WorldWideScience

Sample records for aged 80 and over

  1. Relationship between resting heart rate and anthropometric, metabolic and hemodynamic parameters in the elderly aged 80 years and over

    OpenAIRE

    Fabrício E. Rossi; Ana Laura Ricci-Vitor; Igor C. Gomes; Vanessa R. Santos; Sabino, João Paulo J.; Luiz Guilherme S. Branco; Diego G. D. Christofaro; Vanderlei, Luiz Carlos M.; Ismael F. Freitas Junior

    2016-01-01

    Abstract This study examined the relationship between resting heart rate (RHRr) and anthropometric, metabolic and hemodynamic parameters in subjects aged 80 years and over. One hundred thirteen individuals were divided into two groups (RHR:

  2. Objective measures of physical activity, white matter integrity and cognitive status in adults over age 80.

    Science.gov (United States)

    Tian, Qu; Glynn, Nancy W; Erickson, Kirk I; Aizenstein, Howard J; Simonsick, Eleanor M; Yaffe, Kristine; Harris, Tamara B; Kritchevsky, Stephen B; Boudreau, Robert M; Newman, Anne B; Lopez, Oscar L; Saxton, Judith; Rosano, Caterina

    2015-05-01

    The neuroprotective effects of physical activity (PA) are consistently shown in older adults, but the neural substrates, particularly in white matter (WM), are understudied, especially in very old adults with the fastest growth rate and the highest risk of dementia. This study quantified the association between PA and WM integrity in adults over 80. The moderating effects of cardiometabolic conditions, physical functional limitations and WM hyperintensities were also examined, as they can affect PA and brain integrity. Fractional anisotropy (FA) from normal-appearing WM via diffusion tensor imaging and WM hyperintensities were obtained in 90 participants (mean age = 87.4, 51.1% female, 55.6% white) with concurrent objective measures of steps, active energy expenditure (AEE in kcal), duration (min), and intensity (metabolic equivalents, METs) via SenseWear Armband. Clinical adjudication of cognitive status, prevalence of stroke and diabetes, systolic blood pressure, and gait speed were assessed at time of neuroimaging. Participants were on average sedentary (mean ± SD/day: 1766 ± 1345 steps, 202 ± 311 kcal, 211 ± 39 min, 1.8 ± 1.1 METs). Higher steps, AEE and duration, but not intensity, were significantly associated with higher FA. Associations were localized in frontal and temporal areas. Moderating effects of cardiometabolic conditions, physical functional limitations, and WM hyperintensities were not significant. Neither FA nor PA was related to cognitive status. Older adults with a sedentary lifestyle and a wide range of cardiometabolic conditions and physical functional limitations, displayed higher WM integrity in relation to higher PA. Studies of very old adults to quantify the role of PA in reducing dementia burden via WM integrity are warranted. PMID:25655514

  3. Relationship between resting heart rate and anthropometric, metabolic and hemodynamic parameters in the elderly aged 80 years and over

    Directory of Open Access Journals (Sweden)

    Fabrício E. Rossi

    2016-03-01

    Full Text Available Abstract This study examined the relationship between resting heart rate (RHRr and anthropometric, metabolic and hemodynamic parameters in subjects aged 80 years and over. One hundred thirteen individuals were divided into two groups (RHR:<66 beats/min and ≥66 beats/min. Anthropometric parameters (weight, height, body mass index and waist circumference (WC were measured. Hemodynamic parameters (systolic (SBP and diastolic (DBP pressure were measured and pulse pressures (PP were obtained. Metabolic parameters were fasting blood glucose, triglycerides and total cholesterol. In elderly aged 80 and over, RHR influenced the changes observed in DBP, PP and triglycerides. Additionally, subjects with RHR≥66 beats/min had higher DBP, glucose, total cholesterol and lower PP as compared with elderly with RHR<66 beats/min. Men demonstrated greater weight, height, and WC than women while women had higher percentage of body fat, trunk fat, and higher total cholesterol. Thus, subjects with 80 years old and over who present RHR≥66 have higher DBP and lower PP and heart rate variability compared with the elderly with RHR<66.

  4. Pharmacokinetics of Vancomycin in Elderly Patients Aged over 80 Years.

    Science.gov (United States)

    Bourguignon, Laurent; Cazaubon, Yoann; Debeurme, Guillaume; Loue, Constance; Ducher, Michel; Goutelle, Sylvain

    2016-08-01

    Since the 1950s, vancomycin has remained a reference treatment for severe infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus Vancomycin is a nephrotoxic and ototoxic drug mainly eliminated through the kidneys. It has a large interindividual pharmacokinetic variability, which justifies monitoring its plasma concentrations in patients. This is especially important in patients aged over 80 years, who frequently have renal impairment. However, the pharmacokinetics of vancomycin in this population is very poorly described in the literature. The objective of this work was to propose a model able to predict the pharmacokinetics of vancomycin in very elderly people. First, a population pharmacokinetic model was carried out using the algorithm NPAG (nonparametric adaptive grid) on a database of 70 hospitalized patients aged over 80 years and treated with vancomycin. An external validation then was performed on 41 patients, and the predictive capabilities of the model were assessed. The model had two compartments and six parameters. Body weight and creatinine clearance significantly influenced vancomycin volume of distribution and body clearance, respectively. The means (± standard deviations) of vancomycin volume of distribution and clearance were 36.3 ± 15.2 liter and 2.0 ± 0.9 liter/h, respectively. In the validation group, the bias and precision were -0.75 mg/liter and 8.76 mg/liter for population predictions and -0.39 mg/liter and 2.68 mg/liter for individual predictions. In conclusion, a pharmacokinetic model of vancomycin in a very elderly population has been created and validated for predicting plasma concentrations of vancomycin. PMID:27185796

  5. Pharmacokinetics of Vancomycin in Elderly Patients Aged over 80 Years.

    Science.gov (United States)

    Bourguignon, Laurent; Cazaubon, Yoann; Debeurme, Guillaume; Loue, Constance; Ducher, Michel; Goutelle, Sylvain

    2016-08-01

    Since the 1950s, vancomycin has remained a reference treatment for severe infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus Vancomycin is a nephrotoxic and ototoxic drug mainly eliminated through the kidneys. It has a large interindividual pharmacokinetic variability, which justifies monitoring its plasma concentrations in patients. This is especially important in patients aged over 80 years, who frequently have renal impairment. However, the pharmacokinetics of vancomycin in this population is very poorly described in the literature. The objective of this work was to propose a model able to predict the pharmacokinetics of vancomycin in very elderly people. First, a population pharmacokinetic model was carried out using the algorithm NPAG (nonparametric adaptive grid) on a database of 70 hospitalized patients aged over 80 years and treated with vancomycin. An external validation then was performed on 41 patients, and the predictive capabilities of the model were assessed. The model had two compartments and six parameters. Body weight and creatinine clearance significantly influenced vancomycin volume of distribution and body clearance, respectively. The means (± standard deviations) of vancomycin volume of distribution and clearance were 36.3 ± 15.2 liter and 2.0 ± 0.9 liter/h, respectively. In the validation group, the bias and precision were -0.75 mg/liter and 8.76 mg/liter for population predictions and -0.39 mg/liter and 2.68 mg/liter for individual predictions. In conclusion, a pharmacokinetic model of vancomycin in a very elderly population has been created and validated for predicting plasma concentrations of vancomycin.

  6. Self-Reported Health and Functional Characteristics of Mexican and Mexican American Adults Aged 80 and Over

    Science.gov (United States)

    Downer, Brian; Chen, Nai-Wei; Wong, Rebeca; Markides, Kyriakos S.

    2016-01-01

    Objective To examine the health and functional characteristics of Mexican and Mexican American adults aged80. Method Data came from Wave I (2001) and Wave III (2012) of the Mexican Health and Aging Study (MHAS), and Wave IV (2000–2001) and Wave VII (2010–2011) of the Hispanic Established Populations for Epidemiologic Studies of the Elderly (HEPESE). Results In 2000–2001, diabetes, arthritis, hypertension, and stroke were higher in the HEPESE than in the MHAS. In the HEPESE, activities of daily living (ADL) difficulties and all health conditions, except heart attack, were greater in 2010–2011 than in 2000–2001. In the MHAS, hypertension and ADL difficulties were greater, and arthritis was lower in 2012 compared with 2001. In 2010–2011, all self-reported health conditions were higher in the HEPESE compared with the 2012 observation of the MHAS. Discussion The observed differences may reflect worse health for Mexican Americans, health care access, reporting bias, and more selective survival to very old age in Mexico. PMID:27590800

  7. Analysis of complications and outcomes after pulmonary resection in patients aged 80 years or over with non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Wen-bing LI

    2014-10-01

    Full Text Available Objective To explore the therapeutic effect and degree of safety in patients aged 80 years or over with nonsmall cell lung cancer undergoing radical resection. Methods A retrospective survey of 97 elder patients aged 80 years or over, in whom non-small cell lung cancer was pathologically confirmed after partial resection of the lung in Chinese PLA General Hospital from Jan. 2003 to Dec. 2012. The peri-operative features were evaluated, including gender, age, history of smoking, pulmonary function, surgical procedure, histopathologic type, pathologic stage, etc. The relation of the postoperative complications and mortality with the factors mentioned above was analyzed. Results Among all patients, the surgical procedure comprised 36 lobectomies, 31 segmentectomies, and 30 wedge resections. The histopathologic diagnosis showed there were adenocarcinoma in 51 patients, squamous cell carcinoma in 29, large cell carcinoma in 9, adenosquamous cell carcinoma in 6 and neuro-endocrine cell carcinomas in 2. The disease stage was determined as ⅠA in 55 cases, ⅠB in 33, ⅡA in 7, ⅢA in 2. The post-operative complications (POC occurred in 14 of 97 patients (14.4%, and the most common complication was cardiovascular complication (9 cases, followed by pulmonary complication (5 cases. Only two patients died to the complications, one of them was post-operative pneumonia and respiratory failure, and the other one was acute myocardial infarction. The survival rate of the 97 patients was 91.7%, 70.2% and 52.8% at 1, 3 and 5 years, respectively, and in the patients with stage I disease, the survival rate was 93.9%, 73.6% and 54.1%, respectively. Conclusion Advanced age is not a contraindication to radical pulmonary resection in patients over 80 years old suffering from early stage non-small cell lung cancer. DOI: 10.11855/j.issn.0577-7402.2014.10.13

  8. The experience of diagnosis and treatment of breast cancer in women aged over 80%80岁以上妇女乳腺癌诊治体会

    Institute of Scientific and Technical Information of China (English)

    崔学斌; 王宁

    2016-01-01

    Objective Discusses the characteristics of over 80 years old women breast cancer.Method Comparative analysis of clinical data of June 2011 to 2013 December treatment of 56 patients over the age of 80 elderly breast cancer patients (elderly group) and compared with 827 cases of other age breast cancer patients (non elderly group), observe two groups of patients with postoperative situation, chemotherapy, postoperative pathology.Result Age group of patients with postoperative flap necrosis, wound infection, limb edema, venous thrombosis and postoperative hospitalization time and non elderly group, the difference is not significant.Conclusion For more than 80 elderly women breast cancer, as long as the perioperative preparation, control the operation time, surgery is safe, for hormone receptor positie, oral anastrozole can.%目的:探讨80岁以上妇女乳腺癌的术后特点。方法对比分析2011年6月至2013年12月就诊的56例80岁以上乳腺癌患者(高龄组)与同期827例其他年龄乳腺癌患者(非高龄组)的临床资料,观察两组患者的术后情况、放化疗情况、术后病理情况。结果高龄组患者术后皮瓣坏死、切口感染、患侧上肢水肿、静脉血栓以及术后住院时间方面与非高龄组比较,差异不具有显著性。结论对于80岁以上妇女乳腺癌,只要做好围术期准备,控制好手术时间,手术是安全的。

  9. Prevalence of vitamin D inadequacy in European women aged over 80 years.

    Science.gov (United States)

    Bruyère, Olivier; Slomian, Justine; Beaudart, Charlotte; Buckinx, Fanny; Cavalier, Etienne; Gillain, Sophie; Petermans, Jean; Reginster, Jean-Yves

    2014-01-01

    Inadequate vitamin D status is associated with secondary hyperparathyroidism and increased bone turnover and bone loss, which in turn increases fracture risk. The objective of this study is to assess the prevalence of inadequate vitamin D status in European women aged over 80 years. Assessments of serum 25-hydroxyvitamin D levels (25(OH)D) were performed on 8532 European women with osteoporosis or osteopenia of which 1984 were aged over 80 years. European countries included in the study were: France, Belgium, Denmark, Italy, Poland, Hungary, United Kingdom, Spain and Germany. Two cut-offs of 25(OH)D inadequacy were fixed: nmol/L (30 ng/ml) and nmol/L (20 ng/ml). Mean (SD) age of the patients was 83.4 (2.9) years, body mass index was 25.0 (4.0) kg/m(2) and level of 25(OH)D was 53.3 (26.7) nmol/L (21.4 [10.7] ng/ml). There was a highly significant difference of 25(OH)D level across European countries (pnmol/L, respectively. In the 397 (20.0%) patients taking supplemental vitamin D with or without supplemental calcium, the mean serum 25(OH)D level was significantly higher than in the other patients (65.2 (29.2) nmol/L vs. 50.3 (25.2) nmol/L; Pvitamin D (25(OH)D) inadequacy in old European women. The prevalence could be even higher in some particular countries. PMID:24784761

  10. Social relations as determinants of oral health among persons over the age of 80 years

    DEFF Research Database (Denmark)

    Avlund, Kirsten; Holm-Pedersen, Poul; Morse, Douglas E;

    2003-01-01

    OBJECTIVE: To analyze whether social relations during a 7-year follow-up influence oral health among generally healthy, community-dwelling persons over the age of 80 years. METHOD: The present investigation is based on a subsample of 129 dentate community-dwelling individuals from The Kungsholmen...... Elders Oral Health Study (KEOHS), which included data from interviews and oral examinations. Social relations were measured in terms of marital status, living alone, frequency of contacts, number of confidants, and satisfaction with social contacts and with the frequency of contacts. Oral health.......4, 95% CI: 1.0-5.7) than those who continually lived with others, and that persons who were continuously dissatisfied with the frequency of their social contacts were more likely to have root caries than those who reported a sustained satisfaction with the frequency of their social contacts (OR: 2.9, 95...

  11. Characteristics of Atopic Bronchial Asthma in Seniors over 80 Years of Age

    OpenAIRE

    Andrzej Bożek; Marek Filipowski; Andreas Fischer; Jerzy Jarzab

    2013-01-01

    Background. Asthma in the elderly is an important public health problem. The aim of this study was to assess the prevalence and characteristics of asthma in seniors. Materials and Methods. The study involved 105 people of at least 80 years of age (mean age of 84.1 ± 3.9 years) selected from a group of 1860 individuals. Spirometry, the methacholine test, allergy diagnosis, a measurement of exhaled nitric oxide, and administration of the asthma quality of life questionnaire (AQLQ) were performe...

  12. Dental caries in persons over the age of 80 living in Kungsholmen, Sweden: findings from the KEOHS project

    DEFF Research Database (Denmark)

    Morse, Douglas E; Holm-Pedersen, Poul; Holm-Pedersen, Jytte;

    2002-01-01

    The Kungsholmen Elders Oral Health Study (KEOHS) evaluated the oral health status of generally healthy, community-dwelling persons over the age of 80 living in Kungsholmen, an area in central Stockholm. This paper reports findings regarding the prevalence and severity of dental caries among the d...

  13. Smoking and cognitive change from age 11 to age 80

    OpenAIRE

    Deary, Ian J; Pattie, Alison; M. D. Taylor; Whiteman, Martha C; Starr, John M; Lawrence J Whalley

    2003-01-01

    Age related cognitive decline affects people’s quality of life and their ability to live independently. A recent review stated, "[we] are aware of no studies on the relationship between smoking and cognitive decline associated with normal aging or studies of the effect of smoking on cognition in normally aging individuals." Some previous studies examined smoking in relation to pathological cognitive aging, but lacked cognitive data before the initiation of smoking, and used crude clinical cog...

  14. Food Intake of Kansans Over 80 Years of Age Attending Congregate Meal Sites

    Directory of Open Access Journals (Sweden)

    Allisha M. Weeden

    2010-12-01

    Full Text Available As the population of the United States continues to age, it has become increasingly more important to recognize the food intake and eating habits of older adults. The objective of this study was to describe the food group intake, factors predicting food group intake, and the food choices of community-dwelling Kansans, 80 years of age and older who participate in congregate meal programs. Participants completed a short questionnaire querying demographic information, current health status, and dietary supplement use. Participants (n = 113 were then followed up via telephone to complete two 24-hour diet recalls. Data were analyzed to determine adequacy of food group intake and mean intake. Regression analyses were used to determine factors predicting intake and frequency analysis established food typically consumed. Female participants were significantly more likely to consume more fruit servings than males. Intake was low for all five of the food groups, especially dairy. Chronic health conditions and dietary supplement use were consistently predictive factors of the amount of each food group consumed.

  15. To screen or not to screen for peripheral arterial disease in subjects aged 80 and over in primary health care: a cross-sectional analysis from the BELFRAIL study

    Directory of Open Access Journals (Sweden)

    Degryse Jan

    2011-05-01

    Full Text Available Abstract Background Peripheral arterial disease (PAD is common in older people. An ankle-brachial index (ABI Methods A cross-sectional study embedded within the BELFRAIL study. A general practitioner (GP centre, located in Hoeilaart, Belgium, recruited 239 patients aged 80 or older. Only three criteria for exclusion were used: urgent medical need, palliative situation and known serious dementia. The GP recorded the medical history and performed a clinical examination. The clinical research assistant performed an extensive examination including Mini-Mental State Examination (MMSE, Geriatric Depression Scale (GDS-15, Activities of Daily Living (ADL, Tinetti test and the LASA Physical Activity Questionnaire (LAPAQ. ABI was measured using an automatic oscillometric appliance. Results In 40% of patients, a reduced ABI was found. Cardiovascular risk factors were unable to identify patients with low ABI. A negative correlation was found between the number of cardiovascular morbidities and ABI. Cardiovascular morbidity had a sensitivity of 65.7% (95% CI 53.4-76.7 and a specificity of 48.6% (95% CI 38.7-58.5. Palpation of the peripheral arteries showed the highest negative predictive value (77.7% (95% CI 71.8-82.9. The LAPAQ score was significantly lower in the group with reduced ABI. Conclusion The prevalence of PAD is very high in patients aged 80 and over in general practice. The clinical examination, cardiovascular risk factors and the presence of cardiovascular morbidity were not able to identify patients with a low ABI. A screening strategy for PAD by determining ABI could be considered if effective interventions for those aged 80 and over with a low ABI become available through future research.

  16. The strength of two indicators of social position on oral health among persons over the age of 80 years

    DEFF Research Database (Denmark)

    Avlund, Kirsten; Holm-Pedersen, Poul; Morse, Douglas E;

    2005-01-01

    OBJECTIVE: The objective of the present study is to analyze how two dimensions of social position, education and social class, are associated with oral health among generally healthy, community-dwelling persons over the age of 80 years. METHODS: The present investigation is based on a sample of 157...... community-dwelling individuals from The Kungsholmen Elders Oral Health Study (KEOHS) and included data from interviews and oral examinations. Social position was measured by education and social class. Oral health was measured by active coronal caries, active root caries, edentulism and use of dental...... of being edentulous. Further, persons with elementary/ medium education tended to forego regular dental services more than persons with high education. CONCLUSION: The study identified social inequalities in oral health even in a population of independently living, generally healthy very old Swedes...

  17. Predictive Factors for Surgical Intervention in Patients over the Age of 80 with Adhensive Small-Bowel Obstruction.

    Science.gov (United States)

    Lou, Zheng; Yan, Fei-Hu; Hu, Shi-Jie; Meng, Rong-Gui; Zhang, Wei; Yu, En-da; Fu, Chuan-Gang

    2015-12-01

    Adhensive small-bowel obstruction (SBO) remains a common cause of admission to surgical wards around the world. Given the growing elderly population, the number of elderly patients with adhensive SBO can be expected to increase substantially. Timely and appropriate treatment would improve morbidity and mortality rates in elderly patients with adhensive SBO. However, accurately determining which patients should undergo surgical treatment during the hospitalization remains difficult. The aim of this study was to identify predictive factors for surgical intervention in patients aged over 80 years presenting with SBO due to postoperative adhesions. A clinical and radiological data for the assessment of patients presenting with adhensive SBO were collected. A logistic regression model was applied to identify risk factors that would predict the need of surgical intervention. A total of 21 patients (13 males, 8 females) were treated during a 3.5-year period. The mean age was 85.5 ± 4.7 years, ranging from 80 to 97 years. There is no significant difference in age (group 1 87.6 ± 5.9 years vs. group 2 84.8 ± 4.3 years, p = 0.262) between two groups. Serious coexisting diseases were noted in 13 (61.9 %, 13/21) patients. Primary hypertension, cardiac diseases, and diabetes mellitus were common coexisting conditions. However, there is no significant difference in comorbidities (40 vs. 68.8 %, p = 0.325) between group 1 and group 2. Adhensive SBO was successfully treated with conservative treatment in 16 patients (76.2 %, 16/21, group 2), whereas conservative treatment failed in 5 patients (23.8 %, 5/21, group 1), who subsequently underwent laparotomy. Postoperative complication rate was 14.3 % (wound infection, 1/5) and mortality was 0 % (0/5) in group 1. One patient death was recorded in group 2 (1/16, 6.3 %). The overall mean hospital stay was 10.0 ± 5.9 days (range 3-27 days). Group 1 had a longer hospital stay than group 2. However

  18. Functional ability and oral health among older people: a longitudinal study from age 75 to 80

    DEFF Research Database (Denmark)

    Avlund, K; Holm-Pedersen, P; Schroll, M

    2001-01-01

    OBJECTIVE: To examine whether functional ability at age 75 and age 80 is associated with oral health and use of dental services cross-sectionally and whether changes in functional ability from age 75 to age 80 are associated with oral health and regular use of dental services at age 80. DESIGN......: The study included a random sample of 75-year-olds at baseline and a follow-up study 5 years later. The data are treated as two cross-sectional studies at age 75 and 80, respectively, and as a longitudinal study from age 75 to 80. SETTING: The western part of Copenhagen County. PARTICIPANTS: The two cross......-sectional studies of 75- and 80-year-old people included 411 and 321 persons, respectively. The longitudinal study from age 75 to 80 included the 326 persons who participated in both surveys. MEASUREMENTS: Oral health status was measured roughly by number of teeth and chewing ability. Use of dental services...

  19. Association of isokinetic strength with pain and functional status in knee osteoarthritis patients aged 80 years and over%80岁及以上膝骨性关节炎患者等速肌力与疼痛和功能状态的关系

    Institute of Scientific and Technical Information of China (English)

    瓮长水; 郭燕梅; 陈蔚; 黎春华; 王娜

    2014-01-01

    目的 评估80岁及以上膝骨性关节炎(OA)患者膝关节等速肌力与疼痛和功能状态之间的关系. 方法 32例膝OA患者和10例健康受试者作为对照组.对膝OA患者进行视觉模拟评分法(VAS)疼痛强度评分、Lequesne指数.对膝OA组和对照组受试者进行膝关节伸肌和屈肌标准化等速向心收缩测试程序,角速度为60°/s和180°/s,进行功能性移动能力测试:5次坐到站测试(FTSST)、3 m计时起立行走测试(TUGT)和10m计时步行测试(TWT). 结果 膝OA组与对照组受试者在两个角速度的伸肌和屈肌的相对峰力矩之间的比较差异有统计学意义(t=2.747,P<0.05).伸肌相对峰力矩与年龄、Liquesce指数总分、FTSST、TUGT和TWT之间呈负相关(r=-0.39~-0.75,均P<0.05).伸肌相对峰力矩与VAS得分和Lequesne指数疼痛评分之间无相关(r=-0.23~ 0.31,均P>0.05).伸肌相对峰力矩和VAS得分两者是Liquesce指数的重要预测因子,可解释Liquesce指数41%的变异量(adjusted R2=0.41). 结论 80岁及以上膝OA患者肌力损害程度与其功能表现密切关联,股四头肌肌力和疼痛强度是预测失能的重要指标.%Objective To evaluate the difference in isokinetic strength of the knee muscles between knee osteoarthritis (KOA) patients aged 80 years and over and matched healthy controls,and to establish the association of isokinetic strength with pain and functional status in patients with KOA.Methods The study enrolled 32 patients aged 80 and over diagnosed with unilateral knee OA and 10 matched controls.Pain was evaluated by the visual analogue scale (VAS),the pain intensity scale and the Lequesne index for patients with knee OA.Functional status was assessed by the Timed Up and Go Test (TUGT),the Five Times Sit to Stand Test (FTSST) and the Timed 10 Meter Walk Test (TWT).Muscle strength was measured using the isokinetic dynamometer Biodex System 4 Pro.Bilateral isokinetic (concentric) knee flexion and extension with

  20. Clinical features and treatment outcome of very elderly patients over 80 years old with multiple myeloma: comparison with patients in different age groups in the era of novel agents.

    Science.gov (United States)

    Matsue, Kosei; Matsue, Yuya; Fujisawa, Manabu; Fukumoto, Kota; Suehara, Yasuhito; Sugihara, Hiroki; Takeuchi, Masami

    2016-01-01

    We retrospectively analyzed the outcomes of 175 consecutive patients admitted to our hospital between April 2004 and June 2014, and identified 42 (24%), 80 (46%), and 53 (30%) patients ≥ 80, 66-79, and ≤ 65 years old, respectively. The median progression-free survival (PFS) and overall survival (OS) of the ≥ 80, 66-79, and ≤ 65 years old groups were 19.1, 26.3, and 54.3 months, and 31.9, 54.8, and 83.8 months, respectively. Patients ≥ 80 but not ≤ 79 years old with ECOG performance score (PS) ≥ 3 and/or Charlson comorbidity index (CCI) ≥ 5 showed significantly shorter survival. ECOG PS and CCI predicted the treatment outcome of patients ≥ 80 but did not predict ≤ 79 years old.

  1. Risk factors analysis of white matter lesions of different degrees in the elderly aged 80 years and over%高龄老年人不同程度脑白质损害的危险因素分析

    Institute of Scientific and Technical Information of China (English)

    王月菊; 侯宝元; 董凌燕; 李虹; 李建中

    2011-01-01

    Objective To investigate the independent risk factors of cerebral white matter lesions (WML) of different degrees in the elderly aged 80 years and over,and provide the evidences for forecasting the prognosis of WML.Methods Brain magnetic resonance images (MRI) findings in 151 people aged 74 to 93 years were collected and analyzed.According to the severity of WML in brain MRI using the Fazekas Scale,the persons were divided into non-WML (control) group,mildWML (grade 1 WML) group and moderate-to-severe WML (grade 2 WML) group.The cognitive score,vascular risk factors,cerebral hemodynamic and arteriosclerotic index,and radiological features were compared among the three groups.Subsequent one-way ANOVA and multivariate logistic analysis were performed to determine the statistically significant factors and the independent risk factors among groups.Results The statistically significant factors with one-way ANOVA analysis among the three groups were cognitive performance (F = 48.595,P = 0.000),hypertension (x2 =7.052,P=0.029),cigarette history (x2 = 19.476,P= 0.000),cholesterol (TC) (F= 3.086,P=0.049),Crouse score (F=3.968,P=0.021) and multiple cerebral atrophy indexes.When compared with control group,cigarette history (OR 2.031,95%CI 1.244-1.317),lacunar infarction (LI)numbers (OR 2.031,95%CI 1.316-4.015) and cholesterol (OR 1.610,95%CI 0.972-2.668) were independent risk factors in grade 1 WML group (all P<0.05).The independent risk factors between grade 1 and 2 WML group were cognitive performance (OR 0.276,95%CI 0.143-0.532),cigarette history (OR 2.262,95% CI 1.260-4.059),and sylvian fissure ratio (SFR) (OR 1.954,95% CI 1.013-3.768) (all P<0.05).The independent risk factors between the grade 2 WML group and control group were cognitive performance (OR 0.091,95%CI 0.030-0.273),bicoudate ratio (BCR)(OR 2.511,95%CI 1.147-5.499),Crouse score (OR 2.304,95%CI1.127-4.712)and LI numbers (OR 2.200,95%CI 1.028-4.707) (all P<0.05).Conclusions Mild WML patients have no

  2. Activity participation and cognitive aging from age 50 to 80 in the glostrup 1914 cohort

    DEFF Research Database (Denmark)

    Gow, Alan J; Mortensen, Erik L; Avlund, Kirsten

    2012-01-01

    To examine the cognitively protective effect of leisure and physical activities while accounting for prior cognitive ability, a rarely considered confounder of the previously reported associations between activity and cognitive aging.......To examine the cognitively protective effect of leisure and physical activities while accounting for prior cognitive ability, a rarely considered confounder of the previously reported associations between activity and cognitive aging....

  3. Osteoarticular diseases and physical performance of Brazilians over 80 years old

    Directory of Open Access Journals (Sweden)

    Vanessa Ribeiro dos Santos

    2016-02-01

    Full Text Available Abstract Objective To investigate the physical performance of Brazilian individuals older than 80 years with and without OD. Methods The sample consisted of 135 individuals (aged > 80 years of both gender. Identification of osteopenia/osteoporosis was verified by Dual Energy X-ray Absorptiometry, and the presence of others osteoarticular diseases (OD was obtained using a questionnaire of morbidities. Physical performance was analyzed by motor tests. Results Men presented higher proportion of osteopenia/osteoporosis compared to women (p = 0.013. The proportion of older people with arthritis/osteoarthritis for women and men was 33% and 26%, respectively, and with OD in the spine was 19% and 12%, respectively. No significant difference for physical performance, measured by each test and overall score, was observed between groups of OD. According to gender, male with OD presented lower performance in gait speed, balance and overall score (p < 0.05, while older people with osteopenia/osteoporosis are at higher risk for low physical performance (OR 2.73; CI 95% 1.31-5.66. Conclusion In conclusion it was verified in older people with age of 80 years or more, a high prevalence of OD, especially in men, and the presence of these diseases interfered negatively their physical performance.

  4. Does white coat hypertension require treatment over age 80?: Results of the hypertension in the very elderly trial ambulatory blood pressure side project.

    Science.gov (United States)

    Bulpitt, Christopher J; Beckett, Nigel; Peters, Ruth; Staessen, Jan A; Wang, Ji-Guang; Comsa, Marius; Fagard, Robert H; Dumitrascu, Dan; Gergova, Vesselka; Antikainen, Riitta L; Cheek, Elizabeth; Rajkumar, Chakravarthi

    2013-01-01

    White coat hypertension is considered to be a benign condition that does not require antihypertensive treatment. Ambulatory blood pressure (ABP) was measured in 284 participants in the Hypertension in the Very Elderly Trial (HYVET), a double-blind randomized trial of indapamide sustained release 1.5 mg±perindopril 2 to 4 mg versus matching placebo in hypertensive subjects (systolic blood pressure 160-199 mm Hg) aged >80 years. ABP recordings (Diasys Integra II) were obtained in 112 participants at baseline and 186 after an average follow-up of 13 months. At baseline, clinic blood pressure (CBP) exceeded the morning ABP by 32/10 mm Hg. Fifty percent of participants fulfilled the established criteria for white coat hypertension. The highest ABP readings were in the morning (average 140/80 mm Hg), the average night-time pressure was low at 124/72 mm Hg, and the average 24-hour blood pressure was 133/77 mm Hg. During follow-up, the systolic/diastolic blood pressure placebo-active differences averaged 6/5 mm Hg for morning ABP, 8/5 mm Hg for 24-hour ABP, and 13/5 mm Hg for CBP. The lowering of blood pressure over 24 hours supports the reduction in blood pressure with indapamide sustained release±perindopril as the explanation for the reduction in total mortality and cardiovascular events observed in the main HYVET study. Because we estimate that 50% had white coat hypertension in the main study, this condition may benefit from treatment in the very elderly.

  5. [Articular chondrocalcinosis after 80 years of age].

    Science.gov (United States)

    Memin, Y; Monville, C; Ryckewaert, A

    1978-02-01

    In 108 women over 80 (mean age 88,4 years, extremes 80 and 99 years) hospitalized in a geriatric service for various reasons, radiograms were made of both knees in the frontal aspect on standard film to detect calcinosis of the meniscus and chondrocalcinosis of the joint. In 25 women (23.1%) the radiographs revealed calcinosis of the meniscus with or without chondrocalcinosis. In these 25 cases a lateral X-ray was also made of the two knees, frontal X-rays were made of the pelvis, thumbs and shoulders. In 22 cases (88%) these revealed calcification of the fibrocartilages or articular cartilages in joints other than the knee. Seven of the 25 women had at least one attack of articular inflammation (especially of the knee) resembling a pseudo-gout crisis. The frequency of chronic arthropathies resembling arthroses was high in the 25 patients with chondrocalcinosis: 8 (32%) had an internal or external femoro-tibial arthrosis, as against 11 of the 83 patients (13%) of the same age without chondrocalcinosis, a significant difference. Eleven of the 25 women had signs of femororotular arthrosis on the lateral X-rays of the knees, 5 had coxarthrosis (with in 3 cases a radiological image of fibrocartilaginous or coxofemoral cartilaginous calcification). One women had chronic radiocarpal arthropathy evocative or chondrocalcinosis. Ten had a scaphotrapezoidal arthrosis, 5 arthrosis of the shoulder, 3 with radiological aspect of glenohumeral chondrocalcinosis. PMID:644241

  6. 80岁以上慢性心力衰竭患者的综合治疗%The comprehensive therapy for patients aged over 80 years old with chronic heart failure

    Institute of Scientific and Technical Information of China (English)

    黄带发; 贺顺川; 王聿杰; 刘艳霞; 于伟

    2012-01-01

    Objective: To explore the efficacy of comprehensive therapy combined with drug therapy and psychotherapy in patients aged over 80 years with chronic heart failure ( CHF). Methods: Between January 2006 and August 2011, from 52 CHF patients aged over 80 years registered in General Hospital of Shenyang Military Command, 36 patients without physical activity disability were included in this study and divided into sport rehabilitation and control groups (re = 18, each). For control group, the drug therapy and psychotherapy were given based on which exercise rehabilitation was added in sport rehabilitation group. The heart function, psychological state and survival state were compared between the two groups at 3 months after treatment. Results: (1) The BNP value was deceased in both sport rehabilitation and control groups. Nevertheless, no difference was found in BNP value between the two groups ( P > 0. 05 ). The patients with NYHA Class I of heart function were 16 cases and 11 cases in sport rehabilitation and control groups, respectively. However, there was no difference between the two groups (Χ2 =2. 370, P =0. 124). (2)Both 6MWT walking distance and MLHFQ scoring in sport rehabilitation group were better than those in control group ( P 0. 05). (4) By February 2012, 38 patients still survived among a total of 52 patients. Notably, 3 cases were found with more than 5 years of disease period. The remaining 14 dead patients were all long-term bed patients. For sport rehabilitation group, the hospitalization time and times were relatively less as compared with control group (P<0.05). Conclusion: Drug therapy combined with exercise rehabilitation and psychotherapy could improve the heart function and survival quality and shorten the hospitalization time and times. Nevertheless, the further observation was still required in the following-up.%目的:探讨药物结合运动、心理康复治疗的综合方案对80岁以上心力衰竭患者的效果.方法:选择2006年1

  7. CT STUDY COMPARING SULCAL CHANGES AND THIRD VENTRICLE SIZE AS AGE PROGRESSES FROM 40 TO 80

    Directory of Open Access Journals (Sweden)

    Vinu C

    2014-09-01

    Full Text Available INTRODUCTION: Computerized tomography, also called CT combines a series of X-ray views taken from many different angles and computer processing to create cross-sectional images of the bones and soft tissues inside your body. It has brought about tremendous changes in the field of diagnostic and research medicine. Here CT is used to measure the various dimensions of 6 selected sulci of brain and third ventricle. With the recent advances in technology, sulcal pattern and development is being studied extensively to understand the functioning of brain. There is evidence of sulcal dimensional changes as age of an individual progress. This may be responsible for behavioral or intellectual changes in a individual. Through this study I intend to understand how the sulcal dimension may vary with the help of CT scans. 6 sulci were selected and their width was measured in 80 individuals between the age group of 40 and 80. Through statistical analysis the data will reveal any recognizable changes in the width of the selected sulcus with progression of age. The third ventricle size may also be influenced by the age of the individual. Using the help of CT scan I am intending to measure the dimensions of the third ventricle. Recent studies have shown that size and volume of the third ventricle have significant role in the geriatric population. AIMS AND OBJECTIVES: To study the age related changes in the width of left and right central sulcus, superior temporal sulcus, parieto-occipital sulcus and to study the age related changes in third ventricle depth, length and width through the use of CT scans. STUDY SETTINGS: A cross-sectional study comprising of 60 patients coming to the radiology department for the C T scan. The CT scans for the study were taken randomly between the ages of 40 to 80. RESULTS: The purpose of the study was to study the changes in the dimensions of sulci and the third ventricle of the brain. Hypothesis was that the sulcal width increases

  8. [Myocardial infarction in patients aged 70 years and over].

    Science.gov (United States)

    Dutoit, A; Mahieu, G; Petit, A; Cabaret, P; Jacquemart, T; Rihani, R; Graux, P; Cornaert, P; Croccel, L

    1990-09-01

    109 subjects aged 70 years (58 women, 51 men; average age 77 years) were hospitalized in the CICU (Cardiology Intensive Care Unit) over the period stretching from 1984 to 1986. The average length of stay in the CICU was 1 week, completed by an average stay of 5 days in the cardiology department. 100 per cent of the patients were followed up. Of the clinical parameters made evident by this study, the authors note that hypertension was the predominant risk factor (52.2 per cent); a history of coronary disease was noted in 60.5 per cent; 26.6 per cent of the patients were hospitalized before the 6th hour, chest pain being typical in 78 per cent versus painless in 11 per cent of patients; topographically, the infarction was anterior in 55 per cent, posterior in 40.4 per cent, and around the circumference in 4.6 per cent of cases; 80.8 per cent of the infarctions were transmural versus 19.2 per cent of infarctions without the Q wave--the latter accounted for a higher hospital mortality rate (38 per cent versus 27.3 per cent). The main complications were disturbances in rhythm (60.6 per cent) and LVI (56.9 per cent). Complications on the form of infections were noted in 15.6 per cent. Apart from the usual indicators of severity (cardiogenic shock, VF, LVI), infarction of the RV and AF had a serious effect on the prognosis. latrogenic disease accounted for 18.9 per cent. From the point of view of prognosis, hospital mortality was 30 per cent; mortality after one year was 44 per cent and 47.7 per cent after 2 years (in a group of 76 subjects).(ABSTRACT TRUNCATED AT 250 WORDS) PMID:2264704

  9. Influence of aging modes on microstructure and mechanical properties of AZ80 magnesium alloy

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The microstructure and mechanical properties of AZ80 magnesium alloy after solid solution and aging treatments were studied by using optical microscope (OM), X-ray diffraction (XRD), scanning electron microscopy(SEM) as well as tensile testing. The results indicated that β-Mg17Al12 phase was getting to distribute discontinuously along the grain boundary after treated at 395℃ ageing for 12 h followed by water-cooling, but it did not dissolve into α-Mg completely. The residual β-Mg17Al12 phase distributed along the grain boundary and had block-like or island shapes. The size of α-Mg was getting to be coarsening but not significantly. The β-Mg17Al12 precipitates appeared in discontinuous and continuous patterns from supersaturated α-Mg solid solution after aged at 200℃. The precipitation patterns were associated with the aging time essentially. The tensile strength and elongation of the alloy increased significantly but the hardness and yield strength decreased after solid solution treatment. However, with the prolonging of aging time, the hardness and strength of alloy increased while the ductility decreased.

  10. Prognosis of primary care patients aged 80 years and older with lower respiratory tract infection

    NARCIS (Netherlands)

    van de Nadort, Christiana; Smeets, Hugo M; Bont, Jettie; Zuithoff, N Peter A; Hak, Eelko; Verheij, Theo J M

    2009-01-01

    BACKGROUND: Predictors for a complicated course of a lower respiratory tract infection (LRTI) episode among patients aged > or =80 years are unknown. AIM: To determine prognostic factors for hospital admission or death within 30 days after first onset of LRTI among primary care patients aged > or =8

  11. Incidence and Effects of Polypharmacy on Clinical Outcome among Patients Aged 80+: A Five-Year Follow-Up Study

    OpenAIRE

    Rong Wang; Lei Chen; Li Fan; Dewei Gao; Zhiru Liang; Jing He; Weiqin Gong; Linggen Gao

    2015-01-01

    Objectives Polypharmacy is a problem of growing interest in geriatrics with the increase in drug consumption in recent years, is defined according to the WHO criteria as the, ‘‘concurrent use of five or more different prescription medication”. We investigated the clinical characteristics of polypharmacy and identified the effects of polypharmacy on clinical outcome among patients aged 80+ admitted to Chinese PLA general hospital. Methods Older men aged80 years (n = 1562) were included in th...

  12. Hospital mortality of patients aged 80 and older after surgical repair for type A acute aortic dissection in Japan

    Science.gov (United States)

    Ohnuma, Tetsu; Shinjo, Daisuke; Fushimi, Kiyohide

    2016-01-01

    Abstract To evaluate whether patients aged 80 and older have higher risk of hospital mortality after repair of type A acute aortic dissection (TAAAD). Emergency surgery for TAAAD in patients aged 80 and older remains a controversial issue because of its high surgical risk. Data from patients who underwent surgical repair of TAAAD between April 2011 and March 2013 were retrospectively extracted from the Japanese Diagnosis Procedure Combination database. The effect of age on hospital mortality was evaluated using multivariate logistic regression analysis. A total of 5175 patients were enrolled. The mean age of patients was 67.1 ± 13.0 years, and the male:female ratio was 51:49. Patients aged 80 and older more frequently received tracheostomy than their younger counterparts (9.5% vs 5.4%, P <0.001). Intensive care unit and hospital stays were significantly longer in the elderly cohort versus the younger cohort (7.6 vs 6.7 days, P <0.001, and 42.2 vs 35.8 days, P <0.001, respectively). Logistic regression analysis showed that age80 years was significantly associated with a higher risk of hospital mortality (adjusted odds ratio, 1.62; 95% confidence interval, 1.28–2.06; P <0.001). In linear regression analysis, age80 years was also significantly associated with longer hospital stay (P = 0.007). In a large, nationwide, Japanese database, patients aged 80 and older were at increased risk of hospital mortality and length of hospital stay. PMID:27495057

  13. Hospital mortality of patients aged 80 and older after surgical repair for type A acute aortic dissection in Japan.

    Science.gov (United States)

    Ohnuma, Tetsu; Shinjo, Daisuke; Fushimi, Kiyohide

    2016-08-01

    To evaluate whether patients aged 80 and older have higher risk of hospital mortality after repair of type A acute aortic dissection (TAAAD).Emergency surgery for TAAAD in patients aged 80 and older remains a controversial issue because of its high surgical risk.Data from patients who underwent surgical repair of TAAAD between April 2011 and March 2013 were retrospectively extracted from the Japanese Diagnosis Procedure Combination database. The effect of age on hospital mortality was evaluated using multivariate logistic regression analysis.A total of 5175 patients were enrolled. The mean age of patients was 67.1 ± 13.0 years, and the male:female ratio was 51:49. Patients aged 80 and older more frequently received tracheostomy than their younger counterparts (9.5% vs 5.4%, P <0.001). Intensive care unit and hospital stays were significantly longer in the elderly cohort versus the younger cohort (7.6 vs 6.7 days, P <0.001, and 42.2 vs 35.8 days, P <0.001, respectively). Logistic regression analysis showed that age80 years was significantly associated with a higher risk of hospital mortality (adjusted odds ratio, 1.62; 95% confidence interval, 1.28-2.06; P <0.001). In linear regression analysis, age80 years was also significantly associated with longer hospital stay (P = 0.007).In a large, nationwide, Japanese database, patients aged 80 and older were at increased risk of hospital mortality and length of hospital stay. PMID:27495057

  14. Outcome and Risk Factors Presented in Old Patients Above 80 Years of Age Versus Younger Patients After Ischemic Stroke

    DEFF Research Database (Denmark)

    Bentsen, Line; Christensen, Louisa; Christensen, Anders;

    2014-01-01

    BACKGROUND: Older patients are associated with increased stroke prevalence, worse outcome, and risk of undertreatment in comparison with younger patients. The aim of the present study was to compare risk factor distribution and functional outcome in stroke survivors older and younger than 80 years...... age or older of whom the majority were women (P factors vary significantly...... with age, suggesting different stroke mechanisms. Patients older than 80 years experience more severe strokes and frequently have minor impairments before stroke. The increase in impairment after stroke is comparable with what is observed in younger patients, suggesting that good recovery after stroke may...

  15. Percutaneous nephrolithotomy in very elderly patients (Age 75 and Over

    Directory of Open Access Journals (Sweden)

    Hüseyin Çelik

    2015-12-01

    Full Text Available Objective: Percutaneous nephrolithotomy (PNL is a minimally invasive method used safely in surgical treatment of kidney stones in the world. The first PNL surgery performed in our clinic in March 1998 and first PNL surgery was performed in June 2000 over the age of seventy which was bilaterally side. In our study, PNL operations performed for 75 years and older patients were examined. Methods: PNL operations were performed under the general anesthesia. After cystoscopy in the supine position, ureteral catheter was inserted accompanied by C-arm fluoroscopy. Afterwards, patients were taken prone position then we entered into the kidney with a metal needle with fluoroscopic on. We dilated the entrance with Amplatzer renal dilatators set until the 30 F. After the procedure, the nephrostomy catheter was placed in the renal sheath. 4 mm residual fragments after the PNL operation were accepted as clinically insignificant stone residues (CIRF. Results: 3003 PNL procedures were performed between dates March 1998 - December 2014 in total 16 years. 28 patients of total were 75 years and over. 29 PNL surgeries performed to these patients, including one bilateral PNL procedure. Mean age was 79.36 years (75-88. Twenty (74% of the patients were concluded stone free. 2 patients had tubeless PNL surgery. There was no another complication. Conclusion: PNL is a minimally invasive method has became advantageous according to open surgery because of higher safety, lower complication rates, shorter hospitalization stay, more patient comfort and higher stone free rates. PNL is a safe and effective method in the surgical treatment of urinary tract stone diseases.

  16. Antidepressant Use in Persons Aged 12 and Over: United States, 2005-2008

    Science.gov (United States)

    ... Order from the National Technical Information Service NCHS Antidepressant Use in Persons Aged 12 and Over: United ... in 10 Americans aged 12 and over takes antidepressant medication. 1 Significantly different from age group 18– ...

  17. Nutrition study people over 80 years

    Directory of Open Access Journals (Sweden)

    Javier Benítez

    2012-12-01

    Full Text Available La soledad siempre se ha asociado como factor de riesgo en la vejez. La población de personas mayores de 80 años que viven solas son el objetivo de estudio para determinar su situación y potencial para poder mejorar su calidad de vida. Objetivos: Determinar el estatus nutricional de la población mayor de 80 años que vive sola en el área de “La Laguna” en Cádiz. Material y métodos: El programa PIAMLA’80 analiza estos parámetros y sus posibles correlaciones en un grupo de 342 sujetos. Se han medido diferentes valores como test de Barthel, Lawton-Brody, Lobo, Gijón, MNA y valores bioquímicos sanguíneos. Resultados: En una población de 984 sujetos, fueron seleccionados inicialmente 342, pero finalmente el grupo disminuyó a 247. La media de Barthel fue de 80,42 puntos, 5,76 para el Lawton, 11,3 para Gijón y 26,48 para Lobo. El MNA para la población total fue de 24,25/30, detectando solo un grupo de riesgo en mujeres de 85 a 95 años. La correlación entre nutrición y parámetros analíticos fue positiva para Hemoglobina (0,19, proteínas totales (0,26, Hierro (0,32 y albúmina (0,46. Conclusiones: En nuestro estudio no hemos detectado malnutrición en ningún rango de edad ni género. El uso del test MNA debe generalizarse como rápido, fácil y efectivo.

  18. Efficacy and safety of thrombolysis in patients aged 80 years or above with major acute ischemic stroke

    OpenAIRE

    Sang-Chul Kim; Keun-Sik Hong; Yong-Jin Cho; Joong-Yang Cho; Hee-Kyung Park; Pamela Song

    2012-01-01

    Background: Elderly patients with major ischemic strokes may remain severely disabled or dead. However, efficacy and safety of thrombolysis in this have not been fully explored. Materials and Methods: Data from the case records of patients aged >80 years with acute ischemic stroke with admission National Institute of Health Stroke Scale (NIHSS) score ≥10 admitted between April 2009 and May 2011 were retrieved. Outcomes in patients treated with thrombolysis and control subjects were compared. ...

  19. Elemental Compositions of Over 80 Cell Phones

    Science.gov (United States)

    Christian, Beverley; Romanov, Alexandre; Romanova, Irina; Turbini, Laura J.

    2014-11-01

    Over the last few years, 85 cell phones have been disassembled, ground up, dissolved, and analyzed for elemental content, mainly for information about the metals present in the phones, but also for some metalloids and nonmetals. The following list of 38 elements were detected in some or all of the phones: Be, B, Mg, Al, Ti, V, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Y, Nb, Pd, Ag, In, Sn, Sb, Te, Ba, Ta, W, Pt, Au, Tl, Pb, Bi, Pr, Nd, Sm, Eu, Gd, Tb, Dy, and Er. Cadmium was never detected. This paper discusses the methods used for carrying out the analysis, proposes possible sources in the telephones for the elements of interest, the reasons for the interest in most of the elements, and method repeatability.

  20. Prevalence and risk factors of atrial fibrillation in preterminal inpatients aged 60 years and over

    Institute of Scientific and Technical Information of China (English)

    YANG Jie-fu; LIU Bing; LIU Dong-ge; LUO Yao; FANG Fang

    2008-01-01

    Background Atrial fibrillation is a common arrhythmia and a major risk factor for ischaemic stroke. We investigated the prevalence of atrial fibrillation and its relation to age, gender and underlying heart disease in patients aged 60 years and over who died during hospitalization.Methods Between 1955 and 2005, 1519 autopsies of in-hospital deaths in Beijing Hospital were performed. Among them, 540 cases met criteria of age ≥60 years and full clinical history including electrocardiogram, echocardiogram, myocardial perfusion images and detailed cardiac pathology records from autopsy.Results Atrial fibrillation occurred in 193 of 540 patients and prevalence increased with age (10.5% in patients younger than 60 years, 39.6% (80-89 years) and 54.8% (≥90 years)) being higher in patients with underlying heart disease than without heart disease (P<0.0001). Coronary artery disease (CAD), congestive heart failure, cardiac valve dysfunction and chronic renal failure were associated with a higher prevalence of atrial fibrillation (P<0.001). CAD with anterior myocardial infarction or left anterior descending artery disease was also associated with an increased prevalence of atrial fibrillation (P <0.05). Following autopsy, clinical misdiagnosis of CAD increased with age and missed clinical diagnosis of CAD decreased with age. Multivariate Logistic regression analysis revealed independent predictors of atrial fibrillation: age (OR=1.335, 95% Cl: 1.114-1.600, P<0.0001), underlying heart disease (OR=2.019, 95% CI: 1.244-3.278, P <0.005), chronic heart failure (OR=1.873, 95% CI: 1.272-2.757, P <0.005), mitral regurgitation (OR=2.163, 95% Cl: 1.093-4.278, P<0.05) and mitral stenosis (OR=33.575, 95% CI: 2.852-395.357, P<0.05). Conclusions A high prevalence of atrial fibrillation was found in Chinese patients

  1. Patients Aged 80 Years or Older are Encountered More Potentially Inappropriate Medication Use

    OpenAIRE

    Li Mo; Ding Ding; Shi-Yun Pu; Qin-Hui Liu; Hong Li; Bi-Rong Dong; Xiao-Yan Yang; Jin-Han He

    2016-01-01

    Background: Polypharmacy and potentially inappropriate medications (PIMs) are prominent prescribing issues in elderly patients. This study was to investigate the different prevalence of PIM use in elderly inpatients between 65-79 years of age and 80 years or older, who were discharged from Geriatric Department in West China Hospital. Methods: A large-scale cohort of 1796 inpatients aged 65 years or over was recruited. Respectively, 618 patients were 65-79 years and 1178 patients were 80 y...

  2. Prediction of beta-turns at over 80% accuracy based on an ensemble of predicted secondary structures and multiple alignments

    Directory of Open Access Journals (Sweden)

    Kurgan Lukasz

    2008-10-01

    Full Text Available Abstract Background β-turn is a secondary protein structure type that plays significant role in protein folding, stability, and molecular recognition. To date, several methods for prediction of β-turns from protein sequences were developed, but they are characterized by relatively poor prediction quality. The novelty of the proposed sequence-based β-turn predictor stems from the usage of a window based information extracted from four predicted three-state secondary structures, which together with a selected set of position specific scoring matrix (PSSM values serve as an input to the support vector machine (SVM predictor. Results We show that (1 all four predicted secondary structures are useful; (2 the most useful information extracted from the predicted secondary structure includes the structure of the predicted residue, secondary structure content in a window around the predicted residue, and features that indicate whether the predicted residue is inside a secondary structure segment; (3 the PSSM values of Asn, Asp, Gly, Ile, Leu, Met, Pro, and Val were among the top ranked features, which corroborates with recent studies. The Asn, Asp, Gly, and Pro indicate potential β-turns, while the remaining four amino acids are useful to predict non-β-turns. Empirical evaluation using three nonredundant datasets shows favorable Qtotal, Qpredicted and MCC values when compared with over a dozen of modern competing methods. Our method is the first to break the 80% Qtotal barrier and achieves Qtotal = 80.9%, MCC = 0.47, and Qpredicted higher by over 6% when compared with the second best method. We use feature selection to reduce the dimensionality of the feature vector used as the input for the proposed prediction method. The applied feature set is smaller by 86, 62 and 37% when compared with the second and two third-best (with respect to MCC competing methods, respectively. Conclusion Experiments show that the proposed method constitutes an

  3. Patients Aged 80 Years or Older are Encountered More Potentially Inappropriate Medication Use

    Institute of Scientific and Technical Information of China (English)

    Li Mo; Ding Ding; Shi-Yun Pu; Qin-Hui Liu; Hong Li; Bi-Rong Dong; Xiao-Yan Yang

    2016-01-01

    Background: Polypharmacy and potentially inappropriate medications (PIMs) are prominent prescribing issues in elderly patients.This study was to investigate the different prevalence of PIM use in elderly inpatients between 65-79 years of age and 80 years or older, who were discharged from Geriatric Department in West China Hospital.Methods: A large-scale cohort of 1796 inpatients aged 65 years or over was recruited.Respectively, 618 patients were 65-79 years and 1 178 patients were 80 years or older.Updated 2012 Beers Criteria by the American Geriatric Society was applied to assess the use of PIM among the investigated samples.Results: A review of the prescribed medications identified 686 patients aged 80 years or older consumed at least one PIM giving a rate of 58.2%.Conversely, 268 (43.4%) patients aged 65-79 years consumed at least one PIM (x2 =40.18, P < 0.001).Patients aged 80 years or older had higher hospitalization expenses, length of stay, co-morbidities, medical prescription, and mortality than patients aged 65-79 years (all with P < 0.001).Patients aged 80 years or older were prescribed with more benzodiazepines, drugs with strong anticholinergic properties, megestrol, antipsychotics, theophylline, and aspirin.In multiple regression analysis, PIM use was significantly associated with female gender, age, number of diagnostic disease, and number of prescribed medication.Conclusions: The finding from this study revealed that inpatients aged 80 years or older encountered more PIM use than those aged 65-79 years.Anticholinergic properties, megestrol, antipsychotics, theophylline, and aspirin are medications that often prescribed to inpatients aged 80 years or older.Doctors should carefully choose drugs for the elderly, especially the elderly aged 80 years or older.

  4. Health screening - women - over age 65

    Science.gov (United States)

    Health maintenance visit - women - over age 65; Physical exam - women - over age 65; Yearly exam - women - over age 65; Checkup - women - over age 65; Women's health - over age 65; Preventive care exam - women - over ...

  5. A longitudinal study of gender differences in depressive symptoms from age 50 to 80

    DEFF Research Database (Denmark)

    Barefoot, J C; Mortensen, Erik Lykke; Helms, M J;

    2001-01-01

    in women than in men at ages 50 and 60, but not at age 80. Men showed increases in depressive symptoms from age 60 to 80, but women did not (interaction p genders. Potential explanations include differential...

  6. Incidence and Effects of Polypharmacy on Clinical Outcome among Patients Aged 80+: A Five-Year Follow-Up Study.

    Directory of Open Access Journals (Sweden)

    Rong Wang

    Full Text Available Polypharmacy is a problem of growing interest in geriatrics with the increase in drug consumption in recent years, is defined according to the WHO criteria as the, ''concurrent use of five or more different prescription medication". We investigated the clinical characteristics of polypharmacy and identified the effects of polypharmacy on clinical outcome among patients aged 80+ admitted to Chinese PLA general hospital.Older men aged80 years (n = 1562 were included in this study. The included participants attended a structured clinical examination and an interview carried out by a geriatrician and trained nurses. A follow-up survey in 2014 was carried out on survivors in the same way as in 2009. The clinical outcome measured were adverse drug reactions, falls, frailty, disability, cognitive impairment, mortality. The association between polypharmacy and clinical outcome was assessed by logistic regression.The mean (range age of the included participants was 85.2 (80-104 years. Medication exposure was reported by 100% of the population. Mean number of medications reported in this population was 9.56±5.68. The prevalence of polypharmacy (≥6 medications in the present study was 70%. At the time of the follow-up survey, an increase in the number of taken medicines had occurred among half of the survivors. The risk of different outcomes in relation to number of medications rises significantly, the odds ratios were 1.21 (95% confidence interval [CI]1.17-1.28 for adverse drug reactions, 1.18 (95% CI 1.10-1.26 for falls, 1.16 (95% CI 1.09-1.24 for disability, and 1.19 (95% CI 1.12-1.23 for mortality. There was no association between increasing number of medications and cognitive impairment.Our study demonstrates that polypharmacy is very common in the very old patients, and observed that number of medications was a factor associated with difference clinical outcome independently of the age, type of medications prescribed and accompanied

  7. Household Portfolios and Risk Bearing over Age and Time

    OpenAIRE

    Alessandro Bucciol; Raffaele Miniaci

    2011-01-01

    We exploit the US Survey of Consumer Finances from 1998 to 2007 to study households’ portfolio risk bearing. We compare four alternative measures of risk, two based on a financial portfolio and two based on a broader portfolio also including – as illiquid assets – human capital, real estate, business wealth and related debt. The measures provide a different ranking of household risk bearing, but they consistently show that risk bearing fell after 2001, and it positively correlates with wealth...

  8. CEREBROCARDIAC SYNDROME ON PATIENTS OF OVER SEVENTY AGE AND EEG STUDY

    Institute of Scientific and Technical Information of China (English)

    LIU Mingshun; MEI Fengjun; LI Fengluan; LIU Qingrui; GU Lanjie

    2005-01-01

    Objectives: To observe cerebrocardiac syndrome on patients of the over seventy age and it's change of EEG. Methods: Brain CT and ECG were examined in 50 patients of the over seventy age with cerebrocardiac syndrome. Results: There were obvious changes in the brain CT and ECG. Conclusion:There were obvious changes of brain CT and ECG in cerebrocardiac syndrome of over seventy age patients.

  9. Patients Aged 80 Years or Older are Encountered More Potentially Inappropriate Medication Use

    Directory of Open Access Journals (Sweden)

    Li Mo

    2016-01-01

    Conclusions: The finding from this study revealed that inpatients aged 80 years or older encountered more PIM use than those aged 65-79 years. Anticholinergic properties, megestrol, antipsychotics, theophylline, and aspirin are medications that often prescribed to inpatients aged 80 years or older. Doctors should carefully choose drugs for the elderly, especially the elderly aged 80 years or older.

  10. Constant mortality and fertility over age in Hydra

    DEFF Research Database (Denmark)

    Schaible, R.; Scheuerlein, A.; Danko, M. J.;

    2015-01-01

    expectancy of Hydra in the wild. A high proportion of stem cells, constant and rapid cell turnover, few cell types, a simple body plan, and the fact that the germ line is not segregated from the soma are characteristics of Hydra that may make nonsenescence feasible. Nonsenescence may be optimal because...

  11. The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency.

    Directory of Open Access Journals (Sweden)

    Erwin Reiling

    Full Text Available Ku80 and DNA-PKCS are both involved in the repair of double strand DNA breaks via the nonhomologous end joining (NHEJ pathway. While ku80-/- mice exhibit a severely reduced lifespan and size, this phenotype is less pronounced in dna-pkcs-/- mice. However, these observations are based on independent studies with varying genetic backgrounds. Here, we generated ku80-/-, dna-pkcs-/- and double knock out mice in a C57Bl6/J*FVB F1 hybrid background and compared their lifespan, end of life pathology and mutation frequency in liver and spleen using a lacZ reporter. Our data confirm that inactivation of Ku80 and DNA-PKCS causes reduced lifespan and bodyweights, which is most severe in ku80-/- mice. All mutant mice exhibited a strong increase in lymphoma incidence as well as other aging-related pathology (skin epidermal and adnexal atrophy, trabacular bone reduction, kidney tubular anisokaryosis, and cortical and medullar atrophy and severe lymphoid depletion. LacZ mutation frequency analysis did not show strong differences in mutation frequencies between knock out and wild type mice. The ku80-/- mice had the most severe phenotype and the Ku80-mutation was dominant over the DNA-PKCS-mutation. Presumably, the more severe degenerative effect of Ku80 inactivation on lifespan compared to DNA-PKCS inactivation is caused by additional functions of Ku80 or activity of free Ku70 since both Ku80 and DNA-PKCS are essential for NHEJ.

  12. Efficacy and safety of thrombolysis in patients aged 80 years or above with major acute ischemic stroke

    Directory of Open Access Journals (Sweden)

    Sang-Chul Kim

    2012-01-01

    Full Text Available Background: Elderly patients with major ischemic strokes may remain severely disabled or dead. However, efficacy and safety of thrombolysis in this have not been fully explored. Materials and Methods: Data from the case records of patients aged >80 years with acute ischemic stroke with admission National Institute of Health Stroke Scale (NIHSS score ≥10 admitted between April 2009 and May 2011 were retrieved. Outcomes in patients treated with thrombolysis and control subjects were compared. Primary outcome was 3-month modified Rankin Scale (mRS score 0-2. Secondary outcomes were 3-month mRS score 0-3, mRS score 5-6, mortality, and improvement NIHHS score at discharge. Safety outcome was hemorrhagic transformation. Results: Study subjects included 22 patients treated with thrombolysis and 23 controls not treated with thrombolysis. Age, stroke severity, and proportion of identified major vessel occlusions were the variables for comparison between the two groups. More patients in the thrombolyzed group had mRS 0-2 outcome than in non-thrombolyzed group (18.2% vs. 0%; P = 0.049. Proportion of patients with mRS 0-3 outcome was also higher in thrombolyzed group than in non-thrombolyzed group (22.7% vs. 0%; P = 0.022. Patients in the thrombolyzed group had higher mortality, non-significant when compared to patients in the non-thrombolyzed group (18.2% vs. 8.7%; P = 0.414. However, lesser number of patients in the thrombolyzed group had mRS 5-6 outcome (35% vs. 65%; P = 0.075. Median improvement in NIHSS score at discharge also showed a more favorable trend in thrombolyzed group (10 vs. 2; P = 0.082. Rates of symptomatic and asymptomatic hemorrhagic transformations in thrombolyzed group were 4.5% and 27.3% respectively. Conclusion: For elderly patients with major ischemic strokes, thrombolysis offers a greater chance of functional independence.

  13. Multiple Chronic Conditions among Adults Aged 45 and Over: Trends Over the Past 10 Years

    Science.gov (United States)

    ... needs and use for Medicare and other payers. Keywords: hypertension, diabetes, cancer, prevalence The percentage of adults ... with two or more chronic conditions had increasing difficulty obtaining needed medical care and prescription drugs because ...

  14. Three-year changes in leisure activities are associated with concurrent changes in white matter microstructure and perceptual speed in individuals aged 80 years and older.

    Science.gov (United States)

    Köhncke, Ylva; Laukka, Erika J; Brehmer, Yvonne; Kalpouzos, Grégoria; Li, Tie-Qiang; Fratiglioni, Laura; Bäckman, Lars; Lövdén, Martin

    2016-05-01

    Accumulating evidence suggests that engagement in leisure activities is associated with favorable trajectories of cognitive aging, but little is known about brain changes related to both activities and cognition. White matter microstructure shows experience-dependent plasticity and declines in aging. Therefore, we investigated the role of change in white matter microstructure in the activities-cognition link. We used repeated assessments of engagement, perceptual speed, and white matter microstructure (probed with diffusion tensor imaging) in a population-based sample of individuals over 80 years without dementia (n = 442, Mage = 85.1; n = 70 for diffusion tensor imaging; 2 occasions 3 years apart). Using multivariate latent change modeling, we observed positive correlations among changes in predominantly social activities, white matter microstructure, and perceptual speed. Interindividual differences in change in white matter microstructure statistically accounted for the association between change in leisure activities and change in perceptual speed. However, as analyses are based on observational data from 2 measurement occasions, causality remains unclear.

  15. The impact and effectiveness of pneumococcal vaccination in Scotland for those aged 65 and over during winter 2003/2004

    Directory of Open Access Journals (Sweden)

    Macfarlane Tatania V

    2008-04-01

    Full Text Available Abstract Background For winter 2003/2004 in Scotland, it was recommended that all those aged 65 and over be eligible to receive 23-valent polysaccharide pneumococcal vaccine (23vPPV, which has been shown to be effective in reducing the risk of invasive pneumococcal disease (IPD. We assessed the success of the vaccination programme by examining the age specific incidence rates of IPD compared to four previous winter seasons and estimating vaccination effectiveness. Methods Winter season incidence rates of IPD for vaccine targeted (65 years and over and non-targeted (0–4, 5–34, 35–49, 50–64 age bands were examined for the Scottish population in a retrospective cohort design for winter 2003/2004. Details of all IPD cases were obtained from the central reference laboratory and population vaccine uptake information was estimated from a GP sentinel practice network. Based on the preceding four winter seasons, standardised incidence ratios (SIR for invasive pneumococcal disease were determined by age-band and sex during winter 2003/2004. Vaccination effectiveness (VE was estimated using both screening and indirect cohort methods. Numbers needed to vaccinate were derived from VE results using equivalent annual incidence estimates for winter 2003/2004. Results Overall vaccination effectiveness using the screening method (adjusted for age and sex in those aged 65 and over was 61.7% (95%CI: 45.1, 73.2 which corresponded to a number needed to vaccinate of 5206 (95%CI: 4388, 7122 per IPD case prevented. Estimated effectiveness for the same age group using the indirect cohort method was not significant at 51% (95%CI: -278, 94. Reductions in the winter season incidence rate of IPD were highly significant for all those aged 75+: males SIR = 58.8 (95%CI: 41.6, 80.8; females SIR = 70.0 (95%CI: 55.1, 87.8. In the 65–74 years age-group, the reduction for females was significant: SIR = 60.3 (95%CI: 39.3, 88.4, but not for males: SIR = 74.8 (95%CI: 50

  16. Imparting digital skills to people aged 55 years and over in the UK

    OpenAIRE

    Minocha, Shailey; McNulty, Catherine; Evans, Shirley

    2015-01-01

    This research has been conducted by The Open University, UK and has been inspired by the authors’ association with Age UK Milton Keynes. Our aim has been to present a case for imparting digital skills to people aged over 55 years of age, and to present strategies, which partnerships of academic institutions, businesses, and organisations in the voluntary sector (e.g. Age UK, Carers UK) could take forward. Some of our recommendations include: •the need for more robust evidence for the...

