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Sample records for ahmed glaucoma valve

  1. Clinical findings following Ahmed Glaucoma Valve™ implantation in pediatric glaucoma

    OpenAIRE

    Amir Pirouzian; Demer, Joseph L.

    2008-01-01

    Amir Pirouzian1, Joseph L Demer21Department of Ophthalmology, San Diego Children’s Hospital, San Diego, UCSD, San Diego, CA, USA; 2Department of Ophthalmology, Jules Stein Eye Institute, UCLA, Los Angeles, CA, USAPurpose: To describe clinical findings after Ahmed valve drainage implantation in children.Design: All records in one practice were reviewed to identify and describe clinical findings in all children who had undergone Ahmed Glaucoma ValveTM S2 model insertion for uncontroll...

  2. Combined extracapsular cataract extraction with ahmed glaucoma valve implantation in phacomorphic glaucoma

    OpenAIRE

    Das Jaya; Chaudhuri Zia; Bhomaj Sharad; Sharma Pankaj; Gupta Rakesh; Chauhan Deepender

    2002-01-01

    Purpose: To report a retrospective analysis of a combined procedure of extracapsular cataract extraction (ECCE) with heparin surface modified (HSM) posterior chamber intraocular lens (PCIOL) implantation along with primary Ahmed glaucoma valve (AGV) implantation in an attempt to optimize visual acuity gains and intraocular pressure (IOP) control in patients with phacomorphic glaucoma. Methods: ECCE with HSM PC IOL and AGV implantation was performed through two separate incisions in 15 patient...

  3. Combined extracapsular cataract extraction with ahmed glaucoma valve implantation in phacomorphic glaucoma

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    Das Jaya

    2002-01-01

    Full Text Available Purpose: To report a retrospective analysis of a combined procedure of extracapsular cataract extraction (ECCE with heparin surface modified (HSM posterior chamber intraocular lens (PCIOL implantation along with primary Ahmed glaucoma valve (AGV implantation in an attempt to optimize visual acuity gains and intraocular pressure (IOP control in patients with phacomorphic glaucoma. Methods: ECCE with HSM PC IOL and AGV implantation was performed through two separate incisions in 15 patients diagnosed with phacomorphic glaucoma. Postoperative improvement in visual acuity and IOP control were monitored. Results: A steady control of IOP was maintained in all patients with minimum anti-glaucoma medications. The average visual acuity was approximately 6/24 at 3 months. Conclusion: Superior preoperative IOP control and a shorter phacomorphic attack resulted in better postoperative vision. The successful maintenance of IOP within the desired range in this study suggests that the procedure should be performed under similar conditions.

  4. Application of 5-Fluorouracil-Polycaprolactone Sustained-Release Film in Ahmed Glaucoma Valve Implantation Inhibits Postoperative Bleb Scarring in Rabbit Eyes

    OpenAIRE

    Xiu-Zeng Bi; Wei-Hua Pan; Xin-Ping Yu; Zong-Ming Song; Zeng-Jin Ren; Min Sun; Cong-Hui Li; Kai-Hui Nan

    2015-01-01

    This study was designed to investigate whether 5-fluorouracil (5-Fu)-polycaprolactone sustained-release film in Ahmed glaucoma valve implantation inhibits postoperative bleb scarring in rabbit eyes. Eighteen New Zealand white rabbits were randomly divided into three groups (A, B and C; n = 6 per group). Group A received combined 5-Fu-polycaprolactone sustained-release film application and Ahmed glaucoma valve implantation, group B received local infiltration of 5-Fu and Ahmed glaucoma valve i...

  5. Clinical outcomes of trabeculectomy vs. Ahmed glaucoma valve implantation in patients with penetrating keratoplasty : (Trabeculectomy vs. Ahmed galucoma valve in patients with penetrating keratoplasty).

    Science.gov (United States)

    Akdemir, Mehmet Orcun; Acar, Banu Torun; Kokturk, Furuzan; Acar, Suphi

    2016-08-01

    The aim of this study was to compare the visual outcomes, intraocular pressure (IOP), and endothelial cell loss caused by trabeculectomy (TRAB) and Ahmed glaucoma valve (AGV) implantation in patients who had previously undergone penetrating keratoplasty (PKP). The data from all patients who underwent surgical treatment of glaucoma after PKP were reviewed at the Cornea Department of Haydarpasa Numune Education and Research Hospital. Eighteen patients who had undergone surgical treatment of glaucoma after PKP were included in this retrospective study. Time between PKP and glaucoma surgeries, visual acuity results, IOP results, endothelial cell counts (ECC) before the surgery, at 1st, 6th, and 12th month of surgery were recorded. Differences between two groups were evaluated. Mean loss of ECC was 315 cells/mm(2) in the AGV group and 197 cells/mm(2) in TRAB group at 12th month of glaucoma surgery. The difference between endothelial cell loss at 12th month of surgery was statistically significant and higher in AGV group (p < 0.001). The decrease in IOP was 64.2 % in AGV group and 46.9 % in TRAB group at 12th month of surgery. Both differences were statistically significant between 2 groups (p = 0.001, 0.001). TRAB successfully decreased both the IOP and endothelial cell loss in patients with post-PKP glaucoma. Ahmed glaucoma valve had a significantly better IOP lowering but higher endothelial cell loss effect. PMID:26646776

  6. Evaluation of ahmed glaucoma valve implantation through a needle-generated scleral tunnel in Mexican children with glaucoma

    OpenAIRE

    Albis-Donado Oscar; Gil-Carrasco Félix; Romero-Quijada Rafael; Thomas Ravi

    2010-01-01

    Purpose: To evaluate the results and extrusion rates of the Ahmed glaucoma valve (AGV) implantation through a needle-generated scleral tunnel, without a tube-covering patch, in children. Materials and Methods: A retrospective review of the charts of 106 Mexican children implanted with 128 AGVs operated between 1994 and 2002, with the needle track technique, at our institution, with at least six months follow up was done. Main outcome measures were intraocular pressure (IOP) control, tube ex...

  7. Intraocular pressure control after the implantation of a second Ahmed glaucoma valve.

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    Jiménez-Román, Jesús; Gil-Carrasco, Félix; Costa, Vital Paulino; Schimiti, Rui Barroso; Lerner, Fabián; Santana, Priscila Rezende; Vascocellos, Jose Paulo Cabral; Castillejos-Chévez, Armando; Turati, Mauricio; Fabre-Miranda, Karina

    2016-06-01

    The objective of this study is to evaluate the efficacy and safety of a second Ahmed glaucoma valve (AGV) in eyes with refractory glaucoma that had undergone prior Ahmed device implantation. This multicenter, retrospective study evaluated 58 eyes (58 patients) that underwent a second AGV (model S2-n = 50, model FP7-n = 8) due to uncontrolled IOP under maximal medical therapy. Outcome measures included IOP, visual acuity, number of glaucoma medications, and postoperative complications. Success was defined as IOP glaucoma medications preoperatively at 12 and 30 months were 3.17 ± 0.16 (n = 58), 1.81 ± 0.2 (n = 42), and 1.83 ± 0.35 (n = 18), respectively. The reductions in mean IOP and number of medications were statistically significant at all time intervals (P glaucoma, and is associated with relatively few complications. PMID:26334729

  8. Disorder of blood-aqueous barrier following Ahmed Glaucoma Valve implantation

    Institute of Scientific and Technical Information of China (English)

    ZHOU Min-wen; WANG Wei; CHEN Shi-da; HUANG Wen-bin; ZHANG Xiu-lan

    2013-01-01

    Background Ahmed Glaucoma Valve implantation (AGVI) is used to treat refractory glaucoma.Breakdown of the blood-aqueous barrier (BAB) has been noted after some surgical techniques.The current study was designed to assess BAB disruption after AGVI.Methods Anterior chamber protein content was measured by the laser flare cell photometry in 22 eyes of 22 patients with refractory glaucoma before AGVI and at each postoperative visit up to 1 month.Results Before AGVI the mean aqueous flare values in all eyes were (15.17±9.84) photon counts/ms.After AGVI,the values significantly increased at day 1,day 3,and week 1 compared to those before AGVI (all P <0.05) with a peak at day 3.They returned to pre-operative levels at week 2,and were lower than preoperative level at month 1.Eyes with previous intraocular surgery history had greater aqueous flare values than those without previous intraocular surgery history,but there were no significant differences at all time points postoperatively (all P >0.05).Furthermore,eyes with shallow anterior chambers had greater aqueous flare values at day 3 and week 1 (all P <0.05).When comparing eyes with other refractory glaucoma conditions,neovascular glaucoma combined with intravitreal bevacizumab injection resulted in lower aqueous flare values after AGVI,but no significant differences were observed at all time points,postoperatively (all P>0.05).Conclusions The BAB was impaired and inflammation was present in the anterior chamber in refractory glaucomatous eyes following AGVI.However,such conditions were resolved within 1 month postoperatively.Intravitreal bevacizumab treatment in neovascular glaucoma eyes before AGVI may prevent BAB breakdown.

  9. Clinical findings following Ahmed Glaucoma Valve™ implantation in pediatric glaucoma

    OpenAIRE

    Pirouzian, Amir; Demer, Joseph L.

    2008-01-01

    Purpose To describe clinical findings after Ahmed valve drainage implantation in children. Design All records in one practice were reviewed to identify and describe clinical findings in all children who had undergone Ahmed Glaucoma Valve™ S2 model insertion for uncontrolled primary or secondary glaucoma. Results A total of 6 patients were identified, ranging in age from 2–15 years. Mean follow-up time averaged from 2–5 years from the time of tube insertion. Three patients exhibited pupillary ...

  10. Evaluation of ahmed glaucoma valve implantation through a needle-generated scleral tunnel in Mexican children with glaucoma

    Directory of Open Access Journals (Sweden)

    Albis-Donado Oscar

    2010-01-01

    Full Text Available Purpose: To evaluate the results and extrusion rates of the Ahmed glaucoma valve (AGV implantation through a needle-generated scleral tunnel, without a tube-covering patch, in children. Materials and Methods: A retrospective review of the charts of 106 Mexican children implanted with 128 AGVs operated between 1994 and 2002, with the needle track technique, at our institution, with at least six months follow up was done. Main outcome measures were intraocular pressure (IOP control, tube extrusions or exposure and other complications. Results: Kaplan-Meier analysis demonstrated a 96.9% survival rate at six months, 82.4% at one year, 78.7% at two years, 70% at three years and 41.6% at four years. Total success at the last follow-up (IOP between 6 and 21 mm Hg without medications was achieved in 30 eyes (23.5%, 58 eyes (45.3% had qualified success (only topical hypotensive drugs and 40 eyes (31.3% were failures. The mean pre- and post-operative IOP at the last follow up was 28.4 mmHg (SD 9.3 and 14.5 mmHg (SD 6.3, respectively. No tube extrusions or exposures were observed. Tube-related complications included five retractions, a lens touch and a transitory endothelial touch. The risk of failure increased if the eye had any complication or previous glaucoma surgeries. Conclusion: Medium-term IOP control in Mexican children with glaucoma can be achieved with AGV implantation using a needle-generated tunnel, without constructing a scleral flap or using a patch to cover the tube. There were no tube extrusions, nor any tube exposures with this technique.

  11. Clinical findings following Ahmed Glaucoma Valve™ implantation in pediatric glaucoma

    Directory of Open Access Journals (Sweden)

    Amir Pirouzian

    2008-03-01

    Full Text Available Amir Pirouzian1, Joseph L Demer21Department of Ophthalmology, San Diego Children’s Hospital, San Diego, UCSD, San Diego, CA, USA; 2Department of Ophthalmology, Jules Stein Eye Institute, UCLA, Los Angeles, CA, USAPurpose: To describe clinical findings after Ahmed valve drainage implantation in children.Design: All records in one practice were reviewed to identify and describe clinical findings in all children who had undergone Ahmed Glaucoma ValveTM S2 model insertion for uncontrolled primary or secondary glaucoma.Results: A total of 6 patients were identified, ranging in age from 2–15 years. Mean follow-up time averaged from 2–5 years from the time of tube insertion. Three patients exhibited pupillary peaking towards the tube of the valve. All patients required additional surgery or additional medications to control intraocular pressure. Lenticular opacification near the tube site developed in one patient. Gradual tube extrusion was also noted in another two patients.Conclusion: Multiple clinical events follow the Ahmed valve insertion in children. Pupillary irregularity is the most commonly noted event in this series. To avoid or reduce the risk of this complication, additional or modification of surgical procedures could be considered. The mechanism of such occurrence will further be discussed.Keywords: Ahmed Glaucoma Valve, children, pediatric glaucoma

  12. Clinical findings following Ahmed Glaucoma Valve™ implantation in pediatric glaucoma

    Science.gov (United States)

    Pirouzian, Amir; Demer, Joseph L

    2008-01-01

    Purpose To describe clinical findings after Ahmed valve drainage implantation in children. Design All records in one practice were reviewed to identify and describe clinical findings in all children who had undergone Ahmed Glaucoma Valve™ S2 model insertion for uncontrolled primary or secondary glaucoma. Results A total of 6 patients were identified, ranging in age from 2–15 years. Mean follow-up time averaged from 2–5 years from the time of tube insertion. Three patients exhibited pupillary peaking towards the tube of the valve. All patients required additional surgery or additional medications to control intraocular pressure. Lenticular opacification near the tube site developed in one patient. Gradual tube extrusion was also noted in another two patients. Conclusion Multiple clinical events follow the Ahmed valve insertion in children. Pupillary irregularity is the most commonly noted event in this series. To avoid or reduce the risk of this complication, additional or modification of surgical procedures could be considered. The mechanism of such occurrence will further be discussed. PMID:19668395

  13. Boston keratoprosthesis and Ahmed glaucoma valve for visual rehabilitation in congenital anterior staphyloma

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    Bhaskar Srinivasan

    2012-01-01

    Full Text Available Congenital anterior staphyloma entails grave visual prognosis. The majority of reported patients have undergone enucleation. We report a promising result of staphylectomy with implantation of a keratoprosthesis and a glaucoma drainage device in a seven-month-old child with a large, congenital anterior staphyloma.

  14. Pars Plana Ahmed Implantation Combined with 23-gauge Vitrectomy for Refractory Neovascular Glaucoma in Diabetic Retinopathy

    OpenAIRE

    Jeong, Hoon Seok; Nam, Dong Heun; Paik, Hae Jung; Lee, Dae Yeong

    2012-01-01

    Purpose To evaluate the efficacy and safety of a pars plana Ahmed valve implantation combined with 23-gauge sutureless vitrectomy in the treatment of patients with medically uncontrolled neovascular glaucoma (NVG) in proliferative diabetic retinopathy (PDR). Methods The authors retrospectively reviewed the records of 11 consecutive patients with refractory NVG in PDR who underwent a 23-gauge sutureless vitrectomy combined with pars plana placement of an Ahmed valve implant. Control of intraoc...

  15. Application of Ahmed glaucoma valve implantation with sodium hyaluronate on NVG%Ahmed 青光眼阀植入术中联合应用透明质酸钠治疗 NVG

    Institute of Scientific and Technical Information of China (English)

    陈金桃; 叶正辉; 徐志伟

    2014-01-01

    目的:探讨Ahmed青光眼阀植入术治疗新生血管性青光眼( neovascular glaucoma ,NVG)术中联合前房内注入透明质酸钠对手术疗效及术后并发症发生率的影响。  方法:回顾性病例对照研究。选择我院2009/2011年因新生血管性青光眼住院手术的患者49例49眼,按病历号奇偶随机分为两组。对照组行单纯Ahmed青光眼阀植入术,术中前房内不予注入透明质酸钠,研究组术中在将Ahmed青光眼阀硅胶管置入前房前往前房内注入透明质酸钠0.2~0.3mL,术后定期随访1mo,比较两组间术后眼压、最佳矫正视力变化及术后浅前房、前房出血、脉络膜脱离等并发症发生情况。组间手术前后眼压对比采用独立样本秩和检验(非正态分布),组间并发症比较采用χ2检验。  结果:新生血管性青光眼术后随访1 mo ,研究组27眼眼压由42.8±5.56mmHg降至17.7±3.77mmHg,对照组22眼由42.5±5.36 mmHg降至18.6±5.39 mmHg;术后并发症:研究组术后浅前房2例,术后出血1例;对照组术后浅前房4例,术后出血5例,研究组前房硅胶管位置欠佳1例。  结论:Ahmed青光眼阀植入术治疗新生血管性青光眼术中联合前房内注入透明质酸钠,可有效减少术后前房出血的发生,术后短期内会导致患者眼压升高,而对患者远期眼压无明显影响。%AIM: To investigate the effect and complication of sodium hyaluronate combined with Ahmed glaucoma valve implantation on neovascular glaucoma ( NVG) . METHODS:This was a retrospective observational case series.Forty-nine patients ( 49 eyes ) with NVG in our hospital from 2009 to 2011 were randomly divided into two groups according to the odd-even of medical record number.Ahmed glaucoma valve implantation proceeded separately in control group, while in control group combined with 0.2-0.3mL sodium hyaluronate, regularly follow -up after

  16. New continuous air pumping technique to improve clinical outcomes of descemet-stripping automated endothelial keratoplasty in asian patients with previous ahmed glaucoma valve implantation.

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    Chang-Min Liang

    Full Text Available BACKGROUND: To evaluate the outcomes of Descemet-stripping automated endothelial keratoplasty (DSAEK with the use of continuous air pumping technique in Asian eyes with previous Ahmed glaucoma valve implantation. METHODS: The DSAEK procedure was modified in that complete air retention of the anterior chamber was maintained for 10 min using continuous air pumping at 30 mm Hg. The primary outcome measurement was graft survival, and postoperative clinical features including, rate of graft detachment, endothelial cell count, intraocular pressure (IOP, surgical time and cup/disc ratio were also recorded. RESULTS: A total of 13 eyes of 13 patients which underwent modified DSAEK and 6 eyes of 6 patients which underwent conventional DSAEK were included. There was a significant difference in graft survival curves between two groups (P = 0.029; the 1-year graft survival rates were estimated as 100% and 66.7% for patients with modified DSAEK and those with traditional DSAEK, respectively. The rate of graft detachment were 0% and 33.3% for the modified DSAEK and conventional DSAEK groups, respectively (P = 0.088. The significantly lowered surgical time for air tamponade was noted in the modified DSAEK group compared to that in the conventional DSAEK group [median (IQR: 10.0 (10.0, 10.0 min vs. 24.5 (22.0, 27.0 min; P<0.001] Postoperatively, patients in the modified DSAEK group had significantly lower IOP as compared to the conventional DSAEK group [12.0 (11.0, 15.0 mm Hg vs. 16.0 (15.0, 18.0 mm Hg; P = 0.047]. Modified DSAEK patients had higher endothelial cell counts as compared to conventional DSAEK patients [2148.0 (1964.0, 2218.0 vs. 1529.0 (713.0, 2014.0], but the difference did not reach statistical significance (P = 0.072. CONCLUSIONS: New continuous air pumping technique in DSAEK can be performed safely and effectively in patients with prior GDDs placement who have corneal failure.

  17. Ahmed阀植入联合23G玻璃体切除治疗伴玻璃体积血的新生血管性青光眼%Combined Ahmed glaucoma valve implantation and 23-gauge vitrectomy for neovascular glaucoma with vitreous hemorrhage

    Institute of Scientific and Technical Information of China (English)

    王博; 张凤娟; 戴涛; 赵钰; 高传文; 刘建荣; 陈鹏

    2014-01-01

    Objective To evaluate the clinical efficacy of Ahmed glaucoma valve (AGV) implantation combined with transconjunctival sutureless 23-gauge vitrectomy(23G-TSV) for treatment of neovascular glaucoma (NVG) with vitreous hemorrhage.Methods 25 eyes of 25 patients with neovascular glaucoma and vitreous hemorrhage were treated with combined AGV implantation and 23G-TSV.The intraocular pressure(IOP),best corrected visual acuity,success rate and postoperative complications were followed up for 6-12 months.The avevage follow up time was (9.96 ± 1.93) months.Results The IOP was(15.94±6.05),(14.76±2.39),(17.12±6.06),(17.44±2.75) and (18.96 ± 3.56) mmHg (1 mm Hg =0.133 kPa) at 1 day,1 week,1 month,3 months and the last follow-up postoperatively.Compared with pre-operative IOP of (48.12 ± 7.29) mmHg,the IOP was significantly(t =16.733,P < 0.05 ; t =21.961,P<0.05;t =16.917,P<0.05 ;t =17.609,P<0.05 ;t =18.091,P<0.05)decreased after surgery; The total success rate was 84.0% at final follow-up; The visual acuity was improved in all patients.Conclusion AGV implantation combined with 23G-TSV is effective for treating NVG with vitreous hemorrhage.%目的 评价Ahmed青光眼引流阀植入联合23G玻璃体切除术治疗伴玻璃体积血的新生血管性青光眼的效果.方法 对25例(25眼)伴玻璃体积血的新生血管性青光眼采用Ahmed阀植入联合23G玻璃体切除术治疗,统计分析术后不同时间眼压、手术成功率、最佳矫正视力及并发症,术后随访6 ~12个月,平均(9.96±1.93)月.结果 术后1d、1周、1个月、3个月和最后一次随访时平均眼压分别为(15.94±6.05)、(14.76±2.39)、(17.12±6.06)、(17.44±2.75)及(18.96±3.56) mmHg(1 mmHg=0.133 kPa).与术前平均眼压(48.12±7.29)mmHg比较,差异有统计学意义(t=16.733、21.961、16.917、17.609及18.091,P<0.05);最后一次随访时手术总成功率为84.0%.所有患者视力均有提高.结论 Ahmed阀植入联合23G玻璃体切除术是

  18. A novel implantable glaucoma valve using ferrofluid.

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    Eleftherios I Paschalis

    Full Text Available PURPOSE: To present a novel design of an implantable glaucoma valve based on ferrofluidic nanoparticles and to compare it with a well-established FDA approved valve. SETTING: Massachusetts Eye & Ear Infirmary, Boston, USA. METHODS: A glaucoma valve was designed using soft lithography techniques utilizing a water-immiscible magnetic fluid (ferrofluid as a pressure-sensitive barrier to aqueous flow. Two rare earth micro magnets were used to calibrate the opening and closing pressure. In-vitro flow measurements were performed to characterize the valve and to compare it to Ahmed™ glaucoma valve. The reliability and predictability of the new valve was verified by pressure/flow measurements over a period of three months and X-ray diffraction (XRD analysis over a period of eight weeks. In vivo assessment was performed in three rabbits. RESULTS: In the in vitro experiments, the opening and closing pressures of the valve were 10 and 7 mmHg, respectively. The measured flow/pressure response was linearly proportional and reproducible over a period of three months (1.8 µl/min at 12 mmHg; 4.3 µl/min at 16 mmHg; 7.6 µl/min at 21 mmHg. X-ray diffraction analysis did not show oxidization of the ferrofluid when exposed to water or air. Preliminary in vivo results suggest that the valve is biocompatible and can control the intraocular pressure in rabbits. CONCLUSIONS: The proposed valve utilizes ferrofluid as passive, tunable constriction element to provide highly predictable opening and closing pressures while maintaining ocular tone. The ferrofluid maintained its magnetic properties in the aqueous environment and provided linear flow to pressure response. Our in-vitro tests showed reliable and reproducible results over a study period of three months. Preliminary in-vivo results were very promising and currently more thorough investigation of this device is underway.

  19. In vitro experiment of the pressure regulating valve for a glaucoma implant

    Science.gov (United States)

    Bae, Byunghoon; Kee, Hongseok; Kim, Seonho; Lee, Yeon; Sim, Taeseok; Kim, Yongkweon; Park, Kyihwan

    2003-09-01

    Glaucoma is an eye disease which is caused by abnormal high intraocular pressure (IOP) in the eye. If the condition of the patient becomes serious, the use of an implant device is recommended, which decreases the IOP compulsory. Active implants for glaucoma implants are capable of controlling the IOP actively and coping with the personal differences of patients. However, the conventional active valves for the glaucoma implant are not convenient for the patient and feasibility is not shown for the glaucoma treatment. In this paper, we propose, analyze, fabricate and experiment on the pressure regulating valve for the active implant. Based on the analysis, we carry out optimal design of the proposed valve. The in vitro experiments are performed extensively both using and not using a rabbit in open- and closed-loop pressure control. The various experimental results verify the possibility of the proposed valve for a glaucoma implant.

  20. The Anesthetic Implications of Aqueous Drainage Devices and Glaucoma: A Report of a Patient Undergoing Urgent Prone Cervical Decompression and Fusion.

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    Blackney, Kevin A; Zavodni, Zachary J; Saddawi-Konefka, Daniel

    2016-08-01

    The pathophysiology of glaucoma and perioperative visual loss is similar. A patient with glaucoma may be at increased risk of perioperative visual loss. For both, goals of management include optimizing ocular perfusion pressure and oxygen delivery. One treatment for refractory glaucoma is an aqueous drainage device; however, there is no published literature on the anesthetic management of patients with these devices. We present the case of a patient with recalcitrant glaucoma treated with an Ahmed Glaucoma Valve who underwent urgent prone surgery. Anesthetic implications of aqueous drainage devices and glaucoma are discussed, and recommendations are made. PMID:27258174

  1. Alterations in the aqueous humor proteome in patients with a glaucoma shunt device

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    Anshu, Arundhati; Price, Marianne O; Richardson, Matthew R; Segu, Zaneer M.; Lai, Xianyin; Yoder, Mervin C.; Price, Francis W.

    2011-01-01

    Purpose To investigate whether implantation of a glaucoma shunt device leads to inappropriate accumulation of plasma derived proteins in the aqueous humor. Methods Aqueous humor samples were collected from 11 patients (study group) with a glaucoma shunt device undergoing either cataract surgery or a corneal transplant and 11 patients (control) with senile cataract undergoing routine cataract extraction. Of the study group, 9 had an Ahmed valve implant and 2 eyes had a Baerveldt implant. Trypt...

  2. Late onset endophthalmitis associated with unexposed glaucoma valved drainage device.

    Science.gov (United States)

    AlHadlaq, Abdulaziz; AlMalki, Salem; AlShahwan, Sami

    2016-01-01

    We report an extremely rare presentation of late-onset endophthalmitis in a young adult patient with an unexposed Ahmed tube implant. The implant was inserted 11 years prior to presentation. There was no history of trauma or any obvious exposure on clinical examination and the tube plate was filled with purulent material. After aqueous and vitreous tap, the patient underwent intracameral, intravitreal subconjunctival antibiotic injections and was started on systemic antibiotics with good response. Endophthalmitis associated with tube drainage device can present as late as 11 years and even without an unexposed tube. PMID:27330390

  3. Glaucoma

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    Glaucoma is a group of diseases that can damage the eye's optic nerve. It is a leading ... no symptoms at first. Without treatment, people with glaucoma will slowly lose their peripheral, or side vision. ...

  4. Glaucoma

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    Full Text Available ... Eye Disease Dilated Eye Exam Dry Eye For Kids Glaucoma Healthy Vision Tips Leber Congenital Amaurosis Low Vision Refractive Errors Retinopathy of Prematurity Science Spanish Videos Webinars NEI YouTube Videos: Glaucoma NEI ...

  5. Secondary glaucoma in CAPN5-associated neovascular inflammatory vitreoretinopathy

    Science.gov (United States)

    Cham, Abdourahman; Bansal, Mayank; Banda, Himanshu K; Kwon, Young; Tlucek, Paul S; Bassuk, Alexander G; Tsang, Stephen H; Sobol, Warren M; Folk, James C; Yeh, Steven; Mahajan, Vinit B

    2016-01-01

    Objective The objective of this study was to review the treatment outcomes of patients with secondary glaucoma in cases of autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV), a hereditary autoimmune uveitis due to mutations in CAPN5. Patients and methods A retrospective, observational case series was assembled from ADNIV patients with secondary glaucoma. The main outcome measures were intraocular pressure (IOP), visual acuity, use of antiglaucoma medications, ocular surgeries, and adverse outcomes. Perimetry and optic disk optical coherence tomography (OCT) were also analyzed. Results Nine eyes of five ADNIV patients with secondary glaucoma were reviewed. Each received a fluocinolone acetonide (FA) implant for the management of posterior uveitis. Following implantation, no eyes developed neovascular glaucoma. Five eyes (in patients 1, 2, and 5) required Ahmed glaucoma valve surgery for the management of steroid-responsive glaucoma. Patient 2 also developed angle closure with iris bombe and underwent laser peripheral iridotomy. Patient 4 had both hypotony and elevated IOP that required periodic antiglaucoma medication in the FA-implanted eye. Patient 3 did not develop steroid-response glaucoma in either eye. Optic disk examinations were obscured by fibrosis and better assessed with OCT. Conclusion ADNIV patients show combined mechanism secondary glaucoma best assessed by OCT of the optic disk. The FA implants have reduced uveitic and neovascular glaucoma. Nevertheless, IOP management remains complex due to steroid-response glaucoma, angle closure glaucoma, and hypotony. PMID:27390515

  6. Glaucoma Surgery in Pregnancy: A Case Series and Literature Review.

    Science.gov (United States)

    Razeghinejad, Mohammad Reza; Masoumpour, Masoumeh; Eghbal, Mohammad Hossein; Myers, Jonathan S; Moster, Marlene R

    2016-09-01

    Glaucoma management in pregnant patients is a real challenge, especially when the glaucoma is not controlled with medications. We report the results of 6 incisional glaucoma surgeries for the management of medically uncontrolled glaucoma patients during pregnancy. This retrospective, case series was conducted on the 6 eyes of 3pregnant patients with uncontrolled glaucoma using maximum tolerable medications. Details of the glaucoma surgical management of these patients as well as their postoperative care and pregnancy and clinical outcomes on longitudinal follow-up are discussed. All 3 patients had juvenile open-angle glaucoma and were on various anti-glaucoma medications, including oral acetazolamide. The first case described underwent trabeculectomy without antimetabolites in both eyes because of uncontrolled intraocular pressure with topical medications. The surgery was done with topical lidocaine jelly and subconjunctival lidocaine during the second and third trimesters. The second patient had an Ahmed valve implantation in both eyes during the second and third trimesters because of uncontrolled IOP with topical medications and no response to selective laser trabeculoplasty. Surgery was done with topical tetracaine and subconjunctival and sub-Tenon's lidocaine. The third case had a Baerveldt valve implantation under general anesthesia in the second trimester. In selected pregnant glaucoma patients with medically uncontrolled intraocular pressure threatening vision, incisional surgery may lead to good outcomes for the patient with no risk for the fetus. PMID:27582594

  7. Glaucoma

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    Full Text Available ... the Scientific Director Office of the Clinical Director Education Programs All Education National Eye Health Education Program Diabetic Eye Disease Education Program Glaucoma Education ...

  8. Glaucoma

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    Full Text Available ... NEI YouTube Videos > NEI YouTube Videos: Glaucoma NEI YouTube Videos YouTube Videos Home Age-Related Macular Degeneration ... Retinopathy of Prematurity Science Spanish Videos Webinars NEI YouTube Videos: Glaucoma NEI on Twitter NEI on YouTube ...

  9. Glaucoma

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  11. Glaucoma

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  12. Glaucoma

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    Full Text Available ... Programs All Education National Eye Health Education Program Diabetic Eye Disease Education Program Glaucoma Education Program Low ... Macular Degeneration Amblyopia Animations Blindness Cataract Convergence Insufficiency Diabetic Eye Disease Dilated Eye Exam Dry Eye For ...

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  14. Glaucoma

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    Full Text Available ... NEI All Research at NEI Office of the Scientific Director Office of the Clinical Director Education Programs ... Amaurosis Low Vision Refractive Errors Retinopathy of Prematurity Science Spanish Videos Webinars NEI YouTube Videos: Glaucoma NEI ...

  15. Glaucoma

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    Full Text Available ... Amaurosis Low Vision Refractive Errors Retinopathy of Prematurity Science Spanish Videos Webinars NEI YouTube Videos: Glaucoma NEI ... questions and comments to the NEI Office of Science Communications, Public Liaison, and Education. Technical questions about ...

  16. Glaucoma

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    Full Text Available ... History of the NEI Donating to the NEI Health Information Diseases and Disorders Clinical Studies Publications Catalog ... Clinical Director Education Programs All Education National Eye Health Education Program Diabetic Eye Disease Education Program Glaucoma ...

  17. Glaucoma

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  18. Conjunctival erosion after glaucoma drainage device surgery: A feasible option

    Directory of Open Access Journals (Sweden)

    Suneeta Dubey

    2013-01-01

    Full Text Available Glaucoma drainage devices (GDDs have been used in the management of complicated glaucomas. GDDs are associated with various complications such as tube migration, tube or plate exposure or extrusion, ocular motility disturbance and infection. Erosion of conjunctiva and exposure of the GDD remains a risk factor for the development of endophthalmitis. A wide range of materials have been used for this purpose, including sclera, dura, pericardium, fascia lata and cornea. However, there is no evidence to prove that any of these methods is superior to another for providing tectonic durability in the long term. In this report, we present a case of neovascular glaucoma, who developed conjunctival melting over the tube of an Ahmed Glaucoma Valve implant and was successfully managed with Cap Doxycycline.

  19. Polymeric check valve with an elevated pedestal for precise cracking pressure in a glaucoma drainage device.

    Science.gov (United States)

    Park, Chang-Ju; Yang, Dong-Seong; Cha, Jung-Joon; Lee, Jong-Hyun

    2016-02-01

    This paper presents the design, fabrication, and characterization of a polymeric micro check valve for a glaucoma drainage device (GDD) featuring the precise regulation of intraocular pressure (IOP) and effective aqueous humor turnover (AHT). The pedestal, slightly elevated by selective coating of a parylene C film, induces pre-stress in the thin valve membrane, which enhances the predictability of the cracking pressure of the GDD. The proposed GDD comprises a cannula and a normally closed polymeric micro check valve, which are made of PDMS, a biocompatible polymer, with three layers: top (cover), intermediate (thin valve membrane), and bottom (base plate). A feedback channel, located between the top and intermediate layers, prevents reverse flow by feeding the pressure of the outlet channel back to the thin valve membrane. To achieve a precise cracking pressure and sufficient drainage of humor for humans, the thicknesses of the valve membrane and parylene C film are designed to be 58 μm and 1 μm, respectively, which are confirmed using a COMSOL simulation. The experimental results show that the cracking pressure of the fabricated GDD lies within the range of normal IOP (1.33-2.67 kPa). The forward flow rate (drainage rate), 4.3 ± 0.9 μL/min at 2.5 kPa, is adequate to accommodate the rate of AHT in a normal human eye (2.4 ± 0.6 μL/min). The reverse flow was not observed when a hydrostatic pressure of up to 4 kPa was applied to the outlet and the feedback channel. PMID:26864969

  20. Glaucoma

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    Full Text Available ... Vision Research & Ophthalmology (DIVRO) Student Training Programs NEI Home About NEI Health Information News and Events Grants ... Research at NEI Education Programs Training and Jobs Home > NEI YouTube Videos > NEI YouTube Videos: Glaucoma NEI ...

  1. Glaucoma

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    Full Text Available ... Topics Clinical Studies Publications Catalog Photos and Images Spanish Language Information News and Events All News Meetings ... Program Glaucoma Education Program Low Vision Education Program Spanish-language Education Program (¡Ojo con su visión!) Vision ...

  2. Glaucoma

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    Full Text Available ... Disorders Clinical Studies Publications Catalog Photos and Images Spanish Language Information Frequently Asked Questions News and Events ... Program Glaucoma Education Program Low Vision Education Program Spanish-language Education Program (¡Ojo con su visión!) Vision ...

  3. Glaucoma

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    Full Text Available ... Supported by the NEI Research at NEI All Research at NEI Office of the Scientific Director Office of the Clinical Director Education Programs ... Health Information News and Events Grants and Funding Research at NEI Education Programs Training and ... YouTube Videos: Glaucoma NEI ...

  4. Glaucoma

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    Full Text Available ... Clinical Studies Publications Catalog Photos and Images Spanish Language Information Frequently Asked Questions News and Events All ... Glaucoma Education Program Low Vision Education Program Spanish-language Education Program (¡Ojo con su visión!) Vision and ...

  5. Glaucoma

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    Full Text Available ... Macular Degeneration Amblyopia Animations Blindness Cataract Convergence Insufficiency Diabetic Eye Disease Dilated Eye Exam Dry Eye For Kids Glaucoma Healthy Vision Tips Leber Congenital Amaurosis Low Vision Refractive Errors Retinopathy of Prematurity Science Spanish Videos Webinars NEI YouTube ...

  6. Long-term results of non-valved Glaucoma drainage implant surgery and glaucoma drainage implant combined with trabeculectomy

    Directory of Open Access Journals (Sweden)

    Teruhiko Hamanaka

    2014-01-01

    Full Text Available Purpose: The purpose was to investigate the efficacy and complications of nonvalved glaucoma drainage implant (GDI surgery and GDI combined with trabeculectomy. Subjects and Methods: Serial Japanese patients who received GDI were retrospectively investigated. The survival rate of eyes was analyzed using the Kaplan-Meier method, defining death as: (1 Intraocular pressure (IOP <6 mmHg, or ≥22 mmHg, and <20% reduction of preoperative IOP, (2 additional glaucoma surgery, (3 loss of light perception. Prognostic factors of age, sex, previous surgery, type of glaucoma, synechial closure, preoperative IOP, type of GDI (single-, double-plate Molteno, Baerveldt 350 and GDI combined with trabeculectomy were investigated employing proportional hazards analysis. Results: One hundred and twenty-four eyes of 109 patients aged 53.3 ± 7.8 years old were analyzed. Types of GDI were single-plate (15.3%, double-plate Molteno (71.8%, and Baerveldt 350 (12.9%. The results of survival rate analysis were 86.1, 71.1, 71.1, and 64.6% for 1, 3, 5, and 10 years respectively. Thirty-four eyes (27.4% died because of uncontrolled IOP (19.4%, loss of light perception (5.6%, and additional glaucoma surgery (2.4%. Single-plate Molteno was the only risk factor for failure. Persistent unphysiological hypotony (0.8% and bullous keratopathy (5.6% were observed. Conclusion: Nonvalved GDI surgery and GDI combined with trabeculectomy using nonabsorbable tube ligature proved to be an excellent device for any type of glaucoma in Japanese patients. Hypotony and corneal endothelial loss are the most serious complication in the long-term results of our patients.

  7. Flow around Ahmed Body

    Czech Academy of Sciences Publication Activity Database

    Uruba, Václav; Sedlák, K.

    Praha : Ústav termomechaniky AV ČR, v. v. i., 2009 - (Příhoda, J.; Kozel, K.), s. 107-110 ISBN 978-80-87012-19-2. [Topical Problems of Fluid Mechanics 2009. Praha (CZ), 25.02.2009-26.02.2009] R&D Projects: GA ČR GA101/08/1112 Institutional research plan: CEZ:AV0Z20760514 Keywords : Ahmed body * dynamics * wake Subject RIV: BK - Fluid Dynamics

  8. Methods to reduce intraocular pressure on secondary glaucoma after severe eye burns

    Directory of Open Access Journals (Sweden)

    A. V. Solovieva

    2014-07-01

    Full Text Available Purpose: Show the results of treatment of secondary glaucoma after severe eye burns.Methods: We observed 70 patients (108 eyes with severe burns the eyes and their consequences, secondary glaucoma was observed in 40 patients (58 eyes. All patients with secondary glaucoma received traditional antihypertensive therapy, with its failure to resort to antiglaucomatous surgery. Cataract extraction performed in 24 cases, 16 of them in combination with other surgery: the reconstruction of the anterior chamber, penetrating keratoplasty, sinustrabeculectomy, diode laser cyclocoagulation. Diode laser cy- clocoagulation performed 42 times in 8 of them in combination with other antiglaucomatous surgery: cataract surgery, reconstruction of the anterior chamber. Sinustrabeculectomy in patients with secondary glaucoma was performed in 7 cases, 4 of them with collagen implant drainage. Ahmed glaucoma drainage implant performed in 5 cases.Results: In 23 out of 58 (39.6% of long-term compensation glaucoma IOP was achieved antihypertensive therapy without sur- gery. After cataract extraction resistant compensated IOP was achieved in 10 cases, a temporary (1 to 42 months — in 11 cases, IOP is not reduced in 2 cases. After completing diode laser cyclocoagulation stable normalization of IOP occurred in 16 cases, the temporary (from 1 month to 2 years — in 20 cases, 4 cases of IOP reduction was not achieved. As a result sinustrabeculectomy in 4 cases IOP decreased, in one case the hypotensive effect is not there. After implantation Ahmed glaucoma valve in 2 cases was achieved stable normalization of IOP, in the 2 cases — the temporary; in 1 case developed endophthalmitis, and the device was removed.Conclusion: the immediate effect of antiglaucomatous treatment was 96.6%, but the high incidence of IOP decompensation (73.7% suggesting the need for continuous follow-up patients after severe eye burn injury, and a readiness to use other methods to reduce IOP.

  9. Secondary glaucoma in CAPN5-associated neovascular inflammatory vitreoretinopathy

    Directory of Open Access Journals (Sweden)

    Cham A

    2016-06-01

    Full Text Available Abdourahman Cham,1,2 Mayank Bansal,3 Himanshu K Banda,4 Young Kwon,1 Paul S Tlucek,1 Alexander G Bassuk,5 Stephen H Tsang,6,7 Warren M Sobol,8 James C Folk,1 Steven Yeh,4 Vinit B Mahajan1,2 1Department of Ophthalmology and Visual Sciences, 2Omics Laboratory, University of Iowa, Iowa City, IA, USA; 3Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India; 4Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, 5Department of Pediatrics, University of Iowa, Iowa City, IA, 6Barbara and Donald Jonas Laboratory of Stem Cells and Regenerative Medicine and Bernard and Shirlee Brown Glaucoma Laboratory, Department of Pathology and Cell Biology, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, 7Edward S Harkness Eye Institute, New York-Presbyterian Hospital, New York, NY, 8Retina Physicians & Surgeons, Inc., Dayton, OH, USA Objective: The objective of this study was to review the treatment outcomes of patients with secondary glaucoma in cases of autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV, a hereditary autoimmune uveitis due to mutations in CAPN5. Patients and methods: A retrospective, observational case series was assembled from ADNIV patients with secondary glaucoma. The main outcome measures were intraocular pressure (IOP, visual acuity, use of antiglaucoma medications, ocular surgeries, and adverse outcomes. Perimetry and optic disk optical coherence tomography (OCT were also analyzed. Results: Nine eyes of five ADNIV patients with secondary glaucoma were reviewed. Each received a fluocinolone acetonide (FA implant for the management of posterior uveitis. Following implantation, no eyes developed neovascular glaucoma. Five eyes (in patients 1, 2, and 5 required Ahmed glaucoma valve surgery for the management of steroid-responsive glaucoma. Patient 2 also developed angle closure with iris bombe and underwent laser

  10. On the Ahmed Body Wake

    Czech Academy of Sciences Publication Activity Database

    Uruba, Václav; Hladík, Ondřej

    Praha : Ústav termomechaniky AV ČR v. v. i., 2009 - (Jonáš, P.; Uruba, V.), s. 51-52 ISBN 978-80-87012-21-5. [Colloquium Fluid Dynamics 2009. Praha (CZ), 21.10.2009-23.10.2009] R&D Projects: GA ČR GA101/08/1112 Institutional research plan: CEZ:AV0Z20760514 Keywords : Ahmed body * wake * dynamics Subject RIV: BK - Fluid Dynamics

  11. Conjunctival inclusion cyst following repair of tube erosion in a child with aphakic glaucoma, leading to endophthalmitis

    Directory of Open Access Journals (Sweden)

    Roy, Avik Kumar

    2015-05-01

    Full Text Available Introduction: Glaucoma in aphakia is a major long term complication following congenital cataract surgery. Implantation of glaucoma drainage device provides an effective approach to manage refractory paediatric glaucoma. However implant surgery in young individuals is not free of complications. The prompt detection and management of tube erosion is of utmost importance to prevent devastating sequel of endophthalmitis. Implantation cyst following repair of tube erosion has not been reported so far. This case illustrates the rare occurrence of inclusion cyst following repair of tube erosion, the possible causes and its consequences. Case description: A 2-year-old child with aphakia developed intractable glaucoma. Following a failed glaucoma filtering surgery he underwent sequential Ahmed Glaucoma Valve implantation in both the eyes. Six weeks following right eye surgery, the child presented with conjunctival erosion overlying the tube, which was treated with scleral patch graft and conjunctival advancement. One month after the repair of tube erosion, the child presented with implantation cyst under the scleral patch graft, which was treated by drainage with a 29G needle. The child presented with endophthalmitis of his right eye following an episode of bilateral conjunctivitis. This was managed by an emergency pars plana vitrectomy, intraocular antibiotics and tube excision. At the last follow up visit, the IOP was 20 mmHg with 2 topical antiglaucoma medications in the right eye following a trans scleral photocoagulation.Discussion: Lifelong careful follow-up of paediatric eyes with implant surgery is mandatory to look for complication such as tube erosion. It is important to place additional sutures to secure the patch graft during implantation of glaucoma drainage devices in children to prevent graft displacement and consequent tube erosion. During repair of tube erosion, it is crucial to remove all the conjunctival epithelium around the tube

  12. Glaucoma Symptoms

    Science.gov (United States)

    ... up You can help find a cure for glaucoma Give now Signs & Symptoms The most common types ... have completely different symptoms. Symptoms of Open-Angle Glaucoma Most people who develop open-angle glaucoma don’ ...

  13. Glaucoma (image)

    Science.gov (United States)

    Glaucoma is a condition of increased fluid pressure inside the eye. The increased pressure causes compression of ... nerve which can eventually lead to nerve damage. Glaucoma can cause partial vision loss, with blindness as ...

  14. Glaucoma Foundation

    Science.gov (United States)

    ... Options: SIZE CONTRAST Search Home About TGF About Glaucoma About Exfoliation Syndrome Research Center Contact Us Get ... be allergy season. For those who live with glaucoma, it’s especially important to manage the symptoms. Seasonal ...

  15. Flow in Wake of Ahmed Body

    Czech Academy of Sciences Publication Activity Database

    Uruba, Václav; Knob, Martin; Sedlák, K.

    -, č. 6 (2009), s. 266-269. ISSN 1335-2938. [Stretnutie katedier mechaniky tekutín a termomechaniky. Jasná, Demanovská dolina, 24.06.2009-26.06.2009] R&D Projects: GA ČR GA101/08/1112 Institutional research plan: CEZ:AV0Z20760514 Keywords : Ahmed body * wake * PIV * FLUENT Subject RIV: BK - Fluid Dynamics

  16. AHMED Code comparison exercise: comparison report

    International Nuclear Information System (INIS)

    The NEA Committee on the Safety of Nuclear Installations (CSNI) sponsored in 1994/1995 a code comparison exercise based on NaOH tests performed in VTT's AHMED (Aerosol and Heat Transfer Measurement Device) facility with the objective of testing containment aerosol codes in well defined conditions prior to the VANAM standard problem, where aerosol behavior has been studied in a large scale multi-compartment facility. For the code users it is important to know how well their codes can predict experimental results in AHMED's well defined conditions before their codes are compared with aerosol behaviour measured in large scale facilities where the driving forces are merely the thermal-hydraulics. In other words, comparisons against well controlled thermal-hydraulic and aerosol source conditions, as in the AHMED tests, provide the code user a better understanding of the effects of certain aspects of the aerosol modelling used in the codes, that can be gained from comparisons of tests in large scale facilities. Calculated results from 6 different codes and 6 different institutes: CONTAIN 1.12 (JRC, VTT, ECN), FIPLOC-MI (GRS), IDRA 4.1 (ENEA), MACRES (NUPEC), MELCOR 1.8.3 or 1.8.2 (ENEA, ECN, VTT) and NAUAHYGROS 1.1 (VTT) were submitted (ECN results were submitted after the preparation of the first draft of this report). The codes used for the analyses of this comparison exercise represent a wide spectrum of the containment codes that are used for severe accident analyses

  17. Pirfenidone inhibits fibrosis in foreign body reaction after glaucoma drainage device implantation

    Science.gov (United States)

    Jung, Kyoung In; Park, Chan Kee

    2016-01-01

    Background The aim of this study was to investigate the antiscarring effects of pirfenidone on foreign body reaction in a rabbit model of glaucoma drainage implant surgery. Methods Adult New Zealand White rabbits had glaucoma drainage device implantation using Model FP8 Ahmed glaucoma valves. One eye was randomly assigned to receive postoperative intrableb injection of pirfenidone followed by topical treatment. The other eye underwent the same procedure but without the addition of pirfenidone. Histochemical staining and immunohistochemistry for blebs were performed. Results The degree of cellularity was smaller in the pirfenidone group than in the control group at 2 weeks post operation (P=0.005). A few foreign body giant cells were detected in the inner border of the capsule, and their numbers were similar in the control and pirfenidone groups (P>0.05). Using Masson’s trichrome stain, the inner collagen-rich layer was found to be thinner in the pirfenidone group than the control group at 4 weeks (P=0.031) and 8 weeks (P=0.022) post operation. The percentage of proliferating cell nuclear antigen-positive cells was lower in the pirfenidone group than in the control group at 2 weeks post operation (total bleb, P=0.022; inner bleb, P=0.036). Pirfenidone treatment decreased the immunoreactivity of connective tissue growth factor at 2 weeks post operation (total bleb, P=0.029; inner bleb, P=0.018). The height and area of α-smooth muscle actin expression were lower in the pirfenidone group than the control group at 2 weeks, 4 weeks, and 8 weeks post operation (all Pglaucoma drainage device implantation. These findings suggest that pirfenidone may function as an antiscarring treatment in foreign body reaction after tube-shunt surgery. PMID:27143855

  18. Ahmed Kanna, Dubai: The City as Corporation

    OpenAIRE

    Lenell Garland, Laura

    2013-01-01

    Ahmed Kanna’s Dubai: The City as Corporation offers an analysis of what he calls the “family-state” from an angle diametrically opposed to that of journalism and popular scholarship alike. Taking Dubai as a near functional equivalent of the modern nation-state, Kanna goes into the city-state’s well-publicized founding myth, which has been typically characterized by a historical narrative carefully crafted and largely depoliticized by the ruling family. He accomplishes this partly by applying ...

