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Sample records for aged 80 and over

  1. Pharmacokinetics of Vancomycin in Elderly Patients Aged over 80 Years.

    Science.gov (United States)

    Bourguignon, Laurent; Cazaubon, Yoann; Debeurme, Guillaume; Loue, Constance; Ducher, Michel; Goutelle, Sylvain

    2016-08-01

    Since the 1950s, vancomycin has remained a reference treatment for severe infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus Vancomycin is a nephrotoxic and ototoxic drug mainly eliminated through the kidneys. It has a large interindividual pharmacokinetic variability, which justifies monitoring its plasma concentrations in patients. This is especially important in patients aged over 80 years, who frequently have renal impairment. However, the pharmacokinetics of vancomycin in this population is very poorly described in the literature. The objective of this work was to propose a model able to predict the pharmacokinetics of vancomycin in very elderly people. First, a population pharmacokinetic model was carried out using the algorithm NPAG (nonparametric adaptive grid) on a database of 70 hospitalized patients aged over 80 years and treated with vancomycin. An external validation then was performed on 41 patients, and the predictive capabilities of the model were assessed. The model had two compartments and six parameters. Body weight and creatinine clearance significantly influenced vancomycin volume of distribution and body clearance, respectively. The means (± standard deviations) of vancomycin volume of distribution and clearance were 36.3 ± 15.2 liter and 2.0 ± 0.9 liter/h, respectively. In the validation group, the bias and precision were -0.75 mg/liter and 8.76 mg/liter for population predictions and -0.39 mg/liter and 2.68 mg/liter for individual predictions. In conclusion, a pharmacokinetic model of vancomycin in a very elderly population has been created and validated for predicting plasma concentrations of vancomycin.

  2. Impact of acute ischemic stroke treatment in patients over age 80: the SPOTRIAS consortium experience

    Science.gov (United States)

    Willey, Joshua Z; Ortega-Gutierrez, Santiago; Petersen, Nils; Khatri, Pooja; Ford, Andria L; Rost, Natalia S; Ali, Latisha K; Gonzales, Nichole R; Merino, Jose G; Meyer, Brett C; Marshall, Randolph S

    2012-01-01

    Background and Purpose Few studies have addressed outcomes among patients ≥80 years treated with acute stroke therapy. In this study, we outline in-hospital outcomes in (1) patients ≥80 years compared to their younger counterparts, and (2) those over age 80 receiving intra-arterial therapy (IAT) compared to those treated with intravenous recombinant tissue plasminogen activator (IVrtPA). Methods Stroke centers within the Specialized Program of Translational Research in Acute Stroke (SPOTRIAS) prospectively collected data on all patients treated with IVrtPA or IAT from 1/1/2005 to 12/31/2010. IAT was defined as receiving any endovascular therapy; IAT was further divided into bridging therapy (BT) when the patient received both IAT and IVrtPA, and endovascular therapy alone (ETA). In-hospital mortality was compared in (1) all patients age80 versus younger counter-parts, and (2) IAT, BT, and ETA versus IVrtPA only among those age80 using multivariable logistic regression. An age-stratified analysis was also performed. Results A total of 3768 patients were included in the study; 3378 were treated with IVrtPA alone, 808 with IAT (383 with ETA and 425 with BT). Patients ≥80 (n=1182) had a higher risk of in-hospital mortality compared to younger counterparts regardless of treatment modality (OR 2.13, 95%CI 1.60–2.84). When limited to those age80, IAT (OR 0.95, 95%CI 0.60–1.49), BT (OR 0.82, 95%CI 0.47–1.45), or ETA (OR 1.15, 95%CI 0.64–2.08) versus IVrtPA were not associated with increased in-hospital mortality Conclusions IAT does not appear to increase the risk of in-hospital mortality among those over age 80 compared to intravenous thrombolysis alone. PMID:22798327

  3. Analysis of complications and outcomes after pulmonary resection in patients aged 80 years or over with non-small cell lung cancer

