Sample records for ahb compatible ddr

  1. Ahb Compatible DDR Sdram Controller Ip Core for Arm Based Soc

    CERN Document Server

    Shashikumar, Dr R; Nagendrakumar, M; Hemanthkumar, C S


    DDR SDRAM is similar in function to the regular SDRAM but doubles the bandwidth of the memory by transferring data on both edges of the clock cycles. DDR SDRAM most commonly used in various embedded application like networking, image or video processing, Laptops ete. Now a days many applications needs more and more cheap and fast memory. Especially in the field of signal processing, requires significant amount of memory. The most used type of dynamic memory for that purpose is DDR SDRAM. For FPGA design the IC manufacturers are providing commercial memory controller IP cores working only on their products. Main disadvantage is the lack of memory access optimization for random memory access patterns. The data path part of those controllers can be used free of charge. This work propose an architecture of a DDR SDRAM controller, which takes advantage of those available and well tested data paths and can be used for any FPGA device or ASIC design.(5). In most of the SOC design, DDR SDRAM is commonly used. ARM pro...

  2. Parameterized Synthesis Case Study: AMBA AHB

    Directory of Open Access Journals (Sweden)

    Roderick Bloem


    Full Text Available We revisit the AMBA AHB case study that has been used as a benchmark for several reactive synthesis tools. Synthesizing AMBA AHB implementations that can serve a large number of masters is still a difficult problem. We demonstrate how to use parameterized synthesis in token rings to obtain an implementation for a component that serves a single master, and can be arranged in a ring of arbitrarily many components. We describe new tricks - property decompositional synthesis, and direct encoding of simple GR(1 - that together with previously described optimizations allowed us to synthesize a component model with 14 states in about 1 hour.

  3. Multi Resolution AHB Bus Tracer with Real Time Compression for SOC

    Directory of Open Access Journals (Sweden)

    J. Jagadish Reddy


    Full Text Available AMBA (Advanced Microcontroller based Bus Architecture consists of AHB, APB, ASB and AXI. In this project we are Tracing AHB (Advanced High performance Bus signals with Real time Compression and Multi-resolution Techniques. A simple transaction on the AHB consists of an address phase and a subsequent data phase. Access to the target device is controlled through a MUX , thereby admitting bus-access to one bus-master at a time. In AHB Tracer we have to Trace Address signals, Data signals and Control signals, we have to compress them depending on AHB protocols. A multi-resolution AHB on-chip bus tracer is named as SYS_HMRBT (AHB Multi-resolution Bus Tracer and is used for monitoring. The goal is to provide better compression quality and multiple resolution traces to meet the complex SoC debugging needs. Compressing all signals at cycle-accurate-level does not always meet the debugging needs. As SOCs become more complex, the transaction level debugging becomes increasingly important, since it helps designers focus on the functional behaviors, instead of interpreting complex signals. By using this SYS_HMRBT, we can achieve 79%-96% of compression depending on selected resolution mode. Tools Used for this Project are Modelsim for Simulation, and Xilinx ISE II for Synthesis

  4. Adaptive Hysteresis Band Current Control (AHB) with PLL of Grid Side Converter-Based Wind Power Generation System

    DEFF Research Database (Denmark)

    Guo, Yougui; Zeng, Ping; Li, Lijuan


    Adaptive hysteresis band current control(AHB CC) is used to control the three-phase grid currents by means of grid side converter in wind power generation system in this paper. AHB has reached the good purpose with PLL (Lock phase loop). First the mathematical models of each part are given...

  5. 并符合DDR1/DDR2/DDR3标准要求

    Institute of Scientific and Technical Information of China (English)


    加利福尼亚州米尔皮塔斯(MILPITAS,CA)凌力尔特公司(Linear Technology Corporation)推出高效率双输出同步降压型DC/DC控制器LTC3876,该器件为DDR1/DDR2/DDR3以及未来的标准存储器应用产生VDDQ电源电压、VTT总线终端电压和VTTR基准电压。第一个通道的输出产生VDDQ,并可在电流高达25 A时,在2.5~1 V的范围内设定VDDQ。

  6. DDR-Umweltschutz zum Nachschlagen

    DEFF Research Database (Denmark)

    Czeskleba-Dupont, Rolf


    Anmeldelsen af denne dokumentation af legale og politiske rammebetingelsere (bind 1), mediale og sektorale beskrivelser (bind 2) samt af forskellige organisationsformer for miljøbeskuttelsesarbejde i DDR fremhæver ngole strategiske og teoretiske problemer, som bidragene rejser. Vægten er lagt på de...

  7. iImplementation of AMBA AHB protocol for high capacity memory management using VHDL

    Directory of Open Access Journals (Sweden)

    Varsha vishwarkama


    Full Text Available Microprocessor performance has improved rapidly these years. In contrast memory latencies and bandwidths have improved little. The result is that the memory access time is the bottleneck which limits the system performance. In case of larger system design which requires more number of I/O ports and more memory capacity the system designer may interface external I/O ports and memory with the system. In this paper we are using advanced microcontroller bus architecture with its advanced high performance bus. AMBA AHB provides parallel communications with multi master bus management, high clock frequency, high performance systems for data transfer operation from the memory interfaced with the master or slave peripheral devices. AMBA AHB supports on chip communications standard for designing high-performance embedded microcontrollers.

  8. DDR FCRAM改进DDR SDRAM设计性能%DDR FCRAM Boosts Performance in DDR SDRAM Designs

    Institute of Scientific and Technical Information of China (English)


    @@ 同步DRAM技术的改型产品-双数据数率快周期环随机存取存储器(DDR FCRAM)本主要集中用于网络市场领域.但由于其性能高,还适合用于诸如图形、游戏和高端机顶盒等应用领域.

  9. Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer. (United States)

    Terai, Hideki; Tan, Li; Beauchamp, Ellen M; Hatcher, John M; Liu, Qingsong; Meyerson, Matthew; Gray, Nathanael S; Hammerman, Peter S


    Despite advances in precision medicine approaches over the past decade, the majority of nonsmall cell lung cancers (NSCLCs) are refractory to treatment with targeted small molecule inhibitors. Previous work has identified mutations in the Discoidin Domain Receptor 2 (DDR2) kinase as potential therapeutic targets in NSCLCs. While DDR2 is potently targeted by several multitargeted kinase inhibitors, most notably dasatinib, toxicity has limited the clinical application of anti-DDR2 therapy. Here, we have characterized compound 1 and other tool compounds demonstrating selectivity for DDR2 and show that while these compounds inhibit DDR2 in lung cancer model systems, they display limited antiproliferative activity in DDR2 mutated cell lines as compared to dual DDR2/SRC inhibitors. We show that DDR2 and SRC are binding partners, that SRC activity is tied to DDR2 activation, and that dual inhibition of both DDR2 and SRC leads to enhanced suppression of DDR2 mutated lung cancer cell lines. These results support the further evaluation of dual SRC/DDR2 targeting in NSCLC, and we report a tool compound, compound 5, which potently inhibits both SRC and DDR2 with a distinct selectivity profile as compared to dasatinib.

  10. Radiation hard Monolithic SDRAM to support DDR2 and DDR3 architectures Project (United States)

    National Aeronautics and Space Administration — There is no rad hard SDRAM currently available to support DDR2 and DDR3 applications. Space Micro proposes to build a radiation hardened by design (RHBD) SDRAM...

  11. COP9 signalosome function in the DDR. (United States)

    Hannss, Ronny; Dubiel, Wolfgang


    The COP9 signalosome (CSN) is a platform for protein communication in eukaryotic cells. It has an intrinsic metalloprotease that removes the ubiquitin (Ub)-like protein Nedd8 from cullins. CSN-mediated deneddylation regulates culling-RING Ub ligases (CRLs) and controls ubiquitination of proteins involved in DNA damage response (DDR). CSN forms complexes with CRLs containing cullin 4 (CRL4s) which act on chromatin playing crucial roles in DNA repair, checkpoint control and chromatin remodeling. Furthermore, via associated kinases the CSN controls the stability of DDR effectors such as p53 and p27 and thereby the DDR outcome. DDR is a protection against cancer and deregulation of CSN function causes cancer making it an attractive pharmacological target. Here we review current knowledge on CSN function in DDR.

  12. NEPP DDR Device Reliability FY13 Report (United States)

    Guertin, Steven M.; Armbar, Mehran


    This document reports the status of the NEPP Double Data Rate (DDR) Device Reliability effort for FY2013. The task targeted general reliability of > 100 DDR2 devices from Hynix, Samsung, and Micron. Detailed characterization of some devices when stressed by several data storage patterns was studied, targeting ability of the data cells to store the different data patterns without refresh, highlighting the weakest bits. DDR2, Reliability, Data Retention, Temperature Stress, Test System Evaluation, General Reliability, IDD measurements, electronic parts, parts testing, microcircuits

  13. Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer


    Terai, Hideki; Tan, Li; Beauchamp, Ellen M; Hatcher, John M.; Liu, Qingsong; Meyerson, Matthew; Gray, Nathanael S.; Hammerman, Peter S.


    Despite advances in precision medicine approaches over the past decade, the majority of nonsmall cell lung cancers (NSCLCs) are refractory to treatment with targeted small molecule inhibitors. Previous work has identified mutations in the Discoidin Domain Receptor 2 (DDR2) kinase as potential therapeutic targets in NSCLCs. While DDR2 is potently targeted by several multitargeted kinase inhibitors, most notably dasatinib, toxicity has limited the clinical application of anti-DDR2 therapy. Here...

  14. Inhibition of collagen fibrillogenesis by cells expressing soluble extracellular domains of DDR1 and DDR2. (United States)

    Flynn, Lisa A; Blissett, Angela R; Calomeni, Edward P; Agarwal, Gunjan


    Collagen fiber assembly affects many physiological processes and is tightly controlled by collagen-binding proteins. However, to what extent membrane-bound versus cell-secreted collagen-binding proteins affect collagen fibrillogenesis is not well understood. In our previous studies, we had demonstrated that the membrane-anchored extracellular domain (ECD) of the collagen receptor discoidin domain receptor 2 (DDR2) inhibits fibrillogenesis of collagen endogenously secreted by the cells. These results led to a novel functional role of the DDR2 ECD. However, since soluble forms of DDR1 and DDR2 containing its ECD are known to naturally exist in the extracellular matrix, in this work we investigated if these soluble DDR ECDs may have a functional role in modulating collagen fibrillogenesis. For this purpose, we created mouse osteoblast cell lines stably secreting DDR1 or DDR2 ECD as soluble proteins. Transmission electron microscopy, fluorescence microscopy, and hydroxyproline assays were used to demonstrate that DDR ECD expression reduced the rate and quantity of collagen deposition and induced significant changes in fiber morphology and matrix mineralization. Collectively, our studies advance our understanding of DDR receptors as powerful regulators of collagen deposition in the ECM and elucidate their multifaceted role in ECM remodeling.

  15. DDR2缓慢成长

    Institute of Scientific and Technical Information of China (English)



    按照Intel的计划,2004年应至少推出5种支持DDR2 SDRAM存储技术的芯片组。目前已经推出了支持DDR2 SDRAM存储器的芯片组——Grantsdale、Alderwood和Tumwater,它们分别用于台式机、工作站和服务器。而另外两款DDR2芯片组——Linenhurst和Airiso,它们分别用于服务器和移动系统的DDR2产品,目前还杳无音信,其中Alviso芯片组的发布已经确定被推迟到2005年初。

  16. Molecular analysis of collagen binding by the human discoidin domain receptors, DDR1 and DDR2. Identification of collagen binding sites in DDR2. (United States)

    Leitinger, Birgit


    The widely expressed mammalian discoidin domain receptors (DDRs), DDR1 and DDR2, are unique among receptor tyrosine kinases in that they are activated by the extracellular matrix protein collagen. Various collagen types bind to and activate the DDRs, but the molecular details of collagen recognition have not been well defined. In this study, recombinant extracellular domains of DDR1 and DDR2 were produced to explore DDR-collagen binding in detail. In solid phase assays, both DDRs bound collagen I with high affinity. DDR1 recognized collagen I only as a dimeric and not as a monomeric construct, indicating a requirement for receptor dimerization in the DDR1-collagen interaction. The DDRs contain a discoidin homology domain in their extracellular domains, and the isolated discoidin domain of DDR2 bound collagen I with high affinity. Furthermore, the discoidin domain of DDR2, but not of DDR1, was sufficient for transmembrane receptor signaling. To map the collagen binding site within the discoidin domain of DDR2, mutant constructs were created, in which potential surface-exposed loops in DDR2 were exchanged for the corresponding loops of functionally unrelated discoidin domains. Three spatially adjacent surface loops within the DDR2 discoidin domain were found to be critically involved in collagen binding of the isolated DDR2 extracellular domain. In addition, the same loops were required for collagen-dependent receptor activation. It is concluded that the loop region opposite to the polypeptide chain termini of the DDR2 discoidin domain constitutes the collagen recognition site.

  17. DDR3 SDRAM with a Complete Predictor (United States)

    Stankovic, Vladimir V.; Milenkovic, Nebojsa Z.

    In the arsenal of resources for improving computer memory system performance, predictors have gained an increasing role in the past few years. They enable hiding the latencies when accessing cache or main memory. In our previous work we proposed a DDR SDRAM controller with predictors that not only close the opened DRAM row but also predict the next row to be opened. In this paper we explore the possibilities of trying the same techniques on the latest type of DRAM memory, DDR3 SDRAM, with further improvements of the predictors.

  18. Use of Commercial FPGA-Based Evaluation Boards for Single-Event Testing of DDR2 and DDR3 SDRAMs (United States)

    Ladbury, R. L.; Berg, M. D.; Wilcox, E. P.; LaBel, K. A.; Kim, H. S.; Phan, A. M.; Seidleck, C. M.


    We investigate the use of commercial FPGA based evaluation boards for radiation testing DDR2 and DDR3 SDRAMs. We evaluate the resulting data quality and the tradeoffs involved in the use of these boards.

  19. Synthesis and biological evaluation of novel dasatinib analogues as potent DDR1 and DDR2 kinase inhibitors. (United States)

    Liu, Lu; Hussain, Muzammal; Luo, Jinfeng; Duan, Anna; Chen, Chaonan; Tu, Zhengchao; Zhang, Jiancun


    Novel dasatinib analogues as DDR1 and DDR2 inhibitors were designed and synthesized. The synthesized compounds were screened for DDR1 and DDR2 kinase inhibitory and cancer cell proliferation inhibitory activities. Some of the compounds showed the potent inhibitory activities against both DDR1 and DDR2, as well as anticancer activity in low nanomolar range against K562 cell line; especially, compound 3j demonstrated significantly better inhibitory potency than the parental dasatinib against both DDRs and also demonstrated the potent inhibitory activity against K562 cell lines (IC50 values of 2.26±0.46 nm for DDR1, 7.04±2.90 nm for DDR2, and 0.125±0.017 nm for K562 cell line).

  20. Radiation Hard Monolithic SDRAM to Support DDR2 and DDR3 Architectures Project (United States)

    National Aeronautics and Space Administration — Space Micro has developed the architecture for a radiation hardened memory subsystem that targets DDR3-and-beyond generations of DRAM. The architecture combines...

  1. DDR3、DDR2我该选哪个?

    Institute of Scientific and Technical Information of China (English)




  2. Stable cellular senescence is associated with persistent DDR activation. (United States)

    Fumagalli, Marzia; Rossiello, Francesca; Mondello, Chiara; d'Adda di Fagagna, Fabrizio


    The DNA damage response (DDR) is activated upon DNA damage generation to promote DNA repair and inhibit cell cycle progression in the presence of a lesion. Cellular senescence is a permanent cell cycle arrest characterized by persistent DDR activation. However, some reports suggest that DDR activation is a feature only of early cellular senescence that is then lost with time. This challenges the hypothesis that cellular senescence is caused by persistent DDR activation. To address this issue, we studied DDR activation dynamics in senescent cells. Here we show that normal human fibroblasts retain DDR markers months after replicative senescence establishment. Consistently, human fibroblasts from healthy aged donors display markers of DDR activation even three years in culture after entry into replicative cellular senescence. However, by extending our analyses to different human cell strains, we also observed an apparent DDR loss with time following entry into cellular senescence. This though correlates with the inability of these cell strains to survive in culture upon replicative or irradiation-induced cellular senescence. We propose a model to reconcile these results. Cell strains not suffering the prolonged in vitro culture stress retain robust DDR activation that persists for years, indicating that under physiological conditions persistent DDR is causally involved in senescence establishment and maintenance. However, cell strains unable to maintain cell viability in vitro, due to their inability to cope with prolonged cell culture-associated stress, show an only-apparent reduction in DDR foci which is in fact due to selective loss of the most damaged cells.

  3. DDR2 533〉DDR 400吗?——双通道DDR2和DDR的应用对比

    Institute of Scientific and Technical Information of China (English)



    一、DDR2和DDR 相比DDR内存,DDR2内存模组同样使用240pin,它最大的改进是采用了4位预取(Prefetch)架构。简单说,核心频率同样是100MHz的话,SDRAM内存的数据传输率是100Mbps,DDR是200Mbps,DDR2则可达到400Mbps.

  4. DDR2回归 DDR2系列显卡测试

    Institute of Scientific and Technical Information of China (English)


    继经典的GeForce FX 5800 Ultra之后,很长一段时间内鲜有厂商采用DDR2显存颗粒,主要原因是DDR2显存产量少,而且价格也比TSOP封装的DDR颗粒贵得多,而且当时生产工艺不成熟。颗粒发热较严重,不过这一情况随着DDR2量产以及Infineon(英飞凌)回归显存市场有了明显的变化。

  5. Tyrosine kinase discoidin domain receptors DDR1 and DDR2 are coordinately deregulated in triple-negative breast cancer. (United States)

    Toy, Kathy A; Valiathan, Rajeshwari R; Núñez, Fernando; Kidwell, Kelley M; Gonzalez, Maria E; Fridman, Rafael; Kleer, Celina G


    Receptor kinases Discoidin Domain Receptors (DDRs) 1 and 2 are emerging as new therapeutic targets in breast cancer (BC). However, the expression of DDR proteins during BC progression and their association with BC subtypes remain poorly defined. Herein we report the first comprehensive immunohistochemical analyses of DDR protein expression in a wide range of breast tissues. DDR1 and DDR2 expression was investigated by immunohistochemistry in 218 samples of normal breast (n = 10), ductal carcinoma in situ (DCIS, n = 10), and invasive carcinomas (n = 198), arrayed in tissue microarrays with comprehensive clinical and follow-up information. Staining was evaluated for cell type, subcellular localization, percentage and intensity (scores 1-4), and association with disease subtype and outcome. In normal epithelium and DCIS, DDR1 was highly expressed, while DDR2 was negative in normal epithelium, and in DCIS it localized to cells at the epithelial-stromal interface. Of the 198 invasive carcinomas, DDR1 was high in 87 (44 %) and low in 103 (52 %), and DDR2 was high in 110 (56 %) and low in 87 (44 %). High DDR2 was associated with high tumor grade (P = 0.002), triple-negative subtype (TNBC) (P DDR2(High) profile significantly associated with TNBC, compared to luminal tumors (P = 0.012), and with worse overall survival. In conclusion, DDR2 upregulation occurs in DCIS, before stromal invasion, and may reflect epithelial-stromal cross-talk. A DDR1(Low)/DDR2(High) protein profile is associated with TNBC and may identify invasive carcinomas with worse prognosis.

  6. DDR2-800内存惹了谁

    Institute of Scientific and Technical Information of China (English)


    额滴神呀!DDR2-800太便宜了!历过一年的“跌跌不休”,1GB DDR2-800终于跌到了仅比DDR2-667贵30元左右的价位上(大多在200元左右)。尽管还不能说DDR2-667就此退出市场,但DDR2-800无疑更能吸引大家的目光。现在,各品牌的DDR2-800内存已大量上市,谁才是众神之神?PCD小编为你做出鉴定。

  7. DDR2内存超频初探

    Institute of Scientific and Technical Information of China (English)



    DDR2内存进手桌面PC是2004年的事情2004年6月20日发布的Intel 9xx芯片组提供了对DDR2内存的全面支持。不过,由于初期DDR2内存价格的居高不下(256MB DDR2的价格相当于512MB的DDR内存)DDR2市场异常低迷进入2005年后.Intel加大了DDR2芯片组的出货比例,三星、

  8. Coercive Disarmament, Demobilization and Reintegration (DDR): Can It Be Successful (United States)


    DEMOBLIZATION AND REINTEGRATION (DDR): CAN IT BE SUCCESSFUL ? by Shane R. Doolan March 2008 Thesis Co-Advisors: Jeanne Giraldo...DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE Coercive Disarmament Demobilization and Reintegration (DDR): Can it be Successful ? 6. AUTHOR(S...DISARMAMENT DEMOBILIZATION AND REINTEGRATION (DDR): CAN IT BE SUCCESSFUL ? Shane R. Doolan Captain, United States Army B.S., Police Studies, John Jay

  9. A-DATA DDR2 800内存

    Institute of Scientific and Technical Information of China (English)



    威刚红色威龙系列的A-DATA DDR2 800以出色的做工和性能优势,显现出DDR2 800规格在双核系统下的强大优势。先来看做工,A-DATA DDR2 800加装了大家熟悉的红色散热片,

  10. DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1


    Xie, Binhui; Lin, Weihao; Ye, Junming; Wang, Xiaonong; Zhang, Bing; Xiong, Shiqiu; Li, Heping; Tan, Guosheng


    Background Several studies have found that DDR2 is up-regulated in many tumor types and facilitates tumor progression. However, the role of DDR2 in hepatocellular carcinoma (HCC) progression and its downstream signaling pathways remain unclear. Methods DDR2 expression was assessed in several cell lines and 112 pairs of HCC and matched adjacent noncancerous liver tissues. Clinical significance of DDR2 in HCC was analyzed. Phosphorylated DDR2 (p-DDR2) expression was detected by immunoblotting t...

  11. DDR2 VS. DDR——两代内存性能大比拼

    Institute of Scientific and Technical Information of China (English)



    DDR2粉丝团:虽然以前DDR2 400的性能比DDR 400差不少,但DDR 533出现以后,DDR的性能优势就不再明显了,更不要说DDR2 667了,性能更是超越了DDR 400领先了很多。

  12. Stat uden folk. Det nationale problem i DDR

    DEFF Research Database (Denmark)

    Lammers, Karl Christian


    Artikel om det store identitetsproblem i DDR. Nemlig etableringen af en national identitet. Det forsøgte man forgæves med skabelsen af "den socialistiske nation". Udgivelsesdato: 1990......Artikel om det store identitetsproblem i DDR. Nemlig etableringen af en national identitet. Det forsøgte man forgæves med skabelsen af "den socialistiske nation". Udgivelsesdato: 1990...

  13. Xilinx DDR2 IP核控制器设计%Design of Xilinx DDR2 IP Controller

    Institute of Scientific and Technical Information of China (English)

    邹连英; 余峰


    提出一种便于用户操作并能快速运用到产品的DDR2控制器IP核的FPGA实现,使用户不需要了解DDR2的原理和操作方式的情况下,依然可以通过IP核控制DDR2。简单介绍了DDR2的特点和操作原理,并对DDR2控制器的IP核进行了模块化的划分,分析了每个模块的功能。强调了用户接口功能的完善,并介绍了IP核的操作流程,使每个用户都能轻松的使用该IP核。%This paper presents a DDR2 Controller IP core of FPGA implementation which user-friendly and quickly applied to the product. The IP core allows the user does not need to understand the principles and practices DDR2 circumstances, and can still control the DDR2. This thesis briefly introduces that the characteristics and operating principles of DDR2, and analyze that the function of each module in the DDR2 controller IP core. Emphasized the function of the perfect user interface, described the IP core operational processes in the paper, so that each user can easily use the IP core.

  14. 只能使用DDR3内存的DDR2主板盈通A785G战警版

    Institute of Scientific and Technical Information of China (English)




  15. Discoidin domain receptor 2 (DDR2) regulates proliferation of endochondral cells in mice

    Energy Technology Data Exchange (ETDEWEB)

    Kawai, Ikuma; Hisaki, Tomoka; Sugiura, Koji; Naito, Kunihiko [Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo 113-8657 (Japan); Kano, Kiyoshi, E-mail: [Laboratory of Developmental Biology, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan. (Japan); Biomedical Science Center for Translational Research (BSCTR), The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515 (Japan)


    Highlights: Black-Right-Pointing-Pointer Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase. Black-Right-Pointing-Pointer DDR2 regulates cell proliferation, cell adhesion, migration, and extracellular matrix remodeling. Black-Right-Pointing-Pointer We produced in vitro and in vivo model to better understand the role of DDR2. Black-Right-Pointing-Pointer DDR2 might play an inhibitory role in the proliferation of chondrocyte. -- Abstract: Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase that is activated by fibrillar collagens. DDR2 regulates cell proliferation, cell adhesion, migration, and extracellular matrix remodeling. The decrement of endogenous DDR2 represses osteoblastic marker gene expression and osteogenic differentiation in murine preosteoblastic cells, but the functions of DDR2 in chondrogenic cellular proliferation remain unclear. To better understand the role of DDR2 signaling in cellular proliferation in endochondral ossification, we inhibited Ddr2 expression via the inhibitory effect of miRNA on Ddr2 mRNA (miDdr2) and analyzed the cellular proliferation and differentiation in the prechondrocyte ATDC5 cell lines. To investigate DDR2's molecular role in endochondral cellular proliferation in vivo, we also produced transgenic mice in which the expression of truncated, kinase dead (KD) DDR2 protein is induced, and evaluated the DDR2 function in cellular proliferation in chondrocytes. Although the miDdr2-transfected ATDC5 cell lines retained normal differentiation ability, DDR2 reduction finally promoted cellular proliferation in proportion to the decreasing ratio of Ddr2 expression, and it also promoted earlier differentiation to cartilage cells by insulin induction. The layer of hypertrophic chondrocytes in KD Ddr2 transgenic mice was not significantly thicker than that of normal littermates, but the layer of proliferative chondrocytes in KD-Ddr2 transgenic mice was significantly thicker than that of normal littermates

  16. DDR2,该出手时就出手

    Institute of Scientific and Technical Information of China (English)




  17. DDR2 plays a role in fibroblast migration independent of adhesion ligand and collagen activated DDR2 tyrosine kinase. (United States)

    Herrera-Herrera, Mireya Liliana; Quezada-Calvillo, Roberto


    Discoidin domain receptor-2 (DDR2) is a cell surface tyrosine kinase receptor that can be activated by soluble collagen and has been implicated in diverse physiological functions including organism growth and wound repair. In the current studies, we used fibronectin and collagen-coated 2D surfaces and collagen matrices in combination with siRNA technology to investigate the role of DDR2 in a range of fibroblast motile activities. Silencing DDR2 with siRNA inhibited cell spreading and migration, and similar inhibition occurred regardless whether cells were interacting with fibronectin or collagen surfaces. Under the assay conditions used, DDR2 tyrosine kinase activation was not observed unless soluble collagen was added to the incubation medium. Finally silencing DDR2 also inhibited human fibroblast migration in 3D collagen matrices but had no effect on 3D collagen matrix remodeling and contraction. Taken together, our findings suggest that DDR2 is required for normal fibroblast spreading and migration independent of adhesion ligand and collagen activation of DDR2 tyrosine kinase.

  18. DdrA, DdrD, and PprA: components of UV and mitomycin C resistance in Deinococcus radiodurans R1.

    Directory of Open Access Journals (Sweden)

    Kathiresan Selvam

    Full Text Available Mutants created by deleting the ddrA, ddrB, ddrC, ddrD, and pprA loci of Deinococcus radiodurans R1alone and in all possible combinations of pairs revealed that the encoded gene products contribute to this species' resistance to UV light and/or mitomycin C. Deleting pprA from an otherwise wild type cell sensitizes the resulting strain to UV irradiation, reducing viability by as much as eight fold relative to R1. If this deletion is introduced into a ΔddrA or ΔddrD background, the resulting strains become profoundly sensitive to the lethal effects of UV light. At a fluence of 1000 Jm⁻², the ΔddrA ΔpprA and ΔddrD ΔpprA strains are 100- and 1000-fold more sensitive to UV relative to the strain that has only lost pprA. Deletion of ddrA results in a 100 fold increase in strain sensitivity to mitomycin C, but in backgrounds that combine a deletion of ddrA with deletions of either ddrC or ddrD, mitomycin resistance is restored to wild type levels. Inactivation of ddrB also increases D. radiodurans sensitivity to mitomycin, but unlike the ddrA mutant deleting ddrC or ddrD from a ΔddrB background further increases that sensitivity. Despite the effect that loss of these gene products has on DNA damage resistance, none appear to directly affect either excision repair or homologous recombination suggesting that they participate in novel processes that facilitate tolerance to UV light and interstrand crosslinks in this species.

  19. DDR2 667渐入主流——金士刚DDR2 667内存

    Institute of Scientific and Technical Information of China (English)



    随着lntel新架构的成熟,DDR2内存和PCI-E显卡、SATA硬盘逐渐成为主流配置。而技术的成熟让DDR2也逐渐提升频率,较新的i945/955、nForce4 IE和ATlRC410等芯片组也提供了对DDR2 667的支持。

  20. ADATA Vitesta DDR2 1066内存

    Institute of Scientific and Technical Information of China (English)


    在推出了DDR2 800内存之后,ADATA再接再励,新款的DDR2 1066内存也于最近登台亮相,成为第一款正式上市的DDR2 1066内存产品。ADATA Vitesta DDR2 1066内存属于ADATA红色威龙系列,单条容量为256MB.采用了单面8颗FBGA封装的32M×8(256Mbit)内存颗粒设计,标准工作频率为1066MHz,默认内存CL延迟值为5,可以提供高达85GB/s的数据带宽。

  1. The Design of DDR2 SDRAM Controller and Implementation in FPGA%DDR2 SDRAM控制器的设计及FPGA验证

    Institute of Scientific and Technical Information of China (English)

    刘冠男; 欧明双; 宋何娟


    根据DDR2 SDRAM的技术规范,介绍了DDR2的基本特征和工作原理,提出了一种DDR2控制器的设计方法,详述了DDR2控制器的工作原理和功能结构,并在FPGA上验证了设计的正确性.

  2. DDR2 VS. DDR——DDR2/DDR平台成本大比拼

    Institute of Scientific and Technical Information of China (English)




  3. 330元也能买DDR2 667——富豪DDR2 667 512MB内存

    Institute of Scientific and Technical Information of China (English)


    目前512MB DDR2 533品牌内存的价格一般在320元左右,DDR2 667的价格一般要贵上50元~100元。不过最近富豪DDR2 667 512MB内存上市.价格只要330元。以DDR2 533内存的价格就能买到DDR2 667的内存,

  4. Discoidin domain receptor 2 (DDR2) regulates proliferation of endochondral cells in mice. (United States)

    Kawai, Ikuma; Hisaki, Tomoka; Sugiura, Koji; Naito, Kunihiko; Kano, Kiyoshi


    Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase that is activated by fibrillar collagens. DDR2 regulates cell proliferation, cell adhesion, migration, and extracellular matrix remodeling. The decrement of endogenous DDR2 represses osteoblastic marker gene expression and osteogenic differentiation in murine preosteoblastic cells, but the functions of DDR2 in chondrogenic cellular proliferation remain unclear. To better understand the role of DDR2 signaling in cellular proliferation in endochondral ossification, we inhibited Ddr2 expression via the inhibitory effect of miRNA on Ddr2 mRNA (miDdr2) and analyzed the cellular proliferation and differentiation in the prechondrocyte ATDC5 cell lines. To investigate DDR2's molecular role in endochondral cellular proliferation in vivo, we also produced transgenic mice in which the expression of truncated, kinase dead (KD) DDR2 protein is induced, and evaluated the DDR2 function in cellular proliferation in chondrocytes. Although the miDdr2-transfected ATDC5 cell lines retained normal differentiation ability, DDR2 reduction finally promoted cellular proliferation in proportion to the decreasing ratio of Ddr2 expression, and it also promoted earlier differentiation to cartilage cells by insulin induction. The layer of hypertrophic chondrocytes in KD Ddr2 transgenic mice was not significantly thicker than that of normal littermates, but the layer of proliferative chondrocytes in KD-Ddr2 transgenic mice was significantly thicker than that of normal littermates. Taken together, our data demonstrated that DDR2 might play a local and essential role in the proliferation of chondrocytes.

  5. 讯景6600 DDR2荣誉版

    Institute of Scientific and Technical Information of China (English)



    XFX(讯景)近日推出了一款6600 DDR2 256MB荣誉版,与先前的6600系列显卡不同,该产品配备256MB DDR2显存,核心/显存频率为较高的400/800MHz,且采用NVIDIA最新的P295公版PCB。6600 DDR2版沿用了XFX传统的深蓝色PCB,采用8频英飞凌2.5ns GDDR2显存,组成256MB/128bit规格。

  6. Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth

    Directory of Open Access Journals (Sweden)

    Maria E. Gonzalez


    Full Text Available Increased collagen deposition by breast cancer (BC-associated mesenchymal stem/multipotent stromal cells (MSC promotes metastasis, but the mechanisms are unknown. Here, we report that the collagen receptor discoidin domain receptor 2 (DDR2 is essential for stromal-BC communication. In human BC metastasis, DDR2 is concordantly upregulated in metastatic cancer and multipotent mesenchymal stromal cells. In MSCs isolated from human BC metastasis, DDR2 maintains a fibroblastic phenotype with collagen deposition and induces pathological activation of DDR2 signaling in BC cells. Loss of DDR2 in MSCs impairs their ability to promote DDR2 phosphorylation in BC cells, as well as BC cell alignment, migration, and metastasis. Female ddr2-deficient mice homozygous for the slie mutation show inefficient spontaneous BC metastasis. These results point to a role for mesenchymal stem cell DDR2 in metastasis and suggest a therapeutic approach for metastatic BC.

  7. Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth. (United States)

    Gonzalez, Maria E; Martin, Emily E; Anwar, Talha; Arellano-Garcia, Caroline; Medhora, Natasha; Lama, Arjun; Chen, Yu-Chih; Tanager, Kevin S; Yoon, Euisik; Kidwell, Kelley M; Ge, Chunxi; Franceschi, Renny T; Kleer, Celina G


    Increased collagen deposition by breast cancer (BC)-associated mesenchymal stem/multipotent stromal cells (MSC) promotes metastasis, but the mechanisms are unknown. Here, we report that the collagen receptor discoidin domain receptor 2 (DDR2) is essential for stromal-BC communication. In human BC metastasis, DDR2 is concordantly upregulated in metastatic cancer and multipotent mesenchymal stromal cells. In MSCs isolated from human BC metastasis, DDR2 maintains a fibroblastic phenotype with collagen deposition and induces pathological activation of DDR2 signaling in BC cells. Loss of DDR2 in MSCs impairs their ability to promote DDR2 phosphorylation in BC cells, as well as BC cell alignment, migration, and metastasis. Female ddr2-deficient mice homozygous for the slie mutation show inefficient spontaneous BC metastasis. These results point to a role for mesenchymal stem cell DDR2 in metastasis and suggest a therapeutic approach for metastatic BC.

  8. Structure and functional analysis of the multistress response gene DDR2 from Saccharomyces cerevisiae. (United States)

    Kobayashi, N; McClanahan, T K; Simon, J R; Treger, J M; McEntee, K


    The DDR2 gene is a multistress response gene in Saccharomyces cerevisiae that is transcriptionally activated by more than thirteen xenobiotic agents and environmental or physiological stresses. The DDR2 gene encodes a small hydrophobic 61 amino acid polypeptide located on chromosome XV adjacent to the SPE2 locus. Disruption alleles of the DDR2 gene have been constructed and these ddr2 delta mutants show no defect in heat shock recovery or thermotolerance and appear normal for DNA damage sensitivity and mutagenesis.

  9. Prognostic significance of discoidin domain receptor 2 (DDR2) expression in ovarian cancer


    Fan, Yi; Xu, Zhe; Fan, Jin; Huang, Liu; Ye, Ming; Shi, Kun; Huang, Zheng; Liu, Yaqiong; He, Langchi; Huang, Jiezhen; Wang, Yibin; Li, Qiufeng


    Increasing evidence has suggested that discoidin domain receptor 2 (DDR2) plays an important role in cancer development and metastasis. However, the correlation between DDR2 expression and clinical outcome in ovarian cancer has not been investigated. In this study, DDR2 expression was examined by Real-time PCR in surgically resected ovarian cancer and normal ovary tissues. Besides, DDR2 expression was analyzed immunohistochemically in 103 ovarian cancer patients, and the correlation between D...

  10. Collagen I induces discoidin domain receptor (DDR) 1 expression through DDR2 and a JAK2-ERK1/2-mediated mechanism in primary human lung fibroblasts. (United States)

    Ruiz, Pedro A; Jarai, Gabor


    Discoidin domain receptors (DDRs) DDR1 and DDR2 are receptor tyrosine kinases with the unique ability among receptor tyrosine kinases to respond to collagen. Several signaling molecules have been implicated in DDR signaling, including Shp-2, Src, and MAPK pathways, but a detailed understanding of these pathways and their transcriptional targets is still lacking. Similarly, the regulation of the expression of DDRs is poorly characterized with only a few inflammatory mediators, such as lipopolysaccharide and interleukin-1β identified as playing a role in DDR1 expression. DDRs have been reported to induce the expression of various genes including matrix metalloproteinases and bone morphogenetic proteins, but the regulatory mechanisms underlying DDR-induced gene expression remain to be determined. The aim of the present work was to elucidate the molecular mechanisms implicated in the expression of DDRs and to identify DDR-induced signaling pathways and target genes. Our data show that collagen I induces the expression of DDR1 in a dose- and time-dependent manner in primary human lung fibroblasts. Furthermore, activation of DDR2, JAK2, and ERK1/2 MAPK signaling pathways was essential for collagen I-induced DDR1 and matrix metalloproteinase 10 expression. Finally, inhibition of the ERK1/2 pathway abrogated DDR1 expression by blocking the recruitment of the transcription factor polyoma enhancer A-binding protein 3 to the DDR1 promoter. Our data provide new insights into the molecular mechanisms of collagen I-induced DDR1 expression and demonstrate an important role for ERK1/2 activation and the recruitment of polyoma enhancer-A binding protein 3 to the DDR1 promoter.

  11. From DDR to Security Promotion: Connecting national programs to community initiatives

    NARCIS (Netherlands)

    Verkoren, W.; Willems, R.C.; Kleingeld, J.; Rouw, H.


    Disarmament, demobilization and reintegration (DDR) is a set of activities that forms part of strategies for peacebuilding after civil war. DDR has become the standard way of addressing security threats in immediate post-conflict situations. However, DDR is designed to promote national security, rat

  12. DDR2新力量——超胜DDR2-533白金条

    Institute of Scientific and Technical Information of China (English)



    虽然Intel推出i925X,i915G/P系列芯片已有5个月,但PCI-E总线系统的普及还是备受价格困扰。经过一段时间走高之后,DDR2内存价格逐渐达到较合理的程度,主流的256MB DDR2-533内存在600元左右。

  13. Connecting Community Security and DDR: Experiences from Eastern DRC

    NARCIS (Netherlands)

    Willems, R.C.; Rouw, H.


    The report is based on 11 weeks of field research in Ituri and the Kivus between September and December 2009, and looks at the linkages between community security and DDR in the case of eastern DRC. To assess this relation , the report starts with an analysis of what security is considered to entail

  14. Identification of type II and III DDR2 inhibitors. (United States)

    Richters, André; Nguyen, Hoang D; Phan, Trang; Simard, Jeffrey R; Grütter, Christian; Engel, Julian; Rauh, Daniel


    Discoidin domain-containing receptors (DDRs) exhibit a unique mechanism of action among the receptor tyrosine kinases (RTKs) because their catalytic activity is induced by extracellular collagen binding. Moreover, they are essential components in the assimilation of extracellular signals. Recently, DDRs were reported to be significantly linked to tumor progression in breast cancer by facilitating the processes of invasion, migration, and metastasis. Here, we report the successful development of a fluorescence-based, direct binding assay for the detection of type II and III DFG-out binders for DDR2. Using sequence alignments and homology modeling, we designed a DDR2 construct appropriate for fluorescent labeling. Successful assay development was validated by sensitive detection of a reference DFG-out binder. Subsequent downscaling led to convenient application to high-throughput screening formats. Screening of a representative compound library identified high-affinity DDR2 ligands validated by orthogonal activity-based assays, and a subset of identified compounds was further investigated with respect to DDR1 inhibition.

  15. DDR2 (discoidin domain receptor 2) suppresses osteoclastogenesis and is a potential therapeutic target in osteoporosis. (United States)

    Zhang, Yan; Su, Jin; Wu, Shufang; Teng, Yue; Yin, Zhanhai; Guo, Yan; Li, Jing; Li, Kun; Yao, Libo; Li, Xu


    Osteoporosis is a disease characterized by abnormal skeletal fragility due to an imbalance in bone homeostasis. Finding therapeutic targets that promote bone formation is valuable for treating osteoporosis. Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase that promotes the differentiation of bone-depositing cells, osteoblasts, and bone formation. We investigated the role of DDR2 in osteoclastogenesis, the formation of cells responsible for bone resorption. We found that, although differentiated osteoclasts had catalytically active DDR2, its abundance was decreased. Overexpression of DDR2 inhibited the expression of osteoclastic markers, osteoclast maturation, and osteoclast-mediated bone resorption in a culture model of bone matrix. Conversely, knocking down Ddr2 through RNA interference accelerated osteoclast differentiation and bone resorption in mice. Further, we identified the co-receptor Neuropilin-1 (Nrp1) as a DDR2-interacting protein. DDR2 facilitated the binding of Nrp1 and the co-receptor PlexinA1 by forming a DDR2-Nrp1-PlexinA1 complex, which blocked PlexinA1-mediated stimulation of osteoclastogenesis. DDR2 prevented PlexinA1 from interacting with the receptor TREM2 and the adaptor DAP12. Moreover, knocking down Nrp1 rescued the expression of osteoclastic markers observed in DDR2-overexpressing cells, whereas ectopic expression of Nrp1 in DDR2-silenced cells inhibited the induction of osteoclastogenesis. Nrp1 enhanced the function of DDR2 in promoting osteoblast differentiation and bone formation in mice. In an ovariectomized mouse model of osteoporosis, adenovirus-mediated delivery of DDR2 to the femur bone alleviated osteopenic phenotypes. Our results revealed that DDR2 functions as an inhibitor of osteoclastogenesis, as well as a promoter of osteoblastogenesis, suggesting that enhancing DDR2 may be therapeutic for patients with osteoporosis.

  16. The discoidin domain receptor DDR2 is a receptor for type X collagen. (United States)

    Leitinger, Birgit; Kwan, Alvin P L


    During endochondral ossification, collagen X is deposited in the hypertrophic zone of the growth plate. Our previous results have shown that collagen X is capable of interacting directly with chondrocytes, primarily via integrin alpha2beta1. In this study, we determined whether collagen X could also interact with the non-integrin collagen receptors, discoidin domain receptors (DDRs), DDR1 or DDR2. The widely expressed DDRs are receptor tyrosine kinases that are activated by a number of different collagen types. Collagen X was found to be a much better ligand for DDR2 than for DDR1. Collagen X bound to the DDR2 extracellular domain with high affinity and stimulated DDR2 autophosphorylation, the first step in transmembrane signalling. Expression of DDR2 in the epiphyseal plate was confirmed by RT-PCR and immunohistochemistry. The spatial expression of DDR2 in the hypertrophic zone of the growth plate is consistent with a physiological interaction of DDR2 with collagen X. Surprisingly, the discoidin domain of DDR2, which fully contains the binding sites for the fibrillar collagens I and II, was not sufficient for collagen X binding. The nature of the DDR2 binding site(s) within collagen X was further analysed. In addition to a collagenous domain, collagen X contains a C-terminal NC1 domain. DDR2 was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR2 autophosphorylation was induced by the collagen X triple-helical region but not the NC1 domain, indicating that the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation. Our study is the first to describe a non-fibrillar collagen ligand for DDR2 and will form the basis for further studies into the biological function of collagen X during endochondral ossification.

  17. Nrp1, a Neuronal Regulator, Enhances DDR2-ERK-Runx2 Cascade in Osteoblast Differentiation via Suppression of DDR2 Degradation

    Directory of Open Access Journals (Sweden)

    Yan Zhang


    Full Text Available Background: Osteoblastogenesis is under delicate control by multiple factors and hormones. Recent reports indicated the involvement of immunological and neuronal regulators. However, the role of neuropilin 1 (Nrp1 in osteoblastogenesis remains obscure. Methods: Real-time PCR was carried out to detect the mRNA of osteoblastic markers, Nrp1, and discoidin domain receptor 2 (DDR2. Immunoblot was performed to test the protein of Nrp1 and DDR2. Osteogenic differentiation was evaluated by mRNA analysis of osteogenic markers, and determination of ALP activity and OCN secretion. The intercellular signaling effectors were examined by immunoblot. Immunofluorescent assays were performed to detect the localization of Nrp1 and DDR2. Half-life determination assay was executed to test the DDR2 stability. Results: The expression of Nrp1 paralleled with that of DDR2 during osteoblastogensis. Nrp1 overexpression enhanced DDR2-induced stimulation of osteoblastogensis, whereas Nrp1 silencing caused attenuation. Nrp1 overexpression increased the phosphorylation of DDR2, ERK1/2 and Runx2. Nrp1 co-localized with DDR2 in the cellular membrane of differentiated MC3T3-E1. Enhanced or attenuated Nrp1 expression did not alter the mRNA transcript of DDR2. Nrp1 overexpression prolonged the half-life of DDR2 protein. Conclusion: Our results originally demonstrated the stimulatory role of Nrp1 in DDR2-induced osteoblast differentiation, providing molecular evidence for exploiting Nrp1 and DDR2 as targets to treat bone-related disease.

  18. Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen. (United States)

    Konitsiotis, Antonios D; Raynal, Nicolas; Bihan, Dominique; Hohenester, Erhard; Farndale, Richard W; Leitinger, Birgit


    The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases that are activated by native triple-helical collagen. Here we have located three specific DDR2 binding sites by screening the entire triple-helical domain of collagen II, using the Collagen II Toolkit, a set of overlapping triple-helical peptides. The peptide sequence that bound DDR2 with highest affinity interestingly contained the sequence for the high affinity binding site for von Willebrand factor in collagen III. Focusing on this sequence, we used a set of truncated and alanine-substituted peptides to characterize the sequence GVMGFO (O is hydroxyproline) as the minimal collagen sequence required for DDR2 binding. Based on a recent NMR analysis of the DDR2 collagen binding domain, we generated a model of the DDR2-collagen interaction that explains why a triple-helical conformation is required for binding. Triple-helical peptides comprising the DDR2 binding motif not only inhibited DDR2 binding to collagen II but also activated DDR2 transmembrane signaling. Thus, DDR2 activation may be effected by single triple-helices rather than fibrillar collagen.

  19. DDR2内存的现状及选购

    Institute of Scientific and Technical Information of China (English)



    从2005年下半年开始,DDR2内存的价格开始持续走低,DDR2 533的价格甚至低于DDR 400,再加上DDR2 667和DDR2 800内存的跟进,内存变革的序幕已经拉开。现在消费者在购买内存的时候经常就在考虑一个问题,我所购买的CPU是否支持DDR2内存,现在市场中卖得火热的Sempron,Athlon64处理器能和DDR2内存搭配吗?通过本文也许您就能从中找到答案。

  20. Collagen binding specificity of the discoidin domain receptors: Binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1


    Xu, Huifang; Raynal, Nicolas; Stathopoulos, Stavros; Myllyharju, Johanna; Farndale, Richard W.; Leitinger, Birgit


    The discoidin domain receptors, DDR1 and DDR2 are cell surface receptor tyrosine kinases that are activated by triple-helical collagen. While normal DDR signalling regulates fundamental cellular processes, aberrant DDR signalling is associated with several human diseases. We previously identified GVMGFO (O is hydroxyproline) as a major DDR2 binding site in collagens I–III, and located two additional DDR2 binding sites in collagen II. Here we extend these studies to the homologous DDR1 and the...

  1. 基于Hyperlynx的DDR2嵌入式系统设计与仿真%Design and simulation of DDR2 embedded system based on Hyperlynx

    Institute of Scientific and Technical Information of China (English)




  2. Prognostic significance of discoidin domain receptor 2 (DDR2) expression in ovarian cancer. (United States)

    Fan, Yi; Xu, Zhe; Fan, Jin; Huang, Liu; Ye, Ming; Shi, Kun; Huang, Zheng; Liu, Yaqiong; He, Langchi; Huang, Jiezhen; Wang, Yibin; Li, Qiufeng


    Increasing evidence has suggested that discoidin domain receptor 2 (DDR2) plays an important role in cancer development and metastasis. However, the correlation between DDR2 expression and clinical outcome in ovarian cancer has not been investigated. In this study, DDR2 expression was examined by Real-time PCR in surgically resected ovarian cancer and normal ovary tissues. Besides, DDR2 expression was analyzed immunohistochemically in 103 ovarian cancer patients, and the correlation between DDR2 expression with clinicopathologic factors was analyzed. The result showed that DDR2 mRNA expression was upregulated in ovarian cancer tissues compared with normal ovary tissues. Statistical analysis revealed that DDR2 expression correlated with tumor stage (P = 0.008) and peritoneal metastasis (P = 0.009). Patients with high DDR2 expression showed poorer 5-year overall survival (P = 0.005), and DDR2 remained an independent prognostic marker for OS (P = 0.013) in multivariate analysis. Our results suggest that DDR2 might be closely associated with ovarian cancer progression and metastasis. Its high expression may serve as a potential prognostic biomarker in human ovarian cancer.

  3. DDR2 polymorphisms and mRNA expression in lung cancers of Japanese patients. (United States)

    Sasaki, Hidefumi; Shitara, Masayuki; Yokota, Keisuke; Okuda, Katsuhiro; Hikosaka, Yu; Moriyama, Satoru; Yano, Motoki; Fujii, Yoshitaka


    Discoidin domain receptor 2, DDR2, is a tyrosine kinase receptor for fibrillar collagen that is involved in postnatal development, tissue repair and primary and metastatic cancer progression. Recently, mutations in the DDR2 kinase gene were identified in squamous cell lung cancer from large-scale Sanger sequencing. The present study investigated the DDR2 gene mutations and mRNA expression in surgically treated non-small cell lung cancer (NSCLC) of squamous histology cases. The presence or absence of DDR2 mutations at the kinase and discoidin domain was analyzed by direct sequencing. In this cohort, DDR2 mutations were not observed in the 166 patients with lung cancer, although DDR2 polymorphisms were observed (H136H, n=14) at the discoidin domain. mRNA levels of DDR2 in lung tumor samples and the adjacent normal lung samples were simultaneously analyzed. DDR2 mRNA levels were significantly decreased in tumor samples compared with normal lung samples. However, the DDR2 mRNA levels were elevated in the DDR2 polymorphism cases.

  4. Discoidin domain receptor 2 (DDR2) is required for maintenance of spermatogenesis in male mice. (United States)

    Kano, Kiyoshi; Kitamura, Ayami; Matsuwaki, Takashi; Morimatsu, Masami; Naito, Kunihiko


    Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase (RTK). We recently identified homozygous smallie mutant mice (BKS.HRS. Ddr2(slie/slie)/J, Ddr2(slie/slie) mutants), which lack a functional DDR2. Ddr2(slie/slie) mutant mice are dwarfed and infertile due to peripheral dysregulation of the endocrine system. To understand the role of DDR2 signaling in spermatogenesis, we studied the expression of several receptors, enzymes, and proteins related to spermatogenesis in wild-type and Ddr2(slie/slie) mutant mice at 10 weeks and 5 months of age. DDR2 were expressed in adult wild-type male mice in Leydig cells. The number of differentiated spermatozoa in the seminal fluid was significantly lower in the Ddr2(slie/slie) mutant mice than in the wild-type mice. The number of TUNEL-positive cells was significantly greater in 5-month-old Ddr2(slie/slie) mutants. Testosterone was significantly reduced at 5 months of age, but LH was similar in both types of mice at both 10 weeks and 5 months of age. The expression levels of LH receptors (Lhcgr), StAR, P450scc, and Hsd3beta6 were not significantly different between the two types of mice at 10 weeks of age, but they were significantly reduced in 5-month-old Ddr2(slie/slie) mutants compared to wild-type mice of the same age. DDR2 was expressed in the Leydig cells of adult wild-type male mice. In conclusion, our results indicated that DDR2 signaling plays a critical role in the maintenance of male spermatogenesis.

  5. The Lessons and Limits of DDR in Africa (United States)


    among ex-combatants remain common in many DDR campaigns. THE COMBATANT’S VIEW Combatants in postconflict settings can be roughly divided into three...flated expectations about its outcomes, which can result in later frustration. However, with proper planning , the disarmament and demobilization steps...integrate into civilian communities.7 In general, mismatches between reintegration plans and the opportunities, skills, prefer- ences, and expectations of

  6. The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. (United States)

    Labrador, J P; Azcoitia, V; Tuckermann, J; Lin, C; Olaso, E; Mañes, S; Brückner, K; Goergen, J L; Lemke, G; Yancopoulos, G; Angel, P; Martínez, C; Klein, R


    The discoidin domain receptor 2 (DDR2) is a member of a subfamily of receptor tyrosine kinases whose ligands are fibrillar collagens, and is widely expressed in postnatal tissues. We have generated DDR2-deficient mice to establish the in vivo functions of this receptor, which have remained obscure. These mice exhibit dwarfism and shortening of long bones. This phenotype appears to be caused by reduced chondrocyte proliferation, rather than aberrant differentiation or function. In a skin wound healing model, DDR2-/- mice exhibit a reduced proliferative response compared with wild-type littermates. In vitro, fibroblasts derived from DDR2-/- mutants proliferate more slowly than wild-type fibroblasts, a defect that is rescued by introduction of wild-type but not kinase-dead DDR2 receptor. Together our results suggest that DDR2 acts as an extracellular matrix sensor to modulate cell proliferation.

  7. DDR2降价后如何选购显卡

    Institute of Scientific and Technical Information of China (English)




  8. Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth


    Gonzalez, Maria E.; Martin, Emily E.; Talha Anwar; Caroline Arellano-Garcia; Natasha Medhora; Arjun Lama; Yu-Chih Chen; Kevin S. Tanager; Euisik Yoon; Kidwell, Kelley M.; Chunxi Ge; Franceschi, Renny T.; Celina G. Kleer


    Increased collagen deposition by breast cancer (BC)-associated mesenchymal stem/multipotent stromal cells (MSC) promotes metastasis, but the mechanisms are unknown. Here, we report that the collagen receptor discoidin domain receptor 2 (DDR2) is essential for stromal-BC communication. In human BC metastasis, DDR2 is concordantly upregulated in metastatic cancer and multipotent mesenchymal stromal cells. In MSCs isolated from human BC metastasis, DDR2 maintains a fibroblastic phenotype with co...

  9. DDR2 polymorphisms and mRNA expression in lung cancers of Japanese patients




    Discoidin domain receptor 2, DDR2, is a tyrosine kinase receptor for fibrillar collagen that is involved in postnatal development, tissue repair and primary and metastatic cancer progression. Recently, mutations in the DDR2 kinase gene were identified in squamous cell lung cancer from large-scale Sanger sequencing. The present study investigated the DDR2 gene mutations and mRNA expression in surgically treated non-small cell lung cancer (NSCLC) of squamous histology cases. The presence or abs...

  10. DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells. (United States)

    Olaso, E; Ikeda, K; Eng, F J; Xu, L; Wang, L H; Lin, H C; Friedman, S L


    Type I collagen provokes activation of hepatic stellate cells during liver injury through mechanisms that have been unclear. Here, we tested the role of the discoidin domain tyrosine kinase receptor 2 (DDR2), which signals in response to type I collagen, in this pathway. DDR2 mRNA and protein are induced in stellate cells activated by primary culture or in vivo during liver injury. The receptor becomes tyrosine phosphorylated in response to either endogenous or exogenous type I collagen, whereas its expression is downregulated during cellular quiescence induced by growth on Matrigel. We developed stellate cell lines stably overexpressing either wild-type DDR2, a constitutively active chimeric DDR2 receptor (Fc-DDR2), a truncated receptor expressing the extracellular domain, or a kinase-dead DDR2 Cells overexpressing DDR2 showed enhanced proliferation and invasion through Matrigel, activities that were directly related to increased expression of active matrix metalloproteinase 2 (MMP-2). These data show that DDR2 is induced during stellate cell activation and implicate the phosphorylated receptor as a mediator of MMP-2 release and growth stimulation in response to type I collagen. Moreover, type I collagen-dependent upregulation of DDR2 expression establishes a positive feedback loop in activated stellate cells, leading to further proliferation and enhanced invasive activity.

  11. A host deficiency of discoidin domain receptor 2 (DDR2) inhibits both tumour angiogenesis and metastasis. (United States)

    Zhang, Shuya; Bu, Xin; Zhao, Hu; Yu, Jiangtian; Wang, Yingmei; Li, Di; Zhu, Chuchao; Zhu, Tong; Ren, Tingting; Liu, Xinping; Yao, Libo; Su, Jin


    Discoidin domain receptor 2 (DDR2) is a unique receptor tyrosine kinase (RTK) that signals in response to collagen binding and is implicated in tumour malignant phenotypes such as invasion and metastasis. Although it has been reported that DDR2 expression is up-regulated in activated endothelial cells (ECs), functional studies are lacking. Herein, we found that enforced expression of DDR2 promoted proliferation, migration and tube formation of primary human umbilical vein endothelial cells (HUVECs). The results of immunohistochemical analysis showed a strikingly high level of DDR2 in human tumour ECs. Most significantly, we discovered that a host deficiency of DDR2 inhibits subcutaneous angiogenesis induced by either VEGF or tumour cells. In addition, the remaining tumour vessels in DDR2-deficient mice exhibit some normalized properties. These vascular phenotypes are accompanied by the up-regulation of anti-angiogenic genes and down-regulation of pro-angiogenic genes, as well as by alleviated tumour hypoxia. By use of a tail vein metastasis model of melanoma, we uncovered that loss of stromal DDR2 also suppresses tumour metastasis to the lung. Hence, our current data disclose a new mechanism by which DDR2 affects tumour progression, and may strengthen the feasibility of targeting DDR2 as an anticancer strategy.