  19. Glaucoma medications.

    Science.gov (United States)

    Chae, Bora; Cakiner-Egilmez, Tulay; Desai, Manishi

    2013-01-01

    Glaucoma is a common eye condition that affects millions of individuals worldwide, making it the second-leading cause of blindness. Because glaucoma is associated with increased IOP level, the primary goal in treatment of glaucoma includes lowering IOP to prevent further progression of the disease. While various surgical interventions exist, medical therapy is currently the first line of treatment. Medical treatment of glaucoma includes topical beta-blockers, alpha-2 agonists, prostaglandins, parasympathomimetics and CAIs. Anti-glaucoma agents help reduce IOP by affecting the production of aqueous humor or increasing the outflow of aqueous through the trabecular or uveoscleral pathway. Choosing an appropriate medical regimen can be challenging and various factors such as efficacy, safety, cost and patient compliance must be considered. First-line treatment is often topical beta-blockers or prostaglandin analogs. However, beta-blocking agents can be associated with systemic side effects and need to be used cautiously in patients with serious concomitant cardiopulmonary disease. Alpha-2 agonists and parasympathomimetics are often considered second- or third-line treatment options but good adjunctive agents. Oral CAIs are often indicated for patients with elevated IOP in an acute setting or for patients resistant to other glaucoma medications and patients who are not good surgical candidates. PMID:23505792

  20. Molecular Genetics in Glaucoma

    OpenAIRE

    Liu, Yutao; Allingham, R. Rand

    2011-01-01

    Glaucoma is a family of diseases whose pathology is defined by the progressive loss of retinal ganglion cells. Clinically, glaucoma presents as a distinctive optic neuropathy with associated visual field loss. Primary open-angle glaucoma (POAG), chronic angle closure glaucoma (ACG), and exfoliation glaucoma (XFG) are the most prevalent forms of glaucoma globally and are the most common causes of glaucoma-related blindness worldwide. A host of genetic and environmental factors contribute to gl...

  1. African Americans and Glaucoma

    Science.gov (United States)

    ... Involved News About Us Donate In This Section African Americans and Glaucoma email Send this article to ... glaucoma is the leading cause of blindness in African Americans. Half of those with glaucoma don't ...

  2. Glaucoma, Open-Angle

    Science.gov (United States)

    ... Prevalent Cases of Glaucoma (in thousands) by Age, Gender, and Race/Ethnicity Because of their longer life ... Prevalent Cases of Glaucoma (in thousands) by Age, Gender, and Race/Ethnicity Projections for Glaucoma (2010-2030- ...

  3. Get Tested for Glaucoma!

    Science.gov (United States)

    ... of this page please turn Javascript on. Feature: Glaucoma Get Tested for Glaucoma! Past Issues / Fall 2009 Table of Contents Taylor ... aoa.org/ When were you finally diagnosed with glaucoma? Not until 1969, after a game of basketball. ...

  4. The drama of Ahmed Yerima : studies in Nigerian theatre

    NARCIS (Netherlands)

    Julius-Adeoye, ‘Rantimi Jays

    2013-01-01

    The Drama of Ahmed Yerima. Studies in Nigerian Theatre gives a detailed development of Nigerian theatre from its ritualistic nature in the 16th Century up to the literary form of the 21st century. It looks at the trajectory movement of the theatre through television to cinema and video film/Nollywoo

  5. Get Tested for Glaucoma!

    Science.gov (United States)

    ... page please turn Javascript on. Feature: Glaucoma Get Tested for Glaucoma! Past Issues / Fall 2009 Table of ... and why it is so important to get tested. To Find Out More MedlinePlus: www.medlineplus.gov ...

  6. Glaucoma in Asian Populations

    Science.gov (United States)

    ... Us Donate In This Section Glaucoma In Asian Populations email Send this article to a friend by ... an even more serious problem as the world population and longevity increases. The other major glaucoma type ...

  7. Daily Life with Glaucoma

    Science.gov (United States)

    ... Size Small Text Medium Text Large Text Contrast Dark on Light Light on Dark Donate Search Menu Donate What is Glaucoma? Care ... Low Vision Resources Medication Guide Resources on the Web » See All Articles Help the Cause Glaucoma affects ...

  8. Coping with Glaucoma

    Medline Plus

    Full Text Available ... told me. Doctor: I told Ben he had glaucoma. I told him we could treat it. But ... me when he did because left untreated his glaucoma might well have cost him his eyesight. In ...

  9. Five Common Glaucoma Tests

    Science.gov (United States)

    ... About Us Donate In This Section Five Common Glaucoma Tests en Español email Send this article to ... year or two after age 35. A Comprehensive Glaucoma Exam To be safe and accurate, five factors ...

  10. Screening for Glaucoma

    Science.gov (United States)

    ... t know which people with early signs of disease will develop serious vision problems or blindness. There are two major ... for advice about glaucoma screening. Glaucoma is a serious disease that affects the health and quality of life ...

  11. Glaucoma Research Foundation

    Science.gov (United States)

    ... and research. Subscribe Browse the Gleams Archive » Glaucoma Research Foundation www.glaucoma.org 251 Post Street, Suite 600 San Francisco , CA 94108 (415) 986-3162 (800) 826-6693 question@ glaucoma.org ... Progress Get Involved News About Us Donate Informacion ...

  12. Genetic bases for glaucoma.

    Science.gov (United States)

    Fuse, Nobuo

    2010-05-01

    Glaucoma is the leading cause of visual impairment and blindness throughout the world. Primary open angle glaucoma (POAG; MIM 137760) is the main type of glaucoma in most populations, and more than 20 genetic loci for POAG have been reported. Only three causative genes have been identified in these loci, viz. myocilin (MYOC), optineurin (OPTN), and WD repeat domain 36 (WDR36). However, mutations in these genes account for only a small percentage of the patients with POAG. Some of these glaucoma cases have a Mendelian inheritance pattern, and a considerable fraction of the cases result from a large number of variants in several genes each contributing small effects. Glaucoma is considered to be a common disease such as diabetes mellitus, coronary disease, Crohn disease, and several( )common cancers. The main technological approaches used to identify the genes associated with glaucoma are the candidate gene approach, linkage analysis, case-control association study, and genome-wide association study. Association studies have found about 27 genes related to POAG, but the glaucoma-causing effects of these genes need to be investigated in more detail. The current trend is to use case-control association studies or genome-wide association studies to map the genes associated with glaucoma. Such studies are expected to greatly advance our understanding of the genetic basis of glaucoma, and to provide information on the effectiveness of glaucoma therapy. This review gives an overview on the genetic aspects of glaucoma. PMID:20431268

  13. Pediatric Glaucoma: Pharmacotherapeutic Options.

    Science.gov (United States)

    Samant, Monica; Medsinge, Anagha; Nischal, Ken K

    2016-06-01

    Childhood glaucoma is a major therapeutic challenge for pediatric ophthalmologists and glaucoma specialists worldwide. Management depends on the etiology and age at presentation. A variety of drugs are available for the control of intraocular pressure in children; however, none of these drugs have been licensed by the regulatory agencies for use in children. Furthermore, evidence gained from randomized controlled trials in the pediatric population is sparse, and little is known regarding the use of newer anti-glaucoma preparations. This evidence-based review aims to discuss the available pharmacotherapeutic options for glaucoma in children. Topical adrenoceptor blockers, topical and systemic carbonic anhydrase inhibitors, prostaglandin (PG) analogs, adrenoceptor agonists, parasympathomimetics, and combined preparations are available for use in children, but usually as an off-label indication. Therefore, it is important to recognize that serious side effects have been reported, even with topical drops, and measures to reduce systemic absorption should be taken. Most drugs have been shown to have comparable ocular hypotensive effects, with the lowest occurrence of systemic side effects with PG analogs. Whereas a newly introduced prostaglandin analog, tafluprost, and some other preservative-free preparations have shown promising results in adult glaucoma patients, no pediatric reports are available as yet. Future studies may describe their role in treating pediatric glaucoma. This review also shares some suggested treatment pathways for primary congenital glaucoma (PCG), juvenile open angle glaucoma (JOAG), developmental glaucoma, aphakic/pseudophakic glaucoma, and uveitic glaucoma. PMID:27093864

  14. Valve Disease

    Science.gov (United States)

    ... Myocarditis Obstructive Sleep Apnea Pericarditis Peripheral Vascular Disease Rheumatic Fever Sick Sinus Syndrome Silent Ischemia Stroke Sudden Cardiac Arrest Vulnerable Plaque Valve Disease | Share Related terms: heart valves, valve insufficiency, valve regurgitation, valve stenosis, valvular ...

  15. Does Marijuana Help Treat Glaucoma?

    Science.gov (United States)

    ... that it does not recommend marijuana or other cannabis products for the treatment of glaucoma . Speak with ... Marijuana for Glaucoma Infographic Leer en Español: La Marihuana y el Glaucoma Find an Ophthalmologist Advanced Search ...

  16. [Late postcontusion secondary glaucoma].

    Science.gov (United States)

    Chiseliţă, D; Vancea, P; Filiman, O; Brănişteanu, D; Bredetean, M; Poiata, I

    1995-01-01

    The investigation of 33 patients with late postcontusional glaucoma subjected to surgery and followed up for 25 +/- 8.24 months has revealed: the interval accident-surgery is shorter in the close-angle combined forms; the essential mechanisms responsible for glaucoma occurrence are: the alteration of trabecular meshwork (for open-angle glaucoma) and pupillary block (for close angle glaucoma); simple cases required antiglaucoma surgery (trabeculectomy, peripheral iridectomy) and the mixed ones required combined (trabeculectomy, lens extraction, lens implant) or sequential surgeries (antiglaucoma surgery, vitrectomy etc); the glaucomatous process was stopped in 83.4% of the open-angle glaucoma cases and progressed in 23.5% of the close-angle glaucoma cases; the functional improvements post antiglaucoma surgery combined with removal of opacities are lessened by the higher frequency of severe per- and post-operative complication. PMID:7654676

  17. Family studies in glaucoma.

    OpenAIRE

    Rosenthal, A R; Perkins, E S

    1985-01-01

    Two groups of patients with a family history of chronic open-angle glaucoma were compared with a normal population of 5919 individuals studied during the Bedford Glaucoma Survey. The mean screening intraocular pressure was significantly raised in both groups with a family history of chronic open-angle glaucoma. The prevalence rate of a raised intraocular pressure was 3.81 times that found in the normal population. This relationship was maintained when age-dependent prevalence rates were evalu...

  18. Corneal thickness in glaucoma.

    Science.gov (United States)

    De Cevallos, E; Dohlman, C H; Reinhart, W J

    1976-02-01

    The central corneal stromal thickness of patients with open angle glaucoma, secondary glaucoma (the majority aphakic), or a history of unilateral acute angle closure glaucoma were measured and compared with the stromal thickness of a group of normal patients. In open angle glaucoma, there was a small but significant increase in the average stromal thickness. This thickness increase was, in all likelihood, due to an abnormal function of the endothelium in this disease since the level of the intraocular pressure did not seem to be a factor. There was no correlation between stromal thickness and duration of the glaucoma or type of anti-glaucomatous medication. Most cases of secondary glaucome, controlled medically or not, had markedly increased corneal thickness, again, most likely, due to endothelial damage rather than to level of intraocular pressure. After an angle closure attack, permanent damage to the cornea was found to be rare. PMID:1247273

  19. Nanotechnology Applications for Glaucoma.

    Science.gov (United States)

    Cetinel, Sibel; Montemagno, Carlo

    2016-01-01

    Glaucoma is the second leading cause of blindness worldwide, and the antiglaucoma treatments currently available suffer from various complications. Nanotechnology-based treatments show a great deal of promise in overcoming these complications and form the basis for next-generation glaucoma treatment strategies, with the help of applications such as controlled release, targeted delivery, increased bioavailability, diffusion limitations, and biocompatibility. Significant progress has been made in nanomedicine in the efficiency of antiglaucoma medications, nanofabrication systems such as microelectromechanical systems that remove the limitations of nanodevices, and tissue regeneration vesicles for developing glaucoma treatments not based on intraocular pressure. With the use of these advanced technologies, the prevention of glaucoma-induced blindness will be possible in the near future. Herein, we reviewed the recent advances in nanotechnology-based treatment strategies for glaucoma. PMID:26693592

  20. [Vascular factors in glaucoma].

    Science.gov (United States)

    Mottet, B; Aptel, F; Geiser, M; Romanet, J P; Chiquet, C

    2015-12-01

    The exact pathophysiology of glaucoma is not fully understood. Understanding of the vascular pathophysiology of glaucoma requires: knowing the techniques for measuring ocular blood flow and characterizing the topography of vascular disease and the mechanisms involved in this neuropathy. A decreased mean ocular perfusion pressure and a loss of vascular autoregulation are implicated in glaucomatous disease. Early decrease in ocular blood flow has been identified in primary open-angle glaucoma and normal pressure glaucoma, contributing to the progression of optic neuropathy. The vascular damage associated with glaucoma is present in various vascular territories within the eye (from the ophthalmic artery to the retina) and is characterized by a decrease in basal blood flow associated with a dysfunction of vasoregulation. PMID:26597554

  1. Assessment of Filtration Bleb and Endplate Positioning Using Magnetic Resonance Imaging in Eyes Implanted with Long-Tube Glaucoma Drainage Devices.

    Directory of Open Access Journals (Sweden)

    Ichiya Sano

    Full Text Available To evaluate ocular fluid filtration and endplate positioning in glaucomatous eyes with long-tube glaucoma drainage devices (GDDs using magnetic resonance imaging (MRI and the effects of various factors on postoperative intraocular pressure (IOP.This observational case series included 27 consecutive glaucomatous eyes (18 men, 7 women; mean age ± standard error, 63.0±2.0 years who underwent GDD implantation (n = 8 Ahmed Glaucoma Valves [AGV] and n = 19 Baerveldt Glaucoma Implants [BGI]. Tubes were inserted into the pars plana in 23 eyes and anterior chamber in 4 eyes. Six months postoperatively, high-resolution orbital images were obtained using 3-Tesla MRI with head-array coils, and the filtering bleb volume, bleb height, and distances between the anterior endplate edge and corneal center or limbus or between the endplate and orbital wall were measured.In MR images obtained by three-dimensional fast imaging employing steady-state acquisition (3D-FIESTA sequences, the shunt endplate was identified as low-intensity signal, and the filtering bleb was identified as high-intensity signals above and below the endplate in all eyes. The 6-month-postoperative IOP level was correlated negatively with bleb volume (r = -0.4510, P = 0.0182 and bleb height (r = -0.3954, P = 0.0412. The postoperative IOP was significantly (P = 0.0026 lower in BGI-implanted eyes (12.2±0.7 mmHg than AGV-implanted eyes (16.7±1.2 mmHg; bleb volume was significantly (P = 0.0093 larger in BGI-implanted eyes (478.8±84.2 mm3 than AGV-implanted eyes (161.1±52.3 mm3. Other parameters did not differ.The presence of intraorbital/periocular accumulation of ocular fluid affects postoperative IOP levels in eyes implanted with long-tube GDDs. Larger filtering blebs after BGI than AGI implantations explain lower postoperative IOP levels achieved with BGI than AGV. The findings will contribute to better understanding of IOP reducing mechanism of long-tube GDDs.

  2. Glaucoma: Screening Can Save Your Sight!

    Science.gov (United States)

    ... of this page please turn Javascript on. Feature: Glaucoma Glaucoma: Screening Can Save Your Sight! Past Issues / Fall 2009 Table of Contents People with glaucoma see the world through a tunnel. Glaucoma is ...

  3. ACUPUNCTURE AND GLAUCOMA

    Institute of Scientific and Technical Information of China (English)

    WANG Ying; HU Shi-xing; BAI Peng

    2006-01-01

    It is to recognize glaucoma in view of Chinese medicine and synthesize the treatments and mechanisms of acupuncture on glaucoma in the paper. It is indicated in the results that acupuncture plays the importance in lowering ocular tension, improving ocular circulation and protecting optic nerve. Additionally,acupuncture inhibits probably the cellular apoptosis of optic ganglion and provides definite actions on psychological factors of glaucoma. Acupuncture cannot replace operation and medicinal therapy in lowing ocular tension, but their coordinated and auxiliary effects are quite clear and definite.

  4. Heart valve surgery

    Science.gov (United States)

    Valve replacement; Valve repair; Heart valve prosthesis; Mechanical valves, Prosthetic valves ... made materials, such as metal (stainless steel or titanium) or ceramic. These valves last the longest, but ...

  5. Glaucoma Treatments and Drugs

    Science.gov (United States)

    ... This procedure is usually used to treat more aggressive or advanced open-angle glaucoma that has not ... to your inbox Sign Up About Research Programs Leadership Partners Accountability Careers Research Research We Fund Alzheimer’s ...

  6. Coping with Glaucoma

    Medline Plus

    Full Text Available ... opthalmologistor optometrist. The exam may include a painless test that measures pressure within the eye and sometimes ... detect glaucoma is with a painless and easy test in which the doctor, using drops to dilate ...

  7. Coping with Glaucoma

    Medline Plus

    Full Text Available ... no way I was prepared for what the doctor told me. Doctor: I told Ben he had glaucoma. I told ... a painless and easy test in which the doctor, using drops to dilate or enlarge the pupil, ...

  8. Coping with Glaucoma

    Medline Plus

    Full Text Available ... comprehensive eye examination performed by a qualified eye care professional such as an opthalmologistor optometrist. The exam ... at-risk individuals -- that's the recommendation of eye care professionals, and that's the way to stop glaucoma ...

  9. Glaucoma in developing countries

    Directory of Open Access Journals (Sweden)

    Ravi Thomas

    2012-01-01

    Full Text Available Objective: To describe the background and strategy required for the prevention of blindness from glaucoma in developing countries. Materials and Methods: Extrapolation of existing data and experience in eye care delivery and teaching models in an unequally developed country (India are used to make recommendations. Results: Parameters like population attributable risk percentage indicate that glaucoma is a public health problem but lack of simple diagnostic techniques and therapeutic interventions are barriers to any effective plan. Case detection rather than population-based screening is the recommended strategy for detection. Population awareness of the disease is low and most patients attending eye clinics do not receive a routine comprehensive eye examination that is required to detect glaucoma (and other potentially blinding eye diseases. Such a routine is not taught or practiced by the majority of training institutions either. Angle closure can be detected clinically and relatively simple interventions (including well performed cataract surgery can prevent blindness from this condition. The strategy for open angle glaucoma should focus on those with established functional loss. Outcomes of this proposed strategy are not yet available. Conclusions: Glaucoma cannot be managed in isolation. The objective should be to detect and manage all potential causes of blindness and prevention of blindness from glaucoma should be integrated into existing programs. The original pyramidal model of eye care delivery incorporates this principle and provides an initial starting point. The routine of comprehensive eye examination in every clinic and its teaching (and use in residency programs is mandatory for the detection and management of potentially preventable blinding pathology from any cause, including glaucoma. Programs for detection of glaucoma should not be initiated unless adequate facilities for diagnosis and surgical intervention are in place and

  10. Post-keratoplasty glaucoma

    OpenAIRE

    S. A. Malozhen; S. V. Trufanov; S. Yu. Petrov

    2015-01-01

    Post-keratoplasty glaucoma (PKG) remains one of the leading causes of blindness due to the loss of optic nerve fibers and irreversible graft opacification. PKG is a challenge due to diagnostic and therapeutic difficulties and recalcitrant course. This paper reviews main pre-operative PKG risk factors such as pre-existing glaucoma, corneal disorders for which keratoplasty is performed, and lens status. Intraoperative errors that caused by ocular hypertension (tight suturing, larger trephine si...

  11. Door valve

    International Nuclear Information System (INIS)

    Object: To reliably block leakage of inner fluid in a door valve by providing a bellows mechanism in a portion where a valve rod penetrates an oil hydraulic cylinder and by sealing opposite side valve seats of the valve body with an oil hydraulic type seal mechanism. Structure: A door valve comprising a valve body movably provided within a valve casing, an oil hydraulic mechanism driving a valve rod directly connected to the valve body, a bellows mechanism provided on a portion where a valve rod penetrates the cylinder of the oil hydraulic mechanism and an oil hydraulic seal mechanism provided on the inner side of an inlet of the valve casing opposing a valve seat of the valve body, thereby isolating such components as the reactor container, casker, relay container and fuel storage tank at the time of replacement of fuel and reliably preventing leakage of liquid metal vapor containing radioactive material. (Kamimura, M.)

  12. Neuroprotection in glaucoma

    Directory of Open Access Journals (Sweden)

    Azadeh Doozandeh

    2016-01-01

    Full Text Available Glaucoma is a degenerative optic neuropathy characterized by retinal ganglion cell (RGC loss and visual field defects. It is known that in some glaucoma patients, death of RGCs continues despite intraocular pressure (IOP reduction. Neuroprotection in the field of glaucoma is defined as any treatment, independent of IOP reduction, which prevents RGC death. Glutamate antagonists, ginkgo biloba extract, neurotrophic factors, antioxidants, calcium channel blockers, brimonidine, glaucoma medications with blood regulatory effect and nitric oxide synthase inhibitors are among compounds with possible neuroprotective activity in preclinical studies. A few agents (such as brimonidine or memantine with neuroprotective effects in experimental studies have advanced to clinical trials; however the results of clinical trials for these agents have not been conclusive. Nevertheless, lack of compelling clinical evidence has not prevented the off-label use of some of these compounds in glaucoma practice. Stem cell transplantation has been reported to halt experimental neurodegenerative disease processes in the absence of cell replacement. It has been hypothesized that transplantation of some types of stem cells activates multiple neuroprotective pathways via secretion of various factors. The advantage of this approach is a prolonged and targeted effect. Important concerns in this field include the secretion of unwanted harmful mediators, graft survival issues and tumorigenesis. Neuroprotection in glaucoma, pharmacologically or by stem cell transplantation, is an interesting subject waiting for broad and multidisciplinary collaborative studies to better clarify its role in clinical practice.

  13. Improving Glaucoma Detection and Management

    Science.gov (United States)

    2015-12-09

    Glaucoma; Glaucoma Suspect; Diabetic Retinopathy; Ocular Hypertension; Cataract; Branch Retinal Vein Occlusion; Branch Retinal Arterial Occlusion; Central Retinal Vein Occlusion; Central Retinal Artery Occlusion; Epi-retinal Membrane; Macular Degeneration; Drusen; Loss of Vision

  14. New Tool to Predict Glaucoma

    Science.gov (United States)

    ... Size Small Text Medium Text Large Text Contrast Dark on Light Light on Dark Donate Search Menu Donate What is Glaucoma? Care ... Low Vision Resources Medication Guide Resources on the Web » See All Articles Help the Cause Glaucoma affects ...

  15. Does Your Child Have Glaucoma?

    Science.gov (United States)

    ... Donate In This Section Does Your Child Have Glaucoma? email Send this article to a friend by ... a pediatric ophthalmologist. Signs and Symptoms of Childhood Glaucoma What to watch for in children under the ...

  16. Post-keratoplasty glaucoma

    Directory of Open Access Journals (Sweden)

    S. A. Malozhen

    2015-10-01

    Full Text Available Post-keratoplasty glaucoma (PKG remains one of the leading causes of blindness due to the loss of optic nerve fibers and irreversible graft opacification. PKG is a challenge due to diagnostic and therapeutic difficulties and recalcitrant course. This paper reviews main pre-operative PKG risk factors such as pre-existing glaucoma, corneal disorders for which keratoplasty is performed, and lens status. Intraoperative errors that caused by ocular hypertension (tight suturing, larger trephine sizes, long bites of individual sutures, increased peripheral corneal thickness and graft-host disparity are evaluated. Peripheral anterior synechiae, steroid use, and tonometry errors after deep anterior lamellar keraplasty are amongst post-operative causes of PKG. Partial transparency optical media, high post-operative astigmatism and graft edema make standard tonometry unreliable. Various tonometers and measurement reliability after keratoplasty are discussed. Currently, multiple treatment options including medications, laser and filtering surgery, glaucoma drainage devices and cyclodestructive procedures are available. In most cases of PKG, medications are initially prescribed. Evolution of approaches to PKG treatment as well as current therapy schedules, their advantages and ophthalmic complications are discussed. In cases non-responsive to medications, laser trabeculoplasty is performed. If laser procedures cannot be performed of their hypotensive effect is insufficient, glaucoma surgery is advised. A number of specialists prefer trabeculectomy with intra- or post-operative cytostatic adjunct. Glaucoma surgery with various drainage device implantation prevails. Ineffective surgery can be enhanced with transscleral laser cyclophotocoagulation.

  17. Infantile-onset glaucoma and anterior megalophthalmos in osteogenesis imperfecta.

    Science.gov (United States)

    Bohnsack, Brenda L

    2016-04-01

    Osteogenesis imperfecta (OI) is an inherited condition in which defects in type 1 collagen cause abnormalities in many tissues and organs, including bone, teeth, heart valves, and eyes. We describe a 6-month-old boy with OI who presented with anterior megalophthalmos of the right eye and infantile-onset glaucoma of the left eye. To our knowledge, this is the first reported case of these types of congenital eye anomalies in an infant with OI. PMID:26994503

  18. Modern Technologies of Open-Angle Glaucoma Surgery

    Directory of Open Access Journals (Sweden)

    Svetozarskiy S.N.

    2014-03-01

    Full Text Available Currently, glaucoma surgery has become a major technique. Surgery is a method of choice in open-angle glaucoma, especially in those cases when conservative and laser treatments have no effect, as well as if glaucoma is inaccessible or a patient has low treatment compliance. In this review the authors give the information about the development of main glaucoma surgery directions, such as removal of pupillary block, the anterior chamber fistulization, the reduction of intraocular fluid production. Drainage surgery, its history and modern technical devices have been characterized in detail. The design of drainage devices has been improved towards their size reduction, extension of filtration area and the development of valve mechanisms. Indications for their implementation in open-angle glaucoma treatment, and the factors contributing to a successful treatment have been discussed. There have described early and late complications of microdrainage and paid particular attention to obliteration of developed outflow pathways, being the main problem as they reduce the effect of filtering and draining operations. The authors have presented a number of advanced micro-invasive technologies, both used in clinical practice (Ex-PRESS™ mini-shunt, Trabectome™, iStent, canaloplasty and viscocanalostomy, and those being under clinical study — SOLX Gold Micro-Shunt, CyPass, Hydrus™ Microstent a canalicular scaffold, AqueSys Microfistula Implant. There has been presented the information on design and technology of these devices with their detailed classification based on the differences in their mechanism of action, operative approach type and material used.

  19. Intraocular lens dislocation and tube shunt in the posterior chamber: a case report

    OpenAIRE

    Moreno-Montañés, Javier; Velázquez-Villoria, Alvaro; Sabater, Alfonso L.; Salinas-Alamán, Angel

    2015-01-01

    Background To describe management of a case of intraocular lens (IOL) and capsular bag (CB) dislocation in an eye with an Ahmed glaucoma valve in the posterior chamber. Case presentation A 75-year-old pseudophakic man with open-angle glaucoma and diabetic retinopathy developed neovascular glaucoma. After two intravitreous injections of bevacizumab and panretinal photocoagulation were administered, the new vessels regressed. However, goniosynechiae were observed over 360° of the angle. An Ahme...

  20. Pediatric glaucoma: current perspectives

    Directory of Open Access Journals (Sweden)

    Marchini G

    2014-05-01

    Full Text Available Giorgio Marchini, Marco Toscani, Francesca Chemello Eye Clinic, Department of Neurological and Movement Sciences, University of Verona, Verona, Italy Abstract: “Childhood glaucoma” is a heterogeneous group of severe pediatric conditions often associated with significant visual loss and characterized by elevated intraocular pressure (IOP and optic-disk cupping. Successful IOP control is crucial but challenging and most often achieved surgically, with medical therapy playing a supportive role. There are many classifications of childhood glaucoma, but they can simply be divided into primary, in which a developmental abnormality of the anterior chamber angle only exists, and secondary, in which aqueous outflow is reduced due to independent mechanisms that secondarily impair the function of the filtration angle. The worldwide prevalence of childhood blindness ranges from 0.03% in high-income countries to 0.12% in undeveloped countries. The majority of cases do not have an identified genetic mutation and, where the mutation is known, the genes often account for only a small proportion of cases. Several pathogenetic mechanisms are known to contribute to the development of childhood glaucoma. Whatever the cause, it results in a reduced aqueous outflow at the level of the trabecular meshwork. Age of onset and magnitude of the elevated IOP largely determine the clinical manifestation the high variability of clinical manifestations. Glaucoma from any cause in a neonate and infant is characterized by the classic triad of epiphora, photophobia, and blepharospasm, and could be associated with eye enlargement (buphthalmos and Haab striae. The eye examination, usually performed under general anesthesia, includes: tonometry, anterior-segment examination, gonioscopy, corneal diameter and axial length measurement, dilated fundoscopy with optic-nerve-head evaluation. Medical therapy, considering the high frequency of side effects, is generally used as

  1. [Contrast sensitivity in glaucoma].

    Science.gov (United States)

    Bartos, D

    1989-05-01

    Author reports on results of the contrast sensitivity examinations using the Cambridge low-contrast lattice test supplied by Clement Clarke International LTD, in patients with open-angle glaucoma and ocular hypertension. In glaucoma patients there was observed statistically significant decrease of the contrast sensitivity. In patients with ocular hypertension decrease of the contrast sensitivity was in patients affected by corresponding changes of the visual field and of the optical disc. The main advantages of the Cambridge low-contrast lattice test were simplicity, rapidity and precision of its performance. PMID:2743444

  2. Neuroprotection in glaucoma.

    Directory of Open Access Journals (Sweden)

    Kaushik S

    2003-01-01

    Full Text Available Currently, glaucoma is recognised as an optic neuropathy. Selective death of retinal ganglion cells (RGC is the hallmark of glaucoma, which is also associated with structural changes in the optic nerve head. The process of RGC death is thought to be biphasic: a primary injury responsible for initiation of damage that is followed by a slower secondary degeneration related to noxious environment surrounding the degenerating cells. For example, retinal ishaemia may establish a cascade of changes that ultimately result in cell death: hypoxia leads to excitotoxic levels of glutamate, which cause a rise in intra-cellular calcium, which in turn, leads to neuronal death due to apoptosis or necrosis. Neuroprotection is a process that attempts to preserve the cells that were spared during the initial insult, but are still vulnerable to damage. Although not yet available, a neuroprotective agent would be of great use in arresting the progression of glaucoma. There is evidence that neuroprotection can be achieved both pharmacologically and immunologically. Pharmacological intervention aims at neutralising some of the effects of the nerve-derived toxic factors, thereby increasing the ability of the spared neurons to cope with stressful conditions. On the other hand, immunological interventions boost the body′s own repair mechanisms for counteracting the toxic effects of various chemicals generated during the cascade. This review, based on a literature search using MEDLINE, focuses on diverse cellular events associated with glaucomatous neurodegeneration, and discusses some pharmacological agents believed to have a neuroprotective role in glaucoma.

  3. Glaucoma: Symptoms, Diagnosis & Treatment

    Science.gov (United States)

    ... inside this specially designed contact lens. In laboratory experiments, the lens, which can also correct vision, releases ... eye rapidly and inconsistently. During testing in an animal model, the new ... multi-institution research team has found that glaucoma appears to result ...

  4. OCT Imaging in Glaucoma

    Science.gov (United States)

    Nevins, Jessica E.; Wollstein, Gadi; Schuman, Joel S.

    The precise micron scale quantification of ocular structures provided by OCT turn this technology to be a valuable tool in clinical evaluation of glaucoma patients. This chapter describes the clinical utility of OCT from choosing the scan pattern and scan location to the interpretation of the test outcome.

  5. Glaucoma: Symptoms, Diagnosis, Treatment and Latest Research

    Science.gov (United States)

    ... of this page please turn Javascript on. Feature: Glaucoma Glaucoma: Symptoms, Diagnosis, Treatment and Latest Research Past Issues / Fall 2009 Table of Contents Symptoms and Diagnosis Glaucoma can develop in one or both eyes. Often ...

  6. Check valve

    International Nuclear Information System (INIS)

    A check valve for use in a GDCS of a nuclear reactor and having a motor driven disk including a rotatable armature for rotating the check valve disk over its entire range of motion is described. In one embodiment, the check valve includes a valve body having a coolant flow channel extending therethrough. The coolant flow channel includes an inlet end and an outlet end. A valve body seat is located on an inner surface of the valve body. The check valve further includes a disk assembly, sometimes referred to as the motor driven disc, having a counterweight and a disk shaped valve. The disk valve includes a disk base having a seat for seating with the valve body seat. The disk assembly further includes a first hinge pin member which extends at least partially through the disk assembly and is engaged to the disk. The disk valve is rotatable relative to the first hinge pin member. The check valve also includes a motor having a stator frame with a stator bore therein. An armature is rotatably positioned within the stator bore and the armature is coupled to the disk valve to cause the disk valve to rotate about its full range of motion. 5 figs

  7. Normal-tension glaucoma (Low-tension glaucoma)

    OpenAIRE

    Anderson Douglas

    2011-01-01

    Glaucoma is now considered an abnormal physiology in the optic nerve head that interacts with the level of intraocular pressure (IOP), with the degree and rate of damage depending on the IOP and presumably the degree of abnormal physiology. Diagnosis of normal-tension glaucoma (NTG), defined as glaucoma without a clearly abnormal IOP, depends on recognizing symptoms and signs associated with optic nerve vulnerability, in addition to absence of other explanations for disc abnormality and visua...

  8. Selection of lubricant material for the roller chains of the AHM grapple drive system for the CRBRP

    International Nuclear Information System (INIS)

    Properties of Anderol 732 lubricating grease are evaluated to meet the design requirements for the Clinch River Breeder Reactor Plant (CRBRP) auxiliary handling machine (AHM) chain lubrication. Based on the evaluation made in this report, the material is recommended as a lubricant for the specified application. The material is to be applied by the chain manufacturer prior to installation in the AHM. 1 tab

  9. Glaucoma and Corneal Transplant Procedures

    Directory of Open Access Journals (Sweden)

    Ammar M. Al-Mahmood

    2012-01-01

    Full Text Available Glaucoma after corneal transplantation is a leading cause of ocular morbidity after penetrating keratoplasty. The incidence reported is highly variable and a number of etiologic factors have been identified. A number of treatment options are available; surgical intervention for IOP control is associated with a high incidence of graft failure. IOP elevation is less frequently seen following deep anterior lamellar keratoplasty. Descemet's striping-automated endothelial keratoplasty is also associated with postprocedure intraocular pressure elevation and secondary glaucoma and presents unique surgical challenges in patients with preexisting glaucoma surgeries. Glaucoma exists in up to three-quarters of patients who undergo keratoprosthesis surgery and the management if often challenging. The aim of this paper is to highlight the incidence, etiology, and management of glaucoma following different corneal transplant procedures. It also focuses on the challenges in the diagnosis of glaucoma and intraocular pressure monitoring in this group of patients.

  10. Glaucoma in patients with uveitis.

    OpenAIRE

    Panek, W C; Holland, G N; Lee, D A; Christensen, R E

    1990-01-01

    The records of 100 patients (161 eyes) with uveitis were reviewed retrospectively to determine the prevalence of increased intraocular pressure, the forms of uveitis most commonly associated with glaucoma, and the forms that require specific glaucoma therapy. Secondary glaucoma was present in 23 patients (31 eyes): three of 24 patients with acute uveitis (three eyes, 12% of acute uveitis patients) and 20 of 76 patients with chronic uveitis (28 eyes, 26% of chronic uveitis patients). Eighteen ...

  11. The management of complicated glaucoma

    Directory of Open Access Journals (Sweden)

    Clement C

    2011-12-01

    Full Text Available Complicated glaucomas present considerable diagnostic and management challenges. Response to treatment can be unpredictable or reduced compared with other glaucomas. However, target intraocular pressure and preservation of vision may be achieved with selected medical, laser and surgical treatment. The evidence for such treatment is expanding and consequently affords clinicians a better understanding of established and novel techniques. Herein we review the mechanisms involved in the development of complicated glaucoma and the current evidence supporting its management.

  12. Neuroprotective therapies for glaucoma

    Directory of Open Access Journals (Sweden)

    Song W

    2015-03-01

    Full Text Available Wei Song, Ping Huang, Chun Zhang Department of Ophthalmology, Peking University Third Hospital, Beijing, People’s Republic of China Abstract: Glaucoma is the second leading cause for blindness worldwide. It is mainly caused by glaucomatous optic neuropathy (GON characterized by retinal ganglion cell loss, which leads to visual field defect and blindness. Up to now, the main purpose of antiglaucomatous therapies has been to lower intraocular pressure (IOP through surgeries and medications. However, it has been found that progressive GON is still present in some patients with effective IOP decrease. Therefore, risk factors other than IOP elevation, like neurotrophin deprivation and excitotoxicity, contribute to progressive GON. Novel approaches of neuroprotection may be more effective for preserving the function of the optic nerve. Keywords: glaucoma, glaucomatous optic neuropathy, retinal ganglion cells, neuro­protection

  13. A study of the Sa-Ahm Five Element acupuncture theory.

    Science.gov (United States)

    Ahn, Chang-Beohm; Jang, Kyung-Jun; Yoon, Hyun-Min; Kim, Cheol-Hong; Min, Young-Kwang; Song, Chun-Ho; Lee, Jang-Cheon

    2009-12-01

    This study is a review of the theoretical basis of Sa-Ahm Five Element acupuncture devised about 360 years ago. A total of 21 books and papers ranging from the ancient Huang Di Nei Jing to modern biomedical acupuncture for pain management were researched in relation to the Five Shu points. Gao-Wu, in the Chinese Ming Dynasty, used the Five Shu points for the first time based on the creation cycle as the tonification and sedation treatment, termed the "tonification and sedation treatment of self meridian". Since then, and for no particular reason, this method has been rarely used until Sa-Ahm's new doctrine, which includes the concept of the destruction cycle, was asserted. Sa-Ahm Five Element acupuncture is a method in which the Five Shu points are used from the viewpoints of the simultaneous tonification and sedation methods that are based on the promotion and control cycles. Although it is currently the most utilized method in accordance with the practitioner's points, this method is in need of designated guidelines by which Sa-Ahm acupuncture can be practiced effectively. PMID:20633508

  14. Ceratoplastia penetrante e glaucoma Penetrating keratoplasty and glaucoma

    Directory of Open Access Journals (Sweden)

    Márcio Eulálio Barreto Soares

    2007-08-01

    Full Text Available O objetivo deste artigo é discutir os conhecimentos atuais sobre a abordagem clínica e terapêutica da ceratoplastia penetrante e do glaucoma a ela associado.The aim of this article is to make a review about glaucoma associated with penetrating keratoplasty, describing since its incidence and risk factors until the different options for treatment.

  15. Depressurization valve

    International Nuclear Information System (INIS)

    A depressurization valve for use in relieving completely the pressure in a simplified boiling water reactor is disclosed. The normally closed and sealed valve is provided with a valve body defining a conduit from an outlet of a manifold from the reactor through a valve seat. A closing valve disk is configured for fitting to the valve seat to normally close the valve. The seat below the disk is provided with a radially extending annulus extending a short distance into the aperture defined by the seat. The disk is correspondingly provided with a longitudinally extending annulus that extends downwardly through the aperture defined by the seat towards the high pressure side of the valve body. A ring shaped membrane is endlessly welded to the seat annulus and to the disk annulus. The membrane is conformed over the confronted surface of the seat and disk in a C-sectioned configuration to seal the depressurization valve against the possibility of weeping. The disk is held to the closed position by an elongate stem extending away from the high pressure side of the valve body. The stem has a flange configured integrally to the stem for bias by two springs. The first spring acts from a portion of the housing overlying the disk on the stem flange adjacent the disk. This spring urges the stem and attached disk away from the seat and thus will cause the valve to open at any pressure. A second spring-preferably of the Belleville variety-acts on a latch plate surrounding and freely moving relative to the end of the stem. This second spring overcomes the bias of the first spring and any pressure acting upon the disk. This Belleville spring maintains through its spring force the valve in the closed position. At the same time, the latch plate with its freedom of movement relative to the stem allows the stem to thermally expand during valve temperature excursion

  16. Glaucoma in atomic bomb survivors.

    Science.gov (United States)

    Kiuchi, Yoshiaki; Yokoyama, Tomoko; Takamatsu, Michiya; Tsuiki, Eiko; Uematsu, Masafumi; Kinoshita, Hirofumi; Kumagami, Takeshi; Kitaoka, Takashi; Minamoto, Atsushi; Neriishi, Kazuo; Nakashima, Eiji; Khattree, Ravindra; Hida, Ayumi; Fujiwara, Saeko; Akahoshi, Masazumi

    2013-10-01

    Radiation has been associated with increases in noncancerous diseases. An effect of low-dose radiation on the prevalence of clinically detected glaucoma has not been previously reported. We therefore investigated the prevalence of glaucoma in A-bomb survivors and its possible association with radiation dose. A total of 1,589 people who participated in the clinical examination program for A-bomb survivors at the Radiation Effects Research Foundation (RERF) between October 2006 and September 2008 and who had reconstructed radiation doses, were recruited into this cross-sectional screening study. The prevalence of glaucoma and its dose-response relationship to A-bomb radiation were measured. Each subject underwent an initial screening consisting of an interview and ophthalmological examination. Questionable cases with any indication of ocular disease, including glaucoma, were referred to local hospitals for more comprehensive evaluation. A diagnosis of glaucoma was made based on specific optic disc appearance, perimetric results and other ocular findings. Of 1,589 eligible people, we detected 284 (17.9%) cases of glaucoma overall, including 36 (2.3%) cases of primary open-angle glaucoma with intraocular pressure levels greater than 21 mmHg, 226 (14.2%) cases of normal-tension glaucoma and 25 (1.6%) cases of primary angle-closure glaucoma. Seven glaucoma risk factors were examined as potential confounders but only two needed to be included in the final model. Binary regression using a generalized estimating equation method, with adjustment for gender, age, city, cataract surgery or diabetes mellitus, revealed an odds ratio at 1 Gy of 1.31 (95% confidence interval 1.11-1.53, P = 0.001) in the case of normal-tension glaucoma, but no association for other types of glaucoma. The prevalence of normal-tension glaucoma may increase with A-bomb radiation dose, but uncertainties associated with nonparticipation (59% participation) suggest caution in the interpretation of these

  17. Glaucoma: role of neuroprotective agents

    Directory of Open Access Journals (Sweden)

    Achyut N. Pandey

    2014-10-01

    Full Text Available Glaucoma is an optic neuropathy, considered as the second leading cause of blindness worldwide. Glaucoma is characterized by selective death of retinal ganglion cells (RGC and a progressive loss of vision. Elevated intraocular pressure (IOP is one of the most important risk factors for developing glaucoma and hence we mainly focus on lowering IOP to arrest the progression of glaucoma. However, many patients continue to demonstrate a clinically downhill course despite the control of initially raised IOP. In fact, some patients develop what is called normal tension glaucoma, not associated to an increased IOP. This emphasizes that several pressure-independent mechanisms are responsible for the development and progression of glaucomatous neuropathy and that high IOP and vascular insufficiency in the optic nerve head are only risk factors for the development of glaucoma, and are not the only target for the treatment of glaucoma. The reason is that the process of RGC death is thought to be biphasic, and the primary injury is followed by a slower secondary degeneration related to a noxious environment surrounding the apoptotic cells. This environment is characterized by changes in the extra-cellular ionic concentrations, increased amounts of free radicals, neurotrophins (NT depletion and increased glutamate-induced excitotoxicity due to high extra-cellular glutamate levels, which binds to N-methyl-D-aspartate (NMDA receptors leading to an abnormally high intracellular Ca2+ concentration. Neuroprotection is a process that attempts to preserve the remaining cells that are still vulnerable to damage, and the main aim of neuroprotective therapy is to employ pharmacologic or other means to attenuate the hostility of the environment surrounding the degenerating cells, or to supply the cells with the tools to deal with this aggression, providing resilience to the insult. Several agents have been reported neuroprotective in glaucoma, both in clinical assays

  18. Advanced glaucoma: Management pearls

    Directory of Open Access Journals (Sweden)

    Girum W Gessesse

    2013-01-01

    Full Text Available A significant proportion of glaucoma patients present late, particularly in the developing world, and unfortunately, in an advanced stage of the disease. They are at imminent danger of losing remaining vision, and may also be afflicted with various socioeconomic and health challenges. The encounter with such a patient is typically characterized by anxiety/fear and sometimes hopelessness from the patient′s perspective. The physician may also feel that they are in a difficult position managing the patient′s disease. When dealing with such cases, we suggest a holistic, individualized approach taking into account the ′biopsychosociospiritual′ (BPSS profile of each patient. The BPSS model takes into account relevant ocular as well as systemic biology (factors such as the mechanism of glaucoma, level of intraocular pressure [IOP], rate of progression, life expectancy, general health, psychological considerations (e.g., fear, depression, socio-economic factors and spiritual/cultural values and beliefs before being able to decide with the patient and their care partner(s what treatment goals should be and how they can best be approached. Treatment for advanced glaucoma can be highly effective, and patients and their care partners should be informed that aggressive IOP lowering to the low teens or even single digits offers the best chance of protecting remaining vision. This can be achieved safely and effectively in most cases with trabeculectomy (including an antimetabolite, and in some cases with medical and/or laser therapy. Vision rehabilitation and psychosocial support should also be considered in order to optimize remaining vision, replace fear with hope as appropriate, and thus improve the overall quality of life.

  19. Provider Education about Glaucoma and Glaucoma Medications during Videotaped Medical Visits

    OpenAIRE

    Betsy Sleath; Blalock, Susan J; Carpenter, Delesha M.; Kelly W. Muir; Robyn Sayner; Scott Lawrence; Giangiacomo, Annette L.; Mary Elizabeth Hartnett; Gail Tudor; Jason Goldsmith; Robin, Alan L.

    2014-01-01

    Objective. The purpose of this study was to examine how patient, physician, and situational factors are associated with the extent to which providers educate patients about glaucoma and glaucoma medications, and which patient and provider characteristics are associated with whether providers educate patients about glaucoma and glaucoma medications. Methods. Patients with glaucoma who were newly prescribed or on glaucoma medications were recruited and a cross-sectional study was conducted at s...

  20. Watch Out for Glaucoma | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... of this page please turn JavaScript on. Feature: Glaucoma Watch Out for Glaucoma Past Issues / Spring 2015 Table of Contents A ... used to check eye pressure for signs of glaucoma. Photo courtesy of NEI Glaucoma is a group ...

  1. Glaucoma after Congenital Cataract Surgery

    Directory of Open Access Journals (Sweden)

    Mahmoodreza Panahi Bazaz

    2014-05-01

    Full Text Available Purpose: To determine the incidence and risk factors associated with glaucoma following congenital cataract surgery (CCS in children under age of 15 Methods: This prospective cohort (since 2006 consisted of children less than 15 years of age who underwent cataract surgery with or without intraocular lens (IOL implantation. The role of the following factors on the development of glaucoma after CCS including age at surgery, gender, laterality of the cataract, IOL implantation, congenital ocular anomalies, intra- and postoperative complications, length of follow-up, central corneal thickness (CCT as well as the effect of the age of onset, time to development of glaucoma, and response to treatment were evaluated. Results: Overall, 161 eyes of 96 patients were included in this study of which 28 eyes developed glaucoma. Incidence of glaucoma was 17.4%. Mean±SD age at surgery was 9.3±6.9 (range, 1-24 months in glaucomatous and 40.4±41.1 (range, 1 m-13.6 year months in non-glaucomatous group (p<0.001. All glaucoma patients had the operation under two years of age. In group 1, 9 (60% and in group 2, 24 (30% patients were female (p=0.001. In group 1, 17 eyes (60.7% and in the group 2, 41 eyes (30.8% were aphakic (p=0.001. Mean time to diagnosis of glaucoma was 111.2 days (range 30-1200 days. Mean follow-up time was 3.1 years (range, 1-6 years. In 22 (78.6% eyes glaucoma was diagnosed within six months after surgery. Glaucoma was controlled with medications in 23 eyes (82% and with surgery in five eyes. Conclusion: In this study the incidence of glaucoma after CCS was 17.4% over a follow-up period of six years. Younger age at the time of lensectomy increases the risk of secondary glaucoma. IOL implantation may protect against glaucoma. Female gender was affected more than male.