  17. Cochlear Implants in Subjects Over Age 65: Quality of Life and Audiological Outcomes.

    Science.gov (United States)

    Aimoni, Claudia; Ciorba, Andrea; Hatzopoulos, Stavros; Ramacciotti, Giulia; Mazzoli, Manuela; Bianchini, Chiara; Rosignoli, Monica; Skarżyński, Henryk; Skarżyński, Piotr H

    2016-01-01

    BACKGROUND Cochlear implants (CIs) have been recognized as a safe and effective means for profound hearing loss rehabilitation in children and adults and recently their use has been extended to subjects over 65 years of age. The aim of this paper was to assess indices related to changes in the quality of life (QoL) in elderly CI recipients. MATERIAL AND METHODS A case-control paradigm was used to assess the effects of CIs on the QoL. Forty-two subjects were assigned to the Case group and 15 subjects to the Control group. All 57 subjects were affected by profound hearing loss and had received a CI. Audiological data were collected from both groups at: (i) 1 month pre-implantation [T1]; (ii) 1 day pre- implantation [T2]; (iii) 30 days post-implantation, with CI used in free field [T3]; and (iv) 12 months post-implantation, with CI used in a free field [T4]. The QoL was assessed via a Glasgow Benefit Inventory (GBI) questionnaire, adapted to otolaryngology. To compare subjects across different ages with varying degrees of speech development, a perception parameter was used from the Speech Perception Categories test developed by Geers and Moog. RESULTS Hearing performance was considerably improved after CI. In relation to the hearing performance at time T1, statistically significant threshold gains were observed in both groups in the T3 and T4 observation windows. At time T4, a threshold gain of 70 dB HL in the Case group and a gain of 84 dB HL in the Control group were observed. With speech therapy rehabilitation, a perception level of 6 was reached by 80.0% of patients in the Case group and by 100% of patients in the Control group. In terms of QoL, both groups showed improved post-CI scores. Statistical differences were observed between the 2 groups, with the Control group outperforming the Case group in all but the social section. CONCLUSIONS Despite age-related changes in auditory system and prolonged hearing deprivation, CIs offer audiological and QoL benefits in

  18. Intake of ruminant trans fatty acids in the Danish population aged 1-80 years

    DEFF Research Database (Denmark)

    Jakobsen, M. U.; Bysted, Anette; Andersen, N. L.;

    2006-01-01

    Objective: To estimate the intake of ruminant trans fatty acids (TFA) in the Danish population aged 1 - 80 years. Design: Descriptive study. Subjects: A sex- and age-stratified random sample drawn from the Danish Civil Registration System. A total of 3098 participants (51% female) aged 1 - 80 years...

  19. Evaluation of the results from arthroscopic surgical treatment of rotator cuff injuries in patients aged 65 years and over

    Directory of Open Access Journals (Sweden)

    Alberto Naoki Miyazaki

    2015-06-01

    Full Text Available OBJECTIVES: To evaluate the results from arthroscopic surgical treatment of rotator cuff injuries in patients aged 65 years and over.METHODS: Between 1998 and 2009, 168 patients underwent operations. Five cases were excluded. The remaining 163 patients were stratified according to their age group: 65-69 years (49.1%, 70-74 (26.4% and 75 years and over (24.5%. Their mean age was 71 years (range: 65-83. There were 63 male patients (38.7%. The mean length of time with pain, from the onset of symptoms to the surgery, was 23 months (range: 2 days to 240 months. Sixty-two patients (38% reported histories of trauma and 26 (16% reported that their pain worsened through exertion.RESULTS: From the UCLA criteria, 80.4% of the results were excellent, 16% good, 1.8% fair and 1.8% poor. Complications occurred in 11%. The final clinical result did not show any correlation with age progression, injury size or tendons affected. However, there was a significant association (p < 0.001 between the presence of trauma and larger injuries. The length of time between the onset of symptoms and the surgical procedure had a significant relationship (p < 0.027 with the postoperative results: the longer this time was, the worse the results were.CONCLUSION: Arthroscopic treatment of rotator cuff injuries in patients aged 65 years and over presented excellent and good results in 96.4% of the cases, according to the UCLA assessment, with a low complication rate. Advanced age did not show any influence on the postoperative clinical evolution, but the earlier the surgical treatment was instituted, the better the results were.

  20. Explanatory style and its functional relationship to job satisfaction for employed women age forty and over.

    Science.gov (United States)

    Phelps, L H; Waskel, S A

    1994-06-01

    An assessment of the relationship between explanatory style and perceived general job satisfaction is presented for 135 employed women age 40 and over who were asked to complete the Attributional Style Questionnaire and the Minnesota Satisfaction Questionnaire. Although a forced-order multiple regression analysis did not yield a significant correlation between explanatory style and perceived general job satisfaction, several interesting factors emerged. PMID:8058876

  1. Corrosion behavior of extrusion, under-aged, peaked-aged and over-aged WE93 alloys in NaHSO3 solutions

    Institute of Scientific and Technical Information of China (English)

    蒋全通; 马鸣龙; 张奎; 李兴刚; 李永军; 石国梁; 袁家伟

    2014-01-01

    The corrosion behaviors of extrusion, under-aged, peaked-aged and over-aged WE93 alloys in NaHSO3 solutions were in-vestigated by optical microscopy (OM), scanning electron microscopy (SEM) and X-ray diffraction (XRD). The weight loss rates, corrosion morphologies and polarization curves were analyzed. The peak-aged specimen in NaHSO3 salt spray had the highest corro-sion rate of 0.9787 mg/cm2/d, while extrusion specimen led to the lowest of 0.2184 mg/cm2/d. The specimens could be arranged in decreasing order of corrosion rates:extrusionaged. Polarization curves also gave effective evaluation of corrosion rates in agreement. The NaHSO3 played a great role in the corrosion behaviors of WE93 alloys. The main reasons were that HSO3–developed a reaction:O2+2HSO3–+2e→2HSO42–→2H++2SO42–to generate H+, accelerating the process of corrosion re-action. SO42–stimulated corrosion and led to an autocatalytic type of reaction:Mg2++SO42–+7H2O→MgSO4–7H2O. XRD character-ized that Mg(OH)2 and MgSO4·7H2O were the main corrosion products.

  2. Bleeding-Avoidance Strategies and Outcomes in Patients ≥80 Years of Age With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention (from the NCDR CathPCI Registry)

    OpenAIRE

    Dodson, John A.; Wang, Yongfei; Chaudhry, Sarwat I.; Curtis, Jeptha P.

    2012-01-01

    The purpose of our study was to evaluate the use of bleeding-avoidance strategies (BAS) and risk-adjusted bleeding over time in patients ≥80 years of age undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction. We analyzed data from the CathPCI Registry from July 1, 2006 through June 30, 2009. Patients were included if they were ≥80 years old, presented with ST-segment elevation myocardial infarction, and underwent primary PCI. We evaluated t...

  3. Clinical outcomes of helical tomotherapy for super-elderly patients with localized and locally advanced prostate cancer. Comparison with patients under 80 years of age

    International Nuclear Information System (INIS)

    We investigated the clinical outcomes of helical tomotherapy in 23 patients aged80 years with localized and locally advanced prostate cancer and compared the results with data from 171 patients under 80 years. All patients received helical tomotherapy in our hospital between September 2009 and October 2012. The median follow-up periods were 35 months in the aged group and 34 months in the younger group. The median prescribed dose in helical tomotherapy was 78 Gy in 39 fractions (range, 72–78 Gy). The 3-year overall survival and biochemical relapse-free rates were 92% and 96% in the aged group and 99.4% and 97.3% in the younger group, respectively. There was no significant difference between the two groups in the biochemical relapse-free rates. The 3-year cumulative incidences of late Grade 2 or higher rectal toxicity and urinary toxicity were 13% and 4.8% in the aged group and 7.0% and 1.2% in the younger group, respectively. There was no significant difference between the aged group and the younger group in the cumulative incidence rates of rectal toxicity or urinary toxicity. No patients exhibited Grade 4 or higher toxicity, and all patients improved with conservative therapy. Helical tomotherapy in super-elderly patients with localized and locally advanced prostate cancer had good biochemical control rates without severe late toxicity. Definitive helical tomotherapy may be the treatment of choice for patients with localized and locally advanced prostate cancer, even in those older than 80 years of age. (author)

  4. Prostate cancer and consistency of reporting sexual histories in men over age 50.

    Science.gov (United States)

    Dennis, L K; Ritchie, J M; Resnick, M I

    2005-01-01

    We conducted an in-person interview to examine the reliability of reported sexual histories among men over age 50 y with and without prostate cancer. Marriage and cohabitation were used as memory cues to recall sexual activity. High correlations on test-retest for questions evaluating sexual histories suggest reliable answers for most factors, and specifically for age at first sexual activity, and lifetime number of sexual partners. Low correlations were seen for ill-defined and socially undesirable items. These data suggest that men consistently report most measures of sexual activity when using marriage and cohabitation as memory cues to recall sexual histories. PMID:15983628

  5. Enthalpy and entropy changes during physical ageing of 20% polystyrene–80% poly(α-methylstyrene) blend and the cooling rate effects

    Energy Technology Data Exchange (ETDEWEB)

    Righetti, M.C., E-mail: cristina.righetti@ipcf.cnr.it; Johari, G.P.

    2015-05-10

    Highlights: • Aging of polystyrene–poly(α-methylstyrene) blend studied by DSC. • Model-free thermodynamics used to analyse the temperature, time and cooling rate effects. • Aging kinetics differ from the α-relaxation dynamics. • Fictive temperature’s change interpreted in terms of aging kinetics. - Abstract: Certain compositions of polymer blends remain mixed in the glassy state, and demix on heating and may demix or otherwise change on physical aging. To investigate these effects, we studied the loss of enthalpy and entropy of a 20% polystyrene–80% poly(α-methylstyrene) blend: (i) after aging it for varying periods at a fixed temperature, (ii) after aging it for a fixed period at various temperatures and (iii) after vitrifying it at two different cooling rates prior to the physical aging. The results have been analysed by: (a) fitting the TNM model for a non-exponential, non-linear relaxation, and (b) by determining the enthalpy and entropy loss on aging. A single set of TNM model-fit parameters did not fit the data obtained for different cooling rates, and for the physically aged blend, and for some conditions a sub-T{sub g} feature known from previous studies of pure polymers appeared. The enthalpy and entropy on physical aging are found to decrease non-exponentially, but the exponent, β{sup age}, and the characteristic time, τ{sub a} (i.e., reciprocal of the rate constant of aging-kinetics), differ from the β{sup cal} and τ{sub 0} determined by fitting the TNM model to the data. This indicates that either τ{sub a} itself is time-dependent during the relaxation, and/or β{sup age} varies with the temperature. Since the characteristic time of the α-relaxation process and its non-exponential parameter refer to density and structure fluctuations in a state of fixed volume and energy, these two are neither expected to be the same as the characteristic time and the parameter observed for aging, nor are they found to be the same. We also discuss

  6. Enthalpy and entropy changes during physical ageing of 20% polystyrene–80% poly(α-methylstyrene) blend and the cooling rate effects

    International Nuclear Information System (INIS)

    Highlights: • Aging of polystyrene–poly(α-methylstyrene) blend studied by DSC. • Model-free thermodynamics used to analyse the temperature, time and cooling rate effects. • Aging kinetics differ from the α-relaxation dynamics. • Fictive temperature’s change interpreted in terms of aging kinetics. - Abstract: Certain compositions of polymer blends remain mixed in the glassy state, and demix on heating and may demix or otherwise change on physical aging. To investigate these effects, we studied the loss of enthalpy and entropy of a 20% polystyrene–80% poly(α-methylstyrene) blend: (i) after aging it for varying periods at a fixed temperature, (ii) after aging it for a fixed period at various temperatures and (iii) after vitrifying it at two different cooling rates prior to the physical aging. The results have been analysed by: (a) fitting the TNM model for a non-exponential, non-linear relaxation, and (b) by determining the enthalpy and entropy loss on aging. A single set of TNM model-fit parameters did not fit the data obtained for different cooling rates, and for the physically aged blend, and for some conditions a sub-Tg feature known from previous studies of pure polymers appeared. The enthalpy and entropy on physical aging are found to decrease non-exponentially, but the exponent, βage, and the characteristic time, τa (i.e., reciprocal of the rate constant of aging-kinetics), differ from the βcal and τ0 determined by fitting the TNM model to the data. This indicates that either τa itself is time-dependent during the relaxation, and/or βage varies with the temperature. Since the characteristic time of the α-relaxation process and its non-exponential parameter refer to density and structure fluctuations in a state of fixed volume and energy, these two are neither expected to be the same as the characteristic time and the parameter observed for aging, nor are they found to be the same. We also discuss the change in the fictive temperature for

  7. The social network index and its relation to later-life depression among the elderly aged80 years in Northern Thailand

    Directory of Open Access Journals (Sweden)

    Aung MN

    2016-08-01

    Full Text Available Myo Nyein Aung,1 Saiyud Moolphate,2 Thin Nyein Nyein Aung,3 Chitima Katonyoo,2 Songyos Khamchai,4 Pongsak Wannakrairot1 1Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; 2Department of Public Health, Chiang Mai Rajabhat University, Chiang Mai, Thailand; 3Department of Public Health, Juntendo University School of Medicine, Tokyo, Japan; 4Chiang Mai Provincial Health Office, Chiang Mai, Thailand Background: Having a diverse social network is considered to be beneficial to a person’s well-being. The significance, however, of social network diversity in the geriatric assessment of people aged80 years has not been adequately investigated within the Southeast Asian context. This study explored the social networks belonging to the elderly aged80 years and assessed the relation of social network and geriatric depression. Methods: This study was a community-based cross-sectional survey conducted in Chiang Mai Province, Northern Thailand. A representative sample of 435 community residents, aged80 years, were included in a multistage sample. The participants’ social network diversity was assessed by applying Cohen’s social network index (SNI. The geriatric depression scale and activities of daily living measures were carried out during home visits. Descriptive analyses revealed the distribution of SNI, while the relationship between the SNI and the geriatric depression scale was examined by ordinal logistic regression models controlling possible covariants such as age, sex, and educational attainment. Results: The median age of the sample was 83 years, with females comprising of 54.94% of the sample. The participants’ children, their neighbors, and members of Buddhist temples were reported as the most frequent contacts of the study participants. Among the 435 participants, 25% were at risk of social isolation due to having a “limited” social network group (SNI 0–3, whereas 37% had a “medium” social network

  8. Mechanical properties of bulk polydimethylsiloxane for microfluidics over a large range of frequencies and aging times

    Science.gov (United States)

    Placet, V.; Delobelle, P.

    2015-03-01

    The dynamic mechanical characterization of polydimethylsiloxane (PDMS) over a large range of frequencies (10-2 deformation microscopy, have been used. Although the three techniques work at different scales and at different frequencies all the results match the same master curve. As expected, the storage and the loss moduli greatly increase with the frequency. Moreover, these moduli moderately increase with the aging time tv depending on the curing temperature. A simple model which takes the frequency and the aging time into account, and which is based on the Havriliak-Negami model, has been presented and identified. Hence, values of the relaxed and instantaneous moduli at tv = 0 and tv = ∞ are proposed. Only the relaxed moduli depend on the curing conditions and moreover it has been shown that the tangent of the phase lag is independent of the aging time and thus of the curing process.

  9. 23 CFR Appendix C to Part 658 - Trucks Over 80,000 Pounds on the Interstate System and Trucks Over STAA Lengths on the National...

    Science.gov (United States)

    2010-04-01

    ... must be equipped at a minimum with emergency equipment including fire extinguisher, spare fuses, tire... minimum shall comply with Federal Motor Carrier Safety Regulations in 49 CFR part 393. In addition, any... Carrier Safety Regulations of the U.S. Department of Transportation and Title 28, Arizona Revised...

  10. Short and long term outcomes of primary angioplasty in patients aged 75 years and over

    Directory of Open Access Journals (Sweden)

    Turgay Işık

    2011-06-01

    Full Text Available The treatment of elderly patients with ST segment elevated myocardial infarction (STEMI remains controversial. This study aimed to investigate the effects of primary angioplasty in elderly patients on in-hospital and long term major adverse cardiac events (MACE.Materials and methods: From October 2003 to March 2008, we retrospectively enrolled 220 patients aged 75 years and over with STEMI who underwent primary angioplasty. Patients’ characteristics, in-hospital and long term events were recorded.Results: Male/Female ratio of patients was 129/91 and mean age was 78.7 ± 3.6 (range, 75-97 years, and 58.6% of male. Of these patients 29.2% were diabetics, 69.8% were hypertensive, 34.4% were smoker and 43.5% were anemic at admission. Anterior myocardial infarction was diagnosed in 52.3% of patients. Mean pain-balloon time was 222 ± 116 minutes. Eighty two (38.2% of these 220 patients had three-vessel disease and 12 (5.7% were diagnosed as cardiogenic shock. Procedural success was observed in 79.6% of patients. Heart failure was observed 27.7% in hospital and intra aortic pump was used in 14.5% of patients. There was no significant difference between age groups in long term major cardiac events and in hospital mortality. Diabetes, leukocyte count at admission and in hospital heart failure were independent predictors of short term MACE and low hemoglobin level at admission and peak CKMB levels were independent predictors of long term MACE.Conclusions: Primary angioplasty in patients aged 75 years and over seems to be associated with low procedural complication, high procedural success, improved short and long term survival.

  11. Pondering over Some Chinese And Western Poems about Old Age%Pondering over Some Chinese And Wwstern Poems about Old Age

    Institute of Scientific and Technical Information of China (English)

    夏宏忖; 吴春容

    2007-01-01

    Through a comparative appreciation of Chinese and Western poems about old age, the present article tends to present a general convey of the western and eastern poets' attitudes and feelings towards old age, which is an aspect of human culture. The main themes are almost the same: reminiscence (sweet or bitter), solitude,contentment, detachment, sorrow and sentiment. But the Western are more optimistic and admire youth, regard old age as a natural stage of life. The Chinese, more conservative and perfectionist, show much more respect to the old, and think more about the past unfulfilled.

  12. The social network index and its relation to later-life depression among the elderly aged80 years in Northern Thailand

    Science.gov (United States)

    Aung, Myo Nyein; Moolphate, Saiyud; Aung, Thin Nyein Nyein; Katonyoo, Chitima; Khamchai, Songyos; Wannakrairot, Pongsak

    2016-01-01

    Background Having a diverse social network is considered to be beneficial to a person’s well-being. The significance, however, of social network diversity in the geriatric assessment of people aged80 years has not been adequately investigated within the Southeast Asian context. This study explored the social networks belonging to the elderly aged80 years and assessed the relation of social network and geriatric depression. Methods This study was a community-based cross-sectional survey conducted in Chiang Mai Province, Northern Thailand. A representative sample of 435 community residents, aged80 years, were included in a multistage sample. The participants’ social network diversity was assessed by applying Cohen’s social network index (SNI). The geriatric depression scale and activities of daily living measures were carried out during home visits. Descriptive analyses revealed the distribution of SNI, while the relationship between the SNI and the geriatric depression scale was examined by ordinal logistic regression models controlling possible covariants such as age, sex, and educational attainment. Results The median age of the sample was 83 years, with females comprising of 54.94% of the sample. The participants’ children, their neighbors, and members of Buddhist temples were reported as the most frequent contacts of the study participants. Among the 435 participants, 25% were at risk of social isolation due to having a “limited” social network group (SNI 0–3), whereas 37% had a “medium” social network (SNI 4–5), and 38% had a “diverse” social network (SNI ≥6). The SNI was not different among the two sexes. Activities of daily living scores in the diverse social network group were significantly higher than those in the limited social network group. Multivariate ordinal logistic regression analysis models revealed a significant negative association between social network diversity and geriatric depression. Conclusion Regular

  13. Mechanical properties of bulk polydimethylsiloxane for microfluidics over a large range of frequencies and aging times

    International Nuclear Information System (INIS)

    The dynamic mechanical characterization of polydimethylsiloxane (PDMS) over a large range of frequencies (10−2 < f < 105 Hz) and long aging times at room temperature (4 h < tv < ∼60 000 h) has been presented. Three samples with different curing conditions have been studied and three different techniques, dynamic mechanical analysis at different temperatures, nano-indentation and scanning micro-deformation microscopy, have been used. Although the three techniques work at different scales and at different frequencies all the results match the same master curve. As expected, the storage and the loss moduli greatly increase with the frequency. Moreover, these moduli moderately increase with the aging time tv depending on the curing temperature. A simple model which takes the frequency and the aging time into account, and which is based on the Havriliak–Negami model, has been presented and identified. Hence, values of the relaxed and instantaneous moduli at tv = 0 and tv = ∞ are proposed. Only the relaxed moduli depend on the curing conditions and moreover it has been shown that the tangent of the phase lag is independent of the aging time and thus of the curing process. (paper)

  14. Neurological and functional outcomes of subdural hematoma evacuation in patients over 70 years of age

    Directory of Open Access Journals (Sweden)

    Patrick Mulligan

    2013-01-01

    Full Text Available Background: Subdural hematoma (SDH is a common disease entity treated by neurosurgical intervention. Although the incidence increases in the elderly population, there is a paucity of studies examining their surgical outcomes. Objectives: To determine the neurological and functional outcomes of patients over 70 years of age undergoing surgical decompression for subdural hematoma. Materials and Methods: We retrospectively reviewed data on 45 patients above 70 years who underwent craniotomy or burr holes for acute, chronic or mixed subdural hematomas. We analyzed both neurological and functional status before and after surgery. Results: Forty-five patients 70 years of age or older were treated in our department during the study period. There was a significant improvement in the neurological status of patients from admission to follow up as assessed using the Markwalder grading scale (1.98 vs. 1.39; P =0.005, yet no improvement in functional outcome was observed as assessed by Glasgow Outcome Score. Forty-one patients were admitted from home, however only 20 patients (44% were discharged home, 16 (36% discharged to nursing home or rehab, 6 (13% to hospice and 3 (7% died in the postoperative period. Neurological function improved in patients who were older, had a worse pre-operative neurological status, were on anticoagulation and had chronic or mixed acute and chronic hematoma. However, no improvement in functional status was observed. Conclusion: Surgical management of SDH in patients over 70 years of age provides significant improvement in neurological status, but does not change functional status.

  15. Pneumothorax and malignant mesothelioma in patients over the age of 40.

    OpenAIRE

    Sheard, J. D.; Taylor, W.; Soorae, A; Pearson, M G

    1991-01-01

    Five patients over the age of 40 with malignant mesothelioma of the pleura presented with a spontaneous pneumothorax in the course of five years. The diagnosis of malignant mesothelioma was not suspected at surgery but was made by histological examination of the pleurectomy specimens. During this time 91 pleurectomies for recurrent pneumothorax were performed, 45 in patients over the age of 40; malignant mesothelioma therefore accounted for 11% of spontaneous pneumothorax requiring pleurectom...

  16. Relating with God Contributes to Variance in Happiness, over that from Personality and Age

    Directory of Open Access Journals (Sweden)

    John Fisher

    2013-06-01

    Full Text Available A previous study on university students reported that personal, communal, and environmental spiritual well-being contributed to happiness over and above personality but that relating with God did not. In this study, happiness was assessed using a modified Oxford Happiness Inventory. Personality scores were obtained using forms of Eysenck’s Personality Questionnaire. Four domains of spiritual well-being were determined using Fisher’s Spiritual Well-Being Questionnaire. Relationship with God was reflected by the Transcendental domain of spiritual well-being in this instrument. Studies with 466 university students from Australia, Northern Ireland, and England, 494 people attending churches in Ballarat, and 1002 secondary school students in Victoria showed that relating with God accounts for variance on happiness, over and above personality, and age.

  17. Germ-line transmission of trisomy 21: Data from 80 families suggest an implication of grandmaternal age and a high frequency of female-specific trisomy rescue

    Directory of Open Access Journals (Sweden)

    Kovaleva Natalia V

    2010-03-01

    Full Text Available Abstract Background Trisomy of chromosome 21 (T21; Down syndrome, DS is the most common aneuploidy in live births. Though its etiology has been intensively studied for a half of century, there are surprisingly many problems awaiting their elucidation. Some of the open questions are related directly to germ line mosaicism for T21, other problems include the prevalence of males with non-mosaic trisomy over females (skewed sex ratio, SR, the genetic predisposition to non-disjunction, etc. Studies in families of gonadal mosaicism (GM carriers might help resolving some of these problems. Results 80 families of carriers of GM, in which the sex of the offspring had been specified, were identified in the literature and in logbooks of two local genetic units. Mothers in these families were relatively young: only 8% of mothers were 35 years old and older at the time of delivery of their first affected offspring while the proportion of grandmothers on the GM carrier's side aged 35 years old and older was significantly higher (39%. Postzygotic rescue of T21 due to error in the meiosis I had been proposed as a mechanism of parental GM formation in 78% of the families with known origin of the T21. For the other 22%, rescue of errors in the meiosis II or postzygotic mitotic non-disjunction was assumed. Mosaicism for T21 in successive generations was reported in at least 12 families. The proportion of mosaics among affected female offspring (14% is significantly higher compared to that among affected male offspring (0%. Male preponderance (SR = 1.5 is found in non mosaic liveborn offspring with either maternally- or paternally transmitted T21. Among unaffected offspring of male carriers of GM there is a notable excess of females (SR = 0.27. Conclusion Both direct (results of cytogenetic and molecular study of the origin of trisomic line and indirect (advanced grandmaternal age on the side of GM carrier evidences allow to assume that significant proportion of

  18. Confabulation in healthy aging is related to poor encoding and retrieval of over-learned information.

    Science.gov (United States)

    Attali, Eve; Dalla Barba, Gianfranco

    2013-01-01

    Normal aging is characterized by deficits that cross multiple cognitive domains including episodic memory and attention. Compared to young adults (YA), older adults (OA) not only show reduction in true memories, but also an increase in false memories. In this study we aim to elucidate how the production of confabulation is influenced by encoding and retrieval processes. We hypothesized that in OA, compared to YA, over-learned information interferes with the recall of specific, unique past episodes and this interference should be more prominent when a concurrent task perturbs the encoding of the episodes to be recalled. We tested this hypothesis using an experimental paradigm in which a group of OA and a group of YA had to recall three different types of story: a previously unknown story, a well-known fairy tale (Snow White), and a modified well-known fairy tale (Little Red Riding Hood is not eaten by the wolf), in three different experimental conditions: (1) free encoding and free retrieval; (2) Divided attention (DA) at encoding and free retrieval; and (3) free encoding and DA at retrieval. Results showed that OA produced significantly more confabulations than YA, particularly, in the recall of the modified fairy tale. Moreover, DA at encoding markedly increased the number of confabulations, whereas DA at retrieval had no effect on confabulation. Our findings reveal the implications of two phenomena in the production of confabulation in normal aging: the effect of poor encoding and the interference of strongly represented, over-learned information in episodic memory recall.

  19. DIETARY SOURCES OF VITAMIN D AND SEASONAL VARIATIONS OF 25 (OH) VITAMIN D SERUM LEVELS IN MEN OVER 45 YEARS OF AGE IN LATVIA

    OpenAIRE

    VOIKA OLGA; ZARIŅŠ ZIGURD; SITOVA ANASTASIA

    2015-01-01

    Introduction. Over 50% of population are found to suffer from vitamin D deficiency. Vitamin D deficiency in Europe, Northern Europe, especially in elderly people, was revealed by many epidemiological studies. Insufficient vitamin D intake was detected in the population of the North America and Eastern Europe, comprising only 50% of vitamin D daily recommended dose. Materials and methods. 134 males aged 45-80 were included in the research. None of the research participants were taking any vita...

  20. Nocturia and associated morbidity in a Danish population of men and women aged 60-80 years

    DEFF Research Database (Denmark)

    Bing, M.H.; Moller, L.A.; Jennum, P.;

    2008-01-01

    OBJECTIVE To evaluate the association between nocturia and medical diseases, medication, urinary incontinence (UI), recurrent cystitis, smoking, alcohol, parity, hysterectomy, pelvic organ prolapse surgery, UI surgery. and prostate surgery. SUBJECTS AND METHODS The previously validated questionna...

  1. [Metastatic non-small cell lung cancer: Systemic treatment of patients aged 70 and over].

    Science.gov (United States)

    Quoix, Elisabeth; Ducoloné, Alain; Mennecier, Bertrand; Fraisse, Philippe

    2011-04-01

    Patients aged 70 and over represent the third of the population of patients with lung cancer. There has been for a long time a certain nihilism regarding the treatment of elderly patients with advanced lung cancer as well from medical doctors but also from families and patients themselves with the false belief of an indolent course of the disease in elderly patients. As a result, clinical trials devoted to elderly patients were quite scarce until the end of the last decade. Nevertheless, an important trial was published in 1999 with the comparison of vinorelbine as a single agent versus best supportive care only in patients aged 70 and over with an advanced non-small cell lung cancer. The survival benefit with vinorelbine was important. Then two trials were published comparing monotherapy with either vinorelbine or gemcitabine to the doublet vinorelbine and gemcitabine without convincing results. As a consequence, the ASCO 2004 recommendations were to treat elderly patients with a monotherapy (gemcitabine or vinorelbine). Recently an IFCT trial was presented at the plenary session of the ASCO 2010. A carboplatin (every 4weeks)+weekly paclitaxel doublet was compared to a vinorelbine or gemcitabine (choice of the center). The survival benefit was of such magnitude that the paradigm of treatment of elderly patients PS 0-2 with advanced NSCLC should be modified in favor of the tested doublet. There should be a reappraisal of the geriatric indexes recommended by the oncogeriatricians regarding their exact prognostic or predictive role. PMID:21388776

  2. 分析80例老年肺结核的临床特点及老年肺结核预防方法%Clinical features and prevention methods of aged tuberculosis

    Institute of Scientific and Technical Information of China (English)

    李荣; 徐凌忠

    2015-01-01

    有关研究报道称,活动性肺结核的患病率与年龄呈正相关关系,50岁以上人群患肺结核的几率呈直线上升,75岁及以上是肺结核患病的高峰年龄段。可见,老年肺结核已经成为最为强劲的“杀手”之一。本文调查研究了80例老年肺结核患者的临床资料,阐述了老年肺结核的临床特点以及预防方法。%related reports say that active tuberculosis suffering rate is positively correlated with age. Incidence of tuberculosis for people over 50 climbs straightly, and age of 75 and above reach the peak of pulmonary tuberculosis. So, aged tuberculosis has become one of the most powerful killers. The article investigated clinical data of 80 aged patients with tuberculosis, and related clinical features and prevention methods of aged patients with tuberculosis.

  3. Evaluation of Relationship between Parity and Coronary Artery Diseases in Women with Age Over 50 Years

    Directory of Open Access Journals (Sweden)

    M. Gharakhani

    2006-04-01

    Full Text Available Introduction & Objective: The coronary artery disease (CAD is the second cause of mortality in women over 40. The risk factors of CAD in females include: age over 55, BP>140/90, smoking and hyperlipidemia. As plasma lipoprotein level changes significantly during pregnancy, low density lipoprotein reaches its peak approximately in the week 36 of pregnancy. Hypercholesterolemia induced by pregnancy may be atherogen. The purpose of this study was to evaluate the relationship between multi-parity and CAD. Material & Methods: In this case-control study 230 women over 50 y were studied in the Ekbatan Hospital, Hamadan in 2005. 115 subjects out of them were considered as case group, who were selected among admitted patients with CAD in the heart ward. Other 115 cases without CAD who were admitted in internal and surgery wards, with normal cardiovascular consultation were selected as control group. Patients with known risk factors such as hypertension, hyperlipidemia, diabetic, obesity, active and passive smoker, Type A personality and any record of hormone replacement therapy were excluded. The data were analyzed using the commercially available software package SPSS version 11. Student׳s t-test and χ2 were used for analysis and results were expressed as mean ± SD, and p<0.05 was considered as significant level.Results: Mean ages of the first parity in case and control groups were 16.092 and 16.32 y respectively that the difference was not statistically significant. Mean of parity in case and control groups was 7.53.1 and 5.91.9 respectively (P<0.001. The average of cholesterol, HDL and LDL in control group were 164.2, 102.6 and 34.5 mg/dl respectively, and in control they were 164.1, 105.4 and 40.5 mg/dl respectively. Conclusion: Exposure with repeated hyperlipidemia induced pregnancy may increase the risk of CAD particularly in women with more than 4 parity. Age of the first pregnancy was not observed as a risk factor of CAD.

  4. Dental caries, periodontal disease, and cardiac arrhythmias in community-dwelling older persons aged 80 and older: is there a link?

    DEFF Research Database (Denmark)

    Holm-Pedersen, Poul; Avlund, Kirsten; Morse, Douglas E;

    2005-01-01

    lesions had 2.8 times higher odds (95% confidence interval=1.1-7.0) of arrhythmia than persons without active coronal caries, but there was no greater risk for persons with three or more coronal caries lesions. There was no association between periodontal disease and arrhythmia. CONCLUSION: The findings......OBJECTIVES: To examine whether caries or periodontitis is associated with cardiac arrhythmias in community-dwelling people aged 80 and older. SETTING: Urban, community-based population in Stockholm, Sweden. DESIGN: Cross-sectional. PARTICIPANTS: Eligible persons were identified through...... by a physician or the Stockholm Inpatient Register. Active root caries, active coronal caries, and periodontitis were assessed using previously defined National Institute of Dental and Craniofacial Research diagnostic criteria. RESULTS: The primary finding of the multivariate logistic regression analysis...

  5. Oral health of individuals aged 3-80 years in Jönköping, Sweden during 40 years (1973-2013). II. Review of clinical and radiographic findings.

    Science.gov (United States)

    Norderyd, Ola; Koch, Göran; Papias, Apostolos; Köhler, Alkisti Anastassaki; Helkimo, Anna Nydell; Brahm, Carl-Otto; Lindmark, Ulrika; Lindfors, Ninita; Mattsson, Anna; Rolander, Bo; Ullbro, Christer; Gerdin, Elisabeth Wärnberg; Frisk, Fredrik

    2015-01-01

    The aim of this epidemiological study performed in 2013 was to analyze various clinical and radiographic data on oral health and compare the results to those of four cross-sectional studies carried out 1973-2003. In 1973, 1983, 1993, 2003, and 2013 random samples of 1,000; 1,104; 1,078; 987; and 1,010 individuals, respectively, were studied. The individuals were evenly distributed in the age groups 3, 5, 10, 15, 20, 30, 40, 50, 60, 70, and 80o years. Eighty-year-olds were not included in 1973. All subjects were inhabitants of the city of Jönköping, Sweden. The clinical and radiographic examination assessed edentulousness, removable dentures, implants, number of teeth, caries, restorations, oral hygiene, calculus, periodontal status, and endodontic treatment. The frequency of edentulous individuals aged 40-70 years was 16, 12, 8, 1, and 0.3% in 1973, 1983, 1993, 2003, and 2013, respectively. No complete denture weareryounger than 80-years old was found in 2013. During the 40-year period, the mean number of teeth in the age groups 30-80 years increased. In 2013, the 60-year-olds had nearly complete dentitions. Implants were found in all age groups from 30 years of age. The total number of individuals with implants was 36 in 2013. This was higher than earlier surveys, 4 in 1993, and 18 in 2003. The percentage of children and adults without caries and restorations increased during the 40-year period. It was found that the percentage of caries-free 3- and 5-year-olds were 79% and 69%, respectively, of the individuals in 2013. In the age groups 10-20 years, the percentage of caries-free individuals increased between 2003 and 2013. In 2013, 43% of the 15-year-olds were completely free from caries and restorations compared to 20% in 2003. In all age groups 5-60 years, DFS was lower in 2013 compared to the earlier examinations.There was no major change in DFS between 2003 and 2013 in the age groups 70 and 80 years. The most obvious change was the decrease in number of FS

  6. Oral health of individuals aged 3-80 years in Jönköping, Sweden during 40 years (1973-2013). II. Review of clinical and radiographic findings.

    Science.gov (United States)

    Norderyd, Ola; Koch, Göran; Papias, Apostolos; Köhler, Alkisti Anastassaki; Helkimo, Anna Nydell; Brahm, Carl-Otto; Lindmark, Ulrika; Lindfors, Ninita; Mattsson, Anna; Rolander, Bo; Ullbro, Christer; Gerdin, Elisabeth Wärnberg; Frisk, Fredrik

    2015-01-01

    The aim of this epidemiological study performed in 2013 was to analyze various clinical and radiographic data on oral health and compare the results to those of four cross-sectional studies carried out 1973-2003. In 1973, 1983, 1993, 2003, and 2013 random samples of 1,000; 1,104; 1,078; 987; and 1,010 individuals, respectively, were studied. The individuals were evenly distributed in the age groups 3, 5, 10, 15, 20, 30, 40, 50, 60, 70, and 80o years. Eighty-year-olds were not included in 1973. All subjects were inhabitants of the city of Jönköping, Sweden. The clinical and radiographic examination assessed edentulousness, removable dentures, implants, number of teeth, caries, restorations, oral hygiene, calculus, periodontal status, and endodontic treatment. The frequency of edentulous individuals aged 40-70 years was 16, 12, 8, 1, and 0.3% in 1973, 1983, 1993, 2003, and 2013, respectively. No complete denture weareryounger than 80-years old was found in 2013. During the 40-year period, the mean number of teeth in the age groups 30-80 years increased. In 2013, the 60-year-olds had nearly complete dentitions. Implants were found in all age groups from 30 years of age. The total number of individuals with implants was 36 in 2013. This was higher than earlier surveys, 4 in 1993, and 18 in 2003. The percentage of children and adults without caries and restorations increased during the 40-year period. It was found that the percentage of caries-free 3- and 5-year-olds were 79% and 69%, respectively, of the individuals in 2013. In the age groups 10-20 years, the percentage of caries-free individuals increased between 2003 and 2013. In 2013, 43% of the 15-year-olds were completely free from caries and restorations compared to 20% in 2003. In all age groups 5-60 years, DFS was lower in 2013 compared to the earlier examinations.There was no major change in DFS between 2003 and 2013 in the age groups 70 and 80 years. The most obvious change was the decrease in number of FS

  7. Modelling the chemically aged and mixed aerosols over the eastern central Atlantic Ocean – potential impacts

    Directory of Open Access Journals (Sweden)

    M. Astitha

    2010-07-01

    Full Text Available Detailed information on the chemical and physical properties of aerosols is important for assessing their role in air quality and climate. This work explores the origin and fate of continental aerosols transported over the Central Atlantic Ocean, in terms of chemical composition, number and size distribution, using chemistry-transport models, satellite data and in situ measurements. We focus on August 2005, a period with intense hurricane and tropical storm activity over the Atlantic Ocean. A mixture of anthropogenic (sulphates, nitrates, natural (desert dust, sea salt and chemically aged (sulphate and nitrate on dust aerosols is found entering the hurricane genesis region, most likely interacting with clouds in the area. Results from our modelling study suggest rather small amounts of accumulation mode desert dust, sea salt and chemically aged dust aerosols in this Atlantic Ocean region. Aerosols of smaller size (Aitken mode are more abundant in the area and in some occasions sulphates of anthropogenic origin and desert dust are of the same magnitude in terms of number concentrations. Typical aerosol number concentrations are derived for the vertical layers near shallow cloud formation regimes, indicating that the aerosol number concentration can reach several thousand particles per cubic centimetre. The vertical distribution of the aerosols shows that the desert dust particles are often transported near the top of the marine cloud layer as they enter into the region where deep convection is initiated. The anthropogenic sulphate aerosol can be transported within a thick layer and enter the cloud deck through multiple ways (from the top, the base of the cloud, and by entrainment. The sodium (sea salt related aerosol is mostly found below the cloud base. The results of this work may provide insights relevant for studies that consider aerosol influences on cloud processes and storm development in the Central Atlantic region.

  8. Chemically aged and mixed aerosols over the Central Atlantic Ocean – potential impacts

    Directory of Open Access Journals (Sweden)

    H. A. C. Denier van der Gon

    2010-02-01

    Full Text Available Detailed information on the chemical and physical properties of aerosols is important for assessing their role in air quality and climate. This work explores the origin and fate of continental aerosols transported over the Central Atlantic Ocean, in terms of chemical composition, number and size distribution, using chemistry-transport models, satellite data and in situ measurements. We focus on August 2005, a period with intense hurricane and tropical storm activity over the Atlantic Ocean. A mixture of anthropogenic (sulphates, nitrates, natural (desert dust, sea salt and chemically aged (sulphate and nitrate on dust aerosols is found entering the hurricane genesis region, most likely interacting with clouds in the area. Results from our modelling study suggest rather small amounts of accumulation mode desert dust, sea salt and chemically aged dust aerosols in this Atlantic Ocean region. Aerosols of smaller size (Aitken mode are more abundant in the area and in some occasions sulphates of anthropogenic origin and desert dust are of the same magnitude in terms of number concentrations. Typical aerosol number concentrations are derived for the vertical layers near shallow cloud formation regimes, designating that the aerosol number concentration can reach several thousand particles per cubic centimetre. The vertical distribution of the aerosols indicates that the desert dust particles are often transported near the top of the marine cloud layer as they enter into the region where deep convection is initiated. The anthropogenic sulphate aerosol can be transported within a thick layer and enter the cloud deck through multiple ways (from the top, the base of the cloud and entrainment. The sodium (sea salt related aerosol is mostly found below the cloud base. The results of this work may provide insights relevant for studies that consider aerosol influences on cloud processes and storm development in the Central Atlantic region.

  9. 80岁以上患者外科急腹症的诊治特点%Characteristics in elderly patients over 80 years old with acute abdomen

    Institute of Scientific and Technical Information of China (English)

    郑亚民; 曹锋; 刘强; 刘东斌; 王悦华; 刘家峰; 李非

    2011-01-01

    目的 分析≥80岁外科急腹症住院患者的诊治特点.方法 将2002年1月1日至2009年12月31日外科急腹症入院治疗的5426例患者按年龄分为≥80岁组和<80岁组.观察≥80岁急腹症患者人数、所占比例、病种分布、伴发疾病等特点;统计分析手术比率、治疗效果、病死率、住院时间和住院花费.结果我院8年来纳入患者5426例,≥80岁患者420例,数量和所占百分比总体呈逐年增加趋势.患者从症状发作到就诊时间差2 h至21 d不等.常伴发多种疾病,以呼吸和心血管系统疾病居多.≥80岁组与<80岁组比较,急诊手术率下降(48.09% 比 64.19%,P<0.01),病死率增加(3.33% 比 1.38%,P<0.01),住院时间延长[(16.76±11.49)d 比 (14.50±16.08)d,P<0.01)],人均住院花费增加[(23 733.11±30 571.75)元比(18 530.83±29 637.46)元,P<0.01)].结论 根据≥80岁患者的发病特点制定个体化诊治方案;在制定卫生经济学政策和医疗保险制度时,注意考虑年龄对住院患者病死率、住院时间和治疗费用的影响.%Objective To evaluate the characteristics of diagnosis and treatment in elderly patients over 80 years old with acute abdomen. Methods 5426 elderly patients with acute abdomen were enrolled from January 1,2002 to December 31, 2009 in our hospital and were divided into two groups according age: one group with patients ≥ 80 years old(420 cases) and another group < 80 years old( 5006 cases). Data were analyzed include operability rate, mortality, lenght of stay and admission fee. Results More and more aged patients were treated in hospital. They went to hospital in from 2 h to 21 d after unfitness. They often have several complications including respiratory, cardiovascular system diseases. Compared with < 80 group, operability rate was lower (48.09% vs 64. 19%, P < 0. 01 ), mortality was higher ( 3.33% vs 1.38% ,P <0. 01 ) ,mean hospital length of stay was longer ( 16.76 ± 11.49 d vs 14. 50

  10. Survival Analysis of Non-Small Cell Lung Cancer in Patients Aged 70 and over

    Directory of Open Access Journals (Sweden)

    Jiankun SUN

    2008-04-01

    Full Text Available Background and Objective With a trend of worldwide increasing incidence of elderly population, more and more people pay close attention to diseases in the elderly. Lung cancer is a typical disease of the elderly patients. Around one-third of all patients with non-small cell lung cancer (NSCLC are over the age of 70. Many authors use the age 70 to define the elderly patients in lung cancer. The objective of this study is to evaluate the survival of patients older than 70 with NSCLC and explore the independent prognostic factors in this group of patients. Methods 148 elderly patients with NSCLC were reviewed. All the potential prognostic factors, including sex, age, smoke, symptoms, pathological types, clinical stage, ECOG performance status, complication, focus resection, radiotherapy and chemotherapy were analyzed by COX regression in SPSS 13.0 software. Results After 5-168 months follow-up, 119 patients died, the overall survival rate was 19.6%. 1,2,3,5-year survival rates were 43.2%, 19.0%, 9.0% and 5.4% respectively. Median survival time (MST was 9.29 moths. COX regression showed clinical stage (P=0.002, ECOG performance status (P=0.000, focus resection (P=0.012 and radiotherapy of primary site (P=0.012 were the independent prognostic factors. Conclusion The elderly patients with NSCLC in early stage and good performance status tend to have longer life expectance, whereas resection and radiotherapy of primary site can prolong the survival time (P<0.05.

  11. Comparison of single-agent chemotherapy and targeted therapy to first-line treatment in patients aged 80 years and older with advanced non-small-cell lung cancer

    Directory of Open Access Journals (Sweden)

    Zhang QQ

    2015-04-01

    Full Text Available Qianqian Zhang,1 Zhehai Wang,2 Jun Guo,2 Liyan Liu,2 Xiao Han,2 Minmin Li,1 Shu Fang,1 Xiang Bi,1 Ning Tang,1 Yang Liu1 1School of Medicine and Life Sciences, Shandong Academy of Medical Sciences, University of Jinan, 2Department of Oncology, Shandong Cancer Hospital, Jinan, People’s Republic of China Purpose: The aim of this study was to compare single-agent chemotherapy with targeted therapy in initial treatment and to explore a better choice of treatment for patients aged 80 years and older with advanced non-small-cell lung cancer (NSCLC.Patients and methods: A retrospective chart review was conducted for 136 patients aged 80 years and older who were cytopathologically diagnosed and staged as advanced (stage IIIB or IV NSCLC. The patient population was divided into two treatment groups: 78 patients were allocated to the chemotherapy group (group A, pemetrexed or gemcitabine or docetaxel as a single agent, and 60 patients were allocated to another group and received epidermal growth factor-receptor tyrosine-kinase inhibitors (group B, erlotinib or gefitinib as a single agent. The primary end points were overall survival (OS and progression-free survival (PFS, and the secondary end points were response rate, disease-control rate, safety, and quality of life.Results: In group A and group B, respectively, the median PFS was 2 versus 4 months (P=0.013, and the median OS was 8 versus 16 months (P=0.025. The 1- and 2-year survival rates of the two groups were 23.7% (group A, 18 of 76 versus 76.7% (group B, 46 of 60 and 13.2% (group A, ten of 76 versus 10% (group B, six of 60, respectively. The response rate and disease-control rate were 28.9% versus 36.7% (P=0.39 and 57.9% versus 76.7% (P=0.022 in group A and group B, respectively.Conclusion: Elders aged 80 years and over with advanced NSCLC in group B had longer PFS and OS compared with group A. It was well tolerated in group B because of the mild adverse effects. Targeted therapy can be

  12. Epilepsy with onset at over 50 years of age: clinical and electroencephalographic characteristics

    Directory of Open Access Journals (Sweden)

    Glória Maria Almeida Souza Tedrus

    2012-10-01

    Full Text Available Epilepsy in older individuals has an elevated incidence. The objective of the present work was to evaluate the clinical, EEG and brain imaging aspects in patients showing late-onset epilepsy. Fifty-five patients with late-onset epilepsy (older than 50 years were evaluated. They were composed of two groups according to the onset age of the epilepsy seizure (ES: 51-60 (G51-60 and over 60 (G60+ years. Focal ES predominated although they were less frequent in G60+. The occurrence of status epilepticus was high and more frequent in G60+ whereas seizures in series predominated in G51-60. Symptomatic epilepsy was more frequent and the vascular etiology predominated. Epileptiform activity was associated with a greater number of ES, and background activity abnormalities were more frequent in G60+. In conclusion, epilepsy with onset at over 50 was predominantly focal and symptomatic, with a high occurrence of status epilepticus and of seizures in series.

  13. Spectroscopic Confirmation of the Rich z=1.80 Galaxy Cluster JKCS 041 Using the WFC3 Grism: Environmental Trends in the Ages and Structure of Quiescent Galaxies

    CERN Document Server

    Newman, Andrew B; Andreon, Stefano; Treu, Tommaso; Raichoor, Anand; Trinchieri, Ginevra

    2013-01-01

    We present HST/WFC3 imaging and grism spectroscopy of the distant galaxy cluster JKCS041. Our survey yields 98 redshifts whose precision is typically ~20x better than photometric estimates. We confirm that JKCS041 is a rich cluster and derive a redshift z=1.80 via the identification of 19 member galaxies, of which 15 are quiescent. These members are spatially aligned with diffuse X-ray emission seen by Chandra. As JKCS041 is the most distant known cluster with such a large and spectroscopically-confirmed quiescent population, it provides an unique opportunity to study the effect of the environment on galaxy properties at early epochs. We construct composite spectra of the quiescent members that clearly reveal Balmer and metallic absorption lines. From these, we infer that the more massive members (log M*>11) have a mean stellar age of 1.4+0.3-0.2 Gyr, whereas lower-mass examples (log M*=10.5-11) have a younger mean age of 0.9+0.2-0.1 Gyr. These ages agree closely with those inferred by Whitaker et al. for sim...

  14. Obstructive sleep apnea in a Danish population of men and women aged 60-80 years with nocturia

    DEFF Research Database (Denmark)

    Bing, Mette Hornum; Jennum, Poul; Moller, Lars Alling;

    2012-01-01

    The aim of the present study was in a case-control design to evaluate the association between nocturia and obstructive sleep apnea, in men and women who had nocturia ≥ 2 per night (nocturics) compared to those without nocturia (controls)....

  15. Predictors of five-year functional ability in a longitudinal survey of men and women aged 75 to 80. The 1914-population in Glostrup, Denmark

    DEFF Research Database (Denmark)

    Schroll, M; Avlund, K; Davidsen, M

    1997-01-01

    -based, representative sample, the objectives were: to describe five-year outcome regarding death and functional ability to age 75 to 80, as well as individual changes in muscle strength, physical performance in simple function tests and self-reported physical activity, and relate "risk markers" to five-year outcome...... in mobility functions. "Stability" in mobility functions was related to ability to mount stairs, walking speed, mood and physical activity. Number of chronic diseases and low pulmonary function were only related to mobility in men. Among people who improved their function, many had rather low baseline......-values, suggesting regression to the mean. Multiple logistic regression was conducted. The follow-up survey found that female participants were more physically active at baseline than non-participants. Five-year mortality was independently related to physical activity (RR = 0.41), pulmonary function in men (RR = 0...

  16. The HIV Care Cascade Measured Over Time and by Age, Sex, and Race in a Large National Integrated Care System.

    Science.gov (United States)

    Horberg, Michael Alan; Hurley, Leo Bartemeier; Klein, Daniel Benjamin; Towner, William James; Kadlecik, Peter; Antoniskis, Diana; Mogyoros, Miguel; Brachman, Philip Sigmund; Remmers, Carol Louise; Gambatese, Rebecca Claire; Blank, Jackie; Ellis, Courtney Georgiana; Silverberg, Michael Jonah

    2015-11-01

    HIV care cascades can evaluate programmatic success over time. However, methodologies for estimating cascade stages vary, and few have evaluated differences by demographic subgroups. We examined cascade performance over time and by age, sex, and race/ethnicity in Kaiser Permanente, providing HIV care in eight US states and Washington, DC. We created cascades for HIV+ members' age ≥13 for 2010-2012. We measured "linkage" (a visit/CD4 within 90 days of being diagnosed for new patients; ≥1 medical visit/year if established); "retention" (≥2 medical visits ≥60 days apart); filled ART (filled ≥3 months of combination ART); and viral suppression (HIV RNA age, and race/ethnicity. We found men had statistically (p age was associated (p care results improved over time, but significant differences exist by patient demographics. Specifically, retention efforts should be targeted toward younger patients and blacks; women, blacks, and Latinos require greater ART prescribing.

  17. Determinants of locomotor disability in people aged 55 years and over: The Rotterdam study

    International Nuclear Information System (INIS)

    Locomotor disability, as defined by difficulties in activities of daily living related to lower limb function, can be the consequence of diseases and impairments of the cardiovascular, pulmonary, nervous, sensory and musculoskeletal system. We estimated the associations between specific diseases and impairments and locomotor disability, and the proportion of disability attributable to each condition, controlling for age and comorbidity. The Rotterdam Study is a prospective follow-up study among people aged 55 years and over in the general population. Locomotor disability in 1219 men and 1856 women was assessed with the Stanford Health Assessment Questionnaire. Diseases and impairments were radiological osteoarthritis, pain of the hips and knees, morning stiffness, fractures, hypertension, vascular disease, ischemic heart disease, stroke, heart failure, chronic obstructive pulmonary disease (COPD), depression, Parkinson's disease, osteoporosis, diabetes mellitus, overweight, and low vision. Adjusted odds ratios, etiologic and attributable fractions were calculated for locomotor disability. The occurrence of locomotor disability can partly be ascribed to joint pain, COPD, morning stiffness, diabetes and heart failure in both men and women. In addition in women osteoarthritis, osteoporosis, low vision, fractures, stroke and Parkinson's disease are significant etiologic fractions. In men with morning stiffness, joint pain, heart failure, diabetes mellitus, and COPD a significant proportion of their disability is attributable to this impairment. In women this was the case for Parkinson's disease, morning stiffness, low vision, heart failure, joint pain, diabetes, radiological osteoarthritis, stroke, COPD, osteoporosis, and fractures of the lower limbs, in that order. We conclude that locomotor complaints, heart failure, COPD and diabetes mellitus contribute considerably to locomotor disability in non-institutionalized elderly people

  18. The validation of a French-language version of the Aging Perceptions Questionnaire (APQ) and its extension to a population aged 55 and over

    LENUS (Irish Health Repository)

    Ingrand, Isabelle

    2012-04-30

    AbstractBackgroundSeveral studies have shown the influence of the perceptions of aging on the cognitive functioning and the mental and physical health of older people. These relationships have not to date been studied in France where validated instruments are lacking. The primary objective of this study was to validate a French-language version of the Aging Perceptions Questionnaire (APQ) in the French general population aged 65 and over. The secondary objective was to study the stability of the dimensions of this instrument among participants aged 55 to 64.MethodsThe study was proposed to the cohort of the Observatoire Régional du Vieillissement (OPREVI) (observatory of aging), located in a small town in Poitou-Charentes (western France). An anonymous questionnaire including the APQ was sent by mail to inhabitants aged 55 and over. The original English language APQ was described with adults aged 65 and older. It has 32 items distributed on 7 dimensions: timeline chronic and cyclical, positive and negative consequences, positive and negative control and emotional representations.Results656 adults participated in this survey (286 men, 370 women). Among those aged 65 and over (n = 394), the seven-factor structure estimated by confirmatory factor analysis was coherent with original findings. Internal consistency as evaluated by Cronbach alpha, was between 0.83 for consequences negative and 0.52 for control negative. Several dimensions were strongly correlated. Among participants aged 55 to 64 (n = 262), the same factorial model yielded an acceptable fit. Multi-group confirmatory factor analysis concluded to approximate factorial invariance between the two age groups with a null delta in comparative fit index.ConclusionThis study among French people aged 65 and over, added further evidence of the multidimensional structure of the French version of the APQ which is superimposed to the dimensions of the original Irish version. The same factorial structure

  19. The validation of a French-language version of the Aging Perceptions Questionnaire (APQ and its extension to a population aged 55 and over

    Directory of Open Access Journals (Sweden)

    Ingrand Isabelle

    2012-04-01

    Full Text Available Abstract Background Several studies have shown the influence of the perceptions of aging on the cognitive functioning and the mental and physical health of older people. These relationships have not to date been studied in France where validated instruments are lacking. The primary objective of this study was to validate a French-language version of the Aging Perceptions Questionnaire (APQ in the French general population aged 65 and over. The secondary objective was to study the stability of the dimensions of this instrument among participants aged 55 to 64. Methods The study was proposed to the cohort of the Observatoire Régional du Vieillissement (OPREVI (observatory of aging, located in a small town in Poitou-Charentes (western France. An anonymous questionnaire including the APQ was sent by mail to inhabitants aged 55 and over. The original English language APQ was described with adults aged 65 and older. It has 32 items distributed on 7 dimensions: timeline chronic and cyclical, positive and negative consequences, positive and negative control and emotional representations. Results 656 adults participated in this survey (286 men, 370 women. Among those aged 65 and over (n = 394, the seven-factor structure estimated by confirmatory factor analysis was coherent with original findings. Internal consistency as evaluated by Cronbach alpha, was between 0.83 for consequences negative and 0.52 for control negative. Several dimensions were strongly correlated. Among participants aged 55 to 64 (n = 262, the same factorial model yielded an acceptable fit. Multi-group confirmatory factor analysis concluded to approximate factorial invariance between the two age groups with a null delta in comparative fit index. Conclusion This study among French people aged 65 and over, added further evidence of the multidimensional structure of the French version of the APQ which is superimposed to the dimensions of the original Irish version. The same

  20. 320 Gb/s Single polarization OTDM Transmission over 80 km Standard Transmission Fiber

    DEFF Research Database (Denmark)

    Siahlo, Andrei; Seoane, Jorge; Clausen, Anders;

    2005-01-01

    Optical time-division multiplexing (OTDM) is an attractive technique for increasing the capacity of optical transmission systems. 320 Gbit/s single-channel and single-polarization error-free transmission over continuous spans of either 80 km SMF or 77 km NZDSF are realized.......Optical time-division multiplexing (OTDM) is an attractive technique for increasing the capacity of optical transmission systems. 320 Gbit/s single-channel and single-polarization error-free transmission over continuous spans of either 80 km SMF or 77 km NZDSF are realized....

  1. Chemical fingerprint and impact of shipping emissions over a western Mediterranean metropolis: Primary and aged contributions

    International Nuclear Information System (INIS)

    An intensive monitoring campaign was carried out in the harbor of Barcelona (Spain) to quantify the contribution of primary shipping emissions (PSE) on PM10. Chemical composition of inorganic species, as well as OC and EC, was completed, and a source apportionment analysis by Positive Matrix Factorization was conducted. Among the 6 sources extracted, two were linked to harbor emissions: dusty materials released in different areas along the harbor and fuel–oil combustion. On average, harbor emissions accounted for 31% of the PM10 mass. Since the chemical signature of PSE was not determined neither their contribution was obtained, additional approaches were followed and mainly consisted in: 1) the evaluation of V/Ni and V/Cu ratios to identify those days affected by PSE; 2) the identification of the chemical components increasing under the influence of PSE; 3) the calculation of the daily and average PSE from their experimentally-determined chemical signature and the experimental concentrations of vanadium. As a result, the contribution of PSE was estimated in 0.84 μg m−3 (2.7% of PM10) and the residual fuel–oil combustion factor (3.6 μg m−3, 12% of PM10) was interpreted as aged shipping emissions. The present study splits the contribution of shipping emissions into primary and aged, and highlights the importance of atmospheric mixing and aging processes in western Mediterranean atmospheres. In the case of shipping emissions, the aged products were found to be dominant with respect to the primary ones even in the vicinity of the source. Highlights: • Primary and aged shipping emissions were quantified. • An experimental chemical profile for primary shipping emissions is provided. • Aged shipping emissions prevailed even in the proximity of the emission source

  2. Chemical fingerprint and impact of shipping emissions over a western Mediterranean metropolis: Primary and aged contributions

    Energy Technology Data Exchange (ETDEWEB)

    Pey, Jorge, E-mail: jorge.pey@univ-amu.fr [Institute of Environmental Assessment and Water Research, IDÆA-CSIC, 08034 Barcelona (Spain); Aix-Marseille Université, CNRS, LCE FRE 3416, 13331 Marseille (France); Department of Epidemiology, Lazio Region, 00198 Roma (Italy); Pérez, Noemí [Institute of Environmental Assessment and Water Research, IDÆA-CSIC, 08034 Barcelona (Spain); Department of Epidemiology, Lazio Region, 00198 Roma (Italy); Cortés, Joaquim [Autoriat Portuaria de Barcelona, 08002 Barcelona (Spain); Alastuey, Andrés; Querol, Xavier [Institute of Environmental Assessment and Water Research, IDÆA-CSIC, 08034 Barcelona (Spain)

    2013-10-01

    An intensive monitoring campaign was carried out in the harbor of Barcelona (Spain) to quantify the contribution of primary shipping emissions (PSE) on PM{sub 10}. Chemical composition of inorganic species, as well as OC and EC, was completed, and a source apportionment analysis by Positive Matrix Factorization was conducted. Among the 6 sources extracted, two were linked to harbor emissions: dusty materials released in different areas along the harbor and fuel–oil combustion. On average, harbor emissions accounted for 31% of the PM{sub 10} mass. Since the chemical signature of PSE was not determined neither their contribution was obtained, additional approaches were followed and mainly consisted in: 1) the evaluation of V/Ni and V/Cu ratios to identify those days affected by PSE; 2) the identification of the chemical components increasing under the influence of PSE; 3) the calculation of the daily and average PSE from their experimentally-determined chemical signature and the experimental concentrations of vanadium. As a result, the contribution of PSE was estimated in 0.84 μg m{sup −3} (2.7% of PM{sub 10}) and the residual fuel–oil combustion factor (3.6 μg m{sup −3}, 12% of PM{sub 10}) was interpreted as aged shipping emissions. The present study splits the contribution of shipping emissions into primary and aged, and highlights the importance of atmospheric mixing and aging processes in western Mediterranean atmospheres. In the case of shipping emissions, the aged products were found to be dominant with respect to the primary ones even in the vicinity of the source. Highlights: • Primary and aged shipping emissions were quantified. • An experimental chemical profile for primary shipping emissions is provided. • Aged shipping emissions prevailed even in the proximity of the emission source.

  3. Smoking, Antioxidant Supplementation and Dietary Intakes among Older Adults with Age-Related Macular Degeneration over 10 Years

    OpenAIRE

    Gopinath, Bamini; Flood, Victoria M; Kifley, Annette; Liew, Gerald; Mitchell, Paul

    2015-01-01

    We aimed to compare the micronutrient usage and other lifestyle behaviors over 10 years among those with and without age-related macular degeneration (AMD). 1612 participants aged 49+ years at baseline were re-examined over 10 years, west of Sydney, Australia. AMD was assessed from retinal photographs. Dietary data were collected using a semi-quantitative food frequency questionnaire. Smoking status was self-reported. 56 participants had any AMD at baseline, of these 25% quit smoking at 5 yea...

  4. Giant Angiokeratoma of Fordyce over the Vulva in a Middle-Aged Woman: Case Report and Review of Literature

    OpenAIRE

    Kudur, Mohan H; Manjunath Hulmani

    2013-01-01

    Angiokeratoma of Fordyce occurring over vulva is rare. Angiokeratoma of Fordyce commonly occurs in males over scrotum or penile shaft and presents as multiple verrucous reddish papules. They are usually asymptomatic and noticed accidentally. In the present article, we present and review the literature of giant angiokeratoma of Fordyce in middle-aged women due to its rarity.

  5. Socioeconomic Status and Obesity Gradient over Age:New Evidence from China.

    OpenAIRE

    Bing Ma

    2010-01-01

    This paper presents a systematic analysis of the impact of socioeconomic status (SES) on overweight and obesity in China and investigates how and why the SES-obesity gradient differs with age. Using a longitudinal sample drawn from the China Health and Nutrition Survey (CHNS), I find that body mass index (BMI) is positively associated with SES during early childhood but becomes inversely related to childhood SES as children age into adulthood. Estimation results show that children from low SE...

  6. Nutrition through the life span. Part 3: adults aged 65 years and over.

    Science.gov (United States)

    Shepherd, Alison

    The UK has an ageing population, but this is not being matched by a similar increase in healthy life expectancy. The greatest challenge in the 21st century will be to improve the quality of life as ageing occurs. Health is the most important prerequisite for people to enjoy life in their older years (Brundtland, 1988). Diet is one factor that is believed to play a key role in the prevention and treatment of chronic diseases associated with ageing. The third and final part of this series addressing the concept of nutrition through the lifespan seeks to educate health-care professionals as to what constitutes a healthy diet for the elderly population, and gives practical guidance as to how to try and prevent the ever-growing problem of malnutrition within this age group. It is suggested that when the older adult is hospitalized their risk of malnutrition increases. Therefore, some guidance for the use of oral nutritional supplements in this population is given. Good nutrition and physical exercise are essential for healthy ageing from both a physical and psychological perspective (NICE, 2008). Therefore a multidisciplinary life course approach to ageing is vital to minimizing its complications for quality of life and subsequent public health (Denny, 2008). PMID:19273990

  7. 80岁以上高龄老年骨质疏松症的规范诊治和注意事项%Standard diagnosis and treatment and attentions in elder osteoporosis patients of 80-year and over

    Institute of Scientific and Technical Information of China (English)

    边平达; 陈锦平

    2015-01-01

    Osteoporosis ( OP) is a disease characterized by low bone mass and microarchitectural deterioration of the bone tissue, which leads to increased bone fragility and consequent risk of bone fractures.In the recent years, along with the population ageing in the society, the number of OP in the elderly is getting more and more.The mechanism of OP in the elderly is associated with low sex hormone level, poor nutritional status, lack of motility, some diseases, etc.Elder OP patients are easy to suffer frangible fractures, which lead to high rate of disability and death.The basic content of diagnosis and treatment on OP in the elderly includes general investigation and health education, appropriate anti-osteoporosis drug selection, and proper therapeutic strategy.The detection of bone turnover markers ( BTMs) serves as a basis for selecting anti-osteoporosis drugs.In general, elder osteopenia patients with high BTMs need to choose antiresorptive drugs, such as bisphosphonates and selective estrogen receptor modulators ( SERMs) .Those whose BTMs are lower need to take bone anabolic drugs such as the 1-34 fragment of recombinant human parathyroid hormone ( teriparatide) .It is necessary for elder OP patients to adjust therapeutic plan on the basis of bone mineral density and BTMs variation, and to avoid long-term use of bisphosphonates.%骨质疏松症( OP)是一种以骨量低下、骨微结构破坏,导致骨脆性增加、易发生骨折为特征的全身性疾病。近年来,随着人口老龄化社会的到来,高龄老年OP患者越来越多。高龄老年OP的发生与高龄老人体内性激素(包括雌激素和雄激素)水平下降、营养物质摄入减少、活动量下降、某些疾病等因素有关。高龄老年OP患者不仅脆性骨折的发生率高,而且骨折后容易致残、致死。高龄老年OP诊治的基本内容包括普查和健康教育、选择合适的抗OP药物、及时调整治疗方案等。骨转换标志物( BTMs

  8. Over 80% Lead Battery Enterprises Closed Down or Suspended Operation

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    <正>It is reported that by July 31st,a total of 1930 enterprises engaged in the production,assembly and recycling (secondary lead) of lead battery products across the nation have received investigation.Wherein,583 were outlawed and closed down,405 were suspended for rectifica

  9. AIDS in adults 50 years of age and over: characteristics, trends and spatial distribution of the risk

    Directory of Open Access Journals (Sweden)

    Jordana de Almeida Nogueira

    2014-06-01

    Full Text Available OBJECTIVE: to analyze the sociodemographic characteristics, epidemic trend and spatial distribution of the risk of AIDS in adults 50 years of age and over.METHOD: population-based, ecological study, that used secondary data from the Notifiable Disease Information System (Sinan/AIDS of Paraíba state from the period January 2000 to December 2010.RESULTS: during the study period, 307 cases of AIDS were reported among people 50 years of age or over. There was a predominance of males (205/66, 8%, mixed race, and low education levels. The municipalities with populations above 100 thousand inhabitants reported 58.5% of the cases. There was a progressive increase in cases among women; an increasing trend in the incidence (positive linear correlation; and an advance in the geographical spread of the disease, with expansion to the coastal region and to the interior of the state, reaching municipalities with populations below 30 thousand inhabitants. In some locations the risk of disease was 100 times greater than the relative risk for the state.CONCLUSION: aging, with the feminization and interiorization of the epidemic in adults 50 years of age and over, confirms the need for the induction of affirmative policies targeted toward this age group.

