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Sample records for agilent expression chip

  1. Evaluating annotations of an Agilent expression chip suggests that many features cannot be interpreted

    Directory of Open Access Journals (Sweden)

    Ried Thomas

    2009-11-01

    Full Text Available Abstract Background While attempting to reanalyze published data from Agilent 4 × 44 human expression chips, we found that some of the 60-mer olignucleotide features could not be interpreted as representing single human genes. For example, some of the oligonucleotides align with the transcripts of more than one gene. We decided to check the annotations for all autosomes and the X chromosome systematically using bioinformatics methods. Results Out of 42683 reporters, we found that 25505 (60% passed all our tests and are considered "fully valid". 9964 (23% reporters did not have a meaningful identifier, mapped to the wrong chromosome, or did not pass basic alignment tests preventing us from correlating the expression values of these reporters with a unique annotated human gene. The remaining 7214 (17% reporters could be associated with either a unique gene or a unique intergenic location, but could not be mapped to a transcript in RefSeq. The 7214 reporters are further partitioned into three different levels of validity. Conclusion Expression array studies should evaluate the annotations of reporters and remove those reporters that have suspect annotations. This evaluation can be done systematically and semi-automatically, but one must recognize that data sources are frequently updated leading to slightly changing validation results over time.

  2. The characterization of four gene expression analysis in circulating tumor cells made by Multiplex-PCR from the AdnaTest kit on the lab-on-a-chip Agilent DNA 1000 platform

    Science.gov (United States)

    Škereňová, Markéta; Mikulová, Veronika; Čapoun, Otakar; Zima, Tomáš

    2016-01-01

    Introduction Nowadays, on-a-chip capillary electrophoresis is a routine method for the detection of PCR fragments. The Agilent 2100 Bioanalyzer was one of the first commercial devices in this field. Our project was designed to study the characteristics of Agilent DNA 1000 kit in PCR fragment analysis as a part of circulating tumour cell (CTC) detection technique. Despite the common use of this kit a complex analysis of the results from a long-term project is still missing. Materials and methods A commercially available Agilent DNA 1000 kit was used as a final step in the CTC detection (AdnaTest) for the determination of the presence of PCR fragments generated by Multiplex PCR. Data from 30 prostate cancer patients obtained during two years of research were analyzed to determine the trueness and precision of the PCR fragment size determination. Additional experiments were performed to demonstrate the precision (repeatability, reproducibility) and robustness of PCR fragment concentration determination. Results The trueness and precision of the size determination was below 3% and 2% respectively. The repeatability of the concentration determination was below 15%. The difference in concentration determination increases when Multiplex-PCR/storage step is added between the two measurements of one sample. Conclusions The characteristics established in our study are in concordance with the manufacturer’s specifications established for a ladder as a sample. However, the concentration determination may vary depending on chip preparation, sample storage and concentration. The 15% variation of concentration determination repeatability was shown to be partly proportional and can be suppressed by proper normalization. PMID:26981024

  3. RisaAligner software for aligning fluorescence data between Agilent 2100 Bioanalyzer chips: Application to soil microbial community analysis.

    Science.gov (United States)

    Navarro, Elisabeth; Fabrègue, Olivier; Scorretti, Riccardo; Reboulet, Jérémy; Simonet, Pascal; Dawson, Lorna; Demanèche, Sandrine

    2015-12-01

    Ribosomal Intergenic Spacer Analysis (RISA) is a high-resolution and highly reproducible fingerprinting technique for discriminating between microbial communities. The community profiles can be visualized using the Agilent 2100 Bioanalyzer. Comparison between fingerprints relies upon precise estimation of all amplified DNA fragment lengths; however, size standard computation can vary between gel runs. For complex samples such as soil microbial communities, discrimination by fragment size is not always sufficient. In such cases, the comparison of whole fluorescence data as a function of time (electrophoregrams) is more appropriate. When electrophoregrams [fluorescence = f (time)] are used, and more than one chip is involved, electrophoregram comparisons are challenging due to experimental variations between chips and the lack of correction by the Agilent software in such situations. Here we present RisaAligner software for analyzing and comparing electrophoregrams from Agilent chips using a nonlinear ladder-alignment algorithm. We demonstrate the robustness and substantial improvement of data analysis by analyzing soil microbial profiles obtained with Agilent DNA 1000 and High Sensitivity chips.

  4. Expression and significance of CHIP in canine mammary gland tumors.

    Science.gov (United States)

    Wang, Huanan; Yang, Xu; Jin, Yipeng; Pei, Shimin; Zhang, Di; Ma, Wen; Huang, Jian; Qiu, Hengbin; Zhang, Xinke; Jiang, Qiuyue; Sun, Weidong; Zhang, Hong; Lin, Degui

    2015-11-01

    CHIP (Carboxy terminus of Hsc70 Interacting Protein) is an E3 ubiquitin ligase that can induce ubiquitination and degradation of several oncogenic proteins. The expression of CHIP is frequently lower in human breast cancer than in normal breast tissue. However, the expression and role of CHIP in the canine mammary gland tumor (CMGT) remain unclear. We investigated the potential correlation between CHIP expression and mammary gland tumor prognosis in female dogs. CHIP expression was measured in 54 dogs by immunohistochemistry and real-time RT-PCR. CHIP protein expression was significantly correlated with the histopathological diagnosis, outcome of disease and tumor classification. The transcriptional level of CHIP was significantly higher in normal tissues (P=0.001) and benign tumors (P=0.009) than it in malignant tumors. CHIP protein expression was significantly correlated with the transcriptional level of CHIP (P=0.0102). The log-rank test survival curves indicated that patients with low expression of CHIP had shorter overall periods of survival than those with higher CHIP protein expression (P=0.050). Our data suggest that CHIP may play an important role in the formation and development of CMGTs and serve as a valuable prognostic marker and potential target for genetic therapy.

  5. Positioning Agility

    Science.gov (United States)

    Oza, Nilay; Abrahamsson, Pekka; Conboy, Kieran

    Agile methods are increasingly adopted by European companies. Academics too are conducting numerous studies on different tenets of agile methods. Companies often feel proud in marketing themselves as ‘agile’. However, the true notion of ‘being agile’ seems to have been overlooked due to lack of positioning of oneself for agility. This raises a call for more research and interactions between academia and the industry. The proposed workshop refers to this call. It will be highly relevant to participants, interested in positioning their company’s agility from organizational, group or project perspectives. The positioning of agility will help companies to better align their agile practices with stakeholder values. Results of the workshop will be shared across participants and they will also have opportunity to continue their work on agile positioning in their companies. At broader level, the work done in this workshop will contribute towards developing Agile Positioning System.

  6. Express Lane Eligibility for Medicaid and CHIP Coverage

    Data.gov (United States)

    U.S. Department of Health & Human Services — States may rely on eligibility information from "Express Lane" agency programs to streamline and simplify enrollment and renewal in Medicaid and CHIP. Express Lane...

  7. "Hook"-calibration of GeneChip-microarrays: Chip characteristics and expression measures

    Directory of Open Access Journals (Sweden)

    Krohn Knut

    2008-08-01

    Full Text Available Abstract Background Microarray experiments rely on several critical steps that may introduce biases and uncertainty in downstream analyses. These steps include mRNA sample extraction, amplification and labelling, hybridization, and scanning causing chip-specific systematic variations on the raw intensity level. Also the chosen array-type and the up-to-dateness of the genomic information probed on the chip affect the quality of the expression measures. In the accompanying publication we presented theory and algorithm of the so-called hook method which aims at correcting expression data for systematic biases using a series of new chip characteristics. Results In this publication we summarize the essential chip characteristics provided by this method, analyze special benchmark experiments to estimate transcript related expression measures and illustrate the potency of the method to detect and to quantify the quality of a particular hybridization. It is shown that our single-chip approach provides expression measures responding linearly on changes of the transcript concentration over three orders of magnitude. In addition, the method calculates a detection call judging the relation between the signal and the detection limit of the particular measurement. The performance of the method in the context of different chip generations and probe set assignments is illustrated. The hook method characterizes the RNA-quality in terms of the 3'/5'-amplification bias and the sample-specific calling rate. We show that the proper judgement of these effects requires the disentanglement of non-specific and specific hybridization which, otherwise, can lead to misinterpretations of expression changes. The consequences of modifying probe/target interactions by either changing the labelling protocol or by substituting RNA by DNA targets are demonstrated. Conclusion The single-chip based hook-method provides accurate expression estimates and chip-summary characteristics

  8. A newly designed 45 to 60 mer oligonucleotide Agilent platform microarray for global gene expression studies of Synechocystis PCC6803: example salt stress experiment

    NARCIS (Netherlands)

    Aguirre von Wobeser, E.; Huisman, J.; Ibelings, B.; Matthijs, H.C.P.; Matthijs, H.C.P.

    2005-01-01

    A newly designed 45 to 60 mer oligonucleotide Agilent platform microarray for global gene expression studies of Synechocystis PCC6803: example salt stress experiment Eneas Aguirre-von-Wobeser 1, Jef Huisman1, Bas Ibelings2 and Hans C.P. Matthijs1 1 Universiteit van Amsterdam, Amsterdam, The Netherla

  9. Agile Mythbusting

    Science.gov (United States)

    2015-01-01

    approaches when we find them Adding in a little humor along the way… 81 Agile Myths, Picatinny Arsenal Lapham, Wrubel Jan 2015 © 2015 Carnegie Mellon...stakeholders? Where are the political “bodies” buried? How do the “ghosts” in the stakeholder map affect what people do today? Value stream mapping, a lean

  10. Agile attitude

    DEFF Research Database (Denmark)

    Ovesen, Nis; Eriksen, Kaare; Tollestrup, Christian

    2011-01-01

    Motivated by the growing number of hybrid products with extensive software and service components, this paper reviews four representative agile methods from the domain of software for their applicability to both the industrial design education and practice. The review is based on a comparative an...

  11. Agile Contracts

    DEFF Research Database (Denmark)

    Pries-Heje, Jan; Pries-Heje, Lene

    2014-01-01

    with “endless” re-negotiation of the requirements; you need a more flexible way to develop IS. A new way of coping with many changes is to use an agile development approach and a fixed budget and resources contract. This paper presents an example case. We analyse the case and design a guideline for how...... to implement a fixed budget and resources contract in the public sector. The guideline includes elements to cope with challenges in a tender process such as transparency, criteria for supplier selection, and live assessment of resource skills and capabilities, as well as achieving the flexibility for change...

  12. Microfluidic chips for protein differential expression profiling.

    Science.gov (United States)

    Armenta, Jenny M; Dawoud, Abdulilah A; Lazar, Iulia M

    2009-04-01

    Biomarker discovery and screening using novel proteomic technologies is an area that is attracting increased attention in the biomedical community. Early detection of abnormal physiological conditions will be highly beneficial for diagnosing various diseases and increasing survivability rates. Clearly, progress in this area will depend on the development of fast, reliable, and highly sensitive and specific sample bioanalysis methods. Microfluidics has emerged as a technology that could become essential in proteomics research as it enables the integration of all sample preparation, separation, and detection steps, with the added benefit of enhanced sample throughput. The combination of these advantages with the sensitivity and capability of MS detection to deliver precise structural information makes microfluidics-MS a very competitive technology for biomarker discovery. The integration of LC microchip devices with MS detection, and specifically their applicability to biomarker screening applications in MCF-7 breast cancer cellular extracts is reported in this manuscript. Loading approximately 0.1-1 microg of crude protein extract tryptic digest on the chip has typically resulted in the reliable identification of approximately 40-100 proteins. The potential of an LC-ESI-MS chip for comparative proteomic analysis of isotopically labeled MCF-7 breast cancer cell extracts is explored for the first time.

  13. Nonspecific hybridization scaling of microarray expression estimates: a physicochemical approach for chip-to-chip normalization.

    Science.gov (United States)

    Binder, Hans; Brücker, Jan; Burden, Conrad J

    2009-03-05

    The problem of inferring accurate quantitative estimates of transcript abundances from gene expression microarray data is addressed. Particular attention is paid to correcting chip-to-chip variations arising mainly as a result of unwanted nonspecific background hybridization to give transcript abundances measured in a common scale. This study verifies and generalizes a model of the mutual dependence between nonspecific background hybridization and the sensitivity of the specific signal using an approach based on the physical chemistry of surface hybridization. We have analyzed GeneChip oligonucleotide microarray data taken from a set of five benchmark experiments including dilution, Latin Square, and "Golden spike" designs. Our analysis concentrates on the important effect of changes in the unwanted nonspecific background inherent in the technology due to changes in total RNA target concentration and/or composition. We find that incremental changes in nonspecific background entail opposite sign incremental changes in the effective specific binding constant. This effect, which we refer to as the "up-down" effect, results from the subtle interplay of competing interactions between the probes and specific and nonspecific targets at the chip surface and in bulk solution. We propose special rules for proper normalization of expression values considering the specifics of the up-down effect. Particularly for normalization one has to level the expression values of invariant expressed probes. Existing heuristic normalization techniques which do not exclude absent probes, level intensities instead of expression values, and/or use low variance criteria for identifying invariant sets of probes lead to biased results. Strengths and pitfalls of selected normalization methods are discussed. We also find that the extent of the up-down effect is modified if RNA targets are replaced by DNA targets, in that microarray sensitivity and specificity are improved via a decrease in

  14. AGILE Data Center and AGILE science highlights

    Energy Technology Data Exchange (ETDEWEB)

    Pittori, C. [ASI Science Data Center, ESRIN, I-00044 Frascati (RM) (Italy); INAF-OAR, Via Frascati 33, I00040 Monte Porzio Catone (RM) (Italy)

    2013-06-15

    AGILE is a scientific mission of the Italian Space Agency (ASI) with INFN, INAF e CIFS participation, devoted to gamma-ray astrophysics. The satellite is in orbit since April 23rd, 2007. Gamma-ray astrophysics above 100 MeV is an exciting field of astronomical sciences that has received a strong impulse in recent years. Despite the small size and budget, AGILE produced several important scientific results, among which the unexpected discovery of strong and rapid gamma-ray flares from the Crab Nebula. This discovery won to the AGILE PI and the AGILE Team the prestigious Bruno Rossi Prize for 2012, an international recognition in the field of high energy astrophysics. We present here the AGILE data center main activities, and we give an overview of the AGILE scientific highlights after 5 years of operations.

  15. Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data

    Directory of Open Access Journals (Sweden)

    Augood Sarah J

    2006-04-01

    Full Text Available Abstract Background Gene expression microarray experiments are expensive to conduct and guidelines for acceptable quality control at intermediate steps before and after the samples are hybridised to chips are vague. We conducted an experiment hybridising RNA from human brain to 117 U133A Affymetrix GeneChips and used these data to explore the relationship between 4 pre-chip variables and 22 post-chip outcomes and quality control measures. Results We found that the pre-chip variables were significantly correlated with each other but that this correlation was strongest between measures of RNA quality and cRNA yield. Post-mortem interval was negatively correlated with these variables. Four principal components, reflecting array outliers, array adjustment, hybridisation noise and RNA integrity, explain about 75% of the total post-chip measure variability. Two significant canonical correlations existed between the pre-chip and post-chip variables, derived from MAS 5.0, dChip and the Bioconductor packages affy and affyPLM. The strongest (CANCOR 0.838, p Conclusion We have found that the post-chip variables having the strongest association with quantities measurable before hybridisation are those reflecting RNA integrity. Other aspects of quality, such as noise measures (reflecting the execution of the assay or measures reflecting data quality (outlier status and array adjustment variables are not well predicted by the variables we were able to determine ahead of time. There could be other variables measurable pre-hybridisation which may be better associated with expression data quality measures. Uncovering such connections could create savings on costly microarray experiments by eliminating poor samples before hybridisation.

  16. Agile software development

    CERN Document Server

    Stober, Thomas

    2009-01-01

    Software Development is moving towards a more agile and more flexible approach. It turns out that the traditional 'waterfall' model is not supportive in an environment where technical, financial and strategic constraints are changing almost every day. But what is agility? What are today's major approaches? And especially: What is the impact of agile development principles on the development teams, on project management and on software architects? How can large enterprises become more agile and improve their business processes, which have been existing since many, many years? What are the limit

  17. Agile risk management

    CERN Document Server

    Moran, Alan

    2014-01-01

    This work is the definitive guide for IT managers and agile practitioners. It elucidates the principles of agile risk management and how these relate to individual projects. Explained in clear and concise terms, this synthesis of project risk management and agile techniques is illustrated using the major methodologies such as XP, Scrum and DSDM.Although the agile community frequently cites risk management, research suggests that risk is often narrowly defined and, at best, implicitly treated, which in turn leads to an inability to make informed decisions concerning risk and reward and a poor u

  18. C2 Agility

    DEFF Research Database (Denmark)

    Mitchell, Dr. William; Alberts, David S.; Bernier, Francois

    Agility is the capability to successfully effect, cope with, and/or exploit changes in circumstances. While other factors will also influence outcomes, C2 Agility enables entities to effectively and efficiently employ the resources they have in a timely manner in a variety of missions and circums......Agility is the capability to successfully effect, cope with, and/or exploit changes in circumstances. While other factors will also influence outcomes, C2 Agility enables entities to effectively and efficiently employ the resources they have in a timely manner in a variety of missions...... and circumstances. SAS-085 was formed to improve the understanding of C2 Agility and assess its importance to NATO. SAS-085 accomplished these objectives by articulating the principles of C2 Agility, in the form of a C2 Agility Conceptual Model, substantially validating this model and establishing the importance...... of improving C2 Agility with empirical evidence obtained from a set of retrospective case studies and simulation-based experiments. Further, it identified next steps toward practical implementation in NATO operations and priorities for increasing the rigor and practicality of methods for measuring...

  19. Patterns for agility

    NARCIS (Netherlands)

    Iacob, M.E.; Lankhorst, M.M.; Schrier, A.; Lankhorst, M.

    2012-01-01

    The use of patterns is an important practice in the agile software development community. There are many sources for patterns. In this chapter, we will examine several pattern collections and explore their potential contribution to system agility. We illustrate our pattern approach by a detailed exa

  20. Agile Software Development

    Science.gov (United States)

    Biju, Soly Mathew

    2008-01-01

    Many software development firms are now adopting the agile software development method. This method involves the customer at every level of software development, thus reducing the impact of change in the requirement at a later stage. In this article, the principles of the agile method for software development are explored and there is a focus on…

  1. Agile project management. A case study on agile practices

    OpenAIRE

    Henriksen, André

    2016-01-01

    In project management and particularly software project management, there has been a shift from traditional plan based project management to the agile event driven project management style. Agile project management has for some time been viewed as the new big change that will revolutionize the software industry. The concept of agile has been around for some time, and although knowledge and usage are increasing, agile is not always the answer. Understanding when to use agile and which succ...

  2. Agile distributed software development

    DEFF Research Database (Denmark)

    Persson, John Stouby; Mathiassen, Lars; Aaen, Ivan

    2012-01-01

    While face-to-face interaction is fundamental in agile software development, distributed environments must rely extensively on mediated interactions. Practicing agile principles in distributed environments therefore poses particular control challenges related to balancing fixed vs. evolving quality...... requirements and people vs. process-based collaboration. To investigate these challenges, we conducted an in-depth case study of a successful agile distributed software project with participants from a Russian firm and a Danish firm. Applying Kirsch’s elements of control framework, we offer an analysis of how...

  3. Agility Into Victory

    DEFF Research Database (Denmark)

    Juhlin, Jonas Alastair

    This paper will investigate how the three core concepts of command and control agility can increase the chance for a successful outcome in military operations and what elements that should be strengthen within a military organization in order to achieve an agile approach to command and control. T....... This paper argues the concept was framed and tested during WWII in Burma and the Far East Asia campaign and that an agile approach to command and control is highly relevant for modern military organizations wishing to improve their warfighting capabilities....

  4. Detection of gene expression pattern in the early stage after spinal cord injury by gene chip

    Institute of Scientific and Technical Information of China (English)

    刘成龙; 靳安民; 童斌辉

    2003-01-01

    Objective: To study the changes of the gene expression pattern of spinal cord tissues in the early stage after injury by DNA microarray (gene chip). Methods: The contusion model of rat spinal cord was established according to Allen's falling strike method and the gene expression patterns of normal and injured spinal cord tissues were studied by gene chip. Results: The expression of 45 genes was significantly changed in the early stage after spinal cord injury, in which 22 genes up-regulated and 23 genes down-regulated. Conclusions: The expression of some genes changes significantly in the early stage after spinal cord injury, which indicates the complexity of secondary spinal cord injury.

  5. Agile IT Security Implementation Methodology

    CERN Document Server

    Laskowski, Jeff

    2011-01-01

    The book is a tutorial that goes from basic to professional level for Agile IT security. It begins by assuming little knowledge of agile security. Readers should hold a good knowledge of security methods and agile development. The book is targeted at IT security managers, directors, and architects. It is useful for anyone responsible for the deployment of IT security countermeasures. Security people with a strong knowledge of agile software development will find this book to be a good review of agile concepts.

  6. THE AGILE METHODOLOGY

    Directory of Open Access Journals (Sweden)

    Charul Deewan

    2012-09-01

    Full Text Available The technologies are numerous and Software is the one whichis most widely used. Some companies have their owncustomized methodology for developing their software but themajority speaks about two kinds of methodologies: Traditionaland Agile methodologies. In this paper, we will discuss someof the aspects of what Agile methodology is, how it can beused to get the best result from a project, how do we get it towork in an organization.

  7. Generalized Agile Estimation Method

    Directory of Open Access Journals (Sweden)

    Shilpa Bahlerao

    2011-01-01

    Full Text Available Agile cost estimation process always possesses research prospects due to lack of algorithmic approaches for estimating cost, size and duration. Existing algorithmic approach i.e. Constructive Agile Estimation Algorithm (CAEA is an iterative estimation method that incorporates various vital factors affecting the estimates of the project. This method has lots of advantages but at the same time has some limitations also. These limitations may due to some factors such as number of vital factors and uncertainty involved in agile projects etc. However, a generalized agile estimation may generate realistic estimates and eliminates the need of experts. In this paper, we have proposed iterative Generalized Estimation Method (GEM and presented algorithm based on it for agile with case studies. GEM  based algorithm various project domain classes and vital factors with prioritization level. Further, it incorporates uncertainty factor to quantify the risk of project for estimating cost, size and duration. It also provides flexibility to project managers for deciding on number of vital factors, uncertainty level and project domains thereby maintaining the agility.

  8. Gene expression profiling in chicken heterophils with Salmonella enteritidis stimulation using a chicken 44 K Agilent microarray

    Directory of Open Access Journals (Sweden)

    Li Xianyao

    2008-11-01

    Full Text Available Abstract Background Salmonella enterica serovar Enteritidis (SE is one of the most common food-borne pathogens that cause human salmonellosis and usually results from the consumption of contaminated poultry products. The mechanism of SE resistance in chickens remains largely unknown. Previously, heterophils isolated from broilers with different genetic backgrounds (SE-resistant [line A] and -susceptible [line B] have been shown to be important in defending against SE infections. To dissect the interplay between heterophils and SE infection, we utilized large-scale gene expression profiling. Results The results showed more differentially expressed genes were found between different lines than between infection (SE-treated and non-infection (control samples within line. However, the numbers of expressed immune-related genes between these two comparisons were dramatically different. More genes related to immune function were down-regulated in line B than line A. The analysis of the immune-related genes indicated that SE infection induced a stronger, up-regulated gene expression of line heterophils A than line B, and these genes include several components in the Toll-like receptor (TLR signaling pathway, and genes involved in T-helper cell activation. Conclusion We found: (1 A divergent expression pattern of immune-related genes between lines of different genetic backgrounds. The higher expression of immune-related genes might be more beneficial to enhance host immunity in the resistant line; (2 a similar TLR regulatory network might exist in both lines, where a possible MyD88-independent pathway may participate in the regulation of host innate immunity; (3 the genes exclusively differentially expressed in line A or line B with SE infection provided strong candidates for further investigating SE resistance and susceptibility. These findings have laid the foundation for future studies of TLR pathway regulation and cellular modulation of SE infection

  9. Agile anywhere essays on agile projects and beyond

    CERN Document Server

    Hazzan, Orit

    2014-01-01

    The message conveyed in this work is that agility can be implemented anywhere. Accordingly, ten guidelines are presented for the adoption of agility to enable us to cope with changes in our lives, in our teams, and in our organizations. Since the authors advocate agility, the content is presented in the form of concise standalone chapters, allowing the reader to focus on the specific topic they wish to adopt in order to become agile.

  10. Adopting to Agile Software Development

    Directory of Open Access Journals (Sweden)

    Linkevics Gusts

    2014-12-01

    Full Text Available Agile software development can be made successful, but there is no well-defined way how to achieve this. The problem is that the successful adoption of agile methods and practices is a complex process and this process should be customizable for a particular organization or a team. This research focuses on identification of agile methods and practices. Result of the research is the ranking of agile methods, practices and their usage trends. As some terms of agile software development are interpreted differently in different organizations and teams, terminology used is analyzed. Results of the research can be used as a reference material for those who are planning to adopt agile methods or are looking for the next agile practice to implement. Results will be used for the development of an expert system to support agile adoption.

  11. Agile Metrics: Progress Monitoring of Agile Contractors

    Science.gov (United States)

    2014-01-01

    3 4 5 6 7 8 Story Points Delivered by the Team Sprint Number Bar Chart of Velocity CMU/SEI-2013-TN-029 | 13 In this fictional case, the ‘back...counter to tenets of Agile methods. Velocity is a local measure, used by an individual development team to gauge the realism of commitments they make. The...is a metric primarily intended to guide the development team itself to understand the realism in delivery commitments. The feed- back provided at the

  12. Agile Methodology - Past and Future

    Science.gov (United States)

    2011-05-01

    Agile Methodology – P t d F t ”as an u ure Warren W. Tignor SAIC Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting...AND SUBTITLE Agile Methodology - Past and Future 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER...Takeuchi & Nonaka HBR 1986, p139 RUGBY Waterfall Red vs Agile Black Team- . - Manifesto 2001 SCRUM GRAPHIC* * Adapted from Schwaber (2007) Agile

  13. Software Development: Agile vs. Traditional

    Directory of Open Access Journals (Sweden)

    Marian STOICA

    2013-01-01

    Full Text Available Organizations face the need to adapt themselves to a complex business environment, in continuous change and transformation. Under these circumstances, organization agility is a key element in gaining strategic advantages and market success. Achieving and maintaining agility requires agile architectures, techniques, methods and tools, able to react in real time to change requirements. This paper proposes an incursion in the software development, from traditional to agile.

  14. The GENOTEND chip: a new tool to analyse gene expression in muscles of beef cattle for beef quality prediction

    Directory of Open Access Journals (Sweden)

    Hocquette Jean-Francois

    2012-08-01

    Full Text Available Abstract Background Previous research programmes have described muscle biochemical traits and gene expression levels associated with beef tenderness. One of our results concerning the DNAJA1 gene (an Hsp40 was patented. This study aims to confirm the relationships previously identified between two gene families (heat shock proteins and energy metabolism and beef quality. Results We developed an Agilent chip with specific probes for bovine muscular genes. More than 3000 genes involved in muscle biology or meat quality were selected from genetic, proteomic or transcriptomic studies, or from scientific publications. As far as possible, several probes were used for each gene (e.g. 17 probes for DNAJA1. RNA from Longissimus thoracis muscle samples was hybridised on the chips. Muscles samples were from four groups of Charolais cattle: two groups of young bulls and two groups of steers slaughtered in two different years. Principal component analysis, simple correlation of gene expression levels with tenderness scores, and then multiple regression analysis provided the means to detect the genes within two families (heat shock proteins and energy metabolism which were the most associated with beef tenderness. For the 25 Charolais young bulls slaughtered in year 1, expression levels of DNAJA1 and other genes of the HSP family were related to the initial or overall beef tenderness. Similarly, expression levels of genes involved in fat or energy metabolism were related with the initial or overall beef tenderness but in the year 1 and year 2 groups of young bulls only. Generally, the genes individually correlated with tenderness are not consistent across genders and years indicating the strong influence of rearing conditions on muscle characteristics related to beef quality. However, a group of HSP genes, which explained about 40% of the variability in tenderness in the group of 25 young bulls slaughtered in year 1 (considered as the reference group, was

  15. Agile software development

    CERN Document Server

    Dingsoyr, Torgeir; Moe, Nils Brede

    2010-01-01

    Agile software development has become an umbrella term for a number of changes in how software developers plan and coordinate their work, how they communicate with customers and external stakeholders, and how software development is organized in small, medium, and large companies, from the telecom and healthcare sectors to games and interactive media. Still, after a decade of research, agile software development is the source of continued debate due to its multifaceted nature and insufficient synthesis of research results. Dingsoyr, Dyba, and Moe now present a comprehensive snapshot of the kno

  16. Strategic agility for nursing leadership.

    Science.gov (United States)

    Shirey, Maria R

    2015-06-01

    This department highlights change management strategies that may be successful in strategically planning and executing organizational change. In this article, the author discusses strategic agility as an important leadership competency and offers approaches for incorporating strategic agility in healthcare systems. A strategic agility checklist and infrastructure-building approach are presented.

  17. Making Agile Work for You

    Science.gov (United States)

    2011-07-20

    Carnegie Mellon University Twitter #seiwebinar SCRUM Scrum is an iterative, incremental methodology for managing agile software projects. The Team...Extreme Programming (XP) • SCRUM • Dynamic Systems Development Method (DSDM) • Adaptive Software Development • Crystal • Feature-Driven Development...and Agile Methodologies Support Agile TSP Team organization Team organization Project management – planning and estimating Project management – planning

  18. An agile implementation of SCRUM

    Science.gov (United States)

    Gannon, Michele

    Is Agile a way to cut corners? To some, the use of an Agile Software Development Methodology has a negative connotation - “ Oh, you're just not producing any documentation” . So can a team with no experience in Agile successfully implement and use SCRUM?

  19. The agile edge managing projects effectively using agile scrum

    CERN Document Server

    Vanderjack, Brian

    2015-01-01

    This concise book is an effective source for understanding Agile Scrum development; why we use it and how it works. It will explain how work gets done in manageable iterations (sprints) and the team meetings that keep work on track (ceremonies). Also, since risk is a constant threat to any team-based project, managing risk in an Agile Scrum environment is specii cally discussed. This book is for: New Agile Scrum team members. Team leaders - this book describes the foundation of Agile Scrum, which can save time getting team members on the same page. Trainer/Educator of Agile Scrum - this boo

  20. Making Sense of Agile Project Management Balancing Control and Agility

    CERN Document Server

    Cobb, Charles G

    2011-01-01

    The book is intended to provide a much deeper understanding of agile principles, methodologies, and practices to enable project managers to develop a more agile approach and understand how to blend and tailor agile and traditional principles, methodologies, and practices to create an appropriate balance of control and agility to fit a business environment as well as the risks and complexities of any individual project.  The book will also provide business managers and leaders an understanding of how to fit agile methodologies into an overall business strategy that provides the right balan

  1. Improving Agile Software Practice

    DEFF Research Database (Denmark)

    Tjørnehøj, Gitte

    2006-01-01

    Software process improvement in small and agile organizations is often problematic, but achieving good SPI-assessments can still be necessary to stay in the marked or to meet demands of multinational owners. The traditional norm driven, centralized and control centered improvement approaches has...

  2. Creating IT agility.

    Science.gov (United States)

    Glaser, John

    2008-04-01

    Seven steps healthcare organizations can take to improve IT agility are: Pay attention to the capabilities of IT applications. Establish short project phases. Stage the release of capital and new IT positions. Cross-train IT staff. Adopt technology standards. Shorten IT plan time horizons. Align IT with organizational strategies and priorities.

  3. AGILE DATA CENTER AT ASDC AND AGILE HIGHLIGHTS

    Directory of Open Access Journals (Sweden)

    Carlotta Pittori

    2013-12-01

    Full Text Available We present an overview of the main AGILE Data Center activities and the AGILE scientific highlights during the first 5 years of operations. AGILE is an ASI space mission in joint collaboration with INAF, INFN and CIFS, dedicated to the observation of the gamma-ray Universe. The AGILE satellite was launched on April 23rd, 2007, and is devoted to gamma-ray astrophysics in the 30MeV ÷ 50 GeV energy range, with simultaneous X-ray imaging capability in the 18 ÷ 60 keV band. Despite the small size and budget, AGILE has produced several important scientific results, including the unexpected discovery of strong and rapid gamma-ray flares from the Crab Nebula over daily timescales. This discovery won AGILE PI and the AGILE Team the prestigious Bruno Rossi Prize for 2012, an international award in the field of high energy astrophysics. Thanks to its sky monitoring capability and fast ground segment alert system, AGILE is substantially improving our knowledge of the gamma-ray sky, also making a crucial contribution to the study of the terrestrial gamma-ray flashes (TGFs detected in the Earth atmosphere. The AGILE Data Center, part of the ASI Science Data Center (ASDC located in Frascati, Italy, is in charge of all the science oriented activities related to the analysis, archiving and distribution of AGILE data.

  4. CHIP buffers heterogeneous Bcl-2 expression levels to prevent augmentation of anticancer drug-resistant cell population.

    Science.gov (United States)

    Tsuchiya, M; Nakajima, Y; Waku, T; Hiyoshi, H; Morishita, T; Furumai, R; Hayashi, Y; Kishimoto, H; Kimura, K; Yanagisawa, J

    2015-08-27

    Many types of cancer display heterogeneity in various features, including gene expression and malignant potential. This heterogeneity is associated with drug resistance and cancer progression. Recent studies have shown that the expression of a major protein quality control ubiquitin ligase, carboxyl terminus of Hsc70-interacting protein (CHIP), is negatively correlated with breast cancer clinicopathological stages and poor overall survival. Here we show that CHIP acts as a capacitor of heterogeneous Bcl-2 expression levels and prevents an increase in the anticancer drug-resistant population in breast cancer cells. CHIP knockdown in breast cancer cells increased variation in Bcl-2 expression levels, an antiapoptotic protein, among the cells. Our results also showed that CHIP knockdown increased the proportion of anticancer drug-resistant cells. These findings suggest that CHIP buffers variation in gene expression levels, affecting resistance to anticancer drugs. In single-cell clones derived from breast cancer cell lines, CHIP knockdown did not alter the variation in Bcl-2 expression levels and the proportion of anticancer drug-resistant cells. In contrast, when clonal cells were treated with a mutagen, the variation in Bcl-2 expression levels and proportion of anticancer drug-resistant cells were altered by CHIP knockdown. These results suggest that CHIP masks genetic variations to suppress heterogeneous Bcl-2 expression levels and prevents augmentation of the anticancer drug-resistant population of breast cancer cells. Because genetic variation is a major driver of heterogeneity, our results suggest that the degree of heterogeneity in expression levels is decided by a balance between genetic variation and the buffering capacity of CHIP.

  5. Trust in agile teams

    DEFF Research Database (Denmark)

    Tjørnehøj, Gitte; Fransgård, Mette; Skalkam, Signe

    2012-01-01

    success. This article reports from a study of two agile DSD teams with very different organization and collaboration patterns. It addresses the role of trust and distrust in DSD by analyzing how the team members’ trust developed and erode through the lifetime of the two collaborations and how management...... actions influenced this. We see two important lessons from the analysis. First the agile practices of daily Scrum and self organizing team can empower DSD teams to manage their own development of trust and thereby alleviate the obstacles of DSD. Second if management fails to support the development......Abstract. Distributed software development (DSD) is becoming everyday practice in the software field. Difficult challenges and difficulty reaching the expected benefits are well documented. The key challenges are communication, coordination and control issues due to temporal, geographical and socio...

  6. Agile & Distributed Project Management

    DEFF Research Database (Denmark)

    Pries-Heje, Jan; Pries-Heje, Lene

    2011-01-01

    Scrum has gained surprising momentum as an agile IS project management approach. An obvious question is why Scrum is so useful? To answer that question we carried out a longitudinal study of a distributed project using Scrum. We analyzed the data using coding and categorisation and three carefull...... and coordination mechanisms by allowing both local and global articulation of work in the project. That is why Scrum is especially useful for distributed IS project management and teamwork....

  7. Difference of Gene Expression Profiles between Barrett's Esophagus and Cardia Intestinal Metaplasia by Gene Chip

    Institute of Scientific and Technical Information of China (English)

    CHANG Ying; LIU Bin

    2006-01-01

    The difference of gene expression profile changes in Barrettes esophagus (BE) and cardia intestinal metaplasia (CIM) epithelium was studied and the novel associated genes were screened in the early stage by cDNA microarray. The cDNA retro-transcribed from equal quantity mRNA from BE and CIM epithelial tissues were labeled with Cy3 and Cy5 fluorescence as probes. The mixed probe was hybridized with three pieces BiostarH-40s double dot human whole gene chip. The chips were scanned with a ScanArray 4000. The acquired images were analyzed using GenePix Pro 3.0 software. It was found a total of 141 genes were screened out that exhibited differentially expression more than 2 times in all three chips. It was identified that in gene expression profiles of BE, 74 genes were up-regulated and 67 down-regulated as compared with CIM. The comparison between the difference of gene expression profile changes in BE and CIM epithelia revealed that there existed the difference between BE and CIM at gene level. 141 genes with the expression more than two time were probably related to the occurrence and development of BE and the promotion or progress in adenocarcinoma.

  8. AGILE and blazar studies

    CERN Document Server

    Marisaldi, M; Vercellone, S; Donnarumma, I; Bulgarelli, A; Chen, A W; Giuliani, A; Longo, F; Pacciani, L; Pucella, G; Tavani, M; Vittorini, V

    2009-01-01

    During the first two years of observation, AGILE detected several blazars at high significance: 3C 279, 3C 454.3, PKS 1510-089, S5 0716+714, 3C 273, W Comae, Mrk 421 and PKS 0537-441. We obtained long-term coverage of 3C 454.3, for a total of more than three months at energies above 100 MeV. 3C 273 was the first blazar detected simultaneously by the AGILE gamma-ray detector and by its hard X-ray monitor. S5 0716+714, an intermediate BL Lac object, exhibited a very fast and intense gamma-ray transient during an optical high-state phase, challenging the current theoretical models for energy extraction from a rotating black hole, while W Comae and Mkn 421 were detected during an AGILE Target of Opportunity (ToO) repointing, and were simultaneously detected by Cherenkov telescopes. Thanks to the rapid dissemination of our alerts, we were able to obtain multi-wavelength ToO data from other observatories such as Spitzer, Swift, RXTE, Suzaku, INTEGRAL, MAGIC, VERITAS, as well as radio-to-optical coverage by means of...

  9. Perspectives on Agile Coaching

    Science.gov (United States)

    Fraser, Steven; Lundh, Erik; Davies, Rachel; Eckstein, Jutta; Larsen, Diana; Vilkki, Kati

    There are many perspectives to agile coaching including: growing coaching expertise, selecting the appropriate coach for your context; and eva luating value. A coach is often an itinerant who may observe, mentor, negotiate, influence, lead, and/or architect everything from team organization to system architecture. With roots in diverse fields ranging from technology to sociology coaches have differing motivations and experience bases. This panel will bring together coaches to debate and discuss various perspectives on agile coaching. Some of the questions to be addressed will include: What are the skills required for effective coaching? What should be the expectations for teams or individu als being coached? Should coaches be: a corporate resource (internal team of consultants working with multiple internal teams); an integral part of a specific team; or external contractors? How should coaches exercise influence and au thority? How should management assess the value of a coaching engagement? Do you have what it takes to be a coach? - This panel will bring together sea soned agile coaches to offer their experience and advice on how to be the best you can be!

  10. User-Centered Agile Methods

    CERN Document Server

    Beyer, Hugh

    2010-01-01

    With the introduction and popularization of Agile methods of software development, existing relationships and working agreements between user experience groups and developers are being disrupted. Agile methods introduce new concepts: the Product Owner, the Customer (but not the user), short iterations, User Stories. Where do UX professionals fit in this new world? Agile methods also bring a new mindset -- no big design, no specifications, minimal planning -- which conflict with the needs of UX design. This lecture discusses the key elements of Agile for the UX community and describes strategie

  11. Agile Project Management For Dummies

    CERN Document Server

    Layton, Mark C

    2012-01-01

    Be flexible and faster with Agile project management As mobile and web technologies continue to evolve rapidly, there is added pressure to develop and implement software projects in weeks instead of months. Agile Project Management For Dummies can make that happen. This is the first book to provide a simple, step-by-step guide to Agile Project Management approaches, tools, and techniques. With the fast pace of mobile and web technology development, software project development must keep pace; Agile Project Management enables developers to complete and implement projects more quickly and this b

  12. Agile foundations principles, practices and frameworks

    CERN Document Server

    Measey, Peter; Gray, Alex; Levy, Richard; Oliver, Les; Roberts, Barbara; Short, Michael; Wilmshurst, Darren; Wolf, Lazaro

    2015-01-01

    Agile practices transform the way organisations carry out business and respond to change. But to realise success, an Agile mindset needs to be adopted throughout an organisation. This book gives a comprehensive introduction to Agile principles and methodologies.

  13. Agile BI – The Future of BI

    Directory of Open Access Journals (Sweden)

    Mihaela MUNTEAN

    2013-01-01

    Full Text Available In a rapidly changing economy, Business Intelligence solutions have to become more agile. This paper attempts to discuss some questions which help in creating an agile BI solution such as: What is Agile? Why agile is so well suited for BI? Which are the key elements that promote an agile BI solution? Also, this paper briefly looks at technologies that can be used for enabling an agile BI solution.

  14. Testing agile requirements models

    Institute of Scientific and Technical Information of China (English)

    BOTASCHANJANJewgenij; PISTERMarkus; RUMPEBernhard

    2004-01-01

    This paper discusses a model-based approach to validate software requirements in agile development processes by simulation and in particular automated testing. The use of models as central development artifact needs to be added to the portfolio of software engineering techniques, to further increase efficiency and flexibility of the development beginning already early in the requirements definition phase. Testing requirements are some of the most important techniques to give feedback and to increase the quality of the result. Therefore testing of artifacts should be introduced as early as possible, even in the requirements definition phase.

  15. Agile Project Portfolio Management

    DEFF Research Database (Denmark)

    Andersen, Jesper Rank; Riis, Jens Ove; Mikkelsen, Hans

    2005-01-01

    This paper will provide a preliminary introduction to the application of Agile Thinking in management of project portfolio and company development. At any point in time, companies have a crowd of development initiatives spread around the organisation and managed at different levels...... in the managerial hierarchy. They compete for resources and managerial attention, and they often take too long time - and some do not survive in the rapid changing context. Top man¬agers ask for speed, flexibility and effectiveness in the portfolio of development activities (projects). But which competencies...

  16. Cost Estimation of Web Projects inContext with Agile Paradigm: Improvements and Validation

    OpenAIRE

    2013-01-01

    Agile practitioners have expressed concern over their inability to correctly estimate costs associated with Agile web software development. This concern has become even more critical as costs associated with development continue to increase. As a result, significant research attention is now intended for gaining a better understanding of the web based projects in context with Agile software-development process as well as constructing and evaluating calibrated software cost estimating tools. T...

  17. THE GENE EXPRESSION PROFILE OF HIGHLY METASTATIC HUMAN OVARIAN CANCER CELL LINE BY GENE CHIP

    Institute of Scientific and Technical Information of China (English)

    吕桂泉; 许沈华; 牟瀚舟; 朱赤红; 羊正炎; 高永良; 楼洪坤; 刘祥麟; 杨文; 程勇

    2001-01-01

    To study the gene expression of high metastatic human ovarian carcinoma cell line (HO-8910PM) and to screen for novel metastasis- associated genes by cDNA microarray. Methods: The cDNA was retro-transcribed from equal quantity mRNA derived from tissues of highly metastatic ovarian carcinoma cell line and normal ovarian, and was labeled with Cy5 and Cy3 fluorescence as probes. The mixed probes were hybridized with BioDoor 4096 double dot human whole gene chip. The chip was scanned by scanArray 3000 laser scanner. The acquired image was analyzed by ImaGene 3.0 software. Results: By applying the cDNA microarray we found: A total of 323 genes whose expression level were 3 times higher or lower in HO-8910PM cell than normal ovarian epithelium cell were screened out, with 71 higher and 252 lower respectively. Among these 10 were new genes. 67 genes showed expression difference bigger than 6 times between HO-8910PM cell and normal ovarian epithelium cell, among these genes 12 were higher, 55 lower, and two new genes were found. Conclusion: cDNA microarray technique is effective in screening the differentially expressed genes between human ovarian cancer cell line (HO-8910PM) and normal ovarian epithelium cell. Using the cDNA microarray to analyze of human ovarian cancer cell line gene expression profile difference will help the gene diagnosis, treatment and protection.

  18. Developing Agility from a Structured Perspective

    Institute of Scientific and Technical Information of China (English)

    陈继祥; 王俭保

    2001-01-01

    Modeling plays an important role in understanding and implementation of manufacturing system under changing competitive environment. Agile manuincturing is a new pattern of production. It is the issue to identify, analyze and evaluate agility for involved people, information,process and organization. There is no commonly accepted analytical structure. The essence of agility is investigated and a model to develop agility is elucidated.

  19. 利用Agilent定制基因芯片筛选相同病理类型、不同预后的早期乳腺癌的分子标记物%Screening molecular markers in early breast cancer of the same pathological types but with different prognoses using Agilent gene chip

    Institute of Scientific and Technical Information of China (English)

    厉周; 金维荣; 彭亮; 韩帅; 黄宗海; 史福军; 蔡寨; 李秀勤; 张普生; 朱卉娟

    2013-01-01

    Objective:To screen molecular markers in early breast cancer and establish gene subtyping-based diagnostic criteria for predicting the prognosis of early breast cancers. Methods Tumor tissue specimens were obtained from 8 patients with early breast cancer for analysis of the differentially expressed genes using Agilent custom 8 × 15 000 chips in combination with the prognostic data of the patients. Another 42 tumor tissue specimens were used to validate the differential genes by real-time fluorescent quantitative PCR. Results Gene microarray analysis identified 132 differentially expressed genes between the patients with favorable and poor prognosis, and 44 of these genes were significantly up-regulated (by over two folds) and 88 down-regulated in patients with poor prognoses. Conclusion The gene expression profiles differ in early breast cancer tissues of the same pathological type but with different clinical stages and prognoses, and CD44, MKI67, NTRK2, Nek2, C16orf60, TOP2A, ANCCA, and RRM2 genes can be used as the prognostic markers for early breast cancer.%目的分析相同病理类型、临床分期(Ⅰ~Ⅱ期)但预后不同的乳腺癌组织的基因表达差异,筛选出有意义的基因组合,寻找与乳腺癌预后相关的基因,探索可以早期预测乳腺癌预后的基因分型诊断标准。方法用Agilent定制人8×15000芯片对筛选出的实验组8例早期乳腺癌患者的组织标本,结合其预后数据,进行差异基因表达分析;采用Real-time PCR技术,在同期收集的验证组42例乳腺癌样本中对差异表达的基因进行验证。结果基因芯片检测分析发现,实验组预后差样本比预后好样本有差异表达基因132个,其中44条基因显著上调,88条基因显著下调(差异均在2倍以上)。结论相同病理类型、临床分期、不同预后的早期乳腺癌组织中基因表达存在显著差异,CD44、MKI67、NTRK2、Nek2、C16orf60、TOP2A、ANCCA、RRM2

  20. An Approach for Agile SOA Development using Agile Principals

    CERN Document Server

    Shahrbanoo, Majlesi; Mehran, Mohsenzadeh

    2012-01-01

    In dynamic and turbulent business environment, the need for success and survival of any organization is the ability of adapting to changes efficiently and cost-effectively. So, for developing software applications, one of the methods is Service Oriented Architecture (SOA) methodology and other is Agile Methodology. Since embracing changes is the indispensable concept of SOA development as well as Agile Development, using an appropriate SOA methodology able to adapt changes even during system development with the preservation of software quality is necessary. In this paper, a new approach consisted of five steps is presented to add agility to SOA methodologies. This approach, before any SOA-based development, helps architect(s) to determine Core Business Processes (CBPs) by using agile principals for establishing Core Architecture. The most important advantage of this approach according to the results of case study is possibility of embracing changes with the preservation of software quality in SOA development...

  1. Agile Software Methodologies: Strength and Weakness

    OpenAIRE

    Dr. Adel Hamdan Mohammad; Dr. Tariq Alwada’n; Dr. Jafar "M.Ali" Ababneh

    2013-01-01

    Agile methodologies are great software development methodologies. No doubt that these methodologies have widespread reputation. The core of agile methodologies is people. Customer and each team member in agiledevelopment teams are the key success or failure factor in agile process. In this paper authors demonstrate strength and weakness points in agile methodologies. Also authors demonstrate how strength and weakness factors can affect the overall results of agile development process.

  2. Elements of an Art - Agile Coaching

    Science.gov (United States)

    Lundh, Erik

    This tutorial gives you a lead on becoming or redefining yourself as an Agile Coach. Introduction to elements and dimensions of state-of-the-art Agile Coaching. How to position the agile coach to be effective in a larger setting. Making the agile transition - from a single team to thousands of people. How to support multiple teams as a coach. How to build a coaches network in your company. Challenges when the agile coach is a consultant and the organization is large.

  3. The Telemetry Agile Manufacturing Effort

    Energy Technology Data Exchange (ETDEWEB)

    Brown, K.D.

    1995-01-01

    The Telemetry Agile Manufacturing Effort (TAME) is an agile enterprising demonstration sponsored by the US Department of Energy (DOE). The project experimented with new approaches to product realization and assessed their impacts on performance, cost, flow time, and agility. The purpose of the project was to design the electrical and mechanical features of an integrated telemetry processor, establish the manufacturing processes, and produce an initial production lot of two to six units. This paper outlines the major methodologies utilized by the TAME, describes the accomplishments that can be attributed to each methodology, and finally, examines the lessons learned and explores the opportunities for improvement associated with the overall effort. The areas for improvement are discussed relative to an ideal vision of the future for agile enterprises. By the end of the experiment, the TAME reduced production flow time by approximately 50% and life cycle cost by more than 30%. Product performance was improved compared with conventional DOE production approaches.

  4. Improving Global Development Using Agile

    Science.gov (United States)

    Avritzer, Alberto; Bronsard, Francois; Matos, Gilberto

    Global development promises important productivity and capability advantages over centralized work by optimally allocating tasks according to locality, expertise or cost. All too often, global development also introduces a different set of communication and coordination challenges that can negate all the expected benefits and even cause project failures. Most common problems have to do with building trust or quick feedback loops between distributed teams, or with the integration of globally developed components. Agile processes tend to emphasize the intensity of communication, and would seem to be negatively impacted by team distribution. In our experience, these challenges can be overcome, and agile processes can address some of the pitfalls of global development more effectively than plan-driven development. This chapter discusses how to address the difficulties faced when adapting agile processes to global development and the improvements to global development that adopting agile can produce.

  5. E3 ligase CHIP and Hsc70 regulate Kv1.5 protein expression and function in mammalian cells.

    Science.gov (United States)

    Li, Peili; Kurata, Yasutaka; Maharani, Nani; Mahati, Endang; Higaki, Katsumi; Hasegawa, Akira; Shirayoshi, Yasuaki; Yoshida, Akio; Kondo, Tatehito; Kurozawa, Youichi; Yamamoto, Kazuhiro; Ninomiya, Haruaki; Hisatome, Ichiro

    2015-09-01

    Kv1.5 confers ultra-rapid delayed-rectifier potassium channel current (IKur) which contributes to repolarization of the atrial action potential. Kv1.5 proteins, degraded via the ubiquitin-proteasome pathway, decreased in some atrial fibrillation patients. Carboxyl-terminus heat shock cognate 70-interacting protein (CHIP), an E3 ubiquitin ligase, is known to ubiquitinate short-lived proteins. Here, we investigated the roles of CHIP in Kv1.5 degradation to provide insights into the mechanisms of Kv1.5 decreases and treatments targeting Kv1.5 for atrial fibrillation. Coexpression of CHIP with Kv1.5 in HEK293 cells increased Kv1.5 protein ubiquitination and decreased the protein level. Immunofluorescence revealed decreases of Kv1.5 proteins in the endoplasmic reticulum and on the cell membrane. A siRNA against CHIP suppressed Kv1.5 protein ubiquitination and increased its protein level. CHIP mutants, lacking either the N-terminal tetratricopeptide region domain or the C-terminal U-box domain, failed to exert these effects on Kv1.5 proteins. Immunoprecipitation showed that CHIP formed complexes with Kv1.5 proteins and heat shock cognate protein 70 (Hsc70). Effects of Hsc70 on Kv1.5 were similar to CHIP by altering interaction of CHIP with Kv1.5 protein. Coexpression of CHIP and Hsc70 with Kv1.5 additionally enhanced Kv1.5 ubiquitination. Kv1.5 currents were decreased by overexpression of CHIP or Hsc70 but were increased by knockdown of CHIP or Hsc70 in HEK 293 cells stably expressing Kv1.5. These effects of CHIP and Hsc70 were also observed on endogenous Kv1.5 in HL-1 mouse cardiomyocytes, decreasing IKur and prolonging action potential duration. These results indicate that CHIP decreases the Kv1.5 protein level and functional channel by facilitating its degradation in concert with chaperone Hsc70.