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    Wen-bing LI

    2014-10-01

    Full Text Available Objective To explore the therapeutic effect and degree of safety in patients aged 80 years or over with nonsmall cell lung cancer undergoing radical resection. Methods A retrospective survey of 97 elder patients aged 80 years or over, in whom non-small cell lung cancer was pathologically confirmed after partial resection of the lung in Chinese PLA General Hospital from Jan. 2003 to Dec. 2012. The peri-operative features were evaluated, including gender, age, history of smoking, pulmonary function, surgical procedure, histopathologic type, pathologic stage, etc. The relation of the postoperative complications and mortality with the factors mentioned above was analyzed. Results Among all patients, the surgical procedure comprised 36 lobectomies, 31 segmentectomies, and 30 wedge resections. The histopathologic diagnosis showed there were adenocarcinoma in 51 patients, squamous cell carcinoma in 29, large cell carcinoma in 9, adenosquamous cell carcinoma in 6 and neuro-endocrine cell carcinomas in 2. The disease stage was determined as ⅠA in 55 cases, ⅠB in 33, ⅡA in 7, ⅢA in 2. The post-operative complications (POC occurred in 14 of 97 patients (14.4%, and the most common complication was cardiovascular complication (9 cases, followed by pulmonary complication (5 cases. Only two patients died to the complications, one of them was post-operative pneumonia and respiratory failure, and the other one was acute myocardial infarction. The survival rate of the 97 patients was 91.7%, 70.2% and 52.8% at 1, 3 and 5 years, respectively, and in the patients with stage I disease, the survival rate was 93.9%, 73.6% and 54.1%, respectively. Conclusion Advanced age is not a contraindication to radical pulmonary resection in patients over 80 years old suffering from early stage non-small cell lung cancer. DOI: 10.11855/j.issn.0577-7402.2014.10.13

  4. The experience of diagnosis and treatment of breast cancer in women aged over 80%80岁以上妇女乳腺癌诊治体会

    Institute of Scientific and Technical Information of China (English)

    崔学斌; 王宁

    2016-01-01

    Objective Discusses the characteristics of over 80 years old women breast cancer.Method Comparative analysis of clinical data of June 2011 to 2013 December treatment of 56 patients over the age of 80 elderly breast cancer patients (elderly group) and compared with 827 cases of other age breast cancer patients (non elderly group), observe two groups of patients with postoperative situation, chemotherapy, postoperative pathology.Result Age group of patients with postoperative flap necrosis, wound infection, limb edema, venous thrombosis and postoperative hospitalization time and non elderly group, the difference is not significant.Conclusion For more than 80 elderly women breast cancer, as long as the perioperative preparation, control the operation time, surgery is safe, for hormone receptor positie, oral anastrozole can.%目的:探讨80岁以上妇女乳腺癌的术后特点。方法对比分析2011年6月至2013年12月就诊的56例80岁以上乳腺癌患者(高龄组)与同期827例其他年龄乳腺癌患者(非高龄组)的临床资料,观察两组患者的术后情况、放化疗情况、术后病理情况。结果高龄组患者术后皮瓣坏死、切口感染、患侧上肢水肿、静脉血栓以及术后住院时间方面与非高龄组比较,差异不具有显著性。结论对于80岁以上妇女乳腺癌,只要做好围术期准备,控制好手术时间,手术是安全的。

  5. Analysis of serum microelement in patients aged 80 years and over%高龄老年人血液中微量元素含量分析

    Institute of Scientific and Technical Information of China (English)

