well as future directions.Keywords: immunotherapy, Alzheimer's disease, β-amyloid, tau

  7. Devices for continuous monitoring of glucose: update in technology

    Directory of Open Access Journals (Sweden)

    Gómez AM

    2017-09-01

    Full Text Available Ana María Gómez,1 Diana Cristina Henao Carrillo,1 Oscar Mauricio Muñoz Velandia2,3 1Endocrinology Unit, Hospital Universitario San Ignacio, Bogotá, Colombia; 2Department of Internal Medicine, Hospital Universitario San Ignacio, Bogotá, Colombia; 3Department of Clinical Epidemiology, Pontificia Universidad Javeriana, Faculty of Medicine, Bogotá, Colombia Abstract: Continuous glucose monitoring (CGM is a tool that allows constant evaluation of glycemic control, providing data such as the trend and fluctuation of interstitial glucose levels over time. In clinical practice, there are two modalities: the professional or retrospective and the personal or real-time CGM (RT-CGM. The latest-generation sensors are more accurate and sensitive for hypoglycemia, improving adherence to self-monitoring, which has allowed optimizing glycemic control. The development of algorithms that allow the suspension of the infusion of insulin during hypoglycemia gave rise to the integrated therapy or sensor-augmented insulin pump therapy with low glucose suspend, which has proven to be an effective and safe alternative in the treatment of diabetic patients with high risk of hypoglycemia. The objective of this review is to present the evidence of the advantages of RT-CGM, the clinical impact of integrated therapy, and cost-effectiveness of its implementation in the treatment of patients with diabetes mellitus. Keywords: CMG, devices, hypoglycemia, SAPT, SAPT+LGS

  8. Effect of Large Negative Phase of Blast Loading on Structural Response of RC Elements

    Directory of Open Access Journals (Sweden)

    Syed Zubair Iman

    2016-01-01

    Full Text Available Structural response of reinforced concrete (RC elements for analysis and design are often obtained using the positive phase of the blast pressure curve disregarding the negative phase assuming insignificant contribution from the negative phase of the loading. Although, some insight on the effect of negative phase of blast pressure based on elastic single-degree-of-freedom (SDOF analysis was presented before, the influence of negative phase on different types of resistance functions of SDOF models and on realistic finite element analysis has not been explored. In this study, the effects of inclusion of pulse negative phase on structural response of RC elements from SDOF analysis and from more detailed finite element analysis have been investigated. Investigation of SDOF part has been conducted using MATLAB code that utilizes non-linear resistance functions of SDOF model. Detailed numerical investigation using finite element code DIANA was conducted on the significance of the negative phase on structural response. In the FE model, different support stiffness was used to explore the effect of support stiffness on the structural response due to blast negative phase. Results from SDOF and FE analyses present specific situations where the effect of large negative phase was found to be significant on the structural response of RC elements.

  9. Cytomegaloviruses in a Community of Wild Nonhuman Primates in Taï National Park, Côte D’Ivoire

    Directory of Open Access Journals (Sweden)

    Augustin Etile Anoh

    2017-12-01

    Full Text Available Cytomegaloviruses (CMVs are known to infect many mammals, including a number of nonhuman primates (NHPs. However, most data available arose from studies led on captive individuals and little is known about CMV diversity in wild NHPs. Here, we analyzed a community of wild nonhuman primates (seven species in Taï National Park (TNP, Côte d’Ivoire, with two PCR systems targeting betaherpesviruses. CMV DNA was detected in 17/87 primates (4/7 species. Six novel CMVs were identified in sooty mangabeys, Campbell’s monkeys and Diana monkeys, respectively. In 3/17 positive individuals (from three NHP species, different CMVs were co-detected. A major part of the glycoprotein B coding sequences of the novel viruses was amplified and sequenced, and phylogenetic analyses were performed that included three previously discovered CMVs of western red colobus from TNP and published CMVs from other NHP species and geographic locations. We find that, despite this locally intensified sampling, NHP CMVs from TNP are completely host-specific, pinpointing the absence or rarity of cross-species transmission. We also show that on longer timescales the evolution of CMVs is characterized by frequent co-divergence with their hosts, although other processes, including lineage duplication and host switching, also have to be invoked to fully explain their evolutionary relationships.

  10. A microclimate study on hypogea environments of ancient roman building.

    Science.gov (United States)

    Scatigno, C; Gaudenzi, S; Sammartino, M P; Visco, G

    2016-10-01

    Roman hypogea, vernacular settlements or crypts, are underground places characterised by specific and unique challenges (RHRome-Italy), with the aim of characterising the indoor environment as the structure suffers of several conservation problems (biocolonisation, efflorescences, evaporating and condensing cycle for wall-building materials). The campaign involving multipoint continuous measurement was carefully planned to better describe this micro-clime. In addition to underground environmental data available in literature, we have also performed, as a checkpoint control, a thermo-hygrometric monitoring campaign in the "Terme di Mitra" Hypogeum, a few meters from the "Casa di Diana". The recorded data was analysed by multivariate statistical and chemometric analyses. The results brought to light the presence of different microclimates (three areas) within a single Mithraeum: a room (pre-Mithraeum) and an area (Mithraeum: 2-4m) present a thermo-hygrometric environmental behaviour in accordance with a semi-confined environment, another area (Mithraeum: 1-2m) behaves accordingly with underground environments (although it cannot be described as such), and the last area (Mithraeum: 0-1m) where was recording RH values close to saturation (96-99%), associated with non-ventilated areas where the rising damp is "held" and not dispersed, describing an own micro-clime, comparable to a "small greenhouse". This study has allowed to identify some critical areas in view of planning future conservation solutions, without exporting the artefacts kept inside. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. Fate of Escherichia coli O157:H7, Salmonella and Listeria innocua on minimally-processed peaches under different storage conditions.

    Science.gov (United States)

    Alegre, Isabel; Abadias, Maribel; Anguera, Marina; Usall, Josep; Viñas, Inmaculada

    2010-10-01

    Consumption of fresh-cut produce has sharply increased recently causing an increase of foodborne illnesses associated with these products. As generally, acidic fruits are considered 'safe' from a microbiological point of view, the aim of this work was to study the growth and survival of Escherichia coli O157:H7, Salmonella and Listeria innocua on minimally-processed peaches. The three foodborne pathogens population increased more than 2 log(10)units on fresh-cut peach when stored at 20 and 25 degrees C after 48 h. At 10 degrees C only L. innocua grew more than 1 log(10)unit and it was the only pathogen able to grow at 5 degrees C. Differences in growth occurred between different peach varieties tested, with higher population increases in those varieties with higher pH ('Royal Glory' 4.73+/-0.25 and 'Diana' 4.12+/-0.18). The use of common strategies on extending shelf life of fresh-cut produce, as modified atmosphere packaging and the use of the antioxidant substance, ascorbic acid (2%w/v), did not affect pathogens' growth at any of the temperatures tested (5 and 25 degrees C). Minimally-processed peaches have shown to be a good substrate for foodborne pathogens' growth regardless use of modified atmosphere and ascorbic acid. Therefore, maintaining cold chain and avoiding contamination is highly necessary. 2010 Elsevier Ltd. All rights reserved.

  12. Texto e têxtil em O Livro de Travesseiro

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    Andrei Cunha

    2015-12-01

    Full Text Available ABSTRACT: This text is a three-part reflection upon the theme of “clothing” as it is found in a literary work of Ancient Japan — on the importance of garment-making skills as a device for the production of difference in the context of the Imperial Court; on how the theme from the book resonates in the context of 20th century fashion; and on how it is brought up to date and amplified, working as a metaphor for writing, in the film adaptation of the ancient text. In The Pillow Book of Sei Shônagon (Japan, 10th–11th centuries, text, textile and memory merge into an extended, web-like metaphor that is also a commentary on the status of women in Imperial Heian. The adaptation of the written work for the cinema (The Pillow Book, by Peter Greenaway, 1996 features clothes by deconstructivist Martin Margiela, adding new interpretative layers to this cluster of images, relating them to the acts of writing, weaving, reading, translating, adapting and deconstructing. The fragmentary character of Sei Shônagon’s work also resonates with fashion journalism of the 20th century. The aesthetic ideal of okashi, a concept from classical Japanese literature, resonates with 20th century conceptions of fashion, such as Diana Vreeland’s pizzazz, and with the aesthetics of modernist poetry. Clothing as a metaphor for text and the idea of clothing as text are present in those three interpretative moments.

  13. Modelos para una santa. El necesario icono en la vida de Teresa de Ávila

    Directory of Open Access Journals (Sweden)

    Cea Gutiérrez, Antonio

    2006-06-01

    Full Text Available From the binomial consisting of cult images and devotional world, the author analyzes post-Tridentine personal spirituality in women’s convents of the 16th century. By looking into St. Theresa’s ascetico-mystical texts and extensive epistolary correspondence from an ethnoliterary perspective, the analyst can unveil the inside of this extraordinary woman and her social context. In her struggle for spiritual ascension, the Saint oscillated between austerity and hedonism, between privation and pleasure-seeking, between good and evil, holding Jesus Himself, Mary and the saints of her devotion as materialized target in the images of her.

    Desde el binomio imagen de culto y mundo devocional, se analiza el fenómeno de la espiritualidad personal, ya tridentino, en el espacio conventual femenino del siglo XVI. Bajo una perspectiva etnoliteraria y a través de los textos ascético-místicos de Teresa de Jesús y de su copiosa correspondencia epistolar, descubrimos el interior de esta extraordinaria mujer y su entorno social. En su lucha ascensional se debate la Santa entre la austeridad y el hedonismo, entre la privación y lo que le causa placer, entre el bien y el mal, teniendo al propio Cristo, a la Virgen y a los santos de su devoción como diana materializada en sus imágenes.

  14. La divulgación radiofónica de la alimentación y la higiene infantil en la España de la Segunda República (1933-1935

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    Josep Bernabeu Mestre

    2011-01-01

    Full Text Available El trabajo analiza la incorporación de medios tecnológicos, en particular la radio, en el proceso de divulgación del conocimiento sobre la salud infantil durante la Segunda República española. En el marco de la campaña sanitaria contra la mortalidad infantil que puso en marcha la Segunda República en la década del 30, la Asociación Española de Médicos Puericultores Titulados, en colaboración con Unión Radio, organizó dos ciclos de conferencias radiofónicas que pretendían explicar, a través de un discurso divulgativo de tono descriptivo dirigido a las clases populares, las nociones fundamentales de la higiene y la alimentación infantil, e impulsar una cultura de la prevención, guiada y orientada por los dictados de los expertos. Se trataba de una acción de propaganda y divulgación que tenía su continuidad en el medio familiar y comunitario a través de la actuación de las enfermeras visitadoras puericultoras, contemplando a las madres como población diana.

  15. Hubungan antara dukungan sosial dengan resiliensi yang dimoderatori oleh locus of control pada mahasiswa bidikmisi

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    Alaiya Choiril Mufidah

    2018-01-01

    Full Text Available Pendidikan merupakan hal yang sangat penting yang harus diberikan kepada semua orang di dunia, namun kadang berbagai alasan melatar belakangi individu tidak melanjutkan pendidikan pada jenjang yang lebih tinggi. Dan salah satu penyebab tidak melanjutkan pendidikan yakni masalah kurangnya biaya. Mahasiswa bidikmisi merupakan berlatar belakang dari mahasiswa yang mampu dalam segi akademik namun kurang mampu dalam segi ekonomi, sehingga mereka diberikan beasiswa oleh pemerintah untuk bisa melanjutkan ke jenjang pendidikan yang lebih tinggi. Penelitian ini bertujuan untuk mengetahui hubungan positif antara dukungan sosial dan resiliensi mahasiswa bidikmisi, untuk mengetahui hubungan positif antara locus of control dan resiliensi, dan untuk mengetahui hubungan positif antara dukungan social dan resiliensi dengan Locus of Control sebagai variabel moderator. Penelitian ini menggunakan metode kuantitatif dengan tehnik analisis regresi berganda. Skala Resiliensi adaptasi milik Connor & Davidson (CD-RISC, skala Locus of Control adaptasi milik Levinson (MLCS, dan skala Dukungan Sosial adaptasi tesis Diana Kamilin. Hubungan antara variabel X dan Y dengan LOC sebagai mediator. . Subjek penelitian adalah mahasiswa bidikmisi di UIN Malang sebanyak 80 subjek Hasil dari analisis menunjukkan bahwa terdapat hubungan yang positif antara dukungan social dan resiliensi dengan locus of control sebagai moderator dengan nilai signifikansi 0.431 (p

  16. La calidad de vida en personas con síndrome de intestino irritable

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    C. FERNÁNDEZ RODRÍGUEZ

    2002-01-01

    Full Text Available Se evalúa la calidad de vida en una muestra de 31 pacientes diagnosticados de SII con sintomatología mixta (dolor y alteración del hábito intestinal, de moderada intensidad y de curso crónico. Se indaga, mediante autoinfor - mes y cuestionarios estandarizados, las manifestaciones clinicas caracteristicas, la capacidad funcional, el estado emocional, el apoyo social, las conductas de enfermedad, el estado de salud y las limitaciones cotidianas. Los resultados, considerada la muestra en su conjunto, indican que el SII no empeora la calidad de vida. Los análisis correlacionales y de regresión logística señalan que son las peculiaridades comportamentales que definen este trastorn o antes que la sintomatología digestiva las condiciones más potentes para explicar la calidad de vida de los pacientes. El estado depresivo (HAD-D, las manifestaciones de enfermedad (Kellner, la apreciación de limitaciones coti - dianas (IBS-QOL, PSN y las molestias en relación a la deposición, hinchazón y fatiga son los parámetros que mayor y más significativa relación guard a n con una peor valoración de la calidad de vida en la muestra de estudio.

  17. ESTUDIOS DE PATOLOGÍA MOLECULAR UTILIZADOS PARA EVALUAR LA AMPLIFICACIÓN DEL ONCOGÉN HER2 EN CÁNCER DE MAMA. OPINIÓN CLÍNICA

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    Luz Fernanda Sua

    2014-12-01

    Full Text Available La importancia en la detección de la amplificación de oncogén HER2, es esencial en el cáncer de mama puesto que estas pacientes no responden a los tratamientos de quimioterapia y hormonales convencionales, traduciéndose así en una menor sobrevida. La determinación del oncogén HER2 tiene un papel crucial como diana terapéutica del trastuzumab. A continuación describiremos estas metodologías las cuales son: la técnica de hibridación in situ fluorescente (FISH, la hibridación in situ cromogénica (CISH y la técnica hibridación in situ cromogénica y con plata (Dual ISH, métodos usados para el estudio del oncogén HER2, en la selección correcta de las pacientes con cáncer de mama que son candidatas a recibir trastuzumab, teniendo una gran utilidad e impacto clínico. Palabras clave: Amplificación HER2, Hibridación in situ fluorescente (FISH, Hibridación in situ cromogénica (CISH e Hibridación in situ cromogénica y con plata (DISH.

  18. Laser thermal ablation of multidrug-resistant bacteria using functionalized gold nanoparticles

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    Mocan L

    2017-03-01

    Full Text Available Lucian Mocan,1,2 Flaviu A Tabaran,3 Teodora Mocan,2,4 Teodora Pop,5 Ofelia Mosteanu,5 Lucia Agoston-Coldea,6 Cristian T Matea,2 Diana Gonciar,2 Claudiu Zdrehus,1,2 Cornel Iancu1 13rd Department of General Surgery, “Iuliu Hatieganu” University of Medicine and Pharmacy, 2Department of Nanomedicine, “Octavian Fodor” Gastroenterology Institute, 3Department of Pathology, University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, 4Department of Physiology, 53rd Gastroenterology Department, 6Department of Internal Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania Abstract: The issue of multidrug resistance (MDR has become an increasing threat to public health. One alternative strategy against MDR bacteria would be to construct therapeutic vectors capable of physically damaging these microorganisms. Gold nanoparticles hold great promise for the development of such therapeutic agents, since the nanoparticles exhibit impressive properties, of which the most important is the ability to convert light into heat. This property has scientific significance since is exploited to develop nano-photothermal vectors to destroy bacteria at a molecular level. The present paper summarizes the latest advancements in the field of nanotargeted laser hyperthermia of MDR bacteria mediated by gold nanoparticles. Keywords: bacteria, photo-thermal ablation, gold nanoparticles, antibiotic resistance

  19. alles – einfach – sofort: Service in Medizinbibliotheken / all – simply – immediately: service in medical libraries

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    Bauer, Bruno

    2010-12-01

    Full Text Available The focus of the current issue 3/2010 of GMS Medizin – Bibliothek – Information is the annual conference 2010 of the German Medical Libraries Association in Mainz. The motto of the conference was “all – simply – immediately: service in medical libraries”. Focal points of the meeting were innovative services and products in medical libraries. Further speeches focused on new library buildings, blended-learning and quality management.The authors in this issue are Bruno Bauer, Daniel Formanek & Marian Miehl (Virtuelle Lehrbuchsammlung und E-Books-On-Demand als Facetten der Hybridbibliothek: zwei innovative Services der Universitätsbibliothek der Medizinischen Universität Wien, Markus Fischer, Stefan Kandera, Dieter Sulzer, Susanne Mayer, Maike Krone, Erika Niedermann & Veronika Kleibel (bibnet.org – kooperative Referenzdatenbank für das Gesundheitswesen, Franz Josef Kühnen (40 Jahre AGMB – Gründung und Anfänge, Oliver Obst (2. Zukunftskolloquium der Zweigbibliothek Medizin der Universität Münster, 28./29. Juni 2010, Manuela Schulz (Service vor Ort – Die Bibliothek geht zum Nutzer, Sabine Hoyer (Entdecken Sie die Bibliothek mit Rüdiger: ein virtueller Rundgang der etwas anderen Art durch die Fachbibliothek Medizin in Mainz, Eike Hentschel & Anja Kaiser (alles – einfach – sofort: Service in Medizinbibliotheken: Jahrestagung der Arbeitsgemeinschaft für Medizinisches Bibliothekswesen (AGMB e.V. vom 27. bis 29.9.2010 in Mainz: Tagungsbericht and Diana Klein (Aus der AGMB.

  20. Where we were in 1998, and how this legacy shaped the next 20 years

    Science.gov (United States)

    Moran, E. F.

    2017-12-01

    When the National Research Council Committee on Human Dimensions of Global Change decided to convene a gathering of social scientists and remote sensing researchers in 1997 we wanted to know the state-of-knowledge and particularly what challenges those who were beginning to make this linkage had found. Diana Liverman as Chair of the Committee invited Emilio Moran and Ronald Rindfuss from UNC to join her and Paul Stern, from NRC, to organize the meeting, and the resulting volume with support from NASA. In 1997 we were just getting started. Most of us at the meeting had just engaged remote sensing in the past 5 years or so, and each team invited had very different approaches to how to make this linkage (do all have to know and do RS? Or is there a clear division of labor between the social and the remote? The meeting and the intro and concluding chapter of People and Pixels provided a roadmap for the future. This paper will discuss which directions proved to be most significant in advancing this linkage, and what surprises have emerged along the way to advance the linking of remote sensing approaches with the questions that interest social science and the global environmental change community.

  1. Meeting report of the first conference of the International Placenta Stem Cell Society (IPLASS)

    Science.gov (United States)

    Parolini, O.; Alviano, F.; Betz, A.G.; Bianchi, D.W.; Götherström, C.; Manuelpillai, U.; Mellor, A.L.; Ofir, R.; Ponsaerts, P.; Scherjon, S.A.; Weiss, M.L.; Wolbank, S.; Wood, K.J.; Borlongan, C.V.

    2012-01-01

    The International Placenta Stem Cell Society (IPLASS) was founded in June 2010. Its goal is to serve as a network for advancing research and clinical applications of stem/progenitor cells isolated from human term placental tissues, including the amnio-chorionic fetal membranes and Wharton's jelly. The commitment of the Society to champion placenta as a stem cell source was realized with the inaugural meeting of IPLASS held in Brescia, Italy, in October 2010. Officially designated as an EMBO-endorsed scientific activity, international experts in the field gathered for a 3-day meeting, which commenced with “Meet with the experts” sessions, IPLASS member and board meetings, and welcome remarks by Dr. Ornella Parolini, President of IPLASS. The evening's highlight was a keynote plenary lecture by Dr. Diana Bianchi. The subsequent scientific program consisted of morning and afternoon oral and poster presentations, followed by social events. Both provided many opportunities for intellectual exchange among the 120 multi-national participants. This allowed a methodical and deliberate evaluation of the status of placental cells in research in regenerative and reparative medicine. The meeting concluded with Dr. Parolini summarizing the meeting's highlights. This further prepared the fertile ground on which to build the promising potential of placental cell research. The second IPLASS meeting will take place in September 2012 in Vienna, Austria. This meeting report summarizes the thought-provoking lectures delivered at the first meeting of IPLASS. PMID:21575989

  2. La infidelidad de los dioses: Lenguaje y simulacro en Pierre Klossowski

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    Rayiv David Torres Sanchez

    2018-01-01

    Full Text Available Pierre Klossowski se sirvió de la doctrina del eterno retorno de Nietzsche para poner en tela de juicio el principio de identidad tanto en la escritura como en el lenguaje; un falso principio que, como el Dios-Uno, simula ser único y verdadero. Así mismo, Klossowski se sirvió de la figura nietzscheana de la “muerte de Dios” para hablar del ocaso de la identidad, y poner en entredicho las certezas depositadas en la suficiencia y eficacia del lenguaje. A la luz de la filosofía de Klossowski se pondrá en evidencia cómo en su literatura y en su interpretación del mito del baño de Diana, asistimos a la caída del paradigma del principio de no contradicción, de lo que se deriva la posibilidad retórica del mundo devenido en fábula. Esto tendría lugar en el momento en que toda escritura estriba en el plano de la ficción, donde todos los simulacros, como ha dicho Gilles Deleuze comentando a Klossowski, ascienden a la superficie. El simulacro se convierte en fantasma.

  3. Reading Comprehension: A Viable Challenge for Public School Students

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    Correales Rocío

    2000-08-01

    Full Text Available This study was conducted in the Diana Turbay state school with students of one eighth grade class with a low English level. The group was chosen because of their special characteristics within this public institution: their number (just eighteen students and their interest in and motivation for learning English as a foreign language. The motivation they show allowed the researchers to observe and collect more specific information for this study and for future research on reading comprehension. Data collection was conducted using many different techniques, such as open observations, diary, surveys, students’ self-evaluation and field notes. All these techniques provided information as authentic as possible. The purpose of the study was to determine if students improved their reading comprehension in English by applying specific reading strategies. Results showed that students from state schools can achieve good comprehension of English texts through adequate training despite the fact that they start their English learning so late. Further research on this topic should study the relationship between reading comprehension in Spanish and in English. It would also be necessary to study how students can acquire language structures through reading activities.

  4. [The woman in neurosurgery at the national institute of neurology and neurosurgery].

    Science.gov (United States)

    Mejía-Pérez, Sonia Iliana; Cervera-Martínez, Claudia; Sánchez-Correa, Thalía Estefanía; Corona-Vázquezo, Teresa

    Women have always had a hard time in the history of medicine; Dr. Isabel Blackwell was the first woman in history to practice medicine. Dr. Diana Beck became the world´s first female neurosurgeon. The first Latin American female neurosurgeon was Dr. María Cristina García Sancho y Álvarez-Tostado. All of these women had to face a large number of social, cultural, and economic obstacles in their path; however, this situation has changed gradually. Dr. Ana Lilia Siordia Karam was the first neurosurgeon to graduate from INNN. Nineteen years later the second female neurosurgeon at this institute was Dr. María Petra Herrera Guerrero. During their time at this institute they endured a lot of difficulties, especially with most of their coworkers; however, some coworkers treated them with respect and no gender distinction. Nowadays, four of the 25 total neurosurgery residents at INNN are women, and even though some of them have had to endure acts of gender discrimination, the general situation has changed. With work and respect, women have managed to have a larger role in the surgical field. We hope that in the near future a gender discrimination-free environment will be achieved in medicine and its specialties.

  5. Keragaman Genetik Sekuen Gen ATP Synthase FO Subunit 6 (ATP6 Monyet Hantu (Tarsius Indonesia (GENETIC DIVERSITY STUDY OF ATP6 GENE SEQUENCES OF TARSIERS FROM INDONESIA

    Directory of Open Access Journals (Sweden)

    Rini Widayanti

    2013-07-01

    Full Text Available In a conservation effort, the identification of Tarsier species, on the bases of the morphological andmolecular characteristic is necessary. Up to now, the identification of the animals were based on themorphology and vocalizations, which is extremely difficult to identify each, tarsier species. The objective ofthis research was to study the genetic diversity on ATP6 gene of Tarsius sp. Based on sequencing of PCRproduct using primer ATP6F and ATP6R with 681 nts. PCR product. The sequence of ATP6 fragmentswere aligned with other primates from Gene bank with aid of software Clustal W, and were analyzed usingMEGA program version 4.0. Three different nucleotide sites were found (nucleotide no. 288, 321 and 367.The genetic distance based on nucleotide ATP6 sequence calculated using Kimura 2-parameter modelindicated that the smallest genetic distance 0%, biggest 0.8% and average 0, 2%. The phylogenetic treeusing neighbor joining method based on the sequence of nucleotide ATP6 gene could not be used todifferentiate among T. Dianae (from Central Sulawesi, T. Spectrum (from North Sulawesi, T. bancanus(from lampung, South Sumatera and T.bancanus from West Kalimantan.

  6. Intertextualidade: considerações em torno do dialogismo

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    Ricardo Zani

    2003-06-01

    Full Text Available Este artigo tem a finalidade de contribuir para o reconhecimento do que se convencionou chamar por dialogismo, quando estudado por Mikhail Bakhtin através das obras do escritor francês François Rabelais e outros autores. As propriedades do dialogismo tornaram-se, posteriormente, focos de estudos para pesquisadores como Julia Kristeva, Robert Stam, Diana da Luz e José L. Fiorin, adquirindo também a denominação de intertextualidade e até mesmo de antropofagia, à medida em que um discurso, qualquer que seja este, remete-se a outros ao construir o seu nexo. Surgido no meio literário, o fenômeno dialógico ou intertextual pode ser aplicado à outras mídias como as artes plásticas, o cinema e a publicidade, enquanto estas travam um diálogo com diversas vozes (discursos, sendo perfeitamente reconhecidas, retrabalhadas e apresentando-se com desempenhos diferenciados de suas antecessoras. Como tal, o discurso dialógico é reconhecido quando uma relação entre vozes distintas é mostrada e não há uma necessidade de rompimento com seus modelos, influências e predecessores, ou seja, com a sua relação histórica.