  10. Central Tropical Pacific SST and Salinity Variability over the Little Ice Age

    Science.gov (United States)

    Sayani, H. R.; Cobb, K. M.; Khare, A.; Stone, C.; Grothe, P. R.; Chen, T.; Cheng, H.; Lu, Y.; Edwards, R. L.

    2015-12-01

    Anthropogenic trends are difficult to separate from natural variability in the tropical Pacific, where instrumental data coverage is sparse. Of particular interest are variations of climate in the pre-industrial era, but instrumental data from this time period is virtually nonexistent. Corals allow for the investigation of pre-industrial climate variability, but most living coral colonies rarely span more than a century. Fossil corals provide a valuable archive of climate variability over the past millennia [Cobb et al., 2013] and are best suited to the reconstruction of ENSO. For the reconstruction of mean climate, systematic offsets between proxy records from contemporaneous corals translates to large error bars on the resulting reconstructions [e.g. Felis et al., 2003; Pfeiffer et al., 2009]. By building composite paleoclimate records using multiple corals from the Line Islands (2°N - 6°N, 157°W - 162°W), we quantify mean climate state and climate variability in the central tropical Pacific (CTP) during the Little Ice Age (LIA). We compare paired d18O and Sr/Ca records from Line Island fossil corals to a large collection of modern coral d18O and Sr/Ca records from the same islands to estimate SST and salinity changes from the LIA to the late 20th century. Taken together, Sr/Ca records from three Palmyra Atoll fossil corals spanning 1630-1703CE suggest CTP temperatures may have been 1.7±0.9˚C cooler during much of the 17th century. Reconstructed seawater d18O values are indicative of drier conditions at Palmyra, consistent with a southward shift of the ITCZ during the LIA documented in sediments from the Line Islands [Sachs et al., 2009]. We compare the results from seven LIA-dated fossil corals from nearby Christmas Island (Kiritimati; 2˚N, 157˚W) to the results obtained from Palmyra, enabling us to resolve potential shifts in the meridional gradients of SST and hydrology in this region during the LIA. References:Cobb, K. M., et al. (2013) Science. doi

  11. [Risk factors of serious bleeding among ambulatory patients taking antivitamin K aged 75 and over].

    Science.gov (United States)

    Blas-Châtelain, C; Chauvelier, S; Foti, P; Debure, C; Hanon, O

    2014-05-01

    The benefits of anti-vitamin K (AVK) drugs have been acknowledged in several indications. Such indications increasing with increasing age, AVK prescriptions also increases with age. At the same time, conditions involving significant bleeding are common in this elderly population. It is thus essential to recognize the determining factors. This study included all patients taking AVK drugs aged 75 years and older who sought emergency care at the Cochin Hospital from January to December 2011 for significant bleeding. These patients were compared with a cohort of patients aged 75 years or older who were taking AVK drugs and who were admitted to the same unit during the same time period for other reasons. The case-control comparison included demographic data, comorbidity factors, multiple medications, emergency measured INR, and CHA2DS2VASC level. The hemorrhagic risk was evaluated by HEMORR2HAGES and HAS-BLED. A total of 34 patients were studied and compared with 70 case-controls. The Charlson comorbidity index was higher in patients than case-controls (PAVK drugs is related to their higher comorbidity and hemorrhagic levels which need to be evaluated before starting or stopping AVK treatment.

  12. Language and Ageing--Exploring Propositional Density in Written Language--Stability over Time

    Science.gov (United States)

    Spencer, Elizabeth; Craig, Hugh; Ferguson, Alison; Colyvas, Kim

    2012-01-01

    This study investigated the stability of propositional density (PD) in written texts, as this aspect of language shows promise as an indicator and as a predictor of language decline with ageing. This descriptive longitudinal study analysed written texts obtained from the Australian Longitudinal Study of Women's Health in which participants were…

  13. Grandparenthood and cognitive age: key variables for targeting the over-50 market

    OpenAIRE

    Sudbury Lynn; Simcock Peter

    2010-01-01

    The growing importance of older consumers (aged 50 and above) is evident to marketers in Europe, North America and parts of south east Asia and Australasia. Increasingly, many companies that provide goods and services for children are targeting grandparents in the older consumer market to purchase these goods and services for their grandchildren. Recent marketing literature on the grandparent-grandchild relationship tends to focus solely on the grandchild, and little is known about the impact...

  14. Act your (old) age: prescriptive, ageist biases over succession, consumption, and identity.

    Science.gov (United States)

    North, Michael S; Fiske, Susan T

    2013-06-01

    Perspectives on ageism have focused on descriptive stereotypes concerning what older people allegedly are. By contrast, we introduce prescriptive stereotypes that attempt to control how older people should be: encouraging active Succession of envied resources, preventing passive Consumption of shared resources, and avoidance of symbolic, ingroup identity resources. Six studies test these domains, utilizing vignette experiments and simulated behavioral interactions. Across studies, younger (compared with middle-aged and older) raters most resented elder violators of prescriptive stereotypes. Moreover, these younger participants were most polarized toward older targets (compared with middle-aged and younger analogues)--rewarding elders most for prescription adherences and punishing them most for violations. Taken together, these findings offer a novel approach to ageist prescriptions, which disproportionately target older people, are most endorsed by younger people, and suggest how elders shift from receiving the default prejudice of pity to either prescriptive resentment or reward.

  15. Ageing and Skills: A Review and Analysis of Skill Gain and Skill Loss over the Lifespan and over Time. OECD Education Working Papers, No. 72

    Science.gov (United States)

    Desjardins, Richard; Warnke, Arne Jonas

    2012-01-01

    The relationship between ageing and skills is becoming an important policy issue, not least in the context of population ageing. Data from the Programme for the International Assessment of Adult Competencies (PIAAC) will potentially add considerably to the understanding of the relationship between ageing and foundation skills. In particular, the…

  16. Chemically aged and mixed aerosols over the Central Atlantic Ocean - Potential impacts

    NARCIS (Netherlands)

    Astitha, M.; Kallos, G.; Spyrou, C.; O'Hirok, W.; Lelieveld, J.; Denier Gon, H.A.C. van der

    2010-01-01

    Detailed information on the chemical and physical properties of aerosols is important for assessing their role in air quality and climate. This work explores the origin and fate of continental aerosols transported over the Central Atlantic Ocean, in terms of chemical composition, number and size dis

  17. Modelling the chemically aged and mixed aerosols over the eastern central Atlantic Ocean-potential impacts

    NARCIS (Netherlands)

    Astitha, M.; Kallos, G.; Spyrou, C.; O'Hirok, W.; Lelieveld, J.; Denier Gon, H.A.C. van der

    2010-01-01

    Detailed information on the chemical and physical properties of aerosols is important for assessing their role in air quality and climate. This work explores the origin and fate of continental aerosols transported over the Central Atlantic Ocean, in terms of chemical composition, number and size dis

  18. Effects of Swallowing Training Combined with Real-time Electrical Stimulation on Dysphagia after Stroke in Patients Aged over 80%吞咽训练与实时电刺激结合治疗80岁以上老年人脑卒中后吞咽障碍

    Institute of Scientific and Technical Information of China (English)

    刘立明; 瓮长水; 贾建军; 王娜; 聂永慧

    2010-01-01

    目的 探讨吞咽训练与实时电刺激结合治疗80岁以上老年人脑卒中后的吞咽障碍的疗效.方法 17例80岁以上脑卒中后吞咽障碍的患者采用Vocastim吞咽言语诊治仪进行吞咽训练与实时电刺激结合治疗.治疗前后采用洼田氏饮水试验、吞咽障碍程度分级、吞咽能力评价方法和适应性系数α值进行评价.结果 治疗20次后患者的洼田氏饮水试验、吞咽障碍程度分级、吞咽能力评价方法和适应性系数均有显著改善(P<0.001).结论 吞咽训练与实时电刺激结合治疗可改善高龄老年脑卒中后吞咽障碍患者的吞咽能力.

  19. Development of health over four years among middle-aged and older Europeans

    DEFF Research Database (Denmark)

    Vestergaard, Sonja; Eriksen, Mette Lindholm; Andersen-Ranberg, Karen

    2013-01-01

    Older adults in Eastern and Central European countries have a higher risk of developing poor self-rated health over four years. The same geographical pattern is seen for a higher risk of developing hypertension and diabetes. Low educational level significantly increases the risk of developing poor...

  20. Hemoglobin concentrations in 358 apparently healthy 80-year-old Danish men and women. Should the reference interval be adjusted for age?

    DEFF Research Database (Denmark)

    Milman, N.; Pedersen, A.N.; Ovesen, L.;

    2008-01-01

    Background and aims: In elderly Danes, reference intervals for hemoglobin (Hb) concentrations are derived from younger population groups. The aim was to examine reference intervals for Hb and cut-off limits for anemia by application of criteria for normality to a representative population of 80...

  1. The Asian monsoon over the past 640,000 years and ice age terminations

    Science.gov (United States)

    Cheng, Hai; Edwards, R. Lawrence; Sinha, Ashish; Spötl, Christoph; Yi, Liang; Chen, Shitao; Kelly, Megan; Kathayat, Gayatri; Wang, Xianfeng; Li, Xianglei; Kong, Xinggong; Wang, Yongjin; Ning, Youfeng; Zhang, Haiwei

    2016-06-01

    Oxygen isotope records from Chinese caves characterize changes in both the Asian monsoon and global climate. Here, using our new speleothem data, we extend the Chinese record to cover the full uranium/thorium dating range, that is, the past 640,000 years. The record’s length and temporal precision allow us to test the idea that insolation changes caused by the Earth’s precession drove the terminations of each of the last seven ice ages as well as the millennia-long intervals of reduced monsoon rainfall associated with each of the terminations. On the basis of our record’s timing, the terminations are separated by four or five precession cycles, supporting the idea that the ‘100,000-year’ ice age cycle is an average of discrete numbers of precession cycles. Furthermore, the suborbital component of monsoon rainfall variability exhibits power in both the precession and obliquity bands, and is nearly in anti-phase with summer boreal insolation. These observations indicate that insolation, in part, sets the pace of the occurrence of millennial-scale events, including those associated with terminations and ‘unfinished terminations’.

  2. The Asian monsoon over the past 640,000 years and ice age terminations.

    Science.gov (United States)

    Cheng, Hai; Edwards, R Lawrence; Sinha, Ashish; Spötl, Christoph; Yi, Liang; Chen, Shitao; Kelly, Megan; Kathayat, Gayatri; Wang, Xianfeng; Li, Xianglei; Kong, Xinggong; Wang, Yongjin; Ning, Youfeng; Zhang, Haiwei

    2016-06-30

    Oxygen isotope records from Chinese caves characterize changes in both the Asian monsoon and global climate. Here, using our new speleothem data, we extend the Chinese record to cover the full uranium/thorium dating range, that is, the past 640,000 years. The record's length and temporal precision allow us to test the idea that insolation changes caused by the Earth's precession drove the terminations of each of the last seven ice ages as well as the millennia-long intervals of reduced monsoon rainfall associated with each of the terminations. On the basis of our record's timing, the terminations are separated by four or five precession cycles, supporting the idea that the '100,000-year' ice age cycle is an average of discrete numbers of precession cycles. Furthermore, the suborbital component of monsoon rainfall variability exhibits power in both the precession and obliquity bands, and is nearly in anti-phase with summer boreal insolation. These observations indicate that insolation, in part, sets the pace of the occurrence of millennial-scale events, including those associated with terminations and 'unfinished terminations'. PMID:27357793

  3. Metabolic rate variation over adult lifetime in the butterfly Vanessa cardui (Nymphalidae: Nymphalinae): aging, feeding, and repeatability.

    Science.gov (United States)

    Woods, William A; Wood, C A L; Ebersole, John; Stevenson, R D

    2010-01-01

    Questions about the adaptive importance of metabolic rate can be approached only when measurements of differences between individuals are repeatable. We made daily measurements of CO(2) production, body mass, and food uptake over the adult life span of unmated Vanessa cardui kept under constant environmental conditions in both fed and unfed treatments. Mass and CO(2) production generally declined with age in both treatments, though with much day-to-day variability in the fed treatment. For the full samples, metabolic rate was repeatable for the unfed treatment (repeatability r = 0.60) but not for the fed treatment (r = 0.03). Differences between fed and unfed individuals of the same age range were repeatable for the unfed treatment (r = 0.39) but not for the fed treatment (r = -0.20). Removing age effects on CO(2) production yielded still higher repeatability in the unfed treatment (r = 0.83), though not in fed butterflies of the same age range (r = -0.02). However, repeatability of CO(2) production of fed butterflies increased sharply with age, rising to 0.82 for butterflies age 8-10 d. Although food uptake mass was repeatable (r = 0.52), feeding history explained little variation in CO(2) production. We conclude that for V. cardui and possibly for other insects of similar feeding habit, variation in metabolic rate between individuals is best represented by measurements of unfed individuals of the same age or of older fed individuals.

  4. [Therapeutic strategies of atrial fibrillation in patients aged 65 and over. Report of 86 cases].

    Science.gov (United States)

    Jaafari, Aïcha; Zakhama, Lilia; Boussabah, Ehlem; Thameur, Moez; Boukhriss, Bessma; Amara, Yosser; Masmoudi, Mourad; Bencheikh, Mamoun; Benyoussef, Soraya

    2004-01-01

    Auricular fibrillation is the most common sustained cardiac arrhythmia, yet the optimal strategy for its management remains unclear. Since the study AFFIRM from which resulted them final were deferred in December 2002, the assumption of responsibility of the fibrillation of the old subject tends to become clarified. 86 patients at least 65 years or more were enrolled in our retrospective study from January 1997 to June 2003. The mean age is 70 years (65 to 82 years) and sex ratio to 0.79. 34% had a history of hypertension and 12% had a coronary artery disease. 2 groups were individualized, according to the year of admission before or after 2002. It comes out from these work 2 points: the restoration of the sinusal rhythm was the first choice. In the event of failure, the option was to maintain fibrillation and this, in the 2 groups. The AVK were founded in the large majority of the cases only after year 2002.

  5. Social network analysis - centrality parameters and individual network positions of agonistic behavior in pigs over three different age levels.

    Science.gov (United States)

    Büttner, Kathrin; Scheffler, Katharina; Czycholl, Irena; Krieter, Joachim

    2015-01-01

    Knowledge of the network structure of agonistic interactions helps to understand the formation and the development of aggressive behavior. Therefore, video observation data of 149 pigs over three different age levels were investigated for 2 days each directly after mixing (65 groups in the rearing area, 24 groups in the growing stable and 12 groups in the breeding stable). The aim of the study was to use network analysis to investigate the development of individual network positions of specific animals and to determine whether centrality parameters in previous mixing situations have an impact on the future behavior of the animals. The results of the weighted degree centrality indicated that weaned pigs had a higher fighting intensity directly after mixing compared to growing pigs and gilts. Also, the number of different opponents (degree centrality) was higher compared to the older age groups. The betweenness centrality showed relatively small values and no significant differences between the different age levels, whereas the closeness centrality showed high values at all observed age levels. Experiences gained in previous agonistic interactions had an impact on the centrality parameters in subsequent mixing situations. It was shown that the position of individual animals in agonistic interaction networks can be characterized using social network analysis and that changes over different age levels can be detected. Therefore, social network analysis provides insights into the formation and evolution of behavioral patterns which could be of particular interest for the identification of key factors with regard to abnormal behavior (e.g. tail biting). PMID:25932371

  6. Ice formation and development in aged, wintertime cumulus over the UK: observations and modelling

    Science.gov (United States)

    Crawford, I.; Bower, K. N.; Choularton, T. W.; Dearden, C.; Crosier, J.; Westbrook, C.; Capes, G.; Coe, H.; Connolly, P. J.; Dorsey, J. R.; Gallagher, M. W.; Williams, P.; Trembath, J.; Cui, Z.; Blyth, A.

    2012-06-01

    In situ high resolution aircraft measurements of cloud microphysical properties were made in coordination with ground based remote sensing observations of a line of small cumulus clouds, using Radar and Lidar, as part of the Aerosol Properties, PRocesses And InfluenceS on the Earth's climate (APPRAISE) project. A narrow but extensive line (~100 km long) of shallow convective clouds over the southern UK was studied. Cloud top temperatures were observed to be higher than -8 °C, but the clouds were seen to consist of supercooled droplets and varying concentrations of ice particles. No ice particles were observed to be falling into the cloud tops from above. Current parameterisations of ice nuclei (IN) numbers predict too few particles will be active as ice nuclei to account for ice particle concentrations at the observed, near cloud top, temperatures (-7.5 °C). The role of mineral dust particles, consistent with concentrations observed near the surface, acting as high temperature IN is considered important in this case. It was found that very high concentrations of ice particles (up to 100 L-1) could be produced by secondary ice particle production providing the observed small amount of primary ice (about 0.01 L-1) was present to initiate it. This emphasises the need to understand primary ice formation in slightly supercooled clouds. It is shown using simple calculations that the Hallett-Mossop process (HM) is the likely source of the secondary ice. Model simulations of the case study were performed with the Aerosol Cloud and Precipitation Interactions Model (ACPIM). These parcel model investigations confirmed the HM process to be a very important mechanism for producing the observed high ice concentrations. A key step in generating the high concentrations was the process of collision and coalescence of rain drops, which once formed fell rapidly through the cloud, collecting ice particles which caused them to freeze and form instant large riming particles. The

  7. Ice formation and development in aged, wintertime cumulus over the UK : observations and modelling

    Directory of Open Access Journals (Sweden)

    I. Crawford

    2011-11-01

    Full Text Available In-situ high resolution aircraft measurements of cloud microphysical properties were made in coordination with ground based remote sensing observations of Radar and Lidar as part of the Aerosol Properties, PRocesses And InfluenceS on the Earth's climate (APPRAISE project. A narrow but extensive line (~100 km long of shallow convective clouds over the southern UK was studied. Cloud top temperatures were observed to be higher than ~−8 °C, but the clouds were seen to consist of supercooled droplets and varying concentrations of ice particles. No ice particles were observed to be falling into the cloud tops from above. Current parameterisations of ice nuclei (IN numbers predict too few particles will be active as ice nuclei to account for ice particle concentrations at the observed near cloud top temperatures (~−7 °C. The role of biological particles, consistent with concentrations observed near the surface, acting as potential efficient high temperature IN is considered important in this case. It was found that very high concentrations of ice particles (up to 100 L−1 could be produced by powerful secondary ice particle production emphasising the importance of understanding primary ice formation in slightly supercooled clouds.

    Aircraft penetrations at −3.5 °C, showed peak ice crystal concentrations of up to 100 L−1 which together with the characteristic ice crystal habits observed (generally rimed ice particles and columns suggested secondary ice production had occurred. To investigate whether the Hallett-Mossop (HM secondary ice production process could account for these observations, ice splinter production rates were calculated. These calculated rates and observations could only be reconciled provided the constraint that only droplets >24 μm in diameter could lead to splinter production, was relaxed slightly by 2 μm.

    Model simulations of the case study were also performed with the WRF

  8. Ice formation and development in aged, wintertime cumulus over the UK: observations and modelling

    Directory of Open Access Journals (Sweden)

    I. Crawford

    2012-06-01

    Full Text Available In situ high resolution aircraft measurements of cloud microphysical properties were made in coordination with ground based remote sensing observations of a line of small cumulus clouds, using Radar and Lidar, as part of the Aerosol Properties, PRocesses And InfluenceS on the Earth's climate (APPRAISE project. A narrow but extensive line (~100 km long of shallow convective clouds over the southern UK was studied. Cloud top temperatures were observed to be higher than −8 °C, but the clouds were seen to consist of supercooled droplets and varying concentrations of ice particles. No ice particles were observed to be falling into the cloud tops from above. Current parameterisations of ice nuclei (IN numbers predict too few particles will be active as ice nuclei to account for ice particle concentrations at the observed, near cloud top, temperatures (−7.5 °C.

    The role of mineral dust particles, consistent with concentrations observed near the surface, acting as high temperature IN is considered important in this case. It was found that very high concentrations of ice particles (up to 100 L−1 could be produced by secondary ice particle production providing the observed small amount of primary ice (about 0.01 L−1 was present to initiate it. This emphasises the need to understand primary ice formation in slightly supercooled clouds. It is shown using simple calculations that the Hallett-Mossop process (HM is the likely source of the secondary ice.

    Model simulations of the case study were performed with the Aerosol Cloud and Precipitation Interactions Model (ACPIM. These parcel model investigations confirmed the HM process to be a very important mechanism for producing the observed high ice concentrations. A key step in generating the high concentrations was the process of collision and coalescence of rain drops, which once formed fell rapidly through the cloud, collecting ice particles which caused them

  9. Hemoglobin concentrations in 358 apparently healthy 80-year-old Danish men and women. Should the reference interval be adjusted for age?

    DEFF Research Database (Denmark)

    Milman, N.; Pedersen, Agnes Nadelmann; Ovesen, Lars;

    2008-01-01

    Background and aims: In elderly Danes, reference intervals for hemoglobin (Hb) concentrations are derived from younger population groups. The aim was to examine reference intervals for Hb and cut-off limits for anemia by application of criteria for normality to a representative population of 80......-95 percentile 114-147 g/L in women (p= 20 had a lower frequency of anemia. There was no correlation between Hb and dietary or supplemental iron intake. In men, Hb was correlated to meat consumption. Conclusions: WHO decision limits for anemia should not be lowered in 80-year-old subjects. "Optimal" Hb...... concentrations with respect to survival appear to be at least 140 g/L in men and 131 g/L in women. Further research should evaluate whether not only treating anemia, but also increasing Hb by using erythropoietin and hematinics, may improve functional status and survival in the elderly....

  10. Oral health of individuals aged 3-80 years in Jönköping, Sweden during 30 years (1973-2003). II. Review of clinical and radiographic findings.

    Science.gov (United States)

    Hugoson, Anders; Koch, Göran; Göthberg, Catharina; Helkimo, Anna Nydell; Lundin, Sven-Ake; Norderyd, Ola; Sjödin, Bengt; Sondell, Katarina

    2005-01-01

    The aim of this epidemiological study was to analyze various clinical and radiographic data on oral health and compare the results to those of three cross-sectional studies carried out in 1973 and 1983, and 1993. In 1973, 1983, 1993, and 2003 a random sample of 1,000; 1,104; 1,078; and 987 individuals, respectively, were studied. The individuals were evenly distributed in the age groups 3, 5, 10, 15, 20, 30, 40, 50, 60, 70, and 80 years. In 1973 80-year-olds were not included. All subjects were inhabitants of the City of Jönköping, Sweden. The clinical and radiographic examination assessed edentulousness, removable dentures, implants, number of teeth, caries, restorations and overhangs, oral hygiene, calculus, periodontal status, endodontic treatment, and periapical status. The number of edentulous individuals in the age groups 40-70 years was reduced from 16 per cent in 1973 to 8 per cent in 1993, and to 1 per cent in 2003. The mean number of teeth increased, and up to the age of 60 years, individuals had more or less complete dentitions. During the 30-year period,the number of carious lesions and restorations decreased in general. In the 15-year-olds the decrease in number of restored tooth surfaces was 900 per cent and the corresponding figure for 30-year-olds was 79 per cent. The age groups 60-800 years showed an increase in number of restored tooth surfaces and had as a mean 50 filled tooth surfaces. The oral health among 3-5-year-olds improved markedly between 1973 and 1993. In 2003, however, there was no further improvement in 3- and 5-year-olds compared to 1993. Generally, restorations in 2003 exhibited a high quality and 90-95 per cent had no proximal overhangs. In 1973 this figure was about 60 per cent. In the age groups 20-50 years there were continuously fewer teeth fitted with crowns or bridges during the 30-year period. In 1973 the 50-year-olds had a mean of 24.5 per cent of the teeth crowned and in 2003 6.8 percent. Compared to data from 1973 there

  11. Osteoporosis, vitamin C intake, and physical activity in Korean adults aged 50 years and over.

    Science.gov (United States)

    Kim, Min Hee; Lee, Hae-Jeung

    2016-03-01

    [Purpose] To investigate associations between vitamin C intake, physical activity, and osteoporosis among Korean adults aged 50 and over. [Subjects and Methods] This study was based on bone mineral density measurement data from the 2008 to 2011 Korean National Health and Nutritional Examination Survey. The study sample comprised 3,047 subjects. The normal group was defined as T-score ≥ -1.0, and the osteoporosis group as T-score ≤ -2.5. The odds ratios for osteoporosis were assessed by logistic regression of each vitamin C intake quartile. [Results] Compared to the lowest quartile of vitamin C intake, the other quartiles showed a lower likelihood of osteoporosis after adjusting for age and gender. In the multi-variate model, the odds ratio for the likelihood of developing osteoporosis in the non-physical activity group significantly decreased to 0.66, 0.57, and 0.46 (p for trend = 0.0046). However, there was no significant decrease (0.98, 1.00, and 0.97) in the physical activity group. [Conclusion] Higher vitamin C intake levels were associated with a lower risk of osteoporosis in Korean adults aged over 50 with low levels of physical activity. However, no association was seen between vitamin C intake and osteoporosis risk in those with high physical activity levels.

  12. Characteristics and Use of Home Health Care by Men and Women Aged 65 and Over

    Science.gov (United States)

    ... to receive services that were associated with post-acute care such as wound care and physical therapy. In contrast, women were ... nonspousal) family member . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 § 7 14 § 7 Post-acute care Yes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 § 59 49 § 58 Length of service (in ... care . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 § 18 12 § 18 Dietary counseling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 ...

  13. Physical activity and cognitive function in individuals over 60 years of age: a systematic review

    Directory of Open Access Journals (Sweden)

    Carvalho A

    2014-04-01

    Full Text Available Ashley Carvalho,1,2 Irene Maeve Rea,2 Tanyalak Parimon,3,4 Barry J Cusack3,51Department of Public Health, 2School of Medicine, Dentistry and Biomedical Science, Queen’s University Belfast, Northern Ireland, UK; 3Research and Development Service, Veterans Affairs Medical Center, Boise, ID, USA; 4Division of Pulmonary and Critical Care Medicine, 5Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, USABackground: It is unclear whether physical activity in later life is beneficial for maintenance of cognitive function. We performed a systematic review examining the effects of exercise on cognitive function in older individuals, and present possible mechanisms whereby physical activity may improve cognition.Methods: Sources consisted of PubMed, Medline, CINAHL, the Cochrane Controlled Trials Register, and the University of Washington, School of Medicine Library Database, with a search conducted on August 15, 2012 for publications limited to the English language starting January 1, 2000. Randomized controlled trials including at least 30 participants and lasting at least 6 months, and all observational studies including a minimum of 100 participants for one year, were evaluated. All subjects included were at least 60 years of age.Results: Twenty-seven studies met the inclusion criteria. Twenty-six studies reported a positive correlation between physical activity and maintenance or enhancement of cognitive function. Five studies reported a dose-response relationship between physical activity and cognition. One study showed a nonsignificant correlation.Conclusion: The preponderance of evidence suggests that physical activity is beneficial for cognitive function in the elderly. However, the majority of the evidence is of medium quality with a moderate risk of bias. Larger randomized controlled trials are needed to clarify the association between exercise and cognitive function and to determine

  14. Maxillofacial injuries and dental trauma in patients aged 19-80 years, Recife, Brazil Lesiones maxilofaciales y traumatismo dental en pacientes de 19 a 80 años, Recife, Brasil

    Directory of Open Access Journals (Sweden)

    A. Leite Cavalcanti

    2010-03-01

    Full Text Available Aim: A retrospective study was undertaken to assess causes of maxillofacial trauma in Recife, Pernambuco, Brazil. Method: A review of 186 patients with maxillofacial injuries aged 19 and 83 years old seen and treated at the Hospital da Restauração between January and December 2006 was conducted and were analyzed according to age, sex, etiology, site of fracture, dentoalveolar trauma and alcohol abuse. Analysis was made in Epi Info using the Chi-square and Fisher´s Exact Tests. Results: It was found that maxillofacial injuries were most frequent in males (89.2% and in the 19-28 year age group (46.8%. Traffic accidents/motorcycle (23.7% and physical violence (20.4% were the most common etiological factor. Facial fractures were detected in 90.9% and a statistically significant difference between sex and facial fracture was found (p = 0.000. The most common facial fracture was maxilla (29.1%, followed by the mandible (27.5%. A positive association between the presence of facial fracture and alcohol consumption was observed (p = 0.002. Dentoalveolar trauma was present in 7.5% of patients. Conclusion: The incidence of facial fractures in Brazilian population is similar than previously reported elsewhere. There were most common in male patients, mainly due to traffic accidents/motorcycle and physical violence.Objetivo: Se llevó a cabo un estudio retrospectivo para evaluar las causas de traumatismo maxilofacial en Recife, Pernambuco, Brasil. Método: Se hizo una revisión de 186 pacientes con lesiones maxilofaciales de 19 a 83 años atendidos y tratados en el Hospital da Restauração entre Enero y Diciembre 2006, analizándoles según edad, sexo, etiología, localización de la fractura, traumatismo dentoalveolar y abuso de alcohol. Se llevó a cabo el análisis en Epi Info, utilizando el Chi cuadrado y la prueba exacta de Fisher. Resultados: Resultó que las lesiones maxilofaciales fueron más frecuentes en los hombres (89,2% y en el grupo de edad

  15. Petrography, age, and paleomagnetism of basalt lava flows in coreholes Well 80, NRF 89-04, NRF 89-05, and ICPP 123, Idaho National Engineering Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Lanphere, M.A.; Champion, D.E. [Geological Survey, Menlo Park, CA (United States); Kuntz, M.A. [Geological Survey, Denver, CO (United States)

    1993-12-31

    The petrography, age, and paleomagnetism were determined on basalt from 23 lava flows comprising about 1200 feet of core from four coreholes in the Idaho National Engineering Laboratory (ML). The four coreholes are located in the southwestern part of the INEL. Paleomagnetic measurements were made on 192 samples of basalt, and K-Ar ages were measured on 19 basalt samples. All of the samples have normal magnetic polarity and were erupted during the Brunhes Normal Polarity Epoch. Basalt lava flows in ICPP 123 can be satisfactorily correlated with lava flows in the previously studied corehole at Site E, but correlations cannot be made with confidence between ICPP 123 and the other three coreholes studied in this investigation.

  16. Age Spectra and Transport Rates in the UTLS over the Tropics and the North American Monsoon Region

    Science.gov (United States)

    Pittman, J. V.; Wofsy, S. C.; Daube, B. C.; Budney, J.; Commane, R.; Lindaas, J.; McKain, K.; Samra, J.; Santoni, G.; Sargent, M. R.; Smith, J. B.; Anderson, J. G.; Gao, R. S.; Rollins, A. W.; Thornberry, T. D.; Watts, L. A.; Hintsa, E. J.; Moore, F. L.; Elkins, J. W.; Andrews, A. E.; Atlas, E. L.; Navarro, M. A.; Wang, T.; Dessler, A. E.

    2014-12-01

    The Upper Troposphere / Lower Stratosphere (UTLS) plays a significant role in controlling the chemical composition and the radiative property of the stratosphere. Transport and mixing processes with time scales ranging from a few hours (e.g., convection) to several months (e.g., slow ascent) have been previously observed in this region of the atmosphere. While the tropics act as the dominant gateway for air entering the stratosphere, monsoon regions have recently gained significant interest as sources of direct injection of surface air into the extratropical stratosphere, bypassing the thermal and chemical control of the tropics. In this study, we use high-altitude aircraft measurements of chemical tracers with different atmospheric lifetimes to investigate the aforementioned processes. These measurements were recently collected over the tropics during the NASA ATTREX campaign and over the North American Monsoon (NAM) region during the NASA SEAC4RS campaign. In addition, we use surface station data and trajectory analysis in order to elucidate the chemical and dynamical context of the aircraft measurements. Our goals are twofold: (i) examine the age of air and age spectra in the UTLS over the tropics and the NAM region, and (ii) examine the transport rates linking the tropics and midlatitudes at UTLS altitudes. This study is primarily based upon the analysis of greenhouse gas data, in particular CO2. This tracer has a well-defined seasonal cycle driven by biosphere-atmosphere interactions and an annual trend driven by anthropogenic activity. This 'clock-like' property makes it a useful tracer for studying transport timescales. This information is then complemented by process-specific information given by additional chemical tracers such as H2O, O3, CO, and short-lived hydrocarbons. Multi-tracer aircraft data from more than 150 vertical profiles over the tropical Pacific and over 50 vertical profiles over the NAM region between Jan 2013 and Mar 2014 provide

  17. CHILD ALLOWANCE FOR CHILDREN AGED 18 AND OVER AND REIMBURSEMENT OF EDUCATION FEES

    CERN Document Server

    HR Division

    2001-01-01

    Human Resources Division wishes to draw the attention of members of personnel to paragraph 8 of Administrative Circular N° 5 (Dependent Child) and reminds them that if employment is taken up, the child is no longer considered dependent. In particular, the undertaking of teaching activities during the study period can be considered as taking up employment. Human Resources Division also wishes to draw the attention of members of personnel to Article RIV 1.13 of the Regulations and reminds them that the amount of any financial benefits received from outside the Organization shall be deducted from the benefits paid by the Organization in the same area. Grants, allowances and salaries paid to trainees who benefit from the reimbursement of their education fees, will therefore be deducted from the amount paid by CERN.

  18. Effects of Acute 60 and 80% V[o.sub.2]max Bouts of Aerobic Exercise on State Anxiety of Women of Different Age Groups across Time

    Science.gov (United States)

    Cox, Richard H.; Thomas, Tom R.; Hinton, Pam S.; Donahue, Owen M.

    2004-01-01

    The purpose of this investigation was to study the effects of an acute bout of aerobic exercise on state anxiety of women while controlling for iron status (hemoglobin and serum ferritin). Participants were 24 active women, ages 18-20 years (n=12) and 35-45 years (n=12). In addition to a nonexercise control condition, participants completed one…

  19. Culture of skeletal myoblasts from human donors aged over 40 years: dynamics of cell growth and expression of differentiation markers

    Directory of Open Access Journals (Sweden)

    Cherubino Paolo

    2005-05-01

    Full Text Available Abstract Background Local myogenesis, neoangiogenesis and homing of progenitor cells from the bone marrow appear to contribute to repair of the infarcted myocardium. Implantation into heart tissues of autologous skeletal myoblasts has been associated with improved contractile function in animal models and in humans with acute myocardial ischemia. Since heart infarction is most prevalent in individuals of over 40 years of age, we tested whether culture methods available in our laboratory were adequate to obtain sufficient numbers of differentiated skeletal myoblasts from muscle biopsy specimens obtained from patients aged 41 to 91. Methods and results No matter of donor age, differentiated skeletal muscle cells could be produced in vitro in amounts adequate for cellular therapy (≥300 millions. Using desmin as a cytoplasmic marker, about 50% cultured cells were differentiated along myogenic lineages and expressed proteins proper of skeletal muscle (myosin type I and II, actin, actinin, spectrin and dystrophin. Cytogenetic alterations were not detected in cultured muscle cells that had undergone at least 10 population doublings. Molecular methods employed for the screening of persistent viral infections evidenced that HCV failed to replicate in muscle cells cultured from one patient with chronic HCV infection. Conclusion The proposed culture methods appear to hold promise for aged patients not only in the field of cardiovascular medicine, but also in the urologic and orthopedic fields.

  20. Smoking, antioxidant supplementation and dietary intakes among older adults with age-related macular degeneration over 10 years.

    Directory of Open Access Journals (Sweden)

    Bamini Gopinath

    Full Text Available We aimed to compare the micronutrient usage and other lifestyle behaviors over 10 years among those with and without age-related macular degeneration (AMD. 1612 participants aged 49+ years at baseline were re-examined over 10 years, west of Sydney, Australia. AMD was assessed from retinal photographs. Dietary data were collected using a semi-quantitative food frequency questionnaire. Smoking status was self-reported. 56 participants had any AMD at baseline, of these 25% quit smoking at 5 years and were still not smoking at 10-year follow-up. Among participants who had below the recommended intake of vitamins A, C or E supplements at baseline, those who did compared to those who did not develop late AMD over 10 years were more likely to report vitamins A (total, C or E supplement intake above the recommended intake at 10-year follow-up: multivariable-adjusted OR 4.21 (95% CI 1.65-10.73; OR 6.52 (95% CI 2.76-15.41; and OR 5.71 (95% CI 2.42-13.51, respectively. Participants with compared to without AMD did not appreciably increase fish, fruit and vegetable consumption and overall diet quality. Adherence to smoking and dietary recommendations was poor among older adults with AMD. However, uptake of antioxidant supplements increased significantly among those with late AMD.

  1. Uranium-series coral ages from the US Atlantic Coastal Plain-the "80 ka problem" revisited

    Science.gov (United States)

    Wehmiller, J. F.; Simmons, K.R.; Cheng, H.; Edwards, R. Lawrence; Martin-McNaughton, J.; York, L.L.; Krantz, D.E.; Shen, C.-C.

    2004-01-01

    Uranium series coral ages for emergent units from the passive continental margin US Atlantic Coastal Plain (ACP) suggest sea level above present levels at the end of marine oxygen isotope stage (MIS) 5, contradicting age-elevation relations based on marine isotopic or coral reef models of ice equivalent sea level. We have reexamined this problem by obtaining high precision 230Th/238U and 231Pa/235U thermal ionization mass spectrometric ages for recently collected and carefully cleaned ACP corals, many in situ. We recognize samples that show no evidence for diagenesis on the basis of uranium isotopic composition and age concordance. Combining new and earlier data, among those ages close to or within the age range of MIS 5, over 85% cluster between 65 and 85 ka BP. Of the corals that we have analyzed, those that show the least evidence for diagenesis on the basis of uranium isotopic composition and age concordance have ages between 80 and 85 ka BP, consistent with a MIS 5a correlation. The units from which these samples have been collected are all emergent and have elevations within ???3-5m of those few units where early stage 5 (???125,000 ka BP) coral ages have been obtained. The ACP appears to record an unusual history of relative sea level throughout MIS 5, a history that is also apparent in the dated coral record for Bermuda. We speculate that this history is related to the regional (near-to intermediate-field) effects of ancestral Laurentide Ice sheets on last interglacial shorelines of the western North Atlantic. ?? 2004 Elsevier Ltd and INQUA. All rights reserved.

  2. The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice.

    Science.gov (United States)

    Kitaoka, Kazuyoshi; Shimizu, Noriyuki; Ono, Koji; Chikahisa, Sachiko; Nakagomi, Madoka; Shudo, Koichi; Ishimura, Kazunori; Séi, Hiroyoshi; Yoshizaki, Kazuo

    2013-09-01

    The retinoic acid (RA, a vitamin A metabolite) receptor (RAR) is a transcription factor. Vitamin A/RA administration improves the Alzheimer's disease (AD)- and age-related attenuation of memory/learning in mouse models. Recently, a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) was identified as a key molecule in RA-mediated anti-AD mechanisms. We investigated the effect of chronic administration of the RAR agonist Am80 (tamibarotene) on ADAM10 expression in senescence-accelerated mice (SAMP8). Moreover, we estimated changes in the expression of the amyloid precursor protein (APP), amyloid beta (Aβ), and hairy/enhancer of split (Hes), which are mediated by ADAM10. Spatial working memory and the levels of a hippocampal proliferation marker (Ki67) were also assessed in these mice. ADAM10 mRNA and protein expression was significantly reduced in the hippocampus of 13-month-old SAMP8 mice; their expression improved significantly after Am80 administration. Further, after Am80 administration, the expression levels of Hes5 and Ki67 were restored and the deterioration of working memory was suppressed, whereas APP and Aβ levels remained unchanged. Our results suggest that Am80 administration effectively improves dementia by activating the hippocampal ADAM10-Notch-Hes5 proliferative pathway. PMID:23624141

  3. Spectral-domain optical coherence tomography in subjects over 60 years of age, and its implications for designing clinical trials

    OpenAIRE

    Caramoy, Albert; Foerster, Jonathan; Allakhiarova, Elvira; Hoyng, Carel B.; Dröge, Katharina; Kirchhof, Bernd; Fauser, Sascha

    2012-01-01

    Aims To study the variability of central retinal thickness (CRT), its concordance to the fellow eye, and the implications for designing future clinical trials using spectral-domain optical coherence tomography (SD-OCT). Methods Cross-sectional retrospective analysis of European Genetic Database. 632 eyes of 316 subjects over 60 years of age without macular pathology were examined using SD-OCT. Results Mean CRT was 280.22 µm and 281.02 µm for the right and left eyes, respectively. There was a ...

  4. Tree Age Effects on Fine Root Biomass and Morphology over Chronosequences of Fagus sylvatica, Quercus robur and Alnus glutinosa Stands.

    Science.gov (United States)

    Jagodzinski, Andrzej M; Ziółkowski, Jędrzej; Warnkowska, Aleksandra; Prais, Hubert

    2016-01-01

    There are few data on fine root biomass and morphology change in relation to stand age. Based on chronosequences for beech (9-140 years old), oak (11-140 years) and alder (4-76 years old) we aimed to examine how stand age affects fine root biomass and morphology. Soil cores from depths of 0-15 cm and 16-30 cm were used for the study. In contrast to previously published studies that suggested that maximum fine root biomass is reached at the canopy closure stage of stand development, we found almost linear increases of fine root biomass over stand age within the chronosequences. We did not observe any fine root biomass peak in the canopy closure stage. However, we found statistically significant increases of mean fine root biomass for the average individual tree in each chronosequence. Mean fine root biomass (0-30 cm) differed significantly among tree species chronosequences studied and was 4.32 Mg ha(-1), 3.71 Mg ha(-1) and 1.53 Mg ha(-1), for beech, oak and alder stands, respectively. The highest fine root length, surface area, volume and number of fine root tips (0-30 cm soil depth), expressed on a stand area basis, occurred in beech stands, with medium values for oak stands and the lowest for alder stands. In the alder chronosequence all these values increased with stand age, in the beech chronosequence they decreased and in the oak chronosequence they increased until ca. 50 year old stands and then reached steady-state. Our study has proved statistically significant negative relationships between stand age and specific root length (SRL) in 0-30 cm soil depth for beech and oak chronosequences. Mean SRLs for each chronosequence were not significantly different among species for either soil depth studied. The results of this study indicate high fine root plasticity. Although only limited datasets are currently available, these data have provided valuable insight into fine root biomass and morphology of beech, oak and alder stands.

  5. Children’s exposures to water and sand at the beach: Findings from studies of over 80,000 subjects at 13 beaches

    Science.gov (United States)

    Swimming and recreating in lakes, oceans, and rivers is common among adults and children; some studies have suggested that children may be at greater risk of illness following such exposures. Such differences might be due to differences in immunity or differing behavioral factors...

  6. 80a-Oscillation of Summer Rainfall over the East Part of China and East-Asian Summer Monsoon%中国东部夏季降水80年振荡与东亚夏季风的关系

    Institute of Scientific and Technical Information of China (English)

    朱锦红; 王绍武

    2001-01-01

    Relationship between summer rainfall over the east part of China and East-Asian Summer Monsoon (EASM) was studied based on the summer rainfall grade data set from 1470 to 1999 and the rain gauge data set from 1951 to 1999 over the east part of China, and sea level pressure (SLP) data for the period of 1871-2000. A distinct 80a-oscillation of summer rainfall was found over North China (NC), southern part of Northeast China, over the middle and lower reaches of the Yangtze River (YR) and South China (SC). The 80a oscillation of summer rainfall over NC was varied in phase with that over SC, and was out of phase to that along the middle and lower reaches of the Yangtze River. Summer rainfall over NC correlated negatively with the SLP averaged for the area from 105°E to 120°E, and from 30°N to 35°N, but positively to that for the area from 120°E to 130°E, and from 20°N to 25°N. Therefore, an index of EASM was de fined by the difference of averaged SLP over the two regions. The summer rainfall over NC was greater than normal when the EASM was strong, and while drought occurred along the middle and lower reaches of the Yangtze River. The drought was found over NC, and flood along the middle and lower reaches of the Yangtze River when the EASM was close to normal. Finally, the interdecadal variability of EASM was stu died by using of long term summer rainfall grade data set over NC for the past 530 years.%利用中国东部1470-1999年夏季降水级别资料和1951-1999年夏季降水观测资料,以及187l-2000年北半球海平面气压资料研究了中国东部夏季降水与东亚夏季风的关系。研究表明华北及东北南部、长江中下游地区和华南夏季降水存在明显的80年振荡,华北夏季降水的80年振荡与华南同位相,与长江中下游反位相。华北夏季降水与海平面气压在120°-130°E,20°-25°N区域内呈负相关,在120°-130°E,20°-25°N区域内呈正相关,并达到95%信度。因此,

  7. Psychological need satisfaction and well-being in adults aged 80 years and older living in residential homes: using a self-determination theory perspective.

    Science.gov (United States)

    Ferrand, Claude; Martinent, Guillaume; Durmaz, Neriman

    2014-08-01

    Based on the self-determination theory (SDT), this study aims to examine the psychological needs satisfaction of the elderly living in residential homes and their relationship with indicators of well-being, and then to test the contribution of each need on these indicators. Participants (N=100; Mage=86.7 years, SD=3.78) completed the measures of psychological needs satisfaction, purpose in life, personal growth and geriatric depression. Cluster analyses showed two distinct profiles: one profile with a high satisfaction of the three basic psychological needs and another profile with a low satisfaction of the three basic psychological needs. These profiles did not differ in terms of residents' characteristics, health problems and functional limitations. Multivariate analysis of variance (MANOVA) results revealed that the participants with the profile of a high satisfaction of psychological needs have significantly higher levels of purpose in life and personal growth than participants with the profile of a low satisfaction of psychological needs, and no effect of cluster membership on depressive feelings was reported. Moreover, for all participants, relatedness need satisfaction was significantly and positively related to personal growth, and autonomy and relatedness needs satisfaction was related to purpose of life. In conclusion, our results offer evidence that old age can be fruitful and, in consistent with SDT, show that autonomy and relatedness need satisfaction is positively associated with indicators of well-being such as purpose in life and personal growth, considered as essential components of optimal functioning.

  8. [The age of Gutenberg is over: a consideration of medical education--past, present and future].

    Science.gov (United States)

    Burg, G; French, L E

    2012-04-01

    Education is the basis for reliable medical care and medical progress. Our medical knowledge has increased more in the past 50 years than in the 500 years before. The spatial and human resource capacity of our universities cannot cope with the existing academic structures and needs. Part of the problem can be solved by "blended learning", that is a combination of traditional teaching methods (frontal lectures, courses, bedside teaching) with supplementary web-based e-learning. In addition to conveying a sound basic knowledge, the ability to cope with modern media and prepare for lifelong learning must also be taught. Out of the large number of e-learning platforms for undergraduate students offered in the internet, we present the program DOIT (Dermatology Online with Interactive Technology; http://www.swisdom.org) and the program Dermokrates (http://www.Dermokrates.com) of the German, Austrian and Swiss Dermatological Societies for postgraduate Continuing Medical Education (CME). The biggest obstacle in the implementation of new developments is the stubborn adherence to traditional structures.

  9. Pharmacokinetics and dose requirements of factor VIII over the age range 3-74 years

    DEFF Research Database (Denmark)

    Björkman, Sven; Folkesson, Anna; Jönsson, Siv

    2009-01-01

    PURPOSE: The three aims of this investigation were (1) to develop a population pharmacokinetic (PK) model for factor VIII (FVIII) in haemophilia A patients, with estimates of inter-occasion and inter-individual variance, (2) to investigate whether appropriate dosing of FVIII for regular prophylaxis...

  10. Urinary Incontinence, Related Factors and Depression among 20 Aged and Over Women in Beylikova District Centre in Eskisehir

    Directory of Open Access Journals (Sweden)

    Alaettin Unsal

    2013-06-01

    Full Text Available Aim: To determination of prevalence of Urinary incontinence (UI, and to evaluation of relationship between UI and depression in women. Material and methods: This study is a cross-sectional type research, was realized between 05 July 2011 to 25 August 2011, among 20 and over aged women that living in Beylikova district centre. The study group was occurred 500 women. The presence of UI, its type and severity were evaluated according to criteria recommended by the International Continence Society. For the purpose of the questionnaire form prepared by the study, households were visited one by one, filled with face to face method. Beck Depression Inventory (BDI was used for evaluation of depression. Chi-square test and Logistic Regression Analyses were used in statistical analyses. For statistical significance, p<0.05 were approved. Results: The ages of women were between 20 to 81 years, and average age was 46.97±15.65 years. Prevalence of UI was found 41.4% (n=207. Of the UI cases were 35.7% stress incontinence, 15.5% urge incontinence, 48.8% mixed type. Of the cases were 95 (45.9% low severity, 60 (29.0% middle severity, 52 (25.1% high severity. In this study, UI was an important risk factor in illiterates (OR: 6.617, no smoking (OR: 1.868, obes (OR: 2.777, persons with anyone chronicle disease that diagnosed by doctor (OR: 4.711, enuresis nocturna hystory in childhood age (OR: 2.600, large baby history in women who had given birth (OR: 1.947, and menopause (OR: 2.497. Prevalence of depression was found 25.4% (n=127. Prevalence of depression was higher found in the women with UI, stress type UI, and high severity UI (for each one; p<0.05. Conclusion: In this study, it was determinate that UI an important health problem in the women, and depression prevalence was higher in the women with UI. [TAF Prev Med Bull 2013; 12(3.000: 231-242

  11. Pregnancy Outcome of Multiparous Women Aged over 40 Years.

    Science.gov (United States)

    Ates, Seda; Batmaz, Gonca; Sevket, Osman; Molla, Taner; Dane, Cem; Dane, Banu

    2013-01-01

    Objective. The aim of this study was to evaluate the effect of maternal age on prenatal and obstetric outcome in multiparaous women. Materials and Methods. A retrospective case control study was conducted, including women aged 40 years and over (study group, n = 97) who delivered at 20 week's gestation or beyond and women aged 20-29 years (control group, n = 97). Results. The mean age of women in the study group was 41.2 ± 1.7 years versus 25.4 ± 2.3 years in the control group. Advanced maternal age was associated with a significantly higher rate of hypertension, diabetes mellitus, fetal complication, and 5-minute Apgar scores <7 (P < 0.05). Caeserean section rate, incidence of placental abruption, preterm delivery, and neonatal intensive care unit admission were more common in the older group, but the differences were not statistically significant. Conclusions. Advanced maternal age is related to maternal and neonatal complications.

  12. It's Never over until It's over: How Can Age and Ovarian Reserve Be Mathematically Bound through the Measurement of Serum AMH-A Study of 5069 Romanian Women.

    Directory of Open Access Journals (Sweden)

    Bogdan Doroftei

    Full Text Available Wide regional differences in the age-related Anti Mullerian hormone (AMH regression patterns or age at onset of natural menopause have been reported, possibly reflecting genetic, socioeconomic, environmental, racial or ethnic peculiarities. Moreover, adaptation of AMH levels from different assays using regression functions may lack accuracy and externally defined references for AMH levels may not fully comply with a specific geographical area. The current study aimed to establish an accurate mathematical relationship between AMH serum values and age in a large group of women from Romania, as any consistent difference from previously reported regression models may aid in building specific profiles for the AMH decline with age in this geographical region. Our study pointed out to the quadratic regression as the most fitted pattern of correlation for all the age groups between 24 and 45. To our knowledge the current manuscript is based on the singular study carried out in this geographical region, generating a particular age-related pattern of association between age and serum AMH levels in women, regardless of their subjacent pathologies.

  13. Accidente cerebrovascular isquémico en mayores de 80 años Acute ischemic stroke in patients aged 80 or older

    Directory of Open Access Journals (Sweden)

    Juan I Rojas

    2007-12-01

    Full Text Available En los pacientes de edad avanzada, el perfil de factores de riesgo vascular y el subtipo de accidente cerebrovascular (ACV es diferente en comparación con pacientes más jóvenes. El objetivo del presente trabajo fue describir el perfil de factores de riesgo y subtipo de ACV isquémico en nuestra población de pacientes ancianos. Incluimos a pacientes mayores de 80 años con diagnóstico de ACV isquémico y ataque isquémico transitorio (AIT entre junio de 2003 y junio de 2006. De 535 pacientes con eventos cerebrovasculares isquémicos, en 366 casos el diagnóstico fue de ACV y 169 de AIT. El 33.5% (179 pacientes fueron mayores de 80 años. La edad media fue de 84.4 ± 4.4 años. Los factores de riesgo más frecuentes fueron: hipertensión arterial 82.7%, dislipemia 40.2% y fibrilación auricular 24.6%. El subtipo de ACV que se presentó con mayor frecuencia fue la enfermedad de pequeñas arterias en un 41.7%, seguido por el evento cardioembólico en el 19.7%, enfermedad de gran arteria 6%, otras causas en el 0.8%. De los factores de riesgo vasculares tradicionales, los más significativos fueron hipertensión e hipercolesterolemia. Estos datos son coincidentes con estudios epidemiológicos previos y explican la mayor incidencia de infartos lacunares.Young and old age stroke groups have different vascular risk profiles for cerebral ischemic events. The objective of the study was to describe the risk factor profile and stroke subtype in this population of very elderly people. We included patients over 80 years old with diagnosis of ischemic stroke and transient ischemic attack registered between June 2003 and June 2006. We described the demographic data and subtype of ischemic stroke. Of 535 patients with cerebrovascular ischemic events, the final diagnosis was stroke in 366 cases and transient ischemic attack in 169. Of these patients 33.5% were over 80 years old (179. The mean age was 84.4 ± 4.4 years. The most frequent risk factors were

  14. Cleft deformities in adults and children aged over six years in Nigeria: Reasons for late presentation and management challenges

    Directory of Open Access Journals (Sweden)

    Wasiu L Adeyemo

    2009-11-01

    Full Text Available Wasiu L Adeyemo1, Mobolanle O Ogunlewe1, Ibironke Desalu2, Akinola L Ladeinde1, Bolaji O Mofikoya3, Michael O Adeyemi4, Adegbenga A Adepoju4, Olufemi O Hassan41Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, 2Department of Anaesthesia, 3Department of Surgery, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria; 4Department of Oral and Maxillofacial Surgery, Lagos University Teaching Hospital, Lagos, NigeriaAbstract: In developing countries, untreated cleft lips and palates are found with increasing frequency and patients often present to the surgeon far past the optimal time for closure of the cleft deformities. A prospective study was conducted between March 2007 and September 2009, to identify the reasons and treatment challenges of delayed presentation of cleft lip and palate deformities at the Lagos University Teaching Hospital, Nigeria. Out of a total of 150 patients with cleft defects during the period, 43 (28.7% were adults and children aged over six years. The mean age of these patients at the time of presentation was 17.3 years. The most common reasons for late presentation were lack of money (56.7%, lack of health care services nearby (18.4%, and lack of awareness of treatment availability (13.3%. Common challenges in these patients included surgical, orthodontic, speech, anesthetic, and psychological. Although adult clefts were significantly enlarged in three dimensions the anatomic landmarks were easier to discern than in an infant. However, extensive soft tissue dissection in adult cleft lip repair resulted in significant postoperative edema. Closure of wide palatal cleft often required the use of adjunct intraoral flaps. Despite late presentation, surgical outcome of these patients was satisfactory and comparable to cleft repair in infants.Keywords: cleft deformities, adults, adolescents, late presentation, management, challenges

  15. Adherence to and appropriateness of anti-osteoporotic treatments in patients aged 50 and over in the Valencia Region (Spain). The ESOSVAL-AD Study

    OpenAIRE

    Ruiz Vicente; Usó Ruth; Trillo José; Hurtado Isabel; Peiró Salvador; Sanfélix-Genovés José; Sanfélix-Gimeno Gabriel; de la Torre Manuel; Ferreros Inmaculada

    2011-01-01

    Summary Background A study to evaluate the adherence to and appropriateness of anti-osteoporotic treatments in a cohort of men and women aged 50 and over participating in the ESOSVAL-R study. Methods/Design Design: An observational, longitudinal, prospective cohort study; Study subjects: Men and women aged 50 and over living in the Valencia Region (Spain) who initiated treatment between June 15, 2009, and June 15, 2011, in primary healthcare centers with electronic medical records; Data sourc...

  16. Prognosis of Elderly Japanese Patients Aged80 Years Undergoing Hemodialysis

    Directory of Open Access Journals (Sweden)

    Shingo Hatakeyama

    2013-01-01

    Full Text Available Although the number of elderly patients requiring dialysis has increased, data regarding the prognosis of elderly patients undergoing hemodialysis are limited. In the present study, prognosis in Japanese hemodialysis patients aged80 years was evaluated. From January 1988 to July 2013, 1144 consecutive patients with end-stage renal disease required renal replacement therapy at our institution; of these, 141 were aged80 years. These patients’ charts were retrospectively reviewed for relevant clinical variables and survival time. The life expectancies table from the National Vital Statistics database was used, and prognostic factors were assessed by multivariate analysis. In total, 107 deaths (76% were recorded during the study period. The median survival time and estimated life-shortening period in the patients were 2.6 years and −5.3 years, respectively. Eastern Cooperative Oncology Group Performance Status and hemoglobin level were revealed as prognostic factors in the multivariate analysis. Estimates of prognosis and prognostic factors may provide useful information for physicians as well as elderly patients with end-stage kidney disease.

  17. Intravenous thrombolysis with recombinant tissue plasminogen activator for ischemic stroke patients over 80 years old: the Fukuoka Stroke Registry.

    Directory of Open Access Journals (Sweden)

    Ryu Matsuo

    Full Text Available The benefit of intravenous recombinant tissue plasminogen activator (rt-PA therapy for very old patients with acute ischemic stroke remains unclear. The aim of this study was to elucidate the efficacy and safety of intravenous rt-PA therapy for patients over 80 years old.Of 13,521 stroke patients registered in the Fukuoka Stroke Registry in Japan from June 1999 to February 2013, 953 ischemic stroke patients who were over 80 years old, hospitalized within 3 h of onset, and not treated with endovascular therapy were included in this study. Among them, 153 patients were treated with intravenous rt-PA (0.6 mg/kg. For propensity score (PS-matched case-control analysis, 148 patients treated with rt-PA and 148 PS-matched patients without rt-PA therapy were selected by 1:1 matching with propensity for using rt-PA. Clinical outcomes were neurological improvement, good functional outcome at discharge, in-hospital mortality, and hemorrhagic complications (any intracranial hemorrhage [ICH], symptomatic ICH, and gastrointestinal bleeding.In the full cohort of 953 patients, rt-PA use was associated positively with neurological improvement and good functional outcome, and negatively with in-hospital mortality after adjustment for multiple confounding factors. In PS-matched case-control analysis, patients treated with rt-PA were still at lower risk for unfavorable clinical outcomes than non-treated patients (neurological improvement, odds ratio 2.67, 95% confidence interval 1.61-4.40; good functional outcome, odds ratio 2.23, 95% confidence interval 1.16-4.29; in-hospital mortality, odds ratio 0.30, 95% confidence interval 0.13-0.65. There was no significant association between rt-PA use and risk of hemorrhagic complications in the full and PS-matched cohorts.Intravenous rt-PA therapy was associated with improved clinical outcomes without significant increase in risk of hemorrhagic complications in very old patients (aged>80 years with acute ischemic stroke.

  18. Liver Transplantation Outcomes Using Grafts From Donors Older Than the Age of 80 Years.

    Science.gov (United States)

    Rabelo, A V; Alvarez, M J; Méndez, C S M; Villegas, M T; MGraneroa, K; Becerra, A; Dominguez, M; Raya, A M; Exposito, M; Suárez, Y F

    2015-11-01

    We performed a retrospective cohort study between 2002 and 2014 to compare liver transplantation outcomes between recipients of grafts from donors older than and younger than the age of 80 years. Numerical variables were compared with the Student t test when their distribution was normal and the Mann-Whitney test when it was not, whereas categorical variables were compared with Pearson chi-squared test or Fisher test, as appropriate; P organs from donors younger than 80 years of age and 17 with organs from older donors. The 2 recipient groups did not significantly differ in weight, height, gender, body mass index (BMI), CHILD or MELD score, intensive care unit (ICU) or hospital stay, need for intraoperative hemoderivatives, postreperfusion syndrome, biliary or vascular complications, ischemic cholangiopathy, number of repeat surgeries, graft rejection, retransplantation, or survival at 6 months. Although earlier studies considered livers from elderly donors to be suboptimal, our results support the proposition that octogenarian donors can be an excellent source of liver grafts.

  19. ‘‘The baby-boom is over and the ageing shock awaits’’: populist media imagery in news-press representations of population ageing

    Directory of Open Access Journals (Sweden)

    Anna Sofia Lundgren

    2012-03-01

    Full Text Available From an international perspective, media representations of population ageing have been described as apocalyptic in character. In this article, we analyse the way population ageing is represented in three Swedish newspapers: Aftonbladet, Dagens Nyheter and Va¨sterbottens-Kuriren. The aim is to investigate Swedish news-press representations of population ageing and the old age identities that they offer. We conduct qualitative analyses of the articulations between the verbal content and the use of illustrations, metaphorical language, headlines and captions using the concepts offered by discourse theory. The analysis of the material shows that the studied newspapers firmly position population ageing within a wider discourse of political economy and as a threat to the concept of welfare. Growth is promoted as a self-evident means for adjusting to the expected threat. Illustrations and metaphorical language helped to constitute population ageing as a serious, dichotomised (e.g. young vs. old and emotive (e.g. addressing anxiety and ear problem. The analyses also show how the representations of population ageing bear some populist features, and we argue that such features support a de-politicisation of the phenomenon population ageing.

  20. X-ray study of the thermal expansion anisotropy in AgGaS2 and AgInS2 compounds over the temperature range from 80 to 650 K

    International Nuclear Information System (INIS)

    The lattice parameters α and c of the AgGaS2 and AgInS2 compounds are determined as a function of temperature by X-ray diffraction method in the temperature range from 80 to 650 K. The data are used to evaluate the coefficients of thermal expansion, perpendicular (α/sub perpendicular/) and parallel (α/sub parallel/) to the principal axis, and the thermal expansion of the A-C (α/sub AC/) and B-C (α/sub BC/) bonds. It is found that for the two compounds almost over the whole investigated temperature range the coefficients of expansion α/sub parallel/ and α/sub BC/ are negative while the coefficients α/sub perpendicular/ and α/sub AC/ are positive. (auhtor)

  1. Oral health of individuals aged 3-80 years in Jönköping, Sweden, during 40 years (1973-2013). I. Review of findings on oral care habits and knowledge of oral health.

    Science.gov (United States)

    Norderyd, Ola; Kochi, Göran; Papias, Apostolos; Köhler, Alkisti Anastassaki; Helkimo, Anna Nydell; Brahm, Carl-Otto; Lindmark, Ulrika; Lindfors, Ninita; Mattsson, Anna; Rolander, Bo; Ullbro, Christer; Gerdin, Elisabeth Wárnberg; Frisk, Fredrik

    2015-01-01

    The aim of the this study was to present data on oral care habits and knowledge of oral health in 2013, and to compare these data with results from a series of four previous cross-sectional epidemiological studies. All these studies were carried out in the city of Jönköping, Sweden, in 1973, 1983, 1993, 2003, and 2013. The 1973 study constituted a random sample of 1,ooo individuals evenly distributed in the age groups 3, 5, 10, 15, 20, 30, 40, 50, 60, and 70 years. The same age groups with addition of a group of 80-year-olds were included in the 1983, 1993, 2003, and 2013 studies, which comprised 1,104; 1,078; 987; and 1,010 individuals, respectively. A questionnaire about dental care habits and knowledge of oral health was used. The questionnaire contained the same questions in all the five studies, although some had to be slightly modernised during the 40-year period. During the period 1973-2013, a continous increase of individuals in the age group 20-60 years were treated by the Public Dental Service amounting to about 50%. Almost 70% of the 70- and 80-year-olds were treated by private practitioners. In 2013, 10-20% of the individuals in the age groups 30-40 years did not regularly visit neither Public Dental Service nor a private practitioner. The corresponding figures for the individuals 50-80 years old were 4-7%. Similar number of avoidance was reported in the previous studies. In the survey 2013, about 20-30% of the individuals in the age groups 20-50 felt frightened, sick, or ill at ease at the prospect of an appointment with the dentist. These findings were in agreement with the results from the surveys 1973-2003. Among the younger age groups, 0-15 years, a reduction in self-reported "ill at ease" was found in the surveys 2003 and 2013 compared to the previous surveys in this series. In 2013, the knowledge of the etiology of caries was known by about 60% of the individuals which was similar to that reported 1973-2003. Twenty per cent of the individuals

  2. Full-duplex transmission of 256-QAM WiMAX signals over an 80-km long-reach PON

    DEFF Research Database (Denmark)

    Prince, Kamau; Osadchiy, Alexey Vladimirovich; Tafur Monroy, Idelfonso

    2009-01-01

    We present bi-directional transmission of WiMAXcompliant signaling over an 80-km PON, using a single optical wavelength. Colorless, bi-directional transmission of 256-QAM modulation on a 2.4-GHz RF carrier was achieved at 100- Mb/s (downlink) and 64-Mb/s (uplink)....

  3. Sources, Properties, Aging, and Anthropogenic Influences on OA and SOA over the Southeast US and the Amazon duing SOAS, DC3, SEAC4RS, and GoAmazon

    Science.gov (United States)

    The SE US and the Amazon have large sources of biogenic VOCs, varying anthropogenic pollution impacts, and often poor organic aerosol (OA) model performance. Recent results on the sources, properties, aging, and impact of anthropogenic pollution on OA and secondary OA (SOA) over ...

  4. Experimental investigation of 100-Gbps transmission over 80-km single mode fiber using discrete multi-tone modulation

    Science.gov (United States)

    Tanaka, Toshiki; Nishihara, Masato; Takahara, Tomoo; Li, Lei; Tao, Zhenning; Rasmussen, Jens C.

    2012-12-01

    We experimentally evaluated the transmission performance of discrete multi-tone (DMT) modulation at wavelengths in the 1300-nm and 1550-nm regions and analyzed the degradation factors. By using their countermeasures to extend transmission distance, we realized the capacity of 100 Gbps with 2WDM x 50 Gbps over 80 km. To our knowledge, this work is the highest capacity in 80-km transmission system using direct modulation and direct detection. These results show that the DMT modulation can be used to realize high capacity transceiver with simple and cost effective configuration for the bi-directional transmission system like a passive optical network.

  5. The effect of range of motion exercises on delirium prevention among patients aged 65 and over in intensive care units.