  6. The Art of Agile Development

    CERN Document Server

    Shore, James

    2008-01-01

    Plenty of books describe what agile development is or why it helps software projects succeed, but very few combine information for developers, managers, testers, and customers into a single package that they can apply directly. This book provides a gestalt view of the agile development process that serves as a comprehensive introduction for non-technical readers, along with hands-on technical practices for programmers and developers. The book also tackles the people aspect of Extreme Programming.

  7. Inserting Agility in System Development

    Science.gov (United States)

    2012-07-01

    Agile IT Acquisition, IT Box, Scrum Inserting Agility in System Development Matthew R. Kennedy and Lt Col Dan Ward, USAF With the fast-paced nature...1,700 individuals and 71 countries, found Scrum and eXtreme Programming to be the most widely followed method- ologies (VersionOne, 2007). Other...University http://www.dau.mil 259 Defense ARJ, July 2012, Vol. 19 No. 3 : 249–264 Scrum Scrum is a framework used for project management, which is

  8. Focused Logistics: Putting Agility in Agile Logistics

    Science.gov (United States)

    2011-05-19

    list, ahead of companies like American Express, DuPont and Coca Cola ; Supports nearly 1,900 weapon systems; DLA manages eight supply chains and...the strategic, operational, and tactical levels of war. Sense and Respond Logistics promotes doctrinal and organizational transformation, and supports

  9. Human factors in agile manufacturing

    Energy Technology Data Exchange (ETDEWEB)

    Forsythe, C.

    1995-03-01

    As industries position themselves for the competitive markets of today, and the increasingly competitive global markets of the 21st century, agility, or the ability to rapidly develop and produce new products, represents a common trend. Agility manifests itself in many different forms, with the agile manufacturing paradigm proposed by the Iacocca Institute offering a generally accepted, long-term vision. In its many forms, common elements of agility or agile manufacturing include: changes in business, engineering and production practices, seamless information flow from design through production, integration of computer and information technologies into all facets of the product development and production process, application of communications technologies to enable collaborative work between geographically dispersed product development team members and introduction of flexible automation of production processes. Industry has rarely experienced as dramatic an infusion of new technologies or as extensive a change in culture and work practices. Human factors will not only play a vital role in accomplishing the technical and social objectives of agile manufacturing. but has an opportunity to participate in shaping the evolution of industry paradigms for the 21st century.

  10. Gene expression profile differences in gastric cancer, pericancerous epithelium and normal gastric mucosa by gene chip

    Institute of Scientific and Technical Information of China (English)

    Chuan-Ding Yu; Shen-Hua Xu; Hang-Zhou Mou; Zhi-Ming Jiang; Chi-Hong Zhu; Xiang-Lin Liu

    2005-01-01

    AIM: To study the difference of gene expression in gastric cancer (T), pericancerous epithelium (P) and normal tissue of gastric mucosa (C), and to screen an associated novel gene in early gastric carcinogenesis by oligonudeotide microarray.METHODS: U133A (Affymetrix, Santa Clara, CA) gene chip was used to detect the gene expression profile difference in T, P and C, respectively. Bioinformatics was used to analyze the detected results.RESULTS: When gastric cancer was compared with normal gastric mucosa, 766 genes were found, with a difference of more than four times in expression levels. Of the 766 genes,530 were up-regulated (Signal Log Ratio [SLR]>2), and 236 were down-regulated (SLR<-2). When pericancerous epithelium was compared with normal gastric mucosa, 64genes were found, with a difference of more than four times in expression levels. Of the 64 genes, 50 were up-regulated (SLR>2), and 14 were down-regulated (SLR<-2). Compared with normal gastric mucosa, a total of 143 genes with a difference in expression levels (more than four times, either in cancer or in pericancerous epithelium) were found in gastric cancer (T) and pericancerous epithelium (P). Of the 143 genes, 108 were up-regulated (SLR>2), and 35were down-regulated (SLR<-2).CONCLUSION: To apply a gene chip could find 143 genes associated with the genes of gastric cancer in pericancerous epithelium, although there were no pathological changes in the tissue slices. More interesting, six genes of pericancerous epithelium were up-regulated in comparison with genes of gastric cancer and three genes were down-regulated in comparison with genes of gastric cancer. It is suggested that these genes may be related to the carcinogenesis and development of early gastric cancer.

  11. AGILE integration into APC for high mix logic fab

    Science.gov (United States)

    Gatefait, M.; Lam, A.; Le Gratiet, B.; Mikolajczak, M.; Morin, V.; Chojnowski, N.; Kocsis, Z.; Smith, I.; Decaunes, J.; Ostrovsky, A.; Monget, C.

    2015-09-01

    For C040 technology and below, photolithographic depth of focus control and dispersion improvement is essential to secure product functionality. Critical 193nm immersion layers present initial focus process windows close to machine control capability. For previous technologies, the standard scanner sensor (Level sensor - LS) was used to map wafer topology and expose the wafer at the right Focus. Such optical embedded metrology, based on light reflection, suffers from reading issues that cannot be neglected anymore. Metrology errors are correlated to inspected product area for which material types and densities change, and so optical properties are not constant. Various optical phenomena occur across the product field during wafer inspection and have an effect on the quality and position of the reflected light. This can result in incorrect heights being recorded and exposures possibly being done out of focus. Focus inaccuracy associated to aggressive process windows on critical layers will directly impact product realization and therefore functionality and yield. ASML has introduced an air gauge sensor to complement the optical level sensor and lead to optimal topology metrology. The use of this new sensor is managed by the AGILE (Air Gauge Improved process LEveling) application. This measurement with no optical dependency will correct for optical inaccuracy of level sensor, and so improve best focus dispersion across the product. Due to the fact that stack complexity is more and more important through process steps flow, optical perturbation of standard Level sensor metrology is increasing and is becoming maximum for metallization layers. For these reasons AGILE feature implementation was first considered for contact and all metal layers. Another key point is that standard metrology will be sensitive to layer and reticle/product density. The gain of Agile will be enhanced for multiple product contribution mask and for complex System on Chip. Into ST context (High

  12. RFP for the italien satellite AGILE

    DEFF Research Database (Denmark)

    Madsen, Peter Buch; Jørgensen, John Leif; Riis, Troels

    1999-01-01

    The document descibes the ASC Star Tracker (performance, functionality, requirements etc.) to the Italian satellite AGILE.......The document descibes the ASC Star Tracker (performance, functionality, requirements etc.) to the Italian satellite AGILE....

  13. Collaborative Environment and Agile Development

    Directory of Open Access Journals (Sweden)

    Bogdan GHILIC-MICU

    2014-01-01

    Full Text Available Over time, information and communications technology development has made a direct impact on human activity in the individual context as well as familial, economic and social. This has laid the premise for adoption of new and modern paradigms in individual and organizational activity management. The evolutionary climax of the social universe is called nowadays knowledge society. The knowledge society succeeds the information society, emphasizing the development of the opportunities brought by collaborative work environment and agile approach. In this paper we will highlight the use of collaborative environment in agile software development, as an instrument for managing organizations in knowledge society. Thus, we will emphasize the paradigms of agile testing, validation and verification in collaborative environment.

  14. User-centered agile method

    CERN Document Server

    Deuff, Dominique

    2013-01-01

    Agile development methods began to emerge around 20 years ago. However, it was not until the early 2000s that they began to be widely used in industry. This growth was often due to the advent of Internet services requiring faster cycles of development in order to heighten the rate at which an ever-greater number of functionalities were made available. In parallel, user-centered design (UCD) methods were also becoming more and more widely used: hence, user-centered design and agile methods were bound to cross paths, at least in the telecoms industry! During this period, in the field of telec

  15. Generalizing Agile Software Development Life Cycle

    Directory of Open Access Journals (Sweden)

    S. Bhalerao

    2009-11-01

    Full Text Available In last decade, various agile methods have been introduced and used by software industry. It has been observed that many practitioners are using hybrid of agile methods and traditional methods. The knowledge of agile software development process about the theoretical grounds, applicability in large development settings and connections to establish software engineering disciplines remain mostly in dark. It has been reported that it is difficult for average manager to implement agile method in the organization. Further, every agile method has its own development cycle that brings technological, managerial and environmental changes in organization. A proper roadmap of agile software development in the form of agile software development life cycle can be developed to address the aforesaid issues of agile software development process. Thus, there is strong need of agile software development life cycle that clearly defines the phases included in any agile method and also describes the artifacts of each phase. This generalization of agile software development life cycle provides the guideline for average developers about usability, suitability, applicability of agile methods.

  16. Usability Evaluation Method for Agile Software Development

    Directory of Open Access Journals (Sweden)

    Saad Masood Butt

    2015-02-01

    Full Text Available Agile methods are the best fit for tremendously growing software industry due to its flexible and dynamic nature. But the software developed using agile methods do meet the usability standards? To answer this question we can see that majority of agile software development projects currently involve interactive user interface designs, which can only be possible by following User Centered Design (UCD in agile methods. The question here is, how to integrate UCD with agile models. Both Agile models and UCD are iterative in nature but agile models focus on coding and development of software; whereas, UCD focuses on user interface of the software. Similarly, both of them have testing features where the agile model involves automated tested code while UCD involves an expert or a user to test the user interface. In this paper, a new agile usability model is proposed and the evaluation is of the proposed model is presented by practically implementing it in three real life projects. . Key results from these projects clearly show: the proposed agile model incorporates usability evaluation methods, improves the relationship between usability experts to work with agile software experts; in addition, allows agile developers to incorporate the result from UCD into subsequent interactions.

  17. Everything you want to know about Agile

    CERN Document Server

    Cooke, Jamie Lynn

    2012-01-01

    Everything you want to know about Agile comprehensively addresses the issues that IT departments face when they try to implement Agile approaches within the constraints of their traditional organizations, including existing project frameworks, budgeting structures, contracts and corporate reporting.  It is an essential resource for IT departments that want to deliver successful Agile results, even in the most challenging environments.

  18. Difference of gene expression profiles between esophageal carcinoma and its pericancerous epithelium by gene chip

    Institute of Scientific and Technical Information of China (English)

    Shen-Hua Xu; Li-Juan Qian; Han-Zhou Mou; Chi-Hong Zhu; Xing-Ming Zhou; Xiang-Lin Liu; Yong Chen; Wen-Yu Bao

    2003-01-01

    AIM: To study the difference of gene expression between esophageal carcinoma and its pericancerous epithelium and to screen novel associated genes in the early stage of esophageal carcinogenesis by cDNA microarray.METHODS: Total RNA was extracted with the original single step way from esophageal carcinoma, its pericancerous epithelial tissue and normal esophageal epithelium far from the tumor. The cDNA retro-transcribed from equal quantity of mRNA was labeled with Cy5 and Cy3 fluorescence functioning as probes. The mixed probes were hybridized with two pieces of BioDoor 4 096 double dot human whole gene chip. Fluorescence signals were scanned by ScanArray 3 000 laser scanner and farther analyzed by ImaGene 3.0software with the digital computer.RESULTS: (1) A total of 135 genes were screened out, in which 85 and 50 genes whose the gene expression levels (fluorescence intensity) in esophageal carcinoma were more than 2 times and less than 0.5 times respectively compared with the normal esophageal epithelium. (2) There were also total 31 genes, among then 27 and 4 whose expressions in pericancerous tissue were 2-fold up-regulated and 0.5-fold down-regulated respectively compared with normal esophageal epithelium. (3) There were 13 genes appeared simultaneously in both pericancerous epithelium and esophageal carcinoma, while another 18 genes existed in pericancerous epithelium only.CONCLUSION: With the parallel comparison among these three gene profiles, it was shown that (1). A total of 135genes, Whose expression difference manifested as fluorescence intensity were more than 2 times between esophageal carcinoma and normal esophageal epithelium,were probably related to the occurrence and development of the esophageal carcinoma. (2). The 31 genes showing expression difference more than 2 times between pericancerous and normal esophageal epithelium might be relate to the promotion of esophageal pericancerosis and its progress. The present study illustrated that by using

  19. The Challenges of Becoming Agile

    DEFF Research Database (Denmark)

    Ovesen, Nis; Dowlen, Chris

    2012-01-01

    During the last decade agile methods have been a vast success in the domain of software development. This paper investigates whether these methods can be successfully transferred to the domain of physical product development in order to address the fundamental challenges of increased marked speed...

  20. AGILE DRAFTING OF OUTSOURCING CONTRACTS

    DEFF Research Database (Denmark)

    Schlichter, Bjarne Rerup; Storgaard, Kristian

    2015-01-01

    and in several parallel tracks using different competencies. By the use of an illustrative case-study, this paper explores how scrum can be applied to enhance the process of drafting outsourcing contracts. The analysis indicates that the use of an agile method, such as Scrum, can be beneficial in this context...

  1. Pro Agile NET Development with Scrum

    CERN Document Server

    Blankenship, Jerrel; Millett, Scott

    2011-01-01

    Pro Agile .NET Development with SCRUM guides you through a real-world ASP.NET project and shows how agile methodology is put into practice. There is plenty of literature on the theory behind agile methodologies, but no book on the market takes the concepts of agile practices and applies these in a practical manner to an end-to-end ASP.NET project, especially the estimating, requirements and management aspects of a project. Pro Agile .NET Development with SCRUM takes you through the initial stages of a project - gathering requirements and setting up an environment - through to the development a

  2. AGILE METHODS AND QUALITY _ A SURVEY

    Directory of Open Access Journals (Sweden)

    BODJE N'Kauh Nathan-Regis

    2013-12-01

    Full Text Available Agile software processes, such as extreme programming (XP, Scrum, Lean, etc., rely on best practices that are considered to improve software development quality. It can be said that best practices aim to induce software quality assurance (SQA into the project at hand. Some researchers of agile methods claim that because of the very nature of such methods, quality in agile software projects should be a natural outcome of the applied method. As a consequence, agile quality is expected to be more or less embedded in the agile software processes. Many reports support and evangelize the advantages of agile methods with respect to quality assurance, Is it so ? An ambitious goal of this paper is to present work done to understand how quality is or should be handled. This paper as all survey papers attempt to summarize and organizes research results in the field of software engineering, precisely for the topic of agile methods related to software quality.

  3. A Disciplined Approach to Adopting Agile Practices: The Agile Adoption Framework

    CERN Document Server

    Sidky, Ahmed; Bohner, Shawn

    2007-01-01

    Many organizations aspire to adopt agile processes to take advantage of the numerous benefits that it offers to an organization. Those benefits include, but are not limited to, quicker return on investment, better software quality, and higher customer satisfaction. To date however, there is no structured process (at least in the public domain) that guides organizations in adopting agile practices. To address this problem we present the Agile Adoption Framework. The framework consists of two components: an agile measurement index, and a 4-Stage process, that together guide and assist the agile adoption efforts of organizations. More specifically, the agile measurement index is used to identify the agile potential of projects and organizations. The 4-Stage process, on the other hand, helps determine (a) whether or not organizations are ready for agile adoption, and (b) guided by their potential, what set of agile practices can and should be introduced.

  4. A combined strategy of "in silico" transcriptome analysis and web search engine optimization allows an agile identification of reference genes suitable for normalization in gene expression studies.

    Science.gov (United States)

    Faccioli, Primetta; Ciceri, Gian Paolo; Provero, Paolo; Stanca, Antonio Michele; Morcia, Caterina; Terzi, Valeria

    2007-03-01

    Traditionally housekeeping genes have been employed as endogenous reference (internal control) genes for normalization in gene expression studies. Since the utilization of single housekeepers cannot assure an unbiased result, new normalization methods involving multiple housekeeping genes and normalizing using their mean expression have been recently proposed. Moreover, since a gold standard gene suitable for every experimental condition does not exist, it is also necessary to validate the expression stability of every putative control gene on the specific requirements of the planned experiment. As a consequence, finding a good set of reference genes is for sure a non-trivial problem requiring quite a lot of lab-based experimental testing. In this work we identified novel candidate barley reference genes suitable for normalization in gene expression studies. An advanced web search approach aimed to collect, from publicly available web resources, the most interesting information regarding the expression profiling of candidate housekeepers on a specific experimental basis has been set up and applied, as an example, on stress conditions. A complementary lab-based analysis has been carried out to verify the expression profile of the selected genes in different tissues and during heat shock response. This combined dry/wet approach can be applied to any species and physiological condition of interest and can be considered very helpful to identify putative reference genes to be shortlisted every time a new experimental design has to be set up.

  5. Process-oriented evaluation of agile business processes

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Agile enterprises are built based on agile business processes.Simultaneously,agile enterprises must be able to utilize agile business processes to rapidly respond market opportunities and maintain enterprises'competitions.But how to evaluate and choose agile business processes is a key problem about building agile enterprises.The paper proposes a goal driven method and an evaluation architecture for business processes' agility.Furthermore,a four-layer configuring model for agile business processes is developed based on the evaluation architecture and it can evaluate and configure agile business processes among alternatives.

  6. Systems engineering agile design methodologies

    CERN Document Server

    Crowder, James A

    2013-01-01

    This book examines the paradigm of the engineering design process. The authors discuss agile systems and engineering design. The book captures the entire design process (functionbases), context, and requirements to affect real reuse. It provides a methodology for an engineering design process foundation for modern and future systems design. This book captures design patterns with context for actual Systems Engineering Design Reuse and contains a new paradigm in Design Knowledge Management.

  7. An Investigation of Agility Issues in Scrum Teams Using Agility Indicators

    Science.gov (United States)

    Pikkarainen, Minna; Wang, Xiaofeng

    Agile software development methods have emerged and become increasingly popular in recent years; yet the issues encountered by software development teams that strive to achieve agility using agile methods are yet to be explored systematically. Built upon a previous study that has established a set of indicators of agility, this study investigates what issues are manifested in software development teams using agile methods. It is focussed on Scrum teams particularly. In other words, the goal of the chapter is to evaluate Scrum teams using agility indicators and therefore to further validate previously presented agility indicators within the additional cases. A multiple case study research method is employed. The findings of the study reveal that the teams using Scrum do not necessarily achieve agility in terms of team autonomy, sharing, stability and embraced uncertainty. The possible reasons include previous organizational plan-driven culture, resistance towards the Scrum roles and changing resources.

  8. Conceptualizing Interpersonal Relationships in Agile IS Development

    DEFF Research Database (Denmark)

    Madsen, Sabine; Matook, Sabine

    Agile information systems development (ISD) is a people-centered approach that emphasizes frequent interaction and genuine co-operation between customers and developers. While business relationships are the norm in the workplace, agile ISD leads to the creation of close interpersonal relationships....... Drawing on relationship theory and friendship literature we propose a theoretical framework of three types of workplace relationships. The framework is used for deriving theoretical preconceptions about agile relationships and their impact on the agile ISD team’s ability to deliver valuable, working...... software frequently. We also present the interpretive approach we will apply. An understanding of the relationship specific aspects of agile ISD as well as of the importance and impact of certain relationship characteristics can help explain why some agile projects succeed, while others fail...

  9. Case-based Agile Fixture Design

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    In order to realize the agility of the fixture design, such asreconfigurability, rescalability and reusability, fixture structure is function unit-based decomposed from a fire-new point of view. Which makes it easy for agile fixture to be reconfigured and modified. Thereby, the base of case-based agile fixture design system info is established.Whole case-based agile fixture design model is presented. In which, three modules are added relative to the other models, including case matching of fixture planning module, conflict arbitration module and agile fixture case modify module. The three modules could solve the previous problem that the experience and result are difficult to be reused in the process of design.Two key techniques in the process of the agile fixture design, the evaluation of case similarity, and restriction-based conflict arbitration, are listed. And some methods are presented to evaluate the similarity and clear up the conflict.

  10. An essay on agile project management practices

    OpenAIRE

    Gouveia, Daniel Rabasquinho

    2015-01-01

    The main goals for the current dissertation is to research on how practices and concepts from Agile Project Management can be applied in a non-IT context and to discover which aspects should be considered when deciding if whether an Agile approach should be implemented or not. Previous studies reflect on the adoption for the identified context. However, the recognition of these practices and concepts by the Project Management field of studies still remains unresolved. The adoption of Agile...

  11. Towards a Comparative Measure of Legged Agility

    Science.gov (United States)

    2014-06-01

    so for this paper we explore the implications of a well-cited definition within the sports science community holding that agility is “a rapid whole...systems will have negligible agility according to our metric in accor- dance with biological observations that these motions require significantly less...W. Young, “Agility literature review: Classifications, training and testing,” Journal of sports sciences, vol. 24, no. 9, pp. 919–932, 2006. 19. D. L

  12. Teamwork in Distributed Agile Software Development

    OpenAIRE

    Gurram, Chaitanya; Bandi, Srinivas Goud

    2013-01-01

    Context: Distributed software development has become a most desired way of software development. Application of agile development methodologies in distributed environments has taken a new trend in developing software due to its benefits of improved communication and collaboration. Teamwork is an important concept that agile methodologies facilitate and is one of the potential determinants of team performance which was not focused in distributed agile software development. Objectives: This res...

  13. WOFIE, linear to agile learning design

    DEFF Research Database (Denmark)

    Rosenstand, Claus Andreas Foss; Tribler, Nanna

    2012-01-01

    Wofie: A four-day Workshop For Innovation and Entrepreneurship at Aalborg University. Area of interest: Agile learning design. The research question: How to design an agile learning process with both progression and empowered students? The work method is action research framed through on-line eva......Wofie: A four-day Workshop For Innovation and Entrepreneurship at Aalborg University. Area of interest: Agile learning design. The research question: How to design an agile learning process with both progression and empowered students? The work method is action research framed through on...

  14. Evaluation of Agile Manufacturing Enterprises%Evaluation of Agile Manufacturing Enterprises

    Institute of Scientific and Technical Information of China (English)

    黄新刚; 王先逵; 刘成颖

    2001-01-01

    Agile manufacturing is an important manufacturing philosophy todevelop advanced manufacturing enterprises to improve competivity. The evaluation of Agile Manufacturing Enterprises (AME) is one of the key activities in implementing agile manufacturing. This paper proposes a method for evaluating AME, establishes a basic feature model of AME based on the feature tree and discusses the hierarchical decomposition algorithm based on the model with an example.

  15. Research on Evaluation on Agility of Agile Supply Chain Network Based on Complex Network Theory

    Directory of Open Access Journals (Sweden)

    Nai-Ru Xu

    2015-01-01

    Full Text Available The paper tries to add the network structure factors of agile supply chain network into agility evaluation. The paper firstly presents three concepts including node strength centrality, betweenness centrality, and network centrality. They are used to calculate the weight of node enterprises in the agile supply chain network. And then, a series of agility indicators are designed to evaluate agility of agile supply chain network. AHP is used to calculate the weight of the indicators. Next, these indicators are used to get initial agility evaluation matrix by means of Delphi method, Data Mining, and so forth. Then FCE is used to calculate the membership degree on agility of node enterprises by combining the evaluation matrix with the weight of indicators. Last, the evaluation result of comprehensive agility of agile supply chain network is calculated on the basis of considering the weight of node enterprises. This method can reflect the effect which the network structure of supply chain network makes on the agility of the supply chain network. It is a complement to the current evaluation methods of agility.

  16. Agile! the good, the hype and the ugly

    CERN Document Server

    Meyer, Bertrand

    2014-01-01

    Here is the ideal introduction to agile development. The book details agile principles, roles, managerial practices, technical practices and artifacts, offering a complete review that will help readers master all the important agile ideas.

  17. Agile Contracts: Designing an Agile Team Selection Guideline

    DEFF Research Database (Denmark)

    Pries-Heje, Lene; Pries-Heje, Jan

    2014-01-01

    with “endless” re-negotiation of the requirements; you need a more flexible way to develop IS. A new way of coping with many changes is to use an agile development approach and a fixed budget and resources contract. This paper presents an example case. We analyse the case and design a guideline for how...... to implement a fixed budget and resources contract in the public sector. The guideline includes elements to cope with challenges in a tender process such as transparency, criteria for supplier selection, and live assessment of resource skills and capabilities, as well as achieving the flexibility for change...

  18. Chip, Chip, Hooray!

    Science.gov (United States)

    Kelly, Susan

    2001-01-01

    Presents a science laboratory using different brands of potato chips in which students test their oiliness, size, thickness, saltiness, quality, and cost, then analyze the results to determine the best chip. Gives a brief history of potato chips. (YDS)

  19. Evaluation of the Agility Level of the Organization

    Directory of Open Access Journals (Sweden)

    Linkevics Gusts

    2015-12-01

    Full Text Available Organizations and teams are switching to agile methodology more and more often. The problem lies in the fact that organizations and teams are not certain at which agility level they currently are and at which agility domains they fail. This research focuses on creating a new method and tool for evaluation of the agility level of the company. The proposed method is based on the agility model of the company with agility domains, subdomains and attributes. Expert evaluation of domains, subdomains and attributes is the core of this method. The result of this research is the agility assessment method and blueprint of the architecture for the agility evaluation tool.

  20. Agile Project Management with Scrum

    CERN Document Server

    Schwaber, Ken

    2009-01-01

    The rules and practices for Scrum-a simple process for managing complex projects-are few, straightforward, and easy to learn. But Scrum's simplicity itself-its lack of prescription-can be disarming, and new practitioners often find themselves reverting to old project management habits and tools and yielding lesser results. In this illuminating series of case studies, Scrum co-creator and evangelist Ken Schwaber identifies the real-world lessons-the successes and failures-culled from his years of experience coaching companies in agile project management. Through them, you'll understand how to

  1. The RITE Approach to Agile Acquisition

    Science.gov (United States)

    2013-04-01

    Review (SVR), and Production Readiness Review ( PRR ), which were evaluated against Agile development requirements. Further analysis was conducted...Audit (FCA), PRR , Operational Test Readiness Review (OTRR), Physical Configuration Audit (PCA), Integration Readiness Review (IRR), In Service...Technology (DSB Task Force, 2009, p. 48) In the context of the primary milestone reviews (PDR, CDR, and SVR/ PRR ), a nominal Agile development structure was

  2. Agile Values and Their Implementation in Practice

    Directory of Open Access Journals (Sweden)

    Eva Maria Schön

    2015-12-01

    Full Text Available Today agile approaches are often used for the development of digital products. Since their development in the 90s, Agile Methodologies, such as Scrum and Extreme Programming, have evolved. Team collaboration is strongly influenced by the values and principles of the Agile Manifesto. The values and principles described in the Agile Manifesto support the optimization of the development process. In this article, the current operation is analyzed in Agile Product Development Processes. Both, the cooperation in the project team and the understanding of the roles and tasks will be analyzed. The results are set in relation to the best practices of Agile Methodologies. A quantitative questionnaire related to best practices in Agile Product Development was developed. The study was carried out with 175 interdisciplinary participants from the IT industry. For the evaluation of the results, 93 participants were included who have expertise in the subject area Agile Methodologies. On one hand, it is shown that the collaborative development of product-related ideas brings benefits. On the other hand, it is investigated which effect a good understanding of the product has on decisions made during the implementation. Furthermore, the skillset of product managers, the use of pair programming, and the advantages of cross-functional teams are analyzed.

  3. Applying Lean on Agile Scrum Development Methodology

    Directory of Open Access Journals (Sweden)

    SurendRaj Dharmapal

    2015-11-01

    Full Text Available This journal introduces the reader to Agile and Lean concepts and provides a basic level of understanding of each process. This journal will also provide a brief background about applying Lean concepts on each phase of agile scrum methodology and summarize their primary business advantages for delivering value to customer.

  4. Applying Lean on Agile Scrum Development Methodology

    Directory of Open Access Journals (Sweden)

    SurendRaj Dharmapal

    2014-03-01

    Full Text Available This journal introduces the reader to Agile and Lean concepts and provides a basic leve l of understanding of each process. This journal will also provide a brief background about applying Lean concepts on each phase of agile scrum methodology and summarize their primary business advantages for delivering value to customer.

  5. The GLAST-AGILE Support Program (GASP)

    Science.gov (United States)

    Villata, M.; Raiteri, C. M.; Webt Collaboration

    2008-10-01

    The GLAST-AGILE Support Program (GASP) was organized within the Whole Earth Blazar Telescope to provide optical-to-radio long-term continuous monitoring of a list of selected gamma-ray-loud blazars during the operation of the AGILE and GLAST satellites. We present some results obtained since its birth, in September 2007.

  6. Teaching Agile Software Development: A Case Study

    Science.gov (United States)

    Devedzic, V.; Milenkovic, S. R.

    2011-01-01

    This paper describes the authors' experience of teaching agile software development to students of computer science, software engineering, and other related disciplines, and comments on the implications of this and the lessons learned. It is based on the authors' eight years of experience in teaching agile software methodologies to various groups…

  7. Hepatic gene expression profiling using GeneChips in zebrafish exposed to 17{alpha}-methyldihydrotestosterone

    Energy Technology Data Exchange (ETDEWEB)

    Hoffmann, J.L.; Thomason, R.G.; Lee, D.M.; Brill, J.L.; Price, B.B.; Carr, G.J. [Miami Valley Innovation Center, Procter and Gamble Company, P.O. Box 538707, Cincinnati, OH 45253-8707 (United States); Versteeg, D.J. [Miami Valley Innovation Center, Procter and Gamble Company, P.O. Box 538707, Cincinnati, OH 45253-8707 (United States)], E-mail: versteeg.dj@pg.com

    2008-04-28

    Concentration and time-dependent changes in hepatic gene expression were examined in adult, female zebrafish (Danio rerio) exposed to 0, 0.1, 0.7, 4.9 {mu}g/L of a model androgen, 17{alpha}-methyldihydrotestosterone (MDHT). At 24 and 168 h, fish were sacrificed and liver was extracted for gene expression analysis using custom Affymetrix GeneChip Zebrafish Genome Microarrays. In an effort to link gene expression changes to higher levels of biological organization, blood was collected for measurement of plasma steroid hormones (17{beta}-estradiol (E2), testosterone (T)) and vitellogenin (VTG) using ELISA. Body and ovary weight were also measured. A significant reduction in E2 occurred at 24 h (0.7 and 4.9 {mu}g/L) and 168 h (4.9 {mu}g/L) following MDHT exposure. In contrast, T was significantly increased at 24 h (4.9 {mu}g/L) and 168 h (0.1, 0.7, 4.9 {mu}g/L). 171 and 575 genes were significantly affected in a concentration-dependent manner at either 24 or 168 h by MDHT exposure at p {<=} 0.001 and p {<=} 0.01, respectively. Genes involved in retinoic acid metabolism (e.g. aldehyde dehydrogenase 8, member A1; retinol dehydrogenase 12), steroid biosynthesis and metabolism (e.g. hydroxysteroid (11{beta}) dehydrogenase 2; hydroxy-delta-5-steroid dehydrogenase, 3 beta-), hormone transport (e.g. sex hormone binding globulin), and regulation of cell growth and proliferation (e.g. N-myc downstream regulated gene 1; spermidinespermine N(1)-acetyltransferase) were affected by MDHT exposure. In this study, we identified genes involved in a variety of biological processes that have the potential to be used as markers of exposure to androgenic substances. Genes identified in this study provide information on the potential mode of action of strong androgens in female fish. In addition, when used for screening of EDC's, these genes may also serve as sensitive markers of exposure to androgenic compounds.

  8. Agile manufacturing from a statistical perspective

    Energy Technology Data Exchange (ETDEWEB)

    Easterling, R.G. [Sandia National Labs., Albuquerque, NM (United States). New Initiatives Dept.

    1995-10-01

    The objective of agile manufacturing is to provide the ability to quickly realize high-quality, highly-customized, in-demand products at a cost commensurate with mass production. More broadly, agility in manufacturing, or any other endeavor, is defined as change-proficiency; the ability to thrive in an environment of unpredictable change. This report discusses the general direction of the agile manufacturing initiative, including research programs at the National Institute of Standards and Technology (NIST), the Department of Energy, and other government agencies, but focuses on agile manufacturing from a statistical perspective. The role of statistics can be important because agile manufacturing requires the collection and communication of process characterization and capability information, much of which will be data-based. The statistical community should initiate collaborative work in this important area.

  9. Some Findings Concerning Requirements in Agile Methodologies

    Science.gov (United States)

    Rodríguez, Pilar; Yagüe, Agustín; Alarcón, Pedro P.; Garbajosa, Juan

    Agile methods have appeared as an attractive alternative to conventional methodologies. These methods try to reduce the time to market and, indirectly, the cost of the product through flexible development and deep customer involvement. The processes related to requirements have been extensively studied in literature, in most cases in the frame of conventional methods. However, conclusions of conventional methodologies could not be necessarily valid for Agile; in some issues, conventional and Agile processes are radically different. As recent surveys report, inadequate project requirements is one of the most conflictive issues in agile approaches and better understanding about this is needed. This paper describes some findings concerning requirements activities in a project developed under an agile methodology. The project intended to evolve an existing product and, therefore, some background information was available. The major difficulties encountered were related to non-functional needs and management of requirements dependencies.

  10. Gene Expression Analysis Using Agilent DNA Microarrays

    DEFF Research Database (Denmark)

    Stangegaard, Michael

    2009-01-01

    of labeled cDNA added to each slide reduces dye-bias and slide to slide variation. Efficient mixing of the hybridization solution throughout the hybridization reaction increases signals several fold. The amount of near perfect target-probe hybrids may be reduced by efficient stringency washes...

  11. Opening up the Agile Innovation Process

    Science.gov (United States)

    Conboy, Kieran; Donnellan, Brian; Morgan, Lorraine; Wang, Xiaofeng

    The objective of this panel is to discuss how firms can operate both an open and agile innovation process. In an era of unprecedented changes, companies need to be open and agile in order to adapt rapidly and maximize their innovation processes. Proponents of agile methods claim that one of the main distinctions between agile methods and their traditional bureaucratic counterparts is their drive toward creativity and innovation. However, agile methods are rarely adopted in their textbook, "vanilla" format, and are usually adopted in part or are tailored or modified to suit the organization. While we are aware that this happens, there is still limited understanding of what is actually happening in practice. Using innovation adoption theory, this panel will discuss the issues and challenges surrounding the successful adoption of agile practices. In addition, this panel will report on the obstacles and benefits reported by over 20 industrial partners engaged in a pan-European research project into agile practices between 2006 and 2009.

  12. Distributed Agile Software Development: A Review

    CERN Document Server

    Shrivastava, Suprika Vasudeva

    2010-01-01

    Distribution of software development is becoming more and more common in order to save the production cost and reduce the time to market. Large geographical distance, different time zones and cultural differences in distributed software development (DSD) leads to weak communication which adversely affects the project. Using agile practices for distributed development is also gaining momentum in various organizations to increase the quality and performance of the project. This paper explores the intersection of these two significant trends for software development i.e. DSD and agile. We discuss the challenges faced by geographically distributed agile teams and proven practices to address these issues, which will help in building a successful distributed team.

  13. Developing communications requirements for Agile Product Realization

    Energy Technology Data Exchange (ETDEWEB)

    Forsythe, C.; Ashby, M.R.

    1994-03-01

    Sandia National Laboratories has undertaken the Agile Product Realization for Innovative electroMEchanical Devices (A-PRIMED) pilot project to develop and implement technologies for agile design and manufacturing of electrochemical components. Emphasis on information-driven processes, concurrent engineering and multi-functional team communications makes computer-supported cooperative work critical to achieving significantly faster product development cycles. This report describes analyses conducted in developing communications requirements and a communications plan that addresses the unique communications demands of an agile enterprise.

  14. Social Protocols for Agile Virtual Teams

    Science.gov (United States)

    Picard, Willy

    Despite many works on collaborative networked organizations (CNOs), CSCW, groupware, workflow systems and social networks, computer support for virtual teams is still insufficient, especially support for agility, i.e. the capability of virtual team members to rapidly and cost efficiently adapt the way they interact to changes. In this paper, requirements for computer support for agile virtual teams are presented. Next, an extension of the concept of social protocol is proposed as a novel model supporting agile interactions within virtual teams. The extended concept of social protocol consists of an extended social network and a workflow model.

  15. Social Protocols for Agile Virtual Teams

    CERN Document Server

    Picard, Willy

    2011-01-01

    Despite many works on collaborative networked organizations (CNOs), CSCW, groupware, workflow systems and social networks, computer support for virtual teams is still insufficient, especially support for agility, i.e. the capability of virtual team members to rapidly and cost efficiently adapt the way they interact to changes. In this paper, requirements for computer support for agile virtual teams are presented. Next, an extension of the concept of social protocol is proposed as a novel model supporting agile interactions within virtual teams. The extended concept of social protocol consists of an extended social network and a workflow model.

  16. Variations in Zebra Chip disease expression and tuber biochemistry in response to vector density

    Science.gov (United States)

    This study examined effects of the number of ‘Candidatus Liberibacter solanacearum’ (Lso)-positive psyllids feeding on potatoes to Lso titers, zebra chip disease (ZC) symptom severity, and levels of amino acids, carbohydrates, and phenolics in tubers harvested weeks later. Red La Soda and Russet Nor...

  17. Using the SELDI Protein Chip System to Detect Changes in Protein Expression in Vero Cells after Infection

    Institute of Scientific and Technical Information of China (English)

    Zhi-jun LIU; Bin WANG; Zhi-yong YAN; Xu-xia SONG; Dong-meng QIAN; Zhi-qiang BAI

    2007-01-01

    Human herpes simplex virus 1 (HSV-1) causes facial,ocular,and encephalitic disease and is associated with latent infection and cancer.Here,we developed a means of studying the pathogenesis of HSV-1 infection at the protein level by using the SELDI Protein Chip to detect changes of protein expression in Vero cells cultured in vitro.After infection with HSV-1 and culture for 12,24 or 48 h,cells were harvested and lysed.IMAC3 arrays were applied to SELDI-TOF-MS to detect proteomic differences before and after infection.The chip detected a series of differentially expressed protein peaks.Interestingly,both peaks at 16 912 Da and 17 581 Da corresponded precisely with the molecular mass of ISG 15,which may participate in antiviral activity during the process of infection.Thus,the results we obtained can serve as a basis to study the pathogenesis of HSV-1 and the interaction between the virus and its host.In addition,they can help in the discovery of new therapeutic targets for treatment of HSV-1 infection.

  18. Using enterprise systems to enhance organizational agility

    Directory of Open Access Journals (Sweden)

    Sanjay Mathrani

    Full Text Available In the corporate use of Information and Communication Technology (ICT, deployment of enterprise systems (ESs technology in particular, has been the most vital development towards improving an organization\\'s effectiveness. ESs make up the value chain of an enterprise allowing the organization to become significantly flexible and efficient. This paper investigates the use of ESs to increase agility within three New Zealand manufacturing organizations. Case findings reveal several aspects of ES utilization in agile manufacturing strategies such as concurrent engineering, value chain integration, and creation of virtual enterprise to proactively align work streams and increase responsiveness and flexibility. The paper discusses the importance of agile thinking in business and how an ES enables knowledge-based processes in critical functional areas to improve organizational agility.

  19. Test Methods for Robot Agility in Manufacturing

    Science.gov (United States)

    Downs, Anthony; Harrison, William; Schlenoff, Craig

    2017-01-01

    Purpose The paper aims to define and describe test methods and metrics to assess industrial robot system agility in both simulation and in reality. Design/methodology/approach The paper describes test methods and associated quantitative and qualitative metrics for assessing robot system efficiency and effectiveness which can then be used for the assessment of system agility. Findings The paper describes how the test methods were implemented in a simulation environment and real world environment. It also shows how the metrics are measured and assessed as they would be in a future competition. Practical Implications The test methods described in this paper will push forward the state of the art in software agility for manufacturing robots, allowing small and medium manufacturers to better utilize robotic systems. Originality / value The paper fulfills the identified need for standard test methods to measure and allow for improvement in software agility for manufacturing robots.

  20. Open System of Agile Ground Stations Project

    Data.gov (United States)

    National Aeronautics and Space Administration — There is an opportunity to build the HETE-2/TESS network of ground stations into an innovative and powerful Open System of Agile Stations, by developing a low-cost...

  1. Research on an Agile Manufacturing Information System

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    With the more intense competition in the worldwide market, the agile virtual enterprise (AVE) will become a new organization form of manufacturing enterprise. To support the new rela tionship, an agile manufacturing information system (AMIS) is described in this paper which serves to assist the virtual enterprise to manage and control information flow among collaborating partners. Based on the requirement analysis of virtual information system, the architecture, functions, features and execution scheme of AMIS are discussed in detail.

  2. Leaning Towards Agile in 21~(st) Century

    Institute of Scientific and Technical Information of China (English)

    D; Ashall; B; Parkinson

    2002-01-01

    Background: During the last fifteen years there ha s been an increased drive for organisations to reduce costs. From a production po int, this has often centred on lean manufacturing and JIT waste elimination proc esses. However, in 1991, the Iaccocca Institute Bethlehem P.A commissioned a re port specifically to analyse the changing nature of the marketplace. As a result , in the following year, the Agile Manufacturing Forum was initiated and the ter m 'agile or responsive manufacturing' was first intr...

  3. Is Agile Project Management Applicable to Construction?

    OpenAIRE

    Owen, R.; Koskela, LJ; Henrich, G; Codinhoto, R

    2006-01-01

    This paper briefly summarises the evolution of Agile Project Management (APM) and differentiates it from lean and agile production and ‘leagile’ construction. The significant benefits being realized through employment of APM within the information systems industry are stated. The characteristics of APM are explored, including: philosophy, organizational attitudes and practices, planning, execution and control and learning. Finally, APM is subjectively assessed as to its potential contribution...

  4. The Agile Project Management Mapping Research

    OpenAIRE

    Fang, Aiwen

    2015-01-01

    Purpose: This dissertation reviews the agile project management (APM) related literatures to identify its academic current scenarios. Furthermore, this dissertation also discovers the future research directions of agile project management, especially its application in non-software related industries. Methodology: The literature was planned to be collected through selecting from the journals have 2 to 4* rating in the Association of Business School’s Academic Journal Guide 2015. The appl...

  5. Agility following the application of cold therapy.

    Science.gov (United States)

    Evans, T A; Ingersoll, C; Knight, K L; Worrell, T

    1995-09-01

    Cold application is commonly used before strenuous exercise due to its hypalgesic effects. Some have questioned this procedure because of reports that cold may reduce isokinetic torque. However, there have been no investigations of actual physical performance following cold application. The purpose of this study was to determine if a 20-minute ice immersion treatment to the foot and ankle affected the performance of three agility tests: the carioca maneuver, the cocontraction test, and the shuttle run. Twenty-four male athletic subjects were tested during two different treatment sessions following an orientation session. Subjects were tested following a 20-minute 1 degrees C ice immersion treatment to the dominant foot and ankle and 20 minutes of rest. Following each treatment, subjects performed three trials of each agility test, with 30 seconds rest between each trial, and 1 minute between each different agility test. The order in which each subject performed the agility tests was determined by a balanced Latin square. A MANOVA with repeated measures was used to determine if there was an overall significant difference in the agility times recorded between the cold and control treatments and if the order of the treatment sessions affected the scores. Although the mean agility time scores were slightly slower following the cold treatment, cooling the foot and ankle caused no difference in agility times. Also, there was no difference resulting from the treatment orders. We felt that the slightly slower scores may have been a result of tissue stiffness and/or subject's apprehension immediately following the cold treatment. Cold application to the foot and ankle can be used before strenuous exercise without altering agility.

  6. SOME ASPECTS OF AGILE APPROACH IN PRAXIS

    Directory of Open Access Journals (Sweden)

    Jaroslava Kniežová

    2015-09-01

    Full Text Available In modern times, competitiveness in the market depends on having a good information system. The companies developing and supplying information systems are in competition too, and having an effective system of delivery is critical for obtaining lucrative offers. Therefore, the software development companies continuously try to improve their development process to supply the product in a short time and with high quality. The agile approach potentially shortens this time and is very often used. This approach has almost replaced the traditional process. More and more companies implement agile approach in these times to be competitive in the software development market and hasten product delivering.The traditional and agile approaches differ in certain perspectives. Hence, the question arises as to whether the agile approach is the best for the software development company in every case. This article contains a comparison of these two approaches, as well as a case study relating to the agile approach in a real software development company, which had previously used the traditional approach. The article also describes situation where replacing the traditional approach with agile would improve results.

  7. Agile-based competence management: the relation between agile manufacturing and time-based competence management

    NARCIS (Netherlands)

    Assen, van Marcel F.

    2000-01-01

    Agile manufacturing is largely dependent on the capabilities of its people to learn and evolve with change. However, while agile manufacturing uses e-commerce enabled technology in a decentralized organizational setting, it remains unclear how these individual capabilities should be linked to other

  8. Software ``Best'' Practices: Agile Deconstructed

    Science.gov (United States)

    Fraser, Steven

    Software “best” practices depend entirely on context - in terms of the problem domain, the system constructed, the software designers, and the “customers” ultimately deriving value from the system. Agile practices no longer have the luxury of “choosing” small non-mission critical projects with co-located teams. Project stakeholders are selecting and adapting practices based on a combina tion of interest, need and staffing. For example, growing product portfolios through a merger or the acquisition of a company exposes legacy systems to new staff, new software integration challenges, and new ideas. Innovation in communications (tools and processes) to span the growth and contraction of both information and organizations, while managing the adoption of changing software practices, is imperative for success. Traditional web-based tools such as web pages, document libraries, and forums are not suf ficient. A blend of tweeting, blogs, wikis, instant messaging, web-based confer encing, and telepresence creates a new dimension of communication “best” practices.

  9. Visualisation of gene expression data - the GE-biplot, the Chip-plot and the Gene-plot.

    Science.gov (United States)

    Pittelkow, Yvonne E; Wilson, Susan R

    2003-01-01

    Visualisation methods for exploring microarray data are particularly important for gaining insight into data from gene expression experiments, such as those concerned with the development of an understanding of gene function and interactions. Further, good visualisation techniques are useful for outlier detection in microarray data and for aiding biological interpretation of results, as well as for presentation of overall summaries of the data. The biplot is particularly useful for the display of microarray data as both the genes and the chips can be simultaneously plotted. In this paper we describe several ordination techniques suitable for exploring microarray data, and we call these the GE-biplot, the Chip-plot and the Gene-plot. The general method is first evaluated on synthetic data simulated in accord with current biological interpretation of microarray data. Then it is applied to two well-known data sets, namely the colon data of Alon et al. (1999) and the leukaemia data of Golub et al. (1999). The usefulness of the approach for interpreting and comparing different analyses of the same data is demonstrated.

  10. Gene expression profile differences in high and low metastatic human ovarian cancer cell lines by gene chip

    Institute of Scientific and Technical Information of China (English)

    许沈华; 牟瀚舟; 吕桂泉; 朱赤红; 羊正炎; 高永良; 楼洪坤; 刘祥麟; 程勇; 杨文

    2002-01-01

    Objectives To study the difference between gene expressions of high (H0-8910PM) and low (HO-8910) metastatic human ovarian carcinoma cell lines and screen novel associated genes by cDNA microarray. Methods cDNA retro-transcribed from equal quantities of mRNA derived from high and low metastatic tumor cells or normal ovarian tissues were labeled with Cy5 and Cy3 fluorescein as probes. The mixed probe was hybridized with two pieces of BioDoor 4096 double dot human whole gene chip and scanned with a ScanArray 3000 laser scanner. The acquired image was analyzed by ImaGene 3.0 software. Results A total of 355 genes with expression levels more than 3 times larger were found by comparing the HO-8910 cell with normal ovarian epithelial cells. A total of 323 genes with expression levels more than 3 times larger in HO-8910PM cells compared to normal ovarian epithelium cells were also detected. A total of 165 genes whose expression levels were more than two times those of HO-8910PM cells compared to their mother cell line (HO-8910) were detected. Twenty-one genes with expression levels >3 times were found from comparison of these two tumor cell lines.Conclusions cDNA microarray techniques are effective in screening differential gene expression between two human ovarian cancer cell lines (H0-8910PM; HO-8910) and normal ovarian epithelial cells. These genes may be related to the genesis and development of ovarian carcinoma. Analysis of the human ovarian cancer gene expression profile with cDNA microarray may help in gene diagnosis, treatment and prevention.

  11. Agile Supply Chain Reengineering Based on Multi-Objective Global Performance Measurement

    Institute of Scientific and Technical Information of China (English)

    王炬香; 奚立峰; 王安麟; 胡宗武

    2003-01-01

    The process and related technology of agile supply chain reengineering is discussed in this paper. The process of supply chain reengineering is divided into two parts here: structure reengineering and operation strategy reengineering. Multi-agent concept is adopted in the structure reengineering for the convenience of the modeling. Enterprises in the agile supply chain are expressed as corresponding agents with specified characteristics. Cost and response time are adopted as the main objectives of the global supply chain performance measurement. A virtual simplified supply chain is used to illustrate the role of overall supply chain performance measurement in the reengineering process.

  12. Embedding reflection and learning into agile software development

    DEFF Research Database (Denmark)

    Babb, Jeffry; Hoda, Rashina; Nørbjerg, Jacob

    2014-01-01

    The theoretical underpinnings of agile methods emphasize regular reflection as a means to sustainable development pace and continuous learning, but in practice, high iteration pressure can diminish reflection opportunities. The Reflective Agile Learning Model (REALM) combines insights and results...

  13. Results of agile project management implementation in software engineering companies

    Directory of Open Access Journals (Sweden)

    Suetin Sergei

    2016-01-01

    Full Text Available Agile project management methodologies, tools and techniques have been becoming more and more popular among Russian and foreign software companies. Though the agile software project management methodologies appear to be more flexible and sound alternative to traditional project management approaches, the practice of agile project management implementation needs more research. The article presents the research on the practical results of agile project management implementation in Russian software engineering companies. The survey-based study covers 8 companies and 35 their projects managed with the help of agile methodologies. In contrast to some optimistic researchers of agile practices, the research findings show that in the investigated projects agile project management led to the deterioration of cost and schedule performance. However, the quality, both perceived by clients and assessed by internal technical analysts, improved after the implementation of agile software project management practices.

  14. Modeling and Architectural Design in Agile Development Methodologies

    NARCIS (Netherlands)

    Stojanovic, Z.; Dahanayake, A.; Sol, H

    2003-01-01

    Agile Development Methodologies have been designed to address the problem of delivering high-quality software on time under constantly and rapidly changing requirements in business and IT environments. Agile development processes are characterized by extensive coding practice, intensive communicatio

  15. Barriers to Learning in Agile Software Development Projects

    DEFF Research Database (Denmark)

    Babb, Jeffry S.; Hoda, Rashina; Nørbjerg, Jacob

    2013-01-01

    The adoption of agile methods promises many advantages for individual, team, and organizational learning. However, environmental, structural, and organizational/cultural constraints often find teams adapting agile software development methods rather than engaging in full adoption. We present resu...

  16. Real-time Control Mediation in Agile Distributed Software Development

    DEFF Research Database (Denmark)

    Persson, John Stouby; Aaen, Ivan; Mathiassen, Lars

    2008-01-01

    Agile distributed environments pose particular challenges related to control of quality and collaboration in software development. Moreover, while face-to-face interaction is fundamental in agile development, distributed environments must rely extensively on mediated interactions. On this backdro...

  17. Cloud Computing and Agile Organization Development

    Directory of Open Access Journals (Sweden)

    Bogdan GHILIC-MICU

    2014-01-01

    Full Text Available In the 3rd millennium economy, defined by globalization and continuous reduction of natural resources, the economic organization becomes the main actor in the phenomenon of transfor-mation and adaptation to new conditions. Even more, the economic environment, which is closely related to the social environment, undergoes complex metamorphoses, especially in the management area. In this dynamic and complex social and environmental context, the econom-ic organization must possess the ability to adapt, becoming a flexible and agile answer to new market opportunities. Considering the spectacular evolution of information and communica-tions technology, one of the solutions to ensure organization agility is cloud computing. Just like the development of any science requires adaptation to theories and instruments specific to other fields, a cloud computing paradigm for the agile organization must appeal to models from management, cybernetics, mathematics, structuralism and information theory (or information systems theory.

  18. An investigation of fighter aircraft agility

    Science.gov (United States)

    Valasek, John; Downing, David R.

    1993-01-01

    This report attempts to unify in a single document the results of a series of studies on fighter aircraft agility funded by the NASA Ames Research Center, Dryden Flight Research Facility and conducted at the University of Kansas Flight Research Laboratory during the period January 1989 through December 1993. New metrics proposed by pilots and the research community to assess fighter aircraft agility are collected and analyzed. The report develops a framework for understanding the context into which the various proposed fighter agility metrics fit in terms of application and testing. Since new metrics continue to be proposed, this report does not claim to contain every proposed fighter agility metric. Flight test procedures, test constraints, and related criteria are developed. Instrumentation required to quantify agility via flight test is considered, as is the sensitivity of the candidate metrics to deviations from nominal pilot command inputs, which is studied in detail. Instead of supplying specific, detailed conclusions about the relevance or utility of one candidate metric versus another, the authors have attempted to provide sufficient data and analyses for readers to formulate their own conclusions. Readers are therefore ultimately responsible for judging exactly which metrics are 'best' for their particular needs. Additionally, it is not the intent of the authors to suggest combat tactics or other actual operational uses of the results and data in this report. This has been left up to the user community. Twenty of the candidate agility metrics were selected for evaluation with high fidelity, nonlinear, non real-time flight simulation computer programs of the F-5A Freedom Fighter, F-16A Fighting Falcon, F-18A Hornet, and X-29A. The information and data presented on the 20 candidate metrics which were evaluated will assist interested readers in conducting their own extensive investigations. The report provides a definition and analysis of each metric; details

  19. Explaining the Obvious - How Do You Teach Agile?

    Science.gov (United States)

    Lundh, Erik

    Agile is now a hot topic and many organizations decide on adopting “agile” without really knowing how and why. This workshop will explore how fresh and seasoned agile coaches teach traditional and novel agile concepts, by example, with discussions. All participants are invited to show and tell about agile with an audience of peers. It might be the fresh first time with an audience, or golden hits that served you well for years.