    姜凤久; 曹禹; 任向阳

    2014-01-01

    Objective To compare the serum microelement changes between patients aged80years and adults aged < 60 years,and to compare the levels of serum microelement,total protein,albumin,hemoglobin between the long term in-bed and non in-bed oldest patients.Methods Beijing Bohui BH5100 type atomic absorption spectrometer was used to determine serum microelement.Total protein,albumin,hemoglobin were also determined.Results The amounts of ferrum,zinc,calcium,copper,magnesium were (7.21 ± 1.21) mmol/L,(93.29 ± 10.96)mmol/L,(1.63 ± 0.21)mmol/L,(17.31±3.61)mmol/L,(1.49±0.20)mmol/L in people aged over 80 years,(8.91±1.25)mmol/L,(121.85±11.24)mmol/L,(1.51±0.23)mmol/L,(15.89±3.87)mmol/L,(1.51±0.21)mmol/L in people aged less than 60 years,respectively.The ratios of Ferrum deficiency were 42.9 %,zinc deficiency 14.3%,calcium deficiency 21.4%,copper deficiency 14.3% in oldest-old,whereas were 9.1%,13.6 %,31.8%,27.3% in people aged less than 60 years.The amount of ferrum was significantly lower in people aged over 80 years than in people aged less than 60 years (P<0.01).Proportion of ferrum deficiency was higher in patients aged over 80 years (P<0.01).The amount of calcium and copper was markedly lower in people aged less than 60 years than in people aged over 80 years (P<0.01).The proportions of calcium,copper deficiency were higher in people aged less than 60 years (P<0.01).The amounts of ferrum,zinc,total protein,albumin,hemoglobin of the patients aged over 80 years in long-term in-bed group were significant decreased as compared with those of people in non long-term in-bed group [(6.44±0.89)mmol/L vs.(8.16±1.16)mmol/L,(84.48±8.98)mmol/L vs.(103.62±10.31)mmol/L,(62.8±3.9)g/L vs.(66.3±1.7)g/L,(33.7±2.6)g/L vs.(36.7±l.8)g/L,(109.0±12.5)g/L vs.(132.0±5.2)g/L,all P<0.01].The amount of calcium of people in none long-term group was much lower [(1.57±0.23)mmol/L vs.(1.71±0.19)mmol/L,P<0.01].Ferrum,zinc,calcium and copper deficiencies

  6. Social relations as determinants of oral health among persons over the age of 80 years

    DEFF Research Database (Denmark)

    Avlund, Kirsten; Holm-Pedersen, Poul; Morse, Douglas E

    2003-01-01

    OBJECTIVE: To analyze whether social relations during a 7-year follow-up influence oral health among generally healthy, community-dwelling persons over the age of 80 years. METHOD: The present investigation is based on a subsample of 129 dentate community-dwelling individuals from The Kungsholmen......% CI: 1.2-7.2). CONCLUSION: This study suggests that social relations are related to the oral health status of old-old individuals. From a psychosocial perspective, our findings contribute to a deeper understanding of the background of oral health status in older adults....... Elders Oral Health Study (KEOHS), which included data from interviews and oral examinations. Social relations were measured in terms of marital status, living alone, frequency of contacts, number of confidants, and satisfaction with social contacts and with the frequency of contacts. Oral health...

  7. Nutritional risk screening and assessment in elderly patients aged over 80 years%80岁以上住院患者营养风险筛查与评估

    Institute of Scientific and Technical Information of China (English)

    刘海燕; 李虹; 唐海英; 李建中

    2016-01-01

    Objective To investigate the nutrition status of elderly patients aged more than 80 years by different assessment tools, and to compare the prevalence of malnutrition or nutritional risk among patients with different diseases. Methods 200 elderly patients aged over 80 years were enrolled in this study. Nutrition risk screening 2002(NRS2002), short-form mini-nutritional assessment( MNA-SF) and nutritional parameters such as body mass index( BMI) , albumin( Alb) , hemoglobin(Hb) were used to analyze the nutrition status of patients with different diseases. Consistency among the screening tools were measured by Kappa coefficient. Results Detected by NRS2002, 52. 50% of the participants were at risk of malnutrition. According to MNA-SF, the prevalence of malnutrition was 36. 50%, and 41. 00% of patients were at risk of malnutrition and 22. 50% of patients showed well nutrition. With the evaluation by BMI or Alb,the incidence of malnutrition was 10. 50%. 44. 50% of patients showed malnutrition if assessed by Hb only. Kappa testing showed that NRS2002 and MNA-SF were in moderate consistency( Kappa=0. 445) . The nutrition status assessed by BMI/Alb or Hb were poorly consistent to NRS2002(Kappa=0. 173 or 0. 264). Patients with cognitive dysfunction had higher risk of malnutrition and higher incidence rate of malnutrition than those without cognitive dysfunction. Conclusions The prevalence of malnutrition risk or malnutrition is high in patients aged more than 80 years, especially in those with cognitive dysfunction.%目的:运用多种评估方法对>80岁的高龄住院患者进行营养状况评估并进行比较,同时分析不同疾病状态的高龄患者存在营养风险或营养不良的情况。方法收集>80岁的高龄住院患者200例,采用营养风险筛查2002( NRS2002)、微型营养评价法( MNA-SF)以及传统营养状况评价指标包括体质量指数( BMI)、血清白蛋白( Alb)、血红蛋白( Hb)对其营养状况