  12. The intracellular juxtamembrane domain of discoidin domain receptor 2 (DDR2) is essential for receptor activation and DDR2-mediated cancer progression. (United States)

    Kim, Daehwan; Ko, Panseon; You, Eunae; Rhee, Sangmyung


    Discoidin domain receptors (DDRs) are unusual receptor tyrosine kinases (RTKs) that are activated by fibrillar collagens instead of soluble growth factors. DDRs play an important role in various cellular functions and disease processes, including malignant progression. Compared to other RTKs, DDRs have relatively long juxtamembrane domains, which are believed to contribute to receptor function. Despite this possibility, the function and mechanism of the juxtamembrane domain of DDRs have not yet been fully elucidated. In this study, we found that the cytoplasmic juxtamembrane 2 (JM2) region of DDR2 contributed to receptor dimerization, which is critical for receptor activation in response to collagen stimulation. A collagen-binding assay showed that JM2 was required for efficient binding of collagen to the discoidin (DS) domain. Immunohistochemical analysis of DDR2 expression using a tissue microarray demonstrated that DDR2 was overexpressed in several carcinoma tissues, including bladder, testis, lung, kidney, prostate and stomach. In H1299 cells, inhibition of DDR2 activity by overexpressing the juxtamembrane domain containing JM2 suppressed collagen-induced colony formation, cell proliferation and invasion via the inhibition of matrix metalloproteinase-2 and matrix metalloproteinase-9. Taken together, our results suggest that JM2-mediated dimerization is likely to be essential for DDR2 activation and cancer progression. Thus, inhibition of DDR2 function using a JM2-containing peptide might be a useful strategy for the treatment of DDR2-positive cancers.

  13. Transcriptional upregulation of DDR2 by ATF4 facilitates osteoblastic differentiation through p38 MAPK-mediated Runx2 activation. (United States)

    Lin, Kuan-Liang; Chou, Ching-Heng; Hsieh, Shu-Chen; Hwa, Su-Yang; Lee, Ming-Ta; Wang, Fung-Fang


    Deficiency of the collagen receptor discoidin domain receptor tyrosine kinase (DDR2) in mice and humans results in dwarfism and short limbs, of which the mechanism remains unknown. Here we report that DDR2 is a key regulator of osteoblast differentiation. DDR2 mRNA expression was increased at an early stage of induced osteoblast differentiation. In the subchondral bone of human osteoarthritic knee, DDR2 was detected in osteoblastic cells. In mouse embryos, DDR2 expression was found from E11 to E15, preceding osteocalcin (OCN) and coinciding with Runx2 expression. Activating transcription factor 4 (ATF4) enhanced DDR2 mRNA expression, and knockdown of ATF4 expression delayed DDR2 induction during osteoblast differentiation. A CCAAT/enhancer binding protein (C/EBP) binding site at -1150 bp in the DDR2 promoter was required for ATF4-mediated DDR2 activation. C/EBPβ bound to and cooperated with ATF4 in stimulating DDR2 transcription; accordingly, the ATF4 mutants deficient of C/EBPβ binding were incapable of transactivating DDR2. Overexpression of DDR2 increased osteoblast-specific gene expression. Conversely, knockdown of DDR2 suppressed osteogenic marker gene expression and matrix mineralization during the induced osteogenesis. The stimulation of p38 MAPK by DDR2 was required for DDR2-induced activation of Runx2 and OCN promoters. Together our findings uncover a pathway in which ATF4, by binding to C/EBPβ transcriptionally upregulates DDR2 expression, and DDR2, in turn, activates Runx2 through p38 MAPK to promote osteoblast differentiation.

  14. Mitochondrial dysfunction in DDR-related cancer predisposition syndromes. (United States)

    Lyakhovich, Alex; Graifer, Dmitry; Stefanovie, Barbora; Krejci, Lumir


    Given the key role of mitochondria in various cellular events, it is not surprising that mitochondrial dysfunction (MDF) is seen in many pathological conditions, in particular cancer. The mechanisms defining MDF are not clearly understood and may involve genetic defects, misbalance of reactive oxygen species (ROS), impaired autophagy (mitophagy), acquired mutations in mitochondrial or nuclear DNA and inability of cells to cope with the consequences. The importance of MDF arises from its detection in the syndromes with defective DNA damage response (DDR) and cancer predisposition. Here, we will focus on the dual role of these syndromes in cancer predisposition and MDF with specific emphasis on impaired autophagy.

  15. 容量与速度的对话 勤茂DDR2-700&宇瞻Low Profile内存

    Institute of Scientific and Technical Information of China (English)




  16. The Struggle after Combat. The role of NGOs in DDR processes: Afganistan Case Study

    NARCIS (Netherlands)

    Frerks, G.E.; Gompelman, G.; Laar, van de S.; Klem, B.


    Onderzoeksverslag met de vraag wat de rol van NGO's (non gouvermental organisations) in DDR processen (disarment, demobilisation and reintegration of ex-combatants)It has come to be well-recognised that effective DDR (Disarmant, Demobilisation and Reinregration of ex-combatants) is crucial for build

  17. Stiefkind der Staatengemeinschaft : Die Anerkennungspolitik der DDR in Westeuropa 1949 - 1973

    NARCIS (Netherlands)

    Horstmeier, Carel


    Stiefkind van de internationale gemeenschap. De erkenningspolitiek van de DDR in West-Europa 1949-1973De Duitse Democratische Republiek (DDR) was vanaf haar oprichting in 1949 internationaal geïsoleerd. Alleen de 11 andere communistische staten wilden haar diplomatiek erkennen. Dit proefschrift onde

  18. 神龙初现DDR Ⅱ 800恐怖测试

    Institute of Scientific and Technical Information of China (English)


    Intel的i9xx系列目前正在迅速渗透市场,尽管去年DDR Ⅱ的表现不尽如人意,但DDR Ⅱ内存的兴起是必然的趋势,毕竟从技术上而言DDR Ⅱ 4bit预读取等技术优势是DDR无法比拟的。之所以一些用户感到DDR Ⅱ对系统性能提升不大,主要是由于支持DDR Ⅱ的主板以及CPU限制了DDR Ⅱ更好地发挥性能。如果DDR Ⅱ能放低姿态,把价格降到与DDR接近的水平,会有多少玩家倒向DDR Ⅱ呢?而这也是今年内存市场的趋势。

  19. Regulation of collagen fibrillogenesis by cell-surface expression of kinase dead DDR2. (United States)

    Blissett, Angela R; Garbellini, Derek; Calomeni, Edward P; Mihai, Cosmin; Elton, Terry S; Agarwal, Gunjan


    The assembly of collagen fibers, the major component of the extracellular matrix (ECM), governs a variety of physiological processes. Collagen fibrillogenesis is a tightly controlled process in which several factors, including collagen binding proteins, have a crucial role. Discoidin domain receptors (DDR1 and DDR2) are receptor tyrosine kinases that bind to and are phosphorylated upon collagen binding. The phosphorylation of DDRs is known to activate matrix metalloproteases, which in turn cleave the ECM. In our earlier studies, we established a novel mechanism of collagen regulation by DDRs; that is, the extracellular domain (ECD) of DDR2, when used as a purified, soluble protein, inhibits collagen fibrillogenesis in-vitro. To extend this novel observation, the current study investigates how the DDR2-ECD, when expressed as a membrane-anchored, cell-surface protein, affects collagen fibrillogenesis by cells. We generated a mouse osteoblast cell line that stably expresses a kinase-deficient form of DDR2, termed DDR2/-KD, on its cell surface. Transmission electron microscopy, fluorescence microscopy, and hydroxyproline assays demonstrated that the expression of DDR2/-KD reduced the rate and abundance of collagen deposition and induced significant morphological changes in the resulting fibers. Taken together, our observations extend the functional roles that DDR2 and possibly other membrane-anchored, collagen-binding proteins can play in the regulation of cell adhesion, migration, proliferation and in the remodeling of the extracellular matrix.

  20. NSCLC Driven by DDR2 Mutation Is Sensitive to Dasatinib and JQ1 Combination Therapy. (United States)

    Xu, Chunxiao; Buczkowski, Kevin A; Zhang, Yanxi; Asahina, Hajime; Beauchamp, Ellen M; Terai, Hideki; Li, Yvonne Y; Meyerson, Matthew; Wong, Kwok-Kin; Hammerman, Peter S


    Genetically engineered mouse models of lung cancer have demonstrated an important role in understanding the function of novel lung cancer oncogenes and tumor-suppressor genes identified in genomic studies of human lung cancer. Furthermore, these models are important platforms for preclinical therapeutic studies. Here, we generated a mouse model of lung adenocarcinoma driven by mutation of the discoidin domain receptor 2 (DDR2) gene combined with loss of TP53. DDR2(L63V);TP53(L/L) mice developed poorly differentiated lung adenocarcinomas in all transgenic animals analyzed with a latency of 40 to 50 weeks and a median survival of 67.5 weeks. Mice expressing wild-type DDR2 with combined TP53 loss did not form lung cancers. DDR2(L63V);TP53(L/L) tumors displayed robust expression of DDR2 and immunohistochemical markers of lung adenocarcinoma comparable with previously generated models, though also displayed concomitant expression of the squamous cell markers p63 and SOX2. Tumor-derived cell lines were not solely DDR2 dependent and displayed upregulation of and partial dependence on MYCN. Combined treatment with the multitargeted DDR2 inhibitor dasatinib and BET inhibitor JQ1 inhibited tumor growth in vitro and in vivo. Together, these results suggest that DDR2 mutation can drive lung cancer initiation in vivo and provide a novel mouse model for lung cancer therapeutics studies.

  1. The collagen receptor DDR2 is expressed during early cardiac development. (United States)

    Goldsmith, Edie C; Zhang, Xiadong; Watson, James; Hastings, Josh; Potts, Jay D


    Discoidin Domain Receptor 2 (DDR2) is a receptor tyrosine kinase which has been shown to regulate cell migration upon binding its ligand, collagen. Expression studies determined that DDR2 mRNA and protein are present in the atrioventricular canal during epithelial-mesenchymal transformation (EMT) and the receptor is expressed in both activated endothelial and migrating mesenchymal cells in vivo.

  2. NER and DDR: classical music with new instruments. (United States)

    Sertic, Sarah; Pizzi, Sara; Lazzaro, Federico; Plevani, Paolo; Muzi-Falconi, Marco


    Genomic insults by endogenous or exogenous sources activate the DNA damage response (DDR). After the recognition of damaged DNA by specific factors, repair mechanisms process the lesions, and a surveillance mechanism, known as DNA damage checkpoint, is triggered by single-stranded (ss) DNA covered by RPA. UV light induces DNA lesions, mainly 6,4 photoproducts (6-4PP) and cyclobutane pyrimidine dimers (CPD), which are removed by nucleotide excision repair (NER). Recent reports shed light onto the mechanism connecting NER and DDR after UV irradiation. How does UV-induced DNA damage activate checkpoint kinases? How is ssDNA generated at UV lesions? In yeast, UV lesions persisting during S phase represent a block for the advancing of replication forks, which temporarily stop and then reinitiate downstream of the damage, leaving a ssDNA region containing the lesion. Nonreplicating yeast and human cells with defects in NER are not able to properly activate the checkpoint cascade, indicating that processing of UV lesions is a prerequisite for checkpoint activation. This pathway also requires the function of exonuclease 1, which acts on NER intermediates generating long tracts of ssDNA. Here, we review the connections between NER processing of UV-induced lesions and checkpoint activation, discussing the role of recently identified players in this mechanism.

  3. Nrp1, a Neuronal Regulator, Enhances DDR2-ERK-Runx2 Cascade in Osteoblast Differentiation via Suppression of DDR2 Degradation


    Yan Zhang; Jin Su; Yue Teng; Jian Zhang; Jiang Wang; Kun Li; Libo Yao; Xu Li


    Background: Osteoblastogenesis is under delicate control by multiple factors and hormones. Recent reports indicated the involvement of immunological and neuronal regulators. However, the role of neuropilin 1 (Nrp1) in osteoblastogenesis remains obscure. Methods: Real-time PCR was carried out to detect the mRNA of osteoblastic markers, Nrp1, and discoidin domain receptor 2 (DDR2). Immunoblot was performed to test the protein of Nrp1 and DDR2. Osteogenic differentiation was evaluated by mRNA an...

  4. 超胜白金DDR2内存条

    Institute of Scientific and Technical Information of China (English)



  5. 硬件联盟讨论——DDR2的到来

    Institute of Scientific and Technical Information of China (English)



  6. 退一进二——DDR2选购正当时

    Institute of Scientific and Technical Information of China (English)




  7. Discoidin domain receptor 2 (DDR2) regulates body size and fat metabolism in mice. (United States)

    Kawai, Ikuma; Matsumura, Hirokazu; Fujii, Wataru; Naito, Kunihiko; Kusakabe, Ken; Kiso, Yasuo; Kano, Kiyoshi


    Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase that is activated by fibrillar collagens, which act as its endogenous ligand. DDR2 regulates cell proliferation, cell adhesion, migration, extracellular matrix remodeling and reproductive functions. Both DDR2 null allele mice and mice with a recessive, loss-of-function allele for Ddr2 exhibit dwarfing and a reduction in body weight. However, the detailed mechanisms by which DDR2 exerts its positive systemic regulation of whole body size, local skeletal size and fat tissue volume remain to be clarified. To investigate the systemic role of DDR2 in body size regulation, we produced transgenic mice in which the DDR2 protein is overexpressed, then screened the transgenic mice for abnormalities using systematic mouse abnormality screening. The modified-SHIPRA screen revealed that only the parameter of body size was significantly different among the genotypes. We also discovered that the body length was significantly increased, while the body weight was significantly decreased in transgenic mice compared to their littermate controls. We also found that the epididymal fat pads were significantly decreased in transgenic mice compared to normal littermate mice, which may have been the cause of the leptin decrement in the transgenic mice. The new insight that DDR2 might promote metabolism in adipocyte cells is very interesting, but more experiments will be needed to elucidate the direct relation between DDR2 and adipose-derived hormones. Taken together, our data demonstrated that DDR2 might play a systemic role in the regulation of body size thorough skeletal formation and fat metabolism.

  8. The D2 period of collagen II contains a specific binding site for the human discoidin domain receptor, DDR2. (United States)

    Leitinger, Birgit; Steplewski, Andrzej; Fertala, Andrzej


    The human discoidin domain receptors (DDRs), DDR1 and DDR2, are expressed widely and, uniquely among receptor tyrosine kinases, activated by the extracellular matrix protein collagen. This activation is due to a direct interaction of collagen with the DDR discoidin domain. Here, we localised a specific DDR2 binding site on the triple-helical region of collagen II. Collagen II was found to be a much better ligand for DDR2 than for DDR1. As expected, DDR2 binding to collagen II was dependent on triple-helical collagen and was mediated by the DDR2 discoidin domain. Collagen II served as a potent stimulator of DDR2 autophosphorylation, the first step in transmembrane signalling. To map the DDR2 binding site(s) on collagen II, we used recombinant collagen II variants with specific deletions of one of the four repeating D periods. We found that the D2 period of collagen II was essential for DDR2 binding and receptor autophosphorylation, whereas the D3 and D4 periods were dispensable. The DDR2 binding site on collagen II was further defined by recombinant collagen II-like proteins consisting predominantly of tandem repeats of the D2 or D4 period. The D2 construct, but not the D4 construct, mediated DDR2 binding and receptor autophosphorylation, demonstrating that the D2 period of collagen II harbours a specific DDR2 recognition site. The discovery of a site-specific interaction of DDR2 with collagen II gives novel insight into the nature of the interaction of collagen II with matrix receptors.

  9. 高标准是性能的保证——威刚A-DATA DDR2 800

    Institute of Scientific and Technical Information of China (English)



    近日PC Magazine实验室收到一款威刚送测的A-DATA DDR2 800内存,相对于早期的双通道DDR2 533内存,DDR2 800的传输速率可以达到12.8GB/s.带宽性能比之前者提升近40%。可以说只有DDR2 800才能真正将DDR2内存的优势充分体现出采。

  10. DDR-mediated crosstalk between DNA-damaged cells and their microenvironment. (United States)

    Malaquin, Nicolas; Carrier-Leclerc, Audrey; Dessureault, Mireille; Rodier, Francis


    The DNA damage response (DDR) is an evolutionarily conserved signaling cascade that senses and responds to double-strand DNA breaks by organizing downstream cellular events, ranging from appropriate DNA repair to cell cycle checkpoints. In higher organisms, the DDR prevents neoplastic transformation by directly protecting the information contained in the genome and by regulating cell fate decisions, like apoptosis and senescence, to ensure the removal of severely damaged cells. In addition to these well-studied cell-autonomous effects, emerging evidence now shows that the DDR signaling cascade can also function in a paracrine manner, thus influencing the biology of the surrounding cellular microenvironment. In this context, the DDR plays an emerging role in shaping the damaged tumor microenvironment through the regulation of tissue repair and local immune responses, thereby providing a promising avenue for novel therapeutic interventions. Additionally, while DDR-mediated extracellular signals can convey information to surrounding, undamaged cells, they can also feedback onto DNA-damaged cells to reinforce selected signaling pathways. Overall, these extracellular DDR signals can be subdivided into two time-specific waves: a rapid bystander effect occurring within a few hours of DNA damage; and a late, delayed, senescence-associated secretory phenotype generally requiring multiple days to establish. Here, we highlight and discuss examples of rapid and late DDR-mediated extracellular alarm signals.

  11. Expression of Discoidin Domain Receptor 2 (DDR2) in the Developing Heart (United States)

    Morales, Mary O.; Price, Robert L.; Goldsmith, Edie C.


    Interactions between cells and the surrounding extracellular matrix are important for a number of developmental events. In the heart, cardiac fibroblasts produce the majority of extracellular matrix proteins, particularly collagen types I and III. Cells originating from the proepicardial organ migrate over the surface of the heart, invade the underlying myocardium and ultimately give rise to smooth muscle cells, fibroblasts, and coronary endothelium. Although integrin expression in the developing heart has been well characterized, the expression of Discoidin Domain Receptor 2 (DDR2) remains to be defined. Using confocal microscopy, the expression of DDR2 was examined at several points during cardiac development. Initially, DDR2 expression was detected on the epicardial surface of the heart and on endothelial and mesenchymal cells within the cardiac cushions. As development progressed, DDR2 expression increased at localized regions in the apex and atrioventricular sulcus, although this expression decreased from epicardial to endocardial surface. Eventually, DDR2 expression spanned the myocardial free wall and was detected within the septum. Not until postnatal development was DDR2 expression detected uniformly throughout the myocardium and this distribution was maintained in the adult heart. In summary, the data presented demonstrate that the distribution of DDR2-positive cells changes within the heart during development.

  12. Fusion expression of DDR2 extracellular domain in insect cells and its purification and function characterization. (United States)

    Zhang, Wei; Ding, Tianbing; Zhang, Jian; Su, Jin; Yu, Jiangtian; Li, Jipeng; Li, Fuyang; Wang, Chunmei; Liu, Nannan; Liu, Xinping; Ma, Wenyu; Yao, Libo


    Discoidin domain receptor 2 (DDR2) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, a ligand for DDR2, up-regulates matrix metalloproteinase 1 (MMP-1) and MMP-2 expression in extracellular matrix (ECM). To investigate the role of DDR2 in cartilage destruction in rheumatoid arthritis (RA), we expressed the extracellular domain (ECD) of DDR2 (without signal peptide and transmembrane domain, designated DR) in insect cells, purified and characterized DR, hoping to use it as a specific antagonist of DDR2. By using Bac-To-Bac Expression System with a His tag, we successfully obtained the recombinant bacularvirus containing DDR2 ECD, purified it and characterized its function. The soluble fraction of DR was about 12% of the total fused protein. After chromatographic purification, DR with 92% purity was obtained. Competitive inhibition assay demonstrated that DR blocked the binding between DDR2 and natural DDR2 receptors on NIH3T3 and synovial cells. Results of RT-PCR, Western blotting, and gelatinase zymography showed that DR was capable of inhibiting MMP-1 and MMP-2 secretion from NIH3T3 and RA synoviocytes stimulated by collagen II. For MMP-1, inhibition was displayed at the levels of mRNA and protein, whereas for MMP-2 it was at the level of protein. These findings suggested that the expressed DR inhibited the activity of natural DDR2 and relevant MMP-1 and MMP-2 expression in RA synoviocytes and NIH3T3 cells provoked by collagen II.

  13. DDR2 800我们真的不需要吗? 威刚红色威龙DDR2 800评测

    Institute of Scientific and Technical Information of China (English)


    DDR2 800已经推出一年左右了,但由于价格过高,以及大家对于主板无法直接支持高频率内存的顾虑,DDR2 800的产品大家很少会想去触及,DDR2 667更多的被认为是目前家用内存的最高频率。不过随着技术的发展,现在已经有不少主板可以直接支持DDR2 800内存,即便是老型号主板我们也可以通过调整异步频率和CL值来体现其的实力,今天我们拿了威刚的红色威龙DDR2 800,如果您也曾对DD2R2 800的实用性有所怀疑,不妨我们一同来看看它在实际使用中的表现。

  14. Weyl compatible tensors

    CERN Document Server

    Mantica, Carlo A


    The algebraic condition of Riemann compatibility for symmetric tensors generalizes the differential Codazzi condition, but preserves much of the geometric content. The compatibility condition can be extended to other curvature tensors. This paper is about Weyl compatible tensors and vectors. In particular it is shown that the existence of a Weyl compatible vector implies the Weyl tensor to be algebraically special, and it is a necessary and sufficient condition for the magnetic part to vanish. Some theorems (Derdzinski and Shen, Hall) are extended to the broader hypothesis of Weyl or Riemann compatibility. Weyl compatibility includes conditions that were investigated in the literature of general relativity (as McIntosh et al.). Hypersurfaces of pseudo Euclidean spaces provide a simple example of Weyl compatible Ricci tensor.

  15. Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1. (United States)

    Xu, Huifang; Raynal, Nicolas; Stathopoulos, Stavros; Myllyharju, Johanna; Farndale, Richard W; Leitinger, Birgit


    The discoidin domain receptors, DDR1 and DDR2 are cell surface receptor tyrosine kinases that are activated by triple-helical collagen. While normal DDR signalling regulates fundamental cellular processes, aberrant DDR signalling is associated with several human diseases. We previously identified GVMGFO (O is hydroxyproline) as a major DDR2 binding site in collagens I-III, and located two additional DDR2 binding sites in collagen II. Here we extend these studies to the homologous DDR1 and the identification of DDR binding sites on collagen III. Using sets of overlapping triple-helical peptides, the Collagen II and Collagen III Toolkits, we located several DDR2 binding sites on both collagens. The interaction of DDR1 with Toolkit peptides was more restricted, with DDR1 mainly binding to peptides containing the GVMGFO motif. Triple-helical peptides containing the GVMGFO motif induced DDR1 transmembrane signalling, and DDR1 binding and receptor activation occurred with the same amino acid requirements as previously defined for DDR2. While both DDRs exhibit the same specificity for binding the GVMGFO motif, which is present only in fibrillar collagens, the two receptors display distinct preferences for certain non-fibrillar collagens, with the basement membrane collagen IV being exclusively recognised by DDR1. Based on our recent crystal structure of a DDR2-collagen complex, we designed mutations to identify the molecular determinants for DDR1 binding to collagen IV. By replacing five amino acids in DDR2 with the corresponding DDR1 residues we were able to create a DDR2 construct that could function as a collagen IV receptor.

  16. DDR and the Internal Organization of Non-State Armed Groups

    Directory of Open Access Journals (Sweden)

    Brian McQuinn


    Full Text Available This paper argues that demobilization, disarmament and reintegration (DDR trajectories of non-state armed groups are shaped by a group’s internal organization. Extensive research by political scientists has demonstrated a correlation between internal features of armed groups and their behaviour (e.g. extent of violence used against local communities. I extend this analysis to DDR outcomes by illustrating how two features of an armed group’s internal organization – command profile and financing architecture – influence post-conflict DDR trajectories. To substantiate the theory, four case studies from Colombia, Nepal and Libya are reviewed. The article concludes with the limitations and opportunities of this approach, including the potential of predicting DDR challenges.

  17. Die Entwicklung der Arbeitsgemeinschaft "Radiochemische Analysenmethoden" im Fachverband Analytik der Chemischen Gesellschaft der DDR


    Niese, Siegfried


    Es wird die Geschichte der Arbeitsgemeinschaft Radiochemische Analysenmethoden in der Chemischen Gesellschaft der DDR beschrieben. The History of the working-pool Radioanalytical Chemistry of the Chemical Society of the GDR is described.

  18. Radiation Performance of 1 Gbit DDR SDRAMs Fabricated in the 90 nm CMOS Technology Node (United States)

    Ladbury, Raymond L.; Gorelick, Jerry L.; Berg, M. D.; Kim, H.; LaBel, K.; Friendlich, M.; Koga, R.; George, J.; Crain, S.; Yu, P.; Reed, R. A.


    We present Single Event Effect (SEE) and Total Ionizing Dose (TID) data for 1 Gbit DDR SDRAMs (90 nm CMOS technology) as well as comparing this data with earlier technology nodes from the same manufacturer.

  19. A trustworthy key generation prototype based on DDR3 PUF for wireless sensor networks. (United States)

    Liu, Wenchao; Zhang, Zhenhua; Li, Miaoxin; Liu, Zhenglin


    Secret key leakage in wireless sensor networks (WSNs) is a high security risk especially when sensor nodes are deployed in hostile environment and physically accessible to attackers. With nowadays semi/fully-invasive attack techniques attackers can directly derive the cryptographic key from non-volatile memory (NVM) storage. Physically Unclonable Function (PUF) is a promising technology to resist node capture attacks, and it also provides a low cost and tamper-resistant key provisioning solution. In this paper, we designed a PUF based on double-data-rate SDRAM Type 3 (DDR3) memory by exploring its memory decay characteristics. We also described a prototype of 128-bit key generation based on DDR3 PUF with integrated fuzzy extractor. Due to the wide adoption of DDR3 memory in WSN, our proposed DDR3 PUF technology with high security levels and no required hardware changes is suitable for a wide range of WSN applications.

  20. A Trustworthy Key Generation Prototype Based on DDR3 PUF for Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Wenchao Liu


    Full Text Available Secret key leakage in wireless sensor networks (WSNs is a high security risk especially when sensor nodes are deployed in hostile environment and physically accessible to attackers. With nowadays semi/fully-invasive attack techniques attackers can directly derive the cryptographic key from non-volatile memory (NVM storage. Physically Unclonable Function (PUF is a promising technology to resist node capture attacks, and it also provides a low cost and tamper-resistant key provisioning solution. In this paper, we designed a PUF based on double-data-rate SDRAM Type 3 (DDR3 memory by exploring its memory decay characteristics. We also described a prototype of 128-bit key generation based on DDR3 PUF with integrated fuzzy extractor. Due to the wide adoption of DDR3 memory in WSN, our proposed DDR3 PUF technology with high security levels and no required hardware changes is suitable for a wide range of WSN applications.

  1. 频率提升——KingMax DDR2-800

    Institute of Scientific and Technical Information of China (English)



    Pentlum D处理器与Intel 945/955芯片组的问世,带动7DDR2内存频率的发展——从DDR2—533过渡到DDR2—667。实际上.内存频率的发展一直领先于主板芯片组的规格.在Intel 945系列芯片组间世之前,DDR2—667内存就已经出现,只是因。为缺少平台的支持而无法得到推广。

  2. 狂飙1GHz PNY DDR2 1066内存

    Institute of Scientific and Technical Information of China (English)



    在目前的产品支持的实际测试中,最为实用的内存仍然是DDR2 667和DDR2 800。但是更高速的处理器的多核产品对内存带宽的要求快速增长,更高速的DDR2内存规格已经成为必然选择,而各大内存厂商也纷纷推出了DDR2 1066规格内存,其中也包括进入内地市场不久的PNY品牌内存。

  3. 2G诱惑 四款DDR2-800全面测试

    Institute of Scientific and Technical Information of China (English)



  4. 一种基于AHB总线的Nor Flash控制器设计%Design of a Nor Flash controller based on AHB bus

    Institute of Scientific and Technical Information of China (English)

    戴骏; 刘佩林


    基于AHB总线接口,设计了一种Nor Flash控制器,与传统Nor Flash控制器相比,本设计适用于对Nor Flash快速读取,支持代码保护机制和ECC容错,满足高速率读取,高可靠性要求.首先介绍了控制器的整体架构,然后描述各子模块的实现方式,同时搭建仿真平台,使用simvision仿真套件,基于Cortex m0内核和PF64 AK32 E型Nor Flash行为级模型实现软硬件协同仿真.仿真结果满足时序要求,快速读取模式将读取速率提升25%.%This paper designs a Nor Flash controller based on AHB bus interface. Compared with the traditional Nor Flash controller, the design is suitable for fast reading, code protection mechanism and ECC fault tolerance, which meets requirements of high rate of reading and high reliability. Firstly, the paper introduces the overall architecture of the Nor Flash controller, then describes the implementation of each submodule. Finally it builds the simulation platform with simvision software to realize the software/hardware co-simulation. Plenty of simulations show that the design meet both the functional and timing requirements. The reading rate of fast reading mode is 25% higher than if of normal mode.

  5. United Nations-Led Disarmament, Demobilization and Reintegration (DDR) in the Eastern Democratic Republic of Congo (United States)


    the disarmament, demobilization, repatriation, reintegration and resettlement (DDRRR) of foreign armed groups. Although there has been some success ... success of the reintegration of ex-combatants, and cast doubt on the viability of DDR as a tool for achieving peace in the eastern DRC. Scholars and...Broadcasting, 2009). 10 Shane R Doolan, “Coercive Disarmament Demobilization and Reintegration (DDR) can it be Successful ?” (MA thesis, Naval Postgraduate

  6. A kind of DDR2 Interface Design In Motherboard%DDR2在一种电脑主板上的接口设计

    Institute of Scientific and Technical Information of China (English)

    贺良华; 李琴


    根据DDR2的技术规范,在介绍了DDR2 SDRAM的基本特征、工作原理的基础上,分别针对主板上内存部分与北桥、时钟发生器以及电源部分的连接做出了相应的研究,并使用Cadence,Allegro工具软件对接口电路进行了优化设计.

  7. Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells. (United States)

    Song, Jingyuan; Chen, Xiao; Bai, Jin; Liu, Qinghua; Li, Hui; Xie, Jianwan; Jing, Hui; Zheng, Junnian


    Discoidin domain receptor I (DDR1) is confirmed as a receptor tyrosine kinase (RTK), which plays a consequential role in a variety of cancers. Nevertheless, the influence of DDR1 expression and development in renal clear cell carcinoma (RCCC) are still not well corroborated. In our research, we firstly discovered that the expression level of DDR1 was remarkable related to TNM stage (p = 0.032), depth of tumor invasion (p = 0.047), and lymph node metastasis (p = 0.034) in 119 RCCC tissue samples using tissue microarray. The function of DDR1 was then evaluated in vitro using collagen I and DDR1 small interfering RNA (siRNA) to regulate the expression of DDR1 in OS-RC-2 and ACHN renal cancer cells (RCC). DDR1 expression correlated with increased RCC cell migration, invasion, and angiogenesis. Further study revealed that high expression of DDR1 can result in epithelial to mesenchymal transition (EMT) activation. Western blot assay showed that the N-cadherin protein and vimentin were induced while E-cadherin was reduced after DDR1 over expression. Our results suggest that DDR1 is both a prognostic marker for RCCC and a potential functional target for therapy.

  8. Evaluation of discoidin domain receptor-2 (DDR2) expression level in normal, benign, and malignant human prostate tissues. (United States)

    Azemikhah, Mitra; Ashtiani, Hamidreza Ahmadi; Aghaei, Mahmoud; Rastegar, Hosein


    Discoidin domain receptor (DDR) is a new member of the receptor tyrosine kinase family. There are two isoforms of discoidin domain receptor (DDR), DDR1 and DDR2. These receptors play a major role in the adhesion, motility and cell proliferation. Due to the important role of DDR2 in the development of tumor extension, this receptor is pivotal in the field of carcinogenesis. The aim of this study was to investigate the mRNA and protein expression of DDR2, in the malignant, benign prostatic hyperplasia (BPH) and normal tissues of patients with prostate cancer. In this study the gene and protein expression of DDR2 in adjacent normal (n=40), BPH (n=40), and malignant (n=40) prostate tissue were measured using real-time PCR and Western blotting. Then, the correlation of DDR2 gene and protein expression with prognostic factors such as age, tumor grade, tumor stage, lymph node involvement, and serum prostate-specific antigen (PSA) concentration were evaluated. The relative mRNA and protein expression level of DDR2 in malignant and benign prostate tissue was significantly higher than those of adjacent normal tissues (PDDR2 mRNA and protein expression with prognostic factors such as tumor grade, stage, lymph node involvement, and serum PSA concentration. However, significant correlation with age was not observed. These findings suggest that DDR2 is a cancer-related gene associated with the aggressive progression of prostate cancer patients.

  9. Overexpression of DDR2 contributes to cell invasion and migration in head and neck squamous cell carcinoma. (United States)

    Xu, Jinke; Lu, Wei; Zhang, Senlin; Zhu, Chuchao; Ren, Tingting; Zhu, Tong; Zhao, Hu; Liu, Yanpu; Su, Jin


    Background Discoidin domain receptor 2 (DDR2) is a unique receptor tyrosine kinase (RTK) that is activated by fibrillar collagens. Although DDR2 contributes to the metastasis of some tumors, its role in head and neck squamous cell carcinoma (HNSCC) remains unknown. The aim of this study was to investigate the expression level, clinical and pathological significance, and biologic function of DDR2 in HNSCC. Methods Real-time quantitative PCR, western blot, and immunohistochemical staining were employed to assess the expression levels of DDR2 in HNSCC specimens. Adenovirus-mediated overexpression of DDR2 was used to evaluate its consequences on cell proliferation, invasion, migration, and the process of hypoxia-induced epithelial-mesenchymal transition (EMT). Then nude mouse xenograft and tail vein metastasis models were utilized to validate the in vitro results. Results DDR2 was highly expressed in high grade HNSCC tissues and lowly expressed in low grade HNSCC tissues, but absent or rarely expressed in cancer-associated normal tissues. Both the frequency and expression intensity of DDR2 were significantly associated with tumor pathologic stage and lymph node metastasis. In vitro, DDR2 overexpression in HNSCC cells failed to alter cell proliferation but markedly accelerates cell invasion and migration as well as hypoxia-induced EMT. In vivo, elevated expression of DDR2 speeds up the metastasis of HNSCC cells to the lung. Conclusion DDR2 plays an important role in HNSCC metastasis, and might be a promising target for future therapies in this type of cancer.

  10. The anti-angiogenic role of discoidin domain receptor 2 (DDR2) in laser-induced choroidal neovascularization. (United States)

    Zhu, Tong; Zhu, Jie; Bu, Xin; Zhao, Hu; Zhang, Shuya; Chang, Yuan; Li, Rong; Yao, Libo; Wang, Yusheng; Su, Jin


    Choroidal neovascularization (CNV), an aberrant growth of blood vessels in the choroid layer of the eye, is a major cause of vision loss. In view of our recent finding that discoidin domain receptor 2 (DDR2), a collagen-binding receptor tyrosine kinase, is involved in control of vascular endothelial activity and tumor angiogenesis, the present study aims to investigate whether and how DDR2 affects the pathogenesis of CNV. We initially found that a spontaneous DDR2 mutant mouse colony (slie) exhibited enhanced amplitude of laser-induced CNV. The inhibitory role of DDR2 in CNV development was further confirmed by experiments through intravitreous injection of DDR2 small interference RNA (siRNA) or DDR2-expressing adenovirus. Quantitative real-time polymerase chain reaction (qPCR) and immunoblot analysis showed that DDR2 regulates the expression of several major pro-angiogenic factors in the laser-injured choroid as well as in retinal pigment epithelium (RPE) cells. In addition, it was demonstrated that the CNV-induced increases in the phosphorylation levels of Akt and mTOR were affected by the upregulation or downregulation of DDR2. Thus, the data from this study for the first time revealed that DDR2 negatively regulates the development of experimental CNV in vivo, which may provide a novel target for preventing human pathological ocular neovascularization. Key messages: DDR2 does not affect retinal development. DDR2 inhibits laser-induced CNV. DDR2 regulates angiogenic factor expression in CNV lesion as well as in RPE cells. DDR2 is involved in modulation of CNV-induced activation of PI3K pathway.

  11. Infiniband Performance Comparisons of SDR, DDR and Infinipath

    Energy Technology Data Exchange (ETDEWEB)

    Minich, M


    This technical report will be comparing the performance between the most common infiniband-related technologies currently available. Included will be TCP-based, MPI-based and low-level performance tests to see what performance can be expected from Mellanox's SDR and DDR as well as PathScale's Infinipath. Also, we will be performing comparisons of the Infinipath on both OpenIB as well as PathScale's ipath stack. Infiniband promises to bring high performance interconnects for I/O (filesystem and networking) to a new cost performance level. Thus, LLNL has been evaluating Infiniband for use as a cluster interconnect. Various issues impact the decision of which interconnect to use in a cluster. This technical report will be looking more closely at the actual performance of the major infiniband technologies present today. Performance testing will focus on latency, and bandwidth (both uni and bi-directional) using both TCP and MPI. In addition, we will be looking at an even lower-level (removing most of the upper-level protocols) and seeing what the connection can really do if the TCP or MPI layers were perfectly written.

  12. Building Reused eVC Verification Based on AHB Bus%基于AHB总线接口的可重用性验证环境的实现

    Institute of Scientific and Technical Information of China (English)

    文良; 靳荣利; 吴龙胜; 刘佑宝


    文中提出了一种基于AHB总线接口的可重用性验证环境的实现方法.该方法是基于Verisity的eRM(eReused Methodology),通过增加配置的环境变量和eVC文件,并利用脚本自动化生成验证的基本框架,在验证不同的设计时只需根据实际协议扩展该基本验证环境框架即可.实现了各种基于AHB总线接口的验证环境的可重用性,提高了验证效率.%This paper is going to put forward a reused method basing on the AHB bus. This method is based on the eRM(e Reuse Methodology) of Verisity. By increasing configurable environment variables in each of eVC files, and then making use of the basic architecture of SOC automatically generated by the script languages, when you verify different design protocol, only need to extend the basis of the verification environment architecture. So this method will gain the reused verification of every design that is based on AHB bus interface and improve the efficiency of verification highly.

  13. The Screening of Interacting Proteins of DDR2 in RA FLSs%类风湿性关节炎滑膜细胞中DDR2相互作用蛋白的筛选

    Institute of Scientific and Technical Information of China (English)

    赵薇; 董晓薇; 舒震; 徐玉金; 张伟


    目的 筛选盘状结构域受体(discoidin domain receptors 2,DDR2)的相互作用蛋白.方法 原代培养类风湿性关节炎(rheumatoid arthritis,RA)成纤维样滑膜细胞(fibroblast-like synoviocytes,FLSs).用人DDR2过表达腺病毒(Ad5-DDR2)感染FLSs,上调DDR2的表达.采用Ⅱ型胶原诱导的方法活化FLSs细胞膜上的DDR2;提取细胞总蛋白,通过小鼠来源的DDR2抗体免疫沉淀FLSs中的DDR2蛋白复合物;双向电泳分离抗原抗体复合物,质谱分析确认DDR2活化前后的差异蛋白.结果 Ad5-DDR2感染RA FLSs后,Western-blot结果显示细胞中DDR2表达水平显著上调.双向电泳分离DDR2免疫沉淀复合物,考马斯亮蓝染色显示胶原刺激前后,DDR2免疫复合物存在7个差异蛋白点.质谱分析及生物信息学分析显示,DDR2相互作用蛋白主要包括波形蛋白(vimentin)、膜脂联蛋白A2(Annexin A2)、免疫球蛋白和肌动蛋白等.结论 筛选获得了两个可能与RA病程相关的DDR2相互作用蛋白——波形蛋白和膜脂联蛋白2,为DDR2-MMPs通路作用机制的阐明奠定了基础.

  14. DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer. (United States)

    Sears, Catherine R; Cooney, Sean A; Chin-Sinex, Helen; Mendonca, Marc S; Turchi, John J


    Non-small cell lung cancers (NSCLC) are commonly treated with a platinum-based chemotherapy such as cisplatin (CDDP) in combination with ionizing radiation (IR). Although clinical trials have demonstrated that the combination of CDDP and IR appear to be synergistic in terms of therapeutic efficacy, the mechanism of synergism remains largely uncharacterized. We investigated the role of the DNA damage response (DDR) in CDDP radiosensitization using two NSCLC cell lines. Using clonogenic survival assays, we determined that the cooperative cytotoxicity of CDDP and IR treatment is sequence dependent, requiring administration of CDDP prior to IR (CDDP-IR). We identified and interrogated the unique time and agent-dependent activation of the DDR in NSCLC cells treated with cisplatin-IR combination therapy. Compared to treatment with CDDP or IR alone, CDDP-IR combination treatment led to persistence of γH2Ax foci, a marker of DNA double-strand breaks (DSB), for up to 24h after treatment. Interestingly, pharmacologic inhibition of DDR sensor kinases revealed the persistence of γ-H2Ax foci in CDDP-IR treated cells is independent of kinase activation. Taken together, our data suggest that delayed repair of DSBs in NSCLC cells treated with CDDP-IR contributes to CDDP radiosensitization and that alterations of the DDR pathways by inhibition of specific DDR kinases can augment CDDP-IR cytotoxicity by a complementary mechanism.

  15. Emergence and evolutionary analysis of the human DDR network: implications in comparative genomics and downstream analyses. (United States)

    Arcas, Aida; Fernández-Capetillo, Oscar; Cases, Ildefonso; Rojas, Ana M


    The DNA damage response (DDR) is a crucial signaling network that preserves the integrity of the genome. This network is an ensemble of distinct but often overlapping subnetworks, where different components fulfill distinct functions in precise spatial and temporal scenarios. To understand how these elements have been assembled together in humans, we performed comparative genomic analyses in 47 selected species to trace back their emergence using systematic phylogenetic analyses and estimated gene ages. The emergence of the contribution of posttranslational modifications to the complex regulation of DDR was also investigated. This is the first time a systematic analysis has focused on the evolution of DDR subnetworks as a whole. Our results indicate that a DDR core, mostly constructed around metabolic activities, appeared soon after the emergence of eukaryotes, and that additional regulatory capacities appeared later through complex evolutionary process. Potential key posttranslational modifications were also in place then, with interacting pairs preferentially appearing at the same evolutionary time, although modifications often led to the subsequent acquisition of new targets afterwards. We also found extensive gene loss in essential modules of the regulatory network in fungi, plants, and arthropods, important for their validation as model organisms for DDR studies.

  16. DDR、DDR2谁也跑不了顶星TM 915PD2

    Institute of Scientific and Technical Information of China (English)



  17. FY12 End of Year Report for NEPP DDR2 Reliability (United States)

    Guertin, Steven M.


    This document reports the status of the NEPP Double Data Rate 2 (DDR2) Reliability effort for FY2012. The task expanded the focus of evaluating reliability effects targeted for device examination. FY11 work highlighted the need to test many more parts and to examine more operating conditions, in order to provide useful recommendations for NASA users of these devices. In order to develop these approaches, it is necessary to develop test capability that can identify reliability outliers. To do this we must test many devices to ensure outliers are in the sample, and we must develop characterization capability to measure many different parameters. For FY12 we increased capability for reliability characterization and sample size. We increased sample size by moving from loose devices to DIMMs with an approximate reduction of 20 to 50 times in terms of per DUT cost. By increasing sample size we have improved our ability to characterize devices that may be considered reliability outliers. This report provides an update on the effort to improve DDR2 testing capability. Although focused on DDR2, the methods being used can be extended to DDR and DDR3 with relative ease.

  18. 勤茂TwinMOS推出Mac系列DDR2内存

    Institute of Scientific and Technical Information of China (English)


    Mac计算机结合时尚与科技的设计,一向受雅痞新贵们的喜爱。近日,勤茂宣布推出Mac专用DDR2内存——Apple Series,此款Mac专用的DDR2内存,承袭Mac产品系列一贯的纯白包装。勤茂Apple Series内存全部通过Mac Book、Mac Mini和Mac Book Pro等机型的实机严格测试,兼容Mac系列所有DDR2规格的机型,并可稳定运作。所有的勤茂内存模块都提供全球终身保固的服务。

  19. Targeting DDR2 in head and neck squamous cell carcinoma with dasatinib. (United States)

    von Mässenhausen, Anne; Sanders, Christine; Brägelmann, Johannes; Konantz, Martina; Queisser, Angela; Vogel, Wenzel; Kristiansen, Glen; Duensing, Stefan; Schröck, Andreas; Bootz, Friedrich; Brossart, Peter; Kirfel, Jutta; Lengerke, Claudia; Perner, Sven


    Squamous cell carcinoma of the head and neck (HNSCC) is the tenth most common tumor entity in men worldwide. Nevertheless therapeutic options are mostly limited to surgery and radio-chemotherapy resulting in 5-year survival rates of around 50%. Therefore new therapeutic options are urgently needed. During the last years, targeting of receptor tyrosine kinases has emerged as a promising strategy that can complement standard therapeutical approaches. Here, we aimed at investigating if the receptor tyrosine kinase DDR2 is a targetable structure in HNSCC. DDR2 expression was assessed on a large HNSCC cohort (554 patients) including primary tumors, lymph node metastases and recurrences and normal mucosa as control. Subsequently, DDR2 was stably overexpressed in two different cell lines (FaDu and HSC-3) using lentiviral technology. Different tumorigenic properties such as proliferation, migration, invasion, adhesion and anchorage independent growth were assessed with and without dasatinib treatment using in-vitro cell models and in-vivo zebrafish xenografts. DDR2 was overexpressed in all tumor tissues when compared to normal mucosa. DDR2 overexpression led to increased migration, invasion, adhesion and anchorage independent growth whereas proliferation remained unaltered. Upon dasatinib treatment migration, invasion and adhesion could be inhibited in-vitro and in-vivo whereas proliferation was unchanged. Our data suggest treatment with dasatinib as a promising new therapeutic option for patients suffering from DDR2 overexpressing HNSCC. Since dasatinib is already FDA-approved we propose to test this drug in clinical trials so that patients could directly benefit from this new treatment option.

  20. Adaptive responses to dasatinib-treated lung squamous cell cancer cells harboring DDR2 mutations. (United States)

    Bai, Yun; Kim, Jae-Young; Watters, January M; Fang, Bin; Kinose, Fumi; Song, Lanxi; Koomen, John M; Teer, Jamie K; Fisher, Kate; Chen, Yian Ann; Rix, Uwe; Haura, Eric B


    DDR2 mutations occur in approximately 4% of lung squamous cell cancer (SCC) where the tyrosine kinase inhibitor dasatinib has emerged as a new therapeutic option. We found that ERK and AKT phosphorylation was weakly inhibited by dasatinib in DDR2-mutant lung SCC cells, suggesting that dasatinib inhibits survival signals distinct from other oncogenic receptor tyrosine kinases (RTK) and/or compensatory signals exist that dampen dasatinib activity. To gain better insight into dasatinib's action in these cells, we assessed altered global tyrosine phosphorylation (pY) after dasatinib exposure using a mass spectrometry-based quantitative phosphoproteomics approach. Overlaying protein-protein interaction relationships upon this dasatinib-regulated pY network revealed decreased phosphorylation of Src family kinases and their targets. Conversely, dasatinib enhanced tyrosine phosphorylation in a panel of RTK and their signaling adaptor complexes, including EGFR, MET/GAB1, and IGF1R/IRS2, implicating a RTK-driven adaptive response associated with dasatinib. To address the significance of this observation, these results were further integrated with results from a small-molecule chemical library screen. We found that dasatinib combined with MET and insulin-like growth factor receptor (IGF1R) inhibitors had a synergistic effect, and ligand stimulation of EGFR and MET rescued DDR2-mutant lung SCC cells from dasatinib-induced loss of cell viability. Importantly, we observed high levels of tyrosine-phosphorylated EGFR and MET in a panel of human lung SCC tissues harboring DDR2 mutations. Our results highlight potential RTK-driven adaptive-resistant mechanisms upon DDR2 targeting, and they suggest new, rationale cotargeting strategies for DDR2-mutant lung SCC.

  1. Synthesis and sonication-induced assembly of Si-DDR particles for close-packed oriented layers. (United States)

    Kim, Eunjoo; Cai, Wanxi; Baik, Hionsuck; Nam, Jaewook; Choi, Jungkyu


    Here, we report a seeded growth protocol for synthesizing monodisperse Si-DDR particles of ~1.3-10 μm by varying the seed amount. These Si-DDR particles were deposited onto porous α-Al2O3 discs via sonication-induced assembly, constituting close-packed h0h-oriented layers.

  2. The Enhanced Workflow and Efficiency of the Wireless Local Area Network (WLAN)-Based Direct Digital Radiography (DDR) Portable Radiography. (United States)

    Ngan, Tsz-Lung; Wong, Edward Ting-Hei; Ng, Kris Lap-Shun; Jeor, Patrick Kwok-Shing; Lo, Gladys Goh


    With the implementation of the PACS in the hospital, there is an increasing demand from the clinicians for immediate access and display of radiological images. Recently, our hospital has installed the first wireless local area network (WLAN)-based direct digital radiography (DDR) portable radiography system. The DDR portable radiography system allows wireless retrieval of modality worklist and wireless transmission of portable X-ray image on the console to the Picture Archiving and Communication System (PACS), via WLAN connection of wireless fidelity (Wi-Fi). The aim of this study was to analyze the workflow and performance between the WLAN-based DDR portable radiography system and the old practice using conventional portable X-ray machine with computed radiography (CR) system. A total of 190 portable chest X-ray examinations were evaluated and timed, using the conventional portable X-ray machine with CR from March to April of 2012 and using the new DDR portable radiography system on December of 2012 (n = 97 for old system and n = 93 for DDR portable system). The time interval of image becoming available to the PACS using the WLAN-based DDR portable radiography system was significantly shorter than that of the old practice using the conventional portable X-ray machine with CR (6.8 ± 2.6 min for DDR portable system; 23 ± 10.2 min for old system; p DDR portable radiography system can enhance the workflow of portable radiography by reduction of procedural steps.

  3. HYS72T512022HF-3.7-A:4GB DDR2 FB—DIMM

    Institute of Scientific and Technical Information of China (English)


    Infineon公司推出首个DDR2全缓冲双列直插存储器模块(FB—DIMM),其容量从512MB-4GB。新的FB—DIMM是基于先进存储器缓冲器(AMB)芯片,DDR2 DRAM芯片和有所有权的热沉都是Infineon的产品。此外,Infineon还给其它的FB—DIMM制造商提供AMB逻辑芯片。

  4. A Novel Delay-locked Loop Structure for DDR SDRAM Controller%一种适用于DDR SDRAM控制器的DLL新结构

    Institute of Scientific and Technical Information of China (English)

    叶波; 罗敏; 王紫石


    提出了一种适用于DDR SDRAM控制器的DLL新结构,在不同的工艺、电压和温度(PVT)条件下,DDRSDRAM的数据经过传输线传输后均能被器件采样到正确的数据.采用256M 133MHz DDR SDRAM和1.5V、0.16μmCMOS标准单元库,模拟和测试结果都表明了该结构的正确性.该结构同样可用于其它不同PVT条件下需要固定延迟的电路.

  5. DDR-SDRAM量身定制的高效电源管理芯片%Efficient Power Management ICs Tailored for DDR-SDRAM Memories

    Institute of Scientific and Technical Information of China (English)




  6. 3D PLUS HI-REL DDR2 Termination Regulator Module- A Building Block Function for High Reliability SDRAM DDR2 System Architecture (United States)

    Perrot, Nicolas; Dubus, Patrick; Garcia-Sanchez, Esther


    Memory system architectures using DDR2 technology need to be compliant with JEDEC JESD8-15A standard [1]. Therefore a bus termination regulator able to sink and source current while regulating VTT voltage is used for this purpose. Such module has been developed by 3D PLUS and is the first space qualified DDR Termination Regulator (DDR2-TR) available on the market. It is based on an innovative Bang-Bang regulation principle, chosen for its speed performance and to guarantee an output voltage that remains within the predefined limits regardless of any output current transients. The output filter type is selected to make the module rugged to any overload condition without complex protection circuits. The module has been specifically designed for low input voltage, low noise and high reliability systems where space is a key consideration. The module uses the 3D PLUS SIP (System-In-Package) technology embedding 3 stacked PCBs. No external filters or decoupling capacitors are needed.

  7. Schriftstellerinnen der DDR und feministisches Bewußtsein im Staatssozialismus

    Directory of Open Access Journals (Sweden)

    Eva Kaufmann


    Full Text Available Seit den 1960er Jahren produzierten Schriftstellerinnen in der DDR wie Christa Wolf, Irmtraud Morgner, Sarah Kirsch, Brigitte Reimann, Charlotte Worgitzky, Lia Pirskawetz, und Maya Wiens eine vielfältige Literatur zu frauenrelevanten Themen. Den Obertitel „The Promised Land“ (das gelobte Land hat Lorna Martens Irmtraud Morgner entlehnt, der Autorin, die sie neben Christa Wolf als wichtigste Zeugin für „feminist writing“ in der DDR betrachtet. In Morgners Roman Leben und Abenteuer der Trobadora Beatriz steht der Begriff „gelobtes Land“ bezogen auf die DDR in einem ironischen Zusammenhang. Mit simplem Jaja oder Neinnein ist diesem „Ort des Wunderbaren“ (Morgner nicht beizukommen. Vergleichbares signalisiert auch das Fragezeichen, das Martens hinter den Begriff „Promised Land“ setzt. Der anspielungsreiche Verweis auf das Land erscheint auch insofern nützlich, als die Eigenart feministischen Schreibens genauer zu fassen ist, wenn über das Land selbst, namentlich seine Frauenpolitik, Auskünfte gegeben werden. Lorna Martens möchte herausfinden, wie Schriftstellerinnen in der DDR feministisches Bewusstsein artikuliert haben, d.h. feministisches Bewusstsein unter den vom Staatssozialismus geschaffenen Bedingungen.

  8. DDR2 overexpression in urothelial carcinoma indicates an unfavorable prognosis: a large cohort study. (United States)

    Tsai, Meng-Chen; Li, Wei-Ming; Huang, Chun-Nung; Ke, Hung-Lung; Li, Ching-Chia; Yeh, Hsin-Chih; Chan, Ti-Chun; Liang, Peir-In; Yeh, Bi-Wen; Wu, Wen-Jeng; Lim, Sher-Wei; Li, Chien-Feng


    The migration ability of urothelial carcinoma corresponding to dismal prognosis had not been fully investigated. The interaction of extracellular collagen with a unique transmembrane receptor tyrosine kinase, Discoidin domain receptor 2 (DDR2), was selected by data mining. We arranged real-time reverse transcription polymerase chain reaction assays to evaluate the transcript levels in 26 urinary tract urothelial carcinoma and 26 urinary bladder urothelial carcinoma specimens, showing significantly increase corresponding to advanced primary stage (p = 0.003 and p DDR2 expression in 340 urinary tract urothelial carcinoma and 295 urinary bladder urothelial carcinoma. Assessments of the correlation to clinicopathologic features, disease-specific survival, and metastasis-free survival were conducted. The transcript levels in advanced stage were higher than those in early stage and were correlated with poor prognosis. The higher expression was positively correlated to higher pT status (p DDR2 resulted in a depletion of cellular viability, migratory, and invasive ability, supporting the oncogenic function of DDR2.

  9. An essential role of discoidin domain receptor 2 (DDR2) in osteoblast differentiation and chondrocyte maturation via modulation of Runx2 activation. (United States)

    Zhang, Yan; Su, Jin; Yu, Jiangtian; Bu, Xin; Ren, Tingting; Liu, Xinping; Yao, Libo


    Discoidin domain receptor 2 (DDR2) belongs to receptor tyrosine kinase (RTK) family and is activated by collagen binding. Although the bone defects in Ddr2 null mice have been reported for a decade, the molecular mechanism remains unclear. This study sought to investigate the function and detailed mechanism of DDR2 in osteogenic and chondrogenic differentiation. Herein we found that in preosteoblastic cells, DDR2 activation was enhanced by osteogenic induction but was not paralleled with the alteration of DDR2 expression. Under differentiated condition, downregulation of endogenous DDR2 through specific shRNA dramatically repressed osteoblastic marker gene expression and osteogenic differentiation. Enforced expression of constitutively activated DDR2 increased the expression of bone markers in both undifferentiated and differentiated osteoblasts. Importantly, molecular evidence showed that DDR2 regulated the transactivity of Runx2, a master transcription factor involved in skeletal development, by modulating its phosphorylation. Analysis of candidate protein kinases indicated that extracellular signal-regulated kinase (ERK) activation is responsive to DDR2 signaling and involved in DDR2 regulation of Runx2 phosphorylation and transcriptional activity. Notably, a gain-of-function mutant of Runx2 with enhanced ERK-independent phosphorylation rescued the impaired osteogenic phenotypes observed in Ddr2-silenced cells, whereas a Runx2 mutant devoid of phosphorylation regulation by ERK inhibited DDR2 induction of osteogenesis. In addition, DDR2 facilitated Runx2 transactivation and type X collagen expression in hypertrophic chondrocytes. Thus this study reveals for the first time that DDR2 plays an essential role in osteoblast and chondrocyte differentiation. The mechanism disclosure may provide therapeutic targets for human genetic disorders caused by DDR2 deficiency.