  7. La asistencia ventricular mecánica como puente al trasplante cardíaco: fundamentos y objetivos

    Directory of Open Access Journals (Sweden)

    Carlos García Montero

    2009-04-01

    Full Text Available La introducción clínica de los dispositivos de tercera generación para asistencia cardiocirculatoria ha significado un notable avance en la terapia de los candidatos a trasplante cardíaco en fase de descompensación hemodinámica, mediante la modalidad conocida como puente al trasplante (PAT. La situación actual de dicha estrategia en nuestro país refleja una dispersión de criterios en cuanto a la selección de pacientes, indicación del dispositivo, manejo táctico de las opciones terapéuticas y, especialmente, detección del momento adecuado del trasplante. El presente trabajo: a analiza las características del régimen a flujo continuo y sus consecuencias sobre distintos órganos diana en el contexto de la estrategia PAT; b describe de forma resumida las líneas de actuación cubiertas por los dispositivos mecánicos de uso más frecuente, y, finalmente, c proporciona unas recomendaciones de manejo clínico antes, durante y para el momento de la desconexión del dispositivo. resulta imprescindible una adecuación de los distintos centros implicados en este tipo de terapia si se pretende avanzar en su aplicación y resultados.

  8. Altered microRNA expression profile in exosomes during osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.

    Directory of Open Access Journals (Sweden)

    Ji-Feng Xu

    Full Text Available The physiological role of microRNAs (miRNAs in osteoblast differentiation remains elusive. Exosomal miRNAs isolated from human bone marrow-derived mesenchymal stem cells (BMSCs culture were profiled using miRNA arrays containing probes for 894 human matured miRNAs. Seventy-nine miRNAs (∼8.84% could be detected in exosomes isolated from BMSC culture supernatants when normalized to endogenous control genes RNU44. Among them, nine exosomal miRNAs were up regulated and 4 miRNAs were under regulated significantly (Relative fold>2, p<0.05 when compared with the values at 0 day with maximum changes at 1 to 7 days. Five miRNAs (miR-199b, miR-218, miR-148a, miR-135b, and miR-221 were further validated and differentially expressed in the individual exosomal samples from hBMSCs cultured at different time points. Bioinformatic analysis by DIANA-mirPath demonstrated that RNA degradation, mRNA surveillance pathway, Wnt signaling pathway, RNA transport were the most prominent pathways enriched in quantiles with differential exosomal miRNA patterns related to osteogenic differentiation. These data demonstrated exosomal miRNA is a regulator of osteoblast differentiation.

  9. A study on family communication pattern and parenting styles with quality of life in adolescent.

    Science.gov (United States)

    Sanavi, Fariba Shahhraki; Baghbanian, Abdolvahab; Shovey, Mehdi Faraji; Ansari-Moghaddam, Alireza

    2013-11-01

    To investigate the relationship between parenting styles and family communication patterns with adolescent's quality of life. The cross-sectional study was carried out on 439 randomly selected adolescents in the city of Zahedan, Iran, from January to July 2011.The subjects were asked to complete the KIDSCREEN-52 health-related quality of life questionnaire, while their parents were asked to complete the Diana Brinder's Test to show their parenting styles. SPSS 15 was used to analyse data. Most parents had 'authoritative' parenting style (n = 380; 86.6%). Pluralistic (n = 170; 38.7%) and consensual (n = 152; 34.6%) patterns were the most frequent styles of communication in families. Data suggested a significant relationship between parenting style and some dimensions of quality of life, including physical well-being, psychological well-being, social support and peers, and autonomy (p parent relation and home life (p quality-of-life. Effort should be made to address problems facing parents while raising their children.

  10. HUBUNGAN ANTARA KOHESIVITAS DENGAN INTENSI PERILAKU AGRESI PADA SUPORTER SEPAK BOLA

    Directory of Open Access Journals (Sweden)

    Anfa Safitri

    2016-05-01

    Full Text Available This research aims to find out there is whether or not a corelation between cohesivity with intention of aggression behavior on football supporters. Early allegations put forward in the present study is there is a positive corelation between cohesiveness with Intention of aggression behaviour. The subjects in this research is 50 student Supporters of football Slemania, everything is made up of men. The scale is a scale used Intention of aggression behaviour laid out based on intention behavior researchers according to the aspect Fishbein dan Ajzen (1975 \\the General behavior of aggression according to classification Buss & Perry (Nashori & Diana, 2007,  as for measuring cohesiveness using aspects of forsyth (1999.Methods of data analysis conducted in the present study uses statistical analysis using correlation spearmant correlation coefficients of r = 0,265 show with p = 0, 014  (p<0,05. Correlation analysis can be taken to mean that there is a very significant positive relationship between cohesiveness with Intention of aggression behaviour on football supporters. That means the higher the level of cohesiveness owned by supporters then it will be the higher Intention of aggression behaviour. Conversely, the lower the level of cohesiveness that it will be the lower clubs too Intention of aggression behaviour.

  11. Aptámeros: agentes diagnósticos y terapéuticos = Aptamers: diagnostic and therapeutic agents

    Directory of Open Access Journals (Sweden)

    Frank J Hernandez

    2012-04-01

    Full Text Available Los aptámeros son ácidos nucleicos de cadena sencilla, ADN o ARN, que reconocen una gran variedad de moléculas. Cada aptámero posee una estructura tridimensional particular que le permite unirse con afinidad y especificidad altas a la molécula diana. Los aptámeros tienen propiedades de reconocimiento equiparables a las de los anticuerpos; sin embargo, por la naturaleza de su composición tienen ventajas significativas en cuanto a su tamaño, producción y modificación. Estas características los hacen excelentes candidatos para el desarrollo de nuevas plataformas biotecnológicas. Se han identificado aptámeros con propiedades terapéuticas que han sido evaluados exitosamente en modelos animales; entre ellos, algunos se encuentran en fase clínica y uno ya fue aprobado para tratamiento por la FDA (Food and Drug Administration. Todos estos avances ocurridos durante las dos últimas décadas permiten anticipar el protagonismo que tendrán los aptámeros como agentes diagnósticos y terapéuticos en un futuro cercano.

  12. Picasso Paintings, Moon Rocks, and Hand-Written Beatles Lyrics: Adults' Evaluations of Authentic Objects.

    Science.gov (United States)

    Frazier, Brandy N; Gelman, Susan A; Wilson, Alice; Hood, Bruce

    2009-01-01

    Authentic objects are those that have an historical link to a person, event, time, or place of some significance (e.g., original Picasso painting; gown worn by Princess Diana; your favorite baby blanket). The current study examines everyday beliefs about authentic objects, with three primary goals: to determine the scope of adults' evaluation of authentic objects, to examine such evaluation in two distinct cultural settings, and to determine whether a person's attachment history (i.e., whether or not they owned an attachment object as a child) predicts evaluation of authentic objects. We found that college students in the U.K. (N = 125) and U.S. (N = 119) consistently evaluate a broad range of authentic items as more valuable than matched control (inauthentic) objects, more desirable to keep, and more desirable to touch, though only non-personal authentic items were judged to be more appropriate for display in a museum. These patterns were remarkably similar across the two cultural contexts. Additionally, those who had an attachment object as a child evaluated objects more favorably, and in particular judged authentic objects to be more valuable. Altogether, these results demonstrate broad endorsement of "positive contagion" among college-educated adults.

  13. Differential miRNA expression in B cells is associated with inter-individual differences in humoral immune response to measles vaccination.

    Science.gov (United States)

    Haralambieva, Iana H; Kennedy, Richard B; Simon, Whitney L; Goergen, Krista M; Grill, Diane E; Ovsyannikova, Inna G; Poland, Gregory A

    2018-01-01

    MicroRNAs are important mediators of post-transcriptional regulation of gene expression through RNA degradation and translational repression, and are emerging biomarkers of immune system activation/response after vaccination. We performed Next Generation Sequencing (mRNA-Seq) of intracellular miRNAs in measles virus-stimulated B and CD4+ T cells from high and low antibody responders to measles vaccine. Negative binomial generalized estimating equation (GEE) models were used for miRNA assessment and the DIANA tool was used for gene/target prediction and pathway enrichment analysis. We identified a set of B cell-specific miRNAs (e.g., miR-151a-5p, miR-223, miR-29, miR-15a-5p, miR-199a-3p, miR-103a, and miR-15a/16 cluster) and biological processes/pathways, including regulation of adherens junction proteins, Fc-receptor signaling pathway, phosphatidylinositol-mediated signaling pathway, growth factor signaling pathway/pathways, transcriptional regulation, apoptosis and virus-related processes, significantly associated with neutralizing antibody titers after measles vaccination. No CD4+ T cell-specific miRNA expression differences between high and low antibody responders were found. Our study demonstrates that miRNA expression directly or indirectly influences humoral immunity to measles vaccination and suggests that B cell-specific miRNAs may serve as useful predictive biomarkers of vaccine humoral immune response.

  14. Õppematerjalide koostajad said autoristipendiumid : [Euroopa Liidu PHARE eesti keele õppe programm toetab aastal 2000 eesti keele kui võõrkeele õppematerjalide väljaandmist üldhariduskoolidele] / EL PHARE eesti keele õppe programm

    Index Scriptorium Estoniae

    2000-01-01

    Stipendiumid metoodikavihikute kirjutamiseks on saanud : Hiie Asser, Maire Kübarsepp "Võõrkeeletunni planeerimine ja ülesehitus", Elle Sõrmus, Leelo Kingisepp "Ülevaade võõrkeeleõppe meetoditest", Piret Kärtner "Lugemisoskuse arendamine", "Kirjutamisoskuse arendamine", "Kuulamisoskuse arendamine", "Kõnelemisoskuse arendamine", Kristi Saarso "Sõnavara õpetamine", Ingrid Krall, Elle Sõrmus "Eesti keele grammatika õpetamise võimalusi", Diana Maisla "Vigade parandamine", Tiina Kikerpill, Leelo Kingisepp "Keelekeskkond võõrkeeleõppe toetajana", Ene Peterson "Video võõrkeeletunnis". Stipendiumid käsiraamatute väljaandmiseks said : Hille Pajupuu "Kuidas kohaneda võõras kultuuris", Krista Kerge "Eesti keele praktiline süntaks", Einar Kraut "Hääldus - uks teise keelde". PHARE programmi toetusel ilmuvad materjalid muukeelsete üldhariduskoolide õpetajatele : Aino Siirak "Suured seinatabelid eesti keele grammatika õpetamiseks", Hiie Asser, Maire Küppar, Anne Kaskman "Lüümikute komplekt esimesele kooliastmele", Meeme Liivak, Elve Voltein "Laulumängude kogumik". Täiskasvanute keeleõpet toetab PHARE programm õpikuga : Antidea Metsa, Anne Jänese "Sulle, õpetaja!". PHARE toetusel töötatakse välja ka edasijõudnutele mõeldud eesti keele õppekomplekt, mille autor on Mare Kitsing

  15. Molecular diversity of Cotton leaf curl Gezira virus isolates and their satellite DNAs associated with okra leaf curl disease in Burkina Faso

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    Reynaud Bernard

    2010-02-01

    Full Text Available Abstract Okra leaf curl disease (OLCD is a major constraint on okra (Abelmoschus esculentus production and is widespread in Africa. Using a large number of samples representative of the major growing regions in Burkina Faso (BF, we show that the disease is associated with a monopartite begomovirus and satellite DNA complexes. Twenty-three complete genomic sequences of Cotton leaf curl Gezira virus (CLCuGV isolates associated with OLCD, sharing 95 to 99% nucleotide identity, were cloned and sequenced. Six betasatellite and four alphasatellite (DNA-1 molecules were also characterized. The six isolates of betasatellite associated with CLCuGV isolates correspond to Cotton leaf curl Gezira betasatellite (CLCuGB (88 to 98% nucleotide identity. One isolate of alphasatellite is a variant of Cotton leaf curl Gezira alphasatellite (CLCuGA (89% nucleotide identity, whereas the three others isolates appear to correspond to a new species of alphasatellite (CLCuGA most similar sequence present 52 to 60% nucleotide identity, provisionally named Okra leaf curl Burkina Faso alphasatellite (OLCBFA. Recombination analysis of the viruses demonstrated the interspecies recombinant origin of all CLCuGV isolates, with parents being close to Hollyhock leaf crumple virus (AY036009 and Tomato leaf curl Diana virus (AM701765. Combined with the presence of satellites DNA, these results highlight the complexity of begomoviruses associated with OLCD.

  16. Estudio de marcadores biológicos asociados al desarrollo de edema en la isquemia cerebral: estudio clínico-experimental

    OpenAIRE

    Moldes Miguélez, Octavio

    2011-01-01

    En los países occidentales el ictus es la  segunda causa de muerte y la primera causa deincapacidad en el adulto. Uno de los factoresque más contribuye al deterioro de los  pacientes es el edema cerebral, por lo que esnecesario la búsqueda de marcadores  biológicos, que puedan predecir el desarrollode edema cerebral, y puedan ser nuevas dianas  terapéuticas en el tratamiento del edema  cerebral. La endotelina‐1 (ET‐1), péptido vasoconstrictor de larga duración, es producida en las células ...

  17. Efectos adversos de la acumulación renal de hemoproteínas. Nuevas herramientas terapéuticas

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    Melania Guerrero-Hue

    2018-01-01

    Full Text Available La hemoglobina y la mioglobina son hemoproteínas que juegan un papel fundamental en el organismo ya que participan en el transporte de oxígeno. Sin embargo, debido a su estructura química, estas moléculas pueden ejercer efectos deletéreos cuando se liberan al torrente sanguíneo de forma masiva, como sucede en determinadas condiciones patológicas asociadas a rabdomiólisis o hemólisis intravascular. Una vez en el plasma, estas hemoproteínas se pueden filtrar y acumular en el riñón, donde resultan citotóxicas, principalmente para el epitelio tubular, e inducen fracaso renal agudo y enfermedad renal crónica. En la presente revisión analizaremos los distintos contextos patológicos que provocan la acumulación renal de estas hemoproteínas, su relación con la pérdida de función renal a corto y largo plazo, los mecanismos fisiopatólogicos responsables de sus efectos adversos y los sistemas de defensa que contrarrestan tales acciones. Por último, describiremos los distintos tratamientos utilizados actualmente y mostraremos nuevas opciones terapéuticas basadas en la identificación de nuevas dianas celulares y moleculares, prestando especial atención a los diversos ensayos clínicos que se encuentran en marcha en la actualidad.

  18. [Personality traits of women participating in a breast cancer prevention trial].

    Science.gov (United States)

    Martino, Gemma; Bellati, Cristina; Cola, Alberto; Galperti, Gabriella; Krogh, Vittorio; Luci, Simona; Raimondi, Milena

    2002-01-01

    We have evaluated the psycho-social factors in women--during menopause with different biological characteristics--who participated in two extensive trials of breast cancer prevention: Diana1 and Tamoxifen. Through the use of a recognized personality test (MMPI, Minnesota Multiphasic Personality Inventory), we observed 500 healthy women who agreed to or refused the health care proposal. The findings show that the women who accept chemical preparations or to modify their dietary habits present different personality traits from those who refuse to adhere. One should ask oneself if the lack of homogeneity of the samples with a different concentration of psycho-social factors can alter the efficacy of a cancer prevention program. During chemoprevention studies, in which a high compliance could bring about a redundancy of experience of sickness, in coherence with our goal of health protection, we think it is necessary to supply psycho-social support which tempers any experience of physical, psychological and inter-personal discomfort in the healthy women. The cognitive model of the personality traits could be programmed also for the compliance of mammographical screening. This model requires the training of health care professionals.

  19. Flavonoids in white and yellow perianths and yellow anthers of tulips (Tulipa gesneriana L.

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    Marcin Horbowicz

    2013-12-01

    Full Text Available The content of flavonoids in white and yellow perianths and yellow anthers of a few tulip cultivars were determined at the stage of full flowering. To analyses of flavonols a HPLC method was used. In anthers (yellow of all analyzed cultivars (Oscar, Pax, Profesor Wóycicki, Biała Dama, White Virgin, Calypso, Diana high content of quercetin (2,35 - 6,01 mg·g-1 F.W., kaempferol (1,09 - 9,47 mg·g-1 F.W. and apigenin (1,34 - 8,24 mg·g-1 F.W. was found. In analyzed white perianth of cvs. Oscar and White Virgin also high content of quercetin (1,3 - 1,80 mg·g-1 F.W. and kaempferol (1,90 mg·g-1 F.W. was documented and only traces of apigenin was found. In the yellow perianth of cv. Profesor Wóycicki the level of quercetin and kaempferol was much lower than in perianth of cvs. Oscar and White Virgin, and apigenin was absent. Thus, yellow anthers and white and yellow perianth of tulip cultivars are a rich source of flavonols.

  20. A study on family communication pattern and parenting styles with quality of life in adolescent

    International Nuclear Information System (INIS)

    Sanavi, F.S.; Baghbanian, A.; Shovey, M.F.; Moghaddam, A.A

    2013-01-01

    Objective: To investigate the relationship between parenting styles and family communication patterns with adolescent's quality of life. Methods: The cross-sectional study was carried out on 439 randomly selected adolescents in the city of Zahedan, Iran, from January to July 2011. The subjects were asked to complete the KIDSCREEN-52 health-related quality of life questionnaire, while their parents were asked to complete the Diana Brinder's Test to show their parenting styles. SPSS 15 was used to analyse data. Results: Most parents had authoritative parenting style (n=380; 86.6%). Pluralistic (n=170; 38.7%) and consensual (n=152; 34.6%) patterns were the most frequent styles of communication in families. Data suggested a significant relationship between parenting style and some dimensions of quality of life, including physical well-being, psychological well-being, social support and peers, and autonomy (p<0.05). There was also a significant relationship between family communication patterns and parent relation and home life (p<0.001) as well as autonomy (p<0.006). Conclusion: Families play a critical role in increasing adolescents, health-related quality-of-life. Effort should be made to address problems facing parents while raising their children. (author)

  1. Impacto de la vacunación contra Haemophilus influenzae tipo b en Cuba

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    Dickinson Félix O.

    2001-01-01

    Full Text Available Objetivo. Determinar el impacto de la vacunación de menores de 2 años en Cuba contra Haemophilus influenzae tipo b (Hib, principal agente causal de la meningitis bacteriana en ese país. Métodos. La disponibilidad de vacunas conjugadas eficaces contra Hib motivó la vacunación nacional en 1999 de niños menores de 2 años, que alcanzó una cobertura de 97%. El impacto se evaluó mediante el Sistema Nacional de Vigilancia de Meningoencefalitis Bacterianas (SNVMEB. Resultados. La eficacia global de la vacunación se estimó en 99% y la incidencia general de la meningoencefalitis por Hib disminuyó de 1,3 a 0,6 por 100 000 habitantes (46,1%, observándose la mayor reducción en niños menores de 5 años (56,1%. En los menores de 1 año se redujo 70,5% y en el resto de los grupos de menores de 5 años disminuyó entre 25,9 y 49,6%. En el grupo diana para la vacunación, la incidencia se redujo 61,1%; entre los niños de este grupo que contrajeron la meningoencefalitis por Hib, solamente 8 (24,2% estaban vacunados, 7 de ellos con una sola dosis, aplicada 1 mes antes de enfermar. Conclusiones. Se ha demostrado que la vacunación a gran escala de los niños menores de 2 años contra Hib en Cuba a través del SNVMEB ha logrado disminuir notablemente la incidencia de meningoencefalitis por Hib.

  2. Clinical behavior of a cohort of adult women with facial acne treated with combined oral contraceptive: ethinylestradiol 20 µg/dienogest 2 mg

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    Palacio-Cardona J

    2017-11-01

    Full Text Available John Palacio-Cardona,1 Diana María Caicedo Borrero2 1Student Welfare Service – Health Area, Santiago de Cali University, 2Support for Research, Academic, Scientific and Technological Services (SEACIT, Cali, Colombia Abstract: Acne vulgaris is the most common skin disease. It affects the young adult female population and generates great impact on physical and mental health. One of the treatments with good results for affected women is combined oral contraceptive pills (COCPs. The aim of this study was to determine the clinical effect of facial acne management with ethinylestradiol 20 µg/dienogest 2 mg in a cohort of Colombian adult women. A cohort of 120 female university students was followed for 12 months. These participants were enrolled in the Sexual and Reproductive Health Program of the Santiago de Cali University. This cohort admitted women between 18 and 30 years old who had chosen to start birth control with ethinylestradiol 20 µg/dienogest 2 mg COCPs, did not have contraindi­cations to the use of COCPs, and had been diagnosed with acne. Monthly monitoring of facial acne lesion count was performed. Relative changes in facial lesion count were identified. At the end of follow-up, the percentage of reduction of lesions was 94% and 23% of women had a 100% reduction in acne lesions. In conclusion, the continued use of the ethinylestradiol 20 µg/dienogest 2 mg COCPs reduced inflammatory and non-inflammatory acne lesions in reproductive-age women between 18 and 30 years of age with no severe acne. Keywords: skin diseases, acne vulgaris, reproductive control agents, contraceptive agents, female contraceptive agents, oral, hormonal

  3. Dental Blogs, Podcasts, and Associated Social Media: Descriptive Mapping and Analysis.

    Science.gov (United States)

    Melkers, Julia; Hicks, Diana; Rosenblum, Simone; Isett, Kimberley R; Elliott, Jacqueline

    2017-07-26

    Studies of social media in both medicine and dentistry have largely focused on the value of social media for marketing to and communicating with patients and for clinical education. There is limited evidence of how dental clinicians contribute to and use social media to disseminate and access information relevant to clinical care. The purpose of this study was to inventory and assess the entry, growth, sources, and content of clinically relevant social media in dentistry. We developed an inventory of blogs, podcasts, videos, and associated social media disseminating clinical information to dentists. We assessed hosts' media activity in terms of their combinations of modalities, entry and exit dates, frequency of posting, types of content posted, and size of audience. Our study showed that clinically relevant information is posted by dentists and hygienists on social media. Clinically relevant information was provided in 89 blogs and podcasts, and topic analysis showed motives for blogging by host type: 55% (49 hosts) were practicing dentists or hygienists, followed by consultants (27 hosts, 30%), media including publishers and discussion board hosts (8 hosts, 9%), and professional organizations and corporations. We demonstrated the participation of and potential for practicing dentists and hygienists to use social media to share clinical and other information with practicing colleagues. There is a clear audience for these social media sites, suggesting a changing mode of information diffusion in dentistry. This study was a first effort to fill the gap in understanding the nature and potential role of social media in clinical dentistry. ©Julia Melkers, Diana Hicks, Simone Rosenblum, Kimberley R Isett, Jacqueline Elliott. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 26.07.2017.

  4. Perceptions of diabetes obtained through drawing in childhood and adolescence

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    Isla Pera P

    2013-06-01

    Full Text Available Pilar Isla Pera,1 María Palacin Lois,2 Carmen López Matheu,1 María Honrubia Pérez,1 Ana María Gómez Rodriguez,3 Eulalia Armengol Camps,4 Carmen Sanchez Villalba,5 Roser Insa Soria,6 Assumpta Rigol Cuadra,1 Diana Marre71Nursing School, University of Barcelona, Barcelona, Spain; 2Facultad Psicologia, University of Barcelona, Barcelona, Spain; 3Endocrinology Unit, Hospital Sant Joan de Deu, Barcelona, Spain; 4Endocrinology Unit, Hospital Vall d'Hebrón, Barcelona, Spain; 5Sanatorium Hospital Foundation The Holy Spirit, Santa Coloma de Gramenet, Catalonia, Spain; 6Endocrinology Unit, Hospital Universitari de Bellvitge, Barcelona, Spain; 7Antropologia Social y Cultural, Universitat Autònoma de Barcelona, Barcelona, SpainObjective: To examine whether drawing is useful in the detection of problems of psychosocial adaptation in children and adolescents with type 1 diabetes (T1D and in improving communication with health professionals.Methods: We performed an exploratory descriptive study in 199 children and adolescents with T1D aged 4–13 years. The participants were asked to render a drawing on a suggested topic. The variables analyzed were related to the drawing and to clinical and sociodemographic data.Results: Most participants showed evidence of having a well-balanced personality, but there were also signs of affective or psychosocial difficulties.Conclusion: Drawing is a useful technique by which to identify children’s and adolescents’ feelings and possible problems in adapting to T1D, as well as to gain information directly from the children themselves. Future studies should delimit the possibilities of this technique in clinical practice in greater detail.Keywords: type 1 diabetes mellitus, childhood and adolescence, drawing, psychosocial factors

  5. Ranking of microRNA target prediction scores by Pareto front analysis.

    Science.gov (United States)

    Sahoo, Sudhakar; Albrecht, Andreas A

    2010-12-01

    Over the past ten years, a variety of microRNA target prediction methods has been developed, and many of the methods are constantly improved and adapted to recent insights into miRNA-mRNA interactions. In a typical scenario, different methods return different rankings of putative targets, even if the ranking is reduced to selected mRNAs that are related to a specific disease or cell type. For the experimental validation it is then difficult to decide in which order to process the predicted miRNA-mRNA bindings, since each validation is a laborious task and therefore only a limited number of mRNAs can be analysed. We propose a new ranking scheme that combines ranked predictions from several methods and - unlike standard thresholding methods - utilises the concept of Pareto fronts as defined in multi-objective optimisation. In the present study, we attempt a proof of concept by applying the new ranking scheme to hsa-miR-21, hsa-miR-125b, and hsa-miR-373 and prediction scores supplied by PITA and RNAhybrid. The scores are interpreted as a two-objective optimisation problem, and the elements of the Pareto front are ranked by the STarMir score with a subsequent re-calculation of the Pareto front after removal of the top-ranked mRNA from the basic set of prediction scores. The method is evaluated on validated targets of the three miRNA, and the ranking is compared to scores from DIANA-microT and TargetScan. We observed that the new ranking method performs well and consistent, and the first validated targets are elements of Pareto fronts at a relatively early stage of the recurrent procedure, which encourages further research towards a higher-dimensional analysis of Pareto fronts. Copyright © 2010 Elsevier Ltd. All rights reserved.

  6. PARENTING AND ITS INFLUENCE ON CHILD BEHAVIOUR

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    Jiji Mary Antony

    2017-12-01

    Full Text Available BACKGROUND Parenting is the process of giving care to the young and preparing them to face the challenges of life. Diana Baumrind introduced the models of parenting, authoritative, authoritarian and permissive depending on the level of demandingness and responsiveness. Defective parenting is associated with problem behaviours in children. This study was undertaken to find out which parenting style is least associated with behavioural problems and what are the problems associated with the different parenting style. MATERIALS AND METHODS 46 children who were admitted with minor illness at the institute of Child Health, Kottayam from January 2017 to Oct 2017 were enrolled after getting informed consent and IRB clearance. Purposive sampling method were used for the study. Demographic data was entered into a proforma. The PSDQ and CBCL 1½ -5 questionnaire was given to mothers to assess the parenting style and behavioural problems in their children. Data was analysed with statistical tests. The t test, one way ANOVA, Pearson correlation coefficient and regression analyses were used for the analyses. RESULTS The parenting styles of the mothers and the behavioural problems seen in their children were studied in this research. There was no significant difference in behavioural problems between the different age group studied and there was no difference in problem behaviours between male children and female children. Authoritative parenting style was least associated with problem behaviour. Authoritarian parenting style is associated with internalizing problems and permissive parenting is associated with externalizing problems. CONCLUSION Since the behaviour problems tends to linger through adolescence and adulthood, parental education regarding the positive parenting style and interventions can be given from early childhood during routine child care and structured programs.