    Science.gov (United States)

    Karadas, Canan; Ozdemir, Leyla

    2016-01-01

    The purpose of this study was to determine the effect of range of motion exercises on preventing delirium and shortening the duration of delirium among patients in the intensive care unit who are aged 65 and over. The study was conducted in the intensive care unit on patients with non-invasive mechanical ventilation. The sample size included 47 patients from the intervention group and 47 from the control group. The incidence of delirium was 8.5% in the intervention group and 21.3% in the control group. The duration of delirium was 15 h for patients in the intervention group and 38 h for those in the control group. Although delirium incidence and duration decreased by 2.5-fold in the intervention group compared to the control group; there was no significant relationship between the intervention and control groups. In conclusion, as the decreases in delirium occurrence and duration were not statistically significant, the effect of range of motion exercises was limited. PMID:26763172

  6. [MSDs and job security of employees aged 50 years and over: a challenge for occupational health and public health].

    Science.gov (United States)

    Chiron, Elise; Roquelaure, Yves; Ha, Catherine; Touranchet, Annie; Chotard, Anne; Bidron, Patrick; Ledenvic, Béatrice; Leroux, François; Mazoyer, Annick; Goldberg, Marcel; Imbernon, Ellen

    2008-01-01

    Work-related musculoskeletal disorders of the upper limbs (MSDs) are the first cause of occupational illness in France, as in Europe. A pilot network for epidemiological surveillance system of MSDs has been implemented in France's Loire Valley region to assess the prevalence of MSDs and their risk factors in the working population, namely the ageing workforce. The surveillance was based on a network of occupational physicians and used the recommendations of a group of European experts ('Saltsa Criteria document' consensus). Between 2002 and 2004, 3710 men and women (aged 20-59) representative of the regional workforce were randomly selected. Exposure to risk factors of MSDs was evaluated by the use of a self-administered questionnaire which aimed to assess bio-mechanical and psychosocial risk factors. With at least one of the six primary MSDs of the upper limbs having been clinically diagnosed using a rigorous protocol, the prevalence of clinically-diagnosed MSDs was high: about 11% of male and 15% of female workers suffered from at least one of the MSDs studied. After age fifty, about 19% of male and 27% of female workers suffered from at least one MSD and 4% of male and 6% of female workers from at least two disorders. Blue-collar workers were the most affected, regardless of age or gender, followed by office employees. Exposure to MSD risk factors of remained high after age fifty: 77% of male and 72% of female blue-collar workers were exposed to at least two MSD risk factors. The implications for the prevention of MSDs and job security of workers are discussed. The high prevalence of specific MSDs of the upper limb combined with a high exposure to risk factors of MSDs in ageing workers emphasizes the need to implement comprehensive prevention programs in most sectors to reduce the exposure to risk, the prevalence of MSDs and ensure the capacity to keep employees suffering from MSDs working, or at least to quickly return to work after recovery. PMID:18773826

  7. Potential drug-drug and drug-disease interactions in prescriptions for ambulatory patients over 50 years of age in family medicine clinics in Mexico City

    Directory of Open Access Journals (Sweden)

    Torres-Arreola Laura del Pilar

    2007-09-01

    Full Text Available Abstract Background In Mexico, inappropriate prescription of drugs with potential interactions causing serious risks to patient health has been little studied. Work in this area has focused mainly on hospitalized patients, with only specific drug combinations analyzed; moreover, the studies have not produced conclusive results. In the present study, we determined the frequency of potential drug-drug and drug-disease interactions in prescriptions for ambulatory patients over 50 years of age, who used Mexican Institute of Social Security (IMSS family medicine clinics. In addition, we aimed to identify the associated factors for these interactions. Methods We collected information on general patient characteristics, medical histories, and medication (complete data. The study included 624 ambulatory patients over 50 years of age, with non-malignant pain syndrome, who made ambulatory visits to two IMSS family medicine clinics in Mexico City. The patients received 7-day prescriptions for non-opioid analgesics. The potential interactions were identified by using the Thompson Micromedex program. Data were analyzed using descriptive, bivariate and multiple logistic regression analyses. Results The average number of prescribed drugs was 5.9 ± 2.5. About 80.0% of patients had prescriptions implying one or more potential drug-drug interactions and 3.8% of patients were prescribed drug combinations with interactions that should be avoided. Also, 64.0% of patients had prescriptions implying one or more potential drug disease interactions. The factors significantly associated with having one or more potential interactions included: taking 5 or more medicines (adjusted Odds Ratio (OR: 4.34, 95%CI: 2.76–6.83, patient age 60 years or older (adjusted OR: 1.66, 95% CI: 1.01–2.74 and suffering from cardiovascular diseases (adjusted OR: 7.26, 95% CI: 4.61–11.44. Conclusion The high frequency of prescription of drugs with potential drug interactions showed in

  8. An observational study of comorbidity and healthcare utilisation among HIV-positive patients aged 50 years and over.

    Science.gov (United States)

    Patel, Roshani; Moore, Thomas; Cooper, Vanessa; McArdle, Conor; Perry, Nicky; Cheek, Elizabeth; Gainsborough, Nicola; Fisher, Martin

    2016-07-01

    The number of HIV-positive people aged ≥50 years is rising each year. We measured the prevalence of non-infectious illnesses and their risk factors and described healthcare use in this UK population. A cross-sectional, observational study was conducted at an outpatient HIV specialist clinic in south east England. Patients age ≥50 years were invited to complete questionnaires measuring demographics, non-infectious illnesses, medication use, lifestyle and healthcare utilisation. The response rate was 67%. Of 299 participants, 84% reported ≥1 comorbid condition and 61% reported ≥2 (multimorbidity). Most commonly reported were high cholesterol, sexual dysfunction, hypertension and depression. In multivariate analyses, age, number of years HIV-positive and duration of antiretroviral therapy remained significant predictors of comorbidity when controlling for lifestyle factors (exercise, smoking and use of recreational drugs and alcohol). Use of non-HIV healthcare services was associated with increasing comorbidity, a longer duration of HIV and recreational drug use. The majority of HIV-patients aged ≥50 years reported multiple comorbidities and this was associated with polypharmacy and increased use of non-HIV services. Further research examining the quality, safety and patient experience of healthcare is needed to inform development of services to optimally meet the needs of older HIV-positive patients. PMID:26068965

  9. Association of obesity with socioeconomic status among adults of ages 18 to 80 years in rural Northwest China

    OpenAIRE

    Pei, Leilei; Cheng, Yue; Kang, Yijun; Yuan, Shuyi; Yan, Hong

    2015-01-01

    Background Understanding social disparities in obesity are presently an essential element in establishing public health priorities. However, the association between socioeconomic status (SES) and obesity has not been assessed in rural Northwest China. This study aims to explore the effect of SES on overweight/obesity and abdominal obesity by gender and age in rural Northwest China. Methods A total of 3030 participants between the ages of 18 to 80 years from rural Hanzhong, Shaanxi province, N...

  10. Assessment of normal left atrial appendage anatomy and function over gender and ages by dynamic cardiac CT

    International Nuclear Information System (INIS)

    The aim of this study was to evaluate variations in anatomy and function according to age and gender using cardiac computed tomography (CT) in a large prospective cohort of healthy patients. The left atrial appendage (LAA) is considered the most frequent site of intracardiac thrombus formation. However, variations in normal in vivo anatomy and function according to age and gender remain largely unknown. Three-dimensional (3D) cardiac reconstructions of the LAA were performed from CT scans of 193 consecutive patients. Parameters measured included LAA number of lobes, anatomical position of the LAA tip, angulation measured between the proximal and distal portions, minimum (iVolmin) and maximum (iVolmax) volumes indexed to body surface area (BSA), and ejection fraction (LAAEF). Relationship with age was assessed for each parameter. We found that men had longer and wider LAAs. The iVolmin and iVolmax increased by 0.23 and 0.19 ml per decade, respectively, while LAAEF decreased by 2 % per decade in both sexes. Although LAA volumes increase, LAAEF decreases with age in both sexes. (orig.)

  11. Assessment of normal left atrial appendage anatomy and function over gender and ages by dynamic cardiac CT

    Energy Technology Data Exchange (ETDEWEB)

    Boucebci, Samy; Velasco, Stephane; Duboe, Pier-Olivier; Tasu, Jean-Pierre [University of Poitiers, University Hospital, Department of Radiology, Poitiers (France); Pambrun, Thomas [University of Poitiers, University Hospital, Department of Cardiology, Poitiers (France); Ingrand, Pierre [University of Poitiers, University Institute of Public Health, Poitiers (France)

    2016-05-15

    The aim of this study was to evaluate variations in anatomy and function according to age and gender using cardiac computed tomography (CT) in a large prospective cohort of healthy patients. The left atrial appendage (LAA) is considered the most frequent site of intracardiac thrombus formation. However, variations in normal in vivo anatomy and function according to age and gender remain largely unknown. Three-dimensional (3D) cardiac reconstructions of the LAA were performed from CT scans of 193 consecutive patients. Parameters measured included LAA number of lobes, anatomical position of the LAA tip, angulation measured between the proximal and distal portions, minimum (iVol{sub min}) and maximum (iVol{sub max}) volumes indexed to body surface area (BSA), and ejection fraction (LAAEF). Relationship with age was assessed for each parameter. We found that men had longer and wider LAAs. The iVol{sub min} and iVol{sub max} increased by 0.23 and 0.19 ml per decade, respectively, while LAAEF decreased by 2 % per decade in both sexes. Although LAA volumes increase, LAAEF decreases with age in both sexes. (orig.)

  12. Reference equations for lung function screening of healthy never-smoking adults aged 18-80 years

    OpenAIRE

    Kuster, S P; Kuster, D; Schindler, C.; Rochat, M K; Braun, J; Held, L.; Brändli, O

    2008-01-01

    The need for updated spirometric reference values to be used on European populations is widely acknowledged, especially for subjects aged >70 yrs. Their reference values are generally based on extrapolations. The aim of the present study was to calculate reference values for lung function screening of healthy, never-smoking adults aged 18-80 yrs and to compare them with the most widely used reference equations. Results of screening spirometry of 8,684 healthy, never-smoking adults were used t...

  13. 47 CFR 17.10 - Antenna structures over 304.80 meters (1,000 feet) in height.

    Science.gov (United States)

    2010-10-01

    ... feet) in height. 17.10 Section 17.10 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL... § 17.10 Antenna structures over 304.80 meters (1,000 feet) in height. Where one or more antenna farm... of an existing station proposing the erection of an antenna structure over 304.80 meters (1,000...

  14. [Is the age of causality over?].

    Science.gov (United States)

    Antes, Gerd

    2016-01-01

    For the assessment of diagnostic and therapeutic interventions a sound scientific base has been developed during the last twenty years. Under the headline of Evidence-based Medicine nowadays a comprehensive set of tools is offered which can be used to assess the benefit and the risk of medical interventions. The overarching rule which evolved for the grading of evidence from studies is to maximize the protection against bias. Despite this coherent approach, there is still controversy that is regularly mainly sparked by the dominant position of randomized controlled trials. Observational studies and registries are deemed to be more relevant because they provide results that are produced under "everyday conditions". These controversial discussions often show a lack of orientation, as they do without the explicit naming of scientific criteria for the evaluation and to a large extent rely on common sense. That the latter may not be a good guide for assessments in the medical field is known from numerous studies. For unbiased assessments the rigorous use of basic scientific principles is the only way. To express doubt and question these principles requires a scientific basis itself. The alternative is to move away from the established scientific foundation. The path to a "new" scientific paradigm is currently dominated by a discussion under the buzzword Big Data. Defined by the three V's of Variety, Velocity and Volume, a potential of the unlimited analysis of data is envisioned, for which there is currently no validation and whose logical foundations are extremely doubtful. The demand must be reaffirmed that instead of promises strict validation criteria be followed for the evaluation of all interventions in medicine, particularly in view of these developments. PMID:27320023

  15. [Is the age of causality over?].

    Science.gov (United States)

    Antes, Gerd

    2016-01-01

    For the assessment of diagnostic and therapeutic interventions a sound scientific base has been developed during the last twenty years. Under the headline of Evidence-based Medicine nowadays a comprehensive set of tools is offered which can be used to assess the benefit and the risk of medical interventions. The overarching rule which evolved for the grading of evidence from studies is to maximize the protection against bias. Despite this coherent approach, there is still controversy that is regularly mainly sparked by the dominant position of randomized controlled trials. Observational studies and registries are deemed to be more relevant because they provide results that are produced under "everyday conditions". These controversial discussions often show a lack of orientation, as they do without the explicit naming of scientific criteria for the evaluation and to a large extent rely on common sense. That the latter may not be a good guide for assessments in the medical field is known from numerous studies. For unbiased assessments the rigorous use of basic scientific principles is the only way. To express doubt and question these principles requires a scientific basis itself. The alternative is to move away from the established scientific foundation. The path to a "new" scientific paradigm is currently dominated by a discussion under the buzzword Big Data. Defined by the three V's of Variety, Velocity and Volume, a potential of the unlimited analysis of data is envisioned, for which there is currently no validation and whose logical foundations are extremely doubtful. The demand must be reaffirmed that instead of promises strict validation criteria be followed for the evaluation of all interventions in medicine, particularly in view of these developments.

  16. Ventilation function changes in patients with Duchenne muscular dystrophy under and over 12 years of age Analysis of 65 cases

    Institute of Scientific and Technical Information of China (English)

    Zhiping Li; Yifeng Luo; Jianqiang Huang; Lihong Peng; Xiaoli Yao

    2008-01-01

    BACKGROUND: Previous studies indicate that vital capacity in patients with Duchenne muscular dystrophy increases with age when they are under 12 years old, and decreases from 13 or 14 years of age;however, recent studies indicate that the vital capacity in patients with Duchenne muscular dystrophy begins to decrease even before 12 years of age.OBJECTIVE: To verify if the vital capacity in patients with Duchenne muscular dystrophy decreases before the age of 12 years and to observe the effect of rehabilitation exercise on vital capacity.DESIGN, TIME AND SETTING: The case analysis was performed at the Department of Neurology,The First Affiliated Hospital of Sun Yat-Sen University (Guangzhou, Guangdong Province, China) from December 2004 to January 2006.PARTICIPANTS: Sixty-five male patients diagnosed as having Duchenne muscular dystrophy and who underwent pulmonary ventilation function examination at the Department of Neurology, The First Affiliated Hospital of Sun Yat-Sen University (Guangzhou, Guangdong Province, China) from December 2004 to January 2006; ages ranged from 6 to 22 years old.METHODS: The ventilation function of 65 patients was determined using a Sensor Medics 2100pulmonary function test apparatus (USA), and the data obtained were subjected to statistical analysis comparing patients under 12 years of age and those above 13 years of age, and comparing those who performed rehabilitation exercise with those who did not.MAIN OUTCOME MEASURES: Forced vital capacity (FVC); forced expiratory volume in one second (FEV1); maximal voluntary ventilation (MMV); the ratio of forced expiratory volume in one second and forced vital capacity (FEV1/FVC); each measured value as a percentage of the corresponding predicted value.RESULTS: There were no significant differences in FVC, FEV1 and MMV between patients under 12 years of age and those above 13 years of age (P > 0.05). The FVC, FEV1 and MMV values, as percentages of the predicted values, were, in patients under

  17. Oral health of individuals aged 3-80 years in Jönköping, Sweden during 30 years (1973-2003). I. Review of findings on dental care habits and knowledge of oral health.

    Science.gov (United States)

    Hugoson, Anders; Koch, Göran; Göthberg, Catharina; Helkimo, Anna Nydell; Lundin, Sven-Ake; Norderyd, Ola; Sjödin, Bengt; Sondell, Katarina

    2005-01-01

    The aim of the present study was to compare data on dental care habits and knowledge of oral health in four cross-sectional epidemiological studies carried out in 1973,1983,1993, and 2003. The 1973 study constituted a random sample of 1,000 individuals evenly distributed in the age groups 3, 5, 10, 15, 20, 30, 40, 50, 60, and 70 years. The same age groups with addition of a group of 80-year-olds were included in the 1983, 1993 and 2003 studies, which comprised 1,104, 1,078, and 987 individuals, respectively. A questionnaire about dental care habits and knowledge of oral health was used in connection with a clinical and radiographic examination. The same questions were used in all the four studies. An addition to the 1993 and 2003 investigations were questions concerning ethnic background. In 2003 approximately 90-95 per cent of all individuals were visiting the dentist on a regular basis every or every second year. The 30- and 40-yea r-olds, however, did not visit a dentist as regularly in 2003 as in 1993. In these age groups 21-24 per cent of the individuals, respectively, reported that they had not visited a dentist in the last 2 years. Almost all children 3-15 years old received their dental care within the Public Dental Service (PDS). During the period 1973-2003 an increase in percentage of individuals aged 20-50 years treated by the PDS was seen compared to private practice, while among 60-80 year-olds there were only minor changes. Most so-year-olds and older received their dental care by private practitioners. About 70-80 per cent of all adults in 2003 were enrolled in a recall system on the dentist's initiative while in 1973 most appointments were based on the patient's own initiative. The number of individuals who were frightened, 5-17 per cent, or felt discomfort at the prospect of an appointment with the dentist was more or less the same during the whole period. The knowledge of the etiology of dental diseases did not changed much between 1973 and 2003

  18. What's Black and White and Re-Tweeted All Over? Teaching News Literacy in the Digital Age

    Science.gov (United States)

    Loth, Renee

    2012-01-01

    In 2007 the John S. and James L. Knight Foundation placed a major bet on State University of New York at Stony Brook: $1.7-million to enroll 10,000 students in its news-literacy curriculum over five years. Alberto Ibarguen, president and chief executive of the foundation, expected the course to foster "a group of students who would simply graduate…

  19. Aging and Aged in Organized Crime.

    Science.gov (United States)

    Amir, Menachem

    1989-01-01

    Examines problems of the aged in organized crime, basing discussion on organized crime bosses over age 60 operating in Italy, the United States, and Israel. Looks at problems stemming from normative system in organized crime, role of the aged, intergenerational problems, fears of the aged, excuses and justifications, standards of life, and…

  20. Application of therapeutic ERCP in patients 80 years of age and older%高龄患者进行治疗性逆行胆管造影的经验体会

    Institute of Scientific and Technical Information of China (English)

    邵晓冬; 郭晓钟; 任丽楠; 赵佳均; 梁振东; 林浩

    2013-01-01

    Objective To evaluate the efficacy and the safety of therapeutic ERCP in patients 80 years of age and older with biliary and pancreatic diseases. Methods Patients with biliary and pancreatic diseases treated with therapeutic ERCP in our hospital from December 2005 to December 2011 were retrospectively reviewed. Results Two hundred and thirty seven patients underwent 268 therapeutic ERCP procedures. The indications included choledocholithiasis( 53. 2% ), malignant obstructive jaundice( 20. 2% ), biliary pancreatitis ( 10. 5% ),acute suppurative cholangitis( 9. 7% ),benign biliary stricture( 3. 4% )and others( 3. 0% ). The success rate of therapeutic ERCP was 94. 9% and 14. 6% of all procedures were emergent. Bile duct stones were completely cleared in 95. 4% of patients with cho-ledocholithiasis. Four patients underwent ERBD and two patients were referred for surgical intervention due to unsuccessful clearance of bile duct stone. Metal biliary stents were inserted in 23 patients with malignant obstructive jaundice. Plastic biliary stents were inserted in 34 patients,of which 11 patients underwent stent replacement because of stent occlustion. Unsuccessful ERCP procedures occurred in 12 cases. There were 183( 77. 2% )patients with peripapillary diverticulum. Complications occurred in 6 patients including cholangitis( 2 cases ), pancreatitis( 1 case ), hemorrhage( 2 cases )and perforation( 1 case )and there was no death case in the group. Conclusion For patients 80 years of age and older with biliary and pancreatic diseases, therapeutic ERCP is an effective and safe treatment.%目的 评估在80岁以上高龄患者中经逆行胆管造影(ERCP)进行胆胰疾病治疗的疗效和安全性.方法 回顾性分析该院自2005年12月-2011年12月经ERCP进行胆胰疾病治疗的80岁以上高龄患者的病历资料.结果 237例80岁以上高龄患者共进行了268例次治疗性ERCP.患者行ERCP治疗的原因有:胆管结石(53.2%)、恶性梗阻性黄疸(20.2%)

  1. The impact of seed predation and browsing on natural sessile oak regeneration under different light conditions in an over-aged coppice stand

    OpenAIRE

    Kamler J; Dobrovolný L; Drimaj J; Kadavý J; Kneifl M; Adamec Z; Knott R; Martiník A; Plhal R; Zeman J; Hrbek J

    2016-01-01

    Sessile oak (Quercus petraea (Matt.) Liebl.) is one of the most important commercial species cultivated at low altitudes in the Czech Republic, and over-aged coppices are a significant part of oak stands in the region. In order to secure a high-valuable timber production (e.g., through conversion of such stands into coppices-with-standards), knowledge of the potential and limits of generative regeneration is essential. This study was conducted in three oak-dominated over-aged coppice stands i...

  2. Changes in bronchial responsiveness to inhaled histamine over four years in middle aged male smokers and ex-smokers.

    OpenAIRE

    Lim, T K; Taylor, R. G.; WATSON, A.; Joyce, H; Pride, N. B.

    1988-01-01

    Bronchial hyperresponsiveness to inhaled histamine in smokers is associated with an accelerated annual decline in FEV1 and low baseline FEV1 values. The evolution of bronchial hyperresponsiveness and whether it precedes or follows the accelerated decline in FEV1 and reduction in FEV1 is unknown. Measurements of the provocative concentration of inhaled histamine required to reduce FEV1 by 20% (PC20) were repeated after a four year interval in 27 male smokers (mean age 59 years, smoking on aver...

  3. Prevalence of Cognitive Impairment and Depression among a Population Aged over 60 Years in the Metropolitan Area of Guadalajara, Mexico

    OpenAIRE

    Ortiz, Genaro G.; Arias-Merino, Elva D.; Flores-Saiffe, María E.; Velázquez-Brizuela, Irma E.; Macías-Islas, Miguel A.; Fermín P. Pacheco-Moisés

    2012-01-01

    Background. Cognitive impairment is an important clinical issue among elderly patients with depression and has a more complex etiology because of the variable rate of neurodegenerative changes associated with depression. The aim of the present work was to examine the prevalence of cognitive impairment and depression in a representative sample of adults aged ≥60 years. Methods. The presented work was a cross-sectional study on the prevalence of cognitive impairment and depression. Door-to-doo...

  4. The controversy over the association between statins use and progression of age-related macular degeneration: a mini review

    Directory of Open Access Journals (Sweden)

    Vasileios Peponis

    2010-07-01

    Full Text Available Vasileios Peponis1, Spyridon E Chalkiadakis1, Stefanos Bonovas2,3, Nikolaos M Sitaras21Athens Eye Hospital, 2nd Eye Clinic, Athens, Greece; 2Department of Pharmacology, School of Medicine, University of Athens, Greece; 3Center for Diseases Control and Prevention, Athens, GreeceObjective: Age-related macular degeneration (AMD is the leading cause of blindness in ¬western societies. Statins comprise a class of pharmacological agents that reduce plasma cholesterol levels, and have been shown to prevent progression of atherosclerosis and reduce cardiovascular mortality. The relationship between these medications and AMD has been evaluated in several recent studies. Herein, we examine the current evidence for an association between statin use and risk of AMD.Methods: Literature database search (Medline, Scopus, and Science Citation Index Expanded for articles published up to March 2010, using particular search terms.Results: From the current evidence available, it is not safe to conclude upon the assumption of a protective effect of statins against age-related maculopathy and AMD.Conclusion: There is a need for large scale prospective studies with a long follow-up period and accurate assessment of AMD to further explore this matter.Keywords: age-related macular degeneration (AMD, blindness, statin use, controversy

  5. Long distance bicycle riding causes prostate-specific antigen to increase in men aged 50 years and over.

    Directory of Open Access Journals (Sweden)

    Sandra L Mejak

    Full Text Available OBJECTIVES: To investigate whether bicycle riding alters total prostate-specific antigen (tPSA serum concentrations in healthy older men. METHODS: 129 male participants, ranging in age from 50 to 71 years (mean 55 years, rode in a recreational group bicycle ride of between 55 and 160 kilometers. Blood samples for tPSA analysis were drawn within 60 minutes before starting, and within 5 minutes after completing the ride. The pre-cycling and post-cycling tPSA values were log transformed for normality and compared using paired t-tests. Linear regression was used to assess the relationship between changes in tPSA with age and distance cycled. RESULTS: Bicycle riding caused tPSA to increase by an average of 9.5% (95% CI = 6.1-12.9; p<0.001 or 0.23 ng/ml. The number of participants with an elevated tPSA (using the standard PSA normal range cut-off of 4.0 ng/ml increased from two pre-cycle to six post-cycle (or from five to eight when using age-based normal ranges. Univariate linear regression analysis revealed that the change in tPSA was positively correlated with age and the distance cycled. CONCLUSIONS: Cycling causes an average 9.5% increase in tPSA, in healthy male cyclists ≥50 years old, when measured within 5 minutes post cycling. We considered the increase clinically significant as the number of participants with an elevated PSA, according to established cut-offs, increased post-ride. Based on the research published to date, the authors suggest a 24-48 hour period of abstinence from cycling and ejaculation before a PSA test, to avoid spurious results.

  6. Long Distance Bicycle Riding Causes Prostate-Specific Antigen to Increase in Men Aged 50 Years and Over

    Science.gov (United States)

    Mejak, Sandra L.; Bayliss, Julianne; Hanks, Shayne D.

    2013-01-01

    Objectives To investigate whether bicycle riding alters total prostate-specific antigen (tPSA) serum concentrations in healthy older men. Methods 129 male participants, ranging in age from 50 to 71 years (mean 55 years), rode in a recreational group bicycle ride of between 55 and 160 kilometers. Blood samples for tPSA analysis were drawn within 60 minutes before starting, and within 5 minutes after completing the ride. The pre-cycling and post-cycling tPSA values were log transformed for normality and compared using paired t-tests. Linear regression was used to assess the relationship between changes in tPSA with age and distance cycled. Results Bicycle riding caused tPSA to increase by an average of 9.5% (95% CI = 6.1–12.9; p<0.001) or 0.23 ng/ml. The number of participants with an elevated tPSA (using the standard PSA normal range cut-off of 4.0 ng/ml) increased from two pre-cycle to six post-cycle (or from five to eight when using age-based normal ranges). Univariate linear regression analysis revealed that the change in tPSA was positively correlated with age and the distance cycled. Conclusions Cycling causes an average 9.5% increase in tPSA, in healthy male cyclists ≥50 years old, when measured within 5 minutes post cycling. We considered the increase clinically significant as the number of participants with an elevated PSA, according to established cut-offs, increased post-ride. Based on the research published to date, the authors suggest a 24–48 hour period of abstinence from cycling and ejaculation before a PSA test, to avoid spurious results. PMID:23418500

  7. Evaluation of Concordance between Hip and Spine T Scores in the Diagnosis of Osteoporosis in Men Over Age of Fifty

    Directory of Open Access Journals (Sweden)

    Oya Özdemir

    2015-12-01

    Full Text Available Objective: The aim of this study was to evaluate the concordance in diagnosis of osteoporosis based on the World Health Organization (WHO classification of bone mineral density (BMD measurements of hip and spine in men aged ≥50 years. Materials and Methods: The BMD measurements, which were measured via dual x-ray energy absorptiometry (DXA, of 10.049 patients admitted to our hospital between January 1, 2012 and August 1, 2013 were retrospectively reviewed and 649 men aged ≥50 years were included in the study. It was defined as minor discordance when the difference between two sites was no more than one WHO diagnostic class. Major discordance was present when one site is osteoporotic and the other is normal. Results: The mean age of the participants was 68.7±9.1 (50-93 years. The mean values of lumbar spine and total hip BMD values were 1.1681±0.231 (0.629-2.267 g/cm2 and 0.933±0.152 (0.414-1.444 g/cm2, respectively. According to L1-L4 vertebra T score, 54.4% of the individuals were classified as normal, 33% were osteopenic, and 12.6% were osteoporotic. Whereas, according to total femur T score 41.7% of participants were normal, 47.5% had osteopenia, and 10.8% had osteoporosis. Concordance of T scores, minor discordance, and major discordance were seen in 59.6%, 37.6%, and 2.8% of the patients, respectively. Conclusion: In this study, it was shown that in 4 of every 10 male patients aged ≥50 years tested by DXA, T score discordance between spine and total hip measurement sites is present. This ratio is similar to the results of previous studies investigating the prevalence of this phenomenon in larger samples including both postmenopausal women and men. Clinicians should keep in their mind that T score discordance is a prevalent finding and can be related to various physiological and pathological patient factors as well as the performance or analysis of DXA itself.

  8. Corrosion of Artificial Aged Magnesium Alloy AZ80 in 3.5 wt pct NaCl Solutions

    Institute of Scientific and Technical Information of China (English)

    Rongchang ZENG; Enhou HAN; Wei KE

    2007-01-01

    The corrosion morphologies of aged magnesium alloy AZ80 were investigated by immersion corrosion tests,scanning electron microscopy (SEM), electrochemical measurement. The T5 heat treatment was carried out in a vacuum furnace, holding for 16 h at 177℃, and then cooling in air. The results showed intergranular corrosion (IGC) occurred as an aged AZ80 sample was immersed in 3.5 wt pct NaCl aqueous solution for 1 h and the narrow path attack progressed predominantly along the bulk β phase in the grain boundaries or took place in the eutectic areas. IGC was attributed to the network distribution of β phase along the grain boundaries, the depleted aluminium in the precipitation areas and the breakdown potential.

  9. Prevalence of Cognitive Impairment and Depression among a Population Aged over 60 Years in the Metropolitan Area of Guadalajara, Mexico.

    Science.gov (United States)

    Ortiz, Genaro G; Arias-Merino, Elva D; Flores-Saiffe, María E; Velázquez-Brizuela, Irma E; Macías-Islas, Miguel A; Pacheco-Moisés, Fermín P

    2012-01-01

    Background. Cognitive impairment is an important clinical issue among elderly patients with depression and has a more complex etiology because of the variable rate of neurodegenerative changes associated with depression. The aim of the present work was to examine the prevalence of cognitive impairment and depression in a representative sample of adults aged ≥60 years. Methods. The presented work was a cross-sectional study on the prevalence of cognitive impairment and depression. Door-to-door interview technique was assigned in condition with multistage probability random sampling to obtain subjects that represent a population of the Guadalajara metropolitan area (GMA), Mexico. Cognitive function and depression were assessed by applying standardized Mini-Mental State Examination of Folstein (MMSE) and the Geriatric Depression Scale (GDS), respectively. Results. Prevalence of cognitive impairment was 13.8% (14.5% women, 12.6% men); no significant differences by gender and retired or pensioner were found. Prevalence of depression was 29.1% (33.6% women, 21.1% men); no significant differences by retired or pensioner were found. Cognitive impairment was associated with depression (OR  =  3.26, CI 95%, 2.31-4.60). Prevalence of cognitive impairment and depression is associated with: being woman, only in depression being older than 75 years being married, and a low level of education. Conclusion. Cognitive impairment and depression are highly correlated in adults aged ≥60.

  10. Prevalence of Cognitive Impairment and Depression among a Population Aged over 60 Years in the Metropolitan Area of Guadalajara, Mexico

    Directory of Open Access Journals (Sweden)

    Genaro G. Ortiz

    2012-01-01

    Full Text Available Background. Cognitive impairment is an important clinical issue among elderly patients with depression and has a more complex etiology because of the variable rate of neurodegenerative changes associated with depression. The aim of the present work was to examine the prevalence of cognitive impairment and depression in a representative sample of adults aged ≥60 years. Methods. The presented work was a cross-sectional study on the prevalence of cognitive impairment and depression. Door-to-door interview technique was assigned in condition with multistage probability random sampling to obtain subjects that represent a population of the Guadalajara metropolitan area (GMA, Mexico. Cognitive function and depression were assessed by applying standardized Mini-Mental State Examination of Folstein (MMSE and the Geriatric Depression Scale (GDS, respectively. Results. Prevalence of cognitive impairment was 13.8% (14.5% women, 12.6% men; no significant differences by gender and retired or pensioner were found. Prevalence of depression was 29.1% (33.6% women, 21.1% men; no significant differences by retired or pensioner were found. Cognitive impairment was associated with depression (OR  =  3.26, CI 95%, 2.31–4.60. Prevalence of cognitive impairment and depression is associated with: being woman, only in depression being older than 75 years being married, and a low level of education. Conclusion. Cognitive impairment and depression are highly correlated in adults aged ≥60.

  11. Chronic conditions and sleep problems among adults aged 50 years or over in nine countries: a multi-country study.

    Directory of Open Access Journals (Sweden)

    Ai Koyanagi

    Full Text Available Data on the association between chronic conditions or the number of chronic conditions and sleep problems in low- or middle-income countries is scarce, and global comparisons of these associations with high-income countries have not been conducted.Data on 42116 individuals 50 years and older from nationally-representative samples of the Collaborative Research on Ageing in Europe (Finland, Poland, Spain and the World Health Organization's Study on Global Ageing and Adult Health (China, Ghana, India, Mexico, Russia, South Africa conducted between 2011-2012 and 2007-2010 respectively were analyzed.The association between nine chronic conditions (angina, arthritis, asthma, chronic lung disease, depression, diabetes, hypertension, obesity, and stroke and self-reported severe/extreme sleep problems in the past 30 days was estimated by logistic regression with multiple variables. The age-adjusted prevalence of sleep problems ranged from 2.8% (China to 17.0% (Poland. After adjustment for confounders, angina (OR 1.75-2.78, arthritis (OR 1.39-2.46, and depression (OR 1.75-5.12 were significantly associated with sleep problems in the majority or all of the countries. Sleep problems were also significantly associated with: asthma in Finland, Spain, and India; chronic lung disease in Poland, Spain, Ghana, and South Africa; diabetes in India; and stroke in China, Ghana, and India. A linear dose-dependent relationship between the number of chronic conditions and sleep problems was observed in all countries. Compared to no chronic conditions, the OR (95%CI for 1,2,3, and ≥ 4 chronic conditions was 1.41 (1.09-1.82, 2.55 (1.99-3.27, 3.22 (2.52-4.11, and 7.62 (5.88-9.87 respectively in the overall sample.Identifying co-existing sleep problems among patients with chronic conditions and treating them simultaneously may lead to better treatment outcome. Clinicians should be aware of the high risk for sleep problems among patients with multimorbidity. Future studies

  12. Smoking and Alzheimer's disease among Mongolian and Han Chinese aged 55 years and over living in the Inner Mongolia farming area of China

    Institute of Scientific and Technical Information of China (English)

    Chunyu Zhang; Lin Da; Shigang Zhao; Desheng Wang; Guangming Niu; Huriletemuer

    2012-01-01

    Residents aged 55 years or older from 27 communities and two settlements in Xilingol League of Inner Mongolia were selected for participation in an Alzheimer's disease epidemiological investigation from June 2008 to June 2009, including 3 259 Mongolians and 5 887 Han Chinese.The Mongolian subjects in the Alzheimer's disease group were at age of 55 years or older (on average), and more of them were male, illiterate and/or had a history of coronary artery disease and/or diabetes compared with the Mongolian subjects in the non-Alzheimer's disease group. The Han Chinese subjects in the Alzheimer's disease group were at age of 55 years or older (on average) and more of them were women, illiterate and/or had a history of coronary artery disease,and less of them had a history of alcohol consumption compared with the non-Alzheimer's disease group. Non-conditional multivariate stepwise logistic regression identified that male gender,increasing age and having a history of diabetes and/or coronary heart disease were associated with higher odds of Alzheimer's disease among Mongolians while having an educational background was associated with lower odds (OR = 0.259, 95%CI 0.174-0.386). Among the Han Chinese subjects, male gender, increasing age and having a history of coronary heart disease and/or hypertension was associated with higher odds of Alzheimer's disease, while having an educational background was associated lower odds (OR = 0.271, 95%CI 0.192-0.381). The results also indicated that extremely heavy smoking may be a risk factor for Alzheimer's disease in Mongolian males aged over 55 years. There was no significant difference in smoking habits between the Mongolian and Han Chinese subjects with Alzheimer's disease.

  13. Relationship between exercise and bone mineral density among over 5,000 women aged 40 years and above.

    Science.gov (United States)

    Kano, K

    1998-03-01

    An epidemiological survey was conducted to clarify the relationship between bone mineral density(BMD) and exercise at 14 health centers in Ibaraki Prefecture, Japan from September 1994 through March 1995. More than 5,000 women participated in this survey. Second metacarpal BMD was measured by CXD(Computed X-ray Densitometry) method. Information about past history of exercise was obtained by questionnaire. sigma GS/D game, foot sports and gymnastics were the main exercises. When osteoporosis was suspected based on the measurements of bone mineral density, the odds ratio (exercise present/absent) was 0.27 (95% confidence limits: 0.08-0.94), 0.82 (0.65-1.04), 0.78 (0.61-0.99), and 1.25 (0.67-2.35) at 40-49, 50-59, 60-69, and over 70 years, respectively. The results of the present study suggest the beneficial influence of exercise on bone mineral density and its utility for preventing osteoporosis. PMID:9575692

  14. Memory and Aging

    Science.gov (United States)

    Memory and Aging Losing keys, misplacing a wallet, or forgetting someone’s name are common experiences. But for people nearing or over age 65, such memory lapses can be frightening. They wonder if they ...

  15. Polyphenol Intake from Beverages in Japan over an 18-Year Period (1996-2013): Trends by Year, Age, Gender and Season.

    Science.gov (United States)

    Taguchi, Chie; Fukushima, Yoichi; Kishimoto, Yoshimi; Saita, Emi; Suzuki-Sugihara, Norie; Yoshida, Daishi; Kondo, Kazuo

    2015-01-01

    An association between the dietary intake of polyphenols and human health has been shown in many epidemiological studies. Since beverages are rich sources of polyphenols, we aimed to evaluate the polyphenol intake from beverages in Japanese individuals with a focus on differences according to year, age, gender and season. More than 10,000 Japanese male and female subjects aged 1-99 y old participated in this survey every year from 1996 to 2013, and their beverage consumption and amount of polyphenol intake were calculated. Polyphenol intake from beverages in Japan showed no tendency to increase or decrease over the 18-y period, and the major sources of polyphenols in Japanese daily life were coffee and green tea. Polyphenol intake was larger in participants with higher age up to 59 y old in both male and female subjects. There was a slight difference in polyphenol intake by gender, with adult males consuming more polyphenols than adult females. Polyphenols were consumed slightly more in the winter than the summer, although the seasonal difference in polyphenol intake was not large. Our results suggest that polyphenol intake from beverages is influenced by age rather than gender or season in Japan, and may not have changed over time, at least over the 18-y period beginning in 1996 in Japan.

  16. Prevalence of hypertension among individuals aged 50 years and over and its impact on health related quality of life in a semi-rural area of western Turkey

    Institute of Scientific and Technical Information of China (English)

    Didem Arslantas; Unal Ayranci; Alaettin Unsal; Mustafa Tozun

    2008-01-01

    Background Hypertension is common,especially in individuals aged 40 years and over,and it affects about half of the population aged 60 years and over.This study aimed to determine the frequency and risk factors of hypertension among individuals aged 50 years and over,and to examine its effect on the health related quality of life(HRQOL).Methods This population-based cross-sectional study was conducted in two settlements in a region of western Turkey between March 1 and April 30,2007.A questionnaire concerning life habits associated with hypertension,medical histories,and demographic characteristics was filled in by a face to face interview.The SF·36 scale was used to assess HRQOL Body mass index(BMI)was calculated by measuring the weight and length of the body. Results of 1599 individuals living in the region,1193 participated in the survey(48.3%men and 51.7%women).The overall prevalence rate of hypertension was 59.5%(n=710),being 58.O%in men and 60.9% in women(P>0.05).The variables that most positively influenced hypertension(P≤0.05,for each one)were older age(especially the age group of those aged 60 and over),single,no health insurance,consumption of animal fat in meals,and family history of hypertension.The HRQOL of the patients with hypertension was lower than that of those without hypertension(P≤0.05). The HRQOL was better in hypertensive patients whose blood pressure was under control,whereas it was worse in those with at least one chronic disorder accompanying hypertension(P≤0.05,for each one).Conclusions Great emphasis should be placed on the need for a public health program for the detection,prevention, and control of hypertension,including other risk factors,as well as for the modification of foods and life habits,specifically in individuals who are most likely to be at risk of hypertension.

  17. The median non-prostate cancer survival is more than 10 years for men up to age 80 years who are selected and receive curative radiation treatment for prostate cancer

    International Nuclear Information System (INIS)

    Treatment guidelines recommend that curative radiation treatment of prostate cancer be offered only to men whose life expectancy is greater than 10 years. The average life expectancy of North American males is less than 10 years after age 75, yet many men older than 75 years receive curative radiation treatment for prostate cancer. This study used the provincial cancer registry in British Columbia, Canada, to determine median non-prostate cancer survival for men who were aged 75 to 82 years at start of radiation treatment. Median survival was found to be greater than 10 years in men aged up to 80 years at the start of their radiation treatment. This finding suggests that radiation oncologists are able to appropriately select elderly men with greater than average life expectancy to receive curative radiation treatment

  18. Trends in Breast Cancer Incidence Rates by Age and Stage at Diagnosis in Gharbiah, Egypt, over 10 Years (1999–2008

    Directory of Open Access Journals (Sweden)

    Kelly A. Hirko

    2013-01-01

    Full Text Available Background. This study was undertaken to evaluate trends in breast cancer incidence in Egypt from 1999 to 2008 and to make projections for breast cancer occurrence for the years 2009–2015. Patients and Methods. We utilized joinpoint regression and average annual percent change (AAPC measures with 95% confidence intervals (CI to describe the trends in breast cancer incidence rates from the Gharbiah Cancer Registry by age and stage at diagnosis and to estimate expected breast cancer caseloads for 2009–2015. Results. From 1999 to 2008, the AAPC in breast cancer incidence rates in Gharbiah significantly increased among women 50 years and older and among localized tumors (AAPC %, 95% CI, 3.1% to 8.0%. Our results predict a significant increase in breast cancer caseloads from 2009 to 2015 among women aged 30–39 (AAPC %, 95% CI, 0.9% to 1.1% and among women aged 40–49 years (AAPC %, 95% CI, 1.0% to 2.6%. Conclusion. These results have important implications for allocating limited resources, managing treatment needs, and exploring the consequences of prior interventions and/or changing risk factors in Egypt and other developing countries at the same stages of demographic and health transitions.

  19. Detection of Color in Rotating Objects by Infants and Its Generalization over Changes in Velocity.

    Science.gov (United States)

    Burnham, D. K.; Day, R. H.

    1979-01-01

    Three experiments were conducted to examine whether infants can detect the color of stationary and moving objects and maintain this discrimination over change in velocity. Subjects were 80 infants ages 8 to 20 weeks. (MP)

  20. Social gradients in self-reported health and well-being among adults aged 50 and over in Pune District, India

    Directory of Open Access Journals (Sweden)

    Siddhivinayak Hirve

    2010-09-01

    Full Text Available Background: India’s older population is projected to increase up to 96 million by 2011 with older people accounting for 18% of its population by 2051. The Study on Global Ageing and Adult Health aims to improve empirical understanding of health and well-being of older adults in developing countries. Objectives: To examine age and socio-economic changes on a range of key domains in self-reported health and well-being amongst older adults. Design: A cross-sectional survey of 5,430 adults aged 50 and over using a shortened version of the SAGE questionnaire to assess self-reported assessments (scales of 1–5 of performance, function, disability, quality of life and well-being. Self-reported responses were calibrated using anchoring vignettes in eight key domains of mobility, self-care, pain, cognition, interpersonal relationships, sleep/energy, affect, and vision. WHO Disability Assessment Schedule Index and WHO health scores were calculated to examine for associations with socio-demographic variables. Results: Disability in all domains increased with increasing age and decreasing levels of education. Females and the oldest old without a living spouse reported poorer health status and greater disability across all domains. Performance and functionality self-reports were similar across all SES quintiles. Self-reports on quality of life were not significantly influenced by socio-demographic variables. Discussion: The study provides standardised and comparable self-rated health data using anchoring vignettes in an older population. Though expectations of good health, function and performance decrease with age, self-reports of disability severity significantly increased with age, more so if female, if uneducated and living without a spouse. However, the presence or absence of spouse did not significantly alter quality of life self-reports, suggesting a possible protective effect provided by traditional joint family structures in India, where older

  1. Self reported health status, and health service contact, of illicit drug users aged 50 and over: a qualitative interview study in Merseyside, United Kingdom

    Directory of Open Access Journals (Sweden)

    Duffy Paul

    2009-10-01

    Full Text Available Abstract Background The populations of industrialised countries are ageing; as this occurs, those who continue to use alcohol and illicit drugs age also. While alcohol use among older people is well documented, use of illicit drugs continues to be perceived as behaviour of young people and is a neglected area of research. This is the first published qualitative research on the experiences of older drug users in the United Kingdom. Methods Semi-structured interviews were conducted in Merseyside, in 2008, with drug users aged 50 and over recruited through drug treatment services. Interviews were recorded and transcribed and analysed thematically. Only health status and health service contact are reported here. Results Nine men and one woman were interviewed (age range: 54 to 61 years; all but one had been using drugs continuously or intermittently for at least 30 years. Interviewees exhibited high levels of physical and mental morbidity; hepatitis C was particularly prevalent. Injecting-related damage to arm veins resulted in interviewees switching to riskier injecting practices. Poor mental health was evident and interviewees described their lives as depressing. The death of drug-using friends was a common theme and social isolation was apparent. Interviewees also described a deterioration of memory. Generic healthcare was not always perceived as optimal, while issues relating to drug specific services were similar to those arising among younger cohorts of drug users, for example, complaints about inadequate doses of prescribed medication. Conclusion The concurrent effects of drug use and ageing are not well understood but are thought to exacerbate, or accelerate the onset of, medical conditions which are more prevalent in older age. Here, interviewees had poor physical and mental health but low expectations of health services. Older drug users who are not in contact with services are likely to have greater unmet needs. The number of drug users

  2. Cognitive Control Deficits in Shifting and Inhibition in Preschool Age Children are Associated with Increased Depression and Anxiety Over 7.5 Years of Development.

    Science.gov (United States)

    Kertz, Sarah J; Belden, Andy C; Tillman, Rebecca; Luby, Joan

    2016-08-01

    Although depression and anxiety are common in youth (Costello et al. 2003), factors that put children at risk for such symptoms are not well understood. The current study examined associations between early childhood cognitive control deficits and depression and anxiety over the course of development through school age. Participants were 188 children (at baseline M = 5.42 years, SD = 0.79 years) and their primary caregiver. Caregivers completed ratings of children's executive functioning at preschool age and measures of depression and anxiety severity over seven assessment waves (a period of approximately 7.5 years). Longitudinal multilevel linear models were used to examine the effect of attention shifting and inhibition deficits on depression and anxiety. Inhibition deficits at preschool were associated with significantly greater depression severity scores at each subsequent assessment wave (up until 7.5 years later). Inhibition deficits were associated with greater anxiety severity from 3.5 to 7.5 years later. Greater shifting deficits at preschool age were associated with greater depression severity up to 5.5 years later. Shifting deficits were also associated with significantly greater anxiety severity up to 3.5 years later. Importantly, these effects were significant even after accounting for the influence of other key predictors including assessment wave/time, gender, parental education, IQ, and symptom severity at preschool age, suggesting that effects are robust. Overall, findings indicate that cognitive control deficits are an early vulnerability factor for developing affective symptoms. Timely assessment and intervention may be beneficial as an early prevention strategy. PMID:26607383

  3. A Meta analysis on endovascular vs open repair for abdominal aortic aneurysm in patients aged 80 and older%高龄腹主动脉瘤患者治疗方式的选择及疗效比较

    Institute of Scientific and Technical Information of China (English)

    韩彦槊; 张健; 姜晗; 沈世凯; 宋健博; 唐佃俊; 辛世杰; 段志泉

    2015-01-01

    Objective To investigate the therapeutic effect between endovascular repair (EVAR) and open surgical repair (OSR) of AAA in patients aged80 years.Methods We searched MEDLINE (1991.1-2014.7), Ovid (1991.1-2014.7), CBM (1998.1-2014.7) and CNKI (1998.1-2014.7) database.Meta-analyses was performed through software STATA 12.0.Results Eight observational studies reporting on 13 490 octogenarian AAAs were included in this analysis.6 763 AAA patients underwent EVAR and 6 727 AAAs underwent OSR.Although EVAR did not reduce cerebrovascular complication (OR =0.156, P =0.172), EVAR was associated with a significantly lower risk of postoperative cardiac complications (OR =0.092, P =0.008), pulmonary complications (OR =0.059, P =0.011) and renal complications (OR =0.097, P =0.007).Pooled analysis showed lower 30-day mortality after EVAR compared with OSR (OR =0.240, 95% CI: 0.197-0.293, P <0.001).As for medium-long term results, four studies found similar overall survival at 3 years after EVAR and open repair (OR =1.14, P =0.208).Sensitivity analysis including four studies (recruiting AAAs more than 100 cases in each study) found similar 30-day mortality.Conclusions EVAR in aged 80 and older AAAs is associated with significantly lower 30-day mortality and morbidity than OSR.%目的 系统评价80岁以上高龄腹主动脉瘤患者的传统手术及腔内治疗的疗效.方法 计算机检索1991年1月至2014年7月MEDLINE、Ovid、CBM和CNKI数据库.根据纳入和排除标准由两名研究者按Cochrane系统评价方法,独立选择文献、提取资料、评价各研究的方法学质量以及提取有效数据,采用STATA 12.0软件进行Meta分析.结果 共纳入8篇相关文献;共统计13 490例高龄腹主动脉瘤(abdominal aortic aneurysm,AAA)患者,其中腔内修复技术(endovascularrepair,EVAR)组6 763例,人工血管移植术(open surgical repair,OSR)组6 727例.术后早期EVAR组的心脏并发症发生率明显低于OSR

  4. Effect of multivitamin and multimineral supplementation on cognitive function in men and women aged 65 years and over: a randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Ramsay Craig R

    2007-05-01

    Full Text Available Abstract Background Observational studies have frequently reported an association between cognitive function and nutrition in later life but randomised trials of B vitamins and antioxidant supplements have mostly found no beneficial effect. We examined the effect of daily supplementation with 11 vitamins and 5 minerals on cognitive function in older adults to assess the possibility that this could help to prevent cognitive decline. Methods The study was carried out as part of a randomised double blind placebo controlled trial of micronutrient supplementation based in six primary care health centres in North East Scotland. 910 men and women aged 65 years and over living in the community were recruited and randomised: 456 to active treatment and 454 to placebo. The active treatment consisted of a single tablet containing eleven vitamins and five minerals in amounts ranging from 50–210 % of the UK Reference Nutrient Intake or matching placebo tablet taken daily for 12 months. Digit span forward and verbal fluency tests, which assess immediate memory and executive functioning respectively, were conducted at the start and end of the intervention period. Risk of micronutrient deficiency at baseline was assessed by a simple risk questionnaire. Results For digit span forward there was no evidence of an effect of supplements in all participants or in sub-groups defined by age or risk of deficiency. For verbal fluency there was no evidence of a beneficial effect in the whole study population but there was weak evidence for a beneficial effect of supplementation in the two pre-specified subgroups: in those aged 75 years and over (n 290; mean difference between supplemented and placebo groups 2.8 (95% CI -0.6, 6.2 units and in those at increased risk of micronutrient deficiency assessed by the risk questionnaire (n 260; mean difference between supplemented and placebo groups 2.5 (95% CI -1.0, 6.1 units. Conclusion The results provide no evidence for a

  5. Social isolation and loneliness in people aged 55 and over in Milton Keynes: developing an action plan

    OpenAIRE

    Minocha, Shailey; Holland, Caroline; McNulty, Catherine; Banks, Duncan; Palmer, Jane

    2016-01-01

    In this workshop, we outlined the conditions that lead to social isolation and loneliness among older people (55 years and above) in Milton Keynes, and recommended possible strategies and solutions to prevent and mitigate isolation. The findings are based on the Milton Keynes Council-commissioned report http://oro.open.ac.uk/43925/. The research involved a review of academic and policy literature on social isolation and loneliness, and an information gathering exercise that included expert w...

  6. Prevalence and risk factors for vitamin C deficiency in north and south India: a two centre population based study in people aged 60 years and over.

    Directory of Open Access Journals (Sweden)

    Ravilla D Ravindran

    Full Text Available BACKGROUND: Studies from the UK and North America have reported vitamin C deficiency in around 1 in 5 men and 1 in 9 women in low income groups. There are few data on vitamin C deficiency in resource poor countries. OBJECTIVES: To investigate the prevalence of vitamin C deficiency in India. DESIGN: We carried out a population-based cross-sectional survey in two areas of north and south India. Randomly sampled clusters were enumerated to identify people aged 60 and over. Participants (75% response rate were interviewed for tobacco, alcohol, cooking fuel use, 24 hour diet recall and underwent anthropometry and blood collection. Vitamin C was measured using an enzyme-based assay in plasma stabilized with metaphosphoric acid. We categorised vitamin C status as deficient (28 µmol/L. We investigated factors associated with vitamin C deficiency using multivariable Poisson regression. RESULTS: The age, sex and season standardized prevalence of vitamin C deficiency was 73.9% (95% confidence Interval, CI 70.4,77.5 in 2668 people in north India and 45.7% (95% CI 42.5,48.9 in 2970 from south India. Only 10.8% in the north and 25.9% in the south met the criteria for adequate levels. Vitamin C deficiency varied by season, and was more prevalent in men, with increasing age, users of tobacco and biomass fuels, in those with anthropometric indicators of poor nutrition and with lower intakes of dietary vitamin C. CONCLUSIONS: In poor communities, such as in our study, consideration needs to be given to measures to improve the consumption of vitamin C rich foods and to discourage the use of tobacco.

  7. Association of Risk Perception and Information Provided on the Labels of Over-the-Counter Drugs: Role of Race, Education, Age and Income

    Directory of Open Access Journals (Sweden)

    Sunil Mathur

    2014-01-01

    Full Text Available Background: The use of over-the-counter (OTC drugs has increased tremendously, however, information on risk perception regarding the use of OTC drugs and their potential toxicity is scarce. Hence, the purpose of this study was to investigate the perception of OTC drug safety and efficacy based on reading product packaging and the effect of race, education, age and income. Methods: We used the HINTS 2012 data set with total sample size of 2,554. Results: OTC drug users having some high school education had a lower chance of frequently reading information included in the product labeling with the OTC medication. OTC drug users less than 50 years of age were always likely to read drug information on the OTC drug labeling. Also, Non-Hispanic blacks were more likely to read OTC drug labeling than Non-Hispanic whites.  OTC drug users less than 50 years of age consider OTC drugs safer than prescription drugs.  Conversely, OTC drug users with a high school, some college or bachelor’s degree consider OTC drugs less safe than prescription drugs.  Non-Hispanic blacks, non-Hispanic whites, and subjects of lower income were less likely to consider OTC drugs safer than prescription drugs.  OTC drug users with a high school education and some college perceive OTC drugs to be less effective than prescription drugs.Conclusion: To conclude, age, education, race, and income affect risk perception on OTC drugs.  Consumer information programs need to be designed so that meaningful results can be incorporated into public policy. Providing information on the labeling of OTC drugs and likelihood of patients reading this information require further study.

  8. [Quality of the diet of the Spanish population over 80 years non-institutionalized].

    Science.gov (United States)

    Hernández Galiot, Ana; Goñi Cambrodón, Isabel

    2015-06-01

    Introducción: los adultos mayores no institucionalizados son un colectivo que suele presentar alto riesgo de malnutrición. Detectar problemas nutricionales mediante indicadores de la calidad global de la dieta, es un reto para los profesionales de la salud, de utilidad para la planificación de políticas nutricionales. Objetivo: determinar la calidad global de la dieta de la población española mayor de 80 años no institucionalizada, para promover y fomentar la calidad de vida del anciano. Metodología: se seleccionaron las personas mayores de 80 años del Estudio Longitudinal Envejecer en España 2011-2013 (n = 159), residentes en diversas zonas españolas. Para valorar la calidad de la dieta se utilizó el índice de alimentación saludable (IAS), la frecuencia de consumo de alimentos y el grado de adhesión al patrón de dieta Mediterránea (ADM). Resultados: la población presentó valores de IAS cercanos a los correspondientes a una dieta saludable. Un porcentaje significativo necesitaba cambios en su alimentación, siendo los mayores de 90 años los que requirieron una mayor intervención dietética. La mayoría de la población cumplió las recomendaciones de la dieta mediterránea, aunque se observó bajo consumo de verduras, hortalizas, frutos secos y vino; y elevado consumo de embutidos. Conclusiones: la dieta consumida habitualmente por los españoles mayores de 80 años no institucionalizados presenta desajustes nutricionales que podrían corregirse realizando pequeños cambios en su patrón dietético. Determinar la calidad global de la dieta permite la planificación de estrategias de intervención para promover cambios alimentarios saludables y emprender acciones orientadas al mantenimiento de una salud óptima en el binomio envejecimiento-nutrición.

  9. 9 CFR 71.18 - Individual identification of certain cattle 2 years of age or over for movement in interstate...

    Science.gov (United States)

    2010-01-01

    ... cattle 2 years of age or over for movement in interstate commerce. 71.18 Section 71.18 Animals and Animal... certain cattle 2 years of age or over for movement in interstate commerce. (a) No cattle 2 years of age or over, except steers and spayed heifers and cattle of any age which are being moved interstate...

  10. How Do African American Young Adult Females (AAYAF) over 16 Years of Age Make Career Decisions?

    Science.gov (United States)

    Grayson, Nancy Mathea

    2010-01-01

    Scope and Method of Study: The overall purpose of the study was to describe the perceptions regarding how AAYAF over 16 years of age plan and make career decisions. The study participants included ten AAYAF over 16 years of age. The young women were interviewed fact-to-face using a semi-structured open-ended questionnaire. The questionnaire was…

  11. Adherence to and appropriateness of anti-osteoporotic treatments in patients aged 50 and over in the Valencia Region (Spain. The ESOSVAL-AD Study

    Directory of Open Access Journals (Sweden)

    Ruiz Vicente

    2011-08-01

    Full Text Available Summary Background A study to evaluate the adherence to and appropriateness of anti-osteoporotic treatments in a cohort of men and women aged 50 and over participating in the ESOSVAL-R study. Methods/Design Design: An observational, longitudinal, prospective cohort study; Study subjects: Men and women aged 50 and over living in the Valencia Region (Spain who initiated treatment between June 15, 2009, and June 15, 2011, in primary healthcare centers with electronic medical records; Data sources: The main data source will be electronic medical records. Measurement of results: Degree of compliance with and persistence of anti-osteoporotic treatments, and the proportion of patients with appropriate anti-osteoporotic treatment in accordance with the most relevant and high impact recommendations with clearly defined treatment algorithms in Spain (the Spanish National Health System guide (2010, the General Practitioners' Society (2007 and the General Directorate for Pharmacy and Medical Products of Madrid (2007, and with the National Osteoporosis Foundation (NOF, 2010, and the International Osteoporosis Foundation guidelines (IOF, 2008; Analysis: 1. Descriptive analysis of patients undergoing treatment and the treatments prescribed; 2. Descriptive analysis of compliance with and persistence of anti-osteoporotic treatments; 3. Analysis of factors associated with compliance with and persistence of treatments by Cox proportional hazard regression models, 4. Descriptive analysis of appropriateness of treatment; 5. Analysis of factors associated with the appropriateness of treatment by multilevel models (4 levels: patient, doctor, Basic Healthcare Zone/Primary Healthcare Center, and Health Area variables. Discussion ESOSVAL-AD will provide information regarding adherence to osteoporosis treatments and the factors associated with a higher or lower adherence (including the appropriateness of the treatment in the Spanish context. A better understanding of this

  12. Sex Differences in Medication and Primary Healthcare Use before and after Spousal Bereavement at Older Ages in Denmark: Nationwide Register Study of over 6000 Bereavements

    Directory of Open Access Journals (Sweden)

    Anna Oksuzyan

    2011-01-01

    Methods. All individuals alive and aged at least 60 years in 1996 and who became widowed in the period from 1996 to 2003 were selected from the 5% sample of the total Danish population and all Danish twins. The healthcare use was assessed as the average daily all-cause and major system-specific medication use and the average annual number of visits to general physicians (GPs. Results. The average daily use of all-cause and major system-specific medications, as well as the number of GP visits increased over the period from 1 year before and up to 5 years after a spouse's death, but there were no sex-specific patterns in the trajectories of medication use and number of GP visits after conjugal loss. Conclusion. We found little support for the hypothesis that reduced healthcare use contributes to the explanation of more adverse health outcomes after conjugal loss in men compared with women in Denmark.

  13. Social class differences in secular trends in established coronary risk factors over 20 years: a cohort study of British men from 1978-80 to 1998-2000.

    Directory of Open Access Journals (Sweden)

    Sheena E Ramsay

    Full Text Available BACKGROUND: Coronary heart disease (CHD mortality in the UK since the late 1970s has declined more markedly among higher socioeconomic groups. However, little is known about changes in coronary risk factors in different socioeconomic groups. This study examined whether changes in established coronary risk factors in Britain over 20 years between 1978-80 and 1998-2000 differed between socioeconomic groups. METHODS AND FINDINGS: A socioeconomically representative cohort of 7735 British men aged 40-59 years was followed-up from 1978-80 to 1998-2000; data on blood pressure (BP, cholesterol, body mass index (BMI and cigarette smoking were collected at both points in 4252 survivors. Social class was based on longest-held occupation in middle-age. Compared with men in non-manual occupations, men in manual occupations experienced a greater increase in BMI (mean difference = 0.33 kg/m(2; 95%CI 0.14-0.53; p for interaction = 0.001, a smaller decline in non-HDL cholesterol (difference in mean change = 0.18 mmol/l; 95%CI 0.11-0.25, p for interaction≤0.0001 and a smaller increase in HDL cholesterol (difference in mean change = 0.04 mmol/l; 95%CI 0.02-0.06, p for interaction≤0.0001. However, mean systolic BP declined more in manual than non-manual groups (difference in mean change = 3.6; 95%CI 2.1-5.1, p for interaction≤0.0001. The odds of being a current smoker in 1978-80 and 1998-2000 did not differ between non-manual and manual social classes (p for interaction = 0.51. CONCLUSION: Several key risk factors for CHD and type 2 diabetes showed less favourable changes in men in manual occupations. Continuing priority is needed to improve adverse cardiovascular risk profiles in socially disadvantaged groups in the UK.

  14. Social Class Differences in Secular Trends in Established Coronary Risk Factors over 20 Years: A Cohort Study of British Men from 1978–80 to 1998–2000

    Science.gov (United States)

    Ramsay, Sheena E.; Whincup, Peter H.; Hardoon, Sarah L.; Lennon, Lucy T.; Morris, Richard W.; Wannamethee, S. G.

    2011-01-01

    Background Coronary heart disease (CHD) mortality in the UK since the late 1970s has declined more markedly among higher socioeconomic groups. However, little is known about changes in coronary risk factors in different socioeconomic groups. This study examined whether changes in established coronary risk factors in Britain over 20 years between 1978–80 and 1998–2000 differed between socioeconomic groups. Methods and Findings A socioeconomically representative cohort of 7735 British men aged 40–59 years was followed-up from 1978–80 to 1998–2000; data on blood pressure (BP), cholesterol, body mass index (BMI) and cigarette smoking were collected at both points in 4252 survivors. Social class was based on longest-held occupation in middle-age. Compared with men in non-manual occupations, men in manual occupations experienced a greater increase in BMI (mean difference = 0.33 kg/m2; 95%CI 0.14–0.53; p for interaction = 0.001), a smaller decline in non-HDL cholesterol (difference in mean change = 0.18 mmol/l; 95%CI 0.11–0.25, p for interaction≤0.0001) and a smaller increase in HDL cholesterol (difference in mean change = 0.04 mmol/l; 95%CI 0.02–0.06, p for interaction≤0.0001). However, mean systolic BP declined more in manual than non-manual groups (difference in mean change = 3.6; 95%CI 2.1–5.1, p for interaction≤0.0001). The odds of being a current smoker in 1978–80 and 1998–2000 did not differ between non-manual and manual social classes (p for interaction = 0.51). Conclusion Several key risk factors for CHD and type 2 diabetes showed less favourable changes in men in manual occupations. Continuing priority is needed to improve adverse cardiovascular risk profiles in socially disadvantaged groups in the UK. PMID:21603647

  15. Stein and Leventhal: 80 years on.

    Science.gov (United States)

    Azziz, Ricardo; Adashi, Eli Y

    2016-02-01

    Eighty years ago a publication in the Journal proved to be seminal and transformative. The report by Irving Freiler Stein and Michael Leventhal titled, "Amenorrhea associated with polycystic ovaries," has proven to be a remarkably lasting and influential publication. The growth in related literature has been increasing exponentially: the 50 years between 1950 and 2000 saw a little more than 8000 publications on the topic, whereas the 15 year period between 2001 and 2015 (so far) has seen more than 20,000 related publications, a greater than 8-fold increase in the publication rate after 2000. As we commemorate the 80th anniversary year of the publication of the report by Stein and Leventhal, it is important to ask ourselves, "Was this publication truly as seminal as it is generally assumed to be? And why did it gain such a strong foothold on the medical psyche?" To the first question, a review of the antecedent medical literature makes it clear that the report of Drs Stein and Leventhal in 1935, although not flawless, was both seminal and transformative. In fact, it was the first report to describe a series of patients, rather than isolated cases, who demonstrated the triad of polycystic ovaries, hirsutism, and oligo/amenorrhea, connecting what had previously been disparate features of polycystic ovaries and menorrhagia, and hirsutism and oligo/amenorrhea. Second, the facts that Dr Stein and his collaborators were relatively prolific writers, consistent and clear in their message and descriptions; that a possible therapy (bilateral ovarian wedge resection) had been conveniently included in the report; and that the disorder was (is) relatively prevalent, permitted what would eventually be called the Stein-Leventhal syndrome to gain a strong foothold in contemporary medical practice. Overall, we in the field of medicine have much to celebrate, as we commemorate the 80th anniversary of the publication of the report by Stein and Leventhal in 1935, for a new disorder was

  16. Is there a role for wine in cancer and the degenerative diseases of aging?

    OpenAIRE

    Creina S Stockley

    2009-01-01

    Creina S StockleyThe Australian Wine Research Institute, Adelaide, South Australia, AustraliaAbstract: Population aging is associated with the increased incidence cancer and of degenerative diseases. Population aging is occurring on a global scale, with faster aging projected for the coming decades than has occurred in the past. Globally, the population aged 60 years and over is projected to nearly triple by 2050, while the population aged 80 years and over is projected to experience a more t...

  17. Hearing in old age - epidemiological and etiological aspects

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Introduction The number of elderly persons is increasing all over the world. This strong demographic trend will affect our societies profoundly. Since the largest relative increase is expected to occur in the group of very old persons, over 80 years of age, the demands on the society and on relatives in terms of health- and social care are considerable.

  18. Aging and atherosclerosis in human and nonhuman primates

    OpenAIRE

    Cefalu, William T.; Wagner, Janice D.

    1997-01-01

    Atherosclerosis is a major age-related process and public health problem and its clinical manifestations (coronary heart disease [CHD] and cerebrovascular disease) continue to be responsible for approximately 50% of all deaths occurring annually. In addition, CHD is responsible for over 70 to 80% of deaths among men and women over 65 years old. As our population ages (35 million people over the age of 65 in the U.S. by the year 2030) and because of the increased morbidity and mortality associ...