  8. Dental caries in persons over the age of 80 living in Kungsholmen, Sweden: findings from the KEOHS project

    DEFF Research Database (Denmark)

    Morse, Douglas E; Holm-Pedersen, Poul; Holm-Pedersen, Jytte;

    2002-01-01

    The Kungsholmen Elders Oral Health Study (KEOHS) evaluated the oral health status of generally healthy, community-dwelling persons over the age of 80 living in Kungsholmen, an area in central Stockholm. This paper reports findings regarding the prevalence and severity of dental caries among...

  9. Food Intake of Kansans Over 80 Years of Age Attending Congregate Meal Sites

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    Allisha M. Weeden

    2010-12-01

    Full Text Available As the population of the United States continues to age, it has become increasingly more important to recognize the food intake and eating habits of older adults. The objective of this study was to describe the food group intake, factors predicting food group intake, and the food choices of community-dwelling Kansans, 80 years of age and older who participate in congregate meal programs. Participants completed a short questionnaire querying demographic information, current health status, and dietary supplement use. Participants (n = 113 were then followed up via telephone to complete two 24-hour diet recalls. Data were analyzed to determine adequacy of food group intake and mean intake. Regression analyses were used to determine factors predicting intake and frequency analysis established food typically consumed. Female participants were significantly more likely to consume more fruit servings than males. Intake was low for all five of the food groups, especially dairy. Chronic health conditions and dietary supplement use were consistently predictive factors of the amount of each food group consumed.

  10. [Is endovenous thrombolysis safety and efficacy in ischemic stroke comparable between patients aged over and above 80 years? Experience from an Argentinean cohort].

    Science.gov (United States)

    Colla-Machado, P E; Pigretti, S G; Luzzi, A A; Balian, N R; Cristiano, E; Zurru-Ganen, M C

    2017-04-16

    Introduccion. La inclusion de mayores de 80 años fue escasa en los estudios que evaluaron la terapia trombolitica. El objetivo de este estudio es comparar la seguridad y eficacia del uso de activador del plasminogeno tisular recombinante en pacientes mayores y menores de 80 años. Pacientes y metodos. Estudio prospectivo de pacientes que recibieron tratamiento trombolitico. Se comparo el tiempo de estancia, la incidencia de sangrado, la mortalidad hospitalaria y la evolucion a 90 dias en pacientes mayores y menores de 80 años. Resultados. De 1.996 pacientes con ictus ingresados entre octubre de 2005 y enero de 2016, 180 recibieron tratamiento trombolitico (9%). La edad media fue de 77 ± 10 años, con un 55% de mujeres. Cuando se compararon los menores y mayores de 80 años, en estos ultimos la estancia hospitalaria fue prolongada, con una mediana de 15 dias (rango intercuartilico: 6-19) frente a siete dias (rango intercuartilico: 4-12; p = 0,001), y la discapacidad a los tres meses fue mayor (escala de Rankin 0-1 del 24% frente al 41%; p = 0,001). La puntuacion ASPECTS de ingreso, la incidencia de sangrado y la mortalidad hospitalaria no mostraron diferencias entre mayores y menores de 80 años. Los pacientes mayores de 80 años tuvieron menor tiempo de demora para llegar al hospital (97 ± 34 frente a 113 ± 45 min; p = 0,01); sin embargo, el tiempo puerta-aguja fue superior en los mayores de 80 años. Conclusion. La terapia trombolitica en los mayores de 80 años fue segura, aunque el grado de beneficio para reducir la discapacidad resulto menor.