  7. Risk Assessment for Parents Who Suspect Their Child Has Autism Spectrum Disorder: Machine Learning Approach.

    Science.gov (United States)

    Ben-Sasson, Ayelet; Robins, Diana L; Yom-Tov, Elad

    2018-04-24

    Parents are likely to seek Web-based communities to verify their suspicions of autism spectrum disorder markers in their child. Automated tools support human decisions in many domains and could therefore potentially support concerned parents. The objective of this study was to test the feasibility of assessing autism spectrum disorder risk in parental concerns from Web-based sources, using automated text analysis tools and minimal standard questioning. Participants were 115 parents with concerns regarding their child's social-communication development. Children were 16- to 30-months old, and 57.4% (66/115) had a family history of autism spectrum disorder. Parents reported their concerns online, and completed an autism spectrum disorder-specific screener, the Modified Checklist for Autism in Toddlers-Revised, with Follow-up (M-CHAT-R/F), and a broad developmental screener, the Ages and Stages Questionnaire (ASQ). An algorithm predicted autism spectrum disorder risk using a combination of the parent's text and a single screening question, selected by the algorithm to enhance prediction accuracy. Screening measures identified 58% (67/115) to 88% (101/115) of children at risk for autism spectrum disorder. Children with a family history of autism spectrum disorder were 3 times more likely to show autism spectrum disorder risk on screening measures. The prediction of a child's risk on the ASQ or M-CHAT-R was significantly more accurate when predicted from text combined with an M-CHAT-R question selected (automatically) than from the text alone. The frequently automatically selected M-CHAT-R questions that predicted risk were: following a point, make-believe play, and concern about deafness. The internet can be harnessed to prescreen for autism spectrum disorder using parental concerns by administering a few standardized screening questions to augment this process. ©Ayelet Ben-Sasson, Diana L Robins, Elad Yom-Tov. Originally published in the Journal of Medical Internet

  8. Common features of microRNA target prediction tools

    Directory of Open Access Journals (Sweden)

    Sarah M. Peterson

    2014-02-01

    Full Text Available The human genome encodes for over 1800 microRNAs, which are short noncoding RNA molecules that function to regulate gene expression post-transcriptionally. Due to the potential for one microRNA to target multiple gene transcripts, microRNAs are recognized as a major mechanism to regulate gene expression and mRNA translation. Computational prediction of microRNA targets is a critical initial step in identifying microRNA:mRNA target interactions for experimental validation. The available tools for microRNA target prediction encompass a range of different computational approaches, from the modeling of physical interactions to the incorporation of machine learning. This review provides an overview of the major computational approaches to microRNA target prediction. Our discussion highlights three tools for their ease of use, reliance on relatively updated versions of miRBase, and range of capabilities, and these are DIANA-microT-CDS, miRanda-mirSVR, and TargetScan. In comparison across all microRNA target prediction tools, four main aspects of the microRNA:mRNA target interaction emerge as common features on which most target prediction is based: seed match, conservation, free energy, and site accessibility. This review explains these features and identifies how they are incorporated into currently available target prediction tools. MicroRNA target prediction is a dynamic field with increasing attention on development of new analysis tools. This review attempts to provide a comprehensive assessment of these tools in a manner that is accessible across disciplines. Understanding the basis of these prediction methodologies will aid in user selection of the appropriate tools and interpretation of the tool output.

  9. Migraine in menopausal women: a systematic review

    Directory of Open Access Journals (Sweden)

    Ripa P

    2015-08-01

    Full Text Available Patrizia Ripa,1 Raffaele Ornello,1 Diana Degan,1 Cindy Tiseo,1 Janet Stewart,2 Francesca Pistoia,1 Antonio Carolei,1 Simona Sacco1 1Department of Applied Clinical Sciences and Biotechnology, Institute of Neurology, University of L’Aquila, L’Aquila, Italy; 2Psychology Division, School of Natural Sciences, University of Stirling, Scotland, UK Abstract: Evidence suggests that migraine activity is influenced by hormonal factors, and particularly by estrogen levels, but relatively few studies have investigated the prevalence and characteristics of migraine according to the menopausal status. Overall, population-based studies have shown an improvement of migraine after menopause, with a possible increase in perimenopause. On the contrary, the studies performed on patients referring to headache centers have shown no improvement or even worsening of migraine. Menopause etiology may play a role in migraine evolution during the menopausal period, with migraine improvement more likely occurring after spontaneous rather than after surgical menopause. Postmenopausal hormone replacement therapy has been found to be associated with migraine worsening in observational population-based studies. The effects of several therapeutic regimens on migraine has also been investigated, leading to nonconclusive results. To date, no specific preventive measures are recommended for menopausal women with migraine. There is a need for further research in order to clarify the relationship between migraine and hormonal changes in women, and to quantify the real burden of migraine after the menopause. Hormonal manipulation for the treatment of refractory postmenopausal migraine is still a matter of debate. Keywords: headache, female, menstrual cycle, sex hormones

  10. Mobile Phone Interventions for Sleep Disorders and Sleep Quality: Systematic Review.

    Science.gov (United States)

    Shin, Jong Cheol; Kim, Julia; Grigsby-Toussaint, Diana

    2017-09-07

    Although mobile health technologies have been developed for interventions to improve sleep disorders and sleep quality, evidence of their effectiveness remains limited. A systematic literature review was performed to determine the effectiveness of mobile technology interventions for improving sleep disorders and sleep quality. Four electronic databases (EBSCOhost, PubMed/Medline, Scopus, and Web of Science) were searched for articles on mobile technology and sleep interventions published between January 1983 and December 2016. Studies were eligible for inclusion if they met the following criteria: (1) written in English, (2) adequate details on study design, (3) focus on sleep intervention research, (4) sleep index measurement outcome provided, and (5) publication in peer-reviewed journals. An initial sample of 2679 English-language papers were retrieved from five electronic databases. After screening and review, 16 eligible studies were evaluated to examine the impact of mobile phone interventions on sleep disorders and sleep quality. These included one case study, three pre-post studies, and 12 randomized controlled trials. The studies were categorized as (1) conventional mobile phone support and (2) utilizing mobile phone apps. Based on the results of sleep outcome measurements, 88% (14/16) studies showed that mobile phone interventions have the capability to attenuate sleep disorders and to enhance sleep quality, regardless of intervention type. In addition, mobile phone intervention methods (either alternatively or as an auxiliary) provide better sleep solutions in comparison with other recognized treatments (eg, cognitive behavioral therapy for insomnia). We found evidence to support the use of mobile phone interventions to address sleep disorders and to improve sleep quality. Our findings suggest that mobile phone technologies can be effective for future sleep intervention research. ©Jong Cheol Shin, Julia Kim, Diana Grigsby-Toussaint. Originally published

  11. On the seismic behavior of the main tower of the San Felice sul Panaro (Italy) fortress

    Science.gov (United States)

    Castellazzi, Giovanni; D'Altri, Antonio Maria; de Miranda, Stefano; Magagnini, Stefano; Tralli, Antonio

    2016-12-01

    The medieval fortresses are a very common and distinctive type among the Emilian historical constructions and the earthquakes of May 20th and 29th, 2012 underlined their high vulnerability. Among those heavily damaged, there is the fortress of San Felice sul Panaro located between the two epicenters. This study presents some FE results regarding the behavior under seismic actions of the main tower (Mastio tower). The Mastio has peculiar geometric features and represents a typical example of non-isolated tower. In fact, it is constrained in very different ways by the surrounding parts of the fortress along two of its sides: on the north side it is constrained by the perimeter wall until one third of his high, while a stiffer building constrains it on the west side. In order to remodel the entire fortress, a multidisciplinary project involving the Municipality of San Felice sul Panaro and four Universities of the Emilia- Romagna (Bologna, Ferrara, Parma and Modena) together with the University of Genoa is going on. The study, oriented to the structural restoration, produced an accurate survey of the entire building including a fine definition of architectural peculiarities, historical stages and materials evolution. Based on such geometrical data, we developed a detailed 3D realistic mesh, with a point-by-point characterization of each single geometric element. We performed both pushover and nonlinear dynamic analyses using accelerograms data measured near the fortress on May 29th. A damage-plasticity material model exhibiting softening in both tension and compression, already available in the commercial code Abaqus, has been used for masonry in nonlinear dynamic analyses. On the other hand, pushover analyses have been performed utilizing similar constitutive equations available on code DIANA. The effects of higher modes of vibration have been taken into account by means of the modal pushover analysis technique. For the sake of conciseness, only some preliminary

  12. The feasibility of using electronic clinical outcome assessments in people with schizophrenia and their informal caregivers

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    Tolley C

    2015-03-01

    Full Text Available Chloe Tolley,1 Diana Rofail,2 Adam Gater,1 Justine K Lalonde31Adelphi Values Ltd, Bollington, UK; 2Roche Products Ltd, Welwyn Garden City, UK; 3Roche S.A.S, Paris, France Abstract: Many clinical outcome assessments (COAs were originally developed for completion via pen and paper. However, in recent years there have been movements toward electronic capture of such data in an effort to reduce missing data, provide time-stamped records, minimize administrative burden, and avoid secondary data entry errors. Although established in many patient populations, the implications of using electronic COAs in schizophrenia are unknown. In accordance with International Society for Pharmacoeconomics and Outcomes Research (ISPOR Task Force recommendations, in-depth cognitive debriefing and usability interviews were conducted with people with schizophrenia (n=12, their informal (unpaid caregivers (n=12, and research support staff (n=6 to assess the suitability of administration of various electronic COA measures using an electronic tablet device. Minimal issues were encountered by participants when completing or administering the COAs in electronic format, with many finding it easier to complete instruments in this mode than by pen and paper. The majority of issues reported were specific to the device functionality rather than the electronic mode of administration. Findings support data collection via electronic tablet in people with schizophrenia and their caregivers. The appropriateness of other forms of electronic data capture (eg, smartphones, interactive voice response systems, etc is a topic for future investigation. Keywords: ePRO, eCOA, mode of administration, electronic data capture, usability 

  13. Clinical features of adolescents with deliberate self-harm: A case control study in Lisbon, Portugal

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    Diogo F Guerreiro

    2009-11-01

    Full Text Available Diogo F Guerreiro, Ema L Neves, Rita Navarro, Raquel Mendes, Ana Prioste, Diana Ribeiro, Tiago Lila, António Neves, Mónica Salgado, Nazaré Santos, Daniel SampaioYouth Suicide Study Group (NES, The Hospital Santa Maria, Psychiatry Department, Lisbon Faculty of Medicine, PortugalAbstract: Deliberate self-harm (DSH among adolescents is a high-risk condition for suicide. The aim of the present study is to describe the characteristic clinical features of adolescents with DSH according to our local context (Lisbon, Portugal, using easily available information from clinical settings. A case control study was constructed from a sample of 100 adolescents (aged 12 to 21 years. The sample was divided into two groups: adolescents with and without DSH. Case files were examined and data was completed by clinical interviews. Demographic, psychosocial, and psychopathological data were assessed and compared. Ninety-eight subjects completed the protocol. The DSH group was associated with the following: suicidal ideation or suicidal behavior as consultation motive, emergency room referral, previous follow-up attempts, suicidal ideation, psychosocial difficulties, or lack of therapeutic goals. There was a nonsignificant trend towards diagnosis of depression in the DSH group. These results reflect our clinical practice with adolescents and add data about teenagers who self-harm to the literature. Prevention and early recognition of DSH (and frequently associated depression in adolescents are essential and could be life-saving measures. An integrated approach, which takes into account psychosocial difficulties, family dysfunction, and negative expectations, seems to be of great importance.Keywords: deliberate self-harm, suicide, adolescents, suicide risk, case control

  14. Creencias adolescentes sobre la violencia de género. Sexismo en las relaciones entre adolescentes

    Directory of Open Access Journals (Sweden)

    Zoraida de la Osa Escudero

    2013-12-01

    Full Text Available El presente trabajo indaga en las relaciones de pareja en la adolescencia, analizando las creencias de los y las adolescentes atendiendo al factor violencia de género desde una perspectiva cognitivo-evolutiva. La muestra está compuesta por 297 estudiantes con edades comprendidas entre los 13 y 18 años (2º ESO, 4º ESO y 2º Bachillerato de tres centros privados-concertados de Madrid. Analizamos sus representaciones de las relaciones de pareja desde el punto de vista de ambos géneros y su grado de acuerdo con la justificación de violencia. El estudio responde a un diseño transversal (cuasi-experimental con encuesta. El instrumento utilizado es una adaptación del Cuestionario de Actitudes hacia la Diversidad y la Violencia (CADV. Los resultados muestran una correspondencia parcial en la relación entre el desarrollo evolutivo-moral y el grado de justificación de diferentes situaciones en las que se presenta la violencia. De acuerdo con nuestros datos, el acuerdo con creencias sexistas y justificación de la violencia desciende según se avanza en la escolarización. Al mismo tiempo, obtenemos que es en el tramo de edad de quince a dieciséis años (4º ESO donde justifican más los estereotipos de género. Todo ello nos lleva a señalar la adolescencia media como curso diana en el que realizar una intervención psicoeducativa considerando los valores relacionados con la igualdad y el respeto entre los géneros

  15. Factors associated with reductions in alcohol use between high school and college: an analysis of data from the College Alcohol Study

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    Swann CA

    2014-02-01

    Full Text Available Christopher A Swann,1 Michelle Sheran,1 Diana Phelps2 1Department of Economics, University of North Carolina at Greensboro, Greensboro, NC, USA; 2RTI International, Research Triangle Park, NC, USA Background: The consumption of alcohol by college students is a significant public health concern, and a large amount of literature explores this issue. Much of the focus is on the prevalence and correlates of binge drinking. Relatively few studies explore reductions in drinking, and these generally focus on reductions that occur during college. Aims: We examined the transition between high school and college and sought to understand the characteristics and behaviors of students that are related to reductions in the consumption of alcohol during this transition. Methods: We used data from all four rounds of the Harvard School of Public Health's College Alcohol Survey and logistic regression models to relate the status of reduced alcohol consumption to five groups of variables: demographic and parental variables, other substance use, social environment, student activities, and alcohol policies. Results: A number of characteristics were related to reductions in drinking. Students whose fathers did not attend college were more likely to reduce alcohol consumption (odds ratio [OR] =1.28; 95% confidence interval [CI] =1.06–1.55, whereas students who prioritize parties (OR =0.35; CI =0.30–0.43 and who have recently smoked cigarettes (OR =0.52; CI =0.41–0.64 or marijuana (OR =0.52; CI =0.40–0.67 or whose fathers are moderate (OR =0.73; CI =0.55–0.96 or heavy (OR =0.72; CI =0.53–0.96 drinkers were less likely to reduce alcohol consumption. Conclusion: The results highlight the importance of family background and social environment on reductions in drinking. Keywords: binge drinking, College Alcohol Study, college drinking, reductions in alcohol consumption

  16. Morphological features of Persica species and varieties in the Forest-Steppe zone of Ukraine

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    І. М. Голубкова

    2017-03-01

    Full Text Available Purpose. To determine morphological and morphometric features of vegetative and generative organs of Persica species and varieties under the conditions of the Forest-Steppe zone of Ukraine for further use in breeding. Methods. Biological (morphological analysis and statistical (processing of morphometric parameters ones. Results. It was found that except ternate multiple buds, in peach hybrid ‘Suputnyk’collateral buds were prevalent which was not common to other tested varieties and species. Buds of each species and variety have a certain number of scales. The most scales were observed in ‘Suputnyk’. Pubescence of abaxial side of the leaf in P. davіdiana and ‘Suputnyk’ plants was not revealed. Species of P. vulgaris (‘Pecherskyi’, ‘Antotsianovyi’, ‘Poleskyi’ was characterized by increase in size of leaf blades, flowers and fruits. The distinctive features of P. davidiana and ‘Suputnyk’ are that stamens were accumulated in their flowers while in P. vulgaris they are branched. Raphe of a P. vulgaris stone protrudes above the edges of the bordering creases and consists of a number of narrow plates. Conclusions. For the breeding purposes, plants have an advantage for some basic criteria: the most flower buds that is common to interspecies hybrid ‘Suputnyk’; increase in photosynthetic productivity of the leaf apparatus to be typical for the variety ‘Pecherskyi’; large fruits that ‘Pecherskyi’ variety is noted for; intense red color of fruits that is inherent feature of ‘Antocianovyi’ variety.

  17. New standards in hypertension and cardiovascular risk management: focus on telmisartan

    Directory of Open Access Journals (Sweden)

    Domenico Galzerano

    2010-03-01

    Full Text Available Domenico Galzerano1, Cristina Capogrosso4, Sara Di Michele2, Antonio Galzerano1, Paola Paparello1, Diana Lama3, Carlo Gaudio21Department of Cardiology, San Gennaro Hospital, Naples, Italy; 2Department of Heart and Great Vessels, A. Reale, La Sapienza University, Rome, Italy; 3V Division of Internal Medicine, II University, Naples, Italy; 4Cardiology Division, San Giovanni Bosco Hospital, Naples, ItalyAbstract: Blockade of the renin–angiotensin system is an important approach in managing high blood pressure, and has increasingly been shown to affect cardiovascular disease processes mediated by angiotensin II throughout the cardiovascular and renal continua. Telmisartan is an angiotensin II receptor blocker (ARB displaying unique pharmacologic properties, including a longer half life than any other ARB, that result in large and sustained reductions of blood pressure. In patients with mild-to-moderate hypertension, telmisartan has proved superior to other antihypertensive agents (valsartan, losartan, ramipril, perindopril, and atenolol in controlling blood pressure particularly towards the end of the dosing interval. There is also clinical evidence that telmisartan reduces left ventricular hypertrophy, reduces arterial stiffness and the recurrence of atrial fibrillation, and confers renoprotection. The ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial (ONTARGET® study has demonstrated that telmisartan has similar cardiovascular protective effects to ramipril in a large, high-risk patient population but was better tolerated. The powerful and sustained blood pressure control apparent in clinical trials, together with cardiovascular protection and tolerability demonstrated in ONTARGET® means that telmisartan may be a preferred option for patients with hypertension.Keywords: angiotensin II receptor blocker, cardiovascular disease, hypertension, renin–angiotensin system, telmisartan

  18. Psicofarmacología de la Psicosis: Elección del Fármaco, Adherencia al Tratamiento y Nuevos Horizontes

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    Adela Pérez Escudero

    2010-01-01

    Full Text Available Los autores presentan una actualización del tratamiento antipsicótico de la psicosis, centrándose en tres aspectos: la elección del fármaco antipsicótico, el problema de la adherencia y los tratamientos aún en fase de investigación. El antipsicótico a elegir en el tratamiento debe tener en cuenta tanto características individuales de cada paciente, preferencias, como características clínicas de la enfermedad. Se revisan las principales guías de tratamiento para hacer una buena elección del fármaco atendiendo al mecanismo de acción y perfil de efectos secundarios, respuesta clínica, fase de la enfermedad, pacientes resistentes, etc. Uno de los grandes problemas del tratamiento farmacológico en la psicosis es conseguir una buena tasa de adherencia al mismo, para ello se revisan las estrategias psicofarmacológicas, psicoterapéuticas y psicosociales que puedan favorecerla. La investigación actual se centra en la búsqueda de nuevos fármacos con características de atipicidad similar a los ya existentes (bloqueo de múltiples receptores, agonismo parcial dopaminérgico, fármacos atípicos ya conocidos con nuevas presentaciones, principalmente de acción retardada que puede favorecer la adherencia y nuevas dianas, especialmente la acción sobre la vía glutamatérgica.

  19. PREFACE: 2nd International Conference on Innovative Materials, Structures and Technologies

    Science.gov (United States)

    Ručevskis, Sandris

    2015-11-01

    The 2nd International Conference on Innovative Materials, Structures and Technologies (IMST 2015) took place in Riga, Latvia from 30th September - 2nd October, 2015. The first event of the conference series, dedicated to the 150th anniversary of the Faculty of Civil Engineering of Riga Technical University, was held in 2013. Following the established tradition, the aim of the conference was to promote and discuss the latest results of industrial and academic research carried out in the following engineering fields: analysis and design of advanced structures and buildings; innovative, ecological and energy efficient building materials; maintenance, inspection and monitoring methods; construction technologies; structural management; sustainable and safe transport infrastructure; and geomatics and geotechnics. The conference provided an excellent opportunity for leading researchers, representatives of the industrial community, engineers, managers and students to share the latest achievements, discuss recent advances and highlight the current challenges. IMST 2015 attracted over 120 scientists from 24 countries. After rigorous reviewing, over 80 technical papers were accepted for publication in the conference proceedings. On behalf of the organizing committee I would like to thank all the speakers, authors, session chairs and reviewers for their efficient and timely effort. The 2nd International Conference on Innovative Materials, Structures and Technologies was organized by the Faculty of Civil Engineering of Riga Technical University with the support of the Latvia State Research Programme under the grant agreement "INNOVATIVE MATERIALS AND SMART TECHNOLOGIES FOR ENVIRONMENTAL SAFETY, IMATEH". I would like to express sincere gratitude to Juris Smirnovs, Dean of the Faculty of Civil Engineering, and Andris Chate, manager of the Latvia State Research Programme. Finally, I would like to thank all those who helped to make this event happen. Special thanks go to Diana

  20. Injertos de tejido adiposo en cirugía estética mamaria

    Directory of Open Access Journals (Sweden)

    J. Benito-Ruiz

    2013-12-01

    Full Text Available El injerto de tejido adiposo se ha convertido en una de las principales herramientas con la que contamos en Cirugía Plástica y, como no podía ser de otra forma, la mama es el principal órgano diana de nuestra actuación. Desde que introdujimos la técnica en nuestra práctica privada en el año 2009 hemos ido incrementando las indicaciones de su uso. Las tres principales son el aumento mamario, la corrección de defectos y asimetrías y más recientemente el aumento con combinación de ambas técnicas. El aumento mamario con tejido adiposo está indicado en pacientes que quieran incrementar el volumen sin usar implantes. Hay que explicar muy bien a la paciente lo que podemos conseguir en cuanto a volumen y proyección de la mama, además de los problemas potenciales de aparición en las mamografías de quistes y microcalcificaciones. El tejido adiposo, en cambio, es un gran complemento de los implantes mamarios, ya que permite corregir deformidades y asimetrías que con los implantes son más difíciles de resolver. El aumento de mamas combinando ambas técnicas es la consecuencia final y evidente de esta evolución terapéutica, ya que aúna las ventajas de ambas: la firmeza y volumen estables que proporcionan los implantes y la plasticidad que aporta el tejido adiposo para lograr una mayor simetría.

  1. INERA Conference: Vapor Phase Technologies for Metal Oxide and Carbon Nanostructures

    International Nuclear Information System (INIS)

    2016-01-01

    We are pleased to introduce the Proceedings of the Conference “Vapor Phase Technologies for Metal Oxide and Carbon Nanostructures” (6 th to 8 th of July 2016, Velingrad, Bulgaria) organized by the Institute of Solid State Physics, Bulgarian Academy of Sciences in the frames of the Project INERA: “Research and Innovation Capacity Strengthening of ISSP-BAS in Multifunctional Nanostructures” REGPOT-2012-2013-1 NMP (http://www.inera.org). Participants from 7 different countries delivered 10 invited lectures, 16 oral and 26 poster presentations, contributing in 7 different topics. Papers submitted for publication in the Proceedings were refereed according to the standards of the Journal of Physics: Conference Series and the accepted ones illustrate the diversity and the high quality of the contributions. The Conference offered good opportunities for many interesting discussions and ample exchange of ideas between the participants. It became also a meeting point where INERA partners could plan their future collaboration and joint projects. A significant factor for the success of the Conference was the conference venue - the beautiful spa resort Velingrad located 130 km from Sofia in the western part of the Rhodope Mountains. It is one of the leading “balneological” resorts in the Balkans with its ninety mineral water springs suitable for treatment of a wide range of diseases. The participants enjoyed also the rich social program, in particular the guided trip to the excavation site Dorkovo, one of the milestones marking the beginning of the Pliocene epoch in Eastern Europe. The proceedings of conferences and workshops organized in the frames of INERA Project are regularly published by the Journal of Physics: Conference Series. We are grateful to the Journal's staff for the continuous support. Managing Editor: Diana Nesheva Co-editors: Hassan Chamati, Julia Genova, Kostadinka Gesheva, Tatyana Ivanova, Albena Paskaleva and Anna Szekeres (paper)

  2. Protocolo de actuación frente a situaciones conflictivas con los ciudadanos en centros de atención primaria Action protocol against conflictive situations with citizens in primary care centres

    Directory of Open Access Journals (Sweden)

    Coral Sainz Pinós

    2011-03-01

    Full Text Available Según la Organización Internacional de Trabajo (OIT, el 25% de la violencia en el trabajo se produce en el sector sanitario, debido al estrecho contacto con usuarios. Por este motivo, mediante la elaboración de un protocolo y en cumplimiento de la Orden 212/2004, de 4 de Marzo, del Consejero de Sanidad y Consumo, el presente artículo pretende establecer las pautas de actuación que deben llevar a cabo el trabajador, su mando y el resto de instancias implicadas de un centro de atención primaria, ante una situación conflictiva con los ciudadanos (pacientes, familiares y acompañantes de los mismos, en el que medie cualquier tipo de agresión verbal, física o psíquica. La población diana de este protocolo son el trabajador expuesto y todos los usuarios del sistema sanitario. Con esto, se pretende mejorar las condiciones de seguridad y salud de los trabajadores del ámbito sanitario.According to the International Labour Organization (ILO, 25% of workplace violence occurs in the health sector, due to close contact with customers. By developing a protocol and in compliance with the Order 212/2004, 4 March , Health Advisor, this article aims to establish guidelines for action to be carried out by the worker, his boss and all other employees involved in a conflictive situation in a primary care center when in contact with citizens (patients, family members , in which there is any type of verbal, physical or mental aggression. The target population of this protocol are exposed workers and all users of the health system. This protocol aims to improve safety and health conditions in health sector workers.

  3. The real new economy.

    Science.gov (United States)

    Farrell, Diana

    2003-10-01

    During the soar-and-swoon days of the late 1990s, many people believed that information technology, and the Internet in particular, were "changing everything" in business. A fundamental change did happen in the 1990s, but it was less about technology than about competition. Under director Diana Farrell, the McKinsey Global Institute has conducted an extensive study of productivity and its connection to corporate IT spending and use during that period. The study revealed that information technology is important--but not central--to the fate of industries and individual companies. So if information technology was not the primary factor in the productivity surge, what was? The study points to competition and innovation. In those industries that saw increases in competitive intensity, managers were forced to innovate aggressively to protect their revenues and profits. Those innovations--in products, business practices, and technology--led to the gains in productivity. In fact, a critical dynamic of the new economy--the real new economy--is the virtuous cycle of competition, innovation, and productivity growth. Managers can innovate in many ways, but during the 1990s, information technology was a particularly powerful tool, for three reasons: First, IT enabled the development of attractive new products and efficient new business processes. Second, it facilitated the rapid industrywide diffusion of innovations. And third, it exhibited strong scale economies--its benefits multiplied rapidly as its use expanded. This article reveals surprising data on how various industries in the United States and Europe were affected by competition, innovation, and information technology in the 1990s and offers insights about how managers can get more from their IT investments.