  10. Heterojunction DDR THz IMPATT diodes based on AlxGa1-xN/GaN material system (United States)

    Banerjee, Suranjana; Mitra, Monojit


    Simulation studies are made on the large-signal RF performance and avalanche noise properties of heterojunction double-drift region (DDR) impact avalanche transit time (IMPATT) diodes based on AlxGa1-xN/GaN material system designed to operate at 1.0 THz frequency. Two different heterojunction DDR structures such as n-Al0.4Ga0.6N/p-GaN and n-GaN/p-Al0.4Ga0.6N are proposed in this study. The large-signal output power, conversion efficiency and noise properties of the heterojunction DDR IMPATTs are compared with homojunction DDR IMPATT devices based on GaN and Al0.4Ga0.6N. The results show that the n-Al0.4Ga0.6N/p-GaN heterojunction DDR device not only surpasses the n-GaN/p-Al0.4Ga0.6N DDR device but also homojunction DDR IMPATTs based on GaN and Al0.4Ga0.6N as regards large-signal conversion efficiency, power output and avalanche noise performance at 1.0 THz.

  11. Large signal and noise properties of heterojunction Al x Ga1-x As/GaAs DDR IMPATTs (United States)

    Banerjee, Suranjana; Mitra, Monojit


    Simulation studies are carried out on the large signal and noise properties of heterojunction (HT) Al x Ga1-x As/GaAs double drift region (DDR) IMPATT devices at V-band (60 GHz). The dependence of Al mole fraction on the aforementioned properties of the device has been investigated. A full simulation software package has been indigenously developed for this purpose. The large signal simulation is based on a non-sinusoidal voltage excitation model. Three mole fractions of Al and two complementary HT DDR structures for each mole fraction i.e., six DDR structures are considered in this study. The purpose is to discover the most suitable structure and corresponding mole fraction at which high power, high efficiency and low noise are obtained from the device. The noise spectral density and noise measure of all six HT DDR structures are obtained from a noise model and simulation method. Similar studies are carried out on homojunction (HM) DDR GaAs IMPATTs at 60 GHz to compare their RF properties with those of HT DDR devices. The results show that the HT DDR device based on N-Al x Ga1-x As/p-GaAs with 30% mole fraction of Al is the best one so far as large signal power output, DC to RF conversion efficiency and noise level are concerned.

  12. Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing. (United States)

    Rossiello, Francesca; Herbig, Utz; Longhese, Maria Pia; Fumagalli, Marzia; d'Adda di Fagagna, Fabrizio


    The DNA damage response (DDR) orchestrates DNA repair and halts cell cycle. If damage is not resolved, cells can enter into an irreversible state of proliferative arrest called cellular senescence. Organismal ageing in mammals is associated with accumulation of markers of cellular senescence and DDR persistence at telomeres. Since the vast majority of the cells in mammals are non-proliferating, how do they age? Are telomeres involved? Also oncogene activation causes cellular senescence due to altered DNA replication and DDR activation in particular at the telomeres. Is there a common mechanism shared among apparently distinct types of cellular senescence? And what is the role of telomeric DNA damage?

  13. 超高频GB级的诱惑——博帝战斧DDR2 1066内存

    Institute of Scientific and Technical Information of China (English)



    全新构架的AM2 Athlon64完全支持DDR2 800内存,与Intel发展道路相同,各内存品牌也纷纷推出更高端的DDR2产品。作为美国知名的高端内存品牌,Patriot Memory(博帝内存)最近也在中国内地市场推出了其战斧系列DDR2 1066(PC2-8500)内存。

  14. Aircraft electromagnetic compatibility (United States)

    Clarke, Clifton A.; Larsen, William E.


    Illustrated are aircraft architecture, electromagnetic interference environments, electromagnetic compatibility protection techniques, program specifications, tasks, and verification and validation procedures. The environment of 400 Hz power, electrical transients, and radio frequency fields are portrayed and related to thresholds of avionics electronics. Five layers of protection for avionics are defined. Recognition is given to some present day electromagnetic compatibility weaknesses and issues which serve to reemphasize the importance of EMC verification of equipment and parts, and their ultimate EMC validation on the aircraft. Proven standards of grounding, bonding, shielding, wiring, and packaging are laid out to help provide a foundation for a comprehensive approach to successful future aircraft design and an understanding of cost effective EMC in an aircraft setting.

  15. 小RNA干扰DDR2基因表达对肝星状细胞的影响%Effects of siRNA targeting DDR2 on hepatic stellate cells

    Institute of Scientific and Technical Information of China (English)

    张广林; 罗蒙; 孙勇伟; 徐庆; 陈炜


    Objective To explore the effects of inhibiting DDR2 expression by siRNA on hepatic stellate cells and evaluate the role of DDR2 gene in hepatic fibrogenesis. Methods (1) Three pairs of chemically synthesized siRNAs targeting DDR2 were respectively transfected into HSC-T6 cells for evaluation of silence efficacy, and the most effective siRNA was used. (2) HSC-T6 cells were divided into three groups, group A served as normal controls, group B served as negative control and group C was RNA interference DDR2 (siRNA-DDR2) expression of HSC. The most effective RNA interference sequences targeting DDR2 gene was chosen to transfect HSC-T6 cells by plasmid transfection. The tendency of DDR2, α-smooth muscle actin(α-SMA) and collagen-Ⅰ mRNA expression were estimated using RT-PCR, and the protein expression of DDR2 was evaluated by Western blot. Meanwhile, MTT assay was employed to analyze the proliferation of HSC. Results (1) DDR2 siRNA, which began at nt 868, inhibited DDR2 gone expression stronger than the other two siRNAs. (2) After transfection of siRNA-DDR2, the mRNA expression of DDR2 (P<0.01) and α-SMA (P<0.01) significantly decreased compared with the normal group, and the protein expression of DDR2 also significantly decreased (P<0.01). In addition, the proliferation of HSC was also markedly suppressed as compared with the normal group (P<0.01). However, compared with the negative control group, none of them was markedly suppressed. Conclusion SiRNA targeting DDR2 significantly suppresses the activation, proliferation of HSC, and thus attenuates hepatic fibrogonesis in vitro.%目的 探讨siRNA干扰大鼠盘状结构域受体2(discoidin domain receptor2,DDB2)基因对肝星状细胞(hepatic stellate cell,HSC)的影响,评估DDR2在肝纤维化发生中的作用.方法 (1)化学合成3对针对DDR2基因的siRNAs,转染肝星状细胞株(HSC-T6),筛选抑制效率最高的siRNA用于干扰实验;(2)将肝星状细胞株HSC-T6分为3组:正常

  16. Centering a DDR Strobe in the Middle of a Data Packet (United States)

    Johnson, Michael; Nelson, Dave; Seefeldt, James; Roper, Weston; Passow, Craig


    The Orion CEV Northstar ASIC (application- specific integrated circuit) project required a DDR (double data rate) memory bus driver/receiver (DDR PHY block) to interface with external DDR memory. The DDR interface (JESD79C) is based on a source synchronous strobe (DQS\\) that is sent along with each packet of data (DQ). New data is provided concurrently with each edge of strobe and is sent irregularly. In order to capture this data, the strobe needs to be delayed and used to latch the data into a register. A circuit solves the need for training a DDR PRY block by incorporating a PVT-compensated delay element in the strobe path. This circuit takes an external reference clock signal and uses the regular clock to calibrate a known delay through a data path. The compensated delay DQS signal is then used to capture the DQ data in a normal register. This register structure can be configured as a FIFO (first in first out), in order to transfer data from the DDR domain to the system clock domain. This design is different in that it does not rely upon the need for training the system response, nor does it use a PLL (phase locked loop) or a DLL (delay locked loop) to provide an offset of the strobe signal. The circuit is created using standard ASIC building blocks, plus the PVT (process, voltage, and temperature) compensated delay line. The design uses a globally available system clock as a reference, alleviating the need to operate synchronously with the remote memory. The reference clock conditions the PVT compensated delay line to provide a pre-determined amount of delay to any data signal that passes through this delay line. The delay line is programmed in degrees of offset, so that one could think of the clock period representing 360deg of delay. In an ideal environment, delaying the strobe 1/4 of a clock cycle (90deg) would place the strobe in the middle of the data packet. This delayed strobe can then be used to clock the data into a register, satisfying setup and

  17. Targeting of Discoidin Domain Receptor 2 (DDR2) Prevents Myofibroblast Activation and Neovessel Formation During Pulmonary Fibrosis. (United States)

    Zhao, Hu; Bian, Huan; Bu, Xin; Zhang, Shuya; Zhang, Pan; Yu, Jiangtian; Lai, Xiaofeng; Li, Di; Zhu, Chuchao; Yao, Libo; Su, Jin


    Idiopathic pulmonary fibrosis (IPF) is a lethal human disease with short survival time and few treatment options. Herein, we demonstrated that discoidin domain receptor 2 (DDR2), a receptor tyrosine kinase that predominantly transduces signals from fibrillar collagens, plays a critical role in the induction of fibrosis and angiogenesis in the lung. In vitro cell studies showed that DDR2 can synergize the actions of both transforming growth factor (TGF)-β and fibrillar collagen to stimulate lung fibroblasts to undergo myofibroblastic changes and vascular endothelial growth factor (VEGF) expression. In addition, we confirmed that late treatment of the injured mice with specific siRNA against DDR2 or its kinase inhibitor exhibited therapeutic efficacy against lung fibrosis. Thus, this study not only elucidated novel mechanisms by which DDR2 controls the development of pulmonary fibrosis, but also provided candidate target for the intervention of this stubborn disease.

  18. PCB layout between MPC8379E and DDR2 and the simulation design%MPC8379E与DDR2之间的PCB布线及仿真设计

    Institute of Scientific and Technical Information of China (English)

    程增艳; 吴骏


    研究了MPC8379E处理器的相关资料和DDR2的特性,以及它们之间PCB布线的规则和仿真设计.由于MPC8379E和DDR2都具有相当高的工作频率,所以他们之间的走线必须满足高速PCB布线规则,还要结合实际系统中的层叠、阻抗等,采取特殊布线方法.本文使用EDA工具Cadence仿真设计了DDR2拓扑结构和信号完整性.%In this paper, we researched the relative materials of MPC8379E and the features of DDR2 technology, and then some design guidelines and simulation design are described. As the MPC8379E and DDR2 has a very high work speed, so the PCB layout between them should be high-speed PCB layout, and combine with the stack and resistance of the actual system, take special method. This paper presents the simulation design of topology of DDR2 signals and the signal integrity through the use of Cadence software.

  19. 利用重新排序型控制器提升DDR SDRAM的效率

    Institute of Scientific and Technical Information of China (English)

    Leith Johnson


    @@ 高速双倍数据速率(DDR)SDRAM厂商一般均使用峰值数据传输速率来指定器件规格.比如,如果某厂商把产品命名为DDR3-1600,则意味着该厂商将规定该SDRAM器件的峰值传输速率定为1,600 MT/s.

  20. 利用重新排序型控制器提升DDR SDRAM的效率

    Institute of Scientific and Technical Information of China (English)

    Leith Johnson


    @@ 高速双倍数据速率(DDR)SDRAM厂商一般均使用峰值数据传输速率来制定器件规格.比如,如果某厂商把产品命名为DDR3-1600,则意味着该厂商将规定该SDRAM器件的峰值传输速率定为1,600 MT/s.

  1. DUPIC fuel compatibility assessment

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Hang Bok; Rho, G. H.; Park, J. W. [and others


    The purpose of this study is to assess the compatibility of DUPIC(Direct Use of Spent PWR Fuel in CANDU Reactors) fuel with the current CANDU 6 reactor, which is one of the technology being developed to utilize the spent PWR fuel in CANDU reactors. The phase 1 study of this project includes the feasibility analysis on applicability of the current core design method, the feasibility analysis on operation of the DUPIC fuel core, the compatibility analysis on individual reactor system, the sensitivity analysis on the fuel composition, and the economic analysis on DUPIC fuel cycle. The results of the validation calculations have confirmed that the current core analysis system is acceptable for the feasibility study of the DUPIC fuel compatibility analysis. The results of core simulations have shown that both natural uranium and DUPIC fuel cores are almost the same from the viewpoint of the operational performance. For individual reactor system including reactively devices, the functional requirements of each system are satisfied in general. However, because of the pronounced power flattening in the DUPIC core, the radiation damage on the critical components increases, which should be investigated more in the future. The DUPIC fuel composition heterogeneity dose not to impose any serious effect on the reactor operation if the fuel composition is adjusted. The economics analysis has been performed through conceptual design studies on the DUPIC fuel fabrication, fuel handling in a plant, and spent fuel disposal, which has shown that the DUPIC fuel cycle is comparable to the once-trough fuel cycle considering uncertainties associated with unit costs of the fuel cycle components. The results of Phase 1 study have shown that it is feasible to use the DUPIC fuel in CANDU reactors without major changes in hardware. However further studies are required to confirm the safety of the reactor under accident condition.

  2. Noise Performance of Heterojunction DDR MITATT Devices Based on at W-Band

    Directory of Open Access Journals (Sweden)

    Suranjana Banerjee


    Full Text Available Noise performance of different structures of anisotype heterojunction double-drift region (DDR mixed tunneling and avalanche transit time (MITATT devices has been studied. The devices are designed for operation at millimeter-wave W-band frequencies. A simulation model has been developed to study the noise spectral density and noise measure of the device. Two different mole fractions and of Ge and corresponding four types of device structure are considered for the simulation. The results show that the -Si heterojunction DDR structure of MITATT device excels all other structures as regards noise spectral density ( sec and noise measure (33.09 dB as well as millimeter-wave properties such as DC-to-RF conversion efficiency (20.15% and CW power output (773.29 mW.

  3. Increased expression of discoidin domain receptor 2 (DDR2): a novel independent prognostic marker of worse outcome in breast cancer patients. (United States)

    Ren, Tingting; Zhang, Jian; Zhang, Jing; Liu, Xinping; Yao, Libo


    The discoidin domain receptors, DDR1 and DDR2, have been linked with numerous human cancers. We sought to determine expression level and distribution of DDRs in human breast cancer, and investigate prognostic determinates to determine whether levels of DDRs could predict survival. Tumor samples from 122 breast cancer patients were analyzed for relative expression of DDRs. An additional 24 matched tumor and normal tissues were tested for differential expression of DDR1 and DDR2. DDR2 was found to be significantly increased by 6-fold (P = 0.0005) and DDR1 decreased (P = 0.0001) in tumor vs. normal breast tissue. DDR1 expression was not predictive for patient survival; however, DDR2 expression was significantly associated with disease-free (HR = 0.55, 95 % CI = 0.24-0.78, P = 0.026) and overall survival (HR = 0.46, 95 % CI = 0.35-0.84, P = 0.019). Multivariate analysis revealed DDR2 is an independent favorable predictor for prognosis independent of tumor stage, histology, and patient age. The present research provided the first evidence that increased DDR2 mRNA expression in primary human breast cancer might be a powerful, independent predictor of recurrence and outcome.

  4. Kingmax笔记本专用DDR Ⅱ内存Venus美丽登场

    Institute of Scientific and Technical Information of China (English)


    继“Mars战神”DDRⅡ台式机内存系列赢得业界和消费者好评之后,内存厂商Kingmax再次以古罗马神话中的“美神Venus”为其DDRⅡ笔记本专用内存系列命名,同时全新包装的Venus系列DDR Ⅱ SO-DIMM翩然降临至我们身旁。

  5. DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging. (United States)

    Olivieri, Fabiola; Albertini, Maria Cristina; Orciani, Monia; Ceka, Artan; Cricca, Monica; Procopio, Antonio Domenico; Bonafè, Massimiliano


    A major issue in aging research is how cellular phenomena affect aging at the systemic level. Emerging evidence suggests that DNA damage response (DDR) signaling is a key mechanism linking DNA damage accumulation, cell senescence, and organism aging. DDR activation in senescent cells promotes acquisition of a proinflammatory secretory phenotype (SASP), which in turn elicits DDR and SASP activation in neighboring cells, thereby creating a proinflammatory environment extending at the local and eventually the systemic level. DDR activation is triggered by genomic lesions as well as emerging bacterial and viral metagenomes. Therefore, the buildup of cells with an activated DDR probably fuels inflamm-aging and predisposes to the development of the major age-related diseases (ARDs). Micro (mi)-RNAs - non-coding RNAs involved in gene expression modulation - are released locally and systemically by a variety of shuttles (exosomes, lipoproteins, proteins) that likely affect the efficiency of their biological effects. Here we suggest that some miRNAs, previously found to be associated with inflammation and senescence - miR-146, miR-155, and miR-21 - play a central role in the interplay among DDR, cell senescence and inflamm-aging. The identification of the functions of shuttled senescence-associated miRNAs is expected to shed light on the aging process and on how to delay ARD development.

  6. Novel DDR process and materials for front-edge NTD process (United States)

    Shigaki, Shuhei; Takeda, Satoshi; Shibayama, Wataru; Onishi, Ryuji; Nakajima, Makoto; Sakamoto, Rikimaru


    We developed the novel process and material which can prevent the pattern collapse issue perfectly. The process was Dry Development Rinse (DDR) process, and the material used in this process was DDR Material (DDRM). DDRM was containing siloxane polymer which could be replaced the space area of the photo resist pattern. And finally, the reversed pattern would be created by dry etching process without any pattern collapse issue. This novel process was useful not only in positive tone development (PTD) process but also in negative tone development (NTD) process. We newly developed DDRM for NTD process. Novel DDRM consist of special polymer and it used organic solvent system. So, new DDRM showed no mixing property with NTD photo resist and it has enough etch selectivity against NTD photo resist. Image reversal was successfully achieved by combination of NTD process and DDR process keeping good pattern quality. Tone reverse pattern below hp 18nm was obtained without any pattern collapse issue, which couldn't be created by just using normal NTD process.

  7. Doses under automatic exposure control (AEC) for direct digital radiographic (DDR) X-ray systems. (United States)

    Bowden, Louise; Faulkner, Ronan; Clancy, Conor; Gallagher, Aoife; Devine, Mark; Gorman, Dermot; O'Reilly, Geraldine; Dowling, Anita


    Current guidelines quote tolerances for automatic exposure control (AEC) device performance for X-ray systems as 'Baseline ± X %'. However, in the situation where a baseline figure has not yet been achieved, as in the case of commissioning assessments, this tolerance is not relevant. The purpose of this work is to provide mean doses for direct digital radiography (DDR) X-ray system, operating in AEC, against which comparisons can be made. Dose measurements have been recorded under AEC operation on 29 DDR detectors from three different manufacturers. Two different testing protocols were examined: (1) water equivalent phantoms in front of the DDR detector and (2) aluminium block at the tube head. The average patient exit dose, using the aluminium block was 4.6 μGy with the antiscatter grid in place and 4.0 μGy with the grid removed. Using the water phantoms, the average dose was measured at 17.1 μGy with the antiscatter grid in place and 5.4 μGy with grid removed. Based on these results, it is clear that different testing configurations significantly impact on the measured dose.

  8. Large-signal characterization of DDR silicon IMPATTs operating in millimeter-wave and terahertz regime (United States)

    Acharyya, Aritra; Chakraborty, Jit; Das, Kausik; Datta, Subir; De, Pritam; Banerjee, Suranjana; Banerjee, J. P.


    The authors have carried out the large-signal characterization of silicon-based double-drift region (DDR) impact avalanche transit time (IMPATT) devices designed to operate up to 0.5 THz using a large-signal simulation method developed by the authors based on non-sinusoidal voltage excitation. The effect of band-to-band tunneling as well as parasitic series resistance on the large-signal properties of DDR Si IMPATTs have also been studied at different mm-wave and THz frequencies. Large-signal simulation results show that DDR Si IMPATT is capable of delivering peak RF power of 633.69 mW with 7.95% conversion efficiency at 94 GHz for 50% voltage modulation, whereas peak RF power output and efficiency fall to 81.08 mW and 2.01% respectively at 0.5 THz for same voltage modulation. The simulation results are compared with the experimental results and are found to be in close agreement.

  9. Mutations in DDR2 gene cause SMED with short limbs and abnormal calcifications. (United States)

    Bargal, Ruth; Cormier-Daire, Valerie; Ben-Neriah, Ziva; Le Merrer, Martine; Sosna, Jacob; Melki, Judith; Zangen, David H; Smithson, Sarah F; Borochowitz, Zvi; Belostotsky, Ruth; Raas-Rothschild, Annick


    The spondylo-meta-epiphyseal dysplasia [SMED] short limb-hand type [SMED-SL] is a rare autosomal-recessive disease, first reported by Borochowitz et al. in 1993.(1) Since then, 14 affected patients have been reported.(2-5) We diagnosed 6 patients from 5 different consanguineous Arab Muslim families from the Jerusalem area with SMED-SL. Additionally, we studied two patients from Algerian and Pakistani ancestry and the parents of the first Jewish patients reported.(1) Using a homozygosity mapping strategy, we located a candidate region on chromosome 1q23 spanning 2.4 Mb. The position of the Discoidin Domain Receptor 2 (DDR2) gene within the candidate region and the similarity of the ddr2 knockout mouse to the SMED patients' phenotype prompted us to study this gene(6). We identified three missense mutations c.2254 C > T [R752C], c. 2177 T > G [I726R], c.2138C > T [T713I] and one splice site mutation [IVS17+1g > a] in the conserved sequence encoding the tyrosine kinase domain of the DDR2 gene. The results of this study will permit an accurate early prenatal diagnosis and carrier screening for families at risk.

  10. Abnormal Accumulation of Collagen Type I Due to the Loss of Discoidin Domain Receptor 2 (Ddr2 Promotes Testicular Interstitial Dysfunction.

    Directory of Open Access Journals (Sweden)

    Chu-chao Zhu

    Full Text Available Loss of functional allele for discoidin domain receptor 2 (Ddr2 results in impaired Leydig cell response to luteinizing hormone (LH, low testosterone production and arrested spermatogenesis in older male Ddr2slie/slie mice. However, the underlying mechanism responsible for this phenotype remains unknown. Herein, we reported for the first time that the deregulated expression of Ddr2 cognate ligand, namely collagen type I (COL1, may account for the disruption of the testicular steroidogenesis in Ddr2slie/slie mutant testes.Expression of Ddr2 increased gradually along postnatal development, whereas COL1 expression became negligible from adulthood onwards. In Ddr2slie/slie mutant testis, however, in contrast to the undetectable staining of Ddr2, COL1 expression was constantly detected, with the highest values detected during adulthood. In the experimental vasectomy model, Ddr2slie/slie mutant mice exhibited an early androgen deficiency than wild-type mice, along with the accumulation of fibrotic tissue in the interstitium. Functionally, ablation of endogenous Ddr2 resulted in a significant decrease of testosterone (T level in TM3 cells in the presence of higher concentration of COL1 treatment. Conversely, overexpression of Ddr2 could help TM3 cells to maintain a normal testicular steroidogenesis even in the presence of high concentration of COL1. Additionally, attenuated expression of Ddr2 correlates to the deregulated level of serum T levels in human pathological testes.Abnormal accumulation of interstitial COL1 may be responsible for the steroidogenic dysfunction in Ddr2slie/slie mutant testes.

  11. DNA damage response (DDR) induced by topoisomerase II poisons requires nuclear function of the small GTPase Rac. (United States)

    Wartlick, Friedrich; Bopp, Anita; Henninger, Christian; Fritz, Gerhard


    Here, we investigated the influence of Rac family small GTPases on mechanisms of the DNA damage response (DDR) stimulated by topoisomerase II poisons. To this end, we examined the influence of the Rac-specific small molecule inhibitor EHT1864 on Ser139 phosphorylation of histone H2AX, a widely used marker of the DDR triggered by DNA double-strand breaks. EHT1864 attenuated the doxorubicin-stimulated DDR in a subset of cell lines tested, including HepG2 hepatoma cells. EHT1864 reduced the level of DNA strand breaks and increased viability following treatment of HepG2 cells with topo II poisons. Protection by EHT1864 was observed in both p53 wildtype (HepG2) and p53 deficient (Hep3B) human hepatoma cells and, furthermore, remained unaffected upon pharmacological inhibition of p53 in HepG2. Apparently, the impact of Rac on the DDR is independent of p53. Protection from doxorubicin-induced DNA damage by EHT1864 comprises both S and G2 phase cells. The inhibitory effect of EHT1864 on doxorubicin-stimulated DDR was mimicked by pharmacological inhibition of various protein kinases, including JNK, ERK, PI3K, PAK and CK1. EHT1864 and protein kinase inhibitors also attenuated the formation of the topo II-DNA cleavable complex. Moreover, EHT1864 mitigated the constitutive phosphorylation of topoisomerase IIα at positions S1106, S1213 and S1247. Doxorubicin transport, nuclear import/export of topoisomerase II and Hsp90-related mechanisms are likely not of relevance for doxorubicin-stimulated DDR impaired by EHT1864. We suggest that multiple kinase-dependent but p53- and heat shock protein-independent Rac-regulated nuclear mechanisms are required for activation of the DDR following treatment with topo II poisons.

  12. 用品质、稳定打动你——三星金条DDR2 800内存

    Institute of Scientific and Technical Information of China (English)



    随着Intel新一代芯片组对DDR2内存的大力支持,这种下一代高规格内存的已经指日可待。虽然目前的主板芯片组并不支持DDR2 800,但鉴于DDR2 533/667在CL延迟方面的劣势,因此如果不想让成为系统瓶颈的话,那么DDR2 800才是最合适的。

  13. Efficient Power Management IC Tailored for DDR-SDRAM%为DDR-SDRAM度身定造高效功率管理芯片

    Institute of Scientific and Technical Information of China (English)



    引言 DDR—SDRAM,即双数据速率同步DRAM,简称DDR。DDR因其更为卓越的性能(起初的数据速率为266MBps,后来提升至400MBps,而一般SDRAM只有133MBps)、更低的功耗以及更具竞争力的价格,已经在桌面和便携式应用中颇为流行。最近推出的第二代DDR或称DDR2(JESD79—2A),数据速率从400MBps提升到了667MBps。因此与之前的SDRAM技术相比,DDR存储器需要更加复杂和新颖的功率管理结构。

  14. Carbon dioxide and methane transport in DDR zeolite: insights from molecular simulations into carbon dioxide separations in small pore zeolites (United States)

    Jee, Sang Eun; Sholl, David


    Zeolites are good candidates as a membranes for chemical separations because of their excellent chemical and thermal stability. Cage type zeolites are promising materials for gas separation since their narrow windows are expected to control molecular transport. DDR is one of the strongest candidates for light gas separations because of its narrow 8MR window. In our study, we examined the separation selectivity of DDR for CO2/CH4 separation using atomistic simulation methods. We introduced new force fields which can reproduce experimental single component adsorption and diffusion data for this material for the first time. Previously interatomic potentials that have been applied to DDR overestimate experimental diffusivities at least one order of magnitude. We characterized single-component and binary adsorption using Grand Canonical Monte Carlo, and single-component. diffusion using a combination of Molecular Dynamics and Transition State Theory. The most important observation from our calculation is that CO2/CH4 diffusion in DDR is very different from the usual situation in nanoporous materials, where the presence of a slowly diffusing species retards transport rates of a more rapidly diffusing species. In DDR, we show that CO2 diffusion rates are only weakly affected by the presence of CH4, despite the very slow diffusion of the latter species. The physical origins of this unusual behavior are explained by analyzing the adsorption sites and diffusion mechanism for each species.

  15. Acquired resistance to dasatinib in lung cancer cell lines conferred by DDR2 gatekeeper mutation and NF1 loss. (United States)

    Beauchamp, Ellen M; Woods, Brittany A; Dulak, Austin M; Tan, Li; Xu, Chunxiao; Gray, Nathanael S; Bass, Adam J; Wong, Kwok-kin; Meyerson, Matthew; Hammerman, Peter S


    The treatment of non-small cell lung cancer has evolved dramatically over the past decade with the adoption of widespread use of effective targeted therapies in patients with distinct molecular alterations. In lung squamous cell carcinoma (lung SqCC), recent studies have suggested that DDR2 mutations are a biomarker for therapeutic response to dasatinib and clinical trials are underway testing this hypothesis. Although targeted therapeutics are typically quite effective as initial therapy for patients with lung cancer, nearly all patients develop resistance with long-term exposure to targeted drugs. Here, we use DDR2-dependent lung cancer cell lines to model acquired resistance to dasatinib therapy. We perform targeted exome sequencing to identify two distinct mechanisms of acquired resistance: acquisition of the T654I gatekeeper mutation in DDR2 and loss of NF1. We show that NF1 loss activates a bypass pathway, which confers ERK dependency downstream of RAS activation. These results indicate that acquired resistance to dasatinib can occur via both second-site mutations in DDR2 and by activation of bypass pathways. These data may help to anticipate mechanisms of resistance that may be identified in upcoming clinical trials of anti-DDR2 therapy in lung cancer and suggest strategies to overcome resistance.

  16. Integrated Molecular Profiling of Human Gastric Cancer Identifies DDR2 as a Potential Regulator of Peritoneal Dissemination. (United States)

    Kurashige, Junji; Hasegawa, Takanori; Niida, Atsushi; Sugimachi, Keishi; Deng, Niantao; Mima, Kosuke; Uchi, Ryutaro; Sawada, Genta; Takahashi, Yusuke; Eguchi, Hidetoshi; Inomata, Masashi; Kitano, Seigo; Fukagawa, Takeo; Sasako, Mitsuru; Sasaki, Hiroki; Sasaki, Shin; Mori, Masaki; Yanagihara, Kazuyoshi; Baba, Hideo; Miyano, Satoru; Tan, Patrick; Mimori, Koshi


    Peritoneal dissemination is the most frequent, incurable metastasis occurring in patients with advanced gastric cancer (GC). However, molecular mechanisms driving peritoneal dissemination still remain poorly understood. Here, we aimed to provide novel insights into the molecular mechanisms that drive the peritoneal dissemination of GC. We performed combined expression analysis with in vivo-selected metastatic cell lines and samples from 200 GC patients to identify driver genes of peritoneal dissemination. The driver-gene functions associated with GC dissemination were examined using a mouse xenograft model. We identified a peritoneal dissemination-associated expression signature, whose profile correlated with those of genes related to development, focal adhesion, and the extracellular matrix. Among the genes comprising the expression signature, we identified that discoidin-domain receptor 2 (DDR2) as a potential regulator of peritoneal dissemination. The DDR2 was upregulated by the loss of DNA methylation and that DDR2 knockdown reduced peritoneal metastasis in a xenograft model. Dasatinib, an inhibitor of the DDR2 signaling pathway, effectively suppressed peritoneal dissemination. DDR2 was identified as a driver gene for GC dissemination from the combined expression signature and can potentially serve as a novel therapeutic target for inhibiting GC peritoneal dissemination.

  17. Breeding of DDR2 Deficient Mice and Gene Identification of Filial Generation%DDR2基因缺失小鼠的繁育及子代基因型的鉴定

    Institute of Scientific and Technical Information of China (English)

    赵虎; 卜歆; 张淑雅; 任婷婷; 苏金


    目的:探讨盘状结构域受体2(DDR2)基因缺失小鼠的优化繁殖方法与子代小鼠DDR2基因型的鉴定方法,建立DDR2基因缺失小鼠模型,为进一步研究DDR2分子在肿瘤、肺纤维化、类风湿性关节炎等复杂疾病中的功能以及作用机制奠定基础.方法:将从美国JAX实验室引进的三对杂合子小鼠进行饲养并交配繁殖,繁殖成功后其子代中将会出现野生型、杂合子以及纯合子3种基因型.用基因组提取试剂盒试剂盒提取子鼠鼠尾的基因组DNA,经紫外分光光度计定量后,采用Taqman qPCR的方法准确鉴定出小鼠的基因型,同时观察子代小鼠各基因型的比例,并通过小鼠体态观察,进一步证实Taqman qPCR鉴定方法的可靠性.结果:DDR2基因杂合子小鼠互交繁殖可得到DDR2野生型小鼠、DDR2纯合子小鼠以及DDR2杂合子小鼠三种基因型小鼠,所得子代基本符合孟德尔遗传规律,且雌性和雄性DDR2纯合子小鼠体长均较DDR2野生型小鼠和DDR2杂合子小鼠小,鼻子也较其它基因型小鼠明显变短,无繁殖能力.依据Taqman qPCR的结果所得出的纯合子小鼠体貌特征与文献报道一致,证实了Taqman qPCR结果的可靠性.结论:雌、雄性DDR2杂合子小鼠交配可有效获得DDR2基因缺失小鼠;实验所用Taqman qPCR方法能够准确鉴定子代小鼠的基因型,DDR2纯合子小鼠的获得为后续实验的提供了较理想的动物模型.%Objective: To explore the optimized methods of breeding and identification of Discoidin Domain Receptor 2(DDR2) gene deficient mice for laying a foundation for studying the role of DDR2 in tumor, fibrosis, rheumatoid arthritis, and other complex diseases. Methods: Breed and propagate the introduced heterozygote mice from JAX laboratory. Crosses between heterozygotes produced three genotype ofsprings: heterozygotes, homozygous and wild type. Genomic DNA extraction kit was used to extract the genome DNA from the tails of filial

  18. Directional Diffusion Regulator (DDR) for some numerical solvers of hyperbolic conservation laws (United States)

    Jaisankar, S.; Sheshadri, T. S.


    A computational tool called "Directional Diffusion Regulator (DDR)" is proposed to bring forth real multidimensional physics into the upwind discretization in some numerical schemes of hyperbolic conservation laws. The direction based regulator when used with dimension splitting solvers, is set to moderate the excess multidimensional diffusion and hence cause genuine multidimensional upwinding like effect. The basic idea of this regulator driven method is to retain a full upwind scheme across local discontinuities, with the upwind bias decreasing smoothly to a minimum in the farthest direction. The discontinuous solutions are quantified as gradients and the regulator parameter across a typical finite volume interface or a finite difference interpolation point is formulated based on fractional local maximum gradient in any of the weak solution flow variables (say density, pressure, temperature, Mach number or even wave velocity etc.). DDR is applied to both the non-convective as well as whole unsplit dissipative flux terms of some numerical schemes, mainly of Local Lax-Friedrichs, to solve some benchmark problems describing inviscid compressible flow, shallow water dynamics and magneto-hydrodynamics. The first order solutions consistently improved depending on the extent of grid non-alignment to discontinuities, with the major influence due to regulation of non-convective diffusion. The application is also experimented on schemes such as Roe, Jameson-Schmidt-Turkel and some second order accurate methods. The consistent improvement in accuracy either at moderate or marked levels, for a variety of problems and with increasing grid size, reasonably indicate a scope for DDR as a regular tool to impart genuine multidimensional upwinding effect in a simpler framework.

  19. Komponieren als Beruf. Frankreich und die DDR im Vergleich (1950–1980

    Directory of Open Access Journals (Sweden)

    Dorothea Trebesius


    Full Text Available Die Dissertation interessiert sich in systematischer Hinsicht für die Frage „Wer ist ein Komponist?“ und untersucht am Beispiel von Komponisten die Konstruktion und Praxis von Künstlerschaft in der zweiten Hälfte des 20. Jahrhunderts. Sie geht von der These aus, dass sich die Komponisten in dieser Zeit zunehmend dem Modell der Profession annähern. Die Arbeit fragt, wie dieser Prozess der Professionalisierung in Frankreich und der DDR im Vergleich gestaltet wurde und welche Akteure sich daran ...

  20. DNA damage response (DDR) via NKX3.1 expression in prostate cells. (United States)

    Erbaykent-Tepedelen, Burcu; Karamil, Selda; Gonen-Korkmaz, Ceren; Korkmaz, Kemal S


    It has been reported that NKX3.1 an androgen-regulated homeobox gene restricted to prostate and testicular tissues, encodes a homeobox protein, which transcriptionally regulates oxidative damage responses and enhances topoisomerase I re-ligation by a direct interaction with the ATM protein in prostate cells. In this study, we aimed to investigate the role of NKX3.1 in DNA double-strand break (DSB) repair. We demonstrate that the DNA damage induced by CPT-11 (irinotecan, a topo I inhibitor), doxorubicin (a topo II inhibitor), and H2O2 (a mediator of oxidative damage), but not by etoposide (another topo II inhibitor), is negatively influenced by NKX3.1 expression. We also examined γH2AX((S139)) foci formation and observed that the overexpression of NKX3.1 resulted a remarkable decrease in the formation of γH2AX((S139)) foci. Intriguingly, we observed in NKX3.1 silencing studies that the depletion of NKX3.1 correlated with a significant decrease in the levels of p-ATM((S1981)) and γH2AX((S139)). The data imply that the DNA damage response (DDR) can be altered, perhaps via a decrease in the topoisomerase I re-ligation function; this is consistent with the physical association of NKX3.1 with DDR mediators upon treatment of both PC-3 and LNCaP cells with CPT-11. Furthermore, the depletion of NKX3.1 resulted in a G1/S progression via the facilitation of an increase in E2F stabilization concurrent with the suppressed DDR. Thus, the topoisomerase I inhibitor-mediated DNA damage enhanced the physical association of NKX3.1 with γH2AX((S139)) on the chromatin in LNCaP cells, whereas NKX3.1 in the soluble fraction was associated with p-ATM((S1981)) and RAD50 in these cells. Overall, the data suggest that androgens and NKX3.1 expression regulate the progression of the cell cycle and concurrently activate the DDR. Therefore, androgen withdrawal may augment the development of an error-prone phenotype and, subsequently, the loss of DNA damage control during prostate cancer

  1. Kino DDR 82 - Zur Rezeption des Films "Märkische Forschungen"


    Wiedemann, Dieter


    Der vorliegende Bericht resümiert die Ergebnisse einer Befragung, in der 145 Besucher von 7 Filmtheatern zur Akzeptanz des Films "Märkische Forschungen" zu Wort kamen. Die Besucherstruktur sollte für die DDR-Bevölkerung repräsentativ sein, das Alter über 14 Jahre betragen. Die detaillierte Faktorenanalyse der Stellungnahmen zu diesem Film kommt zu folgendem Schluß: "Es kann deshalb angenommen werden, daß der relativ geringe Publikumserfolg der 'Märkischen Forschungen' auch eine Folge des deut...

  2. Discoidin domain receptor 2 (DDR2) promotes breast cancer cell metastasis and the mechanism implicates epithelial-mesenchymal transition programme under hypoxia. (United States)

    Ren, Tingting; Zhang, Wei; Liu, Xinping; Zhao, Hu; Zhang, Jian; Zhang, Jing; Li, Xia; Zhang, Yan; Bu, Xin; Shi, Man; Yao, Libo; Su, Jin


    A wide range of genes involved in breast cancer metastasis have been reported to be related to the microenvironment. We studied the role of discoidin domain receptor 2 (DDR2), a collagen-binding receptor, in breast cancer progression under hypoxic conditions. We showed that DDR2 protein expression closely correlated with the expression of hypoxic marker HIF-1α in clinical breast cancer specimens. The in vitro data demonstrated that hypoxia treatment increased the levels of both expression and phosphorylation of DDR2 in human breast cancer cell lines. In vivo, orthotopic breast tumour xenografts with DDR2 knockdown displayed reduced dissemination and significant prevention in pulmonary and lymphatic metastasis; conversely, these processes were significantly facilitated by the enforced expression of the activated form of DDR2. Further mechanism studies indicated that DDR2 plays an indispensable role in a series of hypoxia-induced behaviours of breast cancer cells, including migration, invasion, and epithelial-mesenchymal transition (EMT). The transcription factor Snail was found to mediate DDR2-induced down-regulation of the cell-cell adhesion molecule E-cadherin. It was also documented that there is a correlation between DDR2 and E-cadherin expression with the presence of lymph node metastases in 160 cases of invasive human breast carcinoma. In addition, we provided evidence that DDR2 silencing in breast cancer cells prevents the hypoxia-induced activation of ERK MAPK, suggesting its potential involvement in mediating the effect of DDR2 on hypoxia-induced signalling. Based on the results of this study, we conclude that DDR2 participates in hypoxia-induced breast cancer metastasis through the regulation of cell migration, invasion, and EMT, and thus may serve as an accessible therapeutic target for the treatment of breast cancer.

  3. Exploring Interpersonal Compatibility in Groups. (United States)

    Keyton, Joann

    This study investigated William Schutz's three-dimensional theory of interpersonal behavior and compatibility (FIRO) to determine its validity as a group measure of compatibility. Data were collected from 248 students enrolled in a multi-section course in small group communications at a large midwestern university. Subjects self-selected…

  4. Compatibility of conditionally specified models. (United States)

    Chen, Hua Yun


    A conditionally specified joint model is convenient to use in fields such as spatial data modeling, Gibbs sampling, and missing data imputation. One potential problem with such an approach is that the conditionally specified models may be incompatible, which can lead to serious problems in applications. We propose an odds ratio representation of a joint density to study the issue and derive conditions under which conditionally specified distributions are compatible and yield a joint distribution. Our conditions are the simplest to verify compared with those proposed in the literature. The proposal also explicitly construct joint densities that are fully compatible with the conditionally specified densities when the conditional densities are compatible, and partially compatible with the conditional densities when they are incompatible. The construction result is then applied to checking the compatibility of the conditionally specified models. Ways to modify the conditionally specified models based on the construction of the joint models are also discussed when the conditionally specified models are incompatible.

  5. Research on the area-interleaved deep storing technology of DSO based on DDR2%基于DDR2的DSO分区交替深存储技术研究

    Institute of Scientific and Technical Information of China (English)

    彭伟; 张沁川; 袁洲


    具有深存储功能的数字存储示波器(DSO),能够将大量的采集数据存储下来,大大提高了采集到的波形数据的信息含量,能够很好的再现波形细节,为工程师分析信号、解决问题提供了极大的便利.设计采用FPGA外挂DDR2 SDRAM颗粒的方式来存储采集数据,并利用FPGA内部的MCB IP核来控制其读写和刷新.以此为基础,研究了基于DDR2 SDRAM颗粒的基本深存储设计方案,提出了分区交替深存储技术,并分析了该技术对提升DSO深存储性能的作用及具体实现方法.该技术解决了示波器停止状态下读取DDR2 SDRAM颗粒数据与写DDR2SDRAM颗粒之间的矛盾,并在实际测试中取得了很好的效果.%DSO with the function of deep storage can save plenty of sampling data and get more information of the signal.This enables us to replay the detail of the wave and provides a very good tool for engineers to analyze signals and solve problems.The design uses the DDR2 SDRAM which is connected outside the FPGA to store the sampling data and uses FPGA's MCB IP core to control it during the reading,writing and refreshing process.Based on this,we studies the basic deep storage method which based on DDR2 SDRAM,raised the area-interleaved storing technology and analyzed how it can improve the deep storage function of the DSO and how to realize it.This technology solves the contradiction between reading DDR2 SDRAM data in DSO's stop status and writing data into DDR2 SDRAM,and a good result has got in testing.

  6. Doses measured using AEC on direct digital radiographic (DDR) X-rays systems: updated results with an RP 162 perspective. (United States)

    Bowden, L; Faulkner, R; Gallagher, A; O'Connor, U; Walsh, C; Dowling, A; O'Reilly, G


    As digital technology in diagnostic radiology systems becomes more prevalent, there is a need to provide comparative dose information for these new systems. This is needed in particular for testing the automatic exposure control (AEC) devices on direct digital radiography (DDR) systems as there is no consensus on the receptor dose level in the current guidelines. The new European Commission RP 162 document sets the suspension level for the 'verification of kerma at receptor entrance in computed radiography and DDR systems under AEC' as ≥10 µGy. This document also notes that alternate methodologies are acceptable, and may require adjustment in the suspension level if used. This study provides a range of typical doses under AEC for DDR systems, for a variety measurement methodologies, including that described in RP 162.

  7. Compatible quantum theory. (United States)

    Friedberg, R; Hohenberg, P C


    Formulations of quantum mechanics (QM) can be characterized as realistic, operationalist, or a combination of the two. In this paper a realistic theory is defined as describing a closed system entirely by means of entities and concepts pertaining to the system. An operationalist theory, on the other hand, requires in addition entities external to the system. A realistic formulation comprises an ontology, the set of (mathematical) entities that describe the system, and assertions, the set of correct statements (predictions) the theory makes about the objects in the ontology. Classical mechanics is the prime example of a realistic physical theory. A straightforward generalization of classical mechanics to QM is hampered by the inconsistency of quantum properties with classical logic, a circumstance that was noted many years ago by Birkhoff and von Neumann. The present realistic formulation of the histories approach originally introduced by Griffiths, which we call 'compatible quantum theory (CQT)', consists of a 'microscopic' part (MIQM), which applies to a closed quantum system of any size, and a 'macroscopic' part (MAQM), which requires the participation of a large (ideally, an infinite) system. The first (MIQM) can be fully formulated based solely on the assumption of a Hilbert space ontology and the noncontextuality of probability values, relying in an essential way on Gleason's theorem and on an application to dynamics due in large part to Nistico. Thus, the present formulation, in contrast to earlier ones, derives the Born probability formulas and the consistency (decoherence) conditions for frameworks. The microscopic theory does not, however, possess a unique corpus of assertions, but rather a multiplicity of contextual truths ('c-truths'), each one associated with a different framework. This circumstance leads us to consider the microscopic theory to be physically indeterminate and therefore incomplete, though logically coherent. The completion of the theory

  8. Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors (United States)


    The structure-based design of 1, 2, 3, 4-tetrahydroisoquinoline derivatives as selective DDR1 inhibitors is reported. One of the representative compounds, 6j, binds to DDR1 with a Kd value of 4.7 nM and suppresses its kinase activity with an IC50 value of 9.4 nM, but it is significantly less potent for a panel of 400 nonmutated kinases. 6j also demonstrated reasonable pharmacokinetic properties and a promising oral therapeutic effect in a bleomycin-induced mouse pulmonary fibrosis model. PMID:27219676

  9. UV/Fenton photo-oxidation of Drimarene Dark Red (DDR) containing textile-dye wastewater (United States)

    Hudaya, T.; Anthonios, J.; Septianto, E.


    Textile dye wastewater contains organic pollutants which are non-biodegradable, characterized by low BOD/COD ratio of typically treat such wastewater, the destructive wastewater treatment methods which can be utilized are the Advanced Oxidation Processes (AOPs). One of the AOPs method which is the UV/H2O2/Fe2+ (or UV/Fenton) offers not only relatively low cost but also quite effective (in terms of color removal and reaction time) treatment. This particular research aimed to optimize the conditions of UV/Fenton photo-oxidation process for Drimarene Dark Red containing textile- dye wastewater. The two main operating conditions to be optimized were the initial concentration of H2O2 ranged between 0.022-0.078 %-w and the mol ratio of Fe2+: H2O2 was varied from 1: 13 up to 1: 45, using the Central Composite Design experimental matrix. The photo-oxidation was carried out at the optimum pH of 3 from some previous experiments. The best processing conditions of the photo-oxidation of Drimarene Dark Red (DDR) were found at the initial concentration of H2O2 at 0.050%-w and the mole ratio Fe2+: H2O2 of 1: 22. Under these conditions, the measured 2nd order pseudo-rate constantwas 0.021 M-1.min-1. The DDR color removal of 90% was surprisingly achievable within only 10 minutes reaction time.

  10. 双通道,2GB都没用——DDR2内存实用测试

    Institute of Scientific and Technical Information of China (English)



  11. 频率、时序都不可忽略 DDR2内存超频私家秘笈

    Institute of Scientific and Technical Information of China (English)





    The compatibility of dense non-aqueous phase liquids (DNAPLs), trichloroethylene (TCE), methylene chloride (MC), and creosote with commercially available sodium bentonite pellets was evaluated using stainless steel, double-ring, falling-head permeameters. The Hydraulic conductiv...

  13. Design of DDR2-SDRAM Interface in High-speed Image Processing System%高速图像处理系统中DDR2-SDRAM接口的设计

    Institute of Scientific and Technical Information of China (English)

    陈雨; 陈科; 安涛


    To meet the requirements of wide interface bandwidth and large capacity storage for the high-speed image processing systems, a method to connect FPGA with DDR2-SDRAM is adopted. A scheme of DDR2-SDRAM controller based on VHDL language is proposed. A simple image processing platform was established on a Xilinx ML506 board. An experiment of continuous read-write of standard VGA image data was conducted. The clear and consequent images were obtained on the display. The interface has the characteristics of simple structure and high-speed access to images.%为了满足高速图像处理系统中需要高接口带宽和大容量存储的目的,采用了FPGA外接DDR2-SDRAM的设计方法,提出一种基于VHDL语言的DDR2-SDRAM控制器的方案,针对高速图像处理系统中的具体情况,在Xilinx的ML506开发板上搭建了简单的图像处理系统平台并进行了连续读/写标准VGA格式图像数据的实验,在显示端得到了清晰不掉帧的图像结果,具有结构简单和高速存取图像的特点.

  14. 基于DDR IP核视频图像缓存的设计与实现%Design and Implement of Video Image Buffer Based on DDR IP Core

    Institute of Scientific and Technical Information of China (English)

    熊璟; 唐广; 唐湘成; 黄自力


    Nowadays, memory which have big capability and high-speed in image collecting system is needed. DDR can meet the requirements, so it is the artery of memory at present. In this paper, DDR IP core with 64 bit data width is used, it adopted double data rate of DDR and the high-speed buffer specialty of RAM-2port to achieve data transfer and image buffer on two situations which are based on the FPGA exploit board of Cyclone Ⅲ series of Quartus Ⅱ of Altera company, the design of the system on Signal Tap Ⅱ which is a logic analysis tool is debugged and analyzed.%在现代图像采集显示系统中,常常需要用到大容量、高速度的存储器,DDR为当前存储器应用的主流.采用了64 bit数据位宽的DDR IP核利用DDR的双倍数据传输速度的优点并结合了双口RAM的高速缓存特点,基于Ahera公司的Cyclone Ⅲ系列FPGA开发板在两种平台下实现了数据传输和图像缓存,并使用逻辑分析仪Signal TapⅡ对设计进行调试和分析.

  15. Spatial resolution is dependent on image content for SPECT with iterative reconstruction incorporating distance dependent resolution (DDR) correction. (United States)

    Badger, Daniel; Barnden, Leighton


    The aim of this study is to determine the dependence of single photon emission computed tomography (SPECT) spatial resolution on the content of images for iterative reconstruction with distance dependent resolution (DDR) correction. An experiment was performed using a perturbation technique to measure change in resolution of line sources in simple and complex images with iterative reconstruction with increasing iteration. Projections of the line sources were reconstructed alone and again after the addition of projections of a uniform flood or a complex phantom. An alternative experiment used images of a realistic brain phantom and evaluated an effective spatial resolution by matching the images to the digital version of the phantom convolved with 3D Gaussian kernels. The experiments were performed using ordered subset expectation maximisation iterative reconstruction with and without the use of DDR correction. The results show a significant difference in reconstructed resolution between images of line sources depending on the content of the added image. The full width at half maximum of images of a line source reconstructed using DDR correction increased by 20-30 % when the added image was complex. Without DDR this difference was much smaller and disappeared with increasing iteration. Reported SPECT resolution should be taken as indicative only with regard to clinical imaging if the measurement is made using a point or line source alone and an iterative reconstruction algorithm is used.

  16. Leben in mehreren Wirklichkeiten : "Ein Tag im Jahr" – Christa Wolfs Grabgesang auf die DDR umfasst Erinnerung und Mahnung


    Soldat, Hans-Georg


    "Ein einzelner Mensch kann einer Zeit nicht helfen oder sie retten, er kann nur ausdrücken, daß sie untergeht." Christa Wolf zitiert diesen Satz aus Kierkegaards Tagebüchern voller Trauer. In der Tat ist ihr neues Buch "Ein Tag im Jahr" nichts Anderes als ein Grabgesang auf die DDR. Ein fulminantes Memento, was bekanntlich Erinnerung und Mahnung einbegreift.

  17. Mutations in the DDR2 Kinase Gene identify a Novel therapeutic target in squamous cell lung cancer

    NARCIS (Netherlands)

    Hammerman, Peter S.; Sos, Martin L.; Ramos, Alex H.; Xu, Chunxiao; Dutt, Amit; Zhou, Wenjun; Brace, Lear E.; Woods, Brittany A.; Lin, Wenchu; Zhang, Jianming; Deng, Xianming; Lim, Sang Min; Heynck, Stefanie; Peifer, Martin; Simard, Jeffrey R.; Lawrence, Michael S.; Onofrio, Robert C.; Salvesen, Helga B.; Seidel, Danila; Zander, Thomas; Heuckmann, Johannes M.; Soltermann, Alex; Moch, Holger; Koker, Mirjam; Leenders, Frauke; Gabler, Franziska; Querings, Silvia; Ansen, Sascha; Brambilla, Elisabeth; Brambilla, Christian; Lorimier, Philippe; Brustugun, Odd Terje; Helland, Aslaug; Petersen, Iver; Clement, Joachim H.; Groen, Harry; Timens, Wim; Sietsma, Hannie; Stoelben, Erich; Wolf, Juergen; Beer, David G.; Tsao, Ming Sound; Hanna, Megan; Hatton, Charles; Eck, Michael J.; Janne, Pasi A.; Johnson, Bruce E.; Winckler, Wendy; Greulich, Heidi; Bass, Adam J.; Cho, Jeonghee; Rauh, Daniel; Gray, Nathanael S.; Wong, Kwok-Kin; Haura, Eric B.; Thomas, Roman K.; Meyerson, Matthew


    Although genomically targeted therapies have improved outcomes for patients with lung adenocarcinoma, little is known about the genomic alterations that drive squamous cell cancer (SCC) of the lung. Sanger sequencing of the tyrosine kinome identified mutations in the DDR2 kinase gene in 3.8% of lung

  18. Dry development rinse (DDR) process and material for ArF/EUV extension technique toward 1Xnm hp and beyond (United States)

    Shigaki, Shuhei; Onishi, Ryuji; Sakamoto, Rikimaru


    Since the pattern pitch is getting smaller and smaller, the pattern collapse issue has been getting sever problem in the lithography process. Pattern collapse is one of the main reasons for minimizing of process margin at fine pitch by ArF-immersion or EUV lithography. The possible major cause of pattern collapse is the surface tension of the rinsing liquid and the shrinkage of resist pattern's surface. These surface tension or shrinkage are occurred in the spin drying process of the rinsing liquid. The influence of surface tension against very small pitch pattern is particularly severe. One of the most effective solution for this problem is thinning of the resist film thickness, however this strategy is reaching to its limits in terms of substrate etching process anymore. Recently the tri-layer resist process or hard mask processes have been used, but there is a limit to the thinning of resist film and there is no essential solution for this problem. On the other hand, dry development process such a supercritical drying method or DSA patterning by dry etching have been known as an ultimate way to suppress the pattern collapse issue. However, these processes are not applied to the mass production process right now because these have some problems such a defect issue, requirement of the special equipment and so on. We newly developed the novel process and material which can prevent the pattern collapse issue perfectly without using any special equipment. The process is Dry Development Rinse process (DDR process), and the material used in the process is Dry Development Rinse material (DDR material). DDR material is containing the special polymer which can replace the exposed and developed part. And finally, the resist pattern is developed by dry etching process without any pattern collapse issue. In this paper, we will discuss the approach for preventing the pattern collapse issue in ArF and EUV lithography process, and propose DDR process and DDR material as the

  19. Lovastatin prevents cisplatin-induced activation of pro-apoptotic DNA damage response (DDR) of renal tubular epithelial cells. (United States)

    Krüger, Katharina; Ziegler, Verena; Hartmann, Christina; Henninger, Christian; Thomale, Jürgen; Schupp, Nicole; Fritz, Gerhard


    The platinating agent cisplatin (CisPt) is commonly used in the therapy of various types of solid tumors. The anticancer efficacy of CisPt largely depends on the formation of bivalent DNA intrastrand crosslinks, which stimulate mechanisms of the DNA damage response (DDR), thereby triggering checkpoint activation, gene expression and cell death. The clinically most relevant adverse effect associated with CisPt treatment is nephrotoxicity that results from damage to renal tubular epithelial cells. Here, we addressed the question whether the HMG-CoA-reductase inhibitor lovastatin affects the DDR of renal cells by employing rat renal proximal tubular epithelial (NRK-52E) cells as in vitro model. The data show that lovastatin has extensive inhibitory effects on CisPt-stimulated DDR of NRK-52E cells as reflected on the levels of phosphorylated ATM, Chk1, Chk2, p53 and Kap1. Mitigation of CisPt-induced DDR by lovastatin was independent of the formation of DNA damage as demonstrated by (i) the analysis of Pt-(GpG) intrastrand crosslink formation by Southwestern blot analyses and (ii) the generation of DNA strand breaks as analyzed on the level of nuclear γH2AX foci and employing the alkaline comet assay. Lovastatin protected NRK-52E cells from the cytotoxicity of high CisPt doses as shown by measuring cell viability, cellular impedance and flow cytometry-based analyses of cell death. Importantly, the statin also reduced the level of kidney DNA damage and apoptosis triggered by CisPt treatment of mice. The data show that the lipid-lowering drug lovastatin extensively counteracts pro-apoptotic signal mechanisms of the DDR of tubular epithelial cells following CisPt injury.