  19. Use of Spirometry and Respiratory Drugs in Manitobans Over 35 Years of Age with Obstructive Lung Diseases

    OpenAIRE

    NR Anthonisen; K Woodlrage; J Manfreda

    2005-01-01

    BACKGROUND: Previous data indicated that spirometry was underused in people with obstructive disease, especially those with chronic obstructive pulmonary disease (COPD).OBJECTIVE: To examine the use of respiratory drugs in patients with COPD and asthma, and to relate drug use to spirometry.METHODS: Manitoba Health maintains a database of physician services remunerated by fees that includes spirometry. The database contains the diagnosis and patient identifiers, as well as sex, date of birth a...

  20. Oxygenated compounds in aged biomass burning plumes over the Eastern Mediterranean: evidence for strong secondary production of methanol and acetone

    Directory of Open Access Journals (Sweden)

    R. Holzinger

    2004-10-01

    Full Text Available Airborne measurements of acetone, methanol, PAN, acetonitrile (by Proton Transfer Reaction Mass Spectrometry, and CO (by Tunable Diode Laser Absorption Spectroscopy have been performed during the Mediterranean Intensive Oxidants Study (MINOS, August 2001. In the course of the campaign 10 biomass burning plumes, identified by strongly elevated acetonitrile mixing ratios, were found. The characteristic biomass burning signatures obtained from these plumes reveal secondary production of acetone and methanol, while CO photochemically declines in the plumes. Mean excess mixing ratios – normalized to CO – of 1.8%, 0.20%, 3.8%, and 0.65% for acetone, acetonitrile, methanol, and PAN, respectively, were found in the plumes. By scaling to an assumed global annual source of 663–807 Tg CO, biomass burning emissions of 25–31 and 29–35 Tg/yr for acetone and methanol are estimated, respectively. Our measurements suggest that the present biomass burning contributions of acetone and methanol are significantly underestimated due to the neglect of secondary formation. Median acetonitrile mixing ratios throughout the troposphere were around 150 pmol/mol; this is in accord with current biomass burning inventories and an atmospheric lifetime of ~6 months.

  1. Social Factors Influencing Russian Male Alcohol Use over the Life Course: A Qualitative Study Investigating Age Based Social Norms, Masculinity, and Workplace Context.

    Directory of Open Access Journals (Sweden)

    Katherine Keenan

    Full Text Available The massive fluctuations occurring in Russian alcohol-related mortality since the mid-1980s cannot be seen outside of the context of great social and economic change. There is a dearth of qualitative studies about Russian male drinking and especially needed are those that address social processes and individual changes in drinking. Conducted as part of a longitudinal study on men's alcohol consumption in Izhevsk, this qualitative study uses 25 semi-structured biographical interviews with men aged 33-60 years to explore life course variation in drinking. The dominant pattern was decreasing binge and frequent drinking as men reached middle age which was precipitated by family building, reductions in drinking with work colleagues, and health concerns. A minority of men described chaotic drinking histories with periods of abstinence and heavy drinking. The results highlight the importance of the blue-collar work environment for conditioning male heavy drinking in young adulthood through a variety of social, normative and structural mechanisms. Post-Soviet changes had a structural influence on the propensity for workplace drinking but the important social function of male drinking sessions remained. Bonding with workmates through heavy drinking was seen as an unavoidable and essential part of young men's social life. With age peer pressure to drink decreased and the need to perform the role of responsible breadwinner put different behavioural demands on men. For some resisting social pressure to drink became an important site of self-determination and a mark of masculine maturity. Over the lifetime the place where masculine identity was asserted shifted from the workplace to the home, which commonly resulted in a reduction in drinking. We contribute to existing theories of Russian male drinking by showing that the performance of age-related social roles influences Russian men's drinking patterns, drinking contexts and their attitudes. Further

  2. Social Factors Influencing Russian Male Alcohol Use over the Life Course: A Qualitative Study Investigating Age Based Social Norms, Masculinity, and Workplace Context.

    Science.gov (United States)

    Keenan, Katherine; Saburova, Lyudmila; Bobrova, Natalia; Elbourne, Diana; Ashwin, Sarah; Leon, David A

    2015-01-01

    The massive fluctuations occurring in Russian alcohol-related mortality since the mid-1980s cannot be seen outside of the context of great social and economic change. There is a dearth of qualitative studies about Russian male drinking and especially needed are those that address social processes and individual changes in drinking. Conducted as part of a longitudinal study on men's alcohol consumption in Izhevsk, this qualitative study uses 25 semi-structured biographical interviews with men aged 33-60 years to explore life course variation in drinking. The dominant pattern was decreasing binge and frequent drinking as men reached middle age which was precipitated by family building, reductions in drinking with work colleagues, and health concerns. A minority of men described chaotic drinking histories with periods of abstinence and heavy drinking. The results highlight the importance of the blue-collar work environment for conditioning male heavy drinking in young adulthood through a variety of social, normative and structural mechanisms. Post-Soviet changes had a structural influence on the propensity for workplace drinking but the important social function of male drinking sessions remained. Bonding with workmates through heavy drinking was seen as an unavoidable and essential part of young men's social life. With age peer pressure to drink decreased and the need to perform the role of responsible breadwinner put different behavioural demands on men. For some resisting social pressure to drink became an important site of self-determination and a mark of masculine maturity. Over the lifetime the place where masculine identity was asserted shifted from the workplace to the home, which commonly resulted in a reduction in drinking. We contribute to existing theories of Russian male drinking by showing that the performance of age-related social roles influences Russian men's drinking patterns, drinking contexts and their attitudes. Further research should be

  3. Social Factors Influencing Russian Male Alcohol Use over the Life Course: A Qualitative Study Investigating Age Based Social Norms, Masculinity, and Workplace Context.

    Science.gov (United States)

    Keenan, Katherine; Saburova, Lyudmila; Bobrova, Natalia; Elbourne, Diana; Ashwin, Sarah; Leon, David A

    2015-01-01

    The massive fluctuations occurring in Russian alcohol-related mortality since the mid-1980s cannot be seen outside of the context of great social and economic change. There is a dearth of qualitative studies about Russian male drinking and especially needed are those that address social processes and individual changes in drinking. Conducted as part of a longitudinal study on men's alcohol consumption in Izhevsk, this qualitative study uses 25 semi-structured biographical interviews with men aged 33-60 years to explore life course variation in drinking. The dominant pattern was decreasing binge and frequent drinking as men reached middle age which was precipitated by family building, reductions in drinking with work colleagues, and health concerns. A minority of men described chaotic drinking histories with periods of abstinence and heavy drinking. The results highlight the importance of the blue-collar work environment for conditioning male heavy drinking in young adulthood through a variety of social, normative and structural mechanisms. Post-Soviet changes had a structural influence on the propensity for workplace drinking but the important social function of male drinking sessions remained. Bonding with workmates through heavy drinking was seen as an unavoidable and essential part of young men's social life. With age peer pressure to drink decreased and the need to perform the role of responsible breadwinner put different behavioural demands on men. For some resisting social pressure to drink became an important site of self-determination and a mark of masculine maturity. Over the lifetime the place where masculine identity was asserted shifted from the workplace to the home, which commonly resulted in a reduction in drinking. We contribute to existing theories of Russian male drinking by showing that the performance of age-related social roles influences Russian men's drinking patterns, drinking contexts and their attitudes. Further research should be

  4. Spectral-domain optical coherence tomography in subjects over 60 years of age, and its implications for designing clinical trials

    NARCIS (Netherlands)

    Caramoy, A.; Foerster, J.; Allakhiarova, E.; Hoyng, C.B.; Droge, K.; Kirchhof, B.; Fauser, S.

    2012-01-01

    AIMS: To study the variability of central retinal thickness (CRT), its concordance to the fellow eye, and the implications for designing future clinical trials using spectral-domain optical coherence tomography (SD-OCT). METHODS: Cross-sectional retrospective analysis of European Genetic Database. 6

  5. The prevalence of hypertension, obesity and dyslipidemia in individuals of over 30 years of age belonging to minorities from the pasture area of Xinjiang

    Directory of Open Access Journals (Sweden)

    Luo Wen-Li

    2010-02-01

    Full Text Available Abstract Background The prevalence of population-wide hypertension, obesity and dyslipidemia has not been well studied in the pasture area of Xinjiang. The present epidemiological study was performed to determine the prevalence of hypertension, obesity and dyslipidemia in minority populations from the pasture area of Xinjiang and to discuss the potential risk factors for hypertension. Methods A population-based, cross-sectional study in the Xinjiang pasture area was performed which included 2251 participants aged over 30 years (90.33% participation rate of whom 71.26% were Kazaks. Several risk factors were considered: hypertension (defined as systolic or diastolic blood pressure or both of at least 140/90 mmHg measured on one occasion or treatment for hypertension overweight/obesity (body mass index ≥ 25 kg/m2 alcohol intake, smoking/tobacco use and dyslipidemia. Outcomes were prevalence of hypertension, obesity and dyslipidemia and the associated risk factors of hypertension detected by multivariate logistic regression analysis taking into account various metabolic and lifestyle characteristics. Results The prevalence of hypertension, overweight/obesity and dyslipidemia in all participants from the pasture area of Xinjiang was 51.9%, 47.9% and 49.2% respectively. Independently, the prevalence and awareness of hypertension was 52.6% and 15.3% among Kazaks (n = 1604, 54.6% and 14.1% among Uygurs (n = 418, 39.5% and 16.1% among Mongolians (n = 81 and 43.9% and 18.2% among non-Xinjiang-born Han immigrants (n = 148. The prevalence of overweight/obesity in Kazaks, Uygurs, Mongolians and Han immigrants was 46.7%, 48.9%, 62.5% and 50.3%, respectively. The prevalence of dyslipidemia in the four ethnic groups mentioned was 53.5%, 34.8%, 49.3% and 47.3%, respectively. The mean blood pressure in all participants was 136/86 mmHg (pre-hypertensive, the mean BMI was 24.7 kg/m2. Based on multiple logistic regression analysis, the significant risk factors for

  6. [Stroke and aging].

    Science.gov (United States)

    Ly, J; Maquet, P

    2014-01-01

    Stroke risk increases with aging and one third of ischemic strokes occurs in very elderly (> or = 80 years). These are responsible of two thirds of the overall stroke-related morbi-mortality. Stroke in very elderly differs from younger individuals by sex ratio (more women), risk factors (more atrial fibrillation and hypertension) and usually a worse functional outcome. Very elderly are likely to benefit from stroke unit care and early revascularisation treatments although they have historically been excluded from this urgent management. These issues are likely to worsen in the future with the increasing impact of stroke on our aging societies.

  7. Student Characteristics and Behaviors at Age 12 Predict Occupational Success 40 Years Later over and above Childhood IQ and Parental Socioeconomic Status

    Science.gov (United States)

    Spengler, Marion; Brunner, Martin; Damian, Rodica I.; Lüdtke, Oliver; Martin, Romain; Roberts, Brent W.

    2015-01-01

    Drawing on a 2-wave longitudinal sample spanning 40 years from childhood (age 12) to middle adulthood (age 52), the present study was designed to examine how student characteristics and behaviors in late childhood (assessed in Wave 1 in 1968) predict career success in adulthood (assessed in Wave 2 in 2008). We examined the influence of parental…

  8. Fontes energéticas para bezerros de corte desmamados aos 80 dias de idade Energy supplements for beef calves weaned at 80 days of age

    Directory of Open Access Journals (Sweden)

    João Restle

    2006-06-01

    ão alimentar nos tratamentos com GM (4,21 foi melhor que naqueles com CS (4,80.In this study different energy supplements for feedlot calves weaned at 80 days of age and averaging 90 kg of body weight were evaluated. The following energy sources were used: corn grain (CG, rice bran (RB, soybean hulls (SH, corn grain + rice bran (CG + RB, soybean hulls + rice bran (SH + RB or corn grain + soybean hulls (CG + SH. The diets were isonitrogenous (13% crude protein with a 50:50 forage:concentrate ratio. Sorghum silage (AG-2005E constituted the forage portion of the diet. No significant differences were observed for dry matter intakes (DMI expressed in kg (4.43 kg, per 100 kg of body weight (3.17% or per unit of metabolic weight (109.10 g. Calves fed SH showed greater intake of NDF than those fed CG expressed in kg per day, per 100 kg of body weight and per unit of metabolic weight (2.41 kg, 1.73% and 59.46 g vs. 1.44 kg, 1.02% and 35.01 g, respectively. Daily digestible energy intake (DEI was similar among treatments as well as the average daily weight gain (.986 kg, feed conversion (4.52 kg DMI/kg of weight gain and energy efficiency (12.23 Mcal DEI/kg of weight gain. However, when compared by contrast analyses both diets with SH (SH and SH + RB and both diets with CG (CG and CG + RB, it was observed that animals receiving diets with soybean hulls consumed more DM than animals fed corn grain expressed either per 100 kg of body weight (3.28 vs. 3.06% or per unit of metabolic weight - MW (112.67 vs. 105.59 g. It was also observed differences in DEI, being greater for diets containing corn grain (12.47 Mcal/day and .304 Mcal/MW compared to those containing SH (11.67 Mcal/day and .288 Mcal/MW. Feed conversion improved on calves fed diets with CG (4.21 than on those fed soybean hulls (4.80.

  9. Psychological Treatment of Depression in People Aged 65 Years and Over: A Systematic Review of Efficacy, Safety, and Cost-Effectiveness

    Science.gov (United States)

    Jonsson, Ulf; Bertilsson, Göran; Gyllensvärd, Harald; Söderlund, Anne; Tham, Anne; Andersson, Gerhard

    2016-01-01

    Objectives Depression in elderly people is a major public health concern. As response to antidepressants is often unsatisfactory in this age group, there is a need for evidence-based non-pharmacological treatment options. Our objectives were twofold: firstly, to synthesize published trials evaluating efficacy, safety and cost-effectiveness of psychological treatment of depression in the elderly and secondly, to assess the quality of evidence. Method The electronic databases PubMed, EMBASE, Cochrane Library, CINAL, Scopus, and PsycINFO were searched up to 23 May 2016 for randomized controlled trials (RCTs) of psychological treatment for depressive disorders or depressive symptoms in people aged 65 years and over. Two reviewers independently assessed relevant studies for risk of bias. Where appropriate, the results were synthesized in meta-analyses. The quality of the evidence was graded according to GRADE (Grading of Recommendations Assessment, Development and Evaluation). Results Twenty-two relevant RCTs were identified, eight of which were excluded from the synthesis due to a high risk of bias. Of the remaining trials, six evaluated problem-solving therapy (PST), five evaluated other forms of cognitive behavioural therapy (CBT), and three evaluated life review/reminiscence therapy. In frail elderly with depressive symptoms, the evidence supported the efficacy of PST, with large but heterogeneous effect sizes compared with treatment as usual. The results for life-review/reminiscence therapy and CBT were also promising, but because of the limited number of trials the quality of evidence was rated as very low. Safety data were not reported in any included trial. The only identified cost-effectiveness study estimated an incremental cost per additional point reduction in Beck Depression Inventory II score for CBT compared with talking control and treatment as usual. Conclusion Psychological treatment is a feasible option for frail elderly with depressive symptoms

  10. Elevated O3 in Fresh and Aged Lightning-NOx Plumes Interacting with Biomass Burning Plumes over the Central U.S. during DC3 (Invited)

    Science.gov (United States)

    Huntrieser, H.; Lichtenstern, M.; Scheibe, M.; Aufmhoff, H.; Schlager, H.; Pucik, T.; Minikin, A.; Weinzierl, B.; Heimerl, K.; Fütterer, D.; Rappenglück, B.; Ackermann, L.; Pickering, K. E.; Cummings, K.; Barth, M. C.

    2013-12-01

    During the Deep Convective Clouds and Chemistry Experiment (DC3) in summer 2012 a variety of different thunderstorm systems were investigated over the Central U.S. by the DLR research aircraft Falcon together with the NCAR GV and NASA DC-8 aircraft. In addition, the complete DC3 field phase was characterized by a number of extended wildfires burning in the surroundings of the thunderstorms. Here we mainly focus on trace gas in situ measurements, such as NOx, CO, O3, CH4, SO2, NMHC, and a variety of aerosol measurements carried out by the Falcon in the fresh (~0-6 h) and aged (~12-24 h) anvil outflow at ~10-12 km altitude. It is well-known that thunderstorms modify the trace gas composition in the upper troposphere (UT) and may affect O3 mixing ratios, an important greenhouse gas in the UT. However, a complete picture of the different processes affecting the UT-O3 composition in vicinity of thunderstorms and its large-scale effects is still missing. From the DC3 data set we present an example of small-scale effects on the O3 composition in the anvil outflow, such as immediate O3 production by an aircraft-induced flash. But we also show how the efficient convective transport that extended over the whole updraft region may transport O3-poorer air masses from the, in general, rather unpolluted inflow region (with regard to anthropogenic emissions) over the Central U.S. directly to the UT. However, in a few cases enhanced O3 mixing ratios were observed in the anvil outflow attributed to different chemical and dynamical processes. In the two most powerful convective systems, an intense MCS over Missouri/Arkansas and a supercell over Texas, extended biomass burning (BB) plumes from New Mexico interacted with the thunderstorms. Ozone production was obvious in the BB plumes transported mainly in the lower troposphere at ~2-5 km altitude (ΔO3/ΔCO=0.1). However, if these air masses affected by BB emissions (containing high amounts of O3 precursors such as CH4 and NMHC) were

  11. Ages of Type Ia Supernovae Over Cosmic Time

    OpenAIRE

    Childress, Michael J.; Wolf, Christian; Zahid, H. Jabran

    2014-01-01

    We derive empirical models for galaxy mass assembly histories, and convolve these with theoretical delay time distribution (DTD) models for Type Ia supernovae (SNe Ia) to derive the distribution of progenitor ages for all SNe Ia occurring at a given epoch of cosmic time. In actively star-forming galaxies, the progression of the star formation rate is shallower than a $t^{-1}$ SN Ia DTD, so mean SN Ia ages peak at the DTD peak in all star-forming galaxies at all epochs of cosmic history. In pa...

  12. Ages of Type Ia supernovae over cosmic time

    OpenAIRE

    Childress, M. J.; Wolf, C.; Zahid, H.J.

    2014-01-01

    We derive empirical models for galaxy mass assembly histories, and convolve these with theoretical delay time distribution (DTD) models for Type Ia supernovae (SNe Ia) to derive the distribution of progenitor ages for all SNe Ia occurring at a given epoch of cosmic time. In actively star-forming galaxies, the progression of the star formation rate is shallower than a t?1 SN Ia DTD, so mean SN Ia ages peak at the DTD peak in all star-forming galaxies at all epochs of cosmic history. In passive...

  13. 21 CFR 226.80 - Packaging and labeling.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Packaging and labeling. 226.80 Section 226.80 Food...: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR TYPE A MEDICATED ARTICLES Packaging and Labeling § 226.80 Packaging and labeling. (a) Packaging and labeling operations shall be adequately controlled: (1) To...

  14. Changes in Oxidative Stress and Inflammatory Biomarkers in Fragile Adults over Fifty Years of Age and in Elderly People Exclusively Fed Enteral Nutrition

    Science.gov (United States)

    Mesa, Maria D.; Olza, Josune; Gonzalez-Anton, Carolina; Aguilera, Concepcion M.; Moreno-Torres, Rosario; Jimenez, Africa; Perez de la Cruz, Antonio; Ruperez, Azahara I.; Gil, Angel

    2016-01-01

    We aim to evaluate whether exclusive feeding of an enteral formula enriched with n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA) affects oxidative stress and the antioxidant defence system and may improve the levels of some relevant inflammatory, and cardiovascular biomarkers in frail adults over fifty years of age and in elderly subjects. Fifty-five patients were divided into two groups and were exclusively fed a newly designed normoproteic and isocaloric enteral formula enriched with eicosapentaenoic (98 mg/d) and docosahexaenoic acids (46 mg/d) (n = 26) or a reference enteral diet (n = 29). Oxidative, inflammatory and cardiovascular risk biomarkers and red blood cell fatty acid profiles were determined at the beginning and after 90 and 180 days of feeding. The n-3 LC-PUFA percentage tended to be higher (P = 0.053) in the experimental group than in the reference group. Administration of the n-3 LC-PUFA diet did not increase oxidative stress or modify plasma antioxidant capacity but decreased antioxidant enzymatic activities. MMP-9 plasma concentration decreased with both formulae, whereas tPAI-1 tended to decrease (P = 0.116) with the administration of the experimental formula. In conclusion, administration of the new n-3 LC-PUFA-enriched product for 6 months did not negatively alter the oxidative status and improved some cardiovascular risk biomarkers. PMID:26697137

  15. 18 CFR 367.80 - Supervision and engineering.

    Science.gov (United States)

    2010-04-01

    ... engineering. 367.80 Section 367.80 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... ACT Operating Expense Instructions § 367.80 Supervision and engineering. (a) The supervision and engineering includible in the operating expense accounts must consist of the pay and expenses...

  16. 33 CFR 80.1144 - Bodega and Tomales Bay, CA.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Bodega and Tomales Bay, CA. 80.1144 Section 80.1144 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1144 Bodega and Tomales Bay, CA. (a) An east-west line drawn from Sand...

  17. The bone mass density in men aged over 50 and its relation to the concentration of free and total testosterone in the blood serum

    International Nuclear Information System (INIS)

    As the mean length of life increases, osteoporosis affects a growing number of men and women, thus becoming an important medical and socioeconomic problem in many countries. Pathogenesis and the prevalence of the osteoporosis in women are well established, however, in men, they are still controversial. In this study, the bone mass density (BMD) of the lumbar spine was determined in 100 healthy men age 50-83, using quantitative computed tomography (QCT). Also, the total serum and free testosterone was measured. The mean BMD was 123.1I39.3 mg/cm3, and the values below a fracture threshold were noted in 39% of subjects. The mean concentration of total and free serum testosterone was 4.3I1.7 ng/ml and 6.2I3.7 pg/ml, respectively. There was a significant (p3, respectively). There was no correlation found between total testosterone and BMD. Results indicate that reduced bone mass density in males over 50 is as frequent as recently reported in females. Moreover, sex hormones seem to be related to osteoporosis development in men as well. (author)

  18. Surgical treatment of interrupted aortic arch associated with ventricular septal defect and patent ductus arteriosus in patients over one year of age

    Institute of Scientific and Technical Information of China (English)

    Li Zhiqiang; Li Bin; Fan Xiangming; Su Junwu; Zhang Jing; He Yan; Liu Yinglong

    2014-01-01

    Background Interrupted aortic arch (IAA) is a rare congenital anomaly affecting 1.5% of infants with congenital heart disease.Neonatal repair of IAA is required to avoid irreversible pulmonary vascular lesion.However,in China,patients with IAA associated with ventricular septal defect (VSD) and patent ductus arteriosus (PDA) over one year of age are common.So we investigated the outcome of surgical treatment of IAA with VSD and PDA in patients over one year of age.Methods From January 2009 to December 2012,19 patients with IAA have undergone complete single-stage repair.The patients' mean age was 4.4 years,ranging 1 to 15 years; and their mean weight was 12.8 kg,ranging 4.2 to 36.0 kg.Fifteen IAA were type A,four were type B.Preoperative cardiac catheterization data were available from all patients.Mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR) were measured.The measurements of postoperative pulmonary artery pressure were taken in the operating room at the end of the case.All patients underwent echocardiographic examinations before discharged from the hospital.In addition,cardiac catheterization and echocardiographic examinations were performed during follow-up.Selective brain perfusion through the innominate artery during aortic arch reconstruction was used in all patients.Mean follow-up was (1.6±0.8) years.Results There were two hospital deaths (2/19,11%).One patient died of pulmonary hypertension crisis,and another died of postoperative low cardiac output.Five cases had other main postoperative complications but no postoperative neurologic complications.Seventeen survivors were followed up,and there were no late deaths or reoperation.Mean cross-clamp duration was (85±22) minutes and selective brain perfusion duration was (34±11) minutes.Two patients required delayed sternal closure at two days postoperatively.Intensive care unit and hospital stays were (9±8) days and (47±24) days,respectively.Pressure gradients across

  19. 48 CFR 852.236-80 - Subcontracts and work coordination.

    Science.gov (United States)

    2010-10-01

    ... coordination. 852.236-80 Section 852.236-80 Federal Acquisition Regulations System DEPARTMENT OF VETERANS....236-80 Subcontracts and work coordination. As prescribed in 836.574, insert the following clause: Subcontracts and Work Coordination (APR 1984) (a) Nothing contained in this contract shall be construed...

  20. 47 CFR 80.417 - FCC Rules and Regulations.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false FCC Rules and Regulations. 80.417 Section 80... STATIONS IN THE MARITIME SERVICES Station Documents § 80.417 FCC Rules and Regulations. The Commission's... available on the Commission's web site at www.fcc.gov or ftp.fcc.gov....

  1. The aging population: demographics and the biology of aging.

    Science.gov (United States)

    Kanasi, Eleni; Ayilavarapu, Srinivas; Jones, Judith

    2016-10-01

    Epidemiologic studies show that 11% of the world's population is over 60 years of age; this is projected to increase, by 2050, to 22% of the population. Oral aging is a current focus of several organizations including the Federation Dentaire Internationale, the World Health Organization and the American and Japanese Dental Associations. In their Tokyo Declaration, the Japanese Association identified the elderly population as one of its main target groups. One of the WHO goals is for each person to retain more than 20 teeth by age 80, despite the fact that the prevalence of periodontal disease is continuously rising as the population is aging. Every species has its own characteristic lifespan, which is determined by its evolutionary history and is modified by multiple diverse factors, including biological mechanisms. In humans, the gradual accumulation of products of cellular metabolism and extensive DNA damage contribute to the aging process. Aging is thought to be associated with a low-grade inflammatory phenotype in mammals, called 'inflammaging', and is the result of autophagic capacity impairing so-called 'housekeeping activities' in the cells, resulting in protein aggregation, mitochondrial dysfunction and oxidative stress. Delayed stem-cell proliferation, associated with aging, may impact the maintenance and survival of a living being, but excessive proliferation could also result in depleted reserves of stem cells. Studies are needed to address the association of delayed cell proliferation and wound healing with the onset of periodontal diseases and response to treatment. The effects of systemic diseases, medications, psychological effects and decreased interest or ability in performing oral-hygiene practices are thought to result in periodontal diseases, and ultimately in tooth loss, in aged individuals. Together with an aging population comes a responsibility for 'healthy' and 'successful' aging. This article describes the changing global demographic

  2. Low prevalence of pneumococcal carriage and high serotype and genotype diversity among adults over 60 years of age living in Portugal.

    Directory of Open Access Journals (Sweden)

    Sónia T Almeida

    Full Text Available Pneumococcal disease is frequent at the extremes of age. While several studies have looked at colonization among young children, much less is known among the elderly. We aimed to evaluate pneumococcal carriage among elderly adults living in Portugal. Between April 2010 and December 2012, nasopharyngeal and oropharyngeal swabs of adults over 60 years of age, living in an urban area (n = 1,945 or in a rural area (n = 1,416, were obtained. Pneumococci were isolated by culture-based standard procedures, identified by optochin susceptibility, bile solubility and PCR screening for lytA and cpsA, and characterized by antibiotype, serotype, and MLST. Associations between pneumococcal carriage, socio-demographic and clinical characteristics were evaluated by univariate analysis and multiple logistic regression. The global prevalence of carriage was 2.3% (95% CI: 1.8-2.8. In the multiple logistic regression analysis, smoking, being at a retirement home, and living in a rural area increased the odds of being a pneumococcal carrier by 4.4-fold (95% CI: 1.9-9.2, 2.0-fold (95% CI: 1.1-3.6 and 2.0-fold (95% CI: 1.2-3.5, respectively. Among the 77 pneumococcal isolates, 26 serotypes and 40 STs were identified. The most prevalent serotypes were (in decreasing order 19A, 6C, 22F, 23A, 35F, 11A, and 23B, which accounted, in total, for 60.0% of the isolates. Most isolates (93.5% had STs previously described in the MLST database. Resistance to macrolides, non-susceptibility to penicillin and multidrug resistance were found in 19.5%, 11.7%, and 15.6% of the isolates, respectively. We conclude that the prevalence of pneumococcal carriage in the elderly, in Portugal, as determined by culture-based methods, is low. Serotype and genotype diversity is high. Living in a rural area, in a retirement home, and being a smoker increased the risk of pneumococcal carriage. This study contributes to the establishment of a baseline that may be used to monitor how novel

  3. Do Sources of Cigarettes among Adolescents Vary by Age over Time?

    Science.gov (United States)

    Lenk, Kathleen M.; Toomey, Traci L.; Shi, Qun; Erickson, Darin J.; Forster, Jean L.

    2014-01-01

    Trends in sources of cigarettes among adolescents were assessed using data from a teen cohort (2000-2006). Five sources--bought from store, got from other teen, stole from others, bought from others, and got from an adult--were measured over time by age. The most common source among all ages was other teens. Fewer teens bought cigarettes from…

  4. Age-related self-overestimation of step-over ability in healthy older adults and its relationship to fall risk

    OpenAIRE

    Sakurai, Ryota; Fujiwara, Yoshinori; Ishihara, Masami; Higuchi, Takahiro; Uchida, Hayato; Imanaka, Kuniyasu

    2013-01-01

    Background Older adults could not safely step over an obstacle unless they correctly estimated their physical ability to be capable of a successful step over action. Thus, incorrect estimation (overestimation) of ability to step over an obstacle could result in severe accident such as falls in older adults. We investigated whether older adults tended to overestimate step-over ability compared with young adults and whether such overestimation in stepping over obstacles was associated with fall...

  5. Gender-Specific Associations between Perceived Neighbourhood Walkability and Meeting Walking Recommendations When Walking for Transport and Recreation for Czech Inhabitants over 50 Years of Age

    Directory of Open Access Journals (Sweden)

    Jana Pelclová

    2013-12-01

    Full Text Available Few studies have investigated the different effects that the built environment may have on the physical activity behaviours of men and women. Therefore, the aim of this study was to estimate the gender differences in meeting walking recommendations in relation to perceived neighbourhood walkability attributes within the active transportation and leisure-time domains for Czech inhabitants over 50 years of age. The sample included 1,417 men and 1,422 women who were randomly selected. The Abbreviated Neighbourhood Environment Walkability Scale (ANEWS was used to obtain information about the perceived environment. The self-administered long version of the IPAQ was used to assess physical activity levels. When walking for transport, men living in neighbourhoods with high street connectivity (OR = 1.47, CI = 1.04–2.9 and higher traffic and crime safety (OR = 1.28, CI = 1.02–1.6 and women living in neighbourhoods with high proximity (OR = 1.36, CI = 1.04–1.77 and high neighbourhood aesthetics (OR = 1.36, CI = 1.04–1.76 were more likely to meet recommended levels of walking. No environmental attributes were found to significantly influence the accomplishment of walking recommendations by men or women when walking for leisure. The study results indicate the gender-specific associations between transportation-related walking and the environment factors. The consideration of those factors in the design of gender-specific walking interventions for Czech inhabitants may help the interventions to be more effective in promotion of physical activity.

  6. Gender-specific associations between perceived neighbourhood walkability and meeting walking recommendations when walking for transport and recreation for Czech inhabitants over 50 years of age.

    Science.gov (United States)

    Pelclová, Jana; Frömel, Karel; Cuberek, Roman

    2013-12-30

    Few studies have investigated the different effects that the built environment may have on the physical activity behaviours of men and women. Therefore, the aim of this study was to estimate the gender differences in meeting walking recommendations in relation to perceived neighbourhood walkability attributes within the active transportation and leisure-time domains for Czech inhabitants over 50 years of age. The sample included 1,417 men and 1,422 women who were randomly selected. The Abbreviated Neighbourhood Environment Walkability Scale (ANEWS) was used to obtain information about the perceived environment. The self-administered long version of the IPAQ was used to assess physical activity levels. When walking for transport, men living in neighbourhoods with high street connectivity (OR = 1.47, CI = 1.04-2.9) and higher traffic and crime safety (OR = 1.28, CI = 1.02-1.6) and women living in neighbourhoods with high proximity (OR = 1.36, CI = 1.04-1.77) and high neighbourhood aesthetics (OR = 1.36, CI = 1.04-1.76) were more likely to meet recommended levels of walking. No environmental attributes were found to significantly influence the accomplishment of walking recommendations by men or women when walking for leisure. The study results indicate the gender-specific associations between transportation-related walking and the environment factors. The consideration of those factors in the design of gender-specific walking interventions for Czech inhabitants may help the interventions to be more effective in promotion of physical activity.

  7. Health coaching and pedometers to enhance physical activity and prevent falls in community-dwelling people aged 60 years and over: study protocol for the Coaching for Healthy AGEing (CHAnGE) cluster randomised controlled trial

    OpenAIRE

    Tiedemann, Anne; Rissel, Chris; Howard, Kirsten; Tong, Allison; Merom, Dafna; Smith, Stuart; WICKHAM, JAMES; Bauman, Adrian; Lord, Stephen R; Vogler, Constance; Lindley, Richard I; Simpson, Judy M; Allman-Farinelli, Margaret; Sherrington, Catherine

    2016-01-01

    Introduction Prevention of falls and promotion of physical activity are essential for maximising well-being in older age. However, there is evidence that promoting physical activity among older people without providing fall prevention advice may increase fall rates. This trial aims to establish the impact of a physical activity and fall prevention programme compared with a healthy eating programme on physical activity and falls among people aged 60+ years. Methods and analysis This cluster ra...

  8. [Distribution of the different patterns of aging over the system of animal world].

    Science.gov (United States)

    Popov, I Iu

    2011-01-01

    Since the system of animal world reflects evolutionary trends, an analysis of distribution of patterns of aging over this system provides information on the causes of the formation of differences among them. In this paper the system of the main animal groups in form of a table is presented, and the distribution of patterns demonstrating minimum and maximum of aging is discussed. Meanwhile the colonial animals are considered as a "minimum of aging", the animals demonstrating drastic self-liquidation after reproduction are considered as a "maximum of aging" (the most well-known example is the pink salmon). It is shown, that as far as the degree of difference from the simplest ancestor increases in process of evolution, the increase of the manifestations of aging takes place. Slow aging of relatively simple organisms cannot be a direct source of measures to prevent aging of complex ones. PMID:21957572

  9. Attitudes towards breast conservation in patients aged over 70 with breast cancer

    OpenAIRE

    Smith, L. I.; Dayal, S.; Murray, J; Lannigan, A

    2016-01-01

    Background The majority of breast conserving surgery (BCS) is performed in younger women. There is little published information about the views of women aged over 70 regarding BCS. The aim of this study was to investigate the attitudes of this age group towards BCS, and factors which may influence their treatment decision-making. Methods A questionnaire was sent to all patients who were aged 70 or over at the time they had breast cancer surgery in NHS Lanarkshire between 1999 and 2013. This d...

  10. Eye of the storm : Enbridge's Michigan leak and debate over the integrity of North America's sprawling network of aging pipelines

    Energy Technology Data Exchange (ETDEWEB)

    Stastny, R.P.

    2010-10-15

    In the aftermath of Enbridge's oil spill in Michigan from a pipe break, the company may face greater scrutiny in its Northern Gateway application for a pipeline crossing British Columbia to the coast, where tankers would ship Alberta bitumen to Asia. In addition, regulators in the United States are more likely to be more diligent regarding TransCanada's Keystone pipeline expansion and extension to the U.S. Gulf Coast, where refineries wait to process Canadian bitumen. The Enbridge spill has sparked a debate over the integrity of North America's aging pipelines. Operators claim that transmission pipelines can operate for an indefinite period of time, provided that the appropriate maintenance and inspection practices are used. Repairs can include outright replacement of corroded pipe sections or less demanding in-situ repairs to damaged pipe coatings or cathode replacement. Coatings and cathodic protection protects pipelines from the external environment. Pigging and chemicals prevent internal corrosion from water, carbon dioxide, hydrogen sulphide, chlorines and other residues. Despite these maintenance and repair efforts, many of the pipes currently in the ground were engineered for a useful life of 20 or 25 years. 6 figs.

  11. Drinking Over the Lifespan: Focus on College Ages.

    Science.gov (United States)

    Merrill, Jennifer E; Carey, Kate B

    2016-01-01

    Many college students drink heavily and experience myriad associated negative consequences. This review suggests that a developmental perspective can facilitate a better understanding of college drinking. Specifically, using an emerging adulthood framework that considers the ongoing role of parents and neurodevelopmental processes can provide insight into why students drink. Most college students drink and tend to drink more and more heavily than their non-college-attending peers. These drinking patterns are affected by environmental and temporal characteristics specific to the college environment, including residential campus living, the academic week, and the academic year. Additional psychosocial factors are of particular relevance to the drinking behavior of college-age people, and include exaggerated peer norms, the development and use of protective behavioral strategies, and mental health considerations. Understanding the unique interaction of person and environment is key to designing prevention/intervention efforts. PMID:27159817

  12. Ageing and skills

    DEFF Research Database (Denmark)

    Desjardins, Richard; Warnke, Arne Jonas

    of countries. Specifically, repeated measures will enable an analysis of whether there is skill gain and skill loss over the lifespan of cohorts and overtime between cohorts. This is especially important because age-skill profiles observed on the basis of a single cross-section are difficult to interpret....... With this as a backdrop, this paper has sought to provide an overview of what is known about age-skill profiles and to conduct an analysis that demonstrates how trend data based on repeated cross-sectional observations of direct measures of skill at the cohort level can be used to estimate skill gain and skill loss over...

  13. The comparison between measurement of open apices of third molars and Demirjian stages to test chronological age of over 18 year olds in living subjects.

    Science.gov (United States)

    Cameriere, R; Ferrante, L; De Angelis, D; Scarpino, F; Galli, F

    2008-11-01

    This paper concerns a method for assessing adult age based on the relationship between age and the third molar maturity index (I(3M)), which is related to the measurement of the open apices of the third molar. Furthermore, this method was compared to those based on Demirjian's stages G and H. The sample consisted of 906 Caucasian individuals aged between 14 and 23 years (53.6% females and 46.4% males). Orthopantomographs were analyzed by two observers and calibrated by means of the concordance correlation coefficient for the reproducibility of the third molar maturity index (I(3M)) and kappa statistics for reproducibility of the Demirjian stages. Probabilities for an individual to be older than 18 years of age (adult age) were derived using the measurements of the third molar maturity index (I(3M)). These results were exploited to set out a threshold value to assign an individual to juvenile or adult age. A cutoff value of I(3M) = 0.08 was taken. The sensitivity of this test was 70% and specificity was 98%. Furthermore, the proportion of individuals with a correct classification was 83%. The results of the test showed a better specificity when compared to the choice of stage G and a better sensitivity when compared to the choice of stage H for adult age.

  14. Student characteristics and behaviors at age 12 predict occupational success 40 years later over and above childhood IQ and parental socioeconomic status.

    Science.gov (United States)

    Spengler, Marion; Brunner, Martin; Damian, Rodica I; Lüdtke, Oliver; Martin, Romain; Roberts, Brent W

    2015-09-01

    Drawing on a 2-wave longitudinal sample spanning 40 years from childhood (age 12) to middle adulthood (age 52), the present study was designed to examine how student characteristics and behaviors in late childhood (assessed in Wave 1 in 1968) predict career success in adulthood (assessed in Wave 2 in 2008). We examined the influence of parental socioeconomic status (SES), childhood intelligence, and student characteristics and behaviors (inattentiveness, school entitlement, responsible student, sense of inferiority, impatience, pessimism, rule breaking and defiance of parental authority, and teacher-rated studiousness) on 2 important real-life outcomes (i.e., occupational success and income). The longitudinal sample consisted of N = 745 persons who participated in 1968 (M = 11.9 years, SD = 0.6; 49.9% female) and 2008 (M = 51.8 years, SD = 0.6; 53.3% female). Regression analyses and path analyses were conducted to evaluate the direct and indirect effects (via education) of the predictors on career success. The results revealed direct and indirect influences of student characteristics (responsible student, rule breaking and defiance of parental authority, and teacher-rated studiousness) across the life span on career success after adjusting for differences in parental SES and IQ at age 12. rd PMID:26147775

  15. Stress, Aging and Thirst

    Science.gov (United States)

    Greenleaf, John E.

    1998-01-01

    After growth during adolesence, total body water decreases progressively with aging from 65% of body weight to about 53% of body weight in the 70th decade; a majority of the loss occurs from the extracellular volume, from 42% to about 25%, respectively. Cellular volume also reaches equilibrium in the 70th decade at about 25% of body weight. Various stresses such as exercise, heat and attitude exposure, ad prior dehydration attenuate voluntary fluid intake (involuntary dehydration). Voluntary fluid intake appears to decrease with aging (involuntary dehydration in this sense aging can be considered as a stress. Kidney function and muscle mass (80% water) decrease somewhat with aging, and voluntary fluid intake (thirst) is also attenuated. Thirst is stimulated by increasing osmolality (hypernatremia) of the extracellular fluid and by decreased extracellular volume (mainly plasma volume) which act to increase intracellular fluid volume osmolality to activiate drinking. The latter decreases fluid compartment osmolality which ' It terminates drinking. However, this drinking mechanism seems to be attenuated with aging such that increasing plasma osmolality no longer stimulates fluid intake appropriately. Hypernatremia in the elderly has been associated all too frequently with greater incidence of bacterial infection and increased mortality. Involuntary dehydration can be overcome in young men by acclimation to an intermittent exercise-in-heat training program. Perhaps exercise training in the elderly would also increase voluntary fluid intake and increase muscle mass to enhance retention of water.

  16. 腔内修复术治疗80岁以上肾下腹主动脉瘤患者的有效性和安全性分析%Efficacy and safety analysis of endovascular aortic repair of abdominal aortic aneurysms in patients over eighty years old

    Institute of Scientific and Technical Information of China (English)

    王志浩; 段琛; 吴忠隐; 张宏鹏; 熊江; 马晓辉; 刘小平; 郭伟; 刘杰; 贾鑫; 贾森皓; 张敏宏; 孙国义; 冯燕; 裴楠楠; 张佳

    2016-01-01

    Objective To evaluate the outcome of the endovascular aortic repair ( EVAR ) of abdominal aortic aneurysms (AAA) in patients over 80 years old and analyze the factors that influence its long-term curative effect.Methods Follow-up visits and analysis were conducted from January 2004 to December 2013 on a total of 96 AAA patients aged over 80 years old who had been treated with EVAR and thus met the inclusion criteria.The primary focus of the study was all-cause mortality and secondary focuses included the rate of intervention-related complications, the rate of secondary interventions and procedural data.The Kaplan-Meier survival curve was used to analyze the long-term survival rate and the cumulative probability of intervention-related complications.The Cox proportional hazards regression model was used to analyze factors that could influence the long-term survival rate.Results Effective follow-up visits were conducted on 76 patients ( 79.2%).The patients were tracked for an average of 3.63 years, with the longest follow-up lasting 10.34 years.During the study, 27 deaths occurred and the all-cause mortality rate was 28.1%.Furthermore, 8 cases of intervention-related complications (8.3%) were observed, including endoleaks and spinal cord ischemia.A total of 6 secondary interventions were conducted on 6 patients, with the rate of secondary interventions being 6.3%.The five-year cumulative survival rate was 64% ( 95%CI:0.53-0.78 ) and the ten-year cumulative survival rate was 35%( 95%CI: 0.15 -0.84 ).The Cox proportional hazards model showed that an ASA classification ofⅢ/Ⅳ(HR=8.45,95%CI:1.26-56.55, P<0.05), smoking (HR=2.08,95%CI:0.70-2.63,P<0.05) and cerebrovascular diseases (HR=2.96,95%CI:1.06 -8.25, P <0.05 ) could significantly increase the risk of the long-term all-cause mortality of an AAA patient treated with EVAR.While hypertension could significantly decrease the risk (HR=0.25,95%CI:0.10-0.66, P<0.05).Conclusion EVAR is safe for senior patients with AAA

  17. Tween-80 and impurity induce anaphylactoid reaction in zebrafish.

    Science.gov (United States)

    Yang, Rui; Lao, Qiao-Cong; Yu, Hang-Ping; Zhang, Yong; Liu, Hong-Cui; Luan, Lin; Sun, Hui-Min; Li, Chun-Qi

    2015-03-01

    A number of recent reports suspected that Tween-80 in injectable medicines, including traditional Chinese medicine injections could cause life-threatening anaphylactoid reaction, but no sound conclusion was drawn. A drug-induced anaphylactoid reaction is hard to be assayed in vitro and in conventional animal models. In this study, we developed a microplate-based quantitative in vivo zebrafish assay for assessing anaphylactoid reaction and live whole zebrafish mast cell tryptase activity was quantitatively measured at a wavelength of 405 nm using N-benzoyl-dl-arginine p-nitroanilide as a substrate. We assessed 10 batches of Tween-80 solutions from various national and international suppliers and three Tween-80 impurities (ethylene glycol, 2-chloroethanol and hydrogen peroxide) in this model and found that three batches of Tween-80 (nos 2, 20080709 and 20080616) and one Tween-80 impurity, hydrogen peroxide (H2 O2 ), induced anaphylactoid reactions in zebrafish. Furthermore, we found that H2 O2 residue and peroxide value were much higher in Tween-80 samples 2, 20080709 and 20080616. These findings suggest that H2 O2 residue in combination with oxidized fatty acid residues (measured as peroxide value) or more likely the oxidized fatty acid residues in Tween-80 samples, but not Tween-80 itself, may induce anaphylactoid reaction. High-throughput zebrafish tryptase assay developed in this report could be used for assessing safety of Tween-80-containing injectable medicines and potentially for screening novel mast cell-modulating drugs. PMID:25345596

  18. A Longitudinal Metric Analysis of Course-subjects to reveal the Evolution of a Discipline: Changes in the Teaching Frequency and Ratio of Courses in Law Schools in the United States over 80 years

    Directory of Open Access Journals (Sweden)

    Peter A. Hook

    2016-06-01

    Full Text Available This article is a longitudinal, metric analysis of law school course-subjects in the United States. Its data source is the lists of “teachers by subject” contained in the annual directories of the American Association of Law Schools for a total of 57,915 data points. The number of faculty teaching the various course-subjects is compared for three time periods: (1 1931–1932, (2 1972–1973, and (3 2010–2011. The course-subjects are a controlled vocabulary. In addition, the mergence and divergence of course-subjects are noted based on the timing of changes, “includes” statements, and “see also” references. This allows meaningful comparisons across time to reveal which coursesubjects and groups of related course-subjects are rising and falling in importance in the legal academy in the United States. Topics such as International Law, Constitutional Law, and Legal Research and Writing have gained the most in terms of the percentage number of teachers teaching these topics. Topics such as Estate Planning, Commercial Law, and Business Associations have lost the most in terms of the percentage number of teachers teaching these topics. In addition, the course-subjects with the highest and lowest average of the length of time they have been taught are reported for each period.

  19. The true value of Lambda appear to be nonzero and not constant with age : participation and frequency during criminal careers over the life span

    NARCIS (Netherlands)

    Petras, H.; Nieuwbeerta, P.; Piquero, A.

    2010-01-01

    Recent advances and debates surrounding general/developmental and static/dynamic theories of crime can be traced to the 1986 National Academy of Science Report on criminal careers and the discussion it generated. A key point of contention lies in the interpretation of the age-crime curve. For Gottfr

  20. CO2 capture at low temperatures (30-80 °C) and in the presence of water vapor over a thermally activated Mg-Al layered double hydroxide.

    Science.gov (United States)

    Torres-Rodríguez, Daniela A; Lima, Enrique; Valente, Jaime S; Pfeiffer, Heriberto

    2011-11-10

    The carbonation process of a calcined Mg-Al layered double hydroxide (LDH) was systematically analyzed at low temperatures, varying the relative humidity. Qualitative and quantitative experiments were performed. In a first set of experiments, the relative humidity was varied while maintaining a constant temperature. Characterization of the rehydrated products by thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR) and solid-state NMR revealed that the samples did not recover the LDH structure; instead hydrated MgCO(3) was produced. The results were compared with similar experiments performed on magnesium oxide for comparison purposes. Then, in the second set of experiments, a kinetic analysis was performed. The results showed that the highest CO(2) capture was obtained at 50 °C and 70% of relative humidity, with a CO(2) absorption capacity of 2.13 mmol/g. PMID:21936518

  1. Efficient regenerative wavelength conversion at 10Gbit/s over C- and L-band (80nm span) using a Mach-Zehnder interferometer with monolithically integrated semiconductor optical amplifiers

    DEFF Research Database (Denmark)

    Dülk, M.; Fischer, St.; Gamper, E.;

    2000-01-01

    A demonstration is presented of 10Gbit/s 2R regenerative wavelength up- and down-conversion within the C-band as well as up-conversion to the L-band using a monolithically integrated Mach-Zehnder interferometer module with semiconductor optical amplifiers (MZI-SOAs). The converted output signals ...

  2. 高龄双胎妊娠的围产结局分析%Perinatal outcomes in women aged 35 and over with twin pregnancy

    Institute of Scientific and Technical Information of China (English)

    陈敏玲; 王子莲; 凌家炜; 韩振艳

    2010-01-01

    目的 探讨高龄双胎妊娠的围产结局.方法 回顾性分析我院69例高龄双胎病例,随机对照176例非高龄双胎的临床资料,比较两组在妊娠并发症、妊娠合并症、和胎儿预后等方面的差异.结果 ①高龄组接受辅助生育技术受孕比例显著高于非高龄对照组(P<0.05);②高龄组<32孕周早产发生率明显高于对照组(P<0.05),而其他并发症及合并症两组间未见显著性差异;③高龄组以极低出生体重儿(<1500 g)比例显著高于对照组(P<0.05).高龄组新生儿窒息率及胎儿窘迫发生率明显增高(P<0.05).结论 高龄双胎妊娠不良妊娠结局主要与<32孕周的严重早产、极低体重儿、新生儿窒息及胎儿窘迫密切相关,应针对性加强高龄双胎的围生期监护,警惕严重早产的发生.%Objective The aim of this study is to present perinataloutcomes of twin gestations in older women. Methods We conducted a retrospective cohort study of 69 cases of twin pregnancies maternal age 35 years and older( study group)in our department, compared with 176 twin pregnancies cases of maternal age less than 35 years( control group). Results ①Conceptions after assisted reproductive technology were significantly higher in study group(P<0.05 ). ②The rate of preterm labour lower than 32 gestational weeks was significantly higher in the study group(P<0.05). The other complications rate did not differ singnificantly from the control groups. (3) The very low birth weight ( VLBW < 1,500 g) rate was significantly higher in the study group ( P<0.05 ), the rate of neonatal asphyxia and fetal distress were statistically significant higher in study group (P<0.05). Conclusion Advanced maternal age was related with higher incidence of the severe preterm labour(<32 gestational weeks) ,the very low birth weight(<1,500 g) ,fetal distress,neonatal asphyxia. It is important to close monitoring during perinatal period in women aged 35 and

  3. Immunogenicity and reactogenicity of a recombinant hepatitis B vaccine in subjects over age of forty years and response of a booster dose among nonresponders

    OpenAIRE

    Das, Kunal; Gupta, R.K.; Kumar, V.; Kar, P.

    2003-01-01

    AIM: The study was initiated to evaluate the reactogenicity and immunogenicity of a recombinant hepatitis B vaccine in age group > 40 years and to study the response of a single booster dose in primary non-responders to the hepatitis B vaccination.

  4. Subliminal strengthening: improving older individuals' physical function over time with an implicit-age-stereotype intervention.

    Science.gov (United States)

    Levy, Becca R; Pilver, Corey; Chung, Pil H; Slade, Martin D

    2014-12-01

    Negative age stereotypes that older individuals assimilate from their culture predict detrimental outcomes, including worse physical function. We examined, for the first time, whether positive age stereotypes, presented subliminally across multiple sessions in the community, would lead to improved outcomes. Each of 100 older individuals (age=61-99 years, M=81) was randomly assigned to an implicit-positive-age-stereotype-intervention group, an explicit-positive-age-stereotype-intervention group, a combined implicit- and explicit-positive-age-stereotype-intervention group, or a control group. Interventions occurred at four 1-week intervals. The implicit intervention strengthened positive age stereotypes, which strengthened positive self-perceptions of aging, which, in turn, improved physical function. The improvement in these outcomes continued for 3 weeks after the last intervention session. Further, negative age stereotypes and negative self-perceptions of aging were weakened. For all outcomes, the implicit intervention's impact was greater than the explicit intervention's impact. The physical-function effect of the implicit intervention surpassed a previous study's 6-month-exercise-intervention's effect with participants of similar ages. The current study's findings demonstrate the potential of directing implicit processes toward physical-function enhancement over time.

  5. 47 CFR 80.1109 - Distress, urgency, and safety communications.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Distress, urgency, and safety communications. 80.1109 Section 80.1109 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Global Maritime Distress and Safety System...

  6. Cardiovascular Risk in Men Aged Over 40 in Boa Vista, Brazil

    OpenAIRE

    Mário Maciel de Lima; Emanuel Araújo Bezerra; José Geraldo Ticianeli

    2016-01-01

    Background: Cardiovascular disease is the most common cause of disease in the developed world. Early detection and risk prediction are a key component in reducing cardiovascular mortality. The Framingham Risk Score uses age, sex, cholesterol, blood pressure, diabetes, and smoking to calculate the 10-year risk probability of developing cardiovascular disease for a given patient. The aim of this study was to examine cardiovascular disease risk in men aged over 40 years in Boa Vista, Brazil and ...

  7. Cardiovascular risk in men aged over 40 in Boa Vista, Brazil

    Directory of Open Access Journals (Sweden)

    Mário Maciel de Lima

    2016-01-01

    Conclusions: Our study highlights a worrying trend in increasing obesity and hypertension, most likely associated with increasingly poor diet and reduced participation in exercises. As the Brazilian population ages, this will drive increasing rates of cardiovascular mortality unless these trends are reversed. This study suggests that such campaigns should focus on men over the age of 40, who are married or divorced and of lower income.

  8. 47 CFR 80.1153 - Station log and radio watches.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Station log and radio watches. 80.1153 Section... SERVICES STATIONS IN THE MARITIME SERVICES Voluntary Radio Installations General § 80.1153 Station log and radio watches. (a) Licensees of voluntary ships are not required to maintain radio station logs....

  9. Transitions in cognitive test scores over 5 and 10 years in elderly people: Evidence for a model of age-related deficit accumulation

    Directory of Open Access Journals (Sweden)

    Rockwood Kenneth

    2008-02-01

    Full Text Available Abstract Background On average, health worsens with age, but many people have periods of improvement. A stochastic model provides an excellent description of how such changes occur. Given that cognition also changes with age, we wondered whether the same model might also describe the accumulation of errors in cognitive test scores in community-dwelling older adults. Methods In this prospective cohort study, 8954 older people (aged 65+ at baseline from the Canadian Study of Health and Aging were followed for 10 years. Cognitive status was defined by the number of errors on the 100-point Modified Min-Mental State Examination. The error count was chosen to parallel the deficit count in the general model of aging, which is based on deficit accumulation. As with the deficit count, a Markov chain transition model was employed, with 4 parameters. Results On average, the chance of making errors increased linearly with the number of errors present at each time interval. Changes in cognitive states were described with high accuracy (R2 = 0.96 by a modified Poisson distribution, using four parameters: the background chance of accumulating additional errors, the chance of incurring more or fewer errors, given the existing number, and the corresponding background and incremental chances of dying. Conclusion The change in the number of errors in a cognitive test corresponded to a general model that also summarizes age-related changes in deficits. The model accounts for both improvement and deterioration and appears to represent a clinically relevant means of quantifying how various aspects of health status change with age.

  10. Sociodemographic and Lifestyle Statistics of Oldest Old People (>80 Years Living in Ikaria Island: The Ikaria Study

    Directory of Open Access Journals (Sweden)

    Demosthenes B. Panagiotakos

    2011-01-01

    Full Text Available Background. There are places around the world where people live longer and they are active past the age of 100 years, sharing common behavioral characteristics; these places (i.e., Sardinia in Italy, Okinawa in Japan, Loma Linda in California and Nicoya Peninsula in Costa Rica have been named the “Blue Zones”. Recently it was reported that people in Ikaria Island, Greece, have also one of the highest life expectancies in the world, and joined the “Blue Zones”. The aim of this work work was to evaluate various demographic, lifestyle and psychological characteristics of very old (>80 years people participated in Ikaria Study. Methods. During 2009, 1420 people (aged 30+ men and women from Ikaria Island, Greece, were voluntarily enrolled in the study. For this work, 89 males and 98 females over the age of 80 yrs were studied (13% of the sample. Socio-demographic, clinical, psychological and lifestyle characteristics were assessed using standard questionnaires and procedures. Results. A large proportion of the Ikaria Study's sample was over the age of 80; moreover, the percent of people over 90 were much higher than the European population average. The majority of the oldest old participants reported daily physical activities, healthy eating habits, avoidance of smoking, frequent socializing, mid-day naps and extremely low rates of depression. Conclusion. Modifiable risk factors, such as physical activity, diet, smoking cessation and mid-day naps, might depict the “secrets” of the long-livers; these findings suggest that the interaction of environmental, behavioral together with clinical characteristics may determine longevity. This concept must be further explored in order to understand how these factors relate and which are the most important in shaping prolonged life.

  11. Sociodemographic and lifestyle statistics of oldest old people (>80 years) living in ikaria island: the ikaria study.

    Science.gov (United States)

    Panagiotakos, Demosthenes B; Chrysohoou, Christina; Siasos, Gerasimos; Zisimos, Konstantinos; Skoumas, John; Pitsavos, Christos; Stefanadis, Christodoulos

    2011-01-01

    Background. There are places around the world where people live longer and they are active past the age of 100 years, sharing common behavioral characteristics; these places (i.e., Sardinia in Italy, Okinawa in Japan, Loma Linda in California and Nicoya Peninsula in Costa Rica) have been named the "Blue Zones". Recently it was reported that people in Ikaria Island, Greece, have also one of the highest life expectancies in the world, and joined the "Blue Zones". The aim of this work work was to evaluate various demographic, lifestyle and psychological characteristics of very old (>80 years) people participated in Ikaria Study. Methods. During 2009, 1420 people (aged 30+) men and women from Ikaria Island, Greece, were voluntarily enrolled in the study. For this work, 89 males and 98 females over the age of 80 yrs were studied (13% of the sample). Socio-demographic, clinical, psychological and lifestyle characteristics were assessed using standard questionnaires and procedures. Results. A large proportion of the Ikaria Study's sample was over the age of 80; moreover, the percent of people over 90 were much higher than the European population average. The majority of the oldest old participants reported daily physical activities, healthy eating habits, avoidance of smoking, frequent socializing, mid-day naps and extremely low rates of depression. Conclusion. Modifiable risk factors, such as physical activity, diet, smoking cessation and mid-day naps, might depict the "secrets" of the long-livers; these findings suggest that the interaction of environmental, behavioral together with clinical characteristics may determine longevity. This concept must be further explored in order to understand how these factors relate and which are the most important in shaping prolonged life. PMID:21403883

  12. 7 CFR 984.80 - Books and other records.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Books and other records. 984.80 Section 984.80 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... a period of two years after the end of the marketing year in which the recorded transactions...

  13. Le vieillissement de la flotte pétrolière et les marées noires dans les années 80 Aging of the Oil Tanker Fleet and Major Oil Spills in the 1980s

    Directory of Open Access Journals (Sweden)

    Smets H.

    2006-11-01

    Full Text Available Le vieillissement de la flotte pétrolière au cours des années à venir pourrait entraîner un accroissement du nombre et du volume des marées noires. L'examen de divers scénarios de contraction de la flotte pétrolière et de mise hors service des navires âgés permet cependant de conclure que la fréquence et le volume des marées noires en 1990 ne devraient pas excéder de façon très sensible les valeurs observées actuellement et pourraient même être inférieurs. The aging of the oil tanker fleet in the years to come could result in an increase in the number and volume of major oil spills. However, an examination of different scenarios for reducing the tanker fleet and for deactivating the older ships leads to the conclusion that the frequency and volume of major oil spills in 1990 should not be appreciably greater than the levels now observed and even that they could be somewhat less.

  14. Epigenetics and aging

    Science.gov (United States)

    Pal, Sangita; Tyler, Jessica K.

    2016-01-01

    Over the past decade, a growing number of studies have revealed that progressive changes to epigenetic information accompany aging in both dividing and nondividing cells. Functional studies in model organisms and humans indicate that epigenetic changes have a huge influence on the aging process. These epigenetic changes occur at various levels, including reduced bulk levels of the core histones, altered patterns of histone posttranslational modifications and DNA methylation, replacement of canonical histones with histone variants, and altered noncoding RNA expression, during both organismal aging and replicative senescence. The end result of epigenetic changes during aging is altered local accessibility to the genetic material, leading to aberrant gene expression, reactivation of transposable elements, and genomic instability. Strikingly, certain types of epigenetic information can function in a transgenerational manner to influence the life span of the offspring. Several important conclusions emerge from these studies: rather than being genetically predetermined, our life span is largely epigenetically determined; diet and other environmental influences can influence our life span by changing the epigenetic information; and inhibitors of epigenetic enzymes can influence life span of model organisms. These new findings provide better understanding of the mechanisms involved in aging. Given the reversible nature of epigenetic information, these studies highlight exciting avenues for therapeutic intervention in aging and age-associated diseases, including cancer. PMID:27482540

  15. Epigenetics and aging.

    Science.gov (United States)

    Pal, Sangita; Tyler, Jessica K

    2016-07-01

    Over the past decade, a growing number of studies have revealed that progressive changes to epigenetic information accompany aging in both dividing and nondividing cells. Functional studies in model organisms and humans indicate that epigenetic changes have a huge influence on the aging process. These epigenetic changes occur at various levels, including reduced bulk levels of the core histones, altered patterns of histone posttranslational modifications and DNA methylation, replacement of canonical histones with histone variants, and altered noncoding RNA expression, during both organismal aging and replicative senescence. The end result of epigenetic changes during aging is altered local accessibility to the genetic material, leading to aberrant gene expression, reactivation of transposable elements, and genomic instability. Strikingly, certain types of epigenetic information can function in a transgenerational manner to influence the life span of the offspring. Several important conclusions emerge from these studies: rather than being genetically predetermined, our life span is largely epigenetically determined; diet and other environmental influences can influence our life span by changing the epigenetic information; and inhibitors of epigenetic enzymes can influence life span of model organisms. These new findings provide better understanding of the mechanisms involved in aging. Given the reversible nature of epigenetic information, these studies highlight exciting avenues for therapeutic intervention in aging and age-associated diseases, including cancer. PMID:27482540

  16. Oral Health and Aging

    Science.gov (United States)

    ... please turn JavaScript on. Feature: Oral Health and Aging Oral Health and Aging Summer 2016 Table of Contents Jerrold H. Epstein, ... they may need. Read More "Oral Health and Aging" Articles Oral Health and Aging / 4 Myths About ...

  17. The Age of Reason: Financial Decisions over the Life-Cycle with Implications for Regulation

    OpenAIRE

    Laibson, David I.; Agarwal, Sumit; Driscoll, John C.; Gabaix, Xavier

    2009-01-01

    Many consumers make poor financial choices and older adults are particularly vulnerable to such errors. About half of the population between ages 80 and 89 either has dementia or a medical diagnosis of “cognitive impairment without dementia.†We study lifecycle patterns in financial mistakes using a proprietary database that measures ten different types of credit behavior. Financial mistakes include suboptimal use of credit card balance transfer offers, misestimation of the value of one’...

  18. What should be the first-line treatment for unexplained infertility in women over 40 years of age - ovulation induction and IUI, or IVF?

    Science.gov (United States)

    Tsafrir, Avi; Simon, Alex; Margalioth, Ehud J; Laufer, Neri

    2009-01-01

    The tendency to postpone childbearing in developed countries and the relatively high rate of infertility in older women contribute to an increase in the portion of women aged 40 years and older opting for infertility treatments. The main factor for infertility in this group is oocyte senescence, but since this process does not have a specific diagnosis many of those will be classified as having 'unexplained infertility'. The efficacy of the traditional clinical approach for 'unexplained infertility' in older women is questionable. Reviewing the current literature, clomiphene citrate seems to be inefficient in this group of patients, while delivery rates of gonadotrophins and intrauterine insemination cycles are less than 5%. Although low in absolute terms, IVF is more efficient. The chance for delivery, however, diminishes with each year of age above 40. Therefore, after a short trial of gonadotrophins and intrauterine insemination, women aged 40-41 years should be quickly referred to IVF. At an older age, IVF is the primary treatment option. PMID:20034413

  19. Antibody persistence and immune memory 4 years post-vaccination with combined hepatitis A and B vaccine in adults aged over 40 years.

    Science.gov (United States)

    Chlibek, Roman; von Sonnenburg, Frank; Van Damme, Pierre; Smetana, Jan; Tichy, Petr; Gunapalaiah, Bhavyashree; Leyssen, Maarten; Jacquet, Jeanne-Marie

    2011-01-01

    Persistence of immune response was assessed in adults aged >40 years (N = 596) following primary vaccination with combined hepatitis A/B vaccine or concomitant monovalent hepatitis A and B vaccines. Anti-hepatitis A virus antibody responses persisted for at least 4 years regardless of the vaccine used, with anti-hepatitis B surface antibody responses higher and more sustained in subjects who received the combined hepatitis A/B vaccine. Response rates to an additional dose of the same vaccine(s) used for priming were high.

  20. Health screening - men age 65 and older

    Science.gov (United States)

    Health maintenance visit - men - over age 65; Physical exam - men - over age 65; Yearly exam - men - over age 65; Checkup - men - over age 65; Men's health - over age 65; Preventive care exam - men - over ...

  1. Skin Care and Aging

    Science.gov (United States)

    ... page please turn Javascript on. Skin Care and Aging How Aging Affects Skin Your skin changes with age. It ... if they bother you. See additional resources on aging skin, including information on treatment options, specific conditions, ...

  2. Trends in Breast Cancer Incidence Rates by Age and Stage at Diagnosis in Gharbiah, Egypt, over 10 Years (1999–2008)

    OpenAIRE

    Hirko, Kelly A; Soliman, Amr S.; Ahmed Hablas; Seifeldin, Ibrahim A.; Mohamed Ramadan; Mousumi Banerjee; Harford, Joe B.; Chamberlain, Robert M; Sofia D. Merajver

    2013-01-01

    Background. This study was undertaken to evaluate trends in breast cancer incidence in Egypt from 1999 to 2008 and to make projections for breast cancer occurrence for the years 2009–2015. Patients and Methods. We utilized joinpoint regression and average annual percent change (AAPC) measures with 95% confidence intervals (CI) to describe the trends in breast cancer incidence rates from the Gharbiah Cancer Registry by age and stage at diagnosis and to estimate expected breast cancer caseloads...

  3. Birth cohort differences in fluid cognition in old age: comparisons of trends in levels and change trajectories over 30 years in three population-based samples.

    Science.gov (United States)

    Karlsson, Peter; Thorvaldsson, Valgeir; Skoog, Ingmar; Gudmundsson, Pia; Johansson, Boo

    2015-03-01

    Later-born cohorts of older adults tend to outperform earlier born on fluid cognition (i.e., Flynn effect) when measured at the same chronological ages. We investigated cohort differences in level of performance and rate of change across three population-based samples born in 1901, 1906, and 1930, drawn from the Gerontological and Geriatric Population Studies in Gothenburg, Sweden (H70), and measured on tests of logical reasoning and spatial ability at ages 70, 75, and 79 years. Estimates from multiple-group latent growth curve models (LGCM) revealed, in line with previous studies, substantial differences in level of performance where later-born cohorts outperformed earlier born cohorts. Somewhat surprisingly, later-born cohorts showed, on average, a steeper decline than the earlier-born cohort. Gender and education only partially accounted for observed cohort trends. Men outperformed women in the 1906 and 1930 cohorts but no difference was found in the 1901 cohort. More years of education was associated with improved performance in all three cohorts. Our findings confirm the presence of birth cohort effects also in old age but indicate a faster rate of decline in later-born samples. Potential explanations for these findings are discussed.