  4. Microangiopatía trombótica secundaria y eculizumab: una opción terapéutica razonable

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    Elena Román

    2017-09-01

    Full Text Available El conocimiento del papel del complemento en la patogenia del síndrome hemolítico urémico atípico y otras microangiopatías trombóticas (MAT ha fomentado el desarrollo de la terapia anticomplemento con eculizumab más allá de su indicación original en la hemoglobinuria paroxística nocturna y en el síndrome hemolítico urémico atípico. La evidencia científica demuestra un estrecho límite entre MAT primarias y secundarias con activación del complemento subyacente en ambas. Por ello, el control del complemento se convierte en una diana terapéutica. El uso de eculizumab en MAT secundarias contempla 2 escenarios: diagnóstico diferencial difícil entre MAT primaria y secundaria (incluidos cuadros clínicos incompletos o daño por complemento en procesos distintos, donde se demuestra la eficacia del tratamiento. Esta revisión es una síntesis de la evidencia científica sobre el papel de la activación del complemento en la fisiopatología de las MAT secundarias y la eficacia de la terapia anticomplemento en MAT asociadas a embarazo, fármacos, trasplante, rechazo humoral, enfermedades sistémicas y glomerulonefritis. La experiencia es aún limitada, pero la respuesta a eculizumab en pacientes con MAT secundarias graves y refractarias al tratamiento convencional abre una puerta a la investigación de la terapia anticomplemento como nueva opción terapéutica.

  5. Adherencia al tratamiento hipotensor y presencia de disfunción sexual

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    Sady R. Cortés Pérez

    2016-01-01

    Full Text Available Introducción: La no adherencia al tratamiento hipotensor es un problema reconocido y estudiado. La aparición de reacciones adversas es causa frecuente, pero el papel de las disfunciones sexuales no está bien investigado.Objetivo: Describir el comportamiento de la adherencia al tratamiento hipotensor y su relación con la aparición de trastornos sexuales.Método: Se realizó un estudio descriptivo prospectivo con 102 pacientes de 2 consultorios del Policlínico XX Aniversario de Santa Clara. Se les aplicó una encuesta donde se definieron las variables sociodemográficas, las enfermedades concomitantes, la lesión de órganos diana y el tratamiento hipotensor. Se empleó la prueba de Morisky-Green-Levine enriquecida, para evaluar la adherencia al tratamiento. Se ahondó en las reacciones adversas y especialmente en los trastornos sexuales.Resultados: Se encontró que un 45,1 % (46 de los 102 pacientes no se adhería a la terapéutica prescrita. El abandono por reacciones adversas 45 (97,8 % fue la principal causa. No hubo diferencias en la adherencia al tratamiento entre sexos, ni entre grupos de edad. Las reacciones adversas más detectadas fueron decaimiento (49 %, disfunciones sexuales (39,2 %, cefalea (39,2 % e hipotensión (39,2 %.Conclusiones: La cifra de pacientes hipertensos sin adherencia al tratamiento farmacológico es muy alta, sin relación con el sexo o la edad. La aparición de trastornos sexuales es una de las reacciones adversas que la causan.

  6. Comportamiento de las urgencias y emergencias hipertensivas en un centro de diagnóstico integral, Venezuela

    Directory of Open Access Journals (Sweden)

    María Caridad Fonseca González

    2015-11-01

    Full Text Available Se realizó un estudio descriptivo transversal, en el Centro de Diagnóstico Integral Mópia III de la Parroquia Santa Teresa del Tuy, municipio Independencia, Estado Miranda, Venezuela; con el objetivo de caracterizar el comportamiento de las urgencias y emergencias médicas en el periodo comprendido entre julio de 2006 y julio de 2007, para lo cual se tuvieron en cuenta las variables: edad, sexo, raza, emergencias más frecuentes presentadas, antecedentes patológicos personales y familiares, complicaciones anteriores con daño orgánico y secuela por su enfermedad de base; obteniéndose como resultado que las urgencias y emergencias hipertensivas predominaron en los grupos de edades de 50-64 años; el sexo femenino y la raza negra estuvieron en más proporción; la mayor frecuencia fue de patologías cerebrales; en cuanto a definición de los criterios de emergencia, la hipertensión arterial fue más común, tanto en los antecedentes patológicos personales como familiares. Las complicaciones que con anterioridad sucedieron y dejaron secuelas en órganos dianas fueron las cardiovasculares, insuficiencia renal crónica y el déficit motor neurológico. Como recomendación se sugirió incentivar estudios científicos de índole diversa para enriquecer el arsenal medico estadístico de las urgencias y emergencias hipertensivas y profundizar así en la prevalencia e incidencia de las mismas, y otras patologías y sus peculiaridades, en la nación bolivariana.

  7. METODOLOGÍA Y LOGÍSTICA DE CAMPO DE UN ESTUDIO MULTINIVEL SOBRE LA INFLUENCIA EN ESPAÑA DE LAS CARACTERÍSTICAS MEDIOAMBIENTALES EN LA SALUD MENTAL DE POBLACIÓN AUTÓCTONA Y ECUATORIANA INMIGRANTE

    Directory of Open Access Journals (Sweden)

    Débora Álvarez-del Arco

    2009-01-01

    Full Text Available Se realizó una investigación multinivel sobre el impacto de las características ambientales de la zona de residencia en la salud mental de población autóctona e inmigrante. El objetivo de este artículo es describir el planteamiento metodológico de la investigación, el trabajo de campo, las tasas de respuesta correspondientes y discutir el diseño metodológico y las dificultades derivadas de su puesta en práctica. Los datos individuales se obtuvieron aplicando un cuestionario estructurado de aproximadamente 40 minutos, mediante entrevista domiciliaria a personas españolas y ecuatorianas de 18 a 55 años. El trabajo se realizó de septiembre de 2006 a enero de 2007 en una muestra estimada de 1.186 personas equiparada por sexo y nacionalidad, obtenida aleatoriamente de los Padrones Municipales de 33 áreas (municipios o barrios de Madrid, Alicante, Almería y Murcia, seleccionadas según criterios de densidad étnica y socioeconómicos. Previamente se realizó un estudio piloto (n=113Los indicadores sociodemográficos de las áreas se obtuvieron a partir de fuentes secundarias. Se entrevistó a 1.144 personas (96%. La tasa de respuesta global fue del 61%, superior entre ecuatorianos (69%, colectivo que presentó más problemas de localización (34%. Las negativas a colaborar fueron más altas entre españoles (21%. Se concluye que en este tipo de estudios sería conveniente revisar las estrategias de muestreo para combinar criterios de eficiencia con la necesidad de obtener una muestra representativa de la población diana. Se constata la dificultad de obtener datos inframunicipales de integración social.

  8. Beyond offshoring: assess your company's global potential.

    Science.gov (United States)

    Farrell, Diana

    2004-12-01

    In the past few years, companies have become aware that they can slash costs by offshoring: moving jobs to lower-wage locations. But this practice is just the tip of the iceberg in terms of how globalization can transform industries, according to research by the McKinsey Global Institute (MGI). The institute's yearlong study suggests that by streamlining their production processes and supply chains globally, rather than just nationally or regionally, companies can lower their costs-as we've seen in the consumer-electronics and PC industries. Companies can save as much as 70% of their total costs through globalization--50% from offshoring, 5% from training and business-task redesign, and 15% from process improvements. But they don't have to stop there. The cost reductions make it possible to lower prices and expand into new markets, attracting whole new classes of customers. To date, however, few businesses have recognized the full scope of performance improvements that globalization makes possible, much less developed sound strategies for capturing those opportunities. In this article, Diana Farrell, director of MGI, offers a step-by-step approach to doing both things. Among her suggestions: Assess where your industry falls along the globalization spectrum, because not all sectors of the economy face the same challenges and opportunities at the same time. Also, pay attention to production, regulatory, and organizational barriers to globalization. If any of these can be changed, size up the cost-saving (and revenue-generating) opportunities that will emerge for your company as a result of those changes. Farrell also defines the five stages of globalization-market entry, product specialization, value chain disaggregation, value chain reengineering, and the creation of new markets-and notes the different levers for cutting costs and creating value that companies can use in each phase.

  9. BioMagResBank database with sets of experimental NMR constraints corresponding to the structures of over 1400 biomolecules deposited in the Protein Data Bank

    International Nuclear Information System (INIS)

    Doreleijers, Jurgen F.; Mading, Steve; Maziuk, Dimitri; Sojourner, Kassandra; Yin Lei; Zhu Jun; Markley, John L.; Ulrich, Eldon L.

    2003-01-01

    Experimental constraints associated with NMR structures are available from the Protein Data Bank (PDB) in the form of 'Magnetic Resonance' (MR) files. These files contain multiple types of data concatenated without boundary markers and are difficult to use for further research. Reported here are the results of a project initiated to annotate, archive, and disseminate these data to the research community from a searchable resource in a uniform format. The MR files from a set of 1410 NMR structures were analyzed and their original constituent data blocks annotated as to data type using a semi-automated protocol. A new software program called Wattos was then used to parse and archive the data in a relational database. From the total number of MR file blocks annotated as constraints, it proved possible to parse 84% (3337/3975). The constraint lists that were parsed correspond to three data types (2511 distance, 788 dihedral angle, and 38 residual dipolar couplings lists) from the three most popular software packages used in NMR structure determination: XPLOR/CNS (2520 lists), DISCOVER (412 lists), and DYANA/DIANA (405 lists). These constraints were then mapped to a developmental version of the BioMagResBank (BMRB) data model. A total of 31 data types originating from 16 programs have been classified, with the NOE distance constraint being the most commonly observed. The results serve as a model for the development of standards for NMR constraint deposition in computer-readable form. The constraints are updated regularly and are available from the BMRB web site (http://www.bmrb.wisc.edu)

  10. Solution structure of human intestinal fatty acid binding protein: Implications for ligand entry and exit

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Fengli [Boston University School of Medicine, Department of Biophysics (United States); Luecke, Christian [Johann Wolfgang Goethe-Universitaet (Germany); Baier, Leslie J. [NIDDK, NIH, Phoenix Epidemiology and Clinical Research Branch (United States); Sacchettini, James C. [Texas A and M University, Department of Biochemistry and Biophysics (United States); Hamilton, James A. [Boston University School of Medicine, Department of Biophysics (United States)

    1997-04-15

    The human intestinal fatty acid binding protein (I-FABP) is a small (131 amino acids) protein which binds dietary long-chain fatty acids in the cytosol of enterocytes. Recently, an alanine to threonine substitution at position 54 in I-FABP has been identified which affects fatty acid binding and transport, and is associated with the development of insulin resistance in several populations including Mexican-Americans and Pima Indians. To investigate the molecular basis of the binding properties of I-FABP, the 3D solution structure of the more common form of human I-FABP (Ala54) was studied by multidimensional NMR spectroscopy.Recombinant I-FABP was expressed from E. coli in the presence and absence of 15N-enriched media. The sequential assignments for non-delipidated I-FABP were completed by using 2D homonuclear spectra (COSY, TOCSY and NOESY) and 3D heteronuclear spectra(NOESY-HMQC and TOCSY-HMQC). The tertiary structure of human I-FABP was calculated by using the distance geometry program DIANA based on 2519 distance constraints obtained from the NMR data. Subsequent energy minimization was carried out by using the program SYBYL in the presence of distance constraints. The conformation of human I-FABP consists of 10 antiparallel {beta}-strands which form two nearly orthogonal {beta}-sheets of five strands each, and two short {alpha}-helices that connect the {beta}-strands A and B. The interior of the protein consists of a water-filled cavity between the two {beta}-sheets. The NMR solution structure of human I-FABP is similar to the crystal structure of rat I-FABP.The NMR results show significant conformational variability of certain backbone segments around the postulated portal region for the entry and exit of fatty acid ligand.

  11. Pricing products: juxtaposing affordability with quality appeal.

    Science.gov (United States)

    1984-01-01

    Choosing appropriate product prices is 1 of the most crucial steps in creating an effective contraceptive social marketing (CSM) sales campaign. The Social Marketing Forum conducted an informal survey of social marketing project managers, international contractors, and marketing consultants to determine how CSM programs cope with pricing problems and ways to circumvent some obstacles. According to Diana Altman, a family planning consultant, low prices that make products available to needy individuals are more important than the program's self sufficiency, yet if prices are too low, consumers think the products were unusable in the US and thus were dumped on local markets. Other key factors include commercial competition, spiraling inflation rates, and problems with rising prices and retailer/distributor margins. A sampling of per capita gross national products indicates the poverty level of most CSM projects' target market. Consequently, CSM projects must set low pices, regardless of program operating costs. The goal often is to increase the demand and availability for contraceptives. The fact that social marketing products must pass through retail networks to reach consumers complicates the pricing equation. To deal with the problem, India's Nirodh program gives a 25% margin to distributors/wholesalers, compared to 6% offered on most other goods. Retailers also receive a 25% margin, more than double the commercial rate. Once prices are set, increases pose hazards. Local government approval often is a prerequisite and can require lengthy negotiations. Market studies remain a valuable approach to effective pricing, according to PNA's Mallamad and other research consultants. They cite such effective research strategies as test marketing products and asking consumers how prices affect buying habits. Further, CSM projects can jump over some pricing hurdles through creative marketing. An effective pricing strategy alone cannot produce a successful CSM program. Pricing

  12. The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach

    Directory of Open Access Journals (Sweden)

    Crisan D

    2015-09-01

    Full Text Available Diana Crisan,1 Iulia Roman,2 Maria Crisan,2 Karin Scharffetter-Kochanek,1 Radu Badea31Clinic of Dermatology and Allergology, University Clinic Ulm, Ulm, Germany; 2Clinic of Dermatology and Venereology, 3Department of Clinical Imaging Ultrasound, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaBackground: Imagistic methods stand as modern, non-invasive, and objective means of assessing the impact of topical cutaneous therapies.Objective: This study focuses on the evaluation, by high-frequency ultrasound, of the cutaneous changes induced by topical use of a vitamin C complex at facial level.Methods: A vitamin C-based solution/Placebo moisturizer cream was applied at facial level of 60 healthy female subjects according to a predetermined protocol. Ultrasonographic images (Dermascan C, 20 MHz were taken from zygomatic level initially, at 40 and 60 days after therapy. The following parameters were assessed for every subject: thickness of the epidermis and dermis (mm, the number of low (LEP, medium (MEP, high echogenic pixels (HEP, and the number of LEP in the upper dermis/lower dermis (LEPs/LEPi.Results: LEP decreased significantly in all age categories during and after therapy, but especially in the first 2 age intervals, up to the age of 50 (P=0.0001. MEP and HEP, pixel categories that quantify protein synthesis also had an age-dependent evolution in the study, increasing significantly in all age categories but most of all in the first age interval (P=0.002. Our ultrasonographic data suggest that collagen synthesis increased significantly after topical vitamin C therapy, and is responsible for the increase in MEP and HEP and consequent decrease of the LEP.Conclusion: Our study shows that topically applied vitamin C is highly efficient as a rejuvenation therapy, inducing significant collagen synthesis in all age groups with minimal side effects.Keywords: ascorbic acid, rejuvenation, ultrasound, collagen synthesis

  13. Radium 223 dichloride for prostate cancer treatment

    Directory of Open Access Journals (Sweden)

    Deshayes E

    2017-09-01

    Full Text Available Emmanuel Deshayes,1,2 Mathieu Roumiguie,3 Constance Thibault,4 Philippe Beuzeboc,5 Florent Cachin,6 Christophe Hennequin,7 Damien Huglo,8 François Rozet,9 Diana Kassab-Chahmi,10 Xavier Rebillard,11 Nadine Houédé1,12 1Radiobiology Unit, INSERM U1194, Institut du Cancer de Montpellier (ICM, 2Department of Nuclear Medicine, Institut du Cancer de Montpellier (ICM, Montpellier, 3Urology Department, Andrology and Renal Transplantation, CHU Rangueil, Toulouse, 4Medical Oncology Department, Hôpital Européen Georges Pompidou, 5Oncology Department, Institut Curie, 6Department of Nuclear Medicine, CHU, Clermont-Ferrand, 7Radiotherapy Department, Hôpital Saint Louis, Paris, 8Department of Nuclear Medicine, CHRU, Lille, 9Urology Department, Institut Mutualiste Montsouris, 10Intergroupe coopérateur francophone de recherche en onco-urologie, Paris, 11Urology Department, Clinique BeauSoleil, Montpellier, 12Medical Oncology Department, Institut de Cancérologie du Gard – CHU Caremeau, Nîmes, France Abstract: Prostate cancer is the most common malignant disease in men. Several therapeutic agents have been approved during the last 10 years. Among them, radium-223 dichloride (Xofigo® is a radioactive isotope that induces irreversible DNA double-strand breaks and consequently tumor cell death. Radium-223 dichloride is a calcium-mimetic agent that specifically targets bone lesions. Radium-223 dichloride has been approved for the treatment of metastatic castration-resistant prostate cancer with symptomatic bone metastases, without known visceral metastases. In this review, first we summarize the interplay between prostate tumor cells and bone microenvironment; then, we discuss radium-223 dichloride mechanism of action and present the results of the available clinical trials and future developments for this new drug. Keywords: bone metastasis, mCRPC, mechanism, drug, agents, development 

  14. Synanthropy of Sarcophagidae (Diptera in La Pintada, Antioquia-Colombia

    Directory of Open Access Journals (Sweden)

    Daniela Yepes-Gaurisas

    2013-09-01

    Full Text Available Recently, populations of flies have increased in numbers given the elevated levels of organic matter waste produced by anthropic activities and domestication of animals. Such increase represents a worldwide health concern, since flies can be vectors of human diseases. The great variety of feeding and developmental habits of flies of the family Sarcophagidae taking place on animal corpses, feces and decomposed organic matter make them potential vectors of pathogens. Herein, we evaluated the synanthropic index (SI, as well as other ecological aspects of this family, through simultaneous monthly samplings in three areas with different degrees of human disturbance (urban, rural and forest. Each area had four van Someren Rydon traps, each one with a different bait (i.e., human feces, chicken viscera, fish and decomposing onion. Traps were active during 48 hours each month, and specimen collection was made every 12 hours. A total of 7 446 Sarcophagidae individuals were collected (1 275 males and 6 171 females, belonging to 27 species and nine genera. Tricharaea (Sarcophagula canuta (SI=+96.67, Oxysarcodexia taitensis (SI=+93.85, Peckia (Peckia chrysostoma (SI=+90.00 and Tricharaea (Sarcophagula occidua (SI=+88.76 exhibited the highest values of synanthropy index, revealing a strong preference for human settlements. The most abundant species were Oxysarcodexia conclausa (21.80%, Ravinia effrenata (18.67%, Oxysarcodexia bakeri (11.45% and Oxysarcodexia taitensis (10.20%, all of which exhibited preference for urban environments. Additionally, we are reporting seven new records of Sarcophagid flies for Colombia: Oxysarcodexia angrensis, Oxysarcodexia bakeri, Oxysarcodexia diana, Oxysarcodexia similata, Oxysarcodexia timida, Peckia (Peckia pexata and Titanogrypa (Cucullomyia placida.

  15. Adenocarcinoma pulmonar metastásico con evolución favorable al tratamiento con ITK-EGFR en un paciente fumador

    Directory of Open Access Journals (Sweden)

    Joseph Jesús Exebio Jara

    2015-04-01

    Full Text Available Introducción: El cáncer de pulmón es el cáncer con mayor mortalidad en ambos sexos. El esquema de manejo actual del adenocarcinoma pulmonar incluye determinar el estado mutacional del receptor del factor de crecimiento epidérmico (EGFR, por ser la diana para el erlotinib, una terapia biológica. Caso clínico: Varón de 62 años, con hábito tabáquico de alto riesgo oncológico, que debuta con un cuadro de cefalea de un mes de evolución, objetivándose por resonancia magnética tumor cerebral. El diagnóstico inmunohistoquímico post quirúrgico fue adenocarcinoma pulmonar metastásico (TTF-1 (+. La tomografía identificó una lesión en el lóbulo superior derecho del pulmón; no presentaba clínica respiratoria. Al ser positivo para la mutación en el exón 21 del gen EGFR, se inició terapia con erlotinib, siendo bien tolerada por el paciente y manteniendo su estabilidad clínica. El paciente sobrevivió por el lapso de 31 meses posterior a su diagnóstico. Discusión: El tratamiento con erlotinib fue inicialmente indicado en el perfil de una paciente mujer, asiática y no fumadora. La eficacia en los estudios en pacientes con cáncer de pulmón de células no pequeñas evidencia que la sobrevida global es 15,9 meses, muy por debajo del visto en el presente caso.

  16. Dehydration triggers differential microRNA expression in Xenopus laevis brain.

    Science.gov (United States)

    Luu, Bryan E; Storey, Kenneth B

    2015-11-15

    African clawed frogs, Xenopus laevis, although primarily aquatic, have a high tolerance for dehydration, being capable of withstanding the loss of up to 32-35% of total water body water. Recent studies have shown that microRNAs play a role in the response to dehydration by the liver, kidney and ventral skin of X. laevis. MicroRNAs act by modulating the expression of mRNA transcripts, thereby affecting diverse biochemical pathways. In this study, 43 microRNAs were assessed in frog brains comparing control and dehydrated (31.2±0.83% of total body water lost) conditions. MicroRNAs of interest were measured using a modified protocol which employs polyadenylation of microRNAs prior to reverse transcription and qPCR. Twelve microRNAs that showed a significant decrease in expression (to 41-77% of control levels) in brains from dehydrated frogs (xla-miR-15a, -150, -181a, -191, -211, -218, -219b, -30c, -30e, -31, -34a, and -34b) were identified. Genomic analysis showed that the sequences of these dehydration-responsive microRNAs were highly conserved as compared with the comparable microRNAs of mice (91-100%). Suppression of these microRNAs implies that translation of the mRNA transcripts under their control could be enhanced in response to dehydration. Bioinformatic analysis using the DIANA miRPath program (v.2.0) predicted the top two KEGG pathways that these microRNAs collectively regulate: 1. Axon guidance, and 2. Long-term potentiation. Previous studies indicated that suppression of these microRNAs promotes neuroprotective pathways by increasing the expression of brain-derived neurotrophic factor and activating anti-apoptotic pathways. This suggests that similar actions may be triggered in X. laevis brains as a protective response to dehydration. Crown Copyright © 2015. Published by Elsevier B.V. All rights reserved.

  17. Hypertensive crisis: urgency and hypertensive emergency

    Directory of Open Access Journals (Sweden)

    Javier Sobrino Martínez

    2016-12-01

    Full Text Available Resumen Las crisis hipertensivas son un conjunto de situaciones clínicas de variada gravedad y pronóstico. Las diferencias entre urgencias y emergencias hipertensivas radican en la existencia o no de riesgo vital por afectación de órganos diana, más que por los niveles de presión arterial. Las urgencias hipertensivas no suelen comportar riesgo vital inmediato por lo que el tratamiento puede iniciarse, incluso completarse, en el medio extrahospitalario. Las emergencias hipertensivas son situaciones clínicas muy graves que requieren asistencia hospitalaria. Ante un paciente con hipertensión grave, asintomático o con síntomas inespecíficos debe adoptarse una actitud terapéutica prudente. La primera medida será comprobar las cifras de presión arterial con tomas repetidas de la misma y tratar los posibles factores desencadenantes. El objetivo del tratamiento de las urgencias hipertensivas es tanto obtener una reducción de las cifras de presión arterial (al menos un 20% de las cifras basales como evitar reducciones bruscas y/o excesivas de la misma. En las urgencias hipertensivas no deberían utilizarse fármacos de acción rápida por el riesgo de accidentes isquémicos y utilizar fármacos con vida media más larga. El riesgo cardiovascular de estos pacientes es superior al de los hipertensos que no sufren una crisis hipertensiva. En las emergencias hipertensivas la elección del fármaco deberá individualizarse. La vía parenteral es la forma habitual de la administración de fármacos.

  18. An antiaging skin care system containing alpha hydroxy acids and vitamins improves the biomechanical parameters of facial skin

    Directory of Open Access Journals (Sweden)

    Tran D

    2014-12-01

    Full Text Available Diana Tran, Joshua P Townley, Tanya M Barnes, Kerryn A Greive Ego Pharmaceuticals, Braeside, Victoria, Australia Background: The demand for antiaging products has dramatically increased in recent years, driven by an aging population seeking to maintain the appearance of youth. This study investigates the effects of an antiaging skin care system containing alpha hydroxy acids (AHAs in conjunction with vitamins B3, C, and E on the biomechanical parameters of facial skin. Methods: Fifty two volunteers followed an antiaging skin care regimen comprising of cleanser, eye cream, day moisturizer, and night moisturizer for 21 days. Wrinkle depth (Ry and skin roughness (Ra were measured by skin surface profilometry of the crow's feet area, and skin elasticity parameters R2 (gross elasticity, R5 (net elasticity, R6 (viscoelastic portion, and R7 (recovery after deformation were determined for facial skin by cutometer, preapplication and after 7, 14, and 21 days. Volunteers also completed a self-assessment questionnaire. Results: Compared to baseline, Ry and Ra significantly improved by 32.5% (P<0.0001 and 42.9% (P<0.0001, respectively, after 21 days of antiaging skin care treatment. These results were observed by the volunteers with 9 out of 10 discerning an improvement in skin texture and smoothness. Compared to baseline, R2 and R5 significantly increased by 15.2% (P<0.0001 and 12.5% (P=0.0449, respectively, while R6 significantly decreased by 17.7% (P<0.0001 after 21 days. R7 increased by 9.7% after 21 days compared to baseline but this was not significant over this time period. Conclusion: An antiaging skin care system containing AHAs and vitamins significantly improves the biomechanical parameters of the skin including wrinkles and skin texture, as well as elasticity without significant adverse effects. Keywords: alpha hydroxy acids, antiaging, nicotinamide, vitamin C, vitamin E, profilometry, cutometer

  19. Cobertura e inmunorespuesta a la vacunación frente al virus de la hepatitis B en adolescentes de la provincia de Guadalajara

    Directory of Open Access Journals (Sweden)

    Martínez Pérez José A.

    1998-01-01

    Full Text Available FUNDAMENTO. La hepatitis B constituye uno de los mayores problemas de salud a nivel mundial. Una de las medidas para su prevención es la vacunación masiva de los adolescentes. El objetivo de nuestro estudio fue evaluar la cobertura del programa de vacunación sistemática antihepatitis B entre la población de 8º curso de EGB de la provincia de Guadalajara y estudiar la inmunorrespuesta de la misma, relacionándola con otras variables. MÉTODOS. Se trata de un estudio transversal. La cobertura del programa vacunal se estudió en toda la población diana de la provincia. Para el estudio de la inmunorrespuesta se obtuvo una muestra de 338 alumnos, mediante muestreo aleatorio sistemático. Se cuantificaron los títulos de anti-HBs al 6º mes de la tercera dosis, considerándose niveles protectores los iguales o superiores a 10 mU/ml. RESULTADOS. El porcentaje de personas correctamente vacunadas fue del 82,7%. La tasa de seroprotección global fue del 97,5%. El 46,7% de la muestra respondieron con títulos superiores a 1000 mU/ml. Existió relación inversa estadísticamente significativa (p<0,001 entre el nivel de anti-HBs y el de Quetelet. No encontramos diferencias significativas entre los dos sexos al comparar los títulos postvacunales de anti-Hbs CONCLUSIONES. Estimamos satisfactoria la cobertura alcanzada y buena la inmunogenicidad de la vacuna. La obesidad es un factor predictor de baja respuesta a la misma. Esta respuesta no se ve influenciada por el sexo.