  11. To screen or not to screen for peripheral arterial disease in subjects aged 80 and over in primary health care: a cross-sectional analysis from the BELFRAIL study

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    Degryse Jan

    2011-05-01

    Full Text Available Abstract Background Peripheral arterial disease (PAD is common in older people. An ankle-brachial index (ABI Methods A cross-sectional study embedded within the BELFRAIL study. A general practitioner (GP centre, located in Hoeilaart, Belgium, recruited 239 patients aged 80 or older. Only three criteria for exclusion were used: urgent medical need, palliative situation and known serious dementia. The GP recorded the medical history and performed a clinical examination. The clinical research assistant performed an extensive examination including Mini-Mental State Examination (MMSE, Geriatric Depression Scale (GDS-15, Activities of Daily Living (ADL, Tinetti test and the LASA Physical Activity Questionnaire (LAPAQ. ABI was measured using an automatic oscillometric appliance. Results In 40% of patients, a reduced ABI was found. Cardiovascular risk factors were unable to identify patients with low ABI. A negative correlation was found between the number of cardiovascular morbidities and ABI. Cardiovascular morbidity had a sensitivity of 65.7% (95% CI 53.4-76.7 and a specificity of 48.6% (95% CI 38.7-58.5. Palpation of the peripheral arteries showed the highest negative predictive value (77.7% (95% CI 71.8-82.9. The LAPAQ score was significantly lower in the group with reduced ABI. Conclusion The prevalence of PAD is very high in patients aged 80 and over in general practice. The clinical examination, cardiovascular risk factors and the presence of cardiovascular morbidity were not able to identify patients with a low ABI. A screening strategy for PAD by determining ABI could be considered if effective interventions for those aged 80 and over with a low ABI become available through future research.

  12. The strength of two indicators of social position on oral health among persons over the age of 80 years

    DEFF Research Database (Denmark)

    Avlund, Kirsten; Holm-Pedersen, Poul; Morse, Douglas E;

    2005-01-01

    OBJECTIVE: The objective of the present study is to analyze how two dimensions of social position, education and social class, are associated with oral health among generally healthy, community-dwelling persons over the age of 80 years. METHODS: The present investigation is based on a sample of 157...... community-dwelling individuals from The Kungsholmen Elders Oral Health Study (KEOHS) and included data from interviews and oral examinations. Social position was measured by education and social class. Oral health was measured by active coronal caries, active root caries, edentulism and use of dental...... of being edentulous. Further, persons with elementary/ medium education tended to forego regular dental services more than persons with high education. CONCLUSION: The study identified social inequalities in oral health even in a population of independently living, generally healthy very old Swedes...

  13. 高龄老人虚弱指数的个体和区域影响因素分析%Analysis on the Individual and Environmental Determinants of Frailty Index among Chi-nese Old People Aged Over 80

    Institute of Scientific and Technical Information of China (English)

    潘国英; 陈鹤; 张拓红

    2015-01-01

    目的:分析高龄老人虚弱指数的个体和区域影响因素.方法利用中国老年健康影响因素跟踪调查(CLHLS)2011年横断面数据,对其中80岁及以上的高龄老人计算虚弱指数,通过统计描述和分层线性模型,分析其个体和区域影响因素.结果高龄、女性、非独居、城镇居住、经济自评差、社会参与度低、健康食品摄入不足的高龄老人虚弱指数高.低气温、高工业废气与个体因素有交互作用,总体上工业废气排放越高,平均气温越低,则虚弱指数越高,并且这两项因素在最终模型中可以解释虚弱指数区域差别的54.8%(残差方差比例),模型可靠性为0.832.结论高龄老人虚弱指数可能受到个体和区域等多因素影响.%Objectives To analyze the individual and environmental factors of frailty index of the old people aged 80 years and over.Methods Calculating frailty index of the old people aged 80 years and over and participated Chi-nese Longitudinal Healthy Longevity Survey 201 1.Statistical description and Hierarchical Linear Model were used to analyze the individual and regional factors.Results Frailty index will be higher for those who are in advanced age, female,not living alone,urban residents,low economic self-assessment,low social participation level,low health food intake,low temperature and high industrial waste gas emission.The two environmental factors explained 54.8% of regional residual variance and the reliability of the model is 0.832.Conclusions Frailty index of Chinese oldest old shows significant relationship with individual factors and the environmental factors.