  20. Efficient Mechanisms for Task Allocation in Agile Supply Chain Management

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    An agile supply chain can be defined as a dynamic s up ply network of some autonomous or semi-autonomous business entities, which can well adapt to the competitive, cooperative and dynamic market environment Agile supply chain needs quick response ability to the unpredictable and ever-changin g market environment, and the entities in agile supply chain have complex relati onships of competition, cooperation and dynamics, which make agile supply chain management a very complex process that includes a lot ...

  1. An Investigation of Team Effectiveness in Agile Software Development

    OpenAIRE

    Haraldsen, Lars Martin Riiser

    2012-01-01

    Abstract Agile teamwork has been widely used and accepted in today's industry of software development. The methods in agile teamwork claim to improve performance and predictability, and has during the past years become the target for an emerging area of research. The majority of the existing studies concerning agile teamwork mainly focus around eXtreme Programming (XP). Abstract This report is one of few that discuss teamwork in software development having the agile methodology “Scr...

  2. Adapting Configuration Management for Agile Teams Balancing Sustainability and Speed

    CERN Document Server

    Moreira, Mario E

    2009-01-01

    Adapting Configuration Management for Agile Teams provides very tangible approaches on how Configuration Management with its practices and infrastructure can be adapted and managed in order to directly benefit agile teams. Written by Mario E. Moreira, author of Software Configuration Management Implementation Roadmap , columnist for CM Crossroads online community and writer for the Agile Journal, this unique book provides concrete guidance on tailoring CM for Agile projects without sacrificing the principles of Configuration Management.

  3. The gene expression data of Mycobacterium tuberculosis based on Affymetrix gene chips provide insight into regulatory and hypothetical genes

    Directory of Open Access Journals (Sweden)

    Fu-Liu Casey S

    2007-05-01

    Full Text Available Abstract Background Tuberculosis remains a leading infectious disease with global public health threat. Its control and management have been complicated by multi-drug resistance and latent infection, which prompts scientists to find new and more effective drugs. With the completion of the genome sequence of the etiologic bacterium, Mycobacterium tuberculosis, it is now feasible to search for new drug targets by sieving through a large number of gene products and conduct genome-scale experiments based on microarray technology. However, the full potential of genome-wide microarray analysis in configuring interrelationships among all genes in M. tuberculosis has yet to be realized. To date, it is only possible to assign a function to 52% of proteins predicted in the genome. Results We conducted a functional-genomics study using the high-resolution Affymetrix oligonucleotide GeneChip. Approximately one-half of the genes were found to be always expressed, including more than 100 predicted conserved hypotheticals, in the genome of M. tuberculosis during the log phase of in vitro growth. The gene expression profiles were analyzed and visualized through cluster analysis to epitomize the full details of genomic behavior. Broad patterns derived from genome-wide expression experiments in this study have provided insight into the interrelationships among genes in the basic cellular processes of M. tuberculosis. Conclusion Our results have confirmed several known gene clusters in energy production, information pathways, and lipid metabolism, and also hinted at potential roles of hypothetical and regulatory proteins.

  4. AGILITY INDEXES AND APPLICATION OF PRODUCTION PLANNING

    Institute of Scientific and Technical Information of China (English)

    CHEN Zhixiang

    2006-01-01

    The agility of production planning is defined as two characters: synchronization and flexibility. Measurement indexes for evaluating agility are then divided into two dimensions separately. Synchronization includes two horizontal indexes: order lead time ratio and demand fulfilling rate; Two vertical indexes: instruction-reaction cycle time and resource matching rate.Flexibility includes five indexes: scope flexibility, delivery flexibility, variety flexibility, capacity buffer, inventory buffer and modification flexibility. Quantitative formulas for each measurement index are constructed. One application is discussed to illustrate the feasibility and reasonability of the indexes.

  5. Analyzing effective elements in agile supply chain

    Directory of Open Access Journals (Sweden)

    Babak Jamshidi Navid

    2012-01-01

    Full Text Available Agile supply chain plays an important role on having efficient production planning. There are different factors affecting the efficiency of a supply chain and the attempt of this paper is to find the most important elements in agile supply chain. The proposed model of this paper gathers decision makers' opinions and based on DEMATEL technique determines the most important items. The preliminary results of this survey indicate that we could divide the factors into four groups and two elements including automation and utilization of technical tools of relations and information play the most important roles among other factors.

  6. Agile project management managing for success

    CERN Document Server

    Crowder, James A

    2015-01-01

    Management and enables them to deal with the demands and complexities of modern, agile systems/software/hardware development teams. The book examines the project/program manager beyond the concepts of leadership and aims to connect to employees' sense of identity. The text examines human psychological concepts such as "locus of control," which will help the manager understand their team members' view and how best to manage their "world" contributions. The authors cover new management tools and philosophies for agile systems/software/hardware development teams, with a specific focus on how this

  7. Agile project management with GreenHopper 6 blueprints

    CERN Document Server

    Malik, Jaibeer

    2013-01-01

    A step-by-step tutorial-based approach.This book is of great help for agile teams who are already using or planning to use the GreenHopper tooling system to execute agile projects. It suits all roles in an agile project including system administrators, stakeholders, product owners, scrum masters, and team members. Fundamental knowledge of JIRA is essential.

  8. Experiment list: SRX058454 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ody=Flag M2 [200472-21 (Agilent)] http://dbarchive.biosciencedbc.jp/kyushu-u/sacCer3/eachData/bw/SRX058454.b...,57.5,0 GSM711901: SAGA RC ChIP-seq source_name=YMC RC phase || strain=CEN.PK a SPT7-FLAG::Nat || chip antib

  9. SuperAGILE: the hard X-ray Imager for the AGILE space mission

    CERN Document Server

    Feroci, M; Soffitta, P; Del Monte, E; Di Persio, G; Donnarumma, I; Evangelista, Y; Frutti, M; Lapshov, I; Lazzarotto, F; Mastropietro, M; Morelli, E; Pacciani, L; Porrovecchio, G; Rapisarda, M; Rubini, A; Tavani, M; Argan, A

    2007-01-01

    SuperAGILE is a coded mask experiment based on silicon microstrip detectors. It operates in the 15-45 keV nominal energy range, providing crossed one-dimensional images of the X-ray sky with an on-axis angular resolution of 6 arcmin, over a field of view in excess of 1 steradian. It was designed as the hard X-ray monitor of the AGILE space mission, a small satellite of the Italian Space Agency devoted to image the gamma-ray sky in the 30 MeV - 50 GeV energy band. The AGILE mission was launched in a low-earth orbit on 23^{rd} April 2007. In this paper we describe the SuperAGILE experiment, its construction and test processes, and its performance before flight, based on the on-ground test and calibrations.

  10. Legal Knowledge and Agility in Public Administration

    NARCIS (Netherlands)

    A. Boer; T. van Engers

    2013-01-01

    To address agility in public administration, we have developed a knowledge acquisition infrastructure for legal knowledge, based on an implementation-oriented conceptualization of the legal system. Our objective is to reframe legal knowledge as a knowledge source in a design-oriented task ontology,

  11. Agility and adaptive autonomy in networked organizations

    NARCIS (Netherlands)

    Neef, R.M.; Vecht, B. van der

    2010-01-01

    In any multi-actor environment, there is an inevitable trade-off between achieving global coordination of activities and respecting the autonomy of the actors involved. Agile and resilient behavior demands dynamic coordination capabilities, but task and resource allocation quickly becomes challengin

  12. Lean and Agile: An Epistemological Reflection

    Science.gov (United States)

    Browaeys, Marie-Joelle; Fisser, Sandra

    2012-01-01

    Purpose: The aim of the paper is to contribute to the discussion of treating the concepts of lean and agile in isolation or combination by presenting an alternative view from complexity thinking on these concepts, considering an epistemological approach to this topic. Design/methodology/approach: The paper adopts an epistemological approach, using…

  13. SuperAGILE data processing services

    CERN Document Server

    Lazzarotto, F; Del Monte, E; Donnarumma, I; Evangelista, Y; Feroci, M; Lapshov, I; Pacciani, L; Soffitta, P

    2009-01-01

    The SuperAGILE (SA) instrument is a X-ray detector for As- trophysics measurements, part of the Italian AGILE satellite for X-Ray and Gamma-Ray Astronomy launched at 23/04/2007 from India. SuperAGILE is now studying the sky in the 18 - 60 KeV energy band. It is detecting sources with advanced imaging and timing detection and good spectral detection capabilities. Several astrophysical sources has been detected and localized, including Crab, Vela and GX 301-2. The instrument has the skill to resolve correctly sources in a field of view of [-40, +40] degrees interval, with the angular resolution of 6 arcmin, and a spectral analysis with the resolution of 8 keV. Transient events are regularly detected by SA with the aid of its temporal resolution (2 microsec- onds) and using signal coincidence on different portions of the instrument, with confirmation from other observatories. The SA data processing scientic software performing at the AGILE Ground Segment is divided in modules, grouped in a processing pipeline na...

  14. Management of Innovative Projects through Agile Technology

    Directory of Open Access Journals (Sweden)

    Radu Bucea-Manea-Tonis

    2014-09-01

    Full Text Available Because of the globalization and the evolution of internet and technologies, nowadays the innovation is associated with open collaboration conducted by a legal framework. The paper analyses the methods that allow a better management for innovative projects and focuses on agile projects within a technological network.

  15. Humans and Their Impact on Cyber Agility

    Science.gov (United States)

    2012-06-01

    ends. It is a closed circuit. Within C2, the major loop is called the MAPE (Monitor-Assess-Plan-Execute) which is used to create an Air Tasking...overall MAPE process. Some examples of “loops” are: Humans and Their Impact on Cyber Agility    Approved for Public Release; Distribution Unlimited

  16. Agile Information System Supporting Virtual Enterprise Operation

    Institute of Scientific and Technical Information of China (English)

    许青松; 陶丹; 范玉顺

    2001-01-01

    Dynamic collaboration is a relationship of companies working together for mutual benefit to bring acomplementary set of competencies to gain a market opportunity. A mechanism to manage and controlinformation flow among collaborating partners is described in this paper. Analysis of the virtual informationsystem requirements was used to develop an agile manufacturing information system (AMIS) to create, sustainand dissolve a virtual enterprise.``

  17. Adaptive Autonomy for Agile Task Coordination

    NARCIS (Netherlands)

    Neef, R.M.; Vecht, B. van der

    2008-01-01

    Achieving high levels of agility and resilience in upcoming military organizations will require new ways of thinking about command and control. As traditional military organizations are gradually being equipped for new types of network-centric missions, it becomes obvious that we need rethink coordi

  18. PEOPLE FACTORS IN AGILE SOFTWARE DEVELOPMENT AND PROJECT MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Vikash Lalsing

    2012-02-01

    Full Text Available With the increasing popularity of Agile Methods, many software organisations are moving away fromtraditional methods to adopt Agile development methodologies. Instead of being predictive, Agile israther adaptive and people-focussed. It advocates a small and collaborative team that work closelytogether. But team size is a factor that is in turn constrained by people factors. When implementingAgile, these key factors are often overlooked. This study aims at identifying the underlying peoplefactors to consider when adopting Agile for a team to be effective. The method used is the study ofthree different sized Agile teams developing products based on the same technologies and using Scrum.Both objective and subjective measures were used and the results are supported by a survey. Theresults clearly show that for agile methodologies to work well, it is crucial to select the right people forthe right team.

  19. Investigating the strategic antecedents of agility in humanitarian logistics.

    Science.gov (United States)

    L'Hermitte, Cécile; Brooks, Benjamin; Bowles, Marcus; Tatham, Peter H

    2016-12-16

    This study investigates the strategic antecedents of operational agility in humanitarian logistics. It began by identifying the particular actions to be taken at the strategic level of a humanitarian organisation to support field-level agility. Next, quantitative data (n=59) were collected on four strategic-level capabilities (being purposeful, action-focused, collaborative, and learning-oriented) and on operational agility (field responsiveness and flexibility). Using a quantitative analysis, the study tested the relationship between organisational capacity building and operational agility and found that the four strategic-level capabilities are fundamental building blocks of agility. Collectively they account for 52 per cent of the ability of humanitarian logisticians to deal with ongoing changes and disruptions in the field. This study emphasises the need for researchers and practitioners to embrace a broader perspective of agility in humanitarian logistics. In addition, it highlights the inherently strategic nature of agility, the development of which involves focusing simultaneously on multiple drivers.

  20. ChIP-on-chip analysis identifies IL-22 as direct target gene of ectopically expressed FOXP3 transcription factor in human T cells

    Directory of Open Access Journals (Sweden)

    Jeron Andreas

    2012-12-01

    Full Text Available Abstract Background The transcription factor (TF forkhead box P3 (FOXP3 is constitutively expressed at high levels in naturally occurring CD4+CD25+ regulatory T cells (nTregs. It is not only the most accepted marker for that cell population but is also considered lineage determinative. Chromatin immunoprecipitation (ChIP of TFs in combination with genomic tiling microarray analysis (ChIP-on-chip has been shown to be an appropriate tool for identifying FOXP3 transcription factor binding sites (TFBSs on a genome-wide scale. In combination with microarray expression analysis, the ChIP-on-chip technique allows identification of direct FOXP3 target genes. Results ChIP-on-chip analysis of the human FOXP3 expressed in resting and PMA/ionomycin–stimulated Jurkat T cells revealed several thousand putative FOXP3 binding sites and demonstrated the importance of intronic regions for FOXP3 binding. The analysis of expression data showed that the stimulation-dependent down-regulation of IL-22 was correlated with direct FOXP3 binding in the IL-22 promoter region. This association was confirmed by real-time PCR analysis of ChIP-DNA. The corresponding ChIP-region also contained a matching FOXP3 consensus sequence. Conclusions Knowledge of the general distribution patterns of FOXP3 TFBSs in the human genome under resting and activated conditions will contribute to a better understanding of this TF and its influence on direct target genes, as well as its importance for the phenotype and function of Tregs. Moreover, FOXP3-dependent repression of Th17-related IL-22 may be relevant to an understanding of the phenomenon of Treg/Th17 cell plasticity.

  1. Changes in gene expression profiles of the hip joint ligament of patients with ankylosing spondylitis revealed by DNA chip.

    Science.gov (United States)

    Xu, Ling; Sun, Qingwen; Jiang, Songmin; Li, Jia; He, Chongru; Xu, Weidong

    2012-10-01

    To investigate the pathogenesis of abnormal ossification of the hip ligament in patients with ankylosing spondylitis (AS) by comparing gene expression profiles of the hip ligament in patients with AS to those in normal persons using DNA microarray technology, we studied 18 patients with AS (case group) who underwent total hip arthroplasty in our department from March 1, 2009 to January 31, 2010 and compared them with 6 patients with femoral neck fracture (control group) who underwent total hip replacement. We screened the first five patients in each group with the HumanWG-6 v3.0 Expression BeadChip. Compared to the control group, 519 genes in the case group showed statistically significant differences. Among these, there were 238 upregulated genes and 196 downregulated genes. Gene Ontology (GO) classification showed that differential genes in the hip joint ligaments of patients with AS were involved in immunity, cell adhesion, membrane transport, sugar metabolism, polysaccharide synthesis and metabolism, and cell motility. The Kyoto Encyclopedia of Genes and Genomes classification showed that these differential genes were involved in B cell receptor signaling pathways, adherens junction, protein export, fructose and mannose metabolism, T cell receptor signaling pathways, keratin sulfate biosynthesis, N-glycan biosynthesis, and regulation of the actin cytoskeleton. We tested 2 genes from the screened differential genes in 18 case patients and 6 control cases using real-time polymerase chain reaction. The results demonstrated that the expression of the B4GALT3 gene in the case group was 15.32 times higher than that in the control group (P hip joint ligament ossification.

  2. Combining ChIP-chip and expression profiling to model the MoCRZ1 mediated circuit for Ca/calcineurin signaling in the rice blast fungus.

    Directory of Open Access Journals (Sweden)

    Soonok Kim

    2010-05-01

    Full Text Available Significant progress has been made in defining the central signaling networks in many organisms, but collectively we know little about the downstream targets of these networks and the genes they regulate. To reconstruct the regulatory circuit of calcineurin signal transduction via MoCRZ1, a Magnaporthe oryzae C2H2 transcription factor activated by calcineurin dephosphorylation, we used a combined approach of chromatin immunoprecipitation - chip (ChIP-chip, coupled with microarray expression studies. One hundred forty genes were identified as being both a direct target of MoCRZ1 and having expression concurrently differentially regulated in a calcium/calcineurin/MoCRZ1 dependent manner. Highly represented were genes involved in calcium signaling, small molecule transport, ion homeostasis, cell wall synthesis/maintenance, and fungal virulence. Of particular note, genes involved in vesicle mediated secretion necessary for establishing host associations, were also found. MoCRZ1 itself was a target, suggesting a previously unreported autoregulation control point. The data also implicated a previously unreported feedback regulation mechanism of calcineurin activity. We propose that calcium/calcineurin regulated signal transduction circuits controlling development and pathogenicity manifest through multiple layers of regulation. We present results from the ChIP-chip and expression analysis along with a refined model of calcium/calcineurin signaling in this important plant pathogen.

  3. Investigation of Adherence Degree of Agile Requirements Engineering Practices in Non-Agile Software Development Organizations

    Directory of Open Access Journals (Sweden)

    Mennatallah H. Ibrahim

    2015-01-01

    Full Text Available Requirements are critical for the success of software projects. Requirements are practically difficult to produce, as the hardest stage of building a software system is to decide what the system should do. Moreover, requirements errors are expensive to fix in the later phases of the software development life cycle. The rapidly changing business environment is highly challenging traditional Requirements Engineering (RE practices. Most of the software development organizations are working in such dynamic environment, as a result, either by or without their awareness agile methodologies are adopted in various phases of their software development cycles. The aim of this paper is to investigate the adherence degree of agile RE practices in various software development organizations that are classifying themselves as adopting traditional (i.e. non-agile software development methodologies. An approach is proposed for achieving this aim and it is applied on five different projects from four different organizations. The result shows that even the non-agile software development organizations are applying agile RE practices by different adherence degrees.

  4. Lean as Agile methodology – A Study

    Directory of Open Access Journals (Sweden)

    T. Hari Kumar

    2016-05-01

    Full Text Available The Many approaches and methodologies are available in the development of software with error free to its end user by fulfilling the values of stake-holders. Among the available methodologies Agile is a popular methodology which is introduced in 2001. Agile consists of various development processes such as Scrum, XP, Kanban, Lean and others. Among them Lean is one of the methodology in development of software domain which is adapted from Toyota Production System. This paper concentrates on how Lean sustains in the business stagnation because there exists some problems such as missing deadline, over development and ineffective management. Lean is having its own advantages and pitfalls. To overcome the pitfalls of Lean an adaptive approach is needed which may fit with existing industry standards.

  5. Developer Stories: Improving Architecture in Agile Practice

    DEFF Research Database (Denmark)

    Tjørnehøj, Gitte; Jensen, Rolf Njor; Platz, Niels

    2007-01-01

    Within the field of Software Engineering emergence of agile methods has been a hot topic since the late 90s. eXtreme Programming (XP) ([1]) was one of the first agile methods and is one of the most well-known. However research has pointed to weaknesses in XP regarding supporting development...... of viable architectures. To strengthen XP in this regard a new practice: Developer Stories ([2]) was introduced in 2006 - mainly based on a theoretical argumentation. This paper reports from extensive experimentation with, and elaboration of the new practice. Results from this experimentation shows...... that using Developer Stories increases the likelihood of developing a viable architecture through a series of deliberate choices, through creating disciplined and recurring activities that: 1) Facilitate sharing and embodying of knowledge about architectural issues, and 2) heighten visibility of refactorings...

  6. Agility Evaluation of Mass Customization Product Manufacturing

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Mass Customization (MC) is one of the importance en te rprise produces modes in information age progressively. Mass Customization produ ct manufacturing is aimed at the objection of agile responding to customer deman d, market changing and market opportunities to combine with modern management te chnology and advanced manufacture technology, and to use the development model o f design for product family and technology concurrent. Therefore, in the environ ment of market continuing to change with a high spee...

  7. Running an agile software development project

    CERN Document Server

    Holcombe, Mike

    2008-01-01

    A Practical Approach To Building Small To Medium Software Systems For Real Business Clients Based on more than 100 actual commercial projects, this book clearly explains how to run an agile software development project that delivers high-quality, high-value solutions to business clients. It concentrates on the practical, social, business, and management aspects as well as the technical issues involved. Professor Holcombe successfully connects readers with the wave of "Agile 2.0" concepts that take the techniques of agile development and place them in the service of business goals. Since it is widely believed that the use of Windows XP will become much more common in coming years, readers should be armed with cutting-edge knowledge of the latest practices in the field. Further features of the book include: Case studies provide real-world examples and describe how XP was introduced into the environment Analysis is provided to help readers determine which elements of XP are suitable for the unique challenges and...

  8. First GRB detections with the AGILE Minicalorimeter

    Science.gov (United States)

    Marisaldi, M.; Labanti, C.; Fuschino, F.; Galli, M.; Tavani, M.; Bulgarelli, A.; Gianotti, F.; Trifoglio, M.; Argan, A.

    2008-05-01

    The Minicalorimeter (MCAL) onboard the AGILE satellite is a 1400 cm2 scintillation detector sensitive in the energy range 0.3-200 MeV. MCAL works both as a slave of the AGILE Silicon Tracker and as an autonomous detector for transient events (BURST mode). A dedicated onboard Burst Search logic scans BURST mode data in search of count rate increase. Peculiar characteristics of the detector are the high energy spectral coverage and a timing resolution of about 2 microseconds. Even if a trigger is not issued, BURST mode data are used to build a broad band energy spectrum (scientific ratemeters) organized in 11 bands for each of the two MCAL detection planes, with a time resolution of 1 second. After the first engineering commissioning phase, following the AGILE launch on 23rd April 2007, between 22nd June and 5th November 2007 eighteen GRBs were detected offline in the scientific ratemeters data, with a detection rate of about one per week. In this paper the capabilities of the detector will be described and an overview of the first detected GRBs will be given.

  9. Investigation of the effect of ionizing radiation on gene expression variation by the 'DNA chips': feasibility of a biological dosimeter; Etude de l'effet des radiations ionisantes sur la variation d'expression genique par la methode des 'puces a ADN': faisabilite d'un dosimetre biologique

    Energy Technology Data Exchange (ETDEWEB)

    Gruel, G.

    2005-05-25

    After having described the different biological effects of ionizing radiation and the different approaches to biological dosimetry, and introduced 'DNA chips' or DNA micro-arrays, the author reports the characterization of gene expression variations in the response of cells to a gamma irradiation. Both main aspects of the use DNA chips are investigated: fundamental research and diagnosis. This research thesis thus proposes an analysis of the effect of ionizing radiation using DNA chips, notably by comparing gene expression modifications measured in mouse irradiated lung, heart and kidney. It reports a feasibility study of bio-dosimeter based on expression profiles

  10. How Agile Methods Inspire Project Management - The Half Double Initiative

    DEFF Research Database (Denmark)

    Tordrup Heeager, Lise; Svejvig, Per; Schlichter, Bjarne Rerup

    Increased complexity in projects has forced new project management initiatives. In software development several agile methods have emerged and are today highly implemented in practice. Observations of general project management practice show how it has been inspired by agile software development......, but very little research addresses the issue of agile project management. In order to understand and to provide suggestions for future practice on how agility can be incorporated in general project management, this paper provides an analysis which compares ten characteristics of agile software development...... (identified in theory) and the Half Double Methodology developed by the Danish Project Half Double initiative; a Methodology developed with practitioners and tested in seven Danish case companies. The analysis shows how the general project management to a great extent has been inspired by agile methods...

  11. Towards A Broader Adoption of Agile Software Development Methods

    Directory of Open Access Journals (Sweden)

    Abdallah Alashqur

    2016-12-01

    Full Text Available Traditionally, software design and development has been following the engineering approach as exemplified by the waterfall model, where specifications have to be fully detailed and agreed upon prior to starting the software construction process. Agile software development is a relatively new approach in which specifications are allowed to evolve even after the beginning of the development process, among other characteristics. Thus, agile methods provide more flexibility than the waterfall model, which is a very useful feature in many projects. To benefit from the advantages provided by agile methods, the adoption rate of these methods in software development projects can be further encouraged if certain practices and techniques in agile methods are improved. In this paper, an analysis is provided of several practices and techniques that are part of agile methods that may hinder their broader acceptance. Further, solutions are proposed to improve such practices and consequently facilitate a wider adoption rate of agile methods in software development.

  12. Analysis of motion on agile shell-feeding system

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Since cannon drum of agile shell-feeding system rotates frequently and intermittently, its motion must be steady. Outline of driving cam determines the motion of cannon drum, so it is necessary to select the proper outline of cam. Through analysis of parabolic outline and cycloid outline of the cams, the outline that combines the two curves is obtained. According to the demand of production,the value of the outline is revised, and then the method of fitting curve is used to get the expression of the angle of cam and the displacement of the driven part. Through analyzing the motion of the cannon drum, it is suggested that the angle of the cam is proportion to the displacement of the driven part. The cam with the specially derived outline can move steadily.

  13. Study of the Gene Expression Profile of Human Ovarian Carcinoma by a Gene Chip

    Institute of Scientific and Technical Information of China (English)

    Shenhua Xu; Hanzhou Mou; Chihong Zhu; Lijuan Qian; Zhengyan Yang; Ye Ying; Xianglin Liu

    2005-01-01

    OBJECTIVE To study the difference in gene expression between human ovarian carcinoma and normal ovarian tissues, and screen the novel associated genes by cDNA microarrays.METHODS Total RNA from 10 cases of ovarian cancer and from normal ovarian tissues were extracted by a single step method. The cDNA was retro-transcribed from an equal quantity of mRNA derived from the 10 cases of ovarian carcinoma and normal ovarian tissues, followed by labeling the cDNA strands with Cy5 and Cy3 fluorescence as probes. The mixed probes were hybridized with BiostarH 8464 dot human somatic cell genes.Fluorescence signals were assessed by a ScanArray 4000 laser scanner and the images analyzed by Gene Pix Pro 3.0 software with a digital computer.RESULTS By applying the cDNA microarray we found a total of 185 genes for which expression levels differed more than 5 times comparing human ovarian carcinoma with normal ovarian epithelium. Among these genes 86 were up-regulated >5 times and 99 were down regulated <0.2.CONCLUSION The cDNA microarray technique is effective in screening the differential gene expression between human ovarian cancers and normal ovarian epithelium. It is suggested that these genes identified are related to the genesis and development of ovarian carcinoma.

  14. Agile Development & Software Architecture - Crossing the Great Divide

    Science.gov (United States)

    2016-06-07

    Project on “Communicating the Value of Architecting within Agile Development” as well as other activities focusing on architecture within an Agile...Both Agilists and Architects agree that that the structure of a system (i.e., the system’s decomposition into components and component inter...Mellon University Discuss Agile Development and Software Architecture further at SATURN 2010 Keynotes and invited talks Jim Highsmith Architects

  15. Agile Development and Software Architecture: Understanding Scale and Risk

    Science.gov (United States)

    2012-04-26

    describe your development context? 1. We follow one Agile methodology as closely as we can 2. We use a mix of Agile methodologies 3. We mix Agile and non...In a Scrum project environment, the architectural runway may be established during Sprint 0. Sprint 0 might have a longer duration than the rest of...architecture In its simplest instantiation, a Scrum development environment consists of: • a single co-located, cross-functional team • with skills

  16. Applying Adapted Big Five Teamwork Theory to Agile Software Development

    OpenAIRE

    Strode, Diane

    2016-01-01

    Teamwork is a central tenet of agile software development and various teamwork theories partially explain teamwork in that context. Big Five teamwork theory is one of the most influential teamwork theories, but prior research shows that the team leadership concept in this theory it is not applicable to agile software development. This paper applies an adapted form of Big Five teamwork theory to cases of agile software development. Three independent cases were drawn from a single organisation....

  17. Optimising agile development practices for the maintenance operation: nine heuristics

    DEFF Research Database (Denmark)

    Tordrup Heeager, Lise; Rose, Jeremy

    2014-01-01

    is therefore a trivial endeavour - the maintenance operation differs in some important respects from development work. Classical accounts of software maintenance emphasise more traditional software engineering processes, whereas recent research accounts of agile maintenance efforts uncritically focus......Agile methods are widely used and successful in many development situations and beginning to attract attention amongst the software maintenance community – both researchers and practitioners. However, it should not be assumed that implementing a well-known agile method for a maintenance department...

  18. Static Versus Dynamic Stretching Effect on Agility Performance

    OpenAIRE

    Troumbley, Patrick

    2010-01-01

    The purpose of this study was to compare effects of static and dynamic stretching on explosive agility movements, and to examine the effect of the interaction of dynamic and static stretching prior to explosive agility movements. Fourteen men and 10 women performed the different warm-up protocols, including no warm-up (NWU), static stretching (SS), dynamic stretching (DS), and dynamic stretching with static stretching (DS+SS). The T-Drill was used to assess agility. The results indicated n...

  19. Flexible Workflow Management in Agile Supply Chain System

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    With the vehement development of global competition , Agile Supply Chain (ASC) becomes an effective approach that supports dynamic ent erprise alliance and realizes agile manufacturing, as for the enterprises to cap ture market opportunities rapidly and strengthen their anti-risk ability. As Ag ile Supply Chain System (ASCS) is dynamic and distributed, the realization of it 's processes needs to be much flexible. Often in Agile Supply Chain System (ASCS ), there are many dynamic tasks, many changes of the ...

  20. Agility performance in athletes of different sport specializations

    Directory of Open Access Journals (Sweden)

    Erika Zemková

    2014-09-01

    Full Text Available Background: Data on agility skills in different populations using pre-planned, change of direction speed tests have previously been reported. However, there are no available data on the agility times of athletes specializing in different sports obtained from Reactive agility tests. Objective: The study compares agility time in groups of athletes of different sports where agility is one of the limiting factors of performance. Methods: Altogether 282 athletes of 14 sport specializations performed the Agility test. Their task was to touch, as fast as possible, with either the left or the right foot, one of four mats located outside each of the four corners of a 0.8 m square. The mats had to be touched in accordance with the location of a stimulus in one of the corners of a screen. The test consisted of 60 visual stimuli with random generation of their location on the screen and a time of generation of 500 to 2,500 ms. The result was a sum of the 32 best agility times. Results: The Agility test has been found to be sensitive in distinguishing groups of athletes of different sport specializations. Table tennis players, badminton players, fencers, tae-kwon-do competitors and karate competitors showed the best agility times (< 350 ms, followed by ice-hockey, tennis, soccer, volleyball, basketball, and hockeyball players (350-400 ms, then aikidoists (400-450 ms, and finally judoists and wrestlers (450-500 ms. Conclusions: The best agility times are in athletes of racquet sports, followed by competitors of combat sports with reactions to visual stimuli, then players of ball sports, and finally competitors of combat sports with reactions to tactile stimuli. Since this is the first study testing agility skills using the Reactive agility test in athletes of different sport specializations, data obtained can be used for comparison of athletes within particular sports.

  1. Agil IT-udvikling i et lille team, Udvikling og test med Scrum og agile principper

    OpenAIRE

    Pries-Heje, Rasmus; Olsen, Anders

    2015-01-01

    In this Master Thesis we answer the question: How can Scrum be used in a small two person team to develop an IT solution, and through testing ensure that the IT solution is ready for release? To answer this question we first have gathered and summarized state-of-the-art literature about the use of Scrum and other agile techniques in small teams. Further, we have summarized how development and testing should be done in an agile team. Second, we have conducted our own case-study in a small ...

  2. Complete gene expression profiling of Saccharopolyspora erythraea using GeneChip DNA microarrays

    Directory of Open Access Journals (Sweden)

    Bordoni Roberta

    2007-11-01

    Full Text Available Abstract Background The Saccharopolyspora erythraea genome sequence, recently published, presents considerable divergence from those of streptomycetes in gene organization and function, confirming the remarkable potential of S. erythraea for producing many other secondary metabolites in addition to erythromycin. In order to investigate, at whole transcriptome level, how S. erythraea genes are modulated, a DNA microarray was specifically designed and constructed on the S. erythraea strain NRRL 2338 genome sequence, and the expression profiles of 6494 ORFs were monitored during growth in complex liquid medium. Results The transcriptional analysis identified a set of 404 genes, whose transcriptional signals vary during growth and characterize three distinct phases: a rapid growth until 32 h (Phase A; a growth slowdown until 52 h (Phase B; and another rapid growth phase from 56 h to 72 h (Phase C before the cells enter the stationary phase. A non-parametric statistical method, that identifies chromosomal regions with transcriptional imbalances, determined regional organization of transcription along the chromosome, highlighting differences between core and non-core regions, and strand specific patterns of expression. Microarray data were used to characterize the temporal behaviour of major functional classes and of all the gene clusters for secondary metabolism. The results confirmed that the ery cluster is up-regulated during Phase A and identified six additional clusters (for terpenes and non-ribosomal peptides that are clearly regulated in later phases. Conclusion The use of a S. erythraea DNA microarray improved specificity and sensitivity of gene expression analysis, allowing a global and at the same time detailed picture of how S. erythraea genes are modulated. This work underlines the importance of using DNA microarrays, coupled with an exhaustive statistical and bioinformatic analysis of the results, to understand the transcriptional

  3. Agile kaizen managing continuous improvement far beyond retrospectives

    CERN Document Server

    Medinilla, Ángel

    2014-01-01

    Agile teams have been struggling with the concept of continuous improvement since the first Agile frameworks were developed, and still very little has been written about the practice of continuous improvement in Agile environments. Although team retrospectives have been prescribed and some practices have been introduced in order to implement and facilitate them, the truth is that most Agile teams are conducting dull retrospectives that end with a list of things that have been done wrong, just to repeat the same list two weeks later at the next meeting.Instead of listing hundreds of Japanese-la

  4. A Review of Security Integration Technique in Agile Software Development

    Directory of Open Access Journals (Sweden)

    Raja Khaim

    2016-05-01

    Full Text Available Agile software development has gained a lot of popularity in the software industry due to its iterative and incremental approach as well as user involvement. Agile has also been criticized due to lack of its ability to deliver secure software. In this paper, extensive literature has been performed, in order to highlight the existing security issues in agile software development. Majority of challenges reported in literature, occurred due to lack of involvement of security expert. Improving security of a software system without damaging the real essence of Agile can achieved with the continuous involvement of security engineer throughout development lifecycle with its defined role and responsibilities.

  5. SYSTEMATIC REVIEW OF METRICS IN SOFTWARE AGILE PROJECTS

    Directory of Open Access Journals (Sweden)

    Amrita Raj Mukker

    2015-11-01

    Full Text Available This is a review paper in which things discussed would be about the various software metrics and about agile methodology. Nowadays Agile practices are increasing popularity in software development communities. This paper is a summary of the various metrics, agile and agile methodology used in software industries. Further this papers shows how Extreme Programming practices (XP could enhance the development and implementation of a large -scale and geographically distributed systems .Adaptation of Extreme Programming practices in the project has increased the human factor output and its has helped in bringing up promising idea to enhance the conceptualization and implementation as well as future extensions of large scale projects.

  6. Systematic Review of Metrics in Software Agile Projects

    Directory of Open Access Journals (Sweden)

    Amrita Raj Mukker

    2014-02-01

    Full Text Available This is a review paper in which things discussed would be about the various software metrics and about agile methodology. Nowadays Agile practices are increasing popularity in software development communities. This paper is a summary of the various metrics, agile and agile methodology used in software industries. Further this papers shows how Extreme Programming practices (XP could enhance the development and imp lementation of a large -scale and geographically distributed systems .Adaptation of Extreme Programming practices in the project has increased the human factor output and its has helped in bringing up promising idea to enhance the conceptualization and implementation as well as future extensions of large scale projects.

  7. Applying Agile MethodstoWeapon/Weapon-Related Software

    Energy Technology Data Exchange (ETDEWEB)

    Adams, D; Armendariz, M; Blackledge, M; Campbell, F; Cloninger, M; Cox, L; Davis, J; Elliott, M; Granger, K; Hans, S; Kuhn, C; Lackner, M; Loo, P; Matthews, S; Morrell, K; Owens, C; Peercy, D; Pope, G; Quirk, R; Schilling, D; Stewart, A; Tran, A; Ward, R; Williamson, M

    2007-05-02

    This white paper provides information and guidance to the Department of Energy (DOE) sites on Agile software development methods and the impact of their application on weapon/weapon-related software development. The purpose of this white paper is to provide an overview of Agile methods, examine the accepted interpretations/uses/practices of these methodologies, and discuss the applicability of Agile methods with respect to Nuclear Weapons Complex (NWC) Technical Business Practices (TBPs). It also provides recommendations on the application of Agile methods to the development of weapon/weapon-related software.

  8. Research of Agile Supply Chain Management Decision Support System

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Agile Supply Chain Management (ASCM) is an important topic and has received much attention recently.ASCM is a new management technology.Agile Supply Chain Management Decision Support System (ASCM-DSS) is presented.Firstly, agile supply chain management technology is introduced.Secondly a decision support system for agile supply chain management is proposed.Then, the implementation of ASCM-DSS in enterprise is discussed.Finally, a fuzzy intelligence decision-making process in Shanghai Turbine Generator Company (STGC) is described in detail.

  9. Systematic Literature Review of Agile Scalability for Large Scale Projects

    Directory of Open Access Journals (Sweden)

    Hina saeeda

    2015-09-01

    Full Text Available In new methods, “agile” has come out as the top approach in software industry for the development of the soft wares. With different shapes agile is applied for handling the issues such as low cost, tight time to market schedule continuously changing requirements, Communication & Coordination, team size and distributed environment. Agile has proved to be successful in the small and medium size project, however, it have several limitations when applied on large size projects. The purpose of this study is to know agile techniques in detail, finding and highlighting its restrictions for large size projects with the help of systematic literature review. The systematic literature review is going to find answers for the Research questions: 1 How to make agile approaches scalable and adoptable for large projects?2 What are the existing methods, approaches, frameworks and practices support agile process in large scale projects? 3 What are limitations of existing agile approaches, methods, frameworks and practices with reference to large scale projects? This study will identify the current research problems of the agile scalability for large size projects by giving a detail literature review of the identified problems, existed work for providing solution to these problems and will find out limitations of the existing work for covering the identified problems in the agile scalability. All the results gathered will be summarized statistically based on these finding remedial work will be planned in future for handling the identified limitations of agile approaches for large scale projects.

  10. Handling requirements dependencies in agile projects: a focus group with agile software development practitioners

    NARCIS (Netherlands)

    Martakis, Aias; Daneva, Maya; Wieringa, R.J.; Jean-Louis Cavarero, S.; Rolland, C.; Cavarero, J.-L.

    2013-01-01

    Agile practices on requirements dependencies are a relatively unexplored topic in literature. Empirical studies on it are scarce. This research sets out to uncover concepts that practitioners in companies of various sizes across the globe and in various industries, use for dealing with requirements

  11. Agile informatics: application of agile project management to the development of a personal health application.

    Science.gov (United States)

    Chung, Jeanhee; Pankey, Evan; Norris, Ryan J

    2007-10-11

    We describe the application of the Agile method-- a short iteration cycle, user responsive, measurable software development approach-- to the project management of a modular personal health record, iHealthSpace, to be deployed to the patients and providers of a large academic primary care practice.

  12. A Web-based and Grid-enabled dChip version for the analysis of large sets of gene expression data

    Directory of Open Access Journals (Sweden)

    Scaglione Silvia

    2008-11-01

    Full Text Available Abstract Background Microarray techniques are one of the main methods used to investigate thousands of gene expression profiles for enlightening complex biological processes responsible for serious diseases, with a great scientific impact and a wide application area. Several standalone applications had been developed in order to analyze microarray data. Two of the most known free analysis software packages are the R-based Bioconductor and dChip. The part of dChip software concerning the calculation and the analysis of gene expression has been modified to permit its execution on both cluster environments (supercomputers and Grid infrastructures (distributed computing. This work is not aimed at replacing existing tools, but it provides researchers with a method to analyze large datasets without any hardware or software constraints. Results An application able to perform the computation and the analysis of gene expression on large datasets has been developed using algorithms provided by dChip. Different tests have been carried out in order to validate the results and to compare the performances obtained on different infrastructures. Validation tests have been performed using a small dataset related to the comparison of HUVEC (Human Umbilical Vein Endothelial Cells and Fibroblasts, derived from same donors, treated with IFN-α. Moreover performance tests have been executed just to compare performances on different environments using a large dataset including about 1000 samples related to Breast Cancer patients. Conclusion A Grid-enabled software application for the analysis of large Microarray datasets has been proposed. DChip software has been ported on Linux platform and modified, using appropriate parallelization strategies, to permit its execution on both cluster environments and Grid infrastructures. The added value provided by the use of Grid technologies is the possibility to exploit both computational and data Grid infrastructures to analyze

  13. A Framework to Support Agility Strategy Formulation

    Institute of Scientific and Technical Information of China (English)

    Z; Zhang

    2002-01-01

    In the last decade, turbulent times and uncertainti es in the business environment have made ground for a new business era, and "chang e" has become a major characteristic of the new era. This has resulted in tirele ss evolution of business systems and the creation of new manufacturing and manag ement philosophies. Agile Manufacturing (AM) is a step forward in generation of new means for better performance and success of business, and in practice is a s trategic approach to manufacturing by considering ...

  14. Lean Architecture for Agile Software Development

    CERN Document Server

    Coplien, James O

    2010-01-01

    More and more Agile projects are seeking architectural roots as they struggle with complexity and scale - and they're seeking lightweight ways to do it: Still seeking? In this book the authors help you to find your own path; Taking cues from Lean development, they can help steer your project toward practices with longstanding track records; Up-front architecture? Sure. You can deliver an architecture as code that compiles and that concretely guides development without bogging it down in a mass of documents and guesses about the implementation; Documentation? Even a whiteboard diagram, or a CRC

  15. Frequency-agile antennas for wireless communications

    CERN Document Server

    Petosa, Aldo

    2013-01-01

    Mobile data subscriptions are expected to more than double and mobile wireless traffic to increase by more than tenfold over the next few years. Proliferation of smart phones, tablets, and other portable devices are placing greater demands for services such as web browsing, global positioning, video streaming, and video telephony. Many of the proposed solutions to deal with these demands will have a significant impact on antenna designs. Antennas with frequency agility are considered a promising technology to help implement these new solutions.This book provides readers with a sense of the cap

  16. CMMI (registered trademark) or Agile: Why Not Embrace Both!

    Science.gov (United States)

    2008-11-01

    that the SEI acknowledges that “level mania ” and imposing processes is misuse. Agile experts are encouraged to learn more about CMMI, to seek out and...Glazer 2001] Hillel Glazer. “Dispelling the Process Myth: Having a Process Does Not Mean Sacrificing Agility or Creativity .” CrossTalk: The

  17. Value Creation by Agile Projects: Methodology or Mystery?

    NARCIS (Netherlands)

    Racheva, Zornitza; Daneva, Maya; Sikkel, Klaas; Bomarius, Frank; Oivo, Markku; Jaring, Päivi; Abrahamsson, Pekka

    2009-01-01

    Business value is a key concept in agile software development approaches. This paper presents results of a systematic review of literature on how business value is created by agile projects. We found that with very few exceptions, most published studies take the concept of business value for granted

  18. APPROACH METHOD OF CURRENT COMPETITIVE MARKET - AGILE INDUSTRIAL CORPORATION

    Directory of Open Access Journals (Sweden)

    GHERGHEL Sabina

    2015-05-01

    Full Text Available The term “agility” - agile enterprise - was introduced by a group of American researchers led by R.Dove as a result of some studies in a program sponsored by the US government, a program that primarily aimed at exploring the possibilities of making up production systems which could compete with the efficient production system "lean", introduced in most Japanese companies. Researchers involved in this program have formed Agility Forum, which aims to develop the concepts introduced. In 2001 appears the first paper, by R. Dove, entitled “Response Ability - Understanding the Agile Enterprise”, John Wiley and Sons Editors, in which was synthesized the phase of research field. Agility can be defined as “the ability with which an organization manages to develop successfully in a business environment whose changes are unpredictable.” Being agile means to control change, to notice market opportunities and by being continuously innovating, to succed on the market. The purpose of this paper is to support the idea that agility is a feature derived from the design and also to show that by applying the principles of RRS, which characterize agile systems, it is confirmed the fact that any industrial production system which wishes to be agile it should be designed.

  19. Agile manufacturing in Intelligence, Surveillance and Reconnaissance (ISR)

    Science.gov (United States)

    DiPadua, Mark; Dalton, George

    2016-05-01

    The objective of the Agile Manufacturing for Intelligence, Surveillance, and Reconnaissance (AMISR) effort is to research, develop, design and build a prototype multi-intelligence (multi-INT), reconfigurable pod demonstrating benefits of agile manufacturing and a modular open systems approach (MOSA) to make podded intelligence, surveillance, and reconnaissance (ISR) capability more affordable and operationally flexible.

  20. Agile Service Development: A Rule-Based Method Engineering Approach

    NARCIS (Netherlands)

    Hoppenbrouwers, Stijn; Zoet, Martijn; Versendaal, Johan; Weerd, Inge van de

    2011-01-01

    Agile software development has evolved into an increasingly mature software development approach and has been applied successfully in many software vendors’ development departments. In this position paper, we address the broader agile service development. Based on method engineering principles we de

  1. Agile Methods for Open Source Safety-Critical Software.

    Science.gov (United States)

    Gary, Kevin; Enquobahrie, Andinet; Ibanez, Luis; Cheng, Patrick; Yaniv, Ziv; Cleary, Kevin; Kokoori, Shylaja; Muffih, Benjamin; Heidenreich, John

    2011-08-01

    The introduction of software technology in a life-dependent environment requires the development team to execute a process that ensures a high level of software reliability and correctness. Despite their popularity, agile methods are generally assumed to be inappropriate as a process family in these environments due to their lack of emphasis on documentation, traceability, and other formal techniques. Agile methods, notably Scrum, favor empirical process control, or small constant adjustments in a tight feedback loop. This paper challenges the assumption that agile methods are inappropriate for safety-critical software development. Agile methods are flexible enough to encourage the rightamount of ceremony; therefore if safety-critical systems require greater emphasis on activities like formal specification and requirements management, then an agile process will include these as necessary activities. Furthermore, agile methods focus more on continuous process management and code-level quality than classic software engineering process models. We present our experiences on the image-guided surgical toolkit (IGSTK) project as a backdrop. IGSTK is an open source software project employing agile practices since 2004. We started with the assumption that a lighter process is better, focused on evolving code, and only adding process elements as the need arose. IGSTK has been adopted by teaching hospitals and research labs, and used for clinical trials. Agile methods have matured since the academic community suggested they are not suitable for safety-critical systems almost a decade ago, we present our experiences as a case study for renewing the discussion.

  2. Integrated product definition representation for agile numerical control applications

    Energy Technology Data Exchange (ETDEWEB)

    Simons, W.R. Jr.; Brooks, S.L.; Kirk, W.J. III; Brown, C.W.

    1994-11-01

    Realization of agile manufacturing capabilities for a virtual enterprise requires the integration of technology, management, and work force into a coordinated, interdependent system. This paper is focused on technology enabling tools for agile manufacturing within a virtual enterprise specifically relating to Numerical Control (N/C) manufacturing activities and product definition requirements for these activities.

  3. Change factors requiring agility and implications for IT

    NARCIS (Netherlands)

    Oosterhout, van Marcel; Waarts, Eric; Hillegersberg, van Jos

    2006-01-01

    The current highly dynamic business environment requires businesses to be agile. Business agility is the ability to swiftly and easily change businesses and business processes beyond the normal level of flexibility to effectively manage unpredictable external and internal changes. This study reports

  4. Effective Implementation of Agile Practices - Ingenious and Organized Theoretical Framework

    Directory of Open Access Journals (Sweden)

    Veerapaneni Esther Jyothi

    2011-03-01

    Full Text Available Delivering software in traditional ways is challenged by agile software development to provide a very different approach to software development. Agile methods aim at fast, light and efficient than any other vigorous method to develop and support customers business without being chaotic. Agile software development methods claim to be people-oriented rather than process-oriented and adaptive rather than predictive. Solid Determination and Dedicated efforts are required in agile development to overcome the disadvantages of predefined set of steps and changing requirements to see the desirable outcome and to avoid the predictable results. These methods reach the target promptly by linking developers and stakeholders. The focus of this research paper is two fold. The first part is to study different agile methodologies, find out the levelheaded difficulties in agile software development and suggests possible solutions with a collaborative and innovative framework. The second part of the research paper concentrates on the importance of handling traceability in agile software development and finally proposes an ingenious and organized theoretical framework with a systematic approach to agile software development.

  5. Agile Methods: Selected DoD Management and Acquisition Concerns

    Science.gov (United States)

    2011-10-01

    20, 40 or 100 (an adaptation of a Fibonacci series). Other Agile estimation techniques use similar scales. The spacing between the point values is...acquisition life cycle regulations that provides explicit guidance on contents and sequencing of technical milestones in a program using Agile would

  6. A Methodology for assessing Agile Software Development Approaches

    CERN Document Server

    Soundararajan, Shvetha

    2011-01-01

    Agile methods provide an organization or a team the flexibility to adopt a selected subset of principles and practices based on their culture, their values, and the types of systems that they develop. More specifically, every organization or team implements a customized agile method, tailored to better accommodate its needs. However, the extent to which a customized method supports the organizational objectives, or rather the 'goodness' of that method is questionable. Existing agile assessment approaches focus on a comparative analysis, or are limited in scope and application. In this research, we propose a structured, systematic and comprehensive approach to assess the 'goodness' of agile methods. We examine an agile method based on (1) its adequacy, (2) the capability of the organization to support the adopted principles and practices specified by the method, and (3) the method's effectiveness. We propose the Objectives, Principles and Practices (OPP) Framework to guide our assessment. The Framework identif...

  7. MAPPING OF TRADITIONAL SOFTWARE DEVELOPMENT METHODS TO AGILE METHODOLOGY

    Directory of Open Access Journals (Sweden)

    Rashmi Popli

    2013-02-01

    Full Text Available Agility is bringing in responsibility and ownership in individuals, which will eventually bring out effectiveness and efficiency in deliverables. Companies are drifting from traditional Software Development Life Cycle models to Agile Environment for the purpose of attaining quality and for the sake of saving cost and time. In Traditional models, life cycle is properly defined and also phases are elaborated by specifying needed input and output parameters. On the other hand, in Agile environment, phases are specific to methodologies of Agile - Extreme Programming etc. In this paper a common life cycle approach is proposed that is applicable for different kinds of methods. This paper also aims to describe a mapping function for mapping of traditional methods to Agile methods.

  8. AGILE SOFTWARE DEVELOPMENTAN APPROACH TO LIGHT WEIGHT FROM HEAVY WEIGHT

    Directory of Open Access Journals (Sweden)

    Ambily O.A

    2011-01-01

    Full Text Available Today the world is evolving with technological advancements. Similarly information technology does not enjoy solidity. For instance, we see processors getting faster, hard disks becoming compact, bandwidth increasing, operating systems & programming tools evolving and security is increasing as well. These technical changes and deliberate efforts of people swiftly change the expectations of clients. New software development ideas were presented in the form of Agile Manifesto as a counteraction to that of traditional rigorous methods and paradigms. Agile Manifesto consists of four values and twelve principles. Agile means ‘the quality of being agile’ or dexterity in motion. Agile software development is a highly collaborative and evolutionary approach for system development. Agile methods are a group of development approaches to software development. This paper deals with the applicability of light weightdevelopment methods in the field of software engineering and industry.

  9. Improving ISD Agility in Fast-Moving Software Organizations

    DEFF Research Database (Denmark)

    Persson, John Stouby; Nørbjerg, Jacob; Nielsen, Peter Axel

    2016-01-01

    Fast-moving software organizations must respond quickly to changing technological options and market trends while delivering high-quality services at competitive prices. Improving agility of information systems development (ISD) may reconcile these inherent tensions, but previous research...... study on how to improve ISD agility in a fast-moving software organization. The study maps central problems in the ISD management to direct improvements of agility. Our following intervention addressed method improvements in defining types of ISD by customer relations and integrating the method...... with the task management tool used by the organization. The paper discusses how the action research contributes to our understanding of ISD agility in fast-moving software organizations with a framework for mapping and evaluating improvements of agility. The action research specifically points out that project...