  20. Recent Progress in GW-based Methods for Excited-State Calculations of Reduced Dimensional Systems

    Science.gov (United States)

    da Jornada, Felipe H.

    2015-03-01

    Ab initio calculations of excited-state phenomena within the GW and GW-Bethe-Salpeter equation (GW-BSE) approaches allow one to accurately study the electronic and optical properties of various materials, including systems with reduced dimensionality. However, several challenges arise when dealing with complicated nanostructures where the electronic screening is strongly spatially and directionally dependent. In this talk, we discuss some recent developments to address these issues. First, we turn to the slow convergence of quasiparticle energies and exciton binding energies with respect to k-point sampling. This is very effectively dealt with using a new hybrid sampling scheme, which results in savings of several orders of magnitude in computation time. A new ab initio method is also developed to incorporate substrate screening into GW and GW-BSE calculations. These two methods have been applied to mono- and few-layer MoSe2, and yielded strong environmental dependent behaviors in good agreement with experiment. Other issues that arise in confined systems and materials with reduced dimensionality, such as the effect of the Tamm-Dancoff approximation to GW-BSE, and the calculation of non-radiative exciton lifetime, are also addressed. These developments have been efficiently implemented and successfully applied to real systems in an ab initio framework using the BerkeleyGW package. I would like to acknowledge collaborations with Diana Y. Qiu, Steven G. Louie, Meiyue Shao, Chao Yang, and the experimental groups of M. Crommie and F. Wang. This work was supported by Department of Energy under Contract No. DE-AC02-05CH11231 and by National Science Foundation under Grant No. DMR10-1006184.

  1. New procedure to synthesize silver nanoparticles and their interaction with local anesthetics

    Directory of Open Access Journals (Sweden)

    Mocanu A

    2013-10-01

    Full Text Available Aurora Mocanu,1 Roxana Diana Pasca,1 Gheorghe Tomoaia,2 Corina Garbo,1 Petre T Frangopol,1 Ossi Horovitz,1 Maria Tomoaia-Cotisel11Chemical Engineering Department, Babes-Bolyai University, 2Orthopedic Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaAbstract: Silver nanoparticles (AgNPs were prepared in aqueous colloid dispersions by the reduction of Ag+ with glucose in alkaline medium. Tetraethyl orthosilicate and l-asparagine were added as stabilizers of NPs. The AgNPs were characterized, and their interaction with three local anesthetics (procaine, dibucaine, or tetracaine was investigated. Optical spectra show the characteristic absorption band of AgNPs, due to surface plasmon resonance. Modifications in the position and shape of this band reflect the self-assembly of metal NPs mediated by anesthetic molecules and the progress in time of the aggregation process. Zeta-potential measuring was applied in order to characterize the electrostatic stability of the NPs. The size and shape of the AgNPs, as well as the features of the assemblies formed by their association in the presence of anesthetics, were evidenced by transmission electron microscopy images. Atomic force microscopy images showed the characteristics of the films of AgNPs deposited on glass support. The effect of the anesthetics could be described in terms of electrostatic forces between the negatively charged AgNPs and the anesthetic molecules, existing also in their cationic form at the working pH. But also hydrophobic and hydrogen bonding interactions between the coated nanoparticles and anesthetics molecular species should be considered.Keywords: self-assembled nanostructures, UV-vis spectra, TEM, AFM, zeta potential

  2. A review of the neural and behavioral consequences for unitizing emotional and neutral information

    Directory of Open Access Journals (Sweden)

    Brendan eMurray

    2013-05-01

    Full Text Available A special type of association, called a unitization, is formed when pieces of information are encoded as a single representation in memory (e.g., shirt and blue are encoded as a blue shirt; Graf & Schacter, 1989 and typically are later reactivated in memory as a single unit, allowing access to the features of multiple related stimuli at once (Bader et al., 2010; Diana et al., 2011. This review examines the neural processes supporting memory for unitizations and how the emotional content of the material may influence unitization. Although associative binding is typically reliant on hippocampal processes and supported by recollection, the first part of this review will present evidence to suggest that when two items are unitized into a single representation, memory for those bound items may be accomplished on the basis of familiarity and without reliance on the hippocampus. The second part of this review discusses how emotion may affect the processes that give rise to unitizations. Emotional information typically receives a mnemonic benefit over neutral information, but the literature is mixed on whether the presence of emotional information impedes or enhances the associative binding of neutral information (reviewed by Mather, 2007. It has been suggested that the way the emotional and neutral details are related together may be critical to whether the neutral details are enhanced or impeded (Mather, 2007; Mather & Sutherland, 2011. We focus on whether emotional arousal aides or inhibits the creation of a unitized representation, presenting preliminary data and future directions to test empirically the effects of forming and retrieving emotional and neutral unitizations.

  3. Sun-protective behaviors in populations at high risk for skin cancer

    Directory of Open Access Journals (Sweden)

    Diao DY

    2013-12-01

    Full Text Available Diana Y Diao,1 Tim K Lee1,21Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada; 2Cancer Control Research Program, BC Cancer Agency, Vancouver, British Columbia, CanadaAbstract: Over 3 million new cases of skin cancer are diagnosed in the US annually. Melanoma, a subtype of skin cancer that can be fatal if the disease is not detected and treated at an early stage, is the most common cancer for those aged 25–29 years and the second most common cancer in adolescents and young adults aged 15–29 years. The primary carcinogen for the genesis of skin cancers is ultraviolet light from solar radiation and tanning beds. In spite of massive health campaigns to raise public awareness on ultraviolet radiation, sun-protective practices still fall behind. A plausible explanation is the lack of behavioral change in the populations at risk; in this review article, we examine sun-protective behavior in the four high-risk skin cancer groups: skin cancer survivors, individuals with a family history of melanoma, individuals with physical characteristics associated with skin cancer risk, and organ transplantation patients. Findings in the literature demonstrate that increased knowledge and awareness does not consequently translate into behavioral changes in practice. Behavior can differ as a result of different attitudes and beliefs, depending on the population at risk. Thus, intervention should be tailored to the population targeted. A multidisciplinary health team providing consultation and education is required to influence these much needed changes.Keywords: skin cancer, melanoma, risk, prevention, behaviour

  4. New and extended-action treatments in the management of ADHD: a critical appraisal of lisdexamfetamine in adults and children

    Directory of Open Access Journals (Sweden)

    Diana Domnitei

    2010-05-01

    Full Text Available Diana Domnitei, Vishal MadaanDepartment of Psychiatry, Creighton University Medical Center, Omaha, NE, USAAbstract: Treatment guidelines from the American Academy of Child and Adolescent Psychiatry and the American Academy of Pediatrics state that stimulant medications have the most evidence for safety and efficacy in the treatment of childhood attention deficit hyperactivity disorder (ADHD. Longer-acting stimulants are thus considered as first-line for management of ADHD symptoms. Over the years, concerns about the abuse potential of stimulants have led to the development of alternative formulations of these agents. One such recent development, lisdexamfetamine (LDX was FDA approved for treating ADHD in children in early 2007 and in adults in early 2008. LDX is a prodrug, which when orally ingested, is converted to l-lysine and active d-amphetamine, which is responsible for its therapeutic activity. This unique formulation may lead to a possible reduction of the abuse potential, by bypassing the first-pass metabolism. In fact, a statistically significant difference for the ‘liking’ effects on the Drug Questionnaire Response has been reported with intravenous LDX compared to d-amphetamine. LDX appears to have an efficacy and tolerability profile comparable to other extended-release stimulant formulations used to treat ADHD, but reduced potential for abuse-related liking effects when compared to equivalent amounts of immediate-release d-amphetamine. The most common adverse events include decreased appetite, insomnia, upper abdominal pain, headache, irritability, weight loss, and nausea.Keywords: lisdexamfetamine, attention deficit hyperactivity disorder, adults, children

  5. Nanoinformatics: a new area of research in nanomedicine

    Directory of Open Access Journals (Sweden)

    Maojo V

    2012-07-01

    Full Text Available Victor Maojo,1 Martin Fritts,2,3 Diana de la Iglesia,1 Raul E Cachau,4 Miguel Garcia-Remesal,1 Joyce A Mitchell,5 Casimir Kulikowski61Biomedical Informatics Group, Departamento de Inteligencia Artificial, Facultad de Informática, Universidad Politécnica de Madrid, Spain; 2SAIC-Frederick Inc, National Cancer Institute at Frederick, Frederick, Maryland, 3National Institute of Standards and Technology, Gaithersburg, Maryland, 4Advanced Biomedical Computing Center, National Cancer Institute, SAIC-Frederick Inc, Frederick, Maryland, 5Department of Biomedical Informatics, University of Utah, Utah, 6Department of Computer Science, Rutgers, The State University of New Jersey, New Jersey, USAAbstract: Over a decade ago, nanotechnologists began research on applications of nanomaterials for medicine. This research has revealed a wide range of different challenges, as well as many opportunities. Some of these challenges are strongly related to informatics issues, dealing, for instance, with the management and integration of heterogeneous information, defining nomenclatures, taxonomies and classifications for various types of nanomaterials, and research on new modeling and simulation techniques for nanoparticles. Nanoinformatics has recently emerged in the USA and Europe to address these issues. In this paper, we present a review of nanoinformatics, describing its origins, the problems it addresses, areas of interest, and examples of current research initiatives and informatics resources. We suggest that nanoinformatics could accelerate research and development in nanomedicine, as has occurred in the past in other fields. For instance, biomedical informatics served as a fundamental catalyst for the Human Genome Project, and other genomic and –omics projects, as well as the translational efforts that link resulting molecular-level research to clinical problems and findings.Keywords: biomedical informatics, nanomedicine, nanotoxicology, ontologies

  6. Long non-coding RNA TUG1 acts as a miR-26a sponge in human glioma cells.

    Science.gov (United States)

    Li, Jun; An, Gang; Zhang, Meng; Ma, Qingfang

    2016-09-02

    Long non-coding RNA taurine upregulated gene 1 (TUG1) acts as an important regulator in cancer pathogenesis; however, its functional mechanism in glioma development remains unclear. This study aims to explore the potential function of TUG1 in glioma by sponging miR-26a. The expression of TUG1, miR-26a, and phosphatase and tensin homolog (PTEN) in 20 paired glioma tissues was detected by quantitative real-time PCR and subjected to correlation analysis. Bioinformatics analysis was performed by using DIANA Tools. Abnormal TUG1 expression was conducted in two glioma cells to analyze its regulation on miR-26a and PTEN using real-time PCR, western blot, and luciferase reporter assay. TUG1 expression was confirmed to be upregulated in glioma tissues, and showed an inverse correlation with downregulated miR-26a. TUG1 could negatively regulate the expression of miR-26a in glioma cells. The bioinformatics prediction revealed putative miR-26a binding sites within TUG1 transcripts. Further experiments demonstrated the positive regulation of TUG1 on the miR-26a target, PTEN, wherein TUG1 could inhibit the negative regulation of miR-26a on PTEN by binding its 3'UTR. Additionally, the expression of PTEN was also upregulated in glioma tissues, showing a positive or negative correlation with TUG1 or miR-26a, respectively. TUG1 could serve as a miR-26a sponge in human glioma cells, contributing to the upregulation of PTEN. This study revealed a new TUG1/miR-26a/PTEN regulatory mechanism and provided a further understanding of the tumor-suppressive role of TUG1 in glioma development. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Culturally relevant science: An approach to math science education for Hispanics. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz de Montellano, B.

    1996-11-14

    As planned a letter was sent out to 17 teachers who had participated in a Summer 1994 workshop on ``Culturally Relevant Science for Hispanics`` at Michigan State. These teachers were supposed to have spent the intervening time developing lesson plans and curricula. The letter requested a report of any activities undertaken and copies of lesson plans and materials developed by February 1996 with a stipend of $400 for satisfactory reports. It was a disappointment to only get 9 responses and not all of them demonstrating a satisfactory level of activity. Diana Marinez, Dean of Science at Texas A and M University, Corpus Christi, who is the other developer of this curriculum and the author reviewed the submitted materials and chose those showing the most promise to be invited to participate in the Summer Writing Workshop. Spring of 1996 and particularly in May--June, the author wrote a partial first draft of a companion volume for the teacher`s manual which would provide a rationale for doing culturally relevant science, present the cultural and the scientific background that teachers would need in order to be able to teach. One of the goals of this curriculum is that it should be off-the-shelf ready to teach and that teachers would not have to do extra research to encourage its adoption. The outline of the book is appendix 1. The Writing Workshop was held at Texas A and M University, Corpus Christi from July 14 to July 27, 1996. Participating teachers chose topics that they were interested in developing and wrote first drafts. These were distributed to all participants and critiqued by the workshop directors before being rewritten. Some teachers were more productive than others depending on their science background. In total an impressive number of lesson plans were written. These lesson plans are listed in Appendix 3. Appendix 4 is a sample lesson. Work still needs to be done on both the source book and the teachers` manual.

  8. Mejora de defensas antioxidantes mediante ejercicio aeróbico en mujeres con síndrome metabólico

    Directory of Open Access Journals (Sweden)

    Manuel Rosety-Rodríguez

    2012-02-01

    Full Text Available En la actualidad se acepta que el daño oxidativo juega un papel esencial en la patogénesis del síndrome metabólico. Estudios recientes proponen al daño oxidativo como diana terapéutica frente al síndrome metabólico. Precisamente nuestro objetivo fue mejorar el estatus total antioxidante (TAS de mujeres con síndrome metabólico mediante ejercicio aeróbico. Participaron voluntariamente 100 mujeres con síndrome metabólico de acuerdo con los criterios del National Cholesterol Educational Program (Adult-Treatment-Panel-III distribuidas aleatoriamente en grupo experimental (n = 60 y control (n = 40. El grupo experimental desarrolló un programa de entrenamiento aeróbico sobre tapiz rodante de intensidad ligera/moderada de 12 semanas (5 sesiones/semana. La determinación del TAS plasmático se realizó mediante espectrofotometría utilizando kits comercializados por Randox Lab. Este protocolo fue aprobado por un Comité de Etica Institucional. Tras completar el programa de entrenamiento se incrementó significativamente el TAS (0.79 ± 0.05 vs.1.01 ± 0.03 mmol/l; p = 0.027. No hubo cambios en grupo control. El ejercicio aeróbico de intensidad ligera/moderada aumenta las defensas antioxidantes en mujeres con síndrome metabólico. Son necesarios futuros estudios longitudinales para conocer su impacto en la evolución clínica.

  9. Silencing of the major family of NBS-LRR-encoding genes in lettuce results in the loss of multiple resistance specificities.

    Science.gov (United States)

    Wroblewski, Tadeusz; Piskurewicz, Urszula; Tomczak, Anna; Ochoa, Oswaldo; Michelmore, Richard W

    2007-09-01

    The RGC2 gene cluster in lettuce (Lactuca sativa) is one of the largest known families of genes encoding nucleotide binding site-leucine-rich repeat (NBS-LRR) proteins. One of its members, RGC2B, encodes Dm3 which determines resistance to downy mildew caused by the oomycete Bremia lactucae carrying the cognate avirulence gene, Avr3. We developed an efficient strategy for analysis of this large family of low expressed genes using post-transcriptional gene silencing (PTGS). We transformed lettuce cv. Diana (carrying Dm3) using chimeric gene constructs designed to simultaneously silence RGC2B and the GUS reporter gene via the production of interfering hairpin RNA (ihpRNA). Transient assays of GUS expression in leaves accurately predicted silencing of both genes and were subsequently used to assay silencing in transgenic T(1) plants and their offspring. Levels of mRNA were reduced not only for RGC2B but also for all seven diverse RGC2 family members tested. We then used the same strategy to show that the resistance specificity encoded by the genetically defined Dm18 locus in lettuce cv. Mariska is the result of two resistance specificities, only one of which was silenced by ihpRNA derived from RGC2B. Analysis of progeny from crosses between transgenic, silenced tester stocks and lettuce accessions carrying other resistance genes previously mapped to the RGC2 locus indicated that two additional resistance specificities to B. lactucae, Dm14 and Dm16, as well as resistance to lettuce root aphid (Pemphigus bursarius L.), Ra, are encoded by RGC2 family members.

  10. Papel de la vía de señalización del TWEAK/Fn14 en la nefritis lúpica y otros escenarios clínicos

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    Diego A. González-Sánchez

    2017-03-01

    Full Text Available El conocimiento de las vías de señalización implicadas en distintas enfermedades ha permitido avances en el entendimiento del modelo fisiopatológico, diagnóstico y terapéutico de varias enfermedades inflamatorias y autoinmunes. El lupus eritematoso sistémico es una enfermedad autoinmune ampliamente estudiada, la cual puede afectar múltiples órganos, con un importante impacto en la morbimortalidad cuando existe afectación renal. Durante los últimos 10 años ha aumentado el interés sobre el papel de la vía de señalización del TWEAK/Fn14 en la nefritis lúpica al igual que en otros escenarios clínicos. Este artículo realiza una revisión de la literatura del papel de esta vía dentro de la nefritis lúpica, recalca la importancia del TWEAK en orina (uTWEAK como biomarcador de la enfermedad, indica los resultados favorables obtenidos en la inhibición de la vía del TWEAK/Fn14 como diana terapéutica en modelos experimentales animales publicados en la literatura y muestra su posible utilidad en otros escenarios. Los diferentes ensayos clínicos en curso y otras futuras investigaciones darán un mejor panorama en cuanto al beneficio real del bloqueo de esta vía en el curso clínico de estas enfermedades.

  11. PREFACE: 17th International School on Condensed Matter Physics (ISCMP): Open Problems in Condensed Matter Physics, Biomedical Physics and their Applications

    Science.gov (United States)

    Dimova-Malinovska, Doriana; Nesheva, Diana; Pecheva, Emilia; Petrov, Alexander G.; Primatarowa, Marina T.

    2012-12-01

    We are pleased to introduce the Proceedings of the 17th International School on Condensed Matter Physics: Open Problems in Condensed Matter Physics, Biomedical Physics and their Applications, organized by the Institute of Solid State Physics of the Bulgarian Academy of Sciences. The Chairman of the School was Professor Alexander G Petrov. Like prior events, the School took place in the beautiful Black Sea resort of Saints Constantine and Helena near Varna, going back to the refurbished facilities of the Panorama hotel. Participants from 17 different countries delivered 31 invited lecturers and 78 posters, contributing through three sessions of poster presentations. Papers submitted to the Proceedings were refereed according to the high standards of the Journal of Physics: Conference Series and the accepted papers illustrate the diversity and the high level of the contributions. Not least significant factor for the success of the 17 ISCMP was the social program, both the organized events (Welcome and Farewell Parties) and the variety of pleasant local restaurants and beaches. Visits to the Archaeological Museum (rich in valuable gold treasures of the ancient Thracian culture) and to the famous rock monastery Aladja were organized for the participants from the Varna Municipality. These Proceedings are published for the second time by the Journal of Physics: Conference Series. We are grateful to the Journal's staff for supporting this idea. The Committee decided that the next event will take place again in Saints Constantine and Helena, 1-5 September 2014. It will be entitled: Challenges of the Nanoscale Science: Theory, Materials and Applications. Doriana Dimova-Malinovska, Diana Nesheva, Emilia Pecheva, Alexander G Petrov and Marina T Primatarowa Editors

  12. Epilepsy and homicide

    Directory of Open Access Journals (Sweden)

    Pandya NS

    2013-05-01

    Full Text Available Neil S Pandya,1 Mirna Vrbancic,2 Lady Diana Ladino,3,4 José F Téllez-Zenteno31Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; 2Department of Clinical Health Psychology, Royal University Hospital, Saskatoon, Saskatchewan, Canada; 3Division of Neurology, Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; 4Department of Neurology, College of Medicine, University of Antioquia, Medellin, ColombiaPurpose: We report the rare case of a patient with intractable epilepsy and escalating aggression, resulting in murder, who had complete resolution of her seizures and explosive behavior following a right temporal lobectomy.Patients and methods: We searched the available literature from 1880 to 2013 for cases of epilepsy being used as a court defense for murder and collected information regarding the final sentencing outcomes. We selected 15 papers with a total of 50 homicides.Results: We describe the case of a 47-year-old woman with drug-resistant right temporal epilepsy who developed increasing emotional lability, outbursts of anger and escalating violent behavior culminating in a violent murder. The patient was imprisoned while awaiting trial. In the interim, she underwent a successful temporal lobectomy with full resolution of seizures, interictal rage and aggressive behaviors. After the surgery, her charges were downgraded and she was transferred to a psychiatric facility.Conclusion: The aggressive behavior associated with epilepsy has been described in the literature for over a century. A link between epilepsy and aggression has been disproportionally emphasized. These patients share some common characteristics: they are usually young men with a long history of epilepsy and lower than average intelligence. The violent act is postictal, sudden-onset, more likely to occur after a cluster of seizures and is usually related with alcohol abuse.Keywords: aggression, crime, epilepsy

  13. Managing the pediatric patient with celiac disease: a multidisciplinary approach

    Directory of Open Access Journals (Sweden)

    Isaac DM

    2016-10-01

    Full Text Available Daniela Migliarese Isaac,1 Jessica Wu,2 Diana R Mager,3,4 Justine M Turner1 1Department of Pediatric Gastroenterology and Nutrition, Faculty of Medicine and Dentistry, University of Alberta; 2Alberta Health Services–Child Health Nutrition Services, Stollery Children’s Hospital; 3Department of Agriculture, Food and Nutritional Science; 4Department of Pediatrics, University of Alberta, Edmonton, AB, Canada Abstract: Celiac disease (CD is an autoimmune reaction to gluten, leading to intestinal inflammation, villous atrophy, and malabsorption. It is the most common autoimmune gastrointestinal disorder, with an increasing prevalence. A life-long gluten-free diet (GFD is an effective treatment to alleviate symptoms, normalize autoantibodies, and heal the intestinal mucosa in patients with CD. Poorly controlled CD poses a significant concern for ongoing malabsorption, growth restriction, and the long-term concern of intestinal lymphoma. Achieving GFD compliance and long-term disease control poses a challenge, with adolescents at particular risk for high rates of noncompliance. Attention has turned toward innovative management strategies to improve adherence and achieve better disease control. One such strategy is the development of multidisciplinary clinic approach, and CD is a complex life-long disease state that would benefit from a multifaceted team approach as recognized by multiple national and international bodies, including the National Institutes of Health. Utilizing the combined efforts of the pediatric gastroenterologist, registered dietitian, registered nurse, and primary care provider (general practitioner or general pediatrician in a CD multidisciplinary clinic model will be of benefit for patients and families in optimizing diagnosis, provision of GFD teaching, and long-term adherence to a GFD. This paper discusses the benefits and proposed structure for multidisciplinary care in improving management of CD. Keywords: celiac disease

  14. The 12th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof. Dr. Matei Bals” and the 12th National Infectious Diseases Conference

    Directory of Open Access Journals (Sweden)

    Cristian-Mihail Niculae

    2016-11-01

    Full Text Available Table of contents A1 The outcome of patients with recurrent versus non-recurrent pneumococcal meningitis in a tertiary health-care hospital in Bucharest Cristian-Mihail Niculae, Eliza Manea, Raluca Jipa, Simona Merisor, Ruxandra Moroti, Serban Benea, Adriana Hristea A2 Influence of bacteriophages on sessile Gram-positive and Gram-negative bacteria Alina Cristina Neguț, Oana Săndulescu, Anca Streinu-Cercel, Dana Mărculescu, Magdalena Lorena Andrei, Veronica Ilie, Marcela Popa, Coralia Bleotu, Carmen Chifiriuc, Mircea Ioan Popa, Adrian Streinu-Cercel A3 The utility of inflammatory biomarkers in the prognostic evaluation of septic patients – past, present and future Alina Orfanu, Cristina Popescu, Anca Leuștean, Remulus Catană, Anca Negru, Alexandra Badea, Radu Orfanu, Cătălin Tilișcan, Victoria Aramă, Ştefan Sorin Aramă A4 Etiologic and clinical features of bacterial meningitis in infants Constanța-Angelica Vișan, Anca-Cristina Drăgănescu, Anuța Bilașco, Camelia Kouris, Mădălina Merișescu, Magdalena Vasile, Diana-Maria Slavu, Sabina Vintilă, Endis Osman, Alina Oprea, Sabina Sandu, Monica Luminos A5 The diagnostic and prognostic role of neutrophil to lymphocyte count ratio in sepsis Alina Orfanu, Victoria Aramă, Ştefan Sorin Aramă, Anca Leuştean, Remulus Catană, Anca Negru, Gabriel Adrian Popescu, Cristina Popescu A6 Whooping cough in a HIV positive patient Ramona Georgiana Stanculete, Ana Vaduva Enoiu, Adelina Raluca Marinescu, Voichita Lazureanu A7 Cronobacter sakazakii sepsis in varicella patient Adelina-Raluca Marinescu, Alexandru Crișan, Voichița Lăzureanu, Virgil Musta, Narcisa Nicolescu, Ruxandra Laza A8 Anaerobes an underdiagnosed cause of prosthesis joint infection Anca-Ruxandra Negru, Daniela-Ioana Munteanu, Raluca Mihăilescu, Remulus Catană, Olga Dorobăț, Alexandru Rafila, Emilia Căpraru, Marius Niculescu, Rodica Marinescu, Olivera Lupescu, Vlad Predescu, Adrian Streinu-Cercel, Victoria Aramă, Daniela

  15. Ingresos hospitalarios por enfermedades infecciosas: incidencia desde 1999 hasta 2003 en un área sanitaria de la comunidad valenciana

    Directory of Open Access Journals (Sweden)

    Antonio Guerrero Espejo

    2007-01-01

    Full Text Available Fundamento: La enfermedad infecciosa persiste en la actualidad como una de las principales causas de mortalidad y morbilidad. Su naturaleza dinámica justifica el estudio epidemiológico de las mismas. El objetivo del trabajo fue analizar la incidencia de enfermedades infecciosas que con mayor frecuencia condicionan el ingreso hospitalario. Métodos: Se realizó un estudio de las personas ingresadas entre los años 1999-2003 cuyo diagnóstico principal al alta hospitalaria se hubiera codificado, de acuerdo a la Clasificación Internacional de Enfermedades (CIE 9-MC, como enfermedad infecciosa en el Conjunto Mínimo Básico de Datos. Se seleccionaron 2.010 códigos de enfermedades infecciosas en actividad y se concentraron en 25 grupos adaptados al CIE 9- MC. La población diana fue la correspondiente a un area de la Comunidad Valenciana. Resultados: El 9,7% de los ingresos durante el periodo estudiado (8.585 registros se debió a una enfermedad infecciosa. La media de edad de las personas afectadas fue 38 años, la mediana 37, la desviación típica 31 y el rango entre 0-102 años. Predominó el ingreso de varones (54,5% sobre el de mujeres (45,5%. La tasa de incidencia de ingresos por enfermedades infecciosas fue de 728 casos/100.000 habitantes y año. La mayor tasa de ingreso se produjo en niños y ancianos. Los grupos de enfermedades con mayor número de ingresos fueron, en orden decreciente, las enfermedades infecciosas digestivas, respiratorias y genitourinarias. Conclusión: Los ingresos hospitalarios por enfermedades infecciosas alcanzaron la décima parte de los ingresos y 7 de cada 1.000 habitantes al año requirió ser hospitalizado con motivo de una patología infecciosa. Fue mayor la incidencia de las enfermedades intestinales, de aparato digestivo, respiratorio y genitourinario en la población infantil pero también, aunque en menor proporción, en los mayores de 65 años.