  2. Evaluation of a glaucoma patient

    Directory of Open Access Journals (Sweden)

    Thomas Ravi

    2011-12-01

    Full Text Available The diagnosis of glaucoma is usually made clinically and requires a comprehensive eye examination, including slit lamp, applanation tonometry, gonioscopy and dilated stereoscopic evaluation of the optic disc and retina. Automated perimetry is obtained if glaucoma is suspected. This establishes the presence of functional damage and provides a baseline for follow-up. Imaging techniques are not essential for the diagnosis but may have a role to play in the follow-up. We recommend a comprehensive eye examination for every clinic patient with the objective of detecting all potentially sight-threatening diseases, including glaucoma.

  3. Zakajev: Tšetšeenia on Euroopa, mitte Vene siseasi / Ahmed Zakajev ; interv. Kadri Liik

    Index Scriptorium Estoniae

    Zakajev, Ahmed

    2003-01-01

    Tšetšeenia presidendi Aslan Mashadovi esindaja Ahmed Zakajev vastab küsimustele, mis puudutavad tema kohtuasja, Vene-Tšetšeenia konflikti, tshetsheenide tungimist Dagestani 1999. aastal. Tema hinnangul saab püsiva rahu tuua vaid Tšetšeenia kuulutamine rahvusvaheliseks protektoraadiks. Vt. samas: Analüütik: aitaks rahvusvaheline sekkumine. Tšetšeenia sõdade kronoloogia

  4. Altered aquaporin expression in glaucoma eyes

    DEFF Research Database (Denmark)

    Tran, Thuy Linh; Bek, Toke; la Cour, Morten;

    2014-01-01

    , AQP7 and AQP9 in human glaucoma eyes compared with normal eyes. Nine glaucoma eyes were examined. Of these, three eyes were diagnosed with primary open angle glaucoma; three eyes had neovascular glaucoma; and three eyes had chronic angle-closure glaucoma. Six eyes with normal intraocular pressure and...... intensity (p = 0.037). No difference in AQP1, AQP4 and AQP9 expression was found in the optic nerve fibres. This study is the first investigating AQPs in human glaucoma eyes. We found a reduced expression of AQP9 in the retinal ganglion cells of glaucoma eyes. Glaucoma also induced increased AQP7 expression......Aquaporins (AQP) are channels in the cell membrane that mainly facilitate a passive transport of water. In the eye, AQPs are expressed in the ciliary body and retina and may contribute to the pathogenesis of glaucoma and optic neuropathy. We investigated the expression of AQP1, AQP3, AQP4, AQP5...

  5. Computational analysis of flow field around Ahmed car model passing underneath a flyover

    Science.gov (United States)

    Musa, Md Nor; Osman, Kahar; Hamat, Ab Malik A.

    2012-06-01

    A flow structure around a ground vehicle has been studied by many researchers using numerous methods, either computational or experimental. However, no analysis of flow field generated by a car passing under a flyover has been carried out. One of the famous simplified models of a car is the Ahmed body that has been established to investigate the influence of the flow structure on the drag. In this paper, we investigate a flow field around Ahmed body of a single cruising condition as the vehicle passes under a flyover, using a computational method with RANS equation. The main objective of this paper is to evaluate the turbulence kinetic energy and velocity magnitude developed within the wall boundary created by the flyover, to the air flow field that is generated by the Ahmed reference car. It was observed that the simulated airflow passes the vehicle was bounded by the wall of the flyover and consequently changes the pattern of the flow field. Understanding the characteristic of this flow field under a flyover is essential if one wants to maximize the recovery of the dissipated energy which, for example, can be used to power a small vertical-axis wind turbine to produce and store electrical energy for lighting under the flyover.

  6. [Current trends in neovascular glaucoma treatment].

    Science.gov (United States)

    Vancea, P P; Abu-Taleb, A

    2005-01-01

    Neovascular glaucoma is divided in three clinical stages: rubeosis iridis, secondary open-angle glaucoma, and synechia of the angle-closure glaucoma. 36% of neovascular glaucomas occurs after central retinal vein occlusion, 32% after diabetic proliferative retinopathy, and 13% occurs after carotid artery obstructive. The key of success in the treatment of neovascular glaucoma is the early and rightly diagnosis, the treatment is aimed mainly at relieving pain, as the prognosis for maintaining visual function is extremely poor. The most important surgical procedures are trabeculectomy, artificial drainage shunts and cyclo-distraction by trans-scleral diode laser. This essay presents a synthesis of modern principle data concerning neovascular glaucoma. PMID:16607783

  7. Cerebrospinal Fluid Pressure and Glaucoma

    OpenAIRE

    Jonas, Jost B; Ningli Wang

    2013-01-01

    Eyes with normal-pressure glaucoma and those with high-pressure glaucoma can show a similar optic nerve head appearance, while eyes with vascular optic neuropathies show a markedly different optic disc appearance. Factors in addition to intraocular pressure (IOP) may thus play a role in the pathogenesis of glaucomatous optic neuropathy. Clinical and experimental studies showed that (1) physiologic associations between cerebrospinal fluid (CSF) pressure, systemic arterial blood pressure, IOP a...

  8. Dry Eyes and Glaucoma: Double Trouble

    Science.gov (United States)

    ... Size Small Text Medium Text Large Text Contrast Dark on Light Light on Dark Donate Search Menu Donate What is Glaucoma? Care ... Low Vision Resources Medication Guide Resources on the Web » See All Articles Help the Cause Glaucoma affects ...

  9. Association Between Diabetes Mellitus And Glaucoma

    OpenAIRE

    Oshitari T

    2014-01-01

    It has not been determined definitively whether there is a significant association between diabetes mellitus (DM) and glaucoma. Some population-based studies have shown a positive association between diabetes and glaucoma, and others have shown negative association between diabetes and glaucoma. However in many studies that showed a lack of a significant association between diabetes and glaucoma, the diagnosis of DM was made by self-presentation.

  10. Provider Education about Glaucoma and Glaucoma Medications during Videotaped Medical Visits

    Directory of Open Access Journals (Sweden)

    Betsy Sleath

    2014-01-01

    Full Text Available Objective. The purpose of this study was to examine how patient, physician, and situational factors are associated with the extent to which providers educate patients about glaucoma and glaucoma medications, and which patient and provider characteristics are associated with whether providers educate patients about glaucoma and glaucoma medications. Methods. Patients with glaucoma who were newly prescribed or on glaucoma medications were recruited and a cross-sectional study was conducted at six ophthalmology clinics. Patients’ visits were videotape recorded and patients were interviewed after visits. Generalized estimating equations were used to analyze the data. Results. Two hundred and seventy-nine patients participated. Providers were significantly more likely to educate patients about glaucoma and glaucoma medications if they were newly prescribed glaucoma medications. Providers were significantly less likely to educate African American patients about glaucoma. Providers were significantly less likely to educate patients of lower health literacy about glaucoma medications. Conclusion. Eye care providers did not always educate patients about glaucoma or glaucoma medications. Practice Implications. Providers should consider educating more patients about what glaucoma is and how it is treated so that glaucoma patients can better understand their disease. Even if a patient has already been educated once, it is important to reinforce what has been taught before.

  11. View How Glaucoma May Affect Vision

    Science.gov (United States)

    ... inbox. Sign up View How Glaucoma May Affect Vision Normal Vision This is an example of normal vision. This is also an example of how someone ... gradual and often imperceptible failing of side (peripheral) vision. Intermediate Glaucoma As glaucoma progresses, the center of ...

  12. Chinical Analysis of Steroid Glaucoma

    Institute of Scientific and Technical Information of China (English)

    LingxunKong; ChengZhang

    1995-01-01

    Purpose:The authors accumulated 15cases(26eyes)of steroid glaucoma due to topical administration of dexamethasone or prednisolone.Methods:From1970to 1990,26eyesin 15cases were observed(Bilateral11cas-es,unilateral4cases)including 12right eyes and 14left eyes.10cases were male and 5cases female with age ranging from14to52years averaging 28years.25eyes had the manifestation of chronic open angle glaucoma in the clinical coures,and 1eye simulated an acute glaucoma attack.Results:All patents had taken antiglaucoma medication before coming to our ohs-pital,but theIOPwas over6.7kPa in9eyes.TheC/Dration was equal to or over0.6in 9cases(16eyes).and the values were inconsistent between both eyes in 55%of the patients.Treatment for glaucoma was immediate discontinuation of the steroids with antiglaucoma medication if necessary.Three eyes received filter-ing operations and 2eyes had the removal of subconjunctival residual steroid.Normal IOPwas restored in monyths up to a year.Conclusion:Dexamethasone of prednisolone were the easiest to induce steroid glaucoma when the patients had long0term use of steroid eyedrops.

  13. Consumer Perceptions of Brand Trust Online of Clothing in Karachi: A case study of Gul Ahmed

    OpenAIRE

    Amna Javed; Shahzaib Khan

    2014-01-01

    Online purchase, in the clothing industry of Pakistan, is on a historical high. There are various factors that affect the brand trust of online consumers. This research is aimed to find the correlation between security and privacy of personal information, name of the brand, word-of-mouth, prior online experience and information quality on the one hand and the online brand trust of consumers on the other. The study is conducted in relation to a single brand, named Gul Ahmed. The sample for thi...

  14. Consumer perception of brand trust online of clothing in Karachi: A case study of Gul Ahmed.

    OpenAIRE

    Amna Javed; Shazaib Khan

    2014-01-01

    Online purchase, in the clothing industry of Pakistan, is on a historical high. There are various factors that affect the brand trust of online consumers. This research is aimed to find the correlation between security and privacy of personal information, name of the brand, word-of-mouth, prior online experience and information quality on the one hand and the online brand trust of consumers on the other. The study is conducted in relation to a single brand, named Gul Ahmed. The sample for thi...

  15. [Valve-in-valve with Portico valve for a degenerative bioprosthetic surgical valve (Biocor)].

    Science.gov (United States)

    Latini, Roberto Adriano; Testa, Luca; Brambilla, Nedy; Tusa, Maurizio; Bedogni, Francesco

    2016-04-01

    In the last years, a general shift toward the use of surgical bioprosthetic aortic valves rather than mechanical valves with subsequent less use of anticoagulant therapy has been observed. However, bioprosthetic valves have limited durability. Reoperation, the current standard of care for these patients, carries a high surgical risk, especially because patients are elderly and with numerous comorbidities. Recently, transcatheter aortic valve replacement within a failed bioprosthetic valve (valve-in-valve procedure) has proven feasible. We here describe a case of valve-in-valve procedure with a Portico valve placed in a purely insufficient bioprosthetic valve (Biocor). PMID:27093211

  16. TERESSÜL OF AHMED-İ DÂİ AHMED-İ DÂÎNİN TERESSÜLÜ

    Directory of Open Access Journals (Sweden)

    Halil İbrahim HAKSEVER

    2011-01-01

    Full Text Available Ahmed Dai is a major poet in 14-15 century. Teressül which is one of the most among the works is initial work has known now variety of Münşeat in Turkish literature. The work explains rules of letter writing procedure. Unique and insufficient copy of the work in our hands is registered at the Manisa Muradiye Library 1856/3. The work consists of 9 sheets. Ahmet Dai indicates that it is written out with unsophisticated Turkish in order to be helpful and useful, it is made a beginning with basmala, glorification and pray in compliance with islamic traditions. The author had put in order 10 number of rules of letter writing under the title of “politeness” after that he had given information about caption and sobriquet as writing a letter to formal and informal person. Three number of representative sample of letters are also given a place in the work. Text of copy in our hands finished before third letter finished.Further representative samples of letter might be present in original text written out by the writer. Ahmed-i Dâî 14-15. yüzyılın büyük şairlerindendir. Eserleri arasında önemli bir yere sahip olan Teressül, Türk edebiyatında münşeat türünün şimdilik bilinen ilk eseridir. Eser mektup yazma usul ve kurallarını anlatır. Eserin elimizdeki tek ve eksik bir nüshası Manisa Muradiye Kütüphanesi 1856/3’te kayıtlıdır.Eser 9 yapraktan ibarettir. Ahmed Daî eserini faydalı ve kullanışlı olması için sade bir Türkçe ile kaleme aldığını belirtmiş; İslamî geleneğe uygun olarak besmele, hamd ve dua ile başlamıştır. Yazar “edeb” başlığı altında on tane mektup yazma kuralı sıralamış, sonra resmî ve gayrı resmî kişilere mektup yazarken kullanılacak ünvan ve lâkapları vermiştir. Eserde üç tane de temsilî mektup örneğine yer verilmiştir. Üçüncü mektup bitmeden elimizdeki nüsha metni sona ermiştir.Yazarın kaleme aldığı orijinal metinde muhtemelen başka mektup

  17. Piezoelectric valve

    Science.gov (United States)

    Petrenko, Serhiy Fedorovich

    2013-01-15

    A motorized valve has a housing having an inlet and an outlet to be connected to a pipeline, a saddle connected with the housing, a turn plug having a rod, the turn plug cooperating with the saddle, and a drive for turning the valve body and formed as a piezoelectric drive, the piezoelectric drive including a piezoelectric generator of radially directed standing acoustic waves, which is connected with the housing and is connectable with a pulse current source, and a rotor operatively connected with the piezoelectric generator and kinematically connected with the rod of the turn plug so as to turn the turn plug when the rotor is actuated by the piezoelectric generator.

  18. Valve's Way

    DEFF Research Database (Denmark)

    Foss, Nicolai Juul; Dobrajska, Magdalena

    2015-01-01

    what extent it represents a new blueprint for organization design, despite it being consistent with an “egalitarian Zeitgeist” (Puranam, 2014). In fact, managerial authority may be of increasing importance rather than the opposite (Guadalupe, Li, & Wulf, 2015). Thus, Valve is, and will remain, an...

  19. Glaucoma and optic nerve repair.

    Science.gov (United States)

    Diekmann, Heike; Fischer, Dietmar

    2013-08-01

    Glaucoma is a leading cause of irreversible blindness worldwide and causes progressive visual impairment attributable to the dysfunction and death of retinal ganglion cells (RGCs). Progression of visual field damage is slow and typically painless. Thus, glaucoma is often diagnosed after a substantial percentage of RGCs has been damaged. To date, clinical interventions are mainly restricted to the reduction of intraocular pressure (IOP), one of the major risk factors for this disease. However, the lowering of IOP is often insufficient to halt or reverse the progress of visual loss, underlining the need for the development of alternative treatment strategies. Several lines of evidence suggest that axonal damage of RGCs occurs primary at the optic nerve head, where axons appear to be most vulnerable. Axonal injury leads to the functional loss of RGCs and subsequently induces the death of the neurons. However, the detailed molecular mechanism(s) underlying IOP-induced optic nerve injury remain poorly understood. Moreover, whether glaucoma pathophysiology is primarily axonal, glial, or vascular remains unclear. Therefore, protective strategies to prevent further axonal and subsequent soma degeneration are of great importance to limit the progression of sight loss. In addition, strategies that stimulate injured RGCs to regenerate and reconnect axons with their central targets are necessary for functional restoration. The present review provides an overview of the context of glaucoma pathogenesis and surveys recent findings regarding potential strategies for axonal regeneration of RGCs and optic nerve repair, focusing on the role of cytokines and their downstream signaling pathways. PMID:23512141

  20. Selectively bonded polymeric glaucoma drainage device for reliable regulation of intraocular pressure.

    Science.gov (United States)

    Moon, Seunghwan; Im, Seongmin; An, Jaeyong; Park, Chang Ju; Kim, Hwang Gyun; Park, Sang Woo; Kim, Hyoung Ihl; Lee, Jong-Hyun

    2012-04-01

    A novel glaucoma drainage device (GDD) using a polymeric micro check valve with no reverse flow is presented for the effective regulation of intraocular pressure (IOP). A significant functional improvement was achieved by reducing the possible incidence of hypotony, as the proposed GDD only drains aqueous humor at a certain cracking pressure or higher. The device consists of three biocompatible polymer layers: a top layer (cover), an intermediate layer (membrane), and a bottom layer (base plate with a cannula). All three layers, made of soft polydimethylsiloxane (PDMS), were bonded together to realize the thin GDDs. The bottom layer was selectively coated with chromium (Cr)/gold (Au) to prevent stiction between the valve seat and the valve orifice so that the device could show enhanced reliability in operation and high yield in production. Two types of polymeric devices were fabricated; one was a glaucoma drainage device for humans (GDDH) and the other was a glaucoma drainage device for animals (GDDA). From subsequent in vitro tests, the cracking pressures were 18.33 ± 0.66 mmHg (mean ± standard deviation) for GDDH and 12.42 mmHg for GDDA, both of which were very close to the corresponding normal IOPs. From in vivo tests of GDDA, the IOP of all implanted devices was properly regulated within the target pressure (10-15 mmHg). The experimental results showed that the proposed polymeric GDD has high potential for use in the treatment of glaucoma disease in terms of its repeatability of the cracking pressure and patients' relief from post-operative discomfort. PMID:22094823

  1. Effects of glaucoma medications on the cardiorespiratory and intraocular pressure status of newly diagnosed glaucoma patients

    OpenAIRE

    WALDOCK, A; Snape, J; Graham, C

    2000-01-01

    AIMS—To evaluate the short term cardiovascular, respiratory, and intraocular pressure (IOP) effects of four glaucoma medications in newly diagnosed glaucoma patients.
METHODS—141 newly diagnosed glaucoma patients were recruited and underwent a full ocular, cardiovascular, and respiratory examination, including an electrocardiogram (ECG) and spirometry. They were prescribed one of four topical glaucoma medications and reviewed 3 months later. One eye of each patient was randomly chosen for ana...

  2. Ahmed Zakajev: Litvinenko tapeti, sest ta abistas omakasupüüdmatult tšetšeene / Tõnis Erilaid

    Index Scriptorium Estoniae

    Erilaid, Tõnis, 1943-

    2007-01-01

    Vene ajalehes Kommersant ilmus intervjuu endise Itškeeria ministri Ahmed Zakajeviga, kes ei kahtle, et Aleksandr Litvinenko tapmisega on seotud Andrei Lugovoi. Suurbritannia politsei tegutseb täie tõsidusega, et sundida Venemaad Andrei Lugovoid välja andma

  3. Comparison of Delayed-Onset Glaucoma and Early-Onset Glaucoma after Infantile Cataract Surgery

    OpenAIRE

    Kang, Kui Dong; Yim, Hye Bin; Biglan, Albert W.

    2006-01-01

    Purpose To investigate the causes and characteristics of glaucoma in children following cataract surgery. Methods Twenty-four patients (37 eyes) with uncomplicated congenital cataracts who developed glaucoma after cataract surgery were studied retrospectively. Variables included cataract morphology, surgical techniques, post-operative complications, time to the onset of glaucoma, gonioscopic findings, presence of microcornea and the histopathologic characteristics of the filtration angle (in ...

  4. Glaucoma Alters the Circadian Timing System

    OpenAIRE

    Drouyer, Elise; Dkhissi-Benyahya, Ouria; Chiquet, Christophe; WoldeMussie, Elizabeth; Ruiz, Guadalupe; Wheeler, Larry A.; Denis, Philippe; Cooper, Howard M.

    2008-01-01

    Glaucoma is a widespread ocular disease and major cause of blindness characterized by progressive, irreversible damage of the optic nerve. Although the degenerative loss of retinal ganglion cells (RGC) and visual deficits associated with glaucoma have been extensively studied, we hypothesize that glaucoma will also lead to alteration of the circadian timing system. Circadian and non-visual responses to light are mediated by a specialized subset of melanopsin expressing RGCs that provide photi...

  5. Consumer Perceptions of Brand Trust Online of Clothing in Karachi: A case study of Gul Ahmed

    Directory of Open Access Journals (Sweden)

    Amna Javed

    2014-03-01

    Full Text Available Online purchase, in the clothing industry of Pakistan, is on a historical high. There are various factors that affect the brand trust of online consumers. This research is aimed to find the correlation between security and privacy of personal information, name of the brand, word-of-mouth, prior online experience and information quality on the one hand and the online brand trust of consumers on the other. The study is conducted in relation to a single brand, named Gul Ahmed. The sample for this study contained 387 respondents. The results of the study show that all these factors have a significant relationship with online brand trust. Word of mouth however, has been found to have the strongest correlation with the online brand trust.

  6. High-order large-eddy simulation of flow over the ``Ahmed body'' car model

    Science.gov (United States)

    Minguez, M.; Pasquetti, R.; Serre, E.

    2008-09-01

    The structure of the turbulent flow over a simplified automotive model, the Ahmed body (S. R. Ahmed and G. Ramm, SAE Paper No. 8403001, 1984) with a 25° slanted back face, is investigated using high-order large-eddy simulations (LESs) at Reynolds number Re =768000. The numerical approach is carried out with a multidomain spectral Chebyshev-Fourier solver and the bluff body is modeled with a pseudopenalization method. The LES capability is implemented thanks to a spectral vanishing viscosity (SVV) technique, with particular attention to the near wall region. Such a SVV-LES approach is extended for the first time to an industrial three-dimensional turbulent flow over a complex geometry. In order to better understand the interactions between flow separations and the dynamic behavior of the released vortex wake, a detailed analysis of the flow structures is provided. The topology of the flow is well captured showing a partial separation of the boundary layer over the slanted face and the occurrence of two strong contrarotating trailing vortices expanding farther in the wake. The interactions of these large vortices with smaller structures reminiscent of horseshoe vortices, within the shear layer over the slanted face, form large helical structures providing strong unsteady phenomena in the wake. Mean velocity fields and turbulence statistics show a global agreement with the reference experiments of Lienhart et al. (DGLR Fach Symposium der AG SRAB, Stuttgart University, 15-17 November 2000). In order to provide a deeper insight into the nature of turbulence, the flow is analyzed using power spectra and the invariant theory of turbulence of Lumley [Adv. Appl. Mech. 18, 123 (1978)].

  7. Aortic valve bypass

    DEFF Research Database (Denmark)

    Lund, Jens T; Jensen, Maiken Brit; Arendrup, Henrik; Ihlemann, Nikolaj

    2013-01-01

    In aortic valve bypass (AVB) a valve-containing conduit is connecting the apex of the left ventricle to the descending aorta. Candidates are patients with symptomatic aortic valve stenosis rejected for conventional aortic valve replacement (AVR) or transcatheter aortic valve implantation (TAVI...

  8. NOVELTIES IN MEDICAL TREATMENT OF GLAUCOMA.

    Science.gov (United States)

    Cornel, Stefan; Mihaela, Timaru Cristina; Adriana, Iliescu Daniela; Mehdi, Batras; Algerino, De Simone

    2015-01-01

    The purpose of this study is to review the current medical treatment and the new and better alternatives for patients with glaucoma. Glaucoma refers to a group of related eye disorders that have in common an optic neuropathy associated with visual function loss. It is one of the leading causes of irreversible blindness worldwide. Glaucoma can damage vision gradually so it may not be noticed until the disease is at an advanced stage. Early diagnosis and treatment can minimize or prevent optic nerve damage and limit glaucoma-related vision loss. Nowadays, research continues for the improvement of current medical treatment. PMID:26978866

  9. Radiotherapy of glaucoma absolutum dolorosum

    International Nuclear Information System (INIS)

    During the period 1980-1982 the authors applied X-ray therapy to 47 patients with painful glaucoma, unaffected by drug treatment. X-ray therapy was generated at 100 KV and half-decreasing 3 mm aluminium. Surface dose from 0,50 to 0,70 Gy was applied at 2-3 day intervals, total 4-6 times. All patients were followed up over a period from 1 to 3 years. The inflammatory changes disappeared in all patients, and pain was not relieved in only one patient. Ocular tension remained elevated in 15 patients and in 32 was reduced to a different degree. No radiation injury, occuring during the observation period, was recorded. The results justify X-ray therapy in patients with painful glaucoma

  10. Mitral Valve Disease

    Science.gov (United States)

    ... Tricuspid Valve Disease Cardiac Rhythm Disturbances Thoracic Aortic Aneurysm Pediatric and Congenital Heart Disease Heart abnormalities that are ... Transplantation End-stage Lung Disease Adult Lung Transplantation Pediatric Lung ... Aortic Aneurysm Mitral Valve Disease Overview The mitral valve is ...

  11. Prevalence of open angle glaucoma in accompanying first degree relatives of patients with glaucoma

    Directory of Open Access Journals (Sweden)

    Franciele Vegini

    2008-01-01

    Full Text Available OBJECTIVE: The aim of this study was to determine the prevalence of open angle glaucoma in first-degree relatives accompanying POAG patients during routine examination in a reference hospital. METHOD: First-degree relatives of primary open angle glaucoma patients who accompanied their relatives to the glaucoma service of a reference hospital were screened for glaucoma. RESULTS: One-hundred and one first-degree relatives were examined, of which 56.4% had never had their intraocular pressure measured. 10.9% had previously been diagnosed with glaucoma, and 5.9% were newly diagnosed during this study. CONCLUSIONS: The eye examination of first-degree relatives identified a significant percentage of individuals with glaucoma. Despite being first-degree relatives of glaucoma patients, 56.4% of the companions had never had their eye pressure measured, demonstrating a lack of awareness about this disease.

  12. Glaucoma and dry eye disease: the role of preservatives in glaucoma medications

    Directory of Open Access Journals (Sweden)

    Ratna Sitompul

    2011-11-01

    Full Text Available Glaucoma is a common cause of irreversible blindness with increasing prevalence. Some of glaucoma patients will also experience dry eye. Dry eye is the most frequent side effect related to benzalkonium chloride (BAC-containing eye drop  used for glaucoma patients. In addition, glaucoma and dry eyes have shared risk factors that are old age and female. Dry eye among glaucoma patients need to be treated promptly as it produces discomfort, reduces patients’ compliance and   decreases success rate of glaucoma therapy. Dry eye symptoms can be treated by applying preservative-free eye drop, giving combination of preservative containing and preservative-free eye drop to reduce BAC exposure, prescribing artificial tear and conducting surgery to minimize or eliminate the need of topical medication. (Med J Indones 2011; 20:302-5Keywords: benzalkonium chloride, dry eye, glaucoma

  13. Normal tension glaucoma and Alzheimer disease

    DEFF Research Database (Denmark)

    Bach-Holm, Daniella; Kessing, Svend Vedel; Mogensen, Ulla;

    2012-01-01

    PURPOSE: To investigate whether normal tension glaucoma (NTG) is associated with increased risk of developing dementia/Alzheimer disease (AD). METHODS: A total of 69 patients with NTG were identified in the case note files in the Glaucoma Clinic, University Hospital of Copenhagen (Rigshospitalet...

  14. Melanocytic glaucoma in a cairn terrier.

    Science.gov (United States)

    Hanselman, Beth A

    2002-04-01

    Melanocytic glaucoma, previously known as pigmentary glaucoma, is characterized by diffuse intraocular infiltration of heavily pigmented melanocytes. This unusual ocular disorder has been documented only in the cairn terrier and is considered familial. Treatment strategies are based on evidence that the condition is slowly progressive but not neoplastic. PMID:11963666

  15. The optic nerve head in glaucoma

    OpenAIRE

    Rupert RA Bourne

    2006-01-01

    ll types of glaucoma involve glaucomatous optic neuropathy. The key to detection and management of glaucoma is understanding how to examine the optic nerve head (ONH). This pictorial glossary addresses the following issues: how to examine the ONH; normal characteristics of the ONH; characteristics of a glaucomatous ONH; how to tell if the glaucomatous optic neuropathy is getting worse;‘pitfalls and pearls’.

  16. Determinants of glaucoma awareness in urban punjab

    International Nuclear Information System (INIS)

    To assess the awareness about glaucoma and the factors affecting it in urban Punjab population. Study Design: Cross-sectional study. Place and Duration of Study: Study was conducted in March-April 2011 in Rawalpindi District Punjab, Pakistan. Material and Methods: Glaucoma awareness study was conducted on urban population of Rawalpindi, Islamabad, Lahore and Taxila. Individuals belonging to medical profession (doctors, nurses and paramedics etc) were not included. Demographic details and educational status of all participants were documented. A brief structured close-ended study questionnaire was used to collect information about their awareness of risk factors, treatment aspects and complication of glaucoma. Results: There were 729 participants in the study. Majority were females (60.1%) and adults (76.1%). Literacy level of 40.2% was up to matriculate level. The study indicated that the awareness level about glaucoma was low especially about the recognition of high-risk groups and symptoms. Only one-third of respondents i.e. 32.6% had an idea about the symptoms of the disease and 27.4% participants had awareness of glaucoma as a blinding eye disease. Determinants of glaucoma awareness amongst study participants were gender, age, education level and occupation. Conclusion: Awareness of glaucoma was quite low among the urban population in Punjab. There is need of increased public health education to reduce glaucoma associated blindness and its burden on society. (author)

  17. A NEW SIHHAT-NÂME THE SEHDÎ’S SIHHAT-NÂME FOR SULTAN AHMED III / YENI BIR SIHHÂT-NÂME SEHDÎ’NIN SULTAN III. AHMED SIHHAT-NÂME’SI

    Directory of Open Access Journals (Sweden)

    Dr. Bahir SELÇUK

    2008-05-01

    Full Text Available The Divan poets on various occcasions presented poemsprimarly to sultans and notable statesmen of the period. Onekind of these poems is the sıhhat-nâme written poems for therecovery of sultans of a disease. In our classical kind ofpoems the sıhhat-nâme was mostly written for III. SultanAhmed. One of the sıhhat-nâmes written for Sultan Ahmed isavailable in the collected poems of Sehdi who is from Antakya.In this study, the poet of 18th century, the sıhhatnâmeof Sehdî, has been studied in terms of content and formby translating it into new Turkish alphabet.

  18. [Toward a high quality glaucoma care].

    Science.gov (United States)

    Kashiwagi, Kenji

    2012-03-01

    The following studies were performed to solve current problems in glaucoma care and to pursue quality glaucoma care. Using a scanning peripheral anterior chamber depth analyzer that we developed, we: 1) conducted cross-sectional screening for eyes with angle closure; 2) examined longitudinal changes in anterior chamber depth and occurrence rates of primary angle closure in local senior residents; 3) investigated the significance of the anterior chamber and the angle of eyes with open angle glaucoma; and 4) looked into possible applications of anterior chamber depth and the angle in routine examinations. We investigated the effects of retinal glial cells and optic nerve astrocytes on retinal ganglion cell (RGC) survival and neurite growth using a culture system. We also identified candidate genies of retinal glial cells and optic nerve astrocytes affecting RGC survival and neurite growth using microarray and siRNA systems. SRC, a membrane-associated 60-kDa tyrosine kinase, is reported to be involved in neuron death and neurite growth. We developed two types of gene-targeted mice in which we modified the status of SRC phosphorylation. We compared RGC survival and neurite growth by conducting in vivo and in vitro experiments. Adherence is currently a very important issue in the field of glaucoma. We developed a nm thick and composed of 21.5 chitosan-sodium alginate pairs. IOP reduction and its duration, as well as adverse effects, were investigated. In addition, we established and evaluated a support system for glaucoma care in an effort to promote participation of glaucoma patients in glaucoma care using information and communication technology. This system improved the literacy of glaucoma patients as well as glaucoma medical therapy. At the same time, in order to ably provide glaucoma care given the increase in the number of glaucoma patients and the shortage of glaucoma specialists, a tele-medicine system for ophthalmology was developed, in which ophthalmologists

  19. Animal models of glucocorticoid-induced glaucoma.

    Science.gov (United States)

    Overby, Darryl R; Clark, Abbot F

    2015-12-01

    Glucocorticoid (GC) therapy is widely used to treat a variety of inflammatory diseases and conditions. While unmatched in their anti-inflammatory and immunosuppressive activities, GC therapy is often associated with the significant ocular side effect of GC-induced ocular hypertension (OHT) and iatrogenic open-angle glaucoma. Investigators have generated GC-induced OHT and glaucoma in at least 8 different species besides man. These models mimic many features of this condition in man and provide morphologic and molecular insights into the pathogenesis of GC-OHT. In addition, there are many clinical, morphological, and molecular similarities between GC-induced glaucoma and primary open-angle glaucoma (POAG), making animals models of GC-induced OHT and glaucoma attractive models in which to study specific aspects of POAG. PMID:26051991

  20. Monitoring dynamics of aqueous humor in glaucoma

    International Nuclear Information System (INIS)

    Aqueous humor dynamics was observed in patients treated for glaucoma. Aqueous flow was measured using the radionuclide method of contact application of 22NaCl and the detection of gamma radiation with external detectors. The sample of 184 eyes was divided into three groups: open-angle glaucoma with therapy, open-angle glaucoma without therapy and angle-closure glaucoma 47 eyes were used as controls. Changes were observed in 22Na outflow half-time in dependence on the duration of the disease, therapy, intraocular pressUre and changes in the perimeter. The new technique has been fully proven in practice, is a contribution to the diagnosis of glaucoma and an indicator of the compensation of the disease. (author)

  1. Scanning the macula for detecting glaucoma

    Directory of Open Access Journals (Sweden)

    Viquar U Begum

    2014-01-01

    Full Text Available Background: With the advent of spectral domain optical coherence tomography (SDOCT, there has been a renewed interest in macular region for detection of glaucoma. However, most macular SDOCT parameters currently are thickness parameters which evaluate thinning of the macular layers but do not quantify the extent of area over which the thinning has occurred. We therefore calculated a new macular parameter, "ganglion cell complex surface abnormality ratio (GCC SAR" that represented the surface area over which the macular thickness was decreased. Purpose: To evaluate the ability of SAR in detecting perimetric and preperimetric glaucoma. Design: Retrospective image analysis. Materials and Methods: 68 eyes with perimetric glaucoma, 62 eyes with preperimetric glaucoma and 165 control eyes underwent GCC imaging with SDOCT. SAR was calculated as the ratio of the abnormal to total area on the GCC significance map. Statistical Analysis: Diagnostic ability of SAR in glaucoma was compared against that of the standard parameters generated by the SDOCT software using area under receiver operating characteristic curves (AUC and sensitivities at fixed specificities. Results: AUC of SAR (0.91 was statistically significantly better than that of GCC average thickness (0.86, P = 0.001 and GCC global loss volume (GLV; 0.88, P = 0.01 in differentiating perimetric glaucoma from control eyes. In differentiating preperimetric glaucoma from control eyes, AUC of SAR (0.72 was comparable to that of GCC average thickness (0.70, P > 0.05 and GLV (0.72, P > 0.05. Sensitivities at specificities of 80% and 95% of SAR were comparable (P > 0.05 for all comparisons to that of GCC average thickness and GLV in diagnosing perimetric and preperimetric glaucoma. Conclusion: GCC SAR had a better ability to diagnose perimetric glaucoma compared to the SDOCT software provided global GCC parameters. However, in diagnosing preperimetric glaucoma, the ability of SAR was similar to that of

  2. Son başmuvakkit Ahmed Ziya Bey’in Güneş saatleri tasarımıyla ilgili bir yazısı

    OpenAIRE

    Acar, Şinasi; Bir, Atilla; Kaçar, Mustafa

    2015-01-01

    A text on sundial design written by the last Ottoman chief-timekeeper Ahmed Ziya BeyIn Islam the prayer times are defined, according to the local position of the Sun. Therefore, sundials are generally used to designate the prayer times in Muslim communities. Islamic astronomers and timekeepers authored many treatises related to the theory and application of gnomonic. A representative of this tradition is the last Ottoman chief-timekeeper Ahmed Ziya [Akbulut]. He compiled a textbook on cosmogr...

  3. Glaucoma in aphakia and pseudophakia after congenital cataract surgery.

    OpenAIRE

    Mandal Anil; Netland Peter

    2004-01-01

    Glaucoma is one of the most common causes of visual loss despite successful congenital cataract surgery. The overall incidence does not appear to have decreased with modern microsurgical techniques. The onset of glaucoma may be acute or insidious and notoriously refractory to treatment. Angle closure glaucoma may occur in the early postoperative period; but the most common type of glaucoma to develop after congenital cataract surgery is open angle glaucoma. Several risk factors have been iden...

  4. [The denominations cataract and glaucoma].

    Science.gov (United States)

    Tornquist, R

    1997-01-01

    Since ancient times a grey or white pupil in an nearly blind eye was thought to be caused by a mucous substance in front of the lens. It was called "hypochysis" or "hypochyma" in Greece and "suffusio" in Rome. Later the term "cataract" (=waterfall) was the most popular denomination. A surgical method was tried very early with usually good effect, when with a thin needle, introduced into the eye, the opaque material was removed from the pupillary area. In the middle of the 17th century more careful investigations showed that there was no membrane in front of the lens, but the lens itself was opaque. The final proof was delivered when an extraction of the lens was performed with good effect. In ancient times incurable blindness, which was called glaucoma, was thought to be located to the lens, which probably had a very important role in the seeing process. The name (of Greek orgin) is translated "green" or "blue-green", which was sometimes notified to be the color of the lens, seen through the pupil, in these cases. A period of great confusion followed when the removal of this very important part of the eye did not lead to blindness but rather an improved vision. As there were significant difficulties in identifying the specific color of the pupil the name glaucoma seemed to be very inadequate. In the beginning of the 19th century a disease entity (which is to-day called acute closed-angle glaucoma) seemed to eventually fullfill the demand of a greenlooking pupil. The most characteristic symptoms are pain and a high intraocular pressure causing a corneal edema and a change of the blackness of the pupil to hazy grey (and maybe a little green?). PMID:11625470

  5. Microfluidic sieve valves

    Science.gov (United States)

    Quake, Stephen R; Marcus, Joshua S; Hansen, Carl L

    2015-01-13

    Sieve valves for use in microfluidic device are provided. The valves are useful for impeding the flow of particles, such as chromatography beads or cells, in a microfluidic channel while allowing liquid solution to pass through the valve. The valves find particular use in making microfluidic chromatography modules.

  6. Remote actuated valve implant

    Energy Technology Data Exchange (ETDEWEB)

    McKnight, Timothy E.; Johnson, Anthony; Moise, Kenneth J.; Ericson, Milton Nance; Baba, Justin S.; Wilgen, John B.; Evans, Boyd Mccutchen

    2016-05-10

    Valve implant systems positionable within a flow passage, the systems having an inlet, an outlet, and a remotely activatable valve between the inlet and outlet, with the valves being operable to provide intermittent occlusion of the flow path. A remote field is applied to provide thermal or magnetic activation of the valves.

  7. Zero-leak valve

    Science.gov (United States)

    Macglashan, W. F., Jr.

    1980-01-01

    Zero-leakage valve has fluid-sealing diaphragm support and flat sievelike sealing surface. Diaphragm-support valve is easy to fabricate and requires minimum maintenance. Potential applications include isolation valve for waste systems and remote air-actuated valve. Device is also useful in controlling flow of liquid fluorine and corrosive fluids at high pressures.

  8. Remote actuated valve implant

    Science.gov (United States)

    McKnight, Timothy E; Johnson, Anthony; Moise, Jr., Kenneth J; Ericson, Milton Nance; Baba, Justin S; Wilgen, John B; Evans, III, Boyd McCutchen

    2014-02-25

    Valve implant systems positionable within a flow passage, the systems having an inlet, an outlet, and a remotely activatable valve between the inlet and outlet, with the valves being operable to provide intermittent occlusion of the flow path. A remote field is applied to provide thermal or magnetic activation of the valves.

  9. Incidence of nutritional anaemia among the under five children attending Ahmed Gasim hospital

    International Nuclear Information System (INIS)

    A survey was carried out in Khartoum North Ahmed Gasim specialist Hospital for children to identify aetiological factors that lead to incidence of nutritional anaemia among children under under five years of age. The sample consists of 192 patients taken from the hospital wards (experimental group), and 60 healthy children taken from out patient vaccination department of same hospital. A questionnaire was used as a tool for collection data regarding children and their families with emphasis to general information, socio-economic information, dietary information, anthropometric information, medical history and laboratory investigations including haemoglobin, hematocrit (PCV)%, peripheral blood picture, serum ferritin, serum folate and serum B12. Results show no correlation between anaemia and age R(0.1048) p12 deficiency. Some children affected had mixed deficiency anaemia (3.182). Iron deficiency without anaemia was common among healthy children (control) 22.8%. Some recommendations were set for the improvement of the existing situation e.g. health education, nutrition education with emphasis on intake of supplements and weaning diets rich in iron and folate. Follow up and surveillance program to compact nutritional anaemia should be adopted.(Author)

  10. Glaucoma at the Hamilton Glaucoma Center and the University of California, San Diego

    Institute of Scientific and Technical Information of China (English)

    Robert N. Weinreb

    2011-01-01

    @@ Known for its unique cross-disciplinary investigative programs and clinical excellence, the scientists and clinicians at the Hamilton Glaucoma Center of the University of California, San Diego seek to enhance the discovery and translation of innovative research to clinical glaucoma care to prevent and cure glaucoma blindness.With state of the art laboratory and clinical facilities located on the La Jolla campus (Figure 1), the Center is a home for a worldrenowned team of scientists and staff.More than 100 post-doctoral fellows in Glaucoma, many of whom hold distinguished academic positions throughout the world, have been trained at the Hamilton Glaucoma Center and the University of California, San Diego.At the core of Hamilton Glaucoma Center activities are the outstanding faculty that are described below.

  11. Subconjunctival bevacizumab to augment trabeculectomy with mitomycin C in the management of failed glaucoma surgery

    Directory of Open Access Journals (Sweden)

    Saeed AM

    2014-09-01

    Full Text Available Ahmed M Saeed, Tarek Tawfeek AboulNasrOphthalmology Department, Benha University, Egypt Purpose: To provide a feasible solution to the problem of failed glaucoma surgery. The aim was to evaluate the efficacy and safety of the additional effects of a combined surgical approach. This approach augments the application of trabeculectomy with mitomycin C (MMC by adding subconjunctival bevacizumab injection. The results were compared with those of trabeculectomy with only adjunctive MMC. Methods: A randomized controlled prospective clinical trial included 28 eyes diagnosed with failed scarred bleb of a previous trabeculectomy. The eyes were divided into two equal groups: combined group A, “trabeculectomy with adjunctive MMC and subconjunctival bevacizumab,” and control group B, “trabeculectomy with adjunctive MMC only.” The main outcome results included the cumulative probability of surgical success, intraocular pressure (IOP values, and number of IOP-lowering medications needed to achieve the target IOP.Results: Group A achieved a cumulative probability of complete success of 0.769 and of qualified success of 0.231 at the end of the 24 month study period; group B achieved cumulative probabilities of 0.538 and 0.308, respectively. Group A achieved a lower mean IOP value than group B, with fewer antiglaucoma drugs at all postoperative visits, but this lower value did not reach a statistically significant level (P>0.05. There was no statistically significant difference between both groups regarding best corrected visual acuity, visual field parameters, operative and/or postoperative complications, and additional interventions. No significant adverse effects were caused by this combined approach.Conclusion: Bevacizumab was not found to add much to the favorable long-term outcome of conventional trabeculectomy with MMC as a solution to the problem of scarred failed bleb. Keywords: glaucoma, bevacizumab, mitomycin C, failed trabeculectomy

  12. Oral microbiome link to neurodegeneration in glaucoma.

    Directory of Open Access Journals (Sweden)

    Konstantin Astafurov

    Full Text Available BACKGROUND: Glaucoma is a progressive optic nerve degenerative disease that often leads to blindness. Local inflammatory responses are implicated in the pathology of glaucoma. Although inflammatory episodes outside the CNS, such as those due to acute systemic infections, have been linked to central neurodegeneration, they do not appear to be relevant to glaucoma. Based on clinical observations, we hypothesized that chronic subclinical peripheral inflammation contributes to neurodegeneration in glaucoma. METHODS: Mouthwash specimens from patients with glaucoma and control subjects were analyzed for the amount of bacteria. To determine a possible pathogenic mechanism, low-dose subcutaneous lipopolysaccharide (LPS was administered in two separate animal models of glaucoma. Glaucomatous neurodegeneration was assessed in the retina and optic nerve two months later. Changes in gene expression of toll-like receptor 4 (TLR4 signaling pathway and complement as well as changes in microglial numbers and morphology were analyzed in the retina and optic nerve. The effect of pharmacologic blockade of TLR4 with naloxone was determined. FINDINGS: Patients with glaucoma had higher bacterial oral counts compared to control subjects (p<0.017. Low-dose LPS administration in glaucoma animal models resulted in enhancement of axonal degeneration and neuronal loss. Microglial activation in the optic nerve and retina as well as upregulation of TLR4 signaling and complement system were observed. Pharmacologic blockade of TLR4 partially ameliorated the enhanced damage. CONCLUSIONS: The above findings suggest that the oral microbiome contributes to glaucoma pathophysiology. A plausible mechanism by which increased bacterial loads can lead to neurodegeneration is provided by experiments in animal models of the disease and involves activation of microglia in the retina and optic nerve, mediated through TLR4 signaling and complement upregulation. The finding that commensal

  13. Epidemiology and characteristics of childhood glaucoma: results from the Dallas Glaucoma Registry

    OpenAIRE

    Fung DS; Roensch MA; Kooner KS; Cavanagh HD; Whitson JT

    2013-01-01

    Derrick S Fung, M Allison Roensch, Karanjit S Kooner, H Dwight Cavanagh, Jess T WhitsonDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USAPurpose: Few studies have provided epidemiological characteristics of childhood glaucoma in a large, multiethnic population. This information is important if we are to better screen for and characterize this specific type of glaucoma. In this study, we evaluate the characteristics of patients with childhood glaucoma...

  14. Glaucoma Detection From Fundus Image Using Opencv

    OpenAIRE

    Narasimhan, K.; K.Vijayarekha; K.A. JogiNarayana; P Sivaprasad; V. SatishKumar

    2012-01-01

    This study proposes a semi automated method for glaucoma detection using CDR and ISNT ratio of a fundus image. CDR (Cup to Disc Ratio) is ratio of area of Optic Cup to area of Optic Disc. For a patient with glaucoma Optic Cup size increases while the Optic Disc size remains same and hence CDR will be high for glaucoma patient than normal fundus image. The ROI of green plane is taken and K-Means clustering technique is recursively applied and Optic Disc and Optic Cup is segmented. Through elli...

  15. Prevalence and determinants of glaucoma : an epidemiologic approach (The Rotterdam Study)

    OpenAIRE

    Dielemans, Ida

    1995-01-01

    textabstractGlaucoma is an eye disease characterized by damage to the optic nerve head and related visual field defects, often accompanied by elevated intraocular pressure. Glaucoma is an important cause of blindness, particularly in the elderly. One may divide glaucoma in primary glaucoma without known preceding cause, and secundary glaucoma. Primary glaucoma may be genetically determined. The term secundary glaucoma refers to glaucoma caused by some known antecedent or concomitant ocular di...

  16. Intrabronchial Valves

    Science.gov (United States)

    Mahajan, Amit Kumar; Verhoef, Philip; Patel, Shruti B.; Carr, Gordon; Hogarth, Douglas Kyle

    2016-01-01

    Background Bronchopleural fistulas (BPF) are conditions associated with prolonged hospital course, high morbidity, and possibly increased mortality. The presence of BPFs in critically ill patients may cause difficulty in ventilation and increased oxygen requirements. Intrabronchial valves (Spiration IBV) serve as a noninvasive therapeutic option for the closure of BPFs. Methods This report is a retrospective description of 3 patients transferred to our medical intensive care unit (ICU) with BPFs and persistent air leaks (PAL). One patient required high levels of oxygen supplementation through a nonrebreather face mask, whereas 2 required mechanical ventilation because of respiratory failure. IBVs were placed in each patient with the intention of closing their BPF and weaning them from respiratory support. Results The use of IBVs in ICU patients with BPFs and PALs resulted in 1 patient being weaned from the persistent need for a nonrebreather face mask to room air and also aided in the liberation from mechanical ventilation of 2 patients who had been failing spontaneous breathing trials. Conclusions The use of IBVs is safe and well tolerated in ICU patients with BPFs and PALs. The placement of IBVs results in significant clinical improvement, allowing for either weaning from high levels of oxygen support or liberation from mechanical ventilation. PMID:23207358

  17. Pîr Ahmed Efendi, The Sheikh of Kalburcu, and Understanding of Alevîs in the Sample of Sofca

    Directory of Open Access Journals (Sweden)

    Rıfat Türkel

    2016-06-01

    Full Text Available Pir Ahmed Efendi is an important person who lived in Kütahya at XVI. century and arrived scholars from line of his family as Müfti Dervis, Sunullâh-ı Gaybi. Pir Ahmed Efendi who had been respected at his period, has been recalled to the present day by varied sections. However, he has been appropriated by Alevi’s from begining from second part of XX. century, up to the present. He is still honoured between Alevi’s at the state and in Sofca in which his grave is located in. Besides, there still is a household under his name and students in it. That’s why in this work we aimed to present Pir Ahmed Efendi, and to determine Alevi perception in Sofca. We gave some information first about Pir Ahmed Efendi’s life by using writing sources in order to make Alevi perception more clear in Sofca and Pir Ahmed household. Then, we have mentioned about understanding of Pir Ahmed Efendi in todays Sofca. Subsequently we tried to determine Alevi understanding of “Koculu Household” which is Alevi’s of Sofca are connected, Seyyid Kemal Sultan Household and the House that bear the name Pir Ahmed Efendi from the point of basic belief and worshipping. We compared it to the traditional Alevi understanding in places. To do all of these we used quantitative researches instead of qualitative researches. And for provision we made an interview to mentors of mentioned households and students in Eskisehir, Kutahya and Sofca.