  14. Reliability of treating asymptomatic traumatic type II dens fractures in patients over age 80: A retrospective series

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    Eric Momin

    2015-01-01

    Full Text Available Background: Management of type II odontoid fractures in elderly remains controversial to whether surgical treatment is favored over conservative one. This is a study of geriatric patients with asymptomatic type II dens fractures who after sustaining a fall were initially evaluated at community hospitals. They were placed in a rigid collar and were followed up in a spine clinic. Purpose: To assess the reliability of treating very old patients with type II dens fracture conservatively and whether surgical intervention if needed would affect the clinical outcome. Study Design: Retrospective study with the literature review. Patient Sample: Consecutive patients above 80 years of age, who sustained a clinically asymptomatic type II dens fracture and were observed after a conservative treatment plan, was initiated. Outcome Measures: Outcome measures included self-reported worsening neck pain, neurological function, and radiographic measures over the follow-up period. Materials and Methods: A retrospective clinical analysis of 5 active geriatric patients with type II asymptomatic dens fracture. After evaluating them, treatment options were discussed with patients and their family members. The decision was to continue to follow them with a rigid collar very closely since they were reluctant to undergo any surgical procedure. Results: Patients were followed for an average of 29 months. They were observed for any worsening neck pain, neurological deficit, or deterioration of fracture on follow-up imaging studies. At last follow-up, 2 of 5 patients continued to be asymptomatic, the 3 rd died of unrelated causes while 2 others required surgeries at least 1-year post injury. Conclusions: Treatment of type II dens fractures in the elderly is controversial. Independent elderly patients who are asymptomatic at presentation may be safe to be followed up very closely with a neck brace and serial X-ray. Converting to surgical treatment can be done safely when

  15. 80 Gb/s transmission over 80 km and demultiplexing using a highly non-linear photonic crystal fibre

    DEFF Research Database (Denmark)

    Berg, Kim Skaalum; Oxenløwe, Leif Katsuo; Siahlo, Andrei;

    2002-01-01

    We report on, transmission of an 80 Gb/s signal over 80 km of standard single mode fibre with subsequent demultiplexing to 10 Gb/s in a NOLM containing a novel photonic crystal fibre......We report on, transmission of an 80 Gb/s signal over 80 km of standard single mode fibre with subsequent demultiplexing to 10 Gb/s in a NOLM containing a novel photonic crystal fibre...

  16. HIV Among People Aged 50 and Over

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    ... Prevention VIH En Español Get Tested Find an HIV testing site near you. Enter ZIP code or city Follow HIV/AIDS CDC HIV CDC HIV/AIDS See RSS | ... Email Updates on HIV Syndicated Content Website Feedback HIV Among People Aged 50 and Over Language: English ...

  17. Association of isokinetic strength with pain and functional status in knee osteoarthritis patients aged 80 years and over%80岁及以上膝骨性关节炎患者等速肌力与疼痛和功能状态的关系

    Institute of Scientific and Technical Information of China (English)

    瓮长水; 郭燕梅; 陈蔚; 黎春华; 王娜

    2014-01-01

    目的 评估80岁及以上膝骨性关节炎(OA)患者膝关节等速肌力与疼痛和功能状态之间的关系. 方法 32例膝OA患者和10例健康受试者作为对照组.对膝OA患者进行视觉模拟评分法(VAS)疼痛强度评分、Lequesne指数.对膝OA组和对照组受试者进行膝关节伸肌和屈肌标准化等速向心收缩测试程序,角速度为60°/s和180°/s,进行功能性移动能力测试:5次坐到站测试(FTSST)、3 m计时起立行走测试(TUGT)和10m计时步行测试(TWT). 结果 膝OA组与对照组受试者在两个角速度的伸肌和屈肌的相对峰力矩之间的比较差异有统计学意义(t=2.747,P<0.05).伸肌相对峰力矩与年龄、Liquesce指数总分、FTSST、TUGT和TWT之间呈负相关(r=-0.39~-0.75,均P<0.05).伸肌相对峰力矩与VAS得分和Lequesne指数疼痛评分之间无相关(r=-0.23~ 0.31,均P>0.05).伸肌相对峰力矩和VAS得分两者是Liquesce指数的重要预测因子,可解释Liquesce指数41%的变异量(adjusted R2=0.41). 结论 80岁及以上膝OA患者肌力损害程度与其功能表现密切关联,股四头肌肌力和疼痛强度是预测失能的重要指标.%Objective To evaluate the difference in isokinetic strength of the knee muscles between knee osteoarthritis (KOA) patients aged 80 years and over and matched healthy controls,and to establish the association of isokinetic strength with pain and functional status in patients with KOA.Methods The study enrolled 32 patients aged 80 and over diagnosed with unilateral knee OA and 10 matched controls.Pain was evaluated by the visual analogue scale (VAS),the pain intensity scale and the Lequesne index for patients with knee OA.Functional status was assessed by the Timed Up and Go Test (TUGT),the Five Times Sit to Stand Test (FTSST) and the Timed 10 Meter Walk Test (TWT).Muscle strength was measured using the isokinetic dynamometer Biodex System 4 Pro.Bilateral isokinetic (concentric) knee flexion and extension with

  18. Clinical features and treatment outcome of very elderly patients over 80 years old with multiple myeloma: comparison with patients in different age groups in the era of novel agents.