  16. Registered prevalence of borderline personality disorder in primary care databases Prevalencia registrada del trastorno límite de personalidad en las bases de datos de atención primaria

    Directory of Open Access Journals (Sweden)

    Enric Aragonès

    2013-04-01

    Full Text Available Objective: Borderline personality disorder (BPD is a common personality disorder, with a population prevalence of 1.4-5.9%, although the epidemiology of this disorder in primary care is insufficiently known. Our objective was to determine the registered prevalence of BPD in primary care databases and to study the demographic and clinical characteristics of these patients. Methods: We performed a cross-sectional study of the computerized databases of primary care clinical records. The target population consisted of all adults (> 16 years old registered in the Catalan Health Institute (n = 4,764,729. Results: The prevalence of recorded BPD was 0.017%, and was higher in patients with other mental disorders, particularly substance-abuse disorders (0.161%. These patients had twice as many appointments with the general practitioner as the general population (8.1 vs. 4.4. Conclusion: The number of diagnoses of BPD recorded in primary care is extremely low, which contrasts with the available population-based data.Objetivo: El trastorno límite de la personalidad (TLP es frecuente, con una prevalencia poblacional del 1,4% al 5,9%, aunque la epidemiología de este trastorno en atención primaria es escasamente conocida. Nuestro objetivo es determinar la prevalencia registrada de TLP en atención primaria y estudiar las características de estos pacientes. Métodos: Estudio transversal de las bases de datos informatizadas de las historias clínicas de atención primaria. La población diana son los adultos (>16 años registrados en el Instituto Catalán de la Salud (n = 4.764.729. Resultados: La prevalencia de TLP registrada es del 0,017%, y es mayor en los pacientes con otros trastornos mentales, particularmente trastornos por abuso de sustancias (0,161%. Estos pacientes duplican las visitas al médico general de la población general (8,1 frente a 4,4. Conclusión: Los diagnósticos de TLP registrados en atención primaria son escasos, lo que contrasta

  17. Progress in the domain of emissions tracking and environment radioactivity monitoring - Proceedings of the technical days organised by the SFRP Environment Section

    International Nuclear Information System (INIS)

    Calmet, Dominique; Calvez, Marianne; Rivasseau, Corinne Cea; Monfort, Marguerite; Manificat, Guillaume; Pierrard, Olivier; Couvez, Celine; Masson, Olivier; Bruno, Valerie; Renaud, Philippe; Genova, Zhana; Reynal, Nathalie; Le Coz, Eric; Tchilian, Nathalie; Diana, Jean-Jacques; Beguinel, Philippe; Cortes, Pierre; Puydarrieux, Stephane; Brun, Thierry; Devin, Patrick; Clavel, Benoit; Hemidy, Pierre-Yves; Gontier, Gilles; Delloye, Thierry; Mailliat, Alain; Ferreri, Giovanni; LECLERC, Elisabeth

    2015-11-01

    The Environment Section of the French Society of Radiation Protection (SFRP) organized a technical meeting on the progress made in the domain of emissions tracking and environment radioactivity monitoring. This document brings together the abstracts and the presentations (slides) of the different talks given at the meeting: 1 - Environment monitoring at the global, national and local scale: historical overview (Dominique CALMET, CEA); 2 - Evolution of radioactivity monitoring in the environment from 1960 to the present day (Guillaume MANIFICAT, IRSN); 3 - Euratom's legal framework (Zhana GENOVA, CTE); 4 - Main regulatory changes during the last decade (Nathalie REYNAL, ASN); 5 - Progress of standardization works on radioactive effluent emissions control and environment monitoring (Philippe BEGUINEL, BNEN); 6 - From operators' self-monitoring to ASN's inspections: a many components control system (Eric LE COZ, ASN); 7 - Control of effluents and emissions management at CEA Centres (Marianne CALVEZ, CEA); 8 - Liquid and gaseous effluents of ITER experimental facility: description and impacts (Pierre CORTES, IO); 9 - Effluents and emissions management strategy at AREVA NC La Hague facility (Stephane PUYDARRIEUX, AREVA); 10 - Radioactive effluents from nuclear facilities ongoing deconstruction: from dimensioning to real effluents (Benoit CLAVEL, EDF); 11 - Radionuclides decontamination process for liquid effluents using micro-algae at the laboratory scale (Corinne RIVASSEAU, CEA); 12 - Radioactive effluents from nuclear medicine services: management, monitoring and impact measurement methods (Nathalie TCHILIAN, ASN); 13 - Evolution history of effluents management and environment monitoring at the Solvay La Rochelle site (Thierry DELLOYE, SOLVAY); 14 - Different international approaches in effluents management and monitoring: example of French and German gaseous effluents - regulation, analyses, accounting rules (Jean-Jacques DIANA, ASN); 15 - Environment

  18. Antidepressant exposure in pregnancy and risk of autism spectrum disorders

    Directory of Open Access Journals (Sweden)

    Sørensen MJ

    2013-11-01

    Full Text Available Merete Juul Sørensen,1 Therese Koops Grønborg,2 Jakob Christensen,3,4 Erik Thorlund Parner,2 Mogens Vestergaard,5,6 Diana Schendel,7 Lars Henning Pedersen8,9 1Regional Centre of Child and Adolescent Psychiatry, Aarhus University Hospital, Risskov, Denmark; 2Department of Public Health, Section of Biostatistics, Aarhus University, Aarhus, Denmark; 3Department of Neurology, Aarhus University Hospital, Aarhus, Denmark; 4Department of Clinical Pharmacology, 5Department of Public Health, Section of General Practice, 6Research unit for General Practice, Aarhus University, Aarhus, Denmark; 7Centers for Disease Control and Prevention, Atlanta, GA, USA; 8Danish Epidemiological Science Centre, Institute of Public Health, 9Department of Obstetrics and Gynecology, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark Background: Both the use of antidepressant medication during pregnancy and the prevalence of autism spectrum disorder have increased during recent years. A causal link has recently been suggested, but the association may be confounded by the underlying indication for antidepressant use. We investigated the association between maternal use of antidepressant medication in pregnancy and autism, controlling for potential confounding factors. Methods: We identified all children born alive in Denmark 1996–2006 (n=668,468 and their parents in the Danish Civil Registration System. We obtained information on the mother's prescriptions filled during pregnancy from the Danish National Prescription Registry, and on diagnoses of autism spectrum disorders in the children and diagnoses of psychiatric disorders in the parents from the Danish Psychiatric Central Register. In a cohort analysis, we estimated hazard ratios of autism spectrum disorders in children exposed to antidepressant medication during pregnancy compared with children who were not exposed, using Cox proportional hazards regression analysis. Furthermore, we estimated the risk

  19. Seafloor distribution and last glacial to postglacial activity of mud volcanoes on the Calabrian accretionary prism, Ionian Sea

    Science.gov (United States)

    Ceramicola, Silvia; Praeg, Daniel; Cova, Andrea; Accettella, Daniela; Zecchin, Massimo

    2014-06-01

    Mud volcanoes (MVs) are abundant along the eastern Mediterranean subduction zones, recording mud breccia extrusion over long timescales (106 years), but to date relatively few have been recognised in the northern Ionian Sea on the Calabrian accretionary prism (CAP). In the present study, the seafloor distribution and recent activity of MVs is investigated across a 35,600 km2 sector of the CAP using a regional acoustic dataset (multibeam bathymetric and backscatter imagery, integrated with subbottom profiles) locally ground-truthed by sediment cores. A total of 54 MVs are identified across water depths of 150-2,750 m using up to four geophysical criteria: distinctive morphology, high backscatter, unstratified subbottom facies and, in one case, a hydroacoustic flare. Fourteen MVs are identified from 3-4 criteria, of which five have been previously proven by cores containing mud breccia beneath up to 1.6 m of hemipelagic sediments (Madonna dello Ionio MVs 1-3, Pythagoras MV and the newly named Sartori MV), while nine others are identified for the first time (Athena, Catanzaro, Cerere, Diana, Giunone, Minerva, `right foot', Venere 1 and 2). Forty other as yet unnamed MVs are inferred from 1-2 geophysical criteria (three from distinctive morphology alone). All but one possible MV lie on the inner plateau of the CAP, landwards of the Calabrian Escarpment in a zone up to 120 km wide that includes the inner pre-Messinian wedge and the fore-arc basins, where they are interpreted to record the ascent from depth of overpressured fluids that interacted with tectonic structures and with evaporitic or shale seals within the fore-arc basins. The rise of fluids may have been triggered by post-Messinian out-of-sequence tectonism that affected the entire pre-Messinian prism, but Plio-Quaternary sedimentation rates and depositional styles support the inference that significant mud volcanism has taken place only on the inner plateau. Sedimentation rates across the CAP applied to a 12

  20. Instrument for assessing mobile technology acceptability in diabetes self-management: a validation and reliability study

    Directory of Open Access Journals (Sweden)

    Frandes M

    2017-02-01

    Full Text Available Mirela Frandes,1 Anca V Deiac,2 Bogdan Timar,1,3 Diana Lungeanu1,2 1Department of Functional Sciences, “Victor Babes” University of Medicine and Pharmacy of Timisoara, 2Department of Mathematics, Polytechnic University of Timisoara, 3Third Medical Clinic, Emergency Hospital of Timisoara, Timisoara, Romania Background: Nowadays, mobile technologies are part of everyday life, but the lack of instruments to assess their acceptability for the management of chronic diseases makes their actual adoption for this purpose slow.Objective: The objective of this study was to develop a survey instrument for assessing patients’ attitude toward and intention to use mobile technology for diabetes mellitus (DM self-management, as well as to identify sociodemographic characteristics and quality of life factors that affect them.Methods: We first conducted the documentation and instrument design phases, which were subsequently followed by the pilot study and instrument validation. Afterward, the instrument was administered 103 patients (median age: 37 years; range: 18–65 years diagnosed with type 1 or type 2 DM, who accepted to participate in the study. The reliability and construct validity were assessed by computing Cronbach’s alpha and using factor analysis, respectively.Results: The instrument included statements about the actual use of electronic devices for DM management, interaction between patient and physician, attitude toward using mobile technology, and quality of life evaluation. Cronbach’s alpha was 0.9 for attitude toward using mobile technology and 0.97 for attitude toward using mobile device applications for DM self-management. Younger patients (Spearman’s ρ=-0.429; P<0.001 with better glycemic control (Spearman’s ρ=-0.322; P<0.001 and higher education level (Kendall’s τ=0.51; P<0.001 had significantly more favorable attitude toward using mobile assistive applications for DM control. Moreover, patients with a higher quality of

  1. Endoscopic evaluation and histological findings in graft-versus-host disease Evaluación endoscópica y hallazgos histológicos en la enfermedad de injerto contra huésped

    Directory of Open Access Journals (Sweden)

    Antonio Velasco-Guardado

    2012-06-01

    Full Text Available Background: the gastrointestinal (GI tract is the major target site of the graft-versus-host disease (GVHD. Diagnosis is based on endoscopic and histological findings. Material and methods: we performed a retrospective study from January 1st, 1990 to December 31st, 2008 on 338 upper gastrointestinal endoscopies (gastroscopies performed to 197 patients that underwent an allogeneic transplant with clinical suspicion of GI-GVHD. Results: endoscopic findings to the diagnosis of GVHD have a sensitivity (S of 34%, specificity levels (SP of 65%, a positive predictive value (PPV of 73% and a negative predictive value (NPV of 48%. The histological study of the endoscopic biopsies has a global sensibility of 85.6% SP = 34.6% PPV = 64.2% and NPV = 63.7%. Histological grade was correlated with the clinical grade of acute GVHD (p = 0.018. Conclusion: upper gastrointestinal endoscopy is useful for the diagnosis of GVHD, as it allows biopsies that can ultimately lead to the diagnosis, but with limited accuracy because the histological findings have low sensitivity and specificity, while the endoscopic findings are generally nonspecific.Introducción: el tracto gastrointestinal es la diana principal de afectación en la enfermedad de injerto contra huésped (EICH. Su diagnóstico se basa en los hallazgos endoscópicos e histológicos. Material y métodos: hemos realizado un estudio retrospectivo, desde el 1 de enero de 1990 hasta el 30 de diciembre de 2008, de 338 endoscopias digestivas altas realizadas a 197 pacientes sometidos a trasplante alogénico de células hematopoyéticas con sospecha de EICH gastrointestinal. Resultados: los hallazgos endoscópicos tienen una sensibilidad (S del 34%, especificidad (E del 65%, valor predictivo positivo (VPP del 73% y valor predictivo negativo (VPN del 48% para el diagnóstico de EICH. El estudio histológico de las biopsias tiene una S del 85,6%, E del 34,6%, VPP del 64,2% y VPN del 63,7%. El grado histológico se

  2. Energy-efficiency labels and standards: A guidebook for appliances, equipment and lighting

    Energy Technology Data Exchange (ETDEWEB)

    McMahon, James E.; Wiel, Stephen

    2001-02-16

    Energy-performance improvements in consumer products are an essential element in any government's portfolio of energy-efficiency and climate change mitigation programs. Governments need to develop balanced programs, both voluntary and regulatory, that remove cost-ineffective, energy-wasting products from the marketplace and stimulate the development of cost-effective, energy-efficient technology. Energy-efficiency labels and standards for appliances, equipment, and lighting products deserve to be among the first policy tools considered by a country's energy policy makers. The U.S. Agency for International Development (USAID) and the United Nations Foundation (UNF) recognize the need to support policy makers in their efforts to implement energy-efficiency standards and labeling programs and have developed this guidebook, together with the Collaborative Labeling and Appliance Standards Program (CLASP), as a primary reference. This guidebook was prepared over the course of the past year with significant contribution from the authors and reviewers mentioned previously. Their diligent participation has made this the international guidance tool it was intended to be. The lead authors would also like to thank the following individuals for their support in the development, production, and distribution of the guidebook: Marcy Beck, Elisa Derby, Diana Dhunke, Ted Gartner, and Julie Osborn of Lawrence Berkeley National Laboratory as well as Anthony Ma of Bevilacqua-Knight, Inc. This guidebook is designed as a manual for government officials and others around the world responsible for developing, implementing, enforcing, monitoring, and maintaining labeling and standards-setting programs. It discusses the pros and cons of adopting energy-efficiency labels and standards and describes the data, facilities, and institutional and human resources needed for these programs. It provides guidance on the design, development, implementation, maintenance, and evaluation of the

  3. Envejecimiento y Hospitalización Domiciliaria Ageing and Hospital Home Care

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    Rosângela Minardi Mitre Cotta

    2004-03-01

    Full Text Available Objetivo: Analizar las características de la población diana de hospitalización domiciliaria (HD, su estructura y competencia. Método: Estudio descriptivo retrospectivo. Resultados: El 78,8% de los pacientes son mayores de 65 años. Los procesos crónicos representan el 46,9%. Para los grupos de causas patológicas, el 52,1% se incluyen en la categoría de otras pluripatologías, seguido de los tumores y neoplasias (28% y las enfermedades del aparato circulatorio (18,8%. La principal puerta de entrada en HD fue la UMCE (53,0% y el principal destino de los pacientes fue la atención primaria (62,0%. Discusión: Los ancianos con plurupatologias crónicas o terminales tienen en la HD una estrategia eficiente, ya que son pacientes que por su complejidad pueden superar las posibilidades de tratamiento en atención primaria. Se concluye que hay un problema de comunicación entre la atención primaria y el hospital, que obviamente se proyecta hacia los pacientes y hacia la calidad y efectividad de la asistencia sanitaria.Objective: This study aimed to analyze the characteristics of a Hospital Home Care target population, its structure and competence. Methods: Retrospective descriptive study. Results: The results of this study indicated that 78,8% of the patients were more than 65 years old Chronic process represented 46,9% of the cases. Among the pathology causes group, 52,1% were included in the pluripathologies category, followed by tumors and neoplasies (28% and by circulatory diseases (18,8%. The main admission way to Hospital Home Care was by the Short Staying Medical Unity (53% and the main destination of the patients was to the primary attention (62%. Discussion: Aged people with chronic or terminal pluripathologies met an efficient strategy in Hospital Home Care, considering that due to their own complexities, they can surpass treatment possibilities in primary attention. In conclusion, there is hospital, which clearly is projected to

  4. Entérate de cómo cambia el cerebro cuando se lesiona un nervio

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    Julieta Troncoso

    2016-02-01

    Full Text Available Desde hace algunos años el grupo de investigación de Neurofisiología Comportamental de la Universidad Nacional de Colombia ha venido evaluando los cambios que ocurren en el sistema nervioso central luego de la lesión de un nervio periférico. Específicamente trabajamos con el modelo de lesión del nervio facial en roedores para evaluar las modificaciones funcionales y estructurales que ocurren en la corteza sensoriomotora primaria luego de la lesión. Al lesionarse el nervio facial, el cerebro entra en un programa de reorganización que incluye cambios electrofisiológicos en las neuronas de la corteza motora que comandan los movimientos faciales (M1. En este sentido, las células de la corteza motora cerebral se vuelven más excitables y modifican su respuesta ante estímulos sensoriales. La reorganización tras la lesión también incluye cambios morfológicos en M1: las células piramidales de la corteza motora retraen su árbol dendrítico y disminuye la densidad de sus espinas dendríticas. En asociación con estos cambios, las células de M1 disminuyen transitoriamente su inmunorreactividad para NeuN (marcador específico de núcleos neuronales y aumentan la expresión de GAP43 (proteína de crecimiento axonal. Esto indica, posiblemente, un cambio metabólico celular en asociación con la búsqueda de nuevas dianas sinápticas. Finalmente, hallamos que la glía circundante en M1 (tanto astrocitos como microglía se activa de manera muy temprana luego de lesiones del nervio facial. Esto podría indicar que el remodelamiento estructural y funcional hallado en las neuronas corticales es el resultado de la interacción entre la activación de la glía circundante y las células piramidales de M1 (aunque se necesitan muchos experimentos adicionales que así lo demuestren.

  5. Reviews of recent publications

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    1997-06-01

    Modernism by Constantin V. Ponomareff Spanish Studies Cardenal, Ernesto. The Doubtful Strait . Trans. John Lyons by Juan Carlos Galeano Garcia Marquez, Gabriel. Of Love and Other Demons by John Cussen Lindstrom, Naomi. Twentieth-Century Spanish American Fiction by Norma Helsper Meyer, Doris, Ed. Reinterpreting the Spanish American Essay: Women Writers of the 19th and 20th Centuries by Judy Maloof and Fernando Unzueta Nantell, Judith. The Poetry of Francisco Brines: The Deconstructive Effects of Languages by Anita M. Hart Taylor, Diana and Juan Villegas, Eds. Negotiating Performance: Gender, Sexuality, & Theatricality in Latin America by Anne M. Pasero

  6. Conocimientos de la población sobre lepra Knowledge of the population about leprosy

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    Isora Montenegro Valera

    2006-12-01

    Full Text Available Se realizó un estudio observacional descriptivo de tipo transversal para investigar el nivel de conocimientos, que sobre la lepra, tiene la población en el municipio de Limonar, durante el período de Marzo a Diciembre de 2002. Participaron en el estudio 395 pacientes mayores de 15 años, que fueron seleccionados de la población del municipio mediante un diseño multietápico que incluyó la estratificación y el conglomerado. Los datos fueron procesados en el sistema estadístico SPSS-10. Se utilizaron técnicas estadísticas como el Chi cuadrado para explorar la asociación significativa entre variables. Se obtuvo como resultado que existe desconocimiento por parte de la población acerca de la enfermedad, ya que solamente el 17,97 % de la población mostró conocimientos adecuados, y se encontró relación significativa entre este, el sexo femenino y la escolaridad. Sobre la base de los resultados se recomiendan las audiencias diana para una efectiva intervención educativa en la Atención Primaria de Salud en este municipio.An observational, descriptive and cross-sectional study was undertaken to investigate the level of knowledge of the population about leprosy in Limonar municipality from March to December, 2002. 395 patients over 15 participated in the study. They were selected from the population of the municipality by a multistage design that included stratification and cluster. The data were processed by the SPSS-10 statistical system. Statistical techniques as the Chi square test were used to explore the significant association among the variables. It was concluded that there is lack of knowledge about the disease, since only 17.97 % of the population showed an adequate knowledge. A significant relation was found among knowledge, the female sex and the educational level. According to these results, the target hearings are recommended for an effective educative intervention at the primary health care level in this municipality.

  7. Comportamiento de las crisis hipertensivas en el Área Intensiva Municipal de Centro Habana

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    Edrinson Alfredo Naranjo Casañas

    Full Text Available Introducción: la Hipertensión Arterial continúa siendo una de las enfermedades crónicas más comunes en nuestro país y el mundo, llegando a tener un rol protagónico como factor de riesgo importante para el padecimiento o agravamiento de otras enfermedades letales. Objetivo: caracterizar el comportamiento de las crisis hipertensivas en los pacientes ingresados en el Área Intensiva del Policlínico Docente "Dr. Joaquín Albarrán". Métodos: se realizó una investigación descriptiva, de corte transversal, en el período comprendido entre diciembre de 2010 a diciembre de 2012. El universo estuvo constituido por los 767 pacientes de 15 y más años de edad, de ambos sexos, que acudieron al Servicio de Urgencia del policlínico y requirieron ingreso en la Unidad de Cuidados Intensivos. Los resultados se mostraron en tablas estadísticas de frecuencias absolutas y relativas. Resultados: predominó el ingreso en los grupos de edades de 40-49 años (23,8 %, seguido del grupo de 60 y más (22,1 %. La principal modalidad de crisis se correspondió con las Urgencias Hipertensivas, 442 (57,6 %. El medicamento de mayor uso como tratamiento de la crisis fue el Captopril en tableta con un total de 562 (93,2 %. El principal órgano diana afectado fue el corazón. Conclusiones: el mayor número de ingresos se produjo en los pacientes de 40-49 años de edad con mayoría del sexo masculino; la modalidad de crisis hipertensiva que más se presentó fue las Urgencias Hipertensivas, y el medicamento de mayor uso como tratamiento fue el Captopril en tableta.

  8. Prevalencia de actividad física y su relación con variables sociodemográficas y estilos de vida en la población de 18 a 65 años de Pamplona

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    José Javier Elizondo-Armendáriz

    2005-01-01

    Full Text Available Fundamento: Los conocimientos actuales permiten considerar que existe una asociación de tipo causal entre el nivel de actividad física y la aparición de diversas enfermedades. A pesar de ello, la actividad física es una práctica poco arraigada en la población, que cada vez se está haciendo más sedentaria. El objetivo de este estudio es describir la prevalencia de sedentarismo en la población de Pamplona, así como conocer cuáles son los factores que más influyen en él. Métodos: Se llevó a cabo un estudio transversal mediante encuesta postal en una muestra significativa de la población de Pamplona de 18 a 65 años. La encuesta utilizada incluía una evaluación de la actividad física realizada, basada en el cuestionario de actividad física de Paffenbarger. Se realizó un análisis bivariado y multivariado con aplicación de regresión logística. Resultados: Un 76,6% de las mujeres tienen un estilo de vida sedentario, mientras que en los varones este porcentaje se reduce hasta un 56,7%. El sedentarismo se incrementa con la edad, existiendo hasta un 80,3% de varones sedentarios en el grupo de mayor edad, y un 86,3% entre las mujeres, respectivamente. Conclusiones: Los factores sociodemográficos como sexo, edad, estudios, profesión y estado civil parecen ser determinantes del estilo de vida sedentario, mientras el consumo de tabaco y la existencia de sobrepeso y obesidad no lo son. Entre las personas jóvenes, las mujeres sin estudios universitarios y los varones casados y fumadores parecen ser poblaciones diana para la promoción de la actividad física.

  9. ATENCION PRIMARIA Y RESPONSABILIDADES DE SALUD PÚBLICA EN SEIS PAÍSES DE EUROPA Y AMÉRICA DEL NORTE: UN ESTUDIO PILOTO

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    Barbara Starfield

    2004-01-01

    Full Text Available Fundamento: Los rápidos cambios en los sistemas sanitarios son una oportunidad para reorientar las relaciones entre sus diferentes componentes. Con el objetivo de conocer dónde se ubica la responsabilidad para la realización de diferentes tipos de actividades preventivas, se realizó una encuesta en ocho áreas geográficas de seis países de Europa y Norteamérica. Métodos: Encuesta entre expertos basada en una matriz que relaciona servicios sanitarios preventivos con la población a la que se dirigen. Se establecieron ocho situaciones clínicas (vacunaciones infantiles y antigripal adultos; y detección precoz: de cáncer mediante mamografía, de tuberculosis, de Hipertensión Arterial, de fenilcetonuria, del virus de la inmunodeficiencia humana, y de osteoporosis, con el fin de conocer en relación a las mismas la población diana, nivel de establecimiento de las políticas, nivel de contacto con los individuos, seguimiento de los individuos con diagnósticos positivos y registro de sus datos clínicos. Resultados: Este estudio piloto mostró muy escasa coincidencia de los resultados tanto entre las ocho áreas encuestadas como en cada una de ellas. No se encontró un patrón regular para las actividades de prevención exploradas entre los diferentes países, ni en función de la tipología de sus sistemas sanitarios, ni por la orientación hacia la atención primaria de los diferentes sistemas. Conclusiones: Existe un escaso consenso en las áreas estudiadas en relación con la mejor forma de realizar las intervenciones de salud pública que conllevan prestación de atención sanitaria personal.

  10. Guía de actuación para el farmacéutico comunitario en pacientes con hipertensión arterial y riesgo cardiovascular: Documento de consenso

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    Sabater Hernández D

    2011-06-01

    Full Text Available La hipertensión arterial (HTA es un problema de salud estrechamente relacionado con un aumento del riesgo de padecer una enfermedad cardiovascular. Además, la HTA puede producir o empeorar la lesión de ciertos órganos diana, lo que también puede influir negativamente en el pronóstico cardiovascular del paciente. En España, la HTA es una condición muy frecuente, afectando a unos diez millones de sujetos adultos. Por su accesibilidad y formación especializada en materia de medicamentos, el farmacéutico comunitario puede jugar un papel clave en la detección y seguimiento del paciente con HTA. Hasta la fecha, se han publicado numerosas guías clínicas sobre la atención a pacientes con HTA, dirigidas principalmente a médicos. Sin embargo, cada vez es más evidente la necesidad de que todos los profesionales de la salud participen en la atención integral a los pacientes con HTA y riesgo cardiovascular (RCV. La cooperación entre farmacéutico, médico, personal de enfermería y otros profesionales sanitarios es imprescindible para conseguir resultados que optimicen la prevención cardiovascular y mejoren la calidad de vida del paciente. Así, a fin de promover la gestión compartida de los pacientes con HTA y RCV se publica este documento, cuyo principal destinatario es el farmacéutico comunitario. El presente documento pretende ser una herramienta de referencia que dé soporte a los programas de atención farmacéutica al paciente con HTA y RCV que se están desarrollando actualmente en las oficinas de farmacia. El texto ha sido desarrollado de forma consensuada entre expertos de la Sociedad Española de Hipertensión-Liga Española para la Lucha contra la Hipertensión Arterial (SEH-LELHA, la Sociedad Española de Farmacia Comunitaria (SEFAC y el Grupo de Investigación en Atención Farmacéutica de la Universidad de Granada (GIAF-UGR.