  18. Genetics Home Reference: early-onset glaucoma

    Science.gov (United States)

    ... medical conditions including high blood pressure (hypertension) and diabetes mellitus, as well as family history. The risk of early-onset glaucoma depends mainly on heredity. Structural abnormalities that impede ...

  19. Surgical consequences in coexisting cataract and glaucoma.

    Science.gov (United States)

    Blumenthal, M; Glovinsky, Y

    1995-04-01

    Of the three classical approaches to surgery for coexisting cataract and glaucoma, last year's publications dealt with the surgical consequences of combined cataract and glaucoma operations only. When used in combined cataract and glaucoma surgery, a small-incision extracapsular cataract extraction (ECCE) with phacoemulsification (PHACO) was found to be only slightly superior to the standard manual ECCE in terms of postoperative intraocular pressure (IOP) control. Injections of 5-fluorouracil postoperatively did not improve IOP control in PHACO-ECCE-trabeculectomy or manual ECCE-trabeculectomy. A preliminary uncontrolled report suggests, however, that intraoperative mitomycin C application in PHACO-ECCE-trabeculectomy may result in excellent postoperative IOP control without antiglaucomatous medications, and with no significant mitomycin C-related complications. Controlled studies on mitomycin C application in small-incision cataract and glaucoma surgery are needed to assess its long-term effect on IOP and astigmatism. PMID:10150852

  20. The role of inflammation in the pathogenesis of glaucoma

    DEFF Research Database (Denmark)

    Vohra, Rupali; Tsai, James C; Kolko, Miriam

    2013-01-01

    Glaucoma is an ocular disorder characterized by the progressive loss of retinal ganglion cells (RGC) and their axons. There are various hypotheses concerning the cause of RGC death. Previously, glaucoma was defined by high intraocular pressure (IOP); during the past decade, however, glaucoma...... specialists have acknowledged that elevated IOP is the most important risk factor for glaucoma, but does not define the disease. Other factors such as genetics, blood flow, and excitotoxicity are suggested as potential causal factors for progressive RGC death observed in glaucoma. We review recent studies...... elucidating a possible role of low-grade inflammation as a causal factor in the pathogenesis of glaucoma....

  1. Which valve is which?

    Directory of Open Access Journals (Sweden)

    Pravin Saxena

    2015-01-01

    Full Text Available A 25-year-old man presented with a history of breathlessness for the past 2 years. He had a history of operation for Tetralogy of Fallot at the age of 5 years and history suggestive of Rheumatic fever at the age of 7 years. On echocardiographic examination, all his heart valves were severely regurgitating. Morphologically, all the valves were irreparable. The ejection fraction was 35%. He underwent quadruple valve replacement. The aortic and mitral valves were replaced by metallic valve and the tricuspid and pulmonary by tissue valve.

  2. Current concepts in the pathophysiology of glaucoma

    OpenAIRE

    Agarwal Renu; Gupta Suresh; Agarwal Puneet; Saxena Rohit; Agrawal Shyam

    2009-01-01

    Glaucoma, the second leading cause of blindness, is characterized by changes in the optic disc and visual field defects. The elevated intraocular pressure was considered the prime factor responsible for the glaucomatous optic neuropathy involving death of retinal ganglion cells and their axons. Extensive investigations into the pathophysiology of glaucoma now reveal the role of multiple factors in the development of retinal ganglion cell death. A better understanding of the pathophysiological...

  3. Gene therapy in glaucoma-3: Therapeutic approaches

    Directory of Open Access Journals (Sweden)

    Mohamed Abdel-Monem Soliman Mahdy

    2010-01-01

    Recently, several promising genetic therapeutic approaches had been investigated. Some are either used to stop apoptosis and halt further glaucomatous damage, wound healing modulating effect or long lasting intraocular pressure lowering effects than the conventional commercially available antiglaucoma medications. Method of Literature Search The literature was searched on the Medline database using the PubMed interface. The key words for search were glaucoma, gene therapy, and genetic diagnosis of glaucoma.

  4. The optic nerve head in glaucoma

    Directory of Open Access Journals (Sweden)

    Rupert RA Bourne

    2006-09-01

    Full Text Available ll types of glaucoma involve glaucomatous optic neuropathy. The key to detection and management of glaucoma is understanding how to examine the optic nerve head (ONH. This pictorial glossary addresses the following issues: how to examine the ONH; normal characteristics of the ONH; characteristics of a glaucomatous ONH; how to tell if the glaucomatous optic neuropathy is getting worse;‘pitfalls and pearls’.

  5. Electroconvulsive therapy in a patient with glaucoma.

    Science.gov (United States)

    Amritwar, Ameya; Karia, Sagar; De Sousa, Avinash; Sonavane, Sushma

    2016-01-01

    There is little information on the use of electroconvulsive therapy (ECT) in the presence of glaucoma. An elderly man with known severe depression underwent surgery for cataract and glaucoma in the left eye. His depression worsened in the postoperative period and he required two sessions of ECT within 2 months of the surgery. There were no ophthalmic complications or adverse events associated with ECT and he responded well to treatment. PMID:27586212

  6. Minimally Invasive Aortic Valve Replacement

    Medline Plus

    Full Text Available ... in our practice, those being tissue valves and mechanical valves. Tissue valves, if I can demonstrate here, ... can expect. This is an example of a mechanical heart valve which is made out of pyrolitic ...

  7. Minimally Invasive Aortic Valve Replacement

    Medline Plus

    Full Text Available ... up offering patients aortic valve surgery in our community. Aortic stenosis is a process by which the ... basic valve types that we use in our practice, those being tissue valves and mechanical valves. Tissue ...

  8. The role of matricellular proteins in glaucoma.

    LENUS (Irish Health Repository)

    Wallace, Deborah M

    2014-07-01

    Glaucoma is an optic neuropathy affecting approximately 60million people worldwide and is the second most common cause of irreversible blindness. Elevated intraocular pressure (IOP) is the main risk factor for developing glaucoma and is caused by impaired aqueous humor drainage through the trabecular meshwork (TM) and Schlemm\\'s canal (SC). In primary open angle glaucoma (POAG), this elevation in IOP in turn leads to deformation at the optic nerve head (ONH) specifically at the lamina cribrosa (LC) region where there is also a deposition of extracellular matrix (ECM) molecules such as collagen and fibronectin. Matricellular proteins are non-structural secreted glycoproteins that help cells communicate with their surrounding ECM. This family of proteins includes connective tissue growth factor (CTGF), also known as CCN2, thrombospondins (TSPs), secreted protein acidic and rich in cysteine (SPARC), periostin, osteonectin, and Tenascin-C and -X and other ECM proteins. All members appear to play a role in fibrosis and increased ECM deposition. Most are widely expressed in tissues particularly in the TM and ONH and deficiency of TSP1 and SPARC have been shown to lower IOP in mouse models of glaucoma through enhanced outflow facility. The role of these proteins in glaucoma is emerging as some have an association with the pathophysiology of the TM and LC regions and might therefore be potential targets for therapeutic intervention in glaucoma.

  9. THE RELATIONSHIP OF METER AND SPELLING IN TEXTS WRITTEN BY OLD LETTERS ACCORDING TO THE AHMED-I RIDVAN'S DIVAN / AHMED-I RIDVAN DIVANI'NA GÖRE ESKI HARFLI METINLERDE VEZIN-IMLÂ ILISKISI

    Directory of Open Access Journals (Sweden)

    Dr. Halil ÇELTİK

    2008-11-01

    Full Text Available The spellings of articles with of letters differ according to theirpages and periods. To display the features of Turkish poem, thespelling which poets and writers have used in different periods shouldbe determined.Here, the spelling features in the Divan of Ahmed-i Rıdvan havebeen studied and the relation between spelling and meter is drawnattention.In this study, the changes in spelling which stem from meterhave been pointed out and these changes have been exemplified. Inaddition, this question "how and to what does the changes in spellingreflect translation" is wanted to discuss.

  10. Swing check valve

    International Nuclear Information System (INIS)

    A swing check valve which includes a valve body having an inlet and outlet is described. A recess in the valve body designed to hold a seal ring and a check valve disc swingable between open and closed positions. The disc is supported by a high strength wire secured at one end in a support spacer pinned through bearing blocks fixed to the valve body and at its other end in a groove formed on the outer peripheral surface of the disc. The parts are designed and chosen such to provide a lightweight valve disc which is held open by minimum velocity of fluid flowing through the valve which thus reduces oscillations and accompanying wear of bearings supporting the valve operating parts. (Auth.)

  11. Aortic Valve Disease

    Science.gov (United States)

    ... valve opens when the left ventricle squeezes to pump out blood, and closes in between heart beats to keep ... the left ventricle has to work harder to pump blood out through the valve. To do this extra ...

  12. Mitral valve prolapse

    Science.gov (United States)

    ... seen with some connective tissue disorders such as Marfan syndrome and other rare genetic disorders. Symptoms Many ... 66. Read More Atrial septal defect (ASD) Endocarditis Marfan syndrome Mitral valve surgery - minimally invasive Mitral valve ...

  13. AHM1, a novel type of nuclear matrix-localized, MAR binding protein with a single AT hook and a J domain-homologous region.

    Science.gov (United States)

    Morisawa, G; Han-Yama, A; Moda, I; Tamai, A; Iwabuchi, M; Meshi, T

    2000-10-01

    Interactions between the nuclear matrix and special regions of chromosomal DNA called matrix attachment regions (MARs) have been implicated in various nuclear functions. We have identified a novel protein from wheat, AT hook-containing MAR binding protein1 (AHM1), that binds preferentially to MARs. A multidomain protein, AHM1 has the special combination of a J domain-homologous region and a Zn finger-like motif (a J-Z array) and an AT hook. For MAR binding, the AT hook at the C terminus was essential, and an internal portion containing the Zn finger-like motif was additionally required in vivo. AHM1 was found in the nuclear matrix fraction and was localized in the nucleoplasm. AHM1 fused to green fluorescent protein had a speckled distribution pattern inside the nucleus. AHM1 is most likely a nuclear matrix component that functions between intranuclear framework and MARs. J-Z arrays can be found in a group of (hypothetical) proteins in plants, which may share some functions, presumably to recruit specific Hsp70 partners as co-chaperones. PMID:11041885

  14. Ahmed-i Bîcân'ın Nesir Üslübuna Dair Tespitler

    Directory of Open Access Journals (Sweden)

    Ferudun Hakan Özkan

    2012-04-01

    Full Text Available Turkish prose has been criticized and merely condemned to nonexistence with personal and unjust reviews such as the allegation of being weak and inadequate. It is a clear fact that these kinds of accusations are superficial and do not based upon a profound and complete research and investigation. The reason why prose stayed in the background in Turkish literature is not because poems are dominant and prose writings have a difficult and complicated structure; it is more about the ideological and merciless point of view towards the past especially in Tanzimat and Republic eras. The reviews of Turkish prose writings which are less in number compared to poetry, will make contributions to remove the aforementioned unfair attitudes and prejudices, and manifest that there is a well-protected and registered Turkish prose tradition either. Yazıcıoğulları family has a crucial place in terms of Turkish culture and social system. A member of this family, Yazıcıoğlu Ahmed-i Bîcân emerge as a special man with his eight writings some of which are compile works and seven of them are prose writings. Ahmed-i Bîcân, whose primary purpose was to enlighten the community, is an important figure not only in his contributions to the social system, but also in the development of Turkish prose in 15th century. In this paper we intended to place the writings of Ahmed-i Bîcân within the Turkish prose tradition.

  15. Glaucoma

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  17. Glaucoma

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  19. Glaucoma

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  20. Glaucoma

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  1. Glaucoma

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  2. Glaucoma

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  7. Glaucoma

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    Full Text Available ... comments to the NEI Office of Science Communications, Public Liaison, and Education. Technical questions about this website can be addressed to the NEI Website Manager . Department of Health and Human Services | The National Institutes of Health | ...

  8. Glaucoma

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  9. Glaucoma

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    Full Text Available ... the NEI Website NEI on Social Media | Search A-Z | en español | Text size S M L Toggle navigation ... mail updates AGI updates NEI Home Contact Us A-Z Site Map Information in Spanish (Información en español) ...

  10. Glaucoma

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    Full Text Available ... of the NEI Donating to the NEI Health Information Eye Health Topics Clinical Studies Publications Catalog Photos and Images Spanish Language Information News and Events All News Meetings and Events ...

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    Full Text Available ... Age-Related Macular Degeneration Amblyopia Animations Blindness Cataract Convergence Insufficiency Diabetic Eye Disease Dilated Eye Exam Dry ... and comments to the NEI Office of Science Communications, Public Liaison, and Education. Technical questions about this ...

  12. Glaucoma

    Science.gov (United States)

    ... Age-Related Macular Degeneration Amblyopia Animations Blindness Cataract Convergence Insufficiency Diabetic Eye Disease Dilated Eye Exam Dry ... and comments to the NEI Office of Science Communications, Public Liaison, and Education. Technical questions about this ...

  13. Glaucoma

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    Full Text Available ... Donating to the NEI Health Information Diseases and Disorders Clinical Studies Publications Catalog Photos and Images Spanish ... Linkedin NEI RSS NEHEP on Twitter NEHEP on Facebook NEHEP on Flickr NEHEP Newsletter E-mail updates ...

  14. Glaucoma

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  15. Glaucoma

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    Full Text Available ... Information in Spanish (Información en español) Website, Social Media Policies ... Office of Science Communications, Public Liaison, and Education. Technical questions about this ...

  16. Glaucoma

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    Full Text Available ... the NEI Donating to the NEI Health Information Eye Health Topics Clinical Studies Publications Catalog Photos and ... the Clinical Director Education Programs All Education National Eye Health Education Program Diabetic Eye Disease Education Program ...

  17. Is Estrogen a Therapeutic Target for Glaucoma?

    Science.gov (United States)

    Dewundara, Samantha S; Wiggs, Janey L; Sullivan, David A; Pasquale, Louis R

    2016-01-01

    This article's objective is to provide an overview of the association between estrogen and glaucoma. A literature synthesis was conducted of articles published in peer-reviewed journals screened through May 5, 2015, using the PubMed database. Keywords used were "estrogen and glaucoma," "reproductive factors and glaucoma," and "estrogen, nitric oxide and eye." Forty-three journal articles were included. Results indicated that markers for lifetime estrogen exposure have been measured by several studies and show that the age of menarche onset, oral contraceptive (OC) use, bilateral oophorectomy, age of menopause onset and duration between menarche to menopause are associated with primary open-angle glaucoma (POAG) risk. The Blue Mountain Eye Study found a significantly increased POAG risk with later (>13 years) compared with earlier (≤12 years) age of menarche. Nurses' Health Study (NHS) investigators found that OC use of greater than 5 years was associated with a 25% increased risk of POAG. The Mayo Clinic Cohort Study of Oophorectomy and Aging found that women who underwent bilateral oophorectomy before age 43 years had an increased risk of glaucoma. The Rotterdam Study found that women who went through menopause before reaching the age of 45 years had a higher risk of open-angle glaucoma (2.6-fold increased risk), while the NHS showed a reduced risk of POAG among women older than 65 who entered menopause after age ≥ 54 years. Increased estrogen states may confer a reduced risk of glaucoma or glaucoma-related traits such as reduced intraocular pressure (IOP). Pregnancy, a hyperestrogenemic state, is associated with decreased IOP during the third trimester. Though the role of postmenopausal hormone (PMH) use in the reduction of IOP is not fully conclusive, PMH use may reduce the risk of POAG. From a genetic epidemiologic perspective, estrogen metabolic pathway single nucleotide polymorphisms (SNPs) were associated with POAG in women and polymorphisms in

  18. Isolated Pulmonary Valve Endocarditis

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Hatamizadeh

    2009-06-01

    Full Text Available Infective endocarditis is one of the most severe complications of parenteral drug abuse. The outstanding clinical feature of infective endocarditis in intravenous drug abusers is the high incidence of right-sided valve infection, and the tricuspid valve is involved in 60% to 70% of the cases. We herein report a case of isolated pulmonic valve infective endocarditis with a native pulmonary valve.

  19. Transcatheter Pulmonary Valve Replacement

    OpenAIRE

    Ghawi, Hani; Kenny, Damien; Hijazi, Ziyad M.

    2012-01-01

    Transcatheter pulmonary valve replacement (tPVR) has evolved into a viable alternative to surgical conduit or bioprosthetic valve replacement. This procedure has paved the way for a more advanced approach to congenital and structural interventional cardiology. Although many successes have been noted, there are still a number of challenges with this procedure, including large delivery systems, the need for a conduit or a bioprosthetic valve as a landing zone for the valve, optimal timing of th...

  20. Consideraciones hidrogeoquímicas sobre el acuífero detrítico costero de Bou Ahmed (Marruecos)

    OpenAIRE

    El Attar, Aida; El Morabiti, Karim; Molina, Luis; Sánchez Martos, Francisco; El Kharim, Younes

    2009-01-01

    The salinity of the waters of the detritic aquifer of Bou Ahmed (Morocco) is very diverse. Based on their hydrogeochemistry, two types of water have been differentiated. The less saline group of waters (electrical conductivity less than 1.500 μS/cm) is directly related to the surface waters of the two rivers that feed the aquifer. The more saline group (1.000 μS/cm - 3.900 μS/cm) corresponds to sampling points along the valley sides. Their greater salinity is a consequence of the ...

  1. Experimental Contact Lens to Prevent Glaucoma-Induced Blindness

    Science.gov (United States)

    ... An Experimental Contact Lens to Prevent Glaucoma-Induced Blindness By Sharon Reynolds Posted January 23, 2014 An ... group of conditions that can result in irreversible blindness. This vision loss can be reduced if glaucoma ...

  2. Study Finds a Connection between Glaucoma and Sleep Apnea

    Science.gov (United States)

    ... an Ophthalmologist Patient Stories Español Eye Health / News Study Finds a Connection Between Glaucoma and Sleep Apnea Sep. 06, 2013 Over the years, several studies have demonstrated an increased rate of glaucoma among ...

  3. Heart Valve Diseases

    Science.gov (United States)

    Your heart has four valves. Normally, these valves open to let blood flow through or out of your heart, and then shut to keep it from flowing ... close tightly. It's one of the most common heart valve conditions. Sometimes it causes regurgitation. Stenosis - when ...

  4. A remote control valve

    International Nuclear Information System (INIS)

    This invention concerns a remote control valve for shutting off or distributing a fluid flowing at a high rate and low pressure. Among the different valves at present in use, electric valves are the most recommended for remote control but their reliability is uncertain and they soon become costly when large diameter valves are used. The valve described in this invention does away with this drawback owing to its simplicity and the small number of moving parts, this makes it particularly reliable. It mainly includes: a tubular body fitted with at least one side opening; at least one valve wedge for this opening, coaxial with the body, and mobile; a mobile piston integral with this wedge. Several valves to the specifications of this invention can be fitted in series (a shut-off valve can be used in conjunction with one or more distribution valves). The fitting and maintenance of the valve is very simple owing to its design. It can be fabricated in any material such as metals, alloys, plastics and concrete. The structure of the valve prevents the flowing fluid from coming into contact with the outside environment, thereby making it particularly suitable in the handling of dangerous or corrosive fluids. Finally, the opening and shutting of the valve occurs slowly, thereby doing away with the water hammer effect so frequent in large bore pipes

  5. Dynamic contour tonometry in asymmetric glaucoma patients

    Directory of Open Access Journals (Sweden)

    Parchen MAR

    2012-04-01

    Full Text Available Emilio Rintaro Suzuki Jr1, Cibele Lima Belico Suzuki1, Danielle Carlier1, Daniele Penha1, Marta dos Anjos Rodrigues Parchen1, Wagner Duarte Batista1, Joao Agostini Netto21Glaucoma Service, 2Department of Ophthalmology, Santa Casa de Belo Horizonte, MG, BrazilBackground: The purpose of this study was to determine any difference in dynamic contour tonometry and ocular pulse amplitude in asymmetric glaucoma patients with the same applanation intraocular pressure.Methods: This is a prospective, observational study of 30 glaucoma patients and 11 controls from June 2007 to February 2008. Most of the glaucoma patients were on prostaglandin analog treatment.Results: Mean applanation intraocular pressure in the control group was 14.28 mmHg for the right eye and 14.10 mmHg for the left eye (P > 0.05. Corneal thickness was 519.10 µm for the right eye and 511.07 µm for the left eye (P > 0.05. Mean dynamic contour tonometry intraocular pressure was 17.28 mmHg for the right eye and 17.25 mmHg for the left eye (P > 0.05. Mean ocular pulse amplitude was 2.80 mmHg for the right eye and 2.92 mmHg for the left eye (P > 0.05.Conclusion: No differences in ocular pulse amplitude were found between the two groups and between the worst and the best eye. In spite of there being no difference in ocular pulse amplitude, dynamic contour tonometry intraocular pressure was 2.44 mmHg higher in the worst eye than in the best eye in the glaucoma patients, even with the same applanation intraocular pressure. Further studies are needed to confirm if this difference is related to glaucoma progression or a worst prognosis and whether it can be considered to be a new risk factor.Keywords: dynamic contour tonometry, central cornea thickness, assymetric glaucoma

  6. Optic disc parameters in manifest and suspected glaucoma

    OpenAIRE

    Lene Martin; Lucian Vancea; Peter Wanger

    2011-01-01

    Structure and function measurements are important in glaucoma management. Digital fundus photography has become a standard procedure and the Heidelberg Retina Tomograph (HRT), commonly used by glaucoma specialists, provides a glaucoma probability score (GPS). The visual field index (VFI) is a novel statistic, aiming to facilitate follow-up of glaucoma patients. The aim of this study was to compare the results from the digital analysis of fundus photographs with HRT measurements including GPS ...

  7. Modern Technologies of Open-Angle Glaucoma Surgery

    OpenAIRE

    2014-01-01

    Currently, glaucoma surgery has become a major technique. Surgery is a method of choice in open-angle glaucoma, especially in those cases when conservative and laser treatments have no effect, as well as if glaucoma is inaccessible or a patient has low treatment compliance. In this review the authors give the information about the development of main glaucoma surgery directions, such as removal of pupillary block, the anterior chamber fistulization, the reduction of intraocular fluid producti...

  8. Association between Myopia and Glaucoma in the United States Population

    OpenAIRE

    Qiu, Mary; Wang, Sophia Y.; Singh, Kuldev; Lin, Shan C

    2013-01-01

    This study found an association between myopia and visual field defects, which may represent an increased risk of glaucoma among myopes, and the lack of association between myopia and self-reported glaucoma may suggest a need for greater glaucoma surveillance in this population.

  9. Respiratory exposure control valve

    International Nuclear Information System (INIS)

    We have designed a new, three-way valve that separates inhaled and exhaled air in systems for inhalation exposure. A single-channel model of the valve was constructed and tested: with a control fluid pressure of 10 psi, the valve was cycled 36,000 times without diaphragm failure. No valve leakage was detected before or after the completion of the test. A 3-channel valve model was constructed this year and will undergo testing in FY 1979, followed by development and testing of the control system

  10. MicroRNA target prediction in glaucoma.

    Science.gov (United States)

    Romano, Giovanni Luca; Platania, Chiara Bianca Maria; Forte, Stefano; Salomone, Salvatore; Drago, Filippo; Bucolo, Claudio

    2015-01-01

    Glaucoma is a progressive optic neuropathy and is one of the leading causes of blindness in the industrialized countries. The aim of this study is to investigate microRNA (miRNA) regulation in glaucoma and other neurodegenerative diseases, that share similar pathways, by means of in silico approaches such as bibliographic search and access to bioinformatic resources. First of all, data mining was carried out on Human miRNA Disease Database (HMDD) and miR2Disease databases. Then, predictions of deregulated miRNAs were carried out accessing to microrna.org database. Finally, the potential combinatorial effect of miRNAs, on regulation of biochemical pathways, was studied by an enrichment analysis performed by DIANA-miRPath v.2.0. We found, from literature search, 8 deregulated miRNAs in glaucoma and 9 and 23 in age-related macular degeneration (AMD) and Alzheimer's disease (AD), respectively. One miRNA is commonly deregulated in glaucoma and AMD (miR-23a). Two miRNAs (miR-29a, miR-29b) are common to glaucoma and AD, and four miRNAs were identified to be commonly deregulated in AMD and AD (miR-9, miR-21, miR-34a, miR-146a). The match of the miRNA common to glaucoma and the other two neurodegenerative diseases (AMD and AD) did not generate any output. Enrichment of information has been reached through miRNAs prediction: 88 predicted miRNAs are common to glaucoma and AMD, 19 are common to glaucoma and AD, and 9 are common to AMD and AD. Indeed, predicted miRNAs common to the three neurodegenerative diseases are nine (miR-107, miR-137, miR-146a, miR-181c, miR-197, miR-21, miR-22, miR-590, miR-9). DIANA-miRPath predicted that those nine miRNAs might regulate pathways involved in inflammation. The findings hereby obtained provide a valuable hint to assess deregulation of specific miRNA, as potential biomarkers and therapeutic targets, in glaucoma and other neurodegenerative diseases by means of preclinical and clinical studies. PMID:26497793

  11. Relief valve testing study

    International Nuclear Information System (INIS)

    Reclosing pressure-actuated valves, commonly called relief valves, are designed to relieve system pressure once it reaches the set point of the valve. They generally operate either proportional to the differential between their set pressure and the system pressure (gradual lift) or by rapidly opening fully when the set pressure is reached (pop action). A pop action valve allows the maximum fluid flow through the valve when the set pressure is reached. A gradual lift valve allows fluid flow in proportion to how much the system pressure has exceeded the set pressure of the valve (in the case of pressure relief) or has decreased below the set pressure (vacuum relief). These valves are used to protect systems from over and under pressurization. They are used on boilers, pressure vessels, piping systems and vacuum systems to prevent catastrophic failures of these systems, which can happen if they are under or over pressurized beyond the material tolerances. The construction of these valves ranges from extreme precision of less than a psi tolerance and a very short lifetime to extremely robust construction such as those used on historic railroad steam engines that are designed operate many times a day without changing their set pressure when the engines are operating. Relief valves can be designed to be immune to the effects of back pressure or to be vulnerable to it. Which type of valve to use depends upon the design requirements of the system

  12. Main Oxidizer Valve Design

    Science.gov (United States)

    Addona, Brad; Eddleman, David

    2015-01-01

    A developmental Main Oxidizer Valve (MOV) was designed by NASA-MSFC using additive manufacturing processes. The MOV is a pneumatically actuated poppet valve to control the flow of liquid oxygen to an engine's injector. A compression spring is used to return the valve to the closed state when pneumatic pressure is removed from the valve. The valve internal parts are cylindrical in shape, which lends itself to traditional lathe and milling operations. However, the valve body represents a complicated shape and contains the majority of the mass of the valve. Additive manufacturing techniques were used to produce a part that optimized mass and allowed for design features not practical with traditional machining processes.

  13. A new futuristic glaucoma therapeutic management paradigm

    Directory of Open Access Journals (Sweden)

    Anusuya Gehlot

    2015-04-01

    Full Text Available Glaucoma is a group of diseases, characterized by a progressive form of optic nerve damage. Current studies indicate more selective pathophysiological involvement, thereby targeted therapies are warranted. Although both the prostaglandin analogs and beta blockers are still, most commonly used drugs for glaucoma, due to their efficacy, lack of adverse effects. In addition, a stepped care approach is the corner stone for its management. In addition, attempts have been made to enhance patient compliance and ocular delivery of already available anti-glaucoma drugs such as pilocarpine and timolol maleate. Notable among futuristic treatment options are; novel delivery systems, benzalkonium chloride-free drugs, various glaucoma drainage devices, new targeted therapies and prompt diagnosis plus aggressive treatment, in patients with primary angle closure glaucoma. Promising new focus on vision sparing, greater patient safety and tolerability will provide improved treatment options and long-term preservation of vision and quality of life. [Int J Basic Clin Pharmacol 2015; 4(2.000: 195-197

  14. Topical glaucoma therapy cost in Mexico.

    Science.gov (United States)

    Lazcano-Gomez, Gabriel; Hernandez-Oteyza, Alejandra; Iriarte-Barbosa, María José; Hernandez-Garciadiego, Carlos

    2014-04-01

    Glaucoma is an important cause of irreversible blindness that represents a significant economic burden; most direct costs of glaucoma are drug-related. We calculated the annual cost of some of the most commonly prescribed glaucoma medications in Mexico, according to their average wholesale price (AWP) and dose regimen. Annual costs ranged from USD4.97 for Imot 15 ml (timolol 0.5 %; Laboratorios Sophia) to USD675.39 for Alphagan 5 ml (brimonidine 0.2 %; Allergan, Inc.). β-Blockers were the least expensive glaucoma medications (range USD20.44-55.44). Alphagan 5 ml was 250 % more expensive than other selective α(2)-agonists. Of the carbonic anhydrase inhibitors, dorzolamide 2 % was less expensive than brinzolamide 1 % (USD326.91 vs. USD418.96). The annual cost for prostaglandin analogs ranged from USD235.58 for bimatoprost 0.03 % to USD337.78 for latanoprost 0.005 %. Some fixed combinations were less expensive than separate combinations. The average annual cost for all treatments increased by 27.87 ± 10.09 % between 2009 and 2012. Annual glaucoma therapy cost seems to be lower in Mexico than in other countries, due to a lower AWP, especially for some medications made by Mexican laboratories. PMID:23846765

  15. Combating automative engine valve recession

    OpenAIRE

    Lewis, R; Dwyer-Joyce, R.S.

    2003-01-01

    [INTRODUCTION] Valve recession occurs when wear of the valve or seat inserts in an automotive engine has caused the valve to sink or recede into the seat insert (as shown in Figure 1). Excessive recession leads to valves not seating correctly and cylinder pressure loss. Leaking hot combustion gases can also cause valve guttering or torching, which will accelerate valve failure. Although new valve materials and production techniques are constantly being developed, these advances h...

  16. Endophthalmitis associated with Glaucoma Shunt Intraluminal Stent Exposure

    Science.gov (United States)

    Kerr, Nathan M; Ruddle, Jonathan B; Ang, Ghee Soon

    2016-01-01

    ABSTRACT Endophthalmitis post glaucoma drainage implant (GDI) surgery is rare, often associated with tube or plate exposure. We report a case of endophthalmitis following glaucoma shunt intraluminal stent exposure in a patient who underwent Baerveldt glaucoma implant surgery. Endophthalmitis following manipulation of intraluminal stents is a rare complication of GDIs but potentially vision threatening condition that needs to be carefully screened for and treated immediately. How to cite this article: Kwon HJ, Kerr NM, Ruddle JB, Ang GS. Endophthalmitis associated with Glaucoma Shunt Intraluminal Stent Exposure. J Curr Glaucoma Pract 2016;10(1):36-37.

  17. Current concepts in the pathophysiology of glaucoma.

    Science.gov (United States)

    Agarwal, Renu; Gupta, Suresh K; Agarwal, Puneet; Saxena, Rohit; Agrawal, Shyam S

    2009-01-01

    Glaucoma, the second leading cause of blindness, is characterized by changes in the optic disc and visual field defects. The elevated intraocular pressure was considered the prime factor responsible for the glaucomatous optic neuropathy involving death of retinal ganglion cells and their axons. Extensive investigations into the pathophysiology of glaucoma now reveal the role of multiple factors in the development of retinal ganglion cell death. A better understanding of the pathophysiological mechanisms involved in the onset and progression of glaucomatous optic neuropathy is crucial in the development of better therapeutic options. This review is an effort to summarize the current concepts in the pathophysiology of glaucoma so that newer therapeutic targets can be recognized. The literature available in the National Medical Library and online Pubmed search engine was used for literature review. PMID:19574692

  18. Glaucoma and obstructive sleep apnoea syndrome.

    Science.gov (United States)

    Faridi, Omar; Park, Sung Chul; Liebmann, Jeffrey M; Ritch, Robert

    2012-01-01

    Glaucoma is increasingly recognized as a manifestation of both ocular and systemic risk factors. A number of disorders associated with reduced blood flow and ischaemia, collectively termed vascular risk factors, such as migraine, Raynaud's phenomenon, atrial fibrillation and reduced nocturnal blood pressure, lead to decreased ocular perfusion pressure. During sleep, alterations occur in cardiovascular physiology that are balanced by autoregulation to maintain homeostasis. However, in obstructive sleep apnoea (OSA), the normal physiological balance is upset. A potentially modifiable risk factor, OSA has been increasingly associated with glaucoma independent of intraocular pressure. OSA may alter blood flow to the optic nerve head and, in combination with other predisposing factors, lead to decreased ocular perfusion pressure. This in turn may directly affect the optic nerve or it may indirectly increase its susceptibility to other insults. The purpose of this review is to shed light on the association between OSA and glaucoma. PMID:22339817

  19. Current concepts in the pathophysiology of glaucoma

    Directory of Open Access Journals (Sweden)

    Agarwal Renu

    2009-01-01

    Full Text Available Glaucoma, the second leading cause of blindness, is characterized by changes in the optic disc and visual field defects. The elevated intraocular pressure was considered the prime factor responsible for the glaucomatous optic neuropathy involving death of retinal ganglion cells and their axons. Extensive investigations into the pathophysiology of glaucoma now reveal the role of multiple factors in the development of retinal ganglion cell death. A better understanding of the pathophysiological mechanisms involved in the onset and progression of glaucomatous optic neuropathy is crucial in the development of better therapeutic options. This review is an effort to summarize the current concepts in the pathophysiology of glaucoma so that newer therapeutic targets can be recognized. The literature available in the National Medical Library and online Pubmed search engine was used for literature review.

  20. BILATERAL STEROID INDUCED GLAUCOMA IN VERNAL KERATOCONJUNCTIVITIS

    Directory of Open Access Journals (Sweden)

    Bangal Surekha V, Bankar Mahima S, Bhandari Akshay J, Kalkote Prasad R

    2015-01-01

    Full Text Available Vernal Keratoconjunctivits (VKC is a bilateral recurrent allergic interstitial conjunctival inflammation with a periodic seasonal incidence and of self limiting nature, mainly affecting the younger population. Patients of VKC on steroid therapy are at higher risk of developing steroid induced glaucoma. Raised intraocular pressure due to steroids typically occurs within few weeks of starting steroid therapy and comes back to normal on immediate stoppage of steroids. A case of steroid induced glaucoma in a 30 years old female with vernal keratoconjunctivitis. She was on topical steroids for 3-4 years. She was incompliant with the instructions to stop steroids. She eventually developed steroid induced glaucoma and glaucomatous optic neuropathy with tunnel vision.

  1. Patient education in glaucoma: what do patients know about glaucoma? Educação de pacientes sobre glaucoma: o que os pacientes sabem sobre glaucoma?

    Directory of Open Access Journals (Sweden)

    Vital Paulino Costa

    2006-12-01

    Full Text Available PURPOSE: To evaluate the knowledge glaucoma patients have about their disease and its treatment. METHODS: One hundred and eighty-three patients were interviewed at the Glaucoma Service of Wills Eye Hospital (Philadelphia, USA, Group 1 and 100 at the Glaucoma Service of University of Campinas (Campinas, Brazil, Group 2. An informal, relaxed atmosphere was created by the interviewer before asking a list of 18 open-ended questions. RESULTS: In Group 1, 44% of the 183 patients did not have an acceptable idea about what glaucoma is, 30% did not know the purpose of the medications they were taking, 47% were not aware of what was an average intraocular pressure, and 45% did not understand why visual fields were examined. In Group 2, 54% gave unsatisfactory answers to the question "What is glaucoma?", 54% did not know the purpose of the medications they were taking, 80% were not aware of what was an average intraocular pressure, and 94% did not understand why visual fields were examined (pOBJETIVO: Avaliar o conhecimento de pacientes glaucomatosos sobre sua doença e tratamento. MÉTODOS: 183 pacientes foram entrevistados no Serviço de Glaucoma do Wills Eye Hospital (Philadelphia, EUA, Grupo 1 e 100 pacientes foram entrevistados no Setor de Glaucoma da UNICAMP (Grupo 2. Dezoito perguntas abertas foram feitas aos pacientes num ambiente informal. RESULTADOS: No Grupo 1, 44% dos 183 pacientes não tinham conceito adequado sobre o que é glaucoma, 30% desconheciam porque usavam medicações, 47% não sabiam valores de pressão intra-ocular considerados normais e 45% não sabiam porque campos visuais eram testados. No Grupo 2, 54% responderam inadequadamente à pergunta "O que é glaucoma?", 54% desconheciam porque usavam medicações, 80% não sabiam valores de pressão intra-ocular considerados normais e 94% não sabiam porque campos visuais eram testados (p<0,001. Análise de regressão linear demonstrou que o nível de educação estava positivamente

  2. Glaucoma Detection From Fundus Image Using Opencv

    Directory of Open Access Journals (Sweden)

    K. Narasimhan

    2012-12-01

    Full Text Available This study proposes a semi automated method for glaucoma detection using CDR and ISNT ratio of a fundus image. CDR (Cup to Disc Ratio is ratio of area of Optic Cup to area of Optic Disc. For a patient with glaucoma Optic Cup size increases while the Optic Disc size remains same and hence CDR will be high for glaucoma patient than normal fundus image. The ROI of green plane is taken and K-Means clustering technique is recursively applied and Optic Disc and Optic Cup is segmented. Through elliptic fiiting, area of Optic Disc and Cup is determined and hence CDR is calculated. ISNT is another parameter used for the diagnosis of glaucoma which is determined through the ratio of area of blood vessels in Inferior Superior to Nasal Temporal side. Blood vessels will shift to Nasal side for glaucoma patients, hence value will be less for glaucoma patient than normal fundus image. Matched filter and Local entropy thresholding is applied to extract blood vessels. The code is programmed in C++ using OpenCV library functions. OpenCV (Open Source Computer Vision Library is a library of programming functions developed by Intel. Core, highgui, imgproc, ml are the main libraries used from OpenCV. The optimized functions in OpenCV increase the speed of operation and is very much suitable for real time mass screening purpose. A batch of 50 retinal images (25 normal set and 25 abnormal set obtained from the Aravind Eye Hospital, is used to assess the performance of the proposed system.

  3. Glaucoma alters the circadian timing system.

    Science.gov (United States)

    Drouyer, Elise; Dkhissi-Benyahya, Ouria; Chiquet, Christophe; WoldeMussie, Elizabeth; Ruiz, Guadalupe; Wheeler, Larry A; Denis, Philippe; Cooper, Howard M

    2008-01-01

    Glaucoma is a widespread ocular disease and major cause of blindness characterized by progressive, irreversible damage of the optic nerve. Although the degenerative loss of retinal ganglion cells (RGC) and visual deficits associated with glaucoma have been extensively studied, we hypothesize that glaucoma will also lead to alteration of the circadian timing system. Circadian and non-visual responses to light are mediated by a specialized subset of melanopsin expressing RGCs that provide photic input to mammalian endogenous clock in the suprachiasmatic nucleus (SCN). In order to explore the molecular, anatomical and functional consequences of glaucoma we used a rodent model of chronic ocular hypertension, a primary causal factor of the pathology. Quantitative analysis of retinal projections using sensitive anterograde tracing demonstrates a significant reduction (approximately 50-70%) of RGC axon terminals in all visual and non-visual structures and notably in the SCN. The capacity of glaucomatous rats to entrain to light was challenged by exposure to successive shifts of the light dark (LD) cycle associated with step-wise decreases in light intensity. Although glaucomatous rats are able to entrain their locomotor activity to the LD cycle at all light levels, they require more time to re-adjust to a shifted LD cycle and show significantly greater variability in activity onsets in comparison with normal rats. Quantitative PCR reveals the novel finding that melanopsin as well as rod and cone opsin mRNAs are significantly reduced in glaucomatous retinas. Our findings demonstrate that glaucoma impacts on all these aspects of the circadian timing system. In light of these results, the classical view of glaucoma as pathology unique to the visual system should be extended to include anatomical and functional alterations of the circadian timing system. PMID:19079596

  4. Glaucoma Alters the Circadian Timing System

    Science.gov (United States)

    Drouyer, Elise; Dkhissi-Benyahya, Ouria; Chiquet, Christophe; WoldeMussie, Elizabeth; Ruiz, Guadalupe; Wheeler, Larry A.; Denis, Philippe; Cooper, Howard M.

    2008-01-01

    Glaucoma is a widespread ocular disease and major cause of blindness characterized by progressive, irreversible damage of the optic nerve. Although the degenerative loss of retinal ganglion cells (RGC) and visual deficits associated with glaucoma have been extensively studied, we hypothesize that glaucoma will also lead to alteration of the circadian timing system. Circadian and non-visual responses to light are mediated by a specialized subset of melanopsin expressing RGCs that provide photic input to mammalian endogenous clock in the suprachiasmatic nucleus (SCN). In order to explore the molecular, anatomical and functional consequences of glaucoma we used a rodent model of chronic ocular hypertension, a primary causal factor of the pathology. Quantitative analysis of retinal projections using sensitive anterograde tracing demonstrates a significant reduction (∼50–70%) of RGC axon terminals in all visual and non-visual structures and notably in the SCN. The capacity of glaucomatous rats to entrain to light was challenged by exposure to successive shifts of the light dark (LD) cycle associated with step-wise decreases in light intensity. Although glaucomatous rats are able to entrain their locomotor activity to the LD cycle at all light levels, they require more time to re-adjust to a shifted LD cycle and show significantly greater variability in activity onsets in comparison with normal rats. Quantitative PCR reveals the novel finding that melanopsin as well as rod and cone opsin mRNAs are significantly reduced in glaucomatous retinas. Our findings demonstrate that glaucoma impacts on all these aspects of the circadian timing system. In light of these results, the classical view of glaucoma as pathology unique to the visual system should be extended to include anatomical and functional alterations of the circadian timing system. PMID:19079596

  5. Definition, Classification, and Pathophysiology of Canine Glaucoma.

    Science.gov (United States)

    Pizzirani, Stefano

    2015-11-01

    Glaucoma is a common ocular condition in humans and dogs leading to optic nerve degeneration and irreversible blindness. Primary glaucoma is a group of spontaneous heterogeneous diseases. Multiple factors are involved in its pathogenesis and these factors vary across human ethnic groups and canine breeds, so the clinical phenotypes are numerous and their classification can be challenging and remain superficial. Aging and oxidative stress are major triggers for the manifestation of disease. Multiple, intertwined inflammatory and biochemical cascades eventually alter cellular and extracellular physiology in the optic nerve and trabecular meshwork and lead to vision loss. PMID:26456751

  6. Patients and glaucoma: what are the challenges?

    Directory of Open Access Journals (Sweden)

    Mohammed Abdull, Fatima Kyari

    2012-01-01

    Full Text Available Mohammed Abdull is the head of the ophthalmology department at Abubakar Tafawa Balewa University Teaching hospital in Bauchi, Bauchi State, Nigeria, and is studying for a PhD at the International Centre for Eye Health, London School of Hygiene and Tropical Medicine. His field research, conducted in Bauchi, is aimed at understanding how people’s awareness of glaucoma relates to the severity of glaucoma they have when they arrive at the hospital as well as their ability to manage the disease. He spoke to Fatima Kyari.

  7. Force Augmentation for Relief Valve

    Science.gov (United States)

    Luger, J.

    1982-01-01

    Simple design change for poppet relief valve enables flow through valve to exert additional force to help keep valve open. Although originally intended for relief valves for liquid oxygen and liquid nitrogen in Space Shuttle orbiter, concept is applicable to pressure-or flow-actuated valves for wide range of fluids and temperatures.

  8. Automatic rotary valve actuator

    International Nuclear Information System (INIS)

    This report describes the design, construction, and operation of a microcomputer-controlled valve actuator for operating test valves requiring rotary motion of the valve stem. An AIM 65 microcomputer, using a FORTH language program, controls an air motor and air clutch mounted within an oven to accomplish testing at elevated temperatures. The valve actuator closes the test valve until a preset torque is reached and then opens the valve to its initial starting point. The number of cycles and extremes of rotation are tallied and printed as the test progresses. Provisions are made to accept remote signals to stop the test and to indicate to a remote device when the test has been stopped

  9. JenaValve.

    Science.gov (United States)

    Treede, Hendrik; Rastan, Ardawan; Ferrari, Markus; Ensminger, Stephan; Figulla, Hans-Reiner; Mohr, Friedrich-Wilhelm

    2012-09-01

    The JenaValve is a next-generation TAVI device which consists of a well-proven porcine root valve mounted on a low-profile nitinol stent. Feeler guided positioning and clip fixation on the diseased leaflets allow for anatomically correct implantation of the device without rapid pacing. Safety and efficacy of transapical aortic valve implantation using the JenaValve were evaluated in a multicentre prospective study that showed good short and midterm results. The valve was CE-mark released in Europe in September 2011. A post-market registry ensures on-going and prospective data collection in "real-world" patients. The transfemoral JenaValve delivery system will be evaluated in a first-in-man study in the near future. PMID:22995119

  10. Low noise control valve

    International Nuclear Information System (INIS)

    Noise is one of the problems associated with the use of any type of control valve in systems involving the flow of fluids. The advent of OSHA standards has prompted control valve manufacturers to design valves with special trim to lower the sound pressure level to meet these standards. However, these levels are in some cases too high, particularly when a valve must be located in or near an area where people are working at tasks requiring a high degree of concentration. Such locations are found around and near research devices and in laboratory-office areas. This paper describes a type of fluid control device presently being used at PPL as a bypass control valve in deionized water systems and designed to reduce sound pressure levels considerably below OSHA standards. Details of the design and construction of this constant pressure drop variable flow control valve are contained in the text and are shown in photographs and drawings. Test data taken are included

  11. Dual valve plate two-way pressure relief valve

    Science.gov (United States)

    Angeli, Robert J.

    1994-02-01

    There is disclosed a two-way valve which includes dual valve plates to be positioned between first and second chambers having varying pressure therein, to relieve excess pressure in either chamber by permitting fluid flow from one chamber to the other. The valve includes a body portion having disposed therein dual valve plates. In the equilibrium state, the first valve plate is spring biased against the valve body in the direction of the first chamber to seal off any flow through the valve. The second valve plate is separately spring biased against the first valve plate in the direction of the second chamber, scaling off flow between the valve plates. When the pressure of the first chamber is greater than the pressure of the second chamber by a pre-determined amount, the first and second valve plates move away from the valve body permitting fluid flow from the first chamber to the second chamber.

  12. Association of Open-Angle Glaucoma Loci With Incident Glaucoma in the Blue Mountains Eye Study

    OpenAIRE

    Kathryn P Burdon; Mitchell, Paul; Lee, Anne; Healey, Paul R.; White, Andrew J R; Rochtchina, Elena; Thomas, Peter B.M.; Wang, Jie Jin; Craig, Jamie E

    2015-01-01

    Purpose To determine if open-angle glaucoma (OAG)-associated single nucleotide polymorphisms (SNPs) are associated with incident glaucoma and if such genetic information is useful in OAG risk prediction. Design Case-control from within a population-based longitudinal study. Methods study population : Individuals aged over 49 years of age living in the Blue Mountains region west of Sydney and enrolled in the Blue Mountains Eye Study. observation : Cases for this sub-study (n = 67) developed in...

  13. 飞秒化学的先驱者--记诺贝尔化学奖得主Ahmed H.Zewail教授%The Precursor of the Femtochemistry-Nobel Prize's Winner:Professor Ahmed H.Zewail

    Institute of Scientific and Technical Information of China (English)

    兰峥岗; 王鸿飞

    2000-01-01

    @@ 1999年10月12日,瑞典皇家科学院将今年的诺贝尔化学奖授予埃及和美国双重国籍的物理化学和化学物理学家Ahmed H.Zewail,以表彰他在利用飞秒激光脉冲研究化学反应方面的开拓性工作.各国科学家都认为这是一个众望所归的结果.在最近几年里,Zewail教授一直是诺贝尔化学奖呼声很高的候选人,并得到多次提名.

  14. [Modern mitral valve surgery].