  20. DDR complex facilitates global association of RNA polymerase V to promoters and evolutionarily young transposons. (United States)

    Zhong, Xuehua; Hale, Christopher J; Law, Julie A; Johnson, Lianna M; Feng, Suhua; Tu, Andy; Jacobsen, Steven E


    The plant-specific DNA-dependent RNA polymerase V (Pol V) evolved from Pol II to function in an RNA-directed DNA methylation pathway. Here, we have identified targets of Pol V in Arabidopsis thaliana on a genome-wide scale using ChIP-seq of NRPE1, the largest catalytic subunit of Pol V. We found that Pol V is enriched at promoters and evolutionarily recent transposons. This localization pattern is highly correlated with Pol V-dependent DNA methylation and small RNA accumulation. We also show that genome-wide chromatin association of Pol V is dependent on all members of a putative chromatin-remodeling complex termed DDR. Our study presents a genome-wide view of Pol V occupancy and sheds light on the mechanistic basis of Pol V localization. Furthermore, these findings suggest a role for Pol V and RNA-directed DNA methylation in genome surveillance and in responding to genome evolution.

  1. Compounds from Polyphaga plancyi and their inhibitory activities against JAK3 and DDR1 kinases. (United States)

    Zhu, Hong-Jie; Yan, Yong-Ming; Tu, Zheng-Chao; Luo, Jin-Feng; Liang, Rui; Yang, Tong-Hua; Cheng, Yong-Xian; Wang, Shu-Mei


    Plancyamides A (1) and B (3), plancypyrazine A (2), and plancyols A (4) and B (5), five new compounds (1-5), and three known ones (6-8), were isolated from the whole bodies of Polyphaga plancyi Bolivar. Their structures were elucidated by a combination of spectroscopic analyses including 1D and 2D NMR, and HRESIMS. Among them, compound 3 is racemic, chiral HPLC separation afforded its respective enantiomers. The absolute configuration of 1 was assigned by computational methods. Biological evaluation of all the compounds with exception of 7 and 8 discloses that compounds 2 and 4 could inhibit JAK3 kinase with IC50 values of 12.6 and 5.0μM, respectively. In addition, compound 4 exhibit inhibitory activity towards DDR1 kinase with IC50 value of 4.87μM.

  2. Weibliche Arbeitserfahrungen in der DDR Women’s Work experiences in the GDR

    Directory of Open Access Journals (Sweden)

    Albrecht Wiesener


    Full Text Available Annegret Schüle kommt in ihrer Untersuchung zu dem Ergebnis, dass die DDR-Diktatur das Leben von Frauen mehr veränderte als das der Männer. Ihre auf Interviews basierende Untersuchung fokussiert den (Berufs-Alltag von Frauen in der Leipziger Baumwollspinnerei. Anhand der drei Kategorien „Generation“, „Frauenarbeit“ und „Vergemeinschaftung im Betrieb“ diskutiert sie die geführten Interviews , die Förderung weiblicher Erwerbstätiger einerseits und das Negativimage des Textilbetriebs andererseits. Die Autorin legt eine überzeugende Studie zur Erfahrungsgeschichte weiblicher Industriearbeit vor und zeigt am konkreten Beispiel, wie die DDR-Gesellschaft in einer von Frauen getragenen familiarisierten Betriebskultur nicht aufgebrochen, sondern in einer eigentümlichen Verbindung von Geborgenheit und Unterordnung reproduziert wurde.Schüle argues that the Eastern German dictatorship had a greater impact on the lives of women than on those of their male counterparts. Her research, based on interviews with female workers in a in a cotton-spinning factory in Leipzig, portrays women’s everyday-life and work, and offers a convincing study of the experience of female industrial workers. Using the three categories “cohort,” “women’s work,” and a discourse of “factory-as-community,” Schüle discusses her interviews with respect to the promotion of female textile workers on the one hand and the negative stereotypes associated with working in the textile industry on the other hand. Using concrete examples, Schüle demonstrates how a factory organised by women did not undermine the patriarchal frame in which it was embedded but how existing power differentials were reproduced as part of a discourse of family, security, and subordination.

  3. Transcriptome analysis reveals an unexpected role of a collagen tyrosine kinase receptor gene, Ddr2, as a regulator of ovarian function. (United States)

    Matsumura, Hirokazu; Kano, Kiyoshi; Marín de Evsikova, Caralina; Young, James A; Nishina, Patsy M; Naggert, Jürgen K; Naito, Kunihiko


    Mice homozygous for the smallie (slie) mutation lack a collagen receptor, discoidin domain receptor 2 (DDR2), and are dwarfed and infertile due to peripheral dysregulation of the endocrine system of unknown etiology. We used a systems biology approach to identify biological networks affected by Ddr2(slie/slie) mutation in ovaries using microarray analysis and validate findings using molecular, cellular, and functional biological assays. Transcriptome analysis indicated several altered gene categories in Ddr2(slie/slie) mutants, including gonadal development, ovulation, antiapoptosis, and steroid hormones. Subsequent biological experiments confirmed the transcriptome analysis predictions. For instance, a significant increase of TUNEL-positive follicles was found in Ddr2(slie/slie) mutants vs. wild type, which confirm the transcriptome prediction for decreased chromatin maintenance and antiapoptosis. Decreases in gene expression were confirmed by RT-PCR and/or qPCR; luteinizing hormone receptor and prostaglandin type E and F receptors in Ddr2(slie/slie) mutants, compared with wild type, confirm hormonal signaling pathways involved in ovulation. Furthermore, deficiencies in immunohistochemistry for DDR2 and luteinizing hormone receptor in the somatic cells, but not the oocytes, of Ddr2(slie/slie) mutant ovaries suggest against an intrinsic defect in germ cells. Indeed, Ddr2(slie/slie) mutants ovulated significantly fewer oocytes; their oocytes were competent to complete meiosis and fertilization in vitro. Taken together, our convergent data signify DDR2 as a novel critical player in ovarian function, which acts upon classical endocrine pathways in somatic, rather than germline, cells.

  4. Spatial compatibility and affordance compatibility in patients with chronic schizophrenia. (United States)

    Kume, Yu; Sato, Fumiyasu; Hiraoka, Yuya; Suzuki, Shingo; Niyama, Yoshitsugu


    A deterioration in information-processing performance is commonly recognized in patients with chronic schizophrenia. Although the enhancement of cognitive skills in patients with schizophrenia is important, the types of external stimuli that influence performance have not received much attention. The aim of present study was to clarify the effects of spatial and affordance compatibility in patients with schizophrenia, compared with those in healthy people. The subjects (25 patients with schizophrenia and 25 healthy controls) participated in two experiment examining the effects of the spatial location of stimuli and the action-relevance of objects. The results showed that the effect of spatial compatibility was similar in both the patients and the controls, whereas the influence of action-relevant objects was not highlighted in either patients with chronic schizophrenia or healthy controls. These findings provide important evidence of a normal spatial compatibility effect in patients with chronic schizophrenia. However, further research examining the affordance compatibility effect is needed, taking into consideration the symptomatology and the severity of the social functioning level in patients with schizophrenia.

  5. Atuarfitsialak: Greenland's Cultural Compatible Reform (United States)

    Wyatt, Tasha R.


    In 2002, Greenlandic reform leaders launched a comprehensive, nation-wide reform to create culturally compatible education. Greenland's reform work spans the entire educational system and includes preschool through higher education. To assist their efforts, reform leaders adopted the Standards for Effective Pedagogy developed at the Center for…

  6. Electromagnetic compatibility in power electronics

    CERN Document Server

    Costa , François; Revol , Bertrand


    Scientists largely attribute the recent deterioration of the electromagnetic environment to power electronics. This realization has spurred the study of methodical approaches to electromagnetic compatibility designs as explored in this text. The book addresses major challenges, such as handling numerous parameters vital to predicting electro magnetic effects and achieving compliance with line-harmonics norms, while proposing potential solutions.

  7. Genetic analysis identifies DDR2 as a novel gene affecting bone mineral density and osteoporotic fractures in Chinese population.

    Directory of Open Access Journals (Sweden)

    Yan Guo

    Full Text Available DDR2 gene, playing an essential role in regulating osteoblast differentiation and chondrocyte maturation, may influence bone mineral density (BMD and osteoporosis, but the genetic variations actually leading to the association remain to be elucidated. Therefore, the aim of this study was to investigate whether the genetic variants in DDR2 are associated with BMD and fracture risk. This study was performed in three samples from two ethnicities, including 1,300 Chinese Han subjects, 700 Chinese Han subjects (350 with osteoporotic hip fractures and 350 healthy controls and 2,286 US white subjects. Twenty-eight SNPs in DDR2 were genotyped and tested for associations with hip BMD and fractures. We identified 3 SNPs in DDR2 significantly associated with hip BMD in the Chinese population after multiple testing adjustments, which were rs7521233 (P = 1.06×10-4, β: -0.018 for allele C, rs7553831 (P = 1.30×10-4, β: -0.018 for allele T, and rs6697469 (P = 1.59×10-3, β: -0.015 for allele C, separately. These three SNPs were in high linkage disequilibrium. Haplotype analyses detected two significantly associated haplotypes, including one haplotype in block 2 (P = 9.54×10-4, β: -0.016 where these three SNPs located. SNP rs6697469 was also associated with hip fractures (P = 0.043, OR: 1.42 in the Chinese population. The effect on fracture risk was consistent with its association with lower BMD. However, in the white population, we didn't observe significant associations with hip BMD. eQTL analyses revealed that SNPs associated with BMD also affected DDR2 mRNA expression levels in Chinese. Our findings, together with the prior biological evidence, suggest that DDR2 could be a new candidate for osteoporosis in Chinese population. Our results also reveal an ethnic difference, which highlights the need for further genetic studies in each ethnic group.

  8. Genetic analysis identifies DDR2 as a novel gene affecting bone mineral density and osteoporotic fractures in Chinese population. (United States)

    Guo, Yan; Yang, Tie-Lin; Dong, Shan-Shan; Yan, Han; Hao, Ruo-Han; Chen, Xiao-Feng; Chen, Jia-Bin; Tian, Qing; Li, Jian; Shen, Hui; Deng, Hong-Wen


    DDR2 gene, playing an essential role in regulating osteoblast differentiation and chondrocyte maturation, may influence bone mineral density (BMD) and osteoporosis, but the genetic variations actually leading to the association remain to be elucidated. Therefore, the aim of this study was to investigate whether the genetic variants in DDR2 are associated with BMD and fracture risk. This study was performed in three samples from two ethnicities, including 1,300 Chinese Han subjects, 700 Chinese Han subjects (350 with osteoporotic hip fractures and 350 healthy controls) and 2,286 US white subjects. Twenty-eight SNPs in DDR2 were genotyped and tested for associations with hip BMD and fractures. We identified 3 SNPs in DDR2 significantly associated with hip BMD in the Chinese population after multiple testing adjustments, which were rs7521233 (P = 1.06×10-4, β: -0.018 for allele C), rs7553831 (P = 1.30×10-4, β: -0.018 for allele T), and rs6697469 (P = 1.59×10-3, β: -0.015 for allele C), separately. These three SNPs were in high linkage disequilibrium. Haplotype analyses detected two significantly associated haplotypes, including one haplotype in block 2 (P = 9.54×10-4, β: -0.016) where these three SNPs located. SNP rs6697469 was also associated with hip fractures (P = 0.043, OR: 1.42) in the Chinese population. The effect on fracture risk was consistent with its association with lower BMD. However, in the white population, we didn't observe significant associations with hip BMD. eQTL analyses revealed that SNPs associated with BMD also affected DDR2 mRNA expression levels in Chinese. Our findings, together with the prior biological evidence, suggest that DDR2 could be a new candidate for osteoporosis in Chinese population. Our results also reveal an ethnic difference, which highlights the need for further genetic studies in each ethnic group.

  9. 三款主流2GB DDR2 800内存——价格便宜量又足

    Institute of Scientific and Technical Information of China (English)


    今年年初2GB DDR2 800内存的价格还在400元上下,如今已经跌去了100元左右,玩家使用2GB DDR2 800内存的成本已经非常低廉。不少玩家甚至在装机时一次性到位,直接采用两根2GB DDR2 800内存,达到了32位Windows操作系统的上限,让内存容量不再成为系统的瓶颈。下面我们为大家推荐三款中高端2GB DDR2 800内存。

  10. Phosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer mutants. (United States)

    Iwai, Leo K; Payne, Leo S; Luczynski, Maciej T; Chang, Francis; Xu, Huifang; Clinton, Ryan W; Paul, Angela; Esposito, Edward A; Gridley, Scott; Leitinger, Birgit; Naegle, Kristen M; Huang, Paul H


    Collagen is an important extracellular matrix component that directs many fundamental cellular processes including differentiation, proliferation and motility. The signalling networks driving these processes are propagated by collagen receptors such as the β1 integrins and the DDRs (discoidin domain receptors). To gain an insight into the molecular mechanisms of collagen receptor signalling, we have performed a quantitative analysis of the phosphorylation networks downstream of collagen activation of integrins and DDR2. Temporal analysis over seven time points identified 424 phosphorylated proteins. Distinct DDR2 tyrosine phosphorylation sites displayed unique temporal activation profiles in agreement with in vitro kinase data. Multiple clustering analysis of the phosphoproteomic data revealed several DDR2 candidate downstream signalling nodes, including SHP-2 (Src homology 2 domain-containing protein tyrosine phosphatase 2), NCK1 (non-catalytic region of tyrosine kinase adaptor protein 1), LYN, SHIP-2 [SH2 (Src homology 2)-domain-containing inositol phosphatase 2], PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2α) and PLCL2 (phospholipase C-like 2). Biochemical validation showed that SHP-2 tyrosine phosphorylation is dependent on DDR2 kinase activity. Targeted proteomic profiling of a panel of lung SCC (squamous cell carcinoma) DDR2 mutants demonstrated that SHP-2 is tyrosine-phosphorylated by the L63V and G505S mutants. In contrast, the I638F kinase domain mutant exhibited diminished DDR2 and SHP-2 tyrosine phosphorylation levels which have an inverse relationship with clonogenic potential. Taken together, the results of the present study indicate that SHP-2 is a key signalling node downstream of the DDR2 receptor which may have therapeutic implications in a subset of DDR2 mutations recently uncovered in genome-wide lung SCC sequencing screens.

  11. DDR2 inhibition reduces migration and invasion of murine metastatic melanoma cells by suppressing MMP2/9 expression through ERK/NF-κB pathway. (United States)

    Poudel, Barun; Lee, Young-Mi; Kim, Dae-Ki


    Metastatic melanoma is one of the most deadly and evasive cancers. Collagen I in the extracellular matrix promotes the migration and invasion of tumor cells through the production of matrix metalloproteinase (MMP) 2 and 9. Discoidin domain receptor (DDR) 2 is a collagen receptor that is implicated in several cancer types including breast and prostate cancers. However, the role of DDR2 in the migration and invasion of murine melanoma cells is less studied. In the present study, we investigated the effects and underlying mechanisms of DDR2 in migration and invasion of B16BL6 melanoma cells in response to collagen I. Results demonstrated that DDR2 is expressed and is phosphorylated by collagen I in the cells. Upon down-regulation of DDR2 using small-interfering RNA (siRNA) approach, both of the cell migratory and invasive phenotypes were significantly attenuated when compared with the control cells. This effect was mediated via suppression of MMP2/9 upon DDR2 inhibition. Furthermore, inhibition of DDR2 by specific siRNA markedly reduced the activation of extracellular regulated kinase (ERK) 1 and 2 and nuclear factor of kappa B (NF-κB) in the cells when compared with the control cells. Overall, these data demonstrated that DDR2 siRNA-mediated suppression of ERK1/2 and NF-κB could down-regulate the expressions of MMP2/9 in response to collagen I to reduce the migratory and invasive phenotypes of the cells.

  12. Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients. (United States)

    Ali, Bassam R; Xu, Huifang; Akawi, Nadia A; John, Anne; Karuvantevida, Noushad S; Langer, Ruth; Al-Gazali, Lihadh; Leitinger, Birgit


    Spondylo-meta-epiphyseal dysplasia (SMED) with short limbs and abnormal calcifications (SMED-SL) is a rare, autosomal recessive human growth disorder, characterized by disproportionate short stature, short limbs, short broad fingers, abnormal metaphyses and epiphyses, platyspondyly and premature calcifications. Recently, three missense mutations and one splice-site mutation in the DDR2 gene were identified as causative genetic defects for SMED-SL, but the underlying cellular and biochemical mechanisms were not explored. Here we report a novel DDR2 missense mutation, c.337G>A (p.E113K), that causes SMED-SL in two siblings in the United Arab Emirates. Another DDR2 missense mutation, c.2254C>T (p.R752C), matching one of the previously reported SMED-SL mutations, was found in a second affected family. DDR2 is a plasma membrane receptor tyrosine kinase that functions as a collagen receptor. We expressed DDR2 constructs with the identified point mutations in human cell lines and evaluated their localization and functional properties. We found that all SMED-SL missense mutants were defective in collagen-induced receptor activation and that the three previously reported mutants (p.T713I, p.I726R and p.R752C) were retained in the endoplasmic reticulum. The novel mutant (p.E113K), in contrast, trafficked normally, like wild-type DDR2, but failed to bind collagen. This finding is in agreement with our recent structural data identifying Glu113 as an important amino acid in the DDR2 ligand-binding site. Our data thus demonstrate that SMED-SL can result from at least two different loss-of-function mechanisms: namely defects in DDR2 targeting to the plasma membrane or the loss of its ligand-binding activity.

  13. Expression of discoidin domain receptor 2 (DDR2) extracellular domain in pichia pastoris and functional analysis in synovial fibroblasts and NIT3T3 cells. (United States)

    Zhang, Wei; Ding, Tianbing; Zhang, Jian; Su, Jin; Li, Fuyang; Liu, Xinping; Ma, Wenyu; Yao, Libo


    Discoidin domain receptor 2 (DDR2) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. To investigate the roles of DDR2 in destruction of cartilage in rheumatoid arthritis (RA) and tumor metastasis, we tried to express extracellular domain of DDR2 fused with a His tag to increase protein solubility and facilitate purification (without signal peptide and transmembrane domain, designated DR) in Pichia pastoris, purify the expressed protein, and characterize its function, for purpose of future application as a specific DDR2 antagonist. Two clones of relative high expression of His-DR were obtained. After purification by a Ni-NTA (nitric-tri-acetic acid) chromatographic column, soluble fused His-DR over 90% purity were obtained. Competitive binding inhibition assay demonstrated that expressed His-DR could block the binding of DDR2 and natural DDR2 receptors on NIT3T3 and synovial cell surfaces. Results of RT-PCR, Western blotting, and gelatinase zymography showed that His-DR was capable of inhibiting MMP-1 and MMP-2 secretion from NIT3T3 cells and RA synoviocytes stimulated by collagen II. For MMP-1, the inhibitory effect was displayed at the levels of mRNA and protein, whereas for MMP-2 it was demonstrated at the level of protein physiological activity. All these findings suggested that the fused expressed His-DR inhibited the activity of natural DDR2, and relevant MMP-1 and MMP-2 expression in synoviocytes and NIH3T3 cells provoked by collagen II.

  14. Insurgency, militias and DDR as part of security sector reconstruction in Iraq: how not to do it. (United States)

    Ozerdem, Alpaslan


    One of the most demanding challenges since the occupation of Iraq in 2003 has been the establishment of security and stability. The continuation of violence by myriad armed groups is yet to be tackled as part of a comprehensive security sector reform initiative in which effective disarmament, demobilisation and reintegration (DDR) of former combatants will constitute a litmus test of success or failure. In Iraq, much insurgent and militia activity is shadowy and difficult to trace. However, those involved can be divided into two main categories: insurgent groups; and Shi'a militias. In a highly complex and insecure environment such as this, resulting from the presence of many armed groups with varying agendas and objectives, the conduct of a DDR process will be an extremely sensitive and testing task both for Iraq and the international community. Appropriate preparation for such a process is clearly an imperative for the generation of peace in the country.

  15. Collagen advanced glycation inhibits its Discoidin Domain Receptor 2 (DDR2)-mediated induction of lysyl oxidase in osteoblasts. (United States)

    Khosravi, Roozbeh; Sodek, Katharine L; Faibish, Michael; Trackman, Philip C


    Diabetes increases the risk of bone fracture. Organic and inorganic bone extracellular matrix components determine bone strength. Previous studies indicate that in diabetes, glycation of collagen causes abnormal arrangements of collagen molecules and fragile bones. Diabetic bone fragility is additionally attributed to reduced levels of lysyl oxidase enzyme-dependent collagen cross-links. The mechanism underlying the presence of lower enzymatic collagen cross-links in diabetic bone has not been directly investigated. Here we determine in primary osteoblast cultures the regulation of lysyl oxidase protein by type I collagen and collagen modified by carboxymethylation (CML-collagen), a form of advanced glycation endproducts. Data indicate that non-glycated collagen up-regulates lysyl oxidase levels both in primary non-differentiated and in differentiating mouse and rat osteoblast cultures, while CML-collagen fails to regulate lysyl oxidase in these cells. Collagen binding to Discoidin Domain Receptor-2 (DDR2) mediates lysyl oxidase increases, determined in DDR2 shRNA knockdown studies. DDR2 binding and activation were disrupted by collagen glycation, pointing to a mechanism for the diminished levels of lysyl oxidase and consequently low lysyl oxidase-derived cross-links in diabetic bone. Our studies indicate that collagen-integrin interactions may not play a major role in up-regulating lysyl oxidase. Furthermore, non-collagenous ligands for the receptor for advanced glycation end products (RAGE) failed to alter lysyl oxidase levels. Taken together with published studies a new understanding emerges in which diabetes- and age-dependent inhibition of normal collagen-stimulated DDR2- and integrin-signaling, and independent advanced glycation-stimulated RAGE-signaling, each contributes to different aspects of diabetic osteopenia.

  16. Assessment of DDR2, BRAF, EGFR and KRAS mutations as therapeutic targets in non-adenocarcinoma lung cancer patients. (United States)

    Yashima, Hideaki; Shimizu, Kimihiro; Araki, Takuya; Aomori, Tohru; Ohtaki, Yoichi; Nagashima, Toshiteru; Enokida, Yasuaki; Atsumi, Jun; Nakamura, Tomonori; Takeyoshi, Izumi; Yamamoto, Koujirou


    Molecular-targeted therapy has not been established in non-adenocarcinoma lung cancer (non-AdLC), as no targets that affect the clinical efficacy of molecular-targeted drugs have yet been identified. In this study, we investigated the frequency of genetic variations in discoidin domain receptor 2 (DDR2), v-raf murine sarcoma viral oncogene homolog B1 (BRAF), epidermal growth factor receptor (EGFR) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) in non-AdLC patients, in order to evaluate the possibility of genetic mutations in these genes being used as therapeutic targets for the treatment of patients with non-AdLC. For this purpose, we enrolled 150 non-AdLC patients who had undergone surgery at the Gunma University Hospital between December, 2003 and December, 2012. Genetic mutations in the EGFR, KRAS, DDR2 and BRAF genes were detected by a sequencing method or probe assay using DNA derived from cancer tissues. No somatic mutations in DDR2 or BRAF were detected in non-AdLC patients. Conversely, genetic mutations in EGFR exon 19 were found in 3 squamous cell carcinoma (SCC) and 3 adenosquamous carcinoma patients, whereas KRAS codon 12 mutations were also found in 3 SCC patients and 1 large-cell neuroendocrine carcinoma patient. EGFR and KRAS mutations were mutually exclusive. This study indicated that, although DDR2 and BRAF mutations may only rarely be used as therapeutic targets, EGFR and KRAS mutations may represent candidate therapeutic targets, at least in the non-AdLC patients investigated.

  17. DDR的终结者——12款主流DDR2内存横向评测

    Institute of Scientific and Technical Information of China (English)



  18. Physics-compatible numerical methods


    Barry, Koren; Abgrall, Remi; Pavel, Bochev; Jason, Frank; Blair, Perrot


    International audience; Physics-compatible numerical methods are methods that aim to preserve key mathematical and physical properties of continuum physics models in their finite-dimensional algebraic representations. They include methods which preserve properties such as energy, monotonicity, maximum principles, symmetries, and involutions of the continuum models. Examples are mimetic methods for spatial discretizations, variational and geometric integrators, conservative finite-volume and f...

  19. Football and post-war reintegration: exploring the role of sport in DDR processes in Sierra Leone. (United States)

    Dyck, Christopher B


    Growing enthusiasm for 'Sport for development and peace' (SDP) projects around the world has created a much greater interest among critical scholars seeking to interrogate potential gains, extant limitations and challenges of using sport to advance 'development' and 'peace' in Africa. Despite this interest, the role of sport in post-conflict peace building remains poorly understood. Since peace building, as a field of study, lends itself to practical approaches that seek to address underlying sources of violent conflict, it is surprising that it has neglected to take an interest in sport, especially its grassroots models. In Africa, football (soccer) in particular has a strong appeal because of its popularity and ability to mobilise individuals and communities. Through a case study on Sierra Leone, this paper focuses on sports in a particularly prominent post-civil war UN intervention—the disarmament, demobilisation and reintegration (DDR) process—to determine how ex-youth combatants, camp administrators and caregivers perceive the role and significance of sporting activities in interim care centres (ICCS) or DDR camps. It argues that sporting experiences in ddr processes are fruitful microcosms for understanding nuanced forms of violence and healing among youth combatants during their reintegration process.

  20. Diamond Based DDR IMPATTs: Prospects and Potentiality as Millimeter-Wave Source at 94 GHz Atmospheric Window

    Directory of Open Access Journals (Sweden)

    A. Acharyya


    Full Text Available Large-signal simulation is carried out in this paper to investigate the prospects and potentiality of Double-Drift Region (DDR Impact Avalanche Transit Time (IMPATT device based on semiconducting type-IIb diamond as millimeter-wave source operating at 94 GHz atmospheric window frequency. Large-signal simulation method developed by the authors and presented in this paper is based on non-sinusoidal voltage excitation. The simulation is carried out to obtain the large-signal characteristics such as RF power output, DC to RF conversion efficiency etc. of DDR diamond IMPATT device designed to operate at 94 GHz. The results show that the device is capable of delivering a peak RF power output of 7.01 W with 10.18% DC to RF conversion efficiency for a bias current density of 6.0×10^8 A m^-2 and voltage modulation of 60% at 94 GHz; whereas for the same voltage modulation 94 GHz DDR Si IMPATT can deliver only 693.82 mW RF power with 8.74 efficiency for the bias current density of 3.4×10^8 A m^-2.


    Institute of Scientific and Technical Information of China (English)



    In 1930 Szpilrajn proved that any strict partial order can be embedded in a strict linear order.This theorem was later refined by Dushnik and Miller (1941), Hansson (1968), Suzumura (1976),Donaldson and Weymark (1998), Bossert (1999). Particularly Suzumura introduced the important concept of compatible extension of a (crisp) relation. These extension theorems have an important role in welfare economics. In particular Szpilrajn theorem is the main tool for proving a known theorem of Richter that establishes the equivalence between rational and congruous consumers. In 1999 Duggan proved a general extension theorem that contains all these results. In this paper we introduce the notion of compatible extension of a fuzzy relation and we prove an extension theorem for fuzzy relations. Our result generalizes to fuzzy set theory the main part of Duggan's theorem. As applications we obtain fuzzy versions of the theorems of Szpilrajn, Hansson and Suzumura. We also prove that an asymmetric and transitive fuzzy relation has a compatible extension that is total, asymmetric and transitive.Our results can be useful in the theory of fuzzy consumers. We can prove that any rational fuzzyconsumer is congruous, extending to a fuzzy context a part of Richter's theorem. To prove that acongruous fuzzy consumer is rational remains an open problem. A proof of this result can somehowuse a fuzzy version of Szpilrajn theorem.

  2. Multiparty Compatibility for Concurrent Objects

    Directory of Open Access Journals (Sweden)

    Roly Perera


    Full Text Available Objects and actors are communicating state machines, offering and consuming different services at different points in their lifecycle. Two complementary challenges arise when programming such systems. When objects interact, their state machines must be "compatible", so that services are requested only when they are available. Dually, when objects refine other objects, their state machines must be "compliant", so that services are honoured whenever they are promised. In this paper we show how the idea of multiparty compatibility from the session types literature can be applied to both of these problems. We present an untyped language in which concurrent objects are checked automatically for compatibility and compliance. For simple objects, checking can be exhaustive and has the feel of a type system. More complex objects can be partially validated via test cases, leading to a methodology closer to continuous testing. Our proof-of-concept implementation is limited in some important respects, but demonstrates the potential value of the approach and the relationship to existing software development practices.

  3. [Compatibility determinations Squaw Creek National Wildlife Refuge (United States)

    US Fish and Wildlife Service, Department of the Interior — This document provides two compatibility determinations; one stated that the proposed agricultural practices (row crop farming) are compatible with Refuge...

  4. DDR2 VS. DDR两代内存“全面开战”!:“吐故纳新”,还是“墨守成规”——DDR2 vs. DDR,内存技术何去何从?

    Institute of Scientific and Technical Information of China (English)




  5. 36 CFR 1193.51 - Compatibility. (United States)


    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Compatibility. 1193.51... BOARD TELECOMMUNICATIONS ACT ACCESSIBILITY GUIDELINES Requirements for Compatibility With Peripheral Devices and Specialized Customer Premises Equipment § 1193.51 Compatibility. When required by subpart B...

  6. 21 CFR 606.151 - Compatibility testing. (United States)


    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Compatibility testing. 606.151 Section 606.151 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... Compatibility testing. Standard operating procedures for compatibility testing shall include the following:...

  7. Constructing Pairs of Compatible Characters

    Institute of Scientific and Technical Information of China (English)

    Mathias Kratzer


    Given a finite group X such that both the conjugacy of elements in X and the length of any conjugacy class in X can be decided/computed efficiently,the first algorithm described in this article constructs a uniquely determined sequence of representatives for all the conjugacy classes of X. In particular, based on this sequence, any two characters of different groups isomorphic to X become comparable against each other which is utilized by a second algorithm designed to construct so-called compatible characters of given finite groups G and H having isomorphic subgroups U ≤ G and V ≤ H, respectively.

  8. Electromagnetic compatibility principles and applications

    CERN Document Server

    Weston, David A


    This totally revised and expanded reference/text provides comprehensive, single-source coverage of the design, problem solving, and specifications of electromagnetic compatibility (EMC) into electrical equipment/systems-including new information on basic theories, applications, evaluations, prediction techniques, and practical diagnostic options for preventing EMI through cost-effective solutions. Offers the most recent guidelines, safety limits, and standards for human exposure to electromagnetic fields! Containing updated data on EMI diagnostic verification measurements, as well as over 900 drawings, photographs, tables, and equations-500 more than the previous edition

  9. Detergent-compatible bacterial amylases. (United States)

    Niyonzima, Francois N; More, Sunil S


    Proteases, lipases, amylases, and cellulases are enzymes used in detergent formulation to improve the detergency. The amylases are specifically supplemented to the detergent to digest starchy stains. Most of the solid and liquid detergents that are currently manufactured contain alkaline enzymes. The advantages of using alkaline enzymes in the detergent formulation are that they aid in removing tough stains and the process is environmentally friendly since they reduce the use of toxic detergent ingredients. Amylases active at low temperature are preferred as the energy consumption gets reduced, and the whole process becomes cost-effective. Most microbial alkaline amylases are used as detergent ingredients. Various reviews report on the production, purification, characterization, and application of amylases in different industry sectors, but there is no specific review on bacterial or fungal alkaline amylases or detergent-compatible amylases. In this mini-review, an overview on the production and property studies of the detergent bacterial amylases is given, and the stability and compatibility of the alkaline bacterial amylases in the presence of the detergents and the detergent components are highlighted.

  10. Settlement-Compatible Lunar Transporation (United States)

    Morgenthaler, G.

    Over the past few years we have published papers in this forum identifying, characterizing and advocating settlement-compatible transportation architectures for Mars. In the present paper, we do the same for the Moon and show evolutionary potentials for growth of lunar architectures into Mars architectures of the types discussed in our previous papers. The essence of a settlement-compatible architecture is that it yields a low recurring transportation cost and that the elements of the architecture are enduring, i.e., fully reusable with lifetimes on the order of Earth-based capital investments. Our previous papers have shown that extension of human habitation to other bodies in our Solar System is probably unaffordable with any other approach. The design of a settlement-compatible architecture begins with Earth launch. In our prior papers, we simply identified the Earth launch option as a fully reusable system with roughly Shuttle (or Atlas 5 or Delta 4 or Sea Launch or Ariane 5) capability, i.e. about 20 metric t. to low Earth orbit and a payload bay of dimensions about 5 m diameter x 15 to 20 m length. This is what the commercial market needs; this is where the traffic demand is; this is approximately the design point for a next-generation (after Shuttle) reusable launch vehicle. We continue in that vein for the present paper. Human mission advocates may argue it isn't big enough; that they need 80 metric t. payload to orbit. We answer that to achieve our cost criteria, there isn't much of a choice, and that the savings in launch cost will far outweigh the added expense for on-orbit assembly. Lunar transportation is considerably less demanding than Mars transportation. The main difference is in trip time. Because lunar trips are short, the crew habitat can be small, a la the Apollo Command Module, and the propulsion system to move it is also small by comparison. We analyze and depict a lunar transportation system based on crew elements adapted from the

  11. Implementing DDR in Settings of Ongoing Conflict: The Organization and Fragmentation of Armed Groups in the Democratic Republic of Congo (DRC

    Directory of Open Access Journals (Sweden)

    Joanne Richards


    Full Text Available Although it is common for armed groups to splinter (or “fragment” during contexts of multi-party civil war, current guidance on Disarmament, Demobilization, and Reintegration (DDR does not address the challenges that arise when recalcitrant fighters, unwilling to report to DDR, break ranks and form new armed groups. This Practice Note addresses this issue, drawing lessons from the multi-party context of the DRC and from the experiences of former members of three armed groups: the Rally for Congolese Democracy-Goma (RCD-Goma, the National Congress for the Defense of the People (CNDP, and the DRC national army (FARDC. While the findings indicate that the fragmentation of armed groups may encourage desertion and subsequent participation in DDR, they also show that active armed groups may monitor DDR programs and track those who demobilize. Remobilization may follow, either as active armed groups target ex-combatants for forced re-recruitment or as ex-combatants remobilize in armed groups of their own choice. Given these dynamics, practitioners in settings of partial peace may find it useful to consider non-traditional methods of DDR such as the use of mobile patrols and mobile disarmament units. The temporary relocation of ex-combatants to safe areas free from armed groups, or to protected transitional assistance camps, may also help to minimize remobilization during the reintegration phase.

  12. The C. elegans Discoidin Domain Receptor DDR-2 Modulates the Met-like RTK-JNK Signaling Pathway in Axon Regeneration. (United States)

    Hisamoto, Naoki; Nagamori, Yuki; Shimizu, Tatsuhiro; Pastuhov, Strahil I; Matsumoto, Kunihiro


    The ability of specific neurons to regenerate their axons after injury is governed by cell-intrinsic regeneration pathways. However, the signaling pathways that orchestrate axon regeneration are not well understood. In Caenorhabditis elegans, initiation of axon regeneration is positively regulated by SVH-2 Met-like growth factor receptor tyrosine kinase (RTK) signaling through the JNK MAPK pathway. Here we show that SVH-4/DDR-2, an RTK containing a discoidin domain that is activated by collagen, and EMB-9 collagen type IV regulate the regeneration of neurons following axon injury. The scaffold protein SHC-1 interacts with both DDR-2 and SVH-2. Furthermore, we demonstrate that overexpression of svh-2 and shc-1 suppresses the delay in axon regeneration observed in ddr-2 mutants, suggesting that DDR-2 functions upstream of SVH-2 and SHC-1. These results suggest that DDR-2 modulates the SVH-2-JNK pathway via SHC-1. We thus identify two different RTK signaling networks that play coordinated roles in the regulation of axonal regeneration.

  13. The C. elegans Discoidin Domain Receptor DDR-2 Modulates the Met-like RTK–JNK Signaling Pathway in Axon Regeneration (United States)

    Shimizu, Tatsuhiro; Matsumoto, Kunihiro


    The ability of specific neurons to regenerate their axons after injury is governed by cell-intrinsic regeneration pathways. However, the signaling pathways that orchestrate axon regeneration are not well understood. In Caenorhabditis elegans, initiation of axon regeneration is positively regulated by SVH-2 Met-like growth factor receptor tyrosine kinase (RTK) signaling through the JNK MAPK pathway. Here we show that SVH-4/DDR-2, an RTK containing a discoidin domain that is activated by collagen, and EMB-9 collagen type IV regulate the regeneration of neurons following axon injury. The scaffold protein SHC-1 interacts with both DDR-2 and SVH-2. Furthermore, we demonstrate that overexpression of svh-2 and shc-1 suppresses the delay in axon regeneration observed in ddr-2 mutants, suggesting that DDR-2 functions upstream of SVH-2 and SHC-1. These results suggest that DDR-2 modulates the SVH-2–JNK pathway via SHC-1. We thus identify two different RTK signaling networks that play coordinated roles in the regulation of axonal regeneration. PMID:27984580

  14. Schriftstellerinnen der DDR und feministisches Bewußtsein im Staatssozialismus GDR Women Authors and Feminist Consciousness During State Socialism

    Directory of Open Access Journals (Sweden)

    Eva Kaufmann


    Full Text Available Seit den 1960er Jahren produzierten Schriftstellerinnen in der DDR wie Christa Wolf, Irmtraud Morgner, Sarah Kirsch, Brigitte Reimann, Charlotte Worgitzky, Lia Pirskawetz, und Maya Wiens eine vielfältige Literatur zu frauenrelevanten Themen. Den Obertitel „The Promised Land“ (das gelobte Land hat Lorna Martens Irmtraud Morgner entlehnt, der Autorin, die sie neben Christa Wolf als wichtigste Zeugin für „feminist writing“ in der DDR betrachtet. In Morgners Roman Leben und Abenteuer der Trobadora Beatriz steht der Begriff „gelobtes Land“ bezogen auf die DDR in einem ironischen Zusammenhang. Mit simplem Jaja oder Neinnein ist diesem „Ort des Wunderbaren“ (Morgner nicht beizukommen. Vergleichbares signalisiert auch das Fragezeichen, das Martens hinter den Begriff „Promised Land“ setzt. Der anspielungsreiche Verweis auf das Land erscheint auch insofern nützlich, als die Eigenart feministischen Schreibens genauer zu fassen ist, wenn über das Land selbst, namentlich seine Frauenpolitik, Auskünfte gegeben werden. Lorna Martens möchte herausfinden, wie Schriftstellerinnen in der DDR feministisches Bewusstsein artikuliert haben, d.h. feministisches Bewusstsein unter den vom Staatssozialismus geschaffenen Bedingungen.From the 1960s on, women writers in the German Democratic Republic (GDR, including Christa Wolf, Irmtraud Morgner, Sarah Kirsch, Brigitte Reimann, Charlotte Worgitzky, Lia Pirskawetz, and Maya Wiens, produced a large body of writing on women’s issues. Martens wants to investigate how these women authors in the GDR have articulated their feminist consciousness under the conditions of state socialism. Martens’ use of the title The Promised Land is an allusion to a book by Irmtraud Morgner, an author whom, along with Christa Wolf, Martens considers one of the most important witnesses of feminist writing in the GDR. In Morgner’s book The Life and Adventures of Troubadour Beatriz the term “promised land” is being

  15. Sensitive methods for detection of the S768R substitution in exon 18 of the DDR2 gene in patients with central nervous system metastases of non-small cell lung cancer. (United States)

    Nicoś, Marcin; Powrózek, Tomasz; Krawczyk, Paweł; Jarosz, Bożena; Pająk, Beata; Sawicki, Marek; Kucharczyk, Krzysztof; Trojanowski, Tomasz; Milanowski, Janusz


    Discoidin death receptor 2 (DDR2) receptor belongs to a DDR family that shows a tyrosine kinase activity. The somatic mutations in DDR2 gene, reported in non-small cell lung cancer (NSCLC), are involved in up-regulation of cells' migration, proliferation and survival. A S768R substitution in DDR2 gene was commonly reported in squamous cell lung carcinoma. Clinical data of patients carrying the DDR2 gene mutation suggest that its presence can be independent of gender and age. The effectiveness of an oral dual-specific (Src and Abl) multikinase inhibitors-dasatinib-was observed in different cell lines and in some NSCLC patients with identified DDR2 mutation. In the present study, we have used three molecular methods (ASP-real-time PCR, ASP-DNA-FLA PCR and direct sequencing) to detect the DDR2 gene mutation in 143 patients with NSCLC metastases to the central nervous system (CNS). The prevalence of the DDR2 gene mutation was correlated with the occurrence of mutations in the EGFR, KRAS, HER2 and BRAF genes. We identified three patients (2.1% of studied group) with DDR2 mutation. The mutation was observed in two patients with low differentiated squamous cell lung cancer and in one patient with adeno-squamous cell carcinoma (ADSCC). In ADSCC patients, DDR2 mutation coexisted with G12C substitution in KRAS gene. According to the current knowledge, examination of the presence of the DDR2 gene mutation in metastatic lesion is the first such report worldwide. The information, that these driver mutations are present in CNS metastases of NSCLC, could broaden therapeutic choices in such group of patients.

  16. 用于DDR电源及终端的高效率、双通道、±3A同步降压型稳压器符合DDR/DDR2/DDR3标准

    Institute of Scientific and Technical Information of China (English)


    凌力尔特公司推出一款高效率、双通道、单片式、同步降压型开关稳压器LTC3618,该器件能够为DDR/DDR2/DDR3及未来需要供应和吸收电流的标准存储器应用产生电源电压和总线终端电压。第一个降压型稳压器的输出提供了一个高准确度的VDDQ电源,该电源能输送±3A输出。一个内部电阻分压器负责将VTT DDR终端电源和VTTR基准电压设定为等于施加至VDDQIN输入端之电压的一半,并在VTT和VTTR上分别提供了±3A(供应/吸收)和±10mA的输出电流能力。VTT输出可在低至0.5V的电压条件下运作,以支持所有DDR标准。

  17. Role of value compatibility in IT adoption

    DEFF Research Database (Denmark)

    Bunker, Deborah; Kautz, Karlheinz; Nguyen, Anne Luu Thanh


    Compatibility has been recognised as an important element in the adoption of IT innovations in organisations but as a concept it has been generally limited to technical or functional factors. Compatibility is also significant, however, with regard to value compatibility between the organisation......, and the adopted IT innovation. We propose a framework to determine value compatibility analysing the organisation's and information system's structure, practices and culture, and explore the value compatibility of an organisation with its adopted self-service computer-based information system. A case study...... was conducted to determine the congruence of an organisation's value and IT value compatibility. This study found that there was a high correspondence in the organisational structure and practice dimensions; however, there were organisational culture disparities. The cultural disparities reflected the self...

  18. 77 FR 59702 - Promoting U.S. EC Regulatory Compatibility (United States)


    ... Promoting U.S. EC Regulatory Compatibility AGENCY: Office of the United States Trade Representative. ACTION... greater transatlantic regulatory compatibility generally. Concrete ideas on how greater compatibility... and EC invite your views on how to promote greater transatlantic regulatory compatibility...

  19. Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. (United States)

    Hu, Haiqing; Zhao, Xuanzhong; Jin, Zhao; Hou, Mingxing


    Oxidative stress is linked to increased risk of gastric cancer (GC). Recent reports have found that hsa-let-7 g microRNA (miRNA) has properties of anti-tumor and resistance to damages induced by oxidized low-density lipoprotein (ox-LDL). Dysregulation of hsa-let-7 g was present in GC in vivo and in vitro under exogenous stress. However, we didn't know whether there are regulatory mechanisms of hsa-let-7 g in GC under oxidative stress. This study was aimed at investigating the effects of hsa-let-7 g microRNA (miRNA) on GC under oxidative stress. The results showed that H2O2 induced the increase of DNA damage response (DDR) genes (ATM, H2AX and Chk1) and downregulation of hsa-let-7 g in GC cells. Further study confirmed Hsa-let-7 g caused the apoptosis and loss of proliferation in GC cells exposed to H2O2 associated with repression of DDR system. Yet, we found let-7 g didn't target DDR genes (ATM, H2AX and Chk1) directly. In addition, data revealed hsa-let-7 g miRNA increased the sensitivity of GC to X-rays involving in ATM regulation as well according to application of X-rays (another DDR inducer). In conclusion, Hsa-let-7 g miRNA increased the sensitivity of GC to oxidative stress by repression activation of DDR indirectly. Let-7 g improved the effects of X-rays on GC cells involving in DDR regulation as well.

  20. Vacuum Compatible Percussive Dynamic Cone Penetrometer Project (United States)

    National Aeronautics and Space Administration — Honeybee Robotics proposes to develop a vacuum compatible percussive dynamic cone penetrometer (PDCP), for establishing soil bin characteristics, with the ultimate...

  1. A Characterization of P-Compatible Varieties

    Institute of Scientific and Technical Information of China (English)

    Ivan Chajda; Klaus Denecke; Shelly L. Wismath


    P-Compatibility is a hereditary property of identities which generalizes the properties of normality and externality of identitiesChajda characterized the normalization of a variety by an algebraic construction called a choice algebraIn this paper, we generalize this characterization to the least P-compatible variety P(V) determined by a variety V for any partition P using P-choice algebrasWe also study the clone of (strongly) P-compatible n-ary terms of a variety V, and relate identities of this clone to (strongly) P-compatible hyperidentities of the variety V.

  2. 一种DDR信号阻抗匹配的新方法%New method of DDR signal impedance matching

    Institute of Scientific and Technical Information of China (English)



    There are two ways of DDR signal impedance marching:add the series-resistance in the source or add the shunt-resistance in the terminal.The two methods have their advantages and disadvantages.Source matching will increase the PCB plate area.Terminal matching will increase the power.This paper uses the shunt-capacitor to replace the shunt-resistance,which can solve the problem of PCB layout area,and the problem of single board power increased.It is a new method of DDR signal impedance matching.%DDR信号的阻抗匹配一般有两种方法:源端增加串联电阻和终端增加并联电阻。这两种方法各有利弊。其中源端串阻匹配会增加单板PCB的布板面积,终端并联匹配则会增加单板的功耗。本文则采用并联电容来替代并联电阻,这样即可以解决PCB布板面积的问题,也可以解决单板机功耗增加的问题,是DDR信号匹配的一种新方法。

  3. Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 rearrangements. (United States)

    Egan, Jan B; Barrett, Michael T; Champion, Mia D; Middha, Sumit; Lenkiewicz, Elizabeth; Evers, Lisa; Francis, Princy; Schmidt, Jessica; Shi, Chang-Xin; Van Wier, Scott; Badar, Sandra; Ahmann, Gregory; Kortuem, K Martin; Boczek, Nicole J; Fonseca, Rafael; Craig, David W; Carpten, John D; Borad, Mitesh J; Stewart, A Keith


    Liposarcoma is the most common soft tissue sarcoma, but little is known about the genomic basis of this disease. Given the low cell content of this tumor type, we utilized flow cytometry to isolate the diploid normal and aneuploid tumor populations from a well-differentiated liposarcoma prior to array comparative genomic hybridization and whole genome sequencing. This work revealed massive highly focal amplifications throughout the aneuploid tumor genome including MDM2, a gene that has previously been found to be amplified in well-differentiated liposarcoma. Structural analysis revealed massive rearrangement of chromosome 12 and 11 gene fusions, some of which may be part of double minute chromosomes commonly present in well-differentiated liposarcoma. We identified a hotspot of genomic instability localized to a region of chromosome 12 that includes a highly conserved, putative L1 retrotransposon element, LOC100507498 which resides within a gene cluster (NAV3, SYT1, PAWR) where 6 of the 11 fusion events occurred. Interestingly, a potential gene fusion was also identified in amplified DDR2, which is a potential therapeutic target of kinase inhibitors such as dastinib, that are not routinely used in the treatment of patients with liposarcoma. Furthermore, 7 somatic, damaging single nucleotide variants have also been identified, including D125N in the PTPRQ protein. In conclusion, this work is the first to report the entire genome of a well-differentiated liposarcoma with novel chromosomal rearrangements associated with amplification of therapeutically targetable genes such as MDM2 and DDR2.

  4. Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 rearrangements.

    Directory of Open Access Journals (Sweden)

    Jan B Egan

    Full Text Available Liposarcoma is the most common soft tissue sarcoma, but little is known about the genomic basis of this disease. Given the low cell content of this tumor type, we utilized flow cytometry to isolate the diploid normal and aneuploid tumor populations from a well-differentiated liposarcoma prior to array comparative genomic hybridization and whole genome sequencing. This work revealed massive highly focal amplifications throughout the aneuploid tumor genome including MDM2, a gene that has previously been found to be amplified in well-differentiated liposarcoma. Structural analysis revealed massive rearrangement of chromosome 12 and 11 gene fusions, some of which may be part of double minute chromosomes commonly present in well-differentiated liposarcoma. We identified a hotspot of genomic instability localized to a region of chromosome 12 that includes a highly conserved, putative L1 retrotransposon element, LOC100507498 which resides within a gene cluster (NAV3, SYT1, PAWR where 6 of the 11 fusion events occurred. Interestingly, a potential gene fusion was also identified in amplified DDR2, which is a potential therapeutic target of kinase inhibitors such as dastinib, that are not routinely used in the treatment of patients with liposarcoma. Furthermore, 7 somatic, damaging single nucleotide variants have also been identified, including D125N in the PTPRQ protein. In conclusion, this work is the first to report the entire genome of a well-differentiated liposarcoma with novel chromosomal rearrangements associated with amplification of therapeutically targetable genes such as MDM2 and DDR2.

  5. Tone compatibility between HDR displays (United States)

    Bist, Cambodge; Cozot, Rémi; Madec, Gérard; Ducloux, Xavier


    High Dynamic Range (HDR) is the latest trend in television technology and we expect an in ux of HDR capable consumer TVs in the market. Initial HDR consumer displays will operate on a peak brightness of about 500-1000 nits while in the coming years display peak brightness is expected to go beyond 1000 nits. However, professionally graded HDR content can range from 1000 to 4000 nits. As with Standard Dynamic Range (SDR) content, we can expect HDR content to be available in variety of lighting styles such as low key, medium key and high key video. This raises concerns over tone-compatibility between HDR displays especially when adapting to various lighting styles. It is expected that dynamic range adaptation between HDR displays uses similar techniques as found with tone mapping and tone expansion operators. In this paper, we survey simple tone mapping methods of 4000 nits color-graded HDR content for 1000 nits HDR displays. We also investigate tone expansion strategies when HDR content graded in 1000 nits is displayed on 4000 nits HDR monitors. We conclude that the best tone reproduction technique between HDR displays strongly depends on the lighting style of the content.

  6. New Commitment Options: Compatibility with Emissions Trading

    Energy Technology Data Exchange (ETDEWEB)



    This paper considers different options for quantitative greenhouse gas emission commitments from the standpoint of their technical compatibility with emissions trading. These are dynamic targets, binding targets with price caps, non-binding targets, sector-wide targets/mechanisms, action targets, allowances and endowments, and long-term permits. This paper considers these options from the standpoint of their compatibility with emissions trading.

  7. 40 CFR 280.32 - Compatibility. (United States)


    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Compatibility. 280.32 Section 280.32 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) TECHNICAL...) General Operating Requirements § 280.32 Compatibility. Owners and operators must use an UST system made...

  8. Common Fixed Points for Weakly Compatible Maps

    Indian Academy of Sciences (India)

    Renu Chugh; Sanjay Kumar


    The purpose of this paper is to prove a common fixed point theorem, from the class of compatible continuous maps to a larger class of maps having weakly compatible maps without appeal to continuity, which generalized the results of Jungck [3], Fisher [1], Kang and Kim [8], Jachymski [2], and Rhoades [9].

  9. Is Religious Education Compatible with Science Education? (United States)

    Mahner, Martin; Bunge, Mario


    Addresses the problem of the compatibility of science and religion, and its bearing on science and religious education, challenges the popular view that science and religion are compatible or complementary. Discusses differences at the doctrinal, metaphysical, methodological, and attitudinal levels. Argues that religious education should be kept…

  10. Tank Farm Waste Transfer Compatibility Program

    Energy Technology Data Exchange (ETDEWEB)

    FOWLER, K.D.


    The compatibility program described in this document formalizes the process for determining waste compatibility. The primary goal of the program is to ensure that sufficient controls are in place to prevent the formation of incompatible mixtures during future operations. The process described involves characterizing waste, comparing characteristics with criteria, resolving potential incompatibilities and documenting the process.

  11. A novel Dance Dance Revolution (DDR) system for in-home training of stepping ability: basic parameters of system use by older adults.

    NARCIS (Netherlands)

    Smith, S.T.; Sherrington, C.; Studenski, S.A.; Schoene, D.; Lord, S.R.


    OBJECTIVE: This series of studies was conducted to develop and establish characteristics of exercise videogame play in older adults. The videogame was a modified version of the popular Dance Dance Revolution (DDR; Konomi). METHODS: Participants aged >/=70 were asked to make simple step movements

  12. [Survey of research on acupoints compatibility]. (United States)

    Li, Zhong-Ren


    The research papers that meet the criteria of evidence-based medicine and randomized controlled trial were retrieved in Chinese journals data bases (CNKI knowledge network) from 1992 to 2009. Twenty-five papers indicate that acupoints compatibility rules are closely related to organism regional anatomy, nerve, the blood vessel and the endocrine gland; acupoints compatibility rules produce synergism, inhibit or antagonistic effect that affect the clinical effectiveness. The acupoints compatibility rules based on experimental researches are applied to clinic practice is the key to improve the acupuncture clinical effectiveness.

  13. The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR. (United States)

    Zhou, Liang; Chen, Shuang; Zhang, Yu; Kmieciak, Maciej; Leng, Yun; Li, Lihong; Lin, Hui; Rizzo, Kathryn A; Dumur, Catherine I; Ferreira-Gonzalez, Andrea; Rahmani, Mohamed; Povirk, Lawrence; Chalasani, Sri; Berger, Allison J; Dai, Yun; Grant, Steven


    Two classes of novel agents, NEDD8-activating enzyme (NAE) and histone deacetylase (HDAC) inhibitors, have shown single-agent activity in acute myelogenous leukemia (AML)/myelodysplastic syndrome (MDS). Here we examined mechanisms underlying interactions between the NAE inhibitor pevonedistat (MLN4924) and the approved HDAC inhibitor belinostat in AML/MDS cells. MLN4924/belinostat coadministration synergistically induced AML cell apoptosis with or without p53 deficiency or FLT3-internal tandem duplication (ITD), whereas p53 short hairpin RNA (shRNA) knockdown or enforced FLT3-ITD expression significantly sensitized cells to the regimen. MLN4924 blocked belinostat-induced antiapoptotic gene expression through nuclear factor-κB inactivation. Each agent upregulated Bim, and Bim knockdown significantly attenuated apoptosis. Microarrays revealed distinct DNA damage response (DDR) genetic profiles between individual vs combined MLN4924/belinostat exposure. Whereas belinostat abrogated the MLN4924-activated intra-S checkpoint through Chk1 and Wee1 inhibition/downregulation, cotreatment downregulated multiple homologous recombination and nonhomologous end-joining repair proteins, triggering robust double-stranded breaks, chromatin pulverization, and apoptosis. Consistently, Chk1 or Wee1 shRNA knockdown significantly sensitized AML cells to MLN4924. MLN4924/belinostat displayed activity against primary AML or MDS cells, including those carrying next-generation sequencing-defined poor-prognostic cancer hotspot mutations, and CD34(+)/CD38(-)/CD123(+) populations, but not normal CD34(+) progenitors. Finally, combined treatment markedly reduced tumor burden and significantly prolonged animal survival (P DDR in AML/MDS cells. This strategy warrants further consideration in AML/MDS, particularly in disease with unfavorable genetic aberrations.

  14. NKX3.1 contributes to S phase entry and regulates DNA damage response (DDR) in prostate cancer cell lines. (United States)

    Erbaykent-Tepedelen, Burcu; Ozmen, Besra; Varisli, Lokman; Gonen-Korkmaz, Ceren; Debelec-Butuner, Bilge; Muhammed Syed, Hamid; Yilmazer-Cakmak, Ozgur; Korkmaz, Kemal Sami


    NKX3.1 is an androgen-regulated homeobox gene that encodes a tissue-restricted transcription factor, which plays an important role in the differentiation of the prostate epithelium. Thus, the role of NKX3.1 as a functional topoisomerase I activity enhancer in cell cycle regulation and the DNA damage response (DDR) was explored in prostate cancer cell lines. As an early response to DNA damage following CPT-11 treatment, we found that there was an increase in the γH2AX(S139) foci number and that total phosphorylation levels were reduced in PC-3 cells following ectopic NKX3.1 expression as well as in LNCaP cells following androgen administration. Furthermore, upon drug treatment, the increase in ATM(S1981) phosphorylation was reduced in the presence of NKX3.1 expression, whereas DNA-PKcs expression was increased. Additionally, phosphorylation of CHK2(T68) and NBS1(S343) was abrogated by ectopic NKX3.1 expression, compared with the increasing levels in control PC-3 cells in a time-course experiment. Finally, NKX3.1 expression maintained a high cyclin D1 expression level regardless of drug treatment, while total γH2AX(S139) phosphorylation remained depleted in PC-3, as well as in LNCaP, cells. Thus, we suggest that androgen regulated NKX3.1 maintains an active DDR at the intra S progression and contributes to the chemotherapeutic resistance of prostate cancer cells to DNA damaging compounds.