  11. Evaluación de riesgo biológico en el Hospital Rey Don Jaime

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    Salomé Benavent Nácher

    2007-03-01

    Full Text Available Objetivo: El propósito del presente trabajo es realizar una evaluación del riesgo biológico existente para los trabajadores del Hospital con el fin de identificar los puestos de trabajo y microorganismos que suponen mayor riesgo y poder adoptar medidas preventivas. Métodos: Se aplicó la metodología BIOGAVAL de evaluación de riesgo biológico desarrollado por el Gabinete de Seguridad e Higiene de Valencia. Dicho método contempla una identificación de los microorganismos presentes mas probables, su posible daño a la salud, mecanismos de transmisión, porcentaje de población diana vacunado y el efecto protector de las medidas higiénicas. Se aplicó a los distintos puestos de trabajo que presentan riesgo biológico exceptuando cocina. Resultados: Los resultados evidencian un mayor riesgo para los microorganismos de transmisión aérea y con baja protección vacunal, así como un nivel de riesgo superior (comparado con otros trabajadores de los ATS/DUE de urgencias. Conclusiones: El método se ha revelado útil para evidenciar los puestos de trabajo más peligrosos así como los agentes microbiológicos de mayor riesgo. Igualmente aporta una orientación sobre la prioridad para la aplicación de medidas preventivas de control.Objective: The purpose of this work is to realize an evaluation of the existing biological risk for the staff at the hospital with the aim of both identifying the jobs and microorganisms which mean a higher risk and to be able to adopt preventive measures. Methods: It was applied the BIOGAVAL methodology of evaluation of biological risk developed by the Safety and Hygiene Office in Valencia. This method deals with an identification of the most probable present microorganisms, their possible hurt for health, transmission mechanisms, percentage of target population vaccinated and the protective effect of the hygienic measures. It was applied to the different jobs which show biological risk except for the kitchen ones

  12. Regenerative medicine in the treatment of idiopathic pulmonary fibrosis: current position

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    Álvarez D

    2015-04-01

    Full Text Available Diana Álvarez,1,2 Melanie Levine,1 Mauricio Rojas1–3 1Dorothy P and Richard P Simmons Center for Interstitial Lung Disease, 2Pulmonary, Allergy, and Critical Care Medicine, 3McGowan Institute for Regenerative Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA Abstract: Idiopathic pulmonary fibrosis (IPF is a progressive, irreversible disease of the lung that has no lasting option for therapy other than transplantation. It is characterized by replacement of the normal lung tissue by fibrotic scarring, honeycombing, and increased levels of myofibroblasts. The underlying causes of IPF are still largely unknown. The focus of the current review is the possible use of stem cell therapy, specifically mesenchymal stem cells (MSCs, a multipotent stromal cell population, which have demonstrated promising data in multiple animal models of pulmonary fibrosis (PF. The most studied source of MSCs is the bone marrow, although they can be found also in the adipose tissue and umbilical cord, as well as in the placenta. MSCs have immunomodulatory and tissue-protective properties that allow them to manipulate the local environment of the injured tissue, ameliorating the inflammation and promoting repair. Because IPF primarily affects older patients, the issue of aging is intrinsically linked to many aspects of the disease, including the age of the stem cells. Animal models have shown the success of MSC therapy in mitigating the fibrotic effects of bleomycin-induced PF. However, bleomycin, the most commonly used model for PF, is imperfect in mimicking IPF as it presents in humans, as the duration of the illness is not parallel or reversible, and honeycombing is not produced. Furthermore, the time of MSC dosage has proven to be critical in determining whether the cells will ultimately have a positive or negative effect on disease progression, since it has been demonstrated that the maximal beneficial effect of MSCs occurs during the early

  13. PREVALENCIA DEL DÉFICIT DE ATENCIÓN E HIPERACTIVIDAD EN PERSONAS ADULTAS SEGÚN EL REGISTRO DE LAS HISTORIAS CLÍNICAS INFORMATIZADAS DE ATENCIÓN PRIMARIA

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    Enric Aragonès

    2010-01-01

    Full Text Available Fundamento:El TDAH en adultos no es infrecuente y, según datos epidemiológicos recientes, tiene una prevalencia poblacional del 3-4%. Sin embargo, existe un gran desconocimiento sobre este trastorno entre los médicos, particularmente en atención primaria. El objetivo de este trabajo es determinar la prevalencia del diagnóstico registrado de TDAH en adultos y la proporción de pacientes con prescripción farmacológica para este trastorno en atención primaria. Métodos:Se trata de un estudio transversal sobre las bases de datos de las historias clínicas electrónicas de atención primaria. La población diana son los adultos (18-44 años adscritos a centros de salud del Instituto Catalán de la Salud (n=2.452.107. Hemos obtenido la proporción de pacientes con diagnóstico de TDAH (código F90/CIE-10 en la lista de problemas activos, y la proporción de pacientes con prescripción activa de un fármaco específico para el TDAH en adultos: metilfenidato, metilfenidato de liberación prolongada o atomoxetina. Resultados:La prevalencia de TDAH registrado es del 0,04% (0,07% en hombres; 0,02% en mujeres. Los pacientes con prescripción para TDAH son el 0,07% (0,08% en hombres; 0,05% en mujeres. El 32,05% de los TDAH tenían prescripción específica. Conclusión:El diagnóstico en adultos de TDAH y el tratamiento específico son extremadamente bajos en atención primaria. Estos resultados contrastan con los datos poblacionales: el TDAH registrado es 1/85 de la prevalencia poblacional.

  14. ÍNDICE

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    MARÍA JESUS MARRON GAITE

    2015-12-01

    Full Text Available PRESENTACIÓN: La investigación en Educación GeográficaCOORDINACIÓN: Ramón Martínez Medina.................................................... 7ARTÍCULOSFormer ses élèves à L’abstraction en géographieBernadette Mérenne-Schoumaker................................................................ 25El paisaje en la Educación Secundaria Obligatoria. Una oportunidad educativa en el cambio curricular LOE-LOMCEMaría Casas Jericó y Luis Erneta Altarriba ...................................................... 4Parques naturales: la necesaria conceptualización transformadora en la Educación Primaria y SecundariaDiana Santana Martín, Antonio José Morales Hernández, Juan Carlos Colomer Rubio, Benito Campo Pais, Carlos Caurín Alonso............................................ 73Le territoire, un concept sensible : enjeux didactiques et politiques dans le contexte scolaire françaisEric Ratzel et Jean-François Thémines..................................................................................................95La obra La recogida de la manzana como pretexto para la lectura e interpretación del paisaje tradicional a través de una fuente iconográfica: un estudio con alumnado de 2º de BachilleratoRoberto García-Morís..................................................................................................... 115Propuesta didáctica para la interpretación del espacio geográfico: la ciudad de Segovia y su entornoLuis Carlos Martínez Fernández, Berta Fernández-Vega Peláez e Ignacio Molina de la Torre.................................................................................................. 135Aportes del enfoque de género para una enseñanza inclusiva de la Geografía escolarMaría Victoria Fernández Caso y Daniela Guberman....................................... 165El modelo TPACK en los estudios de Grado para la formación inicial del profesorado en TIC Isabel Mª Gómez Trigueros

  15. DESARROLLO DE UN MARCO CONCEPTUAL PARA LA EVALUACIÓN DE LA ATENCIÓN A LA CRONICIDAD EN EL SISTEMA NACIONAL DE SALUD

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    Mireia Espallargues

    2016-01-01

    Full Text Available El objetivo del trabajo fue desarrollar un marco conceptual para la evaluación de nuevos programas de gestión clínica y asistencial de carácter integrado en el Sistema Nacional de Salud para la atención a las personas con enfermedades crónicas. Se realizó una revisión exhaustiva de la literatura entre 2002-2013 incluyendo revisiones sistemáticas, metaanálisis e informes con modelos de evaluación y/o evaluaciones de programas. Se estudiaron y describieron programas locales de atención a la cronicidad implementados en Cataluña y se realizaron entrevistas semiestructuradas con expertos clave en el ámbito catalán. El alcance y el marco conceptual se definieron mediante la técnica del brainstorming. De 910 resúmenes identificados, se incluyeron 116 documentos que se referían a marcos conceptuales e indicadores de evaluación a nivel español e internacional. Se identificaron 24 programas de atención a la cronicidad (9 de carácter integrado. El marco conceptual propuesto contempló: 1 la población diana según niveles de complejidad; 2 un enfoque de evaluación de la estructura, procesos y resultados teniendo en cuenta el estado de salud conseguido, el proceso de recuperación y mantenimiento de la salud; y 3 las dimensiones o atributos que se deben evaluar. El marco conceptual propuesto permitirá desarrollar indicadores e implementarlos con un enfoque comunitario, orientados a los resultados y tener una visión territorial o poblacional, que será imprescindible para saber cuál es la estrategia más efectiva, cuáles son los elementos que determinan un mayor éxito y cuáles son los grupos de pacientes que más se pueden beneficiar.

  16. Perturbed microRNA Expression by Mycobacterium tuberculosis Promotes Macrophage Polarization Leading to Pro-survival Foam Cell.

    Science.gov (United States)

    Ahluwalia, Pankaj Kumar; Pandey, Rajan Kumar; Sehajpal, Prabodh Kumar; Prajapati, Vijay Kumar

    2017-01-01

    Tuberculosis (TB) is one of the prevalent causes of death worldwide, with 95% of these deaths occurring in developing countries, like India. The causative agent, Mycobacterium tuberculosis (MTb) has the tenacious ability to circumvent the host's immune system for its own advantage. Macrophages are one of the phagocytic cells that are central to immunity against MTb. These are highly plastic cells dependent on the milieu and can showcase M1/M2 polarization. M1 macrophages are bactericidal in action, but M2 macrophages are anti-inflammatory in their immune response. This computational study is an effort to elucidate the role of miRNAs that influences the survival of MTb in the macrophage. To identify the miRNAs against critical transcription factors, we selected only conserved hits from TargetScan database. Further, validation of these miRNAs was achieved using four databases viz . DIANA-microT, miRDB, miRanda-mirSVR, and miRNAMap. All miRNAs were identified through a conserved seed sequence against the 3'-UTR of transcription factors. This bioinformatics study found that miR-27a and miR-27b has a putative binding site at 3'-UTR of IRF4, and miR-302c against IRF5. miR-155, miR-132, and miR-455-5p are predicted microRNAs against suppressor of cytokine signaling transcription factors. Several other microRNAs, which have an affinity for critical transcription factors, are also predicted in this study. This MTb-associated modulation of microRNAs to modify the expression of the target gene(s) plays a critical role in TB pathogenesis. Other than M1/M2 plasticity, MTb has the ability to convert macrophage into foam cells that are rich in lipids and cholesterol. We have highlighted few microRNAs which overlap between M2/foam cell continuums. miR-155, miR-33, miR-27a, and miR-27b plays a dual role in deciding macrophage polarity and its conversion to foam cells. This study shows a glimpse of microRNAs which can be modulated by MTb not only to prevent its elimination but also

  17. Empleo de la técnica hibridación in situ fluorescente para visualizar microorganismos Use of fluorescence in situ hybridization technique to visualize microorganisms

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    Raúl Rodríguez Martínez

    2011-12-01

    Full Text Available La hibridación in situ fluorescente (FISH, es una técnica que emplea sondas de oligonucleótidos marcadas con fluorocromos las cuales van dirigidas hacia secuencias específicas del ácido ribonucleico ribosomal (ARNr, lo que permite la identificación rápida y específica de células microbianas ya sea que estén como células individuales o se encuentren agrupadas en su ambiente natural. El conocimiento de la composición y distribución de los microorganismos en los hábitats naturales, proporciona un soporte sólido para comprender la interacción entre las diversas especies que componen el micro hábitat. El objetivo de la revisión es presentar la forma como ha evolucionado la hibridación, el empleo del ARNr como molécula diana, los tipos de marcaje, los marcadores fluorescentes empleados hoy en día, la metodología, así como las mejoras que se le han hecho a la técnica FISH al emplearse en conjunto con otras técnicas en la identificación microbiana. Salud UIS 2011; 43 (3: 307-316Fluorescence in situ hybridization (FISH, is a technique that uses oligonucleotides probes labeled with fluorochromes which are directed to specific sequences of ribosomal ribonucleic acid (rRNA, this allows the rapid and specific identification of microbial cells whether as individual cells or grouped cells in their natural environment. Knowledge of the composition and distribution of microorganisms in natural habitats provides a solid support to understand interaction between different species in the microhabitat. This review shows how hybridization has evolved, the use of rRNA as target molecule, the type of labeling, the labeled uses today in fluorescent and the methodology, as well as the improvements that have been made to the FISH technique when is used in conjunction with other techniques in microbial identification. Salud UIS 2011; 43 (3: 307-316

  18. Estimación de la exposición al humo ambiental de tabaco: revisión de cuestionarios utilizados en España Estimation of environmental tobacco smoke exposure: review of questionnaires used in Spain

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    Manel Nebot

    2011-08-01

    Full Text Available Introducción: En los últimos años, las encuestas de salud y los estudios epidemiológicos sobre el tabaquismo han incorporado preguntas sobre la exposición al humo ambiental de tabaco, aunque no existe un cuestionario estandarizado. Métodos: Entre enero y mayo de 2008 se revisaron las encuestas que contenían preguntas sobre exposición a tabaquismo pasivo realizadas en España desde las administraciones públicas, las sociedades científicas y organismos de investigación. Se han revisado los literales, que se han clasificado según tipo de estudio, población diana, ámbito geográfico y lugar de exposición. Resultados: Se identificaron 27 encuestas que incluían tabaquismo pasivo. La mayoría correspondían a encuestas de salud (81,5% e iban dirigidas a población general (70,4%. El ámbito geográfico más común era el autonómico (48,1% y el lugar de exposición más común el hogar (88,9%. Discusión: Los resultados muestran una enorme variabilidad en las preguntas utilizadas. Es necesario homogeneizar las preguntas sobre exposición al tabaquismo pasivo si queremos comparar los resultados.Introduccion: In the last few years, health surveys and epidemiological studies on smoking have introduced questions on environmental tobacco smoke (ETS exposure. However, a standardized questionnaire is lacking. Methods: Between January and May 2008, we reviewed surveys containing items on ETS exposure carried out in Spain by public administrations, scientific societies and research institutes. The wording of the questions was reviewed and classified according to the study type, target population, geographical setting and place of exposure. Results: We identified 27 surveys that included questions on passive smoking. Most were health surveys (81.5% and were aimed at the general population (70.4%. The most frequent geographical setting consisted of autonomous regions (48.1% and the most common place of exposure was the home (88.9% Discussion: The

  19. Diagnosis reliability of combined flexible sigmoidoscopy and fecal-immunochemical test in colorectal neoplasia screening

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    Iovanescu D

    2016-11-01

    Full Text Available Dana Iovanescu,1 Mirela Frandes,2 Diana Lungeanu,2 Amelia Burlea,3 Bogdan P Miutescu,4 Eftimie Miutescu1 1Department of Gastroenterology, Faculty of Medicine, Pharmacy and Dental Medicine, “Vasile Goldis” West University of Arad, 2Department of Functional Sciences, “Victor Babes” University of Medicine and Pharmacy of Timisoara, 3Department of Pathology, County Hospital of Arad, 4Department of Gastroenterology, “Victor Babes” University of Medicine and Pharmacy of Timisoara, Romania Background: Employing colonoscopy, the gold standard in colorectal cancer (CRC diagnosis testing, for CRC screening presents a significant risk of complications. Alternative methods with a lower invasive-level and fewer risks are proposed in combination, though each with lower diagnosis performance when applied separately. The main objective of this cross-sectional pilot study was to evaluate the feasibility of a CRC screening program using combined flexible sigmoidoscopy and fecal-immunochemical test (FIT.Methods: The patient population consisted of 2,201 consecutive-case symptomatic patients attending the gastroenterology outpatient clinic with mild complaints between 2012 and 2014. They were referred for FIT. A sample of 252 individuals underwent a subsequent colonoscopy, blind to FIT results, and theoretical sigmoidoscopy was simulated. On a subsample of 57 patients, real sigmoidoscopy was additionally performed. Prior probabilities in terms of patients’ compliance and CRC prevalence were estimated, together with predictive ability of FIT and sigmoidoscopy in screening population. We assessed the merit of a screening strategy employing two-stage serial multiple testing: a first stage by combining two parallel tests, that is, flexible sigmoidoscopy and FIT and b colonoscopy as the second diagnosis test. The scheme was validated using the actual predictive values derived from the study population.Results: Colonoscopy found 75 (29.76% individuals with

  20. Beyond the cloud. Gombrich and the blindness of Orion

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    Lucia Corrain

    2011-12-01

    Full Text Available The contribution departs from the essential and still very much up-to-date article that Ernst Hans Gombrich, as far back as 1944, devoted to Nicolas Poussin’s painting Landscape with Orion. This article offers a meticulous and mythological interpretation of the painting along with the identification of the figures of Orion, Diana and Vulcan, and the artist’s sources. It is on Gombrich’s study that this reading, which focuses on a semiotic analysis of the complex figurative articulation staged by Poussin, is based. The unique rendering of the landscape in the background, the figure of the giant seen from behind in the foreground, the unusual cloud that spreads like a dark stain on the right side of the painting to fall on the eye of the colossus, Orion’s hand at the very centre of the canvas and the lighthouse above the horizon, are all elements of a pictorial system that is complex, but at the same time coherent and significant. As demonstrated here, the theme of Orion’s blindness is bound to that of skill in artistic creation, in a work that becomes a kind of poetic declaration for the peintre-philosophe. The purpose of this essay is to pay tribute to the Viennese art historian, to his everlasting article on the orion, without which we could never even have attempted to gain a better understanding of Poussin’s painting, making an effort in the meantime to put into practice what the French artist had firmly theorized. The opinion put forward here, is that this also reflects how Gombrich worked. The Viennese scholar never stopped at the ‘aspect’ of things, he never stopped before ‘recevoir naturellement dans l’oeil la forme et la rassemblement de la chose vue’, but always tried to see the image with the modality of the poussinian ‘prospect’, that is, beyond the simple receiving of its form in the eye – as the French painter continues – instead searching ‘avec une application particulière les moyen de bien

  1. Caracterización fenotípica de aislamientos de Acinetobacter baumannii en una institución de salud de alta complejidad de Cali

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    Alfredo Prado

    2014-04-01

    Full Text Available Introducción. La caracterización fenotípica de las bacterias del género Acinetobacter mediante pruebas bioquímicas y microscópicas es posible. Varios estudios han demostrado que los aislamientos provenientes de infecciones asociadas a la atención en salud presentan una elevada resistencia a los antibióticos de primera elección. Objetivo. Describir los patrones de resistencia de los aislamientos de Acinetobacter baumannii obtenidos en una institución de salud, así como sus características fenotípicas y los posibles mecanismos de resistencia. Materiales y métodos. Se realizó un estudio descriptivo de corte transversal con 28 informes de muestras tomadas a pacientes hospitalizados con infección por A. baumannii. Las pruebas de sensibilidad para ceftazidime, cefepime, meropenem, amikacina y ciprofloxacina se realizaron con el sistema automatizado Vitek® y la clasificación de sensible, intermedia y resistente se hizo con base en el protocolo establecido por el Clinical and Laboratory Standards Institute para el año 2007. Resultados. El mayor porcentaje de aislamientos correspondió al sexo masculino (53,6 %, a la sala de infectología (28,5 % y al mes de septiembre (21,4 %; el tipo de muestra más frecuente fue el de secreción endotraqueal (53,6 %. A partir de los patrones de los perfiles de sensibilidad a los antibióticos empleados se obtuvieron 13 filotipos. Conclusión. Acinetobacter baumannii es un agente patógeno resistente a múltiples antimicrobianos, involucrado en brotes de infecciones asociadas a la atención en salud. Los patrones de los perfiles de resistencia permiten inferir que los posibles mecanismos de resistencia presentes en la mayoría de los aislamientos son la producción de betalactamasas de espectro extendido, las enzimas modificadoras del antibiótico y la modificación del sitio diana.

  2. Nutritive quality of romanian hemp varieties (Cannabis sativa L.) with special focus on oil and metal contents of seeds.

    Science.gov (United States)

    Mihoc, Marcela; Pop, Georgeta; Alexa, Ersilia; Radulov, Isidora

    2012-10-23

    The study aims to determine the nutritional value of hemp seed expressed by the oil content and by the concentration of metals (Ca, Mg, K, Fe, Mn, Zn and Cd), for five varieties of monoecious and dioecious hemp seeds approved in Romania, comparative with the concentration of these metals in the soil. The content of oil in hempseed registers a slight decrease in the production records of 2011, losses due to drought and low levels of precipitation during the growth period. The greatest loss is found in Diana monoecious variety (26.54-20.82%) followed by Zenit varieties (27.37-22.97%), Armanca (29.27-25.32%), Silvana (28.89-25.04%) and Denise (26.96-25.30%). Siccative hemp oil has a yellowish green color and an iodine index of 140-156 g I2/100 g oil. Hemp seed are rich in mineral based Ca (144-955 mg/100 g seed), Mg (237-694 mg/100 g seed), K (463-2821 mg/100 g seed), Fe (1133-2400 mg.kg-1), Mn (63-110 mg.kg-1) and Zn (42-94 mg.kg-1). For the soil the following macroelements concentrations were determined: Ca (2100-2520 mg.kg-1), Mg (320-376 mg.kg-1) and K (232-257 mg.kg-1). Mn (156-197 mg.kg-1) and Zn (54-67 mg.kg-1) remain within normal limits for Romania. The soils in the experience area contain large amounts of Fe (19000-20430 mg.kg-1). The presence of K in large quantities determines the accumulation of large quantities of Fe in the soil. Hempseed belonging to the five Romanian varieties are rich source of nutrients (Ca, Mg, K) and unsaturated oil easily digestible by the body, but the presence of Cd concentrations above the upper limit puts a question mark over the use of seeds in various food products. Hemp extracts easily certain metals from the soil. Significant amounts of Fe (1133-2400 mg.kg-1), Mn (63-110 mg.kg-1), Zn (42-94 mg.kg-1) and Cd (1.3-4.0 mg.kg-1) are found in hemp seeds. Hemp (Cannabis sativa L.) is included among plants suitable for phytoremediation of soil contaminated with cadmium, zinc and iron.

  3. MicroRNA profiling in intraocular medulloepitheliomas.

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    Deepak P Edward

    Full Text Available To study the differential expression of microRNA (miRNA profiles between intraocular medulloepithelioma (ME and normal control tissue (CT.Total RNA was extracted from formalin fixed paraffin embedded (FFPE intraocular ME (n=7 and from age matched ciliary body controls (n=8. The clinical history and phenotype was recorded. MiRNA profiles were determined using the Affymetrix GeneChip miRNA Arrays analyzed using expression console 1.3 software. Validation of significantly dysregulated miRNA was confirmed by quantitative real-time PCR. The web-based DNA Intelligent Analysis (DIANA-miRPath v2.0 was used to perform enrichment analysis of differentially expressed (DE miRNA gene targets in Kyoto Encyclopedia of Genes and Genomes (KEGG pathway.The pathologic evaluation revealed one benign (benign non-teratoid, n=1 and six malignant tumors (malignant teratoid, n=2; malignant non-teratoid, n = 4. A total of 88 miRNAs were upregulated and 43 miRNAs were downregulated significantly (P<0.05 in the tumor specimens. Many of these significantly dysregulated miRNAs were known to play various roles in carcinogenesis and tumor behavior. RT-PCR validated three significantly upregulated miRNAs and three significantly downregulated miRNAs namely miR-217, miR-216a, miR-216b, miR-146a, miR-509-3p and miR-211. Many DE miRNAs that were significant in ME tumors showed dysregulation in retinoblastoma, glioblastoma, and precursor, normal and reactive human cartilage. Enriched pathway analysis suggested a significant association of upregulated miRNAs with 15 pathways involved in prion disease and several types of cancer. The pathways involving significantly downregulated miRNAs included the toll-like receptor (TLR (p<4.36E-16 and Nuclear Factor kappa B (NF-κB signaling pathways (p<9.00E-06.We report significantly dysregulated miRNAs in intraocular ME tumors, which exhibited abnormal profiles in other cancers as well such as retinoblastoma and glioblastoma. Pathway analysis

  4. Detección de Treponema pallidum subespecie pallidum para el diagnóstico de sífilis congénita mediante reacción en cadena de la polimerasa anidada.

    Science.gov (United States)

    Pinilla, Gladys; Campos, Lesly; Durán, Andrea; Navarrete, Jeannette; Muñoz, Liliana

    2018-03-15

    Introducción. La sífilis es una enfermedad producida por Treponema pallidum subespecie pallidum cuya incidencia mundial es de 12 millones de casos por año, aproximadamente; de estos, más de dos millones se presentan en mujeres gestantes, siendo la sífilis congénita la complicación más grave de esta infección en el embarazo.Objetivo. Detectar la presencia de T. pallidum subespecie pallidum en muestras clínicas para el diagnóstico de sífilis congénita mediante reacción en cadena de la polimerasa (PCR) anidada y determinar su concordancia con las pruebas serológicas.Materiales y métodos. Mediante PCR convencional y anidada, se amplificaron tres genes diana (polA, 16S ADNr y TpN47) y se confirmaron los productos de amplificación de los genes TpN47 y polA por secuenciación. Las pruebas serológicas empleadas fueron la VDRL (Venereal Disease Research Laboratory), la de reagina plasmática rápida (Rapid Plasma Reagin, RPR) y la de aglutinación de partículas para Treponema pallidum (Treponema pallidum Particle Agglutination Assay, TPPA).Resultados. La sensibilidad para la PCR convencional fue de 52 pg y, para la PCR anidada, de 0,52 pg. La especificidad con los iniciadores TpN47 y polA fue de 100 %; los resultados de la secuenciación mostraron una identidad de 97 % con T. pallidum. En 70 % de las muestras, los resultados de las pruebas serológicas y la PCR anidada concordaron.Conclusión. El gen TpN47 resultó ser el mejor blanco molecular para la identificación de T. pallidum. La PCR anidada se presenta como una alternativa de diagnóstico molecular promisoria para el diagnóstico de sífilis congénita.