  4. Short-term blood pressure variability over 24 h and target organ damage in middle-aged men and women.

    LENUS (Irish Health Repository)

    Madden, J M

    2015-03-19

    Blood pressure variability (BPV) has been associated with cardiovascular events; however, the prognostic significance of short-term BPV remains uncertain. As uncertainty also remains as to which measure of variability most accurately describes short-term BPV, this study explores different indices and investigates their relationship with subclinical target organ damage (TOD). We used data from the Mitchelstown Study, a cross-sectional study of Irish adults aged 47-73 years (n=2047). A subsample (1207) underwent 24-h ambulatory BP monitoring (ABPM). As measures of short-term BPV, we estimated the s.d., weighted s.d. (wSD), coefficient of variation (CV) and average real variability (ARV). TOD was documented by microalbuminuria and electrocardiogram (ECG) left ventricular hypertrophy (LVH). There was no association found between any measure of BPV and LVH in both unadjusted and fully adjusted logistic regression models. Similar analysis found that ARV (24 h, day and night), s.d. (day and night) and wSD were all univariately associated with microalbuminuria and remained associated after adjustment for age, gender, smoking, body mass index (BMI), diabetes and antihypertensive treatment. However, when the models were further adjusted for the mean BP the association did not persist for all indices. Our findings illustrate choosing the appropriate summary measure, which accurately captures that short-term BPV is difficult. Despite discrepancies in values between the different measures, there was no association between any indexes of variability with TOD measures after adjustment for the mean BP.Journal of Human Hypertension advance online publication, 19 March 2015; doi:10.1038\\/jhh.2015.18.

  5. Immunogenicity and reactogenicity of a recombinant hepatitis B vaccine in subjects over age of forty years and response of a booster dose among nonresponders

    Institute of Scientific and Technical Information of China (English)

    Kunal Das; R. K. Gupta; V. Kumar, P.Kar

    2003-01-01

    AIM: The study was initiated to evaluate the reactogenicity and immunogenicity of a recombinant hepatitis B vaccine in age group >40 years and to study the response of a single booster dose in primary non-responders to the hepatitis B vaccination.METHODS: A total of 102 volunteers without markers of hepatitis B infection (negative for HBsAg, anti-HBc antibody,HBeAg and anti-HBs antibody) received 20 pg of recombinant HB vaccine intramuscularly at 0, 1, and 6 months. Anti HBs titers were evaluated by a quantitative Elisa kit at 90 and 210 days. A booster dose of 20 pg HB vaccine was given after 6 months of the 3rd vaccine dose to the 15 nonresponders and anti-HBs titers were measured after 1 month.RESULTS: Seroprotection (anti-HBs GMT3 10 IU/L) was achieved in 85.3 % (87/102) volunteers. The mean GMT titers of the vaccine responders was 136.1 IU/L. Of the seroprotected individuals, there were 32.4 % (33/102) hyporesponders (antiHBs titers <10-99 mlU/ml) and 52.9 % (54/102) were responders (anti-HBs titers >100 IU/L). All the non-responders (15/15) responded to a single dose of the booster dose of recombinant HB vaccine and their mean anti-HBs antibody titers were more than 100.5 mIU/ml after the booster dose.CONCLUSION: Recombinant hepatitis B vaccine offers good seroprotection in the age group >40 years and has a good safety profile. A single booster dose after 6 months in primary non-responders leads to good seroprotective anti-HBs antibody titers. However, larger population based studies are needed to evaluate the role of a booster dose in selected group of non-responders and whether such an approach will be cost effective.

  6. Fractionated gemtuzumab ozogamicin and standard dose cytarabine produced prolonged second remissions in patients over the age of 55 years with acute myeloid leukemia in late first relapse.

    Science.gov (United States)

    Pilorge, Sylvain; Rigaudeau, Sophie; Rabian, Florence; Sarkozy, Clémentine; Taksin, Anne L; Farhat, Hassan; Merabet, Fathia; Ghez, Stéphanie; Raggueneau, Victoria; Terré, Christine; Garcia, Isabelle; Renneville, Aline; Preudhomme, Claude; Castaigne, Sylvie; Rousselot, Philippe

    2014-04-01

    Gemtuzumab ozogamicin (fGO), a humanized anti-CD33 monoclonal antibody linked to calicheamicin in combination with intensive chemotherapy gives high response rates in adult acute myeloid leukemia (AML) patients in relapse. However, reduced intensity chemotherapy in combination with fractionated GO has not been tested in aged relapsing patients. Patients from our institution with CD33+ AML aged 55 years or more in first late relapse (≥ 6 months) were proposed participation in a GO compassionate use program. Induction therapy consisted in fractionated GO (fGO; 3 mg/m², days 1, 4, 7) with standard-dose cytarabine (200 mg/m² /day, 7 days). Patients were consolidated with two courses of GO and intermediate dose cytarabine. Twenty-four patients (median age 68 years) received fGO with cytarabine. Median follow-up was 42 months. The response rate was 75%, including complete remission (CR) in 16 patients and CR with incomplete platelet recovery (CRp) in two patients. Two-year overall survival (OS) was 51% (95% CI: 28-69) and 2 years relapse-free survival (RFS) was 51% (95%CI: 25-72). Duration of second CR (CR2) was longer than first CR (CR1) in 9 out of 18 patients. Minimal residual disease (MRD) was negative in evaluable patients in CR2, particularly in NPM1 mutated cases. Toxicity was in line with that of the same fractionated single agent GO schedule. Fractionated GO with low intensity chemotherapy produced high response rates and prolonged CR2 in aged AML patients in first late relapse. PMID:24375467

  7. Liquid structure and viscosity of In80Cu20 alloy

    Institute of Scientific and Technical Information of China (English)

    程素娟; 王忠华; 边秀房; 秦绪波; 司鹏超

    2004-01-01

    The structure and dynamic viscosity of In80Cu20 alloy melt in the temperature range from 600 ℃ to 1 000℃ were investigated by using a high-temperature X-ray diffractometer and a torsional oscillation viscometer. The experiments show that there exist medium range order (MRO) structures in In80Cu20 alloy melt in a low temperature range above liquidus. The MRO structures are weakened with increasing temperature and disappear when the temperature surpasses 800 ℃. The nearest interatomic distance r1 and the coordination number Ns of In80Cu20 alloy melt decrease as temperature increases from 650 ℃ to 1 000 ℃. Thermal contraction of atom clusters can be found in the heating process. The viscosity of In80Cu20 alloy melt drops as temperature increases and meets with the exponential relation. No sudden change in structure occurs in the measured temperature range. DSC curve of In80Cu20 alloy during cooling process was measured. It is found that there is no noticeable variation of heat during cooling from 1000 ℃ to 600 ℃ , which testifies further that there is no sudden change in structure of In80Cu20 alloy melt.

  8. Aged-Related Changes in Body Composition and Association between Body Composition with Bone Mass Density by Body Mass Index in Chinese Han Men over 50-year-old.

    Directory of Open Access Journals (Sweden)

    Ying Jiang

    Full Text Available Aging, body composition, and body mass index (BMI are important factors in bone mineral density (BMD. Although several studies have investigated the various parameters and factors that differentially influence BMD, the results have been inconsistent. Thus, the primary goal of the present study was to further characterize the relationships of aging, body composition parameters, and BMI with BMD in Chinese Han males older than 50 years.The present study was a retrospective analysis of the body composition, BMI, and BMD of 358 Chinese male outpatients between 50 and 89 years of age that were recruited from our hospital between 2009 and 2011. Qualified subjects were stratified according to age and BMI as follows: 50-59 (n = 35, 60-69 (n = 123, 70-79 (n = 93, and 80-89 (n = 107 years of age and low weight (BMI: < 20 kg/m2; n = 21, medium weight (20 ≤ BMI < 24 kg/m2; n = 118, overweight (24 ≤ BMI < 28 kg/m2; n = 178, and obese (BMI ≥ 28 kg/m2; n = 41. Dual-energy X-ray absorptiometry (DEXA was used to assess bone mineral content (BMC, lean mass (LM, fat mass (FM, fat-free mass (FFM, lumbar spine (L1-L4 BMD, femoral neck BMD, and total hip BMD. Additionally, the FM index (FMI; FM/height2, LM index (LMI; LM/height2, FFM index (FFMI; [BMC+LM]/height2, percentage of BMC (%BMC; BMC/[BMC+FM+LM] × 100%, percentage of FM (%FM; FM/[BMC+FM+LM] × 100%, and percentage of LM (%LM; LM/(BMC+FM+LM × 100% were calculated. Osteopenia or osteoporosis was identified using the criteria and T-score of the World Health Organization.Although there were no significant differences in BMI among the age groups, there was a significant decline in height and weight according to age (p < 0.0001 and p = 0.0002, respectively. The LMI and FFMI also declined with age (both p < 0.0001 whereas the FMI exhibited a significant increase that peaked in the 80-89-years group (p = 0.0145. Although the absolute values of BMC and LM declined with age (p = 0.0031 and p < 0

  9. Sandy desertification cycles in the southwestern Mu Us Desert in China over the past 80 years recorded based on nebkha sediments

    Science.gov (United States)

    Li, Jinchang; Zhao, Yanfang; Liu, Haixia; Su, Zhizhu

    2016-03-01

    Sandy desertification (SDN) cycles in the southwestern Mu Us Desert since the late 1920s were recorded based on the evolution of Nitraria tangutorum nebkhas. Particle size changes of the nebkha excavated during the study, together with AMS 14C and 137Cs dating controls, indicated that the SDN of the study area was reverse on the whole over the past 80 years, but multiple SDN cycles also occurred. SDN mainly occurred during the late 1920s to the early 1940s, late 1940s to early 1950s, late 1950s to early 1960s, mid- and late 1980s, and early 2000s. The formation of nebkhas in the study area was triggered by severe SDN caused by extreme drought events that occurred in the 1920s to the 1930s. Over the past 80 years, the general SDN trend in the southwestern Mu Us Desert was mainly controlled by the westerly circulation strength, and severe SDN resulted mainly from extreme drought events in a large spatial scale, whereas slight SDN cycles were mainly due to local climate fluctuations and human activities.

  10. The Gold Standard Program for Smoking Cessation is Effective for Participants Over 60 Years of Age

    DEFF Research Database (Denmark)

    Flamand, Mette Kehlet; Schroeder, Torben V; Tønnesen, Hanne

    2015-01-01

    BACKGROUND: Tobacco smoking is more prevalent among the elderly than among the young, and the elderly also have the most frequent contact with the health care system. The aim of this study was to evaluate the effectiveness of the Gold Standard Program, which is an intensive six-week smoking...... cessation program, on continuous self-reported abstinence rates after six months, on participants over the age of 60 years in a real life setting. METHODS: This was a retrospective cohort study from the national Danish smoking cessation database. RESULTS: The database registered 7369 participants over...... recommendation for smoking cessation (OR 1.12), being compliant with program (OR 1.35) and being abstinent at end of course (OR 13.3). CONCLUSIONS: Participants over the age of 60 years had significantly higher continuous abstinence rates after six months than the participants less than 60 years. It is never too...

  11. Quality prevails over identity in the sexually selected vocalisations of an ageing mammal

    Directory of Open Access Journals (Sweden)

    Vannoni Elisabetta

    2010-04-01

    Full Text Available Abstract Background Male sexually selected vocalisations generally contain both individuality and quality cues that are crucial in intra- as well as inter-sexual communication. As individuality is a fixed feature whereas male phenotypic quality changes with age, individuality and quality cues may be subjected to different selection pressures over time. Individuality (for example, morphology of the vocal apparatus and quality (for example, body size and dominance status can both affect the vocal production mechanism, inducing the same components of vocalisations to convey both kinds of information. In this case, do quality-related changes to the acoustic structure of calls induce a modification of vocal cues to identity from year to year? We investigated this question in fallow deer (Dama dama, in which some acoustic parameters of vocalisations (groans code for both individuality and quality. Results We carried out a longitudinal analysis of groan individuality, examining the effects of age and dominance rank on the acoustic structure of groans of the same males recorded during consecutive years. We found both age- and rank-related changes to groans; the minimum values of the highest formant frequencies and the fundamental frequency increased with the age of males and they decreased when males became more dominant. Both age- and rank-related acoustic parameters contributed to individuality. Male quality changed with age, inducing a change in quality-related parameters and thus, a modification of vocal cues to male individuality between years. Conclusions The encoding of individuality and quality information in the same components of vocalisations induces a tradeoff between these two kinds of signals over time. Fallow deer vocalisations are honest signals of quality that are not fixed over time but are modified dynamically according to male quality. As they are more reliable cues to quality than to individuality, they may not be used by

  12. The evolution of microstructure in Cu-8.0Ni-1.8Si-0.15Mg alloy during aging

    International Nuclear Information System (INIS)

    The microstructure of precipitates in Cu-8.0Ni-1.8Si-0.15Mg (wt.%) alloy with super-high strength and high electrical conductivity was investigated by transmission electron microscope and selected-area electronic diffraction. The sequence of phase transformation in the alloy with aging time is that: spinodal decomposition + ordering(β-Ni3Si) → ordering(β-Ni3Si) + δ-Ni2Si → δ-Ni2Si + β-Ni3Si. And the relationship between the matrix and precipitates is that: (110)m//(110)β//(211-bar)δ, [112-bar]m//[11-bar 2]β//[324]δ. Spinodal decomposition, ordering (β-Ni3Si) and precipitates (β-Ni3Si + δ-Ni2Si) are attributed to the strengthening during aging, whose multiple interactions results in the variation of micro-hardness. After solution treatment at 970 deg. C for 6 h, cool rolled by 50%, and aged at 450 deg. C for 180 min, the Cu-8.0Ni-1.8Si-0.15Mg alloy has an average tensile strength of 1005 MPa, 0.2% proof strength of 768 MPa, elongation of 5.6% and an average electrical conductivity of 31.5.0% IACS. The morphology of the fracture surface of the alloy contains shallow dimple and quasi-cleavage pattern.

  13. Investigation of sleep disturbance in chronic low back pain: an age- and gender-matched case-control study over a 7-night period.

    LENUS (Irish Health Repository)

    van de Water, Alexander T M

    2011-12-01

    Sleep disturbance is frequently reported by people with chronic low back pain (>12 weeks; CLBP), but few studies have comprehensively investigated sleep in this population. This study investigated differences in subjectively and objectively measured sleep patterns of people with CLBP, and compared this to age- and gender matched controls. Thirty-two consenting participants (n = 16 with CLBP, n = 16 matched controls), aged 24-65 years (43.8% male) underwent an interview regarding sleep influencing variables, completed the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Pittsburgh Sleep Diary, SF36-v2, Hospital Anxiety and Depression Scale, Oswestry Disability Index, Numerical Pain Rating Scales, and underwent seven consecutive nights of actigraphic measurement in the home environment. Compared to controls, people with CLBP had, on self-report measures, significantly poorer sleep quality [Pittsburgh Sleep Quality Index (range 0-21) mean (SD) 10.9 (4.2)], clinical insomnia [Insomnia Severity Index mean (range 0-28) 13.7 (7.6)], lower sleep efficiency, longer sleep onset latency, more time awake after sleep onset, and more awakenings during sleep (p < 0.05). However, no significant differences between groups were found on objective actigraphy (p > 0.05). The findings provide some evidence to support self-reported sleep assessment as an outcome measure in CLBP research, while further research is needed to determine the validity of objective sleep measurement in this population.

  14. Sea-level records at ~80 ka from tectonically stable platforms: Florida and Bermuda

    Science.gov (United States)

    Ludwig, K. R.; Muhs, D.R.; Simmons, K.R.; Halley, R.B.; Shinn, E.A.

    1996-01-01

    Studies from technically active coasts on New Guinea and Barbados have suggested that sea level at ???80 ka was significantly lower than present, whereas data from the Atlantic and Pacific coasts of North America indicate an ???80 ka sea level close to that of the present. We determined ages of corals from a shallow submerged reef off the Florida Keys and an emergent marine deposit on Bermuda. Both localities are on tectonically stable platforms distant from plate boundaries. Uranium-series ages show that corals at both localities grew during the ???80 ka sea-level highstand, and geologic data show that sea level at that time was no lower than 7-9 m below present (Florida) and may have been 1-2 m above present (Bermuda). The ice-volume discrepancy of the 80 ka sea-level estimates is greater than the volume of the Greenland or West Antarctic ice sheets. Comparison of our ages with high-latitude insolation values indicates that the sea-level stand near the present at ???80 ka could have been orbitally forced.

  15. Association between Socioeconomic Status and Cancer Screening in Koreans over 40 Years in Age Based on the 2010–2012 Korean National Health and Nutrition Examination Survey

    Science.gov (United States)

    Kim, Jin-Young

    2016-01-01

    Background We investigated the association between socioeconomic status (SES) and cancer screening in a Korean population aged 40 years or older. Methods This cross-sectional study included 12,303 participants (5,284 men and 7,019 women) who participated in the 2010–2012 Korean National Health and Nutrition Examination Survey. Self-reported questionnaires were used to assess participant's SES (household income, occupational, and educational status) and cancer screening behavior. Results Compared to the lowest household income group, the odds ratios (ORs) (95% confidence intervals [CIs]) for overall cancer screening of the highest income group were 2.113 (1.606–2.781) in men and 1.476 (1.157–1.883) in women; those for private cancer screening of the highest income group were 2.446 (1.800–3.324) in men and 2.630 (2.050–3.373) in women, while those for National Cancer Screening Programs (NCSP) in the highest income group were 1.076 (0.805–1.439) in men and 0.492 (0.388–0.623) in women. Compared to manual workers, ORs (95% CIs) for private cancer screening of office workers were 1.300 (1.018–1.660) in men and 0.822 (0.616–1.098) in women. In comparison to the least educated men, OR (95% CI) for private cancer screening of the most educated men was statistically significant (1.530 [1.117–2.095]). Conclusion Higher economic status was associated with higher rates of overall and private cancer screening in both sexes and a lower rate of NCSP in women. Male office workers and more educated individuals underwent private cancer screening at a higher rate than manual workers and less educated individuals, respectively.

  16. A retrospective analysis of the clinical characteristics in newly diagnosed diffuse large B-cell lymphoma in elderly patients aged 70 years and over%老年初诊弥漫性大B细胞淋巴瘤患者临床特点回顾性分析

    Institute of Scientific and Technical Information of China (English)

    李江涛; 刘辉; 范芸; 冯茹; 张野坪; 程玮; 田园; 常乃柏

    2016-01-01

    目的 探讨老年弥漫性大B细胞淋巴瘤(DLBCL)患者的预后危险因素及可行的治疗方案. 方法 收集我院近10年收治≥70岁老年初诊DLBCL患者的临床资料及生存资料,回顾性分析影响患者治疗有效率、总生存期(OS)和无进展生存期(PFS)的因素. 结果 本组患者49例,年龄70~92岁,中位年龄76岁;其中≥80岁18例,<80岁31例.治疗以美罗华(R)联合环磷酰胺(C)、阿霉素(H)、长春新碱(O)、强的松(P)方案(R-CHOP)为基础,体能状态较差或≥80岁患者,美罗华剂量不变,CHOP以标准剂量的50%~75%为初始剂量.49例患者中,完全缓解23例(46.9%),部分缓解9例(18.4%),总有效率65.3%.至随访截止日期共死亡30例,中位总生存期25个月.Ann Arbor分期Ⅰ~Ⅱ期、LDH(乳酸脱氢酶)<245 U/L、年龄<80岁、IPI(国际预后指数)≤2、6疗程R CHOP与总生存期延长有关;多因素分析结果显示,LDH<245 U/L和6疗程R CHOP为独立预后因素.完成6程R-CHOP方案治疗,≥80岁组7例(38.9%),<80岁组17例(54.8%);两组患者总生存期(32个月比34个月)和无进展生存期(32个月比32个月)比较,差异无统计学意义. 结论 对于不能耐受标准剂量治疗的高龄患者,通过减低剂量并完成6程R-CHOP治疗,能够改善患者预后;6程R-CHOP是影响老年DLBCL患者预后的独立危险因素.%Objective To explore the prognostic factors and treatment regimens of diffuse large B-cell lymphoma (DLBCL) in elderly patients.Methods The data of characteristics,treatment regimens and outcomes were collected in elderly patients aged 70 years and over,with newly diagnosed DLBCL from our hospital in the last decade.Then the factors influencing therapeutic response,overall survival and progression-free survival were analyzed.Results A total of 49 patients aged 70 to 92 years (median 76 years) were enrolled in this study.Among them,18 patients were aged 80 years and older;the other 31 patients were

  17. CERN celebrates science over and over again!

    CERN Document Server

    Anaïs Schaeffer

    2013-01-01

    CERN is getting ready to open its doors for two days of science and entertainment, but the celebrations don’t stop here. From 9 October 2013, France’s Fête de la Science will take up the reins. With more than 1,000 events all over France on the theme “From the infinitely large to the infinitely small", one of them is bound to be taking place near you.   Part of the programme from the Fête de la science in 2013 in the Rhône-Alpes region. Download the full programme here. The nearest one to CERN will be in Divonne-les-Bains. Put Wednesday, 9 October in your diary, because CERN will be taking part! From 10.30 a.m., join the members of Divonnelectro, an association set up by a group of CERN retirees, for a visit to France's oldest hydroelectric factory. At 2.30 p.m., head to the Esplanade du Lac in Divonne-les-Bains, where members of the Université pour tous du Pays de Gex will be offering ...

  18. Development and validation of a risk score predicting substantial weight gain over 5 years in middle-aged European men and women.

    Directory of Open Access Journals (Sweden)

    Annika Steffen

    Full Text Available BACKGROUND: Identifying individuals at high risk of excess weight gain may help targeting prevention efforts at those at risk of various metabolic diseases associated with weight gain. Our aim was to develop a risk score to identify these individuals and validate it in an external population. METHODS: We used lifestyle and nutritional data from 53°758 individuals followed for a median of 5.4 years from six centers of the European Prospective Investigation into Cancer and Nutrition (EPIC to develop a risk score to predict substantial weight gain (SWG for the next 5 years (derivation sample. Assuming linear weight gain, SWG was defined as gaining ≥ 10% of baseline weight during follow-up. Proportional hazards models were used to identify significant predictors of SWG separately by EPIC center. Regression coefficients of predictors were pooled using random-effects meta-analysis. Pooled coefficients were used to assign weights to each predictor. The risk score was calculated as a linear combination of the predictors. External validity of the score was evaluated in nine other centers of the EPIC study (validation sample. RESULTS: Our final model included age, sex, baseline weight, level of education, baseline smoking, sports activity, alcohol use, and intake of six food groups. The model's discriminatory ability measured by the area under a receiver operating characteristic curve was 0.64 (95% CI = 0.63-0.65 in the derivation sample and 0.57 (95% CI = 0.56-0.58 in the validation sample, with variation between centers. Positive and negative predictive values for the optimal cut-off value of ≥ 200 points were 9% and 96%, respectively. CONCLUSION: The present risk score confidently excluded a large proportion of individuals from being at any appreciable risk to develop SWG within the next 5 years. Future studies, however, may attempt to further refine the positive prediction of the score.

  19. Is the Golden Age of the Private Research University Over?

    Science.gov (United States)

    Ehrenberg, Ronald G.

    2013-01-01

    After receiving his PhD in 1970, the author has spent almost 30 years conducting research on the economics of higher education, chairing faculty budget committees at Cornell, serving as a Cornell vice president and then as a trustee of both Cornell and SUNY, and being associated with innumerable national commissions and higher education…

  20. Age- and gender-specific estimates of cumulative CT dose over 5 years using real radiation dose tracking data in children

    International Nuclear Information System (INIS)

    It is necessary to develop a mechanism to estimate and analyze cumulative radiation risks from multiple CT exams in various clinical scenarios in children. To identify major contributors to high cumulative CT dose estimates using actual dose-length product values collected for 5 years in children. Between August 2006 and July 2011 we reviewed 26,937 CT exams in 13,803 children. Among them, we included 931 children (median age 3.5 years, age range 0 days-15 years; M:F = 533:398) who had 5,339 CT exams. Each child underwent at least three CT scans and had accessible radiation dose reports. Dose-length product values were automatically extracted from DICOM files and we used recently updated conversion factors for age, gender, anatomical region and tube voltage to estimate CT radiation dose. We tracked the calculated CT dose estimates to obtain a 5-year cumulative value for each child. The study population was divided into three groups according to the cumulative CT dose estimates: high, ≥30 mSv; moderate, 10-30 mSv; and low, <10 mSv. We reviewed clinical data and CT protocols to identify major contributors to high and moderate cumulative CT dose estimates. Median cumulative CT dose estimate was 5.4 mSv (range 0.5-71.1 mSv), and median number of CT scans was 4 (range 3-36). High cumulative CT dose estimates were most common in children with malignant tumors (57.9%, 11/19). High frequency of CT scans was attributed to high cumulative CT dose estimates in children with ventriculoperitoneal shunt (35 in 1 child) and malignant tumors (range 18-49). Moreover, high-dose CT protocols, such as multiphase abdomen CT (median 4.7 mSv) contributed to high cumulative CT dose estimates even in children with a low number of CT scans. Disease group, number of CT scans, and high-dose CT protocols are major contributors to higher cumulative CT dose estimates in children. (orig.)

  1. Age- and gender-specific estimates of cumulative CT dose over 5 years using real radiation dose tracking data in children

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Eunsol; Goo, Hyun Woo; Lee, Jae-Yeong [University of Ulsan College of Medicine, Asan Medical Center, Department of Radiology and Research Institute of Radiology, Seoul (Korea, Republic of)

    2015-08-15

    It is necessary to develop a mechanism to estimate and analyze cumulative radiation risks from multiple CT exams in various clinical scenarios in children. To identify major contributors to high cumulative CT dose estimates using actual dose-length product values collected for 5 years in children. Between August 2006 and July 2011 we reviewed 26,937 CT exams in 13,803 children. Among them, we included 931 children (median age 3.5 years, age range 0 days-15 years; M:F = 533:398) who had 5,339 CT exams. Each child underwent at least three CT scans and had accessible radiation dose reports. Dose-length product values were automatically extracted from DICOM files and we used recently updated conversion factors for age, gender, anatomical region and tube voltage to estimate CT radiation dose. We tracked the calculated CT dose estimates to obtain a 5-year cumulative value for each child. The study population was divided into three groups according to the cumulative CT dose estimates: high, ≥30 mSv; moderate, 10-30 mSv; and low, <10 mSv. We reviewed clinical data and CT protocols to identify major contributors to high and moderate cumulative CT dose estimates. Median cumulative CT dose estimate was 5.4 mSv (range 0.5-71.1 mSv), and median number of CT scans was 4 (range 3-36). High cumulative CT dose estimates were most common in children with malignant tumors (57.9%, 11/19). High frequency of CT scans was attributed to high cumulative CT dose estimates in children with ventriculoperitoneal shunt (35 in 1 child) and malignant tumors (range 18-49). Moreover, high-dose CT protocols, such as multiphase abdomen CT (median 4.7 mSv) contributed to high cumulative CT dose estimates even in children with a low number of CT scans. Disease group, number of CT scans, and high-dose CT protocols are major contributors to higher cumulative CT dose estimates in children. (orig.)

  2. The Golden Age of Reference Service: Is It Really Over?

    Science.gov (United States)

    Rice, James

    1986-01-01

    Argues that reference services will not only survive changes brought about by new technologies, but will be improved and enhanced as a result. Examples given include online public access catalogs, automated record-keeping operations, CD-ROM as an information storage medium, the continuing need for intermediaries in online searching, and copyright…

  3. Methotrexate in Psoriatics over 50 years of age

    OpenAIRE

    Kaur I; Handa S; Kumar Bhushan; Dhar S

    1995-01-01

    Retrospective analysis was made of data on the use of methotrexate in elderly psoriatics. Pre-methotrexate assessment of patients induced liver function tests and a liver biopsy in 11 out of 14 patients. Post-methotrexate biopsies were done in 3 patients with total cumulative dose of methotrexate exceeding 1.5 gms. No significant worsening in the liver histology grade was noticed in the elderly patients. No significant side effect of methotrexate was noticed.

  4. Exercise and age

    Science.gov (United States)

    Age and exercise ... It is never too late to start exercising. Exercise has benefits at any age. Don't worry ... as you age. The right kind of regular exercise can also reduce your risk of heart disease, ...

  5. Regional aging and longevity characteristics in China.

    Science.gov (United States)

    Wang, Li; Li, Yonghua; Li, Hairong; Holdaway, Jennifer; Hao, Zhe; Wang, Wuyi; Krafft, Thomas

    2016-01-01

    The factors that influence the length of human life are complex and longevity remains a controversial topic, particularly in China. This paper demonstrates the spatial patterns and changes of the elderly group (65 years old and over), the oldest old (80 years old and over) and the centenarians in China in the last decade, analyzes the influence of economic development on aging, and in the end, using a case study, explores the characteristics of the centenarians' behavior. The results indicate that high elderly and the oldest old proportions are more common in regions with higher socio-economic development and that have a favorable climate. Centenarian distribution pattern is less influenced by economic but only for few regions. Lifestyle factors, such as sufficient sleep, positive mental state and a light diet are also largely found among the centenarian group. PMID:27544461

  6. C80H80几何结构和电子性质的密度泛函研究%Density functional study on the geometric and electronic properties of C80H80

    Institute of Scientific and Technical Information of China (English)

    曹青松; 袁勇波; 肖传云; 陆瑞锋; 阚二军; 邓开明

    2012-01-01

    The generalized gradient approximation based on the density functional theory is used to analyze the geometric and the electronic properties of C80H80. The geometric structure research indicates that between the two possible stable isomers, the isomer with 20 hydrogens connecting 12 pentagons and the 60 others outside is more stable structure. The analyses of the energy level, the orbital wavefunction, and the density of states of H20 @C80H60, show that the atomic orbits of the H and C atoms have strong hybridization on the occupied molecular orbits. The low unoccupied molecular orbital of H20@C80H60 is occupied mainly by the H atoms inside the carbon cage, while the high occupied molecular orbital of H20@C80H60 are occupied partly by the H atoms outside the cage. Therefore, the H atoms inside and outside the cage will play different roles in the chemical reaction involving H20@C80H60. TheH20@C80H60 shows the character of the closed-shell structures with no magnetic moment.%采用密度泛函理论方法中的广义梯度近似,对C80H80几何结构和电子性质进行了研究.几何结构研究表明:在C80H80可能稳定存在的两种同分异构体中,连接12个五边形的20个c原子内部氢化,其余60个C原子外部氢化所形成的结构即H20@C80H60最稳定,其仍然保持厶对称性.通过对H20@C80H60的能级、前线轨道和态密度分析可知:在H20@C80H60中,H原子的原子轨道与C原子的原子轨道之间在占据态轨道上有较强的杂化,H原子对H20@C80H60的占据态轨道的贡献比较大.其最高占据轨道主要由外部H原子和碳笼来贡献,而最低未占据轨道主要由内部H原子贡献,表明内外H原子在H20@C80H60的化学反应中承担不同的角色.H20@C80H60为闭壳层结构,所有电子都是配对的,表现为非磁性.

  7. Clinical features of the elderly patients over 80 years with cute cerebral infarction%老老年急性脑梗死患者的临床特征分析

    Institute of Scientific and Technical Information of China (English)

    凌莉; 李小强; 张素平; 尹义臣; 王慕真; 何锐; 邓婉青

    2015-01-01

    Objective To investigate the risk factors,severity and infarct site features and clinical characteristics of the elderly patients over 80 years with cute cerebral infarction.Methods One hundred and sixty-two patients with acute cerebral infarction in Red Cross Hospital of Guangzhou,The Forth Affiliated Hospital of Medical College of Jinan University from January 2012 to May 2015 were enrolled and randomly divided into the elderly patients (≥ 80 years old) and the middle aged patients (< 60 years old).The risk factors,national institutes of health stroke scale (NIHSS) scores and Oxfordshire community stroke project (OCSP) criteria were compared between the two groups.Results Coronary artery disease,atrial fibrillation and NIHSS in the elderly patients (25% (22/88),13.6% (12/88),7.74 ± 4.986) were significantly higher than those of the middle aged group (12.2% (9/47),4.1% (3/74),5.04± 4.305),and the differences were significant (x2 =4.281,4.393,t =-3.649;P< 0.05 or P< 0.001).The logistic regression analysis finally showed that smoking,hyperlipemia,NIHSS scores and gender(male) were the independent risk factors(OR=3.851,3.609,1.100 and 2.670;P<0.05).There were more LACI patients in the elderly group than he middle aged group ((40.9%,36/88) vs.(60.8%,45/74),x2 =6.369,P < 0.05).Conclusion Compare to the middle aged patients,occurrence of the elderly patients with acute cerebral infarction is more severe,and the clinical features and risk factors have its particularity.Secondary prevention strategy should be emphasized on the control of different risk factors based on the patients' age.%目的 探讨老老年(≥80岁)急性脑梗死的危险因素、严重程度和梗死部位的特征.方法 选取2012年1月至2015年3月在我院住院的急性脑梗死患者162例,根据年龄分为≥80岁老年组88例和中青年(<60岁)组74例.对其危险因素、入院时的美国国立卫生研究院脑卒中量表(NIHSS

  8. 7 CFR 27.80 - Fees; classification, Micronaire, and supervision.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Fees; classification, Micronaire, and supervision. 27... Classification and Micronaire § 27.80 Fees; classification, Micronaire, and supervision. For services rendered by... classification and Micronaire determination results certified on cotton class certificates.) (e) Supervision,...

  9. Cancer in Women over 50 Years of Age: A Focus on Smoking

    International Nuclear Information System (INIS)

    The increase in life expectancy worldwide has resulted in a greater prevalence of chronic non-communicable diseases. This study aims to evaluate the prevalence and factors associated with the occurrence of cancer among Brazilian women over the age of 50. A cross-sectional study with 622 women over the age of 50 was performed using a population survey. The outcome variable was the occurrence of a malignant tumor in any location. The independent variables were sociodemographic characteristics, self-perception of health, health-related habits and morbidities. Statistical analysis was carried out using the chi-square test and Poisson regression. The mean age of the women was 64.1 years. The prevalence of cancer was 6.8%. The main sites of occurrence of malignant tumors were the breast (31.9%), colorectal (12.7%) and skin (12.7%). In the final statistical model, the only factor associated with cancer was smoking > 15 cigarettes/day either currently or in the past: PR 2.03 (95% CI 1.06–3.89). The results have improved understanding of the prevalence and factors associated with cancer in Brazilian women aged 50 years or more. They should be encouraged to maintain a healthy lifestyle and pay particular attention to modifiable risk factors such as smoking

  10. Cancer in Women over 50 Years of Age: A Focus on Smoking

    Energy Technology Data Exchange (ETDEWEB)

    Baccaro, Luiz Francisco, E-mail: luiz.baccaro@gmail.com [Department of Gynecology, State University of Campinas, Rua Alexander Fleming, 101, Cidade Universitária Zeferino Vaz, Campinas, São Paulo 13.083-881 (Brazil); Conde, Délio Marques [Breast Clinic, Hospital for Maternal and Child Healthcare, Goiânia, Goiás 74.125-120 (Brazil); Costa-Paiva, Lúcia; Machado, Vanessa de Souza Santos; Pinto-Neto, Aarão Mendes [Department of Gynecology, State University of Campinas, Campinas, São Paulo 13.083-881 (Brazil)

    2015-03-17

    The increase in life expectancy worldwide has resulted in a greater prevalence of chronic non-communicable diseases. This study aims to evaluate the prevalence and factors associated with the occurrence of cancer among Brazilian women over the age of 50. A cross-sectional study with 622 women over the age of 50 was performed using a population survey. The outcome variable was the occurrence of a malignant tumor in any location. The independent variables were sociodemographic characteristics, self-perception of health, health-related habits and morbidities. Statistical analysis was carried out using the chi-square test and Poisson regression. The mean age of the women was 64.1 years. The prevalence of cancer was 6.8%. The main sites of occurrence of malignant tumors were the breast (31.9%), colorectal (12.7%) and skin (12.7%). In the final statistical model, the only factor associated with cancer was smoking > 15 cigarettes/day either currently or in the past: PR 2.03 (95% CI 1.06–3.89). The results have improved understanding of the prevalence and factors associated with cancer in Brazilian women aged 50 years or more. They should be encouraged to maintain a healthy lifestyle and pay particular attention to modifiable risk factors such as smoking.

  11. Cancer in Women over 50 Years of Age: A Focus on Smoking

    Directory of Open Access Journals (Sweden)

    Luiz Francisco Baccaro

    2015-03-01

    Full Text Available The increase in life expectancy worldwide has resulted in a greater prevalence of chronic non-communicable diseases. This study aims to evaluate the prevalence and factors associated with the occurrence of cancer among Brazilian women over the age of 50. A cross-sectional study with 622 women over the age of 50 was performed using a population survey. The outcome variable was the occurrence of a malignant tumor in any location. The independent variables were sociodemographic characteristics, self-perception of health, health-related habits and morbidities. Statistical analysis was carried out using the chi-square test and Poisson regression. The mean age of the women was 64.1 years. The prevalence of cancer was 6.8%. The main sites of occurrence of malignant tumors were the breast (31.9%, colorectal (12.7% and skin (12.7%. In the final statistical model, the only factor associated with cancer was smoking > 15 cigarettes/day either currently or in the past: PR 2.03 (95% CI 1.06–3.89. The results have improved understanding of the prevalence and factors associated with cancer in Brazilian women aged 50 years or more. They should be encouraged to maintain a healthy lifestyle and pay particular attention to modifiable risk factors such as smoking.

  12. Cancer in Women over 50 Years of Age: A Focus on Smoking.

    Science.gov (United States)

    Baccaro, Luiz Francisco; Conde, Délio Marques; Costa-Paiva, Lúcia; de Souza Santos Machado, Vanessa; Pinto-Neto, Aarão Mendes

    2015-01-01

    The increase in life expectancy worldwide has resulted in a greater prevalence of chronic non-communicable diseases. This study aims to evaluate the prevalence and factors associated with the occurrence of cancer among Brazilian women over the age of 50. A cross-sectional study with 622 women over the age of 50 was performed using a population survey. The outcome variable was the occurrence of a malignant tumor in any location. The independent variables were sociodemographic characteristics, self-perception of health, health-related habits and morbidities. Statistical analysis was carried out using the chi-square test and Poisson regression. The mean age of the women was 64.1 years. The prevalence of cancer was 6.8%. The main sites of occurrence of malignant tumors were the breast (31.9%), colorectal (12.7%) and skin (12.7%). In the final statistical model, the only factor associated with cancer was smoking > 15 cigarettes/day either currently or in the past: PR 2.03 (95% CI 1.06-3.89). The results have improved understanding of the prevalence and factors associated with cancer in Brazilian women aged 50 years or more. They should be encouraged to maintain a healthy lifestyle and pay particular attention to modifiable risk factors such as smoking.

  13. Outlining the influence of non-conventional yeasts in wine ageing over lees.

    Science.gov (United States)

    Belda, Ignacio; Navascués, Eva; Marquina, Domingo; Santos, Antonio; Calderón, Fernando; Benito, Santiago

    2016-07-01

    During the last decade, the use of innovative yeast cultures of both Saccharomyces cerevisiae and non-Saccharomyces yeasts as alternative tools to manage the winemaking process have turned the oenology industry. Although the contribution of different yeast species to wine quality during fermentation is increasingly understood, information about their role in wine ageing over lees is really scarce. This work aims to analyse the incidence of three non-Saccharomyces yeast species of oenological interest (Torulaspora delbrueckii, Lachancea thermotolerans and Metschnikowia pulcherrima) and of a commercial mannoprotein-overproducer S. cerevisiae strain compared with a conventional industrial yeast strain during wine ageing over lees. To evaluate their incidence in mouthfeel properties of wine after 4 months of ageing, the mannoprotein content of wines was evaluated, together with other wine analytic parameters, such as colour and aroma, biogenic amines and amino acids profile. Some differences among the studied parameters were observed during the study, especially regarding the mannoprotein concentration of wines. Our results suggest that the use of T. delbrueckii lees in wine ageing is a useful tool for the improvement of overall wine quality by notably increasing mannoproteins, reaching values higher than obtained using a S. cerevisiae overproducer strain. Copyright © 2016 John Wiley & Sons, Ltd. PMID:27017923

  14. Worldwide cutaneous malignant melanoma incidences analyzed by sex, age, and skin type over time (1955–2007): Is HPV infection of androgenic hair follicular melanocytes a risk factor for developing melanoma exclusively in people of European-ancestry?

    Science.gov (United States)

    Merrill, Stephen J.; Subramanian, Madhan; Godar, Dianne E.

    2016-01-01

    ABSTRACT The cutaneous malignant melanoma (CMM) incidence has been increasing in an exponential manner in certain populations around the world for over 7 decades. To help illuminate the etiology, we performed worldwide temporal (1955–2007) CMM incidence analysis by sex, age (0–14, 15–29, 30–49, 50–69, 70–85+), and skin type on 6 continents using data from the International Agency for Research on Cancer. We observe an exponential increase in the CMM incidence over time and an increase of about 2 orders of magnitude between age groups 0–14 and 15–29 exclusively in European-ancestry populations around the world independent of skin type (I–III or III–IV). Other populations like the Chinese (III-IV) had much lower CMM incidences that either remained stable or temporally decreased but did not display a dramatic increase between the youngest age groups. The dramatic increase in the incidence between the youngest age groups found only in European-ancestry populations suggests one of the most important risk factors for CMM may be developing androgenic hair, the occurrence of which appears to correlate with the distribution of CMM over male and female body sites. Besides that potential new risk factor, the increasing CMM incidence with increasing age, known not to be from cumulative UV doses, may be associated with age-related changes to skin, i.e., thinning epidermis causing lower vitamin D3 levels, and hair, i.e., whitening from higher reactive oxygen species. The temporal exponential increasing CMM incidence in European-ancestry populations may be due to Human Papilloma Virus infection of follicular hair melanocytes, found in CMM biopsies. PMID:27588159

  15. Worldwide cutaneous malignant melanoma incidences analyzed by sex, age, and skin type over time (1955-2007): Is HPV infection of androgenic hair follicular melanocytes a risk factor for developing melanoma exclusively in people of European-ancestry?

    Science.gov (United States)

    Merrill, Stephen J; Subramanian, Madhan; Godar, Dianne E

    2016-01-01

    The cutaneous malignant melanoma (CMM) incidence has been increasing in an exponential manner in certain populations around the world for over 7 decades. To help illuminate the etiology, we performed worldwide temporal (1955-2007) CMM incidence analysis by sex, age (0-14, 15-29, 30-49, 50-69, 70-85+), and skin type on 6 continents using data from the International Agency for Research on Cancer. We observe an exponential increase in the CMM incidence over time and an increase of about 2 orders of magnitude between age groups 0-14 and 15-29 exclusively in European-ancestry populations around the world independent of skin type (I-III or III-IV). Other populations like the Chinese (III-IV) had much lower CMM incidences that either remained stable or temporally decreased but did not display a dramatic increase between the youngest age groups. The dramatic increase in the incidence between the youngest age groups found only in European-ancestry populations suggests one of the most important risk factors for CMM may be developing androgenic hair, the occurrence of which appears to correlate with the distribution of CMM over male and female body sites. Besides that potential new risk factor, the increasing CMM incidence with increasing age, known not to be from cumulative UV doses, may be associated with age-related changes to skin, i.e., thinning epidermis causing lower vitamin D3 levels, and hair, i.e., whitening from higher reactive oxygen species. The temporal exponential increasing CMM incidence in European-ancestry populations may be due to Human Papilloma Virus infection of follicular hair melanocytes, found in CMM biopsies. PMID:27588159

  16. Population Aging and Inventive Activity

    OpenAIRE

    Irmen, Andreas; Litina, Anastasia

    2016-01-01

    This research empirically establishes and theoretically motivates the hypothesis that population aging has a hump-shaped effect on inventive activity. We estimate this hump-shaped relationship in a panel of 33 OECD countries over the period 1960-2012. The increasing part of the hump captures the awareness that population aging requires inventive activity to guarantee current and future standards of living. The decreasing part reflects the tendency of aging societies to lose dynamism and the w...

  17. Aging and the intestine

    Institute of Scientific and Technical Information of China (English)

    Laurie Drozdowski; Alan BR Thomson

    2006-01-01

    Over the lifetime of the animal, there are many changes in the function of the body's organ systems. In the gastrointestinal tract there is a general modest decline in the function of the esophagus, stomach, colon,pancreas and liver. In the small intestine, there may be subtle alterations in the intestinal morphology, as well as a decline in the uptake of fatty acids and sugars.The malabsorption may be partially reversed by aging glucagon-like peptide 2 (GLP2) or dexamethasone.Modifications in the type of lipids in the diet will influence the intestinal absorption of nutrients: for example, in mature rats a diet enriched with saturated as compared with polysaturated fatty acids will enhance lipid and sugar uptake, whereas in older animals the opposite effect is observed. Thus, the results of studies of the intestinal adaptation performed in mature rats does not necessarily apply in older animals. The age-associated malabsorption of nutrients that occurs with aging may be one of the several factors which contribute to the malnutrition that occurs with aging.

  18. 17 CFR 200.80 - Commission records and information.

    Science.gov (United States)

    2010-04-01

    ... of the Commission appears below as appendix A to this subpart (17 CFR 200.80a). Most of the records..., information received by or given to the Commission in confidence, or any contents of personnel and medical and... established by an executive order to be kept secret in the interest of national defense or foreign policy,...

  19. Bladder preservation by internal iliac arterial infusion chemotherapy and irradiation in T3 bladder carcinoma patients over the age of 70 years

    Energy Technology Data Exchange (ETDEWEB)

    Hoshi, Senji; Shintaku, Ichiro; Suzuki, Ken-ichi; Takahashi, Toshiko; Kaihou, Yasuhiro; Ishidoya, Shigeto; Namima, Takashige; Ohyama, Chikara; Orikasa, Seiichi [Tohoku Univ., Sendai (Japan). School of Medicine

    2000-12-01

    Treatment by internal iliac arterial infusion chemotherapy (IA) combined with pelvic irradiation has proved to be effective for locally invasive bladder. Eight male patients, median age of 78 years (range 73-81) were enrolled. Pretreatment CT and whole layer core biopsy revealed T3a or T3b. Pelvic CT or fine needle aspiration biopsy following bipedal lymphography revealed N0 in 4 cases, N2 in 2 and N3 in 2, respectively. Three to 7 cycles of cisplatin (CDDP) 30-50 mg/m{sup 2}, methotrexate 20 mg/m{sup 2} and tetrahydropymnyl-adriamycin 20 mg/m{sup 2} every 3 week was administered combined with 40-50 Gy of whole pelvis irradiation. In 4 renal function impaired patients, 100 mg/m{sup 2} of carboplatin was administered instead of CDDP. All patients obtained complete response and the bladders were preserved. Observation periods were from 9 to 75 months (median 37 months). One N2 patient died with metastatic disease and two died without carcinoma. Two patients developed invasive bladder cancer on the side opposite to the primary tumors. Both were successfully treated by IA and irradiation. Bladders of all except one patient functioned for a long period. Side effects of IA and irradiation were not significant. IA combined with pelvic irradiation is effective and safe for elderly patients with bladder carcinoma. (author)

  20. Interactions between copper corrosion products and MX-80 bentonite

    International Nuclear Information System (INIS)

    The report presents results from a study of the possible interaction between copper corrosion products and MX-80 bentonite under conditions that might occur in a final repository for spent nuclear fuel in Finland. The first part of the report describes the results from a literature survey, the objective of which was to identify some relevant corrosion products that might form when copper corrodes in wet MX-80 bentonite. On the basis of the literature survey, atacamite and a green copper corrosion product produced in-house were used for experimental studies. Experiments were performed with both soft and compacted MX-80. The soft samples consisted of water-saturated MX-80 mixed with CuCl2 solutions of various concentrations. The samples were kept under anaerobic conditions at ambient room temperature or at 75 deg C for 330 days. Porewater samples were then squeezed from the samples and analysed. Compacted MX-80 samples were stored under anaerobic conditions and kept in contact with an NaCl solution. The samples were kept at room temperature and 75 deg C for 2.9 years and then analysed. The presence of either atacamite or the green copper corrosion product on the plates did not have any notable effects on the porewater chemistry. However, the Cu concentration profiles indicated that the corrosion products did dissolve, and then diffused into the surrounding bentonite. Concentration profiles were found to be roughly the same, irrespective of whether the samples had been stored at room temperature or at 75 deg C. (orig.)

  1. Natural and artefactual aneuploidy in human lymphocytes in extreme old age.

    Science.gov (United States)

    Lezhava, T; Khmaladze, E; Lokhadze, T; Buadze, T

    2008-04-01

    At present it is generally believed that aging is accompanied by an increase in the numbers of cells with altered chromosome sets. However, the problem of aneuploidy in extreme old age (80 years and over) has hardly been subjected to systematic investigation. The purpose of this study was to examine quantitative chromosome changes and relationship between "artefactual" and "natural" aneuploidy in subjects from 80 to 114 years of age using karyotype analyses. Chromosomes were studied in 1136 karyotypes of relatively round metaphases from 40 lymphocyte cultures obtained from 40 apparently normal subjects aged from 80 to 114 ( including 26 men and 14 women). 964 karyotypes from 48 donors aged 20 to 48 served as control. Lymphocytes were cultivation by modification method (Lezhava, 2006). It is suggested that the probability of natural aneuploidy rises substantially among elderly women; while that of artefactual aneuploidy is increased among elderly men; the problem of natural aneuploidy in males remains unclear.

  2. [EFFECT OF OVERWEIGHT AND OBESITY ON THE EQUILIBRIUM TIME, BUT NO IN THE TOTAL BODY WATER AND BODY COMPOSITION COMPARTMENTS IN WOMEN SUBJECTS OVER 60 YEARS OF AGE].

    Science.gov (United States)

    Lizárraga-Cañedo, Jonathan; Robles-Sardin, Alma; Salazar, Gabriela; Alemán-Mateo, Heliodoro

    2015-12-01

    Introducción: el envejecimiento y la obesidad producen cambios en la tasa de recambio de agua, lo que podría afectar al tiempo de equilibrio del óxido de deuterio (2H2O). Objetivo: se evaluó el efecto del sobrepeso y la obesidad sobre el tiempo de equilibrio del isótopo estable de deuterio en muestras de saliva de adultos mayores. Métodos: se incluyeron 18 mujeres entre 63 y 80 años con un índice de masa corporal (IMC) de 20,8 a 40,5 kg/m2. Después de la toma de una muestra de saliva basal se administró una dosis vía oral de 30 g de 2H2O. Se tomaron muestras de saliva a las 2, 2,5, 3, 3,5 y 4 horas post-dosis, las cuales fueron analizadas mediante espectrometría infrarroja con transformada de Fourier. Resultados: el tiempo de equilibrio (plateau) promedio en las mujeres con un IMC normal (18,5-24,9 kg/m2) fue de 3,6 ± 0,2 horas, el cual fue diferente estadísticamente al obtenido en el grupo con sobrepeso (25-29,9 kg/m2) y obesidad (>30 kg/m2) de 2,9 ± 0,4 horas y 2,8 ± 0,4 horas, respectivamente (p0,05). Conclusión: se encontró un efecto de la obesidad sobre el tiempo de equilibrio; sin embargo, no afectó al cálculo del agua corporal total y a la composición corporal en este grupo etario.

  3. UV, stress and aging

    OpenAIRE

    Debacq-Chainiaux, Florence; Leduc, Cedric; Verbeke, Alix; Toussaint, Olivier

    2014-01-01

    Skin is a model of choice in studies on aging. Indeed, skin aging can be modulated by internal and external factors, reflecting its complexity. Two types of skin aging have been identified: intrinsic, mainly genetically determined and extrinsic—also called "photo-aging"—resulting on the impact of environmental stress and more precisely of UV rays. Simplified in vitro models, based on cellular senescence, have been developed to study the relationship between UV and aging. These models vary on ...

  4. The over-55s and sexual orientation

    NARCIS (Netherlands)

    Jantine van Lisdonk; Lisette Kuyper

    2015-01-01

    Original title: 55-plussers en seksuele oriëntatie This report is about lesbian, gay and bisexual (LGB) people aged 55 and over in the Netherlands. Compared with earlier research, we find a striking number of correspondences between LGB and heterosexual people in this age group in terms of social

  5. "One and the Same the World Over": The International Culture of Surgical Exchange in an Age of Globalization, 1870-1914.

    Science.gov (United States)

    Schlich, Thomas

    2016-07-01

    This paper examines the international exchange in surgery in the decades before World War I, a period of growing globalization in communication and transport. Focusing on Europe and North America, it looks first at the various means of exchange, especially surgical travel and the culture emerging around it and follows specific directions of exchange, from France and Britain, first to the German-speaking countries and finally to North America. Subsequently, the account turns to international organizations as an important means of exchange in this time period. The International Society of Surgery, in particular, provided a forum for a vivid internationalist discourse, which, however, stood in tension with simultaneous nationalist tendencies leading up to World War I. The paper finally discusses how the international exchange and communication at the time can be seen as an instance of modern surgeons claiming-and simultaneously trying to create-the global universality of surgical knowledge and practices, making sure that surgery is the same the world over. PMID:26888942

  6. "One and the Same the World Over": The International Culture of Surgical Exchange in an Age of Globalization, 1870-1914.

    Science.gov (United States)

    Schlich, Thomas

    2016-07-01

    This paper examines the international exchange in surgery in the decades before World War I, a period of growing globalization in communication and transport. Focusing on Europe and North America, it looks first at the various means of exchange, especially surgical travel and the culture emerging around it and follows specific directions of exchange, from France and Britain, first to the German-speaking countries and finally to North America. Subsequently, the account turns to international organizations as an important means of exchange in this time period. The International Society of Surgery, in particular, provided a forum for a vivid internationalist discourse, which, however, stood in tension with simultaneous nationalist tendencies leading up to World War I. The paper finally discusses how the international exchange and communication at the time can be seen as an instance of modern surgeons claiming-and simultaneously trying to create-the global universality of surgical knowledge and practices, making sure that surgery is the same the world over.

  7. Aging related changes in determinants of muscle force generating capacity: a comparison of muscle aging in men and male rodents.

    Science.gov (United States)

    Ballak, Sam B; Degens, Hans; de Haan, Arnold; Jaspers, Richard T

    2014-03-01

    Human aging is associated with a progressive decline in skeletal muscle mass and force generating capacity, however the exact mechanisms underlying these changes are not fully understood. Rodents models have often been used to enhance our understanding of mechanisms of age-related changes in human skeletal muscle. However, to what extent age-related alterations in determinants of muscle force generating capacity observed in rodents resemble those in humans has not been considered thoroughly. This review compares the effect of aging on muscle force generating determinants (muscle mass, fiber size, fiber number, fiber type distribution and muscle specific tension), in men and male rodents at similar relative age. It appears that muscle aging in male F344*BN rat resembles that in men most; 32-35-month-old rats exhibit similar signs of muscle weakness to those of 70-80-yr-old men, and the decline in 36-38-month-old rats is similar to that in men aged over 80 yrs. For male C57BL/6 mice, age-related decline in muscle force generating capacity seems to occur only at higher relative age than in men. We conclude that the effects on determinants of muscle force differ between species as well as within species, but qualitatively show the same pattern as that observed in men.

  8. [Construction of age group vegetation index and preliminary application].

    Science.gov (United States)

    Xu, Zhang-hua; Li, Cong-hui; Liu, Jian; Yu, Kun-yong; Gong, Cong-hong; Tang, Meng-ya

    2014-06-01

    In the present paper, one remote sensing index-age group vegetation index (AGVI) was put forward, and its feasibility was verified. Taking 518 groups of pine forest age group data collected in 13 counties (cities) of Sanming, Jiangle, Shaxian, Nanping, Huaan, Yunxiao, Nanping, Anxi, Putian, Changting, Jianyang, Ningde and Fuqing, Fujian Province and HJ-1 CCD multi-spectral image at the same time-phase as the basis, the spectrum differences of blue, green, red, near infrared and NDVI of each age group were analyzed, showing the characteristics of young forest>middle-aged forest>over-mature forest>mature forest>near mature forest at near infrared band and mature forest>near mature forest>over-mature forest>young forest>middle-aged forest at NDVI, thus the age group vegetation index (AGVI) was constructed; the index could increase the absolute and relative spectrum differences among age groups. For the pine forest AGVI, cluster analysis was conducted with K-mean method, showing that the division accuracy of pine forest age group was 80.45%, and the accurate rate was 90.41%. Therefore, the effectiveness of age group vegetation index constructed was confirmed.

  9. Inflammation in Aging and Age-related Disease

    Directory of Open Access Journals (Sweden)

    Yuji Ikeno

    2011-12-01

    Full Text Available The San Antonio Nathan Shock Center Conferences have attracted international speakers and participants since 1995. This annual conference, held in Bandera, Texas, USA, addresses a different topic in the biology of aging each year. The venue's intimate setting, relatively remote location, and common areas are ideal for a small conference (80–100 participants, where copious informal intellectual interchange supplements that of the formal sessions. The 2011 meeting, part of an annual series sponsored by the University of Texas Health Science Center San Antonio, TX, USA, and the Nathan Shock Center of Excellence in the Biology of Aging, addressed the causes of age-associated inflammation and its effect on age-associated diseases.

  10. Insomnia in an 80-year-old population: relationship to medical, psychological and social factors.

    Science.gov (United States)

    Jensen, E; Dehlin, O; Hagberg, B; Samuelsson, G; Svensson, T

    1998-09-01

    In this study, insomnia in 80-year-olds was related to medical, psychological and social factors. The data were based on examinations every year in people aged between 80 and 89 years. Of 333 people living in the city of Lund and born in 1908, 67% participated. Increased severity of insomnia was significantly associated with use of diuretics, other cardiovascular drugs, hypnotics and laxatives, and with nervousness, difficulty relaxing, anorexia, nausea, constipation, backache, feeling cold, sweating, loss of weight, dizziness, depression, general fatigue, exhaustion, angina pectoris, cardiac insufficiency, worsened objective and subjective health, presence of negative T-waves on ECG, anxiety, total life satisfaction, neuroticism, disbelief in a just world, feeling lonely and lower survival rates. Thus insomnia has widespread associations with different aspects of life in 80-year-olds. PMID:9785273

  11. Prevalence of depression in general practice patients over 75 years of age

    OpenAIRE

    Jack, M.A.; Stobo, S.A.; Scott, L A; Sahgal, A.; Jachuck, S J

    1988-01-01

    The prevalence of depression among 74 male and 211 female patients aged 75 years or over registered with a group general practice was assessed, using the geriatric depression scale. Test scores of 0- 10, suggesting no depressive illness, were observed in 63 (85%) men and 172 (82%) women. Mild depression (scores 11-20) was observed in 10 (14%) men and 36(17%) women and severe depression (scores 21-30) in one (1%) man and three (1%) women. No significant statistical association was found with a...

  12. Successful Aging: Multiple Trajectories and Population Heterogeneity

    OpenAIRE

    2014-01-01

    Following Rowe and Kahn¡¯s successful aging model, this study identified successful aging as a distinctive aging trajectory and examined gender differences in the aging process. Using the Health and Retirement Study data (2000-2008), this study applied group-based trajectory analysis to identify multiple aging trajectories in a sample of older Americans aged 65 and over (N=9,226). Six dimensions were analyzed in the multi-trajectory model: chronic disease, physical functional limitation, disa...

  13. Microstructure evolution and effect on mechanical property in AZ80 Mg alloy during thermal processing

    Institute of Scientific and Technical Information of China (English)

    WANG Qiang; ZHANG Zhi-min; LI Bao-cheng; LI Xu-bin

    2006-01-01

    The microstructure and mechanical properties of AZ80 alloy were investigated during thermal processing. The samples of 4 mm in thickness machined from cast ingot were compressed at 300 ℃ with a thickness reduction of 75% and cooled in the water to room temperature. Then ageing(T5) and solution+ageing (T6) treatments were employed respectively. The results show that mechanical properties are significantly improved after thermal processing than those of as-cast AZ80 alloy due to grain refinement and discontinuous precipitates. The heat treatment has significant influence on microstructural evolution for sample formed at moderate temperature. Microstructural evaluation indicates that the β-phase increases because of sufficient solution and the alloy is strengthened evidently.

  14. Optimal Aging and Death

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan; Strulik, Holger

    the representative consumer is subject to physiological aging. In modeling aging we draw on recent research in the fields of biology and medicine. The speed of the aging process, and thus the time of death, are endogenously determined by optimal health investments. We calibrate the model to US data and proceed...

  15. Successful Aging and Longevity in Older Old Women: The Role of Depression and Cognition

    OpenAIRE

    Daniel Paulson; Mary Elizabeth Bowen; Lichtenberg, Peter A.

    2011-01-01

    Based in successful aging theory and terminal cognitive drop research, this paper investigates cerebrovascular burden (CVB), depressive symptoms, and cognitive decline as threats to longevity. A subsample of stroke-free women over the age of 80 was identified in the Health and Retirement Survey (years 2000–2008). Mortality at 2, 6, and 8 year intervals was predicted using CVB (diabetes, heart disease, hypertension), depressive symptoms (Center for Epidemiological Studies Depression Scale), an...

  16. Sex Differences in Medication and Primary Healthcare Use before and after Spousal Bereavement at Older Ages in Denmark: Nationwide Register Study of over 6000 Bereavements

    DEFF Research Database (Denmark)

    Oksuzyan, Anna; Jacobsen, Rune; Glaser, Karen;

    2011-01-01

    Background. The study aimed to examine sex differences in healthcare use before and after widowhood to investigate whether reduced healthcare use among widowers compared with widows may partially explain excess mortality and more adverse health outcomes among men than women after spousal loss. Me...

  17. Language and Aging.

    Science.gov (United States)

    Kemper, Susan; Anagnopoulos, Cheryl

    1989-01-01

    Reviews the effects of aging on language usage focusing on three areas of exploration: (1) changes in language in relation to changes in other cognitive abilities, (2) the linguistic consequences of normal aging versus those of dementia and aphasia, and (3) age-group differences in patterns of conversational interaction. (67 references) (GLR)

  18. Age and Farmer Productivity

    OpenAIRE

    Tauer, Loren W.

    1994-01-01

    Farmer productivity by age was estimated, allowing for differences because of efficiency and returns to scale. Using Census of Agriculture data, estimates vary by state, but returns to scale average 1.07. Efficiency increases average 4.5 percent every ten years of age, to the age interval 35 to 44, and then decreases at that same rate.

  19. Hodgkin's disease and age

    DEFF Research Database (Denmark)

    Specht, L.; Nissen, N.I.

    1989-01-01

    modality, stage, and total tumour burden, whereas age had no prognostic significance. With regard to death from Hodgkin's disease only age and total tumour burden had independent significance. The significance of age would seem to stem from the fact that some older patients could not be given adequate...

  20. Tetrahedral correlations in $^{80}$Zr and $^{98}$Zr

    CERN Document Server

    Zberecki, K; Heenen, P H; Schunck, N

    2006-01-01

    Axial and non-axial octupole correlations in $^{80}$Zr and $^{98}$Zr have been investigated using the generator coordinate method, applied to the basis generated by Skyrme HF+BCS calculations. We focus on the possible presence of a state with tetrahedral symmetry and on its stability with respect to octupole vibrations. We show that pairing and octupole correlations act in opposite ways and that a shallow mean-field tetrahedral minimum coexist with an axial octupole minimum. The contribution to the correlation energy coming from the tetrahedral degree of freedom and octupole axial deformation is calculated. We have calculated also the excitation energies of states associated with the tetrahedral vibrations.

  1. Preparation for Old Age in Different Life Domains: Dimensions and Age Differences

    Science.gov (United States)

    Kornadt, Anna E.; Rothermund, Klaus

    2014-01-01

    We investigated preparation for age-related changes from a multidimensional, life span perspective and administered a newly developed questionnaire to a large sample aged 30-80 years. Preparing for age-related changes was organized by life domains, with domain-specific types of preparation addressing obstacles and opportunities in the respective…

  2. [Home and dwelling arrangements in old age].

    Science.gov (United States)

    Dapp, Ulrike; von Renteln-Kruse, Wolfgang

    2015-10-01

    The increase of life expectancy provides the unique opportunity to participate actively in social life many years after retirement and upbringing of children. In Germany, over 80 % of the population 60 years and older are living independently in the community, and approximately 95 % stay in their own homes. On the other hand, the probability to suffer from diseases, frailty and impaired activities of daily life activities also rises with higher age. However, only on rare occasions older people in need of nursing care do like to give up their home voluntarily. Next to innovative forms of dwelling, home replacement, technical aids and us of information and communication technology (ICT), efforts to strengthen the older persons' independence of maintaining mobility in their home environment (life space) is emphasised in this article. The particular focus is on the use of preventative strategies and to support geriatric network facilities. PMID:26445251

  3. Reasons for playing casual video games and perceived benefits among adults 18 to 80 years old.

    Science.gov (United States)

    Whitbourne, Susan Krauss; Ellenberg, Stacy; Akimoto, Kyoko

    2013-12-01

    Casual video games (CVGs) are becoming increasingly popular among middle-aged and older adults, yet there are few studies documenting why adults of different ages play these games, what benefits they perceive, and how regularly they play. The present study compared the online survey responses of 10,308 adults ranging from 18 to 80 years of age to questions regarding PopCap's popular free online game, Bejeweled Blitz (BJB). All respondents cited playing against friends as their main reason for playing. However, there were differences by age in the second most frequently cited reason. Middle-aged adults cited stress relief, and older adults reported that they seek the game's challenges. As a result of playing CVGs, younger adults noted that they felt sharper and experienced improved memory; older adults were more likely to feel that their visuospatial skills and response time benefited. Adults aged 60 and older had heavier patterns of game play than did adults under the age of 60 years. A significant number of respondents (14.7%) spontaneously noted that they felt that BJB had addictive qualities. CVG players seem to be drawn into this activity by its social nature and to a certain extent by its reinforcing properties. Once involved, however, they believe that they derive a number of benefits that, for older adults, appear to offset declines in age-sensitive cognitive functions.

  4. Reasons for playing casual video games and perceived benefits among adults 18 to 80 years old.

    Science.gov (United States)

    Whitbourne, Susan Krauss; Ellenberg, Stacy; Akimoto, Kyoko

    2013-12-01

    Casual video games (CVGs) are becoming increasingly popular among middle-aged and older adults, yet there are few studies documenting why adults of different ages play these games, what benefits they perceive, and how regularly they play. The present study compared the online survey responses of 10,308 adults ranging from 18 to 80 years of age to questions regarding PopCap's popular free online game, Bejeweled Blitz (BJB). All respondents cited playing against friends as their main reason for playing. However, there were differences by age in the second most frequently cited reason. Middle-aged adults cited stress relief, and older adults reported that they seek the game's challenges. As a result of playing CVGs, younger adults noted that they felt sharper and experienced improved memory; older adults were more likely to feel that their visuospatial skills and response time benefited. Adults aged 60 and older had heavier patterns of game play than did adults under the age of 60 years. A significant number of respondents (14.7%) spontaneously noted that they felt that BJB had addictive qualities. CVG players seem to be drawn into this activity by its social nature and to a certain extent by its reinforcing properties. Once involved, however, they believe that they derive a number of benefits that, for older adults, appear to offset declines in age-sensitive cognitive functions. PMID:23971430

  5. UV, stress and aging.

    Science.gov (United States)

    Debacq-Chainiaux, Florence; Leduc, Cedric; Verbeke, Alix; Toussaint, Olivier

    2012-07-01

    Skin is a model of choice in studies on aging. Indeed, skin aging can be modulated by internal and external factors, reflecting its complexity. Two types of skin aging have been identified: intrinsic, mainly genetically determined and extrinsic-also called "photo-aging"-resulting on the impact of environmental stress and more precisely of UV rays. Simplified in vitro models, based on cellular senescence, have been developed to study the relationship between UV and aging. These models vary on the cell type (fibroblasts or keratinocytes, normal or immortalized) and the type of UV used (UVA or UVB). PMID:23467762

  6. UV, stress and aging.

    Science.gov (United States)

    Debacq-Chainiaux, Florence; Leduc, Cedric; Verbeke, Alix; Toussaint, Olivier

    2012-07-01

    Skin is a model of choice in studies on aging. Indeed, skin aging can be modulated by internal and external factors, reflecting its complexity. Two types of skin aging have been identified: intrinsic, mainly genetically determined and extrinsic-also called "photo-aging"-resulting on the impact of environmental stress and more precisely of UV rays. Simplified in vitro models, based on cellular senescence, have been developed to study the relationship between UV and aging. These models vary on the cell type (fibroblasts or keratinocytes, normal or immortalized) and the type of UV used (UVA or UVB).