  15. The deinococcal DdrB protein is involved in an early step of DNA double strand break repair and in plasmid transformation through its single-strand annealing activity. (United States)

    Bouthier de la Tour, Claire; Boisnard, Stéphanie; Norais, Cédric; Toueille, Magali; Bentchikou, Esma; Vannier, Françoise; Cox, Michael M; Sommer, Suzanne; Servant, Pascale


    The Deinococcus radiodurans bacterium exhibits an extreme resistance to ionizing radiation. Here, we investigated the in vivo role of DdrB, a radiation-induced Deinococcus specific protein that was previously shown to exhibit some in vitro properties akin to those of SSB protein from Escherichia coli but also to promote annealing of single stranded DNA. First we report that the deletion of the C-terminal motif of the DdrB protein, which is similar to the SSB C-terminal motif involved in recruitment to DNA of repair proteins, did neither affect cell radioresistance nor DNA binding properties of purified DdrB protein. We show that, in spite of their different quaternary structure, DdrB and SSB occlude the same amount of ssDNA in vitro. We also show that DdrB is recruited early and transiently after irradiation into the nucleoid to form discrete foci. Absence of DdrB increased the lag phase of the extended synthesis-dependent strand annealing (ESDSA) process, affecting neither the rate of DNA synthesis nor the efficiency of fragment reassembly, as indicated by monitoring DNA synthesis and genome reconstitution in cells exposed to a sub-lethal ionizing radiation dose. Moreover, cells devoid of DdrB were affected in the establishment of plasmid DNA during natural transformation, a process that requires pairing of internalized plasmid single stranded DNA fragments, whereas they were proficient in transformation by a chromosomal DNA marker that integrates into the host chromosome through homologous recombination. Our data are consistent with a model in which DdrB participates in an early step of DNA double strand break repair in cells exposed to very high radiation doses. DdrB might facilitate the accurate assembly of the myriad of small fragments generated by extreme radiation exposure through a single strand annealing (SSA) process to generate suitable substrates for subsequent ESDSA-promoted genome reconstitution.

  16. Advanced Microgravity Compatible, Integrated Laundry System Project (United States)

    National Aeronautics and Space Administration — An Advanced Microgravity Compatible, Integrated laundry System (AMCILS) is proposed that uses a two phase water / water vapor system to allow good agitation of...

  17. DOD Offshore Wind Mission Compatibility Assessments (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set represents the results of analyses conducted by the Department of Defense to assess the compatibility of offshore wind development with military assets...

  18. The evolution of polymorphic compatibility molecules

    NARCIS (Netherlands)

    Boer, R.J. de


    Several primitive colonial organisms distinguish self from nonself by means of polymorphic compatibility molecules bearing similarity to the major histocompatibility complex (MHC). The evolution of such polymorphisms is generally explained in terms of resistance to parasites. Ignoring parasites, I d

  19. Electromagnetic theory for electromagnetic compatibility engineers

    CERN Document Server

    Toh, Tze-Chuen


    Engineers and scientists who develop and install electronic devices and circuits need to have a solid understanding of electromagnetic theory and the electromagnetic behavior of devices and circuits. In particular, they must be well-versed in electromagnetic compatibility, which minimizes and controls the side effects of interconnected electric devices. Designed to entice the practical engineer to explore some worthwhile mathematical methods, and to reorient the theoretical scientist to industrial applications, Electromagnetic Theory for Electromagnetic Compatibility Engineers is based on the

  20. Joint SatOPS Compatibility Efforts (United States)

    Smith, Danford


    This slide presentation reviews NASA Goddard Space Flight Center's (GSFC) participation in the interagency cooperation committee, the Joint SatOps Compatibility Committee (JSCC), and the compatible Sat 2 efforts. Part of GSFC's participation in the JSCC is to work with the Goddard Mission Systems Evolution Center (GMSEC) to provides a publish/subscribe framework to enable rapid integration of commercially available satellite control products.

  1. CMOS Compatible Ultra-Compact Modulator

    DEFF Research Database (Denmark)

    Babicheva, Viktoriia; Kinsey, Nathaniel; Naik, Gururaj V.


    A planar layout for an ultra-compact plasmonic modulator is proposed and numerically investigated. Our device utilizes potentially CMOS compatible materials and can achieve 3-dB modulation in just 65nm and insertion loss <1dB at telecommunication wavelengths.......A planar layout for an ultra-compact plasmonic modulator is proposed and numerically investigated. Our device utilizes potentially CMOS compatible materials and can achieve 3-dB modulation in just 65nm and insertion loss

  2. ATCA/AXIe compatible board for fast control and data acquisition in nuclear fusion experiments

    Energy Technology Data Exchange (ETDEWEB)

    Batista, A.J.N., E-mail: [Associacao EURATOM/IST, Instituto de Plasmas e Fusao Nuclear - Laboratorio Associado, Instituto Superior Tecnico - Universidade Tecnica de Lisboa, Lisboa (Portugal); Leong, C.; Bexiga, V. [INESC-ID, Lisboa (Portugal); Rodrigues, A.P.; Combo, A.; Carvalho, B.B.; Fortunato, J.; Correia, M. [Associacao EURATOM/IST, Instituto de Plasmas e Fusao Nuclear - Laboratorio Associado, Instituto Superior Tecnico - Universidade Tecnica de Lisboa, Lisboa (Portugal); Teixeira, J.P.; Teixeira, I.C. [INESC-ID, Lisboa (Portugal); Sousa, J.; Goncalves, B.; Varandas, C.A.F. [Associacao EURATOM/IST, Instituto de Plasmas e Fusao Nuclear - Laboratorio Associado, Instituto Superior Tecnico - Universidade Tecnica de Lisboa, Lisboa (Portugal)


    , Xilinx Virtex 6 FPGA, standard Dual Data Rate (DDR) 3 SODIMM memory, standard CompactFLASH memory card, Intelligent Platform Management Controller (IPMC), two PCI Express x4 (generation 2) ATCA Fabric channels (dual-star topology), eleven Xilinx Aurora x1 (or other ATCA compatible communications protocol) ATCA fabric channels (full-mesh topology) and two Fast Ethernet (Precision Time Protocol - PTP IEEE1588-V2 and Lan eXtensions for Instrumentation - LXI compatible) ATCA base channels (dual-star topology).

  3. Batch Processing of CMOS Compatible Feedthroughs

    DEFF Research Database (Denmark)

    Rasmussen, F.E.; Heschel, M.; Hansen, Ole


    This paper presents a technique for batch fabrication of electrical feedthroughs in CMOS wafers. The presented process is designed with specific attention on industrial applicability. The electrical feedthroughs are processed entirely by low temperature, CMOS compatible processes. Hence, the proc......This paper presents a technique for batch fabrication of electrical feedthroughs in CMOS wafers. The presented process is designed with specific attention on industrial applicability. The electrical feedthroughs are processed entirely by low temperature, CMOS compatible processes. Hence....... The feedthrough technology employs a simple solution to the well-known CMOS compatibility issue of KOH by protecting the CMOS side of the wafer using sputter deposited TiW/Au. The fabricated feedthroughs exhibit excellent electrical performance having a serial resistance of 40 mOmega and a parasitic capacitance...

  4. Materials Compatibility in High Test Hydrogen Peroxide (United States)

    Gostowski, Rudy


    Previous ratings of the compatibility of high test hydrogen peroxide (HTP) with materials are not adequate for current needs. The goal of this work was to develop a new scheme of evaluation of compatibility of HTP with various materials. Procedures were developed to enrich commercially available hydrogen peroxide to 90% concentration and to assay the product. Reactivity testing, accelerated aging of materials and calorimetry studies were done on HTP with representative metallic and non-metallic materials. It was found that accelerated aging followed by concentration determination using refractive index effectively discriminated between different Class 2 metallic materials. Preliminary experiments using Differential Scanning Calorimetry (DSC) suggest that a calorimetry experiment is the most sensitive means to assay the compatibility of HTP with materials.

  5. 英飞凌推进DDR2 FB-DIMM部署:为FB-DIMM生产商提供AMB芯片

    Institute of Scientific and Technical Information of China (English)


    英飞凌科技公司宣布正在推出双数据速率2(DDR2)全缓冲内存模块(FBDIMM)样品。容量在512MB到4GB之间的新型FB-DIMM.基于英飞凌出品的高级内存缓冲(AMB)芯片、DDR2 DRAM芯片及其自主开发的散热器。另外,英飞凌还为其他FB-DIMM生产商提供AMB逻辑芯片.并且已经将样品发给了第一批客户。

  6. Novel DDR2 mutation identified by whole exome sequencing in a Moroccan patient with spondylo-meta-epiphyseal dysplasia, short limb-abnormal calcification type. (United States)

    Mansouri, Maria; Kayserili, Hülya; Elalaoui, Siham Chafai; Nishimura, Gen; Iida, Aritoshi; Lyahyai, Jaber; Miyake, Noriko; Matsumoto, Naomichi; Sefiani, Abdelaziz; Ikegawa, Shiro


    Spondylo-meta-epiphyseal dysplasia (SMED), short limb-abnormal calcification type (SMED, SL-AC), is a very rare autosomal recessive disorder with various skeletal changes characterized by premature calcification leading to severe disproportionate short stature. Twenty-two patients have been reported until now, but only five mutations (four missense and one splice-site) in the conserved sequence encoding the tyrosine kinase domain of the DDR2 gene has been identified. We report here a novel DDR2 missense mutation, c.370C > T (p.Arg124Trp) in a Moroccan girl with SMED, SL-AC, identified by whole exome sequencing. Our study has expanded the mutational spectrum of this rare disease and it has shown that exome sequencing is a powerful and cost-effective tool for the diagnosis of clinically heterogeneous disorders such as SMED.

  7. Compatible Spatial Discretizations for Partial Differential Equations

    Energy Technology Data Exchange (ETDEWEB)

    Arnold, Douglas, N, ed.


    From May 11--15, 2004, the Institute for Mathematics and its Applications held a hot topics workshop on Compatible Spatial Discretizations for Partial Differential Equations. The numerical solution of partial differential equations (PDE) is a fundamental task in science and engineering. The goal of the workshop was to bring together a spectrum of scientists at the forefront of the research in the numerical solution of PDEs to discuss compatible spatial discretizations. We define compatible spatial discretizations as those that inherit or mimic fundamental properties of the PDE such as topology, conservation, symmetries, and positivity structures and maximum principles. A wide variety of discretization methods applied across a wide range of scientific and engineering applications have been designed to or found to inherit or mimic intrinsic spatial structure and reproduce fundamental properties of the solution of the continuous PDE model at the finite dimensional level. A profusion of such methods and concepts relevant to understanding them have been developed and explored: mixed finite element methods, mimetic finite differences, support operator methods, control volume methods, discrete differential forms, Whitney forms, conservative differencing, discrete Hodge operators, discrete Helmholtz decomposition, finite integration techniques, staggered grid and dual grid methods, etc. This workshop seeks to foster communication among the diverse groups of researchers designing, applying, and studying such methods as well as researchers involved in practical solution of large scale problems that may benefit from advancements in such discretizations; to help elucidate the relations between the different methods and concepts; and to generally advance our understanding in the area of compatible spatial discretization methods for PDE. Particular points of emphasis included: + Identification of intrinsic properties of PDE models that are critical for the fidelity of numerical

  8. Compatibility Between Electric Components in Wind Farms

    DEFF Research Database (Denmark)

    Holdyk, Andrzej; Holbøll, Joachim; Arana Aristi, Iván


    The paper describes a method for investigation of the compatibility between electric components in wind farms by identifying critical resonances at different points of an offshore wind farm (OWF), based on systematic variation of critical parameters. In this way, the design of future OWF can...... be improved at a very early stage of the process. It is also revealed what parameters are the most important ones when considering compatibility. It was observed that a change of capacitance in the collection grid shifts the resonance peaks. A change in WT transformer capacitances influences the admittance...

  9. Compatibility and testing of electronic components

    CERN Document Server

    Jowett, C E


    Compatibility and Testing of Electronic Components outlines the concepts of component part life according to thresholds of failure; the advantages that result from identifying such thresholds; their identification; and the various tests used in their detection. The book covers topics such as the interconnection of miniature passive components; the integrated circuit compatibility and its components; the semiconductor joining techniques; and the thin film hybrid approach in integrated circuits. Also covered are topics such as thick film resistors, conductors, and insulators; thin inlays for el

  10. Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6


    Hidalgo-Carcedo, Cristina; Hooper, Steven; Chaudhry, Shahid I.; Williamson, Peter; Harrington, Kevin; Leitinger, Birgit; Sahai, Erik


    Collective cell migration occurs in a range of contexts: cancer cells frequently invade in cohorts while retaining cell-cell junctions. Here we show that collective cancer cell invasion depends on reducing actomyosin contractility at sites of cell-cell contact. When actomyosin is not down-regulated at cell-cell contacts migrating cells lose cohesion. We provide a novel molecular mechanism for this down-regulation. Depletion of Discoidin Domain Receptor 1 (DDR1) blocks collective cancer cell i...

  11. A novel dwarfism with gonadal dysfunction due to loss-of-function allele of the collagen receptor gene, Ddr2, in the mouse. (United States)

    Kano, Kiyoshi; Marín de Evsikova, C; Young, James; Wnek, Christopher; Maddatu, Terry P; Nishina, Patsy M; Naggert, Jürgen K


    Smallie (slie), a spontaneous, autosomal-recessive mutation causes dwarfing and infertility in mice. The purpose of this study was to determine and characterize the underlying molecular genetic basis for its phenotype. The slie locus was mapped to chromosome 1, and fine-structure mapping narrowed the slie allele within 2 Mb between genetic markers D1Mit36 and Mpz. To pinpoint the underlying mutation quantitative real-time PCR was used to measure the relative expression levels for the genes residing within this region. Expression of one gene, Ddr2, which encodes discoidin domain receptor 2 (DDR2), was absent in slie homozygote mice. Genomic sequencing analysis detected a 150-kb deletion that extended into the Ddr2 gene transcript. Detailed phenotype analysis revealed that gonadal dysregulation underlies infertility in slie mice because all females were anovulatory and most adult males lacked spermatogenesis. The pituitary gland of prepubertal slie mice was smaller than in wild-type mice. The basal levels and gene expression for pituitary and hypothalamic hormones, and gene expression for hypothalamic-releasing hormones, were not significantly different between slie and wild-type mice. Circulating levels of IGF-1 did not differ in slie mice despite lower Igf-1 mRNA expression in the liver. After exogenous gonadotropin administration, the levels of secreted steroid hormones in both male and female adult slie mice were blunted compared to adult wild-type, but was similar to prepubertal wild-type mice. Taken together, our results indicate that the absence of DDR2 leads to growth retardation and gonadal dysfunction due to peripheral defects in hormonal-responsive pathways in slie mice.

  12. The relative roles of collagen adhesive receptor DDR2 activation and matrix stiffness on the downregulation of focal adhesion kinase in vascular smooth muscle cells. (United States)

    Bhadriraju, Kiran; Chung, Koo-Hyun; Spurlin, Tighe A; Haynes, Ross J; Elliott, John T; Plant, Anne L


    Cells within tissues derive mechanical anchorage and specific molecular signals from the insoluble extracellular matrix (ECM) that surrounds them. Understanding the role of different cues that extracellular matrices provide cells is critical for controlling and predicting cell response to scaffolding materials. Using an engineered extracellular matrix of Type I collagen we examined how the stiffness, supramolecular structure, and glycosylation of collagen matrices influence the protein levels of cellular FAK and the activation of myosin II. Our results show that (1) cellular FAK is downregulated on collagen fibrils, but not on a non-fibrillar monolayer of collagen, (2) the downregulation of FAK is independent of the stiffness of the collagen fibrils, and (3) FAK levels are correlated with levels of tyrosine phosphorylation of the collagen adhesion receptor DDR2. Further, siRNA depletion of DDR2 blocks FAK downregulation. Our results suggest that the collagen receptor DDR2 is involved in the regulation of FAK levels in vSMC adhered to Type I collagen matrices, and that regulation of FAK levels in these cells appears to be independent of matrix stiffness.

  13. Novel DDR Processing of Corn Stover Achieves High Monomeric Sugar Concentrations from Enzymatic Hydrolysis (230 g/L) and High Ethanol Concentration (10% v/v) During Fermentation

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Xiaowen; Jennings, Ed; Shekiro, Joe; Kuhn, Erik M.; O' Brien, Marykate; Wang, Wei; Schell, Daniel J.; Himmel, Mike; Elander, Richard T.; Tucker, Melvin P.


    Distilling and purifying ethanol, butanol, and other products from second and later generation lignocellulosic biorefineries adds significant capital and operating cost for biofuels production. The energy costs associated with distillation affects plant gate and life cycle analysis costs. Lower titers in fermentation due to lower sugar concentrations from pretreatment increase both energy and production costs. In addition, higher titers decrease the volumes required for enzymatic hydrolysis and fermentation vessels. Therefore, increasing biofuels titers has been a research focus in renewable biofuels production for several decades. In this work, we achieved over 200 g/L of monomeric sugars after high solids enzymatic hydrolysis using the novel deacetylation and disc refining (DDR) process on corn stover. The high sugar concentrations and low chemical inhibitor concentrations from the DDR process allowed ethanol titers as high as 82 g/L in 22 hours, which translates into approximately 10 vol% ethanol. To our knowledge, this is the first time that 10 vol% ethanol in fermentation derived from corn stover without any sugar concentration or purification steps has been reported. Techno-economic analysis shows the higher titer ethanol achieved from the DDR process could significantly reduce the minimum ethanol selling price from cellulosic biomass.

  14. 14 CFR 150.23 - Noise compatibility programs. (United States)


    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Noise compatibility programs. 150.23... (CONTINUED) AIRPORTS AIRPORT NOISE COMPATIBILITY PLANNING Development of Noise Exposure Maps and Noise Compatibility Programs § 150.23 Noise compatibility programs. (a) Any airport operator who has submitted...

  15. 47 CFR 76.1622 - Consumer education program on compatibility. (United States)


    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Consumer education program on compatibility. 76... compatibility. Cable system operators shall provide a consumer education program on compatibility matters to..., cable system operators shall briefly explain, the types of channel compatibility problems that...

  16. 46 CFR 150.150 - Exceptions to the compatibility chart. (United States)


    ... 46 Shipping 5 2010-10-01 2010-10-01 false Exceptions to the compatibility chart. 150.150 Section... CARGOES COMPATIBILITY OF CARGOES § 150.150 Exceptions to the compatibility chart. The Commandant (G-MSO... 1, the Compatibility Chart....

  17. Implementation of PCIe-SerDes-DDR3 communication in a multi-FPGA data acquisition system (United States)

    Byszuk, Adrian; Kolasiński, Piotr; Poźniak, Krzysztof; Zabołotny, Wojciech M.; Kasprowicz, Grzegorz


    This paper describes the embedded system used to store and transfer large amounts of data in a multichannel data acquisition system for the GEM detector. The stored data is used for diagnostics purposes. System consists of an embedded mini ITX motherboard connected through the PCI Express (PCIe) link to a backplane FPGA. The backplane FPGA is connected through the SerDes/GTP links to (up to) 4 carrier boards. Each carrier board is connected to (up to) 4 FMC modules. System allows for a high speed data transfers between the ITX motherboard and the backplane or carrier modules. Due to high performance/reliability requirements, special care is taken for a proper data error correction/packet retransmission scenarios. There is also need for a proper communications diagnostics and a system addressing abstraction. Due to a distributed nature of described data acquisition system, data stored in DDR memory has to have a specific structure. This structure allows for a proper synchronisation of data between all the carrier boards.

  18. A Note on (In)Compatibility Relations

    NARCIS (Netherlands)

    Sequoiah-Grayson, Sebastian; Pelis, M; Puncochar,


    Non-symmetric incompatibility relations, or non-symmetric compatibility relations, are a standard method for introducing a split negation pair on a frame. Another standard method is to reject commutation for the frame. The first task is to examine the relationship between non-symmetric incompatibili

  19. [MRI compatibility of deep brain stimulator]. (United States)

    Zhang, Yujing


    Deep brain stimulation (DBS) therapy develops rapidly in clinical application. The structures of deep brain stimulator and magnetic resonance imaging (MRI) equipment are introduced, the interactions are analyzed, and the two compatible problems of radio frequency (RF) heating and imaging artifact are summarized in this paper.

  20. Component-compatibility in historical biogeography

    NARCIS (Netherlands)

    Zandee, M.; Roos, M.C.


    -The problems of reconstructing historical relationships for areas of endemism from distributional data for groups of taxa and the cladistic relationships among the members of those groups can be solved by applying the two principles of parsimony and mutual inclusion or exclusion (compatibility) of

  1. Compositionality and Compatibility of Service Contracts

    DEFF Research Database (Denmark)

    Okika, Joseph C.; Ravn, Anders Peter


    goal is to add a representation and support for the functional aspects of service contracts to the existing non-functional aspects. Further, we investigate how to analyze, verify and validate service contracts laying emphasis on the compositionality and compatibility of service contracts....

  2. Plasmonic Modulator Using CMOS Compatible Material Platform

    DEFF Research Database (Denmark)

    Babicheva, Viktoriia; Kinsey, Nathaniel; Naik, Gururaj V.;


    In this work, a design of ultra-compact plasmonic modulator is proposed and numerically analyzed. The device l ayout utilizes alternative plas monic materials such as tr ansparent conducting oxides and titanium nitride which potentially can be applied for CMOS compatible process. The modulation...

  3. The Construal (In)compatibility Effect

    DEFF Research Database (Denmark)

    Yang, Xiaojing; Ringberg, Torsten; Mao, Huifang


    incompatible with their mental construal, while ad claims construed at a level compatible with consumers' mental construal are more effective for those who possess a less creative mindset. We document that such differences in persuasion are driven by the fact that consumers with a creative (less creative) mind...

  4. Catholic Educator Perceptions about Brain Compatible Instruction (United States)

    Koenen, Amie


    This document reports the findings of a doctoral project regarding the perceptions held by administrators and teachers of comprehensive Catholic schools in one Midwestern diocese. With the recent explosion of research in the area of the brain and brain compatible instruction it is valuable to know and understand the perceptions held by current…

  5. The mitonuclear compatibility hypothesis of sexual selection (United States)

    Hill, Geoffrey E.; Johnson, James D.


    Why females assess ornaments when choosing mates remains a central question in evolutionary biology. We hypothesize that the imperative for a choosing female to find a mate with nuclear oxidative phosphorylation (OXPHOS) genes that are compatible with her mitochondrial OXPHOS genes drives the evolution of ornaments. Indicator traits are proposed to signal the efficiency of OXPHOS function thus enabling females to select mates with nuclear genes that are compatible with maternal mitochondrial genes in the formation of OXPHOS complexes. Species-typical pattern of ornamentation is proposed to serve as a marker of mitochondrial type ensuring that females assess prospective mates with a shared mitochondrial background. The mitonuclear compatibility hypothesis predicts that the production of ornaments will be closely linked to OXPHOS pathways, and that sexual selection for compatible mates will be strongest when genes for nuclear components of OXPHOS complexes are Z-linked. The implications of this hypothesis are that sexual selection may serve as a driver for the evolution of more efficient cellular respiration. PMID:23945683

  6. Damage diagnosis and compatible repair mortars

    NARCIS (Netherlands)

    Hees, R.P.J. van


    Mortars for repair and maintenance of historic masonry have to meet specific requirements. Several authors have made contributions, however many cases of failure show that there still is quite a lack of knowledge on the compatibility of repair mortars for historic masonry. The diagnosis of the cause

  7. 9 CFR 3.7 - Compatible grouping. (United States)


    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Compatible grouping. 3.7 Section 3.7 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs...

  8. fMRI-compatible rehabilitation hand device

    Directory of Open Access Journals (Sweden)

    Tzika Aria


    Full Text Available Abstract Background Functional magnetic resonance imaging (fMRI has been widely used in studying human brain functions and neurorehabilitation. In order to develop complex and well-controlled fMRI paradigms, interfaces that can precisely control and measure output force and kinematics of the movements in human subjects are needed. Optimized state-of-the-art fMRI methods, combined with magnetic resonance (MR compatible robotic devices for rehabilitation, can assist therapists to quantify, monitor, and improve physical rehabilitation. To achieve this goal, robotic or mechatronic devices with actuators and sensors need to be introduced into an MR environment. The common standard mechanical parts can not be used in MR environment and MR compatibility has been a tough hurdle for device developers. Methods This paper presents the design, fabrication and preliminary testing of a novel, one degree of freedom, MR compatible, computer controlled, variable resistance hand device that may be used in brain MR imaging during hand grip rehabilitation. We named the device MR_CHIROD (Magnetic Resonance Compatible Smart Hand Interfaced Rehabilitation Device. A novel feature of the device is the use of Electro-Rheological Fluids (ERFs to achieve tunable and controllable resistive force generation. ERFs are fluids that experience dramatic changes in rheological properties, such as viscosity or yield stress, in the presence of an electric field. The device consists of four major subsystems: a an ERF based resistive element; b a gearbox; c two handles and d two sensors, one optical encoder and one force sensor, to measure the patient induced motion and force. The smart hand device is designed to resist up to 50% of the maximum level of gripping force of a human hand and be controlled in real time. Results Laboratory tests of the device indicate that it was able to meet its design objective to resist up to approximately 50% of the maximum handgrip force. The detailed

  9. Is automatic imitation a specialized form of stimulus-response compatibility? Dissociating imitative and spatial compatibilities. (United States)

    Boyer, Ty W; Longo, Matthew R; Bertenthal, Bennett I


    In recent years research on automatic imitation has received considerable attention because it represents an experimental platform for investigating a number of interrelated theories suggesting that the perception of action automatically activates corresponding motor programs. A key debate within this research centers on whether automatic imitation is any different than other long-term S-R associations, such as spatial stimulus-response compatibility. One approach to resolving this issue is to examine whether automatic imitation shows similar response characteristics as other classes of stimulus-response compatibility. This hypothesis was tested by comparing imitative and spatial compatibility effects with a two alternative forced-choice stimulus-response compatibility paradigm. The stimulus on each trial was a left or right hand with either the index or middle finger tapping down. Speeded responses were performed with the index or middle finger of the right hand in response to the identity or the left-right spatial position of the stimulus finger. Two different tasks were administered: one that involved responding to the stimulus (S-R) and one that involved responding to the opposite stimulus (OS-R; i.e., the one not presented on that trial). Based on previous research and a connectionist model, we predicted standard compatibility effects for both spatial and imitative compatibility in the S-R task, and a reverse compatibility effect for spatial compatibility, but not for imitative compatibility, in the OS-R task. The results from the mean response times, mean percentage of errors, and response time distributions all converged to support these predictions. A second noteworthy result was that the recoding of the finger identity in the OS-R task required significantly more time than the recoding of the left-right spatial position, but the encoding time for the two stimuli in the S-R task was equivalent. In sum, this evidence suggests that the processing of spatial

  10. The compatibility of telehealth with health-care delivery. (United States)

    Vuononvirta, Tiina; Timonen, Markku; Keinänen-Kiukaanniemi, Sirkka; Timonen, Olavi; Ylitalo, Kirsti; Kanste, Outi; Taanila, Anja


    There is no clear understanding about the concept of technology adoption in the health-care environment. Compatibility is one of the factors affecting telehealth adoption. We investigated the key factors of telehealth's compatibility with health centre activities. Qualitative research was carried out in 2007-2009, with 55 interviews in seven health centres and in one special care hospital. The people interviewed were physicians, nurses and physiotherapists. After analysing the interview material, we concluded that compatibility has three aspects: individual, process and organizational compatibility. Individual compatibility was manifested in four different ways: from the viewpoints of professionals, patients, communication and cooperation. Three aspects of process compatibility were introduced: scheduling, resources and complexity of processes. Modest organizing efforts with telehealth and even a lack of interest can be expressions of organizational compatibility. Functional and user-friendly technology is a basic precondition for telehealth compatibility. With thorough organizing, most of the compatibility challenges can be solved.

  11. Paleogeographical reconstructions compatible with Earth dilatation

    Directory of Open Access Journals (Sweden)

    G. Scalera


    Full Text Available The present research concerns the study of the possibility of an increase in the size of the Earthbecause of a still unknown process. After a previous recognition of the existence in the Pacific of shape conformities in a number of pairs of continental and oceanic boundaries (Scalera, 1991, 1993a, a search for compatibility of these results with independent data sets, paleomagnetic and geological and paleontological was undertaken. The conclusion is that the Earth's dilatation is compatible with the used data, while nothing can be affirmed with certainty about the dilatation process or its continuity or discontinuity through geological time. A tentative model of the evolution of the trench-arc-backarc systems has been provided, tuning it in agreement with a dilatational planet.

  12. Coating for components requiring hydrogen peroxide compatibility (United States)

    Yousefiani, Ali (Inventor)


    The present invention provides a heretofore-unknown use for zirconium nitride as a hydrogen peroxide compatible protective coating that was discovered to be useful to protect components that catalyze the decomposition of hydrogen peroxide or corrode when exposed to hydrogen peroxide. A zirconium nitride coating of the invention may be applied to a variety of substrates (e.g., metals) using art-recognized techniques, such as plasma vapor deposition. The present invention further provides components and articles of manufacture having hydrogen peroxide compatibility, particularly components for use in aerospace and industrial manufacturing applications. The zirconium nitride barrier coating of the invention provides protection from corrosion by reaction with hydrogen peroxide, as well as prevention of hydrogen peroxide decomposition.

  13. CMOS compatible nanoscale nonvolatile resistance switching memory. (United States)

    Jo, Sung Hyun; Lu, Wei


    We report studies on a nanoscale resistance switching memory structure based on planar silicon that is fully compatible with CMOS technology in terms of both materials and processing techniques employed. These two-terminal resistance switching devices show excellent scaling potential well beyond 10 Gb/cm2 and exhibit high yield (99%), fast programming speed (5 ns), high on/off ratio (10(3)), long endurance (10(6)), retention time (5 months), and multibit capability. These key performance metrics compare favorably with other emerging nonvolatile memory techniques. Furthermore, both diode-like (rectifying) and resistor-like (nonrectifying) behaviors can be obtained in the device switching characteristics in a controlled fashion. These results suggest that the CMOS compatible, nanoscale Si-based resistance switching devices may be well suited for ultrahigh-density memory applications.

  14. Making nonlocal reality compatible with relativity


    Nikolic, H.


    It is often argued that hypothetic nonlocal reality responsible for nonlocal quantum correlations between entangled particles cannot be consistent with relativity. I review the most frequent arguments of that sort, explain how they can all be circumvented, and present an explicit Bohmian model of nonlocal reality (compatible with quantum phenomena) that fully obeys the principle of relativistic covariance and does not involve a preferred Lorentz frame.

  15. Microwave spectrum compatibility in planetary research (United States)

    Siegmeth, A. J.


    The paper presents an overview of solar system exploration, basic functions of the Deep Space Network (DSN), deep space microwave links, space research compatibility problems, and DSN's interference susceptibility. To maintain the operational integrity of competing radio systems using the microwave spectrum, the technology must extend to make possible the shared use of the spectral ranges without the ill effects of interferences. Suggestions are given which are only examples of many possible techniques that can eliminate or reduce interferences.

  16. Migration and sustainability - compatible or contradictory?

    DEFF Research Database (Denmark)

    Røpke, Inge


    When the migration issue is discussed in a sustainability perspective, two questions are vital: 1) What is the relationship between migration and the global population growth? 2) What is the relationship between migration and consumption growth, and how does migration influence the distribution o...... of consumption possibilities both between and within industrialized and developing countries? Based on responses to these questions, it is argued that reasonably managed migration will be compatible with sustainable development....

  17. fMRI-compatible rehabilitation hand device


    Tzika Aria; Astrakas Loukas; Weinberg Brian; Triantafyllou Christina; Muto Andrew; Khanicheh Azadeh; Mavroidis Constantinos


    Abstract Background Functional magnetic resonance imaging (fMRI) has been widely used in studying human brain functions and neurorehabilitation. In order to develop complex and well-controlled fMRI paradigms, interfaces that can precisely control and measure output force and kinematics of the movements in human subjects are needed. Optimized state-of-the-art fMRI methods, combined with magnetic resonance (MR) compatible robotic devices for rehabilitation, can assist therapists to quantify, mo...

  18. Ofloxacin intravenous. Compatibility with other antibacterial agents. (United States)

    Janknegt, R; Stratermans, T; Cilissen, J; Lohman, J J; Hooymans, P M


    The physical and chemical compatibility of ofloxacin (infusion solution 100 ml = 200 mg) with amoxicillin, amoxicillin + clavulanic acid, flucloxacillin, tobramycin, gentamicin, clindamycin, vancomycin, ceftazidime and piperacillin was investigated. Upon admixture with flucloxacillin a precipitate formed between 7 and 24 hours. No other physical or chemical incompatibilities were observed with any of the other combinations. Ofloxacin may be safely combined with the tested antimicrobial drugs, except for flucloxacillin.

  19. Fully CMOS-compatible titanium nitride nanoantennas (United States)

    Briggs, Justin A.; Naik, Gururaj V.; Petach, Trevor A.; Baum, Brian K.; Goldhaber-Gordon, David; Dionne, Jennifer A.


    CMOS-compatible fabrication of plasmonic materials and devices will accelerate the development of integrated nanophotonics for information processing applications. Using low-temperature plasma-enhanced atomic layer deposition (PEALD), we develop a recipe for fully CMOS-compatible titanium nitride (TiN) that is plasmonic in the visible and near infrared. Films are grown on silicon, silicon dioxide, and epitaxially on magnesium oxide substrates. By optimizing the plasma exposure per growth cycle during PEALD, carbon and oxygen contamination are reduced, lowering undesirable loss. We use electron beam lithography to pattern TiN nanopillars with varying diameters on silicon in large-area arrays. In the first reported single-particle measurements on plasmonic TiN, we demonstrate size-tunable darkfield scattering spectroscopy in the visible and near infrared regimes. The optical properties of this CMOS-compatible material, combined with its high melting temperature and mechanical durability, comprise a step towards fully CMOS-integrated nanophotonic information processing.

  20. Double Retort System for Materials Compatibility Testing

    Energy Technology Data Exchange (ETDEWEB)

    V. Munne; EV Carelli


    With Naval Reactors (NR) approval of the Naval Reactors Prime Contractor Team (NRPCT) recommendation to develop a gas cooled reactor directly coupled to a Brayton power conversion system as the Space Nuclear Power Plant (SNPP) for Project Prometheus (References a and b) there was a need to investigate compatibility between the various materials to be used throughout the SNPP. Of particular interest was the transport of interstitial impurities from the nickel-base superalloys, which were leading candidates for most of the piping and turbine components to the refractory metal alloys planned for use in the reactor core. This kind of contamination has the potential to affect the lifetime of the core materials. This letter provides technical information regarding the assembly and operation of a double retort materials compatibility testing system and initial experimental results. The use of a double retort system to test materials compatibility through the transfer of impurities from a source to a sink material is described here. The system has independent temperature control for both materials and is far less complex than closed loops. The system is described in detail and the results of three experiments are presented.

  1. Compatibility of Segments of Thermoelectric Generators (United States)

    Snyder, G. Jeffrey; Ursell, Tristan


    A method of calculating (usually for the purpose of maximizing) the power-conversion efficiency of a segmented thermoelectric generator is based on equations derived from the fundamental equations of thermoelectricity. Because it is directly traceable to first principles, the method provides physical explanations in addition to predictions of phenomena involved in segmentation. In comparison with the finite-element method used heretofore to predict (without being able to explain) the behavior of a segmented thermoelectric generator, this method is much simpler to implement in practice: in particular, the efficiency of a segmented thermoelectric generator can be estimated by evaluating equations using only hand-held calculator with this method. In addition, the method provides for determination of cascading ratios. The concept of cascading is illustrated in the figure and the definition of the cascading ratio is defined in the figure caption. An important aspect of the method is its approach to the issue of compatibility among segments, in combination with introduction of the concept of compatibility within a segment. Prior approaches involved the use of only averaged material properties. Two materials in direct contact could be examined for compatibility with each other, but there was no general framework for analysis of compatibility. The present method establishes such a framework. The mathematical derivation of the method begins with the definition of reduced efficiency of a thermoelectric generator as the ratio between (1) its thermal-to-electric power-conversion efficiency and (2) its Carnot efficiency (the maximum efficiency theoretically attainable, given its hot- and cold-side temperatures). The derivation involves calculation of the reduced efficiency of a model thermoelectric generator for which the hot-side temperature is only infinitesimally greater than the cold-side temperature. The derivation includes consideration of the ratio (u) between the

  2. Central neuronal mechanisms of intestinal electrical stimulation: effects on duodenum distention-responsive (DD-R) neurons in the VMH of rats. (United States)

    Zhang, Jing; Zhu, Hongbing; Chen, J D Z


    Intestinal electrical stimulation (IES) has been shown to produce inhibitory effects on gastric contractions, gastric emptying, food intake and body weight in rats and dogs, suggesting a therapeutic potential for obesity. The aims of this study were (1) to test the hypothesis that the neurons in the VMH are involved in the central mechanisms of IES treatment for obesity; (2) to compare the effects of IES at the duodenum and IES at the ileum on neuronal activities of the VMH; (3) to better understand if the neuronal activity modulated by IES was mediated via the vagal pathway. Extracellular potentials of neurons in the VMH were recorded in 18 anesthetized rats. IES at the duodenum or ileum was performed in duodenal-distention responsive (DD-R) neurons with 3 sets of parameters (IES-1 with trains of short-pulses: 4mA, 2s-on, 3s-off, 2ms, 20Hz; IES-2 with long-pulses: 6mA, 20cpm, 100ms; IES-3, same as IES-1 but 40Hz). IES-1 at the duodenum and the ileum activated 70.6% and 73.3% of the DD-R neurons, respectively. Similar percentages of the neurons were activated with IES-3 at the duodenum and the ileum (70.6% vs. 66.7%, P=0.91), respectively. IES-2 at these locations activated only 25% and 46.2% of the DD-R neurons, respectively (P>0.05). IES at the duodenum with parameter set, IES-1 or IES-3 was significantly more potent than the parameter set, IES-2 (neuronal activation: 70.6% vs. 25%, PDD, and IES with trains of short-pulses seems more effective than IES with long-pulses. The vagal pathway and extra-vagal pathways are involved in the modulatory effects of IES on the central neurons in the satiety center.

  3. DDR2-CYR61-MMP1 Signaling Pathway Promotes Bone Erosion in Rheumatoid Arthritis Through Regulating Migration and Invasion of Fibroblast-Like Synoviocytes. (United States)

    Huang, Tong-Lie; Mu, Nan; Gu, Jin-Tao; Shu, Zhen; Zhang, Kuo; Zhao, Jin-Kang; Zhang, Cun; Hao, Qiang; Li, Wei-Na; Zhang, Wang-Qian; Liu, Nan-Nan; Zhang, Yong; Zhang, Wei; Xue, Xiao-Chang; Zhang, Ying-Qi


    Regulation of matrix metalloproteinases (MMPs) by collagen in the fibroblast-like synoviocytes (FLSs) plays a critical role in joint destruction in rheumatoid arthritis (RA). Our previous study indicated that discoidin receptor 2 (DDR2) mediated collagen upregulation of MMPs. However, the precise underlying mechanism remains unclear. We report here that CYR61, a secreted, extracellular matrix-associated signaling protein which is capable of regulating a broad range of cellular activities, including cell adhesion, migration, proliferation, and apoptosis, is significantly upregulated in collagen II-stimulated RA FLS. Further studies found that collagen II-activated phosphorylated-DDR2 induces CYR61 through activation of transcription factor activator protein 1 (AP-1). The elevated CYR61, in turn, accelerates MMP1 production via ETS1 (ETS proto-oncogene 1). In addition, CYR61 significantly promotes FLS invasion and migration. Blockade of CYR61 by an adenovirus expressing CYR61 shRNA (Ad-shCYR61) in vivo remarkably ameliorated the severity of arthritis, reduced inflammatory cytokine secretion, and attenuated bone erosion as detected by micro-computed tomography (μCT), in collagen-induced arthritis (CIA) rats. Taken together, we uncovered the Collagen II-DDR2-AP-1-CYR61-ETS1-MMP1 loop in RA FLS. In which, CYR61 acts as a hinge to promote cartilage damage through regulating FLS invasion, migration, and MMP1 production and the inflammatory cascade in RA. Thus, CYR61 may be a promising diagnostic and therapeutic target for RA treatment. © 2016 American Society for Bone and Mineral Research.

  4. Optical glass compatibility for the design of apochromatic systems


    Gruescu C.; Nicoara I.; Popov D.; Bodea R.; Hora H.


    The design of apochromatic systems is difficult because of two problems: the glass sorts compatibility and the c1/ca arbitrary input ratio. The optical glass manufacturers offer a wide range of sorts, so that the choice of triplet compatible glasses becomes itself an important separate problem. The paper provides a solution of mathematical modeling for the glass compatibility and, practically, analyses the sorts presented by Schott GmbH. The original software provided 22 compatible glass trip...

  5. Die Fußballclubs Rot-Weiß Erfurt und Carl Zeiss Jena und ihre Vorgänger in der DDR : ein Vergleich ihrer Bedingungen


    Kummer, Michael


    Der SC Motor/FC Carl Zeiss Jena war seit Ende der 50-er Jahre bis in die 80-er Jahre hinein ein vom DFV der DDR und vom DTSB immer wieder benannter und bestätigter Schwerpunktclub innerhalb der sogenannten zivilen Clubs. Der SC Turbine/FC Rot-Weiß Erfurt konnte diesen Status innerhalb des Fußballverbands dagegen nie erreichen. Die zentrale Frage dieser Dissertation nach den spezifischen Bedingungsgefügen des zivilen Schwerpunktclubs FC Carl Zeiss Jena (und Vorgänger) und des zivilen Nichtschw...

  6. 47 CFR 76.1621 - Equipment compatibility offer. (United States)


    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Equipment compatibility offer. 76.1621 Section... MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Notices § 76.1621 Equipment compatibility offer. Cable system... individual compatibility problems. (d) Cable operators shall provide such equipment at the request...

  7. 49 CFR 175.78 - Stowage compatibility of cargo. (United States)


    ... 49 Transportation 2 2010-10-01 2010-10-01 false Stowage compatibility of cargo. 175.78 Section 175... Loading, Unloading and Handling § 175.78 Stowage compatibility of cargo. (a) For stowage on an aircraft..., Compatibility Group S, explosives are permitted to be transported aboard a passenger aircraft. Only...

  8. 46 CFR Figure 1 to Part 150 - Compatibility Chart (United States)


    ... 46 Shipping 5 2010-10-01 2010-10-01 false Compatibility Chart 1 Figure 1 to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, Fig. 1 Figure 1 to Part 150—Compatibility Chart EC02FE91.079...

  9. 14 CFR Appendix B to Part 150 - Noise Compatibility Programs (United States)


    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Noise Compatibility Programs B Appendix B... (CONTINUED) AIRPORTS AIRPORT NOISE COMPATIBILITY PLANNING Pt. 150, App. B Appendix B to Part 150—Noise Compatibility Programs Sec. B150.1Scope and purpose. Sec. B150.3Requirement for noise map. Sec....

  10. Are Automatic Imitation and Spatial Compatibility Mediated by Different Processes? (United States)

    Cooper, Richard P.; Catmur, Caroline; Heyes, Cecilia


    Automatic imitation or "imitative compatibility" is thought to be mediated by the mirror neuron system and to be a laboratory model of the motor mimicry that occurs spontaneously in naturalistic social interaction. Imitative compatibility and spatial compatibility effects are known to depend on different stimulus dimensions--body…

  11. Compatible Relaxation and Coarsening in Algebraic Multigrid

    Energy Technology Data Exchange (ETDEWEB)

    Brannick, J J; Falgout, R D


    We introduce a coarsening algorithm for algebraic multigrid (AMG) based on the concept of compatible relaxation (CR). The algorithm is significantly different from standard methods, most notably because it does not rely on any notion of strength of connection. We study its behavior on a number of model problems, and evaluate the performance of an AMG algorithm that incorporates the coarsening approach. Lastly, we introduce a variant of CR that provides a sharper metric of coarse-grid quality and demonstrate its potential with two simple examples.

  12. Compatibility testing of vacuum seal materials (United States)

    Foster, P. A.; Rodin, W. A.


    Small scale materials compatibility testing was conducted for three elastomers considered for use as vacuum seal materials: Adiprene MOCA-cured; Adiprene Cyanacured; and Sylgard silastic rubber. The tests were conducted using orthogonal array designed experiments for each of the elastomers placed in contact with three materials commonly used during weapon disassembly operations: Duxseal, Sylgard 186 grease, and 2-propyl alcohol. The test results indicated that only the 2-propyl alcohol had a significant effect on the elastomer hardness and physical properties. The alcohol had the largest effect on the two Adiprene materials, and the silastic rubber was the least affected.

  13. Study of Electromagnetism Compatibility of Bleeper Station

    Institute of Scientific and Technical Information of China (English)


    Transmitted power will decrease, cross-modulate distortion and inter-modulate distortion will be caused and antenna pattern will shift if transmitted antennas are fixed together. All these will lead to the alteration of area coverage. According to the basic theory of electromagnetism compatibility a computer model is established. We do some quantitative analysis of the problems above and give total number, arrangement mode and distance between antennas of bleeper station that operate at 150 MHz. The relation of these factors above are also given. All these are basis of the arrangement of antenna group of bleeper station.

  14. Integrated environmentally compatible soldering technologies. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Hosking, F.M.; Frear, D.R.; Iman, R.L.; Keicher, D.M.; Lopez, E.P.; Peebles, H.C.; Sorensen, N.R.; Vianco, P.T.


    Chemical fluxes are typically used during conventional electronic soldering to enhance solder wettability. Most fluxes contain very reactive, hazardous constituents that require special storage and handling. Corrosive flux residues that remain on soldered parts can severely degrade product reliability. The residues are removed with chlorofluorocarbon (CFC), hydrochlorofluorocarbon (HCFC), or other hazardous solvents that contribute to ozone depletion, release volatile organic compounds into the atmosphere, or add to the solvent waste stream. Alternative materials and processes that offer the potential for the reduction or elimination of cleaning are being developed to address these environmental issues. Timing of the effort is critical, since the targeted chemicals will soon be heavily taxed or banned. DOE`s Office of Environmental Restoration and Waste Management (DOE/EM) has supported Sandia National Laboratories` Environmentally Conscious Manufacturing Integrated Demonstration (ECMID). Part of the ECM program involves the integration of several environmentally compatible soldering technologies for assembling electronics devices. Fluxless or {open_quotes}low-residue/no clean{close_quotes} soldering technologies (conventional and ablative laser processing, controlled atmospheres, ultrasonic tinning, protective coatings, and environmentally compatible fluxes) have been demonstrated at Sandia (SNL/NM), the University of California at Berkeley, and Allied Signal Aerospace-Kansas City Division (AS-KCD). The university demonstrations were directed under the guidance of Sandia staff. Results of the FY93 Soldering ID are presented in this report.

  15. Electromagnetic Compatibility Design for Powertrain Control Module

    Institute of Scientific and Technical Information of China (English)

    WANG Yu-ming; CUI Tao; LIU Bo-lan; ZHANG Fu-jun


    In order to improve the electromaagnetic compatibility of powertrain control module (PCM),a system procedure of vehicular PCM electromagnetic alteration is presented in this paper.First of all,the box of the PCM is divided into different cabins to eliminate interferences between power supply circuit,analog circuit and digital circuit.Secondly,the working principle and electromagnetic (EM) characters of all the signals adopted by a typical PCM are analyzed.Then according to specific electromagnetic characters,different measures are adopted in corresponding signal process circuits or signal transfer cables,such as ground layout designing,power supply protecting,signal shielding and drive cable interference suppressing.Finally,further improvement may also needed regarding to practical electromagnetic compatibility test effects.The final test shows that,with all the measures mentioned above,the conducted emission of a PCM can be reduced by 20 dB;meanwhile,the radiated emission can be reduced by 30 dB comparing to the original system.

  16. Electromagnetic Compatibility of Matrix Converter System

    Directory of Open Access Journals (Sweden)

    S. Fligl


    Full Text Available The presented paper deals with matrix converters pulse width modulation strategies design with emphasis on the electromagnetic compatibility. Matrix converters provide an all-silicon solution to the problem of converting AC power from one frequency to another, offering almost all the features required of an ideal static frequency changer. They possess many advantages compared to the conventional voltage or current source inverters. A matrix converter does not require energy storage components as a bulky capacitor or an inductance in the DC-link, and enables the bi-directional power flow between the power supply and load. The most of the contemporary modulation strategies are able to provide practically sinusoidal waveforms of the input and output currents with negligible low order harmonics, and to control the input displacement factor. The perspective of matrix converters regarding EMC in comparison with other types of converters is brightly evident because it is no need to use any equipment for power factor correction and current and voltage harmonics reduction. Such converter with proper control is properly compatible both with the supply mains and with the supplied load. A special digital control system was developed for the realized experimental test bed which makes it possible to achieve greater throughput of the digital control system and its variability.

  17. The role of collagen receptors Endo180 and DDR-2 in the foreign body reaction against non-crosslinked collagen and gelatin. (United States)

    Ye, Qingsong; Harmsen, Martin C; Ren, Yijin; Bank, Ruud A


    Despite the use of collagen-derived scaffolds in regenerative medicine, little is known about the degradation mechanisms of these scaffolds in vivo. Non-crosslinked dermal sheep (NDSC) and gelatin disks were implanted subcutaneously in mice. NDSC disks showed a very low degradation rate, despite the presence of high numbers of macrophages and the influx of neutrophils. This was attributed to the presence of the matrix metalloproteinase inhibitor TIMP-1. The limited degradation occurred mainly in the later stages of the foreign body reaction, and could be attributed to (1) phagocytosis by macrophages due to a co-expression of Endo180 and MT1-MMP on these cells (intracellular degradation) and (2) the presence of MMP-13 due to an upregulation of the expression of the DDR-2 receptor (extracellular degradation). In contrast, gelatin disks degraded quickly, due to the efficient formation of large giant cells as well as the presence of MMP-13; the inhibitor TIMP-1 was absent. The DDR-2 receptor was not expressed in the gelatin disks. Endo180 and MT1-MMP were expressed, but at most times no co-expression was seen. We conclude that the physical state of collagen (native or denatured) had a dramatic outcome on the degradation rate and provoked a completely different foreign body reaction.

  18. Large-signal characterizations of DDR IMPATT devices based on group III-V semiconductors at millimeter-wave and terahertz frequencies (United States)

    Acharyya, Aritra; Mallik, Aliva; Banerjee, Debopriya; Ganguli, Suman; Das, Arindam; Dasgupta, Sudeepto; Banerjee, J. P.


    Large-signal (L-S) characterizations of double-drift region (DDR) impact avalanche transit time (IMPATT) devices based on group III-V semiconductors such as wurtzite (Wz) GaN, GaAs and InP have been carried out at both millimeter-wave (mm-wave) and terahertz (THz) frequency bands. A L-S simulation technique based on a non-sinusoidal voltage excitation (NSVE) model developed by the authors has been used to obtain the high frequency properties of the above mentioned devices. The effect of band-to-band tunneling on the L-S properties of the device at different mm-wave and THz frequencies are also investigated. Similar studies are also carried out for DDR IMPATTs based on the most popular semiconductor material, i.e. Si, for the sake of comparison. A comparative study of the devices based on conventional semiconductor materials (i.e. GaAs, InP and Si) with those based on Wz-GaN shows significantly better performance capabilities of the latter at both mm-wave and THz frequencies.

  19. Tierschutz in der DDR



    The topic of the present study is to depict the role of animal welfare in the former German Democratic Republic (GDR). In addition to the study of the influencing ideological and political factors, the analysis of the then existing legal basis and an explanation of the importance of animal welfare in veterinary education are performed. Furthermore, the organisation of animal welfare in the GDR is picked out as a central theme. A major issue is the husbandry of the bovine and porcine species a...

  20. Compatibility of embryonic stem cells with biomaterials. (United States)

    Handschel, Jörg; Berr, Karin; Depprich, Rita; Naujoks, Christian; Kübler, Norbert R; Meyer, Ulrich; Ommerborn, Michelle; Lammers, Lydia


    Periodontal bone defects and atrophy of the jaws in an aging population are of special concern. Tissue engineering using embryonic stem cells (ESCs) and biomaterials may offer new therapeutic options. The purpose of this study is to evaluate the compatibility of ESCs with biomaterials and the influence of biomaterials on the osteogenic gene expression profile.Therefore, ESCs are cultured with various biomaterials. The cytocompatibility of murine ESCs is measured regarding the proliferation of the cells on the materials by CyQUANT assay, the morphology by scanning electron microscopy, and the influence on the gene expression by real time PCR.The results show that insoluble collagenous bone matrix, followed by beta-tricalciumphosphate, is most suitable for bone tissue engineering regarding cell proliferation, and phenotype. The gene expression analysis indicates that biomaterials do influence the gene expression of ESCs.Our results provide new insight into the cytocompatibility of ESCs on different scaffolds.

  1. Fuel System Compatibility Issues for Prometheus-1

    Energy Technology Data Exchange (ETDEWEB)

    DC Noe; KB Gibbard; MH Krohn


    Compatibility issues for the Prometheus-1 fuel system have been reviewed based upon the selection of UO{sub 2} as the reference fuel material. In particular, the potential for limiting effects due to fuel- or fission product-component (cladding, liner, spring, etc) chemical interactions and clad-liner interactions have been evaluated. For UO{sub 2}-based fuels, fuel-component interactions are not expected to significantly limit performance. However, based upon the selection of component materials, there is a potential for degradation due to fission products. In particular, a chemical liner may be necessary for niobium, tantalum, zirconium, or silicon carbide-based systems. Multiple choices exist for the configuration of a chemical liner within the cladding; there is no clear solution that eliminates all concerns over the mechanical performance of a clad/liner system. A series of tests to evaluate the performance of candidate materials in contact with real and simulated fission products is outlined.

  2. Engine Materials Compatibility with Alternate Fuels

    Energy Technology Data Exchange (ETDEWEB)

    Thomson, Jeffery K [ORNL; Pawel, Steven J [ORNL; Wilson, Dane F [ORNL


    The compatibility of aluminum and aluminum alloys with synthetic fuel blends comprised of ethanol and reference fuel C (a 50/50 mix of toluene and iso-octane) was examined as a function of water content and temperature. Commercially pure wrought aluminum and several cast aluminum alloys were observed to be similarly susceptible to substantial corrosion in dry (< 50 ppm water) ethanol. Corrosion rates of all the aluminum materials examined were accelerated by increased temperature and ethanol content in the fuel mixture, but inhibited by increased water content. Pretreatments designed to stabilize passive films on aluminum increased the incubation time for onset of corrosion, suggesting film stability is a significant factor in the mechanism of corrosion.

  3. Engine Materials Compatability with Alternative Fuels

    Energy Technology Data Exchange (ETDEWEB)

    Pawel, Steve [Oak Ridge National Laboratory; Moore, D. [USCAR


    The compatibility of aluminum and aluminum alloys with synthetic fuel blends comprised of ethanol and reference fuel C (a 50/50 mix of toluene and iso-octane) was examined as a function of water content and temperature. Commercially pure wrought aluminum and several cast aluminum alloys were observed to be similarly susceptible to substantial corrosion in dry (< 50 ppm water) ethanol. Corrosion rates of all the aluminum materials examined were accelerated by increased temperature and ethanol content in the fuel mixture, but inhibited by increased water content. Pretreatments designed to stabilize passive films on aluminum increased the incubation time for onset of corrosion, suggesting film stability is a significant factor in the mechanism of corrosion.

  4. Catalytic nanoarchitectonics for environmentally compatible energy generation

    Directory of Open Access Journals (Sweden)

    Hideki Abe


    Full Text Available Environmentally compatible energy management is one of the biggest challenges of the 21st century. Low-temperature conversion of chemical to electrical energy is of particular importance to minimize the impact to the environment while sustaining the consumptive economy. In this review, we shed light on one of the most versatile energy-conversion technologies: heterogeneous catalysts. We establish the integrity of structural tailoring in heterogeneous catalysts at different scales in the context of an emerging paradigm in materials science: catalytic nanoarchitectonics. Fundamental backgrounds of energy-conversion catalysis are first provided together with a perspective through state-of-the-art energy-conversion catalysis including catalytic exhaust remediation, fuel-cell electrocatalysis and photosynthesis of solar fuels. Finally, the future evolution of catalytic nanoarchitectonics is overviewed: possible combinations of heterogeneous catalysts, organic molecules and even enzymes to realize reaction-selective, highly efficient and long-life energy conversion technologies which will meet the challenge we face.

  5. Ensuring Query Compatibility with Evolving XML Schemas

    CERN Document Server

    Genevès, Pierre; Quint, Vincent


    During the life cycle of an XML application, both schemas and queries may change from one version to another. Schema evolutions may affect query results and potentially the validity of produced data. Nowadays, a challenge is to assess and accommodate the impact of theses changes in rapidly evolving XML applications. This article proposes a logical framework and tool for verifying forward/backward compatibility issues involving schemas and queries. First, it allows analyzing relations between schemas. Second, it allows XML designers to identify queries that must be reformulated in order to produce the expected results across successive schema versions. Third, it allows examining more precisely the impact of schema changes over queries, therefore facilitating their reformulation.