  5. Effects of 3% trehalose as an adjuvant treatment after LASIK

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    Mateo Orobia AJ

    2017-02-01

    Full Text Available Antonio J Mateo Orobia,1–3 Paula Casas Pascual,1,4 José Á Cristóbal Bescós,1 Diana Perez García,1,4 Carlos Peiro Embid,1,4 M Ángeles del Buey Sayas,1,4 Valentyna Korobko Kulikova,1 Noelia Lafuente Ojeda5 1Department of Ophthalmology, Hospital Quirón, 2Department of Ophthalmology, Hospital Universitario Miguel Servet, 3Instituto de Investigación Sanitaria de Aragón (IIS, 4Department of Ophthalmology, Hospital Clínico Universitario Lozano-Blesa, 5Department of Anesthesiology, Hospital Universitario Miguel Servet, Zaragoza, Spain Purpose: To evaluate the effect of 3% trehalose as an adjuvant in the standard treatment after laser-assisted in situ keratomileusis.Design: Interventional prospective comparative single-blind study.Setting: Department of Ophthalmology, Hospital Quirón Zaragoza, Spain.Methods: A total of 26 eyes (13 patients were included, of which 12 eyes (group 1 received conventional treatment with lubricant drops of hyaluronic acid (0.15% and 14 eyes (group 2 received, additionally, an ophthalmic solution of 3% trehalose. Pre- and postoperative quality-of-life tests and vital stains, tear breakup time, and osmolarity measurements were made.Results: We obtained statistically significant differences between the groups in the Symptom Assessment in Dry Eye test in all visits with respect to severity, and in the postoperative day 1 visit with respect to frequency, in all cases favoring the trehalose treatment. The values of osmolarity were not significantly different between groups. However, we did find significant differences in the Oxford scale in day 90 for the trehalose treatment (P<0.001, and in the National Eye Institute scale in day 30 (P=0.02.Conclusion: The results of this exploratory study indicate that the adjuvant treatment with 3% trehalose could be superior with respect to the standard treatment, with improvements in the objective and subjective parameters of tear quality. Keywords: dry eye syndrome, trehalose

  6. Conocimientos, actitudes y prácticas relacionados con el consumo de sustancias psicoactivas en estudiantes de enfermería de una universidad del departamento del Atlántico (Colombia

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    Julio Melina Castrillo

    2012-01-01

    Full Text Available Objetivo: Establecer los conocimientos, actitudes y prácticas relacionados con el consumo de sustancias psicoactivas en estudiantes de enfermería de una universidad del departamento del Atlántico. Materiales y métodos: Estudio descriptivo transversal; población diana: estudiantes de primero a octavo semestre de enfermería de una universidad del departamento del Atlántico (Colombia. Fuente de información primaria, instrumento utilizado: encuesta de 37 preguntas validada. La información se procesó en el software SPSS, se tabuló en tablas de frecuencia y asociación, gráficas de barras y sectores, la información resumida se manejó en frecuencias relativas, medidas de tendencia central y se determinó significancia estadística mediante proporciones. Resultados: El 71,5% tiene conocimiento sobre la composición de las sustancias psicoactivas. El 45% está totalmente en desacuerdo con el consumo de sustancias psicoactivas para relacionarse fácilmente con la gente. El 37,2% está totalmente en desacuerdo con consumir sustancias psicoactivas para divertirse. El 90,7% está de acuerdo con la inversión de recursos económicos en programas de rehabilitación, seguimiento de la población afectada por el consumo de drogas. El 55,5 % consumé alcohol, el 22,2% consume éxtasis y el 22,2 restante consume marihuana y bazuco. Conclusiones: Se encontró un balance negativo en cuanto al consumo de sustancias psicoactivas en los estudiantes de enfermería, debido a que la gran mayoría ha consumido sustancias psicoactivas. Además de encontrarse deficiencia relacionada al conocimientos de las mismas, y en cuanto a las actitudes, se concluyó que la mayoría de los sujetos estudiados tiene actitudes favorables relacionadas con la legalización de las sustancias psicoactivas.

  7. Update on current management of chronic kidney disease in patients with HIV infection

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    Diana NE

    2016-09-01

    Full Text Available Nina E Diana, Saraladevi Naicker Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Abstract: The prevalence of HIV-associated chronic kidney disease (CKD varies geographically and depends on the definition of CKD used, ranging from 4.7% to 38% globally. The incidence, however, has decreased with the use of effective combined antiretroviral therapy (cART. A wide variety of histological patterns are seen in HIV-associated kidney diseases that include glomerular and tubulointerstitial pathology. In resource-rich settings, there has been a plateau in the incidence of end-stage renal disease secondary to HIV-associated nephropathy (HIVAN. However, the prevalence of end-stage renal disease in HIV-positive individuals has risen, mainly due to increased longevity on cART. There is a disparity in the occurrence of HIVAN among HIV-positive individuals such that there is an 18- to 50-fold increased risk of developing kidney disease among HIV-positive individuals of African descent aged between 20 and 64 years and who have a poorer prognosis compared with their European descent counterparts, suggesting that genetic factors play a vital role. Other risk factors include male sex, low CD4 counts, and high viral load. Improvement in renal function has been observed after initiation of cART in patients with HIV-associated CKD. Treatment with an angiotensin-converting enzyme inhibitor/angiotensin receptor blocker is recommended, when clinically indicated in patients with confirmed or suspected HIVAN or clinically significant albuminuria. Other standard management approaches for patients with CKD are recommended. These include addressing other cardiovascular risk factors (appropriate use of statins and aspirin, weight loss, cessation of smoking, avoidance of nephrotoxins, and management of serum bicarbonate and uric acid, anemia, calcium, and phosphate abnormalities. Early diagnosis of kidney

  8. Batería luria inicial y desarrollo de las funciones psicológicas superiores

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    Yaser Ramírez Benítez

    2014-06-01

    Full Text Available La batería neuropsicológica Luria Inicial es un instrumento válido para evaluar y seguir el desarrollo de las funciones psicológicas superiores en la edad preescolar. El modelo neuropsicológico de Luria ofrece la posibilidad para conocer las funciones superiores del niño. Metodología: La investigación pretende determinar la utilidad clínica del instrumento Luria Inicial en la población cubana preescolar con alteraciones del neurodesarrollo. El objetivo se cumplió con la revisión de los trabajos científicos publicados en la fecha 2006-2013 en bases de datos electrónica (Scielo, EBSCO host, LILACS, Medigraphic. Resultados: El instrumento tiene una efectiva utilidad clínica para conocer el perfil neuropsicológico del niño preescolar con alteraciones del neurodesarrollo. Los resultados en varias poblaciones (TDAH, bajo peso al nacer, desórdenes metabólicos informan que el acto motor con intencionalidad, la inhibición conductual y la organización espacial son habilidades diana a cualquier evento que interrumpan el neurodesarrollo. La adquisición de la función reguladora del habla predice las condiciones preacadémicas del niño en conjunto con el estado real de las funciones superiores. La utilidad clínica del instrumento está en la posibilidad de describir-explicar el estado real de las funciones superiores y su potencial: el niño puede ejecutar e imitar movimientos, dibujar, reconocer los colores y hablar (estado real, pero si no organiza esas ejecuciones a través de la función reguladora del habla (estado potencial estará sujeto a errores y a no aprender por orientaciones del adulto en la etapa escolar. La línea de pensamiento que ofrece Luria para estudiar a los niños es válida y confiable para diagnosticar y rehabilitar las secuelas del sistema nervioso en desarrollo.

  9. Anti-HER2 antibody and ScFvEGFR-conjugated antifouling magnetic iron oxide nanoparticles for targeting and magnetic resonance imaging of breast cancer

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    Chen H

    2013-10-01

    Full Text Available Hongwei Chen,1,* Liya Wang,1,2,* Qiqi Yu,1,2 Weiping Qian,3 Diana Tiwari,1 Hong Yi,4 Andrew Y Wang,5 Jing Huang,1,2 Lily Yang,3 Hui Mao1,2 1Department of Radiology and Imaging Sciences, 2Center for Systems Imaging, 3Department of Surgery, Emory University School of Medicine, 4Robert Apkarian Electron Microscopy Core, Emory University, Atlanta, GA, 5Ocean NanoTech LLC, Springdale, AK, USA *These authors contributed equally to this work Abstract: Antifouling magnetic iron oxide nanoparticles (IONPs coated with block copolymer poly(ethylene oxide-block-poly(γ-methacryloxypropyltrimethoxysilane (PEO-b-PγMPS were investigated for improving cell targeting by reducing nonspecific uptake. Conjugation of a HER2 antibody, Herceptin®, or a single chain fragment (ScFv of antibody against epidermal growth factor receptor (ScFvEGFR to PEO-b-PγMPS-coated IONPs resulted in HER2-targeted or EGFR-targeted IONPs (anti-HER2-IONPs or ScFvEGFR-IONPs. The anti-HER2-IONPs bound specifically to SK-BR-3, a HER2-overexpressing breast cancer cell line, but not to MDA-MB-231, a HER2-underexpressing cell line. On the other hand, the ScFvEGFR-IONPs showed strong reactivity with MDA-MB-231, an EGFR-positive human breast cancer cell line, but not with MDA-MB-453, an EGFR-negative human breast cancer cell line. Transmission electron microscopy revealed internalization of the receptor-targeted nanoparticles by the targeted cancer cells. In addition, both antibody-conjugated and non-antibody-conjugated IONPs showed reduced nonspecific uptake by RAW264.7 mouse macrophages in vitro. The developed IONPs showed a long blood circulation time (serum half-life 11.6 hours in mice and low accumulation in both the liver and spleen. At 24 hours after systemic administration of ScFvEGFR-IONPs into mice bearing EGFR-positive breast cancer 4T1 mouse mammary tumors, magnetic resonance imaging revealed signal reduction in the tumor as a result of the accumulation of the targeted IONPs

  10. The Effectiveness of eHealth Technologies on Weight Management in Pregnant and Postpartum Women: Systematic Review and Meta-Analysis.

    Science.gov (United States)

    Sherifali, Diana; Nerenberg, Kara A; Wilson, Shanna; Semeniuk, Kevin; Ali, Muhammad Usman; Redman, Leanne M; Adamo, Kristi B

    2017-10-13

    .55 kg, 95% CI -3.81 to -1.28) after 3 to 12 months and six studies found a nonsignificant reduction in weight gain for pregnant women (-1.62 kg, 95% CI -3.57 to 0.33) at approximately 40 weeks. This review found evidence for benefits of eHealth technologies on weight management in postpartum women only. Further research is still needed regarding the use of these technologies during and after pregnancy. ©Diana Sherifali, Kara A Nerenberg, Shanna Wilson, Kevin Semeniuk, Muhammad Usman Ali, Leanne M Redman, Kristi B Adamo. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 13.10.2017.

  11. Estudio “Cumple con SAM”

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    Escribá MP

    2009-06-01

    Full Text Available INTRODUCCIÓN Existen estudios que demuestran los beneficios de los sistemas personalizados de dosificación para aumentar la adherencia al tratamiento en pacientes polimedicados. Recientemente se puso en el mercado un sistema de administración de medicamentos (SAM, portable y de pequeño tamaño, que combina un reloj con alarmas programables y varios compartimentos en donde colocar las formas farmacéuticas de los medicamentos. Para la valoración de su utilidad se ha realizado un estudio piloto de satisfacción sobre el SAM entre los pacientes diana de estos dispositivos, solicitando, tras un breve período de uso, su opinión sobre las características del mismo. Se ha evaluando también la mejora del cumplimiento. MATERIAL Y MÉTODOS 43 farmacéuticos comunitarios voluntarios de 26 oficinas de farmacia ubicadas en 5 provincias reclutaron sobre la base de unos criterios de inclusión y exclusión 302 pacientes incumplidores para que utilizasen durante al menos 15 días el SAM y, posteriormente, rellenasen una encuesta de opinión sobre éste. RESULTADOS La opinión del 91% de los pacientes participantes en el estudio es que el SAM es útil, muy útil o imprescindible como sistema de administración de medicamentos. El incumplimiento autocomunicado pasa del 87% al 23% de pacientes. El SAM puede ser útil para los pacientes como sistema de administración de medicamentos en la mejora de la adherencia a su tratamiento farmacológico en la medida en que disminuye los olvidos. Sin embargo, también ponen de manifiesto algunos problemas de diseño mejorables como son el excesivo tamaño, dificultad de apertura e intensidad del sonido. Estos dos últimos problemas dificultan su uso entre la población de mayor edad.

  12. Factores asociados al bajo peso al nacer

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    Georgina J Peraza Roque

    2001-10-01

    Full Text Available El bajo peso al nacer (BPN ha constituido un enigma en la ciencia a través de los tiempos. Múltiples son las investigaciones realizadas acerca de las causas que lo producen y las consecuencias que provoca. Su importancia no solo radica en lo que significa en la morbilidad y la mortalidad infantil, sino que estos niños tienen habitualmente múltiples problemas posteriores. El Programa para la Reducción del BPN señala que los niños nacidos con un peso inferior a los 2 500 g presentan riesgo de mortalidad 14 veces mayor durante el primer año de vida, en comparación con los niños que nacen con un peso normal a término. Dentro de los factores de riesgo del BPN se han encontrado con mayor frecuencia en estudios realizados por diferentes autores, los siguientes: el embarazo en la adolescencia, la desnutrición en la madre, el hábito de fumar, la hipertensión arterial durante el embarazo, la sepsis cervicovaginal, la anemia y los embarazos gemelares, entre otros. Es innegable la influencia que el BPN tiene sobre las futuras generaciones, por lo que debe constituir la diana de los esfuerzos que el médico y la enfermera deben desarrollar en su prevención, sobre todo en la comunidadLow birth weight has been an enigma for Science through times. A lot of research works have been carried out about its causes and consequences. The importance of LBW not only lies in its meaning for infant mortality and morbidity but also in the many problems that low birth weight children regularly face in the future. The program for the reduction of LBW points out that newborns weighing under 2500g have during his/her first year of life a mortality risk 14 times higher than newborns with a normal weight at term. Among the low birth weight risk factors, a number of studies by various authors have frequently found the following; pregnancy at adolescence; undernourishment in mothers, smoking, blood hypertension during pregnancy, cervix-vaginal sepsis; anemia, twin

  13. Profiling analysis of circulating microRNA in peripheral blood of patients with class IV lupus nephritis.

    Directory of Open Access Journals (Sweden)

    Elkin Navarro-Quiroz

    Full Text Available Renal involvement in Systemic Lupus Erythematous (SLE patients is one of the leading causes of morbidity and a significant contributor to mortality. It's estimated that nearly 50% of SLE individuals develop kidney disease in the first year of the diagnosis. Class IV lupus nephritis (LN-IV is the class of lupus nephritis most common in Colombian patients with SLE. Altered miRNAs expression levels have been reported in human autoimmune diseases including lupus. Variations in the expression pattern of peripheral blood circulating miRNAs specific for this class of lupus nephritis could be correlated with the pathophysiological status of this group of individuals. The aim of this study was to evaluate the relative abundance of circulating microRNAs in peripheral blood from Colombian patients with LN-IV. Circulating miRNAs in plasma of patients with diagnosis of LN-IV were compared with individuals without renal involvement (LNN group and healthy individuals (CTL group. Total RNA was extracted from 10 ml of venous blood and subsequently sequenced using Illumina. The sequences were processed and these were analyzed using miRBase and Ensembl databases. Differential gene expression analysis was carried out with edgeR and functional analysis were done with DIANA-miRPath. Analysis was carried out using as variables of selection fold change (≥2 o ≤-2 and false discovery rate (0.05. We identified 24 circulating microRNAs with differential abundance between LN-IV and CTL groups, fourteen of these microRNAs are described for the first time to lupus nephritis (hsa-miR-589-3p, hsa-miR-1260b, hsa-miR-4511, hsa-miR-485-5p, hsa-miR-584-5p, hsa-miR-543, hsa-miR-153-3p, hsa-miR-6087, hsa-miR-3942-5p, hsa-miR-7977, hsa-miR-323b-3p, hsa-miR-4732-3p and hsa-miR-6741-3p. These changes in the abundance of miRNAs could be interpreted as alterations in the miRNAs-mRNA regulatory network in the pathogenesis of LN, preceding the clinical onset of the disease. The findings

  14. Near-Infrared Hyperspectral Image Cubes of Mars during the 1999 Opposition

    Science.gov (United States)

    Hillman, John J.; Glenar, D.; Espenak, F.; Chanover, N.; Murphy, J.; Young, L.; Blass, W.

    1999-01-01

    and Fred Espenak from GSFC, Nancy Chanover, Jim Murphy and A. S. MurTell from NMSU, Leslie Young from BU, Diana Blaney from JPL and Dick Joyce from KPNO.

  15. Obesity, knee osteoarthritis, and polypathology: factors favoring weight loss in older people

    Directory of Open Access Journals (Sweden)

    Isla Pera P

    2016-05-01

    Full Text Available Pilar Isla Pera,1 Ma Carmen Olivé Ferrér,1 Montserrat Nuñez Juarez,2 Esther Nuñez Juarez,3 Loreto Maciá Soler,4 Carmen López Matheu,1 Assumpta Rigol Cuadra,1 María Honrubia Pérez,1 Diana Marre5 1School of Nursing, University of Barcelona, 2Department of Rheumatology, Musculoskeletal Clínic Institute Hospital Clínic, 3Institut Català de la Salut, Barcelona, 4Nursing Department, University of Alicante, Alicante, 5Universitat Autònoma de Barcelona, Barcelona, Spain Aim: We aimed to explore the meaning of obesity in elderly persons with knee osteoarthritis (KO and to determine the factors that encourage or discourage weight loss.Background: Various studies have demonstrated that body mass index is related to KO and that weight loss improves symptoms and functional capacity. However, dietary habits are difficult to modify and most education programs are ineffective.Design: A phenomenological qualitative study was conducted. Intentional sampling was performed in ten older persons with KO who had lost weight and improved their health-related quality of life after participating in a health education program. A thematic content analysis was conducted following the stages proposed by Miles and Huberman.Findings: Participants understood obesity as a risk factor for health problems and stigma. They believed that the cause of obesity was multifactorial and criticized health professionals for labeling them as “obese” and for assigning a moral value to slimness and diet. The factors identified as contributing to the effectiveness of the program were a tolerant attitude among health professionals, group education that encouraged motivation, quantitative dietary recommendations, and a meaningful learning model based on social learning theories.Conclusion: Dietary self-management without prohibitions helped participants to make changes in the quantity and timing of some food intake and to lose weight without sacrificing some foods that were deeply

  16. Barrier protective use of skin care to prevent chemotherapy-induced cutaneous symptoms and to maintain quality of life in patients with breast cancer

    Directory of Open Access Journals (Sweden)

    Wohlrab J

    2014-08-01

    Full Text Available Johannes Wohlrab,1 Nikola Bangemann,2 Anke Kleine-Tebbe,3 Marc Thill,4,5 Sherko Kümmel,6 Eva-Maria Grischke,7 Rainer Richter,8 Sophie Seite,9 Diana Lüftner10 1Martin Luther University Halle-Wittenberg, Department of Dermatology and Venereology, Halle (Saale, 2Interdisciplinary Breast Centre, University Hospital Charité Berlin, Campus Benjamin Franklin, Berlin, Germany, 3Breast Centre DRK Hospital, Berlin, 4Breast Centre University of Lübeck, Department of Gynaecology and Obstetrics, Lübeck, 5Department of Gynaecology and Obstetrics, Agaplesion Markus Hospital, Frankfurt am Main, 6Breast Centre and Clinic of Senology, Hospital Essen-Mitte, Essen, 7Breast Centre University of Tübingen, Department of Gynaecology, Tübingen, 8L'Oréal, Deutschland GmbH, Düsseldorf, 9La Roche-Posay, Dermatological Laboratories, Asnières, France; 10University Hospital Charité Berlin, Campus Benjamin Franklin, Department of Hematology, Oncology and Tumour Immunology, Berlin, Germany Purpose: Chemotherapy with anthracyclines, taxanes, or alkylating agents often causes cutaneous side effects. Nonspecific inhibition of the proliferative activity of keratinocytes has antidifferentiation effects that lead to defects in the barrier function and, thus, to dry, itchy, and irritable skin. These cutaneous symptoms reduce the quality of life of the patients considerably. Conditioning with topical application of niacinamide uses the cytoprotective and barrier stabilizing effect of vitamin B3. Patients and methods: A multicenter randomized crossover study investigated the influence of the test preparation on the quality of life compared to standard care for 73 patients with breast cancer undergoing adjuvant or neoadjuvant cytostatic therapy. Primary target parameter was the Dermatology Life Quality Index with its respective subscales after 6 weeks of a twice-daily application of the respective preparations. Additionally, specific symptoms such as pruritus, dryness, and

  17. Aplicación del Láser Escáner Terrestre (TLS a la modelización de estructuras: precisión, exactitud y diseño de la adquisición de datos en casos reales

    Directory of Open Access Journals (Sweden)

    Ramos, L.

    2015-06-01

    Full Text Available Terrestrial laser scanner is employed in a wide range of engineering applications, because of the specifications of TLS units and the good precision reached. This paper presents the application of TLS to structures and walls modeling. It analyzes the factors that influence final accuracy: cloud registration, target type and the effect of scanning angle and distance. A field test was performed with calibrated panels, obtaining real precision and accuracy values for the most common distance ranges in engineering. We propose and validate the usage of pattern graphs relating precision and accuracy versus distance and scanning angle for field survey design. The application of pattern graph in the design of field scan surveys for dam movement control is also presented. Recommendations are made for the application of TLS technique to large structures.El láser escáner terrestre se emplea en numerosas aplicaciones de Ingeniería, debido a las prestaciones de los equipos y a las precisiones alcanzadas. Se presenta la aplicación del TLS a la modelización de estructuras y paramentos verticales. Se analizan los factores que influyen en la precisión final: registro de nubes, tipo de dianas y el efecto del ángulo y distancia de escaneo. Se realizó una prueba de campo con testigos calibrados, obteniendo valores reales de precisión y exactitud para los rangos de distancia más usuales en Ingeniería. Se propone y valida el empleo de gráficos patrón que relacionan las variables precisión y exactitud con los factores distancia y ángulo de escaneo para el diseño de trabajos de campo. Se expone su aplicación al diseño de los escaneos para el control de movimientos de una presa. Se realizan recomendaciones para la aplicación de la técnica TLS a grandes estructuras.

  18. Economics of Distance and Online Learning Theory, Practice and Research

    Directory of Open Access Journals (Sweden)

    reviewed by TOJDE

    2009-10-01

    Learning: The Role of Embedded Learning inCreating a Competitive Workforce, Jade Nguyen Strattner and Diana OblingerSECTION SIX: OPEN AND VIRTUAL SCHOOLINGChapter 13: Open Basic Education: Organizational Structures, Costs and Benefits,Palitha EdirisinghaSECTION SEVEN: RESEARCH AND DEVELOPMENTChapter 14: From Baobab to Bonsai: Revisiting Methodological Issues in the Costs andEconomics of Distance Education and Distributed e-Learning, Thomas HülsmannSECTION EIGHT: EPILOGUEChapter 15: Implications for Planning and Management of Distance and On-lineLearning, William Bramble and Santosh Panda

  19. Book Reviews

    Directory of Open Access Journals (Sweden)

    Book Review Editor, Barbara Hogenboom

    2014-10-01

    Full Text Available The Economic History of the Caribbean since the Napoleonic Wars, by Victor Bulmer-Thomas (2012; reviewed by Gert OostindieSubjects or Citizens: British Caribbean Workers in Cuba, 1900-1960, by Robert Whitney and Graciela Chailloux Laffita (2013; reviewed by Rose Mary AllenDebating Civil-Military Relations in Latin America, editado por David Mares y Rafael Martínez (2014; reseñado por Raul Benitez-ManautComparative Public Policy in Latin America, editado por Jordi Díez y Susan Franceschet (2012; reseñado por Gonzalo DelamazaEntre el desarrollo y el buen vivir. Recursos naturales y conflictos en los territorios indígenas, editado por José Aylwin, Salvador Martí i Puig, Claire Wright y Nancy Yañez (2013; reviewed by Almut Schilling-VacaflorDignity for the Voiceless. Willem Assies’s Anthropological Work in Context, editado por Ton Salman, Salvador Martí i Puig, y Gemma van der Haar (2014; reseñado por Ricardo Calla OrtegaDemocracy in ‘Two Mexicos’; Political Institutions in Oaxaca and Nuevo León, by Guadelupe Correa-Cabrera (2013; reviewed by Jos BartmanWhere the River Ends, by Shaylih Muehlmann (2013; reviewed by Maria L. Cruz-TorresKnowing History in Mexico. An ethnography of Citizenship, by Trevor Stack (2012; reviewed by Raymond BuveFor God and Revolution. Priest, Peasant, and Agrarian Socialism in the Mexican Huasteca, por Mark Saad Saka( 2013; reseñado por Antonio Escobar OhmstedeWorking Women, Entrepreneurs, and the Mexican Revolution: the Coffee Culture of Córdoba, Veracruz, by Heather Fowler-Salamini (2013; reviewed by Robert F. AlegreWar by Other Means. Aftermath in Post-Genocide Guatemala, edited by Carlota McAlister and Diana Nelson (2013; reviewed by Dirk KruijtLucha revolucionaria. Perú, 1958-1967, por Jan Lust (2013; reseñado por Dirk KruijtWomen in War. The Micro-Processes of Mobilization in El Salvador, by Jocelyn Viterna (2013; reviewed by Ralph SprenkelsZero Hunger: Political Culture and Antipoverty Policy in

  20. Proceedings of Patient Reported Outcome Measure’s (PROMs Conference Sheffield 2016: advances in patient reported outcomes research

    Directory of Open Access Journals (Sweden)

    Tim Croudace

    2016-10-01

    Full Text Available Table of contents S1 Using computerized adaptive testing Tim Croudace S2 Well-being: what is it, how does it compare to health and what are the implications of using it to inform health policy John Brazier O1 “Am I going to get better?”—Using PROMs to inform patients about the likely benefit of surgery Nils Gutacker, Andrew Street O2 Identifying Patient Reported Outcome Measures for an electronic Personal Health Record Dan Robotham, Samantha Waterman, Diana Rose, Safarina Satkunanathan, Til Wykes O3 Examining the change process over time qualitatively: transformative learning and response shift Nasrin Nasr, Pamela Enderby O4 Developing a PROM to evaluate self-management in diabetes (HASMID: giving patients a voice Jill Carlton, Donna Rowen, Jackie Elliott, John Brazier, Katherine Stevens, Hasan Basarir, Alex Labeit O5 Development of the Primary Care Outcomes Questionnaire (PCOQ Mairead Murphy, Sandra Hollinghurst, Chris Salisbury O6 Developing the PKEX score- a multimodal assessment tool for patients with shoulder problems Dominic Marley, James Wilson, Amy Barrat, Bibhas Roy O7 Applying multiple imputation to multi-item patient reported outcome measures: advantages and disadvantages of imputing at the item, sub-scale or score level Ines Rombach, Órlaith Burke, Crispin Jenkinson, Alastair Gray, Oliver Rivero-Arias O8 Integrating Patient Reported Outcome Measures (PROMs into routine primary care for patients with multimorbidity: a feasibility study Ian Porter, Jaheeda Gangannagaripalli, Charlotte Bramwell, Jose M. Valderas O9 eRAPID: electronic self-report and management of adverse-events for pelvic radiotherapy (RT patients Patricia Holch, Susan Davidson, Jacki Routledge, Ann Henry, Kevin Franks, Alex Gilbert, Kate Absolom & Galina Velikova O10 Patient reported outcomes (PROMs based recommendation in clinical guidance for the management of chronic conditions in the United Kingdom Ian Porter, Jose M.Valderas O11 Cross-sectional and