    Science.gov (United States)

    Bothe, W; Beyersdorf, F

    2016-04-01

    At the beginning of the 20th century, Cutler and Levine performed the first successful surgical treatment of a stenotic mitral valve, which was the only treatable heart valve defect at that time. Mitral valve surgery has evolved significantly since then. The introduction of the heart-lung machine in 1954 not only reduced the surgical risk, but also allowed the treatment of different mitral valve pathologies. Nowadays, mitral valve insufficiency has become the most common underlying pathomechanism of mitral valve disease and can be classified into primary and secondary mitral insufficiency. Primary mitral valve insufficiency is mainly caused by alterations of the valve (leaflets and primary order chords) itself, whereas left ventricular dilatation leading to papillary muscle displacement and leaflet tethering via second order chords is the main underlying pathomechanism for secondary mitral valve regurgitation. Valve reconstruction using the "loop technique" plus annuloplasty is the surgical strategy of choice and normalizes life expectancy in patients with primary mitral regurgitation. In patients with secondary mitral regurgitation, implanting an annuloplasty is not superior to valve replacement and results in high rates of valve re-insufficiency (up to 30 % after 3 months) due to ongoing ventricular dilatation. In order to improve repair results in these patients, we add a novel subvalvular technique (ring-noose-string) to the annuloplasty that aims to prevent ongoing ventricular remodeling and re-insufficiency. In modern mitral surgery, a right lateral thoracotomy is the approach of choice with excellent repair and cosmetic results. PMID:26907868

  15. Heimlich valve and pneumothorax

    OpenAIRE

    Gogakos, Apostolos; Barbetakis, Nikolaos; Lazaridis, George; Papaiwannou, Antonis; Karavergou, Anastasia; Lampaki, Sofia; Baka, Sofia; Mpoukovinas, Ioannis; Karavasilis, Vasilis; Kioumis, Ioannis; Pitsiou, Georgia; Katsikogiannis, Nikolaos; Tsakiridis, Kosmas; Rapti, Aggeliki; Trakada, Georgia

    2015-01-01

    The Heimlich valve is a small one-way valve used for chest drainage that empties into a flexible collection device and prevents return of gases or fluids into the pleural space. The Heimlich valve is less than 13 cm (5 inches) long and facilitates patient ambulation. Currently there are several systems in the market. It can be used in many patients instead of a traditional water seal drainage system. The Heimlich chest drainage valve was developed so that the process of draining the pleural c...

  16. Butterfly valves for seawater

    International Nuclear Information System (INIS)

    Recently in thermal and nuclear power stations and chemical plants which have become large capacity, large quantity of cooling water is required, and mostly seawater is utilized. In these cooling water systems, considering thermal efficiency and economy, the pipings become complex, and various control functions are demanded. For the purpose, the installation of shut-off valves and control valves for pipings is necessary. The various types of valves have been employed, and in particular, butterfly valves have many merits in their function, size, structure, operation, maintenance, usable period, price and so on. The corrosion behavior of seawater is complicated due to the pollution of seawater, therefore, the environment of the valves used for seawater became severe. The structure and the features of the butterfly valves for seawater, the change of the structure of the butterfly valves for seawater and the checkup of the butterfly valves for seawater are reported. The corrosion of metallic materials is complicatedly different due to the locating condition of plants, the state of pipings and the condition of use. The corrosion countermeasures for butterfly valves must be examined from the synthetic viewpoints. (K.I.)

  17. Minimally Invasive Aortic Valve Replacement

    Medline Plus

    Full Text Available ... the primary reason that we end up offering patients aortic valve surgery in our community. Aortic stenosis ... a picture of the aortic valve from a patient who had a very diseased aortic valve. And ...

  18. Minimally Invasive Aortic Valve Replacement

    Medline Plus

    Full Text Available ... opens freely when the heart contracts. On the right, we see a picture of the aortic valve ... the aortic valve because the probe is sitting right behind the aortic valve. Lots of patients on ...

  19. Diabetic glaucoma: clinical and treatment features

    Directory of Open Access Journals (Sweden)

    D V Lipatov

    2011-03-01

    Full Text Available The purpose of the given work became an estimation of efficiency of drainage surgery and combined preparations at treatment secondary newvascular the complicated diabetic glaucoma at patients with a diabetes militus (DM. Material and methods. Results of 46 operations and 34 cases of conservative therapy by the combined preparations at patients with a diabetic glaucoma and a DM have been investigated. Results. At all patients in the postoperative period the painful syndrome has been stoped and proof reduction in intraocular pressure is received. In the early postoperative period there were following complications: gifema, cataract, reduction of depth of the forward chamber of an eye because of swelling a crystalline lens and detachment a vascular environment. In the late postoperative period “exposure” of a drainage tube, a vascular cataract and dystrophy of cornea were observed “capture” iris. More than in half of cases high preoperative intraocular pressure it was possible to compensate at use of combined preparation Коsopt (MSD, USA. Conclusions. The diabetic glaucoma objectively exists also drainage surgery there should be “the gold standard” treatments of this pathology and its complications at patients with a DM. Combined preparation Коsopt (MSD, USA has shown high efficiency in reduction in intraocular pressure at patients with a diabetic glaucoma and their preparations for scheduled surgical intervention.

  20. The Suprachoroidal Route in Glaucoma Surgery

    Science.gov (United States)

    Shaarawy, Tarek

    2016-01-01

    ABSTRACT Glaucoma surgeries targeting the uveoscleral drainage pathways have been drawing more attention lately. Among all the available techniques, procedures focusing on the supra-choroidal space seem particularly promising, by making use of a presumably efficient and secure outflow route and avoiding subconjunctival filtration blebs. The purpose of this review is to assess the efficacy and the security of the different suprachoroidal drainage implants, namely the CyPass Micro-Stent, the iStent Supra, the SOLX Gold Shunt, the Aquashunt, and the STARflo Glaucoma Implant. Most clinical studies seem to currently point toward the direction that there are actual benefits in suprachoroidal surgeries by avoiding bleb-related complications. Nevertheless, even suprachoroidal implants may be subject to scarring and failure. More data are still needed, especially concerning long-term effects, although the approach does seem appealing. How to cite this article: Gigon A, Shaarawy T. The Suprachoroidal Route in Glaucoma Surgery. J Curr Glaucoma Pract 2016;10(1): 13-20.

  1. Primary angle-closure glaucoma: an update.

    Science.gov (United States)

    Wright, Carrie; Tawfik, Mohammed A; Waisbourd, Michael; Katz, Leslie J

    2016-05-01

    Primary angle-closure glaucoma is potentially a devastating disease, responsible for half of glaucoma-related blindness worldwide. Angle closure is characterized by appositional approximation or contact between the iris and trabecular meshwork. It tends to develop in eyes with shallow anterior chambers, anteriorly positioned or pushed lenses, and angle crowding. Risk of primary angle-closure glaucoma is high among women, the elderly and the hyperopic, and it is most prevalent in Asia. Investigation into genetic mechanisms of glaucoma inheritance is underway. Diagnosis relies on gonioscopy and may be aided by anterior segment optical coherence tomography and ultrasound biomicroscopy. Treatment is designed to control intraocular pressure while monitoring changes to the angle and optic nerve head. Treatment typically begins with medical management through pressure-reducing topical medications. Peripheral iridotomy is often performed to alleviate pupillary block, while laser iridoplasty has been found effective for mechanisms of closure other than pupillary block, such as plateau iris syndrome. Phacoemulsification, with or without goniosynechialysis, both in eyes with existing cataracts and in those with clear lenses, is thus far a viable treatment alternative. Long-term research currently underway will examine its efficacy in cases of angle closure in early stages of the disease. Endoscopic cyclophotocoagulation is another treatment option, which can be combined with cataract surgery. Trabeculectomy remains effective therapy for more advanced cases. PMID:26119516

  2. A STYLISTIC ANALYSIS OF FAIZ AHMED FAIZ’S POEM SUBH-E-AZAADI (DAWN OF FREEDOM

    Directory of Open Access Journals (Sweden)

    Maratab Ali

    2015-03-01

    Full Text Available Stylistics is the study of style of literary genres of individual writer or poet which are particular to him. Such styles are studied through distinct linguistic choices which work as a bridge between linguistic tools and literary criticism. This paper aims to highlight the stylistic features of Faiz Ahmed Faiz's poem "Subh-e-Azadi 1947" (Dawn of Freedom.The lexical choices and style which the poet has adopted to highlight the main theme of his poem is critically analyzed. Step by step stylistic analysis revolves around five levels i.e. grammatical, phonetic, phonological, graph logical and lexical level. It will help readers to better understand the complex syntactical patterns and poetic devices used by the poet.

  3. The painting technique of the vaulted roof at the Saadian Tomb of Mulay Ahmed Al Mansour: preliminary results

    International Nuclear Information System (INIS)

    The Saadian tombs date back from the time of the sultan Ahmed Al Mansour (1578-1603). the tombs have, because of the beauty of their decoration, been a major attraction for visitors of Marrakech. The central mausoleum, the Hall of Twelve Columns, contains the tombs of ahmed Al Mansour and his family. It's dark, lavish, and ornate, with a huge vaulted roof, carved cedar doors and moucharabia (carved wooden screens traditionally to separate the sexes), and gray Italian marble columns. Samples from the painted roof have been collected and are currently under analysis to understand the executive technique used in its decoration. Generally, samples from painted works of art are characterised by the presence of several different organic materials together with pigments, fillers and dryers. A GC-MS analytical procedure for the characterisation of lipids, waxes, resins, pitch, tar, proteinaceous and polysaccharide material in the same paint micro-sample is applied to each collected micro-sample. The analytical procedure is based on a multi step sample pre-treatment that is able to separate the various organic components into different fractions (polysacharide, lipiresinous and proteinaceous), which are separately analyzed by GC-MS after purification and derivatisation. In particuler, this method achieves: -- the identification of proteinaceous binder (egg, collagen, casein) on the basis of the quantitative determination of the amino acid profile processed by principal component analysis -- the identification of lipids (linseed oil, poppy seed oil, walnut oil and egg), plant resins, animal resins,tar or pitches and natural waxes on the basis of the quantitative determination of fatty and dicarboxylic acids, and molecular pattern recognition of alchols and hydrocarbons and terpenic molecular markers -- the identification of th polysaccharide binder( starch, tragacanth gum, arabic gum, fruit tree gum, guar gum, karayagum) on the basis of the quantitative

  4. Avaliação dos tipos de glaucoma no serviço de oftalmologia da UNICAMP Evaluation of glaucoma types at the sector of ophthalmology - UNICAMP

    Directory of Open Access Journals (Sweden)

    Andréia Peltier Urbano

    2003-01-01

    Full Text Available OBJETIVO: Avaliar a freqüência dos tipos de glaucoma no Setor de Glaucoma do Hospital das Clínicas da Universidade Estadual de Campinas. MÉTODOS: Estudo transversal de 329 pacientes atendidos no Setor de Glaucoma da Universidade Estadual de Campinas entre 1 de outubro e 20 de dezembro de 2000, com avaliação dos tipos de glaucoma e conduta terapêutica. RESULTADOS: De 329 pacientes atendidos no Ambulatório de Glaucoma, 132 foram encaminhados ao ambulatório por suspeita de glaucoma (40,1% e 197 como glaucoma diagnosticado (59,9%. Dos 132 suspeitos de glaucoma, 90 (68,2% foram confirmados como tendo glaucoma e 42 (31,8% encontram-se em acompanhamento. Dos 329 pacientes avaliados, 283 (86% tinham glaucoma, 42 (12,8% suspeita de glaucoma, 2 (0,6% diagnóstico de glaucoma excluído e 2 (0,6% hipertensão ocular. Dos 530 olhos glaucomatosos, havia 298 (56,2% glaucomas primários de ângulo aberto, 108 (20,4% glaucomas primários de ângulo estreito, 21 (4% glaucomas pós-facectomia, 19 (3,6% glaucomas congênitos e 16 (3% glaucomas de pressão normal. A conduta terapêutica adotada foi inicialmente clínica em todos os casos. Após seguimento médio de 10,5 meses, 89 (16,8% olhos necessitaram tratamento com laser: 72 (13,6% iridotomias, 7 (1,3% trabeculoplastias e 10 (1,9% panfotocoagulações. Cento e setenta e cinco olhos (33% foram submetidos a tratamento cirúrgico. CONCLUSÃO: O tipo mais freqüente de glaucoma observado foi o glaucoma primário de ângulo aberto, seguido por glaucoma primário de ângulo estreito. Glaucomas como o de pressão normal e o pseudo-exfoliativo foram pouco freqüentes na população estudada.PURPOSE: To evaluate the frequency of different types of glaucoma at the Hospital das Clínicas of Campinas State University. METHODS: Cross-sectional study of 329 patients followed at the Glaucoma Service of Campinas State University from October 1 to December 20, 2000. The frequency of each type of glaucoma and the

  5. A New Provocative Test for Glaucoma

    Science.gov (United States)

    Moreira, TCA; Campos, LF; Vianello, MP; Corradi, J; Dorairaj, SK; Freitas, ALA; Ritch, R

    2016-01-01

    ABSTRACT Purpose: To compare the effects of the water-drinking test (WDT) with the 30° inverted body position test on intraocular pressure (IOP) in normal patients, suspected glaucoma patients and glaucoma patients. Materials and methods: Based on clinical evaluation of the optic disk, IOP, and standard achromatic perimetry (SAP) of 71 eyes, 18 were “normal” (normal SAP and optic disk evaluation, and IOP 0.5 or asymmetry > 0.2 and/or ocular hypertension), and 31 had “early glaucoma” (MD < -6 dB, glaucomatous optic neuropathy). Standard achromatic perimetry was performed with the Octopus 3.1.1 Dynamic 24-2 program. Patients fasted before the WDT, and four measurements were performed at basal, 15’, 30, and 45’ after drinking 1 liter of water (WDT) in 5 minutes. In the 30° inverted position, IOP measurement with Perkins applanation tonometer was taken after 5 minutes lying down. Results: There was a statistical difference in all groups between the basal IOP and peak IOP during the WDT (p < 0.001) and in the inverted position IOP (p < 0.001). Controls (p = 0.50), suspects (p = 0.41) and glaucoma patients (p = 1.0) did not exhibit a difference between WDT-IOP and inverted position IOP. Conclusion: The 30° inverted position test was as efficient as WDT in detecting peak IOP. This new provocative test is easier, faster and more comfortable for both patients and doctors. How to cite this article: Kanadani FN, Moreira TCA, Campos LF, Vianello MP, Corradi J, Dorairaj SK, Freitas ALA, Ritch R. A New Provocative Test for Glaucoma. J Curr Glaucoma Pract 2016;10(1): 1-3. PMID:27231412

  6. Latanoprost in the treatment of glaucoma

    Directory of Open Access Journals (Sweden)

    Alm A

    2014-09-01

    Full Text Available Albert AlmDepartment of Neuroscience, Ophthalmology, University Hospital, Uppsala, SwedenAbstract: Prostaglandins are approved by the European Glaucoma Society guidelines as first-line treatment for glaucoma. This review focuses on latanoprost, an ester prodrug of prostaglandin (PG F2α, which was the first of the currently available topical PGF2α analogs to be launched for glaucoma or ocular hypertension and which still accounts for the majority of prescriptions. It is better absorbed than the parent compound through the cornea, and peak concentration of the active drug is in the aqueous humor 1–2 hours after topical dosing (15–30 ng/mL. Metabolism occurs mainly in the liver. Latanoprost (0.005% has been very well studied in clinical trials and meta-analyses that show it to be generally as effective as the other PG analogs (bimatoprost, travoprost, and tafluprost and more effective than timolol, dorzolamide, and brimonidine. Latanoprost has good short- and long-term safety and tolerability profiles. In common with other prostaglandins, it lacks systemic effects, but can cause ocular adverse events such as conjunctival hyperemia, pigmentation of the iris, periocular skin or eyelashes, hypertrichosis, and ocular surface effects or irritation. Latanoprost is significantly better tolerated than either bimatoprost or travoprost. Patients treated with latanoprost have better compliance and persist with therapy longer than those that are given other drugs. An improved formulation of latanoprost without the preservative benzalkonium chloride has recently been developed. It is as effective as conventional latanoprost, has a lower incidence of hyperemia, and can be stored at room temperature. In conclusion, latanoprost has the best efficacy–tolerability ratio of the PG analogs available for glaucoma treatment, and has good compliance and persistence. These factors should be improved further by the recent development of preservative

  7. Heimlich valve and pneumothorax.

    Science.gov (United States)

    Gogakos, Apostolos; Barbetakis, Nikolaos; Lazaridis, George; Papaiwannou, Antonis; Karavergou, Anastasia; Lampaki, Sofia; Baka, Sofia; Mpoukovinas, Ioannis; Karavasilis, Vasilis; Kioumis, Ioannis; Pitsiou, Georgia; Katsikogiannis, Nikolaos; Tsakiridis, Kosmas; Rapti, Aggeliki; Trakada, Georgia; Zissimopoulos, Athanasios; Tsirgogianni, Katerina; Zarogoulidis, Konstantinos; Zarogoulidis, Paul

    2015-03-01

    The Heimlich valve is a small one-way valve used for chest drainage that empties into a flexible collection device and prevents return of gases or fluids into the pleural space. The Heimlich valve is less than 13 cm (5 inches) long and facilitates patient ambulation. Currently there are several systems in the market. It can be used in many patients instead of a traditional water seal drainage system. The Heimlich chest drainage valve was developed so that the process of draining the pleural cavity could be accomplished in a safe, relatively simple, and efficient manner. This valve system has replaced the cumbersome underwater drainage bottle system. Moreover; the Heimlich valve system connects to chest tubing and allows fluid and air to pass in one direction only. This system functions in any position, and it does not ever need to be clamped, a regulated suction can be attached to it if necessary. The valve drains into a plastic bag that can be held at any level, allowing the patient undergoing chest drainage to be ambulatory simply by carrying the bag. In the current mini review we will present the Heimlich valve system and method of insertion. PMID:25861609

  8. Alternative therapy in glaucoma management: Is there any role?

    Directory of Open Access Journals (Sweden)

    Parikh Rajul

    2011-12-01

    Full Text Available Glaucoma is one of the leading causes of blindness worldwide. Various randomized controlled clinical trials have shown that lowering intraocular pressure (IOP does reduce progression of primary open-angle glaucoma. However, there is lots of interest in nonpharmacological options that includes lifestyle adjustment and alternative and complementary therapy (ACT. At least 5% glaucoma population uses ACT. Various lifestyle activities like exercise and alcohol can reduce IOP by 1 to 2 mm Hg but would have small effect on glaucoma. The psychological stress can increase IOP. Hypothetically and few studies do show neuroprotective effect (or effect on ocular blood flow of alcohol, Gingko biloba, bilberry, but the current evidence is weak for its routine use. We must also remember the side effects of ′medications′ (e.g., marijuana, alcohol before promoting as remedy for glaucoma. In current armamentarium of glaucoma management, ACT cannot substitute the conventional treatment available to lower IOP.

  9. The pedigree of a patient with juvenile glaucoma

    OpenAIRE

    DİLSİZ, Dr. Serdal ÇELEBİ Dr. Orhan AYDEMİR : D

    1999-01-01

    Purpose: The pedigree of nine year old patient diagnosed with juvenile glaucoma has been evaluated. Materials and Methods: The pedigree of seven members (close relatives of proband's from three generations) was investigated and then clinical examinations were performed. Their blood samp/es were analysed for chromosomes. Resu/ts: From this pedigree, it was found that, two cases had juvenile glaucoma, two cases had primary open angle glaucoma and two cases were suspected to have...

  10. A Congenital Glaucoma Case with Rubinstein-Taybi Syndrome

    OpenAIRE

    Mümin Hakan Eren; Hasan Alt›nkaynak; Hülya Güngel; Tan›l Gürsel

    2011-01-01

    To evaluate systemic/eye manifestations and treatment modalities in a case of Rubinstein-Taybi Syndrome (RTS) with bilateral congenital glaucoma and structural eye anomalies. Eight-month-old infant with RTS presented to our clinic with bilateral epiphora and corneal haze in one eye. In ophthalmologic examination, bilateral congenital glaucoma and epiblepharon were found. Medical and surgical treatments of congenital glaucoma were performed. Abnormal eye findings are commonly seen ...

  11. Optic Disc Hemorrhage after Phacoemulsification in Patients with Glaucoma

    OpenAIRE

    Bojikian, Karine D.; Daniel B. Moore; Chen, Philip P.; Slabaugh, Mark A.

    2014-01-01

    Background. Optic disk hemorrhage is known to be a risk factor for glaucoma progression. Cataract surgery by phacoemulsification results in large intraocular pressure fluctuations. We aim to investigate whether phacoemulsification is associated with optic disc hemorrhage in patients with glaucoma. Methods. This is a retrospective review of consecutive university clinic based glaucoma patients undergoing phacoemulsification alone, with at least 3 visits in the year before and at least 5 visits...

  12. Vascular Considerations in Glaucoma Patients of African and European Descent

    OpenAIRE

    Huck, Andrew; Harris, Alon; Siesky, Brent; Kim, Nathaniel; Muchnik, Michael; Kanakamedala, Priyanka; Amireskandari, Annahita; Tobe, Leslie Abrams

    2014-01-01

    Glaucoma is the leading cause of blindness in individuals of African descent (AD). While open angle glaucoma (OAG) disproportionately affects individuals of AD compared to persons of European descent (ED); the physiological mechanisms behind this disparity are largely unknown. The more rapid progression and greater severity of the disease in persons of AD further raises the concern for identifying these underlying differences in disease pathophysiology between AD and ED glaucoma patients. Ocu...

  13. Citalopram associated with acute angle-closure glaucoma: case report

    OpenAIRE

    Hassan Sabit; Thirumalai Srinivasa; Croos Robert; Davis Jane

    2005-01-01

    Abstract Background Acute angle-closure glaucoma is a rare complication in patients receiving anti-depressant treatment. In the following case, we report the development of acute angle closure glaucoma in a patient who overdosed on Citalopram, an antidepressant, and discuss the possible etiological mechanisms for the condition. Case presentation We report a 54 year old, Caucasian lady, with depression and alcohol dependence syndrome, who developed acute angle-closure glaucoma after an overdos...

  14. Contrast sensitivity and visual disability in chronic simple glaucoma

    OpenAIRE

    Ross, J E; Bron, A J; Clarke, D D

    1985-01-01

    A battery of vision tests was used to quantify visual defect in a group of 50 patients with chronic simple glaucoma. The vision tests were near and distance visual acuity, visual fields, and contrast sensitivity to static and temporally modulated sinusoidal grating patterns. Of these, static contrast sensitivity function appears to be the most sensitive method of measuring visual defect in glaucoma patients. The visual disability experienced by the glaucoma patients was quantified by means of...

  15. Cyclo-photocoagulation in the management of aphakic glaucoma

    International Nuclear Information System (INIS)

    Transpupillary argon laser photocoagulation of the ciliary processes (TALC) through a widely dilated pupil, with or without cerebral depression, has been used in the management of glaucoma in aphakic eyes for a number of years. 58% of glaucoma in aphakics treated with TALC showed sustained and meaningful intraocular pressure reduction 2 months to 5 years after the procedure. Clinically, the TALC procedure is a relatively safe, effective, and an useful alternative approach in the management of selected cases of glaucoma in aphakics. (Auth.)

  16. Angioid streaks - a rare cause of neovascular glaucoma. Case report.

    OpenAIRE

    Ungureanu, E; Geamanu, A; Careba, I; Grecescu, M; Gradinaru, S

    2014-01-01

    Rationale. Neovascular glaucoma is the type of glaucoma most refractory to treatment. The most frequent causes are those associated with retinal hypoxia, such as proliferative diabetic retinopathy, central retinal vein occlusion, branch retinal vein occlusion, central retinal arterial occlusion, ischemic ocular syndrome etc. Rare causes of neovascular glaucoma are multiple and are due to VEGF synthesis associated with chorioretinal inflammations or degenerations. We present a case with neovas...

  17. Evaluation of ExPress glaucoma filtration device in Indian patients with advanced glaucoma

    Directory of Open Access Journals (Sweden)

    Dewang Angmo

    2015-01-01

    Full Text Available ExPress glaucoma filtration device (GFD has recently become available in India as a surgical option for glaucoma patients. We retrospectively evaluated the outcome of ExPress GFD in 12 eyes with advanced glaucoma with intraocular pressures (IOPs not controlled on maximal tolerable medical therapy. The mean preoperative IOP of 29.58 ± 7.13 mmHg decreased to 17.0 ± 2.67 and 17.40 ± 0.89 mmHg at 6 and 12 months after surgery. Absolute success (IOP ≤ 18 mmHg, with no additional glaucoma medications was achieved in eight cases (66.7% and qualified success (IOP ≤ 18 mmHg, with additional glaucoma medications in two cases (16.7% at 1-year after surgery. Early intervention was needed in 4 patients; two underwent anterior chamber reformation while the other two required needling. Two patients required resurgery. There was no significant change in the best corrected visual acuity postoperatively (P = 0.37. ExPress GFD does not seem to offer a benefit over standard trabeculectomy in patients with advanced glaucomatous disease in terms of IOP control or complication rate. However, due to the small sample size with a heterogeneous mixture of primary and secondary glaucoma′s, we await further studies with a larger sample size and long-term follow-up, to see how the device performs.

  18. Prevalance study of glaucoma in Malta and Gozo

    OpenAIRE

    Cachia, John; Soler, Richard; Blagojevic, Milan; Agius Muscat, Hugo

    1992-01-01

    A glaucoma survey was carried out in Malta and Gozo. Using non-contact pulseair tonometer, 2245 participants selected on a random basis, aged 40 years and above, were examined and 3.29% were found to have glaucoma. Among them 1.69% were newly detected glaucoma cases. The main risk factors were diabetes mellitus in the personal past history and glaucoma in the family history. Age was confirmed to be a risk factor, but arterial hypertension and myopia could not be proved as risk factors. About ...

  19. Clinical evidence in concurrence of retinitis pigmentosa and glaucoma

    Institute of Scientific and Technical Information of China (English)

    WANG Mei; LIN Hao-tian; BAI Yu-jing; GE Jian; ZHUO Ye-hong

    2011-01-01

    Glaucoma is rarely complicated by retinitis pigmentosa (RP). To provide clinical evidences for this rare situation, we report the concurrence of these two diseases in two children of a Chinese family. In the present two-child Chinese family without positive history, the older sister presented with bilateral sector RP and coexisting chronic angle-closure glaucoma,and the brother with bilateral whole RP but without coexisting glaucoma. Clinical evidences in concurrence of variants of RP and glaucoma because of possible different gene mutations from the same genetic background represent a rare situation, which may provide clues for future researches in molecular pathogenesis of these rare diseases.

  20. Gate valve performance prediction

    International Nuclear Information System (INIS)

    The Electric Power Research Institute is carrying out a program to improve the performance prediction methods for motor-operated valves. As part of this program, an analytical method to predict the stem thrust required to stroke a gate valve has been developed and has been assessed against data from gate valve tests. The method accounts for the loads applied to the disc by fluid flow and for the detailed mechanical interaction of the stem, disc, guides, and seats. To support development of the method, two separate-effects test programs were carried out. One test program determined friction coefficients for contacts between gate valve parts by using material specimens in controlled environments. The other test program investigated the interaction of the stem, disc, guides, and seat using a special fixture with full-sized gate valve parts. The method has been assessed against flow-loop and in-plant test data. These tests include valve sizes from 3 to 18 in. and cover a considerable range of flow, temperature, and differential pressure. Stem thrust predictions for the method bound measured results. In some cases, the bounding predictions are substantially higher than the stem loads required for valve operation, as a result of the bounding nature of the friction coefficients in the method

  1. Diseases of the Tricuspid Valve

    Science.gov (United States)

    ... Myocarditis Obstructive Sleep Apnea Pericarditis Peripheral Vascular Disease Rheumatic Fever Sick Sinus Syndrome Silent Ischemia Stroke Sudden Cardiac Arrest Valve Disease Vulnerable Plaque Diseases of the Tricuspid Valve | Share Diseases of the heart valves are grouped according to which valve or ...

  2. Transcatheter CoreValve valve-in-valve implantation in a stentless porcine aortic valve for severe aortic regurgitation

    OpenAIRE

    Yong, Celina M; Buchbinder, Maurice; Giacomini, John C

    2014-01-01

    Key Clinical Message We describe the first valve-in-valve Corevalve transcatheter aortic valve replacement in the St. Jude Toronto stentless porcine aortic valve in the United States, which enabled this 59-year-old patient with a history of bacterial endocarditis and aortic regurgitation to avoid heart transplant with complete resolution of his severe left ventricular dysfunction.

  3. Changes in peripapillary retinal nerve fiber layer thickness in chronic glaucoma and non-glaucoma patients after phacoemulsification cataract surgery

    Directory of Open Access Journals (Sweden)

    Olivia P. Perdana

    2015-12-01

    Full Text Available Background: Phacoemulsification is a common cataract operation nowadays. During phacoemulsification, variation in intraocular pressure (IOP may occur, which might change the retinal nerve fiber layer (RNFL thickness. This study was aimed to evaluate the change in peripapillary RNFL thickness and mean deviation (MD of visual field after phacoemulsification in chronic primary glaucoma and non-glaucoma patients. Methods: Cohort prospective study was done on 26 patients (13 chronic glaucoma eyes and 13 non-glaucoma eyes who underwent phacoemulsification. The changes in peripapillary RNFL thickness and MD of visual field were measured as the primary outcome. Comparison between pre- and post-surgery was analyzed with paired t-test, while unpaired t-test was used for comparison between groups.Results: There were no significant changes in RNFL thickness on both groups. Average RNFL thickness in glaucoma group before and after phacoemulsification were 94.9±20.0 μm and 99.1±21.3 μm, respectively (p>0.05. Average RNFL thickness in non-glaucoma group were 100.2±11.1 μm and 101.7±6.8 μm, respectively (p>0.05. Glaucoma patients yielded decreasing mean deviation (MD of visual field, but it was not statistically significant (p=0.071. In contrast, the MD of visual field after surgery was significantly increased in non-glaucoma group (p=0.005.Conclusion: Phacoemulsification tended to increase peripapillary RNFL thickness in glaucoma or non-glaucoma patients. The visual field tended to decrease in glaucoma patients, but was significantly increased in non-glaucoma patients.

  4. GIANT PROSTHETIC VALVE THROMBUS

    Directory of Open Access Journals (Sweden)

    Prashanth Kumar

    2015-04-01

    Full Text Available Mechanical prosthetic valves are predisposed to bleeding, thrombosis & thromboembolic complications. Overall incidence of thromboembolic complications is 1% per year who are on oral anticoagulants, whereas bleeding complications incidence is 0.5% to 6.6% per year. 1, 2 Minimization of Scylla of thromboembolic & Charybdis of bleeding complication needs a balancing act of optimal antithrombotic therapy. We are reporting a case of middle aged male patient with prosthetic mitral valve presenting in heart failure. Patient had discontinued anticoagulants, as he had subdural hematoma in the past. He presented to our institute with a giant prosthetic valve thrombus.

  5. [Communication towards "lay people" and glaucoma].

    Science.gov (United States)

    Renard, J-P

    2009-03-01

    Glaucoma is particularly frequent and increase with age. Its silent evolution and worsening lead to a delayed diagnosis, until non reversible visual field impairment occurs. Early diagnosis and management, would permit to prevent glaucoma progression and, likely, to reduce the high direct cost of the disease and to preserve patient's quality of life. Furthermore, society changes as well as the weight given to patients' associations, result in an increasing demand for information on the disease, its treatment and on therapeutic education. Physician's specialized scientific Association should play a crucial role in communication towards patients and general population, as already implemented, through several actions since 2004, by the French scientific Societies: Comité de Lutte contre le Glaucome (CLG) and Société Française d'Ophtalmologie (SFO). PMID:19515333

  6. Evidence-based Management of Glaucoma

    Institute of Scientific and Technical Information of China (English)

    Yangfan Yang; Minbin Yu

    2005-01-01

    Purpose: The evidence-based medicine (EBM) is a new medical mode that is completely different from traditional experience-based medicine. The core of EBM is that decision-making during clinical practices must be based on objective research results.With the rapid development of modern ophthalmology, some former viewpoints according to experience-based medicine face challenges. Evidence-based ophthalmology (EBO) is imperative under the situation. Glaucoma, as a disease resulting in blindness, which can not be cured by operation, is thought more and more of by medical management officials and doctors. One challenge for ophthalmologists entering the 21st century will be to make clinical decisions based on valid information or evidence rather than intuition, hearsay, or peer practice. How can we do? Here reviews the application of EBM in medical management of glaucoma since EBM' s naissance and give a reference.

  7. Cellular proliferation after experimental glaucoma filtration surgery

    International Nuclear Information System (INIS)

    We used light microscopic autoradiography to determine the time course of cellular incorporation of tritiated thymidine (a correlate of cell division) following glaucoma filtration surgery in seven eyes of four cynomolgus monkeys with experimental glaucoma. Incorporation of tritiated thymidine was detected as early as 24 hours postoperatively. Peak incorporation occurred five days postoperatively and had returned to baseline levels by day 11. Cells incorporating tritiated thymidine included keratocytes, episcleral cells, corneal and capillary endothelial cells, and conjunctival and corneal epithelial cells. Transmission electron microscopy was correlated with the autoradiographic results to demonstrate that fibroblasts were dividing on the corneoscleral margin. These findings have potential clinical implications for the use of antiproliferative agents after filtration surgery

  8. Glaucoma detection with damato multifixation campimetry online.

    Science.gov (United States)

    Olsen, A S; Alberti, M; Serup, L; la Cour, M; Damato, B; Kolko, M

    2016-05-01

    PurposeTo evaluate Damato Multifixation Campimetry Online (DMCO), a free-of-charge internet-based visual field test. DMCO exists in three versions: DMCO BASIC, DMCO STANDARD, and DMCO ADVANCED. The main focus was (i) to investigate the sensitivity and the specificity of the existing DMCO versions in the detection of glaucomatous visual field loss and (ii) to define and evaluate algorithms for the interpretation of DMCO results.MethodsThe study design was an evaluation of a diagnostic test and included 97 individuals performing DMCO and white-on-white perimetry. Interpretation algorithms were devised to define abnormality, and these were evaluated using the Glaucoma Staging System as gold standard. Receiver operating characteristic (ROC) curves and area under the ROC (AUC) were calculated.ResultsAUCs from 15 algorithms ranged from 0.79 to 0.90. The most promising algorithm combined results from two successive DMCO STANDARD tests. The sensitivity was highly dependent on the severity of glaucoma. Hence, for eyes with mild, moderate, advanced, and severe glaucoma, the DMCO test demonstrated a sensitivity of 11.8, 71.4, 100, and 100%, respectively. The specificity was as high as 98.1%. Median duration per eye to complete the DMCO STANDARD test was 86 s for the control group and 125 s in participants with glaucoma.ConclusionsDMCO shows promise as a free-of-charge online tool to identify glaucomatous visual field defects in a preselected population. Ongoing studies are evaluating the use of DMCO in a nonselected population. PMID:26987590

  9. Valve monitoring ITI-MOVATS

    International Nuclear Information System (INIS)

    ITI-MOVATS provides a wide range of test devices to monitor the performance of valves: motor operated gate or globe valve, butterfly valve, air operated valve, and check valve. The ITI-MOVATS testing equipment is used in the following three areas: actuator setup/baseline testing, periodic/post-maintenance testing, and differential pressure testing. The parameters typically measured with the MOVATS diagnostic system as well as the devices used to measure them are described. (Z.S.)

  10. Cluster headache or narrow angle glaucoma?

    Directory of Open Access Journals (Sweden)

    Prasad Palimar

    1991-01-01

    Full Text Available A 47 year old man with episodes of attacks of pain, redness and mild blurring of vision was investigated for narrow angle glaucoma in view of shallow anterior chambers and a cupped optic disc. The history was reviewed following a spontaneous attack in hospital, which had features other than acute glaucoma. A diagnosis of cluster headache was made on the basis of tests. Cluster headache has been defined as unilateral intense pain, involving the eye and head on one side, usually associated with flushing, nasal congestion and lacrimation; the attacks recurring one or more times daily and lasting 20 - 120 minutes. Such attacks commonly continue for weeks or months and are separated by an asymptomatic period of months to years. This episodic nature, together with unilaterality and tendency to occur at night, closely mimics narrow angle glaucoma. Further, if patients have shallow anterior chambers and disc cupping, the differentiation becomes more difficult yet critical. Resource to provocative tests is often the only answer as the following case report demonstrates.

  11. Dry product valve

    International Nuclear Information System (INIS)

    This invention provides a system for delivering particulate radioactive or other toxic wastes to a container in which they can be solidified. The system includes a set of valves that prevent the escape of dusty materials to the atmosphere

  12. Mitral valve regurgitation

    Science.gov (United States)

    ... MVP) Rare conditions, such as untreated syphilis or Marfan syndrome Rheumatic heart disease. This is a complication ... the arteries Heart failure - overview High blood pressure Marfan syndrome Mitral valve prolapse Pulmonary embolus Stroke Update ...

  13. Mitral valve regurgitation

    Science.gov (United States)

    ... valve prolapse (MVP) Rare conditions, such as untreated syphilis or Marfan syndrome Rheumatic heart disease. This is ... P, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine . 9th ed. Philadelphia, PA: Elsevier Saunders; 2011: ...

  14. When a Mechanical Valve Goes Freestyle: A Patient Tailored Valve-In-Valve Implantation.

    Science.gov (United States)

    François, J; Cathenis, K; Hamerlijnck, R

    2015-01-01

    In case of a redo operation after a full root replacement there are two possible options: replacing the entire root or performing a more conservative valve-in-valve implantation. Regarding the relatively high morbidity and mortality of a redo root replacement, the valve-in-valve implantation is the preferred choice if technically feasible. We present the case of a valve-in-valve implantation with a St. Jude mechanical valve in a Medtronic bioprosthesis in a 57-year old man. Follow-up echocardiography after 1 month showed a mean gradient of 17 mmHg and no paravalvular leakage. The combination of a St. Jude bileaflet mechanical valve implanted in a Freestyle root prosthesis has not been described. This case shows that patient tailored treatment with a St. Jude bileaflet mechanical valve in a Freestyle aortic root valve can be safely performed and might be the preferred choice for younger patients, if technically feasible. PMID:26560005

  15. Hidden $U(1)_Y$ Ward-Takahashi identities, absence of Brout-Englert-Higgs fine-tuning, decoupling of certain heavy particles, due to spontaneous symmetry breaking II: The Abelian Higgs model (AHM), extended-AHM, derivations and examples

    CERN Document Server

    Lynn, Bryan W

    2015-01-01

    This work is dedicated to the memory of R. Stora. The spontaneously broken (SSB) $U(1)_Y$ Abelian Higgs model (AHM) (the gauge theory of a scalar $\\phi \\propto (H+i\\pi)= {\\tilde H}e^{i{\\tilde \\pi}/}$ and a transverse vector A) has a massless pseudo-scalar $\\pi$ in Lorenz gauge. Physical states have a conserved global current and Goldstone theorem (GT). $\\tilde \\pi$ becomes a Nambu-Goldstone boson (NGB). Slavnov-Taylor identities keep on-shell T-matrix elements of physical states independent of anomaly-free gauge, and global, transformations, yielding towers of $\\phi$-sector Ward-Takahashi Identities (WTI), and constraining external $\\phi$ dynamics. Ultraviolet quadratic divergences (UVQD) contribute only to $m_\\pi^2$, forced by the GT to 0, so all UVQD vanish. Weak-scale renormalized gauge-independent Higgs pole-mass and VEV are therefore not fine-tuned. The NGB is "eaten" and decouples, hiding the $U(1)_Y$ WTI from observable particle physics. Our regularization-scheme-independent results are unchanged by th...

  16. Aortic valve replacement

    DEFF Research Database (Denmark)

    Kapetanakis, Emmanouil I; Athanasiou, Thanos; Mestres, Carlos A;

    2008-01-01

    BACKGROUND AND AIMS OF THE STUDY: Prompted by anecdotal evidence and observations by surgeons, an investigation was undertaken into the potential differences in implanted aortic valve prosthesis sizes, during aortic valve replacement (AVR) procedures, between northern and southern European countr...... southern European countries. Imbalances in the prevalence of rheumatic heart disease, health resource availability and variations in surgical practice throughout Europe might be possible etiological causes....

  17. Keeping valves in check

    International Nuclear Information System (INIS)

    Check valves are located in almost all safety and non-safety related fluid systems in a nuclear power plant. Malfunction or failure of these valves during plant operations, or in some cases under cold shutdown conditions, can seriously affect plant safety and result in costly, time-consuming maintenance. A major cause of check valve failure in the past has been excessive wear of internal components due to high disc flutter. Valve operation under conditions that cause the valve disc and hinge arm to oscillate or flutter can lead to degradations which, if undetected and not corrected, may result in malfunction or failure. Checkmate II, a portable, non-intrusive diagnostic system, has been developed to test various types of check valves using patented ultrasonic testing technology. The system comprises a computer, ultrasonic oscilloscope, transducers, and supporting hardware, and can identify many different phenomena, including: disc position and disc flutter; backstop and seat tapping; relative motion between hinge arm and disc; hinge pin wear and uneven hinge pin wear; disc stud wear and loosened stud nuts; combined stud and hinge pin wear, stuck and missing discs; broken springs. (author)

  18. Retrobulbar diameter of optic nerve in glaucoma

    Directory of Open Access Journals (Sweden)

    Stefanović Ivan

    2009-01-01

    Full Text Available Introduction. The ultrasound diagnostics of the optic nerve includes the analysis of the optic nerve disc (PNO and measuring of its retrobulbar diameter. With B-scan, by Schraeder's method, it is possible to measure very precisely the optic nerve, the pial diameter, the normal values for the pial diameter being 2.8-4.1 mm. In glaucoma, the disease that is most frequently associated with higher intraocular pressure, there comes the destruction of nerve fibres, which can be visualized as the excavation of the optic nerve disc. Objective. In this paper, we were interested in finding whether in glaucoma, and in what phase of the disease, the optic nerve starts growing thinner. Aware of many forms of this very complex disease, we were interested in knowing if the visualization of excavation on the optic nerve disc is related to diminishing of the pial diameter of the retrobulbar nerve part. Methods. There were treated the patients who had already had the diagnosis of glaucoma and the visualized excavation of the optic disc of various dimensions. Echographically, there was measured the thickness of the retrobulbar part of the optic nerve and the finding compared in relation to the excavation of the optic disc. Results. In all eyes with glaucoma, a normal size of the retrobulbar part of the optic nerve was measured, ranging from 3.01 to 3.91 mm with the median of 3.36 mm. Also, by testing the correlation between the thickness of the optic nerve and the excavation of the PNO, by Pearson test, we found that there was no correlation between these two parameters (r=0.109; p>0.05. Conclusion. In the patients with glaucoma, the retrobulbar part of the optic nerve is not thinner (it has normal values, even not in the cases with a totally excavated optic disc. There is no connection between the size of the PNO excavation and the thickness of the retrobulbar part of the optic nerve.

  19. Book review: The superlative city: Dubai and the urban condition in the early twenty-first century edited by Ahmed Kanna

    OpenAIRE

    Housby, Elaine

    2014-01-01

    "The Superlative City: Dubai and the Urban Condition in the Early Twenty-First Century." Ahmed Kanna. Harvard University Press. August 2013. --- In the last few years, the Persian Gulf city of Dubai has exploded from the Arabian sands onto the world stage. Oil wealth, land rent, and so-called informal economic practices have blanketed the urbanscape with enormous enclaved developments attracting a global elite, while the economy runs on a huge army of migrant workers from the labour-exporting...

  20. The impact of available anti-glaucoma therapy on the volume and age profile of patients undergoing glaucoma filtration surgery.

    LENUS (Irish Health Repository)

    Keane, P A

    2012-02-01

    PURPOSE: To investigate whether new classes of glaucoma medication have influenced glaucoma filtration surgery over a 20-year period in the southeast region of Ireland. METHODS: All patients undergoing glaucoma filtration surgery between January 1986 and December 2005 in Waterford Regional Hospital were identified. The following data were recorded for each patient: age; sex; and type of filtration procedure. RESULTS: Over the 20-year study period two consultant ophthalmic surgeons performed a total of 760 glaucoma filtration procedures on patients aged over 20 years. The annual average number of glaucoma surgeries declined steadily, defined by availability of different topical anti-glaucoma medications, from an average of 23.75 surgeries per surgeon per year in the subperiod 1986-1995, to 21 in 1996, 20 in 1997, and 12.69 surgeries per surgeon per year in 1998-2005, these differences being statistically significant (general linear model, P<0.001). The age profile of patients did not change significantly over the course of the study period. CONCLUSIONS: The volume of patients requiring glaucoma filtration surgery under the care of two consultant ophthalmic surgeons decreased over the 20-year study period, an era in which three classes of anti-glaucoma medications were made available. However, an increase in the age profile of patients undergoing glaucoma filtration surgery during the same period was not observed. Further study is required to resolve whether introduction of the new topical anti-glaucoma medications has led to a real reduction in the demand for glaucoma filtration surgery, or has just led to the deferral of such a demand.

  1. Traumatic glaucoma with features of unilateral pigment dispersion.

    Science.gov (United States)

    Bowler, Gordon; Ellul, Antony; Gouws, Pieter

    2014-01-01

    We report a patient with traumatic glaucoma with features of unilateral pigment dispersion. This rare form of secondary glaucoma has only been reported twice previously, with both patients demonstrating angle recession, indicating associated damage to the trabecular meshwork. To our knowledge, this is the first such case reported in which angle recession was absent. PMID:25097455

  2. Role of mitochondria in the pathogenesis and treatment of glaucoma

    Institute of Scientific and Technical Information of China (English)

    YANG Xue-jiao; GE Jian; ZHUO Ye-hong

    2013-01-01

    Objective To gain insight into the potential mechanism of mitochondria dysfunction in pathogenesis,progression and therapeutic management of glaucoma.Data sources The data used in this review were mainly published in English from 2000 to present obtained from PubMed.The search terms were "mitochondria","glaucoma" and 'trabecular meshwork" or "retinal ganglion cells".Study selection Articles studying the mitochondria-related pathologic mechanism and treatment of glaucoma were selected and reviewed.Results Mitochondrial dysfunction or injury was demonstrated in different eye tissue of glaucoma.A variety of potential injuries (light,toxic materials,oxidative injury,mechanical stress,aging,etc.) and the inherent DNA defects are deemed to cause mitochondrial structural and functional destruction in trabecular meshwork cells,retinal ganglion cells,etc.of glaucoma.In addition,various new experimental and therapeutic interventions were used to preserve mitochondrial function,which may be useful for protecting against optic nerve degeneration or reducing the death of retinal ganglion cells in glaucoma.Conclusions Mitochondria play an important role in the pathogenesis of glaucoma,various strategies targeting mitochondrial protection might provide a promising way to delay the onset of glaucoma or protect RGCs against glaucomatous damage.

  3. Optic disc parameters in manifest and suspected glaucoma

    Directory of Open Access Journals (Sweden)

    Lene Martin

    2011-06-01

    Full Text Available Structure and function measurements are important in glaucoma management. Digital fundus photography has become a standard procedure and the Heidelberg Retina Tomograph (HRT, commonly used by glaucoma specialists, provides a glaucoma probability score (GPS. The visual field index (VFI is a novel statistic, aiming to facilitate follow-up of glaucoma patients. The aim of this study was to compare the results from the digital analysis of fundus photographs with HRT measurements including GPS and VFI in patients with ocular hypertension, suspect glaucoma or glaucoma, and if possible define an optic disc index, useful in glaucoma diagnosis. Fifty-eight consecutive patients from a glaucoma service were included. Optic disc parameters (disc and cup areas were measured on digital fundus photographs, using a semi-automatic method, and compared with the GPS from the HRT and the VFI from standard automated perimetry. A significant relationship was observed between the GPS group classification (normal, borderline, or abnormal and VFI classification (normal or abnormal, both when the GPS borderline group was regarded as normal (P = 0.0038 Fisher test and as abnormal (P=0.0179, kappa = 0.33. No significant relationship was observed between VFI and optic disc parameters. The threedimensional information in the GPS appears to be more related to visual function, as measured by VFI, than the planimetric measures of the optic disc.

  4. Primary congenital glaucoma associated with Patau syndrome with long survival.

    Science.gov (United States)

    Jaru-Ampornpan, Pimkwan; Kuchtey, John; Dev, V G; Kuchtey, Rachel

    2010-01-01

    Ocular abnormalities are common in Patau syndrome (trisomy 13), but only a few cases with congenital glaucoma have been reported, some of which were associated with other ocular defects. This report describes a case of primary congenital glaucoma in an 11-year-old patient with full trisomy 13. PMID:21080618

  5. Prevalence and determinants of glaucoma : an epidemiologic approach (The Rotterdam Study)

    NARCIS (Netherlands)

    I. Dielemans (Ida)

    1995-01-01

    textabstractGlaucoma is an eye disease characterized by damage to the optic nerve head and related visual field defects, often accompanied by elevated intraocular pressure. Glaucoma is an important cause of blindness, particularly in the elderly. One may divide glaucoma in primary glaucoma without k

  6. Association of ABO blood groups with glaucoma in the Pakistani population.

    NARCIS (Netherlands)

    Khan, M.I.; Micheal, S.; Akhtar, F.; Naveed, A.; Ahmed, A.; Qamar, R.

    2009-01-01

    OBJECTIVE: To study the association of blood groups with different types of glaucoma including primary open-angle glaucoma (POAG), primary closed-angle glaucoma (PCAG), and pseudoexfoliative glaucoma (PEXG) in the Pakistani population. STUDY DESIGN: The present study was a prospective case control s

  7. [The retinal nerve fiber layer in normal and glaucoma eyes].