  10. Improving ISD Agility in Fast-moving Software Organizations

    DEFF Research Database (Denmark)

    Persson, John Stouby; Nørbjerg, Jacob; Nielsen, Peter Axel

    2016-01-01

    Fast-moving software organizations must respond quickly to changing technological options and mar-ket trends while delivering high-quality services at competitive prices. Improving agility of infor-mation systems development (ISD) may reconcile these inherent tensions, but previous research...... study on how to improve ISD agility in a fast-moving software organization. The study maps central problems in the ISD management to direct improvements of agility. Our following intervention ad-dressed method improvements in defining types of ISD by customer relations and integrating the method...... with the task management tool used by the organization. The paper discusses how the action research contributes to our understanding of ISD agility in fast-moving software organizations with a framework for mapping and evaluating improvements of agility. The action research specifically points out that project...

  11. Combining Agile and Traditional: Customer Communication in Distributed Environment

    Science.gov (United States)

    Korkala, Mikko; Pikkarainen, Minna; Conboy, Kieran

    Distributed development is a radically increasing phenomenon in modern software development environments. At the same time, traditional and agile methodologies and combinations of those are being used in the industry. Agile approaches place a large emphasis on customer communication. However, existing knowledge on customer communication in distributed agile development seems to be lacking. In order to shed light on this topic and provide practical guidelines for companies in distributed agile environments, a qualitative case study was conducted in a large globally distributed software company. The key finding was that it might be difficult for an agile organization to get relevant information from a traditional type of customer organization, even though the customer communication was indicated to be active and utilized via multiple different communication media. Several challenges discussed in this paper referred to "information blackout" indicating the importance of an environment fostering meaningful communication. In order to evaluate if this environment can be created a set of guidelines is proposed.

  12. Analyzing Agile Development – from Waterfall Style to Scrumban

    Directory of Open Access Journals (Sweden)

    Marian STOICA

    2016-01-01

    Full Text Available The spectacular evolution of information and communications technology in the last two decades and the growing obvious chase of utopian maximization of profit by economic organizations have made an impact on various fields, including that of methodological instruments regarding the lifecycle of software development. We will speak about the necessity of organizational ability to adapt to continuously changing market conditions, which leads undoubtedly to acquiring functional flexibility and, in the end, of business agility. Also, the agility of a business (not only in software development is supported by the manifestation of agility on all three architectural levels: business, informational, technological. In this study we aim to identify the elements that impact on agility in developing software products, in a gradual approach, from the traditional waterfall model towards approaches like Scrumban. Additionally, we will understand the social dimension of using agile methodologies in software development projects and the main barriers in adopting such methodologies.

  13. An Agile Method for E-Service Composition

    CERN Document Server

    Fatehi, Pouya

    2012-01-01

    Nowadays, application of Service Oriented Architecture is increasing rapidly; especially since introduction of distributed electronic services on the web. SOA software has a modular manner and works as a collaboration of independent software components. As a result, e-service approach is sufficient for software with independent components, each of which may be developed by a different company. Such software components and their cooperation form a composite service. Agile methodologies are the best candidate for developing small software components. Composite services and its building blocks are small pieces of software, making agile methodology a perfect fit for their development. In this paper, we introduce an agile method for service composition, inspired by agile patterns and practices. Therefore, across the agile manifesto, we can develop low cost, high quality composite services quickly using this method.

  14. An Agile Method for E-Service Composition

    Directory of Open Access Journals (Sweden)

    Pouya Fatehi

    2012-01-01

    Full Text Available Nowadays, application of Service Oriented Architecture is increasing rapidly; especially since introduction of distributed electronic services on the web. SOA software has a modular manner and works as a collaboration of independent software components. As a result, e-service approach is sufficient for software with independent components, each of which may be developed by a different company. Such software components and their cooperation form a composite service. Agile methodologies are the best candidate for developing small software components. Composite services and their building blocks are small pieces of software, making agile methodology a perfect fit for their development. In this paper, we introduce an agile method for service composition, inspired by agile patterns and practices. Therefore, across the agile manifesto, we can develop low cost, high quality composite services quickly using this method.

  15. Challenges and Weaknesses of Agile Method in Enterprise Architecture

    Directory of Open Access Journals (Sweden)

    Zahra Askarinejad Amiri

    2013-01-01

    Full Text Available As Information Technologies (IT grow in complexity and scope, the need for a coherent approach toenterprise wide modelling becomes paramount. Changing is one of the most important challenges thatorganisation encounter. The topic of enterprise architecture has been gaining significant attention fromboth academia and industry due to the inefficiencies of current IT architecture to cope with rapid changesin business environment. Apart from that, Agile is new concept that present in EA recently. It tries to beadaptive with frequently changes which occurred in organisation. There are some agile methodology andmethod with maintain agile manifesto. Briefly they use agile practices in their development such as XP,Scrum and service oriented architecture. Each of them follows some challenges that lead to less usabilityof them in EA. This research intends to identify these challenges and proposed method to improve theusability of agility in enterprise architecture.

  16. AGILE GOVERNANCE IN INFORMATION AND COMMUNICATION TECHNOLOGIES: SHIFTING PARADIGMS

    Directory of Open Access Journals (Sweden)

    Cleyverson Pereira Costa

    2010-08-01

    Full Text Available This paper presents the basis of the Agile Governance in Information and Communication Technology (ICT, which is based on Agile Software Engineering Methodologies principles and values. Its development was done through a systematic review process, supported by Bibliometrics and Scientometrics methods and techniques, where the Critical Success Factors (CSF of ICT Governance projects and the principles of the Agile Manifesto were analyzed. Next, through an inductive approach, focused on the convergence between the concepts involved, it was analyzed how agile principles could help to minimize the gap between ICT and business. Evidences of their occurrence were taken through a Conceptual Survey Research. As a result, the foundations and concepts of Agile Governance in ICT were defined and, finally, the development of a reference model was proposed as a future work.

  17. Analysis of genome-wide gene expression in root of wheat hybrid and its parents using Barley1 GeneChip

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yinhong; NI Zhongfu; YAO Yingyin; ZHAO Jun; SUN Qixin

    2006-01-01

    Previous studies indicated that differential gene expression between hybrids and their parents is responsible for the heterosis. In this paper, we report genome-wide gene expression analysis in roots of a highly heterotic inter-specific hybrid 3338/2463 and its parental inbreds using Barley GeneChip. A total of 1187 genes displayed difference in gene expressions between hybrid 3338/2463 and its parents, and they can be clustered into eight differential expression patterns. Further analysis revealed that among these 1187 genes, 975genes showed high sequence similarity to the GenBank entries, and represented diverse functional categories, such as metabolism, cell growth and maintenance, signal transduction, response to stress, transcription regulation and others. Fourteen genes were selected for RT-PCR analysis and expression patterns of 9 (64.29%) genes were confirmed. Remarkably, 380 differentially expressed genes could be mapped on the Chinese Spring deletion bins, and with the number of genes in seven homoeologous groups being 158, 148, 121, 140,132, 94 and 127 respectively. It is concluded that a combination of systematic identification of differentially expressed genes with comparative mapping would provide further insight into understanding of molecular basis of heterosis.

  18. DNA chip-based expression profile analysis indicates involvement of the phosphatidylinositol signaling pathway in multiple plant responses to hormone and abiotic treatments

    Institute of Scientific and Technical Information of China (English)

    Wen Hui LIN; Rui YE; Hui MA; Zhi Hong XU; Hong Wei XUE

    2004-01-01

    The phosphatidylinositol (PI) metabolic pathway is considered critical in plant responses to many environmental factors,and previous studies have indicated the involvement of multiple PI-related gene families during cellular responses.Through a detailed analysis of the Arabidopsis thaliana genome,82 polypeptides were identified as being involved in PI signaling. These could be grouped into different families including PI synthases (PIS),PI-phosphate kinases (PIPK),phospholipases (PL),inositol polyphosphate phosphatases (IPPase),inositol polyphosphate kinases (IPK),PI transfer proteins and putative inositol polyphosphate receptors. The presence of more than 10 isoforms of PIPK,PLC,PLD and IPPase suggested that these genes might be differentially expressed during plant cellular responses or growth and development. Accordingly,DNA chip technology was employed to study the expression patterns of various isoforms.In total,79 mRNA clones were amplified and used for DNA chip generation. Expression profile analysis was performed using samples that represented multiple tissues or cellular responses. Tested samples included normal leaf,stem and flower tissues,and leaves from plants treated with various hormones (auxin,cytokinin,gibberellin,abscisic acid and brassinosteroid) or environmental factors (temperature,calcium,sodium,drought,salicylic acid and jasmonic acid).Results showed that many PI pathway-related genes were differentially expressed under these experimental conditions.In particular,the different isoforms of each family were specifically expressed in many cases,suggesting their involvement in tissue specificity and cellular responses to environmental conditions. This work provides a starting point for functional studies of the relevant PI-related proteins and may help shed light onto the role of PI pathways in development and cellular responses.

  19. Integration of Genome-Wide Computation DRE Search, AhR ChIP-chip and Gene Expression Analyses of TCDD-Elicited Responses in the Mouse Liver

    Directory of Open Access Journals (Sweden)

    Matthews Jason

    2011-07-01

    Full Text Available Abstract Background The aryl hydrocarbon receptor (AhR is a ligand-activated transcription factor (TF that mediates responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD. Integration of TCDD-induced genome-wide AhR enrichment, differential gene expression and computational dioxin response element (DRE analyses further elucidate the hepatic AhR regulatory network. Results Global ChIP-chip and gene expression analyses were performed on hepatic tissue from immature ovariectomized mice orally gavaged with 30 μg/kg TCDD. ChIP-chip analysis identified 14,446 and 974 AhR enriched regions (1% false discovery rate at 2 and 24 hrs, respectively. Enrichment density was greatest in the proximal promoter, and more specifically, within ± 1.5 kb of a transcriptional start site (TSS. AhR enrichment also occurred distal to a TSS (e.g. intergenic DNA and 3' UTR, extending the potential gene expression regulatory roles of the AhR. Although TF binding site analyses identified over-represented DRE sequences within enriched regions, approximately 50% of all AhR enriched regions lacked a DRE core (5'-GCGTG-3'. Microarray analysis identified 1,896 number of TCDD-responsive genes (|fold change| ≥ 1.5, P1(t > 0.999. Integrating this gene expression data with our ChIP-chip and DRE analyses only identified 625 differentially expressed genes that involved an AhR interaction at a DRE. Functional annotation analysis of differentially regulated genes associated with AhR enrichment identified overrepresented processes related to fatty acid and lipid metabolism and transport, and xenobiotic metabolism, which are consistent with TCDD-elicited steatosis in the mouse liver. Conclusions Details of the AhR regulatory network have been expanded to include AhR-DNA interactions within intragenic and intergenic genomic regions. Moreover, the AhR can interact with DNA independent of a DRE core suggesting there are alternative mechanisms of AhR-mediated gene regulation.

  20. Improvements In Agile Manifesto For Small Software Development Industries

    Directory of Open Access Journals (Sweden)

    Ratnmala Raval,

    2014-04-01

    Full Text Available Now a day’s business environment is much more dynamic, and organizations are constantly changing their software requirements to adjust to the new environment. They also insist on fast delivery of software products as well as for accepting changing requirements. Agile is swift active and quick to respond, and this is what agile software development methodology refers to. Agile methods are much attracted to small projects, but no agile methods workings glowing as a standalone system so some adoption or customization is needed. The paper describes an agile adoption survey for small industries in Gujarat region. The main objective is to find reasons for less agile adoption. The circulated survey results are analyzed thoroughly and discussed to prove the arguments made during the research time and the recommendations are provided to improve appropriate enhance required changes for the agile principles. Finally, these improvements are implemented by various industries and The analysis of the results showed that the improvements used in the aforementioned cases were effective.

  1. Challenges of adopting agile methods in a public organization

    Directory of Open Access Journals (Sweden)

    Jouko Nuottila

    2016-01-01

    Full Text Available Agile development methods are widely used among business enterprises. Since the introduction of the Agile Manifesto in 2001, several agile methods have been implemented, first in single-team set-ups and later in larger multi-team set-ups for complex Information Technology (IT system development. However, the adoption of agile methods has been slow in the public sector. This is also reflected in the academic literature, as there are only a few studies discussing agile adoption in public organizations. This paper contributes to research on the use of agile practices specifically in the context of public organizations, and sheds light on the challenges a public organization may face while adopting these practices. The aim of this paper is to identify and categorize the challenges that may hinder efficient adoption and use of agile methods in public IT projects that include private software vendors. This research is based on a case study of a large governmental office. As a result, this paper presents several categories of identified challenges, the root causes of these challenges, and a discussion of the characteristics of these challenges for the public sector.

  2. 76 FR 59456 - ASGI Agility Income Fund, et al.; Notice of Application

    Science.gov (United States)

    2011-09-26

    ... COMMISSION ASGI Agility Income Fund, et al.; Notice of Application September 19, 2011. AGENCY: Securities and... sales loads (``CDSCs''). Applicants: ASGI Agility Income Fund (``Agility Fund''), ASGI Aurora... investment company registered under the Act. The Agility Fund is organized as a Delaware statutory trust....

  3. Discovering differential protein expression caused by CagA-induced ERK pathway activation in AGS cells using the SELDI-ProteinChip platform

    Institute of Scientific and Technical Information of China (English)

    Zhen Ge; Yong-Liang Zhu; Xian Zhong; Jie-Kai Yu; Shu Zheng

    2008-01-01

    AIM: To identify the protein expression differences related to the CagA-induced ERK pathway activation in AGS cells.METHODS: Human AGS cells transfected with cagA and blank vector were treated with specific mitogen-activated protein kinase kinase (MEK) inhibitor. Total cell proteins were combined by strong anion exchange (SAX2) and weak cation exchange (CM 10) ProteinChip arrays and analyzed using surface-enhanced laser desorption/ ionization time-of-flight mass spectrometry (SELDI-TOF-MS) proteomics technology. Protein expression profiles were compared with those of inhibitor-untreated cagA transfectants. SwissProt/TrEMBL database searching for differentially expressed proteins was carried out using the Tagldent tool with the pI and mass information.RESULTS: When a total of 16 proteins that showed expression differences in inhibitor-untreated cagA transfectants were compared with vector transfectants, three proteins with m/z 4229, 8162 and 9084 were found to have no expression differences after treatment with MEK inhibitor, while the other 13 maintained the same expression differences after inhibitor treatment. Seven pieces of meaningful matching information for the three proteins were obtained from database searching.CONCLUSION: Biomarkers with m/z 4229, 8162 and 9084 are ERK1/2 phosphorylation dependent, andtherefore are the downstream molecules of ERK1/2 in the ERK/MAPK signaling pathway. The three biomarkers may be important cancer-associated proteins according to SwissProt/TrEMBL database information.

  4. A lab-on-a-chip system integrating tissue sample preparation and multiplex RT-qPCR for gene expression analysis in point-of-care hepatotoxicity assessment.

    Science.gov (United States)

    Lim, Geok Soon; Chang, Joseph S; Lei, Zhang; Wu, Ruige; Wang, Zhiping; Cui, Kemi; Wong, Stephen

    2015-10-21

    A truly practical lab-on-a-chip (LOC) system for point-of-care testing (POCT) hepatotoxicity assessment necessitates the embodiment of full-automation, ease-of-use and "sample-in-answer-out" diagnostic capabilities. To date, the reported microfluidic devices for POCT hepatotoxicity assessment remain rudimentary as they largely embody only semi-quantitative or single sample/gene detection capabilities. In this paper, we describe, for the first time, an integrated LOC system that is somewhat close to a practical POCT hepatotoxicity assessment device - it embodies both tissue sample preparation and multiplex real-time RT-PCR. It features semi-automation, is relatively easy to use, and has "sample-in-answer-out" capabilities for multiplex gene expression analysis. Our tissue sample preparation module incorporating both a microhomogenizer and surface-treated paramagnetic microbeads yielded high purity mRNA extracts, considerably better than manual means of extraction. A primer preloading surface treatment procedure and the single-loading inlet on our multiplex real-time RT-PCR module simplify off-chip handling procedures for ease-of-use. To demonstrate the efficacy of our LOC system for POCT hepatotoxicity assessment, we perform a preclinical animal study with the administration of cyclophosphamide, followed by gene expression analysis of two critical protein biomarkers for liver function tests, aspartate transaminase (AST) and alanine transaminase (ALT). Our experimental results depict normalized fold changes of 1.62 and 1.31 for AST and ALT, respectively, illustrating up-regulations in their expression levels and hence validating their selection as critical genes of interest. In short, we illustrate the feasibility of multiplex gene expression analysis in an integrated LOC system as a viable POCT means for hepatotoxicity assessment.

  5. Cicada: a Heavy but Agile Flyer

    CERN Document Server

    Gai, Kuo; Wan, Hui; Dong, Haibo

    2011-01-01

    "Cicada: a Heavy but Agile Flyer" is a fluid dynamic video submitted to Gallery of Fluid Motion in APS-DFD 2011. Comparing to other insects, cicadas can generate much higher lift to overcome their large body weight. The hidden mechanism may help in designing a Micro Air Vehicle (MAV) to carry large payloads. However, it is lack of literatures in discussing how cicadas use their wings to accomplish various fights. In this work, a high-speed photogrammetry system and 3D surface reconstruction technology are used to reveal cicada wing kinematics and deformation during a freely forward flight. The aerodynamic performance is studied using in-house immerse boundary method based Computational Fluid Dynamics(CFD) solver.

  6. Frequency-agile dual-comb spectroscopy

    CERN Document Server

    Millot, Guy; Yan, Ming; Hovannysyan, Tatevik; Bendahmane, Abdelkrim; Hänsch, Theodor W; Picqué, Nathalie

    2015-01-01

    We propose a new approach to near-infrared molecular spectroscopy, harnessing advanced concepts of optical telecommunications and supercontinuum photonics. We generate, without mode-locked lasers, two frequency combs of slightly different repetition frequencies and moderate, but rapidly tunable, spectral span. The output of a frequency-agile continuous wave laser is split and sent into two electro-optic intensity modulators. Flat-top low-noise frequency combs are produced by wave-breaking in a nonlinear optical fiber of normal dispersion. With a dual-comb spectrometer, we record Doppler-limited spectra spanning 60 GHz within 13 microseconds and 80-kHz refresh rate, at a tuning speed of 10 nm.s^(-1). The sensitivity for weak absorption is enhanced by a long gas-filled hollow-core fiber.

  7. Adding agility to Enterprise Process and Data Engineering

    Directory of Open Access Journals (Sweden)

    Sergey Zykov

    2016-04-01

    Full Text Available Managing development of large and complex enterprise architectures is a key problem in enterprise engineering. Nowadays one of the breathtaking topics considering enterprise context is real-time system agility. The paper discusses an appropriate general architecture pattern and provides insights how dynamic process management environment could be made. We survey general enterprise software architecture and current agility problems. We introduce a special component called a process knowledge base and justify its crucial role in achieving agility within the enterprise. We study both the architecture of the process knowledge base as well as formal basis for its implementation which relies upon the type theory.

  8. Moving target detection for frequency agility radar by sparse reconstruction

    Science.gov (United States)

    Quan, Yinghui; Li, YaChao; Wu, Yaojun; Ran, Lei; Xing, Mengdao; Liu, Mengqi

    2016-09-01

    Frequency agility radar, with randomly varied carrier frequency from pulse to pulse, exhibits superior performance compared to the conventional fixed carrier frequency pulse-Doppler radar against the electromagnetic interference. A novel moving target detection (MTD) method is proposed for the estimation of the target's velocity of frequency agility radar based on pulses within a coherent processing interval by using sparse reconstruction. Hardware implementation of orthogonal matching pursuit algorithm is executed on Xilinx Virtex-7 Field Programmable Gata Array (FPGA) to perform sparse optimization. Finally, a series of experiments are performed to evaluate the performance of proposed MTD method for frequency agility radar systems.

  9. A Adaptive XP-based approach to Agile Development

    CERN Document Server

    Liao, Gang; Luo, Lian

    2012-01-01

    Software design is gradually becoming open, distributed, pervasive, and connected. It is a sad statistical fact that software projects are scientifically fragile and tend to fail more than other engineering fields. Agile development is a philosophy. And agile methods are processes that support the agile philosophy. XP places a strong emphasis on technical practices in addition to the more common teamwork and structural practices. In this paper, we elaborate how XP practices can be used to thinking, collaborating, releasing, planning, developing. And the state that make your team and organization more successful.

  10. Agile rediscovering values: Similarities to continuous improvement strategies

    Science.gov (United States)

    Díaz de Mera, P.; Arenas, J. M.; González, C.

    2012-04-01

    Research in the late 80's on technological companies that develop products of high value innovation, with sufficient speed and flexibility to adapt quickly to changing market conditions, gave rise to the new set of methodologies known as Agile Management Approach. In the current changing economic scenario, we considered very interesting to study the similarities of these Agile Methodologies with other practices whose effectiveness has been amply demonstrated in both the West and Japan. Strategies such as Kaizen, Lean, World Class Manufacturing, Concurrent Engineering, etc, would be analyzed to check the values they have in common with the Agile Approach.

  11. Toward Agile BI By Using In-Memory Analytics

    Directory of Open Access Journals (Sweden)

    Mihaela MUNTEAN

    2014-01-01

    Full Text Available This paper explores one of the newer technologies related to the field of Business Intelligence: in-memory technology. The new class of in-memory BI tools turns a BI solution into an agile BI solution. Also, the paper focuses on the main data models used by in-memory BI technologies and tries to answer following questions: Which are the main characteristics of an agile data model? And, which is the best data model that can be used for enabling an agile BI solution?

  12. Thinking Outside the Box: Agile Business Models for CNOs

    Science.gov (United States)

    Loss, Leandro; Crave, Servane

    This paper introduces the idea of an agile Business Model for CNOs grounded on a new model of innovation based on the effects of globalization and of Knowledge Economy. The agile Business Model considers the resources that are spread out and available worldwide as well as the need for each customer to receive a unique customer experience. It aims at reinforcing in the context of the Knowledge Economy the different business models approaches developed so far. The paper also identifies the levers and the barriers of Agile Business Models Innovation in CNOs.

  13. Addressing the Barriers to Agile Development in DoD

    Science.gov (United States)

    2015-05-01

    pmodigliani@mitre.org May 2015 Addressing the Barriers to Agile Development in DoD MITRE Defense Agile Acquisition Guide Naval Postgraduate School’s...COVERED 00-00-2015 to 00-00-2015 4. TITLE AND SUBTITLE Addressing the Barriers to Agile Development in DoD 5a. CONTRACT NUMBER 5b. GRANT...NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS

  14. Agile parallel bioinformatics workflow management using Pwrake

    Directory of Open Access Journals (Sweden)

    Tanaka Masahiro

    2011-09-01

    Full Text Available Abstract Background In bioinformatics projects, scientific workflow systems are widely used to manage computational procedures. Full-featured workflow systems have been proposed to fulfil the demand for workflow management. However, such systems tend to be over-weighted for actual bioinformatics practices. We realize that quick deployment of cutting-edge software implementing advanced algorithms and data formats, and continuous adaptation to changes in computational resources and the environment are often prioritized in scientific workflow management. These features have a greater affinity with the agile software development method through iterative development phases after trial and error. Here, we show the application of a scientific workflow system Pwrake to bioinformatics workflows. Pwrake is a parallel workflow extension of Ruby's standard build tool Rake, the flexibility of which has been demonstrated in the astronomy domain. Therefore, we hypothesize that Pwrake also has advantages in actual bioinformatics workflows. Findings We implemented the Pwrake workflows to process next generation sequencing data using the Genomic Analysis Toolkit (GATK and Dindel. GATK and Dindel workflows are typical examples of sequential and parallel workflows, respectively. We found that in practice, actual scientific workflow development iterates over two phases, the workflow definition phase and the parameter adjustment phase. We introduced separate workflow definitions to help focus on each of the two developmental phases, as well as helper methods to simplify the descriptions. This approach increased iterative development efficiency. Moreover, we implemented combined workflows to demonstrate modularity of the GATK and Dindel workflows. Conclusions Pwrake enables agile management of scientific workflows in the bioinformatics domain. The internal domain specific language design built on Ruby gives the flexibility of rakefiles for writing scientific workflows

  15. 2011 Agile (Scrum) Workshop Held in Baltimore, Maryland on November 14-15, 2011

    Science.gov (United States)

    2011-11-15

    Created total system requirements and top-level design upfront for sponsor approval  Used agile methodology know as Scrum during system...Untitled Document 2011agile.html[3/23/2016 10:24:57 AM] Files are in Adobe format. Download the newest version from Adobe. 2011 AGILE ( SCRUM ...2750 HYATT REGENCY BALTIMORE u BALTIMORE, MD EVENT #2750 AGILE ( SCRUM ) WORKSHOP Sponsored by the C4ISR Division of NDIA AGILE ( SCRUM ) WORKSHOP

  16. A Structured Framework for Assessing the "Goodness" of Agile Methods

    CERN Document Server

    Soundararajan, Shvetha

    2010-01-01

    Agile Methods are designed for customization; they offer an organization or a team the flexibility to adopt a set of principles and practices based on their culture and values. While that flexibility is consistent with the agile philosophy, it can lead to the adoption of principles and practices that can be sub-optimal relative to the desired objectives. We question then, how can one determine if adopted practices are "in sync" with the identified principles, and to what extent those principles support organizational objectives? In this research, we focus on assessing the "goodness" of an agile method adopted by an organization based on (1) its adequacy, (2) the capability of the organization to provide the supporting environment to competently implement the method, and (3) its effectiveness. To guide our assessment, we propose the Objectives, Principles and Practices (OPP) framework. The design of the OPP framework revolves around the identification of the agile objectives, principles that support the achiev...

  17. Trust in agile teams in distributed software development

    DEFF Research Database (Denmark)

    Tjørnehøj, Gitte; Fransgård, Mette; Skalkam, Signe

    2012-01-01

    that leads to team success. This article reports from a study of two agile DSD teams with very different organization and collaboration patterns. It addresses the role of trust and distrust in DSD by analyzing how the team members’ trust developed and erode through the lifetime of the two collaborations...... and how management actions influenced this. We find that some agile practice can empower teams to take over responsibility for managing their own trust building and sustaining and that management neglect of trust-building in other situations can hinder the development of beneficial balanced agile DSD......Distributed software development (DSD) is becoming everyday practice in the software market. Difficult challenges and difficulty reaching the expected benefits are well documented. Recently agile software development has become common in DSD, even though important incompatibilities between...

  18. Value Creation by Agile Projects: Methodology or Mystery?

    Science.gov (United States)

    Racheva, Zornitza; Daneva, Maya; Sikkel, Klaas

    Business value is a key concept in agile software development approaches. This paper presents results of a systematic review of literature on how business value is created by agile projects. We found that with very few exceptions, most published studies take the concept of business value for granted and do not state what it means in general as well as in the specific study context. We could find no study which clearly indicates how exactly individual agile practices or groups of those create value and keep accumulating it over time. The key implication for research is that we have an incentive to pursue the study of value creation in agile project by deploying empirical research methods.

  19. Modern Enterprise Systems as Enablers of Agile Development

    Science.gov (United States)

    Fredriksson, Odd; Ljung, Lennart

    Traditional ES technology and traditional project management methods are supporting and matching each other. But they are not supporting the critical success conditions for ES development in an effective way. Although the findings from one case study of a successful modern ES change project is not strong empirical evidence, we carefully propose that the new modern ES technology is supporting and matching agile project management methods. In other words, it provides the required flexibility which makes it possible to put into practice the agile way of running projects, both for the system supplier and for the customer. In addition, we propose that the combination of modern ES technology and agile project management methods are more appropriate for supporting the realization of critical success conditions for ES development. The main purpose of this chapter is to compare critical success conditions for modern enterprise systems development projects with critical success conditions for agile information systems development projects.

  20. THE PERCEPTIONS OF AGILE METHODOLOGY IN SOUTH AFRICA

    Directory of Open Access Journals (Sweden)

    Thierry Mbah Mbelli

    2016-01-01

    Full Text Available Agile methodology was introduced in the mid 90’s while the agile manifesto was adopted in 2001. The rationale behind the introduction of the agile methodology was to uncover better ways of developing software that will meet the user’s expectation in an iterative controlled manner. With technological explosion and rift competition for market share, user experience and satisfaction can only be achieved through proper communication between stakeholders and innovative ways of doing things. Doing things differently is what the agile methodology brought. Despite the existence of this methodology for over 20 years now, South African software industry is only starting to realize its existence with a lot of companies jumping into the bandwagon. This paper presents the results of an empirical research of how the South African software industry perceive the methodology.

  1. Effective Implementation of Agile Practices – Incoordination with Lean Kanban

    Directory of Open Access Journals (Sweden)

    Veerapaneni Esther Jyothi

    2012-01-01

    Full Text Available Increased productivity, return on investment and decreased defect rate are the major concerns in now-a days. Agile software development methodologies are in their way into the software mainstream. Agility created revolution in various fields of software development especially in mobilebased applications and internet-based applications development because of the improved quality of thesoftware product. This research paper is the result of immense research work on the implementation of agile software development in coordination with lean kanban which facilitates continuous improvement.This paper portrays the key practices of iterative agile and lean kanban and also focuses on the approaches that can be considered to reduce the defect rate in the software development and increase the productivity.

  2. Atom chips

    CERN Document Server

    Reichel, Jakob

    2010-01-01

    This book provides a stimulating and multifaceted picture of a rapidly developing field. The first part reviews fundamentals of atom chip research in tutorial style, while subsequent parts focus on the topics of atom-surface interaction, coherence on atom chips, and possible future directions of atom chip research. The articles are written by leading researchers in the field in their characteristic and individual styles.

  3. A Review of Scaling Agile Methods in Large Software Development

    Directory of Open Access Journals (Sweden)

    Mashal Alqudah

    2016-12-01

    Full Text Available Agile methods such as Dynamic Systems Development Method (DSDM, Extreme Programming (XP, SCRUM, Agile Modeling (AM and Crystal Clear enable small teams to execute assigned task at their best. However, larger organizations aim at incorporating more Agile methods owing to the fact that its application is prevalently tailored for small teams. The scope in which large firms are interested will extend the original Agile methods to include larger teams, coordination, communication among teams and customers as well as oversight. Determining particular software method is always challenging for software companies especially when considering start-up, small to medium or large enterprises. Most of large organizations develop large-scale projects by teams of teams or teams of teams of teams. Therefore, most recognized Agile methods or first-generation methods such as XP and SCRUM need to be modified before they are employed in large organizations; which is not an easy task. Accomplishing said task would necessitate large organizations to pick and select from the scaling Agile methods in accommodating a single vision for large and multiple teams. Deciding the right choice requires wholesome understanding of the method including its strengths and weaknesses as well as when and how it makes sense. Therefore, the main aim of this paper is to review the existing literature of the utilized scaling Agile methods by defining, discussing and comparing them. In-depth reviews on the literature were performed to juxtapose the methods in impartial manner. In addition, the content analysis was used to analyse the resultant data. The result indicated that the DAD, LeSS, LeSS huge, SAFe, Spotify, Nexus and RAGE are the adopted scaling Agile methods at large organizations. They seem to be similar but there are discrepancies among them that take the form of team size, training and certification, methods and practices adopted, technical practices required and organizational

  4. Agile Software Development in Defense Acquisition: A Mission Assurance Perspective

    Science.gov (United States)

    2012-03-23

    Process-neutral • Software mission assurance does not assume any particular software development methodology , programming language, or tools • Mission...24 Source: [Guano 2008] ^ AER0SPACE The Life Cycle Perspective of Agile Software Development 26 (A) AEROSPACE Agile Life Cycle Example: Scrum ...Daily Scrum Meeting Monthly Sprint Meeting Scrum is a lean approach to software development - Simple "inspect and adapt management framework

  5. YIP: Generic Environment Models (GEMs) for Agile Marine Autonomy

    Science.gov (United States)

    2013-09-30

    1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. YIP : Generic Environment Models (GEMs) for Agile Marine...2013 2. REPORT TYPE 3. DATES COVERED 00-00-2013 to 00-00-2013 4. TITLE AND SUBTITLE YIP : Generic Environment Models (GEMs) for Agile Marine...2010 ONR YIP Award Sponsor: Office of Naval Research Recipient: Fumin Zhang Institution: Georgia Institute of Technology Award: 2010 Lockheed

  6. A PROPOSED MODEL OF AGILE METHODOLOGY IN SOFTWARE DEVELOPMENT

    OpenAIRE

    Anjali Sharma*, Karambir

    2016-01-01

    Agile Software development has been increasing popularity and replacing the traditional methods of software develop-ment. This paper presents the all neural network techniques including General Regression Neural Networks (GRNN), Prob-abilistic Neural Network (PNN), GMDH Polynomial Neural Network, Cascade correlation neural network and a Machine Learning Technique Random Forest. To achieve better prediction, effort estimation of agile projects we will use Random Forest with Story Points Approa...

  7. Seamless Long Term Learning in Agile Teams for Sustainable Leadership

    CERN Document Server

    Qureshi, M R J

    2012-01-01

    Seamless and continuous support for long term organizational learning needs is essential for long lasting progress of the organization. Agile process model provides an excellent opportunity to cater that specific problem and also helps in motivation, satisfaction, coordination, presentation and technical skills enhancement of agile teams. This long term learning process makes organization to sustain their current successes and lead both organization and team members to successful and dynamic market leaders.

  8. Identification, Characterization, and Evaluation Criteria for Systems Engineering Agile Enablers

    Science.gov (United States)

    2015-01-16

    lifecycle, and the changing economic and political factors that undergird and enable system development. The ultimate result of the process is an evaluation...and political factors that undergird and enable system development. Perhaps one of the most important concepts in Agile SE is the reconciliation and...monitoring communications in social media groups and websites (such as LinkedIn or Facebook groups associated with the Scaled Agile Framework, Lean

  9. Agile Methods in Air Force Sustainment: Status and Outlook

    Science.gov (United States)

    2014-10-01

    using a Fibonacci sequence for relative sizing, and cali- brates the sprint content to the team velocity, where the team skill at delivering story points...this time included in the traditional career field training available to personnel. Personnel have a natural tendency to revert back to what they...indicates that software sustainers, more and more, are leveraging Agile methods. On the surface, this seems like a natural fit: Agile methods tend to time

  10. AGILE Observations of Terrestrial Gamma-Ray Flashes

    CERN Document Server

    Marisaldi, M; Labanti, C; Bulgarelli, A; Gianotti, F; Trifoglio, M; Tavani, M; Argan, A; Del Monte, E; Longo, F; Barbiellini, G; Giuliani, A; Trois, A

    2011-01-01

    The AGILE satellite, operating since mid 2007 and primarily devoted to high-energy astrophysics, is one of the only three currently operating space instruments capable of detecting Terrestrial Gamma-Ray Flashes (TGFs), together with RHESSI and $Fermi$-GBM. Thanks to the AGILE Mini-Calorimeter instrument energy range extended up to 100MeV and its flexible trigger logic on sub-millisecond time scales, AGILE is detecting more than 10 TGFs/month, adding a wealth of observations which pose severe constrains on production models. The main AGILE discoveries in TGF science during two and a half years of observations are the following: 1) the TGF spectrum extends well above 40 MeV, 2) the high energy tail of the TGF spectrum is harder than expected and cannot be easily explained by previous theoretical models, 3) TGFs can be localized from space using high-energy photons detected by the AGILE gamma-ray imaging detector. In this presentation we will describe the characteristics of the 2.5-years AGILE TGF sample, focusi...

  11. The Impact of Agile Approach on Software Engineering Teams

    Directory of Open Access Journals (Sweden)

    Mazni Omar

    2011-01-01

    Full Text Available Problem statement: This study presents the initial findings on the impact of agile approach amongst Software Engineering (SE teams in one computer center in Malaysia. This study revealed that agile approach able to receive positive feedbacks and increase positive affectivity amongst team members during software development projects. Approach: This study used action research approach. Data were collected from four Software Engineering (SE teams who volunteered to participate in this study through a series of interviews, short-term observations and a questionnaire. Positive Affect scale from Positive Affect and Negative Affect Schedule (PANAS questionnaire was used to measure the developers’ state of positive affect during two intervals. Results: These findings found that not agile- XP practices adopted by the developers. This is due to knowledge barriers and organizational culture. However, agile approach induced level of positive affectivity amongst the members during software development process. In addition, agile approach promotes the members to be more active in coordinating and collaborating amongst teams. Conclusion: The findings in this study give an insight towards applying a flexible agile approach to accommodate and suit organizational culture. Effective methodology and organizational culture are important factors that must be considered to produce innovative teams and quality software.

  12. Toward the Integration of Traditional and Agile Approaches

    Directory of Open Access Journals (Sweden)

    Hung-Fu Chang

    2013-03-01

    Full Text Available The agile approach uses continuous delivery, instead of distinct procedure, to work closer with customers and to respond faster requirement changes. All of these are against the traditional plan driven approach. Due to agile method’s characteristics and its success in the real world practices, a number of discussions regarding the differences between agile and traditional approaches emerged recently and many studies intended to integrate both methods to synthesize the benefits from these two sides. However, this type of research often concludes from observations of a development activity or surveys after a project. To provide a more objective supportive evidence of comparing these two approaches, our research analyzes the source codes, logs, and notes. We argue that the agile and traditional approaches share common characteristics, which can be considered as the glue for integrating both methods. In our study, we collect all the submissions from the version control repository, and meeting notes and discussions. By applying our suggested analysis method, we illustrate the shared properties between agile and traditional approaches; thus, different development phases, like implementation and test, can still be identified in agile development history. This result not only provides a positive result for our hypothesis but also offers a suggestion for a better integration.

  13. The Agile Alert System For Gamma-Ray Transients

    CERN Document Server

    Bulgarelli, A; Gianotti, F; Tavani, M; Parmiggiani, N; Fioretti, V; Chen, A W; Vercellone, S; Pittori, C; Verrecchia, F; Lucarelli, F; Santolamazza, P; Fanari, G; Giommi, P; Beneventano, D; Argan, A; Trois, A; Scalise, E; Longo, F; Pellizzoni, A; Pucella, G; Colafrancesco, S; Conforti, V; Tempesta, P; Cerone, M; Sabatini, P; Annoni, G; Valentini, G; Salotti, L

    2014-01-01

    In recent years, a new generation of space missions offered great opportunities of discovery in high-energy astrophysics. In this article we focus on the scientific operations of the Gamma-Ray Imaging Detector (GRID) onboard the AGILE space mission. The AGILE-GRID, sensitive in the energy range of 30 MeV-30 GeV, has detected many gamma-ray transients of galactic and extragalactic origins. This work presents the AGILE innovative approach to fast gamma-ray transient detection, which is a challenging task and a crucial part of the AGILE scientific program. The goals are to describe: (1) the AGILE Gamma-Ray Alert System, (2) a new algorithm for blind search identification of transients within a short processing time, (3) the AGILE procedure for gamma-ray transient alert management, and (4) the likelihood of ratio tests that are necessary to evaluate the post-trial statistical significance of the results. Special algorithms and an optimized sequence of tasks are necessary to reach our goal. Data are automatically ...

  14. The Impact of Cloud Computing on Information Systems Agility

    Directory of Open Access Journals (Sweden)

    Mohamed Sawas

    2015-09-01

    Full Text Available As businesses are encountering frequent harsh economic conditions, concepts such as outsourcing, agile and lean management, change management and cost reduction are constantly gaining more attention. This is because these concepts are all aimed at saving on budgets and facing unexpected changes. Latest technologies like cloud computing promise to turn IT, that has always been viewed as a cost centre, into a source of saving money and driving flexibility and agility to the business. The purpose of this paper is to first compile a set of attributes that govern the agility benefits added to information systems by cloud computing and then develop a survey-based instrument to measure these agility benefits. Our research analysis employs non-probability sampling based on a combination of convenience and judgment. This approach was used to obtain a representative sample of participants from potential companies belonging to various industries such as oil & gas, banking, private, government and semi-governmental organizations. This research will enable decision makers to measure agility enhancements and hence compare the agility of Information Systems before and after deploying cloud computing.

  15. The agile alert system for gamma-ray transients

    Energy Technology Data Exchange (ETDEWEB)

    Bulgarelli, A.; Trifoglio, M.; Gianotti, F.; Fioretti, V. [INAF/IASF-Bologna, Via Gobetti 101, I-40129 Bologna (Italy); Tavani, M.; Argan, A.; Trois, A.; Scalise, E. [INAF/IASF-Roma, Via del Fosso del Cavaliere 100, I-00133 Roma (Italy); Parmiggiani, N.; Beneventano, D. [University of Modena and Reggio Emilia, Dipartimento di Science e Metodi dell' Ingegneria (Italy); Chen, A. W. [INAF/IASF-Milano, Via E. Bassini 15, I-20133 Milano (Italy); Vercellone, S. [School of Physics, University of the Witwatersrand, Johannesburg Wits 2050 (South Africa); Pittori, C.; Verrecchia, F.; Lucarelli, F.; Santolamazza, P.; Fanari, G.; Giommi, P. [INAF/IASF-Palermo, Via U. La Malfa 153, I-90146 Palermo (Italy); Longo, F. [ASI-ASDC, Via G. Galilei, I-00044 Frascati (Roma) (Italy); Pellizzoni, A. [INFN Trieste, I-34127 Trieste (Italy); and others

    2014-01-20

    In recent years, a new generation of space missions has offered great opportunities for discovery in high-energy astrophysics. In this article we focus on the scientific operations of the Gamma-Ray Imaging Detector (GRID) on board the AGILE space mission. AGILE-GRID, sensitive in the energy range of 30 MeV-30 GeV, has detected many γ-ray transients of both galactic and extragalactic origin. This work presents the AGILE innovative approach to fast γ-ray transient detection, which is a challenging task and a crucial part of the AGILE scientific program. The goals are to describe (1) the AGILE Gamma-Ray Alert System, (2) a new algorithm for blind search identification of transients within a short processing time, (3) the AGILE procedure for γ-ray transient alert management, and (4) the likelihood of ratio tests that are necessary to evaluate the post-trial statistical significance of the results. Special algorithms and an optimized sequence of tasks are necessary to reach our goal. Data are automatically analyzed at every orbital downlink by an alert pipeline operating on different timescales. As proper flux thresholds are exceeded, alerts are automatically generated and sent as SMS messages to cellular telephones, via e-mail, and via push notifications from an application for smartphones and tablets. These alerts are crosschecked with the results of two pipelines, and a manual analysis is performed. Being a small scientific-class mission, AGILE is characterized by optimization of both scientific analysis and ground-segment resources. The system is capable of generating alerts within two to three hours of a data downlink, an unprecedented reaction time in γ-ray astrophysics.

  16. The AGILE Alert System for Gamma-Ray Transients

    Science.gov (United States)

    Bulgarelli, A.; Trifoglio, M.; Gianotti, F.; Tavani, M.; Parmiggiani, N.; Fioretti, V.; Chen, A. W.; Vercellone, S.; Pittori, C.; Verrecchia, F.; Lucarelli, F.; Santolamazza, P.; Fanari, G.; Giommi, P.; Beneventano, D.; Argan, A.; Trois, A.; Scalise, E.; Longo, F.; Pellizzoni, A.; Pucella, G.; Colafrancesco, S.; Conforti, V.; Tempesta, P.; Cerone, M.; Sabatini, P.; Annoni, G.; Valentini, G.; Salotti, L.

    2014-01-01

    In recent years, a new generation of space missions has offered great opportunities for discovery in high-energy astrophysics. In this article we focus on the scientific operations of the Gamma-Ray Imaging Detector (GRID) on board the AGILE space mission. AGILE-GRID, sensitive in the energy range of 30 MeV-30 GeV, has detected many γ-ray transients of both galactic and extragalactic origin. This work presents the AGILE innovative approach to fast γ-ray transient detection, which is a challenging task and a crucial part of the AGILE scientific program. The goals are to describe (1) the AGILE Gamma-Ray Alert System, (2) a new algorithm for blind search identification of transients within a short processing time, (3) the AGILE procedure for γ-ray transient alert management, and (4) the likelihood of ratio tests that are necessary to evaluate the post-trial statistical significance of the results. Special algorithms and an optimized sequence of tasks are necessary to reach our goal. Data are automatically analyzed at every orbital downlink by an alert pipeline operating on different timescales. As proper flux thresholds are exceeded, alerts are automatically generated and sent as SMS messages to cellular telephones, via e-mail, and via push notifications from an application for smartphones and tablets. These alerts are crosschecked with the results of two pipelines, and a manual analysis is performed. Being a small scientific-class mission, AGILE is characterized by optimization of both scientific analysis and ground-segment resources. The system is capable of generating alerts within two to three hours of a data downlink, an unprecedented reaction time in γ-ray astrophysics.

  17. SiPaGene: A new repository for instant online retrieval, sharing and meta-analyses of GeneChip® expression data

    Directory of Open Access Journals (Sweden)

    Burmester Gerd-R

    2009-03-01

    Full Text Available Abstract Background Microarray expression profiling is becoming a routine technology for medical research and generates enormous amounts of data. However, reanalysis of public data and comparison with own results is laborious. Although many different tools exist, there is a need for more convenience and online analysis with restriction of access and user specific sharing options. Furthermore, most of the currently existing tools do not use the whole range of statistical power provided by the MAS5.0/GCOS algorithms. Description With a current focus on immunology, infection, inflammation, tissue regeneration and cancer we developed a database platform that can load preprocessed Affymetrix GeneChip expression data for immediate access. Group or subgroup comparisons can be calculated online, retrieved for candidate genes, transcriptional activity in various biological conditions and compared with different experiments. The system is based on Oracle 9i with algorithms in java and graphical user interfaces implemented as java servlets. Signals, detection calls, signal log ratios, change calls and corresponding p-values were calculated with MAS5.0/GCOS algorithms. MIAME information and gene annotations are provided via links to GEO and EntrezGene. Users access via https protocol their own, shared or public data. Sharing is comparison- and user-specific with different levels of rights. Arrays for group comparisons can be selected individually. Twenty-two different group comparison parameters can be applied in user-defined combinations on single or multiple group comparisons. Identified genes can be reviewed online or downloaded. Optimized selection criteria were developed and reliability was demonstrated with the "Latin Square" data set. Currently more than 1,000 arrays, 10,000 pairwise comparisons and 500 group comparisons are presented with public or restricted access by different research networks or individual users. Conclusion SiPaGene is a

  18. State of the Art of Agile Governance: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Alexandre J.H.de O.Luna

    2014-11-01

    Full Text Available Context : Agility at the business level requires Information Technology (IT environment flex ible and customizable, as well as effective and responsive governance in order to deliver value faster, bette r, and cheaper to the business. Objective : To understand better this context, our paper seeks to investigate how the domain of agile governance has evolved, as well as to derive implications for research and practice. Method : We conducted a systematic review about the state of art of the agile governance up to and including 2013. Our search strategy identified 1992 studies in 10 databases, of which 167 had the po tential to answer our research questions. Results : We organized the studies into four major groups: software engineering, enterprise, manufacturing and multidisciplinary; classifying them into 16 emerging categories. As a result, the review provides a convergent definition for agile governance, six meta - principles, and a map of findings organized by topic and classified by relevance and convergence. Conclusion : The found evidence lead us to believe that agile governance is a relatively new, wide and multidisciplinary area focused on organizational performance and compet itiveness that needs to be more intensively studied. Finally, we made improvements and additions to the methodological approach for systematic reviews and qualitative studies.

  19. Creativity in Agile Systems Development: A Literature Review

    Science.gov (United States)

    Conboy, Kieran; Wang, Xiaofeng; Fitzgerald, Brian

    Proponents of agile methods claim that enabling, fostering and driving creativity is the key motivation that differentiates agile methods from their more traditional, beauraucratic counterparts. However, there is very little rigorous research to support this claim. Like most of their predecessors, the development and promotion of these methods has been almost entirely driven by practitioners and consultants, with little objective validation from the research community. This lack of validation is particularly relevant for SMEs, given that many of their project teams typify the environment to which agile methods are most suited i.e. small, co-located teams with diverse, blended skills in unstructured, sometimes even chaotic surroundings. This paper uses creativity theory as a lens to review the current agile method literature to understand exactly how much we know about the extent to which creativity actually occurs in these agile environments. The study reveals many gaps and conflict of opinion in the body of knowledge in its current state and identifies many avenues for further research.

  20. The Southern Argentine Agile Meteor Radar (SAAMER)

    Science.gov (United States)

    Janches, Diego

    2014-11-01

    The Southern Argentina Agile Meteor Radar (SAAMER) is a new generation system deployed in Rio Grande, Tierra del Fuego, Argentina (53 S) in May 2008. SAAMER transmits 10 times more power than regular meteor radars, and uses a newly developed transmitting array, which focuses power upward instead of the traditional single-antenna-all-sky configuration. The system is configured such that the transmitter array can also be utilized as a receiver. The new design greatly increases the sensitivity of the radar enabling the detection of large number of particles at low zenith angles. The more concentrated transmitted power enables additional meteor studies besides those typical of these systems based on the detection of specular reflections, such as routine detections of head echoes and non-specular trails, previously only possible with High Power and Large Aperture radars. In August 2010, SAAMER was upgraded to a system capable to determine meteoroid orbital parameters. This was achieved by adding two remote receiving stations approximately 10 km away from the main site in near perpendicular directions. The upgrade significantly expands the science that is achieved with this new radar enabling us to study the orbital properties of the interplanetary dust environment. Because of the unique geographical location, SAAMER allows for additional inter-hemispheric comparison with measurements from Canadian Meteor Orbit Radar, which is geographically conjugate. Initial surveys show, for example, that SAAMER observes a very strong contribution of the South Toroidal Sporadic meteor source, of which limited observational data is available. In addition, SAAMER offers similar unique capabilities for meteor showers and streams studies given the range of ecliptic latitudes that the system enables detailed study of showers at high southern latitudes (e.g July Phoenicids or Puppids complex). Finally, SAAMER is ideal for the deployment of complementary instrumentation in both, permanent

  1. How Agile Methods Conquers General Project Management - The Project Half Double Initiative

    DEFF Research Database (Denmark)

    Tordrup Heeager, Lise; Svejvig, Per; Schlichter, Bjarne Rerup

    2016-01-01

    Increased complexity in projects has forced new project management initiatives. In software development several agile methods have emerged and methods such as Scrum are today highly implemented in practice. General project management practice has been inspired by agile software development...

  2. Managing agility through service orientation in an open telecommunication value chain

    NARCIS (Netherlands)

    Bastiaansen, H.J.M.; Hermans, P.

    2006-01-01

    Agility is key for telecommunication operators to survive in a deregulated, competitive, and converging telecommunications environment. Openness and reusability have emerged as leading concepts to realize such agility. These concepts have both a business perspective and an operational perspective. H

  3. Modeling of Agile Intelligent Manufacturing-oriented Production Scheduling System

    Institute of Scientific and Technical Information of China (English)

    Zhong-Qi Sheng; Chang-Ping Tang; Ci-Xing Lv

    2010-01-01

    Agile intelligent manufacturing is one of the new manufacturing paradigms that adapt to the fierce globalizing market competition and meet the survival needs of the enterprises, in which the management and control of the production system have surpassed the scope of individual enterprise and embodied some new features including complexity, dynamicity, distributivity, and compatibility. The agile intelligent manufacturing paradigm calls for a production scheduling system that can support the cooperation among various production sectors, the distribution of various resources to achieve rational organization, scheduling and management of production activities. This paper uses multi-agents technology to build an agile intelligent manufacturing-oriented production scheduling system. Using the hybrid modeling method, the resources and functions of production system are encapsulated, and the agent-based production system model is established. A production scheduling-oriented multi-agents architecture is constructed and a multi-agents reference model is given in this paper.

  4. EVALUATION OF THE MOST USED AGILE METHODS (XP, LEAN, SCRUM

    Directory of Open Access Journals (Sweden)

    BODJE N’KAUH NATHAN-REGIS

    2012-01-01

    Full Text Available With the emergence of Agile Software Development technologies, the software community is expecting in a large impact on producing quality. The Agile Software Development ideas were presentedin the form of Agile Manifesto which consists of four values and twelve principles. Toyota System production, set also a series of principles and practices which has lead Toyota Motor Corporationcommonly known simply as Toyota (multinational automaker on the top of the car industry market by achieving a reputation for the production of very high quality vehicles in all countries around the world. The main question that each new technology must pass through with success is: How much it’s worth? This paper propose a model for determining the significance worth of quality into the most used agilemethods (eXtreme programming, Scrum, Lean inspired by the Toyota Production System(TPS.

  5. Agile Development for Service Oriented Business Intelligence Solutions

    Directory of Open Access Journals (Sweden)

    Marinela MIRCEA

    2011-03-01

    Full Text Available Considering the evolution of information and communications technology, the necessity of alignment of public and private sectors to European Union requirements, the current economic crisis, and the global context, all organizations are trying to achieve major changes that would enable them to operate as intelligent organizations. For this purpose, agility and Business Intelligence are seen by most managers as a way to transform their organizations into intelligent organizations. The study highlights the importance of modern approaches (Service Oriented Architecture, Business Process Management, Business Rules, Cloud Computing, Master Data Management in developing agile Business Intelligence solutions. The paper also presents the stages of developing an agile Business Intelligence solution in the case of public procurement.