  6. Developing 2 C-compatible investment criteria

    Energy Technology Data Exchange (ETDEWEB)

    Roeser, Frauke [NewClimate - Institute for Climate Policy and Global Sustainability gGmbH, Bonn (Germany); Weischer, Lutz [Germanwatch e.V., Koeln (Germany); Thomae, Jakob [2degrees Investing Initiative, New York, NY (United States); Hoehne, Niklas; Hagemann, Markus; El Alaoui, Alexander; Bals, Christoph; Eckstein, David; Kreft, Soenke; Rosse, Morten


    This report studies the development of criteria for assessing the compatibility of financial investments with the international goal to limit global temperature increase to below 2 C above pre-industrial levels. The findings are intended as a starting point and a key input for a longer term process to develop consensus-based 2 C investing criteria. The focus here is placed on investments in projects and physical assets, in particular of development and climate finance organisations. In order to limit global temperature increase to 2 C, global greenhouse gas (GHG) emissions will have to be reduced significantly, eventually to zero, during the course of this century. This requires shifting capital from high to low carbon investments as well as significant capital mobilisation for investments in 2 C-compatible infrastructure. Given the long lifetime of physical assets, and the urgency of decarbonisation over the coming decades, this needs to begin today. Public financial institutions can play a prominent role in contributing to aligning investment flows with the 2 C limit, as well as in closing the current infrastructure investment gap, responding to their explicit or implicit climate mandates and leadership role in the finance sector. The majority of international financial institutions integrate climate considerations into their finance decisions to some degree, and are familiar with different types of criteria, including positive and negative lists, qualitative and quantitative benchmarks, and the use of shadow carbon pricing. However, current approaches do not link to the 2 C limit. 2 C investment criteria are therefore needed to guide investors in this regard. Such criteria may also support other purposes, including an understanding of climate risks and improved reporting and accountability.

  7. CMOS-compatible spintronic devices: a review (United States)

    Makarov, Alexander; Windbacher, Thomas; Sverdlov, Viktor; Selberherr, Siegfried


    For many decades CMOS devices have been successfully scaled down to achieve higher speed and increased performance of integrated circuits at lower cost. Today’s charge-based CMOS electronics encounters two major challenges: power dissipation and variability. Spintronics is a rapidly evolving research and development field, which offers a potential solution to these issues by introducing novel ‘more than Moore’ devices. Spin-based magnetoresistive random-access memory (MRAM) is already recognized as one of the most promising candidates for future universal memory. Magnetic tunnel junctions, the main elements of MRAM cells, can also be used to build logic-in-memory circuits with non-volatile storage elements on top of CMOS logic circuits, as well as versatile compact on-chip oscillators with low power consumption. We give an overview of CMOS-compatible spintronics applications. First, we present a brief introduction to the physical background considering such effects as magnetoresistance, spin-transfer torque (STT), spin Hall effect, and magnetoelectric effects. We continue with a comprehensive review of the state-of-the-art spintronic devices for memory applications (STT-MRAM, domain wall-motion MRAM, and spin-orbit torque MRAM), oscillators (spin torque oscillators and spin Hall nano-oscillators), logic (logic-in-memory, all-spin logic, and buffered magnetic logic gate grid), sensors, and random number generators. Devices with different types of resistivity switching are analyzed and compared, with their advantages highlighted and challenges revealed. CMOS-compatible spintronic devices are demonstrated beginning with predictive simulations, proceeding to their experimental confirmation and realization, and finalized by the current status of application in modern integrated systems and circuits. We conclude the review with an outlook, where we share our vision on the future applications of the prospective devices in the area.

  8. The resupply interface mechanism RMS compatibility test (United States)

    Jackson, Stewart W.; Gallo, Frank G.


    Spacecraft on-orbit servicing consists of exchanging components such as payloads, orbital replacement units (ORUs), and consumables. To accomplish the exchange of consumables, the receiving vehicle must mate to the supplier vehicle. Mating can be accomplished by a variety of docking procedures. However, these docking schemes are mission dependent and can vary from shuttle bay berthing to autonomous rendezvous and docking. Satisfying the many docking conditions will require use of an innovative docking device. The device must provide fluid, electrical, pneumatic and data transfer between vehicles. Also, the proper stiffness must be obtained and sustained between the vehicles. A device to accomplish this, the resupply interface mechanism (RIM), was developed. The RIM is a unique device because it grasps the mating vehicle, draws the two vehicles together, simultaneously mates all connectors, and rigidizes the mating devices. The NASA-Johnson Manipulator Development Facility was used to study how compatible the RIM is to on orbit docking and berthing. The facility contains a shuttle cargo bay mockup with a remote manipulator system (RMS). This RMS is used to prepare crew members for shuttle missions involving spacecraft berthing operations. The MDF proved to be an excellant system for testing the RIM/RMS compatibility. The elements examined during the RIM JSC test were: RIM gross and fine alignment; berthing method sequence; visual cuing aids; utility connections; and RIM overall performance. The results showed that the RIM is a good device for spacecraft berthing operations. Mating was accomplished during every test run and all test operators (crew members) felt that the RIM is an effective device. The purpose of the JSC RIM test and its results are discussed.

  9. Dicty_cDB: AHB141 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ne RP23-17B8 on chromosome X. 44 0.094 2 AC118772 |AC118772.5 Rattus norvegicus 10 BAC CH230-404C20 ('s Hospital Oakland Research Institute) complete sequence. 38 0.096 2 AC109206 |

  10. Dicty_cDB: AHB116 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value... producing significant alignments: (bits) Value N AF057019 |AF057019.1 Dictyostel...ore E Sequences producing significant alignments: (bits) Value ( O76329 ) RecName: Full=Interaptin; AltName:

  11. Dicty_cDB: AHB122 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ot during/after fruit set, Cornell University Lycopersicon esculentum cDNA clone cLEX14G21 5', mRNA sequence...e QHJ21N12, mRNA sequence. 54 1e-11 3 AI775579 |AI775579.1 EST256679 tomato resistant, Cornell...T311828 tomato root during/after fruit set, Cornell University Lycopersicon esculentum cDNA clone cLEX10C9 5

  12. Dicty_cDB: AHB208 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 312837 tomato root during/after fruit set, Cornell University Lycopersicon esculentum cDNA clone cLEX14G21 5...i aconitase mRNA, partial cds. 58 6e-11 3 AI775579 |AI775579.1 EST256679 tomato resistant, Cornell...1 EST311828 tomato root during/after fruit set, Cornell University Lycopersicon esculentum cDNA clone cLEX10

  13. Dicty_cDB: AHB160 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available tica genomic, DNA sequence. 66 5e-10 2 BE325928 |BE325928.2 NF084H07ST1F1061 Developing stem Medicago trunca...tula cDNA clone NF084H07ST 5', mRNA sequence. 58 2e-09 3 AW692808 |AW692808.2 NF059H03ST1F1031 Developing st

  14. Dicty_cDB: AHB357 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available eatment prescreened for removal of highly abundant transcripts Mesembryanthemum crystallinum cDNA clone MCR0...e-07 2 BM301463 |BM301463.1 MCR046C02_25968 Ice plant Lambda Uni-Zap XR expression library, 48 hours NaCl tr

  15. Dicty_cDB: AHB249 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available haliana DNA chromoso... 130 4e-40 AK227321_1( AK227321 |pid:none) Arabidopsis thaliana mRNA for hypo... 130 ...4e-40 AK221976_1( AK221976 |pid:none) Arabidopsis thaliana mRNA for hypo... 130 4e-40 AK230210_1( AK230210 | Arabidopsis thaliana mRNA for hypo... 130 7e-40 AK101151_1( AK101151 |p

  16. Dicty_cDB: AHB169 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 27321_1( AK227321 |pid:none) Arabidopsis thaliana mRNA for hypo... 130 2e-37 AK221976_1( AK221976 |pid:none)... Arabidopsis thaliana mRNA for hypo... 130 2e-37 AK230210_1( AK230210 |pid:none) Arabidopsis thaliana mRNA for hypo.

  17. Dicty_cDB: AHB206 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available complete cds. 103 2e-21 2 BH150585 |BH150585.1 ENTPT01TF Entamoeba histolytica Shear...ed DNA Entamoeba histolytica genomic, DNA sequence. 40 10 1 BH132473 |BH132473.1 ENTON74TF Entamoeba histolytica Shear...ed DNA Entamoeba histolytica genomic, DNA sequence. 40 10 1 AZ549739 |AZ549739.1 ENTFT23TF Entamoeba histolytica Shear...OB90TF Entamoeba histolytica Sheared DNA Entamoeba histolytica genomic, DNA seque...nce. 40 10 1 AZ675565 |AZ675565.1 ENTKR79TR Entamoeba histolytica Sheared DNA Entamoeba histolytica genomic,

  18. Dicty_cDB: AHB170 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Value N BI742991 |BI742991.1 kx37e02.y1 Parastrongyloides trichosuri IL pAMP1 v1 ... ;, mRNA sequence. 70 5e-09 2 BI743756 |BI743756.1 kx52f02.y1 Parastrongyloides trichosuri PA pAMP1 v1 Chiapelli McCarter Parastrongy...0 5e-09 2 BI501287 |BI501287.1 kx30d02.y1 Parastrongyloides trichosuri PA pAMP1 v...1 Chiapelli McCarter Parastrongyloides trichosuri cDNA 5' similar to TR:O08810 O08810 U5-116KD. ;, mRNA sequ...ence. 70 7e-09 2 BI743844 |BI743844.1 kx53f10.y1 Parastrongyloides trichosuri PA pAMP1 v1 Chiapelli McCarter Parastrongyloides

  19. Dicty_cDB: AHB184 [Dicty_cDB

    Lifescience Database Archive (English)


  20. Dicty_cDB: AHB229 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 751 |pid:none) HIV-1 isolate pt6w20 from Italy in... 47 0.001 DQ354122_2( DQ354122 |pid:none) HIV-1 isolate ...002 EU908759_1( EU908759 |pid:none) HIV-1 isolate pt4bl from Italy int... 46 0.00

  1. Dicty_cDB: AHB111 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 62 of 118 of the complete sequence. 62 7e-06 4 AF414117 |AF414117.1 Drosophila melanogaster stardust...4118 |AF414118.1 Drosophila melanogaster stardust protein GUK1 isoform (sdt) mRNA, complete cds, alternative

  2. The Electromagnetic Compatibility Design of the Wireless Sensor Network Node

    Institute of Scientific and Technical Information of China (English)


    <正>This paper is concerned with the sensor nodes’ hardware design of the wireless sensor network.We focus on the electromagnetic compatibility design of the printed circuit board.In this paper,we will give a schematic diagram first,and then,according to the layout,wiring rules and the knowledge of electromagnetic compatibility, we will present the design of the printed circuit board which has a good characteristic of electromagnetic compatibility.

  3. Wie te laat komt! : het denken en handelen van de leden van het Politbüro en de regering van de DDR met betrekking tot het binnen- en buitenlands beleid gedurende de jaren 1985-1989

    NARCIS (Netherlands)

    Vogel, Pieter Johannes


    Met toepassing van de sociaal-constructivistische theorie van Wendt en de neo-institutionele theorie van Sabatier e.a. onderzocht Peter Vogel de situatie binnen het Politbüro en de regering in de nadagen (1985- 1989) van de DDR. Hij keek daarbij in hoeverre en in welke mate mentale constructies, zoa

  4. Polyurethane Organosilicate Nanocomposites as Blood Compatible Coatings

    Directory of Open Access Journals (Sweden)

    Johnson H. Y. Chung


    Full Text Available Polymer clay nanocomposites (NCs show remarkable potential in the field of drug delivery due to their enhanced barrier properties. It is hypothesised that well dispersed clay particles within the polymer matrix create a tortuous pathway for diffusing therapeutic molecules, thereby resulting in more sustained release of the drug. As coatings for medical devices, these materials can simultaneously modulate drug release and improve the mechanical performance of an existing polymer system without introducing additional materials with new chemistries that can lead to regulatory concerns. In this study, polyurethane organosilicate nanocomposites (PUNCs coated onto stainless steel wires were evaluated for their feasibility as blood compatible coatings and as drug delivery systems. Heparin was selected as the model drug to examine the impact of silicate loading and modifier chain length in modulating release. Findings revealed that better dispersion was achieved from samples with lower clay loadings and longer alkyl chains. The blood compatibility of PUNCs as assessed by thrombin generation assays showed that the addition of silicate particles did not significantly decrease the thrombin generation lag time (TGT, p = 0.659 or the peak thrombin (p = 0.999 of polyurethane (PU. PUNC coatings fabricated in this research were not cytotoxic as examined by the cell growth inhibition assay and were uniformly intact, but had slightly higher growth inhibition compared to PU possibly due to the presence of organic modifiers (OM. The addition of heparin into PUNCs prolonged the TGT, indicating that heparin was still active after the coating process. Cumulative heparin release profiles showed that the majority of heparin released was from loosely attached residues on the surface of coils. The addition of heparin further prolonged the TGT as compared to coatings without added heparin, but a slight decrease in heparin activity was observed in the NCs

  5. Compatibility Determination [Public Use on Necedah National Wildlife Refuge (United States)

    US Fish and Wildlife Service, Department of the Interior — Compatibility determinations for wildlife observation and photography, interpretation and environmental education, hunting, fishing, forest management (timber sales...

  6. [Magnetic resonance compatibility research for coronary mental stents]. (United States)

    Wang, Ying; Liu, Li; Wang, Shuo; Shang, Ruyao; Wang, Chunren


    The objective of this article is to research magnetic resonance compatibility for coronary mental stents, and to evaluate the magnetic resonance compatibility based on laboratory testing results. Coronary stents magnetic resonance compatibility test includes magnetically induced displacement force test, magnetically induced torque test, radio frequency induced heating and evaluation of MR image. By magnetic displacement force and torque values, temperature, and image distortion values to determine metal coronary stent demagnetization effect. The methods can be applied to test magnetic resonance compatibility for coronary mental stents and evaluate its demagnetization effect.

  7. Electromagnetic compatibility in railways. Analysis and management

    Energy Technology Data Exchange (ETDEWEB)

    Ogunsola, Ade [Parsons Group International, Abu Dhabi (United Arab Emirates); Mariscotti, Andrea [Genoa Univ. (Italy)


    Recent research on electromagnetic compatibility (EMC) applied to railway systems. Focuses on the principles and application of EMC concepts to railway signalling, communications, power/traction and rolling stocks. Written by leading experts in the field. A railway is a complex distributed engineering system: the construction of a new railway or the modernisation of a existing one requires a deep understanding of the constitutive components and their interaction, inside the system itself and towards the outside world. The former covers the various subsystems (featuring a complex mix of high power sources, sensitive safety critical systems, intentional transmitters, etc.) and their interaction, including the specific functions and their relevance to safety. The latter represents all the additional possible external victims and sources of electromagnetic interaction. EMC thus starts from a comprehension of the emissions and immunity characteristics and the interactions between sources and victims, with a strong relationship to electromagnetics and to system modeling. On the other hand, the said functions are achieved and preserved and their relevance for safety is adequately handled, if the related requirements are well posed and managed throughout the process from the beginning. The link is represented by standards and their correct application, as a support to analysis, testing and demonstration.

  8. Oxygen Compatibility Assessment of Components and Systems (United States)

    Stoltzfus, Joel; Sparks, Kyle


    Fire hazards are inherent in oxygen systems and a storied history of fires in rocket engine propulsion components exists. To detect and mitigate these fire hazards requires careful, detailed, and thorough analyses applied during the design process. The oxygen compatibility assessment (OCA) process designed by NASA Johnson Space Center (JSC) White Sands Test Facility (WSTF) can be used to determine the presence of fire hazards in oxygen systems and the likelihood of a fire. This process may be used as both a design guide and during the approval process to ensure proper design features and material selection. The procedure for performing an OCA is a structured step-by-step process to determine the most severe operating conditions; assess the flammability of the system materials at the use conditions; evaluate the presence and efficacy of ignition mechanisms; assess the potential for a fire to breach the system; and determine the reaction effect (the potential loss of life, mission, and system functionality as the result of a fire). This process should be performed for each component in a system. The results of each component assessment, and the overall system assessment, should be recorded in a report that can be used in the short term to communicate hazards and their mitigation and to aid in system/component development and, in the long term, to solve anomalies that occur during engine testing and operation.

  9. [Safety and electromagnetic compatibility in sanitary field]. (United States)

    Bini, M; Feroldi, P; Ferri, C; Ignesti, A; Olmi, R; Priori, S; Riminesi, C; Tobia, L


    In sanitary field and especially in a hospital, multiple sources of non ionizing radiation are used for diagnostic and therapeutic aims. In sanitary sector both workers and users are present at the same time, and in some cases general population could need higher protection than workers in relationship to the exposition to electromagnetic fields. In order to protect health and safety of patients, general population and workers of hospitals and with the aim to identify, analyze, evaluate and study its level of significance, electrical, magnetic and electromagnetic sources Research Italian project Si.C.E.O. (Safety And Electromagnetic Compatibility In Sanitary Field) was instituted. Target of our research project was to deepen risk of exposition elements with analysis of outdoor (e.g. power lines, transmission cabinets) and indoor (e.g. equipment for physical therapy) sources, located in sanitary structures and to verify the level exposition of workers and common population end the respect of specific regulation, and finally to define technical and organizational measures really useful for protection and reduction of risk.

  10. Estimation of Most Favorable Optical Window Position Subject to Achieve Finest Optical Control of Lateral DDR IMPATT Diode Designed to Operate at W-Band

    Directory of Open Access Journals (Sweden)

    A. Acharyya


    Full Text Available The optimum position of the optical window (OW of illuminated lateral double-drift region (DDR impact avalanche transit time (IMPATT device has been determined subject to achieve the finest optical control of both DC and RF properties of the device. The OW is a tiny hole that has to be created on the oxide layer through which the light energy of appropriate wavelength can be coupled to the space charge region of the device. A non-sinusoidal voltage is assumed to be applied across the diode and the corresponding terminal current response is obtained from a two-dimensional (2-D large-signal (L-S simulation technique developed by the authors for illuminated lateral DDR IMPATT diode. Both the DC and L-S properties of the illuminated device based on Si, designed to operate at W-band frequencies (75 – 110 GHz are obtained from the said L-S simulation. Simulation is carried out for different incident optical power levels of different wavelengths (600 – 1000 nm by varying the position of the fixed sized OW on the oxide layer along the direction of electrical conduction of the device. Results show that, the most favorable optical tuning can be achieved when the OW is entirely created over the p-type depletion layer, i.e. when the photocurrent is purely electron dominated. Also the 700 nm wavelength is found to be most suitable wavelength for obtaining the maximum optical modulation of both DC and RF properties of the device.

  11. 47 CFR 68.4 - Hearing aid-compatible telephones. (United States)


    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Hearing aid-compatible telephones. 68.4 Section... (CONTINUED) CONNECTION OF TERMINAL EQUIPMENT TO THE TELEPHONE NETWORK General § 68.4 Hearing aid-compatible... for export) or imported for use in the United States after August 16, 1989, must be hearing...

  12. 47 CFR 68.414 - Hearing aid-compatibility: Enforcement. (United States)


    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Hearing aid-compatibility: Enforcement. 68.414... (CONTINUED) CONNECTION OF TERMINAL EQUIPMENT TO THE TELEPHONE NETWORK Complaint Procedures § 68.414 Hearing aid-compatibility: Enforcement. Enforcement of §§ 68.4 and 68.112 is hereby delegated to those...

  13. 14 CFR 36.3 - Compatibility with airworthiness requirements. (United States)


    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Compatibility with airworthiness requirements. 36.3 Section 36.3 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Compatibility with airworthiness requirements. It must be shown that the aircraft meets the...

  14. 47 CFR 68.112 - Hearing aid-compatibility. (United States)


    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Hearing aid-compatibility. 68.112 Section 68.112 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED... Hearing aid-compatibility. (a) Coin telephones. All new and existing coin-operated telephones,...

  15. 42 CFR 493.863 - Standard; Compatibility testing. (United States)


    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard; Compatibility testing. 493.863 Section 493.863 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN..., Or Any Combination of These Tests § 493.863 Standard; Compatibility testing. (a) Failure to attain...

  16. 36 CFR 1193.21 - Accessibility, usability, and compatibility. (United States)


    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Accessibility, usability, and compatibility. 1193.21 Section 1193.21 Parks, Forests, and Public Property ARCHITECTURAL AND TRANSPORTATION... Accessibility, usability, and compatibility. Where readily achievable, telecommunications equipment and...

  17. 14 CFR 25.941 - Inlet, engine, and exhaust compatibility. (United States)


    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Inlet, engine, and exhaust compatibility. 25.941 Section 25.941 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF..., engine, and exhaust compatibility. For airplanes using variable inlet or exhaust system geometry, or...

  18. 46 CFR 154.552 - Cargo hose: Compatibility. (United States)


    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo hose: Compatibility. 154.552 Section 154.552 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SAFETY... Hose § 154.552 Cargo hose: Compatibility. Liquid and vapor cargo hoses must: (a) Not chemically...

  19. Morphology and Compatibility of Compatibilized Polyethersulfone and Polycarbonate Blends

    Institute of Scientific and Technical Information of China (English)

    SUN Xiao-bo; JIANG Dong; WU Wei-chun; JIANG Zhen-hua


    A PES-PC(polyethersulfone-polycarbonate) multi block random copolymer was synthesized with two oligomers, polyethersulfone and polycarbonate. The effects of the copolymer, as a compatibilizer, on the morphology and compatibility of the PES-PC blends were investigated. It was found that the addition of this copolymer to the PES-PC blends could improve their compatibility.

  20. Graph Triangulations and the Compatibility of Unrooted Phylogenetic Trees

    CERN Document Server

    Vakati, Sudheer


    We characterize the compatibility of a collection of unrooted phylogenetic trees as a question of determining whether a graph derived from these trees --- the display graph --- has a specific kind of triangulation, which we call legal. Our result is a counterpart to the well known triangulation-based characterization of the compatibility of undirected multi-state characters.

  1. CMOS-compatible LVOF-based visible microspectrometer

    NARCIS (Netherlands)

    Emadi, A.; Wu, H.; De Graaf, G.; Wolffenbuttel, R.F.


    This paper reports on a CMOS-Compatible Linear Variable Optical Filter (LVOF) visible micro-spectrometer. The CMOS-compatible post process for fabrication of the LVOF has been used for integration of the LVOF with a CMOS chip containing a 128-element photodiode array and readout circuitry. Fabricati

  2. Brain-Compatible Music Teaching Part 2: Teaching "Nongame" Songs (United States)

    Kenney, Susan


    In the previous issue of "General Music Today," the Early Childhood column explored brain-compatible ways of teaching action songs and singing games. This article illustrates the application of brain-compatible ways to teach songs that do not lend themselves to actions or games. There are two ways of teaching songs. One is based on the assumption…

  3. 47 CFR 76.630 - Compatibility with consumer electronics equipment. (United States)


    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Compatibility with consumer electronics equipment. 76.630 Section 76.630 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST... Compatibility with consumer electronics equipment. (a) Cable system operators shall not scramble or...

  4. Impact of compatibility on the organization of mutualistic networks. (United States)

    Maeng, Seong Eun; Lee, Jae Woo; Lee, Deok-Sun


    Distinct relationships such as activation, inhibition, cooperation, and competition are not established independently but in a correlated manner in complex systems. Thus the patterns of one type of interaction may reflect the impacts of other classes of interactions, but its quantitative understanding remains to be done. Referring to the plant-pollinator mutualistic networks, here we propose and investigate the structural features of a model bipartite network, in which the mutualistic relationship between two different types of nodes is established under the influence of the compatibility among the nodes of the same type. Interestingly, we find that the degree distributions obtained for extremely broad compatibility distributions are similar to those for a constant compatibility, both of which deviate from those for the Gaussian compatibility distributions. We present the analytic arguments to explain this finding. Also the dependence of the topological similarity of two nodes on their compatibility is illustrated. We discuss the application of our findings to complex systems.

  5. Determining Compatibilities of Reactive Dyes in Pad Dyeing

    Institute of Scientific and Technical Information of China (English)



    Compatibilities of reactive dyes were conventionally shown by exhausting curves. But the change of proportion of dyes in padding dyebath was difficult for pad dyeing to be described by these curves. In this paper, a kind of simulation of pad dyeing process was used to determine dyestuff compatibility in pad dyeing for ramie and linen fabrics. Seven reactive dyes were divided into three groups and tested., The group with Cibacron Yellow C - 2R, Red C - R, and Blue C - R showed very good compatibility both for ramie and linen,and the other two groups of dyes gave out correspondingly low compatibilities in the pad dyeing tests. The results of the method for determining the compatibility of dyes displayed good consistency with the actul pad dyeing process.

  6. Characterization of an Auto-Compatible Default Theory

    Institute of Scientific and Technical Information of China (English)

    XU DaoYun(许道云); DING DeCheng(丁德成); ZHANG MingYi(张明义)


    In this paper, an equivalence condition for deciding whether a default theory isan auto-compatible default one is presented. Under the condition, the existence of extension of anauto-compatible default theory is a natural result. By introducing a well-ordering over the set D ofdefault rules, the extensions of an auto-compatible default theory (D, W) can be computed directly.The condition represents clearly the characterization of an auto-compatible default theory, andsome properties about auto-compatible default theory, such as semi-monotonicity, become naturalcorollaries. Based on the characterization, the revision of default beliefs is discussed to ensure theexistence of extension of the default theory, and the method is applied to investigate stable modelsof a general logic program.

  7. Compatibility of Fluorinert, FC-72, with selected materials.

    Energy Technology Data Exchange (ETDEWEB)

    Aubert, James Henry; Sawyer, Patricia Sue


    Removable encapsulants have been developed as replacement materials for electronic encapsulation. They can be removed from an electronic assembly in a fairly benign manner. Encapsulants must satisfy a limited number of criteria to be useful. These include processing ease, certain mechanical, thermal, and electrical properties, adhesion to common clean surfaces, good aging characteristics, and compatibility. This report discusses one aspect of the compatibility of removable blown epoxy foams with electronic components. Of interest is the compatibility of the blowing agent, Fluorinert{trademark} (FC-72) electronic fluid with electronic parts, components, and select materials. Excellent compatibility is found with most of the investigated materials. A few materials, such as Teflon{reg_sign} that are comprised of chemicals very similar to FC-72 show substantial absorption of FC-72. No compatibility issues have yet been identified even for the few materials that show substantial absorption.

  8. Deformation compatibility control for engineering structures methods and applications

    CERN Document Server

    Zhu, Hanhua; Chen, Mengchong; Deng, Jianliang


    This book presents essential methods of deformation compatibility control, and explicitly addresses the implied conditions on the methods’ deformation compatibility. Consequently, these conditions can be considered in engineering structure design, while the conditions on stable equilibrium can be taken into account in the design method. Thus, the designed deformation and the actual deformation of the respective structure are approximately identical, guaranteeing both the flexibility of the construction material in force transmission and the equilibrium of force in the structure. Though equilibrium theory in engineering structures has been extensively studied, there has been comparatively little research on compatibility. In the limited researches available, the topics are primarily the theories and assumptions on the deformation compatibility, while few systematic works focus on the mechanical theoretical principles and methods of deformation compatibility control. As such, the flexibility of the constructi...

  9. Inheritance of self-compatibility in almond: breeding strategies to assure self-compatibility in the progeny. (United States)

    Ortega, E; Dicenta, F


    To assure self-compatibility in the progenies, three different crosses were conducted for the first time in an almond breeding programme: self-pollination (266 descendants from 30 families), crosses between parents sharing an S-allele (108 descendants from five families) and crosses with homozygous self-compatible parents (62 descendants from five families). Depending on the cross, self-compatibility in the progenies was determined by observing pollen tube growth (by means of fluorescence microscopy), stylar S-RNases analysis or allele-specific PCR. The results obtained fit with the accepted hypothesis of inheritance of self-compatibility and the three crossing strategies used ensured 100% of self-compatible descendants. These strategies increase the efficiency of the breeding programme and avoid the laborious task of evaluating this characteristic. From the breeding point of view, self-fertilisation and crosses between relatives tend to produce inbreeding. Furthermore, these methods reduce the possibilities of choosing the parental combination. The use of homozygous self-compatible parents does not have any of these disadvantages. As far as we know, this is the first time that allele-specific PCR has been used for early selection of self-compatible seedlings. The advantages and disadvantages of the three methodologies used to determine self-compatibility are discussed.

  10. The Electromagnetic Compatibility Research Group: research questions

    Directory of Open Access Journals (Sweden)

    Francisco José Román Campos


    Full Text Available This paper summarises the Universidad Nacional de Colombia’s Electrical and Electronic Engineering Department’s Electromag- netic Compatibility Research Group (EMC-UNC activities during the last 30 years. The group was involved in developing experimental tools during the early 1980s, such as constructing high-voltage apparatus, developing high-voltage practical work for students and observing electrical discharges. These tools enabled the group to spend a decade focused on resolving one of the Colombian electrical sector’s main EMC problems: distribution transformer’s failures caused by lightning. For almost a decade this investigation was focused on understanding the causes of the extremely high failure index in Colombian rural areas, especially in the Rionegro basin. The main result of this investigation was a reduction by one order of magnitude in mean 10% distribution transformer failure rate. During this research work a noticeable pattern was observed of several electrically-isolated me- tallic bodies immersed in an electric field (i.e. floating electrodes. This was led to initiating floating electrode studies and for mulating a new scientific question, “How do corona electrical discharges interact with floating electrodes?” This new research question was dealt with during the second half of the 1990s and the first decade of the 2000s. This investigation was related to using electrostatically-accumulated charge on a floating electrode. This question opened up four research areas: gas discharge physics, generating fast current impulses, harvesting energy from the electric field and the possibility of high impedance current sources. This paper has summarised the most relevant work done by the EMC-UNC group on these topics. This floating electrode research work started by formulating four patents. Fresh research questions for the 2010s were related to measuring lightning electromagnetic pulses (LEMP, intentional electromagnetic

  11. Automatic imitation? Imitative compatibility affects responses at high perceptual load. (United States)

    Catmur, Caroline


    Imitation involves matching the visual representation of another's action onto the observer's own motor program for that action. However, there has been some debate regarding the extent to which imitation is "automatic"-that is, occurs without attention. Participants performed a perceptual load task in which images of finger movements were presented as distractors. Responses to target letter stimuli were performed via finger movements that could be imitatively compatible (requiring the same finger movement) or incompatible with the distractor movements: In this common stimulus-response compatibility manipulation, the stimulus set comprises images of the response movements, producing an imitative compatibility effect. Attention to the distractor movements was manipulated by altering perceptual load through increasing the number of nontarget letter stimuli. If imitation requires attention, then at high perceptual load, imitative compatibility should not affect response times. In contrast, imitative compatibility influenced response times at high perceptual load, demonstrating that distractor movements were processed. However, the compatibility effect was reversed, suggesting that longer response times at high perceptual load tap into an inhibitory stage of distractor movement processing. A follow-up experiment manipulating temporal delay between targets and distractor movements supported this explanation. Further experiments confirmed that nonmovement distractor stimuli in the same configuration produced standard perceptual load effects and that results were not solely due to effector compatibility. These data suggest that imitation can occur without attention. (PsycINFO Database Record

  12. The compatibility of fingerprint visualization techniques with immunolabeling. (United States)

    van Dam, Annemieke; Aalders, Maurice C G; van Leeuwen, Ton G; Lambrechts, Saskia A G


    The chemical composition of a fingermark potentially holds a wealth of information about the fingermark donor, which can be extracted by immunolabeling. Immunolabeling can be used to detect specific components in fingermarks; however, to be applicable in the forensic field, it should be compatible with commonly used fingerprint visualization techniques. In this study, the compatibility of immunolabeling with two different fingerprint visualization techniques, magnetic powdering and ninhydrin staining, was investigated on fingermarks deposited on glass and on nitrocellulose membranes. With dermcidin as antigen of interest, immunolabeling was performed successfully on all developed fingermarks. We can conclude that immunolabeling is compatible with magnetic powdering and ninhydrin staining, which can be of great forensic value.


    Institute of Scientific and Technical Information of China (English)

    ZHANG Xiaoqing; QIU Lingshi; WANG Dongsheng; WANG Yuanshen


    A 300MHz solid NMR study on the compatibility of ACR (poly (methyl methacrylate-co-methacrylate),in the ratio of 1:1)-PVC (poly (vinyl chloride)) blends is reported. Spin-lattice (T1) and spin-spin (T2)relaxation time of ACR, PVC and their blends are recorded in the temperature range from 215K to 355K.Experimental results indicate that ACR and PVC are compatible with each other and the domain size is smaller than 25 nm, but heterogeneities of molecular dimensions still exist. Some problems of mechanism of compatibility and data analysis are also discussed.

  14. Compatibility of Soybean Protein and Poly (vinyl alcohol)

    Institute of Scientific and Technical Information of China (English)

    沈婕; 肖茹; 顾利霞


    Bicomponent fibers were wet-spun from soybean protein and poly (vinyl alcohol). The fiber was brittle and showed a high frequency of breakage upon drawing and the bad compatibility between soybean protein and poly (vinyl alcohol) was thought to be the causes for the poor drawability. Our effort was then to study the soybean protein and poly (vinyl alcohol) solution, with the aim of trying to improve the components' compatibility and to determine the proper solution condition for dissolving them.The effects of alkali, sodium sulfite and urea on the compatibility of the solution were examined.


    Institute of Scientific and Technical Information of China (English)

    Li Lei; Niu Zhisheng


    A spatial compatible user grouping algorithm is proposed to reduce CoChannel Interference (CCI) in Space Division Multiple Access (SDMA) multiuser Multiple Input Multiple Output (MIMO)systems. We evaluate the interferences among users by use of distances between row spaces spanned by users' channel matrixes, then control frequency sharing according to the compatible user grouping algorithm. Results show that the row space distance algorithm outperforms others because it can fully utilize the information from users' channel matrixes, especially the matrix structure information. The results also prove that the algorithm based on channel matrix structure analysis is a better candidate for spatial compatibility approximation.

  16. Investigation of the Compatibility Between ADS Target Material With Coolant

    Institute of Scientific and Technical Information of China (English)


    At present, the program of the compatibility study on ADS project of China Institute of Atomic Energy is focused on the compatibility tests for the tungsten with water and sodium. An ADS verification facility is proposed in next phase of ADS project, an existent swimming pool reactor will be repack as the subcritical reactor system, and tungsten will be used as the target. On the other hand, our CEFR is being constructed now, it may be one of the options as the subcritical reactor system of ADS, thus, it is necessary to understand the compatibility characteristics of tungsten with sodium and water.

  17. [Florida Panther National Wildlife Refuge: Comprehensive Conservation Plan]: Compatibility Determination (United States)

    US Fish and Wildlife Service, Department of the Interior — This document states that the actions proposed in the 2000 Florida Panther NWR Comprehensive Conservation Plan are compatible with Refuge goals.

  18. Compatibility Determination : Hunting of migratory birds and resident game (United States)

    US Fish and Wildlife Service, Department of the Interior — This is the Compatibility Determination for the Minnesota Valley NWR and WMD proposed Hunting Plan. Refuge purposes are outlined and proposed hunting activities are...


    Institute of Scientific and Technical Information of China (English)

    XIAO Fengfei; ZHANG Xian; HU Shiru; MA Dezhu; LUO Xiaolie; XU Mao


    Blends of PVC and polyurethanes with four different soft segments of molecular weight 1000 were prepared and studied by dynamic mechanical and DSC techniques. It was found that the compatibility of PVC with segmented polyurethanes was related to the mixing of PVC molecules and the soft segments of the polyurethanes. Polyester based polyurethanes are more compatible with PVC than polyether based polyurethanes. Solution cast blends of PVC with PCL-polyurethane (1/2/1) exhibit single and narrow glass transition, while the blends with PPO-polyurethane (1/2/1) are completely incompatible. The compatibility was found to decrease with increasing hard segment content for all the polyurethanes used. The methods of blend preparation may change the compatibility of PVC/PU blends through their influence on the mixing or demixing of the hard and soft segments.

  20. Optical glass compatibility for the design of apochromatic systems

    Directory of Open Access Journals (Sweden)

    Gruescu C.


    Full Text Available The design of apochromatic systems is difficult because of two problems: the glass sorts compatibility and the c1/ca arbitrary input ratio. The optical glass manufacturers offer a wide range of sorts, so that the choice of triplet compatible glasses becomes itself an important separate problem. The paper provides a solution of mathematical modeling for the glass compatibility and, practically, analyses the sorts presented by Schott GmbH. The original software provided 22 compatible glass triplets. The authors explored the possibilities of enlarging the c1/ca ratio from the value 0.6 indicated in the literature to a range of [0.5…0.8]. Therefore, they designed and analyzed a set of 88 triplets. A correct glass choice can insure twice-larger apertures than the traditional ones for best quality apochromats (diffraction-limited.

  1. Strain compatibility assessment for SRB sprayable ablator MSA-1 (United States)

    Patterson, W. J.


    Tensile and compressive strain compatibility testing was performed on as-sprayed samples of the Shuttle Solid Rocket Booster external ablator material, MSA-1. Strain gages on the aluminum substrate were used to monitor strain. Strain compatibility was determined as the percent strain in the substrate at first visual evidence of MSA-1 failure. The 1/8-in. MSA-1, baselined for large areas of the SRB external skin, was characterized by a strain compatibility of 1.5 to 1.8 percent, which far exceeded the yield range of the metal substrate. Thicker MSA-1 applications (1.4 to 3/8 in.) were characterized by a lower level of strain compatibility, which appeared to be a manifestation of application limitations.

  2. Nonclassical Symmetries for Nonlinear Partial Differential Equations via Compatibility

    Institute of Scientific and Technical Information of China (English)

    Mostafa F. El-Sabbagh; Ahmad T. Ali


    The determining equations for the nonclassical symmetry reductions of nonlinear partial differential equations with arbitrary order can be obtained by requiring the compatibility between the original equations and the invariant surface conditions. The (2+1)-dimensional shallow water wave equation, Boussinesq equation, and the dispersive wave equations in shallow water serve as examples i11ustrating how compatibility leads quickly and easily to the determining equations for their nonclassical symmetries.

  3. Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer. (United States)

    Menendez, Javier A; Cufí, Sílvia; Oliveras-Ferraros, Cristina; Martin-Castillo, Begoña; Joven, Jorge; Vellon, Luciano; Vazquez-Martin, Alejandro


    By activating the ataxia telangiectasia mutated (ATM)-mediated DNA Damage Response (DDR), the AMPK agonist metformin might sensitize cells against further damage, thus mimicking the precancerous stimulus that induces an intrinsic barrier against carcinogenesis. Herein, we present the new hypothesis that metformin might function as a tissue sweeper of pre-malignant cells before they gain stem cell/tumor initiating properties. Because enhanced glycolysis (the Warburg effect) plays a causal role in the gain of stem-like properties of tumor-initiating cells by protecting them from the pro-senescent effects of mitochondrial respiration-induced oxidative stress, metformin's ability to disrupt the glycolytic metabotype may generate a cellular phenotype that is metabolically protected against immortalization. The bioenergetic crisis imposed by metformin, which may involve enhanced mitochondrial biogenesis and oxidative stress, can lower the threshold for cellular senescence by pre-activating an ATM-dependent pseudo-DDR. This allows an accelerated onset of cellular senescence in response to additional oncogenic stresses. By pushing cancer cells to use oxidative phosphorylation instead of glycolysis, metformin can rescue cell surface major histocompatibility complex class I (MHC-I) expression that is downregulated by oncogenic transformation, a crucial adaptation of tumor cells to avoid the adaptive immune response by cytotoxic T-lymphocytes (CTLs). Aside from restoration of tumor immunosurveillance at the cell-autonomous level, metformin can activate a senescence-associated secretory phenotype (SASP) to reinforce senescence growth arrest, which might trigger an immune-mediated clearance of the senescent cells in a non-cell-autonomous manner. By diminishing the probability of escape from the senescence anti-tumor barrier, the net effect of metformin should be a significant decrease in the accumulation of dysfunctional, pre-malignant cells in tissues, including those with the

  4. Backward compatibility effects in younger and older adults. (United States)

    Hartley, Alan A; Maquestiaux, François; Festini, Sara B; Frazier, Kathryn; Krimmer, Patricia J


    In many dual-task situations, responses to the second of two tasks are slowed when the time between tasks is short. The response-selection bottleneck model of dual-task performance accounts for this phenomenon by assuming that central processing of the second task is blocked by a bottleneck until central processing of Task 1 is complete. This assumption could be called into question if it could be demonstrated that the response to Task 2 affected the central processing of Task 1, a backward response compatibility effect. Such effects are well-established in younger adults. Backward compatibility effects in older (as well as younger) adults were explored in two experiments. The first experiment found clear backward response compatibility effects for younger adults but no evidence of them for older adults. The second experiment explored backward stimulus compatibility and found similar effects in both younger and older adults. Evidence possibly consistent with some pre-bottleneck processing of Task 2 central stages also was found in the second experiment in both age groups. For younger adults, the results provide further evidence falsifying the claim of an immutable response selection bottleneck. For older adults, the evidence suggested that Task 2 affects Task 1 when there is stimulus compatibility but not when there is response compatibility.

  5. 75 FR 70241 - Compatibility of Underground Storage Tank Systems With Biofuel Blends (United States)


    ... AGENCY Compatibility of Underground Storage Tank Systems With Biofuel Blends AGENCY: Environmental... tank (UST) compatibility requirement as it applies to UST systems storing gasoline containing greater... underground storage tank systems greater clarity in demonstrating compatibility of their tank systems...

  6. Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans. (United States)

    Carroll, Judith E; Cole, Steven W; Seeman, Teresa E; Breen, Elizabeth C; Witarama, Tuff; Arevalo, Jesusa M G; Ma, Jeffrey; Irwin, Michael R


    Age-related disease risk has been linked to short sleep duration and sleep disturbances; however, the specific molecular pathways linking sleep loss with diseases of aging are poorly defined. Key cellular events seen with aging, which are thought to contribute to disease, may be particularly sensitive to sleep loss. We tested whether one night of partial sleep deprivation (PSD) would increase leukocyte gene expression indicative of DNA damage responses (DDR), the senescence-associated secretory phenotype (SASP), and senescence indicator p16(INK4a) in older adult humans, who are at increased risk for cellular senescence. Community-dwelling older adults aged 61-86years (n=29; 48% male) underwent an experimental partial sleep deprivation (PSD) protocol over 4 nights, including adaptation, an uninterrupted night of sleep, partial sleep deprivation (sleep restricted 3-7AM), and a subsequent full night of sleep. Blood samples were obtained each morning to assess peripheral blood mononuclear cell (PBMC) gene expression using Illumina HT-12 arrays. Analyses of microarray results revealed that SASP (psleep deprivation activates PBMC gene expression patterns consistent with biological aging in this older adult sample. PSD enhanced the SASP and increased the accumulation of damage that initiates cell cycle arrest and promotes cellular senescence. These findings causally link sleep deprivation to the molecular processes associated with biological aging.

  7. Medical research on environment and public health in the German Democratic Republic (1949-1989). A critical analysis of the literature; Umweltmedizinische Arbeiten aus der DDR-Zeit (1949-1989). Eine kritische Literaturanalyse

    Energy Technology Data Exchange (ETDEWEB)

    Klemm, P.G.


    Research on environmental health and environmental epidemiology was in the former GDR restricted and only possible under difficult conditions. The DDR-Officials did not want to acknowledge any existing environmental problems, they put their emphasis on the domestic economy. The aim of environmental research was to analyze the strongest effects on human health so that the running production was not jeopardized. Despite these restrictions a considerable number of studies exists which were published in scientific journals, internal reports or as theses. Results of these studies were only made accessible to the public and scientistis after the political officials gave their approval. Unfavourable results were withheld. In 1989 before the German unification the former German-German Commission on questions of environmental health started to collect these documents as a basis for a systematic evaluation of the literature on enrironment and health in the GDR. This evaluation was never carried out. After the unification the Author. (orig./VHE) [Deutsch] Umweltmedizinische und umweltepidemiologische Forschung war in der DDR nur unter schwierigen Randbedingungen moeglich. Dies lag im Selbstverstaendnis der DDR-Fuehrung begruendet, die der Oekonomie absoluten Vorrang vor der Oekologie gab. Umweltmedizinische Forschung hatte dabei die Aufgabe, gravierende umweltbedingte Wirkungen auf die menschliche Gesundheit im Vorfeld zu analysieren, um die laufende Produktion nicht zu gefaehrden. Deswegen kommt eine ansehnliche Zahl von Untersuchungen zusammen, die als wissenschaftliche Arbeiten publiziert wurden sowie als Forschungsberichte und Dissertationen vorliegen. Allerdings wurden die nach Einschaetzung der politischen Fuehrung und der wissenschaftlichen Administration umweltpolitisch brisanten Ergebnisse per Ministerratsbeschluss sowohl der Oeffentlichkeit vorenthalten als auch dem interessierten Fachwissenschaftler. Der zunehmenden Umweltbelastung und dem steigenden oeffentlichen

  8. Compatibility and sex in a snail-schistosome system. (United States)

    Webster, J P


    Knowledge of the genetics underlying resistance to parasitic infection has important repercussions for our understanding of infection dynamics and the mechanisms of host-parasite co-evolution. The aim here was to determine for a Biomphalaria glabrato-Schistosoma mansoni system whether (1) resistance is dominant over susceptibility, (2) it is possible to crossbreed snails to be simultaneously resistant and/or susceptible to more than one parasite strain and (3) compatibility genotype affects reproductive strategy. Using replicate snail strains artificially selected for either resistance or susceptibility to single replicate parasite strains, individual snails from each line were paired with a selected partner of matched or non-matched compatibility status and cross-breeding was identified by RAPD-PCR. The resulting compatibility phenotype of all offspring was determined. Support for all 3 hypotheses were obtained. The results are discussed in terms of their applied and theoretical implications.

  9. Compatibility of novel blends from polyolefin and coal

    Institute of Scientific and Technical Information of China (English)

    YANG Fu-sheng(杨伏生); ZHOU An-ning(周安宁)


    Melt blends of low-density polyethylene(LDPE), ethylene vinyl acetate(EVA) and coal with various compositions were prepared through reactive extrusion. The rheological behaviour was studied with respect to the effect of blend ratio, shear rate using a rheometer to gain an understanding of processing parameters controlling industrial application. Compatibility was also evaluated by differential scanning calorimetry(DSC) and scanning electron microscopy(SEM). The results revealed that LDPE/EVA/coal is a partly compatible system showing pseudo-plastic behaviour, increase in viscosity with increased coal content appeares evident only at low shear rate region, viscosity tends to keep consistent approximately but irrelates to coal content at higher shear rate. Blends viscosity and compatibility are attibuted to changes in LDPE crystalline structure and entanglement, together with interaction between macromolecular aliphatic chains in coal and amorphous phase in LDPE and EVA at the boundaries of phases, which comes forth during the rearrangement process of the crystalline structure.

  10. The Compatibility in Optic Fiber Smart Concrete and Structure

    Institute of Scientific and Technical Information of China (English)


    The compatibility between a fiber optical sensor and concrete structure in the optic fiber smart concrete is studied.The methods of improving the compatibility are proposed based on theory analysing, and a novel fiber optical sensor was developed. The experimental results show that the novel structure of fiber optical sensor and the scheme of the protecting layer of epoxy resin bed composite not only enable the sensor to be applied in strict environment, but also can monitor the beginning propagation and breaking of concrete cracks. The results also indicate that the sensor will maintain its properties in the case of large deformation and that it has the high compatibility with concrete structure and can meet special needs of the intelligent materials and structure.

  11. Compatibility of repair mortar with migrating corrosion inhibiting admixtures

    Energy Technology Data Exchange (ETDEWEB)

    Bjegovic, D.; Ukrainczyk, V. [Univ. of Zagreb (Croatia). Faculty of Civil Engineering; Ukrainczyk, B. [LGM, Zagreb (Croatia); Miksic, B. [CORTEC Corp., St. Paul, MN (United States)


    One of the methods for corrosion protection of reinforced concrete is the use of migrating corrosion inhibitor as an admixture in repair mortars. The admixture must be effective for corrosion protection and compatible with polymers added to repair mortar to improve properties of fresh and hardened mortar. This paper presents experimental results on compatibility of a migrating corrosion inhibitor added to two repair mortars based on an inorganic binder modified with polymers. The influence of a migrating inhibitor on the properties of fresh and hardened mortars was tested. The effectiveness on reinforcement corrosion protection has been tested according to ASTM G 109. Test results prove that the investigated migrating inhibitor is compatible with repair mortars and that it delays corrosion of the reinforcement.

  12. Monolithic CMOS-compatible zero-index metamaterials

    CERN Document Server

    Vulis, Daryl I; Reshef, Orad; Camayd-Muñoz, Philip; Yin, Mei; Kita, Shota; Lončar, Marko; Mazur, Eric


    Zero-index materials exhibit exotic optical properties that can be utilized for integrated-optics applications. However, practical implementation requires compatibility with complementary metallic-oxide-semiconductor (CMOS) technologies. We demonstrate a CMOS-compatible zero-index metamaterial consisting of a square array of air holes in a 220-nm-thick silicon-on-insulator (SOI) wafer. This design is achieved through a Dirac-cone dispersion. The metamaterial is entirely composed of silicon and offers compatibility through low-aspect-ratio structures that can be simply fabricated in a standard device layer. This platform enables mass adoption and exploration of zero-index-based photonic devices at low cost and high fidelity.

  13. Compatibility and kidney transplantation: the way to go. (United States)

    Doxiadis, Ilias I N


    Long lasting debates in the past questioned the relevance of any sort of compatibility in post mortal kidney transplantation. It is for no say that fully compatible transplants have the highest chances for a long patient and graft survival. In the present report the use of HLA-DR as a representative of the Major Histocompatibility Complex class II genes in the allocation of organs is discussed. The major arguments are the easiness to offer to patients a compatible graft in a relatively short waiting time, an increase in graft survival, the less sensitization during the transplantation period, and the lower waiting time for a retransplant. Even if the number of organ donors remains the same a lowering of the mean waiting time is expected because of the longer period of graft survival.

  14. Technical compatibility and safety of glass fiber in battery separators

    Energy Technology Data Exchange (ETDEWEB)

    Bender, R. [Schuller International, Toledo, OH (United States); Versen, R. [Schuller International, Littleton, CO (United States)


    Nonwovens comprised of glass fibers are both compatible with the relatively harsh chemical environment in lead acid batteries, and yet are safe to handle. The health and safety of glass fibers may seem confusing from a regulatory viewpoint, but are in fact highly tested and well understood scientifically to not cause respiratory disease. Nonwoven separators made from glass fibers are well situated to withstand scientific scrutiny in these times of suspicion of negative health effects ranging from second-hand smoke to tap water. This paper examines technical compatibility of the glass fibers in the battery, the health and safety aspects of glass fibers, and governmental and regulatory interpretation of studies.

  15. CMOS-compatible photonic devices for single-photon generation

    Directory of Open Access Journals (Sweden)

    Xiong Chunle


    Full Text Available Sources of single photons are one of the key building blocks for quantum photonic technologies such as quantum secure communication and powerful quantum computing. To bring the proof-of-principle demonstration of these technologies from the laboratory to the real world, complementary metal–oxide–semiconductor (CMOS-compatible photonic chips are highly desirable for photon generation, manipulation, processing and even detection because of their compactness, scalability, robustness, and the potential for integration with electronics. In this paper, we review the development of photonic devices made from materials (e.g., silicon and processes that are compatible with CMOS fabrication facilities for the generation of single photons.

  16. Compatible finite element spaces for geophysical fluid dynamics

    CERN Document Server

    Natale, Andrea


    Compatible finite elements provide a framework for preserving important structures in equations of geophysical fluid dynamics, and are becoming important in their use for building atmosphere and ocean models. We survey the application of compatible finite element spaces to geophysical fluid dynamics, including the application to the nonlinear rotating shallow water equations, and the three-dimensional compressible Euler equations. We summarise analytic results about dispersion relations and conservation properties, and present new results on approximation properties in three dimensions on the sphere, and on hydrostatic balance properties.

  17. Is equal moral consideration really compatible with unequal moral status? (United States)

    Rossi, John


    The issue of moral considerability, or how much moral importance a being's interests deserve, is one of the most important in animal ethics. Some leading theorists--most notably David DeGrazia--have argued that a principle of "equal moral consideration" is compatible with "unequal moral status." Such a position would reconcile the egalitarian force of equal consideration with more stringent obligations to humans than animals. The article presents arguments that equal consideration is not compatible with unequal moral status, thereby forcing those who would justify significantly different moral protections for humans and animals to argue for unequal consideration.

  18. CMOS-compatible photonic devices for single-photon generation (United States)

    Xiong, Chunle; Bell, Bryn; Eggleton, Benjamin J.


    Sources of single photons are one of the key building blocks for quantum photonic technologies such as quantum secure communication and powerful quantum computing. To bring the proof-of-principle demonstration of these technologies from the laboratory to the real world, complementary metal-oxide-semiconductor (CMOS)-compatible photonic chips are highly desirable for photon generation, manipulation, processing and even detection because of their compactness, scalability, robustness, and the potential for integration with electronics. In this paper, we review the development of photonic devices made from materials (e.g., silicon) and processes that are compatible with CMOS fabrication facilities for the generation of single photons.

  19. A Study of the Relationship of Student-Teacher Compatibility on Student Achievement in Algebra. (United States)

    Easterday, Kenneth E.; Paul, Oliver Daye


    Comparison of seven levels of student-teacher compatibility with student achievement found a positive significant relationship between total compatibility and compatibility in the personal need for inclusion with student achievement. Limited evidence was also found for a relationship between achievement and pupil-teacher compatibility in the…

  20. Pleiotropic effects of spongean alkaloids on mechanisms of cell death, cell cycle progression and DNA damage response (DDR) of acute myeloid leukemia (AML) cells. (United States)

    Stuhldreier, Fabian; Kassel, Stefanie; Schumacher, Lena; Wesselborg, Sebastian; Proksch, Peter; Fritz, Gerhard


    We investigated cytotoxic mechanisms evoked by the spongean alkaloids aaptamine (Aa) and aeroplysinin-1 (Ap), applied alone and in combination with daunorubicin, employing acute myeloid leukemia (AML) cells. Aa and Ap reduced the viability of AML cells in a dose dependent manner with IC50 of 10-20 µM. Ap triggered apoptotic cell death more efficiently than Aa. Both alkaloids increased the protein level of S139-phosphorylated H2AX (γH2AX), which however was independent of the induction of DNA damage. Expression of the senescence markers p21 and p16 was increased, while the phosphorylation level of p-Chk-2 was reduced following Aa treatment. As a function of dose, Aa and Ap protected or sensitized AML cells against daunorubicin. Protection by Aa was paralleled by reduced formation of ROS and lower level of DNA damage. Both Aa and Ap attenuated daunorubicin-stimulated activation of the DNA damage response (DDR) as reflected on the levels of γH2AX, p-Kap-1 and p-Chk-1. Specifically Ap restored the decrease in S10 phosphorylation of histone H3 resulting from daunorubicin treatment. The cytoprotective effects of Aa and Ap were independent of daunorubicin import/export. Both Aa and Ap abrogated daunorubicin-induced accumulation of cells in S-phase. Inhibition of DNA synthesis was specific for Ap. The data show that Aa and Ap have both congruent and agent-specific pleiotropic effects that are preferential for anticancer drugs. Since Ap showed a broader spectrum of anticancer activities, this compound is suggested as novel lead compound for forthcoming in vivo studies elucidating the usefulness of spongean alkaloids in AML therapy.

  1. Firo-B Interpersonal Compatibility: A Suggested Modification. (United States)

    Malloy, Thomas E.; Copeland, Ellis P.


    The Fundamental Interpersonal Relations Orientation Behavior (FIRO-B) scale is a measure of inclusion, control and affection. Examination of the component algorithms which yield its global compatibility score suggest an inconsistent use of absolute values and real numbers. A modification of Schutz's original mathematical schema is presented.…

  2. Stiffness compatibility of coralline hydroxyapatite bone substitute under dynamic loading

    Institute of Scientific and Technical Information of China (English)

    REN ChaoFeng; HOU ZhenDe; ZHAO Wei


    When hydroxyapatite bone substitutes are implanted in human bodies, bone tissues will grow into their porous structure, which will reinforce their strength and stiffness. The concept of mechanical com-patibility of bone substitutes implies that their mechanical properties are similar to the bone tissues around, as if they were part of the bone. The mechanical compatibility of bone substitutes includes both static and dynamic behavior, due to the mechanical properties of bone depending on the strain rate. In this study, split Hopkinson pressure bar technique (SHPB) was employed to determine the dy-namic mechanical properties of coralline hydroxyapatite, bones with and bones without organic com-ponents, and their dynamic stress-strain curves of the three materials were obtained. The mechanical effects of collagens in bone were assessed, by comparing the difference between the Young's moduli of the three materials. As the implanted bone substitute becomes a part of bone, it can be regarded as an inclusion composite. The effective modulus of the composite was also evaluated in order to estimate its mechanical compatibility on stiffness. The evaluated result shows that the suitable porosity of HA is0.8, which is in favor of both static and dynamic stiffness compatibility.

  3. 36 CFR 13.118 - Cabin site compatibility. (United States)


    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Cabin site compatibility. 13.118 Section 13.118 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Cabins General Provisions § 13.118 Cabin site...