    Science.gov (United States)

    Jonas, J B; Schiro, D; Naumann, G O

    1993-12-01

    Glaucoma leads to changes of the retinal nerve fiber layer (RNFL). This study was performed to evaluate glaucomatous alterations of the RNFL and to correlate them with other parameters of glaucomatous optic nerve damage. The study included red-free wide-angle fundus photographs of the RNFL of 453 normal eyes and 609 eyes with glaucoma. We evaluated the visibility of the RNFL in different fundus regions and the occurrence of localized RNFL defects. In the glaucoma eyes, including those with "early" glaucomatous optic nerve damage, the visibility of RNFL was significantly lower than in the normal eyes. The degree of RNFL visibility correlated with other morphological and perimetric parameters. Localized RNFL defects were detected in 20% of the glaucoma eyes. Their frequency increased significantly (P diffuse RNFL loss, the varying frequency of localized RNFL defects in different types of glaucoma and the association between localized RNFL defects and optic disk hemorrhages are diagnostically and pathogenetically important. PMID:8124022

  8. 影响AHM与DINA诊断准确率的因素研究%The Research on Factors Influencing Diagnostic Accuracy in AHM and DINA

    Institute of Scientific and Technical Information of China (English)

    颜远海; 丁树良; 汪文义

    2011-01-01

    Cognitive diagnostic theory is the product of combination cognitive psychology with modern psychological and educational measurement and it is a core of the new theoretical generation. Various factors, such as attribute hierarchy, test blueprint and test length, and the quality of the items, I.e., the quantity of the slip attached to . An item will affect the accuracy of diagnosis to some extent. Based on two diagnosis models AHM and DINA, affecting degree of different factors to accuracy index of classification is investigated in the paper. The results show different factors have varying degree of influence on the accuracy of diagnosis. Test-length is not the longer the better when attribute structure is linear. Different test blueprint has varying degree of influence on the diagnostic accuracy. A cognitive test that contains reachability matrix has a higher classification accuracy rate than that of not contained. The higher the slip, the lower the pattern and the marginal classification accuracy rate are. The more compact the attribute hierarchy, the higher classification accuracy rate. AHM is more sensitive to attribute construction, while DINA is not. Generally speaking, the accuracy of classification of DINA is higher than AHM, but sometimes DINA model may provide some unreasonable estimate of knowledge states. This finding does not coincide with DeCarlo's conclusion.%对属性层级模型(AHM)和确定性输入、噪声“与”门模型(DINA)2个认知诊断模型,讨论不同因素对判准率的影响.实验表明,含有可达阵的测验比不含可达阵的测验判准率高.对于线型结构测验长度达到一定值以后,增加测验长度对诊断准确率的改进不大.虽然总体而言,DINA分类准确性要优于AHM,属性结构紧密度越大,判准率越高;但是AHM估计结果符合属性层级结构,而DINA估计结果却可能违背属性层级关系,这和2011年De Carlo的发现不相同.

  9. Higher serum lipids and oxidative stress in patients with normal tension glaucoma, but not pseudoexfoliative glaucoma

    Science.gov (United States)

    Yilmaz, Necat; Coban, Deniz Turgut; Bayindir, Asli; Erol, Muhammet Kazim; Ellidag, Hamit Yasar; Giray, Ozlem; Sayrac, Suha; Tekeli, Seckin Ozgur; Eren, Esin

    2016-01-01

    This study entailed a cross-examination of oxidant/antioxidant balance, high-density lipoprotein (HDL)-linked paraoxonase 1 (PON1) phenotypes, and levels of serum routine lipids among patients with normal tension glaucoma (NTG) or pseudoexfoliative glaucoma (PEXG) compared with healthy control groups. We aimed to investigate the links between oxidative stress (OS), HDL-related antioxidant enzyme activities and dyslipidemia in distinct subtypes of glaucoma. The study included 32 patients with NTG, 31 patients with PEXG, and 40 control subjects. Levels of PON1 and arylesterase enzymatic activity, total oxidant status (TOS), and total antioxidant status were measured by spectrophotometry and OS indexes (OSI) were calculated. The phenotype distribution of PON1 was determined using the dual substrate method. Blood serum levels of HDL, low-density lipoprotein, total cholesterol (TC), and triglyceride (TG) were measured. The TOS and OSI values in the NTG group were significantly higher compared with the other groups (both p < 0.01). The phenotype distribution found in the glaucoma and control groups were NTG: QQ, 59.4%; QR, 37.5%; RR, 3.1%; PEXG: QQ, 45.1%; QR, 48.4%; RR, 6.5%; and in the control group: QQ, 42.5%; QR, 50.0%; RR, 7.5%. Serum TC levels were significantly higher than the control in both NTG and PEXG groups, whereas TG was significantly higher in NTG only (p < 0.01 and p < 0.02, respectively). Hyperlipidemia, OS and variations in phenotype distribution of PON1 may play a role in the pathogenesis of different types of glaucoma. PMID:26773174

  10. [Mineralization of heart valves].

    Science.gov (United States)

    Pawlikowski, M; Pfitzner, R

    1992-01-01

    Mineralization (calcification) of heart valves (mitral, aortic and aortic bioprosthesis) have been analyzed using; histology, x-ray diffraction, infrared spectroscopy, scanning microscopy, atomic absorption and electron microprobe. Obtained results showed the presence of two type of mineralization. First type is represented by grains composed of hydroxyapatite containing admixture of carbonates. This mineralization is seen macroscopically. Second type of mineralization is possible to determine only using chemical methods. It is represented by biological structures containing amount of Ca, P and other elements higher then normal heart valves. This second type of the mineralization conducts to the changes of physical features of the tissue. Both types of calcification develops because of the defects of atomic structure of biological components of heart valves (mainly collagen). These defects show the presence of free atomic bindings i.e. electric potential. Because of this, they are able to react with surrounding free joints, starting calcification. Defects of biological structures of heart valves are the results of infections, mechanical destruction of the valves etc. Calcification may be stopped on different stages of its development: or as secret calcification or may pass to the stage seen as apatite grains. PMID:1342999

  11. Check valves aging assessment

    International Nuclear Information System (INIS)

    In support of the NRC Nuclear Plant Aging Research (NPAR) program, the Oak Ridge National Laboratory (ORNL) has carried out an assessment of several check value diagnostic monitoring methods, in particular, those based on measurements of acoustic emission, ultrasonics, and magnetic flux. The evaluations have focussed on the capabilities of each method to provide information useful in determining check valve aging and service wear effects, check valve failures, and undesirable operating modes. This paper describes the benefits and limitations associated with each method and includes recent laboratory and field test data, including data obtained from the vendors who recently participated in a comprehensive series of tests directed by a nuclear industry users group. In addition, as part of the ORNL Advanced Diagnostic Engineering Research and Development Center (ADEC), two novel nonintrusive monitoring methods were developed that provide several unique capabilities. These methods, based on external ac- an dc-magnetic monitoring are also described. None of the examined methods could, by themselves, monitor both the instantaneous position and motion of check valve internals and valve leakage; however, the combination of acoustic emission monitoring with one of the other methods provides the means to determine vital check valve operational information

  12. Emission-free valve

    Energy Technology Data Exchange (ETDEWEB)

    Koppe, W.; Prummer, R.

    1980-07-01

    a description is given of an emission-free valve, particularly a magnetically operated valve, for use in controlling the flow of fluids, especially poisonous, radioactive, aggressive and otherwise dangerous gases and fluids, comprising a housing including a housing member which has substantially spherical configuration and an internal surface surrounding a compartment for the respective fluid, said housing further including an annular valve seat member; a valve member movably mounted in said compartment and cooperating with said valve seat member to control the flow of the fluid through said compartment; and a plating layer of a corrosion-resistant material covering said internal surface of said housing member and also having a substantially spherical configuration corresponding to that of said housing member, said housing member and said plating layer obtaining their respective configurations during an explosion which not only simultaneously deforms initially cylindrical tubular and coaxially arranged housing member and plating layer preforms, but also welds said plating layer preform to said housing member preform so that said platinglayer is explosion-welded to said housing member.

  13. Glaucoma and Diabetic Retinopathy in patients with diabetes mellitus type 2. Review.

    OpenAIRE

    Vorobyeva, I. V.; E. V. Shherbakova

    2014-01-01

    Glaucoma and diabetic retinopathy (DR) are the most frequent reasons of visual loss and disability. Combination of glaucoma and DR causes worse prognosis. Similarity of pathogenetic mechanisms of DR and glaucoma allows consideration of more frequent development of primary open-angle glaucoma among patients suffering diabetes mellitus. To reveal these diseases at the earliest stages is one of the most difficult ophthalmological problems. The contemporary methods of DR and glaucoma diagnostics ...

  14. Research on Valve Body Design of Large Bore Sodium Valve

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Large bore sodium valve is one kind of key equipments of China Demonstration Fast Reactor (CDFR). It is installed in the pipeline before and behind SG units as a locking mechanism. Valve body which is used to bear pressure is the core of sodium valve design.

  15. Huge tricuspid valve abscess.

    Science.gov (United States)

    Manzano Nieto, Carmen M; Vilacosta, Isidre; Corros, Cecilia; Almería, Carlos; Rodríguez, Enrique

    2009-03-01

    A 60-year-old woman with colorectal adenocarcinoma underwent surgical mass resection in 2003; hepatic segmentectomy due to hepatic metastasis was performed in 2005. A port-a-cath for the administration of chemotherapy was cannulated. In April 2007, the patient developed fever and shivering, and the catheter was removed. Catheter and blood cultures were positive for methicillin-sensitive Staphylococcus aureus. TEE showed a very mobile mass (3 x 2 cm) at the junction of the posterior and anterior leaflets of the tricuspid valve. The mass had large echolucent areas inside, exhibiting an appearance like a 'ball of wool' (Panel B). Cardiac MRI confirmed the presence of a mass attached to the tricuspid valve, as shown in the delayed enhancement sequence. At surgery, a ruptured tendinous cord as well as a large abscess within the septal leaflet of the tricuspid valve was found. PMID:19196752

  16. Josephson magnetic rotary valve

    International Nuclear Information System (INIS)

    We propose a control element for a Josephson spin valve. It is a complex Josephson device containing ferromagnetic (F) layer in the weak-link area consisting of two regions, representing 0 and π Josephson junctions, respectively. The valve's state is defined by mutual orientations of the F-layer magnetization vector and boundary line between 0 and π sections of the device. We consider possible implementation of the control element by introduction of a thin normal metal layer in a part of the device area. By means of theoretical simulations, we study properties of the valve's structure as well as its operation, revealing such advantages as simplicity of control, high characteristic frequency, and good legibility of the basic states

  17. Minimally Invasive Aortic Valve Replacement

    Medline Plus

    Full Text Available ... a significant number of mitral valve repairs utilizing robotic techniques as well, which is really outside the ... no significant bleeding. Terry asks if you do robotic valve replacement surgeries. I do not. It's a ...

  18. Minimally Invasive Aortic Valve Replacement

    Medline Plus

    Full Text Available ... which is made out of pyrolitic carbon, basically metal and plastic. Again, blood flows through this valve. ... has a prosthetic valve should let all their treating physicians, dentists, et cetera, know that so that ...

  19. What Is Heart Valve Disease?

    Science.gov (United States)

    ... heart work harder and affect its ability to pump blood. Overview How the Heart Valves Work At the ... into the atria. As the ventricles contract, they pump blood through the pulmonary and aortic valves. The pulmonary ...

  20. Minimally Invasive Aortic Valve Replacement

    Medline Plus

    Full Text Available ... several valve companies in this country and in Europe that have designed catheter-based valves that are ... country in the form of trials and in Europe, actually in more liberal form, for more general ...

  1. Minimally Invasive Aortic Valve Replacement

    Medline Plus

    Full Text Available ... and bovine for cows. Essentially, the tissue from these is harvested from those animals and sewn into ... surface as blood exits through the valve. And these valves are an excellent option. They have great ...

  2. Inexpensive Pressure-Relief Valve

    Science.gov (United States)

    Theordore, E. A.

    1985-01-01

    Simple device vents excess low-pressure gas. Inexpensive pressure relief valve built from polyvinylchloride pipe. Valve suitable for low pressure-- 25 to 50 cm of mercury-- and flow rates up to 14 m3/min.

  3. Transcatheter Aortic Heart Valve Thrombosis

    DEFF Research Database (Denmark)

    Hansson, Nicolaj C; Grove, Erik L; Andersen, Henning R;

    2016-01-01

    BACKGROUND: There is increasing focus on transcatheter heart valve (THV) thrombosis. However, there are limited data on incidence, clinical implications and predisposing factors of THV thrombosis following transcatheter aortic valve replacement (TAVR). OBJECTIVES: We assessed the incidence...

  4. Minimally Invasive Aortic Valve Replacement

    Medline Plus

    Full Text Available ... of that slide, that demonstrates that patients with New York Heart Association class heart failure 1 and ... right down the aortic valve and that's the new aortic valve that Dr. Streitman's placed. And you ...

  5. Comparative study of Butterfly valves

    International Nuclear Information System (INIS)

    This work tries to justify the hydrodynamic butterfly valves performance, using the EPRI tests, results carried out in laboratory and in situ. This justification will be possible if: - The valves to study are similar - Their performance is calculated using EPRI's methodology Looking for this objective, the elements of the present work are: 1. Brief EPRI butterfly valve description it wild provide the factors which are necessary to define the butterfly valves similarity. 2. EPRI tests description and range of validation against test data definition. 3. Description of the spanish butterfly analyzed valves, and comparison with the EPRI performance results, to prove that this valves are similar to the EPRI test valves. In this way, it will not be necessary to carry out particular dynamic tests on the spanish valves to describe their hydrodynamic performance. (Author)

  6. Minimally Invasive Aortic Valve Replacement

    Medline Plus

    Full Text Available ... a chronic disease process of inflammation and protein deposition that ultimately results in calcification of the valve. ... heart valve which is made out of pyrolitic carbon, basically metal and plastic. Again, blood flows through ...

  7. Minimally Invasive Aortic Valve Replacement

    Medline Plus

    Full Text Available ... really, they are two-fold for us to explain to you that, first, there are more significant ... size valve in as possible, as well as making sure that the valve seats appropriately and that ...

  8. Nuclear reactor steam depressurization valve

    International Nuclear Information System (INIS)

    This patent describes improvement in a nuclear reactor plant, an improved steam depressurization valve positioned intermediate along a steam discharge pipe for controlling the venting of steam pressure from the reactor through the pipe. The improvement comprises: a housing including a domed cover forming a chamber and having a partition plate dividing the chamber into a fluid pressure activation compartment and a steam flow control compartment, the valve housing being provided with an inlet connection and an outlet connection in the steam flow control compartment, and a fluid duct in communication with a source of fluid pressure for operating the valve; a valve set mounted within the fluid flow control compartment comprising a cylindrical section surrounding the inlet connection with one end adjoining the connection and having a radially projecting flange at the other end with a contoured extended valve sealing flange provided with an annular valve sealing member, and a valve cylinder traversing the partition plate and reciprocally movable within an opening in the partition plate with one terminal and extending into the fluid pressure activation compartment and the other terminal end extending into the steam flow control compartment coaxially aligned with the valve seat surrounding the inlet connection, the valve cylinder being surrounded by two bellow fluid seals and provided with guides to inhibit lateral movement, an end of the valve cylinder extending into the fluid flow control compartment having a radially projecting flange substantially conterminous with the valve seat flange and having a contoured surface facing and complimentary to the contoured valve seating surface whereby the two contoured valve surfaces can meet in matching relationship, thus providing a pressure actuated reciprocatable valve member for making closing contact with the valve seat and withdrawing therefrom for opening fluid flow through the valve

  9. St Jude Medical Portico valve.

    Science.gov (United States)

    Manoharan, Ganesh; Spence, Mark S; Rodés-Cabau, Joseph; Webb, John G

    2012-09-01

    Transcatheter aortic valve implantation is increasingly being used to treat high-risk patients with symptomatic aortic valve disease. However, challenges still remain with current devices, both in terms of the procedure and the outcome. The St Jude Medical Portico transcatheter valve system is designed to mitigate some of these difficulties. We describe the device characteristics and how the device may impact on a TAVI procedure. An overview of the clinical experiences with the Portico valve system is also described. PMID:22995122

  10. Building valve amplifiers

    CERN Document Server

    Jones, Morgan

    2013-01-01

    Building Valve Amplifiers is a unique hands-on guide for anyone working with tube audio equipment--as an electronics hobbyist, audiophile or audio engineer. This 2nd Edition builds on the success of the first with technology and technique revisions throughout and, significantly, a major new self-build project, worked through step-by-step, which puts into practice the principles and techniques introduced throughout the book. Particular attention has been paid to answering questions commonly asked by newcomers to the world of the valve, whether audio enthusiasts tackling their first build or

  11. Pressure Relief Valve

    Science.gov (United States)

    1985-01-01

    "Sputtering" is the process of applying film-like metal coatings onto a surface by bombarding the coating material with electrocharged ions. This causes the material to disintegrate and relocate on the substrate an atom layer at a time. The process allows a variety of coating materials to be deposited on various surfaces. Deposition Technology, Inc. (DTI) uses "sputtering" for window films, packaging materials, etc. Valves installed on two vacuum chambers which are part of DTI's system, were developed by Lewis Research Center and detailed in Tech Briefs. The valve protects the environment and frees the operator from monitoring the chamber venting.

  12. Epidemiological characterization of primary open-angle glaucoma

    Directory of Open Access Journals (Sweden)

    Leonor Rosario Díaz Alfonso

    2010-11-01

    Full Text Available Background: The primary open-angle glaucoma is a problem for public health all over the world. It is a silent and slowly progressive disease leading to blindness. In most patients this can be prevented if the risk factors leading to the disease are detected in time. Objective: To describe some epidemiological factors of patients with primary open-angle glaucoma. Methods: Clinical, epidemiological, prospective and longitudinal study in patients with primary open-angle glaucoma who attended the glaucoma consultation of the Provincial General University Hospital "Dr. Gustavo Aldereguía Lima" of Cienfuegos, from January to February 2009. The following variables were analyzed: age, sex, family and personal medical history, toxic habits and time of diagnosis of the disease. Results: There was prevalence of primary open-angle glaucoma (87, 5% mostly in females (53, 6% and patients over 61 years old as well as in white skinned patients (52 and 62% respectively. Hypertension was the leading entity referred to as pathological personal and family antecedent (62 and 42% respectively. Glaucoma and myopia predominated as previous eye history. The most frequent toxic habits were the consumption of more than 2 cups of coffee a day (53% and smoking (32%. The largest amount of patients had more than 5 years evolution of the disease. Conclusions: Primary open-angle glaucoma occurred mainly in female patients and those with a history

  13. Citalopram associated with acute angle-closure glaucoma: case report

    Directory of Open Access Journals (Sweden)

    Hassan Sabit

    2005-10-01

    Full Text Available Abstract Background Acute angle-closure glaucoma is a rare complication in patients receiving anti-depressant treatment. In the following case, we report the development of acute angle closure glaucoma in a patient who overdosed on Citalopram, an antidepressant, and discuss the possible etiological mechanisms for the condition. Case presentation We report a 54 year old, Caucasian lady, with depression and alcohol dependence syndrome, who developed acute angle-closure glaucoma after an overdose of Citalopram, along with alcohol. She was treated with medications and had bilateral Yag laser iridotomies to correct the glaucoma and has made complete recovery. In this case, the underlying cause for glaucoma appears to be related to the ingestion of Citalopram. Conclusion The patho-physiological basis for acute angle closure glaucoma in relation to antidepressant medications remains unclear. The authors suggest Citalopram may have a direct action on the Iris or Ciliary body muscle through serotonergic or anti-cholinergic mechanisms or both. This case highlights the importance of the awareness of the underlying risks, which may predispose an individual to develop acute angle-closure glaucoma, and reminds the clinicians the significance of history taking and examination of the eye before and after starting anti-depressants. This area needs to be further researched.

  14. The Probability of Blindness in Patients Treated for Glaucoma

    Directory of Open Access Journals (Sweden)

    Li-Chun Chang

    2005-07-01

    Full Text Available Background: To investigate the risk factors and probability of blindness in patients treatedfor glaucoma.Methods: The study design was a retrospective, hospital-based, clinical chart, reviewstudy. Medical records were reviewed from patients seen between January2003 and December 2003 at the Kaohsiung Chang Gung Memorial Hospitaleye clinic, who had been diagnosed with glaucoma in 1986 or later and whohad been treated for at least 2 years for glaucoma.Results: A total of 186 charts were reviewed, which included 66 patients who wereblind in at least one eye from glaucoma on presentation. A total of 172patients and 290 eyes were followed-up for a mean duration of 10.6 4.67years. Twenty seven patients and 31 eyes developed blindness from glaucomaduring follow-up. The Kaplan-Meier survival estimate at 16 years was28.6% for glaucoma-related blindness in at least one eye. A worse visualfield on presentation, older age, and poor compliance during therapy weresignificantly associated with the development of blindness. Glaucoma type, agender difference, systemic disease, greater intraocular pressure fluctuationin the last year of therapy and blindness in one eye on presentation did notshow a significant relationship with the rate of development of blindness.Conclusion: Blindness from treated glaucoma is considerable. Our results gave a 28.6%probability of blindness at 16 years in at least one eye. An older age, poorcompliance and a worse visual field on presentation were significant risk factors.

  15. Angioid streaks - a rare cause of neovascular glaucoma. Case report.

    Science.gov (United States)

    Ungureanu, E; Geamanu, A; Careba, I; Grecescu, M; Gradinaru, S

    2014-01-01

    Rationale. Neovascular glaucoma is the type of glaucoma most refractory to treatment. The most frequent causes are those associated with retinal hypoxia, such as proliferative diabetic retinopathy, central retinal vein occlusion, branch retinal vein occlusion, central retinal arterial occlusion, ischemic ocular syndrome etc. Rare causes of neovascular glaucoma are multiple and are due to VEGF synthesis associated with chorioretinal inflammations or degenerations. We present a case with neovascular glaucoma associated with an extremely rare cause, angioid streaks Objective. The objective of our prsentation was to asses efficacy of the 5-FU associated trabeculectomy following bevacizumab intravitreal administration Methods and results. Case report of a 48 years old female patient which presented at the emergency room with painful red left eye. At presentation best corrected left eye visual acuity was 1/10, intraocular pressure was 36 mm Hg. Examination established the diagnosis of Neovascular glaucoma associated with angioid streaks. After intravenous Manitol, oral Acetazolamide and topical treatment with fixed combination timolol-brinzolamide, topical steroid and mydriatic intraocular pressure decreased. Intravitreal bevacizumab injection was performed, followed after 3 weeks by trabeculectomy. Discussion. Angioid streaks are an extremely rare cause of neovascular glaucoma. The treatment is similar to the treatment for other causes of neovascular glaucoma. PMID:27057253

  16. Surgical outcomes of the Ex-PRESS glaucoma filtration device in African American and white glaucoma patients

    Directory of Open Access Journals (Sweden)

    Salim S

    2012-06-01

    Full Text Available Sarwat Salim, Haiming Du, Sumalee Boonyaleephan, Jim WanUniversity of Tennessee Health Science Center, Memphis, TN, USAPurpose: To compare the surgical outcomes of the Ex-PRESS glaucoma filtration device in African American and white glaucoma patients.Design: Retrospective comparative case series.Methods: This was a comparative case series of 36 eyes of 36 African Americans and 43 eyes of 43 whites that underwent placement of the Ex-PRESS glaucoma filtration device under a partial-thickness scleral flap for uncontrolled glaucoma. All eyes received intraoperative mitomycin C. The primary outcome measures were intraocular pressure (IOP, number of postoperative glaucoma medications, and surgical success. Surgical success was defined as IOP between 5 and 18 mm Hg, with or without glaucoma medications, without further glaucoma surgery, or loss of light perception vision. Results: Average follow-up was 31.9 ± 9.8 (range, 14.6–47 months for African Americans and 30.7 ± 8.6 (range, 14.3–47 months for whites. At 33 months, surgical success was 80.0% in the African American group and 83.3% in the white group (P = 1.00. Reasons for surgical failure included increased IOP (3 eyes, 3.8%, persistent hypotony with maculopathy (1 eye, 1.3%, and further surgery (4 eyes, 5.06%. Compared with preoperative values, the mean postoperative IOP and number of glaucoma medications were significantly reduced in both groups, and no statistical difference was observed between the two groups at 33 months. Postoperative complications were similar in the two groups.Conclusions: Similar surgical outcomes were observed in African American and white glaucoma patients after implantation of the Ex-PRESS glaucoma filtration device. This latest modification of glaucoma filtration surgery may be a better surgical option for African Americans given its potential advantages of no tissue removal, predictable outcomes related to consistent lumen size and controlled flow, fewer

  17. Glaucoma in Iran and contributions of studies in Iran to the understanding of the etiology of glaucoma

    Directory of Open Access Journals (Sweden)

    Fatemeh Suri

    2015-01-01

    Full Text Available Epidemiologic and genetic/molecular research on glaucoma in Iran started within the past decade. A population-based study on the epidemiology of glaucoma in Yazd, a city in central Iran, revealed that 4.4% of studied individuals were affected with glaucoma: 1.6% with high tension primary open angle glaucoma (POAG, 1.6% with normal tension POAG, and 0.4% each with primary angle closure glaucoma (PACG and pseudoexfoliation glaucoma (PEXG, and other types of secondary glaucoma. Two notable observations were the relatively high frequency of normal tension glaucoma cases (1.6% and the large fraction of glaucoma affected individuals (nearly 90% who were unaware of their condition. The first and most subsequent genetic studies on glaucoma in Iran were focused on primary congenital glaucoma (PCG showing that cytochrome P450 1B1 (CYP1B1 is the cause of PCG in the majority of Iranian patients, many different CYP1B1 mutations are present among Iranian patients but only four mutations constitute the vast majority, and the origins of most mutations in the Iranians are identical by descent (IBD with the same mutations in other populations. Furthermore, most of the PCG patients are from the northern and northwestern provinces of Iran. A statistically significant male predominance of PCG was observed only among patients without CYP1B1 mutations. Clinical investigations on family members of PCG patients revealed that CYP1B1 mutations exhibit variable expressivity, but almost complete penetrance. A great number of individuals harboring CYP1B1 mutations become affected with juvenile onset POAG. Screening of JOAG patients showed that an approximately equal fraction of the patients harbor CYP1B1 and (myocilin MYOC mutations; MYOC is a well-known adult onset glaucoma causing gene. Presence of CYP1B1 mutations in JOAG patients suggests that in some cases, the two conditions may share a common etiology. Further genetic analysis of Iranian PCG patients led to

  18. Telocytes in human heart valves

    Science.gov (United States)

    Yang, Yang; Sun, Wei; Wu, Sean M; Xiao, Junjie; Kong, Xiangqing

    2014-01-01

    Valve interstitial cells (VICs) are responsible for maintaining the structural integrity and dynamic behaviour of the valve. Telocytes (TCs), a peculiar type of interstitial cells, have been recently identified by Popescu*s group in epicardium, myocardium and endocardium (visit http://www.telocytes.com). The presence of TCs has been identified in atria, ventricles and many other tissues and organ, but not yet in heart valves. We used transmission electron microscopy and immunofluorescence methods (double labelling for CD34 and c-kit, or vimentin, or PDGF Receptor-β) to provide evidence for the existence of TCs in human heart valves, including mitral valve, tricuspid valve and aortic valve. TCs are found in both apex and base of heart valves, with a similar density of 27–28 cells/mm2 in mitral valve, tricuspid valve and aortic valve. Since TCs are known for the participation in regeneration or repair biological processes, it remains to be determined how TCs contributes to the valve attempts to re-establish normal structure and function following injury, especially a complex junction was found between TCs and a putative stem (progenitor) cell. PMID:24674389

  19. Cavitation problems in sodium valves

    International Nuclear Information System (INIS)

    Cavitation poses few problems for sodium valves, in spite of the fact that the loops are not pressurized. This is no doubt due to the low flow velocities in the pipes. For auxiliary loop valves we are attempting to standardize performances with respect to cavitation. For economic reasons cavitation thresholds are approached with large diameter valves. (author)

  20. [Progression of drug delivery system for glaucoma].

    Science.gov (United States)

    Xu, Yan; Lyu, Liu

    2014-12-01

    Reduction of intraocular pressure (IOP) by drugs is a major treatment for glaucoma. Clinically, diverse antiglaucoma drugs take effect to decrease the IOP through different mechanisms.However, due to limitations of traditional form of eye drops, the bioavailability of the drug and the patient compliance is lowered, the clinical efficacy is not good and also some toxic and side-effects come out.Otherwise, traditional medication is not suitable for neuroprotective drugs to work on both retina and optic nerve. Drug delivery system has the potential to improve the bioavailability of the drug, prolong the time of drug action, decrease the dosage and frequency of drugs, reduce the side-effects, and improve the patient compliance and efficacy.It is one of the most important studies in glaucoma medication development because it is valuable for patients' neuroprotection.Nowadays, several novel delivery systems have been designed. This review will focus on the progressions of some of the sustained-release antiglaucoma eye drops, polymeric gels, colloidal systems, membrane-controlled drug delivery system, ocular implants, and transscleral drug delivery systems. PMID:25619186

  1. The Prevalence of Glaucoma in Tehran, Iran

    Directory of Open Access Journals (Sweden)

    Heydar Amini

    2008-11-01

    Full Text Available

    PURPOSE: To determine the prevalence of glaucoma in adults 40 years of age or older in Tehran, Iran. METHODS: This stratified random-sampling cross-sectional population survey was performed on residents of Tehran, the capital of Iran, aged 40 years and older in the year 2001. Refraction, best-corrected visual acuity, slitlamp biomicroscopy, Goldmann applanation tonometry, funduscopy, and gonioscopy were performed in all subjects. Automated perimetry was performed in selected cases. RESULTS: Out of 4418 sampled subjects, 2184 individuals (49.4% participated in the survey. Eventually data from 2160 individuals including 814 (38% male and 1346 (62% female subjects with mean age of 55.1±10.2 (range 40-92 years were analyzed. The overall prevalence of glaucoma was 1.44% (95% confidence interval, 0.94-1.94 including primary open angle glaucoma 0.46%, chronic angle closure glaucoma 0.33%, normal tension glaucoma 0.28%, pseudoexfoliation glaucoma 0.23%, and other types of glaucoma 0.14%. More than 80% of affected subjects were unaware of their condition. CONCLUSION: The prevalence of glaucoma in adults 40 years of age or older in Tehran is 1.44%, which is in the lower range

  2. Active noncontact tonometer for glaucoma detection

    Science.gov (United States)

    Han, Yanmei; Bryanston-Cross, Peter J.; Lee, Wing K. A.; Hero, Mark

    2002-09-01

    Glaucoma is an increasingly common cause of visual impairment, and in some cases causes blindness. The approach to develop a low cost and non-contact tonometer for the detection of glaucoma, to replace the Goldmann tonometer used worldwide, is presented in this paper. The new tonometer exploits the vibration property of the cornea - the resonance frequency of the cornea rises with increasing intra-ocular pressure (IOP). An audio frequency signal is used to vibrate the cornea of the eye, the vibration of the cornea is measured using a fibre optic lever probe, and then the IOP can be calculated from the detected resonance frequency of the cornea. The initial PC-version experiment system of the new tonometer has been demonstrated and preliminary testing has been performed, showing a suitable sensitivity in detecting the resonance frequency against the IOP using both the simulated-eye model and the pig's eye. The initial system has been improved to be suitable for greater than 15mm detecting distance, and the measurement of vibrations of human cornea in-vivo has been carried out. Work is now focusing on increasing the sensitivity of the fibre probe, and reducing the measuring time to less than 1 second.

  3. Comparison of Central Corneal Thickness Measurements by Ultrasonic Pachymetry, Orbscan II, and SP3000P in Eyes with Glaucoma or Glaucoma Suspect

    OpenAIRE

    Mei-Ching Teng; Ing-Chou Lai; Tsung-Ho Ou

    2012-01-01

    Background: Intraocular pressure (IOP) measurements are affected by the central cornea thickness (CCT). The conventional method for CCT measurement is ultrasonic pachymetry. However, noncontact procedures lower the risk of infection and corneal damage. In this study, we compared the CCT measured by Orbscan II, SP3000P, and ultrasonic pachymetry in patients with glaucoma or glaucoma suspect.Methods: The CCT of 208 eyes (46 eyes with glaucoma suspect, 42 with primary angle-closure glaucoma, and...

  4. Single-step primary open-angle glaucoma and complicated cataract surgery using modified technique of stainless steel Glaucoma Filtration Device implantation

    OpenAIRE

    I. L. Bessonov; J. A. Gusev; V. N. Trubilin; S. M. Makkaeva

    2014-01-01

    Purpose: To analyze the efficacy of novel technique of primary open-angle glaucoma (POAG) and complicated cataract surgery that combines phacoemulsification and modified stainless steel Glaucoma Filtration Device implantation.Methods: 34 patients (38 eyes) with POAG and complicated cataract were included in the study. Phacoemulsification with Glaucoma Filtration Device implantation using improved technique (i.e., with additional collagen glaucoma drainage implantation and posterior scleral im...

  5. Laser Applications on Iris for Treatment of Glaucoma

    Directory of Open Access Journals (Sweden)

    Ahmet Özkök

    2013-06-01

    Full Text Available Laser applications on iris for the treatment of glaucoma include laser iridotomy (LI and laser peripheral iridoplasty (LPI. LI is a simple and effective modality for treatment of closed-angle glaucoma with pupillary block. LPI is an easy and effective treatment for closed angle in situations in which LI either cannot be performed or does not repair the appositional angle closure because mechanisms other than pupillary block are present. The aim of this review is to summarize the indications, technique details, and complications of laser applications on iris for the treatment of glaucoma. (Turk J Ophthalmol 2013; 43: 190-4

  6. Aniridia associated with congenital aphakia and secondary glaucoma

    Directory of Open Access Journals (Sweden)

    Moreker Mayur

    2009-01-01

    Full Text Available We report a case of aniridia associated with congenital aphakia and secondary glaucoma. A 35-year-old male presented with aniridia, congenital aphakia and secondary glaucoma in both eyes. After an unsuccessful medical management, he underwent trabeculectomy with mitomycin C and anterior vitrectomy under local anesthesia in his left eye. Postoperatively, at the end of six months, intraocular pressure (IOP in his left eye was controlled without medications. This case highlights the rare association of aniridia with congenital aphakia and secondary glaucoma.

  7. A Congenital Glaucoma Case with Rubinstein-Taybi Syndrome

    Directory of Open Access Journals (Sweden)

    Mümin Hakan Eren

    2011-08-01

    Full Text Available To evaluate systemic/eye manifestations and treatment modalities in a case of Rubinstein-Taybi Syndrome (RTS with bilateral congenital glaucoma and structural eye anomalies. Eight-month-old infant with RTS presented to our clinic with bilateral epiphora and corneal haze in one eye. In ophthalmologic examination, bilateral congenital glaucoma and epiblepharon were found. Medical and surgical treatments of congenital glaucoma were performed. Abnormal eye findings are commonly seen in RTS cases, therefore, ophthalmologic examinations and treatment modalities should be done with caution. (Turk J Ophthalmol 2011; 41: 260-3

  8. Thermostatic Radiator Valve Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Dentz, J.; Ansanelli, E.

    2015-01-01

    A large stock of multifamily buildings in the Northeast and Midwest are heated by steam distribution systems. Losses from these systems are typically high and a significant number of apartments are overheated much of the time. Thermostatically controlled radiator valves (TRVs) are one potential strategy to combat this problem, but have not been widely accepted by the residential retrofit market.

  9. SAFETY SHUTOFF VALVE

    DEFF Research Database (Denmark)

    2009-01-01

    It is disclosed a shut-off valve which acts automatically and has a fully mechanical performance with respect to the loosing of the tower-shape part balance under the effect of the special acceleration Which is arisen from the quakes waves or serious vibrations, while such vibrations are mainly r...

  10. Vent Relief Valve Test

    Science.gov (United States)

    2008-01-01

    Shown is the disassembly, examination, refurbishment and testing of the LH2 ( liquid hydrogen) and LOX (liquid oxygen) vent and relief valves for the S-IVB-211 engine stage in support of the Constellation/Ares project. This image is extracted from high definition video and is the highest resolution available.

  11. Distortion of the CoreValve during transcatheter aortic valve-in-valve implantation due to valve dislocation

    International Nuclear Information System (INIS)

    Nowadays transcatheter aortic valve implantation (TAVI) is an accepted alternative to surgical aortic valve replacement for high-risk patients (pts). Successful TAVI procedures for failed aortic surgical bioprosthesis (TAV-in-SAV) have already been reported. In the presented two cases of TAV-in-SAV implantation a strut distortion of the stent was revealed on angiographic imaging and confirmed on control CT scan. In both procedures, a dislocation of the medtronic core valve (MCV) prosthesis during implantation led to valve retrieval, with a necessity of reloading it in the 18F introducer before subsequent implantation of the same valve in correct position

  12. Liquid metal plasma valve development

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-06-01

    A program for the development of liquid-metal plasma valves (LMPVs) is discussed in detail. The program consisted of two tasks. The first was the development and testing of valves in the laboratory and the fabrication, instrumentation, testing and in-service operation of two valves at the Bonneville Power Adminstration (BPA) facilities of the Pacific Intertie HVDC Power Tansmission System at Celilo, Oregon. The second task was the design, development, fabrication, installation, and operation of a voltage and current monitoring station and the transient event recording system to go with it. Information is present on the design and development of converter valves; LMPV principles; and the testing of prototype valves. (LCL)

  13. Safety and relief valve testing

    International Nuclear Information System (INIS)

    Two major programmes of safety relief valve testing have been established in support of system design and the selection of valves for Sizewell 'B'. The Central Electricity Generating Board has constructed the BRAVO facility to reproduce PWR pressuriser fluid conditions for the full scale testing of pressuriser relief system valves. Current tests on BRAVO, on a full size tandem pair of pressuriser pilot operated safety relief valves, will be followed by the full flow testing of a pressuriser safety valve. Tests at secondary circuit conditions have been carried out at the Siemens Kraftwerk Union Test Facilities, W Germany, where candidate MSSV's have been tested at full scale blowdown conditions. (author)

  14. Distortion of the CoreValve during transcatheter aortic valve-in-valve implantation due to valve dislocation

    Energy Technology Data Exchange (ETDEWEB)

    Souteyrand, Geraud, E-mail: gsouteyrand@chu-clermontferrand.fr [Department of Cardiology, Gabriel Montpied Hospital, CHU Clermont-Ferrand, Clermont-Ferrand (France); ERIM-EA3295, University of Auvergne, Clermont-Ferrand (France); Wilczek, Krzysztof [Department of Cardiology, Medical University of Silesia, Silesian Centre for Herat Diseases, Zabrze (Poland); Innorta, Andrea; Camilleri, Lionel [Department of Cardiology, Gabriel Montpied Hospital, CHU Clermont-Ferrand, Clermont-Ferrand (France); ERIM-EA3295, University of Auvergne, Clermont-Ferrand (France); Chodor, Piotr [Department of Cardiology, Medical University of Silesia, Silesian Centre for Herat Diseases, Zabrze (Poland); Lusson, Jean-René; Motreff, Pascal [Department of Cardiology, Gabriel Montpied Hospital, CHU Clermont-Ferrand, Clermont-Ferrand (France); ERIM-EA3295, University of Auvergne, Clermont-Ferrand (France); Laborde, Jean-Claude [St. George' s Hospital, London (United Kingdom); Chabrot, Pascal; Durel, Nicolas [Department of Cardiology, Gabriel Montpied Hospital, CHU Clermont-Ferrand, Clermont-Ferrand (France); ERIM-EA3295, University of Auvergne, Clermont-Ferrand (France)

    2013-09-15

    Nowadays transcatheter aortic valve implantation (TAVI) is an accepted alternative to surgical aortic valve replacement for high-risk patients (pts). Successful TAVI procedures for failed aortic surgical bioprosthesis (TAV-in-SAV) have already been reported. In the presented two cases of TAV-in-SAV implantation a strut distortion of the stent was revealed on angiographic imaging and confirmed on control CT scan. In both procedures, a dislocation of the medtronic core valve (MCV) prosthesis during implantation led to valve retrieval, with a necessity of reloading it in the 18F introducer before subsequent implantation of the same valve in correct position.

  15. Inter-eye comparison of retinal oximetry and vessel caliber between eyes with asymmetrical glaucoma severity in different glaucoma subtypes

    Science.gov (United States)

    Cheng, Clarissa Shu Ming; Lee, Yi Fang; Ong, Charles; Yap, Zhu Li; Tsai, Andrew; Mohla, Aditi; Nongpiur, Monisha E; Aung, Tin; Perera, Shamira A

    2016-01-01

    Background To compare retinal vessel oxygenation and vessel caliber in primary angle-closure glaucoma (PACG), primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and normal controls, as well as between eyes of asymmetrical glaucoma severity. Methods This was a prospective, cross-sectional study. The 159 subjects (PACG, n=39; POAG, n=41; NTG, n=41; normal controls, n=38) underwent retinal oxygen saturation measurements using the Oxymap T1 Retinal Oximeter, optical coherence tomography, and Humphrey visual field testing. Retinal oxygen saturation and vessel diameter were compared between the glaucoma groups and normal controls, as well as between eyes of asymmetrical glaucoma severity. Kruskal–Wallis test was performed for comparison among different subtypes of glaucoma. Wilcoxon signed-rank test was used to compare the inter-eye differences. Results Compared to normal controls, arteriolar oxygen saturation was increased in PACG eyes (P=0.048) but not in POAG or NTG eyes. There were no significant differences in oxygen saturation in venules or arteriovenous (AV) difference in all three glaucoma groups. Venular diameter was significantly reduced in all glaucoma groups compared to normal controls (P<0.001), but no such change was observed in arteriolar diameter (P=0.10). When comparing between eyes of asymmetrical glaucoma severity, arteriolar oxygen saturation (P=0.03) and AV difference (P=0.04) were significantly higher, while arteriolar diameter was significantly lower (P=0.001) in the worse eye in PACG group. There were no significant differences in oximetric parameters or vessel calibers between the worse and the better eyes in POAG and NTG groups. Conclusion Eyes with PACG showed increased arteriolar oxygen saturation and increased AV difference. This was not observed in POAG and NTG eyes. Arteriolar diameter in PACG and venular diameter in all three glaucoma groups were reduced. The difference observed in PACG eyes may be due to an increased

  16. Measurement of reed valve kinematics

    Directory of Open Access Journals (Sweden)

    Fenkl Michael

    2016-01-01

    Full Text Available The measurement of key kinematic parameters of a reed valve movement is necessary for the further development of the reed valve system. These parameters are dependent on the geometry and material properties of the valve. As they directly affect the quantity of air flowing around the valve, a simple and easy to implement measurement of various valve configuration based on the air flow has been devised and is described in this paper, along with its technical parameters and drawbacks when evaluating reed valves used in reciprocating air compressors. Results are presented for a specimen of a compressor under examination. All kinematic parameters, and timing of the opening and closing of the valve, obtained from the measurement are presented and discussed.

  17. Measurement of reed valve kinematics

    Science.gov (United States)

    Fenkl, Michael; Dvořák, Václav; Vít, Tomáš

    2016-03-01

    The measurement of key kinematic parameters of a reed valve movement is necessary for the further development of the reed valve system. These parameters are dependent on the geometry and material properties of the valve. As they directly affect the quantity of air flowing around the valve, a simple and easy to implement measurement of various valve configuration based on the air flow has been devised and is described in this paper, along with its technical parameters and drawbacks when evaluating reed valves used in reciprocating air compressors. Results are presented for a specimen of a compressor under examination. All kinematic parameters, and timing of the opening and closing of the valve, obtained from the measurement are presented and discussed.

  18. Present and New Treatment Strategies in the Management of Glaucoma

    DEFF Research Database (Denmark)

    Kolko, Miriam

    Glaucoma is a neurodegenerative disease characterized by retinal ganglion cell (RGC) death and axonal loss. It remains a major cause of blindness worldwide. All current modalities of treatment are focused on lowering intraocular pressure (IOP), and it is evident that increased IOP is an important...... risk factor for progression of the disease. However, it is clear that a significant number of glaucoma patients show disease progression despite of pressure lowering treatments. Much attention has been given to the development of neuroprotective treatment strategies, but the identification of such has...... been hampered by lack of understanding of the etiology of glaucoma. Hence, in spite of many attempts no neuroprotective drug has yet been clinically approved. Even though neuroprotection is without doubt an important treatment strategy, many glaucoma subjects are diagnosed after substantial loss of...

  19. Molecular complexity of primary open angle glaucoma: current concepts

    Indian Academy of Sciences (India)

    Kunal Ray; Suddhasil Mookherjee

    2009-12-01

    Glaucoma is a group of heterogeneous optic neuropathies with complex genetic basis. Among the three principle subtypes of glaucoma, primary open angle glaucoma (POAG) occurs most frequently. Till date, 25 loci have been found to be linked to POAG. However, only three underlying genes (Myocilin, Optineurin and WDR36) have been identified. In addition, at least 30 other genes have been reported to be associated with POAG. Despite strong genetic influence in POAG pathogenesis, only a small part of the disease can be explained in terms of genetic aberration. Current concepts of glaucoma pathogenesis suggest it to be a neurodegenerative disorder which is triggered by different factors including mechanical stress due to intra-ocular pressure, reduced blood flow to retina, reperfusion injury, oxidative stress, glutamate excitotoxicity, and aberrant immune response. Here we present a mechanistic overview of potential pathways and crosstalk between them operating in POAG pathogenesis.

  20. Latanoprost systemic exposure in pediatric and adult patients with glaucoma

    DEFF Research Database (Denmark)

    Raber, Susan; Courtney, Rachel; Maeda-Chubachi, Tomoko;

    2011-01-01

    To evaluate short-term safety and steady-state systemic pharmacokinetics (PK) of latanoprost acid in pediatric subjects with glaucoma or ocular hypertension who received the adult latanoprost dose....

  1. Afterword: Europe and the political geography of global confrontation. A world system perspective on Behind the War on Terror (N. Mosaddeq Ahmed)

    OpenAIRE

    Tausch, Arno

    2003-01-01

    Behind the War on Terror: Western Secret Strategy and the Struggle for Iraq by: Nafeez Mosaddeq Ahmed Manufacturer: Clairview Books Release Date: 23 June, 2003 Media: Paperback Sales Rank: 3,781 This afterword to this brilliant book starts from the assumption that both Europe and the Arab world are facing the same tendency of a basic and underlying shift in global economic activity away from the West of the Euro/Asian/African landmass towards the countries of the Pacific, and that the United ...

  2. Developments in mechanical heart valve prosthesis

    Indian Academy of Sciences (India)

    Kalyani Nair; C V Muraleedharan; G S Bhuvaneshwar

    2003-06-01

    Artificial heart valves are engineered devices used for replacing diseased or damaged natural valves of the heart. Most commonly used for replacement are mechanical heart valves and biological valves. This paper briefly outlines the evolution, designs employed, materials being used,. and important factors that affect the performance of mechanical heart valves. The clinical performance of mechanical heart valves is also addressed. Efforts made in India in the development of mechanical heart valves are also discussed.

  3. Videographic Assessment of Glaucoma Drop Instillation

    Science.gov (United States)

    Castillejos, Armando; Kahook, Malik; Jimenez-Roman, Jesus; Gonzalez-Salinas, Roberto

    2015-01-01

    ABSTRACT Purpose: To assess the effect of patient education on videotaped topical instillation of artificial tear drops on subsequent topical instillation. Materials and methods: Forty-five patients, who had been using glaucoma drops for at least 6 months and with a best-corrected visual acuity of 20/100 or better, were studied. The patients were asked to instill an artificial tear drop using their accustomed technique while being video recorded. The patients viewed the recordings, and the errors in their drop instillation method were pointed out. This was followed by an educational session on proper drop instillation technique. After 30 minutes, patients were videotaped instilling drops to ascertain the effect of the educational session. The variables compared were: number of drops instilled, number of drops reaching the ocular surface, and the number of times the tip of the medication bottle touched the eye or ocular adnexa. Results: Before the instruction session, patients squeezed an average of 1.5 ± 0.9 drops from the bottle, and the average number of drops reaching the conjunctival fornix was 0.9 ± 0.7. The tip of the bottle touched the ocular adnexa in 29/45 (64.4%) patients. After the education session, the patients squeezed an average of 1.2 ± 0.5 drops and an average of 1.2 ± 0.4 drops reached the conjunctival fornix. The tip of the bottle touched the ocular adnexa in 13/45 (28.9%) patients. With proper instructions, the percentage of patients that instilled just one drop on the eye increased from 66 to 82%. Conclusion: A single educational session on the proper use of topical drops improves the successful instillation of eye drops. However, it was not determined whether the patients will retain the improved instillation technique for long-term or if the intervention results in only a short-term improvement. How to cite this article: Lazcano-Gomez G, Castillejos A, Kahook M, Jimenez-Roman J, Gonzalez-Salinas R. Video-graphic Assessment of Glaucoma

  4. Patient-reported outcomes (PRO's) in glaucoma: a systematic review

    OpenAIRE

    Vandenbroeck, S; Geest, S. van der; Zeyen, T; Stalmans, I; Dobbels, F

    2011-01-01

    The aim of this review was to summarize literature in view of patient-reported outcome (PRO) instruments for glaucoma and provide guidance on how outcomes are best assessed based on evidence about their content and validity. A systematic literature review was performed on papers describing the developmental process and/or psychometric properties of glaucoma or vision-specific PRO-instruments. Each of them was assessed on their adherence to a framework of quality criteria. Fifty-three articles...