  6. Onshore and Offshore Outsourcing with Agility: Lessons Learned

    Science.gov (United States)

    Kussmaul, Clifton

    This chapter reflects on case study based an agile distributed project that ran for approximately three years (from spring 2003 to spring 2006). The project involved (a) a customer organization with key personnel distributed across the US, developing an application with rapidly changing requirements; (b) onshore consultants with expertise in project management, development processes, offshoring, and relevant technologies; and (c) an external offsite development team in a CMM-5 organization in southern India. This chapter is based on surveys and discussions with multiple participants. The several years since the project was completed allow greater perspective on both the strengths and weaknesses, since the participants can reflect on the entire life of the project, and compare it to subsequent experiences. Our findings emphasize the potential for agile project management in distributed software development, and the importance of people and interactions, taking many small steps to find and correct errors, and matching the structures of the project and product to support implementation of agility.

  7. Architected Agile Solutions for Software-Reliant Systems

    Science.gov (United States)

    Boehm, Barry; Lane, Jo Ann; Koolmanojwong, Supannika; Turner, Richard

    Systems are becoming increasingly reliant on software due to needs for rapid fielding of “70% capabilities,” interoperability, net-centricity, and rapid adaptation to change. The latter need has led to increased interest in agile methods of software development, in which teams rely on shared tacit interpersonal knowledge rather than explicit documented knowledge. However, such systems often need to be scaled up to higher level of performance and assurance, requiring stronger architectural support. Several organizations have recently transformed themselves by developing successful combinations of agility and architecture that can scale to projects of up to 100 personnel. This chapter identifies a set of key principles for such architected agile solutions for software-reliant systems, provides guidance for how much architecting is enough, and illustrates the key principles with several case studies.

  8. Pathways to agility in the production of neutron generators

    Energy Technology Data Exchange (ETDEWEB)

    Stoltz, R.E. [Sandia National Labs., Livermore, CA (United States); Beavis, L.C.; Cutchen, J.T.; Garcia, P.; Gurule, G.A.; Harris, R.N.; McKey, P.C.; Williams, D.W. [Sandia National Labs., Albuquerque, NM (United States)

    1994-02-01

    This report is the result of a study team commissioned to explore pathways for increased agility in the manufacture of neutron generators. As a part of Sandia`s new responsibility for generator production, the goal of the study was to identify opportunities to reduce costs and increase flexibility in the manufacturing operation. Four parallel approaches (or pathways) were recommended: (1) Know the goal, (2) Use design leverage effectively, (3) Value simplicity, and (4) Configure for flexibility. Agility in neutron generator production can be enhanced if all of these pathways are followed. The key role of the workforce in achieving agility was also noted, with emphasis on ownership, continuous learning, and a supportive environment.

  9. Agile learning for the attention challenge in classrooms

    DEFF Research Database (Denmark)

    Chongtay, Rocio

    2015-01-01

    for the students’ attention and more challenging to engage them in the learning process. This paper presents an instructional design that includes elements from Project-Based Learning (PBL) and Agile methodologies to provide collaborative and practical learning skills during a product development process......-PBL improves the learning experience, which is reflected in a higher attendance rate as well as higher percentage of students passing the course. However possible issues implementing Agile-PBL need to be taken into consideration and are also discussed here, including planning and time constraints in trying...... to provide students with the principles and practice in agile methodology in addition to achieving the course’s learning objectives....

  10. Agile vs Traditional Methodologies in Developing Information Systems

    Directory of Open Access Journals (Sweden)

    Pere Tumbas

    2006-12-01

    Full Text Available After the review of principles and concepts of structural and object-oriented development of information systems, the work points to the elements of agile approaches and gives short description of some selected agile methodologies. After these reviews, their comparision according to criteria is done. The first criterion reviews the volume of methodology in which project management is used in developing information systems The second criterion shows if the processes, defined by methodology, cover appropriate phase of the life cycle. The last criterion shows if methodology iniciates the use of skills and tools in the life cycle phases of developing information systems. Finally, the work compares, according to the key elements of development, traditional (structural and object methodologies with agile methodologies.

  11. Trends and perspectives - An architecture for agile shop floor control systems

    DEFF Research Database (Denmark)

    Langer, Gilad; Alting, Leo

    2001-01-01

    as shop floor control. This paper presents the Holonic Multi-cell Control System (HoMuCS) architecture that allows for design and development of holonic shop floor control systems. The HoMuCS is a shop floor control system which is sometimes referred to as a manufacturing execution system...... that is inherently agile. This agility is achieved through two performance parameters: operational agility, allowing for operational change; and structural agility, allowing for structural changes and reconfiguration....

  12. Adaptation of Agile Project Management Methodology for Project Team

    Directory of Open Access Journals (Sweden)

    Rasnacis Arturs

    2015-12-01

    Full Text Available A project management methodology that defines basic processes, tools, techniques, methods, resources and procedures used to manage a project is necessary for effective and successful IT project management. Each company needs to define its own methodology or adapt some of the existing ones. The purpose of the research is to evaluate the possibilities of adapting IT project development methodology according to the company, company employee characteristics and their mutual relations. The adaptation process will be illustrated with a case study at an IT company in Latvia where the developed methodology is based on Agile Scrum, one of the most widespread Agile methods.

  13. Optimal dispatch strategy for the agile virtual power plant

    DEFF Research Database (Denmark)

    Petersen, Mette Højgaard; Bendtsen, Jan Dimon; Stoustrup, Jakob

    2012-01-01

    attempts to preserve maneuverability (stay agile) rather than optimize performance according to predictions. In this paper the imbalance compensation problem for an Agile Virtual Power Plant is formulated. It is proved formally, that when local units are power and energy constrained integrators a dispatch...... strategy exists, which is optimal regardless of future load/imbalances. The optimal dispatch is obtained at each sample by solving a quadratic program. Finally a simulation example illustrates the optimal dispatch strategy and compares the performance with a (non-optimal) MPC-strategy....

  14. Dynamic Organization and Methodology for Agile Virtual Enterprises

    Institute of Scientific and Technical Information of China (English)

    徐晓飞; 叶丹; 李全龙; 战德臣

    2000-01-01

    With the trend of the worldwide market competition, the global agile manufacturing will become an advanced manufacturing technology in 21st cen-tury, and the Agile Virtual Enterprise (AVE) will also become a new organization form of manufacturing enterprises. As AVE is a complicated enterprise, how to build an optimal AVE organization is a difficult problem. In this paper, based on the analysis of the AVE organization, the methodology for AVE including enterprise architecture, reference model, enterprise modeling methods and toolkit, guideline for system implementation is proposed. This paper also presents a Virtual Organization Integrated Support Environment (VOISE), which provides the computer-aided support for rapidly building an optimal AVE.

  15. Advances in waveform-agile sensing for tracking

    CERN Document Server

    Sira, Sandeep Prasad

    2009-01-01

    Recent advances in sensor technology and information processing afford a new flexibility in the design of waveforms for agile sensing. Sensors are now developed with the ability to dynamically choose their transmit or receive waveforms in order to optimize an objective cost function. This has exposed a new paradigm of significant performance improvements in active sensing: dynamic waveform adaptation to environment conditions, target structures, or information features. The manuscript provides a review of recent advances in waveform-agile sensing for target tracking applications. A dynamic wav

  16. Towards Comprehensive and Disciplined Change Management Strategy in Agile Transformation Process

    Directory of Open Access Journals (Sweden)

    Taghi Javdani Gandomani

    2013-08-01

    Full Text Available Moving to agile through a well-defined strategy and framework is essential and this socio-technical process should be studied in deep. Advantages and earned values of agile approach in software industry motivate a lot of companies to try to use agile methods in their software product lines. Transformation process to agile methods is not easy and because of its nature, takes a long time. Since agile transformation needs organizational mutation, companies are faced with many challenges during this process. While several studies have been conducted for how to use agile methods, some other studies have focused on finding obstacles in agile adoption process. However, previous studies are valuable, but each of them has focused the change process from a particular perspective. In this study we discuss the dimensions of agile transformation process from a wider perspective. We will show that focusing on agile adoption is not the only master key for success in agile transformation process and we need to define an agile change management strategy for this organizational metamorphosis. This strategy should consider all aspects of changing approach and is underpinning of achievement in agile transformation process through substantive transformation experiences.

  17. Agility in asset management, or: how to be flexible with assets designed for stability

    NARCIS (Netherlands)

    Ruitenburg, R.J.; Braaksma, A.J.J.; Dongen, van L.A.M.

    2016-01-01

    Agility is increasingly important in manufacturing. However, thus far little attention has been paid to the agility of the physical assets used in production, which are typically designed for decades of operation in a stable context. This paper investigates the topic of agile Asset Management using

  18. Taking Advantage of Agile while Minimizing Risk: User Stories and Other Fables

    Science.gov (United States)

    2013-11-20

    Digital Taskboard ’I Story Mapping • Kanban " Collective Code Ownership " Pair Programming u Automated Acceptance Testing v Analog Taskboard w...Carnegie Mellon University Scaling Agile Brings in More Variation Scaled Agile Framework • Kanban , SCRUM, Value Stream Mapping Disciplined Agile

  19. Speed and Agility: How Defense Acquisition Can Enable Innovation

    Science.gov (United States)

    2016-04-30

    enable top talent to prosper. The DoD should restructure programs and portfolios to enable agile and iterative developments, continue partnerships...organizations assess themselves against three key bureaucracy indicators: the number of management layers, percentage of employee time spent on...provides rapid, decentralized decision-making. To balance these delegated authorities, portfolio reviews give executives and stakeholders transparency

  20. Agile manufacturing and technology transfer to industrialising countries

    NARCIS (Netherlands)

    Steenhuis, Harm-Jan; Boer, de Sirp

    2003-01-01

    One of the requirements of agile manufacturing, the necessity to gain flexibility, can be reached by using a supplier network. A possible way to develop a supplier network is by subcontracting to parties in industrialising countries. In most cases, it is necessary to transfer technology. The aircraf

  1. Current State of Agile User-Centered Design: A Survey

    Science.gov (United States)

    Hussain, Zahid; Slany, Wolfgang; Holzinger, Andreas

    Agile software development methods are quite popular nowadays and are being adopted at an increasing rate in the industry every year. However, these methods are still lacking usability awareness in their development lifecycle, and the integration of usability/User-Centered Design (UCD) into agile methods is not adequately addressed. This paper presents the preliminary results of a recently conducted online survey regarding the current state of the integration of agile methods and usability/UCD. A world wide response of 92 practitioners was received. The results show that the majority of practitioners perceive that the integration of agile methods with usability/UCD has added value to their adopted processes and to their teams; has resulted in the improvement of usability and quality of the product developed; and has increased the satisfaction of the end-users of the product developed. The top most used HCI techniques are low-fidelity prototyping, conceptual designs, observational studies of users, usability expert evaluations, field studies, personas, rapid iterative testing, and laboratory usability testing.

  2. Enabling Agility through Coordinating Temporally Constrained Planning Agents

    NARCIS (Netherlands)

    Steenhuisen, J.R.; De Weerdt, M.M.; Witteveen, C.

    2007-01-01

    In crisis response, hierarchical organizations are being replaced by dynamic assemblies of autonomous agents that promise more agility. However, these autonomous agents might cause a decrease in effectiveness when individually constructed plans for moderately-coupled tasks are not jointly feasible.

  3. Network configuration management : paving the way to network agility.

    Energy Technology Data Exchange (ETDEWEB)

    Maestas, Joseph H.

    2007-08-01

    Sandia networks consist of nearly nine hundred routers and switches and nearly one million lines of command code, and each line ideally contributes to the capabilities of the network to convey information from one location to another. Sandia's Cyber Infrastructure Development and Deployment organizations recognize that it is therefore essential to standardize network configurations and enforce conformance to industry best business practices and documented internal configuration standards to provide a network that is agile, adaptable, and highly available. This is especially important in times of constrained budgets as members of the workforce are called upon to improve efficiency, effectiveness, and customer focus. Best business practices recommend using the standardized configurations in the enforcement process so that when root cause analysis results in recommended configuration changes, subsequent configuration auditing will improve compliance to the standard. Ultimately, this minimizes mean time to repair, maintains the network security posture, improves network availability, and enables efficient transition to new technologies. Network standardization brings improved network agility, which in turn enables enterprise agility, because the network touches all facets of corporate business. Improved network agility improves the business enterprise as a whole.

  4. U-CrAc Flexible Interior Doctrine, Agile Learning Environments

    DEFF Research Database (Denmark)

    Poulsen, Søren Bolvig; Rosenstand, Claus Andreas Foss

    2012-01-01

    The research domain of this article is flexible learning environment for immediate use. The research question is: How can the learning environment support an agile learning process? The research contribution of this article is a flexible interior doctrine. The research method is action research...

  5. Tailoring Agility: Promiscuous Pair Story Authoring and Value Calculation

    Science.gov (United States)

    Tendon, Steve

    This chapter describes how a multi-national software organization created a business plan involving business units from eight countries that followed an agile way, after two previously failed attempts with traditional approaches. The case is told by the consultant who initiated implementation of agility into requirements gathering, estimation and planning processes in an international setting. The agile approach was inspired by XP, but then tailored to meet the peculiar requirements. Two innovations were critical. The first innovation was promiscuous pair story authoring, where user stories were written by two people (similarly to pair programming), and the pairing changed very often (as frequently as every 15-20 minutes) to achieve promiscuity and cater for diverse point of views. The second innovation was an economic value evaluation (and not the cost) which was attributed to stories. Continuous recalculation of the financial value of the stories allowed to assess the projects financial return. In this case implementation of agility in the international context allowed the involved team members to reach consensus and unanimity of decisions, vision and purpose.

  6. Agile Bodies: A New Imperative in Neoliberal Governance

    Science.gov (United States)

    Gillies, Donald

    2011-01-01

    Modern business discourse suggests that a key bulwark against market fluctuation and the threat of failure is for organizations to become "agile'", a more dynamic and proactive position than that previously afforded by mere "flexibility". The same idea is also directed at the personal level, it being argued that the…

  7. Impact of Agile Software Development Model on Software Maintainability

    Science.gov (United States)

    Gawali, Ajay R.

    2012-01-01

    Software maintenance and support costs account for up to 60% of the overall software life cycle cost and often burdens tightly budgeted information technology (IT) organizations. Agile software development approach delivers business value early, but implications on software maintainability are still unknown. The purpose of this quantitative study…

  8. A Capstone Course on Agile Software Development Using Scrum

    Science.gov (United States)

    Mahnic, V.

    2012-01-01

    In this paper, an undergraduate capstone course in software engineering is described that not only exposes students to agile software development, but also makes it possible to observe the behavior of developers using Scrum for the first time. The course requires students to work as Scrum Teams, responsible for the implementation of a set of user…

  9. Cloud Computing as an Enabler of Agile Global Software Development

    Directory of Open Access Journals (Sweden)

    Maureen Tanner

    2016-05-01

    Full Text Available Agile global software development (AGSD is an increasingly prevalent software development strategy, as organizations hope to realize the benefits of accessing a larger resource pool of skilled labor, at a potentially reduced cost, while at the same time delivering value incrementally and iteratively. However, the distributed nature of AGSD creates geographic, temporal, socio-cultural distances that challenge collaboration between project stakeholders. The Cloud Computing (CC service models of Infrastructure as a Service (IaaS, Platform as a Service (PaaS, and Software as a Service (SaaS are similar to the aspirant qualities of AGSD as they provide services that are globally accessible, efficient, and stable, with lower predictable operating costs that scale to meet the computational demand. This study focused on the 12 agile principles upon which all agile methodologies are based, therein potentially increasing the potential for the findings to be generalized. Domestication Theory was used to assist in understanding how cloud technologies were appropriated in support of AGSD. The research strategy took the form of case study research. The findings suggest that some of the challenges in applying the agile principles in AGSD may be overcome by using CC.

  10. How Do Real Options Concepts Fit in Agile Requirements Engineering?

    NARCIS (Netherlands)

    Racheva, Zornitza; Daneva, Maya

    2010-01-01

    Agile requirements engineering is driven by creating business value for the client and heavily involves the client in decision-making under uncertainty. Real option thinking seems to be suitable in supporting the client’s decision making process at inter-iteration time. This paper investigates the f

  11. Study on the Agile Virtual Enterprise's Organizing Form and Running Environment

    Institute of Scientific and Technical Information of China (English)

    SUN Ke; CHEN Ju-hong

    2004-01-01

    In this paper,we begin with the swift changes in the knowledge economy time,analyze the implication of the agility,and consider the agile virtual enterprise as the main organizational form for the manufacturing enterprises to realize agility.We classify the agile virtual enterprises into products alliance style and knowledge alliance style,and compares their main features and profit distribution models.As a result,we give four basic structures for the building and running of the agile virtual enterprises.

  12. Chips 2020

    CERN Document Server

    2016-01-01

    The release of this second volume of CHIPS 2020 coincides with the 50th anniversary of Moore’s Law, a critical year marked by the end of the nanometer roadmap and by a significantly reduced annual rise in chip performance. At the same time, we are witnessing a data explosion in the Internet, which is consuming 40% more electrical power every year, leading to fears of a major blackout of the Internet by 2020. The messages of the first CHIPS 2020, published in 2012, concerned the realization of quantum steps for improving the energy efficiency of all chip functions. With this second volume, we review these messages and amplify upon the most promising directions: ultra-low-voltage electronics, nanoscale monolithic 3D integration, relevant-data, brain- and human-vision-inspired processing, and energy harvesting for chip autonomy. The team of authors, enlarged by more world leaders in low-power, monolithic 3D, video, and Silicon brains, presents new vistas in nanoelectronics, promising  Moore-like exponential g...

  13. Agile application development for mobile devices. Case study: Mobile taximeter

    Directory of Open Access Journals (Sweden)

    Angélica María Babativa Goyeneche

    2016-10-01

    Full Text Available Context: Globalization has affected all productive sectors and in particular the software industry, which has required the development of new methodologies to suit the speed of the changes and allow quickly build products that meet the requirements of the customers. On the other hand, the GPS technology, 4G connectivity and integration of social networks that have the most current mobile phones have opened a large field of application, particularly in the area of the transport, mobility and citizen complaint, whose development can be successfully addressed through an agile methodology. Method: Agile methodology Scrum was used for the development of a mobile application on the Android operating system and GPS technology, which allows a Bogota taxi user to monitor the route and send a complaint to the social network Twitter in case of nonconformity. Some UML models were used for analysis and design of the application, and a confidence interval was used to validate the results. Results: Prototype of a mobile taximeter developed with an agile methodology that meets quality characteristics, extensibility and maintainability. T-student distribution was used to validate the measurement of the prototype on 50 samples, concluding that the difference between the measurement of a real taximeter and our mobile taximeter is on average 2 units with a standard deviation of 1,39 units. Conclusions: It is shown that with the agile development can be combined with UML modeling tools and statistical validation techniques for quality products that do not violate, but on the contrary, that reaffirm the agile development principles.

  14. Research on Evolutionary Mechanism of Agile Supply Chain Network via Complex Network Theory

    Directory of Open Access Journals (Sweden)

    Nai-Ru Xu

    2016-01-01

    Full Text Available The paper establishes the evolutionary mechanism model of agile supply chain network by means of complex network theory which can be used to describe the growth process of the agile supply chain network and analyze the complexity of the agile supply chain network. After introducing the process and the suitability of taking complex network theory into supply chain network research, the paper applies complex network theory into the agile supply chain network research, analyzes the complexity of agile supply chain network, presents the evolutionary mechanism of agile supply chain network based on complex network theory, and uses Matlab to simulate degree distribution, average path length, clustering coefficient, and node betweenness. Simulation results show that the evolution result displays the scale-free property. It lays the foundations of further research on agile supply chain network based on complex network theory.

  15. Statistical Analyses and Modeling of the Implementation of Agile Manufacturing Tactics in Industrial Firms

    Directory of Open Access Journals (Sweden)

    Mohammad D. AL-Tahat

    2012-01-01

    Full Text Available This paper provides a review and introduction on agile manufacturing. Tactics of agile manufacturing are mapped into different production areas (eight-construct latent: manufacturing equipment and technology, processes technology and know-how, quality and productivity improvement, production planning and control, shop floor management, product design and development, supplier relationship management, and customer relationship management. The implementation level of agile manufacturing tactics is investigated in each area. A structural equation model is proposed. Hypotheses are formulated. Feedback from 456 firms is collected using five-point-Likert-scale questionnaire. Statistical analysis is carried out using IBM SPSS and AMOS. Multicollinearity, content validity, consistency, construct validity, ANOVA analysis, and relationships between agile components are tested. The results of this study prove that the agile manufacturing tactics have positive effect on the overall agility level. This conclusion can be used by manufacturing firms to manage challenges when trying to be agile.

  16. A Mapping Model for Transforming Traditional Software Development Methods to Agile Methodology

    Directory of Open Access Journals (Sweden)

    Rashmi Popli

    2013-07-01

    Full Text Available Agility is bringing in responsibility and ownership in individuals, which will eventually bring outeffectiveness and efficiency in deliverables. Agile model is growing in the market at very good pace.Companies are drifting from traditional Software Development Life Cycle models to Agile Environment forthe purpose of attaining quality and for the sake of saving cost and time. Nimbleness nature of Agile ishelpful in frequent releases so as to satisfy the customer by providing frequent dual feedback. InTraditional models, life cycle is properly defined and also phases are elaborated by specifying needed inputand output parameters. On the other hand, in Agile environment, phases are specific to methodologies ofAgile - Extreme Programming etc. In this paper a common life cycle approach is proposed that isapplicable for different kinds of teams. The paper aims to describe a mapping function for mapping oftraditional methods to Agile method.

  17. Project management the agile way making it work in the enterprise

    CERN Document Server

    Goodpasture, John C

    2016-01-01

    Widely acclaimed as one of the top Agile books and a recommended resource for the PMI-ACP Exam in its first edition, Project Management the Agile Way by popular demand has been updated and redesigned. This second edition is in modular format to facilitate training and advanced course instruction, and provides new coverage of Agile, such as hybrid agile methods, the latest public sector practices, and a chapter dedicated to transitioning to agile. It discusses the "grand bargain" between project management and business, the shift in dominance from plans to product, and from input to output, and introduces new concepts such as return on benefit. Experienced practitioners and students that want to learn how to make agile work effectively in the enterprise should read this book. Individuals preparing for the PMI Agile Certified Practitioner (PMI-ACP) examination, and training providers developing courses, will find this second edition quite helpful.

  18. Organizational Agility and Complex Enterprise System Innovations: A Mixed Methods Study of the Effects of Enterprise Systems on Organizational Agility

    Science.gov (United States)

    Kharabe, Amol T.

    2012-01-01

    Over the last two decades, firms have operated in "increasingly" accelerated "high-velocity" dynamic markets, which require them to become "agile." During the same time frame, firms have increasingly deployed complex enterprise systems--large-scale packaged software "innovations" that integrate and automate…

  19. Towards a Strategic Process Model of Governance for Agile IT Implementation: A Healthcare Information Technology Study in China

    OpenAIRE

    Say Yen Teoh; Xi Chen

    2013-01-01

    To remain competitive in the present dynamic environment, ‘governance for agility’ has become a key solution. Past literature paid little attention to understanding how governance for agility, particularly in regard to the delivery of Information Technology (IT) implementation. Using agile organisation and IT-governance theory as lenses to analyse data from a hospital case study, a strategic process model of governance for agility is empirically derived. This model suggests that agile hea...

  20. Bayesian Modeling of ChIP-chip Data Through a High-Order Ising Model

    KAUST Repository

    Mo, Qianxing

    2010-01-29

    ChIP-chip experiments are procedures that combine chromatin immunoprecipitation (ChIP) and DNA microarray (chip) technology to study a variety of biological problems, including protein-DNA interaction, histone modification, and DNA methylation. The most important feature of ChIP-chip data is that the intensity measurements of probes are spatially correlated because the DNA fragments are hybridized to neighboring probes in the experiments. We propose a simple, but powerful Bayesian hierarchical approach to ChIP-chip data through an Ising model with high-order interactions. The proposed method naturally takes into account the intrinsic spatial structure of the data and can be used to analyze data from multiple platforms with different genomic resolutions. The model parameters are estimated using the Gibbs sampler. The proposed method is illustrated using two publicly available data sets from Affymetrix and Agilent platforms, and compared with three alternative Bayesian methods, namely, Bayesian hierarchical model, hierarchical gamma mixture model, and Tilemap hidden Markov model. The numerical results indicate that the proposed method performs as well as the other three methods for the data from Affymetrix tiling arrays, but significantly outperforms the other three methods for the data from Agilent promoter arrays. In addition, we find that the proposed method has better operating characteristics in terms of sensitivities and false discovery rates under various scenarios. © 2010, The International Biometric Society.

  1. Highly Automated Agile Testing Process: An Industrial Case Study

    Directory of Open Access Journals (Sweden)

    Jarosław Berłowski

    2016-09-01

    Full Text Available This paper presents a description of an agile testing process in a medium size software project that is developed using Scrum. The research methods used is the case study were as follows: surveys, quantifiable project data sources and qualitative project members opinions were used for data collection. Challenges related to the testing process regarding a complex project environment and unscheduled releases were identified. Based on the obtained results, we concluded that the described approach addresses well the aforementioned issues. Therefore, recommendations were made with regard to the employed principles of agility, specifically: continuous integration, responding to change, test automation and test driven development. Furthermore, an efficient testing environment that combines a number of test frameworks (e.g. JUnit, Selenium, Jersey Test with custom-developed simulators is presented.

  2. Public Agility and Change in a Network Environment

    Directory of Open Access Journals (Sweden)

    Tom van Engers

    2011-03-01

    Full Text Available Preparing for change is increasingly core business for governmental organizations. The networked society and the increasing connectedness of governmental organizations have as much impact on the complexity of the change process as the complexities of the corpus of law. Change is not only driven by changes in the law; changes in the organization’s environment often create a need to redesign business processes, reallocate roles and responsibilities, and reorder tasks. Moreover, preparations for change are not limited to the internal processes and systems of these organizations. Propagation of changes to network partners and redesign of network arrangements can be an enormous challenge. In the AGILE project, we develop a design method, distributed service architecture, and supporting tools that enable organizations - administrative and otherwise - to orchestrate their law-based services in a networked environment. This paper explains the Agile approach and describes some of its key principles.

  3. Agile Data Management with the Global Change Information System

    Science.gov (United States)

    Duggan, B.; Aulenbach, S.; Tilmes, C.; Goldstein, J.

    2013-12-01

    We describe experiences applying agile software development techniques to the realm of data management during the development of the Global Change Information System (GCIS), a web service and API for authoritative global change information under development by the US Global Change Research Program. Some of the challenges during system design and implementation have been : (1) balancing the need for a rigorous mechanism for ensuring information quality with the realities of large data sets whose contents are often in flux, (2) utilizing existing data to inform decisions about the scope and nature of new data, and (3) continuously incorporating new knowledge and concepts into a relational data model. The workflow for managing the content of the system has much in common with the development of the system itself. We examine various aspects of agile software development and discuss whether or how we have been able to use them for data curation as well as software development.

  4. Preparing your Offshore Organization for Agility: Experiences in India

    Science.gov (United States)

    Srinivasan, Jayakanth

    Two strategies that have significantly changed the way we conventionally think about managing software development and sustainment are the family of development approaches collectively referred to as agile methods, and the distribution of development efforts on a global scale. When you combine the two strategies, organizations have to address not only the technical challenges that arise from introducing new ways of working, but more importantly have to manage the 'soft' factors that if ignored lead to hard challenges. Using two case studies of distributed agile software development in India we illustrate the areas that organizations need to be aware of when transitioning work to India. The key issues that we emphasize are the need to recruit and retain personnel; the importance of teaching, mentoring and coaching; the need to manage customer expectations; the criticality of well-articulated senior leadership vision and commitment; and the reality of operating in a heterogeneous process environment.

  5. BTT autopilot design for agile missiles with aerodynamic uncer tainty

    Institute of Scientific and Technical Information of China (English)

    Yueyue Ma; Jie Guo; Shengjing Tang

    2015-01-01

    The approach to the synthesis of autopilot with aerody-namic uncertainty is investigated in order to achieve large maneu-verability of agile missiles. The dynamics of the agile missile with reaction-jet control system (RCS) are presented. Subsequently, the cascade control scheme based on the bank-to-turn (BTT) steering technique is described. To address the aerodynamic un-certainties encountered by the control system, the active distur-bance rejection control (ADRC) method is introduced in the autopi-lot design. Furthermore, a compound control er, using extended state observer (ESO) to online estimate system uncertainties and calculate derivative of command signals, is designed based on dynamic surface control (DSC). Nonlinear simulation results show the feasibility of the proposed approach and validate the robust-ness of the control er with severe unmodeled dynamics.

  6. Agile Company Development - Looking for a new concept

    DEFF Research Database (Denmark)

    Andersen, Jesper Rank; Mikkelsen, Hans; Riis, Jens Ove

    2004-01-01

    This paper will explore the concepts of Lean and Agile Thinking to see, if they may enrich the management of internal company development activities. At any point in time, companies have a crowd of development activities spread around the organization and managed at different levels...... in the managerial hierarchy. They compete for resources and managerial attention and they often take too long time – and some do not survive in the rapid changing context. Top managers ask for speed, flexibility and effectiveness. Can the ideas and principles from Agile and Lean Thinking concepts developed...... for manufacturing management, be transformed to the management of internal company development? The paper will discuss this question. Practices observed from empirical studies will demonstrate application of the concepts and will form the basis for developing an appropriate, company-specific blend of methods...

  7. Study on the agile supply chain management based on agent

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The most important task of the agile supply chain management (ASCM) is to reconfigure a supply chain based on the customers' requirement. Without more sophisticated cooperation and dynamic formation in an agile supply chain, it cannot be achieved for mass customization, rapid response and high quality services. Because of its great potential in supporting cooperation for the supply chain management, agent technology can carry out the cooperative work by inter-operation across networked human, organization and machines at the abstractive level in a computational system. A major challenge in building such a system is to coordinate the behavior of individual agent or a group of agents to achieve the individual and shared goals of the participants. In this paper, the agent technology is used to support modeling and coordinating of supply chain management.

  8. Oligomicroarray-based primary study of gene expression profile changes in Barrett's esophagus

    Institute of Scientific and Technical Information of China (English)

    Wang Xingwei; Sun Yonggang; Xu Mei; Fang Dianchun; Gao Hengjun; Xu Jiangtao

    2008-01-01

    Objective: To analyze the differential expression genes (DEGs) between Barrett's esophagus (BE) and normal esophagus mucosa and explore the target genes related to the development and progression of BE. Methods: The total RNAs of matched BE and normal esophagus mucosa of BE patients were isolated using one step Trizol method.Matched RNAs were qualified using 10 g/L agarose gel electrophoresis, cRNAs were synthesized, fluorescence labeled and purified after total RNAs were purified. The RNAs of BE and normal esophagus mucosa were hybridized with Agilent oligomicroarray (30 968 probes). The fluorescence intensity features were detected by Agilent scanner and quantified by feature extraction software. Results: (1) The total RNA, reverse transcription product and fluorescence labeled cRNA were all of high quality; (2) There were 142 up-regulated genes and 284 down-regulated genes among 2-fold DEGs. Conclusion: Microarray-based studies are feasible in endoscopically obtained tissues. Many BE-associated genes are screened by the high-throughput gene chip. The development and progression of BE is a complicated process involving multiple genes and multiple procedures, and functional study of these genes may help to identify the key genes or pathways involved in the pathogenesis and development of BE.

  9. The Influence of Agility Training on Physiological and Cognitive Performance

    Science.gov (United States)

    2010-11-01

    the traditional group. The latter could have been due to more general activity or to greater excess post-exercise oxygen consumption ( EPOC ). The...magnitude of EPOC after exercise generally depends on both the duration and intensity of exercise. However, differences in exercise mode may...contribute to the discrepant findings of EPOC magnitude and duration (Borsheim and Bahr, 2003.) Future studies comparing agility training to linear running

  10. Examining the Impact of Strategic Learning on Strategic Agility

    OpenAIRE

    Wael Mohamad Subhi Idris; Methaq Taher Kadhim AL-Rubaie

    2013-01-01

    The main aim of this study is to examining the Impact of Strategic Learning on Strategic Agility in Elba House Company in Jordan. The study adopts the demonstrative analytical approach to achieve their objectives. A total of (55) individual, (47) were respondents and answered the questionnaire distributed. The study finding that the strategic learning (strategic knowledge creation, strategic knowledge distribution, strategic knowledge interpretation and of strategic knowledge implementation) ...

  11. An agile and cooperative architecture for distributed manufacturing systems

    OpenAIRE

    Leitão, Paulo; Restivo, Francisco

    2001-01-01

    World-wide competition among enterprises leads to the need for new systems to perform the control of distributed manufacturing systems, through the integration of information systems and self-organisation features, in order to adapt quickly to the environment changes. This paper presents an agile and cooperative architecture for distributed manufacturing systems based in the multiagent technology which implements some holonic and bionic concepts and supports a new control approach, including ...

  12. Agile development of a virtual reality cognitive assessment

    OpenAIRE

    Koenig, Sebastian T.; Krch, Denise; Chiaravalloti, Nancy; Lengenfelder, Jean; Nikelshpur, Olga; Lange, Belinda; DeLuca, John; Albert A. Rizzo

    2014-01-01

    In recent years user-centered design, participatory design and agile development have seen much popularity in the field of software development. More specifically, applying these methods to user groups with cognitive and motor disabilities has been the topic of numerous publications. However, neuropsychological assessment and training require special consideration to include therapists and brain-injured patients into the development cycle. Application goals, development tools and comm...

  13. BPM, Agile, and Virtualization Combine to Create Effective Solutions

    Directory of Open Access Journals (Sweden)

    Robert Hyer

    2012-07-01

    Full Text Available The rate of change in business and government is accelerating. A number of techniques for addressing that change have emerged independently to provide for automated solutions in this environment. This paper will examine three of the most popular of these technologies— business process management, the agile software development movement, and infrastructure virtualization— to expose the commonalities in these approaches and how, when used together, their combined effect results in rapidly deployed, more successful solutions.

  14. Considerations for Using Agile in DoD Acquisition

    Science.gov (United States)

    2010-04-01

    successfully used in manufacturing throughout the world for decades, such as ―just-in- time,‖ Lean, Kanban , and work-flow-based planning. Another new...of this analysis is provided in Table 2. 29 Kanban / lean style of Agile might be the most relevant for this phase. 31 | CMU/SEI-2010-TN-002...family of approaches, including Kanban [14], Rational Unified Process (RUP), Personal Software Process (PSP), Team Software Process (TSP), and Cleanroom

  15. In Pursuit of Agile Acquisition: Are We There Yet?

    Science.gov (United States)

    2013-03-01

    bureaucracy in the methodology, and avoid promoting activities that would further expand regulatory guidance and oversight to improve agility. Once an...through an integrated digital system called Blue Force Tracker . Instead of the lack of situational awareness, units now use streaming video to help...to trace forensics collected at other crime scenes or events and trace the data back to specific individuals thus identifying dangerous insurgents

  16. AGILE Observations of the Gravitational-wave Event GW150914

    Science.gov (United States)

    Tavani, M.; Pittori, C.; Verrecchia, F.; Bulgarelli, A.; Giuliani, A.; Donnarumma, I.; Argan, A.; Trois, A.; Lucarelli, F.; Marisaldi, M.; Del Monte, E.; Evangelista, Y.; Fioretti, V.; Zoli, A.; Piano, G.; Munar-Adrover, P.; Antonelli, L. A.; Barbiellini, G.; Caraveo, P.; Cattaneo, P. W.; Costa, E.; Feroci, M.; Ferrari, A.; Longo, F.; Mereghetti, S.; Minervini, G.; Morselli, A.; Pacciani, L.; Pellizzoni, A.; Picozza, P.; Pilia, M.; Rappoldi, A.; Sabatini, S.; Vercellone, S.; Vittorini, V.; Giommi, P.; Colafrancesco, S.; Cardillo, M.; Galli, M.; Fuschino, F.

    2016-07-01

    We report the results of an extensive search through the AGILE data for a gamma-ray counterpart to the LIGO gravitational-wave (GW) event GW150914. Currently in spinning mode, AGILE has the potential of cover 80% of the sky with its gamma-ray instrument, more than 100 times a day. It turns out that AGILE came within a minute of the event time of observing the accessible GW150914 localization region. Interestingly, the gamma-ray detector exposed ∼65% of this region during the 100 s time intervals centered at ‑100 and +300 s from the event time. We determine a 2σ flux upper limit in the band 50 MeV–10 GeV, UL = 1.9 × 10‑8 erg cm‑2 s‑1, obtained ∼300 s after the event. The timing of this measurement is the fastest ever obtained for GW150914, and significantly constrains the electromagnetic emission of a possible high-energy counterpart. We also carried out a search for a gamma-ray precursor and delayed emission over five timescales ranging from minutes to days: in particular, we obtained an optimal exposure during the interval ‑150/‑30 s. In all these observations, we do not detect a significant signal associated with GW150914. We do not reveal the weak transient source reported by Fermi-GBM 0.4 s after the event time. However, even though a gamma-ray counterpart of the GW150914 event was not detected, the prospects for future AGILE observations of GW sources are decidedly promising.

  17. Observing peculiar γ-ray pulsars with AGILE

    Science.gov (United States)

    Pilia, M.; Pellizzoni, A.

    2011-08-01

    The AGILE γ-ray satellite provides large sky exposure levels (>=109 cm2 s per year on the Galactic Plane) with sensitivity peaking at E ~100 MeV where the bulk of pulsar energy output is typically released. Its ~1 μs absolute time tagging capability makes it perfectly suited for the study of γ-ray pulsars. AGILE collected a large number of γ-ray photons from EGRET pulsars (>=40,000 pulsed counts for Vela) in two years of observations unveiling new interesting features at sub-millisecond level in the pulsars' high-energy light-curves, γ-ray emission from pulsar glitches and Pulsar Wind Nebulae. AGILE detected about 20 nearby and energetic pulsars with good confidence through timing and/or spatial analysis. Among the newcomers we find pulsars with very high rotational energy losses, such as the remarkable PSR B1509-58 with a magnetic field in excess of 1013 Gauss, and PSR J2229+6114 providing a reliable identification for the previously unidentified EGRET source 3EG2227+6122. Moreover, the powerful millisecond pulsar B1821-24, in the globular cluster M28, is detected during a fraction of the observations.

  18. AGILE Observations of the Gravitational Wave Event GW150914

    CERN Document Server

    Tavani, M; Verrecchia, F; Bulgarelli, A; Giuliani, A; Donnarumma, I; Argan, A; Trois, A; Lucarelli, F; Marisaldi, M; Del Monte, E; Evangelista, Y; Fioretti, V; Zoli, A; Piano, G; Munar-Adrover, P; Antonelli, L A; Barbiellini, G; Caraveo, P; Cattaneo, P W; Costa, E; Feroci, M; Ferrari, A; Longo, F; Mereghetti, S; Minervini, G; Morselli, A; Pacciani, L; Pellizzoni, A; Picozza, P; Pilia, M; Rappoldi, A; Sabatini, S; Vercellone, S; Vittorini, V; Giommi, P; Colafrancesco, S; Cardillo, M

    2016-01-01

    We report the results of an extensive search in the AGILE data for a gamma-ray counterpart of the LIGO gravitational wave event GW150914. Currently in spinning mode, AGILE has the potential of covering with its gamma-ray instrument 80 % of the sky more than 100 times a day. It turns out that AGILE came within a minute from the event time of observing the accessible GW150914 localization region. Interestingly, the gamma-ray detector exposed about 65 % of this region during the 100 s time intervals centered at -100 s and +300 s from the event time. We determine a 2-sigma flux upper limit in the band 50 MeV - 10 GeV, $UL = 1.9 \\times 10^{-8} \\rm \\, erg \\, cm^{-2} \\, s^{-1}$ obtained about 300 s after the event. The timing of this measurement is the fastest ever obtained for GW150914, and significantly constrains the electromagnetic emission of a possible high-energy counterpart. We also carried out a search for a gamma-ray precursor and delayed emission over timescales ranging from minutes to days: in particular...

  19. Agile Data Curation at a State Geological Survey

    Science.gov (United States)

    Hills, D. J.

    2015-12-01

    State agencies, including geological surveys, are often the gatekeepers for myriad data products essential for scientific research and economic development. For example, the Geological Survey of Alabama (GSA) is mandated to explore for, characterize, and report Alabama's mineral, energy, water, and biological resources in support of economic development, conservation, management, and public policy for the betterment of Alabama's citizens, communities, and businesses. As part of that mandate, the GSA has increasingly been called upon to make our data more accessible to stakeholders. Even as demand for greater data accessibility grows, budgets for such efforts are often small, meaning that agencies must do more for less. Agile software development has yielded efficient, effective products, most often at lower cost and in shorter time. Taking guidance from the agile software development model, the GSA is working towards more agile data management and curation. To date, the GSA's work has been focused primarily on data rescue. By using workflows that maximize clear communication while encouraging simplicity (e.g., maximizing the amount of work not done or that can be automated), the GSA is bringing decades of dark data into the light. Regular checks by the data rescuer with the data provider (or their proxy) provides quality control without adding an overt burden on either party. Moving forward, these workflows will also allow for more efficient and effective data management.

  20. Clustering-based urbanisation to improve enterprise information systems agility

    Science.gov (United States)

    Imache, Rabah; Izza, Said; Ahmed-Nacer, Mohamed

    2015-11-01

    Enterprises are daily facing pressures to demonstrate their ability to adapt quickly to the unpredictable changes of their dynamic in terms of technology, social, legislative, competitiveness and globalisation. Thus, to ensure its place in this hard context, enterprise must always be agile and must ensure its sustainability by a continuous improvement of its information system (IS). Therefore, the agility of enterprise information systems (EISs) can be considered today as a primary objective of any enterprise. One way of achieving this objective is by the urbanisation of the EIS in the context of continuous improvement to make it a real asset servicing enterprise strategy. This paper investigates the benefits of EISs urbanisation based on clustering techniques as a driver for agility production and/or improvement to help managers and IT management departments to improve continuously the performance of the enterprise and make appropriate decisions in the scope of the enterprise objectives and strategy. This approach is applied to the urbanisation of a tour operator EIS.

  1. Provide a Mechanism for Enhancing Architecture in Agile Methods XP

    Directory of Open Access Journals (Sweden)

    Sajjad Behzady

    2013-11-01

    Full Text Available Agile software development is an approach to software that focuses on lightweight processes and adaptability to change. The best-known agile methodology is called Extreme Programming. It suggests twelve practices that include iterative development practices, automated unit testing, and pair programming. One challenge of XP agile method in software development is this method's underestimation over software quality attribution; these attributes are of main indices of software architecture. In this study, a method is represented for responding this challenge on the bases of probability theory. In this method, firstly, the rating matrix is structured on the bases of quality attributions an architecture solutions. Each element of this matrix shows a rating for every solution and the ratings will be initialized through analytic hierarchy process (AHP. Via quality weight implement on above matrix the rating vector is created whose each element represents the rate of each solution in reaching those quality attributes in rating matrix. Because rating vector follows normal probable distribution, its elements' rating probable density is mostly gathered around the mean. In this study, the probable density of architecture will be defined, the appropriateness of a solution in comparison to other solutions will be evaluatedor and the respond to XP challenge will be done easily in order to reach architecture solutions in the frame of rating vector.A complex of data are gathered and the results are compared in an experimental method in order to investigate the represented method of this paper.

  2. THE EFFECTS OF STATIC AND DYNAMIC STRETCHING ON AGILITY PERFORMANCE

    Directory of Open Access Journals (Sweden)

    Bergun MERİÇ

    2014-04-01

    Full Text Available The aim of this study was to determine the effects of static and dynamic stretching protocols on agility performance in warm-up sessions. Twenty-three football players (mean ± SD age = 15,04± 0,77 years; weight = 62,35± 6,48kg; height = 1,73± 0,06cm participated to this study from Kocaeli Amateur Football League. Three different warm-up protocols were applied to the players every 48 hours. The first protocol was a general warm-up consisting of 5 minutes jogging with no stretching (GWU+NS, the second protocol was GWU with dynamic stretching (GWU+DS and the third protocol was GWU with static stretching (GWU+SS respectively. In the GWU+DS and GWU+SS protocols, 10 different movements were worked out with 12-15 repetitions in 30 seconds for each muscle group. Following each protocols, the players applied an agility performance test. SPSS (17.0 program used to compare the data obtained from 3 protocols and between two of them. In result, there were no statistically differences between NS and SS protocols (p>0.05. However, statistically difference was seen between DS and SS protocols and between DS and NS protocols (p<0.05. The warm up protocols consist of dynamic stretching exercises before agility activities should be preferred to have better performance.

  3. Understanding the Tenets of Agile Software Engineering: Lecturing, Exploration and Critical Thinking

    CERN Document Server

    Soundararajan, Shvetha; Chigani, Amine

    2010-01-01

    The use of agile principles and practices in software development is becoming a powerful force in today's workplace. In our quest to develop better products, therefore, it is imperative that we strive to learn and understand the application of Agile methods, principles and techniques to the software development enterprise. Unfortunately, in many educational institutions courses and projects that emphasize Agile Software Development are minimal. At best, students have only limited exposure to the agile philosophy, principles and practices at the graduate and undergraduate levels of education. In an effort to address this concern, we offered a graduate-level course entitled "Agile Software Engineering" in the Department of Computer Science at Virginia Tech in Fall 2009. The primary objectives of the class were to introduce the values, principles and practices underlying the agile philosophy, and to do so in an atmosphere that encourages debate and critical thinking. The course was designed around three central ...

  4. Final Report of the NASA Office of Safety and Mission Assurance Agile Benchmarking Team

    Science.gov (United States)

    Wetherholt, Martha

    2016-01-01

    To ensure that the NASA Safety and Mission Assurance (SMA) community remains in a position to perform reliable Software Assurance (SA) on NASAs critical software (SW) systems with the software industry rapidly transitioning from waterfall to Agile processes, Terry Wilcutt, Chief, Safety and Mission Assurance, Office of Safety and Mission Assurance (OSMA) established the Agile Benchmarking Team (ABT). The Team's tasks were: 1. Research background literature on current Agile processes, 2. Perform benchmark activities with other organizations that are involved in software Agile processes to determine best practices, 3. Collect information on Agile-developed systems to enable improvements to the current NASA standards and processes to enhance their ability to perform reliable software assurance on NASA Agile-developed systems, 4. Suggest additional guidance and recommendations for updates to those standards and processes, as needed. The ABT's findings and recommendations for software management, engineering and software assurance are addressed herein.

  5. The Adapted V-Model: A Practical Approach to Agile Testing

    Directory of Open Access Journals (Sweden)

    Yasser Ghanim

    2015-07-01

    Full Text Available Agile methods largely remove the distinction between phases and roles with no predefined order of activities. Some agile approaches such as Test-Driven Development (TDD switch the traditional order of coding and testing and largely remove the boundary between the two implying that testing is becoming more a technical responsibility of the developers! Testers are complaining of loss of identity and scope within agile teams. In parallel some modern non-agile testing approaches such as Risk-based testing also open the boundaries between testing and analysis and suggest more involvement of testers in business and system analysis and sometimes system architecture. This article devises an adapted version of the V-Model for Scrum and suggests a practical approach that aligns the modern testing approaches with agile methodolgies. Scrum will be taken as a representative for Agile. The proposed approach is developed based on the Testing Process Improvement Guide (TPIG developed by the Software Engineering Competence Center.

  6. Lifecycle Agile Supply Chain Modeling for Customized and ComplicatedProducts Based on CPC

    Institute of Scientific and Technical Information of China (English)

    景旭文; 赵良才; 张庆奎

    2004-01-01

    Customized and complicated products are usually high-priced with a long lifecycle. They provide customers with some maintenance capacity. While a great deal of research on product lifecycle design has been carried out, studies on the lifecycle agile supply chain (LASC) are less covered. The LASC functions, management goals, mathematical expressions and overall descriptions of the information model are discussed in this paper. The product lifecycle configuration is a core of the LASC information flow. The structure,function, manufacturing and maintenance configuration views are generated by coordinated lifecycle design. Purchase view 1 in the manufacturing phase is formed by combining the manufacturing configuration with B2B supply model, while purchase view 2 in the maintenance phase is formed by combining maintenance configuration with B2C supply model, serving the production and repair planning respectively. A prototype system has included some basic functions of this model.

  7. Experiment list: SRX088969 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available iate into specialized cells. 59749730,89.3,37.2,913 GSM773066: HA ChIP in ES cells expressing... HAZFP57 source_name=HA ChIP in ES cells expressing HAZFP57 || cell type=embryonic stem (ES) cel

  8. Design and Characterization of Frequency Agile RF and Microwave Devices using Ferroelectrics

    Science.gov (United States)

    2006-01-01

    very high Q (> 2000) resonators. Agilent has pioneered its use in low loss, compact filters and duplexers for mobile handsets. MEMS devices also offer...increased mobility . Various frequency-agile devices such as tunable filters, matching networks, phase shifters, and antennas have been reported using...www.paratek.com [35] Agile Materials and Technolgies Inc., Goleta, CA, USA [Online] http://www.agilematerials.com [36] nGimat Corporation, Atlanta

  9. Addressing the Barriers to Agile Development in the Department of Defense: Program Structure, Requirements, and Contracting

    Science.gov (United States)

    2015-04-30

    barriers within the DoD acquisition system (Broadus, 2013). MITRE performed initial research to examine the leading Agile methodologies and commercial...that suit each organization’s IT environment. Various Agile methods (e.g., Scrum , Extreme Programming (XP), Kanban, Test Driven Development) have... methodology . Traditional waterfall programs usually have discrete acquisition phases driven by milestone events to deliver a large capability. Agile is more

  10. Using the Agile Development Methodology and Applying Best Practice Project Management Processes

    Science.gov (United States)

    2014-12-01

    decisions made by the programming group will ever be architecturally significant (Abrahamsson, Ali Babar , and Kruchten 2010, 18). Agile factions...point at the analysis and documentation that accompanies it, stating it is generally “you ain’t gonna need it” (YAGNI) (Abrahamsson, Ali Babar , and...Abrahamsson, Pekka, Muhammad Ali Babar and Philippe Kruchten. 2010. “Agility and Architecture: Can They Coexist?” IEEE Software 27(2):16-22. Agile

  11. Reusable Component Technology in the Development of Agile Supply Chain Management System

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Agile Supply Chain Management (ASCM) is one of the ke y techniques, which support dynamic enterprise alliance and realize agile manufa cturing. But the optimal run of ASCS depends on a good-constructed Agile Supply Chain Management System (ASCMS), so that the materials flow, information flow a nd funding flow in the supply chain are used with high efficiency. The requireme nts of ASCMS are constantly changeable, which requires that ASCMS has dynamical reuse, integration and open interface. Reusable compo...

  12. The influence of physical and cognitive factors on reactive agility performance in men basketball players.

    Science.gov (United States)

    Scanlan, Aaron; Humphries, Brendan; Tucker, Patrick S; Dalbo, Vincent

    2014-01-01

    This study explored the influence of physical and cognitive measures on reactive agility performance in basketball players. Twelve men basketball players performed multiple sprint, Change of Direction Speed Test, and Reactive Agility Test trials. Pearson's correlation analyses were used to determine relationships between the predictor variables (stature, mass, body composition, 5-m, 10-m and 20-m sprint times, peak speed, closed-skill agility time, response time and decision-making time) and reactive agility time (response variable). Simple and stepwise regression analyses determined the individual influence of each predictor variable and the best predictor model for reactive agility time. Morphological (r = -0.45 to 0.19), sprint (r = -0.40 to 0.41) and change-of-direction speed measures (r = 0.43) had small to moderate correlations with reactive agility time. Response time (r = 0.76, P = 0.004) and decision-making time (r = 0.58, P = 0.049) had large to very large relationships with reactive agility time. Response time was identified as the sole predictor variable for reactive agility time in the stepwise model (R(2) = 0.58, P = 0.004). In conclusion, cognitive measures had the greatest influence on reactive agility performance in men basketball players. These findings suggest reaction and decision-making drills should be incorporated in basketball training programmes.

  13. Application of factor analysis for agile supply chain classification: A case study on the Iranian automotive parts supplier (SAPKO

    Directory of Open Access Journals (Sweden)

    Davood Rafeie rad

    2011-10-01

    Full Text Available Today automotive companies must pioneer in strategies such as the agile supply chain for competition and various demands of customers. Considering the importance of agile in choosing a supplier at the supply chain, this study tries to identify and evaluate agile activities in SAPCO Company suppliers. Then, using principal component analysis of factor analysis, a number of related activities are divided into smaller groups called factor. The results are used by SAPCO to determine agile patterns in selecting a supplier with emphasis on similarities and differences and create agile portfolio. The study can help SAPCO identify criteria and making decision in the field of agile at suppliers.