  4. Time Course Analyses Confirm Independence of Imitative and Spatial Compatibility (United States)

    Catmur, Caroline; Heyes, Cecilia


    Imitative compatibility, or automatic imitation, has been used as a measure of imitative performance and as a behavioral index of the functioning of the human mirror system (e.g., Brass, Bekkering, Wohlschlager, & Prinz, 2000; Heyes, Bird, Johnson, & Haggard, 2005; Kilner, Paulignan, & Blakemore, 2003). However, the use of imitative…

  5. Stiffness compatibility of coralline hydroxyapatite bone substitute under dynamic loading

    Institute of Scientific and Technical Information of China (English)


    When hydroxyapatite bone substitutes are implanted in human bodies,bone tissues will grow into their porous structure,which will reinforce their strength and stiffness.The concept of mechanical com-patibility of bone substitutes implies that their mechanical properties are similar to the bone tissues around,as if they were part of the bone.The mechanical compatibility of bone substitutes includes both static and dynamic behavior,due to the mechanical properties of bone depending on the strain rate.In this study,split Hopkinson pressure bar technique(SHPB) was employed to determine the dy-namic mechanical properties of coralline hydroxyapatite,bones with and bones without organic com-ponents,and their dynamic stress-strain curves of the three materials were obtained.The mechanical effects of collagens in bone were assessed,by comparing the difference between the Young’s moduli of the three materials.As the implanted bone substitute becomes a part of bone,it can be regarded as an inclusion composite.The effective modulus of the composite was also evaluated in order to estimate its mechanical compatibility on stiffness.The evaluated result shows that the suitable porosity of HA is 0.8,which is in favor of both static and dynamic stiffness compatibility.

  6. Operation Compatibility: A Neglected Contribution to Dual-Task Costs (United States)

    Pannebakker, Merel M.; Band, Guido P. H.; Ridderinkhof, K. Richard


    Traditionally, dual-task interference has been attributed to the consequences of task load exceeding capacity limitations. However, the current study demonstrates that in addition to task load, the mutual compatibility of the concurrent processes modulates whether 2 tasks can be performed in parallel. In 2 psychological refractory period…

  7. Macromolecular unfolding properties in presence of compatible solutes

    CERN Document Server

    Smiatek, Jens; Heuer, Andreas


    We present Molecular Dynamics simulations of Chymotrypsin inhibitor II and PEO in presence of compatible solutes. Our results indicate that the the native compact state of the studied macromolecules is stabilized in presence of hydroxyectoine. We are able to explain the corresponding mechanism by a variation of the solvent properties for higher hydroxyectoine concentrations. Our results are validated by detailed free energy calculations.

  8. On a conjecture of compatibility of multi-states characters

    CERN Document Server

    Habib, Michel


    Perfect phylogeny consisting of determining the compatibility of a set of characters is known to be NP-complete. We propose in this article a conjecture on the necessary and sufficient conditions of compatibility: Given a set $\\mathcal{C}$ of $r$-states full characters, there exists a function $f(r)$ such that $\\mathcal{C}$ is compatible iff every set of $f(r)$ characters of $\\mathcal{C}$ is compatible. Some previous work showed that $f(2)=2$, $f(3)=3$ and $f(r) \\ge r-1$. Gusfield et al. 09 conjectured that $f(r) = r$ for any $r \\ge 2$. In this paper, we present an example showing that $f(4) \\ge 5$ and then a closure operation for chordal sandwich graphs. The later problem is a common approach of perfect phylogeny. This operation can be the first step to simplify the problem before solving some particular cases $f(4), f(5), ... $, and determining the function $f(r)$.

  9. Creative Commons licenses and design: are the two compatible?

    NARCIS (Netherlands)

    C. Jasserand


    This article analyses whether Creative Commons licences are applicable to and compatible with design. The first part focuses on the peculiar and complex nature of a design, which can benefit from a copyright and a design protection. This shows how it can affect the use of Creative Commons licences.

  10. Compatible solutes in lactic acid bacteria subjected to water stress.

    NARCIS (Netherlands)

    Kets, E.P.W.


    The goal of the research project described in this thesis was to investigate the protective effect of compatible solutes on tactic acid bacteria subjected to drying. Dried preparations of lactic acid bacteria are applied as starter cultures in feed and food industries. Dried starter cultures compare

  11. Leaders, Leadership and Democracy--Are They Compatible? (United States)

    Schostak, John


    This article is taken from a talk given by John Schostak at the Co-Operative Head Office, Manchester on 25 September 2015. Question addressed in this paper include: (1) To what extent is leadership needed for a democratic life?; (2) What form of democratic organisation, if any, is compatible with leadership?; and (3) Is democracy undermined by…

  12. Measures and electromagnetic compatibility; Mesures en compatibilite electromagnetique

    Energy Technology Data Exchange (ETDEWEB)

    Azoulay, A. [Centre Technique de TDF (France); Mardiguian, M.


    Since january 1996, the electrical compatibility is becoming more and more important with the european regulation (documented by the CE label) on electromagnetic disturbances. After the definitions and the classification of electromagnetic disturbances, the electrical appliances disturbances measure (radio frequencies and low frequencies, calibrating, appropriate instrumentation, operating conditions) and the immunity testing are presented. (A.L.B.)

  13. Unimodular sequence design under frequency hopping communication compatibility requirements (United States)

    Ge, Peng; Cui, Guolong; Kong, Lingjiang; Yang, Jianyu


    The integrated design for both radar and anonymous communication has drawn more attention recently since wireless communication system appeals to enhance security and reliability. Given the frequency hopping (FH) communication system, an effective way to realize integrated design is to meet the spectrum compatibility between these two systems. The paper deals with a unimodular sequence design technique which considers optimizing both the spectrum compatibility and peak sidelobes levels (PSL) of auto-correlation function (ACF). The spectrum compatibility requirement realizes anonymous communication for the FH system and provides this system lower probability of intercept (LPI) since the spectrum of the FH system is hidden in that of the radar system. The proposed algorithm, named generalized fitting template (GFT) technique, converts the sequence optimization design problem to a iterative fitting process. In this process, the power spectrum density (PSD) and PSL behaviors of the generated sequences fit both PSD and PSL templates progressively. Two templates are established based on the spectrum compatibility requirement and the expected PSL. As noted, in order to ensure the communication security and reliability, spectrum compatibility requirement is given a higher priority to achieve in the GFT algorithm. This algorithm realizes this point by adjusting the weight adaptively between these two terms during the iteration process. The simulation results are analyzed in terms of bit error rate (BER), PSD, PSL, and signal-interference rate (SIR) for both the radar and FH systems. The performance of GFT is compared with SCAN, CAN, FRE, CYC, and MAT algorithms in the above aspects, which shows its good effectiveness.

  14. Besser ohne Postmoderne – Kerstin Dietrichs exemplarische Re-Lektüre von vier ‚DDR-Autorinnen‘ Rather Without Postmodernism—Kerstin Dietrich’s Exemplary Re-Reading of Four Women Writers of the GDR

    Directory of Open Access Journals (Sweden)

    Corinna Heipcke


    Full Text Available Kerstin Dietrich untersucht Werke der vier ‚DDR-Autorinnen‘ Helga Königsdorf, Monika Maron, Anna Langhoff und Katja Lange-Müller. Die Verfasserin ordnet die von ihr ausgewählten Autorinnen zunächst zwei verschiedenen Schriftsteller(innengenerationen (in der DDR zu und ähnlich verfährt sie mit den untersuchten Werken: In den Texten Helga Königsdorfs und Monika Marons beobachtet sie Merkmale einer modernen Ästhetik, in den Texten von Karin Lange-Müller und Anna Langhoff Charakteristika postmoderner Ästhetik. Die Kategorie ‚postmoderne Ästhetik‘ bleibt in Dietrichs Darstellung allerdings unscharf und die exemplarische Neuerschließung von ‚DDR-Literatur‘ für die literaturästhetische Diskussion wäre Dietrich sicherlich auch ohne die Bemühung der Postmoderne-Diskussion gelungen.Dietrich investigates the works of four women authors of the GDR, Helga Königsdorf, Monika Maron, Anna Langhoff and Katja Lange-Müller. She identifies the four writers as belonging to two different generations of women GDR writers and treats their work accordingly. Whereas Dietrich focuses on the signs of a “modern aesthetics” in the works of the older writers, Maron and Königsdorf, she investigates the characteristics of “post-modern aesthetics” in the works of Lange-Müller and Langhoff. However, as Dietrich’s definition of a “post-modern aesthetic” remains rather unspecific and vague, her analysis might have been just as convincing if she had chosen not to include a discussion of the post-modern into her analysis.

  15. A review of magnetic resonance imaging compatible manipulators in surgery. (United States)

    Elhawary, H; Zivanovic, A; Davies, B; Lampérth, M


    Developments in magnetic resonance imaging (MRI), coupled with parallel progress in the field of computer-assisted surgery, mean that an ideal environment has been created for the development of MRI-compatible robotic systems and manipulators, capable of enhancing many types of surgical procedure. However, MRI does impose severe restrictions on mechatronic devices to be used in or around the scanners. In this article a review of the developments in the field of MRI-compatible surgical manipulators over the last decade is presented. The manipulators developed make use of different methods of actuation, but they can be reduced to four main groups: actuation transmitted through hydraulics, pneumatic actuators, ultrasonic motors based on the piezoceramic principle and remote manual actuation. Progress has been made concerning material selection, position sensing, and different actuation techniques, and design strategies have been implemented to overcome the multiple restrictions imposed by the MRI environment. Most systems lack the clinical validation needed to continue on to commercial products.


    Directory of Open Access Journals (Sweden)

    Codruta Dana Duda Daianu


    Full Text Available The team leader is the author of vision, mentor, guide, motivator, source of encouragement and supportive team. The leader helps team members to focus on the big picture of the project, to give the best of them, to follow the right path and stay united. Leader qualities must necessarily include its ability to work together, to be folded on the processes that describe functional and structural developments in embedded team. The issue of the leader development includes the necessity to concurrently form the skills of tem working. The working paper underlines that these two formative desiderate are compatible, correlative and complementary. So, in the study that we undertake we proposed to determine the degree of compatibility between the two demands of education, as follows: the training of leader capable to exercise also the specific activities of teamwork

  17. Poset pinball, GKM-compatible subspaces, and Hessenberg varieties

    CERN Document Server

    Harada, Megumi


    This paper has three main goals. First, we set up a general framework to address the problem of constructing module bases for the equivariant cohomology of certain subspaces of GKM spaces. To this end we introduce the notion of a GKM-compatible subspace of an ambient GKM space. We also discuss poset-upper-triangularity, a key combinatorial notion in both GKM theory and more generally in localization theory in equivariant cohomology. With a view toward other applications, we present parts of our setup in a general algebraic and combinatorial framework. Second, motivated by our central problem of building module bases, we introduce a combinatorial game which we dub poset pinball and illustrate with several examples. Finally, as first applications, we apply the perspective of GKM-compatible subspaces and poset pinball to construct explicit and computationally convenient module bases for the $S^1$-equivariant cohomology of all Peterson varieties of classical Lie type, and subregular Springer varieties of Lie type...

  18. Compatibility of hyaluronic acid hydrogel and skeletal muscle myoblasts

    Energy Technology Data Exchange (ETDEWEB)

    Wang Wei; Zhang Li; Sun Liang; Wang Chengyue [Jinzhou Central Hospital, Jinzhou 121000 (China); Fan Ming; Liu Shuhong, E-mail: [Institute of Basic Medical Sciences, Academy of Military Medical Science, Beijing 100850 (China)


    Compatibility of hyaluronic acid hydrogel (HAH) and skeletal muscle myoblasts has been investigated for the first time in the present paper. Skeletal muscle myoblasts were separated from skeletons of rats and incubated with a HAH-containing culture medium. Cell morphology, hydrophilicity and cell adhesion of the HAH scaffold were investigated using optical microscopy, scanning electron microscopy, Hoechest33258 fluorescent staining, the immunocytochemistry method and water adsorption rate measurement. It was found that at a proper concentration (around 0.5%) of hyaluronic acid, the hydrogel possessed good compatibility with skeletal muscle myoblasts. The hydrogel can create a three-dimensional structure for the growth of skeletal muscle myoblasts and benefit cell attachment to provide a novel scaffold material for the tissue engineering of skeletal muscle.

  19. Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy (United States)

    Zhao, Yiming; Fay, François; Hak, Sjoerd; Manuel Perez-Aguilar, Jose; Sanchez-Gaytan, Brenda L.; Goode, Brandon; Duivenvoorden, Raphaël; de Lange Davies, Catharina; Bjørkøy, Astrid; Weinstein, Harel; Fayad, Zahi A.; Pérez-Medina, Carlos; Mulder, Willem J. M.


    A major goal of cancer nanotherapy is to use nanoparticles as carriers for targeted delivery of anti-tumour agents. The drug-carrier association after intravenous administration is essential for efficient drug delivery to the tumour. However, a large number of currently available nanocarriers are self-assembled nanoparticles whose drug-loading stability is critically affected by the in vivo environment. Here we used in vivo FRET imaging to systematically investigate how drug-carrier compatibility affects drug release in a tumour mouse model. We found the drug's hydrophobicity and miscibility with the nanoparticles are two independent key parameters that determine its accumulation in the tumour. Next, we applied these findings to improve chemotherapeutic delivery by augmenting the parent drug's compatibility; as a result, we achieved better antitumour efficacy. Our results help elucidate nanomedicines' in vivo fate and provide guidelines for efficient drug delivery.

  20. Adapting deployed touch screen displays for NVG compatibility (United States)

    Gaudette, Claude


    As the battlefield becomes "digitized", all arms of the military are deploying COTS displays in the form of Portable Notebooks, Kneeboards, GPS and PDA's in ever greater numbers. Many of these COTS equipments and associated displays use full color LCD's and resistive touch panels as the operator-interface. These displays are a challenge to those who must modify the COTS equipment for NVG compatibility. Traditional NVG filter options have relatively poor color rendering and are too thick or rigid to interface with touch panels. In addition, many of these displays do not have sufficient dimming capabilities to allow covert night-time operations and do not have sufficient luminance for daytime operations. Polymeric materials recently developed by Wamco have been specifically designed for applications where traditional NVG filters have failed. These applications will be discussed and quantified in terms of NVG Compatibility, Color Rendering, Luminance Contrast and Daytime Readability, Touch Screen Sensitivity and Environmental Performance.

  1. Environmentally compatible next generation green energetic materials (GEMs). (United States)

    Talawar, M B; Sivabalan, R; Mukundan, T; Muthurajan, H; Sikder, A K; Gandhe, B R; Rao, A Subhananda


    This paper briefly reviews the literature work reported on the environmentally compatible green energetic materials (GEMs) for defence and space applications. Currently, great emphasis is laid in the field of high-energy materials (HEMs) to increase the environmental stewardship along with the deliverance of improved performance. This emphasis is especially strong in the areas of energetic materials, weapon development, processing, and disposal operations. Therefore, efforts are on to develop energetic materials systems under the broad concept of green energetic materials (GEMs) in different schools all over the globe. The GEMs program initiated globally by different schools addresses these challenges and establishes the framework for advances in energetic materials processing and production that promote compliance with environmental regulations. This review also briefs the principles of green chemistry pertaining to HEMs, followed by the work carried out globally on environmentally compatible green energetic materials and allied ingredients.

  2. PEG-grafted PVA Membrane and Its Blood Compatibility

    Institute of Scientific and Technical Information of China (English)

    JIN Gu; YAO Qi-zhi; DONG Li-quan; MA Feng


    Preparation and blood compatibility of different shape polyvinyl alcohol(PVA)membrane were investigated.Firstly,the tabular and tubular[polytetrafluoroethylene(PTFE)capillary as supporter]PVA membranes were prepared; then,methoxy polyethylene glycol(mPEG)was grafted onto the surface of the PVA membranes.The effects of the shape,structure and properties of the membrane surface on blood compatibility were studied in detail.The experiment results show that mPEG modified PVA membranes,especially mPEG modified tubular membrane,could availably repel the adhesion of the platelets.In addition,the anticoagulant mechanism of mPEG with a steric repulsion effectiveness was confirmed further via different grafting methods.

  3. Compatible plant-aphid interactions: how aphids manipulate plant responses. (United States)

    Giordanengo, Philippe; Brunissen, Laurence; Rusterucci, Christine; Vincent, Charles; van Bel, Aart; Dinant, Sylvie; Girousse, Christine; Faucher, Mireille; Bonnemain, Jean-Louis


    To access phloem sap, aphids have developed a furtive strategy, their stylets progressing towards sieve tubes mainly through the apoplasmic compartment. Aphid feeding requires that they overcome a number of plant responses, ranging from sieve tube occlusion and activation of phytohormone-signalling pathways to expression of anti-insect molecules. In addition to bypassing plant defences, aphids have been shown to affect plant primary metabolism, which could be a strategy to improve phloem sap composition in nutrients required for their growth. During compatible interactions, leading to successful feeding and reproduction, aphids cause alterations in their host plant, including morphological changes, modified resource allocation and various local as well as systemic symptoms. Repeated salivary secretions injected from the first probe in the epidermal tissue up to ingestion of sieve-tube sap may play a crucial role in the compatibility between the aphid and the plant.

  4. Compatibility of structural materials with liquid bismuth, lead, and mercury

    Energy Technology Data Exchange (ETDEWEB)

    Weeks, J.R. [Brookhaven National Lab., Upton, NY (United States)


    During the 1950s and 1960s, a substantial program existed at Brookhaven National Laboratory as part of the Liquid Metal Fuel reactor program on the compatibility of bismuth, lead, and their alloys with structural materials. Subsequently, compatibility investigations of mercury with structural materials were performed in support of development of Rankine cycle mercury turbines for nuclear applications. The present talk will review present understanding of the corrosion/mass-transfer reactions of structural materials with these liquid metal coolants. Topics to be discussed include the basic solubility relationships of iron, chromium, nickel, and refractory metals in these liquid metals, the results of inhibition studies, the role of oxygen on the corrosion processes, and specialized topics such as cavitation-corrosion and liquid metal embrittlement. Emphasis will be placed on utilizing the understanding gained in this earlier work on the development of heavy liquid metal targets in spallation neutron sources.

  5. On Rate-Compatible Punctured Turbo Codes Design

    Directory of Open Access Journals (Sweden)

    Montorsi Guido


    Full Text Available We propose and compare some design criteria for the search of good systematic rate-compatible punctured turbo code (RCPTC families. The considerations presented by S. Benedetto et al. (1998 to find the "best" component encoders for turbo code construction are extended to find good rate-compatible puncturing patterns for a given interleaver length . This approach is shown to lead to codes that improve over previous ones, both in the maximum-likelihood sense (using transfer function bounds and in the iterative decoding sense (through simulation results. To find simulation and analytical results, the coded bits are transmitted over an additive white Gaussian noise (AWGN channel using an antipodal binary modulation. The two main applications of this technique are its use in hybrid incremental ARQ/FEC schemes and its use to achieve unequal error protection of an information sequence.

  6. Preparation of anionic polyurethane nanoparticles and blood compatible behaviors. (United States)

    Zhu, Qinshu; Wang, Yan; Zhou, Min; Mao, Chun; Huang, Xiaohua; Bao, Jianchun; Shen, Jian


    The anionic polyurethane nanoparticles (APU-NPs) were obtained by an emulsion polymerization method. It was found that the average size of the prepared APU-NPs is about 84 nm, and the APU-NPs have zeta-potential of -38.9 mV. The bulk characterization of synthesized APU-NPs was investigated by FTIR. The blood compatibility of APU-NPs was characterized by in vitro for coagulation tests, complement activation, platelet activation, cytotoxicity experiments, and hemolysis assay. The results showed that the APU-NPs synthesized in this paper are blood compatible with low level of cell cytotoxicity, and the results were significant for their potential use in vivo.

  7. S3c, prototipos de vivienda construidos por componentes compatibles

    Directory of Open Access Journals (Sweden)

    Reyes González, J. Miguel


    Full Text Available What is the construction by compatible components about? Which are its plants? Which results and answers does it add? Which consequences and implications does it lead to? To these other questions related with the subject, this work tries to give answer, not by definitions and generalities which would fail in the field of a theoretical disquisition but by a review of determined prototypes and projects of dwellings built during the last ten years, which will lead us, on base of its descriptions, to expose out in particular: — Methodological conditions: "open orders". — Technological conditions: "compatible compounds". — Trade conditions: "open prefabrication". — Transformation conditions: actualization?¿Qué es la construcción por componentes compatibles? ¿En qué consiste? ¿Cuáles son sus planteamientos? ¿Qué resultados y respuestas aporta? ¿Qué consecuencias e implicaciones conlleva? A estas y otras cuestiones relacionadas con el tema tratan de dar respuesta estas páginas, pero recurriendo para ello no a definiciones y generalidades que podrían sucumbir en el mundo de las disquisiciones teóricas, sino haciendo referencia a prototipos y proyectos concretos de vivienda realizados en la última década que servirán para, a partir de su descripción, exponer las particulares condiciones que de los mismos se desprenden: — Metodológicas: ''órdenes abiertos". — Tecnológicas: ''componentes compatibles". — De mercado: "prefabricación abierta". — Transformación: ¿actualización?

  8. Object affordance and spatial-compatibility effects in Parkinson's disease. (United States)

    Galpin, Adam; Tipper, Steven P; Dick, Jeremy P R; Poliakoff, Ellen


    Movement in Parkinson's disease (PD) is strongly influenced by sensory stimuli. Here, we investigated two features of visual stimuli known to affect response times in healthy individuals; the spatial location of an object (the spatial effect) and its action-relevance (the 'affordance' effect). Poliakoff et al. (2007) found that while PD patients show normal spatial effects, they do not show an additional affordance effect. Here we investigated whether these effects are driven by facilitation or inhibition, and whether the affordance effect emerges over a longer time-course in PD. Participants (24 PD and 24 controls) viewed either a lateralised door handle (affordance condition), a lateralised abstract stimulus (spatial condition), or a centrally presented baseline stimulus (baseline condition), and responded to a colour change in the stimulus occurring after 0 msec, 500 msec or 1000 msec. The colour change indicated whether to respond with the left or right hand, which were either spatially compatible or incompatible with the lateralised stimulus orientation in the affordance and spatial conditions. The baseline condition allowed us to assess whether compatibility effects were driven by facilitation of the compatible response or inhibition of the incompatible response. The results indicate that stimulus orientation elicited faster responses from the nearest hand. For controls, the affordance effect was stronger and driven by facilitation, whilst the spatial condition was driven by inhibition. In contrast, the affordance and spatial-compatibility effects did not differ between conditions in the PD group and both were driven by facilitation. This suggests that the PD group responded as if all stimuli were action-relevant, and may have implications for understanding the cueing of movement in PD.

  9. Miniaturised Spotter-Compatible Multicapillary Stamping Tool for Microarray Printing


    Drobyshev, Alexei L.; Verkhodanov, Nikolai N; Zasedatelev, Alexander S.


    Novel microstamping tool for microarray printing is proposed. The tool is capable to spot up to 127 droplets of different solutions in single touch. It is easily compatible with commercially available microarray spotters. The tool is based on multichannel funnel with polypropylene capillaries inserted into its channels. Superior flexibility is achieved by ability to replace any printing capillary of the tool. As a practical implementation, hydrogel-based microarrays were stamped and successfu...

  10. Miniaturised Spotter-Compatible Multicapillary Stamping Tool for Microarray Printing

    CERN Document Server

    Drobyshev, A L; Zasedatelev, A S; Drobyshev, Alexei L; Verkhodanov, Nikolai N; Zasedatelev, Alexander S


    Novel microstamping tool for microarray printing is proposed. The tool is capable to spot up to 127 droplets of different solutions in single touch. It is easily compatible with commercially available microarray spotters. The tool is based on multichannel funnel with polypropylene capillaries inserted into its channels. Superior flexibility is achieved by ability to replace any printing capillary of the tool. As a practical implementation, hydrogel-based microarrays were stamped and successfully applied to identify the Mycobacterium tuberculosis drug resistance.

  11. A compatibility study of FEFO with various containment materials

    Energy Technology Data Exchange (ETDEWEB)

    Shepodd, T.J.; Goods, S.H. [Sandia National Labs., Livermore, CA (United States); Foster, P. [Mason and Hanger-Silas Mason Co., Inc., Amarillo, TX (United States)


    Compatibility between FEFO (bis-(2-fluoro-2,2-dinitroethyl) formal) and a number of organic and metallic materials was evaluated at 22 and 74 C for up to 8 months. The metals included common structural alloys and elemental metals that the extrudable explosive might contact in its service life. The organic materials included flexible materials for use as collapsible extrusion membranes or permeation barriers, rigid engineering resins (matrices for composite vessels), and polymer viscosity modifiers.

  12. Preparation and Blood Compatibility of Oxidized-chitosan Films

    Institute of Scientific and Technical Information of China (English)

    Yue Dong YANG; Jiu Gao YU; Yong Guo ZHOU; Pei Guo LI


    Chitosan membrane was modified by the selective oxidization of chitosan molecules on its surface with NO2 gas. FTIR spectra indicated there were plenty of-COOH and -COO- groups on the modified membrane surface. The SEM study showed the modified membrane surface was rough rather than smooth as chitosan membrane. All antithrombosis test, hemolysis test and blood cell morphology observation with SEM revealed that modified chitosan membranes have superior blood compatibility to chitosan.

  13. Compatibility analysis of 3D printer resin for biological applications

    KAUST Repository

    Sivashankar, Shilpa


    The salient features of microfluidics such as reduced cost, handling small sample and reagent volumes and less time required to fabricate the devices has inspired the present work. The incompatibility of three-dimensional printer resins in their native form and the method to improve their compatibility to many biological processes via surface modification are reported. The compatibility of the material to build microfluidic devices was evaluated in three different ways: (i) determining if the ultraviolet (UV) cured resin inhibits the polymerase chain reaction (PCR), i.e. testing devices for PCR compatibility; (ii) observing agglutination complex formed on the surface of the UV cured resin when anti-C-reactive protein (CRP) antibodies and CRP proteins were allowed to agglutinate; and (iii) by culturing human embryonic kidney cell line cells and testing for its attachment and viability. It is shown that only a few among four in its native form could be used for fabrication of microchannels and that had the least effect on biological molecules that could be used for PCR and protein interactions and cells, whereas the others were used after treating the surface. Importance in building lab-on-chip/micrototal analysis systems and organ-on-chip devices is found.

  14. Assessment of DUPIC fuel compatibility with CANDU-6

    Energy Technology Data Exchange (ETDEWEB)

    Choi, H. B.; Roh, G. H.; Jeong, C. J.; Rhee, B. W.; Choi, J. W. [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)


    The compatibility of DUPIC fuel with the existing CANDU reactor was assessed. The technical issues of DUPIC fuel compatibility were chosen based on the CANDU physics design requirements and inherent characteristics of DUPIC fuel. The compatibility was assessed for the reference DUPIC fuel composition which was determined to reduce the composition heterogeneity and improve the spent PWR fuel utilization. Preliminary studies on a CANDU core loaded with DUPIC fuel have shown that the nominal power distribution is flatter than that of a natural uranium core when a 2-bundle shift refueling scheme is used, which reduces the reactivity worths of devices in the core and, therefore, the performance of reactivity devices was assessed. The safety of the core was assessed by a LOCA simulation and it was found that the power pulse upon LOCA can be maintained below that in the natural uranium core when a poison material is used in the DUPIC fuel. For the feasibility of handling DUPIC fuel in the plant, it will be necessary to introduce new equipment to load the DUPIC fuel in the refueling magazine. The radiation effect of DUPIC fuel on both the reactor hardware and the environment will require a quantitative analysis later. (author).

  15. Compatibility of novel blends from polyolefin and coal

    Energy Technology Data Exchange (ETDEWEB)

    Yang, F.; Zhou, A. [Xi' an Jiaotong University, Xi' an (China). School of Material Science and Engineering


    Melt blends of low-density polyethylene (LDPE), ethylene vinyl acetate (EVA) and coal with various compositions were prepared through reactive extrusion. The rheological behaviour was studied with respect to the effect of blend ratio, shear rate using a rheometer to gain an understanding of processing parameters controlling industrial application. Compatibility was also evaluated by differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The results revealed that LDPE/EVA/coal is a partly compatible system showing pseudo-plastic behaviour, increase in viscosity with increased coal content appears evident only at low shear rate, viscosity tends to keep consistent approximately but varies with coal content at higher shear rate. Viscosity and compatibility of blends are attributed to changes in LDPE crystalline structure and entanglement, together with interaction between macromolecular aliphatic chains in coal and amorphous phase in LDPE and EVA at the boundaries of phases, which appears during the re-arrangement process of the crystalline structure. 8 refs., 5 figs., 3 tabs.

  16. Eco-Anthropic Compatibility - a Multidisciplinary Model in Urban Ecology

    Directory of Open Access Journals (Sweden)



    Full Text Available In this paper I propose a multidisciplinary model of urban development which goes beyond the notion of ecological sustainability, by building on the concept of eco-anthropic compatibility. First of all I will sketch the historical development of human aggregations and I will underline the difference between ancient and modern aggregations. On the basis of this analysis, I will take into consideration the notion of sustainability and its possible application to present conurbations. I will underline several limits of the notion of sustainable development and I will propose a multidisciplinary model grounded on a broader and new notion: the eco-anthropic compatibility. Using this notion, which includes the idea of sustainability, it is possible to handle, within the model, the human factors and human living conditions inside an urban aggregation. Finally, I will state that the actual urban model is decaying and therefore, sooner or later, we will have to face the end of urban civilization; for this reason we can start imagining new future ways for human aggregations on the planet based on the notion of eco-anthropic compatibility.

  17. Compatibility studies of metallic materials with lithium-based oxides (United States)

    Hofmann, P.; Dienst, W.


    The compatibility of Li 2O, Li 4SiO 4 and Li 2SiO 3 with the cladding materials AISI 316, 1.4914, Hastelloy X and Inconel 625 was investigated at 800-1000°C for annealing times up to 1000 h. A controlled oxygen reactivity was established by adding 1 mol% NiO per mole Li 2O to the Li-based oxides. In addition, some compatibility tests were performed at 600-900°C on Be, which is of interest as a neutron multiplier material, with Li 2SiO 3 as well as AISI 316. Li 2O accounted for the strongest cladding attack, followed by Li 4SiO 4 and Li 2SiO 3. In the absence of NiO, Li 2SiO 3 caused no chemical interactions at all. With respect to the cladding materials, there was no considerable difference in the reaction rates of AISI 316, Hastelloy X and Inconel 625. However, the steel 1.4914 was clearly more heavily attacked at and above 800°C. The compatibility of Be with Li 2SiO 3 or AISI 316 seems to be tolerable up to about 650°C. At higher temperatures a liquid Li suicide phase is formed which results in strong local attack and penetration into Li 2SiO 3.

  18. A Zeroth Law Compatible Model to Kerr Black Hole Thermodynamics

    Directory of Open Access Journals (Sweden)

    Viktor G. Czinner


    Full Text Available We consider the thermodynamic and stability problem of Kerr black holes arising from the nonextensive/nonadditive nature of the Bekenstein–Hawking entropy formula. Nonadditive thermodynamics is often criticized by asserting that the zeroth law cannot be compatible with nonadditive composition rules, so in this work we follow the so-called formal logarithm method to derive an additive entropy function for Kerr black holes also satisfying the zeroth law’s requirement. Starting from the most general, equilibrium compatible, nonadditive entropy composition rule of Abe, we consider the simplest non-parametric approach that is generated by the explicit nonadditive form of the Bekenstein–Hawking formula. This analysis extends our previous results on the Schwarzschild case, and shows that the zeroth law-compatible temperature function in the model is independent of the mass–energy parameter of the black hole. By applying the Poincaré turning point method, we also study the thermodynamic stability problem in the system.

  19. Blood compatibility of polyurethane surface grafted copolymerization with sulfobetaine monomer. (United States)

    Jiang, Yuan; Rongbing, Bian; Ling, Tong; Jian, Shen; Sicong, Lin


    Surface modification is an effective way to improve the hemocompatibility and remain bulk properties of biomaterials. Recently, polymer tailed with zwitterions was found having good blood compatibility. In this study, the grafting copolymerization of sulfobetaine onto polyurethane surface was obtained through two steps. In the first step, polyurethane film coupled with vinyl groups was obtained through the reaction between the carboxyl group of acrylic acid (AA) and the NH-urethane group of polyurethane by dicyclohexylcarbodiimide (DCC). In the second step, sulfobetaine was grafted copolymerization on the surface using AIBN as an initiator. The reaction process was monitored with ATR-IR spectra and X-ray photoelectron spectroscopy (XPS) spectra. The wettability of films was investigated by water contact angle measurement. The blood compatibility of the grafted films was evaluated by platelet adhesion in platelet rich plasma (PRP) and protein absorption in bovine fibrinogen (BFG). Low platelet adhesion was observed on the grafted films incubated in PRP for 1 and 3 h, respectively. The protein absorption was reduced on the grafted films after incubated in bovine fibrinogen for 2 h. All of these results revealed that the improved blood compatibility was obtained by grafting copolymerization with zwitterionic monomer of sulfobetaine onto polyurethane film. In addition, introducing vinyl groups onto surface through DCC and AA is a novel method to functionalize polyurethane for further modification.

  20. Fitness consequences of parental compatibility in the frog Crinia georgiana. (United States)

    Dziminski, Martin A; Roberts, J Dale; Simmons, Leigh W


    Theory suggests that multiple mating by females can evolve as a mechanism for acquiring compatible genes that promote offspring fitness. Genetic compatibility models predict that differences in fitness among offspring arise from interactions between male and female haplotypes. Using a cross-classified breeding design and in vitro fertilization, we raised families of maternal and paternal half-siblings of the frog Crinia georgiana, a species with a polyandrous breeding system and external fertilization. After controlling for variation in maternal provisioning, we found significant effects of interacting parental haplotypes on fertilization success, and nonadditive genetic effects on measures of offspring fitness such as embryo survival, and survival to, size at, and time to metamorphosis. Additive genetic variation due to males and females was negligible, and not statistically significant for any of the fitness traits measured. Combinations of parental haplotypes that resulted in high rates of fertilization produced offspring with higher embryo survival and rapid juvenile development. We suggest that a gamete recognition mechanism for selective fertilization by compatible sperm may promote offspring fitness in this system.

  1. 76 FR 39095 - Compatibility of Underground Storage Tank Systems With Biofuel Blends (United States)


    ... aggressive toward certain materials than independent fuel constituents, with maximum polymer swelling... Engineer (P.E.) to make a compatibility determination. Although using P.E.s to determine compatibility...

  2. 76 FR 46798 - Compatibility of Underground Storage Tank Systems With Biofuel Blends; Correction (United States)


    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Compatibility of Underground Storage Tank Systems With Biofuel Blends; Correction AGENCY... compliance with the Federal compatibility requirement for UST systems storing gasoline greater than...

  3. Compatibility of the Radio Frequency Mass Gauge with Composite Tanks (United States)

    Zimmerli, Greg; Mueller, Carl


    The radio frequency mass gauge (RFMG) is a low-gravity propellant quantity gauge being developed at NASA for possible use in long-duration space missions utilizing cryogenic propellants. As part of the RFMG technology development process, we evaluated the compatibility of the RFMG with a graphite-epoxy composite material used to construct propellant tanks. The key material property that can affect compatibility with the RFMG is the electrical conductivity. Using samples of 8552IM7 graphite-epoxy composite, we characterized the resistivity and reflectivity over a range of frequencies. An RF impedance analyzer was used to characterize the out-of-plane electrical properties (along the sample thickness) in the frequency range 10 to 1800 MHZ. The resistivity value at 500 MHz was 4.8 ohm-cm. Microwave waveguide measurements of samples in the range 1.7 2.6 GHz, performed by inserting the samples into a WR-430 waveguide, showed reflectivity values above 98. Together, these results suggested that a tank constructed from graphite-epoxy composite would produce good quality electromagnetic tank modes, which is needed for the RFMG. This was verified by room-temperature measurements of the electromagnetic modes of a 2.4 m diameter tank constructed by Boeing from similar graphite-epoxy composite material. The quality factor Q of the tank electromagnetic modes, measured via RF reflection measurements from an antenna mounted in the tank, was typically in the range 400 Q 3000. The good quality modes observed in the tank indicate that the RFMG is compatible with graphite-epoxy tanks, and thus the RFMG could be used as a low-gravity propellant quantity gauge in such tanks filled with cryogenic propellants.

  4. Characterizing and Optimizing the Performance of the MAESTRO 49-Core Processor (United States)


    DDR memory controllers which are now compatible with both DDR1 and DDR2 memory. [17] In addition to creating the MAESTRO board, OPERA also produced the...GFLOPS (Peak) — single or double precision 25 XAUI Interfaces (4) (errata: half duplex) 10 GBPS (each — half duplex) DDR2 rate (4) 266 MHZ (each

  5. 47 CFR 64.608 - Provision of hearing aid compatible telephones by exchange carriers. (United States)


    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Provision of hearing aid compatible telephones... Provision of hearing aid compatible telephones by exchange carriers. In the absence of alternative suppliers in an exchange area, an exchange carrier must provide a hearing aid compatible telephone, as...

  6. 47 CFR 68.415 - Hearing aid-compatibility and volume control informal complaints. (United States)


    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Hearing aid-compatibility and volume control... Procedures § 68.415 Hearing aid-compatibility and volume control informal complaints. Persons with complaints... complaints regarding rules in this part pertaining to hearing aid compatibility and volume control, may...

  7. 46 CFR 150.160 - Carrying a cargo as an exception to the compatibility chart. (United States)


    ... 46 Shipping 5 2010-10-01 2010-10-01 false Carrying a cargo as an exception to the compatibility... BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.160 Carrying a cargo as an exception to the compatibility chart. The Operator of a vessel having on board a cargo carried as an exception under §...

  8. 49 CFR 350.333 - What are the guidelines for the compatibility review? (United States)


    ... 49 Transportation 5 2010-10-01 2010-10-01 false What are the guidelines for the compatibility... the compatibility review? (a) The State law or regulation must apply to all segments of the motor... regulations reviewed for the CDL compliance report are excluded from the compatibility review. (c)...

  9. Central Cross-Talk in Task Switching : Evidence from Manipulating Input-Output Modality Compatibility (United States)

    Stephan, Denise Nadine; Koch, Iring


    Two experiments examined the role of compatibility of input and output (I-O) modality mappings in task switching. We define I-O modality compatibility in terms of similarity of stimulus modality and modality of response-related sensory consequences. Experiment 1 included switching between 2 compatible tasks (auditory-vocal vs. visual-manual) and…

  10. 47 CFR 68.224 - Notice of non-hearing aid compatibility. (United States)


    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Notice of non-hearing aid compatibility. 68.224 Section 68.224 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES... § 68.224 Notice of non-hearing aid compatibility. Every non-hearing aid compatible telephone...

  11. High Pressure Hydrogen Materials Compatibility of Piezoelectric Films

    Energy Technology Data Exchange (ETDEWEB)

    Alvine, Kyle J.; Shutthanandan, V.; Bennett, Wendy D.; Bonham, Charles C.; Skorski, Daniel C.; Pitman, Stan G.; Dahl, Michael E.; Henager, Charles H.


    Abstract: Hydrogen is being considered as a next-generation clean burning fuel. However, hydrogen has well known materials issues, including blistering and embrittlement in metals. Piezoelectric materials are used as actuators in hydrogen fuel technology. We present studies of materials compatibility of piezoelectric films in a high pressure hydrogen environment. Absorption of high pressure hydrogen was studied with Elastic Recoil Detection Analysis (ERDA) and Rutherford Back Scattering (RBS) in lead zirconate titanate (PZT) and barium titanate (BTO) thin films. Hydrogen surface degradation in the form of blistering and Pb mixing was also observed.

  12. A Safety-Critical Java Technology Compatibility Kit

    DEFF Research Database (Denmark)

    Søndergaard, Hans; Korsholm, Stephan Erbs; Ravn, Anders P.


    In order to claim conformance with a given Java Specification Request (JSR), a Java implementation has to pass all tests in an associated Technology Compatibility Kit (TCK). This paper presents development of test cases and tools for the draft Safety-Critical Java (SCJ) specification. In previous...... work we have shown how the Java Modeling Language (JML) is applied to specify conformance constraints for SCJ, and how JML-related tools may assist in generating and executing tests. Here we extend this work with a layout for concrete test cases including checking of results in a simplified version...

  13. Technical Basis for Electromagnetic Compatibility Regulatory Guidance Update

    Energy Technology Data Exchange (ETDEWEB)

    Ewing, Paul D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Korsah, Kofi [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Harrison, Thomas J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wood, Richard Thomas [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Mays, Gary T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)


    The objective of this report is to serve as the technical basis document for the next, planned revision of this RG that highlights and provides the rationale for the recommended changes. The structure of this document follows and summarizes the several assessment activities undertaken during the course of this project to evaluate new and updated electromagnetic compatibility (EMC) standards, testing methods and limits, and relevant technology developments being incorporated into plant activities that may have EMI/RFI implications, as well as other specific issues, including impacts of electrostatic discharge (ESD) on safety equipment and impacts on increased usage of wireless devices in nuclear power plants.

  14. A safety-critical java technology compatibility kit

    DEFF Research Database (Denmark)

    Søndergaard, Hans; Korsholm, Stephan E.; Ravn, Anders Peter


    In order to claim conformance with a given Java Specification Request (JSR), a Java implementation has to pass all tests in an associated Technology Compatibility Kit (TCK). This paper presents development of test cases and tools for the draft Safety-Critical Java (SCJ) specification. In previous...... work we have shown how the Java Modeling Language (JML) is applied to specify conformance constraints for SCJ, and how JML-related tools may assist in generating and executing tests. Here we extend this work with a layout for concrete test cases including checking of results in a simplified version...

  15. Electromagnetic Compatibility Analysis Group VA-H3 (United States)

    Armanda, Carlos A.


    During the eight weeks working at NASA, I was fortunate enough to work with the Expendable Launch Vehicle's (ELV) Electromagnetic Compatibility (EMC) Team, who is responsible for the evaluation and analysis of any EMI risk an ELV mission might face. This group of people concern themselves with practically any form of electromagnetic interference that may risk the safety of a rocket, a mission, or even people. Taking this into consideration, the group investigates natural forms of interference, such as lightning, to manmade interferences, such as antennas.

  16. Satellite antenna layout and optimization in electromagnetic compatibility design (United States)

    Zhang, Jinshuo; Xie, Shuguo; Liu, Yan


    This paper firstly analyzes the main factors that impact the layout of satellite antenna. The uniform geometrical theory of diffraction (UTD) is used to establish mathematical model for calculating the coupling of satellite antenna, and set up the objective function of the placement optimization. The genetic algorithm incorporating high-frequency simulation to minimize antenna coupling by optimally positioning satellite antenna is described in detail. The results of antenna placement on a realistic satellite show that this method is effective in the optimal design of satellite antenna layout for the purpose of electromagnetic compatibility.

  17. Affine transformations from aerial photos to computer compatible tapes (United States)

    Peet, F. G.; Mack, A. R.; Crosson, L. S.


    During the development of a project to estimate wheat production, it became necessary to pull data, corresponding to particular fields in a test site, off an ERTS computer compatible tape. Aerial photographs and topographic maps were on hand for the test site. A method was devised, using an affine transformation, to relate the aerial photographs or topographic maps to the tapes. One can thereby access data on the tape corresponding to regions covered by only a few pixels. The theory can be used for the registration of two tapes for the same area and for the geometric correction of images.

  18. Chemical compatibility of structural materials in alkali metals

    Energy Technology Data Exchange (ETDEWEB)

    Natesan, K.; Rink, D.L.; Haglund, R. [Argonne National Lab., Chicago, IL (United States)] [and others


    The objectives of this task are to (a) evaluate the chemical compatibility of structural alloys such as V-5 wt.%Cr-5 wt.%Ti alloy and Type 316 stainless steel for application in liquid alkali metals such as lithium and sodium-78 wt.% potassium (NaK) at temperatures in the range that are of interest for International Thermonuclear Experimental Reactor (ITER); (b) evaluate the transfer of nonmetallic elements such as oxygen, nitrogen, carbon, and hydrogen between structural materials and liquid metals; and (c) evaluate the effects of such transfers on the mechanical and microstructural characteristics of the materials for long-term service in liquid-metal-environments.

  19. Advanced Machinery Liquid Metal Wetting, Cleaning and Materials Compatibility Study (United States)


    barium doped NaK 7 8 at temperatures to lOO 0 C for 250 and 500 hours. Doping of the liquid metal created no compatibility... metal - solid metal interface specific contact resistance (ck). Two liquid metal compositions were used, NaK 7 8 and barium doped NaK 7 8 . The...three with NaK - barium as the liquid metal and eight with NaK . They were ranked in ascending value of mean interface specific contact

  20. Tri-Axial MRI Compatible Fiber-optic Force Sensor (United States)

    Tan, U-Xuan; Yang, Bo; Gullapalli, Rao; Desai, Jaydev P.


    Magnetic resonance imaging (MRI) has been gaining popularity over standard imaging modalities like ultrasound and CT because of its ability to provide excellent soft-tissue contrast. However, due to the working principle of MRI, a number of conventional force sensors are not compatible. One popular solution is to develop a fiber-optic force sensor. However, the measurements along the principal axes of a number of these force sensors are highly cross-coupled. One of the objectives of this paper is to minimize this coupling effect. In addition, this paper describes the design of elastic frame structures that are obtained systematically using topology optimization techniques for maximizing sensor resolution and sensor bandwidth. Through the topology optimization approach, we ensure that the frames are linked from the input to output. The elastic frame structures are then fabricated using polymers materials, such as ABS and Delrin®, as they are ideal materials for use in MRI environment. However, the hysteresis effect seen in the displacement-load graph of plastic materials is known to affect the accuracy. Hence, this paper also proposes modeling and addressing this hysteretic effect using Prandtl-Ishlinskii play operators. Finally, experiments are conducted to evaluate the sensor’s performance, as well as its compatibility in MRI under continuous imaging. PMID:21666783

  1. Development of hazard-compatible building fragility and vulnerability models (United States)

    Karaca, E.; Luco, N.


    We present a methodology for transforming the structural and non-structural fragility functions in HAZUS into a format that is compatible with conventional seismic hazard analysis information. The methodology makes use of the building capacity (or pushover) curves and related building parameters provided in HAZUS. Instead of the capacity spectrum method applied in HAZUS, building response is estimated by inelastic response history analysis of corresponding single-degree-of-freedom systems under a large number of earthquake records. Statistics of the building response are used with the damage state definitions from HAZUS to derive fragility models conditioned on spectral acceleration values. Using the developed fragility models for structural and nonstructural building components, with corresponding damage state loss ratios from HAZUS, we also derive building vulnerability models relating spectral acceleration to repair costs. Whereas in HAZUS the structural and nonstructural damage states are treated as if they are independent, our vulnerability models are derived assuming "complete" nonstructural damage whenever the structural damage state is complete. We show the effects of considering this dependence on the final vulnerability models. The use of spectral acceleration (at selected vibration periods) as the ground motion intensity parameter, coupled with the careful treatment of uncertainty, makes the new fragility and vulnerability models compatible with conventional seismic hazard curves and hence useful for extensions to probabilistic damage and loss assessment.

  2. Quality control for quantitative PCR based on amplification compatibility test. (United States)

    Tichopad, Ales; Bar, Tzachi; Pecen, Ladislav; Kitchen, Robert R; Kubista, Mikael; Pfaffl, Michael W


    Quantitative qPCR is a routinely used method for the accurate quantification of nucleic acids. Yet it may generate erroneous results if the amplification process is obscured by inhibition or generation of aberrant side-products such as primer dimers. Several methods have been established to control for pre-processing performance that rely on the introduction of a co-amplified reference sequence, however there is currently no method to allow for reliable control of the amplification process without directly modifying the sample mix. Herein we present a statistical approach based on multivariate analysis of the amplification response data generated in real-time. The amplification trajectory in its most resolved and dynamic phase is fitted with a suitable model. Two parameters of this model, related to amplification efficiency, are then used for calculation of the Z-score statistics. Each studied sample is compared to a predefined reference set of reactions, typically calibration reactions. A probabilistic decision for each individual Z-score is then used to identify the majority of inhibited reactions in our experiments. We compare this approach to univariate methods using only the sample specific amplification efficiency as reporter of the compatibility. We demonstrate improved identification performance using the multivariate approach compared to the univariate approach. Finally we stress that the performance of the amplification compatibility test as a quality control procedure depends on the quality of the reference set.

  3. Compatibility of hydroxypropyl-{beta}-cyclodextrin with algal toxicity bioassays

    Energy Technology Data Exchange (ETDEWEB)

    Fai, Patricia Bi; Grant, Alastair [School of Environmental Sciences, University of East Anglia, Norwich NR4 7TJ (United Kingdom); Reid, Brian J. [School of Environmental Sciences, University of East Anglia, Norwich NR4 7TJ (United Kingdom)], E-mail:


    Numerous reports have indicated that hydrophobic organic compound bioaccessibility in sediment and soil can be determined by extraction using aqueous hydroxypropyl-{beta}-cyclodextrin (HPCD) solutions. This study establishes the compatibility of HPCD with Selenastrum capricornutum and assesses whether its presence influences the toxicity of reference toxicants. Algal growth inhibition (72 h) showed no significant (P > 0.05) difference at HPCD concentrations up to and including 20 mM. HPCD presence did not influence the toxicity of the inorganic reference toxicant (ZnSO{sub 4}), with IC50 values of 0.82 {mu}M and 0.85 {mu}M, in the presence and absence of HPCD (20 mM), respectively. However, HPCD presence (20 mM) reduced the toxicity of 2,4-dichlorophenol and the herbicides diuron and isoproturon. These reductions were attributed to inclusion complex formation between the toxicants and the HPCD cavity. Liberation of complexed toxicants, by sample manipulation prior to toxicity assessment, is proposed to provide a sensitive, high throughput, bioassay that reflects compound bioaccessibility. - Compatibility of the biomimetic HPCD extraction method with algal cell growth inhibition bioassays to assess toxicity of reference toxicants and environmental relevant herbicides.

  4. Compatibility Studies on Elastomers and Polymers with Ethanol Blended Gasoline

    Directory of Open Access Journals (Sweden)

    J. S. Dhaliwal


    Full Text Available This paper reports the compatibility studies of 10% ethanol blended gasoline (E10 with four types of elastomer materials, namely, Neoprene rubber, Nitrile rubber, hydrogenated Nitrile butadiene rubber (HNBR, and Polyvinyl chloride/Nitrile butadiene rubber blend (PVC/NBR, and two types of plastic materials, namely, Nylon-66 and Polyoxymethylene (Delrin. These materials have applications in automotives as engine seals, gaskets, fuel system seals and hoses, and so forth. Two types of the ethanol blended gasoline mixtures were used: (a gasoline containing 5% ethanol (E5, which is commercial form of gasoline available in India, and (b gasoline containing 10% ethanol (E10. The above materials were immersed in E5 and E10 for 500 hrs at 55°C. A set of eight different properties in E5 and E10 (visual inspection, weight change, volume change, tensile strength, percent elongation, flexural strength, impact strength, and hardness were measured after completion of 500 hrs and compared with reference specimens (specimens at 55°C without fuel and specimens at ambient conditions. Variation observed in different materials with respect to the above eight properties has been used to draw inference about the compatibility of these elastomeric/polymer materials with E10 fuel vis-à-vis E5 fuels. The data presented in this study is comparative in nature between the results of E10 and E5.

  5. Efficient FPT Algorithms for (Strict) Compatibility of Unrooted Phylogenetic Trees. (United States)

    Baste, Julien; Paul, Christophe; Sau, Ignasi; Scornavacca, Celine


    In phylogenetics, a central problem is to infer the evolutionary relationships between a set of species X; these relationships are often depicted via a phylogenetic tree-a tree having its leaves labeled bijectively by elements of X and without degree-2 nodes-called the "species tree." One common approach for reconstructing a species tree consists in first constructing several phylogenetic trees from primary data (e.g., DNA sequences originating from some species in X), and then constructing a single phylogenetic tree maximizing the "concordance" with the input trees. The obtained tree is our estimation of the species tree and, when the input trees are defined on overlapping-but not identical-sets of labels, is called "supertree." In this paper, we focus on two problems that are central when combining phylogenetic trees into a supertree: the compatibility and the strict compatibility problems for unrooted phylogenetic trees. These problems are strongly related, respectively, to the notions of "containing as a minor" and "containing as a topological minor" in the graph community. Both problems are known to be fixed parameter tractable in the number of input trees k, by using their expressibility in monadic second-order logic and a reduction to graphs of bounded treewidth. Motivated by the fact that the dependency on k of these algorithms is prohibitively large, we give the first explicit dynamic programming algorithms for solving these problems, both running in time [Formula: see text], where n is the total size of the input.

  6. Pathogenicity and diversity of vegetative compatibility of Fusarium verticillioides

    Directory of Open Access Journals (Sweden)

    Krnjaja Vesna S.


    Full Text Available Pathogenicity of 10 Fusarium verticillioides isolates, originated from grain of wheat (five isolates and maize (five isolates, were studied under greenhouse conditions. Based on different parameters of the pathogenicity estimate (a scale for % of nonemerged plants, % of survived plants, plant vigour - the growth and dry weight of roots and epicotyls and disease severity it was determined that all F. verticillioides isolates expressed a different degree of pathogenicity. According to % of nonemerged plants six three and one F. verticillioides isolates expressed low, moderate and high degree of pathogenicity, respectively. All F. verticillioides isolates reduced the plant survival rate and vigour, while the disease severity ranged from 2.0 to 3.54. Two types of nit mutants, nit1 and NitM, were obtained by the use of the method of vegetative compatibility. The frequency of nit1 mutants was greater (58.79% than the frequency of NitM mutants (5.77%. A total of 10 vegetative compatibility groups (VCGs of F. verticillioides were established in the complementation tests. These results point out to a high genetic diversity of F. verticillioides population.

  7. Altruism and reward: motivational compatibility in deceased organ donation. (United States)

    Voo, Teck Chuan


    Acts of helping others are often based on mixed motivations. Based on this claim, it has been argued that the use of a financial reward to incentivize organ donation is compatible with promoting altruism in organ donation. In its report Human Bodies: Donation for Medicine and Research, the Nuffield Council on Bioethics uses this argument to justify its suggestion to pilot a funeral payment scheme to incentivize people to register for deceased organ donation in the UK. In this article, I cast a sceptical eye on the above Nuffield report's argument that its proposed funeral payment scheme would prompt deceased organ donations that remain altruistic (as defined by and valued the report). Specifically, I illustrate how this scheme may prompt various forms of mixed motivations which would not satisfy the report's definition of altruism. Insofar as the scheme produces an expectation of the reward, it stands diametrical to promoting an 'altruistic perspective'. My minimal goal in this article is to argue that altruism is not motivationally compatible with reward as an incentive for donation. My broader goal is to argue that if a financial reward is used to incentivize organ donation, then we should recognize that the donation system is no longer aiming to promote altruism. Rewarded donation would not be altruistic but it may be ethical given a persistent organ shortage situation.


    Directory of Open Access Journals (Sweden)

    A. Hairmansis


    Full Text Available The F1 hybrid sterility in indica/japonica crosses is the major barrier in developing hybrid rice varieties between these two diverse germplasm. The sterility problem in japonica/indica hybrids can be overcome by using wide compatibility genes. The objective of this study was to identify wide compatibility varieties (WCVs in some tropical japonica rice. Twenty five tropical japonica varieties as male parents were crossed with indica (IR64 and japonica (Akitakomachi testers as female parents. The crosses were planted following a randomized complete block design with three replications. Varieties having average spikelet fertility of more than 70% with both the indica and japonica testers were rated as WCVs. Result from this study showed that six tropical japonica varieties were classified as WCVs, i.e., Cabacu, Grogol, Kencana Bali, Klemas, Lampung Lawer, and Napa. Hybrid sterility is caused by partial sterility of male and female gametes. The WCVs from the present study can be used in hybrid rice breeding program to solve hybrid sterility in indica/japonica hybrids.

  9. Effective Design of Multifunctional Peptides by Combining Compatible Functions. (United States)

    Diener, Christian; Garza Ramos Martínez, Georgina; Moreno Blas, Daniel; Castillo González, David A; Corzo, Gerardo; Castro-Obregon, Susana; Del Rio, Gabriel


    Multifunctionality is a common trait of many natural proteins and peptides, yet the rules to generate such multifunctionality remain unclear. We propose that the rules defining some protein/peptide functions are compatible. To explore this hypothesis, we trained a computational method to predict cell-penetrating peptides at the sequence level and learned that antimicrobial peptides and DNA-binding proteins are compatible with the rules of our predictor. Based on this finding, we expected that designing peptides for CPP activity may render AMP and DNA-binding activities. To test this prediction, we designed peptides that embedded two independent functional domains (nuclear localization and yeast pheromone activity), linked by optimizing their composition to fit the rules characterizing cell-penetrating peptides. These peptides presented effective cell penetration, DNA-binding, pheromone and antimicrobial activities, thus confirming the effectiveness of our computational approach to design multifunctional peptides with potential therapeutic uses. Our computational implementation is available at

  10. A Highest Order Hypothesis Compatibility Test for Monocular SLAM

    Directory of Open Access Journals (Sweden)

    Edmundo Guerra


    Full Text Available Simultaneous Location and Mapping (SLAM is a key problem to solve in order to build truly autonomous mobile robots. SLAM with a unique camera, or monocular SLAM, is probably one of the most complex SLAM variants, based entirely on a bearing-only sensor working over six DOF. The monocular SLAM method developed in this work is based on the Delayed Inverse-Depth (DI-D Feature Initialization, with the contribution of a new data association batch validation technique, the Highest Order Hypothesis Compatibility Test, HOHCT. The Delayed Inverse-Depth technique is used to initialize new features in the system and defines a single hypothesis for the initial depth of features with the use of a stochastic technique of triangulation. The introduced HOHCT method is based on the evaluation of statistically compatible hypotheses and a search algorithm designed to exploit the strengths of the Delayed Inverse- Depth technique to achieve good performance results. This work presents the HOHCT with a detailed formulation of the monocular DI-D SLAM problem. The performance of the proposed HOHCT is validated with experimental results, in both indoor and outdoor environments, while its costs are compared with other popular approaches.