  5. Primary lens extraction for glaucoma management: A review article

    OpenAIRE

    Eid, Tarek M.

    2011-01-01

    Recently, primary lens extraction alone gained more acceptance as an alternative surgical approach for glaucoma management. This view was supported by the advances in phacoemulsification and intraocular lenses with greater safety and visual recovery, in addition to a substantial reduction of intraocular pressure and deepening of the anterior chamber and filtration angle. The decrease in IOP after cataract surgery in primary open-angle glaucoma (POAG) is mild, less predictable, related to base...

  6. Atypical Intrapapillary Hemorrhage in a Patient with Glaucoma

    Directory of Open Access Journals (Sweden)

    Sirel Gür Güngör

    2015-04-01

    Full Text Available A 73-year-old man presented for routine follow-up. There were primary open-angle glaucoma, diabetes mellitus, and usage of acetylsalicylic acid in patient’s history. Dilated fundus examination demonstrated cup hemorrhage in the right eye. Because of the progression of the superotemporal retinal nerve fiber layer defect in the last seven months, we think that the disk hemorrhage could be associated with glaucoma. (Turk J Ophthalmol 2015; 45: 77-8

  7. Atypical Intrapapillary Hemorrhage in a Patient with Glaucoma

    OpenAIRE

    Sirel Gür Güngör; Gülce Gökgöz Özışık; Ahmet Akman; Leyla Asena

    2015-01-01

    A 73-year-old man presented for routine follow-up. There were primary open-angle glaucoma, diabetes mellitus, and usage of acetylsalicylic acid in patient’s history. Dilated fundus examination demonstrated cup hemorrhage in the right eye. Because of the progression of the superotemporal retinal nerve fiber layer defect in the last seven months, we think that the disk hemorrhage could be associated with glaucoma. (Turk J Ophthalmol 2015; 45: 77-8)

  8. Vascular risk factors in primary open angle glaucoma

    OpenAIRE

    Belzunce, A. (Arnaldo); M. Casellas

    2004-01-01

    To determine whether cardiovascular risk factors distribution differ between primary open-angle glaucoma (POAG) and control subjects. To assess the strength of this association in POAG. To analyze the most frequent pathology in this group of patients for a better selection of medical treatment. METHODS: Observational cross-sectional study in patients with a diagnosis of POAG. Fifty glaucoma patients were selected with consecutive sampling between t...

  9. Current concepts in the diagnosis and management of developmental glaucomas

    OpenAIRE

    Mandal Anil

    1993-01-01

    Developmental glaucoma is a global problem and has a broad range of ocular manifestations and is sometimes associated with systemic disorders and syndromes. It poses a major diagnostic and management problem to the ophthalmologists. A proper diagnostic evaluation under general anesthesia is advisable for all children who do not cooperate for an office examination. Surgery remains the principal therapeutic modality in the management of developmental glaucoma and medical therapy is limited to a...

  10. Retrospective analysis of the risk factors for developing phacomorphic glaucoma

    Directory of Open Access Journals (Sweden)

    Jacky W Y Lee

    2011-01-01

    Full Text Available Aim : To determine the risk factors for developing phacomorphic glaucoma in eyes with mature cataracts. Materials and Methods : This is a case-control study comprising of 90 eyes with phacomorphic glaucoma and 90 age- and sex-matched control eyes with mature cataracts without phacomorphic glaucoma. Patients with pre-existing glaucoma, previous intraocular surgery and /or absence of documented axial lengths were excluded from this study. Binary logistic regression analysis of the variables, axial length and anterior chamber depth, was performed. Anterior chamber depth of the contralateral eye was used as a proxy measure of the pre-phacomorphic state in the eye with phacomorphic glaucoma as majority of them first presented to our center during the phacomorphic attack without prior measurements of the pre-phacomorphic ACD or lens thickness; therefore, their anterior chamber depth would not be representative of their pre-phacomorphic state. Axial length of 23.7 mm was selected as a cut-off for dichotomized logistic regression based on the local population mean from published demographic data. Results : The mean age was 73.1 ± 10.2 years. All phacomorphic and control eyes were ethnic Chinese. The mean presenting intraocular pressures were 49.5 ± 11.8 mmHg and 16.7 ± 1.7 mmHg in the phacomorphic and control eyes respectively (P 23.7 mm (P = 0.003. Conclusion : Axial length less than ≤ 23.7 mm was a risk factor for developing phacomorphic glaucoma. Eyes with AL shorter than the population mean were 4.3 times as likely to develop phacomorphic glaucoma compared with eyes with longer than average AL. In an area where phacomorphic glaucoma is prevalent and medical resources are limited, patients with AL shorter than their population mean may be considered for earlier elective cataract extraction as a preventive measure.

  11. Compliance with topical glaucoma medications in Owo, Nigeria.

    OpenAIRE

    BO OMOLASE; OA ADEOSUN; AK AKINWALERE; OA SOTILOYE; OT OGUNLEYE; CO OMOLASE

    2013-01-01

    Introduction: Poor compliance with medications is a major challenge in the management of primary open angle glaucoma as it can lead to deterioration of eyesight. This study assessed the compliance with glaucoma medications among patients attending an Eye Clinic in Nigeria. We also assessed the problems encountered during the applications of topical medications. Materials and Methods: This study was conducted over a period of one year (October 2011 to October 2012) at the Eye Clinic of the Fed...

  12. The next step: detailed assessment of an adult glaucoma patient

    Directory of Open Access Journals (Sweden)

    Matthew Burton

    2012-01-01

    Full Text Available The glaucomas are a group of progressive optic neuropathies associated with characteristic structural changes at the optic nerve head (cupping and corresponding visual field defects. The main modifiable risk factor for glaucomatous optic neuropathy is increased intraocular pressure (IOP. The aims of assessment are:accurate diagnosisidentification of the cause of increased IOP, if applicablequantification of the level of glaucoma damage and functional impairment.

  13. Teleglaucoma: Improving access and efficiency for glaucoma care

    OpenAIRE

    Faazil Kassam; Kanagasingam Yogesan; Enitan Sogbesan; Pasquale, Louis R.; Damji, Karim F

    2013-01-01

    Teleglaucoma is the application of telemedicine for glaucoma. We review and present the current literature on teleglaucoma; present our experience with teleglaucoma programs in Alberta, Canada and Western Australia; and discuss the challenges and opportunities in this emerging field. Teleglaucoma is a novel area that was first explored a little over a decade ago and early studies highlighted the technical challenges of delivering glaucoma care remotely. Advanced technologies have since emerge...

  14. Marijuana for Glaucoma: A Recipe for Disaster or Treatment?

    OpenAIRE

    Sun, Xiaoshen; Xu, Chaoying S.; Chadha, Nisha; Chen, Allshine; Liu, Ji

    2015-01-01

    Marijuana has been shown to lower intraocular pressure (IOP) but with limited duration of action and numerous adverse effects. Use of marijuana to lower IOP as a means of glaucoma treatment would require frequent use throughout the day, leading to significant adverse effects, possible progression toward Cannabis Use Disorder (CUD), and/or withdrawal symptoms. The treatment of glaucoma based on the cannabis plant or drugs based on the cannabinoid molecule should be considered carefully before ...

  15. Is Prevention of Glaucoma Possible in Bosnia and Herzegovina?

    Science.gov (United States)

    Terzic, Svjetlana; Jusufovic, Vahid; Vodencarevic, Amra Nadarevic; Asceric, Mensura; Pilavdzic, Adisa; Halilbasic, Meliha; Terzic, Amar

    2016-01-01

    Introduction: Glaucoma is the second leading cause of blindness in the world and represents a significant social and health problem. Early detection of glaucoma enables early initiation of treatment and may delay disease progression. The aim of this work is to determine whether it is possible to detect glaucoma in early stages. Methods: A public awareness campaign was carried out in University Clinic Center (UCC) in Tuzla, Bosnia and Herzegovina (B&H) during 2012, 2013, 2014 and 2015 Glaucoma Week, with one-day, free of charge screening of individuals. This screening program was composed of getting brief medical history, slit-lamp examination including intraocular pressure and anterior chamber dept evaluation and non-mydriatic fundus exam with evaluation of the cup/disk ration. Results: A total of 682 individuals were screened, 277 were male and 405 were female. The youngest individual was 8 years old and the oldest individual was 84 years old. The mean age was 57.6 years. Intraocular pressure higher then 21,9 mmHg was found in 83 patients. Conclusion: Glaucoma is a disease that affects visual acuity and gradually leads to blindness. It occurs in all age groups in both sexes and in all races. Early detection of disease and proper treatment can prevent permanent loss of vision. Detection and early treatment of glaucoma must become one of the leading public health programs in B&H. PMID:27147791

  16. Vascular considerations in glaucoma patients of African and European descent.

    Science.gov (United States)

    Huck, Andrew; Harris, Alon; Siesky, Brent; Kim, Nathaniel; Muchnik, Michael; Kanakamedala, Priyanka; Amireskandari, Annahita; Abrams-Tobe, Leslie

    2014-08-01

    Glaucoma is the leading cause of blindness in individuals of African descent (AD). While open-angle glaucoma (OAG) disproportionately affects individuals of AD compared with persons of European descent (ED), the physiological mechanisms behind this disparity are largely unknown. The more rapid progression and greater severity of the disease in persons of AD further raise the concern for identifying these underlying differences in disease pathophysiology between AD and ED glaucoma patients. Ocular structural differences between AD and ED patients, including larger optic disc area, cup:disc ratio and thinner corneas, have been found. AD individuals are also disproportionately affected by systemic vascular diseases, including hypertension, cardiovascular disease, stroke and diabetes mellitus. Abnormal ocular blood flow has been implicated as a risk factor for glaucoma, and pilot research is beginning to identify localized ocular vascular differences between AD and ED OAG patients. Given the known systemic vascular deficits and the relationship between glaucoma and ocular blood flow, exploring these concepts in terms of glaucoma risk factors may have a significant impact in elucidating the mechanisms behind the disease disparity in the AD population. PMID:24460758

  17. Eye Conditions in Older Adults: Open-Angle Glaucoma.

    Science.gov (United States)

    Iroku-Malize, Tochi; Kirsch, Scott

    2016-06-01

    Glaucoma is the leading cause of irreversible vision loss in the United States, affecting 1.9% of individuals older than 40 years. The prevalence of the most common form, open-angle glaucoma, increases with age and is higher in non-Hispanic minorities. The progressive loss of peripheral vision in glaucoma often leads to difficulty with driving, particularly at night, and can increase the risk of falls and subsequent fractures. Although glaucoma usually is characterized by chronically elevated intraocular pressure, it is more accurately defined as an optic neuropathy. Typically, there are no warning signs or symptoms, and extensive and permanent optic nerve damage can occur before the patient is aware of visual field loss. A cup to disc ratio greater than 0.6 on ophthalmoscopy is suspicious for glaucoma, and visual field testing results show a characteristic peripheral loss. Medical and surgical treatments are aimed at decreasing intraocular pressure by decreasing production of aqueous humor and increasing its outflow. Drugs for glaucoma treatment include prostaglandin analogs, beta blockers, alpha2-adrenergic agonists, and carbonic anhydrase inhibitors. Surgical or laser treatment is indicated if medical management is unsuccessful. Alternative therapies are less effective and have more adverse effects than standard treatments. PMID:27348527

  18. The Management of Secondary Glaucoma in Nanophthalmic Patients

    Institute of Scientific and Technical Information of China (English)

    Shengsong Huang; Minbin Yu; Changyu Qiu; Tiancai Ye

    2002-01-01

    Purpose: To investigate the clinical characteristcs, management of secondary glaucoma in nanophthalmos, and the prevention of its complications.Methods: Retrospectively, 9 cases (17 eyes) with nanophthalmic glaucoma were studied.Results: The axial length of the eyes ranged (14.36 ~ 19.33) mm; All of the cases combined with hyperopia ranged (+7.00~+16.00)D. All 17 eyes had the manifestation like angle-closure glaucoma.The glaucoma was controlled in 9 of 17 eyes at the early stage, which underwent laser iridotomy (4 of 9 eyes also underwent laser iridoplasty). 1 eye underwent ciliary photocoagulation because its visual acuity was lost and the patient complained of pain. The other 7 eyes underwent filtration surgery and 3 of them had permanent loss of vision caused by disastrous complications after the surgery.Conclusions: Management of secondary glaucoma in nanophthalmos is complicated. The laser iris surgery is safe and effective in glaucoma at the early stage. Vortex vein decompression, sclerotectomy or anterior sclerotomy may be performed to reduce disastrous complications.

  19. Emerging Concepts in Glaucoma and Review of the Literature.

    Science.gov (United States)

    Greco, Antonio; Rizzo, Maria Ida; De Virgilio, Armando; Gallo, Andrea; Fusconi, Massimo; de Vincentiis, Marco

    2016-09-01

    Glaucoma is the most commonly acquired optic neuropathy. It represents a public health challenge because it causes an irreversible blindness. Emerging evidence indicates that the pathogenesis of glaucoma depends on several interacting pathogenetic mechanisms, which include mechanical effects by an increased intraocular pressure, decreased neutrophine-supply, hypoxia, excitotoxicity, oxidative stress, and the involvement of autoimmune processes. In particular, alterations in serum antibody profiles have been described. However, it is still unclear whether the autoantibodies seen in glaucoma are an epiphenomenon or causative. Oxidative stress appears to be a critical factor in the neurodestructive consequences of mitochondrial dysfunction, glial activation response, and uncontrolled activity of the immune system during glaucomatous neurodegeneration. In addition, hearing loss has been identified in association with glaucoma. A higher prevalence of antiphosphatidylserine antibodies of the immunoglobulin G class was seen in normal-tension glaucoma patients with hearing loss in comparison with normal-tension glaucoma patients with normacusis. This finding suggests a similar pathological pathway as a sign for generalized disease. PMID:27125182

  20. Glaucoma detection based on local binary patterns in fundus photographs

    Science.gov (United States)

    Alsheh Ali, Maya; Hurtut, Thomas; Faucon, Timothée.; Cheriet, Farida

    2014-03-01

    Glaucoma, a group of diseases that lead to optic neuropathy, is one of the most common reasons for blindness worldwide. Glaucoma rarely causes symptoms until the later stages of the disease. Early detection of glaucoma is very important to prevent visual loss since optic nerve damages cannot be reversed. To detect glaucoma, purely data-driven techniques have advantages, especially when the disease characteristics are complex and when precise image-based measurements are difficult to obtain. In this paper, we present our preliminary study for glaucoma detection using an automatic method based on local texture features extracted from fundus photographs. It implements the completed modeling of Local Binary Patterns to capture representative texture features from the whole image. A local region is represented by three operators: its central pixel (LBPC) and its local differences as two complementary components, the sign (which is the classical LBP) and the magnitude (LBPM). An image texture is finally described by both the distribution of LBP and the joint-distribution of LBPM and LBPC. Our images are then classified using a nearest-neighbor method with a leave-one-out validation strategy. On a sample set of 41 fundus images (13 glaucomatous, 28 non-glaucomatous), our method achieves 95:1% success rate with a specificity of 92:3% and a sensitivity of 96:4%. This study proposes a reproducible glaucoma detection process that could be used in a low-priced medical screening, thus avoiding the inter-experts variability issue.

  1. Postoperative irradiation of glaucoma filtering surgery

    International Nuclear Information System (INIS)

    To inhibit the subcojunctival scarring after glaucoma filtering surgery, Sr-90 beta-irradiation of 10 Gy in 1 fraction or 20 Gy in 2 fractions has been tried in 12 eyes. Usual trabeculectomy followed by beta-irradiation was performed on 6 eyes. Of these, 3/6 eyes were meintained in normal range of IOP after irradiation. Furthermore, combined surgery of trabeculectomy, tenectomy and episcleral resection followed by beta-irradiation were performed on 6 eyes. Of these, 5/6 eyes were maintained in normal range of IOP. No complications was observed during 3 to 8 months of followup periods after treatment. Filtering surgery combined with postoperative beta-irradiation seems to inhibit the proliferation of subcon-junctival fibroblast and to control IOP. (1 Gy = 100 rad). (author)

  2. Impact of a Glaucoma Severity Index on Results of Trabectome Surgery: Larger Pressure Reduction in More Severe Glaucoma

    Science.gov (United States)

    Loewen, Ralitsa T.; Roy, Pritha; Parikh, Hardik A.; Dang, Yalong; Schuman, Joel S.; Loewen, Nils A.

    2016-01-01

    Purpose To stratify outcomes of trabectome-mediated ab interno trabeculectomy (AIT) by glaucoma severity using a simple and clinically useful glaucoma index. Based on prior data of trabectome after failed trabeculectomy, we hypothesized that more severe glaucoma might have a relatively more reduced facility compared to mild glaucoma and respond with a larger IOP reduction to trabecular meshwork ablation. Methods Patients with primary open angle glaucoma who had undergone AIT without any other same session surgery and without any second eye surgery during the following 12 months were analyzed. Eyes of patients that had less than 12 months follow up or were diagnosed with neovascular glaucoma were excluded. A glaucoma index (GI) was created to capture glaucoma severity based on visual field, number of preoperative medications, and preoperative IOP. Visual field (VF) was separated into 3 categories: mild, moderate, and advanced (assigned 1, 2, and 3 points, respectively). Preoperative number of medications (meds) was divided into 4 categories: ≤1, 2, 3 or ≥4, and assigned with a value of 1 to 4. Baseline IOP (IOP) was divided into 3 categories: 12–18 (Group 3) and >18 (Group 4). Linear regression was used to determine if there was an association between GI group and IOP reduction after one year or age, gender, race, diagnosis, cup to disc (C/D) ratio, and Shaffer grade. Results Out of 1340 patients, 843 were included in the analysis. The GI group distribution was GI1 = 164, GI2 = 202, GI3 = 260, and GI4 = 216. Mean IOP reduction after one year was 4.0±5.4, 6.4±5.8, 9.0±7.6, 12.0±8.0 mmHg for GI groups 1 to 4, respectively. Linear regression showed that IOP reduction was associated with GI group after adjusting for age, gender, race, diagnosis, cup to disc ratio, and Shaffer grade. Each GI group increase of 1 was associated with incremental IOP reductions of 2.95±0.29 mmHg. Success rate at 12 months was 90%, 77%, 77%, and 71% for GI groups 1 to 4. The log

  3. Glaucoma incidence in an unselected cohort of diabetic patients: is diabetes mellitus a risk factor for glaucoma?

    OpenAIRE

    Ellis, J.; Evans, J.; Ruta, D; Baines, P.; Leese, G; MacDonald, T; Morris, A

    2000-01-01

    AIMS—To evaluate whether diabetes mellitus is a risk factor for the development of primary open angle glaucoma or ocular hypertension (OHT).
METHODS—A historical cohort study of an unselected population comprising all residents of the Tayside region of Scotland was performed using record linkage techniques followed by case note review. Ascertainment of prevalent diabetes was achieved using the Diabetes Audit and Research in Tayside Study (DARTS) validated regional diabetes register. Glaucoma ...

  4. Valve actuator motor degradation

    International Nuclear Information System (INIS)

    Valve actuator motor degradation and failure has been a significant, but little studied, problem in the nuclear industry. This study provides a discussion of the primary failure mode --thermal degradation-- and reviews the basis for the solution to thermal degradation -- thermal protection. The study also provides reviews of various industry data bases, discusses effects of other failure modes such as corrosion, and provides a review of other considerations the user should entertain when assessing thermal protection

  5. Action plans for motor-operated valves and check valves

    International Nuclear Information System (INIS)

    The proper performance of motor-operated valves (MOVs) and check valves is necessary for the safety operation of a nuclear power plant. Problems have been experienced, however, with these valves for many years. Currently, the US Nuclear Regulatory Commission (NRC) and the nuclear industry have a number of activities under way to provide assurance that MOVs and check valves will successfully perform their safety functions when needed. The Mechanical Engineering Branch (EMEB) of the NRC Office of Nuclear Reactor Regulation has been assigned the responsibility of coordinating NRC activities and monitoring industry activities regarding MOVs and check valves. To meet this responsibility, EMEB has prepared action plans to provide assurance of the proper performance of these valves. Among the staff activities described in the action plans is the consideration of the need to revise the regulations to clarify the inservice testing (IST) requirements for these valves. The need for regulatory guidance for the development of acceptable IST programs, as well as for other licensee activities relating to the performance of MOVs and check valves, will also be evaluated. In addition, NRC personnel will have to verify, in a consistent manner, implementation of licensee commitments in response to NRC generic letters and bulletins. Another important aspect of the action plans is the provision for the NRC staff to provide assistance, where appropriate, to the industry in its efforts to address MOV and check valve issues. Finally, the action plans include a tentative schedule for accomplishing the described staff activities

  6. Valve studies: Hydrogen fluoride monitoring of UF6 cylinder valves

    International Nuclear Information System (INIS)

    Uranium hexafluoride (UF6) cylinder valves have, like the cylinders, been in use and/or storage for periods ranging from 15 to 44 years. Visual inspection of the cylinders has shown that the extent of corrosion and the overall cylinder condition varies widely throughout the storage yards. One area of concern is the integrity of the cylinder valves. Visual inspection has found deposits which have been identified as radioactive material on or near the valves. These deposits suggest leakage of UF6 and may indicate valve degradation; however, these deposits may simply be residual material from cylinder filling operations

  7. Performance Characteristics of an Isothermal Freeze Valve

    Energy Technology Data Exchange (ETDEWEB)

    Hailey, A.E.

    2001-08-22

    This document discusses performance characteristics of an isothermal freeze valve. A freeze valve has been specified for draining the DWPF melter at the end of its lifetime. Two freeze valve designs have been evaluated on the Small Cylindrical Melter-2 (SCM-2). In order to size the DWPF freeze valve, the basic principles governing freeze valve behavior need to be identified and understood.

  8. Semi-active compressor valve

    Science.gov (United States)

    Brun, Klaus; Gernentz, Ryan S.

    2010-07-27

    A method and system for fine-tuning the motion of suction or discharge valves associated with cylinders of a reciprocating gas compressor, such as the large compressors used for natural gas transmission. The valve's primary driving force is conventional, but the valve also uses an electromagnetic coil to sense position of the plate (or other plugging element) and to provide an opposing force prior to impact.

  9. Telocytes in human heart valves

    OpenAIRE

    Yang, Yang; Sun, Wei; Wu, Sean M; Xiao, Junjie; Kong, Xiangqing

    2014-01-01

    Valve interstitial cells (VICs) are responsible for maintaining the structural integrity and dynamic behaviour of the valve. Telocytes (TCs), a peculiar type of interstitial cells, have been recently identified by Popescu*s group in epicardium, myocardium and endocardium (visit http://www.telocytes.com). The presence of TCs has been identified in atria, ventricles and many other tissues and organ, but not yet in heart valves. We used transmission electron microscopy and immunofluorescence met...

  10. Awareness of and attitude towards glaucoma among an adult rural population of Osun State, Southwest Nigeria

    Directory of Open Access Journals (Sweden)

    Michaeline A Isawumi

    2014-01-01

    Conclusions: The outcomes of study indicate a low level of awareness of glaucoma. Health education at all levels of health and eye care services is required to prevent ocular morbidity and irreversible blindness from glaucoma.

  11. Innovative Stemless Valve Eliminates Emissions

    Science.gov (United States)

    2008-01-01

    Big Horn Valve Inc. (BHVI), of Sheridan, Wyoming, won a series of SBIR and Small Business Technology Transfer (STTR) contracts with Kennedy Space Center and Marshall Space Flight Center to explore and develop a revolutionary valve technology. BHVI developed a low-mass, high-efficiency, leak-proof cryogenic valve using composites and exotic metals, and had no stem-actuator, few moving parts, with an overall cylindrical shape. The valve has been installed at a methane coal gas field, and future applications are expected to include in-flight refueling of military aircraft, high-volume gas delivery systems, petroleum refining, and in the nuclear industry.

  12. Latest design of gate valves

    Energy Technology Data Exchange (ETDEWEB)

    Kurzhofer, U.; Stolte, J.; Weyand, M.

    1996-12-01

    Babcock Sempell, one of the most important valve manufacturers in Europe, has delivered valves for the nuclear power industry since the beginning of the peaceful application of nuclear power in the 1960s. The latest innovation by Babcock Sempell is a gate valve that meets all recent technical requirements of the nuclear power technology. At the moment in the United States, Germany, Sweden, and many other countries, motor-operated gate and globe valves are judged very critically. Besides the absolute control of the so-called {open_quotes}trip failure,{close_quotes} the integrity of all valve parts submitted to operational forces must be maintained. In case of failure of the limit and torque switches, all valve designs have been tested with respect to the quality of guidance of the gate. The guidances (i.e., guides) shall avoid a tilting of the gate during the closing procedure. The gate valve newly designed by Babcock Sempell fulfills all these characteristic criteria. In addition, the valve has cobalt-free seat hardfacing, the suitability of which has been proven by friction tests as well as full-scale blowdown tests at the GAP of Siemens in Karlstein, West Germany. Babcock Sempell was to deliver more than 30 gate valves of this type for 5 Swedish nuclear power stations by autumn 1995. In the presentation, the author will report on the testing performed, qualifications, and sizing criteria which led to the new technical design.

  13. Socioeconomics of long-term glaucoma therapy in India

    Directory of Open Access Journals (Sweden)

    Bhagabat Nayak

    2015-01-01

    Full Text Available Purpose: To determine the socioeconomic impact of long-term glaucoma therapy. Materials and Methods: One hundred and fifty consecutive glaucoma patients on medical therapy, following up at our glaucoma service for at least 6 months were recruited. A questionnaire regarding monthly income, cost of glaucoma medications prescribed, availability of medications, travel time, time spent in review clinics, compliance, education status, medical insurance and systemic or local side-effects was administered. Results: The patients seen at the tertiary government hospital had an average monthly income of Rs. 10,912/- (range: Rs. 500/- to Rs. 50,000/- with approximately 56% of the patients having an income of less than Rs. 5000/month. The expenditure on anti-glaucoma medications ranged from 0.3% in high income group to 123% of their monthly gross income in low income group (P < 0.0001. The total expenditure including travel, stay, and loss of wages of patients and accompanying persons ranged from 1.6% in high income group to 137% of the monthly income in low income group (P < 0.0001. Mean time required for a glaucoma clinic visit was 15.66 h, (range: 6-96 h/month. About 2.7% experienced systemic side-effects and 21.3% had complaints of ocular adverse effects. About 90% of the patients were compliant. 92% were not covered by any insurance plan/government reimbursement for their treatment. Conclusions: Medical therapy for glaucoma is an economic burden to many patients and should be individualized, according to the socioeconomic status, availability of drugs and the required distance to travel to reach the specialist clinics.

  14. Praktični pristop k obravnavi glavkoma: Practical approach to glaucoma management:

    OpenAIRE

    Cvenkel, Barbara

    2010-01-01

    Algorithms for management of glaucoma suspects and glaucoma patients are presented. After obtaining medical and ocular history, clinical examination and visual field testing a working diagnosis is established. Staging is assigned to glaucoma suspect according to the risk factors present and to glaucoma patients according to the severity of disease. The treatment is guided by the severity of disease, patientćs life expectancy, the state of thefellow eye, risk factors and presence of other syst...

  15. Eye drop administration in patients attending and not attending a glaucoma education center

    OpenAIRE

    Aisha Al-Busaidi; Debbie Anne Samek; Oscar Kasner

    2016-01-01

    Background: To assess the technique of glaucoma eye drop instillation in patients who have and have not attended glaucoma education sessions. To compare this with their subjective perception of eye drop use and identify factors associated with improved performance. Patients and Methods: An observational study of 55 participants who instill their topical glaucoma medication for more than 1 year. Twenty-five patients attended (A) glaucoma teaching sessions >1 year before the study and were ...

  16. Localised wedge shaped defects of the retinal nerve fibre layer in glaucoma.

    OpenAIRE

    Jonas, J. B.; Schiro, D

    1994-01-01

    Glaucoma can be associated with a diffuse or localised loss of the retinal nerve fibre layer (RNFL). This study evaluated the wedge shaped localised RNFL defects. Red free wide angle RNFL photographs of 421 patients with glaucoma and 193 normal subjects were examined. Localised RNFL defects were described for one eye of the normal group and for 20% of the patients with glaucoma. They were usually located in the inferior temporal and superior temporal fundus regions. Within the glaucoma group,...

  17. Low energy high pressure miniature screw valve

    Science.gov (United States)

    Fischer, Gary J.; Spletzer, Barry L.

    2006-12-12

    A low energy high pressure screw valve having a valve body having an upper portion and a lower portion, said lower portion of said valve body defining an inlet flow passage and an outlet flow passage traversing said valve body to a valve seat, said upper portion of said valve body defining a cavity at said valve seat, a diaphragm restricting flow between said upper portion of said valve body and said lower portion, said diaphragm capable of engaging said valve seat to restrict fluid communication between said inlet passage and said outlet passage, a plunger within said cavity supporting said diaphragm, said plunger being capable of engaging said diaphragm with said valve seat at said inlet and outlet fluid passages, said plunger being in point contact with a drive screw having threads engaged with opposing threads within said upper portion of said valve body such engagement allowing motion of said drive screw within said valve body.

  18. Whitey Gauge and Root Valves (VPS)

    Energy Technology Data Exchange (ETDEWEB)

    MISKA, C.

    2000-09-03

    These valves are 1/2 inch ball valves fabricated of 316 stainless steel: Packing is TFE (standard). They are used as isolation valves for pressure instrumentation in the Vacuum Pumping and Helium System.

  19. Aortitis requiring aortic repair associated with glaucoma, thyroiditis, glaucoma, and neuropathy: case report

    Directory of Open Access Journals (Sweden)

    Bayer Günther

    2011-05-01

    Full Text Available Abstract Aortitis may be due to infectious and non-infectious causes. We observed aortitis, associated with glaucoma, thyroiditis, pericarditis, pleural effusion and neuropathy in a 63-years old woman. Despite antibiotic therapy, inflammatory signs persisted and resolved only after initiation of glucocorticoid therapy. Increasing aortic ectasia necessitated resection of the ascending aorta and implantation of a Vascutek 30 mm prosthesis. Histologically a granulomatous aortitis was diagnosed. Since all other possible causes were excluded, an immunological mechanism of the aortitis is suspected and possible triggering factors are discussed.

  20. The Role of Systemic Arterial Stiffness in Open-Angle Glaucoma with Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Seong Hee Shim

    2015-01-01

    Full Text Available Purpose. To investigate the role of systemic arterial stiffness in glaucoma patients with diabetes mellitus (DM. Design. Retrospective, cross-sectional study. Participants. DM subjects who underwent brachial-ankle pulse wave velocity (baPWV were recruited. Methods. Glaucoma patients (n=75 and age-matched control subjects (n=92 were enrolled. Systemic examination including BaPWV and detailed eye examination were performed. The glaucoma group was divided into subgroups of normal tension glaucoma (NTG, n=55 and primary open-angle glaucoma (POAG based on an IOP of 21 mmHg. BaPWV was used to stratify the population into 4 groups based on the rate. Stepwise multiple logistic regression analysis by baPWV quartiles was used to compare the glaucoma group with the control group. Main Outcome Measures. BaPWV in glaucoma with DM patients. Results. Faster baPWV was positively associated with glaucoma (odds ratio: 3.74; 95% CI: 1.03–13.56, stepwise multiple logistic regression analysis in patients with DM. Increasing baPWV was also positively associated with glaucoma (p for trend = 0.036. The NTG subgroup showed similar results to those of the glaucoma group. Conclusions. In this study, increased arterial stiffness was shown to be associated with glaucoma and may contribute to the pathogenesis of glaucoma in DM patients.

  1. Characteristics of respondents with glaucoma and dry eye in a national panel survey

    Directory of Open Access Journals (Sweden)

    Jordana K Schmier

    2009-11-01

    Full Text Available Jordana K Schmier1, David W Covert21Exponent Inc., Alexandria, VA, USA; 2Alcon Research, Ltd., Fort Worth, TX, USABackground: There is an increasing body of evidence strongly suggesting that glaucoma medications may contribute to ocular surface disease and development of dry eye.Objective: To identify glaucoma patients with dry eye, using a nationally representative sample, and to compare clinical and treatment characteristics with controls without dry eye. Methods: Patients taking intraocular pressure-lowering medications were identified from the Medical Expenditure Panel Survey. A matched cohort without glaucoma served as controls. Dry eye was identified by diagnosis or use of prescription or over-the-counter medications. Demographic and clinical characteristics and medication use patterns were compared. Results: The analysis identified 629 respondents with glaucoma and 6,934 controls without glaucoma. Dry eye was more common among glaucoma respondents than nonglaucoma controls (16.5% vs 5.6%, P < 0.0001. There was a nonsignificant trend for respondents with dry eye to report higher rates of glaucoma adjunctive therapy use compared to those without dry eye (44.2% vs 35.0%, P < 0.076. Prostaglandin analogs were the most common glaucoma medication.Conclusions: This analysis found that the rate of dry eye was higher in patients with glaucoma than in controls. The use of glaucoma adjunctive therapies may increase the rate of dry eye in glaucoma patients.Keywords: dry eye syndromes, health care surveys, glaucoma

  2. Incidence and risk factors of open-angle glaucoma : the Rotterdam study

    NARCIS (Netherlands)

    S. de Voogd (Simone); A. Hofman (Albert)

    2006-01-01

    markdownabstract__Abstract__ Glaucoma is one of the poorest understood and defined eye diseases among those known since our era. Despite two millennia of writing about glaucoma, a straightforward and clear-cut definition is not available worldwide. In essence, glaucoma is an eye disease characteriz

  3. Estimated Prevalence of Glaucoma in South Korea Using the National Claims Database

    Directory of Open Access Journals (Sweden)

    Sang Jin Seo

    2016-01-01

    Full Text Available Purpose. To estimate the prevalence of glaucoma and costs associated with glaucoma care in South Korea between 2008 and 2013 using the Korean national claims database. Design. Retrospective cross-sectional study from a national claims database. Methods. Patients who were diagnosed with glaucoma between 2008 and 2013 were retrospectively identified in the national claims database using glaucoma diagnostic codes. For each year, the prevalence of glaucoma and direct medical costs associated with glaucoma care were estimated. Result. The prevalence of glaucoma in patients ≥40 years of age increased from 0.79% in 2008 to 1.05% in 2013. The number of patients with glaucoma increased by 54% between 2008 and 2013 (9% average annual increase. The prevalence of glaucoma increased with age and was higher in males than in females. The cost to care for glaucoma patients increased from $16.5 million in 2008 to $29.2 million in 2013, which translated into an 81% increase over the 6 years examined (12.7% average annual increase. Conclusion. The estimated prevalence and socioeconomic burden of glaucoma have steadily increased each year in South Korea. Nevertheless, many glaucoma patients remain undiagnosed in the present study using national claims database.

  4. Safety relief valve instabilities

    International Nuclear Information System (INIS)

    The opening and closing of safety relief valves induce pressure vibrations and respective loads on the piping system. The quantification of the internal pressure load and the pipe segment forces for the proof of the structural integrity of the piping system and the supports is performed using the code DYVRO. It is not clear whether the calculated result of high-frequent opening and closing shows a realistic behavior or is caused by a simplified modeling. The contribution offers strategic recommendations to avoid unrealistic calculations.

  5. High Reliability Cryogenic Piezoelectric Valve Actuator Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Cryogenic fluid valves are subject to harsh exposure and actuators to drive these valves require robust performance and high reliability. DSM's piezoelectric...

  6. Brain MRI findings in infants with primary congenital glaucoma

    International Nuclear Information System (INIS)

    Congenital glaucoma appears in the first months of life, eventually at birth. Isolated congenital glaucoma is characterized by minor malformations of the irido-corneal angle of the anterior chamber of the eye. Clinical manifestations include tearing, photophobia and enlargement of the globe appearing in the first months of life. Imaging technology such as optical coherence tomography and measurement of central corneal thickness may play an important role in the assessment of children with suspected or known glaucoma. However, no MRI findings of the CNS in patients with primary congenital glaucoma (PCG) were reported in the literature. The purpose of this study was to investigate MRI findings of the brain in infants with PCG. We reviewed the radiological and histopathological and clinical characteristics of infants with primary congenital glaucoma. The records of 17 patients with PCG were reviewed and the MRIs of the brain and associated manifestations were analyzed. Three patients with PCG had abnormal MRI findings suggesting agenesis of the corpus callosum. Two infants had delayed myelinization of the brain. Significant abnormal optic nerve excavation and increased corneal diameters in 2 patients with delayed myelinization may suggest that intraocular pressure can be more striking and more severe, revealing a close relationship with PCG and abnormal myelinization in white matter. Studies with more patients are needed to confirm these results. (author)

  7. Valve replacement at Calvert Cliffs

    International Nuclear Information System (INIS)

    This article describes how new valves helped solve plant's chronic salt water system problems resulting from years of design changes required by regulations that resulted in operational efficiency-related problems. The topics of the article include harsh service conditions (salt water related corrosion, biological fouling and tearing of rubber liners of valves), spare parts headaches and the permanent solution

  8. What Causes Heart Valve Disease?

    Science.gov (United States)

    ... other infections with strep bacteria that progress to rheumatic fever can cause heart valve disease. When the body tries to fight the strep ... you feel better before the medicine is gone. Heart valve disease caused by rheumatic fever mainly affects older adults who had strep ...

  9. Minimally Invasive Aortic Valve Replacement

    Medline Plus

    Full Text Available ... Terry asks if you do robotic valve replacement surgeries. I do not. It's a good question. You know, there's a handful of surgeons, frankly, in the world that I think do enough robotic cardiac surgery, whether it be valve surgery or coronary bypass ...

  10. Variable gas leak rate valve

    Science.gov (United States)

    Eernisse, Errol P.; Peterson, Gary D.

    1976-01-01

    A variable gas leak rate valve which utilizes a poled piezoelectric element to control opening and closing of the valve. The gas flow may be around a cylindrical rod with a tubular piezoelectric member encircling the rod for seating thereagainst to block passage of gas and for reopening thereof upon application of suitable electrical fields.

  11. Minimally Invasive Aortic Valve Replacement

    Medline Plus

    Full Text Available ... valve in the aortic position will grow over time and proves a nice replacement. However, that's sort of operating on two valves to fix one valvular problem. And for most patients in our practice in their 50s, 60s, et cetera, we tend ...

  12. Glaucoma secundario a neurofibromatosis tipo-1

    Directory of Open Access Journals (Sweden)

    Anay Martínez Díaz

    2012-02-01

    Full Text Available Paciente de 59 años de edad, con antecedentes de neurofibromatosis tipo 1 y trauma contuso del ojo derecho desde hace años. Acudió a consulta de oftalmología refiriendo disminución lenta de la visión; al examen físico se constató una agudeza visual de 0.6 en ambos ojos, así como disminución concéntrica del campo visual en la perimetría por confrontación. El examen objetivo mostró en los anexos una pingüécula en ojo derecho y pterigion grado II en ojo izquierdo; en segmento anterior, múltiples nódulos de Lisch en el iris de ambos ojos, y en el ojo derecho, pupila ligeramente midriática, pero reactiva. Se le realizó gonoscopia, oftalmoscopia y perimetría Humphry; en esta última se halló un escotoma arqueado en ojo derecho, y un defecto superior arqueado en el ojo izquierdo. Se concluyó el caso con los diagnósticos de catarata presenil incipiente y glaucoma secundario a neurofibromatosis tipo 1.

  13. Purtscher's retinopathy followed by neovascular glaucoma

    Directory of Open Access Journals (Sweden)

    Kuroda M

    2013-11-01

    Full Text Available Masasko Kuroda,1 Akihiro Nishida,1 Masashi Kikuchi,2 Yasuo Kurimoto11Department of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan; 2Kikuchi Eye Clinic, Kobe, Hyogo, JapanAbstract: We report the case of a 66-year-old Japanese man who developed neovascular glaucoma secondary to Purtscher's retinopathy following a head injury. The patient presented at our hospital with blurred vision and a visual field abnormality in his left eye 1 month after suffering from a head injury. Upon initial presentation, his best-corrected visual acuity on a decimal chart was 1.5 oculus dexter and 0.6 oculus sinister. The intraocular pressure (IOP was 12 mmHg in both eyes. Fundus examination of the left eye revealed multiple white lesions in the posterior pole. Optical coherence tomography demonstrated retinal edema, particularly in the inner retina. On the basis of these findings, a diagnosis of Purtscher's retinopathy was made. One month after the initial examination, the visual acuity in the left eye deteriorated to 0.01 in decimal chart, and the IOP increased to 37 mmHg. Gonioscopy showed angle neovascularization. The patient received an intravitreal bevacizumab injection and panretinal photocoagulation. Subsequently, the IOP normalized and the angle neovascularization regressed.Keywords: blurred vision, visual field, retinal edema, head injury, head trauma

  14. Ocular Blood Flow and Normal Tension Glaucoma

    Directory of Open Access Journals (Sweden)

    Ning Fan

    2015-01-01

    Full Text Available Normal tension glaucoma (NTG is known as a multifactorial optic neuropathy characterized by progressive retinal ganglion cell death and glaucomatous visual field loss, even though the intraocular pressure (IOP does not exceed the normal range. The pathophysiology of NTG remains largely undetermined. It is hypothesized that the abnormal ocular blood flow is involved in the pathogenesis of this disease. A number of evidences suggested that the vascular factors played a significant role in the development of NTG. In recent years, the new imaging techniques, fluorescein angiography, color Doppler imaging (CDI, magnetic resonance imaging (MRI, and laser speckle flowgraphy (LSFG, have been used to evaluate the ocular blood flow and blood vessels, and the impaired vascular autoregulation was found in patients with NTG. Previous studies showed that NTG was associated with a variety of systemic diseases, including migraine, Alzheimer’s disease, primary vascular dysregulation, and Flammer syndrome. The vascular factors were involved in these diseases. The mechanisms underlying the abnormal ocular blood flow in NTG are still not clear, but the risk factors for glaucomatous optic neuropathy likely included oxidative stress, vasospasm, and endothelial dysfunction.

  15. Glaucoma Therapy: Prescribing Pattern and Cost Analysis

    Directory of Open Access Journals (Sweden)

    Rashmi Sharma, Ruchi Khajuria, Pushpinder Sharma, P. Sadhotra, B. Kapoor, K. Kohli, C.L. Sharma

    2004-04-01

    Full Text Available In the present study out of total 200 prescriptions of POAG (primary open angle glaucoma studied66% were found to be of monotherapy including timolol, brimonidine, pilocarpine, betaxolol, levobunolol,latanoprost and apraclonidine in 30%, 15 %, 6%, 8% , 4%, 1% and 2% of the prescriptions respectivelyand 34% were found to be of polypharmacy with timolol+pilocarpine, timolol+acetazolamide, timolol+brimonidine and betaxolol+brimonidine in 13%, 4%, 8% and 9% of the prescriptions respectively.10% drugs were prescribed by generic name. Written instruction to the patients regarding dose anddosing interval was mentioned in 100% prescriptions, but the proper method of instillation wasmentioned only in 15% of the prescriptions. Results of the present study clearly indicated urgentneed for prescribers to improve their communication skills, to give proper instructions to the patientregarding instillation of drug, as little bit of caution like instillation from the side of the eye in thesupine position followed by rolling of the eyeball can decrease the wastage, decrease cost andimprove compliance. However, in the present scenario cost of the traditional medications like betablockers,pilocarpine etc. is found to be much less than newer medications (prostaglandin analogues,brimonidine. Moreover, in presence of wide cost variation among various brands of the same drugour study could help the opthalmologist to use all possible measures of pharmacoeconomics whileprescribing an antiglaucoma drug.

  16. Quality team approach to valve reliability

    International Nuclear Information System (INIS)

    In mid-1985, due to the unacceptable failure of valves, a commitment was made to implement a comprehensive valve improvement program at Duke Power Company (DPC). To accomplish an immediate, significant improvement in the quality of valve maintenance execution, a system to provide additional detailed engineering and technical support to the individual valve maintenance crews was first developed and utilized at the Oconee nuclear station in the fall of 1985. This system was later implemented at the other two DPC nuclear stations. The total number of valves on the seven nuclear units is ∼ 140,000. With such a large number of valves, even a small percentage of problem valves can have a major impact on unit availability. Other long-range improvements, such as replacement of selected problem valves and improved, valve-specific training for dedicated valve crews, will ensure even higher valve and station reliability in the future

  17. Monochromatic Pupillometry in Unilateral Glaucoma Discloses no Adaptive Changes Subserved by the ipRGCs

    DEFF Research Database (Denmark)

    Nissen, Claus; Sander, Birgit Agnes; Milea, Dan; Kolko, Miriam; Herbst, Kristina; Hamard, Pascale; Lund-Andersen, Henrik

    2014-01-01

    PURPOSE: To detect signs of a possible adaptive mechanism of the intrinsically photosensitive ganglion cells in unilateral glaucoma. METHOD: Eleven patients with unilateral glaucoma, classified by automated perimetry (glaucoma: mean deviation <0), were studied by monochromatic pupillometry...... in the glaucomatous eyes of unilateral glaucoma. No difference was detected between the pupillary light response of the unafflicted fellow eyes and that of a healthy, age-matched control group. Thus no sign of an adaptive mechanism was detected, neither in the glaucomatous nor in the unafflicted...... fellow eyes, and consequently glaucoma appears to differ from non-arteritic anterior ischemic optic neuropathy....

  18. Automated Classification of Glaucoma Images by Wavelet Energy Features

    Directory of Open Access Journals (Sweden)

    N.Annu

    2013-04-01

    Full Text Available Glaucoma is the second leading cause of blindness worldwide. As glaucoma progresses, more optic nerve tissue is lost and the optic cup grows which leads to vision loss. This paper compiles a systemthat could be used by non-experts to filtrate cases of patients not affected by the disease. This work proposes glaucomatous image classification using texture features within images and efficient glaucoma classification based on Probabilistic Neural Network (PNN. Energy distribution over wavelet sub bands is applied to compute these texture features. Wavelet features were obtained from the daubechies (db3, symlets (sym3, and biorthogonal (bio3.3, bio3.5, and bio3.7 wavelet filters. It uses a technique to extract energy signatures obtained using 2-D discrete wavelet transform and the energy obtained from the detailed coefficients can be used to distinguish between normal and glaucomatous images. We observedan accuracy of around 95%, this demonstrates the effectiveness of these methods.

  19. Phacoemulsification in Patients with Secondary Glaucoma Caused by Uveitis

    Institute of Scientific and Technical Information of China (English)

    Mingkai Lin; Jian Ge; Yizhi Liu; Yuqing Lan; Yehong Zhou

    2001-01-01

    Purposes: To evaluate the effect of phacoemulsification in the patients with uveitis,secondary glaucoma and complicated cataract. Methods: Phacoemulsification and implantation of a foldable intraocular len was performed in 12 patients(13 eyes) with uveitis, secondary glaucoma and complicated cataract. The complications, intraocular pressures (IOP), and visual acuity were observed postoperatively. Results: No severe complication was found in the patients postoperatively or within the operation procedure. The visual acuity was improved after the operation ( P < 0.05) .The intraocular pressures and/or the number of antiglaucoma medications reduced in 3months of the follow-up time. Conclusion: phacoemulsification is the best way to treat the patients with secondary glaucoma and complicated cataract caused by uveitis. Eye Science 2001; 17: 8 ~ 10.