  14. Reactive Agility Performance in Handball; Development and Evaluation of a Sport-Specific Measurement Protocol.

    Science.gov (United States)

    Spasic, Miodrag; Krolo, Ante; Zenic, Natasa; Delextrat, Anne; Sekulic, Damir

    2015-09-01

    There is no current study that examined sport-specific tests of reactive-agility and change-of-direction-speed (CODS) to replicate real-sport environment in handball (team-handball). This investigation evaluated the reliability and validity of two novel tests designed to assess reactive-agility and CODS of handball players. Participants were female (25.14 ± 3.71 years of age; 1.77 ± 0.09 m and 74.1 ± 6.1 kg) and male handball players (26.9 ± 4.1 years of age; 1.90 ± 0.09 m and 93.90±4.6 kg). Variables included body height, body mass, body mass index, broad jump, 5-m sprint, CODS and reactive-agility tests. Results showed satisfactory reliability for reactive-agility-test and CODS-test (ICC of 0.85-0.93, and CV of 2.4-4.8%). The reactive-agility and CODS shared less than 20% of the common variance. The calculated index of perceptual and reactive capacity (P&RC; ratio between reactive-agility- and CODS-performance) is found to be valid measure in defining true-game reactive-agility performance in handball in both genders. Therefore, the handball athletes' P&RC should be used in the evaluation of real-game reactive-agility performance. Future studies should explore other sport-specific reactive-agility tests and factors associated to such performance in sports involving agile maneuvers. Key pointsReactive agility and change-of-direction-speed should be observed as independent qualities, even when tested over the same course and similar movement templateThe reactive-agility-performance of the handball athletes involved in defensive duties is closer to their non-reactive-agility-score than in their peers who are not involved in defensive dutiesThe handball specific "true-game" reactive-agility-performance should be evaluated as the ratio between reactive-agility and corresponding CODS performance.

  15. Architecture and performances of the AGILE Telemetry Preprocessing System (TMPPS)

    Science.gov (United States)

    Trifoglio, M.; Bulgarelli, A.; Gianotti, F.; Lazzarotto, F.; Di Cocco, G.; Fuschino, F.; Tavani, M.

    2008-07-01

    AGILE is an Italian Space Agency (ASI) satellite dedicated to high energy Astrophysics. It was launched successfully on 23 April 2007, and it has been operated by the AGILE Ground Segment, consisting of the Ground Station located in Malindi (Kenia), the Mission Operations Centre (MOC) and the AGILE Data Centre (ADC) established in Italy, at Telespazio in Fucino and at the ASI Science Data Centre (ASDC) in Frascati respectively. Due to the low equatorial orbit at ~ 530 Km. with inclination angle of ~ 2.5°, the satellite passes over the Ground Station every ~ 100'. During the visibility period of . ~ 12', the Telemetry (TM) is down linked through two separated virtual channels, VC0 and VC1. The former is devoted to the real time TM generated during the pass at the average rate of 50 Kbit/s and is directly relayed to the Control Centre. The latter is used to downlink TM data collected on the satellite on-board mass memory during the non visibility period. This generates at the Ground Station a raw TM file of up to 37 MByte. Within 20' after the end of the contact, both the real time and mass memory TM arrive at ADC through the dedicated VPN ASINet. Here they are automatically detected and ingested by the TMPPS pipeline in less than 5 minutes. The TMPPS archives each TM file and sorts its packets into one stream for each of the different TM layout. Each stream is processed in parallel in order to unpack the various telemetry field and archive them into suitable FITS files. Each operation is tracked into a MySQL data base which interfaces the TMPPS pipeline to the rest of the scientific pipeline running at ADC. In this paper the architecture and the performance of the TMPPS will be described and discussed.

  16. Planning and scheduling for agile manufacturers: The Pantex Process Model

    Energy Technology Data Exchange (ETDEWEB)

    Kjeldgaard, E.A. [Sandia National Labs., Albuquerque, NM (United States). Transportation Systems Analysis Dept.; Jones, D.A. [Parallax, Inc., Albuquerque, NM (United States); List, G.F. [Rensselaer Polytechnic Inst., Troy, NY (United States); Tumquist, M.A. [Cornell Univ., Ithaca, NY (United States)

    1998-02-01

    Effective use of resources that are shared among multiple products or processes is critical for agile manufacturing. This paper describes the development and implementation of a computerized model to support production planning in a complex manufacturing system at the Pantex Plant, a US Department of Energy facility. The model integrates two different production processes (nuclear weapon disposal and stockpile evaluation) that use common facilities and personnel at the plant. The two production processes are characteristic of flow-shop and job shop operations. The model reflects the interactions of scheduling constraints, material flow constraints, and the availability of required technicians and facilities. Operational results show significant productivity increases from use of the model.

  17. Impact of emerging technologies on future combat aircraft agility

    Science.gov (United States)

    Nguyen, Luat T.; Gilert, William P.

    1990-01-01

    The foreseeable character of future within-visual-range air combat entails a degree of agility which calls for the integration of high-alpha aerodynamics, thrust vectoring, intimate pilot/vehicle interfaces, and advanced weapons/avionics suites, in prospective configurations. The primary technology-development programs currently contributing to these goals are presently discussed; they encompass the F-15 Short Takeoff and Landing/Maneuver Technology Demonstrator Program, the Enhanced Fighter Maneuverability Program, the High Angle-of-Attack Technology Program, and the X-29 Technology Demonstrator Program.

  18. Flexible ERP: Enterprise Information System Under the Agile Manufacture Mode

    Institute of Scientific and Technical Information of China (English)

    SU Xuanliang; CHENG Guoping; WANG Mingquan

    2006-01-01

    Flexibility is the demand of management revolution, and also the milestone of management development. The flexible ERP system is the information system to orientate variety and handle uncertainties. The market with rapid change and agile manufacture need a flexible ERP system.The article elaborates the meanings and characteristics about flexibility, the flexibility of ERP and the flexible ERP system; it discussed the necessity, the possibility and the related condition of setting up the flexible ERP system; and puts forward the strategy and the approaches of setting up the flexible ERP system.

  19. CAPE: Context-Aware Agile Business Process Engine

    OpenAIRE

    Rychkova, Irina; Kirsch Pinheiro, Manuele; Le Grand, Bénédicte

    2013-01-01

    National audience; L'avenir de la gestion des processus d'entreprise va voir évoluer des systèmes actuels reposant sur les workflows vers des structures dynamiques agiles sensibles au contexte, qui exploitent l'adaptabilité locale. Afin de permettre cette agilité, nous proposons notre vision de Business Process Management sensible au contexte, reposant sur la modélisation déclarative combinée à une gestion de contexte innovante et à l'Analyse Formelle de Concepts. Au cours de cette présentati...

  20. Development of EarthCube Governance: An Agile Approach

    Science.gov (United States)

    Pearthree, G.; Allison, M. L.; Patten, K.

    2013-12-01

    Governance of geosciences cyberinfrastructure is a complex and essential undertaking, critical in enabling distributed knowledge communities to collaborate and communicate across disciplines, distances, and cultures. Advancing science with respect to 'grand challenges," such as global climate change, weather prediction, and core fundamental science, depends not just on technical cyber systems, but also on social systems for strategic planning, decision-making, project management, learning, teaching, and building a community of practice. Simply put, a robust, agile technical system depends on an equally robust and agile social system. Cyberinfrastructure development is wrapped in social, organizational and governance challenges, which may significantly impede progress. An agile development process is underway for governance of transformative investments in geosciences cyberinfrastructure through the NSF EarthCube initiative. Agile development is iterative and incremental, and promotes adaptive planning and rapid and flexible response. Such iterative deployment across a variety of EarthCube stakeholders encourages transparency, consensus, accountability, and inclusiveness. A project Secretariat acts as the coordinating body, carrying out duties for planning, organizing, communicating, and reporting. A broad coalition of stakeholder groups comprises an Assembly (Mainstream Scientists, Cyberinfrastructure Institutions, Information Technology/Computer Sciences, NSF EarthCube Investigators, Science Communities, EarthCube End-User Workshop Organizers, Professional Societies) to serve as a preliminary venue for identifying, evaluating, and testing potential governance models. To offer opportunity for broader end-user input, a crowd-source approach will engage stakeholders not involved otherwise. An Advisory Committee from the Earth, ocean, atmosphere, social, computer and library sciences is guiding the process from a high-level policy point of view. Developmental

  1. An agile enterprise regulation architecture for health information security management.

    Science.gov (United States)

    Chen, Ying-Pei; Hsieh, Sung-Huai; Cheng, Po-Hsun; Chien, Tsan-Nan; Chen, Heng-Shuen; Luh, Jer-Junn; Lai, Jin-Shin; Lai, Feipei; Chen, Sao-Jie

    2010-09-01

    Information security management for healthcare enterprises is complex as well as mission critical. Information technology requests from clinical users are of such urgency that the information office should do its best to achieve as many user requests as possible at a high service level using swift security policies. This research proposes the Agile Enterprise Regulation Architecture (AERA) of information security management for healthcare enterprises to implement as part of the electronic health record process. Survey outcomes and evidential experiences from a sample of medical center users proved that AERA encourages the information officials and enterprise administrators to overcome the challenges faced within an electronically equipped hospital.

  2. Modeling and control of an agile tail-sitter aircraft

    OpenAIRE

    WANG, XINHUA; Chen, Zengqiang; Yuan, Zhuzhi

    2015-01-01

    This paper presents a model of an agile tail-sitter aircraft, which can operate as a helicopter as well as capable of transition to fixed-wing flight. Aerodynamics of the co-axial counter-rotating propellers with quad rotors are analysed under the condition that the co-axial is operated at equal rotor torque (power). A finite-time convergent observer based on Lyapunov function is presented to estimate the unknown nonlinear terms in co-axial counter-rotating propellers, the uncertainties and e...

  3. Adopting SCRUM Agile Project Management for Managing Academic Institutions

    Directory of Open Access Journals (Sweden)

    Abdullah Basahel

    2015-01-01

    Full Text Available Managing academic institutions can be challenging and different than managing other organizations. This is because the staffs are highly qualified and may even be at the same and sometimes even higher academic level than their managers. An autocratic style of leadership may lead to tensions and be problematic for the organization. Therefore, a more democratic approach is required. SCRUM is an agile project management method, mainly used in IT domain. SCRUM teams have no manager and rely on the team to control its members. This paper will attempt to illustrate, how the SCRUM methodology can be used to manage an academic institution.

  4. EvolvingWeb-Based Test Automation into Agile Business Specifications

    Directory of Open Access Journals (Sweden)

    David Streader

    2011-06-01

    Full Text Available Usually, test automation scripts for a web application directly mirror the actions that the tester carries out in the browser, but they tend to be verbose and repetitive, making them expensive to maintain and ineffective in an agile setting. Our research has focussed on providing tool-support for business-level, example-based specifications that are mapped to the browser level for automatic verification. We provide refactoring support for the evolution of existing browser-level tests into business-level specifications. As resulting business rule tables may be incomplete, redundant or contradictory, our tool provides feedback on coverage.

  5. The Usability Expert’s Fear of Agility

    DEFF Research Database (Denmark)

    Nielsen, Lene; Madsen, Sabine

    2012-01-01

    This paper contributes to the HCI literature on usability practice with insights about the empirical challenges and global emerging practices caused by the advent of agile software development (ASD). In the paper we report from a worldwide study involving 12 usability professionals from 12...... different countries. The findings show that the usability professionals share a forced development and innovation in their practice that stem from their clients’ adoption and use of ASD methods. The ASD methods challenge the way usability testing is performed, the abilities of the usability expert......, the usability deliverables, and the experts’ assumptions about the importance of validity....

  6. Perspectives on Industrial Innovation from Agilent, HP, and Bell Labs

    Science.gov (United States)

    Hollenhorst, James

    2014-03-01

    Innovation is the life blood of technology companies. I will give perspectives gleaned from a career in research and development at Bell Labs, HP Labs, and Agilent Labs, from the point of view of an individual contributor and a manager. Physicists bring a unique set of skills to the corporate environment, including a desire to understand the fundamentals, a solid foundation in physical principles, expertise in applied mathematics, and most importantly, an attitude: namely, that hard problems can be solved by breaking them into manageable pieces. In my experience, hiring managers in industry seldom explicitly search for physicists, but they want people with those skills.

  7. Agile Scheduling for MES in a Complex Information Environment

    Institute of Scientific and Technical Information of China (English)

    LIShu-xia; RAOYun-qing; ZHANGChao-yong

    2005-01-01

    Since Manufacturing Execution System (MES) is a bridge which links the upper planning system of the enterprise and the control system of the shop floor, various kinds of the information with different characteristics flow through the system. The information environment of MES and its effect on MES scheduling are analyzed. A methodological proposal is given to address the problem of agile scheduling in a complex information environment, based on which a microeconomic market and game theoretic model-based scheduling approach is presented. The future development of this method is also discussed.

  8. Conceptual Framework and Curriculum for Networked Agile Manufacturing

    Institute of Scientific and Technical Information of China (English)

    周杰韩; 熊光楞; 张和明; 曾庆良

    2003-01-01

    Networked agile manufacturing (NAM) is a new manufacturing paradigm for the 21st century.Manufacturing businesses based on NAM are characterized by virtual organization, innovation, global sourcingof materials and production centered on the workforce. Therefore, NAM requires a knowledgeable, motivatedworkforce. This paper reviews the literature related to developing an NAM curriculum to: (1) review theprogress for organizing manufacturing information, (2) study the fundamental technologies impacting NAM,including product data management (PDM), enterprise resource planning (ERP), and component/suppliermanagement (CSM), (3) present a definition of NAM and its conceptual framework, and (4) generalize thebasic NAM curriculum. The NAM curriculum can be used for developing a manufacturing course.

  9. AGILE: a methodology for Advanced Governance of Information services through Legal Engineering

    NARCIS (Netherlands)

    A. Boer; G. Sileno

    2013-01-01

    To address agility in public administration, the Agile project developed a reference knowledge acquisition infrastructure for legal knowledge, based on a dynamic and design-oriented conceptualization of the legal system. The main objective of the project was to reframe legal knowledge as a knowledge

  10. The Impacts of Agile Development Methodology Use on Project Success: A Contingency View

    Science.gov (United States)

    Tripp, John F.

    2012-01-01

    Agile Information Systems Development Methods have emerged in the past decade as an alternative manner of managing the work and delivery of information systems development teams, with a large number of organizations reporting the adoption & use of agile methods. The practitioners of these methods make broad claims as to the benefits of their…

  11. Organizational Culture and the Deployment of Agile Methods: The Competing Values Model View

    Science.gov (United States)

    Iivari, Juhani; Iivari, Netta

    A number of researchers have identified organizational culture as a factor that potentially affects the deployment of agile systems development methods. Inspired by the study of Iivari and Huisman (2007), which focused on the deployment of traditional systems development methods, the present paper proposes a number of hypotheses about the influence of organizational culture on the deployment of agile methods.

  12. Breaking the addiction to process an introduction to agile project management

    CERN Document Server

    Scanlon-Thomas, Elizabeth

    2011-01-01

    Companies using traditional development methods are finding it increasingly difficult to maintain profitable business relationships in today's climate. Agile is a flexible, adaptable system and this book will help you implement it for maximum impact and success for your business. With Agile you can deliver the results your clients want, with the results you want too!

  13. The NERV Methodology: Non-Functional Requirements Elicitation, Reasoning and Validation in Agile Processes

    Science.gov (United States)

    Domah, Darshan

    2013-01-01

    Agile software development has become very popular around the world in recent years, with methods such as Scrum and Extreme Programming (XP). Literature suggests that functionality is the primary focus in Agile processes while non-functional requirements (NFR) are either ignored or ill-defined. However, for software to be of good quality both…

  14. Designing a Model of Organizational Agility: A Case Study of Ardabil Gas Company

    Directory of Open Access Journals (Sweden)

    Behrooz Razmi

    2015-06-01

    Full Text Available Organizational agility means the ability of every organization in sensation, perception, and prediction of available changes in the business environment. The importance of organizational agility in a competitive environment is nowadays widely recognized and accepted. The aim of this research was to design a unified theoretical model of organizational agility for Ardabil Gas Company based upon the theoretical principles of organizational agility proposed by Goldman (1995. Independent variables including organizational intelligence, organizational commitment, and organizational trust were considered as mediator variable and other four essential components of organizational agility such as forming of virtual participation valorize to humanistic knowledge and skills, change readiness, and customers answering were known as dependent variables of research. This is an applied, descriptive-correlation research, conducted by survey methodology. In this study, 568 employees, contractors, and subscribers of Ardabil Gas Company were chosen as the statistical population of the study. For the purpose of the study a questionnaire for data collection was used. Using Structural Equation Modeling (SEM, it is straightforward to test hypotheses of the equality of various correlation coefficients with any number of covariates across multiple groups. The gathered data was analyzed by using SPSS and LISREL software packages. The results of statistical analysis indicate that organizational trust has a significant positive relationship with organizational agility and organizational trust is the moderator of the relationship between technology intelligence and organizational agility and the relationship between organizational commitment and organizational agility.

  15. Impact of Business Intelligence and IT Infrastructure Flexibility on Competitive Advantage: An Organizational Agility Perspective

    Science.gov (United States)

    Chen, Xiaofeng

    2012-01-01

    There is growing use of business intelligence (BI) for better management decisions in industry. However, empirical studies on BI are still scarce in academic research. This research investigates BI from an organizational agility perspective. Organizational agility is the ability to sense and respond to market opportunities and threats with speed,…

  16. Method æ, the agile software development method tailored for the pharmaceutical industry.

    NARCIS (Netherlands)

    Hajou, A.; Batenburg, R.S.; Jansen, S.

    2015-01-01

    Agile software development methods have a high adoption rate due to their proven business benefits. Its success has not yet been identified in the pharmaceutical industry, due to the industry’s incompatibility with generic agile methods. Comprehensive research has been done to engineer a tailored ag

  17. A systematic literature review on agile requirements engineering practices and challenges

    NARCIS (Netherlands)

    Inayat, Irum; Salim, Siti Salwah; Marczak, Sabrina; Daneva, Maya; Shamshirband, Shahaboddin

    2014-01-01

    Unlike traditional software development methods, agile methods are marked by extensive collaboration, i.e. face-to-face communication. Although claimed to be beneficial, the software development community as a whole is still unfamiliar with the role of the requirements engineering practices in agile

  18. Agile methods in biomedical software development: a multi-site experience report

    Directory of Open Access Journals (Sweden)

    Kuhlmman Karl F

    2006-05-01

    Full Text Available Abstract Background Agile is an iterative approach to software development that relies on strong collaboration and automation to keep pace with dynamic environments. We have successfully used agile development approaches to create and maintain biomedical software, including software for bioinformatics. This paper reports on a qualitative study of our experiences using these methods. Results We have found that agile methods are well suited to the exploratory and iterative nature of scientific inquiry. They provide a robust framework for reproducing scientific results and for developing clinical support systems. The agile development approach also provides a model for collaboration between software engineers and researchers. We present our experience using agile methodologies in projects at six different biomedical software development organizations. The organizations include academic, commercial and government development teams, and included both bioinformatics and clinical support applications. We found that agile practices were a match for the needs of our biomedical projects and contributed to the success of our organizations. Conclusion We found that the agile development approach was a good fit for our organizations, and that these practices should be applicable and valuable to other biomedical software development efforts. Although we found differences in how agile methods were used, we were also able to identify a set of core practices that were common to all of the groups, and that could be a focus for others seeking to adopt these methods.

  19. RFID-Based Critical Path Expert System for Agility Manufacture Process Management

    Science.gov (United States)

    Cheng, Haifang; Xiang, Yuli

    This paper presents a critical path expert system for the agility manufacture process management based on radio frequency identification (RFID) technology. The paper explores that the agility manufacture processes can be visible and controllable with RFID. The critical paths or activities can be easily found out and tracked by the RFID tracing technology. And the expert system can optimize the bottle neck of the task process of the agility management with the critical path adjusting and reforming method. Finally, the paper gives a simple application example of the system to discuss how to adjust the critical paths and how to make the process more agility and flexibility with the critical path expert system. With an RFID-based critical path expert system, the agility manufacture process management will be more effective and efficient.

  20. Applying Multi-Criteria Decision-Making Techniques to Prioritize Agility Drivers

    Directory of Open Access Journals (Sweden)

    Ahmad Jafarnejad

    2013-07-01

    Full Text Available It seems that to recognize and classify the factors affecting organizational agility and need to specify the amount of their importance for the organization is essential to preserve survival and success in today's environment. This paper reviews the concept of agility and its division in the following indicators included the factors of motivations organizational agility that have been ranked in terms of level of importance and their influence by the techniques of MCDM. The inner complexity, suppliers, competition, customer needs, market, technology and social factors are the most important factors affecting organizational agility that can evaluate the following indicators and apply them and re-engineering processes, reviews and predictions of customer needs and better understanding of competitive environment and supply chain specify organizational agility and success ultimately.

  1. Improving offshoring of low-budget agile software development using the dual-shore approach

    DEFF Research Database (Denmark)

    Nielsen, Jesper Riber; Hovmøller, Harald; Jørgensen, Michael Thorkild Nørgaard;

    2013-01-01

    of a particular agile offshoring process. Furthermore, the discussion leads to a modification of the original dual-shore approach to fit the characteristics of low-budget development projects. The article explains agile development and elaborates the four basic principles associated with it. The four principles......This paper examines how agile software development can be implemented in an offshore setting by introducing and testing the dual-shore approach. The topic is further enlightened by an analysis and discussion of an autoethnographic study proposing three specific suggestions for improvements...... are then used as a framework throughout the article. A short introduction to the terms outsourcing and offshoring is given, and it is illuminated how agile processes can be implemented into offshored development. The most common difficulties regarding agile offshoring are described and the dual-shore model...

  2. SCXTREME Framework: A Customized Approach of Process Improvements in Agile Blend with CMMI Practices in Pakistan

    Directory of Open Access Journals (Sweden)

    Samina Jan

    2013-02-01

    Full Text Available The proposed framework shows the customized approach that improves the software development process by using the Agile techniques. The proposed research work blends the CMMI practices according to Agile methods of development (specially Scrum, because Scrum is extremely used by Pakistani firms CMMI is a model for the process improvement within organization, but it is too expensive to implement all practices of CMMI for each level. So for small size organizations, at level 2, 3 there are some practices which are helpful in managing and defining their software development process. By implementing the proposed framework, organizations can improve their maturity and capability level.There are several problems while working on Agile, many management areas can be neglected. In SCXTREME there are eight process area selected from CMMI and fit them according to Agile, so agile can be suitable for Pakistani organization by implementing some process area at level 2 and level 3.

  3. Implementasi Cloud Computing Menggunakan Metode Pengembangan Sistem Agile

    Directory of Open Access Journals (Sweden)

    Much Aziz Muslim

    2015-05-01

    Full Text Available Cloud computing merupakan sebuah teknologi yang menyediakan layanan terhadap sumber daya komputasi melalui sebuah jaringan. Sumber daya yang di sediakan di dalam cloud computing meliputi mesin, media penyimpanan data, sistem operasi dan program aplikasi. Fitur dari cloud computing dipercaya akan jauh lebih hemat dan memuaskan. Masalah yang muncul adalah bagaimana mengimplementasi Cloud Computing dengan menggunakan Windows Azure Pack dan bagaimana provisioning Windows Azure Pack SQL Database. Fokus pada penelitian ini adalah pada proses deploying dan provisioning SQL Database Server. Pengimplementasian cloud computing menggunakan metode pengembangan sistem agile dengan langkah-langkah meliputi perencanaan, implementasi, pengujian (test, dokumentasi, deployment dan pemeliharaan. Untuk menjalankan proses tersebut kebutuhan perangkat yang dipersiapkan meliputi perangkat keras seperti PC Server Cisco UCS C240 M3S2, Hardisk 8753 GB, 256 GB RAM, bandwith minimal 1 Mbps dan kebutuhan perangkat lunak meliputi Windows Server 2012 R2, VMM, Windows Azure Pack, IIS, SQL Server 2012 dan Web Patform Installer. Hasil dari implementasi cloud computing menggunakan metode pengembangan sistem agile adalah terbentuknya sebuah sistem cloud hosting provider dengan menggunakan Windows Azure Pack dan SQL Server 2012 sebagai sistem utama dan pengelolaan database menggunakan Microsoft SQL Server Management 

  4. Frequency-agile microwave components using ferroelectric materials

    Science.gov (United States)

    Colom-Ustariz, Jose G.; Rodriguez-Solis, Rafael; Velez, Salmir; Rodriguez-Acosta, Snaider

    2003-04-01

    The non-linear electric field dependence of ferroelectric thin films can be used to design frequency and phase agile components. Tunable components have traditionally been developed using mechanically tuned resonant structures, ferrite components, or semiconductor-based voltage controlled electronics, but they are limited by their frequency performance, high cost, hgih losses, and integration into larger systems. In contrast, the ferroelectric-based tunable microwave component can easily be integrated into conventional microstrip circuits and attributes such as small size, light weight, and low-loss make these components attractive for broadband and multi-frequency applications. Components that are essential elements in the design of a microwave sensor can be fabricated with ferroelectric materials to achieve tunability over a broad frequency range. It has been reported that with a thin ferroelectric film placed between the top conductor layer and the dielectric material of a microstrip structure, and the proper DC bias scheme, tunable components above the Ku band can be fabricated. Components such as phase shifters, coupled line filters, and Lange couplers have been reported in the literature using this technique. In this wokr, simulated results from a full wave electromagnetic simulator are obtained to show the tunability of a matching netowrk typically used in the design of microwave amplifiers and antennas. In addition, simulated results of a multilayer Lange coupler, and a patch antenna are also presented. The results show that typical microstrip structures can be easily modified to provide frequency agile capabilities.

  5. A PROPOSED HYBRID AGILE FRAMEWORK MODEL FOR MOBILE APPLICATIONS DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Ammar Khader Almasri

    2016-03-01

    Full Text Available With the increasing in mobile application systems and a high competition between companies, that led to increase in the number of mobile application projects. Mobile software development is a group of process for creating software for mobile devices with limited resources like small screen, low-power. The development of mobile applications is a big challenging because of rapidly changing business requirements and technical constraints for mobile systems. So, developers faced the challenge of a dynamic environment and the Changing of mobile application requirements. Moreover, Mobile applications should adapt appropriate software development methods that act in response efficiently to these challenges. However, at the moment, there is limited knowledge about the suitability of different software practices for the development of mobile applications. According to many researchers ,Agile methodologies was found to be most suitable for mobile development projects as they are short time, require flexibility, reduces waste and time to market. Finally, in this research we are looking for a suitable process model that conforms to the requirement of mobile application, we are going to investigate agile development methods to find a way, making the development of mobile application easy and compatible with mobile device features.

  6. PDS4 - Some Principles for Agile Data Curation

    Science.gov (United States)

    Hughes, J. S.; Crichton, D. J.; Hardman, S. H.; Joyner, R.; Algermissen, S.; Padams, J.

    2015-12-01

    PDS4, a research data management and curation system for NASA's Planetary Science Archive, was developed using principles that promote the characteristics of agile development. The result is an efficient system that produces better research data products while using less resources (time, effort, and money) and maximizes their usefulness for current and future scientists. The key principle is architectural. The PDS4 information architecture is developed and maintained independent of the infrastructure's process, application and technology architectures. The information architecture is based on an ontology-based information model developed to leverage best practices from standard reference models for digital archives, digital object registries, and metadata registries and capture domain knowledge from a panel of planetary science domain experts. The information model provides a sharable, stable, and formal set of information requirements for the system and is the primary source for information to configure most system components, including the product registry, search engine, validation and display tools, and production pipelines. Multi-level governance is also allowed for the effective management of the informational elements at the common, discipline, and project level. This presentation will describe the development principles, components, and uses of the information model and how an information model-driven architecture exhibits characteristics of agile curation including early delivery, evolutionary development, adaptive planning, continuous improvement, and rapid and flexible response to change.

  7. Caffeine supplementation and reactive agility in elite youth soccer players.

    Science.gov (United States)

    Jordan, J Bradley; Korgaokar, Ajit; Farley, Richard S; Coons, John M; Caputo, Jennifer L

    2014-05-01

    This study examined the effects of caffeine supplementation (6 mg·kg-1) on performance of a reactive agility test (RAT) in 17 elite, male, youth (M = 14 y) soccer players. Using a double-blind, repeated-measures design, players completed 4 days of testing on the RAT after a standardized warm-up. On day 1, anthropometric measurements were taken and players were accommodated to the RAT. On day 2, baseline performance was established. Caffeine or placebo conditions were randomly assigned on day 3 and the condition was reversed on day 4. Players completed 3 randomized trials of the RAT on days 2, 3, and 4 with at least 1 trial to the players' dominant and nondominant sides. There were no significant differences among conditions in reaction time (RT) to the dominant side, heart rates at any point of measurement, or ratings of perceived exertion (RPE) after completion of the warm-up. Caffeine produced faster RT to the nondominant side (P = .041) and higher RPE at the conclusion of the RAT (P = .013). The effect on the total time (TT) to complete the agility test to the nondominant side approached significance (P = .051). Sprint time and TT to either side did not differ. Caffeine supplementation may provide ergogenic benefit to elite, male, youth soccer players.

  8. Speed and agility of 12- and 14-year-old elite male basketball players.

    Science.gov (United States)

    Jakovljevic, Sasa T; Karalejic, Milivoje S; Pajic, Zoran B; Macura, Marija M; Erculj, Frane F

    2012-09-01

    The aims of this study were (a) to identify and compare the speed and agility of 12- and 14-year-old elite male basketball players and (b) to investigate relations between speed and agility for both age groups of basketball players, to help coaches to improve their work. Sixty-four players aged 12 (M = 11.98 years, SD = 0.311) and 54 players aged 14 (M = 14.092 years, SD = 0.275) were tested. Three agility tests: agility t-test, zigzag agility drill, and agility run 4 × 15 m and 3 speed tests: 20-m run, 30-m run, and 50-m run were applied. Fourteen-year-old players achieved significantly better results in all speed and agility tests compared with 12-year-old players. The correlation coefficient (r = 0.81, p = 0.001) showed that 12-year-old players have the same ability in the 30- and 50-m runs. The other correlation coefficient (r = 0.59, p = 0.001) indicated that 20- and 30-m runs had inherently different qualities. The correlation coefficients between agility tests were year-old players, the correlation coefficients between the speed test results were 0.71, which means that all the 3 tests represent the same quality. During the speed training of 12-year-old players, it is advisable to focus on shorter running distances, up to 30 m. During the agility training of the same players, it is useful to apply exercises with various complexities. In speed training of the 14-year-old players, the 30- and 50-m runs should be applied, and agility training should include more specific basketball movements and activities.

  9. Differential expression of genes and proteins associated with wool follicle cycling.

    Science.gov (United States)

    Liu, Nan; Li, Hegang; Liu, Kaidong; Yu, Juanjuan; Cheng, Ming; De, Wei; Liu, Jifeng; Shi, Shuyan; He, Yanghua; Zhao, Jinshan

    2014-08-01

    Sheep are valuable resources for the wool industry. Wool growth of Aohan fine wool sheep has cycled during different seasons in 1 year. Therefore, identifying genes that control wool growth cycling might lead to ways for improving the quality and yield of fine wool. In this study, we employed Agilent sheep gene expression microarray and proteomic technology to compare the gene expression patterns of the body side skins at August and December time points in Aohan fine wool sheep (a Chinese indigenous breed). Microarray study revealed that 2,223 transcripts were differentially expressed, including 1,162 up-regulated and 1,061 down-regulated transcripts, comparing body side skin at the August time point to the December one (A/D) in Aohan fine wool sheep. Then seven differentially expressed genes were selected to validated the reliability of the gene chip data. The majority of the genes possibly related to follicle development and wool growth could be assigned into the categories including regulation of receptor binding, extracellular region, protein binding and extracellular space. Proteomic study revealed that 84 protein spots showed significant differences in expression levels. Of the 84, 63 protein spots were upregulated and 21 were downregulated in A/D. Finally, 55 protein points were determined through MALDI-TOF/MS analyses. Furthermore, the regulation mechanism of hair follicle might resemble that of fetation.

  10. Experiment list: SRX316310 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available cell type=mouse embryonic stem cells || genotype/variation=expressing Prdm4-EGFP || chip antibody=GFP (clone 3E6) Mouse IgG2a, Monoc...lonal Antibody || chip antibody vendor=Invitrogen http:/

  11. Frequency/phase agile microwave circuits on ferroelectric films

    Science.gov (United States)

    Romanofsky, Robert Raymond

    This work describes novel microwave circuits that can be tuned in either frequency or phase through the use of nonlinear dielectrics, specifically thin ferroelectric films. These frequency and phase agile circuits in many cases provide a new capability or offer the potential for lower cost alternatives in satellite and terrestrial communications and sensor applications. A brief introduction to nonlinear dielectrics and a summary of some of the special challenges confronting the practical insertion of ferroelectric technology into commercial systems is provided. A theoretical solution for the propagation characteristics of the multi-layer structures, with emphasis on a new type of phase shifter based on coupled microstrip, lines, is developed. The quasi-TEM analysis is based on a variational solution for line capacitance and an extension of coupled transmission line theory. It is shown that the theoretical model is applicable to a broad class of multi-layer transmission lines. The critical role that ferroelectric film thickness plays in loss and phase-shift is closely examined. Experimental data for both thin film BaxSr1-xTiO 3 phase shifters near room temperature and SMO3 phase shifters at cryogenic temperatures on MgO and LaAlO3 substrates is included. Some of these devices demonstrated an insertion loss of less than 5 dB at Ku-band with continuously variable phase shift in excess of 360 degrees. The performance of these devices is superior to the state-of-the-art semiconductor counterparts. Frequency and phase agile antenna prototypes including a microstrip patch that can operate at multiple microwave frequency bands and a new type of phased array antenna concept called the ferroelectric reflectarray are introduced. Modeled data for tunable microstrip patch antennas is presented for various ferroelectric film thickness. A prototype linear phased array, with a conventional beam-forming manifold, and an electronic controller is described. This is the first

  12. Dynamic tumor tracking using the Elekta Agility MLC

    Energy Technology Data Exchange (ETDEWEB)

    Fast, Martin F., E-mail: martin.fast@icr.ac.uk; Nill, Simeon, E-mail: simeon.nill@icr.ac.uk; Bedford, James L.; Oelfke, Uwe [Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London SM2 5NG (United Kingdom)

    2014-11-01

    Purpose: To evaluate the performance of the Elekta Agility multileaf collimator (MLC) for dynamic real-time tumor tracking. Methods: The authors have developed a new control software which interfaces to the Agility MLC to dynamically program the movement of individual leaves, the dynamic leaf guides (DLGs), and the Y collimators (“jaws”) based on the actual target trajectory. A motion platform was used to perform dynamic tracking experiments with sinusoidal trajectories. The actual target positions reported by the motion platform at 20, 30, or 40 Hz were used as shift vectors for the MLC in beams-eye-view. The system latency of the MLC (i.e., the average latency comprising target device reporting latencies and MLC adjustment latency) and the geometric tracking accuracy were extracted from a sequence of MV portal images acquired during irradiation for the following treatment scenarios: leaf-only motion, jaw + leaf motion, and DLG + leaf motion. Results: The portal imager measurements indicated a clear dependence of the system latency on the target position reporting frequency. Deducting the effect of the target frequency, the leaf adjustment latency was measured to be 38 ± 3 ms for a maximum target speed v of 13 mm/s. The jaw + leaf adjustment latency was 53 ± 3 at a similar speed. The system latency at a target position frequency of 30 Hz was in the range of 56–61 ms for the leaves (v ≤ 31 mm/s), 71–78 ms for the jaw + leaf motion (v ≤ 25 mm/s), and 58–72 ms for the DLG + leaf motion (v ≤ 59 mm/s). The tracking accuracy showed a similar dependency on the target position frequency and the maximum target speed. For the leaves, the root-mean-squared error (RMSE) was between 0.6–1.5 mm depending on the maximum target speed. For the jaw + leaf (DLG + leaf) motion, the RMSE was between 0.7–1.5 mm (1.9–3.4 mm). Conclusions: The authors have measured the latency and geometric accuracy of the Agility MLC, facilitating its future use for clinical

  13. Lean-Agile Adaptations in Clinical Laboratory Accredited ISO 15189

    Directory of Open Access Journals (Sweden)

    Carlos Vilaplana Pérez

    2015-12-01

    Full Text Available It’s introduced Lean techniques in a Clinical Laboratory to improve the operability and the efficiency in continuous processes of analysis, failsafe systems, analysis of areas of value pursuit of zero defects and reduction of waste, and it promote continuous improvement in presented difficulties in adapting to the changing needs of the healthcare environment. Whereas it is necessary to incorporate certification and accreditation, note that the adaptability of the clinical laboratory to the changing needs of physicians in obtaining analytical information is reduced. The application of an agile methodology on analytical systems can provide a line of work that allows the incorporation of planning short work cycles on equips quickly with operational autonomy on the basis of demand and respecting the accreditation requirements and flexibility to ensure adequate performance as the intercomparison of results from the different units analytics, analytical quality and turnaround times. Between 2012 and 2014, a process of analysis and improvement was applied to circuits, a 5 s system, transportation of samples, inventory of reactive and samples, motion of personal and samples, reductions of waiting and delays, overproduction, over processing, and defects of results and reports. At last it seems necessary to apply the Agile methodology to adapt to the evolving necessities in time and the different origins of the samples. It’s have used modular systems where the modules of this study are programmed with immunoassay techniques and it has reduced the operative modules depending on the required activity, ensuring the goals of turnaround times, analytic quality, service, health care continuity, and keeping up with the ISO 15189 accreditation requirements. The results of applying the concept of Lean-Agile to a modular system allows us to reduce the associated costs to the seasonal variation of the health care demand and to adapt the system to the changes on

  14. Comparison of Gene Expression by Sheep and Human Blood Stimulated with the TLR4 Agonists Lipopolysaccharide and Monophosphoryl Lipid A.

    Directory of Open Access Journals (Sweden)

    Perenlei Enkhbaatar

    Full Text Available Animal models that mimic human biology are important for successful translation of basic science discoveries into the clinical practice. Recent studies in rodents have demonstrated the efficacy of TLR4 agonists as immunomodulators in models of infection. However, rodent models have been criticized for not mimicking important characteristics of the human immune response to microbial products. The goal of this study was to compare genomic responses of human and sheep blood to the TLR4 agonists lipopolysaccharide (LPS and monophosphoryl lipid A (MPLA.Venous blood, withdrawn from six healthy human adult volunteers (~ 28 years old and six healthy adult female sheep (~3 years old, was mixed with 30 μL of PBS, LPS (1μg/mL or MPLA (10μg/mL and incubated at room temperature for 90 minutes on a rolling rocker. After incubation, 2.5 mL of blood was transferred to Paxgene Blood RNA tubes. Gene expression analysis was performed using an Agilent Bioanalyzer with the RNA6000 Nano Lab Chip. Agilent gene expression microarrays were scanned with a G2565 Microarray Scanner. Differentially expressed genes were identified.11,431 human and 4,992 sheep probes were detected above background. Among them 1,029 human and 175 sheep genes were differentially expressed at a stringency of 1.5-fold change (p 1.5-fold changes in human samples. Genes of major inflammatory mediators, such as IL-1, IL-6 and IL-8, TNF alpha, NF-kappaB, ETS2, PTGS2, PTX3, CXCL16, KYNU, and CLEC4E were similarly (>2-fold upregulated by LPS and MPLA in both species.The genomic responses of peripheral blood to LPS and MPLA in sheep are quite similar to those observed in humans, supporting the use of the ovine model for translational studies that mimic human inflammatory diseases and the study of TLR-based immunomodulators.

  15. Pixel detector readout chip

    CERN Multimedia

    1991-01-01

    Close-up of a pixel detector readout chip. The photograph shows an aera of 1 mm x 2 mm containing 12 separate readout channels. The entire chip contains 1000 readout channels (around 80 000 transistors) covering a sensitive area of 8 mm x 5 mm. The chip has been mounted on a silicon detector to detect high energy particles.

  16. The Impact of the Preprocessing Methods in Downstream Analysis of Agilent Microarray Data

    Directory of Open Access Journals (Sweden)

    Loredana BĂLĂCESCU

    2015-12-01

    Full Text Available Over the past decades, gene expression microarrays have been used extensively in biomedical research. However, these high-throughput experiments are affected by technical variation and biases introduced at different levels, such as mRNA processing, labeling, hybridization, scanning and/or imaging. Therefore, data preprocessing is important to minimize these systematic errors in order to identify actual biological changes. The aim of this study was to compare all possible combinations of two normalization, four summarization, and two background correction options, using two different foreground estimates. The results shows that the background correction of the raw median signal and summarization methods used here have no impact in downstream analysis. In contrast, the choice of the normalization method influences the results; the quantile normalization leading to a better biological sensitivity of the data. When Agilent processed signal was considered, regardless of the summarization and normalization options, there were consistently identified more differentially expressed genes (DEG than when raw median signal was used. Nevertheless, the greater number of DEG didn’t result in an improvement of the biological relevance.

  17. Adaptive optimization of agile organization of command and control resource

    Institute of Scientific and Technical Information of China (English)

    Yang Chunhui; Liu Junxian; Chen Honghui; Luo Xueshan

    2009-01-01

    Adaptive optimization is one of the means that agile organization of command and control resource (AOC2R) adapts for the dynamic battlefield environment. A math model of the adaptive optimization of AOC2R is put forward by analyzing the interrelating concept and research. The model takes the adaptive process as a multi-stage decision making problem. The 2-phases method is presented to calculate the model, which obtains the related parameters by running the colored Petri net (CPN) model of AOC2R and then searches for the result by ant colony optimization (ACO) algorithm integrated with genetic optimization techniques. The simulation results demonstrate that the proposed algorithm greatly improves the performance of AOC2R.

  18. Web Services-Enhanced Agile Modeling and Integrating Business Processes

    CERN Document Server

    Belouadha, Fatima-Zahra; Roudiès, Ounsa

    2012-01-01

    In a global business context with continuous changes, the enterprises have to enhance their operational efficiency, to react more quickly, to ensure the flexibility of their business processes, and to build new collaboration pathways with external partners. To achieve this goal, they must use e-business methods, mechanisms and techniques while capitalizing on the potential of new information and communication technologies. In this context, we propose a standards, model and Web services-based approach for modeling and integrating agile enterprise business processes. The purpose is to benefit from Web services characteristics to enhance the processes design and realize their dynamic integration. The choice of focusing on Web services is essentially justified by their broad adoption by enterprises as well as their capability to warranty interoperability between both intra and inter-enterprises systems. Thereby, we propose in this chapter a metamodel for describing business processes, and discuss their dynamic in...

  19. A new algorithm for agile satellite-based acquisition operations

    Science.gov (United States)

    Bunkheila, Federico; Ortore, Emiliano; Circi, Christian

    2016-06-01

    Taking advantage of the high manoeuvrability and the accurate pointing of the so-called agile satellites, an algorithm which allows efficient management of the operations concerning optical acquisitions is described. Fundamentally, this algorithm can be subdivided into two parts: in the first one the algorithm operates a geometric classification of the areas of interest and a partitioning of these areas into stripes which develop along the optimal scan directions; in the second one it computes the succession of the time windows in which the acquisition operations of the areas of interest are feasible, taking into consideration the potential restrictions associated with these operations and with the geometric and stereoscopic constraints. The results and the performances of the proposed algorithm have been determined and discussed considering the case of the Periodic Sun-Synchronous Orbits.

  20. INCORPORATING AGILE WITH MDA CASE STUDY: ONLINE POLLING SYSTEM

    Directory of Open Access Journals (Sweden)

    Pritha Guha

    2011-11-01

    Full Text Available Nowadays agile software development is used in greater extend but for small organizations only, whereasMDA is suitable for large organizations but yet not standardized. In this paper the pros and cons ofModel Driven Architecture (MDA and Extreme programming have been discussed. As both of them havesome limitations and cannot be used in both large scale and small scale organizations a new architecturehas been proposed. In this model it is tried to opt the advantages and important values to overcome thelimitations of both the software development procedures. In support to the proposed architecture theimplementation of it on Online Polling System has been discussed and all the phases of softwaredevelopment have been explained.

  1. Attitude control for part actuator failure of agile small satellite

    Institute of Scientific and Technical Information of China (English)

    J. R. Zhang; A. Rachid; Y. Zhang

    2008-01-01

    The stability and singularity problem of agile small satellite (ASS) with actuator failure is discussed in this paper. Firstly, the three-axis stabilized controller of an ASS is designed, where micro control moment gyros (MCMG's) in pyramid configuration (PC) is used as the actuator. By using the same controller and steering law, the control results before and after one gyro fails are compared by simulation. The variation of singular momentum envelope before and after one gyro fails is also compared. The simulation results show that the failure intensively decreases the capacity of output torque, which leads to the emergence of more singular points and the rapid saturation of MCMG's. Finally, the parameters of system controller are changed to compare the control effect.

  2. Designing a Fuzzy Strategic Integrated Multiechelon Agile Supply Chain Network

    Directory of Open Access Journals (Sweden)

    Morteza Abbasi

    2013-01-01

    Full Text Available This paper integrates production, distribution and logistics activities at the strategic decision making level, where the objective is to design a multiechelon supply chain network considering agility as a key design criterion. A network with five echelons of supply chains including suppliers, plants, distribution centers, cross-docks, and customer zones is addressed in this paper. The problem has been mathematically formulated as a biobjective optimization model that aims to minimize the cost (fixed and variable and maximize the plant flexibility and volume flexibility. A novel multiobjective parallel simulating annealing algorithm (MOPSA is proposed to obtain the Pareto-optimal solutions of the problem. The performance of the proposed solution algorithm is compared with two well-known metaheuristics, namely, nondominated sorting genetic algorithm (NSGA-II and Pareto archive evolution strategy (PAES. Computational results show that MOPSA outperforms the other metaheuristics.

  3. Enhanced detection of terrestrial gamma-ray flashes by AGILE

    CERN Document Server

    Marisaldi, M; Ursi, A; Gjesteland, T; Fuschino, F; Labanti, C; Galli, M; Tavani, M; Pittori, C; Verrecchia, F; D'Amico, F; Østgaard, N; Mereghetti, S; Campana, R; Cattaneo, P W; Bulgarelli, A; Colafrancesco, S; Dietrich, S; Longo, F; Gianotti, F; Giommi, P; Rappoldi, A; Trifoglio, M; Trois, A

    2016-01-01

    At the end of March 2015 the onboard software configuration of the AGILE satellite was modified in order to disable the veto signal of the anticoincidence shield for the minicalorimeter instrument. The motivation for such a change was the understanding that the dead time induced by the anticoincidence prevented the detection of a large fraction of Terrestrial Gamma-Ray Flashes (TGFs). The configuration change was highly successful resulting in an increase of one order of magnitude in TGF detection rate. As expected, the largest fraction of the new events has short duration ($< 100 \\mathrm {\\mu s}$), and part of them has simultaneous association with lightning sferics detected by the World Wide Lightning Location Network (WWLLN). The new configuration provides the largest TGF detection rate surface density (TGFs/$\\mathrm{km^2}$/year) to date, opening prospects for improved correlation studies with lightning and atmospheric parameters on short spatial and temporal scales along the equatorial region.

  4. Agile Machining and Inspection Non-Nuclear Report (NNR) Project

    Energy Technology Data Exchange (ETDEWEB)

    Lazarus, Lloyd

    2009-02-19

    This report is a high level summary of the eight major projects funded by the Agile Machining and Inspection Non-Nuclear Readiness (NNR) project (FY06.0422.3.04.R1). The largest project of the group is the Rapid Response project in which the six major sub categories are summarized. This project focused on the operations of the machining departments that will comprise Special Applications Machining (SAM) in the Kansas City Responsive Infrastructure Manufacturing & Sourcing (KCRIMS) project. This project was aimed at upgrading older machine tools, developing new inspection tools, eliminating Classified Removable Electronic Media (CREM) in the handling of classified Numerical Control (NC) programs by installing the CRONOS network, and developing methods to automatically load Coordinated-Measuring Machine (CMM) inspection data into bomb books and product score cards. Finally, the project personnel leaned perations of some of the machine tool cells, and now have the model to continue this activity.

  5. Information Models, Data Requirements, and Agile Data Curation

    Science.gov (United States)

    Hughes, John S.; Crichton, Dan; Ritschel, Bernd; Hardman, Sean; Joyner, Ron

    2015-04-01

    The Planetary Data System's next generation system, PDS4, is an example of the successful use of an ontology-based Information Model (IM) to drive the development and operations of a data system. In traditional systems engineering, requirements or statements about what is necessary for the system are collected and analyzed for input into the design stage of systems development. With the advent of big data the requirements associated with data have begun to dominate and an ontology-based information model can be used to provide a formalized and rigorous set of data requirements. These requirements address not only the usual issues of data quantity, quality, and disposition but also data representation, integrity, provenance, context, and semantics. In addition the use of these data requirements during system's development has many characteristics of Agile Curation as proposed by Young et al. [Taking Another Look at the Data Management Life Cycle: Deconstruction, Agile, and Community, AGU 2014], namely adaptive planning, evolutionary development, early delivery, continuous improvement, and rapid and flexible response to change. For example customers can be satisfied through early and continuous delivery of system software and services that are configured directly from the information model. This presentation will describe the PDS4 architecture and its three principle parts: the ontology-based Information Model (IM), the federated registries and repositories, and the REST-based service layer for search, retrieval, and distribution. The development of the IM will be highlighted with special emphasis on knowledge acquisition, the impact of the IM on development and operations, and the use of shared ontologies at multiple governance levels to promote system interoperability and data correlation.

  6. DESIGNING DEPENDABLE AGILE LAYERED WEB SERVICES SECURITY ARCHITECTURE SOLUTIONS

    Directory of Open Access Journals (Sweden)

    M.UPENDRA KUMAR

    2011-06-01

    Full Text Available Service Orientation Engineering (SOE (using Web Services and Agile modeling software development presents promising solutions for contemporary software development projects to deal effectively withchallenges in increasingly turbulent business environments typified by unpredictable markets, changing customer requirements, pressures of even shorter time to deliver, and rapidly advancing informationtechnologies. Web Services Security Architectures have three layers, as provided by NIST standard: Web Service Layer, Web Services Framework Layer (.NET or J2EE, and Web Server Layer. In services oriented web services architecture, business processes are executed as a composition of services, which can suffer from vulnerabilities pertaining to secure data access and protecting code of Web Services. The goal of the Web services security architecture is to summary out the details of message-level security from the mainstream business logic, with a focus on Web Service contract design and versioning for SOA. Service oriented web services architectures impose additional analysis complexity as they provide much flexibility and frequentchanges with in orchestrated processes and services. In this paper, we discuss about developing dependable solutions for Web Services Security Architectures using Agile Layered security architectures in terms of Privacy requirements. All this research is motivated by Secure Service Oriented Analysis and Design research domain. We initially validate this by a BPEL Editor using GWT for RBAC and Privacy. Finally a real world case study is implemented using J2EE, for validating our approach. Secure Stock Exchange System using Web Services is to automate the stock exchange works, and can help user make the decisions when it comes to investment.

  7. A comparison of linear speed, closed-skill agility, and open-skill agility qualities between backcourt and frontcourt adult semiprofessional male basketball players.

    Science.gov (United States)

    Scanlan, Aaron T; Tucker, Patrick S; Dalbo, Vincent J

    2014-05-01

    The measurement of fitness qualities relevant to playing position is necessary to inform basketball coaching and conditioning staff of role-related differences in playing groups. To date, sprinting and agility performance have not been compared between playing positions in adult male basketball players. Therefore, the purpose of this study was to describe and compare linear speed, closed-skill agility, and open-skill agility qualities between backcourt (point guard and shooting guard positions) and frontcourt (small forward, power forward, and center positions) semiprofessional basketball players. Six backcourt (mean ± SD: age, 24.3 ± 7.9 years; stature, 183.4 ± 4.0 cm; body mass, 85.5 ± 12.3 kg; VO2max, 51.9 ± 4.8 ml·kg(-1)·min(-1)) and 6 frontcourt (mean ± SD: age, 27.5 ± 5.5 years; stature, 194.4 ± 7.1 cm; body mass, 109.4 ± 8.8 kg; VO2max, 47.1 ± 5.0 ml·kg(-1)·min(-1)) adult male basketball players completed 20-m sprint, closed-skill agility, and open-skill agility performance tests. Magnitude-based inferences revealed that backcourt players (5 m, 1.048 ± 0.027 seconds; 10 m, 1.778 ± 0.048 seconds; 20 m, 3.075 ± 0.121 seconds) possessed likely quicker linear sprint times than frontcourt players (5 m, 1.095 ± 0.085 seconds; 10 m, 1.872 ± 0.127 seconds; 20 m, 3.242 ± 0.221 seconds). Conversely, frontcourt players (1.665 ± 0.096 seconds) held possible superior closed-skill agility performance than backcourt players (1.613 ± 0.111 seconds). In addition, unclear positional differences were apparent for open-skill agility qualities. These findings indicate that linear speed and change of direction speed might be differently developed across playing positions. Furthermore, position-related functions might similarly depend on the aspects of open-skill agility performance across backcourt and frontcourt players. Basketball coaching and conditioning staff should consider the development of position-targeted training drills to improve speed, agility

  8. By using tissue chip technique to study the expression of p27 and cyclinE in breast carcinoma%采用组织芯片技术研究乳腺癌中p27和cyclinE的表达

    Institute of Scientific and Technical Information of China (English)

    戴艳枝; 刘勇; 袁晟; 邓宇

    2003-01-01

    To study the expressions of p27 ,cyclinE and analysis its meaning in breast carcinoma. Methods By using tissue chip technique creating 80 cases breast carcinoma tissue chip. at the same time using the S-P immunohis-tochemical methods, the expressions of p27 and cyclinE in breast carcinoma tissue chip was studied.Results The positive rates of p27 and cyclinE were 38.8% and 52.5% in 80 eases breast carcinoma respectively. A significant correlation was found between the lowexpression of p27, overexpression of cyclinE and metastasis of lymph node in breast carcinoma. A simaificant correlation was found be-tween the lowexpression of p27 and overexpression of cyclinE in breast carcinoma. Conclusion The expression of p27 and cyclinE might be considered to be a reference indicator for prognosis of breast carcinoma. The lowexpression of p27 has an ability to effect the overexpression of cyclinE in breast carcinoma. It is feasible to utilize tissue chip for a rapid, economic and accurate screening of clinical tissue specimens on a large scale.