  11. Towards water compatible MIPs for sensing in aqueous media. (United States)

    Horemans, F; Weustenraed, A; Spivak, D; Cleij, T J


    When synthesizing molecularly imprinted polymers (MIPs), a few fundamental principles should be kept in mind. There is a strong correlation between porogen polarity, MIP microenvironment polarity and the imprinting effect itself. The combination of these parameters eventually determines the overall binding behavior of a MIP in a given solvent. In addition, it is shown that MIP binding is strongly influenced by the polarity of the rebinding solvent. Because the use of MIPs in biomedical environments is of considerable interest, it is important that these MIPs perform well in aqueous media. In this article, various approaches are explored towards a water compatible MIP for the target molecule l-nicotine. To this end, the imprinting effect together with the MIP matrix polarity is fine-tuned during MIP synthesis. The binding behavior of the resulting MIPs is evaluated by performing batch rebinding experiments that makes it possible to select the most suitable MIP/non-imprinted polymer couple for future application in aqueous environments. One method to achieve improved compatibility with water is referred to as porogen tuning, in which porogens of varying polarities are used. It is demonstrated that, especially when multiple porogens are mixed, this approach can lead to superior performance in aqueous environments. Another method involves the incorporation of polar or non-polar comonomers in the MIP matrix. It is shown that by carefully selecting these monomers, it is also possible to obtain MIPs, which can selectively bind their target in water.


    Energy Technology Data Exchange (ETDEWEB)

    Bunting, Bruce G [ORNL; Bunce, Michael [ORNL; Barone, Teresa L [ORNL; Storey, John Morse [ORNL


    The purpose of the study described in this report is to summarize the various barriers to more widespread distribution of bio-fuels through our common carrier fuel distribution system, which includes pipelines, barges and rail, fuel tankage, and distribution terminals. Addressing these barriers is necessary to allow the more widespread utilization and distribution of bio-fuels, in support of a renewable fuels standard and possible future low-carbon fuel standards. These barriers can be classified into several categories, including operating practice, regulatory, technical, and acceptability barriers. Possible solutions to these issues are discussed; including compatibility evaluation, changes to bio-fuels, regulatory changes, and changes in the distribution system or distribution practices. No actual experimental research has been conducted in the writing of this report, but results are used to develop recommendations for future research and additional study as appropriate. This project addresses recognized barriers to the wider use of bio-fuels in the areas of development of codes and standards, industrial and consumer awareness, and materials compatibility issues.

  13. Vehicle compatibility in car-to-car collisions : literature review in the framework of the European research project "Improvement of crash compatibility between cars", Workpackage 1.

    NARCIS (Netherlands)

    Sluis, J. van der


    In this report, a literature review is given on the subject of crash compatibility and incompatibility between cars. The study is based on scientific publications on this subject published over the last 15 years. The compatibility problem is described from three points of view: statistical, mechanic

  14. IVVS actuating system compatibility test to ITER gamma radiation conditions

    Energy Technology Data Exchange (ETDEWEB)

    Rossi, Paolo, E-mail: [Associazione EURATOM-ENEA sulla Fusione, 45 Via Enrico Fermi, 00044 Frascati, Rome (Italy); Collibus, M. Ferri de; Florean, M.; Monti, C.; Mugnaini, G.; Neri, C.; Pillon, M.; Pollastrone, F. [Associazione EURATOM-ENEA sulla Fusione, 45 Via Enrico Fermi, 00044 Frascati, Rome (Italy); Baccaro, S.; Piegari, A. [ENEA CR Casaccia, 301 Via Anguillarese, 00123 Santa Maria di Galeria, Rome (Italy); Damiani, C.; Dubus, G. [Fusion For Energy c/Josep Pla, n° 2 Torres Diagonal Litoral, 08019 Barcelona (Spain)


    Highlights: • ENEA developed and tested a prototype of a laser In Vessel Viewing and ranging System (IVVS) for ITER. • One piezo-motor prototype has been tested on the ENEA Calliope gamma irradiation facility to verify its compatibility to ITER gamma radiation conditions. • After a total dose of more than 4 MGy the piezo-motor maintained almost the same working parameters monitored before test without any evident and significant degradation of functionality. • After the full gamma irradiation test, the same piezo-motor assembly will be tested with 14 MeV neutrons irradiation using ENEA FNG facility. -- Abstract: The In Vessel Viewing System (IVVS) is a fundamental remote handling equipment, which will be used to make a survey of the status of the blanket first wall and divertor plasma facing components. A design and testing activity is ongoing, in the framework of a Fusion for Energy (F4E) grant agreement, to make the IVVS probe design compatible with ITER operating conditions and in particular, but not only, with attention to neutrons and gammas fluxes and both space constraints and interfaces. The paper describes the testing activity performed on the customized piezoelectric motors and the main components of the actuating system of the IVVS probe with reference to ITER gamma radiation conditions. In particular the test is performed on the piezoelectric motor, optical encoder and small scale optical samples .The test is carried out on the ENEA Calliope gamma irradiation facility at ITER relevant gamma fields at rate of about 2.5 kGy/h and doses of 4 MGy. The paper reports in detail the setup arrangement of the test campaign in order to verify significant working capability of the IVVS actuating components and the results are shown in terms of functional performances and parameters. The overall test campaign on IVVS actuating system will be completed on other ENEA testing facilities in order to verify compatibility to Magnetic field, neutrons and thermal

  15. Genetic differentiation among sexually compatible relatives of Brassica napus L.

    Directory of Open Access Journals (Sweden)

    Pipan Barbara


    Full Text Available Analysis of gene flow between Brassica napus L. and its sexually compatible relatives that could be found in the wild in Slovenia was performed by microsatellite analysis using fifteen selected primer pairs. Genotypes included in the study were obtained from the field survey of sexually compatible relatives of B. napus in natural habitats around Slovenia and from reference collections. Two different wild species of all the presented sexually compatible relatives of B. napus were found in Slovenia, B. rapa and Sinapis arvensis. The reference genotypes included varieties and wild forms from internal collections as marketable seeds or from gene banks. Reference genotypes were represented by the following species and subspecies: B. napus ssp. napobrassica, B. napus ssp. napus, B. nigra, B. oleracea, B. rapa ssp. oleifera, Diplotaxis muralis; D. tenuifolia, Raphanus raphanistrum, R. sativus, R. sativus var. oleiformis, Rapistrum rugosum, S. alba and S. arvensis. Estimation of gene flow described by average number of migrants was 0.72 followed by 0.20 migrants. Due to the observed gene migrations, genetic drift and selection, Hardy-Weinberg equilibrium was not met. The mean number of alleles over all loci was 16.9, the average polymorphic information content was 0.43. We found four highly divergent and polymorphic loci (Na12-C08, Na10-A08, Ni3-G04b and BRMS-050 at statistically significant level (p<0.05 of gene flow detected. Over all gene diversity intra-individual among populations (0.55 was lower than inter-individual among population (0.77. The results of genetic linkages based standard genetic distance and unweighted pair group method with arithmetic mean clustering method, generally divided the genotypes in three divergent groups. Similar results were obtained by principal coordinate analysis where three main groups were constructed according to three factors. A real number of genetic clusters demonstrated a clear separation between populations

  16. Highly efficient and compatible shampoo for use after hair transplant

    Directory of Open Access Journals (Sweden)

    Schweiger D


    Full Text Available Dorothea Schweiger,1 Andrea M Schoelermann,1 Alexander Filbry,1 Tina Hamann,1 Claudia Moser,2 Frank Rippke1 1Research and Development, Beiersdorf AG, Hamburg, Germany; 2Moser Medical, Clinics for Aesthetic Plastic Surgery, Vienna, Austria Background: Sensitive or hyperreactive skin is a common condition defined by prickling, burning, pain, and pruritus. Although this skin problem was initially described on the face, the scalp is often affected. A sensitive scalp can react with irritation to harsh surfactants or other additives which are often present in shampoos. For this reason, we developed a new rinse-off hypertolerant shampoo specifically designed for the hypersensitive and problematic scalp.Methods: The shampoo formulation is based on an extremely mild surfactant system and contains bisabolol, an anti-irritant and anti-inflammatory ingredient of chamomile. The shampoo is free of additives such as perfumes, silicones, colorants, parabens, paraffins, and betaine. Since skin can remain in a hyperreactive state after wounding, the status after hair transplantation was chosen as a model system to test the shampoo. Scalp condition and compatibility of each volunteer were analyzed by a plastic surgeon directly after hair transplant and after stitch removal. The plastic surgeons also rated whether they would recommend the further use of the test shampoo. Additionally, volunteers completed a self-assessment questionnaire.Results: Following hair transplantation, regular use of the shampoo resulted in a significant reduction in the extent of scabbing and erythema. This was confirmed by dermatological scalp examinations performed by the plastic surgeon as well as in volunteers' self-assessments. The plastic surgeon highly recommended the further use of the test shampoo after hair transplant to all study participants.Conclusion: Application of the test shampoo demonstrated excellent skin compatibility and product efficacy after hair transplant. The test

  17. Spectral_Engineering_with_CMOS_compatible_SOI_Photonic_Molecules

    CERN Document Server

    Barea, Luis A M; de Rezende, Guilherme F M; Frateschi, Newton C


    Photonic systems based on microring resonators have a fundamental constrain given by the strict relationship among free spectral range (FSR), total quality factor (QT) and resonator size, intrinsically making filter spacing, photonic lifetime and footprint interdependent. Here we break this paradigm employing CMOS compatible Silicon-on-Insulator (SOI) photonic molecules based on coupled multiple ring resonators. The resonance wavelengths and their respective linewidths are controlled by the hybridization of the quasi-orthogonal photonic states. We demonstrate photonic molecules with doublet and triplet resonances with spectral spliting only achievable with single rings orders of magnitude larger in foot print. Besides, these splitting are potentially controllable based on the coupling (bonds) between resonators. Finally, the spatial distribution of the hybrid states allows up to sevenfold QT enhancement.

  18. Energetics and Compatibility of Plasticizers in Composite Solid Propellants

    Directory of Open Access Journals (Sweden)

    Rm. Muthiah


    Full Text Available In this paper a comparative analysis on the energetics of ester type plasticizers such as dioctyl adipate (DOA, dioctyl phthalate (DOP,dibutyl sebacate (DBS, isodecyl pelargonate (IDP, trioctylphosphate (TOF, diethyl phthalate (DEP, tricresyl phosphate (TCPand dibutyl phthalate (DBP and hydrocarbon type plasticizers such as polybutene (PB, spindle oil, naphthenic oil, polymer extender oil(PEO and poly isobutylene (PIB and the impact of some of the plasticizers on the work ability, pot life and mechanical properties of propellants based on two selected polymeric binders namely polybutadiene-acrylic acid-acrylonitrile (PBAN ter polymer andhydroxyl terminated polybutadiene (HTPB have been reported. The compatibility of all the plasticizers on HTPB binder was also studied at different concentration levels and temperatures using Brookfield viscometer and reported. The mechanism of plasticization is also reviewed.

  19. Cellular compatibility of improved scaffold material with deproteinized heterogeneous bone

    Institute of Scientific and Technical Information of China (English)

    LIU Lei; PEI Fu-xing; ZHOU Zong-ke; LI Qi-hong


    Objective:To study cellular compatibility of improved scaffold material with deproteinized heterogeneous bone and provide experimental basis on choosing the scaffold material in bone tissue engineering.Methods: Bone marrow stromal cells (BMSC) were co-cultured with heterogeneous deproteinized bone in vitro. The contrast phase microscope, scanning electron microscope, MTT assay, flow cytometry were performed and the BGP content and ALP activities were detected in order to observe the cell growth, adhesion in the material, cell cycle and cell viability.Results: The scaffold material of deproteinized heterogeneous bone had no inhibitory effect on cellular proliferation, differentiation and secretion function of BMSCs.Conclusions: The established heterogeneous deproteinized bone has good biocompatibility with BMSCs and is a potentially ideal scaffold material for bone tissue engineering.

  20. Ischemic preconditioning in immature hearts: mechanism and compatibility with cardioplegia

    Institute of Scientific and Technical Information of China (English)

    朱斌; 闵苏; 龙村; 叶铁虎


    Objective To investigate (1) whether ischemic preconditioning (IPC) could protect immature rabbit hearts against ischemia-reperfusion injury and (2) the role of KATP channel in the mechanism of myocardial protection. Since cardioplegia is a t raditional and effective cardioprotective measure in clinic, our study is also d esigned to probe the compatibility between IPC and cardioplegia.Results The recovery of CF, HR, LVDP and ±dp/dtmax in preconditioned hearts was b est am ong the four groups. The incidence of arrhythmia was low and less CK-MB leaked out in the IPC group. Myocardial ATP content was better preserved by IPC. Pre treatment with glibenclamide completely abolished the myocardial protection prov ided by IPC, but did not affect ischemia-reperfusion injury.Conclusions While applying cardioplegia, IPC provides significant cardioprotective effects. Activation of KATP channels is involved in the mechanism of IPC-produced cardioprotection.

  1. New CMOS Compatible Platforms for Integrated Nonlinear Optical Signal Processing

    CERN Document Server

    Moss, D J


    Nonlinear photonic chips have succeeded in generating and processing signals all-optically with performance far superior to that possible electronically - particularly with respect to speed. Although silicon-on-insulator has been the leading platform for nonlinear optics, its high two-photon absorption at telecommunications wavelengths poses a fundamental limitation. This paper reviews some of the recent achievements in CMOS-compatible platforms for nonlinear optics, focusing on amorphous silicon and Hydex glass, highlighting their potential future impact as well as the challenges to achieving practical solutions for many key applications. These material systems have opened up many new capabilities such as on-chip optical frequency comb generation and ultrafast optical pulse generation and measurement.

  2. Compatibility between pipeline mainline and girth-weld coatings

    Energy Technology Data Exchange (ETDEWEB)

    Papavinasam, S.; Doiron, A.


    Coatings and cathodic protection (CP) are used to protect pipelines against external corrosion and stress corrosion cracking (SCC). This paper discussed a research study currently being implemented to test the compatibility of girth-weld coatings with fusion-bonded epoxy (FBE) mainline coatings. The study is part of a larger research project initiated to develop standards and standard tests for coating performance. The pipeline samples will be conditioned for a 6 month period and subjected to impact; flexibility; adhesion; cathodic disbondment; squeeze; ice adhesion; and peel tests. Various coating samples will be prepared removing mainline coatings in certain parts of the pipes and replacing them with girth-weld coatings. Results of the study will be used to obtain feedback from industry and stakeholders in relation to the development of standards and further studies. 9 refs., 5 tabs., 1 appendix.

  3. Flight management concepts compatible with air traffic control (United States)

    Morello, S. A.


    With the advent of airline deregulation and increased competition, the need for cost efficient airline operations is critical. This paper summarizes past research efforts and planned research thrusts toward the development of compatible flight management and air traffic control systems that promise increased operational effectiveness and efficiency. Potential capacity improvements resulting from a time-based ATC simulation (fast-time) are presented. Advanced display concepts with time guidance and velocity vector information to allow the flight crew to play an important role in the future ATC environment are discussed. Results of parametric sensitivity analyses are also presented that quantify the fuel/cost penalties for idle-thrust mismodeling and wind-modeling errors.

  4. Compatibility of detached divertor operation with robust edge pedestal performance

    Energy Technology Data Exchange (ETDEWEB)

    Leonard, A.W., E-mail: [General Atomics, PO Box 85608, San Diego, CA 92186-5608 (United States); Makowski, M.A.; McLean, A.G. [Lawrence Livermore National Laboratory, Livermore, CA (United States); Osborne, T.H.; Snyder, P.B. [General Atomics, PO Box 85608, San Diego, CA 92186-5608 (United States)


    The compatibility of detached radiative divertor operation with a robust H-mode pedestal is examined in DIII-D. A density scan produced low temperature plasmas at the divertor target, T{sub e} ⩽ 2 eV, with high radiation leading to a factor of ⩾4 drop in peak divertor heat flux. The cold radiative plasma was confined to the divertor and did not extend across the separatrix in X-point region. A robust H-mode pedestal was maintained with a small degradation in pedestal pressure at the highest densities. The response of the pedestal pressure to increasing density is reproduced by the EPED pedestal model. However, agreement of the EPED model with experiment at high density requires an assumption of reduced diamagnetic stabilization of edge Peeling–Ballooning modes.

  5. Heparin coatings for improving blood compatibility of medical devices. (United States)

    Biran, Roy; Pond, Daniel


    Blood contact with biomaterials triggers activation of multiple reactive mechanisms that can impair the performance of implantable medical devices and potentially cause serious adverse clinical events. This includes thrombosis and thromboembolic complications due to activation of platelets and the coagulation cascade, activation of the complement system, and inflammation. Numerous surface coatings have been developed to improve blood compatibility of biomaterials. For more than thirty years, the anticoagulant drug heparin has been employed as a covalently immobilized surface coating on a variety of medical devices. This review describes the fundamental principles of non-eluting heparin coatings, mechanisms of action, and clinical applications with focus on those technologies which have been commercialized. Because of its extensive publication history, there is emphasis on the CARMEDA(®) BioActive Surface (CBAS(®) Heparin Surface), a widely used commercialized technology for the covalent bonding of heparin.

  6. Environmental compatibility of CRYOPLANE the cryogenic-fuel aircraft

    Energy Technology Data Exchange (ETDEWEB)

    Klug, H.G. [Daimler Benz Aerospace Airbus, Hamburg (Germany)


    `CRYOPLANE` is the project name for an aircraft powered by cryogenic fuel, either liquid natural gas (LNG, mainly consisting of methane) or liquid hydrogen (LH{sub 2}). Emission of CO{sub 2}, unburnt hydrocarbons, soot and sulfur will be completely avoided by hydrogen combustion: LH{sub 2} is an extremely pure liquid. Emission of water as a primary combustion product is increased by a factor of 2.6. Exhaust gases behind hydrogen engines contain more water than behind kerosene engines, and hence can form contrails under a wider range of atmospheric conditions. Liquid hydrogen fueled aircraft promise big advantages relative to kerosene aircraft in terms of environmental compatibility. (R.P.)

  7. Microfluidics and multielectrode array-compatible organotypic slice culture method. (United States)

    Berdichevsky, Yevgeny; Sabolek, Helen; Levine, John B; Staley, Kevin J; Yarmush, Martin L


    Organotypic brain slice cultures are used for a variety of molecular, electrophysiological, and imaging studies. However, the existing culture methods are difficult or expensive to apply in studies requiring long-term recordings with multielectrode arrays (MEAs). In this work, a novel method to maintain organotypic cultures of rodent hippocampus for several weeks on standard MEAs in an unmodified tissue culture incubator is described. Polydimethylsiloxane (Sylgard) mini-wells were used to stabilize organotypic cultures on glass and MEA surfaces. Hippocampus slices were successfully maintained within PDMS mini-wells for multiple weeks, with preserved pyramidal layer organization, connectivity, and activity. MEAs were used to record the development of spontaneous activity in an organotypic cultures for 4 weeks. This method is compatible with integration of microchannels into the culture substrate. Microchannels were incorporated into the mini-wells and applied to the guidance of axons originating within the slice, paving the way for studies of axonal sprouting using organotypic slices.

  8. Platforms for integrated nonlinear optics compatible with silicon integrated circuits

    CERN Document Server

    Moss, David J


    Nonlinear photonic chips are capable of generating and processing signals all-optically with performance far superior to that possible electronically - particularly with respect to speed. Although silicon has been the leading platform for nonlinear optics, its high two-photon absorption at telecommunications wavelengths poses a fundamental limitation. We review recent progress in CMOS-compatible platforms for nonlinear optics, focusing on Hydex glass and silicon nitride and briefly discuss the promising new platform of amorphous silicon. These material systems have opened up many new capabilities such as on-chip optical frequency comb generation, ultrafast optical pulse generation and measurement. We highlight their potential future impact as well as the challenges to achieving practical solutions for many key applications.

  9. Bimode uninterruptible power supply compatibility in renewable hybrid energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Bower, W. (Sandia National Labs., Albuquerque, NM (USA)); O' Sullivan, G. (Abacus Controls, Inc., Somerville, NJ (USA))


    Inverters installed in renewable hybrid energy systems are typically used in a stand-alone mode to supply ac power to loads from battery storage when the engine-generator is not being used. Similarities in topology and in the performance requirements of the standby uninterruptible power supply (UPS) system and the hybrid system suggest the UPS could be used in hybrid energy systems. Another alternative to inverters with add-on charging circuits or standby UPS hardware is the Bimode UPS. The bimode UPS uses common circuitry and power components for dc to ac inversion and battery charging. It also provides an automatic and nearly instantaneous ac power transfer function when the engine-generator is started or stopped. The measured operating and transfer characteristics of a bimode UPS in a utility system and in a hybrid system are presented. The applicability of the bimode UPS to hybrid systems and its compatibility in a PV/engine-generator hybrid system are given.

  10. Rate Compatible Protocol for Information Reconciliation: An application to QKD

    CERN Document Server

    Elkouss, David; Lancho, Daniel; Martin, Vicente


    Information Reconciliation is a mechanism that allows to weed out the discrepancies between two correlated variables. It is an essential component in every key agreement protocol where the key has to be transmitted through a noisy channel. The typical case is in the satellite scenario described by Maurer in the early 90's. Recently the need has arisen in relation with Quantum Key Distribution (QKD) protocols, where it is very important not to reveal unnecessary information in order to maximize the shared key length. In this paper we present an information reconciliation protocol based on a rate compatible construction of Low Density Parity Check codes. Our protocol improves the efficiency of the reconciliation for the whole range of error rates in the discrete variable QKD context. Its adaptability together with its low interactivity makes it specially well suited for QKD reconciliation.

  11. Biomedical Nanoparticles: Overview of Their Surface Immune-Compatibility

    Directory of Open Access Journals (Sweden)

    Olimpia Gamucci


    Full Text Available Diagnostic- and therapeutic release-aimed nanoparticles require the highest degree of biocompatibility. Some physical and chemical characteristics of such nanomaterials are often at odds with this requirement. For instance, metals with specific features used as contrast agents in magnetic resonance imaging need particular coatings to improve their blood solubility and increase their biocompatibility. Other examples come from the development of nanocarriers exploiting the different characteristics of two or more materials, i.e., the ability to encapsulate a certain drug by one core-material and the targeting capability of a different coating surface. Furthermore, all these “human-non-self” modifications necessitate proofs of compatibility with the immune system to avoid inflammatory reactions and resultant adverse effects for the patient. In the present review we discuss the molecular interactions and responses of the immune system to the principal nanoparticle surface modifications used in nanomedicine.

  12. A negative compatibility effect in priming of emotional faces. (United States)

    Bennett, Jennifer D; Lleras, Alejandro; Oriet, Chris; Enns, James T


    The negative compatibility effect (NCE) is the surprising result that low-visibility prime arrows facilitate responses to opposite-direction target arrows. Here we compare the priming obtained with simple arrows to the priming of emotions when categorizing human faces, which represents a more naturalistic set of stimuli and for which there are no preexisting response biases. When inverted faces with neutral expressions were presented alongside emotional prime and target faces, only strong positive priming occurred. However, when the neutral faces were made to resemble the target faces in geometry (upright orientation), time (flashing briefly), and space (appearing in the same location), positive priming gradually weakened and became negative priming. Implications for theories of the NCE are discussed.

  13. Surface engineering of polycaprolactone by biomacromolecules and their blood compatibility. (United States)

    Khandwekar, Anand P; Patil, Deepak P; Shouche, Yogesh; Doble, Mukesh


    Improving blood compatibility of biodegradable polymers is an area of intensive research in blood contacting devices. In this study, curdlan sulphate and heparin-modified poly (caprolactone) (PCL) hybrids were developed by physically entrapping these molecules on the PCL surface. This modification technique was performed by reversible gelation of the PCL surface region following exposure to a solvent and nonsolvent mixture. The presence of these biomacromolecules on the PCL surface was verified by atomic force microscopy (AFM) and scanning electron microscopy and energy dispersive X-ray analysis (SEM-EDAX) analysis, while wettability of the films was investigated by dynamic contact angle measurements. The blood compatibilities of the surface-modified films were examined using in vitro platelet and leukocyte adhesion and thrombus formation. Mouse RAW 264.7 macrophage cells were used to assess the cell adhesion and inflammatory response to the modified surface by quantifying mRNA expression levels of proinflammatory cytokines namely TNF-α and IL-1β using real-time polymerase chain reaction (RT-PCR). A lower platelet and leukocyte adhesion and activation was observed on the modified films incubated with whole human blood for 2 h. The thrombus formation on the PCL was significantly decreased upon immobilization of both curdlan sulphate (39%, *pcompatibility was obtained by surface entrapment of both curdlan sulphate (CURS) and heparin (HEP) onto PCL films. Both PCL-CURS and PCL-HEP films reduced RAW 264.7 macrophage cell adhesion (*pcompatibility and reduced inflammatory host response for its future blood contacting applications.

  14. LED lamps in shipboard lighting systems: Aspects of electromagnetic compatibility

    Directory of Open Access Journals (Sweden)

    Beley V. F.


    Full Text Available Trends in the development of different types of light sources and their energy characteristics have been described in the paper. Analysis of regulatory documents has been given. The results of experimental studies of a number of modern LED lamps have been described. Investigation has been made for a number of LED lamps produced by Philips, Xavax and Melitec. The experimental data have been obtained with the complex of devices: the dual-channel oscilloscope (GDS-71042, the power quality analyzer (Fluke-434 and the multi-function device EcoLight-01 (light-, pulse- and luminance meter. It has been shown that operation of LED lamps is characterized by emission of higher current harmonics and reactive power consumption, which depends on the type and design of the lamp driver. It has been found that the value of luminance created by LED lamps in case of acceptable (for ships prolonged deviation of voltage (–10 % is reduced by 3 %; in case of permissible short-term voltage deviation (–20 % luminance is reduced by 7 %. For incandescent lamps this indicator is characterized by a decrease in luminance by 40 % and 60 %, respectively. Despite the low sensitivity to voltage changes (in comparison with other types of lamps, the operation of LED lamps is also associated with the appearance of flicker. Absence of limitations for fluctuations of the light flux in shipboard lighting systems and imperfection of methods for determining the flicker make it difficult to ensure electromagnetic compatibility of LED lamps. Therefore due to reliability, environmental friendliness, energy efficiency and lumen maintenance LED lamps have prospects for introduction into shipboard lighting systems. However, to ensure electromagnetic compatibility of LED lighting systems it is necessary to conduct a detailed study of energy characteristics of LED lamps and to develop appropriate regulatory requirements and technical solutions.

  15. Compatibility of materials with liquid metal targets for SNS

    Energy Technology Data Exchange (ETDEWEB)

    DiStefano, J.R.; Pawel, S.J.; DeVan, J.H.


    Several heavy liquid metals are candidates as the target in a spallation neutron source: Hg, Pb, Bi, and Pb-Bi eutectic. Systems with these liquid metals have been used in the past and a data-base on compatibility already exists. Two major compatibility issues have been identified when selecting a container material for these liquid metals: temperature gradient mass transfer and liquid metal embrittlement or LME. Temperature gradient mass transfer refers to dissolution of material from the high temperature portions of a system and its deposition in the lower temperature areas. Solution and deposition rate constants along with temperature, {Delta}T, and velocity are usually the most important parameters. For most candidate materials mass transfer corrosion has been found to be proportionately worse in Bi compared with Hg and Pb. For temperatures to {approx}550{degrees}C, ferritic/martensitic steels have been satisfactory in Pb or Hg systems and the maximum temperature can be extended to {approx}650{degrees}C with additions of inhibitors to the liquid metal, e.g. Mg, Ti, Zr. Above {approx}600{degrees}C, austenitic stainless steels have been reported to be unsatisfactory, largely because of the mass transfer of nickel. Blockage of flow from deposition of material is usually the life-limiting effect of this type of corrosion. However, mass transfer corrosion at lower temperatures has not been studied. At low temperatures (usually < 150{degrees}C), LME has been reported for some liquid metal/container alloy combinations. Liquid metal embrittlement, like hydrogen embrittlement, results in brittle fracture of a normally ductile material.

  16. Immunological compatibility between the chacma baboon and man. (United States)

    Stark, J H; Smit, J A; Neethling, F A; Nortman, P J; Myburgh, J A


    Predictions of an increasing shortage of donor organs for the future has led to a resurgence of interest in xenotransplantation. We have methodically assessed the immunological compatibility of humans against the chacma baboon with a view to narrowing the gap of concordance by careful immunological screening. The necessity of major blood group compatibility in xenotransplantation is now established. While no group O universal donor exists in the baboon, groups A (45%), B (15%), and AB (40%) are well represented. Baboon histocompatibility antigens could not be precisely defined using human antisera. This does not necessarily imply lack of homology between the species, as we have shown specific crossreactivity of numerous antihuman monoclonal antibodies with baboon leukocytes. Normal humans do not exhibit preformed agglutinins to erythrocytes of the chacma baboon (Papio ursinus orientalis)) but cytotoxic antibodies are occasionally found. Sera from allosensitized patients may contain crossreacting hemagglutinins, leukoagglutinins and complement-dependent cytotoxic antibodies. Binding of human immunoglobulin-G and -M to baboon targets was demonstrated by flow cytometry. Negative crossmatch combinations for antibodies of the IgG subclass were easily found, but IgM antibodies from allosensitized patients were polyspecific in their action. In vitro assessment of lymphocyte mediated cytotoxicity showed that preformed cellular immunity between the species was rare. The response of human lymphocytes to xenoantigen stimulation in mixed lymphocyte cultures showed a normal distribution, permitting the selection of low-responding combinations. Screening for viruses, especially HTLV-1 and Coxsackie-BL34, is important. These findings demonstrate a closer degree of concordance than has previously been suspected.

  17. Bioactive and thermally compatible glass coating on zirconia dental implants. (United States)

    Kirsten, A; Hausmann, A; Weber, M; Fischer, J; Fischer, H


    The healing time of zirconia implants may be reduced by the use of bioactive glass coatings. Unfortunately, existing glasses are either bioactive like Bioglass 45S5 but thermally incompatible with the zirconia substrate, or they are thermally compatible but exhibit only a very low level of bioactivity. In this study, we hypothesized that a tailored substitution of alkaline earth metals and alkaline metals in 45S5 can lead to a glass composition that is both bioactive and thermally compatible with zirconia implants. A novel glass composition was analyzed using x-ray fluorescence spectroscopy, dilatometry, differential scanning calorimetry, and heating microscopy to investigate its chemical, physical, and thermal properties. Bioactivity was tested in vitro using simulated body fluid (SBF). Smooth and microstructured glass coatings were applied using a tailored spray technique with subsequent thermal treatment. Coating adhesion was tested on implants that were inserted in bovine ribs. The cytocompatibility of the coating was analyzed using L929 mouse fibroblasts. The coefficient of thermal expansion of the novel glass was shown to be slightly lower (11.58 · 10(-6) K(-1)) than that of the zirconia (11.67 · 10(-6) K(-1)). After storage in SBF, the glass showed reaction layers almost identical to the bioactive glass gold standard, 45S5. A process window between 800 °C and 910 °C was found to result in densely sintered and amorphous coatings. Microstructured glass coatings on zirconia implants survived a minimum insertion torque of 60 Ncm in the in vitro experiment on bovine ribs. Proliferation and cytotoxicity of the glass coatings was comparable with the controls. The novel glass composition showed a strong adhesion to the zirconia substrate and a significant bioactive behavior in the SBF in vitro experiments. Therefore, it holds great potential to significantly reduce the healing time of zirconia dental implants.

  18. Container-content compatibility studies: a pharmaceutical team's integrated approach. (United States)

    Laschi, Alda; Sehnal, Natacha; Alarcon, Antoine; Barcelo, Beatrice; Caire-Maurisier, François; Delaire, Myriam; Feuilloley, Marc; Genot, Stéphanie; Lacaze, Catherine; Pisarik, Luc; Smati, Christophe


    Container-content compatibility studies are required as part of the submission of a new product market authorization file or for a change relating to the primary product-contact packaging. Many regulatory publications and guidances are available in the USA, Europe, and Japan. However these publications and guidances are not sufficiently precise enough to allow for consistent interpretation and implementation of the technical requirements. A working group has been formed by the French Society of Pharmaceutical Science and Technology (SFSTP) in order to propose guidance for container-content interaction studies that meet both European and US requirements, and allows consistent and standardized information to be presented by the industry to the regulators. When a pharmaceutical drug product remains in prolonged contact with a material, the two critical points to consider are the drug product's quality and safety. A pharmaceutical evaluation of the container-content relationship should be done based on the knowledge of the contact material (e.g., type, physicochemical properties), its manufacturing processes (e.g., the type of sterilization that could potentially alter the interactions), and the formulation components involved in contact with this material (e.g., physicochemical properties, pharmaceutical presentation, route of administration). Quality is evaluated using the stability study performed on the product. Safety is partially evaluated with the stability study and is analyzed in conjunction with toxicity testing, specifically with cytotoxicity testing. The toxicity aspect is the key point of the container-content compatibility study and of patient safety. Migration tests are conducted when an interaction is suspected, or found based on previous results, to identify the component responsible for this interaction and to help select a new material if needed. Therefore, such tests are perhaps not the best ones to use for the purpose of safety evaluation

  19. Microwave/mm wave magnetics and MMIC compatibility (invited) (abstract) (United States)

    Adam, J. D.


    Ferrite devices can be loosely classified into three different categories, namely: control components using polycrystalline ferrites, tunable filters and oscillators using YIG spheres, and devices based on epitaxial YIG or ferrite films. Ferrite control components such as circulators, isolators, and switches are used in almost all microwave and millimeter wave systems. Tunable YIG sphere devices see more limited use in radar and EW systems, and microwave test equipment while epitaxial YIG devices have yet to make a significant systems impact. GaAs chips for phased array modules are under development by several companies for both radar and EW applications. The GaAs chips can contain small signal and power gain, phase shifters, filters, mixers, and switches. The modules are usually designed, however, with discrete circulators or isolators which are often significantly larger than the MMIC chips. Further reduction in module size and cost will require the design of the module without nonreciprocal components, or the development of ferrite devices which are more compatible with the size, bandwidth, and fabrication of the GaAs device. Integration of nonreciprocal ferrite components on the GaAs chip could have a large impact but presents a significant challenge both in terms of processing compatibility between the ferrite and the GaAs and in terms of cost. The impact in the areas of tunable YIG filters and oscillators and MSW devices are smaller but, fortunately, so are the difficulties. Here the YIG films or spheres, or hexagonal ferrite films can be laid on the GaAs substrate thus forming a hybrid device. Having integrated the ferrite with the GaAs it is necessary to consider the magnetic bias field requirement. Bias fields are not required in latching devices and can be minimized in other devices by use of hexagonal ferrite films with their large anisotropy fields. It may even be possible to integrate a permanent magnet film onto the GaAs chip.

  20. Is compatible the idea of incommensurability with that of scientific progress? Some reasons in support of its compatibility [Spanish

    Directory of Open Access Journals (Sweden)

    Juan Manuel Jaramillo Uribe


    Full Text Available The problem of incommensurability and, particulary, the one of the scientific progress, is associated two names: Kuhn and Feyerabend, whose proposals caused than many put in doubt the apparent evidence of the call scientific progress, relativizing its validity to each school or paradigm. In this writing we will show that this type of epistemic relativism —just as convergentist theory of the truth— they lack of philosophical validity and historical and how the idea of scientific progress is compatible with the thesis of the incommensurability beyond the ontosemantics difficulties that it implies. This suppose to leave the the call statement view of the scientific theories and adopt a non-statement view where the intertheoretical relation of approach allows to subsink different non trivial incommensurability and to validate in them the notion oaf scientific progress.

  1. Compatibility Decisions, Endogenous Installed Home Bases and the Third-Market Competition


    Walz, Uwe; Woeckener, Bernd


    This Paper analyses the compatibility decisions of two regional monopolistic suppliers of a network-effect good who first build up installed bases in their respective home region and then compete in a third market. We show that with weak network effects, installed home bases always are higher under compatibility and suppliers always opt for compatibility. With strong network effects, home markets are covered, and given a sufficiently high home-market size advantage both the favoured supplier ...

  2. Development of Recycling Compatible Pressure-Sensitive Adhesives and Coatings

    Energy Technology Data Exchange (ETDEWEB)

    Steven J. Severtson


    The objective of this project was the design of new water-based pressure-sensitive adhesive (PSA) products and coatings engineered for enhanced removal during the processing of recycled fiber. Research included the formulation, characterization, and performance measurements of new screenable coatings, testing of modified paper and board substrates and the design of test methods to characterize the inhibition of adhesive and coating fragmentation and relative removal efficiencies of developed formulations. This project was operated under the requirements that included commercially viable approaches be the focus, that findings be published in the open literature and that new strategies could not require changes in the methods and equipment used to produce PSA and PS labels or in the recycling process. The industrial partners benefited through the building of expertise in their company that they would not, and likely could not, have pursued if it had not been for the partnership. Results of research on water-based PSAs clearly identifies which PSA and paper facestock properties govern the fragmentation of the adhesive and provide multiple strategies for making (pressure-sensitive) PS labels for which the PSA is removed at very high efficiencies from recycling operations. The application of these results has led to the identification of several commercial products in Franklin International’s (industrial partner) product line that are recycling compatible. Several new formulations were also designed and are currently being scaled-up. Work on recycling compatible barrier coatings for corrugated containers examined the reinforcement of coatings using a small amount of exfoliated organically modified montmorillonite (OMMT). These OMMT/paraffin wax nanocomposites demonstrated significantly improved mechanical properties. Paraffin waxes containing clay were found to have significantly higher Young’s moduli and yield stress relative to the wax matrix, but the most

  3. Carrier Analysis Lab (CAL) – Aircraft/Weapons/Ship Compatibility Lab (United States)

    Federal Laboratory Consortium — Purpose: The Carrier Analysis Lab (CAL) - Aircraft/Weapons/Ship Compatibility Lab located at the Naval Air Warfare Center Aircraft Division, Lakehurst, NJ provides...

  4. Communications, Navigation, and Network Reconfigurable Test-bed Flight Hardware Compatibility Test S (United States)


    Communications, Navigation, and Network Reconfigurable Test-bed Flight Hardware Compatibility Test Sets and Networks Integration Management Office Testing for the Tracking and Data Relay Satellite System

  5. HTS compatible assay for antioxidative agents using primary cultured hepatocytes. (United States)

    Gaunitz, Frank; Heise, Kerstin


    We have used primary cultured rat hepatocytes to establish a system that is compatible with HTS for screening substance libraries for biologically active compounds. The hepatocytes were treated with t-BHP to induce oxidative stress, leading to the formation ROS. The involvement of ROS in oxidative stress and pathological alterations has been of major interest in recent years, and there is great demand to identify new compounds with antioxidant potential. In most HTS programs each compound is tested in duplicate, and may only be tested once. Because of this it is important to develop assays that can identify candidate compounds accurately and with high confidence. Using newly available cell-based assay systems, we have developed a system that can detect active compounds (hits) with a high degree of confidence. As an example of an agent that can be detected from a substance library, we analyzed the effect of fisetin as an antioxidative compound using this system. All measurements were performed using the newly developed and highly versatile Multilabel-Reader Mithras LB 940 (Berthold Technologies, Bad Wildbad, Germany). The data presented show that all Z' factors determined were highly reliable. Although the protocol is primarily designed to screen for substances with antioxidative potential, it can easily be adapted to screen for other biologically active substances.

  6. A magnetic-resonance-imaging-compatible remote catheter navigation system. (United States)

    Tavallaei, Mohammad Ali; Thakur, Yogesh; Haider, Syed; Drangova, Maria


    A remote catheter navigation system compatible with magnetic resonance imaging (MRI) has been developed to facilitate MRI-guided catheterization procedures. The interventionalist's conventional motions (axial motion and rotation) on an input catheter - acting as the master - are measured by a pair of optical encoders, and a custom embedded system relays the motions to a pair of ultrasonic motors. The ultrasonic motors drive the patient catheter (slave) within the MRI scanner, replicating the motion of the input catheter. The performance of the remote catheter navigation system was evaluated in terms of accuracy and delay of motion replication outside and within the bore of the magnet. While inside the scanner bore, motion accuracy was characterized during the acquisition of frequently used imaging sequences, including real-time gradient echo. The effect of the catheter navigation system on image signal-to-noise ratio (SNR) was also evaluated. The results show that the master-slave system has a maximum time delay of 41 ± 21 ms in replicating motion; an absolute value error of 2 ± 2° was measured for radial catheter motion replication over 360° and 1.0 ± 0.8 mm in axial catheter motion replication over 100 mm of travel. The worst-case SNR drop was observed to be 2.5%.


    Institute of Scientific and Technical Information of China (English)

    Jian CHEN; Nan ZHANG; Shuo HUANG


    This paper studies a service firm whose business time can be divided into several periods,each providing different value to customers.Heterogeneous service is a major reason resulting in imbalances between supply and demand.Since customers differ in their degree of impatience,firms Can use differential pricing mechanisms to optimize their objectives and match supply with demand in each period,by inducing customers to choose different periods.We study two types of firms,an internal firm,the objective of which is to maximize the system's(including the firm and all the customers)total net value,and a commercial firm,which aims to optimize its own profit.Though impatience factors are customers'private information,for each type of firm,we derive the optimal incentive compatible pricing policy,under which all the coming customers will follow the firm's assignment,that is,patient customers will buy the service in high-value periods,but their waiting time will be longer,while impatient customers will enter into the low-value periods,but they will be compensated by shorter waiting times.Furthermore,in the internal firm,we also prove that this mechanism enables the decentralization of decisions,while maintaining centralized system-wide optimality.Numerical analysis shows that when there is sufficient capacity,the internal firm does not always need to set lower prices than the commercial firm in every period.

  8. Data Quality Objectives for Tank Farms Waste Compatibility Program

    Energy Technology Data Exchange (ETDEWEB)



    There are 177 waste storage tanks containing over 210,000 m{sup 3} (55 million gal) of mixed waste at the Hanford Site. The River Protection Project (RPP) has adopted the data quality objective (DQO) process used by the U.S. Environmental Protection Agency (EPA) (EPA 1994a) and implemented by RPP internal procedure (Banning 1999a) to identify the information and data needed to address safety issues. This DQO document is based on several documents that provide the technical basis for inputs and decision/action levels used to develop the decision rules that evaluate the transfer of wastes. A number of these documents are presently in the process of being revised. This document will need to be revised if there are changes to the technical criteria in these supporting documents. This DQO process supports various documents, such as sampling and analysis plans and double-shell tank (DST) waste analysis plans. This document identifies the type, quality, and quantity of data needed to determine whether transfer of supernatant can be performed safely. The requirements in this document are designed to prevent the mixing of incompatible waste as defined in Washington Administrative Code (WAC) 173-303-040. Waste transfers which meet the requirements contained in this document and the Double-Shell Tank Waste Analysis Plan (Mulkey 1998) are considered to be compatible, and prevent the mixing of incompatible waste.

  9. Lubricants for HFC-134a Compatible Rotary Compressors (United States)

    Takaichi, Kenji; Sakai, Hisakazu

    In replacing CFC-12 with HFC-134a for refrigerator compressors, the compatibility with lubricating oil, and lubrication in general, are of major concern. HFC-134a dose not have adequate solubility with current lubricating oils because of its molecular structure. Current oils also do not provide enough lubricating action when using HFC-134a. A new oil and new materials have to be utilized in order to use HFC-134a. Developing a new lubricating oil involved numerous tests of different combinations of many polyolester synthetic oils and additives. One of the pre-evaluated methods was pursued via sealed tube tests. Lubricated parts were selected by studies involving a plane-on-roller type of wear test machine and by analyzing the traces of acid material commonly created during the lubricating action. The matrices of new lubricating oils and new lubricated materials were estimated based on durability tests conducted on compressors and refrigerators. Results showed that polyolester synthetic oils having a low total acid value and including certain quantities of additives did not break down into a tar-like substance and they did not produce composite particles in the operating compressors and refrigerators. The study also found that ceramics and anti-corrosion alloy steel possessed good adrasion-reducing qualities. Based on our evaluation, we will implement compressor reliability tests and apply HFC-134a to rotary compressors for refrigerators.

  10. DNA Compatible Multistep Synthesis and Applications to DNA Encoded Libraries. (United States)

    Satz, Alexander Lee; Cai, Jianping; Chen, Yi; Goodnow, Robert; Gruber, Felix; Kowalczyk, Agnieszka; Petersen, Ann; Naderi-Oboodi, Goli; Orzechowski, Lucja; Strebel, Quentin


    Complex mixtures of DNA encoded small molecules may be readily interrogated via high-throughput sequencing. These DNA encoded libraries (DELs) are commonly used to discover molecules that interact with pharmaceutically relevant proteins. The chemical diversity displayed by the library is key to successful discovery of potent, novel, and drug-like chemical matter. The small molecule moieties of DELs are generally synthesized though a multistep process, and each chemical step is accomplished while it is simultaneously attached to an encoding DNA oligomer. Hence, library chemical diversity is often limited to DNA compatible synthetic reactions. Herein, protocols for 24 reactions are provided that have been optimized for high-throughput production of DELs. These protocols detail the multistep synthesis of benzimidazoles, imidazolidinones, quinazolinones, isoindolinones, thiazoles, and imidazopyridines. Additionally, protocols are provided for a diverse range of useful chemical reactions including BOC deprotection (under pH neutral conditions), carbamylation, and Sonogashira coupling. Last, step-by-step protocols for synthesizing functionalized DELs from trichloronitropyrimidine and trichloropyrimidine scaffolds are detailed.

  11. Electromagnetic compatibility of implantable neurostimulators to RFID emitters

    Directory of Open Access Journals (Sweden)

    Guag Joshua W


    Full Text Available Abstract Background The objective of this study is to investigate electromagnetic compatibility (EMC of implantable neurostimulators with the emissions from radio frequency identification (RFID emitters. Methods Six active implantable neurostimulators with lead systems were tested for susceptibility to electromagnetic fields generated by 22 RFID emitters. These medical devices have been approved for marketing in the U.S. for a number of intended uses that include: epilepsy, depression, incontinence, Parkinsonian tremor and pain relief. Each RFID emitter had one of the following carrier frequencies: 125 kHz, 134 kHz, 13.56 MHz, 433 MHz, 915 MHz and 2.45 GHz Results The test results showed the output of one of the implantable neurostimulators was inhibited by 134 kHz RFID emitter at separation distances of 10 cm or less. The output of the same implantable neurostimulator was also inhibited by another 134 kHz RFID emitter at separation distances of 10 cm or less and also showed inconsistent pulsing rate at a separation distance of 15 cm. Both effects occurred during and lasted through out the duration of the exposure. Conclusions The clinical significance of the effects was assessed by a clinician at the U.S. Food and Drug Administration. The effects were determined to be clinically significant only if they occurred for extended period of time. There were no observed effects from the other 5 implantable neurostimulators or during exposures from other RFID emitters.

  12. Compatibility of a Diffractive Pupil and Coronagraphic Imaging (United States)

    Bendek, Eduardo; Belikov, Rusian; Pluzhnyk, Yevgeniy; Guyon, Olivier


    Detection and characterization of exo-earths require direct-imaging techniques that can deliver contrast ratios of 10(exp 10) at 100 milliarc-seconds or smaller angular separation. At the same time, astrometric data is required to measure planet masses and can help detect planets and constrain their orbital parameters. To minimize costs, a single space mission can be designed using a high efficiency coronograph to perform direct imaging and a diffractive pupil to calibrate wide-field distortions to enable high precision astrometric measurements. This paper reports the testing of a diffractive pupil on the high-contrast test bed at the NASA Ames Research Center to assess the compatibility of using a diffractive pupil with coronographic imaging systems. No diffractive contamination was found within our detectability limit of 2x10(exp -7) contrast outside a region of 12lambda/D and 2.5x10(exp -6) within a region spanning from 2 to 12lambda/D. Morphology of the image features suggests that no contamination exists even beyond the detectability limit specified or at smaller working angles. In the case that diffractive contamination is found beyond these stated levels, active wavefront control would be able to mitigate its intensity to 10(exp -7) or better contrast.

  13. Shuttle Communications and Tracking, Avionics, and Electromagnetic Compatibility (United States)

    deSilva, K.; Hwu, Shian; Kindt, Kaylene; Kroll, Quin; Nuss, Ray; Romero, Denise; Schuler, Diana; Sham, Catherine; Scully, Robert


    By definition, electromagnetic compatibility (EMC) is the capability of components, sub-systems, and systems, to operate in their intended electromagnetic environment, within an established margin of safety, and at design levels of performance. Practice of the discipline itself incorporates knowledge of various aspects of applied physics, materials science, and engineering across the board, and includes control and mitigation of undesirable electromagnetic interaction between intentional and unintentional emitters and receivers of radio frequency energy, both within and external to the vehicle; identification and control of the hazards of non-ionizing electromagnetic radiation to personnel, ordnance, and fuels and propellants; and vehicle and system protection from the direct and indirect effects of lightning and various other forms of electrostatic discharge (ESD) threats, such as triboelectrification and plasma charging. EMC is extremely complex and far-reaching, affecting in some degree every aspect of the vehicle s design and operation. The most successful efforts incorporate EMC design features and techniques throughout design and fabrication of the vehicle s structure and components, as well as appropriate operational considerations with regard to electromagnetic threats in the operational environment, from the beginning of the design effort to the end of the life cycle of the manufactured product. This approach yields the highest design performance with the lowest cost and schedule impact.

  14. About the Compatibility of DORIS and VLBI Observations (United States)

    Il'in, Gennady; Smolentsev, Sergey; Sergeev, Roman


    We investigated the compatibility of the DORIS and VLBI observations at Badary Observatory. The DORIS beacon stands at 100-m distance from the main radio telescope dish and transmits signals on two frequencies: 2036.25 MHz and 401.25 MHz. The latter frequency is modulated to send messages containing an ID number, timing information, data from the meteorological sensors, and engineering data (e.g., power). Both frequencies affect the S/X band radio telescope receivers. The parameters of the DORIS signals were measured at the outputs of the S/X band intermediate frequency amplifier. It was found that: (1) The level of RFI, produced by the DORIS beacon, practically corresponds to the level of the system (antenna plus receiver) noise signal and does not overload the S/X band receivers. (2) The DORIS 401.25 MHz signal is out of the frequency bands recorded during standard VLBI sessions. As a result, RFI from DORIS does not affect VLBI observations. This conclusion was confirmed after data correlations of actual VLBI observations that were conducted with the DORIS beacon turned on/off.

  15. Texture synthesis via the matching compatibility between patches

    Institute of Scientific and Technical Information of China (English)

    WANG WenCheng; LIU FeiTong; HUANG PeiJie; WU EnHua


    A new patch-based texture synthesis method is presented in this paper.By the method,a set of patches that can be matched with a sampled patch for growing textures effectively,called the matching compatibility between patches,is generated first for each patch,and the set is further optimized by culling the patches that may cause synthesis conflicts.In this way,similarity measurement calculation for selecting suitable patches in texture synthesis can be greatly saved,and synthesis conflicts between neighbouring patches are substantially reduced.Furthermore,retrace computation is Integrated in the synthesis process to improve the texture quality.As a result,the new method can produce high quality textures as texture optimization,the best method to date for producing good textures,and run in a time complexity linear to the size of the output texture.Experimental results show that the new method can interactively generate a large texture in 1024 × 1024 pixels,which is very difficult to achieve by existing methods.

  16. MRI-Compatible Pneumatic Robot for Transperineal Prostate Needle Placement. (United States)

    Fischer, Gregory S; Iordachita, Iulian; Csoma, Csaba; Tokuda, Junichi; Dimaio, Simon P; Tempany, Clare M; Hata, Nobuhiko; Fichtinger, Gabor


    Magnetic resonance imaging (MRI) can provide high-quality 3-D visualization of prostate and surrounding tissue, thus granting potential to be a superior medical imaging modality for guiding and monitoring prostatic interventions. However, the benefits cannot be readily harnessed for interventional procedures due to difficulties that surround the use of high-field (1.5T or greater) MRI. The inability to use conventional mechatronics and the confined physical space makes it extremely challenging to access the patient. We have designed a robotic assistant system that overcomes these difficulties and promises safe and reliable intraprostatic needle placement inside closed high-field MRI scanners. MRI compatibility of the robot has been evaluated under 3T MRI using standard prostate imaging sequences and average SNR loss is limited to 5%. Needle alignment accuracy of the robot under servo pneumatic control is better than 0.94 mm rms per axis. The complete system workflow has been evaluated in phantom studies with accurate visualization and targeting of five out of five 1 cm targets. The paper explains the robot mechanism and controller design, the system integration, and presents results of preliminary evaluation of the system.

  17. Compatibility of ITER candidate structural materials with static gallium

    Energy Technology Data Exchange (ETDEWEB)

    Luebbers, P.R.; Michaud, W.F.; Chopra, O.K.


    Tests were conducted on the compatibility of gallium with candidate structural materials for the International Thermonuclear Experimental Reactor, e.g., Type 316 SS, Inconel 625, and Nb-5 Mo-1 Zr alloy, as well as Armco iron, Nickel 270, and pure chromium. Type 316 stainless steel is least resistant to corrosion in static gallium and Nb-5 Mo-1 Zr alloy is most resistant. At 400{degrees}C, corrosion rates are {approx}4.0, 0.5, and 0.03 mm/yr for type 316 SS, Inconel 625, and Nb-5 Mo- 1 Zr alloy, respectively. The pure metals react rapidly with gallium. In contrast to findings in earlier studies, pure iron shows greater corrosion than nickel. The corrosion rates at 400{degrees}C are {ge}88 and 18 mm/yr, respectively, for Armco iron and Nickel 270. The results indicate that at temperatures up to 400{degrees}C, corrosion occurs primarily by dissolution and is accompanied by formation of metal/gallium intermetallic compounds. The solubility data for pure metals and oxygen in gallium are reviewed. The physical, chemical, and radioactive properties of gallium are also presented. The supply and availability of gallium, as well as price predictions through the year 2020, are summarized.

  18. Compatibility of gas turbine materials with steam cooling

    Energy Technology Data Exchange (ETDEWEB)

    Desai, V.; Tamboli, D.; Patel, Y. [Univ. of Central Florida, Orlando, FL (United States)


    Gas turbines had been traditionally used for peak load plants and remote locations as they offer advantage of low installation costs and quick start up time. Their use as a base load generator had not been feasible owing to their poor efficiency. However, with the advent of gas turbines based combined cycle plants (CCPs), continued advances in efficiency are being made. Coupled with ultra low NO{sub x} emissions, coal compatibility and higher unit output, gas turbines are now competing with conventional power plants for base load power generation. Currently, the turbines are designed with TIT of 2300{degrees}F and metal temperatures are maintained around 1700{degrees}F by using air cooling. New higher efficiency ATS turbines will have TIT as high as 2700{degrees}F. To withstand this high temperature improved materials, coatings, and advances in cooling system and design are warranted. Development of advanced materials with better capabilities specifically for land base applications are time consuming and may not be available by ATS time frame or may prove costly for the first generation ATS gas turbines. Therefore improvement in the cooling system of hot components, which can take place in a relatively shorter time frame, is important. One way to improve cooling efficiency is to use better cooling agent. Steam as an alternate cooling agent offers attractive advantages because of its higher specific heat (almost twice that of air) and lower viscosity.

  19. Biosphere Compatibility as a Principle of Sustainable Urban Development

    Directory of Open Access Journals (Sweden)

    Ivanova Zinaida


    Full Text Available The article covers safety and environmental issues, as well as the sustainable interaction between man and nature in the context of present-day cities. An important task, according to the authors, is the study of scientific approaches and practical achievements in this field, and then the detection of the most urgent critical issues. The coauthors provide an overview of numerous research projects on the treatment of nature, the anthropogenic load, the biosphere as a geological body, the noosphere, and ratios characterizing the condition of the biosphere. The coauthors believe that ecological management, aimed to reverse the treatment of nature, must be integrative. New legislation, effective control of its execution, new disciplines to be introduced at the level of secondary, vocational, and higher education, development of ecological schools of thought and advanced green standards and materials applicable to any construction operations may comprise an effective solution. The authors offer their vision of the challenges and outline the primary steps, including immediate implementation of urban planning solutions to be developed in accordance with the biosphere compatibility principles, with calculations of humanitarian balances of the bio-technosphere. The coauthors also consider the innovative approaches to the use of eco-friendly materials in construction projects.

  20. Electromagnetic compatibility. General presentation; Comptabilite electromagnetique. Presentation generale

    Energy Technology Data Exchange (ETDEWEB)

    Champiot, G.G. [Electricite de France (EDF), 75 - Paris (France)


    The electromagnetic environment has become an important parameter to take into account in any industrial project involving electronic systems. Four factors can conjugate to increase the problems of electromagnetic disturbances: the instrumentation and control systems which use very low voltage electronic components, the development of fast high-power electronic switching systems (thyristors etc..), the more and more frequent association of disturbing apparatuses and sensible equipments in the same integrated devices, and the sensitiveness of data processing systems. This introductory paper aims at building a general philosophy for the mastery of these phenomena: 1 - the aim of electromagnetic compatibility: notion, analysis, reduction of the problem to essentials; 2 - sources of electromagnetic disturbances: lightning, aurora borealis, disturbances due to intentional emissions (radiofrequency radiation, conduction), disturbances due to non-intentional emissions (thermal noise, switching of inductive currents, arc welding, start-up of vehicles with internal combustion engines, power lines, driving systems, fluorescent lamps, voltage drops and short cuts, harmonics, voltage transients), electrostatic discharges, nuclear electromagnetic pulses. (J.S.)