    Science.gov (United States)

    Matsue, Kosei; Matsue, Yuya; Fujisawa, Manabu; Fukumoto, Kota; Suehara, Yasuhito; Sugihara, Hiroki; Takeuchi, Masami

    2016-01-01

    We retrospectively analyzed the outcomes of 175 consecutive patients admitted to our hospital between April 2004 and June 2014, and identified 42 (24%), 80 (46%), and 53 (30%) patients ≥ 80, 66-79, and ≤ 65 years old, respectively. The median progression-free survival (PFS) and overall survival (OS) of the ≥ 80, 66-79, and ≤ 65 years old groups were 19.1, 26.3, and 54.3 months, and 31.9, 54.8, and 83.8 months, respectively. Patients ≥ 80 but not ≤ 79 years old with ECOG performance score (PS) ≥ 3 and/or Charlson comorbidity index (CCI) ≥ 5 showed significantly shorter survival. ECOG PS and CCI predicted the treatment outcome of patients ≥ 80 but did not predict ≤ 79 years old.

  19. Risk factors analysis of white matter lesions of different degrees in the elderly aged 80 years and over%高龄老年人不同程度脑白质损害的危险因素分析

    Institute of Scientific and Technical Information of China (English)

    王月菊; 侯宝元; 董凌燕; 李虹; 李建中

    2011-01-01

    Objective To investigate the independent risk factors of cerebral white matter lesions (WML) of different degrees in the elderly aged 80 years and over,and provide the evidences for forecasting the prognosis of WML.Methods Brain magnetic resonance images (MRI) findings in 151 people aged 74 to 93 years were collected and analyzed.According to the severity of WML in brain MRI using the Fazekas Scale,the persons were divided into non-WML (control) group,mildWML (grade 1 WML) group and moderate-to-severe WML (grade 2 WML) group.The cognitive score,vascular risk factors,cerebral hemodynamic and arteriosclerotic index,and radiological features were compared among the three groups.Subsequent one-way ANOVA and multivariate logistic analysis were performed to determine the statistically significant factors and the independent risk factors among groups.Results The statistically significant factors with one-way ANOVA analysis among the three groups were cognitive performance (F = 48.595,P = 0.000),hypertension (x2 =7.052,P=0.029),cigarette history (x2 = 19.476,P= 0.000),cholesterol (TC) (F= 3.086,P=0.049),Crouse score (F=3.968,P=0.021) and multiple cerebral atrophy indexes.When compared with control group,cigarette history (OR 2.031,95%CI 1.244-1.317),lacunar infarction (LI)numbers (OR 2.031,95%CI 1.316-4.015) and cholesterol (OR 1.610,95%CI 0.972-2.668) were independent risk factors in grade 1 WML group (all P<0.05).The independent risk factors between grade 1 and 2 WML group were cognitive performance (OR 0.276,95%CI 0.143-0.532),cigarette history (OR 2.262,95% CI 1.260-4.059),and sylvian fissure ratio (SFR) (OR 1.954,95% CI 1.013-3.768) (all P<0.05).The independent risk factors between the grade 2 WML group and control group were cognitive performance (OR 0.091,95%CI 0.030-0.273),bicoudate ratio (BCR)(OR 2.511,95%CI 1.147-5.499),Crouse score (OR 2.304,95%CI1.127-4.712)and LI numbers (OR 2.200,95%CI 1.028-4.707) (all P<0.05).Conclusions Mild WML patients have no

  20. Activity participation and cognitive aging from age 50 to 80 in the glostrup 1914 cohort

    DEFF Research Database (Denmark)

    Gow, Alan J; Mortensen, Erik L; Avlund, Kirsten

    2012-01-01

    To examine the cognitively protective effect of leisure and physical activities while accounting for prior cognitive ability, a rarely considered confounder of the previously reported associations between activity and cognitive aging.......To examine the cognitively protective effect of leisure and physical activities while accounting for prior cognitive ability, a rarely considered confounder of the previously reported associations between activity and cognitive aging....