  9. Agility Path Through Work Values in Knowledge-Based Organizations: A Study of Virtual Universities

    Directory of Open Access Journals (Sweden)

    Yashar Salamzadeh

    2014-05-01

    Full Text Available All people enter organizations with a formed personality and some initial experiences and values depending on the culture, which will, in turn, influence their efficiency and performance. Therefore, great attention must be paid to work values of the employees and the issues which affect them, especially in organizations that are complex in their structure and culture. Today’s dynamic environment requires organizations to be agile in their processes, with the issue being even more critical in knowledge-based organizations such as virtual universities. In this research, we identify the path through which organizations can achieve agility by means of work values. Although there are many dimensions in work values and organizational agility, using the methodology applied in this research, we omit some of these dimensions and find the best methods that will enable managers to wisely invest in the most important issues and get the best results in the path to achieve agility through work values.

  10. Entrepreneurial Call for Strategic Agility in Fast-Paced Business Environment

    Directory of Open Access Journals (Sweden)

    Arslan Ayub

    2014-06-01

    Full Text Available The 21st century came with blending of threats and opportunities of deep-rooted obstructions of fast-paced business environment. Research on strategic management has consequently increased and grabbed the attention of both academicians and strategic policy makers. The current study is therefore directed to analyze the multifaceted influence of entrepreneurial orientation on strategic agility and organizational performance. The study uses exploratory approach; primary data is collected from 323 professional working in private sectors in twin cities of Islamabad and Rawalpindi, Pakistan. The study found significantly positive relationship between entrepreneurial orientation and strategic agility, entrepreneurial orientation and organizational performance, and strategic agility and organizational performance. The study discusses important implications regarding entrepreneurs‘ deployment of entrepreneurial orientation and strategic agility for enhancing organizational performance.

  11. Transitioning from Distributed and Traditional to Distributed and Agile: An Experience Report

    Science.gov (United States)

    Wildt, Daniel; Prikladnicki, Rafael

    Global companies that experienced extensive waterfall phased plans are trying to improve their existing processes to expedite team engagement. Agile methodologies have become an acceptable path to follow because it comprises project management as part of its practices. Agile practices have been used with the objective of simplifying project control through simple processes, easy to update documentation and higher team iteration over exhaustive documentation, focusing rather on team continuous improvement and aiming to add value to business processes. The purpose of this chapter is to describe the experience of a global multinational company on transitioning from distributed and traditional to distributed and agile. This company has development centers across North America, South America and Asia. This chapter covers challenges faced by the project teams of two pilot projects, including strengths of using agile practices in a globally distributed environment and practical recommendations for similar endeavors.

  12. Agility in consumer retail: Sense-Response Alignment through the eyes of customers

    Directory of Open Access Journals (Sweden)

    Maura Atapattu

    2014-06-01

    Full Text Available In hyper competition, firms that are agile: sensing and responding better to customer requirements tend to be more successful and achieve supernormal profits. In spite of the widely accepted importance of customer agility, research is limited on this construct. The limited research also has predominantly focussed on the firm’s perspective of agility. However, we propose that the customers are better positioned to determine how well a firm is responding to their requirements (aka a firm’s customer agility. Taking the customers’ stand point, we address the issue of sense and respond alignment in two perspectives-matching and mediating. Based on data collected from customers in a field study, we tested hypothesis pertaining to the two methods of alignment using polynomial regression and response surface methodology. The results provide a good explanation for the role of both forms of alignment on customer satisfaction. Implication for research and practice are discussed.

  13. Improving the Management of Cost and Scope in Software Projects Using Agile Practices

    Directory of Open Access Journals (Sweden)

    Adriano Olimpio Tonelli

    2013-03-01

    Full Text Available While organizations want to develop software products with reduced cost and flexible scope, stories aboutthe applicability of agile practices to improve project development and performance in the softwareindustry are scarce and focused on specific methodologies such as Scrum and XP. Given these facts, thispaper aims to investigate, through practitioners' perceptions of value, which agile practices are being usedto improve two performance criteriafor software projects—cost and scope. Using a multivariate statisticaltechnique known as Exploratory Factor Analysis (EFA,the results suggest that the use of agile practicescan be represented infactors which describedifferent applicationsin software development processtoimprove cost and scope.Also, we conclude that some agile practices should be used together in order to getbetter efficiency on cost and scope in fourdevelopmentaspects: improving (a team abilities, (bmanagement of requirements, (c quality of the code developed, and (d delivery of software on-budget andon-time

  14. Integration of Lean and Agile Manufacturing Based on Principles from Wikinomics

    Directory of Open Access Journals (Sweden)

    Tatiana Ustyugová

    2013-07-01

    Full Text Available The purporse of this paper is to show the algorithm of the lean and agile manufacturing integration based on the principles from Wikinomics, which will lead to a steady production process and easier growth of company’s success. Lean and agile manufacturing are production concepts, which become more and more popular at the modern market. Nowadays we live at the period of possible, global communication, where the success of companies depends on customers’ satisfaction and the correct cost management. Therefore the principles from Wikinomics can be used like as integration method of lean and agile manufacturing. The originality of this paper lies in the creation of the new general algorithm of the lean and agile manufacturing integration was created, which will be used for the future research with special limitations of the Czech market. 

  15. Analysis of Return on Investment in Different Types of Agile Software Development Project Teams

    Directory of Open Access Journals (Sweden)

    Goran MILANOV

    2012-01-01

    Full Text Available This exploratory study of IT project teams in Serbia investigates how the choice of agile methods in different development project teams affects the return-on-investment (ROI. In this paper different types of software project teams are analyzed in order to examine and identify the business-value of using agile methods. In various software development project teams, the ROI of agile methods is yet to be fully explored, while the ROI of traditional methods is well-understood. Since ROI is important indicator of the projects success, in this paper we examine the factors that influence the ROI both from software solution customer point of view, and different agile project teams.

  16. Investigating Agile User-Centered Design in Practice: A Grounded Theory Perspective

    Science.gov (United States)

    Hussain, Zahid; Slany, Wolfgang; Holzinger, Andreas

    This paper investigates how the integration of agile methods and User-Centered Design (UCD) is carried out in practice. For this study, we have applied grounded theory as a suitable qualitative approach to determine what is happening in actual practice. The data was collected by semi-structured interviews with professionals who have already worked with an integrated agile UCD methodology. Further data was collected by observing these professionals in their working context, and by studying their documents, where possible. The emerging themes that the study found show that there is an increasing realization of the importance of usability in software development among agile team members. The requirements are emerging; and both low and high fidelity prototypes based usability tests are highly used in agile teams. There is an appreciation of each other's work from both UCD professionals and developers and both sides can learn from each other.

  17. Assimilation of Usability Engineering and User-Centered Design using Agile Software Development Approach

    Directory of Open Access Journals (Sweden)

    Hina Iqbal

    2014-10-01

    Full Text Available Various agile software development methodologies, since their commencement, encouraged the development of high quality software product. Quality of a product is the compelling trait that plays a vital role in any product's success. Usability engineering and User centered design are user-centered approaches, covering the customer's concerns. The way these approaches are understood and carried out with agile practices is not properly understood and adopted till now. For software applications to be usable and valuable it is necessary to understand the correct user requirements in order to develop the interface that is usable and valuable to the customer. In this research work, we are discussing the scrum approach of agile development and integrate this with the usability engineering and user centered design approaches which helps the agile development team to understand usability demand of users and develop a product according to their expectations.

  18. Explosive strength training improves speed and agility in wheelchair basketball athletes

    Directory of Open Access Journals (Sweden)

    Tarik Ozmen

    2014-04-01

    Full Text Available INTRODUCTION: Wheelchair basketball is a paralympic sport characterized by intermittent high-intensity activities that require explosive strength and speed. OBJECTIVE: To investigate the effect of explosive strength training on speed and agility performance in wheelchair basketball players. METHODS: Ten male wheelchair basketball players (Mage=31±4 yrs were divided into two groups [i.e. explosive strength training (ES; control (CN] based on International Wheelchair Basketball Federation (IWBF classification scores. The ES group underwent 6-weeks of training, twice weekly, at 50% 1RM, 10-12 repetitions and 3-4 sets in addition to routine training. Effects of training were measured by the 20 m sprint test and Illinois agility test. RESULTS: The ES group, showed significantly higher increases in speed and agility performance (p ≤ .05. CONCLUSION: A short-duration (i.e. 6-week explosive strength training programme in wheelchair basketball athletes results in significant improvements in sprint and agility performance.

  19. Experiment list: SRX271847 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ell type=Tonsillar naive B cells || treatment=NA || chip antibody=none || purification=Cells purified from normal fresh human tonsill...ectomy specimens by magnetic bead cell separation based on the expression the pheno

  20. Experiment list: SRX271845 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ll type=Tonsillar naive B cells || treatment=NA || chip antibody=none || purification=Cells purified from normal fresh human tonsille...ctomy specimens by magnetic bead cell separation based on the expression the phenot

  1. Acute effect of different stretching methods on Illinois agility test in soccer players.

    Science.gov (United States)

    Amiri-Khorasani, Mohammadtaghi; Sahebozamani, Mansour; Tabrizi, Kourosh G; Yusof, Ashril B

    2010-10-01

    The purpose of this study was to examine the effects of static, dynamic, and the combination of static and dynamic stretching within a pre-exercise warm-up on the Illinois agility test (IAT) in soccer players. Nineteen professional soccer players (age = 22.5 ± 2.5 years, height = 1.79 ± 0.003 m, body mass = 74.8 ± 10.9 kg) were tested for agility performance using the IAT after different warm-up protocols consisting of static, dynamic, combined stretching, and no stretching. The players were subgrouped into less and more experienced players (5.12 ± 0.83 and 8.18 ± 1.16 years, respectively). There were significant decreases in agility time after no stretching, among no stretching vs. static stretching; after dynamic stretching, among static vs. dynamic stretching; and after dynamic stretching, among dynamic vs. combined stretching during warm-ups for the agility: mean ± SD data were 14.18 ± 0.66 seconds (no stretch), 14.90 ± 0.38 seconds (static), 13.95 ± 0.32 seconds (dynamic), and 14.50 ± 0.35 seconds (combined). There was significant difference between less and more experienced players after no stretching and dynamic stretching. There was significant decrease in agility time following dynamic stretching vs. static stretching in both less and more experienced players. Static stretching does not appear to be detrimental to agility performance when combined with dynamic warm-up for professional soccer players. However, dynamic stretching during the warm-up was most effective as preparation for agility performance. The data from this study suggest that more experienced players demonstrate better agility skills due to years of training and playing soccer.

  2. Modeling of Agile Manufacturing Execution Systems with an Agent-based Approach

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Agile manufacturing execution systems (AMES) are used to help manufacturers optimize shop floor production in an agile way. And the modeling of AMES is the key issue of realizing AMES. This paper presents an agent-based approach to AMES modeling. Firstly, the characteristics of AMES and its requirements on modeling are discussed. Secondly, a comparative analysis of modeling methods is carried out, and AMES modeling using an agent-based approach is put forward. Agent-based modeling method not only inherit ...

  3. Project culture using Agile project management in hand with traditional project management

    OpenAIRE

    Sigurjón Páll Kolbeins 1965

    2013-01-01

    The Agile “revolution” within software development projects is changing how we do project management. This paper looks at the project management culture in one of the big three commercial banks in Iceland and how it has evolved the past 6 years. How stakeholders perceive project management through the lenses of those who sponsor projects, supply resources to projects, manage the projects and deliver the projects. The paper takes a look at how Agile project management has changed the cultu...

  4. Problems of Production Management in Agile Manufacturing Environment and their Countermeasures

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Agile manufacturing is a new production mode. This pa per discusses the four problems of production management in the environment of a gile manufacturing, and some countermeasures are advanced: (1) Organization of production. Traditional MTO production or MTS production ca n not meet the requirement of agile manufacturing which request both high produc tivity and the manufacturing flexibility. For this, the paper advances best way is to use the production organization mode of MCP (Mass Customization Pro...

  5. 敏捷服务工程标准%Criteria for an Agile Service Engineering

    Institute of Scientific and Technical Information of China (English)

    Helmut Aschbacher; Gerald Lichtenegger; Siegfried Voessner; Stefan Gruenwald; Ernst Kreuzer

    2009-01-01

    Similar to the software industry there are different models for the development,testing and management of services described in literature.The authors of this paper discuss the term of agility.show the boundaries of the Service Engineering proceedings described in literature,show how organizations are in permanent change and development and how this will influence the Service Engineering processes.Furthermore a theoretical design of an agile method for Service Engineering is presented.

  6. The effect of quality of electronic banking services on agility of a bank

    OpenAIRE

    Hooman Pourmohammad; Mostafa Zandieh; Hasan Farsijani

    2016-01-01

    Studies have shown that in service organizations, quality can have a growth in customer satisfaction as its consequence, and when it regards the banking services, factors are brought up with regard to the quality of banking services, which include the speed in responding, providing products proportionate to the customer needs, and gaining competence. These concepts are shared by the issue of organizational agility; hence, the qualities as well as the bank's agility of the banking system embra...

  7. 基因芯片技术研究虚寒证大鼠肝全基因表达谱%Study of Gene Chip Technology on Whole Genome Expression of Liver of Rats with Asthenia Cold Syndrome

    Institute of Scientific and Technical Information of China (English)

    韩冰冰; 王世军; 于华芸; 赵海军; 王媛

    2011-01-01

    Objective;To study the whole genome expression of liver on asthenia cold syndrome rats by gene chip technology. Methods:The Asthenia cold syndrome rats models were induced by compound preparation of traditional Chinese medicine of Raw Gypsum,Radix gentianae、Cortex Phellodendri 、Anemarrhenae Rhizoma.The liver gene expression in each group was detected by gene chip. We selected the differential expression genes and conducted the significant analysis on the genetic function of differential genes. A part of genes were selected to test the accuracy of results by RT - PCR. Results: As compared to the control group,in asthenia cold model group there were 99 strips of differential expression gene, mainly about function of response to stimulus. Conclusion ; Many strips of gene about response to stimulus were down - regulated in asthenia cold syndrome rats, which induced down regulation of function about immune response,defense response,response to other organism. The substance foundation of asthenia cold syndrome was possibly related to these genes.%目的:采用基因芯片技术研究虚寒证大鼠肝全基因表达谱的改变.方法:使用中药复方生石膏、龙胆草、黄柏和知母建立虚寒证大鼠模型,应用基因芯片检测各组大鼠肝脏基因表达,筛选差异表达基因,进行基因功能分类注释.荧光定量PCR验证芯片结果.结果:虚寒模型组与空白对照组比较有99条基因差异表达,主要涉及刺激应答功能.结论:虚寒证可能通过多种刺激应答相关基因的下调,导致免疫应答功能、防御应答功能及对其他生物体刺激应答功能的降低.虚寒证的物质基础可能与此类基因的异常表达相关.

  8. Incidence of Complications During Initial Experience with Revision of the Agility and Agility LP Total Ankle Replacement Systems: A Single Surgeon's Learning Curve Experience.

    Science.gov (United States)

    Roukis, Thomas S; Simonson, Devin C

    2015-10-01

    As the frequency in which foot and ankle surgeons are performing primary total ankle replacement (TAR) continues to build, revision TAR will likely become more commonplace, creating a need for an established benchmark by which to evaluate the safety of revision TAR as determined by the incidence of complications. Currently, no published data exist on the incidence of intraoperative and early postoperative complications during revision of the Agility or Agility LP Total Ankle Replacement Systems during the surgeon learning curve period; therefore, the authors sought to determine this incidence during the senior author's learning curve period.

  9. A systematic review of the main factors that determine agility in sport using structural equation modeling.

    Science.gov (United States)

    Hojka, Vladimir; Stastny, Petr; Rehak, Tomas; Gołas, Artur; Mostowik, Aleksandra; Zawart, Marek; Musálek, Martin

    2016-09-01

    While tests of basic motor abilities such as speed, maximum strength or endurance are well recognized, testing of complex motor functions such as agility remains unresolved in current literature. Therefore, the aim of this review was to evaluate which main factor or factor structures quantitatively determine agility. In methodological detail, this review focused on research that explained or described the relationships between latent variables in a factorial model of agility using approaches such as principal component analysis, factor analysis and structural equation modeling. Four research studies met the defined inclusion criteria. No quantitative empirical research was found that tried to verify the quality of the whole suggested model of the main factors determining agility through the use of a structural equation modeling (SEM) approach or a confirmatory factor analysis. From the whole structure of agility, only change of direction speed (CODS) and some of its subtests were appropriately analyzed. The combination of common CODS tests is reliable and useful to estimate performance in sub-elite athletes; however, for elite athletes, CODS tests must be specific to the needs of a particular sport discipline. Sprinting and jumping tests are stronger factors for CODS than explosive strength and maximum strength tests. The authors suggest the need to verify the agility factorial model by a second generation data analysis technique such as SEM.

  10. Adopting best practices: "Agility" moves from software development to healthcare project management.

    Science.gov (United States)

    Kitzmiller, Rebecca; Hunt, Eleanor; Sproat, Sara Breckenridge

    2006-01-01

    It is time for a change in mindset in how nurses operationalize system implementations and manage projects. Computers and systems have evolved over time from unwieldy mysterious machines of the past to ubiquitous computer use in every aspect of daily lives and work sites. Yet, disconcertingly, the process used to implement these systems has not evolved. Technology implementation does not need to be a struggle. It is time to adapt traditional plan-driven implementation methods to incorporate agile techniques. Agility is a concept borrowed from software development and is presented here because it encourages flexibility, adaptation, and continuous learning as part of the implementation process. Agility values communication and harnesses change to an advantage, which facilitates the natural evolution of an adaptable implementation process. Specific examples of agility in an implementation are described, and plan-driven implementation stages are adapted to incorporate relevant agile techniques. This comparison demonstrates how an agile approach enhances traditional implementation techniques to meet the demands of today's complex healthcare environments.

  11. CHIP Reporting in the CPS

    Data.gov (United States)

    U.S. Department of Health & Human Services — CHIP reporting in the CPS is unreliable. Only 10 to 30 percent of those with CHIP (but not Medicaid) report this type of coverage in the CPS. Many with CHIP report...

  12. Agile data management for curation of genomes to watershed datasets

    Science.gov (United States)

    Varadharajan, C.; Agarwal, D.; Faybishenko, B.; Versteeg, R.

    2015-12-01

    A software platform is being developed for data management and assimilation [DMA] as part of the U.S. Department of Energy's Genomes to Watershed Sustainable Systems Science Focus Area 2.0. The DMA components and capabilities are driven by the project science priorities and the development is based on agile development techniques. The goal of the DMA software platform is to enable users to integrate and synthesize diverse and disparate field, laboratory, and simulation datasets, including geological, geochemical, geophysical, microbiological, hydrological, and meteorological data across a range of spatial and temporal scales. The DMA objectives are (a) developing an integrated interface to the datasets, (b) storing field monitoring data, laboratory analytical results of water and sediments samples collected into a database, (c) providing automated QA/QC analysis of data and (d) working with data providers to modify high-priority field and laboratory data collection and reporting procedures as needed. The first three objectives are driven by user needs, while the last objective is driven by data management needs. The project needs and priorities are reassessed regularly with the users. After each user session we identify development priorities to match the identified user priorities. For instance, data QA/QC and collection activities have focused on the data and products needed for on-going scientific analyses (e.g. water level and geochemistry). We have also developed, tested and released a broker and portal that integrates diverse datasets from two different databases used for curation of project data. The development of the user interface was based on a user-centered design process involving several user interviews and constant interaction with data providers. The initial version focuses on the most requested feature - i.e. finding the data needed for analyses through an intuitive interface. Once the data is found, the user can immediately plot and download data

  13. Chip Multithreaded Consistency Model

    Institute of Scientific and Technical Information of China (English)

    Zu-Song Li; Dan-Dan Huan; Wei-Wu Hu; Zhi-Min Tang

    2008-01-01

    Multithreaded technique is the developing trend of high performance processor. Memory consistency model is essential to the correctness, performance and complexity of multithreaded processor. The chip multithreaded consistency model adapting to multithreaded processor is proposed in this paper. The restriction imposed on memory event ordering by chip multithreaded consistency is presented and formalized. With the idea of critical cycle built by Wei-Wu Hu, we prove that the proposed chip multithreaded consistency model satisfies the criterion of correct execution of sequential consistency model. Chip multithreaded consistency model provides a way of achieving high performance compared with sequential consistency model and ensures the compatibility of software that the execution result in multithreaded processor is the same as the execution result in uniprocessor. The implementation strategy of chip multithreaded consistency model in Godson-2 SMT processor is also proposed. Godson-2 SMT processor supports chip multithreaded consistency model correctly by exception scheme based on the sequential memory access queue of each thread.

  14. MiniMAX: miniature, mobile, agile, x-ray system

    Science.gov (United States)

    Watson, Scott A.; Cunningham, Gwynneth; Gonzales, Samuel

    2012-06-01

    We present a unique, lightweight, compact, low-cost, x-ray imager: MiniMAX (Miniature, Mobile, Agile, X-ray). This system, which exploits the best aspects of Computed Radiography (CR) and Digital Radiography (DR) technology, weighs less than 6lbs, fits into a 6" diameter x 16" long carbon-fiber tube, and is constructed almost entirely from offthe- shelf components. MiniMAX is suitable for use in weld inspection, archaeology, homeland security, and veterinary medicine. While quantum limited for MeV radiography, the quantum-efficiency is too low for routine medical use. Formats include: 4"x6", 8"x12", or 16"x24" and can be readily displayed on the camera back, using a pocket projector, or on a tablet computer. In contrast to a conventional, flying-spot scanner, MiniMAX records a photostimulated image from the entire phosphor at once using a bright, red LED flash filtered through an extremely efficient (OD>9) dichroic filter.

  15. Autonomous, agile micro-satellites and supporting technologies

    Energy Technology Data Exchange (ETDEWEB)

    Breitfeller, E; Dittman, M D; Gaughan, R J; Jones, M S; Kordas, J F; Ledebuhr, A G; Ng, L C; Whitehead, J C; Wilson, B

    1999-07-19

    This paper updates the on-going effort at Lawrence Livermore National Laboratory to develop autonomous, agile micro-satellites (MicroSats). The objective of this development effort is to develop MicroSats weighing only a few tens of kilograms, that are able to autonomously perform precision maneuvers and can be used telerobotically in a variety of mission modes. The required capabilities include satellite rendezvous, inspection, proximity-operations, docking, and servicing. The MicroSat carries an integrated proximity-operations sensor-suite incorporating advanced avionics. A new self-pressurizing propulsion system utilizing a miniaturized pump and non-toxic mono-propellant hydrogen peroxide was successfully tested. This system can provide a nominal 25 kg MicroSat with 200-300 m/s delta-v including a warm-gas attitude control system. The avionics is based on the latest PowerPC processor using a CompactPCI bus architecture, which is modular, high-performance and processor-independent. This leverages commercial-off-the-shelf (COTS) technologies and minimizes the effects of future changes in processors. The MicroSat software development environment uses the Vx-Works real-time operating system (RTOS) that provides a rapid development environment for integration of new software modules, allowing early integration and test. We will summarize results of recent integrated ground flight testing of our latest non-toxic pumped propulsion MicroSat testbed vehicle operated on our unique dynamic air-rail.

  16. Commissioning the CERN IT Agile Infrastructure with experiment workloads

    CERN Document Server

    Medrano Llamas, Ramón; Kucharczyk, Katarzyna; Denis, Marek Kamil; Cinquilli, Mattia

    2014-01-01

    In order to ease the management of their infrastructure, most of the WLCG sites are adopting cloud based strategies. In the case of CERN, the Tier 0 of the WLCG, is completely restructuring the resource and configuration management of their computing center under the codename Agile Infrastructure. Its goal is to manage 15,000 Virtual Machines by means of an OpenStack middleware in order to unify all the resources in CERN's two datacenters: the one placed in Meyrin and the new on in Wigner, Hungary. During the commissioning of this infrastructure, CERN IT is offering an attractive amount of computing resources to the experiments (800 cores for ATLAS and CMS) through a private cloud interface. ATLAS and CMS have joined forces to exploit them by running stress tests and simulation workloads since November 2012. This work will describe the experience of the first deployments of the current experiment workloads on the CERN private cloud testbed. The paper is organized as follows: the first section will explain th...

  17. SBIR Grant:No-Vibration Agile Cryogenic Optical Refrigerator

    Energy Technology Data Exchange (ETDEWEB)

    Epstein, Richard

    2013-04-09

    Optical refrigeration is currently the only all-solid-state cryocooling technology that has been demonstrated. Optical cryocoolers are devices that use laser light to cool small crystal or glass cooling elements. The cooling element absorbs the laser light and reradiates it at higher energy, an example of anti-Stokes fluorescence. The dif-ference between the energy of the outgoing and incoming light comes from the thermal energy of the cooling element, which in turn becomes colder. Entitled No-Vibration Agile Cryocoolers using Optical Refrigeration, this Phase I proposal directly addressed the continued development of the optical refrigerator components necessary to transition this scientific breakthrough into National Nu-clear Security Administration (NNSA) sensor applications in line with the objectives of topic 50b. ThermoDynamic Films LLC (TDF), in collaboration with the University of New Mexico (UNM), cooled an optical-refrigerator cooling element comprised of an ytterbium-doped yttrium lithium fluoride (Yb:YLF) crystal from room tempera-ture to 123 K with about 2% efficiency. This is the world record in optical refrigera-tion and an important step toward revolutionizing cryogenic systems for sensor ap-plications. During this period, they also designed and analyzed the crucial elements of a prototype optical refrigerator including the thermal link that connects the cool-ing element with the load.

  18. Patency(C) and agile(C) capsules

    Institute of Scientific and Technical Information of China (English)

    àngel Caunedo-àlvarez; Javier Romero-Vazquez; Juan M Herrerias-Gutierrez

    2008-01-01

    Small bowel strictures can be missed by current diagnostic methods.The Patency capsule is a new non-endoscopic dissolvable capsule which has as an objective of checking the patency of digestive tract,in a non-invasive manner.The available clinical trials have demonstrated that the Patency(C) capsule is a good tool for assessment of the functional patency of the small bowel,and it allows identification of those patients who can safely undergo a capsule endoscopy,despite clinical and radiographic evidence of small-bowel obstruction.Some cases of intestinal occlusion have been reported with the Patency(C) capsule,four of them needed surgery.So,a new capsule with two timer plugs (Agile(C) capsule) has been recently developed in order to minimize the risk of occlusion.This new device stars its dissolution process earlier (30 h after ingestion) and its two timer plugs have been designed to begin the disintegration even when the device is blocked in a tight stricture.

  19. Function-based integration strategy for an agile manufacturing testbed

    Science.gov (United States)

    Park, Hisup

    1997-01-01

    This paper describes an integration strategy for plug-and- play software based on functional descriptions of the software modules. The functional descriptions identify explicitly the role of each module with respect to the overall systems. They define the critical dependencies that affect the individual modules and thus affect the behavior of the system. The specified roles, dependencies and behavioral constraints are then incorporated in a group of shared objects that are distributed over a network. These objects may be interchanged with others without disrupting the system so long as the replacements meet the interface and functional requirements. In this paper, we propose a framework for modeling the behavior of plug-and-play software modules that will be used to (1) design and predict the outcome of the integration, (2) generate the interface and functional requirements of individual modules, and (3) form a dynamic foundation for applying interchangeable software modules. I describe this strategy in the context of the development of an agile manufacturing testbed. The testbed represents a collection of production cells for machining operations, supported by a network of software modules or agents for planning, fabrication, and inspection. A process definition layer holds the functional description of the software modules. A network of distributed objects interact with one another over the Internet and comprise the plug-compatible software nodes that execute these functions. This paper will explore the technical and operational ramifications of using the functional description framework to organize and coordinate the distributed object modules.

  20. Commissioning the CERN IT Agile Infrastructure with experiment workloads

    Science.gov (United States)

    Medrano Llamas, Ramón; Harald Barreiro Megino, Fernando; Kucharczyk, Katarzyna; Kamil Denis, Marek; Cinquilli, Mattia

    2014-06-01

    In order to ease the management of their infrastructure, most of the WLCG sites are adopting cloud based strategies. In the case of CERN, the Tier 0 of the WLCG, is completely restructuring the resource and configuration management of their computing center under the codename Agile Infrastructure. Its goal is to manage 15,000 Virtual Machines by means of an OpenStack middleware in order to unify all the resources in CERN's two datacenters: the one placed in Meyrin and the new on in Wigner, Hungary. During the commissioning of this infrastructure, CERN IT is offering an attractive amount of computing resources to the experiments (800 cores for ATLAS and CMS) through a private cloud interface. ATLAS and CMS have joined forces to exploit them by running stress tests and simulation workloads since November 2012. This work will describe the experience of the first deployments of the current experiment workloads on the CERN private cloud testbed. The paper is organized as follows: the first section will explain the integration of the experiment workload management systems (WMS) with the cloud resources. The second section will revisit the performance and stress testing performed with HammerCloud in order to evaluate and compare the suitability for the experiment workloads. The third section will go deeper into the dynamic provisioning techniques, such as the use of the cloud APIs directly by the WMS. The paper finishes with a review of the conclusions and the challenges ahead.

  1. Agile multi-scale decompositions for automatic image registration

    Science.gov (United States)

    Murphy, James M.; Leija, Omar Navarro; Le Moigne, Jacqueline

    2016-05-01

    In recent works, the first and third authors developed an automatic image registration algorithm based on a multiscale hybrid image decomposition with anisotropic shearlets and isotropic wavelets. This prototype showed strong performance, improving robustness over registration with wavelets alone. However, this method imposed a strict hierarchy on the order in which shearlet and wavelet features were used in the registration process, and also involved an unintegrated mixture of MATLAB and C code. In this paper, we introduce a more agile model for generating features, in which a flexible and user-guided mix of shearlet and wavelet features are computed. Compared to the previous prototype, this method introduces a flexibility to the order in which shearlet and wavelet features are used in the registration process. Moreover, the present algorithm is now fully coded in C, making it more efficient and portable than the mixed MATLAB and C prototype. We demonstrate the versatility and computational efficiency of this approach by performing registration experiments with the fully-integrated C algorithm. In particular, meaningful timing studies can now be performed, to give a concrete analysis of the computational costs of the flexible feature extraction. Examples of synthetically warped and real multi-modal images are analyzed.

  2. Sandia Agile MEMS Prototyping, Layout Tools, Education and Services Program

    Energy Technology Data Exchange (ETDEWEB)

    Schriner, H.; Davies, B.; Sniegowski, J.; Rodgers, M.S.; Allen, J.; Shepard, C.

    1998-05-01

    Research and development in the design and manufacture of Microelectromechanical Systems (MEMS) is growing at an enormous rate. Advances in MEMS design tools and fabrication processes at Sandia National Laboratories` Microelectronics Development Laboratory (MDL) have broadened the scope of MEMS applications that can be designed and manufactured for both military and commercial use. As improvements in micromachining fabrication technologies continue to be made, MEMS designs can become more complex, thus opening the door to an even broader set of MEMS applications. In an effort to further research and development in MEMS design, fabrication, and application, Sandia National Laboratories has launched the Sandia Agile MEMS Prototyping, Layout Tools, Education and Services Program or SAMPLES program. The SAMPLES program offers potential partners interested in MEMS the opportunity to prototype an idea and produce hardware that can be used to sell a concept. The SAMPLES program provides education and training on Sandia`s design tools, analysis tools and fabrication process. New designers can participate in the SAMPLES program and design MEMS devices using Sandia`s design and analysis tools. As part of the SAMPLES program, participants` designs are fabricated using Sandia`s 4 level polycrystalline silicon surface micromachine technology fabrication process known as SUMMiT (Sandia Ultra-planar, Multi-level MEMS Technology). Furthermore, SAMPLES participants can also opt to obtain state of the art, post-fabrication services provided at Sandia such as release, packaging, reliability characterization, and failure analysis. This paper discusses the components of the SAMPLES program.

  3. UW VLSI chip tester

    Science.gov (United States)

    McKenzie, Neil

    1989-12-01

    We present a design for a low-cost, functional VLSI chip tester. It is based on the Apple MacIntosh II personal computer. It tests chips that have up to 128 pins. All pin drivers of the tester are bidirectional; each pin is programmed independently as an input or an output. The tester can test both static and dynamic chips. Rudimentary speed testing is provided. Chips are tested by executing C programs written by the user. A software library is provided for program development. Tests run under both the Mac Operating System and A/UX. The design is implemented using Xilinx Logic Cell Arrays. Price/performance tradeoffs are discussed.

  4. Effects of ankle braces upon agility course performance in high school athletes.

    Science.gov (United States)

    Beriau, M R; Cox, W B; Manning, J

    1994-09-01

    The purpose of this study was to compare the effects of wearing the Aircast(TM) Sports Stirrup, Aircast(TM) Training brace, Swede-O(TM) brace, and DonJoy(TM) Ankle Ligament Protector while running an agility course. Eighty-five high school athletes with no history of ankle injury and no experience in wearing any ankle support served as subjects. Each subject participated in four separate testing sessions. During sessions 1 and 4, subjects ran the agility course under the control (unbraced) conditions. Sessions 2 and 3 consisted of randomly wearing the ankle braces while running the agility course. A questionnaire concerning support, comfort, and restriction was completed by each subject after wearing each of the braces. An analysis of variance (ANOVA) with repeated measures revealed that a significant difference existed between the agility times. Tukey's post hoc test indicated that a significant difference existed between each ankle brace and the control 2 agility times as well as a control 1 and control 2 time difference. The control time difference was attributed to a learning effect. An ANOVA with repeated measures of only the four braces revealed that a significant difference existed between the agility times. Tukey's post hoc test showed the only difference was between the DonJoy Ankle Ligament Protector and the Aircast Training brace. We concluded: 1) there is limited practical performance effect upon agility while wearing an ankle brace; and 2) an athlete's perceived comfort, support, and performance restriction are contributing factors that may directly influence the effectiveness of ankle bracing.

  5. Screening of differentially expressed genes related to artery calcification in rats by gene chip technology%利用基因芯片筛选动脉钙化大鼠差异表达基因

    Institute of Scientific and Technical Information of China (English)

    卢海林; 韦肖敏; 蒋汶洪; 胡明; 杨晗; 覃晓

    2016-01-01

    目的:利用基因芯片技术筛选正常大鼠和动脉钙化大鼠腹主动脉组织中差异表达基因及检测转化生长因子-β(TGF-β)、基质金属蛋白酶-2(MMP-2)和基质金属蛋白酶-9(MMP-9)的表达量,以探讨动脉钙化发病的可能机制。方法通过皮下注射大剂量维生素D3建立大鼠动脉钙化模型,采用Von Kossa染色观察动脉钙化程度,基因芯片技术筛选两组大鼠差异表达基因及检测TGF-β、MMP-2和MMP-9的表达量。结果与对照组相比,模型组差异表达的基因有710条,其中上调基因344条,下调基因366条。模型组TGF -β1、TGF-β3和MMP-2的表达均明显上调,差异具有统计学意义(P<0.05),而TGF-β2和MMP-9的表达则无明显差异(P>0.05)。结论动脉钙化的形成是多基因共同作用的结果,其中TGF-β、MMP-2和MMP-9对动脉钙化的发生发展起着至关重要的作用,其机制还有待进一步研究。%Objective To investigate the possible mechanism of arterial calcification by screening differentially expressed genes and detecting the expression levels of transforming growth factor beta ( TGF-β) , matrix metalloprotein-ase-2 ( MMP-2 ) and matrix metalloproteinase-9 ( MMP-9 ) between normal rats and rats with artery calcification through gene chip technology.Methods Arterial calcification in rats was induced by subcutaneous injection of large dose of vitamin D3 .The extent of artery calcification was determined by Von Kossa staining.Differentially expressed genes and the expression levels of TGF-β, MMP-2 and MMP-9 between normal rats and rats with arterial calcification were de-tected through gene chip technology.Results Compared with the control group, 710 genes were differentially expressed in the model group.344 were up-regulated and 366 were down-regulated.Expression levels of TGF-β1, TGF-β3, and MMP-2 in the model group were significantly up-regulated ( P

  6. Sport performance and agility tests Sporda performans ve çeviklik testleri

    Directory of Open Access Journals (Sweden)

    Kursat Karacabey

    2013-06-01

    Full Text Available The purpose of this study is to examine the effect agility on sports performance and agility measurement tests. Agility is described as a rapid whole body movement with change of velocity or direction in response to a stimulus. Good agility requires a combination of speed, balance, power and co-ordination. Agility, which is a motoric ability, can be improved by regular progressive exercise. As an important component, agility is used to be an acceptable method in sports performance test batteries. As a result of the study; agility, which is a required characteristic in most of the sports activities, is a quality that successful athletes should have. While administering the sports performance test batteries to enhance sports performance both the exercise to improve agility and to develop dynamic balance that support agility has importance. Özet Bu çalışmanın amacı çevikliğin spor performansına etkisini ve çeviklik ölçüm testlerini incelemektir. Çeviklik, belli bir uyarıcıya cevap olarak tüm vücudun hız veya yön değiştirerek ani hareketi olarak tanımlanır. Çevikliğin kalitesi, hız, denge, güç ve koordinasyonun ortaklığını gerektirir. Motor bir yetenek olan çeviklik, düzenli progresif egzersizle geliştirilebilir. Önemli bir unsur olarak çeviklik spor performans ölçüm bataryalarında kullanılan geçerli bir yöntemdir. Çalışmanın sonucu olarak, spor aktivitelerinin büyük çoğunluğunda gerekli bir özellik olan çeviklik, başarılı sporcuların sahip olması gereken önemli bir niteliktir. Sportif performansın artırılması için sportif performans testleri uygulanırken hem çevikliği arttırıcı egzersizler hem de çevikliğin artmasını sağlayan dinamik denge özelliğini de geliştirici egzersizler öneme sahiptir.

  7. Agile enterprise development framework utilizing services principles for building pervasive security

    Science.gov (United States)

    Farroha, Deborah; Farroha, Bassam

    2011-06-01

    We are in an environment of continuously changing mission requirements and therefore our Information Systems must adapt to accomplish new tasks, quicker, in a more proficient manner. Agility is the only way we will be able to keep up with this change. But there are subtleties that must be considered as we adopt various agile methods: secure, protect, control and authenticate are all elements needed to posture our Information Technology systems to counteract the real and perceived threats in today's environment. Many systems have been tasked to ingest process and analyze different data sets than they were originally designed for and they have to interact with multiple new systems that were unaccounted for at design time. Leveraging the tenets of security, we have devised a new framework that takes agility into a new realm where the product will built to work in a service-based environment but is developed using agile processes. Even though these two criteria promise to hone the development effort, they actually contradict each other in philosophy where Services require stable interfaces, while Agile focuses on being flexible and tolerate changes up to much later stages of development. This framework is focused on enabling a successful product development that capitalizes on both philosophies.

  8. Developing a model for agile supply: an empirical study from Iranian pharmaceutical supply chain.

    Science.gov (United States)

    Rajabzadeh Ghatari, Ali; Mehralian, Gholamhossein; Zarenezhad, Forouzandeh; Rasekh, Hamid Reza

    2013-01-01

    Agility is the fundamental characteristic of a supply chain needed for survival in turbulent markets, where environmental forces create additional uncertainty resulting in higher risk in the supply chain management. In addition, agility helps providing the right product, at the right time to the consumer. The main goal of this research is therefore to promote supplier selection in pharmaceutical industry according to the formative basic factors. Moreover, this paper can configure its supply network to achieve the agile supply chain. The present article analyzes the supply part of supply chain based on SCOR model, used to assess agile supply chains by highlighting their specific characteristics and applicability in providing the active pharmaceutical ingredient (API). This methodology provides an analytical modeling; the model enables potential suppliers to be assessed against the multiple criteria using both quantitative and qualitative measures. In addition, for making priority of critical factors, TOPSIS algorithm has been used as a common technique of MADM model. Finally, several factors such as delivery speed, planning and reorder segmentation, trust development and material quantity adjustment are identified and prioritized as critical factors for being agile in supply of API.

  9. Acute Effects of Static and Dynamic Stretching on Balance, Agility, Reaction Time and Movement Time

    Directory of Open Access Journals (Sweden)

    Dimitris Chatzopoulos

    2014-06-01

    Full Text Available The purpose of this study was to compare the acute effects of three different stretching protocols on balance, agility, reaction time and movement time of the upper limbs. Participants were thirty one female high school athletes (age = 17.3 ± 0.5 yr.. All participants performed one of the following protocols on different days: (a 3 min jogging followed by 7 min static stretching (SS, (b 3 min jogging followed by 7 min dynamic stretching (DS, and (c 3 min jogging followed by 7 min of rest (NS. After the protocols participants performed the following tests: dynamic balance, 505 agility test, reaction time (time between a sound stimulus and release of a button and movement time (movement of the upper extremity over a 0.5 m distance. The order of stretching protocols and performance tests were counterbalanced to avoid carryover effects. Repeated measures analysis of variance revealed significant main effects for all variables except reaction time. The DS protocol compared to SS performed significantly better in balance, agility and movement time. Additionally, the DS protocol compared to NS performed significantly better in agility. According to the results of the study, a DS protocol is more appropriate than SS for activities that require balance, rapid change of running direction (agility and movement time of the upper extremities.

  10. A SECURITY EVALUATION FRAMEWORK FOR U.K. E-GOVERNMENT SERVICES AGILE SOFTWARE DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Steve Harrison

    2016-03-01

    Full Text Available This study examines the traditional approach to software development within the United Kingdom Government and the accreditation process. Initially we look at the Waterfall methodology that has been used for several years. We discuss the pros and cons of Waterfall before moving onto the Agile Scrum methodology. Agile has been adopted by the majority of Government digital departments including the Government Digital Services. Agile, despite its ability to achieve high rates of productivity organized in short, flexible, iterations, has faced security professionals’ disbelief when working within the U.K. Government. One of the major issues is that we develop in Agile but the accreditation process is conducted using Waterfall resulting in delays to go live dates. Taking a brief look into the accreditation process that is used within Government for I.T. systems and applications, we focus on giving the accreditor the assurance they need when developing new applications and systems. A framework has been produced by utilising the Open Web Application Security Project’s (OWASP Application Security Verification Standard (ASVS. This framework will allow security and Agile to work side by side and produce secure code.

  11. Array Databases: Agile Analytics (not just) for the Earth Sciences

    Science.gov (United States)

    Baumann, P.; Misev, D.

    2015-12-01

    Gridded data, such as images, image timeseries, and climate datacubes, today are managed separately from the metadata, and with different, restricted retrieval capabilities. While databases are good at metadata modelled in tables, XML hierarchies, or RDF graphs, they traditionally do not support multi-dimensional arrays.This gap is being closed by Array Databases, pioneered by the scalable rasdaman ("raster data manager") array engine. Its declarative query language, rasql, extends SQL with array operators which are optimized and parallelized on server side. Installations can easily be mashed up securely, thereby enabling large-scale location-transparent query processing in federations. Domain experts value the integration with their commonly used tools leading to a quick learning curve.Earth, Space, and Life sciences, but also Social sciences as well as business have massive amounts of data and complex analysis challenges that are answered by rasdaman. As of today, rasdaman is mature and in operational use on hundreds of Terabytes of timeseries datacubes, with transparent query distribution across more than 1,000 nodes. Additionally, its concepts have shaped international Big Data standards in the field, including the forthcoming array extension to ISO SQL, many of which are supported by both open-source and commercial systems meantime. In the geo field, rasdaman is reference implementation for the Open Geospatial Consortium (OGC) Big Data standard, WCS, now also under adoption by ISO. Further, rasdaman is in the final stage of OSGeo incubation.In this contribution we present array queries a la rasdaman, describe the architecture and novel optimization and parallelization techniques introduced in 2015, and put this in context of the intercontinental EarthServer initiative which utilizes rasdaman for enabling agile analytics on Petascale datacubes.

  12. Agile beam laser radar using computational imaging for robotic perception

    Science.gov (United States)

    Powers, Michael A.; Stann, Barry L.; Giza, Mark M.

    2015-05-01

    This paper introduces a new concept that applies computational imaging techniques to laser radar for robotic perception. We observe that nearly all contemporary laser radars for robotic (i.e., autonomous) applications use pixel basis scanning where there is a one-to-one correspondence between world coordinates and the measurements directly produced by the instrument. In such systems this is accomplished through beam scanning and/or the imaging properties of focal-plane optics. While these pixel-basis measurements yield point clouds suitable for straightforward human interpretation, the purpose of robotic perception is the extraction of meaningful features from a scene, making human interpretability and its attendant constraints mostly unnecessary. The imposing size, weight, power and cost of contemporary systems is problematic, and relief from factors that increase these metrics is important to the practicality of robotic systems. We present a system concept free from pixel basis sampling constraints that promotes efficient and adaptable sensing modes. The cornerstone of our approach is agile and arbitrary beam formation that, when combined with a generalized mathematical framework for imaging, is suited to the particular challenges and opportunities of robotic perception systems. Our hardware concept looks toward future systems with optical device technology closely resembling modern electronically-scanned-array radar that may be years away from practicality. We present the design concept and results from a prototype system constructed and tested in a laboratory environment using a combination of developed hardware and surrogate devices for beam formation. The technological status and prognosis for key components in the system is discussed.

  13. ALICE chip processor

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    This tiny chip provides data processing for the time projection chamber on ALICE. Known as the ALICE TPC Read Out (ALTRO), this device was designed to minimize the size and power consumption of the TPC front end electronics. This single chip contains 16 low-power analogue-to-digital converters with six million transistors of digital processing and 8 kbits of data storage.

  14. Expression

    Directory of Open Access Journals (Sweden)

    Wang-Xia Wang

    2014-02-01

    Full Text Available The miR-15/107 family comprises a group of 10 paralogous microRNAs (miRNAs, sharing a 5′ AGCAGC sequence. These miRNAs have overlapping targets. In order to characterize the expression of miR-15/107 family miRNAs, we employed customized TaqMan Low-Density micro-fluid PCR-array to investigate the expression of miR-15/107 family members, and other selected miRNAs, in 11 human tissues obtained at autopsy including the cerebral cortex, frontal cortex, primary visual cortex, thalamus, heart, lung, liver, kidney, spleen, stomach and skeletal muscle. miR-103, miR-195 and miR-497 were expressed at similar levels across various tissues, whereas miR-107 is enriched in brain samples. We also examined the expression patterns of evolutionarily conserved miR-15/107 miRNAs in three distinct primary rat brain cell preparations (enriched for cortical neurons, astrocytes and microglia, respectively. In primary cultures of rat brain cells, several members of the miR-15/107 family are enriched in neurons compared to other cell types in the central nervous system (CNS. In addition to mature miRNAs, we also examined the expression of precursors (pri-miRNAs. Our data suggested a generally poor correlation between the expression of mature miRNAs and their precursors. In summary, we provide a detailed study of the tissue and cell type-specific expression profile of this highly expressed and phylogenetically conserved family of miRNA genes.

  15. Advanced flip chip packaging

    CERN Document Server

    Lai, Yi-Shao; Wong, CP

    2013-01-01

    Advanced Flip Chip Packaging presents past, present and future advances and trends in areas such as substrate technology, material development, and assembly processes. Flip chip packaging is now in widespread use in computing, communications, consumer and automotive electronics, and the demand for flip chip technology is continuing to grow in order to meet the need for products that offer better performance, are smaller, and are environmentally sustainable. This book also: Offers broad-ranging chapters with a focus on IC-package-system integration Provides viewpoints from leading industry executives and experts Details state-of-the-art achievements in process technologies and scientific research Presents a clear development history and touches on trends in the industry while also discussing up-to-date technology information Advanced Flip Chip Packaging is an ideal book for engineers, researchers, and graduate students interested in the field of flip chip packaging.

  16. CHIP, CHIP, ARRAY! THREE CHIPS FOR POST-GENOMIC RESEARCH

    Science.gov (United States)

    Cambridge Healthtech Institute recently held the 4th installment of their popular "Lab-on-a-Chip" series in Zurich, Switzerland. As usual, it was enthusiastically received and over 225 people attended the 2-1/2 day meeting to see and hear about some of the latest developments an...

  17. CHIP promotes thyroid cancer proliferation via activation of the MAPK and AKT pathways.

    Science.gov (United States)

    Zhang, Li; Liu, Lianyong; He, Xiaohua; Shen, Yunling; Liu, Xuerong; Wei, Jing; Yu, Fang; Tian, Jianqing

    2016-08-26

    The carboxyl terminus of Hsp70-interacting protein (CHIP) is a U box-type ubiquitin ligase that plays crucial roles in various biological processes, including tumor progression. To date, the functional mechanism of CHIP in thyroid cancer remains unknown. Here, we obtained evidence of upregulation of CHIP in thyroid cancer tissues and cell lines. CHIP overexpression markedly enhanced thyroid cancer cell viability and colony formation in vitro and accelerated tumor growth in vivo. Conversely, CHIP knockdown impaired cell proliferation and tumor growth. Notably, CHIP promoted cell growth through activation of MAPK and AKT pathways, subsequently decreasing p27 and increasing cyclin D1 and p-FOXO3a expression. Our findings collectively indicate that CHIP functions as an oncogene in thyroid cancer, and is therefore a potential therapeutic target for this disease.

  18. Agile and Pro-Active Public Administration as a Collaborative Networked Organization

    CERN Document Server

    Cellary, Wojciech

    2011-01-01

    In highly competitive, globalized economies and societies of always-on-line people intensively using the Internet and mobile phones, public administrations have to adapt to new challenges. Enterprises and citizens expect public administrations to be agile and pro-active to foster development. A way to achieve agility and pro-activity is application of a model of Collaborative Network Organizations in its two forms: Virtual Organizations (VO) and Virtual Organization Breeding Environments (VOBE). In the paper, advantages are shown of public administration playing a role of a Virtual Organization customer on the one hand, and a Virtual Organization member on the other hand. It is also shown how public administration playing a role of a Virtual Organization Breeding Environment may improve its agility and promote advanced technologies and management methods among local organizations. It is argued in the paper that public administration should provide a Virtual Organization Breeding Environment as a part of publi...

  19. A feasibility study for using agile contractors to promote mass housing contractors

    Directory of Open Access Journals (Sweden)

    Faraz Pouyandeh

    2015-06-01

    Full Text Available During the past few years, there have been growing changes on managing different projects using the idea of agile manufacturing by moving from the idea of plan to planning. This paper presents an empirical investigation to study whether it is possible to apply the idea of agile in mass construction projects in Iran. The study designs a questionnaire in Likert scale and distributes it among 35 well-known contractors in the field of construction projects. The questionnaire consists of 8 questions, which is considered in terms of four perspectives including culture, projects, tools and processes and employee. Using some statistical test, the study has determined that it would be possible to apply the idea of agile contractors to promote mass housing contractors.

  20. Effect of core strength training on dynamic balance and agility in adolescent badminton players.

    Science.gov (United States)

    Ozmen, Tarik; Aydogmus, Mert

    2016-07-01

    The aim of the present study was to investigate effect of core strength training (CST) on core endurance, dynamic balance and agility in adolescent badminton players. Twenty adolescent (age = 10.8 ± 0.3 years; height = 140.6 ± 4.4 cm, weight = 33.9 ± 5.8 kg) badminton players were randomly divided into two groups as training group (TG) and control (CG) group. All subjects were evaluated with Star Excursion Balance Test (SEBT), Illinois Agility Test, and the core endurance tests. The TG completed CST twice a week, for 6 weeks. There were significant increases in (p  0.05). The CST resulted in significant gains in directions of the SEBT and core endurances in adolescent badminton players, but not in agility.

  1. Agile project management – a future approach to the management of projects?

    Directory of Open Access Journals (Sweden)

    Aljaž Stare

    2013-05-01

    Full Text Available Like other professions, project management is constantly developing, new techniques are emerging, while newer, more effective approaches are being established. As an innovative modern approach, agile project management is most frequently mentioned and many experts argue that it is becoming the project management of the 21st century. The approach was developed in the field of software development and has delivered a number of novelties and benefits for the project team and the project client. On the other hand, it highlights some ‘new’ approaches that are not foreign to ‘traditional’ managers and raises a series of dilemmas about the actual benefits it brings. Even greater dilemmas arise when we attempt to use the approach for other types of projects. This speculative article summarises the most significant innovations introduced by the agile approach and critically assesses the possibility of extending the agile approach to other types of projects.