  7. Social, environmental and psychological factors associated with objective physical activity levels in the over 65s.

    Directory of Open Access Journals (Sweden)

    Marion E T McMurdo

    Full Text Available OBJECTIVE: To assess physical activity levels objectively using accelerometers in community dwelling over 65 s and to examine associations with health, social, environmental and psychological factors. DESIGN: Cross sectional survey. SETTING: 17 general practices in Scotland, United Kingdom. PARTICIPANTS: Random sampling of over 65 s registered with the practices in four strata young-old (65-80 years, old-old (over 80 years, more affluent and less affluent groups. MAIN OUTCOME MEASURES: Accelerometry counts of activity per day. Associations between activity and Theory of Planned Behaviour variables, the physical environment, health, wellbeing and demographic variables were examined with multiple regression analysis and multilevel modelling. RESULTS: 547 older people (mean (SD age 79(8 years, 54% female were analysed representing 94% of those surveyed. Accelerometry counts were highest in the affluent younger group, followed by the deprived younger group, with lowest levels in the deprived over 80 s group. Multiple regression analysis showed that lower age, higher perceived behavioural control, the physical function subscale of SF-36, and having someone nearby to turn to were all independently associated with higher physical activity levels (R(2 = 0.32. In addition, hours of sunshine were independently significantly associated with greater physical activity in a multilevel model. CONCLUSIONS: Other than age and hours of sunlight, the variables identified are modifiable, and provide a strong basis for the future development of novel multidimensional interventions aimed at increasing activity participation in later life.

  8. Emotional experience improves with age: evidence based on over 10 years of experience sampling.

    Science.gov (United States)

    Carstensen, Laura L; Turan, Bulent; Scheibe, Susanne; Ram, Nilam; Ersner-Hershfield, Hal; Samanez-Larkin, Gregory R; Brooks, Kathryn P; Nesselroade, John R

    2011-03-01

    Recent evidence suggests that emotional well-being improves from early adulthood to old age. This study used experience-sampling to examine the developmental course of emotional experience in a representative sample of adults spanning early to very late adulthood. Participants (N = 184, Wave 1; N = 191, Wave 2; N = 178, Wave 3) reported their emotional states at five randomly selected times each day for a one week period. Using a measurement burst design, the one-week sampling procedure was repeated five and then ten years later. Cross-sectional and growth curve analyses indicate that aging is associated with more positive overall emotional well-being, with greater emotional stability and with more complexity (as evidenced by greater co-occurrence of positive and negative emotions). These findings remained robust after accounting for other variables that may be related to emotional experience (personality, verbal fluency, physical health, and demographic variables). Finally, emotional experience predicted mortality; controlling for age, sex, and ethnicity, individuals who experienced relatively more positive than negative emotions in everyday life were more likely to have survived over a 13 year period. Findings are discussed in the theoretical context of socioemotional selectivity theory.

  9. Emotional experience improves with age: evidence based on over 10 years of experience sampling.

    Science.gov (United States)

    Carstensen, Laura L; Turan, Bulent; Scheibe, Susanne; Ram, Nilam; Ersner-Hershfield, Hal; Samanez-Larkin, Gregory R; Brooks, Kathryn P; Nesselroade, John R

    2011-03-01

    Recent evidence suggests that emotional well-being improves from early adulthood to old age. This study used experience-sampling to examine the developmental course of emotional experience in a representative sample of adults spanning early to very late adulthood. Participants (N = 184, Wave 1; N = 191, Wave 2; N = 178, Wave 3) reported their emotional states at five randomly selected times each day for a one week period. Using a measurement burst design, the one-week sampling procedure was repeated five and then ten years later. Cross-sectional and growth curve analyses indicate that aging is associated with more positive overall emotional well-being, with greater emotional stability and with more complexity (as evidenced by greater co-occurrence of positive and negative emotions). These findings remained robust after accounting for other variables that may be related to emotional experience (personality, verbal fluency, physical health, and demographic variables). Finally, emotional experience predicted mortality; controlling for age, sex, and ethnicity, individuals who experienced relatively more positive than negative emotions in everyday life were more likely to have survived over a 13 year period. Findings are discussed in the theoretical context of socioemotional selectivity theory. PMID:20973600

  10. Estimation of aerosol radiative forcing over an aged-background aerosol feature during advection and non-advection events using a ground-based data obtained from a Prede Skyradiometer observation

    Science.gov (United States)

    Ningombam, Shantikumar S.; Bagare, S. P.; Khatri, P.; Sohn, B. J.; Song, H.-J.

    2015-10-01

    Estimation of aerosol radiative forcing (ARF) was performed using a radiative transfer model (Rstar6b) along with physical and optical parameters of aerosols obtained from sky radiometer observation over Indian Astronomical Observatory (IAO), Hanle, Ladakh, during 2008-2010 from dust, anthropogenic, and aged background observing conditions. ARF was estimated at the top of the atmosphere (TOA), in the atmosphere, and at the surface during the three observing conditions. During dust and anthropogenic events, average aerosol optical depth (AOD at 500 nm) went up to 0.24 from the aged background observing condition 0.04. Such enhancement of AOD is associated by the combination of desert-dust and anthropogenic aerosols transported from distant sources as noticed from Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO). Such three types of aerosols are also identified from the observed properties of single scattering albedo (SSA), aerosol asymmetry (AS) parameter, and aerosol size distribution. The estimated ARFs at TOA, at the surface, and in atmosphere are - 3.73, - 6.82, and 3.40 Wm- 2, respectively during the dust advection period. On the contrary, the respective ARFs during the aged background observing condition are - 1.50, - 2.22, and 0.70 Wm- 2, respectively. A significant difference of spectral AOD is observed during dust, anthropogenic, and aged background observing conditions. Ångström exponent (AE) decreases from 1.05 in the aged background observing condition to 0.40 in the dust event. A significant difference of coarse-fine mode volume distribution is also observed between the dust and the anthropogenic cases. Further, the study reveals high aerosols induced during the dust and the anthropogenic episodes caused warming at atmosphere and cooling at surface which collectively may affect the local atmospheric circulation.

  11. Risk factors for urinary incontinence in Taiwanese women aged 60 or over.

    Science.gov (United States)

    Hsieh, Ching-Hung; Hsu, Chun-Sen; Su, Tsung-Hsien; Chang, Shao-Tung; Lee, Meng-Chih

    2007-11-01

    To determine risk factors of urinary incontinence (UI) in Taiwanese women aged 60 or over, face-to-face interviews with 1,517 women, selected by a multistage random method, were completed. The prevalence of UI in this age group was 29.8%. Factors and their prevalence associated with UI were age [odds ratio (OR)=1.04 per year], diabetes mellitus (39.8%, p = 0.002), hypertension (39.5%, p = 0.001), abdominal gynecological surgery (41.4%, p = 0.001), hysterectomy (42.4%, p = 0.003), history of drug allergy (41.3%, p = 0.001), smoking (45.5%, p = 0.010), hormone replacement therapy (41.5%, p = 0.026), and high body mass index (OR = 1.05 per unit). Alcohol consumption and marriage did not increase the risk of UI. UI is a common and costly problem in elderly women. It diminishes the quality of life of the affected women. Of the associated factors that are preventable, modifiable, or controllable, smoking, prior hysterectomy, and obesity may have the greatest impact on the prevalence of UI.

  12. Thermodynamic structure of the marine atmosphere over the region 80-87°E along 13°N during August (phase II) BOBMEX-99

    Indian Academy of Sciences (India)

    Savita B Morwal; P Seetaramayya

    2003-06-01

    Thermodynamic structure of the marine atmosphere in the region between 80 and 87°E along 13°N over the Bay of Bengal was studied using 13 high resolution radiosonde profiles from surface −400 hPa collected onboard ORV Sagar Kanya during the period 27th-30th August, during BOBMEX-99. Saturation point concept, mixing line analysis and conserved variable diagrams have been used to identify boundary layer characteristics such as air mass movement and stability of the atmosphere. The results showed relatively dry air near the ocean surface between 1000 and 950 hPa. This feature is confirmed by the conserved v structure in this layer. Further, v seldom showed any inversions in this region. The e and es profiles showed persistent low cloud layers between 900 and 700 hPa. The conserved variable diagrams (e-q) showed the existence of double mixing line structures approximately at 950 and 700 hPa levels.

  13. Risk factors associated with postpartum hemorrhage among uniparas aged over 35 years from one grade 3 and first-class obstetrics and gynecology hospital of Beijing%北京市某三级甲等妇产专科医院高龄初产妇产后出血的影响因素分析

    Institute of Scientific and Technical Information of China (English)

    张红卫; 郭利; 张力亚

    2013-01-01

    目的 了解高龄初产妇产后出血的发生率及其危险因素.方法 对北京妇产医院2011年6月至2012年5月住院分娩的1 065例高龄产妇的住院病例资料进行回顾性分析,采用多因素Logistic回归模型分析高龄初产妇产后出血的危险因素.结果 高龄初产妇产后出血的发生率为15.02%.多因素Logistic回归分析显示以下因素与高龄初产妇的产后出血有关:宫缩乏力(AOR>999.999)、前置胎盘(AOR:24.72;95% CI:4.82~126.80)、试管婴儿(AOR:5.79;95% CI:1.50~22.31)、足月产(AOR:0.26;95% CI:0.07~0.96).结论 高龄初产妇是产后出血的高危人群,确认危险因素,加强宣教,及早治疗有助于降低产妇的产后出血率及死亡率.%Objective To determine the incidence and risk factors of postpartum hemorrhage among uniparas aged 35 years or older.Methods This hospital-based study included 1 065 advanced maternal age between June 2011 and May 2012 from Beijing Obstetrics and Gynecology Hospital.A multiple logistic model was used to identify risk factors independently associated postpartum hemorrhage among the pregnancy women aged over 35 years.Results The incidence of postpartum hemorrhage was 15%.Multiple Logistic analysis results showed that uterine atony (AOR >999.999),placenta previa (AOR:24.72 ;95% CI:4.82-126.80),test-tube baby (AOR:5.79 ; 95 % CI:1.50-22.31),and term infants (AOR:0.26 ; 95 % CI:0.07-0.96)were the risk factors for uniparas aged over 35 years.Conclusions Uniparas aged over 35 years are high-risk groups for postpartum hemorrhage.So doctors and nurses should identify the risk factors for postpartum hemorrhage of uniparas aged over 35 years,emphasize health education and provide early treatment so that the rote of postpartum hemorrhage and the mortality of pregnancy women can be reduced.

  14. Prediction of Age at Menopause in Women of Suburban Areas in Chennai Using A Model of Fsh Over Age - A Pilot Study

    Directory of Open Access Journals (Sweden)

    SM Priyadharshini

    2014-02-01

    Full Text Available Objectives: The human ovary is characterized by early senescence and the end stage of ovarian activity is termed menopause. The age at which menopause occur is between 45 and 55 years world wide. The objective of this pilot study is to determine the age at menopause by using a model of FSH over age in women of sub urban region around Chennai, India. Materials and Methods: The subjects include 500 patients of age between 30 and 36 yrs with BMI ranging from 24-28.After recording their general profile and history, blood samples were obtained by venipuncture and hormone FSH was estimated on the day 3 of the menstrual cycle. Based on functional dependence of FSH in the form of exponential relation with age, a model was proposed. Using least square approximation the beta values were calculated. Results: With the help of beta values and using the cut off value of 40 IU/ml for FSH, this predicted model determined the age of menopause as 44.6yrs in women of sub urban region around Chennai. Conclusion: The age of menopause is different in various region worlds wide. According to this pilot study the suburban women of Chennai, attain menopause at an age of 44.6 years. Further exploration should be done to alleviate the role of diet, life style and ethnic variation on menopausal age and the impact of chronic disease like osteoporosis during the period of menopause.

  15. Comparison of performance-based measures among native Japanese, Japanese-Americans in Hawaii and Caucasian women in the United States, ages 65 years and over: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Hayashi Takuo

    2001-10-01

    Full Text Available Abstract Background Japanese (both in Japan and Hawaii have a lower incidence of falls and of hip fracture than North American and European Caucasians, but the reasons for these differences are not clear. Subjects and Methods A cross-sectional study. We compared neuromuscular risk factors for falls using performance-based measures (chair stand time, usual and rapid walking speed, and grip strength among 163 Japanese women in Japan, 681 Japanese-American women in Hawaii and 9403 Caucasian women in the United States aged 65 years and over. Results After adjusting for age, the Caucasian women required about 40% more time to complete 5 chair stands than either group of Japanese. Walking speed was about 10% slower among Caucasians than native Japanese, whereas Japanese-American women in Hawaii walked about 11% faster than native Japanese. Grip strength was greatest in Japan, which may reflect the rural farming district that this sample was drawn from. Additional adjustment for height, weight or body mass index increased the adjusted means of chair stand time and grip strength among Japanese, but the differences remained significant. Conclusions Both native Japanese and Japanese-American women in Hawaii performed better than Caucasians on chair stand time and walking speed tests, and native Japanese had greater grip strength than Japanese in Hawaii and Caucasians. The biological implications of these differences in performance are uncertain, but may be useful in planning future comparisons between populations.

  16. Navigating Hardships in Old Age: Exploring the Relationship Between Spirituality and Resilience in Later Life

    OpenAIRE

    Manning, Lydia K.

    2013-01-01

    Research suggests that spirituality is important to a large percentage of the older adult population and serves as a promoter of healthy aging. In this qualitative research I conducted and analyzed multiple interviews with 6 women aged 80 and older. Using multiple in-depth interviews I explored the interplay between spirituality and resilience over the life course. A grounded theory analysis of the 30 interviews was performed. The major finding is that participants used their spirituality as ...

  17. Aging and cosmetic enhancement

    OpenAIRE

    Honigman, Roberta; David J. Castle

    2006-01-01

    Obsession with a youthful appearance has become commonplace in modern society and has resulted in an upswing in cosmetic procedures trying to reverse the aging process. We selectively review the literature on aging and cosmetic surgery, with particular regard for the aging face. We pay attention to psychosocial aspects of response to such cosmetic procedures, both in terms of outcome and with respect to risk factors for a poor outcome.

  18. Climate change or urbanization? Impacts on a traditional coffee production system in East Africa over the last 80 years.

    Directory of Open Access Journals (Sweden)

    Juliana Jaramillo

    Full Text Available Global environmental changes (GEC such as climate change (CC and climate variability have serious impacts in the tropics, particularly in Africa. These are compounded by changes in land use/land cover, which in turn are driven mainly by economic and population growth, and urbanization. These factors create a feedback loop, which affects ecosystems and particularly ecosystem services, for example plant-insect interactions, and by consequence agricultural productivity. We studied effects of GEC at a local level, using a traditional coffee production area in greater Nairobi, Kenya. We chose coffee, the most valuable agricultural commodity worldwide, as it generates income for 100 million people, mainly in the developing world. Using the coffee berry borer, the most serious biotic threat to global coffee production, we show how environmental changes and different production systems (shaded and sun-grown coffee can affect the crop. We combined detailed entomological assessments with historic climate records (from 1929-2011, and spatial and demographic data, to assess GEC's impact on coffee at a local scale. Additionally, we tested the utility of an adaptation strategy that is simple and easy to implement. Our results show that while interactions between CC and migration/urbanization, with its resultant landscape modifications, create a feedback loop whereby agroecosystems such as coffee are adversely affected, bio-diverse shaded coffee proved far more resilient and productive than coffee grown in monoculture, and was significantly less harmed by its insect pest. Thus, a relatively simple strategy such as shading coffee can tremendously improve resilience of agro-ecosystems, providing small-scale farmers in Africa with an easily implemented tool to safeguard their livelihoods in a changing climate.

  19. Older Women's Development: A Comparison of Women in Their 60s and 80s on a Measure of Erikson's Developmental Tasks.

    Science.gov (United States)

    Norman, Suzanne M.; McCluskey-Fawcett, Kathleen; Ashcraft, Lisa

    2002-01-01

    Compares women from two ages groups in order to understand their development across the life span. Measures of Psychosocial Development, which assesses Erikson's developmental stages, were administered to 41 women in 2 cohorts (ages 60-70, ages 80-90). Age group differences in the resolution of Erikson's identity and trust developmental tasks were…

  20. Wavelength conversion from C- to L-band at 10 Gbit/s including transmission over 80 km of SSMF

    DEFF Research Database (Denmark)

    Poulsen, Henrik Nørskov; Buxens Azcoaga, Alvaro Juan; Clausen, Anders;

    2000-01-01

    As the need for capacity increases, means to accommodate the growth is getting increasingly important. Hence, higher bit rates and an ever increasing number of WDM channels is being employed. This has led to the introduction of the L-band (ranging from 1570 to 1610 nm) as the new transmission win...

  1. Age, wage and productivity

    OpenAIRE

    van Ours, J.C.; Stoeldraijer, L.

    2010-01-01

    Previous empirical studies on the effect of age on productivity and wages find contradicting results. Some studies find that if workers grow older there is an increasing gap between productivity and wages, i.e. wages increase with age while productivity does not or does not increase at the same pace. However, other studies find no evidence of such an age related pay-productivity gap. We perform an analysis of the relationship between age, wage and productivity using a matched worker-firm pane...

  2. Hodgkin's disease and age

    DEFF Research Database (Denmark)

    Specht, L; Nissen, N I

    1989-01-01

    506 unselected, previously untreated patients with Hodgkin's disease were treated at the Finsen Institute between 1969 and 1983. The prognostic significance of age, sex, stage, systemic symptoms, histologic subtype, number of involved nodal regions, total tumour burden (peripheral + intrathoracic...... modality, stage, and total tumour burden, whereas age had no prognostic significance. With regard to death from Hodgkin's disease only age and total tumour burden had independent significance. The significance of age would seem to stem from the fact that some older patients could not be given adequate...

  3. The Big-Fish-Little-Pond Effect: Generalizability of Social Comparison Processes over Two Age Cohorts from Western, Asian, and Middle Eastern Islamic Countries

    Science.gov (United States)

    Marsh, Herbert W.; Abduljabbar, Adel Salah; Morin, Alexandre J. S.; Parker, Philip; Abdelfattah, Faisal; Nagengast, Benjamin; Abu-Hilal, Maher M.

    2015-01-01

    Extensive support for the seemingly paradoxical negative effects of school- and class-average achievement on academic self-concept (ASC)-the big-fish-little-pond effect (BFLPE)--is based largely on secondary students in Western countries or on cross-cultural Program for International Student Assessment studies. There is little research testing the…

  4. Alexithymia and overeating.

    Science.gov (United States)

    Wheeler, K; Broad, R D

    1994-01-01

    While obesity is a complex, multidetermined disorder, a significant subgroup of overeaters suffer from alexithymia, which contributes to weight gain and difficulties in losing weight. For these individuals, food is used to regulate tension and inner-feeling states. The authors advocate psychotherapy aimed toward helping clients differentiate feelings and develop the capacity for symbolization as the most effective treatment. PMID:7532296

  5. Advancements in design and analysis of system 80+TM

    International Nuclear Information System (INIS)

    The System 80+ power plant design is now in the final stages of the US Nuclear Regulatory Commission's review leading to certification as a complete power plant integrated for safe and reliable operation. The topics covered in this presentation include: results from the use of the revised source term of NUREG 1465; reduction of the large release frequency to well within the U.S. NRC's Severe Accident Policy goals; results of the shutdown probabilistic risk assessment; significantly improved defense-in-depth against software defects using non-safety backup control systems; the application of leak-before-break technology to various high-pressure piping; and the use of a seismic envelope. 8 refs., 1 tab., 2 figs

  6. Structure and Thermal Parameters of Ni20Pd80 Alloy

    Institute of Scientific and Technical Information of China (English)

    S. Ahmad; A.B. Ziya; A. Aziz1; Z.I. Zafar

    2009-01-01

    The structure and thermal parameters of Ni20Pd80 alloy were studied by X-ray diffraction(XRD). The diffraction experiments performed in the temperature range of 308-1100 K revealed that the alloy formed a face centered cubic (fcc) Al-type structure. The temperature dependence of the lattice parameters was investigated by using the Bragg line displacement method showing that the lattice parameter increases with the increase of temperature. The mean linear thermal expansion (MLTE(%)), coefficient of thermal expansion (CTE, α), the characteristic Debye temperature (θD) and mean square amplitudes of vibration were determined from XRD data. The value of Debye temperature was found to be 253 K. It was found that temperature factor was independent of the static displacements.

  7. Ageing between Gerontology and Biomedicine

    NARCIS (Netherlands)

    Moreira, Tiago; Palladino, Paolo

    2009-01-01

    Over the past two decades, public interest in the basic biological processes underlying the phenomenon of ageing has grown considerably. New developments in biotechnology and health maintenance programmes appear to be forging new relationships between biology, medicine and the lives of older people.

  8. Over and under

    Energy Technology Data Exchange (ETDEWEB)

    Woof, M.

    2004-04-01

    Power is a vital issue in underground haulage equipment. High power outputs are now being achieved from smaller, more fuel-efficient engines that produce fewer emissions, paving the way for compact trucks with faster speeds and/or bigger payloads. The article highlights developments by manufacturers in the small to mid sized truck sector - Bird Machines, Cat, Dux, EJC and MTI. Bird Machines SRET15 is a 15-tonne truck featuring a novel rear ejection system, for use in gassy coal mines. Other trucks mentioned include Cat's AD30 UAT, Dux's ET33 ejector truck and EJC's Ramp Rabbit trucks. Engine developments have made a big impact on the 50 tonnes and above class, with Dux moving into compete with the likes of Atlas Copco Wagner, Caterpillar, Kiruna Truck and Sandbik Tamrock. 4 photos.

  9. Aging, longevity and health

    DEFF Research Database (Denmark)

    Rasmussen, Lene Juel; Sander, Miriam; Wewer, Ulla M.;

    2011-01-01

    Session included speeches by Ralf Hemmingsen, Ulla Wewer, and Lene Juel Rasmussen and Keynote Addresses by four world renowned aging researchers: Povl Riis (The Age Forum), Bernard Jeune (University of Southern Denmark), George Martin (University of Washington, USA) and Jan Vijg (Albert Einstein School...

  10. Aging, Trade, and Migration

    OpenAIRE

    Chisik, Richard; Onder, Harun; Qirjo, Dhimitri

    2016-01-01

    This study considers the role of demand-driven changes arising from population aging and how they affect the pattern of international trade as well as trade and immigration policy. An aging society can see a welfare-reducing reduction in its share of manufacturing output and this reduction is magnified by a decrease in trade costs (an increase in globalization). Immigration can ameliorate ...

  11. The 80-hour Work Week for Residents: Views from Obstetric and Gynecology Program Directors

    OpenAIRE

    Janoo, Jabin; Hashmi, Mahreen; Seybold, Dara J.; Shapiro, Robert; Calhoun, Byron C.; Bush, Stephen H.

    2014-01-01

    In 2003, the Accreditation Council for Graduate Medical Education mandated an 80-hour work week restriction for residency programs. We examined program directors’ views on how this mandate affects the education of Obstetrics and Gynecology residents. A 25 question survey was administered via Survey Monkey to Obstetrics and Gynecology program directors in the United States over three months in 2011. Fifty program directors (response rate of 28%) completed it with more men (62%) than women (38%...

  12. Telomeres and reproductive aging.

    Science.gov (United States)

    Keefe, David L; Liu, Lin

    2009-01-01

    Infertility, miscarriage and aneuploid offspring increase with age in women, and meiotic dysfunction underlies reproductive aging. How aging disrupts meiotic function in women remains unclear, but as women increasingly delay having children, solving this problem becomes an urgent priority. Telomeres consist of a (TTAGGG)(n) repeated sequence and associated proteins at chromosome ends, mediate aging in mitotic cells and may also mediate aging during meiosis. Telomeres shorten both during DNA replication and from the response to oxidative DNA damage. Oocytes do not divide in adult mammals, but their precursors do replicate during fetal oogenesis; eggs ovulated from older females have traversed more mitotic cell cycles before entering meiosis during fetal oogenesis than eggs ovulated from younger females. Telomeres also would be expected to shorten from inefficient DNA repair of oxidative damage, because the interval between fetal oogenesis and ovulation is exceptionally prolonged in women. We have tested the hypothesis that telomere shortening disrupts meiosis by shortening telomeres experimentally in mice, which normally do not exhibit age-related meiotic dysfunction. Interestingly, mouse telomeres are much longer than human telomeres, but genetic or pharmacological shortening of mouse telomeres recapitulates in mice the human reproductive aging phenotype as the mouse telomeres reach the length of telomeres from older women. These observations led us to propose a telomere theory of reproductive aging. Moreover, chronological oxidative stress increases with reproductive aging, leading to DNA damage preferentially at (TTAGGG)(n) repeats. Finally, if telomeres shorten with aging, how do they reset across generations? Telomerase could not play a significant role in telomere elongation during early development, because this enzyme is not active until the blastocyst stage, well after the stage when telomere elongation takes place. Rather, telomeres lengthen during the

  13. Age Is No Longer a Limit: Two Cases of Hepatectomy in Patients Over 90 Years Old

    Directory of Open Access Journals (Sweden)

    Shugo Uwatoko

    2015-02-01

    Full Text Available Hepatocellular carcinoma (HCC is a common malignant tumor with poor prognosis. The age of patients affected by HCC is considered to be increasing, and several studies have reported significantly higher rates of morbidity and mortality after hepatectomy for HCC in elderly patients. However, other studies have reported that the short- and long-term outcomes of surgery for HCC in elderly patients are similar to those in younger patients. Whether the indications for hepatic resection in elderly patients resemble those in younger patients has thus been questioned. We describe two cases of patients over 90 years old who underwent major hepatectomy for HCC, representing the oldest patients in the world to have done so.

  14. Age, Wage and Productivity

    NARCIS (Netherlands)

    van Ours, J.C.; Stoeldraijer, L.

    2010-01-01

    Previous empirical studies on the effect of age on productivity and wages find contradicting results. Some studies find that if workers grow older there is an increasing gap between productivity and wages, i.e. wages increase with age while productivity does not or does not increase at the same pace

  15. 40 CFR 80.219 - Designation and downstream requirements for GPA gasoline.

    Science.gov (United States)

    2010-07-01

    ... requirements for GPA gasoline. 80.219 Section 80.219 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY...-in Program § 80.219 Designation and downstream requirements for GPA gasoline. The requirements and... standards under § 80.216 as “GPA” gasoline. (b) Product transfer documents. (1) On each occasion that...

  16. 高龄白内障患者超声乳化术的护理%Nursing care of cataract phacoemulsification in elderly patients over 80 years old

    Institute of Scientific and Technical Information of China (English)

    傅学侠; 赵长龙

    2011-01-01

    目的 评价高龄白内障患者行超声乳化吸除联合人工晶状体植入术围手术期护理的效果. 方法 2007年4月以来,对41例(41只眼)80岁以上的白内障患者行白内障超声乳化吸除联合人工晶状体植入.完善术前检查,注意监测术中全身情况,加强患者围手术期的护理及指导. 结果 41例(41只眼)高龄白内障患者手术顺利,术后视力恢复较好,未出现严重的全身及眼部并发症,患者满意. 结论 高龄白内障患者施行超声乳化术,经认真手术准备,做好围手术期护理,可降低手术的风险,取得满意的效果.%Objective To evaluate the perioperative nursing effect of phacoemulsification and monofocal introcular lens IOL implanation in elderly patients. Methods 41 patients ( 41 eyes )over eighty years old were treated with phacoemulsification and monofocal IOL implanation. The carfully carried out peroperative examination, closely monitored the systemic situation during the operation, strengthened perioperative nursing and guidance to the patients. Results Fourty-one cases of elderly patients were satisfied with result. There were no serious systemic and ocular complications. Conclusion Elderly patients of venerable eye treated with phacoemulsification and monofocal IOL implanation, improved the preoperative preparation strengthened perioperative nursing can reduce risk for the operation and achieve a satisfactory therapeutic effect.

  17. Changes in access to structural social capital and its influence on self-rated health over time for middle-aged men and women: a longitudinal study from northern Sweden.

    Science.gov (United States)

    Eriksson, Malin; Ng, Nawi

    2015-04-01

    Until recently, most studies on social capital and health have been cross-sectional making it difficult to draw causal conclusions. This longitudinal study used data from 33,621 individuals (15,822 men and 17,799 women) from the Västerbotten Intervention Program, to analyse how changes in access to individual social capital influence self-rated health (SRH) over time. Two forms of structural social capital, i.e. informal socializing and social participation, were measured. Age, sex, education, marital status, smoking, snuff, physical activity, alcohol consumption, high blood pressure, and body mass index were analysed as potential confounders. The association between changes in access to structural social capital and SRH in the follow-up was adjusted for SRH at baseline, as well as for changes in the socio-demographic and health-risk variables over time. The results support that changes in access to structural social capital over time impact on SRH. Remaining with no/low level of informal socializing over time increased the odds ratio for poor SRH for both men and women (OR of 1.45; 95%CI = 1.22-1.73 among men and OR of 1.56; 95%CI = 1.33-1.84 among women). Remaining with no/low levels of social participation was also detrimental to SRH in men and women (OR 1.14; 95%CI = 1.03-1.26 among men and OR 1.18; 95%CI = 1.08-1.29 among women). A decrease in informal socializing over time was associated with poor SRH for women and men (OR of 1.35; 95%CI = 1.16-1.58 among men and OR of 1.57; 95%CI = 1.36-1.82 among women). A loss of social participation had a negative effect on SRH among men and women (OR of 1.16; 95%CI = 1.03-1.30 among men and OR of 1.15; 95%CI = 1.04-1.27 among women). Gaining access to social participation was harmful for SRH for women (OR 1.17; 95%CI = 1.05-1.31). Structural social capital has complex and gendered effects on SRH and interventions aiming to use social capital for health promotion purposes require an awareness of its gendered nature.

  18. Optimal Aging and Death

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan Lars; Strulik, Holger

    2010-01-01

    expectancy in the same year ("the Preston curve"); cross-country income differences can explain differences in life expectancy at age 20 of up to a decade. Moreover, technological change in health care of about 1.1% per year can account for the observed shift in the Preston curve between 1980 and 2000.......This study introduces physiological aging into a simple model of optimal intertemporal consumption. In this endeavor we draw on the natural science literature on aging. According to the purposed theory, the speed of the aging process and the time of death are endogenously determined by optimal...... health investments. At the same time, physiological aspects of the aging process inuence optimal savings and health investment. We calibrate the model for the average US male in 2000 and proceed to show that the calibrated model accounts well for the cross-country link between labor productivity and life...

  19. Optimal Aging and Death

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan Lars; Strulik, Holger

    2010-01-01

    and life expectancy in the same year ("the Preston curve"); cross-country income differences can explain differences in life expectancy at age 20 of up to a decade. Moreover, technological change in health care of about 1.1% per year can account for the observed shift in the Preston curve between 1980......This study introduces physiological aging into a simple model of optimal intertemporal consumption. In this endeavor we draw on the natural science literature on aging. According to the purposed theory, the speed of the aging process and the time of death are endogenously determined by optimal...... health investments. At the same time, physiological aspects of the aging process influence optimal savings and health investment. We calibrate the model for the average US male in 2000 and proceed to show that the calibrated model accounts well for the cross-country link between labor productivity...

  20. Environmental value and valuation over time

    OpenAIRE

    Gabriela Scheufele; Jeff Bennett

    2008-01-01

    Time and value are related concepts that influence human behaviour. Although classical topics in human thinking throughout the ages, few environmental economic non-market valuation studies have attempted to link the two concepts. Economists have estimated non-market environmental values in monetary terms for over 30 years. This history of valuation provides an opportunity to compare value estimates and how valuation techniques have changed over time. This research aims to compare value estima...

  1. Mitochondria and the aging heart

    Institute of Scientific and Technical Information of China (English)

    Ketul R Chaudhary; Haitham El-Sikhry; John M Seubert

    2011-01-01

    The average human life span has markedly increased in modern society largely attributed to advances in medical and therapeutic sciences that have successfully reduced important health risks.However,advanced age results in numerous alterations to cellular and subcellular components that can impact the overall health and function of an individual.Not surprisingly,advanced age is a major risk factor for the development of heart disease in which elderly populations observe increased morbidity and mortality.Even healthy individuals that appear to have normal heart fimction under resting conditions,actually have an increased susceptibility and vulnerability to stress.This is confounded by the impact that stress and disease can have over time to both the heart and vessels. Although, there is a rapidly growing body of literature investigating the effects of aging on the heart and how age-related alterations affect cardiac fimction, the biology of aging and underlying mechanisms remain unclear .In this review,we summarize effects of aging on the heart and discuss potential theories of cellular aging with special emphasis on mitochondrial dysfunction.

  2. Influence of sex on outcomes after percutaneous coronary intervention in patients over 75 years of age with coronary heart disease

    Directory of Open Access Journals (Sweden)

    Liu Y

    2014-10-01

    Full Text Available Yuqi Liu,* Xin Hu,* Qiao Xue, Yusheng Zhao, Yu Wang, Lei Gao Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People’s Republic of China *These authors contributed equally to this work Background: This study aimed to investigate whether there were sex differences in in-hospital and long-term outcomes for elderly patients over 75 years of age undergoing percutaneous coronary intervention for coronary heart disease.Methods: Consecutive patients aged ≥75 years who underwent percutaneous coronary intervention at a single center in the People’s Republic of China from January 2005 to December 2010 were included in this cohort study. Clinical characteristics and in-hospital and long-term outcomes were compared between men and women.Results: A total of 465 patients (34.8% women, mean age 78.5±3.2 years were recruited. Men had a higher prevalence of ST elevation myocardial infarction but were less likely to have heart failure than women (P<0.05. Similar rates of successful in-hospital procedures and deaths were observed in men and women. After a mean follow-up of 3 years, no significant differences were observed between men and women in mortality (12.5% versus 8.0%, P=0.151, myocardial infarction (1.4% versus 2.7%, P=0.368, target vessel revascularization (6.1% versus 4.7%, P=0.540, or cerebral vascular disease (7.9% versus 6.0%, P=0.472. Cox proportional hazards analysis revealed that sex was not independently associated with either in-hospital mortality or long-term mortality.Conclusion: In elderly patients over 75 years of age, sex influences the prognosis after percutaneous coronary intervention for coronary heart disease. Keywords: percutaneous coronary intervention, elderly, sex

  3. Aging and skilled problem solving.

    Science.gov (United States)

    Charness, N

    1981-03-01

    Information-processing models of problem solving too often are based on restrictive age ranges. On the other hand, gerontologists have investigated few problem-solving tasks and have rarely generated explicit models. As this article demonstrates, both fields can benefit by closer collaboration. One major issue in gerontology is whether aging is associated with irreversible decrement or developmental plasticity. If both processes occur, then an appropriate strategy for investigating aging is to equate age groups for molar problem-solving performance and search for differences in the underlying components. This strategy was adopted to examine the relation of age and skill to problem solving in chess. Chess players were selected to vary widely in age and skill such that these variables were uncorrelated. Problem-solving and memory tasks were administered. Skill level was the only significant predictor for accuracy in both a choose-a-move task and a speeded end-game evaluation task. Age (negatively) and skill (positively) jointly determined performance in an unexpected recall task. Efficient chunking in recall was positively related to skill, though negatively related to age. Recognition confidence, though not accuracy, was negatively related to age. Thus despite age-related declines in encoding and retrieval of information, older players match the problem-solving performance of equivalently skilled younger players. Apparently, they can search the problem space more efficiently, as evidenced by taking less time to select an equally good move. Models of chess skill that stress that role of encoding efficiency, as indexed by chunking in recall, need to be modified to account for performance over the life span.

  4. [Normal aging and cognition].

    Science.gov (United States)

    Ska, Bernadette; Joanette, Yves

    2006-03-01

    It is now well documented that normal aging modifies the cognitive functioning and most observations suggest that cognition evolves in the direction of deterioration. The more frequently impaired functions are memory, attention and visual-spatial abilities. On the other hand, some abilities seem to increase, such as vocabulary. Considering the aging effect on cognition, questions remain regarding directionality, universality and reversibility. A great variability in aged related impacts is observed among subjects and among cognitive domains. Some individuals evolved more rapidly than others. Some cognitive functions are more affected by aging than others. General and specific factors are hypothesized to explain the aged related cognitive decline. Among them, educational level, health, cognitive style, life style, personality, are likely to modulate the aged related cognitive evolution by influencing attentional resources and cerebral plasticity. Cognitive resources are essential to develop adaptative strategies. During the life span, resources are activated and increased by learning and training. Considering the role of cognitive resources, successful aging is dependent on several conditions : absence of disease leading to a loss of autonomy, maintenance of cognitive and physical activities, and active and social engaged lifestyle. PMID:16527210

  5. Envy, politics, and age.

    Science.gov (United States)

    Harris, Christine R; Henniger, Nicole E

    2013-01-01

    In the last 5 years, the phrase "politics of envy" has appeared more than 621 times in English-language newspapers, generally in opinion essays contending that political liberalism reflects and exploits feelings of envy. Oddly, this assertion has not been tested empirically. We did so with a large adult sample (n = 357). Participants completed a Dispositional Envy Scale and questions about political ideology, socioeconomic status, and age. Envy and age were moderately correlated; younger people reported greater envy. Political ideology and envy were weakly correlated; however, this relationship was not significant when controlling for age. PMID:23471177

  6. An 80 Mbytes/s data transfer and processing system

    International Nuclear Information System (INIS)

    We describe hardware and software aspects of a very fast and versatile, yet conceptually simple, data transfer and processing system for use with future accelerators. It consists of a transputer-based crate controller (CC), which includes an Intel i860 microcomputer, and of a set of readout cards (RC), each containing a digital signal processor (DSP) for fast data parametrisation and compaction. The reduced data is written into a dual port memory (DPM), where it can be accessed concurrently by the transputer and transferred to a common DPM on the CC card. A crateful of data thus assembled at one place can further be processed by the powerful i860 microcomputer. Address generators (simple binary counters) are included on the crate controller and each readout card to enable direct memory access (DMA) operations, resulting in a considerable increase in data transfer speed (maximum 80 Mbytes/s). The use of a transputer as the sole controller processor, in conjunction with DPMs, renders bus arbitration unnecessary leading to very simple interfacing logic and operating software. The four high speed serial links of the transputer greatly facilitate downloading of programs and intercrate communications. An Intel i960CA processor, situated on the CC card, is used for fast data transfer between crates by means of its 32-bit wide DMA channel. The operating software is written in the Occam language, which was specially developed for programming concurrent systems based on transputers. (author)

  7. Stress, Inflammation and Aging

    OpenAIRE

    Lavretsky, Helen; Newhouse, Paul A.

    2012-01-01

    This editorial provides a summary of the state of research on stress-related changes associated with aging and discuss how factors such as inflammation and sex steroid alterations may interact with psychosocial stress to affect the risk for mood and cognitive disturbance in older individuals. The authors provide an integrated summary of four studies reported in this issue of the journal and views on future direction in stress and aging research and interventions targeting resilience to stress.

  8. Protein oxidation and ageing

    DEFF Research Database (Denmark)

    Linton, S; Davies, Michael Jonathan; Dean, R T

    2001-01-01

    of redox-active metal ions that could catalyse oxidant formation. As a result of this decrease in antioxidant defences, and increased rate of ROS formation, it is possible that the impact of ROS increases with age. ROS are known to oxidise biological macromolecules, with proteins an important target....... If the argument that the impact of ROS increases with age is true, then proteins would be expected to accumulate oxidised materials with age, and the rate of such accumulation should increase with time, reflecting impaired inefficiency of homeostasis. Here we review the evidence for the accumulation of oxidised......, or modified, extra- and intra-cellular proteins in vivo....

  9. Growth hormone and aging

    OpenAIRE

    Bartke, Andrzej; Brown-Borg, Holly; Kinney, Beth; Mattison, Julie; Wright, Chris; Hauck, Steven; Coschigano, Karen; Kopchick, John

    2000-01-01

    The potential usefulness of growth hormone (GH) as an anti-aging therapy is of considerable current interest. Secretion of GH normally declines during aging and administration of GH can reverse age-related changes in body composition. However, mutant dwarf mice with congenital GH deficiency and GH resistant GH-R-KO mice live much longer than their normal siblings, while a pathological elevation of GH levels reduces life expectancy in both mice and men. We propose that the actions of GH on gro...

  10. Sleep and Aging

    Science.gov (United States)

    ... version of this page please turn Javascript on. Sleep and Aging About Sleep We all look forward to a good night's ... health and quality of life. Two Types of Sleep There are two types of sleep: non-rapid ...

  11. Sleep and Aging: Insomnia

    Science.gov (United States)

    ... page please turn Javascript on. Sleep and Aging Insomnia Insomnia is the most common sleep complaint at ... at greater risk for falling. Health Issues and Insomnia Disorders that cause pain or discomfort during the ...

  12. Aging Men and Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Thompson B

    2015-01-01

    Full Text Available Prostate cancer (PCa is one of the most commonly diagnosed cancers in men worldwide and its incidence increases with age, mainly affecting elderly men aged 60 and above. Factors known to be associated with the development and progression of PCa are age, family history, and race/ethnicity, with age being the most important factor. The reasons for the increased incidence and mortality due to prostate cancer in elderly men are not entirely clear. Continued exposure to environmental and dietary factors may lead to accumulation of genetic and epigenetic changes over the life-span, leading to altered expression and/or activity of tumor promoter and tumor suppressor genes. Changing levels of endogenous hormones (like androgens and metabolism in elderly men may also play a role in the development of prostate cancers which may be further influenced by testosterone replacement therapy. For many decades now preventative strategies and treatments such as radiation therapy or hormone therapy, and others have been administered to manage PCa; however current studies and evidence suggest that PCa is undertreated in elderly men, despite evidence of efficacy of these treatments, which leads to higher prevalence of mortality in this age group. Studies involving basic research, preventative and management strategies are still underway to understand the mechanisms of PCa development in elderly men and treatment of this disease in ageing male population.

  13. Population aging and legal retirement age

    OpenAIRE

    Lacomba, Juan Antonio; Lagos, Francisco Miguel

    2005-01-01

    This paper analyzes the effects of population aging on the preferred legal retirement age. What is revealed is the crucial role that the indirect ???macro??? effects resulting from a change in the legal retirement age play in the optimal decision. Two Social Security systems are studied. Under a defined contribution scheme aging lowers the preferred legal retirement age. However, under a defined pension scheme the retirement age is delayed. This result shows the relevance of correctly c...

  14. Aging and Circadian Rhythms.

    Science.gov (United States)

    Duffy, Jeanne F; Zitting, Kirsi-Marja; Chinoy, Evan D

    2015-12-01

    Aging is associated with numerous changes, including changes in sleep timing, duration, and quality. The circadian timing system interacts with a sleep-wake homeostatic system to regulate human sleep, including sleep timing and structure. This article reviews key features of the human circadian timing system, age-related changes in the circadian timing system, and how those changes may contribute to the observed alterations in sleep. PMID:26568120

  15. Exercise, Inflammation and Aging

    OpenAIRE

    Jeffrey A Woods; Wilund, Kenneth R.; Martin, Stephen A.; Kistler, Brandon M.

    2011-01-01

    Aging results in chronic low grade inflammation that is associated with increased risk for disease, poor physical functioning and mortality. Strategies that reduce age-related inflammation may improve the quality of life in older adults. Regular exercise is recommended for older people for a variety of reasons including increasing muscle mass and reducing risk for chronic diseases of the heart and metabolic systems. Only recently has exercise been examined in the context of inflammation. This...

  16. Synchronising EDML and NorthGRIP ice cores using d18O of atmospheric oxygen (d18 Oatm) and CH4 measurements over MIS5 (80-123 kyr)

    DEFF Research Database (Denmark)

    Capron, E; Landais, A; Lemieux-Dudon, B;

    2010-01-01

    of interest, CH4 records alone are not sufficient to construct a common gas timescale between the two cores. Millennial-scale variations of delta O-18(atm) are evidenced over MIS 5 both on the Antarctic and Greenland ice cores and are coupled to CH4 profiles to synchronise the NorthGRIP and EDML records...

  17. Evolution and Ageing

    OpenAIRE

    de Oliveira, S. Moss; Alves, Domingos; Martins, J. S. Sa

    2000-01-01

    The idea of this review is to connect the different models of evolution to those of biological ageing through Darwin's theory. We start with the Eigen model of quasispecies for microevolution, then introduce the Bak-Sneppen model for macroevolution and, finally, present the Penna model for biological ageing and some of its most important results. We also explore the concept of coevolution using this model.

  18. Envelhecimento e letramento: a leitura e a escrita na perspectiva de pessoas com mais de 60 anos de idade Aging and literacy: reading and writing from the perspective of people over 60

    Directory of Open Access Journals (Sweden)

    Rebecca Torquato

    2011-01-01

    Full Text Available Este artigo objetiva verificar os papéis que práticas de letramento assumem para pessoas com mais de 60 anos. A pesquisa foi realizada de um ponto de vista qualitativo/quantitativo, a partir da aplicação de um questionário junto a 40 sujeitos com idade superior a 60 anos. Foram coletadas informações sobre as práticas de leitura e de escrita, as suas dificuldades, bem como a relevância dessas práticas no próprio processo de envelhecimento. Verificou-se que os idosos referem dificuldades relacionadas a questões ortográficas, textuais e biológicas. As atividades de letramento são utilizadas, também, com o objetivo de melhorar a cognição. Além disso, eles reconhecem que essas atividades trazem benefícios para a promoção de um envelhecimento ativo e saudável.This paper aims at examining the roles played by literacy classes for adults older than 60. Forty individuals over 60 years old were interviewed for this quantitative/qualitative study. Information was gathered on their experiences with reading and writing, their difficulties and the perceived relevance of those classes on the ageing process. The participants indicated having difficulties with orthographic, textual and biological questions. The literacy activities were also used to improve their cognitive abilities. Moreover, the participants identified benefits of those activities for a healthy and active ageing.

  19. Heart failure in very elderly population- a profile of heart failure in patients over the age of eighty

    Institute of Scientific and Technical Information of China (English)

    Christopher V.Chien; Dani Hackner; Ernst R. Schwarz

    2007-01-01

    Objective Heart failure is an epidemic in the elderly, but there is a striking lack of data in this clinically important patient population. We investigated the demographics, cardiac performance, and medication management of a segment of the hospital population in at least their eighth decade of life. Methods We retrospectively reviewed 75 records of heart failure patients who were 80 years of age or older. Records were reviewed for demographic information, presence or absence of diastolic dysfunction, evaluation of ejection fraction, and medication usage including angiotensin-concerting enzyme (ACE) inhibitors, angiotensin receptor antagonists (ARBs),beta-adrenergic blockers, digoxin, and aldosterone antagonists. Assessment for contra-indications to ACE inhibitor or ARBs use was also performed to assess co-morbidities that limit treatment of heart failure. Results The population of very elderly with heart failure is heterogeneous. We found a higher proportion of females as well as higher rates of diastolic dysfunction in patients aged ≥ 90 years compared to patients between the ages of 80-89 years. Usage of ACE inhibitors, ARBs and beta-adrenergic blockers was strikingly low throughout the very elderly population. While co-morbid conditions limited use of agents in many cases, there was a lack of explicit contra-indication in most patients not on an ACE inhibitor or an ARB. Conclusions Heart failure is not a single disease processes, but a continuum of disease processes that vary with age. The elderly with heart failure are an undertreated population, in part due to the multitude of co-morbidities that affect them. Further prospective studies are needed to better understand the physiology and ideal treatment regiment in this growing population.

  20. Aging, frailty and age-related diseases.

    Science.gov (United States)

    Fulop, T; Larbi, A; Witkowski, J M; McElhaney, J; Loeb, M; Mitnitski, A; Pawelec, G

    2010-10-01

    The concept of frailty as a medically distinct syndrome has evolved based on the clinical experience of geriatricians and is clinically well recognizable. Frailty is a nonspecific state of vulnerability, which reflects multisystem physiological change. These changes underlying frailty do not always achieve disease status, so some people, usually very elderly, are frail without a specific life threatening illness. Current thinking is that not only physical but also psychological, cognitive and social factors contribute to this syndrome and need to be taken into account in its definition and treatment. Together, these signs and symptoms seem to reflect a reduced functional reserve and consequent decrease in adaptation (resilience) to any sort of stressor and perhaps even in the absence of extrinsic stressors. The overall consequence is that frail elderly are at higher risk for accelerated physical and cognitive decline, disability and death. All these characteristics associated with frailty can easily be applied to the definition and characterization of the aging process per se and there is little consensus in the literature concerning the physiological/biological pathways associated with or determining frailty. It is probably true to say that a consensus view would implicate heightened chronic systemic inflammation as a major contributor to frailty. This review will focus on the relationship between aging, frailty and age-related diseases, and will highlight possible interventions to reduce the occurrence and effects of frailty in elderly people. PMID:20559726

  1. The Differentiated Effectiveness of a Printed versus a Web-Based Tailored Physical Activity Intervention among Adults Aged over 50

    Science.gov (United States)

    Peels, D. A.; van Stralen, M. M.; Bolman, C.; Golsteijn, R. H. J.; de Vries, H.; Mudde, A. N.; Lechner, L.

    2014-01-01

    This study provides insight in the effectiveness of a print-delivered and a Web-based physical activity (PA) intervention (with or without additional environmental information on local PA possibilities) among people aged over 50. Intervention groups (print-delivered basic [PB; n = 439], print-delivered environmental [PE; n = 435], Web-based basic…

  2. The Ankle Injury Management (AIM) trial: a pragmatic, multicentre, equivalence randomised controlled trial and economic evaluation comparing close contact casting with open surgical reduction and internal fixation in the treatment of unstable ankle fractures in patients aged over 60 years.

    Science.gov (United States)

    Keene, David J; Mistry, Dipesh; Nam, Julian; Tutton, Elizabeth; Handley, Robert; Morgan, Lesley; Roberts, Emma; Gray, Bridget; Briggs, Andrew; Lall, Ranjit; Chesser, Tim Js; Pallister, Ian; Lamb, Sarah E; Willett, Keith

    2016-01-01

    BACKGROUND Close contact casting (CCC) may offer an alternative to open reduction and internal fixation (ORIF) surgery for unstable ankle fractures in older adults. OBJECTIVES We aimed to (1) determine if CCC for unstable ankle fractures in adults aged over 60 years resulted in equivalent clinical outcome compared with ORIF, (2) estimate cost-effectiveness to the NHS and society and (3) explore participant experiences. DESIGN A pragmatic, multicentre, equivalence randomised controlled trial incorporating health economic evaluation and qualitative study. SETTING Trauma and orthopaedic departments of 24 NHS hospitals. PARTICIPANTS Adults aged over 60 years with unstable ankle fracture. Those with serious limb or concomitant disease or substantial cognitive impairment were excluded. INTERVENTIONS CCC was conducted under anaesthetic in theatre by surgeons who attended training. ORIF was as per local practice. Participants were randomised in 1 : 1 allocation via remote telephone randomisation. Sequence generation was by random block size, with stratification by centre and fracture pattern. MAIN OUTCOME MEASURES Follow-up was conducted at 6 weeks and, by blinded outcome assessors, at 6 months after randomisation. The primary outcome was the Olerud-Molander Ankle Score (OMAS), a patient-reported assessment of ankle function, at 6 months. Secondary outcomes were quality of life (as measured by the European Quality of Life 5-Dimensions, Short Form questionnaire-12 items), pain, ankle range of motion and mobility (as measured by the timed up and go test), patient satisfaction and radiological measures. In accordance with equivalence trial US Food and Drug Administration guidance, primary analysis was per protocol. RESULTS We recruited 620 participants, 95 from the pilot and 525 from the multicentre phase, between June 2010 and November 2013. The majority of participants, 579 out of 620 (93%), received the allocated treatment; 52 out of 275 (19%) who received CCC later

  3. Nutrients, Microglia Aging, and Brain Aging

    OpenAIRE

    Zhou Wu; Janchun Yu; Aiqin Zhu; Hiroshi Nakanishi

    2016-01-01

    As the life expectancy continues to increase, the cognitive decline associated with Alzheimer’s disease (AD) becomes a big major issue in the world. After cellular activation upon systemic inflammation, microglia, the resident immune cells in the brain, start to release proinflammatory mediators to trigger neuroinflammation. We have found that chronic systemic inflammatory challenges induce differential age-dependent microglial responses, which are in line with the impairment of learning and ...

  4. Nutrition and sarcopenia of ageing

    OpenAIRE

    Fujita, Satoshi; Volpi, Elena

    2004-01-01

    Sarcopenia, the loss of muscle mass and function with ageing, is a multifactorial condition that slowly develops over decades and becomes a significant contributor to disability in the older population. Malnutrition and alterations in the muscle anabolic response to nutritional stimuli have been identified as potentially preventable factors that may significantly contribute to sarcopenia. In the present article we review the most recent findings regarding the role of nutritional factors in th...

  5. Modulating aging and longevity

    DEFF Research Database (Denmark)

    Rattan, Suresh

    Provides information and an evaluation of a variety of approaches tried for modulating aging and longevity, including dietary supplementation with antioxidants, vitamins and hormones, genetic engineering, life-style alterations, and hormesis through mild stress. After decades of systematic....... This book provides the most up-to-date information and a critical evaluation of a variety of approaches being tried for modulating aging and longevity, including dietary supplementation with antioxidants, vitamins and hormones, genetic engineering, life-style alterations, and hormesis through mild stress...

  6. Expression and Identification of Inclusion Forming-related Domain of NS80 Nonstructural Protein of Grass Carp Reovirus

    Institute of Scientific and Technical Information of China (English)

    Chao FAN; Lan-lan ZHANG; Cheng-feng LEI; Qin FANG

    2009-01-01

    Grass carp reovirus (GCRV), a double stranded RNA virus that infects aquatic animals, often with disastrous effects, belongs to the genus Aquareovirus and family Reoviridea. Similar to other reoviruses, genome replication of GCRV in infected cells occurs in cytoplasmic inclusion bodies, also called viral factories. Sequences analysis revealed the nonstructural protein NS80, encoded by GCRV segment 4, has a high similarity with uNS in MRV(Mammalian orthoreoviruses), which may be associated with viral factory formation. To understand the function of the uNS80 protein in virus replication, the initial expression and identification of the immunogenicity of the GCRV NS80 protein inclusion forming-related region (335.742) was investigated in this study. It is shown that the over-expressed fusion protein was produced by inducing with IPTG at 28oC. In addition, serum specific rabbit antibody was obtained by using super purified recombinant NS80(335.742) protein as antigen. Moreover, the expressed protein was able to bind to anti-his-tag monoclonal antibody (mouse) and NS80(335-742) specific rabbit antibody. Further western blot analysis indicates that the antiserum could detect NS80 or NS80C protein expression in GCRV infected cells. This data provides a foundation for further investigation of the role of NS80 in viral inclusion formation and virion assembly.

  7. Religion and aging.

    Science.gov (United States)

    Margaret Hall, C

    1985-03-01

    Life history data and cultural values are used to suggest ways in which personal and social beliefs influence the quality of experiences of aging. Central questions are the extent to which an individual can select beliefs that lead to a longer, more meaningful life and the special influence that religion may have in enhancing aging. Responsiveness to needs of the elderly is a necessary component of enlightened planning for the future. Secularization and industrialization have diminished roles and expectations for the elderly. Religion may be an effective means to identify these concerns and improve the quality of life of older people. PMID:24307195

  8. Characterization of Ku-deficient cells derived from Ku70-/- and Ku80-/- mice

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    @@ To determine the physiological roles of Ku70 and Ku80, we generated Ku70-/- and Ku80-/- knockout mice via targeted gene disruption (Nussenzweig et al. Nature 382, 1996; Ouyang et al. J Exp Med 186, 1997).

  9. Design of an age hardening Mg-Li alloy and its aging behavior

    Institute of Scientific and Technical Information of China (English)

    Hao Zhong; Peiying Liu; Tietao Zhou; Huanxi Li

    2005-01-01

    An effort was made to design an age hardening Mg-Li alloy based on the phase diagrams calculated by means of "THERMO-CALC"-a thermodynamic software. Experiments were carried out to verify the calculated results by melting the alloy and examining its structure and aging behavior. The results show that the alloy possesses a structure constituent as expected, besides,the alloy has apparent aging behavior and over aging happens even at lower temperature. Metastable (Mg, Li, Al, Zn) phase has been identified when the hardness reaches the aging peak. With the increase of the aging time, (Mg, Li, Al, Zn) phase transforms to stable α phase and over aging happens.

  10. Cancer and aging

    DEFF Research Database (Denmark)

    Pedersen, Jacob K; Engholm, Gerda; Skytthe, Axel;

    2016-01-01

    Epidemiological cancer data shed light on key questions within basic science, clinical medicine and public health. For decades, Denmark has had linkable health registers that contain individual level data on the entire population with virtually complete follow-up. This has enabled high quality...... studies of cancer epidemiology and minimized the challenges often faced in many countries, such as uncertain identification of the study base, age misreporting, and low validity of the cancer diagnoses. However, methodological challenges still remain to be addressed, especially in cancer epidemiology...... studies among the elderly and the oldest-old. For example, a characteristic pattern for many cancer types is that the incidence increases up to a maximum at about ages 75-90 years and is then followed by a decline or a leveling off at the oldest ages. It has been suggested that the oldest individuals may...

  11. 老年人躯体机能受损现状及其影响因素分析%Study on the declining physical functions and its influencing factors among the Chinese elderly aged 65 years and over

    Institute of Scientific and Technical Information of China (English)

    王德文

    2008-01-01

    目的 了解老年人躯体性日常生活能力(PADL)以及工具性日常生活能力(IADL)的受损现况及其影响因素.方法 利用中国老年健康长寿跟踪调查数据,对其中2002年PADL和IADL完全自理的6761人和3556人进行跟踪分析.结果 2002年1ADL(或PADL)完全自理的老年人到2005年时保持IADL(或PADL)完全自理的男女比例分别为59.3%和51.8%(或87.1%和81.5%).65~74、75~84、85~94以及95~105岁组的老年人,从2002年IADL或PADL完全自理到2005年时分别只有70.0%、47.0%、24.0%和15.0%保持IADL完全自理,约有95.0%、87.0%、74.0%和55.0%保持PADL完全自理.在控制性别、社会经济等变量后,老年人年龄越大、过去2年内患重大疾病的次数越多以及认知能力越低其IADL或PADL受损的可能性越大.结论 老年人躯体机能受损程度随着年龄增大加重.IADL受损程度严重于PADL.老年女性受损程度均比男性严重;老年人的年龄、过去2年内息重大疾病的次数以及认知能力对其躯体机能受损具有预测性作用.%Objective To understand the declining pattern of physical activities on daily living (PADL) and instrumental activities of daily living (IADL) and its influencing factors among the Chinese elderly aged 65 years and over. Methods Using data from 2002 and 2005 of the Chinese Longitudinal Health Longevity Study (CLHLS), 6761 Chinese elderly with fully independent PADL in 2002 and 3556 Chinese elderly with fully independent IADL in 2002 were studied. Results Data showed that the male elderly with fully dependent IADL at baseline in 2002 declined to 59.3% but kept the IADL in full independent in 2005, while that of female elderly were 51.8 % still keeping the IADL full independent in2005. Male elderly who at baseline with the PADL fully dependent in 2002 declined to 87.1% but kept the PADL full independent in 2005, while that of female elderly were 81.5% keeping the PADL full independent in 2005.There were only 70

  12. Genome instability and aging.

    Science.gov (United States)

    Vijg, Jan; Suh, Yousin

    2013-01-01

    Genome instability has long been implicated as the main causal factor in aging. Somatic cells are continuously exposed to various sources of DNA damage, from reactive oxygen species to UV radiation to environmental mutagens. To cope with the tens of thousands of chemical lesions introduced into the genome of a typical cell each day, a complex network of genome maintenance systems acts to remove damage and restore the correct base pair sequence. Occasionally, however, repair is erroneous, and such errors, as well as the occasional failure to correctly replicate the genome during cell division, are the basis for mutations and epimutations. There is now ample evidence that mutations accumulate in various organs and tissues of higher animals, including humans, mice, and flies. What is not known, however, is whether the frequency of these random changes is sufficient to cause the phenotypic effects generally associated with aging. The exception is cancer, an age-related disease caused by the accumulation of mutations and epimutations. Here, we first review current concepts regarding the relationship between DNA damage, repair, and mutation, as well as the data regarding genome alterations as a function of age. We then describe a model for how randomly induced DNA sequence and epigenomic variants in the somatic genomes of animals can result in functional decline and disease in old age. Finally, we discuss the genetics of genome instability in relation to longevity to address the importance of alterations in the somatic genome as a causal factor in aging and to underscore the opportunities provided by genetic approaches to develop interventions that attenuate genome instability, reduce disease risk, and increase life span. PMID:23398157

  13. Estrogens and aging skin

    OpenAIRE

    Thornton, M. Julie

    2013-01-01

    Estrogen deficiency following menopause results in atrophic skin changes and acceleration of skin aging. Estrogens significantly modulate skin physiology, targeting keratinocytes, fibroblasts, melanocytes, hair follicles and sebaceous glands, and improve angiogenesis, wound healing and immune responses. Estrogen insufficiency decreases defense against oxidative stress; skin becomes thinner with less collagen, decreased elasticity, increased wrinkling, increased dryness and reduced vascularity...

  14. Bioethics and aging

    Directory of Open Access Journals (Sweden)

    Domingo Castillo

    2012-05-01

    Full Text Available The purpose of this presentation is to discuss some concepts related to bioethics and ageing, specifically with regard to health and disease. Considerations on medical practice are made by referring to Kant and Heidelberg school of thought. Perception of time in the elderly and issues such as euthanasia and death are mentioned.

  15. GALVANIC CORROSION AND INHIBITOR SELECTION BETWEEN 13Cr-L-80 STEEL AND N-80 STEEL%13Cr-L-80钢和N-80钢的电偶腐蚀及缓蚀剂研究

    Institute of Scientific and Technical Information of China (English)

    舒福昌

    2007-01-01

    针对文昌13-1/2油田套管设计中采用的13Cr-L-80 和N-80两种钢材偶接的情况,采用挂片失重法研究了两种金属在弱酸性完井液中的电偶腐蚀,筛选了抑制该电偶腐蚀的缓蚀剂,并对其缓蚀性能进行了评价.结果表明,在60 ℃下弱酸性完井液中两种材料偶接时,13Cr-L-80钢腐蚀速度下降,N-80钢的腐蚀速度上升,产生了明显的电偶腐蚀效应.从9种缓蚀剂中筛选出JC-6,在加量1.5%时,13Cr-L-80和N-80偶接、60 ℃时腐蚀速度分别降至0. 012和0.165 mm/a;质量比为9∶1的JC-6与PA复配物(代号JCP-6)使偶接钢材腐蚀速度进一步降低,在加量1.5%时,70 ℃时的腐蚀速度分别降至0.013和0.069 mm/a.

  16. Age and Value Orientations

    Directory of Open Access Journals (Sweden)

    Asya Kh. Kukubayeva

    2013-01-01

    Full Text Available The present article deals with value orientations and their role in men’s lives, particularly, in young people’s lives. This notion was introduced by the American theoretical sociologist T. Parsons, one of the creators of modern theoretical sociology. The scientist made an attempt to construct the structural and analytical theory of social action, combining personal interests (needs and aims and situation, it takes place in. The issue of value orientations remains acute for psychology. Herein we have considered several most important works, relating to the considered issue. Age aspects of young people’s value orientations are of peculiar interest to us. When analyzing this phenomenon, one should take into consideration the psychological formations, inhere for a certain age. In fact every age has its unique structure, which may change when passing from one development stage to another. Basing on this fact, we’ve considered the values, depending on the age features of the youth, relying upon the works of the scientists, working with different categories of the youth, such as: teenagers, students, children of different nationalities. It is not surprising that most scientists have come to the conclusion that the chief role in value orientation belongs to a family, originates in relations with parents and teachers. The positive reinforcement to the future develops throughout life in accordance with a lifestyle of a family, society and political situation in a state.Life orientations as a type of value orientations show different types of young people’s preferences. Value structure of its consciousness has its own specific character, depending on the age peculiarities. The dynamics of the transition from one age to another is accompanied with the reappraisal of values, eventually, influencing the life strategy of the future generation

  17. Food Additive P-80 Impacts Mouse Gut Microbiota Promoting Intestinal Inflammation, Obesity and Liver Dysfunction

    Science.gov (United States)

    Singh, Ratnesh Kumar; Wheildon, Nolan; Ishikawa, Seiichi

    2016-01-01

    The increasing prevalence of obesity has emerged as one of the most important global public health issue. The change to the human microbiome as a result of changes in the quality and quantity of food intake over the past several decades has been implicated in the development of obesity and metabolic syndrome. We administered polysorbate-80 to mice via gavage. The researchers monitor liver noninvasively using a bioluminescence imaging. For the liver dysfunction we measure the liver enzymes and PAS stain on liver, electron microscopy liver mitochondria. For the assessment of intestinal inflammation we measured fecal LCN2, LPS, MPO and flagellin by ELISA and qPCR. We use confocal microscopy to detect closet bacteria near the epithelium. 16S sequence was used for the composition of microbiota. Compared with control mice, those receiving emulsifier, showed impaired glycemic tolerance, hyperinsulinemia, altered liver enzymes, larger mitochondria and increased gall bladder size. Additionally, mice in the experimental group showed higher levels of DCA, reduced Muc2 RNA expression, reduced mucus thickness in the intestinal epithelium and increased gut permeability. Intestinal bacteria of mice receiving P-80 were found deeper in the mucus and closer to the intestinal epithelium and had increased level of bioactive LPS, flagellin and LCN2 expression. The result of the study are supportive of evidence that emulsifier agents such as polysorbate-80, may be contributing to obesity related intestinal inflammation and progression of liver dysfunction and alternation of gut microbiota.

  18. Glucose and Aging

    Science.gov (United States)

    Ely, John T. A.

    2008-04-01

    When a human's enzymes attach glucose to proteins they do so at specific sites on a specific molecule for a specific purpose that also can include ascorbic acid (AA) at a high level such as 1 gram per hour during exposure. In an AA synthesizing animal the manifold increase of AA produced in response to illness is automatic. In contrast, the human non-enzymatic process adds glucose haphazardly to any number of sites along available peptide chains. As Cerami clarified decades ago, extensive crosslinking of proteins contributes to loss of elasticity in aging tissues. Ascorbic acid reduces the random non-enyzmatic glycation of proteins. Moreover, AA is a cofactor for hydroxylase enzymes that are necessary for the production and replacement of collagen and other structural proteins. We will discuss the relevance of ``aging is scurvy'' to the biochemistry of human aging.