  20. Vascular Dysfunction in Diabetes and Glaucoma: A Complex Relationship Reviewed.

    Science.gov (United States)

    Gerber, Austin L; Harris, Alon; Siesky, Brent; Lee, Eric; Schaab, Tara J; Huck, Andrew; Amireskandari, Annahita

    2015-08-01

    Open-angle glaucoma (OAG) is a multifactorial disease characterized by progressive retinal ganglion cell death and visual field loss. Intraocular pressure, ocular perfusion pressure, and systemic vascular irregularities have all been identified as contributing factors for glaucoma onset and progression. Focal and systemic vascular abnormalities have also been well documented in diabetic patients. The relationship between diabetes mellitus and OAG remains enigmatic in the literature. As the pathogenesis of both diabetes mellitus and OAG involves compromised vascular regulation, this review was undertaken to further investigate their precise relationship. A literature review of published population-based studies was performed, with a focus on studies regarding blood flow abnormalities. Although current studies support the role of vascular contributions to both diseases, the association between glaucoma and diabetes yields contrasting results. PMID:25264988

  1. Teleglaucoma: improving access and efficiency for glaucoma care.

    Science.gov (United States)

    Kassam, Faazil; Yogesan, Kanagasingam; Sogbesan, Enitan; Pasquale, Louis R; Damji, Karim F

    2013-01-01

    Teleglaucoma is the application of telemedicine for glaucoma. We review and present the current literature on teleglaucoma; present our experience with teleglaucoma programs in Alberta, Canada and Western Australia; and discuss the challenges and opportunities in this emerging field. Teleglaucoma is a novel area that was first explored a little over a decade ago and early studies highlighted the technical challenges of delivering glaucoma care remotely. Advanced technologies have since emerged that show great promise in providing access to underserviced populations. Additionally, these technologies can improve the efficiency of healthcare systems burdened with an increasing number of patients with glaucoma, and a limited supply of ophthalmologists. Additional benefits of teleglaucoma systems include e-learning and e-research. Further work is needed to fully validate and study the cost and comparative effectiveness of this approach relative to traditional models of healthcare. PMID:23741133

  2. Teleglaucoma: Improving access and efficiency for glaucoma care

    Directory of Open Access Journals (Sweden)

    Faazil Kassam

    2013-01-01

    Full Text Available Teleglaucoma is the application of telemedicine for glaucoma. We review and present the current literature on teleglaucoma; present our experience with teleglaucoma programs in Alberta, Canada and Western Australia; and discuss the challenges and opportunities in this emerging field. Teleglaucoma is a novel area that was first explored a little over a decade ago and early studies highlighted the technical challenges of delivering glaucoma care remotely. Advanced technologies have since emerged that show great promise in providing access to underserviced populations. Additionally, these technologies can improve the efficiency of healthcare systems burdened with an increasing number of patients with glaucoma, and a limited supply of ophthalmologists. Additional benefits of teleglaucoma systems include e-learning and e-research. Further work is needed to fully validate and study the cost and comparative effectiveness of this approach relative to traditional models of healthcare.

  3. Neovascular glaucoma after helium ion irradiation for uveal melanoma

    International Nuclear Information System (INIS)

    Neovascular glaucoma developed in 22 of 169 uveal melanoma patients treated with helium ion irradiation. Most patients had large melanomas; no eyes containing small melanomas developed anterior segment neovascularization. The mean onset of glaucoma was 14.1 months (range, 7-31 months). The incidence of anterior segment neovascularization increased with radiation dosage; there was an approximately three-fold increase at 80 GyE versus 60 GyE of helium ion radiation (23% vs. 8.5%) (P less than 0.05). Neovascular glaucoma occurred more commonly in larger tumors; the incidence was not affected by tumor location, presence of subretinal fluid, nor rate of tumor regression. Fifty-three percent of patients had some response with intraocular pressures of 21 mmHg or less to a combination of antiglaucoma treatments

  4. Natural therapies for ocular disorders, part two: cataracts and glaucoma.

    Science.gov (United States)

    Head, K A

    2001-04-01

    Pathophysiological mechanisms of cataract formation include deficient glutathione levels contributing to a faulty antioxidant defense system within the lens of the eye. Nutrients to increase glutathione levels and activity include lipoic acid, vitamins E and C, and selenium. Cataract patients also tend to be deficient in vitamin A and the carotenes, lutein and zeaxanthin. The B vitamin riboflavin appears to play an essential role as a precursor to flavin adenine dinucleotide (FAD), a co-factor for glutathione reductase activity. Other nutrients and botanicals, which may benefit cataract patients or help prevent cataracts, include pantethine, folic acid, melatonin, and bilberry. Diabetic cataracts are caused by an elevation of polyols within the lens of the eye catalyzed by the enzyme aldose reductase. Flavonoids, particularly quercetin and its derivatives, are potent inhibitors of aldose reductase. Glaucoma is characterized by increased intraocular pressure (IOP) in some but not all cases. Some patients with glaucoma have normal IOP but poor circulation, resulting in damage to the optic nerve. Faulty glycosaminoglycan (GAG) synthesis or breakdown in the trabecular meshwork associated with aqueous outflow has also been implicated. Similar to patients with cataracts, those with glaucoma typically have compromised antioxidant defense systems as well. Nutrients that can impact GAGs such as vitamin C and glucosamine sulfate may hold promise for glaucoma treatment. Vitamin C in high doses has been found to lower IOP via its osmotic effect. Other nutrients holding some potential benefit for glaucoma include lipoic acid, vitamin B12, magnesium, and melatonin. Botanicals may offer some therapeutic potential. Ginkgo biloba increases circulation to the optic nerve; forskolin (an extract from Coleus forskohlii) has been used successfully as a topical agent to lower IOP; and intramuscular injections of Salvia miltiorrhiza have shown benefit in improving visual acuity and

  5. Self-Rupturing Hermetic Valve

    Science.gov (United States)

    Tucker, Curtis E., Jr.; Sherrit, Stewart

    2011-01-01

    For commercial, military, and aerospace applications, low-cost, small, reliable, and lightweight gas and liquid hermetically sealed valves with post initiation on/off capability are highly desirable for pressurized systems. Applications include remote fire suppression, single-use system-pressurization systems, spacecraft propellant systems, and in situ instruments. Current pyrotechnic- activated rupture disk hermetic valves were designed for physically larger systems and are heavy and integrate poorly with portable equipment, aircraft, and small spacecraft and instrument systems. Additionally, current pyrotechnically activated systems impart high g-force shock loads to surrounding components and structures, which increase the risk of damage and can require additional mitigation. The disclosed mechanism addresses the need for producing a hermetically sealed micro-isolation valve for low and high pressure for commercial, aerospace, and spacecraft applications. High-precision electrical discharge machining (EDM) parts allow for the machining of mated parts with gaps less than a thousandth of an inch. These high-precision parts are used to support against pressure and extrusion, a thin hermetically welded diaphragm. This diaphragm ruptures from a pressure differential when the support is removed and/or when the plunger is forced against the diaphragm. With the addition of conventional seals to the plunger and a two-way actuator, a derivative of this design would allow nonhermetic use as an on/off or metering valve after the initial rupturing of the hermetic sealing disk. In addition, in a single-use hermetically sealed isolation valve, the valve can be activated without the use of potential leak-inducing valve body penetrations. One implementation of this technology is a high-pressure, high-flow-rate rupture valve that is self-rupturing, which is advantageous for high-pressure applications such as gas isolation valves. Once initiated, this technology is self

  6. Epidemiology and clinical characteristics of patients with glaucoma: An analysis of hospital data between 2003 and 2012

    OpenAIRE

    Yang Zhao; Jia-Li Fu; Yu-Li Li; Ping Li; Feng-Lan Lou

    2015-01-01

    Purpose: To assess demographic and clinical characteristics of glaucoma patients in an Ophthalmologic Hospital of Jinan, China from 2003 to 2012. Materials and Methods: Medical charts of patients with primary open-angle glaucoma (POAG), primary angle closure glaucoma (PACG), and secondary glaucoma (SG) were reviewed. The main outcome measures of patients with glaucoma included basic demographic data (age at presentation, gender, and residence), clinical characteristics (admission date, intrao...

  7. Giant Thoracic Aneurysm Following Valve Replacement for Bicuspid Aortic Valve.

    Science.gov (United States)

    Tran, Cao; Ul Haq, Ehtesham; Nguyen, Ngoc; Omar, Bassam

    2015-01-01

    Bicuspid aortic valve is a common congenital anomaly associated with aortopathy, which can cause aortic root dilatation, necessitating regular screening if the aortic root is > 4.0 cm. Despite the low absolute incidence of aortic complications associated with bicuspid aortic valve in the general population, the consequences of such complications for an individual patient can be devastating. Herein we propose a balanced algorithm that incorporates recommendations from the three major guidelines for follow-up imaging of the aortic root and ascending thoracic aorta in patients with a bicuspid aortic valve, maintaining the current recommendations with regard to surgical thresholds. PMID:26827748

  8. Systems of imaging digital systems in case of glaucoma

    International Nuclear Information System (INIS)

    Now a day we can't consider the strict follow up in Glaucoma without the use of the digital analysis of image system of the optic nerve head and the retinal nerve fiber layer. This is a review about some contributions of Scanning Laser Polarimetry (GDx VCC, Carl Zeiss Meditec, Dublin, CA), Confocal Scanning Laser (Heidelberg Retina Tomograph HRT, Heidelberg Engineering Inc.) and Optical Coherence Tomography (Stratus OCT, Carl Zeiss Meditec, Alemania) in the diagnosis and follow up of Glaucoma. It's considered that objective measurement giving by them must be incorporate in the rigorous analysis of each glaucomatous patient

  9. Geleophysic dysplasia associated with bilateral angle closure glaucoma

    Directory of Open Access Journals (Sweden)

    Murat Sinan Saricaoglu

    2013-01-01

    Full Text Available In this case report, we present occurrence of bilateral angle closure glaucoma in a 9-year-old girl with geleophysic dysplasia. Bilateral YAG laser iridotomy was applied, but intraocular pressure (IOP remained at high levels, necessitating bilateral trabeculectomy with mitomycin C. On her follow-up examinations for 3 years, IOP remained in the mid-20s with no need for further intervention or antiglaucoma medication. There are few reports describing the ocular findings of geleophysic dysplasia in literature. To our knowledge, this is the first case report describing an application of glaucoma surgery and its results at geleophysic dysplasia.

  10. [Research about surgical treatment in primary congenital glaucoma].

    Science.gov (United States)

    Catrinu, Lilia; Vancea, Petre P

    2005-01-01

    The aim of this investigation was the research of different types of surgical treatments applied to the early primary congenital glaucoma, and the identification of the best and most efficient therapies for each individual. It is a retrospective research on a number of 74 eyes with early primary congenital glaucoma, who were diagnosed and had an operation during the first four years from birth, since 1990 to March 2004, in 6 hospital centres from Romania. There were 101 surgical operation, the most frequent surgical methods used were trabeculotomy and trabeculectomy, which produce similar effects. PMID:16245746

  11. The Prevalence and Incidence of Glaucoma in Denmark in a Fifteen Year Period

    DEFF Research Database (Denmark)

    Kolko, Miriam; Horwitz, Anna; Thygesen, John; Jeppesen, Jorgen; Torp-Pedersen, Christian

    2015-01-01

    PURPOSE: The purpose of the present study was to describe the prevalence, incidence and geographic variation of glaucoma in Denmark in the period from 1996 to 2011. Moreover, the aim was to identify the treatment patterns of glaucoma within the studied period. METHODS: All Danish citizens were...... included throughout the study period. The National Prescription Registry was used to identify all claimed prescriptions for glaucoma medication. RESULTS: A total of 116,592 incident glaucoma patients were identified. Average age at onset was 66 years (range: 0-105 years), 55% were women. The prevalence of...... glaucoma increased from 0.79% to 1.72% during the investigated period. In 2011 glaucoma affected 3.76% of the population above 50 years and 10% in patients above 80 years. The age-specific incidence rate of glaucoma seemed to be constant and the increasing prevalence was primarily attributed to an aging...

  12. Twenty-Two-Year Experience with Aortic Valve Replacement: Starr-Edwards Ball Valves versus Disc Valves

    OpenAIRE

    Pilegaard, Hans K.; Lund, Ole; Nielsen, Torsten T; Magnussen, Karin; Knudsen, Mary A; Albrechtsen, Ole K.

    1991-01-01

    From 1965 through 1986, 817 patients underwent aortic valve replacement at our institution. Six hundred forty-five patients received Starr-Edwards ball valves, including 286 Silastic ball valves (Models 1200/1260), 165 cloth-covered caged-ball prostheses (Models 2300/2310/2320), and 194 track-valve prostheses (Model 2400). In contrast, 172 patients received disc-valve prostheses, including 126 St. Jude Medical aortic bi-leaflet disc valves, 32 Lillehei-Kaster pivoting disc valves, and 14 Björ...

  13. Cavitation guide for control valves

    Energy Technology Data Exchange (ETDEWEB)

    Tullis, J.P. [Tullis Engineering Consultants, Logan, UT (United States)

    1993-04-01

    This guide teaches the basic fundamentals of cavitation to provide the reader with an understanding of what causes cavitation, when it occurs, and the potential problems cavitation can cause to a valve and piping system. The document provides guidelines for understanding how to reduce the cavitation and/or select control valves for a cavitating system. The guide provides a method for predicting the cavitation intensity of control valves, and how the effect of cavitation on a system will vary with valve type, valve function, valve size, operating pressure, duration of operation and details of the piping installation. The guide defines six cavitation limits identifying cavitation intensities ranging from inception to the maximum intensity possible. The intensity of the cavitation at each limit Is described, including a brief discussion of how each level of cavitation influences the valve and system. Examples are included to demonstrate how to apply the method, including making both size and pressure scale effects corrections. Methods of controlling cavitation are discussed providing information on various techniques which can be used to design a new system or modify an existing one so it can operate at a desired level of cavitation.

  14. Valve for controlling solids flow

    International Nuclear Information System (INIS)

    A fluidized solids control valve is disclosed that is particularly well adapted for use with a flow of coal or char that includes both large particles and fines. The particles may or may not be fluidized at various times during the operation. The valve includes a tubular body that terminates in a valve seat covered by a normally closed closure plate. The valve body at the seat and the closure plate is provided with aligned longitudinal slots that receive a pivotally supported key plate. The key plate is positionable by an operator in inserted, intermediate and retracted positions respecting the longitudinal slot in the valve body. The key plate normally closes the slot within the closure plate but is shaped and aligned obliquely to the longitudinal slot within the valve body to provide progressively increasing slot openings between the inserted and retracted positions. Transfer members are provided between the operator, key plate and closure plate to move the closure plate into an open position only when the key plate is retracted from the longitudinal slot within the valve body

  15. Cavitation guide for control valves

    International Nuclear Information System (INIS)

    This guide teaches the basic fundamentals of cavitation to provide the reader with an understanding of what causes cavitation, when it occurs, and the potential problems cavitation can cause to a valve and piping system. The document provides guidelines for understanding how to reduce the cavitation and/or select control valves for a cavitating system. The guide provides a method for predicting the cavitation intensity of control valves, and how the effect of cavitation on a system will vary with valve type, valve function, valve size, operating pressure, duration of operation and details of the piping installation. The guide defines six cavitation limits identifying cavitation intensities ranging from inception to the maximum intensity possible. The intensity of the cavitation at each limit Is described, including a brief discussion of how each level of cavitation influences the valve and system. Examples are included to demonstrate how to apply the method, including making both size and pressure scale effects corrections. Methods of controlling cavitation are discussed providing information on various techniques which can be used to design a new system or modify an existing one so it can operate at a desired level of cavitation

  16. Awareness, knowledge, and practice: A survey of glaucoma in north Indian rural residents

    Directory of Open Access Journals (Sweden)

    Parveen Rewri

    2014-01-01

    Full Text Available Background: Studies done on the prevalence of glaucoma have reported a high proportion of undiagnosed patients. Late diagnosis is related to increased risk of glaucoma associated with visual disability. Lack of awareness and non-availability of appropriate screening procedures are among the major reasons for non-diagnosis or late diagnosis of glaucoma. The present study has been undertaken to evaluate the level of awareness about glaucoma among the North Indian rural population. Materials and Methods: A group-administered, questionnaire-based survey, involving 5000 rural residents (aged 20 and above was conducted through random sampling. The questionnaire was structured to evaluate the level of awareness and knowledge about glaucoma and the effect of gender, education status, and glaucoma diagnosis was also studied. The source of awareness about glaucoma was also questioned. Results: Of the 5000 individuals enrolled for the survey, responses from 4927 (98.5%; 95% Confidence Interval (CI: 98.2 - 98.9 participants, including 3104 males (63%; 95% CI: 61.7 - 64.3 and 1823 females (37%; 95% CI: 35.7 - 38.3 were evaluated. A total of 409 (~8.3%; 95% CI: 7.6 - 9.14 respondents were aware about glaucoma and only 93 (1.89%; 95% CI: 1.55 - 2.31 were qualified as having knowledge about glaucoma as per the set questionnaire. Education was the only variable significantly correlated (P value < 0.001 with the awareness and knowledge of glaucoma out of the parameters included in this study. Close acquaintance with a glaucoma patient was the most common source of information. Conclusions: There is a lack of awareness about glaucoma among the rural residents of North India. The study findings stress the need to spread awareness about glaucoma for prevention of glaucoma-related blindness.

  17. Successful thrombolysis for prosthetic pulmonary valve obstruction.

    OpenAIRE

    Lopez, J. A.; Strickman, N E; Jin, B S; X. G. Li; Phan, B; Zeluff, B J; Wilansky, S

    1995-01-01

    Thrombosis is a serious complication of prosthetic heart valve operations. In recent years, systemic thrombolysis has emerged as a suitable alternative to surgery. Experience with thrombosis of pulmonary prosthetic valves is very limited. We report a case of successful administration of intravenous streptokinase for thrombosis of a St. Jude Medical prosthetic valve 3 weeks after pulmonary valve replacement.

  18. Thermostatic Radiator Valve Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Dentz, J. [Advanced Residential Integrated Energy Solutions Collaborative (ARIES), New York, NY (United States); Ansanelli, E. [Advanced Residential Integrated Energy Solutions Collaborative (ARIES), New York, NY (United States)

    2015-01-01

    A large stock of multifamily buildings in the Northeast and Midwest are heated by steam distribution systems. Losses from these systems are typically high and a significant number of apartments are overheated much of the time. Thermostatically controlled radiator valves (TRVs) are one potential strategy to combat this problem, but have not been widely accepted by the residential retrofit market. In this project, the ARIES team sought to better understand the current usage of TRVs by key market players in steam and hot water heating and to conduct limited experiments on the effectiveness of new and old TRVs as a means of controlling space temperatures and reducing heating fuel consumption. The project included a survey of industry professionals, a field experiment comparing old and new TRVs, and cost-benefit modeling analysis using BEopt™ (Building Energy Optimization software).

  19. Ferroelectric Fluid Flow Control Valve

    Science.gov (United States)

    Jalink, Antony, Jr. (Inventor); Hellbaum, Richard F. (Inventor); Rohrbach, Wayne W. (Inventor)

    1999-01-01

    An active valve is controlled and driven by external electrical actuation of a ferroelectric actuator to provide for improved passage of the fluid during certain time periods and to provide positive closure of the valve during other time periods. The valve provides improved passage in the direction of flow and positive closure in the direction against the flow. The actuator is a dome shaped internally prestressed ferroelectric actuator having a curvature, said dome shaped actuator having a rim and an apex. and a dome height measured from a plane through said rim said apex that varies with an electric voltage applied between an inside and an outside surface of said dome shaped actuator.

  20. Valve monitoring and evaluation method

    International Nuclear Information System (INIS)

    With the valve monitoring and evaluation method presented here tools are available to optimise the operation of power plants furthermore. With ADAM a self-contained service conception for condition oriented maintenance of valves and actuators is at the operator's disposal. It includes efficient test and diagnosis systems for online and offline use as well as the affiliated engineering procedures and the contribution to the condition evaluating process. Gathered knowledge about the functional behaviour of valves and actuators in detail leads to remarkably increased safety and availability combined with a lucrative reduction of maintenance efforts. (Author)

  1. Valve leakage inspection testing and maintenance process

    International Nuclear Information System (INIS)

    In valve maintenance, packing rings that prevent leakage along the valve stem must periodically be replaced, either during routine maintenance or to correct a leak or valve malfunction. Tools and procedures currently in use for valve packing removal and inspection are generally of limited value due to various access and application problems. A process has been developed by AECL Research that addresses these problems. The process, using incompressible fluid pressure, quickly and efficiently confirms the integrity of the valve backseat, extracts hard-to-remove valve packing sets, and verifies the leak tightness of the repacked valve

  2. [Cyclocryocoagulation in treatment of neovascular glaucoma].

    Science.gov (United States)

    Kovacić, Zeljko; Ivanisević, Milan; Rogosić, Veljko; Plavec, Andrea; Karelović, Deni

    2004-01-01

    Neovascular glaucoma (NVG) is a pathological condition of the eye with fast deterioration, accompanied with eyeball pain and loosing sight. The aim of the study was to examine the efficacy of cryotherapy in the treatment of NVG which is resistant to medical and surgical therapy, concerning intraocular pressure (IOT) and eyeball pain immediately after the treatment and 6 months after. In the Department of Ophthalmology, Split University Scool of Medicine, during three years 70 patients with NVG, which were resistant to medical and surgical treatment, were included in the prospective study. There were 50 males and 21 women, average age 74 +/- 6.94 (45-87). The patients were treated with transconjuctival cyclocryocoagulation, machine ERBOKRYIO AE-ERBE was used. The average value of IOT was: at admission 44.8 mmHg, 7 days after the treatment 30.7 mmHg with the tendency of falling down 30 and 90 days later, to finally 19.9 mmHg 180 days after the treatment. The IOT was significantly lower after the treatment. At admission, the average value of eyeball pain intensity was high (4.2), 7 days after the treatment it was 2.1 with the tendency of falling down to finally 1.1 180 days after the treatment. The eyeball pain intensity was significantly lower after the treatment. Cyclocryocoagulation is a method of choice in the treatment of NVG resistant to medical and surgical treatment. Cyclocryocoagulation, as a treatment of noncontrolled progressive NVG, does not have any effect on the improvement of sight in these patient. PMID:15918320

  3. Custo real do tratamento do glaucoma para o paciente The real cost of glaucoma treatment for an outpatient

    Directory of Open Access Journals (Sweden)

    Larissa Pedroso

    1999-12-01

    Full Text Available Objetivo: Avaliar o custo do tratamento do glaucoma para o paciente, numa instituição de ensino médico. Casuística e Métodos: Foram aplicados, aleatoriamente, questionários, na forma de entrevista ativa, a 94 pacientes do ambulatório do Setor de Glaucoma do Departamento de Oftalmologia da Universidade Federal de São Paulo, analisando gastos pessoais e com medicamentos antiglaucomatosos. Os dados foram agrupados, tabulados e foi realizada separação da amostra em dois grupos: pacientes cirúrgicos e não-cirúrgicos. Resultados: A mediana do gasto total anual estimado com glaucoma foi de R$ 480,15, o equivalente a 13% da renda anual mediana dos pacientes. Separadamente, o grupo dos pacientes cirúrgicos obteve uma mediana dos gastos totais estimados de R$ 677,94, o que corresponde a 19% da renda mediana anual. Já o grupo dos pacientes não-cirúrgicos, apresentou mediana de R$ 393,54, representando 11% da renda mediana anual. Foi encontrada diferença estatisticamente significante entre os grupos cirúrgico e não-cirúrgico para o gasto total anual (p = 0,012. Conclusão: Observou-se que o custo do tratamento na renda familiar de pessoas portadoras de glaucoma é considerável, mesmo em uma instituição públicaPurpose: To evaluate the cost of glaucoma treatment for an outpatient in a public university hospital. Patients and Methods: Ninety-four outpatients were ran-domly Glaucoma Clinic of the Ophthalmology Department of the Universidade Federal de São Paulo, submitted to questionnaires at the regarding personal and antiglaucoma medicine expenses. Data collected, tabulated and the sample was divided into two were groups: surgical and nonsurgical. Results: The median estimated total spent annually on glaucoma treatment was R$ 480.15, equivalent to 13% of the median annual family income of the patients. When the sample was divided into two groups, the figures were quite different. The surgical group had a median annual estimated total

  4. Intravitreal Bevacizumab (Avastin Injection for Neovascular Glaucoma

    Directory of Open Access Journals (Sweden)

    Shahin Yazdani

    2008-12-01

    Full Text Available

    PURPOSE: To report two cases with neovascular glaucoma secondary to ischemic central retinal vein occlusion (CRVO who were treated with intravitreal bevacizumab. CASE REPORT: Two patients were referred for neovascular glaucoma following CRVO. Visual acuity was light perception. Both eyes had extensive iris neovascularization (NVI, synechial angle closure and high intraocular pressure (IOP in spite of anti-glaucoma medications. After obtaining informed consent, both eye received an intravitreal injection of 2.5 mg (0.1 ml bevacizumab (Avastin. Both eyes demonstrated dramatic IOP reduction together with decreased severity and extent of NVI during 4 weeks of follow up. Visual acuity remained unchanged. CONCLUSION: Despite the dramatic short-term response in terms of IOP reduction and regression of neovascularization, due to limited clinical experience, one should consider this novel indication for bevacizumab cautiously.

  1. Minimally Invasive Aortic Valve Replacement

    Medline Plus

    Full Text Available ... Dr. Jim Winkley, who's a cardiac anesthesiologist that works here with us. Before we begin, viewers need ... the valve itself has narrowed, that puts more work on the heart when a patient's at rest. ...

  2. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... heart valve which is made out of pyrolitic carbon, basically metal and plastic. Again, blood flows through ... heart surgery here, we actually insufflate, or instill carbon dioxide gas into the field, which we think ...

  3. Minimally Invasive Aortic Valve Replacement

    Medline Plus

    Full Text Available ... valve is made of three pieces of thin tissue that opens freely when the heart contracts. On ... a lot of calcium and thickening of that tissue and does not open easily or appropriately. This ...

  4. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... North Carolina. My name is John Streitman and I'm a cardiothoracic surgeon here at the Heart ... the corrective surgery of aortic valve replacement. If I have aortic stenosis, are there any activities that ...

  5. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... Winkley nor myself have any financial or professional relationships with the manufacturers or the devices used in ... John, just to interrupt for moment, Charles, Charles V., asks can the mitral valve also be replaced ...

  6. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... patient's heart should have to undergo. Once again, serial evaluations, as with any chronic disease process, are ... to prevent such a problem. Is there a higher risk in someone with a biological valve for ...

  7. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... Jim. Those are coming. There are several valve companies in this country and in Europe that have ... that we've had customized by an instrument company for this approach that really works nicely for ...

  8. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... valves are an excellent option. They have great properties, from a hemodynamic perspective. Their main limitation is ... Dacron sewing ring. Dacron is a woven polyester material that's used for -- it's basically a medical grade ...

  9. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... back in World War II to look for things in the water. Basically, you use sound waves ... valve replacements a year. So one of the things I 10 would counsel anybody is before they ...

  10. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... starts out as a disease we call aortic sclerosis, which is the beginning of the process of ... path life. Again, it's a progressive disease from sclerosis, or the beginning of thickening of the valve, ...

  11. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... and then requires a cadaveric, or a deceased person's, pulmonic valve to be placed in place of ... any procedure, never be afraid to ask that person who's doing the procedure, "Have you done it ...

  12. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... surgery in our community. Aortic stenosis is a process by which the aortic valve, which is the ... and does not open easily or appropriately. This process starts out as a disease we call aortic ...

  13. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... thank you, Jim. This is obviously just a model of the heart just to give some perspective ... the aorta at this point. 9 Earlier this month Robin Williams had his aortic valve replaced and ...

  14. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... a patient less post-operative pain, blood loss, lung dysfunction. Certainly we can get these patients up ... thorocotomy is an incision we generally use for lung operations and for some valve operations in which ...

  15. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... conditions or other significant medical problems, the American College of Cardiology recommends aortic valve replacement for basically ... more likely we see aortic stenosis. Again, patient education is part of the evaluation and management of ...

  16. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... when it progresses to stenosis, by either an increase in velocity of blood through the valve or ... in a normal patient, exercise and increased activity increases your heart rate and blood pressure, which then ...

  17. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... algorithms we employ. After we do a detailed history and physical examination, we generally recommend in most ... thinner, or cumadin, anticoagulation to be taken for life. So the tradeoff again is tissue valves not ...

  18. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... that neither Dr. Winkley nor myself have any financial or professional relationships with the manufacturers or the ... a rare problem where the patient's own immune system will attack cardiac valve structures, causing them to ...

  19. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... to prevent such a problem. Is there a higher risk in someone with a biological valve for ... there but in my experience they're no higher than in someone who's had a full sternotomy. ...

  20. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... able to look at the aortic valve very well. In fact, transesophageal echocardiography is the best modality ... use to help evaluate both cardiac function as well as anatomy in patients who need heart surgery. ...

  1. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... see aortic stenosis in patients younger, in their 40s and 50s, if they have congenitally bicuspid, or ... a year and, you know, probably 30 to 40 minimally invasive aortic valve replacements a year. So ...

  2. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... as represented by the red and the blue color. Typically, blood flowing through a valve should be ... and smooth. We shouldn't see very much color such as we're seeing here. To the ...

  3. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... Hospital in Pinehurst, North Carolina. During the program, it's easy for you to learn about the procedure. ... the aortic valve, and proceeds to aortic stenosis. It's really not felt to be due to wear ...

  4. Minimally Invasive Aortic Valve Replacement

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    Full Text Available ... surgery. I think as physicians we owe a responsibility to our patients to try to make procedures ... patients back annually, which we feel is our responsibility any time we do valve replacement or repair ...

  5. Statistical and neural net methods for automatic glaucoma diagnosis determination

    Czech Academy of Sciences Publication Activity Database

    Pluháček, F.; Pospíšil, Jaroslav

    2004-01-01

    Roč. 1, č. 2 (2004), s. 12-24. ISSN 1644-3608 Institutional research plan: CEZ:AV0Z1010921 Keywords : glaucoma * diagnostic methods * pallor * image analysis * statistical evaluation Subject RIV: BH - Optics, Masers, Lasers Impact factor: 0.375, year: 2004

  6. [Historical notes on the terms "glaucoma" and "cataract" (author's transl)].

    Science.gov (United States)

    Rintelen, F

    1977-02-01

    The Greek term "glaucoma" has nothing to do with the disease we call glaucoma today and that we use to translate incorrectly with "grüner Star" throughout the German-speaking countries. The Greek adjective "glaucos" does not mean green but gleaming, sparkling. It signified the discolouring of the pupil in glaucoma. It was later replaced by the pathogenetic term hypochysis, Latin suffusio, denoting the supposed "trübe Feuchte" (opaque humour) that was taught to gather and congeal in front of the crystalline lens. Later on "glaukosis" was reserved for incurable cases, disease of the crystalline lens itself, which was looked at as the "organon visus" up to Felix Plater. The word "cataract"--waterfall--does not exist in Greek medicine. It appears in Salernitan medical science around the year 1000 as a synonym for hypochysis, the disease we call cataract today and which has been identified as opacity of the lens since Brisseau (1705). The nature of "incurable" glaucoma, later considered as a disease of the vitreous body, was clearly recognized as a consequence of intraocular increase of pressure only by v. Graefe. PMID:323562

  7. Systemic antihypertensive medication and incident open-angle glaucoma

    NARCIS (Netherlands)

    Muskens, Rogier P. H. M.; de Voogd, Simone; Wolfs, Roger C. W.; Witteman, Jacqueline C. M.; Hofman, Albert; de Jong, Paulus T. V. M.; Stricker, Bruno H. C.; Jansonius, Nomdo M.

    2007-01-01

    Purpose: To determine the association between systemic anti hypertensive medication and incident open-angle glaucoma. Design: Prospective population-based cohort study. Participants: The study population consisted of a subset of 3842 participants of the Rotterdam Study for whom data from identical o

  8. Current concepts in the diagnosis and management of developmental glaucomas

    Directory of Open Access Journals (Sweden)

    Mandal Anil

    1993-01-01

    Full Text Available Developmental glaucoma is a global problem and has a broad range of ocular manifestations and is sometimes associated with systemic disorders and syndromes. It poses a major diagnostic and management problem to the ophthalmologists. A proper diagnostic evaluation under general anesthesia is advisable for all children who do not cooperate for an office examination. Surgery remains the principal therapeutic modality in the management of developmental glaucoma and medical therapy is limited to a supplemental role while the child is being prepared for surgery. Conventional angle incision surgery (goniotomy and trabeculotomy ab externo is uniquely valuable in the management of primary developmental glaucoma, while combined trabeculotomy cum trabeculectomy offers the best hope of success in advanced cases. In recent years, artificial drainage devices such as the Molteno implant seem to be promising for safe and effective pressure control in children with refractory developmental glaucoma. Visual rehabilitation involves correction of refractive errors, removal of opacities in media (i.e. cataract or corneal scarring and aggressive amblyopia therapy. Early diagnosis, prompt institution of therapy combined with commitment from the family for postoperative follow-up care are critical for the restoration of good visual function.

  9. Minimally invasive glaucoma surgery: current status and future prospects

    Directory of Open Access Journals (Sweden)

    Richter GM

    2016-01-01

    Full Text Available Grace M Richter,1,2 Anne L Coleman11UCLA Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, CA, USA; 2USC Eye Institute, Department of Ophthalmology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USAAbstract: Minimally invasive glaucoma surgery aims to provide a medication-sparing, conjunctival-sparing, ab interno approach to intraocular pressure reduction for patients with mild-to-moderate glaucoma that is safer than traditional incisional glaucoma surgery. The current approaches include: increasing trabecular outflow (Trabectome, iStent, Hydrus stent, gonioscopy-assisted transluminal trabeculotomy, excimer laser trabeculotomy; suprachoroidal shunts (Cypass micro-stent; reducing aqueous production (endocyclophotocoagulation; and subconjunctival filtration (XEN gel stent. The data on each surgical procedure for each of these approaches are reviewed in this article, patient selection pearls learned to date are discussed, and expectations for the future are examined. Keywords: MIGS, microincisional glaucoma surgery, trabecular stent, Schlemm’s canal, suprachoroidal shunt, ab interno

  10. Difficulty with Out-Loud and Silent Reading in Glaucoma

    OpenAIRE

    Ramulu, Pradeep Y.; Swenor, Bonnielin K.; Jefferys, Joan L.; Friedman, David S.; Rubin, Gary S.

    2013-01-01

    Bilateral visual field loss from glaucoma is associated with slower reading speed and decline of reading speed during prolonged silent reading. Silent reading speed over prolonged durations is more affected by glaucomatous visual field loss than reading out loud for short durations.

  11. Aerobic exercise and intraocular pressure in normotensive and glaucoma patients

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    Chatzibalis Theodosios

    2009-08-01

    Full Text Available Abstract Background With the increasing number of people participating in physical aerobic exercise, jogging in particular, we considered that it would be worth knowing if there are should be limits to the exercise with regard to the intraocular pressure (IOP of the eyes. The purpose of this study is to check IOP in healthy and primary glaucoma patients after aerobic exercise. Methods 145 individuals were subdivided into seven groups: normotensives who exercised regularly (Group A; normotensives in whose right eye (RE timolol maleate 0.5% (Group B, latanoprost 0.005% (Group C, or brimonidine tartrate 0.2% (Group D was instilled; and primary glaucoma patients under monotherapy with β-blockers (Group E, prostaglandin analogues (Group F or combined antiglaucoma treatment (Group G instilled in both eyes. The IOP of both eyes was measured before and after exercise. Results A statistically significant decrease was found in IOP during jogging. The aerobic exercise reduces the IOP in those eyes where a b-blocker, a prostaglandin analogue or an α-agonist was previously instilled. The IOP is also decreased in glaucoma patients who are already under antiglaucoma treatment. Conclusion There is no ocular restriction for simple glaucoma patients in performing aerobic physical activity.

  12. THE POET MINDING THE LOCAL INSTRUMENTS: AHMED-I DÂI (THE PROVERBS AND IDIOMS YEREL MALZEMEYİ ÖNEMSEYEN BİR ŞAİR: AHMED-İ DÂİ (DİVANINDA KULLANDIĞI ATASÖZLERİ VE DEYİMLER

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    M. Ziya BAĞRIAÇIK

    2009-08-01

    Full Text Available Discussion about the language and style of classic (Divan poem has always been one of the major discussion in literature. While the poets of XIV and XV centuries have kept significant distance with the meaning by focusing on the local matters, their successors have profoundly focused on the poems that attempt to explore the meaning further. However, the latter poems have been criticized for gradual engagement in exhibition of their ingenuities. On the contrary to the establishing era, in Gibb’s expression, “the İranization was more prominent”at XVI, XVII, and XVIII centuries. Although there were some efforts against this resignation in terms of localization during the following centuries, these have not been successful so far. Because, the indigenous attitudes of poets in exspressing their poems in Turkish at early stage have nearly been replaced by the artificial efforts right after the localization. This indigenous style initiated by Yunus and Sultan Veled at earlier era has been followed by Asik Pasa, Gulsehrî, Ahmedî and Kadı Burhaneddin. Right at the beginning of the XV century, Ahmed-i Daî has taken over the mission and turned it over to Necati. This article deals with Ahmed-i Dai’s efforts. Klasik (divan şiirin dil ve üslubu günümüze değin hep tartışılagelmiştir. Teşekkül (XIV-XV aşamasındaki şairler yerel malzemeye sarılıp satıhta dolaşmışlar; halefleri ise manayı daha derinleştirme gayretiyle aşkın şiirler söyleyerek, işi zamanla bir hüner gösterme yarışına dönüştürdükleri için eleştirilmişlerdir. Kuruluş döneminin aksine XVI-XVII-XVIII yüzyıllar Gibb’in deyimiyle Îranîleşmenin daha belirgin olduğu bir dönemdir. Her ne kadar daha sonraki yüzyıllarda bu teslimiyete mahallîleşme adında bir tepki çabası gösterilse de çok başarılı olduğu söylenemez. Zira ilk başlardaki şairlerin Türkçe söyleme konusundaki takındıkları tabiî tavır mahall

  13. Brucella Endocarditis in Prosthetic Valves

    OpenAIRE

    Mehanic, Snjezana; Mulabdic, Velida; Baljic, Rusmir; Hadzovic-Cengic, Meliha; Pinjo, Fikret; Hadziosmanovic, Vesna; Topalovic, Jasna

    2012-01-01

    SUMMARY CONFLICT OF INTEREST: none declared. Introduction Brucella endocarditis (BE) is a rare but severe and potentially lethal manifestation of brucellosis. Pre-existing valves lesions and prosthetic valves (PV) are favorable for BE. Case report We represent the case of a 46-year-old man who was treated at the Clinic for Infectious Diseases, Clinical Center of Sarajevo University, as blood culture positive (Brucella melitensis) mitral and aortic PV endocarditis. He was treated with combined...

  14. Tissue-engineered heart valves

    Czech Academy of Sciences Publication Activity Database

    Filová, Elena; Straka, František; Miřejovský, T.; Mašín, J.; Bačáková, Lucie

    2009-01-01

    Roč. 58, Suppl.2 (2009), S141-S158. ISSN 0862-8408 R&D Projects: GA MŠk(CZ) 1M0510; GA AV ČR(CZ) 1QS500110564 Institutional research plan: CEZ:AV0Z50110509 Keywords : bioarteficial heart valve * valve interstitial cells * pulse flow bioreactor Subject RIV: EI - Biotechnology ; Bionics Impact factor: 1.430, year: 2009

  15. Economic burden of glaucoma in Rivers State, Nigeria

    Directory of Open Access Journals (Sweden)

    Adio AO

    2012-12-01

    Full Text Available Adedayo O Adio,1 Alfred A Onua21University Of Port Harcourt Teaching Hospital, 2Braithwaite Memorial Specialist Hospital, Port Harcourt, Rivers State, NigeriaBackground: Primary open angle glaucoma is reported to blind 150,000 people in the Nigerian population and over 7000 in Rivers State, and requires constant follow-up. Compliance is a challenge, given that most inhabitants live below the poverty line. This study was performed to determine how Nigerian patients are affected economically by the disease.Methods: Consecutive adult patients attending the eye clinic of the University of Port Harcourt Teaching Hospital, Rivers State, Nigeria, with a diagnosis of primary open angle glaucoma and on outpatient antiglaucoma treatment in the first 6 months of 2006, were recruited for the study. The lowest paid government worker was on USD50 (N7500.00 per month and the gross domestic product per capita was USD1150 for the period under review.Results: We enrolled 120 consecutive patients of mean age 52.7 ± 10.4 years, with a male to female ratio of 2:3. The most common occupations were in the civil service (n = 56, 46.7%. All participants were on topical antiglaucoma treatment. The average cost of medical antiglaucoma medication was N6000 (USD40 per month. Computed to include indirect costs, including medical laboratory tests, transportation, and care by patient escorts, an average sum of USD105.4 (N15,810 was spent by each patient per month. Most of the patients (73.3% were responsible for their own treatment costs. No patient accepted the cheaper option of surgery (USD275.4, N41,310. Eighty of the patients (66.7% visited our eye clinic monthly. Direct and indirect loss to the economy was USD3,064587 per annum from those already blind. This was in addition to the USD 4.1 million being spent yearly on medical treatment by those who were visually impaired by glaucoma.Conclusion: Middle-income earners spent over 50% of their monthly income and low

  16. Diagnostic Accuracy of Nonmydriatic Fundus Photography for the Detection of Glaucoma in Diabetic Patients

    Science.gov (United States)

    Muñoz-Negrete, Francisco J.; Contreras, Inés; Oblanca, Noelia; Pinazo-Durán, M. Dolores; Rebolleda, Gema

    2015-01-01

    Purpose. To determine the diagnostic accuracy for glaucoma of a set of criteria with nonmydriatic monoscopic fundus photography (NMFP) in diabetics. Methods. Diabetics recruited from a screening program for diabetic retinopathy and diabetic glaucoma patients recruited from our glaucoma unit were included. Any patient with evidence of diabetic retinopathy was excluded. Diabetic patients had to have no visual field defects to be included as controls. Glaucoma patients had to have a glaucomatous field defect in at least one eye to be included. One NMFP was taken per eye for all subjects. These photographs were evaluated by two masked glaucoma specialists for the presence of the following: bilateral cup to disc (C/D) ratio ≥0.6, notching or thinning of the neuroretinal rim, disc hemorrhages, and asymmetry in the C/D ratio between both eyes ≥0.2. This evaluation led to a dichotomous classification: if any of the above criteria was present, the patient was classified as glaucoma. If none were present, the patient was classified as normal. Results. 72 control subjects and 72 glaucoma patients were included. Evaluation of NMFP had a sensitivity of 79.17% and a specificity of 80.56% for specialist 1 and a sensitivity of 72.22% and a specificity of 88.88% for specialist 2 for the detection of glaucoma. The overall accuracy was 79.83% and 80.55%, respectively. Discussion. NMFP evaluation by a glaucoma specialist may be useful for the detection of glaucoma in diabetics. PMID:26557709

  17. Epidemiology of glaucoma in Sub-Saharan Africa: Prevalence, incidence and risk factors

    Directory of Open Access Journals (Sweden)

    Fatima Kyari

    2013-01-01

    Methods: Electronic databases (PubMed, MedLine, African Journals Online- AJOL were searched using the full text, Medical Subject Headings (MeSH terms, author(s and title to identify publications since 1982 in the following areas: population-based glaucoma prevalence and incidence studies in SSA and in African-derived black populations outside Africa; population-based prevalence and incidence of blindness and visual impairment studies in SSA including rapid assessment methods, which elucidate the glaucoma-specific blindness prevalence; studies of risk factors for glaucoma; and publications that discussed public health approaches for the control of glaucoma in Africa. Results: Studies highlighted that glaucoma in SSA is a public health problem and predominantly open-angle glaucoma. It is the second-leading cause of blindness, has a high prevalence, an early onset and progresses more rapidly than in Caucasians. These factors are further compounded by poor awareness and low knowledge about glaucoma even by persons affected by the condition. Conclusion: Glaucoma care needs to be given high priority in Vision 2020 programs in Africa. Many questions remain unanswered and there is a need for further research in glaucoma in SSA in all aspects especially epidemiology and clinical care and outcomes involving randomized controlled trials. Genetic and genome-wide association studies may aid identification of high-risk groups. Social sciences and qualitative studies, health economics and health systems research will also enhance public health approaches for the prevention of blindness due to glaucoma.

  18. The love moaning of a poet: the vocabulary of the letters written by Ahmed Arif to Leyla ErbilBir şairin aşk iniltileri: Ahmed Arif’ten Leyla Erbil’e mektupların söz varlığı

    Directory of Open Access Journals (Sweden)

    Sami Baskın

    2015-09-01

    Full Text Available Ahmed Arif, who is one of the Sociable Poets of the 1940s, wrote about the topics in his works in a romantic style. The enthusiasm and the romance in his works separates him from other poets of the era. Although he wrote only one poetry book, his poems such as Hasretinden Prangalar Eskittim, Haberin Var mı? (İçerde, Terketmedi Sevdan Beni became famous and were composed and sung by famous singers of Turkey like Funda Arar, Ahmet Kaya, Suavi, Edip Akbayram, Cem Karaca. These events made him become a famous poet not only in a narrow society who had similar thoughts, but also all over Turkey. There are many sources for the lyricism and romance that gave him this fame. However, the most important share among these many sources belongs to his love for Leyla Erbil. He did not limit his love with poems and he conveyed his love for Leyla Erbil in the letters he wrote, most of which were written between the years 1954-1959, and the last of which was written in 1977. In his poems, Ahmed Arif told his love, his environment, the intellectual world of the era, his exiles and the challenges he had experienced. All these reasons make the verbal existence of the Letters from Ahmed Arif to Leyla Erbil important. For this reason, in this study, the letters are examined in terms of verbal existence and the words in his works are classified under titles such as Basic Word Existence, Proverbs, Phrases, Terms, Verbal Structures, Reduplications, Slang and Expletives, Sayings specific to Diyarbakır, etc. and the concept areas are defined. As a result of this, it has been determined that Ahmed Arif was infatuated with Leyla Erbil, he even placed her in the very center of his personal life, sometimes he deified her, and defined her as “My lady, my friend, by sister, my daughter, my god, my messenger”. Moreover, it was also observed that the local sayings, phrases, and especially slang and expletives have important places in Ahmed Arif’s vocabulary.  

  19. A Rare Manifestation of Uveitis-glaucoma-hyphema Syndrome

    Science.gov (United States)

    Leal, Inês; Faria, Mun Yueh; Pinto, Luís Abegão

    2016-01-01

    ABSTRACT Aims: To report a case of a patient who developed uveitis-glaucoma-hyphema (UGH) syndrome after an uneventful cataract surgery and to discuss risk factors, diagnostic challenges, management options, and clinical implications. Background: Uveitis-glaucoma-hyphema syndrome is a rare but potentially serious cataract surgery complication. Clinical manifestations include increased intraocular pressure (IOP), anterior chamber inflammation, and recurrent hyphema or microhyphema. Uveitis-glaucoma-hyphema Plus syndrome also includes accompanying vitreous hemorrhage. Although classically associated with rigid anterior chamber intraocular lenses (lOLs), cases of malpositioning and subluxated posterior chamber lOLs have also been described as possible triggers. Case description: We report a case of a 70-year-old Caucasian man who developed UGH Plus syndrome after an uneventful cataract surgery with an lOL implanted in the capsular bag. During postoperative follow-up, persistent intraocular inflammation, increased IOP, hyphema, and vitreous hemorrhage were consistent with this diagnosis. Slit-lamp examination demonstrated progressive localized iris atrophy, compatible with chafing of the posterior iris by the IOL haptic as the trigger for UGH syndrome. A pars plana vitrectomy was performed and a retropupillary intraocular lens was implanted. No further complications occurred during follow-up. Conclusion and clinical significance: Given the increasing prevalence of single-piece lOLs implanted in the capsular bag, it is important to recognize UGH syndrome as a rare but potentially serious complication. How to cite this article: Sousa DC, Leal I, Faria MY, Pinto LA. A Rare Manifestation of Uveitis-glaucoma-hyphema Syndrome. J Curr Glaucoma Pract 2016;10(2):76-78. PMID:27536051

  20. Comparative study between trabeculectomy with photodynamic therapy (BCECF-AM and trabeculectomy with antimetabolite (MMC in the treatment of primary open angle glaucoma

    Directory of Open Access Journals (Sweden)

    Saeed AM

    2012-10-01

    Full Text Available Ahmed M SaeedOphthalmology Department, Benha University, Benha, EgyptBackground: Various methods have been investigated to avoid postoperative scarring of the filtering bleb in modern glaucoma surgery. Most deal with the application of antimetabolic drugs such as mitomycin C (MMC. 2’,7’-bis-(2-carboxyethyl-5-(and-6-carboxyfluorescein, acetoxymethyl ester (BCECF-AM is a locally acting intracellular photosensitizer which could control and decrease postoperative fibrosis at the trabeculectomy site.Purpose: To compare the effect of photodynamic therapy in combination with trabeculectomy to the effect of MMC combined with the same procedure in controlling postoperative intraocular pressure (IOP in patients with medically uncontrolled primary open angle glaucoma (1ry OAG.Methods: A randomized controlled clinical trial was conducted on 76 eyes of 76 patients divided into three groups undergoing trabeculectomy, trabeculectomy with BCECF-AM (group A, trabeculectomy with MMC (group B, and trabeculectomy only as a control group (group C. Patients were reviewed postoperatively for clinical evaluation and photo documentation of the blebs with a fundus camera and ultrasonic biomicroscopy (UBM. The desirable effect of the adjunctive material was evaluated according to the clinical efficacy, tolerability, and safety by comparison with the control group.Setting: Benha University Hospital, Benha, Egypt.Results: After a mean follow-up of 24 months, all procedures succeeded in lowering IOP. The cumulative probability of complete success at the 24 month follow-up was 91% for group B, compared to 82% and 81.5% for group A and group C, respectively. The percentage of complete success was highest for group B, second highest for group A, and lowest for group C over the follow-up period; however, these differences were not statistically significant (P > 0.05. Regarding the bleb morphology and UBM reflectivity, the differences were not statistically significant (P > 0