  2. Examining the Degree of Organizational Agility from Employees’ Perspective (Agriculture - Jahad Organization of Shahrekord City

    Directory of Open Access Journals (Sweden)

    Soheila Mehrabi

    2013-05-01

    Full Text Available The purpose of this study is to examine the degree of organizational agility in the Agriculture Jihad Organization in the city of Shahrekord. A sample with 150 members has been selected by stratified sampling method. The sample size has been determined through Morgan sampling table. In order to collect the research data, a self-administrated questionnaire of organizational agility has been used that has content and face validity. Also reliability of the questionnaire has been examined through Cronbachs’ Alpha coefficient. The Cronbachs’ Alpha coefficient of 0.95 confirmed reliability of the questionnaire. The results of this study indicate that the degree of organizational agility components application in the agriculture jihad organization of Shahrekord is average. Also the results of Amos Graphics show that the shared leadership and identity have the most factor loading and the robust strategy and adaptive organizational design are the second and third components.

  3. Agent-based simulation for evaluating flexible and agile business processes : Separating knowledge rules, process rules and information resources

    NARCIS (Netherlands)

    Gong, Y.; Janssen, M.

    2010-01-01

    In today’s ever changing environment organizations need flexibility and agility to be able to deal with changes. Flexibility is necessary to adapt to changes in their environment, whilst agility is needed to rapidly response to changing customer demands. In this paper a mechanism based on the separa

  4. Clients’ participation in software projects: comparative case study between an agile and a ‘traditional’ software company

    NARCIS (Netherlands)

    Racheva, Zornitza; Daneva, Maya

    2010-01-01

    One of the main characteristics of agile software development is the active and continuous participation and involvement of the clients throughout the project. According to agile proponents, this leads to building ‘the right’ product and to satisfied clients. In this paper we present a comparative s

  5. The effect of quality of electronic banking services on agility of a bank

    Directory of Open Access Journals (Sweden)

    Hooman Pourmohammad

    2016-07-01

    Full Text Available Studies have shown that in service organizations, quality can have a growth in customer satisfaction as its consequence, and when it regards the banking services, factors are brought up with regard to the quality of banking services, which include the speed in responding, providing products proportionate to the customer needs, and gaining competence. These concepts are shared by the issue of organizational agility; hence, the qualities as well as the bank's agility of the banking system embrace these concepts in common. Therefore, the study aims at studying the effect of the quality of electronic banking services on the bank's agility, and assesses the role of two mediator variables of the quality of service system and personnel behavior quality. Using a questionnaire comprised of 76 items about the above components and asking the line personnel in Bank Saderat Iran (BSI in the branches both inside and outside of Iran, the research data was collected, and stratified random sampling was used. To analyze the data, the Structural Equation Model (SEM was used and the PLS software was employed to perform the computations. Results indicated that the model of the study has a high Goodness of Fit, and the quality of the electronic banking services had a significant effect on the bank's agility. In addition, the quality of electronic banking services affects the service system quality. The system service quality, also affects the employees' behavior. Therefore, it can be said that the electronic services quality and the bank's agility affect the personnel behavior quality through the mediated effect of the service system quality. The results of the present study can help the bank's executives to promote their bank's agility and the personnel behavior quality.

  6. Acute effects of static and dynamic stretching on balance, agility, reaction time and movement time.

    Science.gov (United States)

    Chatzopoulos, Dimitris; Galazoulas, Christos; Patikas, Dimitrios; Kotzamanidis, Christos

    2014-05-01

    The purpose of this study was to compare the acute effects of three different stretching protocols on balance, agility, reaction time and movement time of the upper limbs. Participants were thirty one female high school athletes (age = 17.3 ± 0.5 yr.). All participants performed one of the following protocols on different days: (a) 3 min jogging followed by 7 min static stretching (SS), (b) 3 min jogging followed by 7 min dynamic stretching (DS), and (c) 3 min jogging followed by 7 min of rest (NS). After the protocols participants performed the following tests: dynamic balance, 505 agility test, reaction time (time between a sound stimulus and release of a button) and movement time (movement of the upper extremity over a 0.5 m distance). The order of stretching protocols and performance tests were counterbalanced to avoid carryover effects. Repeated measures analysis of variance revealed significant main effects for all variables except reaction time. The DS protocol compared to SS performed significantly better in balance, agility and movement time. Additionally, the DS protocol compared to NS performed significantly better in agility. According to the results of the study, a DS protocol is more appropriate than SS for activities that require balance, rapid change of running direction (agility) and movement time of the upper extremities. Key pointsStatic stretching has a negative effect on balance and agility performance compared to dynamic stretching.There was no effect of the stretching protocols on reaction time.Dynamic stretching was more effective than static stretching for increasing movement time of the upper extremities.

  7. Optical flows method for lightweight agile remote sensor design and instrumentation

    Science.gov (United States)

    Wang, Chong; Xing, Fei; Wang, Hongjian; You, Zheng

    2013-08-01

    Lightweight agile remote sensors have become one type of the most important payloads and were widely utilized in space reconnaissance and resource survey. These imaging sensors are designed to obtain the high spatial, temporary and spectral resolution imageries. Key techniques in instrumentation include flexible maneuvering, advanced imaging control algorithms and integrative measuring techniques, which are closely correlative or even acting as the bottle-necks for each other. Therefore, mutual restrictive problems must be solved and optimized. Optical flow is the critical model which to be fully represented in the information transferring as well as radiation energy flowing in dynamic imaging. For agile sensors, especially with wide-field-of view, imaging optical flows may distort and deviate seriously when they perform large angle attitude maneuvering imaging. The phenomena are mainly attributed to the geometrical characteristics of the three-dimensional earth surface as well as the coupled effects due to the complicated relative motion between the sensor and scene. Under this circumstance, velocity fields distribute nonlinearly, the imageries may badly be smeared or probably the geometrical structures are changed since the image velocity matching errors are not having been eliminated perfectly. In this paper, precise imaging optical flow model is established for agile remote sensors, for which optical flows evolving is factorized by two forms, which respectively due to translational movement and image shape changing. Moreover, base on that, agile remote sensors instrumentation was investigated. The main techniques which concern optical flow modeling include integrative design with lightweight star sensors along with micro inertial measurement units and corresponding data fusion, the assemblies of focal plane layout and control, imageries post processing for agile remote sensors etc. Some experiments show that the optical analyzing method is effective to

  8. Mechanical Determinants of Faster Change of Direction and Agility Performance in Female Basketball Athletes.

    Science.gov (United States)

    Spiteri, Tania; Newton, Robert U; Binetti, Molly; Hart, Nicolas H; Sheppard, Jeremy M; Nimphius, Sophia

    2015-08-01

    Change of direction (COD) and agility require the integration of multiple components to produce a faster performance. However, the mechanisms contributing to a faster performance without the confounding factor of athlete expertise or gender is currently unknown. Therefore, the purpose of this study was to assess body composition, strength, and kinetic profile required for a faster COD and agility performance across multiple directional changes. Six faster and 6 slower (n = 12) elite female basketball athletes completed a maximal dynamic back squat; eccentric and concentric only back squat; isometric midthigh pull; whole-body scan to determine lean, fat, and total mass; 505 COD test; T-test; and a multidirectional agility test over in-ground force plates to obtain relevant kinetic measures. Group (faster and slower) by test (2 × 3) multivariate analyses of variance with follow-up analyses of variance were conducted to examine differences between faster and slower groups and each COD and agility test (p ≤ 0.05). Faster athletes during the 505 COD test produced significantly greater vertical force (p = 0.002) and eccentric and isometric strength capacity (p = 0.001). Faster agility and T-test athletes demonstrated significantly shorter contact times (p = 0.001), greater propulsive impulse (p = 0.02), isometric strength, and relative lean mass compared with slower athletes. Differences between faster athletes across each test seem to be attributed to the mechanical demands of the directional change, increasing force and impulse application as the degree of directional change increased. These findings indicate that different mechanical properties are required to produce a faster COD and agility performances, and the importance of a greater strength capacity to enable greater mechanical adjustment through force production and body control, during different directional changes.

  9. IMPACT OF EXERCISE INDUCED MUSCLE DAMAGE ON SPRINT AND AGILITY PERFORMANCE

    Directory of Open Access Journals (Sweden)

    Şengül AKDENİZ

    2012-08-01

    Full Text Available Purpose: The purpose of this study was to investigate the impact of exercise induced muscle damage on sprint and agility performance.Methods: Eleven healthy male soccer players [( ±SD age: 21.63 ± 1.91 years; stature: 176.63 ± 5.31cm; body mass: 70.36 ± 3.72kg] who did not perform any high intensity physical training during last 3 months volunteered to participate in this study. Agility and sprint running times were measured, following determination of athletes muscle soreness level using visual analog scale (VAS, before (baseline and at 1st, 24th, 48th, 72nd and 96th hours after muscle damaging exercise protocol. Five sets of 20 repetitions drop jumps were performed as a muscle damage exercise protocol. Repeated measure ANOVA was used for statistical analysis.Results: Repeated measures ANOVA showed significant changes in muscle soreness [F(5-50= 196.65, p≤0.01], agility [F(5-50= 32.034, p≤0.01] and sprint running times [F(5-50= 9.28, p≤0.01] relevant with time intervals. Muscle soreness and agility test times were significantly (p≤0.05 higher than baseline values at all time intervals (1st, 24th, 48th, 72nd and 96th hours. Sprint running time was significantly (p≤0.05 increased at 1st, 24th, and 48th hours compared to baseline values.Conclusion: Consequently, results of the study revealed that exercise induced muscle damage affect agility and sprint performance negatively. The respondents should be careful in including unfamiliar exercises and exercises including intense eccentric contractions during the process of training planning for sports branches, where agility and sprint are important features.

  10. Identification and Expression Profiling of Radiation-sensitive Genes Using Plant Model System, Arabidopsis thaliana

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dong-Sub; Kang, Si-Yong; Lee, Geung-Joo; Kim, Jin-Baek

    2008-06-15

    The purpose of this study is to characterize genes specifically expressed in response to ionizing energy (gamma-rays) of acute irradiation and elucidate signalling mechanisms via functional analysis of isolated genes in Arabidopsis thaliana. Recent improvements in DNA microarray technologies and bioinformatics have made it possible to look for common features of ionizing radiation-responsive genes and their regulatory regions. It has produced massive quantities of gene expression and other functional genomics data, and its application will increase in plant genomics. In this study, we used oligonucleotide microarrays to detect the Arabidopsis genes expressed differentially by a gamma-irradiation during the vegetative (VT, 21 DAG) and reproductive (RT, 28 DAG) stages. Wild-type (Ler) Arabidopsis was irradiated with gamma-rays with 100 and 800 Gy doses. Among the 21,500 genes represented in the Agilent chip, approximately 13,500 ({sup {approx}}61.4 %) responsive genes to {nu} -irradiation were expressed with signal intensity greater than 192 when compared to the combined control (non-irradiated vegetative and reproductive pool). Expression patterns of several radiation inducible genes were confirmed by RT-PCR and Northern blotting. Our microarray results may contribute to an overall understanding of the type and quantities of genes that are expressed by an acute gamma-irradiation. In addition, to investigate the oxidative damage caused by irradiation, RT-PCR analysis for the expression of antioxidant isoenzyme genes, and a Transmission Electron Microscope (TEM) observation for visualizing the H{sub 2}O{sub 2} scavenging activity in leaves were applied.

  11. Comparative analysis of gene expression profiles of hip articular cartilage between non-traumatic necrosis and osteoarthritis.

    Science.gov (United States)

    Wang, Wenyu; Liu, Yang; Hao, Jingcan; Zheng, Shuyu; Wen, Yan; Xiao, Xiao; He, Awen; Fan, Qianrui; Zhang, Feng; Liu, Ruiyu

    2016-10-10

    Hip cartilage destruction is consistently observed in the non-traumatic osteonecrosis of femoral head (NOFH) and accelerates its bone necrosis. The molecular mechanism underlying the cartilage damage of NOFH remains elusive. In this study, we conducted a systematically comparative study of gene expression profiles between NOFH and osteoarthritis (OA). Hip articular cartilage specimens were collected from 12 NOFH patients and 12 controls with traumatic femoral neck fracture for microarray (n=4) and quantitative real-time PCR validation experiments (n=8). Gene expression profiling of articular cartilage was performed using Agilent Human 4×44K Microarray chip. The accuracy of microarray experiment was further validated by qRT-PCR. Gene expression results of OA hip cartilage were derived from previously published study. Significance Analysis of Microarrays (SAM) software was applied for identifying differently expressed genes. Gene ontology (GO) and pathway enrichment analysis were conducted by Gene Set Enrichment Analysis software and DAVID tool, respectively. Totally, 27 differently expressed genes were identified for NOFH. Comparing the gene expression profiles of NOFH cartilage and OA cartilage detected 8 common differently expressed genes, including COL5A1, OGN, ANGPTL4, CRIP1, NFIL3, METRNL, ID2 and STEAP1. GO comparative analysis identified 10 common significant GO terms, mainly implicated in apoptosis and development process. Pathway comparative analysis observed that ECM-receptor interaction pathway and focal adhesion pathway were enriched in the differently expressed genes of both NOFH and hip OA. In conclusion, we identified a set of differently expressed genes, GO and pathways for NOFH articular destruction, some of which were also involved in the hip OA. Our study results may help to reveal the pathogenetic similarities and differences of cartilage damage of NOFH and hip OA.

  12. Velocity, agility, and flexibility performance after handball training versus physical education program for preadolescent children.

    Science.gov (United States)

    Oxyzoglou, N; Kanioglou, A; Ore, G

    2009-06-01

    The performance on velocity, agility, and flexibility after six months of specific handball training or a mainstream physical education program was examined in participants (handball, n = 51; physical education, n = 70) who engaged in 3 sessions per week (60 min./sesson) including ball-handling exercises, horizontal and vertical jump shots, fast breaks, and several defensive skills. Statistically significant differences were observed between the two groups on velocity, agility, and flexibility with differences favouring the handball group. Handball training could significantly improve preadolescents' physical performance.

  13. A Novel and Compact Multi Frequency-Agile Slot Antenna for Cognitive Radio Systems

    Directory of Open Access Journals (Sweden)

    Rajeev Kumar

    2015-10-01

    Full Text Available A novel and compact frequency- agile slot antenna is presented. The antenna is switchable between 5.03-6.90GHz at twenty four different frequencies and is capable to operate multi frequency at a time. The proposed antenna has two slots etched out, one in the ground plane and another in the patch. To attain frequency agility, the effective lengths of these slots are altered by use of four p-i-n diodes which are placed within these slots at predetermined positions. Results such as return losses, gain, bandwidth and radiation patterns are presented in this paper.

  14. Effects of Ankle Braces Upon Agility Course Performance in High School Athletes

    OpenAIRE

    Beriau, Mark R.; Cox, William B.; Manning, James

    1994-01-01

    The purpose of this study was to compare the effects of wearing the AircastTM Sports Stirrup, AircastTM Training brace, Swede-OTM brace, and DonJoyTM Ankle Ligament Protector while running an agility course. Eighty-five high school athletes with no history of ankle injury and no experience in wearing any ankle support served as subjects. Each subject participated in four separate testing sessions. During sessions 1 and 4, subjects ran the agility course under the control (unbraced) conditions...

  15. Agility training in young elite soccer players: promising results compared to change of direction drills

    Science.gov (United States)

    Rouissi, M; Chtara, M; Owen, A; Bragazzi, NL; Moalla, W; Chaouachi, A; Amri, M; Chamari, K

    2016-01-01

    The aim of this study was to compare the effect of two different training programmes – change of direction (COD) vs. agility (AG) – on straight sprint (SS), COD and AG test performances in young elite soccer players. Thirty-two soccer players (age: 14.5±0.9 years; height: 171.2±5.1 cm; body mass: 56.4±7.1 kg, body fat: 10.3±2.3%) participated in a short-term (6 weeks) training study. Players were randomly assigned to two experimental groups – training with change of direction drills (COD-G, n=11) or using agility training (AG-G, n= 11) – and to a control group (CON-G, n=10). All players completed the following tests before and after training: straight sprint (15m SS), 15 m agility run with (15m-AR-B) and without a ball (15m-AR), 5-0-5 agility test, reactive agility test (RAT), and RAT test with ball (RAT-B). A significant group effect was observed for all tests (p<0.001; η2=large). In 15m SS, COD-G and AG-G improved significantly (2.21; ES=0.57 and 2.18%; ES=0.89 respectively) more than CON-G (0.59%; ES=0.14). In the 15m-AR and 5-0-5 agility test, COD-G improved significantly more (5.41%; ES=1.15 and 3.41; ES=0.55 respectively) than AG-G (3.65%; ES=1.05 and 2.24; ES=0.35 respectively) and CON-G (1.62%; ES=0.96 and 0.97; ES=0.19 respectively). Improvements in RAT and RAT-B were larger (9.37%; ES=2.28 and 7.73%; ES=2.99 respectively) in RAT-G than the other groups. In conclusion, agility performance amongst young elite soccer could be improved using COD training. Nevertheless, including a conditioning programme for agility may allow a high level of athletic performance to be achieved. PMID:28090138

  16. Hoist technology of a new agile naval gun shell-feeding system

    Institute of Scientific and Technical Information of China (English)

    LUO A-ni; LIU He-ping; SONG Hong-xia; HU Sheng-hai; ZHANG Jia-tai

    2006-01-01

    Shell-feeding velocity is an important factor affecting naval gun shooting capacity. An agile shell-feeding system was designed to ensure quick implementation of the shell-feeding task. Based on composition of the agile shell-feeding system, hoist technology was studied. Working principles were discussed and the hydraulic pressure system of the hoist was constructed. The hydraulic pressure cylinder and the accumulator were analyzed and calculated. Finally, PRO/E and ADAMS were used to simulate the hoist and its hydraulic system. It was found that this type of virtual prototype provides a good method to actualize a physical prototype.

  17. The project manager's guide to mastering agile principles and practices for an adaptive approach

    CERN Document Server

    Cobb, Charles G

    2015-01-01

    Streamline project workflow with expert agile implementation The Project Management Profession is beginning to go through rapid and profound transformation due to the widespread adoption of agile methodologies. Those changes are likely to dramatically change the role of project managers in many environments as we have known them and raise the bar for the entire project management profession; however, we are in the early stages of that transformation and there is a lot of confusion about the impact it has on project managers: There are many stereotypes and misconceptions that exist about both A

  18. DEPENDABLE PRIVACY REQUIREMENTS BY AGILE MODELED LAYERED SECURITY ARCHITECTURES – WEB SERVICES CASE STUDY

    Directory of Open Access Journals (Sweden)

    M.Upendra Kumar

    2011-07-01

    Full Text Available Software Engineering covers the definition of processes, techniques and models suitable for its environment to guarantee quality of results. An important design artifact in any software development project is the Software Architecture. Software Architecture’s important part is the set of architectural design rules. A primary goal of the architecture is to capture the architecture design decisions. An important part of these design decisions consists of architectural design rules In an MDA (Model-Driven Architecture context, the design of the system architecture is captured in the models of the system. MDA is known to be layered approach for modeling the architectural design rules and uses design patterns to improve the quality of software system. And to include the security to the software system, security patterns are introduced that offer security at the architectural level. More over, agile software development methods are used to build secure systems. There are different methods defined in agile development as extreme programming (XP, scrum, feature driven development (FDD, test driven development (TDD, etc. Agile processing is includes the phases as agile analysis, agile design and agile testing. These phases are defined in layers of MDA to provide security at the modeling level which ensures that security at the system architecture stage will improve the requirements for that system. Agile modeled Layered Security Architectures increase the dependability of the architecture in terms of privacy requirements. We validate this with a case study of dependability of privacy of Web Services Security Architectures, which helps for secure service oriented security architecture. In this paper the major part is given to model architectural design rules using MDA so that architects and developers are responsible to automatic enforcement on the detailed design and easy to understand and use by both of them. This MDA approach is implemented in use of

  19. Towards an Agile Approach in Academic Software Development - A Case Study

    Directory of Open Access Journals (Sweden)

    Logica BANICA

    2016-09-01

    Full Text Available The main focus of this paper is to emphasize the advantages of the Agile strategy when applied to a typical Project Management task. As software development has an old tradition, a comparison of the strengths of the new approach will be presented in detail, aiming to prove that the popularity of Agile is not without reason. There are software tools that help IT architects keep their teams and projects on track, and a case study for the academic environment will be discussed. The Conclusions part will summarize the results and shed some light on the future.

  20. Agility to INBONE: anterior and posterior approaches to the difficult revision total ankle replacement.

    Science.gov (United States)

    DeVries, J George; Scott, Ryan T; Berlet, Gregory C; Hyer, Christopher F; Lee, Thomas H; DeOrio, James K

    2013-01-01

    Total ankle replacement is now acknowledged as a viable alternative to ankle arthrodesis for end-stage ankle arthritis. The authors present a series of 14 patients who were converted from the Agility total ankle replacement to an INBONE total ankle replacement. This report is unique in that anterior and posterior approaches are discussed and detailed. Although the authors present successful conversion of the Agility total ankle replacement to an INBONE total ankle replacement, the difficulty of this procedure is demonstrated by the high complication rate and 2 early failures.

  1. Agile software development and its compatibility with a document-driven approach? A case study

    DEFF Research Database (Denmark)

    Heeager, Lise Tordrup; Nielsen, Peter Axel

    2009-01-01

    however have a desire to adopt agile development processes while maintaining compliance with a quality assurance standard or even a process standard. We have studied the software development process of a Danish pharmaceutical company. For market reasons the company has to comply the US Food and Drug...... a mixed development approach.......It is generally assumed among software developers and managers that a document-driven development process is incompatible with an agile development process. There are few reports on this issue and even less empirical research documenting the assumed incompatibility. More and more software companies...

  2. AGILE detection of renewed and intense gamma-ray flaring from the FSRQ CTA 102

    Science.gov (United States)

    Bulgarelli, A.; Verrecchia, F.; Tavani, M.; Vercellone, S.; Pittori, C.; Lucarelli, F.; Munar-Adrover, P.; Minervini, G.; Piano, G.; Ursi, A.; Donnarumma, I.; Fioretti, V.; Zoli, A.; Striani, E.; Cardillo, M.; Gianotti, F.; Trifoglio, M.; Giuliani, A.; Mereghetti, S.; Caraveo, P.; Perotti, F.; Chen, A.; Argan, A.; Costa, E.; Del Monte, E.; Evangelista, Y.; Feroci, M.; Lazzarotto, F.; Lapshov, I.; Pacciani, L.; Soffitta, P.; Sabatini, S.; Vittorini, V.; Pucella, G.; Rapisarda, M.; Di Cocco, G.; Fuschino, F.; Galli, M.; Labanti, C.; Marisaldi, M.; Pellizzoni, A.; Pilia, M.; Trois, A.; Barbiellini, G.; Vallazza, E.; Longo, F.; Morselli, A.; Picozza, P.; Prest, M.; Lipari, P.; Zanello, D.; Cattaneo, P. W.; Rappoldi, A.; Colafrancesco, S.; Parmiggiani, N.; Ferrari, A.; Paoletti, F.; Antonelli, A.; Giommi, P.; Salotti, L.; Valentini, G.; D'Amico, F.

    2016-12-01

    AGILE is detecting renewed and intense gamma-ray emission above 100 MeV from the flat-spectrum radio quasar CTA 102 (also known as 4C +11.69, PKS 2230+11, 5BZQ J2232+1143 and as the gamma-ray source as 3EG J2232+1147, 3FGL J2232.5+114), recently reported in flaring activity by AGILE on December 14 (ATel #9863), December 9 (Atel #9840), November 24 and 11, 2016 (ATel #9788, #9743), by Fermi-LAT on December 16 (ATel #9869), in optical/NIR/radio (ATel #9884, #9868, #9821, #9808 and #9801).

  3. AGILE detection of intense gamma-ray emission from the FSRQ CTA102

    Science.gov (United States)

    Bulgarelli, A.; Tavani, M.; Verrecchia, F.; Pittori, C.; Lucarelli, F.; Munar-Adrover, P.; Minervini, G.; Piano, G.; Ursi, A.; Donnarumma, I.; Fioretti, V.; Zoli, A.; Vercellone, S.; Striani, E.; Cardillo, M.; Gianotti, F.; Trifoglio, M.; Giuliani, A.; Mereghetti, S.; Caraveo, P.; Perotti, F.; Chen, A.; Argan, A.; Costa, E.; Del Monte, E.; Evangelista, Y.; Feroci, M.; Lazzarotto, F.; Lapshov, I.; Pacciani, L.; Soffitta, P.; Sabatini, S.; Vittorini, V.; Pucella, G.; Rapisarda, M.; Di Cocco, G.; Fuschino, F.; Galli, M.; Labanti, C.; Marisaldi, M.; Pellizzoni, A.; Pilia, M.; Trois, A.; Barbiellini, G.; Vallazza, E.; Longo, F.; Morselli, A.; Picozza, P.; Prest, M.; Lipari, P.; Zanello, D.; Cattaneo, P. W.; Rappoldi, A.; Colafrancesco, S.; Parmiggiani, N.; Ferrari, A.; Paoletti, F.; Antonelli, A.; Giommi, P.; Salotti, L.; Valentini, G.; D'Amico, F.

    2016-12-01

    AGILE is detecting enhanced gamma-ray emission above 100 MeV from a position consistent with the flat spectrum radio quasar CTA 102 (also known as 4C +11.69, PKS 2230+11, 5BZQ J2232+1143 and as gamma-ray source as 3EG J2232+1147, 3FGL J2232.5+114), recently reported in flaring activity by AGILE on December 9 (Atel #9841), November 24 and 11, 2016 (ATel #9788, #9743), and in optical/NIR extraordinary outburst (ATel #9821, #9808 and #9801).

  4. Agile software development and the barriers to transfer of knowledge: An interpretive case study

    DEFF Research Database (Denmark)

    Heeager, Lise Tordrup; Nielsen, Peter Axel

    2013-01-01

    practices in an interpretive case study. The case company is a pharmaceutical firm where we studied how they develop software and how they transfer their own experience. Based on the literature we develop an initial framework of barriers to knowledge transfer and apply it to interpret the case study. From...... this case study we are able to discuss the initial framework and extend it to a framework of knowledge transfer of agile practices. The framework provides a better understanding of the barriers to knowledge transfer of agile practices. The paper contributes with (1) an application of the framework...

  5. AGILE detection of gamma-ray activity from the FSRQ S5 1039+81 region

    Science.gov (United States)

    Bulgarelli, A.; Lucarelli, F.; Verrecchia, F.; Pittori, C.; Piano, G.; Munar-Adrover, P.; Fioretti, V.; Zoli, A.; Tavani, M.; Vercellone, S.; Donnarumma, I.; Striani, E.; Cardillo, M.; Gianotti, F.; Trifoglio, M.; Giuliani, A.; Mereghetti, S.; Caraveo, P.; Perotti, F.; Chen, A.; Argan, A.; Costa, E.; Del Monte, E.; Evangelista, Y.; Feroci, M.; Lazzarotto, F.; Lapshov, I.; Pacciani, L.; Soffitta, P.; Sabatini, S.; Vittorini, V.; Pucella, G.; Rapisarda, M.; Di Cocco, G.; Fuschino, F.; Galli, M.; Labanti, C.; Marisaldi, M.; Pellizzoni, A.; Pilia, M.; Trois, A.; Barbiellini, G.; Vallazza, E.; Longo, F.; Morselli, A.; Picozza, P.; Prest, M.; Lipari, P.; Zanello, D.; Cattaneo, P. W.; Rappoldi, A.; Colafrancesco, S.; Parmiggiani, N.; Ferrari, A.; Antonelli, A.; Giommi, P.; Salotti, L.; Valentini, G.; D'Amico, F.

    2016-04-01

    The AGILE satellite is detecting a bright gamma-ray source consistent with the position of the FSRQ S5 1039+81 (also known as 5BZQJ1044+8054). Integrating from 2016-04-05 19:13 UT to 2016-04-07 19:13 UT, a maximum likelihood analysis of AGILE data yields the detection of a source with a flux of (1.5 +/- 0.45) x 10^-6 ph/cm2/s (E > 100 MeV) at a significance level of 5.3 sigma.

  6. Current State of Agile Methodologies Worldwide and in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Martin Tománek

    2015-06-01

    Full Text Available The objective of this research paper is to compare the current state of agile methodologies in the world and in the Czech Republic. The comparison is executed as the comparative analysis of two publicly available researches conducted in 2013 and published in 2014. The comparison is further enriched by the results of the unpublished survey in the global logistics company which was conducted also in 2013. The potential trend for agile methodologies in the Czech Republic is also discussed with regard to the worldwide trend.

  7. Analysis on critical success factors for agile manufacturing evaluation in original equipment manufacturing industry-an AHP approach

    Science.gov (United States)

    Ajay Guru Dev, C.; Senthil Kumar, V. S.

    2016-09-01

    Manufacturing industries are facing challenges in the implementation of agile manufacturing in their products and processes. Agility is widely accepted as a new competitive concept in the manufacturing sector in fulfilling varying customer demand. Thus, evaluation of agile manufacturing in industries has become a necessity. The success of an organisation depends on its ability to manage finding the critical success factors and give them special and continued attention in order to bring about high performance. This paper proposes a set of critical success factors (CSFs) for evaluating agile manufacturing considered appropriate for the manufacturing sector. The analytical hierarchy process (AHP) method is applied for prioritizing the success factors, by summarizing the opinions of experts. It is believed that the proposed CSFs enable and assist manufacturing industries to achieve a higher performance in agile manufacturing so as to increase competitiveness.

  8. Analysis on critical success factors for agile manufacturing evaluation in original equipment manufacturing industry-an AHP approach

    Science.gov (United States)

    Ajay Guru Dev, C.; Senthil Kumar, V. S.

    2016-08-01

    Manufacturing industries are facing challenges in the implementation of agile manufacturing in their products and processes. Agility is widely accepted as a new competitive concept in the manufacturing sector in fulfilling varying customer demand. Thus, evaluation of agile manufacturing in industries has become a necessity. The success of an organisation depends on its ability to manage finding the critical success factors and give them special and continued attention in order to bring about high performance. This paper proposes a set of critical success factors (CSFs) for evaluating agile manufacturing considered appropriate for the manufacturing sector. The analytical hierarchy process (AHP) method is applied for prioritizing the success factors, by summarizing the opinions of experts. It is believed that the proposed CSFs enable and assist manufacturing industries to achieve a higher performance in agile manufacturing so as to increase competitiveness.

  9. Effect of short burst activities on sprint and agility performance in 11- to 12-year-old boys.

    Science.gov (United States)

    Pettersen, Svein A; Mathisen, Gunnar E

    2012-04-01

    There are limited data on how coordinative sprint drills and maximal short burst activities affects children's sprint and agility performance. The purpose of the present study was to investigate the effect of short burst activities on sprint and agility performance in 11- to 12-year-old boys. A training group (TG) of 14 boys followed a 6-week, 1-hour·week(-1), training program consisting of different short burst competitive sprinting activities. Eleven boys of similar age served as controls (control group [CG]). Pre- and posttests assessed 10-m sprint, 20-m sprint, and agility performance. Results revealed significant performance improvement in all tests within TG (p sprint test. Furthermore, the relationships between the performances in straight-line sprint and agility showed a significant transfer effect (r = 0.68-0.75, p sprint and agility performance in 11- to 12-year-old boys.

  10. The conceptual framework for Agility evaluating and organizations ranking using Interval Fuzzy Electere technique (Case study: Iran Alloy Steel Industry

    Directory of Open Access Journals (Sweden)

    * Hossein Aghabagheri

    2013-01-01

    Full Text Available The purpose of this article is to propose a technique for agility evaluation and ranking production units using verbal variables set and if-then rules. First, organization’s agility level has been evaluated by Fuzzy Agility Index (FAI, and then, production units of the organization have been ranked by Interval Fuzzy ELECTRE technique. By the use of this technique, all of the alternatives have been evaluated based on non-rating comparisons and those of ineffective have been removed. In the next stage, a four dimensional matrix has been proposed as a facilitating tool for decision making process and achievement of managers' goals. In fact, appropriate strategies have been determined for planning and decision making, according to available conditions and ideal situations.     Keywords: Agile Manufacturing System (AMS, Fuzzy logic, Fuzzy Agility Index (FAI, MCDM methods, Interval Fuzzy ELECTRE technique.

  11. Data transfer through beam steering using agile lensing

    Science.gov (United States)

    Arshad, Muhammad Assad; Reza, Syed Azer; Muhammad, Ahsan

    2016-04-01

    This paper presents a data transfer scheme using multi-focus tunable lenses. The design involves the use of a standard laser source and a variable focus agile lens to steer to the laser beam that passes through the lens. In our proposed system, the beam steer angle depends on an input electrical signal which drives the tunable lens. Therefore the beam steer angle is made to follow the variations in the input electrical drive signal. This is extremely interesting for data transfer applications as the data signal can be used as the input drive signal to the lens. The laser beam is steered according to the input data voltage levels and when the beam is incident on a photo-detector of a finite size, only a fraction of its total incident optical power is received by the photo-detector. This power contribution is proportional to the fraction of the total number of photons per unit area which are incident on the active area of the detector. The remaining photons which are not incident on the photo-detector do not contribute to the received power at the photo-detector. We present the theory of beam steering through a tunable lens and present a theoretical framework which governs data transfer through the proposed method. We also present the transfer function of the proposed system which helps us to calculate its essential theoretical performance parameters such as modulation depth and bit error rates. We also present experimental results to demonstrate efficient data transfer through the proposed method. As tunable lenses are primarily deployed in motion-free multi-focus cameras hence most of the modern portable devices such as cellphones and tablets use these lenses to operate the in-built variable focus cameras that are part of these devices. Because tunable lenses are commonly present in several different portable devices, the proposed method of data transfer between two devices is highly promising as it expands the use of the already deployed tunable lenses with

  12. Between Oais and Agile a Dynamic Data Management Approach

    Science.gov (United States)

    Bennett, V. L.; Conway, E. A.; Waterfall, A. M.; Pepler, S.

    2015-12-01

    In this paper we decribe an approach to the integration of existing archival activities which lies between compliance with the more rigid OAIS/TRAC standards and a more flexible "Agile" approach to the curation and preservation of Earth Observation data. We provide a high level overview of existing practice and discuss how these procedures can be extended and supported through the description of preservation state. The aim of which is to facilitate the dynamic controlled management of scientific data through its lifecycle. While processes are considered they are not statically defined but rather driven by human interactions in the form of risk management/review procedure that produce actionable plans, which are responsive to change. We then proceed by describing the feasibility testing of extended risk management and planning procedures which integrate current practices. This was done through the CEDA Archival Format Audit which inspected British Atmospheric Data Centre and NERC Earth Observation Data Centre Archival holdings. These holdings are extensive, comprising of around 2 Petabytes of data and 137 million individual files, which were analysed and characterised in terms of format, based risk. We are then able to present an overview of the format based risk burden faced by a large scale archive attempting to maintain the usability of heterogeneous environmental data sets We continue by presenting a dynamic data management information model and provide discussion of the following core model entities and their relationships: Aspirational entities, which include Data Entity definitions and their associated Preservation Objectives. Risk entities, which act as drivers for change within the data lifecycle. These include Acquisitional Risks, Technical Risks, Strategic Risks and External Risks Plan entities, which detail the actions to bring about change within an archive. These include Acquisition Plans, Preservation Plans and Monitoring plans which support

  13. Lab on a chip genotyping for Brucella spp. based on 15-loci multi locus VNTR analysis

    Directory of Open Access Journals (Sweden)

    Marianelli Cinzia

    2009-04-01

    Full Text Available Abstract Background Brucellosis is an important zoonosis caused by the genus Brucella. In addition Brucella represents potential biological warfare agents due to the high contagious rates for humans and animals. Therefore, the strain typing epidemiological tool may be crucial for tracing back source of infection in outbreaks and discriminating naturally occurring outbreaks versus bioterroristic event. A Multiple Locus Variable-number tandem repeats (VNTR Analysis (MLVA assay based on 15 polymorphic markers was previously described. The obtained MLVA band profiles may be resolved by techniques ranging from low cost manual agarose gels to the more expensive capillary electrophoresis sequencing. In this paper a rapid, accurate and reproducible system, based on the Lab on a chip technology was set up for Brucella spp. genotyping. Results Seventeen DNA samples of Brucella strains isolated in Sicily, previously genotyped, and twelve DNA samples, provided by MLVA Brucella VNTR ring trial, were analyzed by MLVA-15 on Agilent 2100. The DNA fragment sizes produced by Agilent, compared with those expected, showed discrepancies; therefore, in order to assign the correct alleles to the Agilent DNA fragment sizes, a conversion table was produced. In order to validate the system twelve unknown DNA samples were analyzed by this method obtaining a full concordance with the VNTR ring trial results. Conclusion In this paper we described a rapid and specific detection method for the characterization of Brucella isolates. The comparison of the MLVA typing data produced by Agilent system with the data obtained by standard sequencing or ethidium bromide slab gel electrophoresis showed a general concordance of the results. Therefore this platform represents a fair compromise among costs, speed and specificity compared to any conventional molecular typing technique.

  14. GeneChip expression profiling reveals the alterations of energy metabolism related genes in osteocytes under large gradient high magnetic fields.

    Directory of Open Access Journals (Sweden)

    Yang Wang

    Full Text Available The diamagnetic levitation as a novel ground-based model for simulating a reduced gravity environment has recently been applied in life science research. In this study a specially designed superconducting magnet with a large gradient high magnetic field (LG-HMF, which can provide three apparent gravity levels (μ-g, 1-g, and 2-g, was used to simulate a space-like gravity environment. Osteocyte, as the most important mechanosensor in bone, takes a pivotal position in mediating the mechano-induced bone remodeling. In this study, the effects of LG-HMF on gene expression profiling of osteocyte-like cell line MLO-Y4 were investigated by Affymetrix DNA microarray. LG-HMF affected osteocyte gene expression profiling. Differentially expressed genes (DEGs and data mining were further analyzed by using bioinfomatic tools, such as DAVID, iReport. 12 energy metabolism related genes (PFKL, AK4, ALDOC, COX7A1, STC1, ADM, CA9, CA12, P4HA1, APLN, GPR35 and GPR84 were further confirmed by real-time PCR. An integrated gene interaction network of 12 DEGs was constructed. Bio-data mining showed that genes involved in glucose metabolic process and apoptosis changed notablly. Our results demostrated that LG-HMF affected the expression of energy metabolism related genes in osteocyte. The identification of sensitive genes to special environments may provide some potential targets for preventing and treating bone loss or osteoporosis.

  15. GeneChip analysis of hippocampal gene expression profiles of short- and long-attack-latency mice : Technical and biological implications

    NARCIS (Netherlands)

    Feldker, DEM; Datson, NA; Veenema, AH; Proutski, [No Value; Lathouwers, D; de Kloet, ER; Vreugdenhil, E

    2003-01-01

    To gain insight into the molecular mechanisms underlying the behavioral differences between two mouse lines genetically selected for long and short attack latency (LAL and SAL mice, respectively), we have recently applied the large-scale gene expression profiling method known as serial analysis of g

  16. Disciplined Agility as a Strategic Enabler Capability for Facilitating Internal Organizational Changes Using the Synergy between SEI-TSP/PSP and Agile Methodologies

    Directory of Open Access Journals (Sweden)

    Ahmed S. Elsheikh

    2016-01-01

    Full Text Available The synergy between the disciplined (i.e. plan-driven and agile (i.e. adaptive approaches can achieve results that exceed any one of them separately in software development. In this paper, we focus on how introducing the disciplined agility approach called ?SEI-Team Software Process? in MiniMax Software helped the company deals with the transitions between different stages in the internal learning and development change. Major stages, their discovered challenges, the needed methodological shifts and achieved breakthrough improvements in each stage will be explained. This development cycle can be summarized into three major stages. Summary of achievements per stage will be presented as well as a cross-stages analysis to illustrate the impact of these transitions and changes.

  17. IOT Test System——Anite SAS Based on Agilent 8960%基于Agilent 8960的IOT测试系统——Anite SAS

    Institute of Scientific and Technical Information of China (English)

    宋崇汶; 孙向前; 买望

    2009-01-01

    文章对基于Agilent 8960的IOT测试系统--SAS进行了全面的介绍.首先介绍了互操作性测试即IOT测试的必要性和基本内容,接着详细阐述了如何应用SAS系统实现IOT测试,最后对SAS系统的优点进行了分析.

  18. DoD Information Assurance and Agile: Challenges and Recommendations Gathered Through Interviews with Agile Program Managers and DoD Accreditation Reviewers

    Science.gov (United States)

    2012-11-01

    research report. Although data was collected in a fairly methodical way, no formal research methodology was applied to data collection and analysis...testing and certification are found in industry, too (e.g., water- Scrum -fall). The Office of the Secretary of Defense and other organizations have...report titled Water- Scrum -Fall Is The Reality Of Agile For Most Organizations Today. This paper served as the inspiration for many related blog

  19. China's first WLAN chips

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ The wireless local area network (WLAN) chips independently developed by CAS researchers were in the limelight of the recent Electronic Manufacture Exposition held in Suzhou, east China's Jiangsu Province.

  20. CHIP Enrollment Reports

    Data.gov (United States)

    U.S. Department of Health & Human Services — CHIP quarterly and annual statistical enrollment reports. The quarterly reports contain point-in-time and ever enrolled data and the annual reports contain ever...

  1. Medicaid CHIP ESPC Database

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Environmental Scanning and Program Characteristic (ESPC) Database is in a Microsoft (MS) Access format and contains Medicaid and CHIP data, for the 50 states and...

  2. Experiment list: SRX877859 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 1459: WHIM12 ZNF165 IP; Homo sapiens; ChIP-Seq source_name=breast cancer tumor derived cell line stably expressing... ZNF165-V5 || tumor type=TNBC || cell line=WHIM12 stably expressing ZNF165-V5 || chip antibody=Polyclo

  3. Experiment list: SRX877858 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available SM1611458: WHIM12 ZNF165 Input; Homo sapiens; ChIP-Seq source_name=breast cancer tumor derived cell line stably expressing... ZNF165-V5 || tumor type=TNBC || cell line=WHIM12 stably expressing ZNF165-V5 || chip antibody

  4. Engineering Flexible and Agile Services: A Reference Architecture for Administrative Processes

    NARCIS (Netherlands)

    Gong, Y.

    2012-01-01

    To provide up-to-date services towards citizens and businesses, administrative organizations need to make sure their business services and processes and supporting applications are flexible and agile enough to deal with changing situations and ensure legal compliance all the time. The research prese

  5. Lean vs Agile in the Context of Complexity Management in Organizations

    Science.gov (United States)

    Putnik, Goran D.; Putnik, Zlata

    2012-01-01

    Purpose: The objective of this paper is to provide a deeper insight into the relationship of the issue "lean vs agile" in order to inform managers towards more coherent decisions especially in a dynamic, unpredictable, uncertain, non-linear environment. Design/methodology/approach: The methodology is an exploratory study based on secondary data…

  6. An experimental evaluation of the Agility MLC for motion-compensated VMAT delivery

    Science.gov (United States)

    Davies, G. A.; Clowes, P.; Bedford, J. L.; Evans, P. M.; Webb, S.; Poludniowski, G.

    2013-07-01

    An algorithm for dynamic multileaf-collimator (dMLC) tracking of a target performing a known a priori, rigid-body motion during volumetric modulated arc therapy (VMAT), has been experimentally validated and applied to investigate the potential of the Agility (Elekta AB, Stockholm, Sweden) multileaf-collimator (MLC) for use in motion-compensated VMAT delivery. For five VMAT patients, dosimetric measurements were performed using the Delta4 radiation detector (ScandiDos, Uppsala, Sweden) and the accuracy of dMLC tracking was evaluated using a gamma-analysis, with threshold levels of 3% for dose and 3 mm for distance-to-agreement. For a motion trajectory with components in two orthogonal directions, the mean gamma-analysis pass rate without tracking was found to be 58.0%, 59.0% and 60.9% and was increased to 89.1%, 88.3% and 93.1% with MLC tracking, for time periods of motion of 4 s, 6 s and 10 s respectively. Simulations were performed to compare the efficiency of the Agility MLC with the MLCi MLC when used for motion-compensated VMAT delivery for the same treatment plans and motion trajectories. Delivery time increases from a static-tumour to dMLC-tracking VMAT delivery were observed in the range 0%-20% for the Agility, and 0%-57% with the MLCi, indicating that the increased leaf speed of the Agility MLC is beneficial for MLC tracking during lung radiotherapy.

  7. Supply chain network design problem for a new market opportunity in an agile manufacturing system

    Science.gov (United States)

    Babazadeh, Reza; Razmi, Jafar; Ghodsi, Reza

    2012-08-01

    The characteristics of today's competitive environment, such as the speed with which products are designed, manufactured, and distributed, and the need for higher responsiveness and lower operational cost, are forcing companies to search for innovative ways to do business. The concept of agile manufacturing has been proposed in response to these challenges for companies. This paper copes with the strategic and tactical level decisions in agile supply chain network design. An efficient mixed-integer linear programming model that is able to consider the key characteristics of agile supply chain such as direct shipments, outsourcing, different transportation modes, discount, alliance (process and information integration) between opened facilities, and maximum waiting time of customers for deliveries is developed. In addition, in the proposed model, the capacity of facilities is determined as decision variables, which are often assumed to be fixed. Computational results illustrate that the proposed model can be applied as a power tool in agile supply chain network design as well as in the integration of strategic decisions with tactical decisions.

  8. On the importance of agile communication skills in BPM education: Design principles for international seminars

    Directory of Open Access Journals (Sweden)

    Jan vom Brocke

    2012-12-01

    Full Text Available Business Process Management (BPM has evolved as an integrated management discipline that aims to enable organizations to continuously innovate and improve their operations. BPM experts are exposed to communication processes involving people from various backgrounds (e.g., various business areas, fields of expertise, and cultures. Research in applied linguistics has shown that it is difficult to plan for constellations of such communication processes; thus, agile communication skills are vital for successful business communication. Teaching programs for BPM, however, do not account for these skills. Rather, they mainly address methods for the analysis, implementation, and management of business processes. As a result, graduates—though they may be technically and methodologically apt—face unexpected challenges due to communication deficiencies in BPM projects. BPM research has shown that deficiencies in communication are in fact among the most frequent reasons for project failure. In this paper, we present a course setting to teach agile communication skills in BPM education. The approach is informed by literature on BPM education as well as theories from virtual collaboration education. We have evaluated it in an international virtual seminar involving seven European universities. We argue for the importance of agile communication skills in BPM education. In addition, we present design principles for courses to teach agile communication skills that can be applied by fellow academics.

  9. Reference values for anaerobic performance and agility in ambulatory children and adolescents with cerebral palsy

    NARCIS (Netherlands)

    Verschuren, Olaf; Bloemen, Manon; Kruitwagen, Cas; Takken, Tim

    2010-01-01

    Aim The aim of this study was to provide reference values of anaerobic performance and agility in a group of children and adolescents with spastic cerebral palsy (CP). Method A total of 300 children (184 males, 116 females) with spastic CP were recruited from 26 rehabilitation centres in six differe

  10. Helicopter downwash measured by continuous-wave Doppler lidars with agile beam steering

    DEFF Research Database (Denmark)

    Sjöholm, Mikael; Angelou, Nikolas; Hansen, Per;

    2012-01-01

    A ground-based remote sensing short-range WindScanner with agile beam steering based on a modified ZephIR continuous-wave wind lidar (LIght Detection And Ranging) and a double prism arrangement has recently been developed at the Department of Wind Energy at the DTU Risø campus. The Wind...

  11. Solution of agile codification rules and regulations management in municipality by using ISO 2009 and PMBOK

    Directory of Open Access Journals (Sweden)

    Esmail Radgohar

    2016-06-01

    Full Text Available Growing demand for construction cases regulation systems in municipalities and engineering organization faces with many problems and it is necessaryto use agile framework for legislating municipal, construction and reconstruction laws. Up to now no one has been searched in legislating municipal and construction lows by using agility framework and documentation.In this paper, cases and problems due to lack of proper documentation in accordance with ISO9001 standards and the use of these standards PMBOK and agile with a legislative system, Municipalities and engineering organization that is directly linked with the diverse demands of the people, define and document the patterns have been studied and documented an agile framework for legislation of lows. The administrative process will not be interrupted or dispute cases because of lack of appropriate regulations or standards developed document will be discussed and the delay in the implementation of projects out of these challenges are proposed by chart patterns.The implementation of those flowcharts case: 1. To prevent parallel tasks. 2. The possibility of working in different sectors to minimize interference. 3. In case of default, negligence or problems in the process of work, the unit and the delay interval arguably be identified and action to solve problems and be purposeful delay compensation. 4. Documents allow a clear and transparent and there is no confusion for the applicant and the exporter. 5. Principal management can manage duties unitedly without parallel work and confining pressure and interfere with each section.

  12. Promising Practices in Professional Growth & Support: "Case Study of Agile Mind"

    Science.gov (United States)

    Education Resource Strategies, 2013

    2013-01-01

    Four organizations with promising practices in teacher Professional Growth & Support have significantly raised outcomes for low-income students. The charter management networks, Achievement First and Aspire Public Schools, and the two reform organizations, Teach Plus and Agile Mind, have successfully increased student achievement with a…

  13. An Agile Methodology for Implementing Service-Oriented Architecture in Small and Medium Sized Organizations

    Science.gov (United States)

    Laidlaw, Gregory

    2013-01-01

    The purpose of this study is to evaluate the use of Lean/Agile principles, using action research to develop and deploy new technology for Small and Medium sized enterprises. The research case was conducted at the Lapeer County Sheriff's Department and involves the initial deployment of a Service Oriented Architecture to alleviate the data…

  14. An agile planning and control framework for customer-order driven discrete parts manufacturing environments

    NARCIS (Netherlands)

    Assen, van M.F.; Hans, E.W.; Velde, van de S.L.

    2000-01-01

    In this paper, we present a planning and control framework for manufacture-to-order environments that enables and supports agile-based discrete parts manufacturing. The characteristic elements of our framework are that it is decentralized, logistics and business oriented, and that it recognizes that

  15. Agile-Lean Software Engineering (ALSE) Evaluating Kanban in Systems Engineering

    Science.gov (United States)

    2013-03-06

    WHS TO 020, RT 035a Report No. SERC-2013-TR-022-2 March 6, 2013 73 12. V. Basili and D. Weiss, "A Methodology for Collecting Valid Software...changes in the way work is accomplished or imply specific organizational structures like other agile methods (e.g. Scrum ). Such systems can be set up

  16. CONSUMER BEHAVIOR AND ENTERPRISE AGILITY – A MODEL OF THE SURVEYED INDICATORS

    Directory of Open Access Journals (Sweden)

    BOIER Rodica

    2009-05-01

    Full Text Available Enhancing the agility of the response to market demands is one of the most desirable qualities for the management of today’s enterprise, which is facing an unstable environment, with abrupt, frequent and unpredictable changes. The paper proposes a model o

  17. A Quantitative Examination of Critical Success Factors Comparing Agile and Waterfall Project Management Methodologies

    Science.gov (United States)

    Pedersen, Mitra

    2013-01-01

    This study investigated the rate of success for IT projects using agile and standard project management methodologies. Any successful project requires use of project methodology. Specifically, large projects require formal project management methodologies or models, which establish a blueprint of processes and project planning activities. This…

  18. A user-oriented resource scheduling method for improving agile software pattern in cloud environment

    Institute of Scientific and Technical Information of China (English)

    龙飞; 杨昌; 荣辉桂; 李建方

    2016-01-01

    The crowdsourcing, as a service pattern in cloud environment, usually aims at the cross-disciplinary cooperation and creating value together with customers and becomes increasingly prevalent. Software process, as a kind of software development and management strategy, is defined as a series of activities implemented by software life cycle and provides a set of rules for various phases of the software engineering to achieve the desired objectives. With the current software development cycle getting shorter, facing more frequent needs change and fierce competition, a new resource management pattern is proposed to respond to these issues agilely by introducing the crowdsourcing service to agile software development for pushing the agility of software process. Then, a user-oriented resource scheduling method is proposed for rational use of various resources in the process and maximizing the benefits of all parties. From the experimental results, the proposed pattern and resources scheduling method reduces greatly the resource of project resource manager and increases the team resource utilization rate, which greatly improves the agility of software process and delivers software products quickly in crowdsourcing pattern.

  19. Offering of New Approach for Agility of Organization Based on Model Driven

    Directory of Open Access Journals (Sweden)

    Beenazir ganji

    2015-01-01

    Full Text Available High speed in changing of different technologies ,change in demand of customers in organizations, and high competition of companies and institution make organizations to use different methods for rapid adaption with environmental changes in order to gain a larger share of the business market. It is inevitable to create organizations with high speed and flexibility in response to variable, unstable, and unpredictable environment. All of these purposes are achieved by “organizational agility.” Time and cost are two effective parameters in selecting approaches for adaption of environmental changes in agile organizations. What are the quickest and the most cost-effective way for adapting systems with new technologies? The importance of agility was presented in this paper. a new approach is proposed to reach an agile organization with minimum time and cost. The mentioned approach is flexible against changes and it can coordinate with these changes rapidly. Capabilities of this architecture showed that it included the essential maturity for rapidadaption of organizations with new technologies and also, it had an appropriate place in this field.

  20. Cross Sectional Study of Agile Software Development Methods and Project Performance

    Science.gov (United States)

    Lambert, Tracy

    2011-01-01

    Agile software development methods, characterized by delivering customer value via incremental and iterative time-boxed development processes, have moved into the mainstream of the Information Technology (IT) industry. However, despite a growing body of research which suggests that a predictive manufacturing approach, with big up-front…