  19. Charge Accumulation in LDPE and XLPE Conditioned at 80oC under Reduced Pressure

    DEFF Research Database (Denmark)

    Fleming, Robert J.; Henriksen, Mogens; Holbøll, Joachim T.

    1997-01-01

    were then cooled to room temperature over a period of at least 6hr, still under rotary pump pressure and in short circuit, while others were cooled to room temperature in less than 1.5hr in the laboratory air. DC fields of 18kV/mm were then applied at room temperature, and space charge accumulation......The effects of thermal conditioning, under reduced pressure, on space accumulation in planar LDPE and XLPE samples under DC stress, have been investigated. The samples were conditioned prior to voltage application by being held at 80oC for 2-3 days in short circuit at rotary pump pressure. Some...

  20. 40 CFR 80.210 - What sulfur standards apply to gasoline downstream from refineries and importers?

    Science.gov (United States)

    2010-07-01

    ... gasoline downstream from refineries and importers? 80.210 Section 80.210 Protection of Environment... Gasoline Sulfur Gasoline Sulfur Standards § 80.210 What sulfur standards apply to gasoline downstream from... downstream from refineries and import facilities, including gasoline at facilities of distributors,...

  1. Olfaction and Aging: A Mini-Review.

    Science.gov (United States)

    Attems, Johannes; Walker, Lauren; Jellinger, Kurt A

    2015-01-01

    Decreased olfactory function is very common in the older population, being present in >50% of individuals aged between 65 and 80 years and in 62-80% of those >80 years of age. Smell dysfunction significantly influences physical well-being, quality of life, nutritional status as well as everyday safety and is associated with increased mortality. Multiple factors contribute to age-related olfactory sensory loss, including nasal engorgement, cumulative damage of the olfactory epithelium from environmental insults, a reduction in mucosal metabolizing enzymes, sensory loss of receptor cells to odorants, and changes in neurotransmitter and neuromodulator systems. In addition, structural and functional abnormalities of the olfactory epithelium, olfactory bulb, central olfactory cortex, and basic olfactory circuitry, which are related to the neuronal expression of aberrant proteins in these areas, may result in olfactory sensory impairment in aging and neurodegenerative diseases. Impaired odour identification is associated with a decrease in cognitive abilities and memory decline. A reduction in the sense of smell is considered to potentially represent an early and important warning of neurodegenerative disorders, particularly of Parkinson's disease and Alzheimer's disease, and, in mild cognitive impairment, olfactory impairment may herald progression to dementia. Further investigations of the potential role of olfactory dysfunction in the early diagnosis and treatment of neurodegenerative diseases are warranted.

  2. CETA and the Aging.

    Science.gov (United States)

    Schram, Sanford F.; Osten, David F.

    1978-01-01

    To assess the impact of the 1973 Comprehensive Employment and Training Act (CETA) on older worker's problems, article examines CETA's history, options, and authority. Finds major systemic factors that encourage local prime sponsors to understate aging populations' needs. Concludes there is a need for substantial CETA changes to effectively serve…

  3. Curcumin and aging

    Science.gov (United States)

    Curcumin has been used commonly as a spice, food additive, and an herbal medicine worldwide. Known as a bioactive polyphenolic, curcumin has a broad range of beneficial properties to human health. Recently, active research on curcumin with respect to aging and related traits in model organisms has d...

  4. [Ageing society and laboratory medicine].

    Science.gov (United States)

    Okabe, H

    2000-09-01

    pseudocholin esterase and albumin, especially mercaptoalbumin were observed in the healthy aged with advancing age. The early diagnosis and prediction of prognosis for the latent ailments in the aged was stressed. As to the study of variations of serum protein levels in the healthy aged, variations of serum proteins were classified into three types, 1) mainly acute phase reactant proteins such as alpha 1AT increased with advancing age, 2) transporting proteins such an albumin decreased and 3) proteins with no significant variation these were useful proteins for the early finding of latent ailments. The higher increase of alpha 1AT/beta 2III in the healthy aged over 60 y.o. was suspected to become severe in near future. PMID:11051792

  5. HIV after 40 in rural South Africa: A life course approach to HIV vulnerability among middle aged and older adults.

    Science.gov (United States)

    Mojola, Sanyu A; Williams, Jill; Angotti, Nicole; Gómez-Olivé, F Xavier

    2015-10-01

    South Africa has the highest number of people living with HIV in the world (over 6 million) as well as a rapidly aging population, with 15% of the population aged 50 and over. High HIV prevalence in rural former apartheid homeland areas suggests substantial aging with HIV and acquisition of HIV at older ages. We develop a life course approach to HIV vulnerability, highlighting the rise and fall of risk and protection as people age, as well as the role of contextual density in shaping HIV vulnerability. Using this approach, we draw on an innovative multi-method data set collected within the Agincourt Health and Demographic Surveillance System in South Africa, combining survey data with 60 nested life history interviews and 9 community focus group interviews. We examine HIV risk and protective factors among adults aged 40-80, as well as how and why these factors vary among people at older ages.

  6. The effect of aging on the specialized conducting system: a telemetry ECG study in rats over a 6 month period.

    Science.gov (United States)

    Rossi, Stefano; Fortunati, Ilaria; Carnevali, Luca; Baruffi, Silvana; Mastorci, Francesca; Trombini, Mimosa; Sgoifo, Andrea; Corradi, Domenico; Callegari, Sergio; Miragoli, Michele; Macchi, Emilio

    2014-01-01

    Advanced age alone appears to be a risk factor for increased susceptibility to cardiac arrhythmias. We previously observed in the aged rat heart that sinus rhythm ventricular activation is delayed and characterized by abnormal epicardial patterns although conduction velocity is normal. While these findings relate to an advanced stage of aging, it is not yet known when and how ventricular electrical impairment originates and which is the underlying substrate. To address these points, we performed continuous telemetry ECG recordings in freely moving rats over a six-month period to monitor ECG waveform changes, heart rate variability and the incidence of cardiac arrhythmias. At the end of the study, we performed in-vivo multiple lead epicardial recordings and histopathology of cardiac tissue. We found that the duration of ECG waves and intervals gradually increased and heart rate variability gradually decreased with age. Moreover, the incidence of cardiac arrhythmias gradually increased, with atrial arrhythmias exceeding ventricular arrhythmias. Epicardial multiple lead recordings confirmed abnormalities in ventricular activation patterns, likely attributable to distal conducting system dysfunctions. Microscopic analysis of aged heart specimens revealed multifocal connective tissue deposition and perinuclear myocytolysis in the atria. Our results demonstrate that aging gradually modifies the terminal part of the specialized cardiac conducting system, creating a substrate for increased arrhythmogenesis. These findings may open new therapeutic options in the management of cardiac arrhythmias in the elderly population.

  7. The effect of aging on the specialized conducting system: a telemetry ECG study in rats over a 6 month period.

    Directory of Open Access Journals (Sweden)

    Stefano Rossi

    Full Text Available Advanced age alone appears to be a risk factor for increased susceptibility to cardiac arrhythmias. We previously observed in the aged rat heart that sinus rhythm ventricular activation is delayed and characterized by abnormal epicardial patterns although conduction velocity is normal. While these findings relate to an advanced stage of aging, it is not yet known when and how ventricular electrical impairment originates and which is the underlying substrate. To address these points, we performed continuous telemetry ECG recordings in freely moving rats over a six-month period to monitor ECG waveform changes, heart rate variability and the incidence of cardiac arrhythmias. At the end of the study, we performed in-vivo multiple lead epicardial recordings and histopathology of cardiac tissue. We found that the duration of ECG waves and intervals gradually increased and heart rate variability gradually decreased with age. Moreover, the incidence of cardiac arrhythmias gradually increased, with atrial arrhythmias exceeding ventricular arrhythmias. Epicardial multiple lead recordings confirmed abnormalities in ventricular activation patterns, likely attributable to distal conducting system dysfunctions. Microscopic analysis of aged heart specimens revealed multifocal connective tissue deposition and perinuclear myocytolysis in the atria. Our results demonstrate that aging gradually modifies the terminal part of the specialized cardiac conducting system, creating a substrate for increased arrhythmogenesis. These findings may open new therapeutic options in the management of cardiac arrhythmias in the elderly population.

  8. 47 CFR 80.107 - Service of private coast stations and marine-utility stations.

    Science.gov (United States)

    2010-10-01

    ...-utility stations. 80.107 Section 80.107 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... Operating Procedures-Land Stations § 80.107 Service of private coast stations and marine-utility stations. A private coast station or a marine-utility station is authorized to transmit messages necessary for...

  9. New Approaches to the Conceptualization and Measurement of Age and Aging

    OpenAIRE

    Scherbov, S.; W.C. Sanderson

    2016-01-01

    Objectives: Most studies of population aging focus on only one characteristic of people: their chronological age. Many important characteristics of people vary with age, but agespecific characteristics also vary over time and differ from place to place. We supplement traditional measures of aging with new ones that consider the changing characteristics of people. Methods: The characteristics approach to measuring of population aging is employed. We provide examples of new measures of popu...

  10. Normal and aging hair biology and structure 'aging and hair'.

    Science.gov (United States)

    Goodier, Molly; Hordinsky, Maria

    2015-01-01

    Much like an individual's hairstyle, hair fibers along the scalp see a number of changes over the course of one's lifetime. As the decades pass, the shine and volume synonymous with youthful hair may give way to thin, dull, and brittle hair commonly associated with aging. These changes are a result of a compilation of genetic and environmental elements influencing the cells of the hair follicle, specifically the hair follicle stem cells and melanocytes. Telomere shortening, decrease in cell numbers, and particular transcription factors have all been implicated in this process. In turn, these molecular alterations lead to structural modifications of the hair fiber, decrease in melanin production, and lengthening of the telogen phase of the hair cycle. Despite this inevitable progression with aging, there exists an array of treatments such as light therapy, minoxidil, and finasteride which have been designed to mitigate the effects of aging, particularly balding and thinning hair. Although each works through a different mechanism, all aim to maintain or potentially restore the youthful quality of hair. PMID:26370639

  11. Patriarchy continues to loom large over representations of Black masculinity in the age of President Obama

    OpenAIRE

    Belle, Crystal

    2014-01-01

    While many hailed the election of the first black president with Barack Obama to be the beginning of a new “post-racial” age in the United States, the incarceration rates and racial wealth gap reveal how little has changed in the past six years. Crystal Belle examines different constructions of black masculinity in the age of President Obama. She argues that society must focus on dismantling patriarchy alongside institutional racism as both force black men to perform particularized visions of...

  12. Cognitive Impairment and Age-Related Vision Disorders: Their Possible Relationship and the Evaluation of the Use of Aspirin and Statins in a 65 Years-and-Over Sardinian Population

    Science.gov (United States)

    Mandas, Antonella; Mereu, Rosa Maria; Catte, Olga; Saba, Antonio; Serchisu, Luca; Costaggiu, Diego; Peiretti, Enrico; Caminiti, Giulia; Vinci, Michela; Casu, Maura; Piludu, Stefania; Fossarello, Maurizio; Manconi, Paolo Emilio; Dessí, Sandra

    2014-01-01

    Neurological disorders (Alzheimer’s disease, vascular and mixed dementia) and visual loss (cataract, age-related macular degeneration, glaucoma, and diabetic retinopathy) are among the most common conditions that afflict people of at least 65 years of age. An increasing body of evidence is emerging, which demonstrates that memory and vision impairment are closely, significantly, and positively linked and that statins and aspirin may lessen the risk of developing age-related visual and neurological problems. However, clinical studies have produced contradictory results. Thus, the intent of the present study was to reliably establish whether a relationship exist between various types of dementia and age-related vision disorders, and to establish whether statins and aspirin may or may not have beneficial effects on these two types of disorders. We found that participants with dementia and/or vision problems were more likely to be depressed and displayed worse functional ability in basic and instrumental activities of daily living than controls. Mini mental state examination scores were significantly lower in patients with vision disorders compared to subjects without vision disorders. A closer association with macular degeneration was found in subjects with Alzheimer’s disease than in subjects without dementia or with vascular dementia, mixed dementia, or other types of age-related vision disorders. When we considered the associations between different types of dementia and vision disorders and the use of statins and aspirin, we found a significant positive association between Alzheimer’s disease and statins on their own or in combination with aspirin, indicating that these two drugs do not appear to reduce the risk of Alzheimer’s disease or improve its clinical evolution and may, on the contrary, favor its development. No significant association in statin use alone, aspirin use alone, or the combination of these was found in subjects without vision

  13. The Expression of MGMT and Ku80 in Primary Central Nervous System Lymphoma and Prognostic Significance

    OpenAIRE

    Li, Xinwei

    2015-01-01

    The primary central nervous system lymphoma (PCSNL), as one of the uncommon extranodal lymphomas, has been recently paid more attention especially for its increasing incidence, unsatisfactory therapy and poor prognosis. MGMT is one of the most important factors determining drug resistance while Ku80 determining radiosensitivity, the expression of MGMT and Ku80 in PCNSL remains unclear. The aim of our study was to detect the expression of MGMT and Ku80 on PCNSL by IHC staining and to evaluate ...

  14. Structural and electronic stability of a volleyball-shaped B80 fullerene

    Science.gov (United States)

    Wang, Xiao-Qian

    2010-10-01

    We have studied the structural and electronic characteristics of a volleyball-shaped B80 cage using first-principles density-functional calculations. In contrast to the popularly ratified “magic” B80 buckyball with 20 hexagonal pyramids and 12 hollow pentagons, the volleyball-shaped B80 constitutes 12 pentagonal pyramids, 8 hexagonal pyramids, and 12 hollow hexagons. The B80 volleyball is markedly more stable than the previously assumed magic B80 buckyball, which is attributed to the improved aromaticity associated with the distinct configuration.

  15. Aging and space travel

    Science.gov (United States)

    Mohler, S. R.

    1982-01-01

    The matter of aging and its relation to space vehicle crewmembers undertaking prolonged space missions is addressed. The capabilities of the older space traveler to recover from bone demineralization and muscle atrophy are discussed. Certain advantages of the older person are noted, for example, a greater tolerance of monotony and repetitious activities. Additional parameters are delineated including the cardiovascular system, the reproductive system, ionizing radiation, performance, and group dynamics.

  16. Old age and poverty

    Directory of Open Access Journals (Sweden)

    Vuković Drenka

    2010-01-01

    Full Text Available The process of demographic changes in Serbia is followed by discussions on the need to provide safety at old age and solve the problems of poverty and social exclusion of older citizens. In the current state there are no mechanisms that guarantee an adequate life standard at old age, the consequence of which is a high poverty rate, deteriorating health and limited access to social programs. The results of the Survey on life standard from 2002 and 2007 show that poverty among population in general and pensioners has decreased, while the poverty risk among people older than 65 has increased twice. The restrictive methods of the reforms cause a change in the relation between the pensions and the earnings, so that more and more pensioners receive below average, i.e. minimal pensions. Not all old people are covered by pension insurance so that a significant number (around 400.000 does not have a safe monthly income at all. The state program of financial aid is of modest size and does not provide help to all of the poor. Welfare aid decreases the risk of poverty, but it do not guarantee an adequate level of material security at old age. The low level of minimal and average pensions, the decline of participation in the average earnings and the strict criteria of the social security system have brought to awareness the necessity of 'social pensions' and various help and support programs for the elderly. .

  17. MYB80, a regulator of tapetal and pollen development, is functionally conserved in crops.

    Science.gov (United States)

    Phan, Huy A; Li, Song F; Parish, Roger W

    2012-01-01

    The Arabidopsis AtMYB80 transcription factor (formerly AtMYB103) regulate genes essential for tapetal and pollen development. One of these genes, coding for an aspartic protease (UNDEAD), may control the timing of tapetal programmed cell death (PCD). In crop plants such as rice and wheat, abiotic stresses lead to abnormal tapetal development resulting in delayed PCD. Manipulation of AtMYB80 function has been used to develop a reversible male sterility system applicable to hybrid crop production. MYB80 homologs were cloned from wheat, rice, canola and cotton. The promoters of the homologs drove temporal and spatial expression patterns of the GUS reporter gene in the tapetum and microspores of Arabidopsis anthers identical to the AtMYB80 promoter. A short region is conserved in all five MYB80 promoters. The MYB80 homolog genes, driven by the AtMYB80 or their respective promoters, rescued the atmyb80 mutant, completely restoring male fertility. The canola MYB80 was fused to the EAR (ERF-associated amphiphilic repression) repressor and canola plants transgenic for the construct exhibited premature tapetal degradation and subsequent pollen abortion. The five MYB80 homologs all shared a 44 amino acid sequence immediately adjacent to the R2R3 domain which appears to be necessary for MYB80 function.

  18. Case-control study of factors associated with chronic Chagas heart disease in patients over 50 years of age

    Directory of Open Access Journals (Sweden)

    Silvana de Araújo Silva

    2007-11-01

    Full Text Available A case-control study on chronic Chagas heart disease (CCHD was carried out between 1997 and 2005. Ninety patients over 50 years of age were examined for factors related to (CCHD. Fourty-six patients (51.1% with Chagas heart disease (anomalous ECG were assigned to the case group and 44 (48.9% were included in the control group as carriers of undetermined forms of chronic disease. Social, demographic (age, gender, skin color, area of origin, epidemiological (permanence within an endemic zone, family history of Chagas heart disease or sudden death, physical strain, alcoholism, and smoking, and clinical (systemic hypertension variables were analyzed. The data set was assessed through single-variable and multivariate analysis. The two factors independently associated with heart disease were age - presence of heart disease being three times higher in patients over 60 years of age (odds ratio, OR: 2.89; confidence interval of 95%: 1.09-7.61 - and family history of Chagas heart disease (OR: 2.833, CI 95%: 1.11-7.23. Systemic hypertension and gender did not prove to hold any association with heart disease, as neither did skin color, but this variable showed low statistical power due to reduced sample size.

  19. Biology of cancer and aging.

    Science.gov (United States)

    Holmes, F F; Wilson, J; Blesch, K S; Kaesberg, P R; Miller, R; Sprott, R

    1991-12-01

    The greatest risk factor for cancer is aging. Human cancer incidence increases exponentially with advancing age. Cancer growth rate and potential for metastatic spread may be influenced by age-specific change in host response. Because cancer and aging are, thus, inextricably linked, the American Cancer Society should encourage submission of research proposals that address the mechanisms of aging and how aging alters cancer development.

  20. Effect of Age on Hypertension: Analysis of Over 4,800 Referred Hypertensive Patients

    Directory of Open Access Journals (Sweden)

    Anderson Gunnar

    1999-01-01

    Full Text Available We evaluate in this study the factors associated with the effect of age on blood pressure in more than 4800 patients. Their physicians referred them to evaluate for secondary causes for their hypertension. Factors studied included history and physical examination, serum sodium, potassium and creatinine, a stimulated plasma renin and catecholamine. We also studied the blood pressure response to infusion of either saralasin (an angiotensin II analogue or enalapril (an angiotensin converting enzyme inhibitor, and plasma aldosterone and cortisol after infusion of saline. We measured serum thyroxin and thyroid stimulating hormone concentrations on 1061 consecutive patients in this series. The results of our study show that increased age is associated with a significant increase in the prevalence of hypertension and especially of systolic hypertension after age 60 years. Increased obesity between age 30-50 years is associated with significant increases in diastolic blood pressure and this trend is also seen in African-Americans who are heavier than whites. Increased age is associated with an increased prevalence of secondary forms of hypertension including atherosclerotic renovascular hypertension, renal insufficiency and primary hypothyroidism.

  1. Aging, exercise, and attention.

    Science.gov (United States)

    Hawkins, H L; Kramer, A F; Capaldi, D

    1992-12-01

    The authors investigated the relationship among aging, attentional processes, and exercise in 2 experiments. First they examined age differences on 2 attentional tasks, a time-sharing task and an attentional flexibility task. Young adults alternated attention between 2 sequenced tasks more rapidly and time-shared the processing of 2 tasks more efficiently than older adults. They then investigated the effects of aerobic exercise on the same 2 attentional tasks in older adults. Following the 10-week exercise program, older exercisers showed substantially more improvement in alternation speed and time-sharing efficiency than older controls. Interestingly, this exercise effect was specific to dual-task processing. Both groups of subjects showed equivalent effects on single-task performance. These results indicate that aerobic exercise can exert a beneficial influence on the efficiency of at least 2 different attentional processes in older adults. PMID:1466833

  2. Cognitive Reserve Scale and ageing

    Directory of Open Access Journals (Sweden)

    Irene León

    2016-01-01

    Full Text Available The construct of cognitive reserve attempts to explain why some individuals with brain impairment, and some people during normal ageing, can solve cognitive tasks better than expected. This study aimed to estimate cognitive reserve in a healthy sample of people aged 65 years and over, with special attention to its influence on cognitive performance. For this purpose, it used the Cognitive Reserve Scale (CRS and a neuropsychological battery that included tests of attention and memory. The results revealed that women obtained higher total CRS raw scores than men. Moreover, the CRS predicted the learning curve, short-term and long-term memory, but not attentional and working memory performance. Thus, the CRS offers a new proxy of cognitive reserve based on cognitively stimulating activities performed by healthy elderly people. Following an active lifestyle throughout life was associated with better intellectual performance and positive effects on relevant aspects of quality of life.

  3. Endodontics and the ageing patient.

    Science.gov (United States)

    Johnstone, M; Parashos, P

    2015-03-01

    Patients are living longer and the rate of edentulism is decreasing. Endodontic treatment is an essential part of maintaining the health and well-being of the elderly. Retention of natural teeth improves the quality of life and the overall health and longevity of ageing patients. Also, teeth that might be otherwise extracted may be strategically valuable to retain a prosthesis, and elderly patients are more likely to have medical complications that may prevent dental extractions from being safely performed. The technical goals of endodontic treatment in the elderly are the same as those for younger patients. However, the pulpo-dentinal complex undergoes calcific changes over time, which may pose challenges for the clinician. The purposes of this review are to discuss age changes in the pulp and the challenges posed by diagnosing, treatment planning and treating the elderly endodontic patient. PMID:25762039

  4. Blood rheology and aging

    OpenAIRE

    Başkurt, Oğuz K.; Simmonds, Michael J. ; Meiselman, Herbert J.

    2013-01-01

    Journal of Geriatric Cardiology (2013) 10: 291301 ©2013 JGC All rights reserved; www.jgc301.com http://www.jgc301.com; | Journal of Geriatric Cardiology Review  Open Access  Blood rheology and aging Michael J. Simmonds1, Herbert J. Meiselman2, Oguz K. Baskurt3 1Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Gold Coast, QLD 4222, Australia 2Department of Physiology and Biophysics, Keck School of Medicine, University of S...

  5. Spin-orbit ab initio curves of 80Se+2 ion and the assignment of photoelectron spectra of 80Se2 molecule

    Institute of Scientific and Technical Information of China (English)

    Yan Bing; Pan Shou-Fu; Guo Qing-Qun

    2008-01-01

    This paper carries out ab initio calculations to study the 80Se2(X3∑-g)state and 80Se+2(X2∏g),80Se+2(a4∏g)states by using completed active space self-consistent field and multi-reference second order perturbation theory.The electronic curves of these states including spin-orbit coupling are calculated,and then the spectroscopic parameters are obtained.The photoelectron spectra of 80Se2 molecule in gas phase are assigned according to Franck-Condon analysis based on calculated potential energy curves.The ionization energies of 80Se2 molecule are determined by the present calculation.

  6. Three Essays on Age and Firm Performance

    OpenAIRE

    Zeller, Jonas

    2014-01-01

    Old captains at the helm: Chairman age and firm performance Urs Waelchli and Jonas Zeller December, 2012 This paper examines whether the chairmen of the board (COBs) impose their life-cycles on the firms over which they preside. Using a large sample of unlisted firms we find a robust negative relation between COB age and firm performance. COBs age much like ‘ordinary’ people. Their cognitive abilities deteriorate and they experience significant shifts in motivation. Deteriorating cog...

  7. Aging in chalcohalide glasses: Origin and consequences

    DEFF Research Database (Denmark)

    Jensen, Martin; Smedskjær, Morten Mattrup; Wang, W.;

    2012-01-01

    The application of chalcogenide and chalcohalide glasses is limited by their uncontrolled drift in properties over time due to aging processes. In the present work, we perform aging experiments on some chalcohalide glasses in oxidizing, inert and reducing atmospheres and afterwards we measure the...

  8. Proinsulin and age in general population

    OpenAIRE

    Ateia, S; E. Rusu; Cristescu, V; Enache, G; Cheța, DM; Radulian, G.

    2013-01-01

    Abstract Objective. The objective of this study was to assess the relationship between fasting proinsulin (PI) and age in general population and to determine whether there are differences regarding this association in obese and non-obese persons. Methods. A random population-based sample (n=656) of Romanians (26–80 years) living in Bucharest, Romania was studied; 432 persons had diabetes and they were not analyzed in this paper. Circulating levels of fasting plasma glucose (FPG), fasting plas...

  9. Needs for prosthetic treatment in Vilnius population at the age over 45 years old.

    Science.gov (United States)

    Sveikata, Kestutis; Balciuniene, Irena; Tutkuviene, Janina

    2012-01-01

    AIM OF THE STUDY. The aims of the study was to evaluate needs for prosthetic treatment among middle-aged and elderly population in Vilnius, to find out rates of edentulism among Vilnius inhabitants and to ask them about their approach to personal oral hygiene. MATERIALS AND METHODS. This cross-sectional study was approved by Lithuanian Bioethics Committee and carried out by one investigator. Our study was performed in period from 2008 to 2012. We have examined and interviewed 634 patients in the principle of free choice (randomized selection). Quantity of remaining teeth and previous prosthetic treatment was assessed. RESULTS. According to questionnaire previous prosthetic treatment was attached for 204 (43.8%) male and 262 (56.8%) female patients, total 466 (73.5%) of all subjects involved into our research, 168 (26.5%) never had a prosthetic treatment. During examination we found, that 219 (34.5%) of all examined persons were treated with removable prosthesis, 180 (28.4%) treated with fixed prosthesis and for 67 (10.6%) both: fixed and removable kinds of prosthesis were attached. Toothless jaws were found in 26.5% (n = 168) of population. We found 179 (28.2%) edentulous maxillas and 168 (26.5%) mandibles. CONCLUSIONS. The intensity of tooth loss in the middle-aged and eldery population of Vilnius city significantly increases with age. Lower rates of edentulism and an ageing population mean that older people will feature more prominently in dental services. Consolidation in oral health perceptions starts before age 50, suggesting early intervention before that age. PMID:23128489

  10. Providing and financing aged care in Australia

    Directory of Open Access Journals (Sweden)

    Ergas H

    2011-06-01

    Full Text Available Henry Ergas1,2, Francesco Paolucci31University of Wollongong, Wollongong, NSW, Australia; 2Deloitte Australia, Brindabella Business Park, Canberra Airport, ACT, Australia; 3Australian Centre for Economic Research on Health, The Australian National University, Acton, Canberra, ACT, AustraliaAbstract: This article focuses on the provision and financing of aged care in Australia. Demand for aged care will increase substantially as a result of population aging, with the number of Australians aged 85 and over projected to increase from 400,000 in 2010 to over 1.8 million in 2051. Meeting this demand will greatly strain the current system, and makes it important to exploit opportunities for increased efficiency. A move to greater beneficiary co-payments is also likely, though its extent may depend on whether aged care insurance and other forms of pre-payment can develop.Keywords: aged care, long-term care, sustainability, residential care, community care

  11. Relationship between tooth loss and mortality in 80-year-old Japanese community-dwelling subjects

    Directory of Open Access Journals (Sweden)

    Torisu Takehiro

    2010-07-01

    Full Text Available Abstract Background Findings from several studies suggest associations between tooth loss and health outcomes, including malnutrition, poor quality of life, and mortality, in older individuals. However, limited information is available regarding whether those associations remain true in very elderly subjects after adequately considering confounding factors such as sex and smoking status. Herein, we determined whether the number of teeth in 80-year-old subjects is an independent predictor of mortality. Methods We initially contacted 1282 80-year-old community-dwelling individuals born in 1917, of whom 697 responded and participated in a baseline study, with follow-up examinations conducted 4 and 5.5 years later. Data from interviews and medical and oral examinations were obtained, and oral health was determined according to the number of teeth remaining in the oral cavity. Results A total of 108 and 157 subjects died in 4 years and 5.5 years, respectively, after the baseline study. Tooth loss was significantly associated with mortality at age 85.5, but not at age 84, after adjusting for potential confounders. When the analysis was stratified by sex, we found a stronger association in females in follow-up examinations conducted at both 4- and 5.5 years. On the other hand, the effect of tooth loss on mortality was not significantly different between smokers and non-smokers. Conclusion Tooth loss is a significant predictor of mortality independent of health factors, socio-economic status, and lifestyle in octogenarians, with a stronger association in females.

  12. The changing face of orthostatic and neurocardiogenic syncope with age.

    LENUS (Irish Health Repository)

    Cooke, J

    2012-01-31

    AIM: Reports of the outcomes of syncope assessment across a broad spectrum of ages in a single population are scarce. It is our objective to chart the varying prevalence of orthostatic and neurocardiogenic syncope (NCS) as a patient ages. METHODS: This was a retrospective study. All consecutive patients referred to a tertiary referral syncope unit over a decade were included. Patients were referred with recurrent falls or orthostatic intolerance. Tilt tests and carotid sinus massage (CSM) were performed in accordance with best practice guidelines. RESULTS: A total of 3002 patients were included (1451 short tilt, 127 active stand, 1042 CSM and 382 prolonged tilt). Ages ranged from 11 to 91 years with a median (IQR) of 75 (62-81) years. There were 1914 females; 1088 males. Orthostatic hypotension (OH) was the most commonly observed abnormality (test positivity of 60.3%). Those with OH had a median (IQR) age of 78 (71-83) years. Symptomatic patients were significantly younger than asymptomatic (P = 0.03). NCS demonstrated a bimodal age distribution. Of 194 patients with carotid sinus hypersensitivity, the median age (IQR) was 77 (68-82) years. Those with vasovagal syncope (n = 80) had a median (IQR) age of 30 (19-44) years. There were 57 patients with isolated postural orthostatic tachycardia syndrome. Of the total patients, 75% were female. They had a median (IQR) age of 23 (17-29) years. CONCLUSION: We have confirmed, in a single population, a changing pattern in the aetiology of syncope as a person ages. The burden of disease is greatest in the elderly.

  13. E-Learning and the Third Age

    Science.gov (United States)

    Trentin, Guglielmo

    2004-01-01

    As a result of the general improvement in living conditions in industrialised Western countries, people aged over 60 years usually reach the third age in good mental and physical condition. Contemporary society has thus had to endeavour to offer the new old not only social services but also pastimes, leisure, social, cultural and educational…

  14. Composition and structure of the 80S ribosome from the green alga Chlamydomonas reinhardtii: 80S ribosomes are conserved in plants and animals.

    Science.gov (United States)

    Manuell, Andrea L; Yamaguchi, Kenichi; Haynes, Paul A; Milligan, Ronald A; Mayfield, Stephen P

    2005-08-12

    We have conducted a proteomic analysis of the 80S cytosolic ribosome from the eukaryotic green alga Chlamydomonas reinhardtii, and accompany this with a cryo-electron microscopy structure of the ribosome. Proteins homologous to all but one rat 40S subunit protein, including a homolog of RACK1, and all but three rat 60S subunit proteins were identified as components of the C. reinhardtii ribosome. Expressed Sequence Tag (EST) evidence and annotation of the completed C. reinhardtii genome identified genes for each of the four proteins not identified by proteomic analysis, showing that algae potentially have a complete set of orthologs to mammalian 80S ribosomal proteins. Presented at 25A, the algal 80S ribosome is very similar in structure to the yeast 80S ribosome, with only minor distinguishable differences. These data show that, although separated by billions of years of evolution, cytosolic ribosomes from photosynthetic organisms are highly conserved with their yeast and animal counterparts.

  15. Aging and Repeated Thought Suppression Success

    OpenAIRE

    Ann E Lambert; Smyth, Frederick L.; Jessica R Beadel; Teachman, Bethany A.

    2013-01-01

    Intrusive thoughts and attempts to suppress them are common, but while suppression may be effective in the short-term, it can increase thought recurrence in the long-term. Because intentional suppression involves controlled processing, and many aspects of controlled processing decline with age, age differences in thought suppression outcomes may emerge, especially over repeated thought suppression attempts as cognitive resources are expended. Using multilevel modeling, we examined age differe...

  16. 老年听力障碍量表筛查版与完整版结果对比分析%Comparison of HHIE and HHIE-s Results in People over 70 Years of Age

    Institute of Scientific and Technical Information of China (English)

    韩莹; 周其友; 冀飞

    2014-01-01

    Objective To compare the results between Hearing Handicap Inventory for the Elderly (HHIE) and its screening version (HHIE-S) in elderly people over 70 years of age with hearing handicap. Methods One hundred and twenty people over 70 years participated in the survey using HHIE or HHIE-S respectively. Hearing function handicap scores from HHIE and HHIE-S were compared. Results HHIE scores identified 41 subjects with hearing function handicap (mild-to-mod-erate in 24 and maximum in 17). In comparison, HHIE-S identified 39 subjects with hearing function handicap (mild-to-mod-erate in 27 and maximum in 12). No significant difference was found between the results from HHIE and HHIE-S (X2=1.064, P=0.588). Conclusion HHIE-S can be used as a convenient screening tool in investigating hearing handicap in elderly peo-ple, with similar validity as HHIE.%目的:对比老年听力障碍量表完整版(HHIE)与筛查版(HHIE-S)调查问卷结果,探讨更便捷的功能性听力障碍筛检方法。方法对120例70岁以上老年人分别进行老年听力障碍量表HHIE和HHIE-S的问卷调查,对比各自听力障碍分级标准,分别得出听力障碍等级结论。将HHIE结果与HHIE-S结果进行比较。结果根据HHIE功能性听力障碍分级标准,完整版有41例存在听力障碍,其中轻中度24例,重度17例。HHIE-S结果显示39例存在听力障碍,其中轻中度27例,重度12例。HHIE和HHIE-S的功能性听力障碍分级结果无统计学差异(X2=1.064, P=0.588)。结论老年听力障碍量表筛查版(HHIE-S)可以代替完整版进行临床调查,更便于患者信息采集及临床应用。

  17. Ageing and digital games

    DEFF Research Database (Denmark)

    Iversen, Sara Mosberg

    2016-01-01

    of the book is to examine, analyse and discuss: 1) What older adults do with digital games and what meanings the use of digital games take on in the everyday life of older adults; 2) How older adults are perceived by society in relation to digital games; 3) How play and games can be used both......Digital games are still to a great degree considered a medium mainly for young boys. However, available statistics on Western media use show that this is far from the case. Increasingly, people of all ages and genders play digital games, also older adults in their early 60s and beyond. The aim...

  18. 47 CFR 80.110 - Inspection and maintenance of antenna structure markings and associated control equipment.

    Science.gov (United States)

    2010-10-01

    ... structure markings and associated control equipment. The owner of each antenna structure required to be... 47 Telecommunication 5 2010-10-01 2010-10-01 false Inspection and maintenance of antenna structure markings and associated control equipment. 80.110 Section 80.110 Telecommunication FEDERAL...

  19. Successful Aging and Longevity in Older Old Women: The Role of Depression and Cognition

    Directory of Open Access Journals (Sweden)

    Daniel Paulson

    2011-01-01

    Full Text Available Based in successful aging theory and terminal cognitive drop research, this paper investigates cerebrovascular burden (CVB, depressive symptoms, and cognitive decline as threats to longevity. A subsample of stroke-free women over the age of 80 was identified in the Health and Retirement Survey (years 2000–2008. Mortality at 2, 6, and 8 year intervals was predicted using CVB (diabetes, heart disease, hypertension, depressive symptoms (Center for Epidemiological Studies Depression Scale, and cognitive decline (decline of 1 standard deviation or more on the 35-point Telephone Interview for Cognitive Status over 2 years. At most waves (2002, 2004, and 2006 mortality was predicted by CVB, depressive symptoms, and cognitive drop measured 2 years prior. CVB and depressive symptoms at the 2000 wave predicted mortality at 6 and 8 years. Older women with the greatest longevity had low CVB, robust cognitive functioning, and few depression symptoms, supporting successful aging theory and terminal cognitive drop.

  20. Neutron-Capture Kr-80 and Ar-36 in the Martian Atmosphere and Regolith

    Science.gov (United States)

    Rao, M. N.; Bogard, D. D.; Nyquist, L.; McKay, D. S.; Masarik, J.

    2001-01-01

    We calculate that approximately 10% of martian atmospheric Kr-80 formed by neutron capture on Mars in approx. 0.5 Ga. The regolith contains even larger amounts of n-capture Kr-80 and Ar-36, which may provide clues to the evolution of the martian regolith and atmosphere. Additional information is contained in the original extended abstract.

  1. Qos and Voice Over IP

    Directory of Open Access Journals (Sweden)

    Adrian GHENCEA

    Full Text Available As Voice over Internet Protocol (VoIP technology matures, companies are increasingly adopting it to cut costs, improve efficiency and enhance customer service. Using the Internet as an existing network for integrating data and telecom systems through intelligent VoIP, a range of benefits results: lower long distance costs, cost cuts in cabling processes and more flexible telephony management. However, as voice over IP services grow in popularity, major threats arise: this rapid growth leads to traffic congestion, security is jeopardizedand the poor quality of calls affects communication. The objective of this article is to present all the elements that can affect voicequality in a VoIP network and to provide methods for solving them. A detailed analysis to minimize the impact of implementation of QoS will be made, and at the end solutions to management strategies will be proposed.

  2. Dominance and Age in Bilingualism

    Science.gov (United States)

    Birdsong, David

    2014-01-01

    The present article examines the relationship between age and dominance in bilingual populations. Age in bilingualism is understood as the point in development at which second language (L2) acquisition begins and as the chronological age of users of two languages. Age of acquisition (AoA) is a factor in determining which of a bilingual's two…

  3. Production and Drawing of 80 Steel Wire Rod%80钢盘条的生产与拉拔

    Institute of Scientific and Technical Information of China (English)

    马志军; 周桂兰; 曹二转; 张全刚; 琚艳军

    2006-01-01

    介绍高强度80钢盘条的生产工艺流程和力学性能指标,通过金相组织分析,指出钢的组织中出现网状渗碳体是拉拔断裂的主要原因,采用人工时效并改进拉拔工艺,使各道次的压缩率均匀合理,在一定程度上可以弥补组织不当带来的缺陷,有利于盘条的拉拔.

  4. [Feeding and aging].

    Science.gov (United States)

    Sánchez Zaplana, Isabel; Maestre González, Elena

    2013-06-01

    Aging is characterized by an increase in relative population of 65 years and older, and can say that, in our country, it is a phenomenon demographic, political, social and health. Several studies have shown that the nutritional status of the general population and the elderly, in particular, is a valid indicator to predict longevity and quality of life of this group of people. The World Health Organization (who) pointed out that the elderly population is a group nutritionally very vulnerable as a result of anatomical and physiological changes associated with aging. Between 35-40 of the elderly has some kind of altered nutrition or malnutrition: protein or protein-energy malnutrition, selective deficiency of vitamins and minerals, inadequate water intake, obesity, etc. The best way to promote the quality of life and prevent disease is a proper diet, also called healthy eating, adapted to the special circumstances which older persons may present without forgetting gastronomy is not incompatible with health. In this article, some tips are also available for preparing and cooking food, as well as culinary strategies to introduce them in the daily menu.

  5. [Feeding and aging].

    Science.gov (United States)

    Sánchez Zaplana, Isabel; Maestre González, Elena

    2013-06-01

    Aging is characterized by an increase in relative population of 65 years and older, and can say that, in our country, it is a phenomenon demographic, political, social and health. Several studies have shown that the nutritional status of the general population and the elderly, in particular, is a valid indicator to predict longevity and quality of life of this group of people. The World Health Organization (who) pointed out that the elderly population is a group nutritionally very vulnerable as a result of anatomical and physiological changes associated with aging. Between 35-40 of the elderly has some kind of altered nutrition or malnutrition: protein or protein-energy malnutrition, selective deficiency of vitamins and minerals, inadequate water intake, obesity, etc. The best way to promote the quality of life and prevent disease is a proper diet, also called healthy eating, adapted to the special circumstances which older persons may present without forgetting gastronomy is not incompatible with health. In this article, some tips are also available for preparing and cooking food, as well as culinary strategies to introduce them in the daily menu. PMID:23909217

  6. Autophagy in ageing and ageing-associated diseases

    Institute of Scientific and Technical Information of China (English)

    Li-qiang HE; Jia-hong LU; Zhen-yu YUE

    2013-01-01

    Autophagy is a cell self-digestion process via lysosomes that clears "cellular waste",including aberrantly modified proteins or protein aggregates and damaged organelles.Therefore,autophagy is considered a protein and organelle quality control mechanism that maintains normal cellular homeostasis.Dysfunctional autophagy has been observed in ageing tissues and several ageing-associated diseases.Lifespan of model organisms such as yeast,worms,flies,and mice can be extended through promoting autophagy,either by genetic manipulations such as over-expression of Sirtuin 1,or by administrations of rapamycin,resveratrol or spermidine.The evidence supports that autophagy may play an important role in delaying ageing or extending lifespan.In this review,we summarize the current knowledge about autophagy and its regulation,outline recent developments ie the genetic and pharmacological manipulations of autophagy that affects the lifespan,and discuss the role of autophagy in the ageing-related diseases.ow in Center for Neurodegenerative and Neuroimmunologic Diseases,Department of Neurology,University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School,Piscataway,NJ 08854,USA

  7. Aging and intuitive physics.

    Science.gov (United States)

    Léoni, Véronique; Mullet, Etienne; Chasseigne, Gerard

    2002-07-01

    The present study was aimed at comparing the judgment capacities manifested by young adults, middle-aged adults, and elderly people in an everyday life setting implying the consideration of direct as well as inverse relationships between the cues and the criterion. The chosen situation was borrowed from elementary physics and concerned the relationships between mass, volume and density. In forming their estimations of mass, all elderly people were able to use volume and density information. In addition, most of them were able to combine these pieces of information in a correct, multiplicative way. In forming their estimations of volume, all elderly people were able to use mass and density information but a majority of them used the density information in a direct way. By contrast, most young and middle-aged adults correctly used the density information in an inverse way. The findings strengthen and extend the case made by Chasseigne et al. [Acta Psychologica 97 (1997) 235] as regards the trouble elderly people face in using inverse relationships in a judgment situation. The difficulty elderly people face is not confined to learning settings. It may also be observed in ecological, non-learning environments, where the relationships considered do not entirely depend on the experimenter's choice.

  8. Active and Successful Aging: A European Policy Perspective.

    OpenAIRE

    Foster, L; Walker, A

    2014-01-01

    Over the past two decades, "active aging" has emerged in Europe as the foremost policy response to the challenges of population aging. This article examines the concept of active aging and how it differs from that of "successful aging." In particular, it shows how active aging presents a more holistic, life course-oriented approach than successful aging. We provide a critical perspective on active aging too by, first, tracing its emergence in Europe and then showing how, in practice, it has b...

  9. Cluster Analysis of Physical and Cognitive Ageing Patterns in Older People from Shanghai

    Directory of Open Access Journals (Sweden)

    Stephan Bandelow

    2016-02-01

    Full Text Available This study investigated the relationship between education, cognitive and physical function in older age, and their respective impacts on activities of daily living (ADL. Data on 148 older participants from a community-based sample recruited in Shanghai, China, included the following measures: age, education, ADL, grip strength, balance, gait speed, global cognition and verbal memory. The majority of participants in the present cohort were cognitively and physically healthy and reported no problems with ADL. Twenty-eight percent of participants needed help with ADL, with the majority of this group being over 80 years of age. Significant predictors of reductions in functional independence included age, balance, global cognitive function (MMSE and the gait measures. Cluster analysis revealed a protective effect of education on cognitive function that did not appear to extend to physical function. Consistency of such phenotypes of ageing clusters in other cohort studies may provide helpful models for dementia and frailty prevention measures.

  10. Cluster Analysis of Physical and Cognitive Ageing Patterns in Older People from Shanghai.

    Science.gov (United States)

    Bandelow, Stephan; Xu, Xin; Xiao, Shifu; Hogervorst, Eef

    2016-01-01

    This study investigated the relationship between education, cognitive and physical function in older age, and their respective impacts on activities of daily living (ADL). Data on 148 older participants from a community-based sample recruited in Shanghai, China, included the following measures: age, education, ADL, grip strength, balance, gait speed, global cognition and verbal memory. The majority of participants in the present cohort were cognitively and physically healthy and reported no problems with ADL. Twenty-eight percent of participants needed help with ADL, with the majority of this group being over 80 years of age. Significant predictors of reductions in functional independence included age, balance, global cognitive function (MMSE) and the gait measures. Cluster analysis revealed a protective effect of education on cognitive function that did not appear to extend to physical function. Consistency of such phenotypes of ageing clusters in other cohort studies may provide helpful models for dementia and frailty prevention measures. PMID:26907351

  11. Microstructures and mechanical properties of AZ80 alloy treated by pulsed ultrasonic vibration

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Pulsed ultrasonic field was employed in the melt of the AZ80 magnesium alloy. The effects of pulsed ultrasonic field on mierostructure and mechanical properties of AZ80 magnesium alloy were investigated. The results show that the as-cast mierostructure of the AZ80 alloy with pulsed ultrasonic treatment is significantly changed. Pulsed ultrasonic field significantly decreases the grain size, changes the morphologies of the β-Mg17Al12 phases and reduces their area fraction. It is found that pulse width of ultrasonic plays an important role on the microstrueture formation of AZ80 alloy. With increasing pulse width, grains beeome finer and more uniform. In the range of experimental parameters, the optimum pulse width for melt treatment process is found to be 210 μs. The mechanical tests show that the mechanical properties of the as-cast AZ80 magnesium alloy with pulsed ultrasonic treatment are much higher than those of AZ80 alloy without ultrasonic field.

  12. The pachytene checkpoint prevents accumulation and phosphorylation of the meiosis-specific transcription factor Ndt80

    OpenAIRE

    Tung, Kuei-Shu; Hong, Eun-Jin Erica; Roeder, G. Shirleen

    2000-01-01

    In budding yeast, many mutants defective in meiotic recombination and chromosome synapsis undergo checkpoint-mediated arrest at the pachytene stage of meiotic prophase. We recovered the NDT80 gene in a screen for genes whose overexpression bypasses the pachytene checkpoint. Ndt80 is a meiosis-specific transcription factor that promotes expression of genes required for exit from pachytene and entry into meiosis I. Herein, we show that the Ndt80 protein accumulates a...

  13. Food Hypersensitivity in Patients Over 14 Years of Age Suffering from Atopic Dermatitis

    OpenAIRE

    Jarmila Čelakovská; Ettler, K; K Ettlerová; J Vaněčková

    2014-01-01

    Background: Patients suffering from atopic dermatitis often describe food hypersensitivity. Rising prevalence of food hypersensitivity and severe allergic reactions to foods have been reported, but the data are scarce. Aims and Objectives: Evaluation of food hypersensitivity reactions in patients suffering from atopic dermatitis. Materials and Methods: The dermatological examination was performed in patients of age 14 years and above and the detailed history was taken concerning the food hype...

  14. A Compilation and Review of over 500 Geoscience Misconceptions

    Science.gov (United States)

    Francek, Mark

    2013-01-01

    This paper organizes and analyses over 500 geoscience misconceptions relating to earthquakes, earth structure, geologic resources, glaciers, historical geology, karst (limestone terrains), plate tectonics, rivers, rocks and minerals, soils, volcanoes, and weathering and erosion. Journal and reliable web resources were reviewed to discover (1) the frequency of misconceptions by subject matter, group (primary, middle-school, high-school, middle-/high-school, college, pre-service teachers, in-service teachers, and undefined) and source (journal versus web); and (2) the pattern of misconceptions across age groups and (3) directions for future research. A total of 502 misconceptions were discovered, with over 40% targeting a middle- and high-school audience. Plate tectonics comprised 19% of all misconceptions, with another 14% and 13% associated with weathering/erosion and historical geology, respectively. Over 80% of all the misconceptions were derived from peer-reviewed journals or web sources, the rest originated from reliable sources on the World Wide Web. The supernatural origin for many of the geoscience phenomena listed here is abandoned by middle school, but in other cases, some misconceptions seem robust through adulthood. Examples of such misconceptions include the origin/pattern of earthquakes, thickness of the earth's crust, oil's origin, movement mechanisms for glaciers, co-existence of humans and dinosaurs, water movement within karst terrains, the nature of plate boundaries, the power of water as an agent of geomorphic change, what constitutes a mineral and a rock, thickness of the soil layer, the distribution of volcanoes, and the difference between weathering and erosion.

  15. Structural and Functional Implication of RAP80 ΔGlu81 Mutation

    Science.gov (United States)

    Vikrant; Kumar, Rajan; Yadav, Lumbini R.; Nakhwa, Pallavi; Waghmare, Sanjeev K.; Goyal, Peyush; Varma, Ashok K.

    2013-01-01

    Receptor Associated Protein 80 (RAP80) is a member of RAP80-BRCA1-CCDC98 complex family and helps in its recruitment to the DNA damage site for effective homologous recombination repair. It encompasses two tandem UIMs (UIM1 and UIM2) motif at its N-terminus, which interact with K-63 linked polyubiquitin chain(s) on H2AX and thereby assemble the RAP80-BRCA1 complex at the damage site. Nevertheless, how RAP80 helps in the structural integrity of BRCA1 complex is still elusive. Considering the role of RAP80 in the recruitment of BRCA1 complex at the DNA damage site, we attempted to explore the molecular mechanism associated with RAP80 and mutation that causes chromosomal aberrations due to its loss of function. There is a significant loss in structural characteristics of RAP80 ΔE81, which impairs its binding affinity with the polyubiquitin chain. This leads to the defective recruitment of RAP80 and BRCA1 complex at the DNA damage site. The results presented here are very useful in understanding the cause of various repair defects (chromosomal aberration) that arise due to this mutation. Comparative study of wild type and ΔE81 could be helpful in designing the small molecules that can potentially compensate the deleterious effect(s) of ΔE81 and hence useful for therapeutic application. PMID:24039796

  16. HNBR/AO80共混阻尼橡胶的结构和性能%Structure and Properties of Vulcanized HNBR/AO80 Damping Rubbers

    Institute of Scientific and Technical Information of China (English)

    王爽; 张继华; 赵云峰

    2013-01-01

    在氢化丁腈橡胶(HNBR)中添加受阻酚AO80,制备HNBR/AO80共混橡胶,以改善HNBR的阻尼性能.采用DMA和FTIR等方法研究了HNBR/AO80共混硫化体系结构和性能之间的关系,并通过热处理的方法,研究了该体系的稳定性.结果表明:由于AO80的羟基与HNBR的腈基间强氢键作用,使HNBR/AO80硫化体系具有较好的阻尼性能.而热处理后,硫化体系中一些与橡胶分子有氢键作用的AO80,会不断自聚形成AO80的富相区、结晶、长大,形成大的结晶聚集体,导致共混体系的阻尼性能不稳定.%In order to improve the damping properties of hydrogenated nitrilebutadiene rubber (HNBR ) ,3,9-bis[ 1, 1-dimethyl-21 {β-(3-tertbutyl-4-hydroxy-5-methylphenyl) propionyloxy} ethyl ] -2,4,8,10-tetraoxaspi-ro [ 5, 5 ] -undecane (AO80) were added into it to prepare the vulcanized HNBR/AO80 rubbers. The relationship between the damping properties and micro-structure of this blending system was characterized by DMA & FTIR. Then the stability of this system was studied by thermal treatment at 8011. The results showed good damping property of this blending system, which was due to the effect of intermolecular hydrogen bonds between the hydroxyl groups of AO80 and the nitrile groups of HNBR. But the damping property of this curing system become unstable after thermal treated because of the self polymerization of AO80. With the increasing of thermal treated time, large number of AO80 formed rich phase,crystallized,grewed up,then formed large crystallise aggregates.

  17. Chomsky at 80. A tribute

    Institute of Scientific and Technical Information of China (English)

    Mark Lowe

    2008-01-01

    @@ Noam Chomsky published his first book, Syntactic Structures in 1957. It started a revolution in linguistics and profoundly influenced many other fields. Now, 50 years later, Chomsky, at almost 80 years of age, is still regarded as a revolutionary. Mark Lowe pays a personal tribute.

  18. A investigation report on risk factors of stroke in people aged 60 and over in Guiyang%贵阳市60岁以上人群脑卒中危险因素调查分析

    Institute of Scientific and Technical Information of China (English)

    代鸣明; 楚兰; 刘芳; 朱英武; 方旭明

    2013-01-01

    目的 了解贵阳市城乡≥60岁人群脑卒中相关危险因素的暴露情况及分布规律.方法 采用整群随机方法对两个街道办事处和一个镇的60岁及以上常住居民进行调查,包括一般情况及脑卒中相关危险因素的调查,描述脑卒中危险因素的城乡分布特征.结果 城市老年人群高血压、心脏病、高血糖、血脂异常、超重或肥胖、卒中家族史、吸烟、饮酒、喜盐、喜脂等危险因素的暴露率分别为39.66%、4.53%、17.12%、8.63%、33.11%、1.31%、30.05%、17.60%、8.16%、8.99%;农村老年人群分别为43.6%、2.45%、14.50%、6.47%、22.63%、1.09%、45.73%、33.02%、19.74%、26.92%.临床指标中,高血压暴露率农村高于城市,其余各因素城市暴露率高于农村(P<0.05).生活行为因素中,农村地区暴露率高于城市(P<0.05).结论 贵阳市60岁以上人群脑卒中危险因素中高血压暴露率最高,其次为吸烟,而超重或肥胖也已称为不容忽视的重要因素.农村老年人群生活行为因素暴露率高,这也可能是近年来农村地区脑卒中患病率迅速上升的原因之一.%Objective To investigate the characteristic exposure and distribution characteristics of stroke-related risk factors in People aged 60 and above in urban and rural areas of Guiyang.Methods Two street offices and a town resident population aged 60 and over were selected by cluster sampling method.The information about general,and stroke-related risk factors were investigated.Describe the distribution characteristics of risk factors for stroke in urban and rural areas.Results Exposure rates of hypertension,heart disease,high blood sugar,dyslipidemia,overweight or obese,family history of stroke,smoking history,drinking history,high-salt diet,high-fat diet in urban elderly were 39.66%,4.53%,17.12%,8.63%,33.11%,1.31%,30.05%,17.60%,8.16%,8.99%,and in rural 43.6%,2.45%,14.50

  19. On ageing and old age in Serbia

    Directory of Open Access Journals (Sweden)

    Rašević Mirjana

    2010-01-01

    Full Text Available The Serbian population (exclusive of Kosovo and Metohia region is among the oldest populations in the world. More than 950,000 individuals in the Central Serbia and about 300,000 individuals in Vojvodina, or one sixth of both populations are 65 plus. The findings of representative surveys carried out recently pointed out that poverty and poor institutional and instrumental support are the main issues of the elderly population in Serbia. The poverty rate among the elderly is high (9.6 percent and significantly higher than average (6.6. In the meantime, the coverage of poor elderly in Serbia with material provisioning of the family (MPF, the most important measure of the state's social policy, is low due to lack of information of potential beneficiaries, difficulties in collecting all necessary documents as well as strict criteria in connection to means and income tests necessary for exercising the right on this social benefit. Not only that the MPF coverage of poor elderly is inadequate, the amount of this social benefit is also very low. Parallel interviews with 826 elderly persons of 70 and over demonstrate that, although four out of five elderly are chronic patients, the majority of respondents evaluates that they are capable of living in their own households. However, a substantial number of the elderly, every fourth, needs some kind of assistance services with a view to daily functioning at home or in local community. Respondents mainly rely on family in resolving daily problems. A family provides greatest help and support regardless of the fact that such elderly person lives alone or not. Significant factors of support to elderly are friends and neighbors of such persons. Institutions have only a marginal role in the elderly support network. .

  20. [Lung cancer before 40 years and after 80 years: surgical aspects].

    Science.gov (United States)

    Foucault, C; Berna, P; Bagan, P; Mostapha, A; Das Neves-Pereira, J-C; Riquet, M

    2007-10-01

    Lung cancer rarely affects patients at the extreme ages of life. However, changes in epidemiology and therapy led us to review characteristics of both these younger and older populations. We retrospectively reviewed epidemiologic, clinical and pathological characteristics of patients aged 40 years or less (group 1, n=113) and 80 years or more (group 2, n=78) who underwent surgery between 1983 and 2003. Carcinoid tumors were more frequent in the group 1 (n=59 vs 5). Non small cell lung cancer (NSCLC) occurrence rates decreased with time in group 1, whereas increasing rates were observed in group 2 (p=0.0017). Concomitant diseases were significantly more frequent in group 2. The pneumonectomy rates of non small cell lung cancer were the same in each group (group 1, 35.5%; group 2, 34.8%). Five-year survival rates were better in group 1 (58.9% vs 30%, p=0.0048). No 5-year survival was observed for N2 disease in group 2 and mortality unrelated to cancer was more frequent in this group. Otherwise, both groups were similar except for higher rates of adenocarcinomas in group 1. Lung cancer is more and more frequent in the octogenarians. Surgery remains the best treatment in this population except in case of stage III due to N2 involvement.

  1. Aging and repeated thought suppression success.

    Directory of Open Access Journals (Sweden)

    Ann E Lambert

    Full Text Available Intrusive thoughts and attempts to suppress them are common, but while suppression may be effective in the short-term, it can increase thought recurrence in the long-term. Because intentional suppression involves controlled processing, and many aspects of controlled processing decline with age, age differences in thought suppression outcomes may emerge, especially over repeated thought suppression attempts as cognitive resources are expended. Using multilevel modeling, we examined age differences in reactions to thought suppression attempts across four thought suppression sequences in 40 older and 42 younger adults. As expected, age differences were more prevalent during suppression than during free monitoring periods, with younger adults indicating longer, more frequent thought recurrences and greater suppression difficulty. Further, younger adults' thought suppression outcomes changed over time, while trajectories for older adults' were relatively stable. Results are discussed in terms of older adults' reduced thought recurrence, which was potentially afforded by age-related changes in reactive control and distractibility.

  2. Aging and repeated thought suppression success.

    Science.gov (United States)

    Lambert, Ann E; Smyth, Frederick L; Beadel, Jessica R; Teachman, Bethany A

    2013-01-01

    Intrusive thoughts and attempts to suppress them are common, but while suppression may be effective in the short-term, it can increase thought recurrence in the long-term. Because intentional suppression involves controlled processing, and many aspects of controlled processing decline with age, age differences in thought suppression outcomes may emerge, especially over repeated thought suppression attempts as cognitive resources are expended. Using multilevel modeling, we examined age differences in reactions to thought suppression attempts across four thought suppression sequences in 40 older and 42 younger adults. As expected, age differences were more prevalent during suppression than during free monitoring periods, with younger adults indicating longer, more frequent thought recurrences and greater suppression difficulty. Further, younger adults' thought suppression outcomes changed over time, while trajectories for older adults' were relatively stable. Results are discussed in terms of older adults' reduced thought recurrence, which was potentially afforded by age-related changes in reactive control and distractibility. PMID:23776442

  3. Lung cancer incidence among A-bomb survivors in Hiroshima and Nagasaki, 1950 - 80

    International Nuclear Information System (INIS)

    The incidence of lung cancer during 1950 - 80 in a cohort of Japanese atomic bomb survivors and controls was investigated. A total of 1,057 cases were identified; 608 of these diagnoses were based on some form of histopathologic examination, and 442 were confirmed by the present investigators. The distributions of histological types varied significantly between the sexes (p < .001), with adenocarcinoma more frequent among women and epidermoid and small cell carcinoma more frequent among men. The distributions of primary sites did not differ significantly between the sexes. The relative risk (RR) of lung cancer increased significantly with A-bomb radiation dose (p < .0001); based on tentative 1965 dose estimates as revised in 1978 (T65DR) and a linear RR model, the estimated RR at 100 rad (± SE) is 1.41 ± 0.09. Among Hiroshima survivors the women experienced radiation-related excess RR nearly twice as great as men (p = .06). RR increased with decreasing age at the time of bombing (p = .07), and after allowing for this effect, there was no significant evidence that RR varied systematically with attained age. Small cell carcinoma displayed somewhat greater sensitivity to radiation than did adenocarcinoma or epidermoid carcinoma; however the variation between the histology-specific RR functions was not statistically significant (p = .44). (author)

  4. Unmaking old age: political and cognitive formats of active ageing

    DEFF Research Database (Denmark)

    Lassen, Aske Juul; Moreira, Tiago

    2014-01-01

    Active ageing is a policy tool that dominates the way the ageing society has been constituted during the last decades. The authors argue that active ageing is an attempt at unmaking the concept of old age, by engaging in the plasticity of ageing in various ways. Through a document study...... and political in the way they aim at unmaking both the structures and the expectations that has made old age and format a new ideal of the ‘good late life’. The paper examines the role of knowledge in policy and questions whether the formats of active ageing should be made to co-exist, or whether the diversity...... of the different epistemes, models and forms used in the constitution of active ageing policies, the authors show how active ageing is not one coordinated set of policy instruments, but comes in different formats. In the WHO, active ageing configures individual lifestyle in order to expand the plasticity of ageing...

  5. 21 CFR 80.35 - Color additive mixtures; certification and exemption from certification.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Color additive mixtures; certification and exemption from certification. 80.35 Section 80.35 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... number assigned by the Food and Drug Administration to the certified straight color components, but...

  6. 21 CFR 101.80 - Health claims: dietary noncariogenic carbohydrate sweeteners and dental caries.

    Science.gov (United States)

    2010-04-01

    ...) and 1 CFR part 51. You may obtain copies from Karger AG Publishing Co., P.O. Box, Ch-4009 Basel... sweeteners and dental caries. 101.80 Section 101.80 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT... caries. (a) Relationship between dietary carbohydrates and dental caries. (1) Dental caries, or...

  7. Molecular and biochemical characterization of xrs mutants defective in Ku80.

    Science.gov (United States)

    Singleton, B K; Priestley, A; Steingrimsdottir, H; Gell, D; Blunt, T; Jackson, S P; Lehmann, A R; Jeggo, P A

    1997-01-01

    The gene product defective in radiosensitive CHO mutants belonging to ionizing radiation complementation group 5, which includes the extensively studied xrs mutants, has recently been identified as Ku80, a subunit of the Ku protein and a component of DNA-dependent protein kinase (DNA-PK). Several group 5 mutants, including xrs-5 and -6, lack double-stranded DNA end-binding and DNA-PK activities. In this study, we examined additional xrs mutants at the molecular and biochemical levels. All mutants examined have low or undetectable levels of Ku70 and Ku80 protein, end-binding, and DNA-PK activities. Only one mutant, xrs-6, has Ku80 transcript levels detectable by Northern hybridization, but Ku80 mRNA was detectable by reverse transcription-PCR in most other mutants. Two mutants, xrs-4 and -6, have altered Ku80 transcripts resulting from mutational changes in the genomic Ku80 sequence affecting RNA splicing, indicating that the defects in these mutants lie in the Ku80 gene rather than a gene controlling its expression. Neither of these two mutants has detectable wild-type Ku80 transcript. Since the mutation in both xrs-4 and xrs-6 cells results in severely truncated Ku80 protein, both are likely candidates to be null mutants. Azacytidine-induced revertants of xrs-4 and -6 carried both wild-type and mutant transcripts. The results with these revertants strongly support our model proposed earlier, that CHO-K1 cells carry a copy of the Ku80 gene (XRCC5) silenced by hypermethylation. Site-directed mutagenesis studies indicate that previously proposed ATP-binding and phosphorylation sites are not required for Ku80 activity, whereas N-terminal deletions of more than the first seven amino acids result in severe loss of activities. PMID:9032253

  8. Adult Graduates' Negotiations of Age(ing) and Employability

    Science.gov (United States)

    Siivonen, Päivi; Isopahkala-Bouret, Ulpukka

    2016-01-01

    In this article, we will explore Finnish adult graduates' social positioning in relation to age and ageing, and the new discursive framing of employability that is firmly expressed in national as well as in European policy agendas. Age is here understood as a social construction and ageing as a lifelong process. We will analyse our joint interview…

  9. 40 CFR 80.580 - What are the sampling and testing methods for sulfur?

    Science.gov (United States)

    2010-07-01

    ... listed in this section as prescribed in 5 U.S.C. 552(a) and 1 CFR part 51. Anyone may inspect copies at... methods for sulfur? 80.580 Section 80.580 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... the sampling and testing methods for sulfur? The sulfur content of diesel fuel and diesel...

  10. Is tuberculin testing before BCG vaccination necessary for children over three months of age?

    LENUS (Irish Health Repository)

    Hennessy, B

    2008-03-01

    In July 2007 Irish national policy changed such that children aged 3 months to 6 years no longer routinely require tuberculin (Mantoux) skin testing prior to BCG vaccination. Previous to that a tuberculin test was required in all children in this age group pre vaccination. While the previous policy was in place this study was conducted to assess the value of this test. The observation that children are frightened by the test (an injection into the skin) prompted the study. The author conducted a retrospective study of the results of 1,854 tuberculin tests performed as a prerequisite to BCG vaccination and found that only 0.7% of children had a positive test result (induration > 5mm). None of 107 children < 6 years of age tested positive. Those > 12 years were more likely to test positive than younger children (1.09% vs 0.4% respectively, p < 0.05). This study suggests that testing young children before BCG vaccination has a low yield of positive results and adds little to the detection of latent or active TB.

  11. Amendment 80 Permit Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Amendment 80 Program was adopted by the North Pacific Fishery Management Council (Council) in June 2006. The final rule implementing Amendment 80 published in...

  12. Vitamin D and Aging

    OpenAIRE

    Gallagher, J. Christopher

    2013-01-01

    Aging affects the formation of 1,25-dihydroxyvitamin D (1,25[OH]2D; calcitriol), the active form of vitamin D. Production of 1,25(OH)2D is reduced by 50% as a result of an age-related decline in renal function, although serum 1,25(OH)2D levels are maintained in part by secondary hyperparathyroidism. Aging also causes a decrease in calcium absorption that precedes the decrease in 1,25(OH)2D by 10 to 15 years. Because 1,25(OH)2D is dependent on an adequate supply of the substrate vitamin D, the...

  13. Development and characterization of mouse monoclonal antibodies reactive with chicken CD80

    Science.gov (United States)

    CD80 is one of the ligands for CD28 and is an important co-stimulator molecule on antigen presenting cells necessary for T-cell activation. Although CD80 is well characterized in human, swine, ovine, feline, and canine species, there is no information on its chicken counterpart. This study was car...

  14. 47 CFR 80.357 - Working frequencies for Morse code and data transmission.

    Science.gov (United States)

    2010-10-01

    ... frequencies for Morse code and data transmission. This section describes the working frequencies assignable to... 47 Telecommunication 5 2010-10-01 2010-10-01 false Working frequencies for Morse code and data transmission. 80.357 Section 80.357 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY...

  15. 40 CFR 73.80 - Operation of allowance reserve program for conservation and renewable energy.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Operation of allowance reserve program for conservation and renewable energy. 73.80 Section 73.80 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Energy Conservation and Renewable Energy Reserve §...

  16. Physical and mental health at third age - risk factors

    OpenAIRE

    Manolescu Suzana; Rada Cornelia

    2011-01-01

    Objectives: Identifying biological and socio-demographic factors influencing old people’s health stateand their impact on their life; psychological eva