  1. Osteoarticular diseases and physical performance of Brazilians over 80 years old

    Directory of Open Access Journals (Sweden)

    Vanessa Ribeiro dos Santos

    2016-02-01

    Full Text Available Abstract Objective To investigate the physical performance of Brazilian individuals older than 80 years with and without OD. Methods The sample consisted of 135 individuals (aged > 80 years of both gender. Identification of osteopenia/osteoporosis was verified by Dual Energy X-ray Absorptiometry, and the presence of others osteoarticular diseases (OD was obtained using a questionnaire of morbidities. Physical performance was analyzed by motor tests. Results Men presented higher proportion of osteopenia/osteoporosis compared to women (p = 0.013. The proportion of older people with arthritis/osteoarthritis for women and men was 33% and 26%, respectively, and with OD in the spine was 19% and 12%, respectively. No significant difference for physical performance, measured by each test and overall score, was observed between groups of OD. According to gender, male with OD presented lower performance in gait speed, balance and overall score (p < 0.05, while older people with osteopenia/osteoporosis are at higher risk for low physical performance (OR 2.73; CI 95% 1.31-5.66. Conclusion In conclusion it was verified in older people with age of 80 years or more, a high prevalence of OD, especially in men, and the presence of these diseases interfered negatively their physical performance.

  2. Does white coat hypertension require treatment over age 80?: Results of the hypertension in the very elderly trial ambulatory blood pressure side project.

    Science.gov (United States)

    Bulpitt, Christopher J; Beckett, Nigel; Peters, Ruth; Staessen, Jan A; Wang, Ji-Guang; Comsa, Marius; Fagard, Robert H; Dumitrascu, Dan; Gergova, Vesselka; Antikainen, Riitta L; Cheek, Elizabeth; Rajkumar, Chakravarthi

    2013-01-01

    White coat hypertension is considered to be a benign condition that does not require antihypertensive treatment. Ambulatory blood pressure (ABP) was measured in 284 participants in the Hypertension in the Very Elderly Trial (HYVET), a double-blind randomized trial of indapamide sustained release 1.5 mg±perindopril 2 to 4 mg versus matching placebo in hypertensive subjects (systolic blood pressure 160-199 mm Hg) aged >80 years. ABP recordings (Diasys Integra II) were obtained in 112 participants at baseline and 186 after an average follow-up of 13 months. At baseline, clinic blood pressure (CBP) exceeded the morning ABP by 32/10 mm Hg. Fifty percent of participants fulfilled the established criteria for white coat hypertension. The highest ABP readings were in the morning (average 140/80 mm Hg), the average night-time pressure was low at 124/72 mm Hg, and the average 24-hour blood pressure was 133/77 mm Hg. During follow-up, the systolic/diastolic blood pressure placebo-active differences averaged 6/5 mm Hg for morning ABP, 8/5 mm Hg for 24-hour ABP, and 13/5 mm Hg for CBP. The lowering of blood pressure over 24 hours supports the reduction in blood pressure with indapamide sustained release±perindopril as the explanation for the reduction in total mortality and cardiovascular events observed in the main HYVET study. Because we estimate that 50% had white coat hypertension in the main study, this condition may benefit from treatment in the very elderly.

  3. Functional ability and oral health among older people: a longitudinal study from age 75 to 80

    DEFF Research Database (Denmark)

    Avlund, K; Holm-Pedersen, P; Schroll, M

    2001-01-01

    -sectional studies of 75- and 80-year-old people included 411 and 321 persons, respectively. The longitudinal study from age 75 to 80 included the 326 persons who participated in both surveys. MEASUREMENTS: Oral health status was measured roughly by number of teeth and chewing ability. Use of dental services...... was measured by frequency of visits to a dentist or denturist. Functional ability was measured by two scales on mobility in relation to tiredness and need of help. Changes in mobility from age 75 to 80 is described as (1) improved or sustained good, (2) decreased, and (3) sustained poor. Gender, chronic...... diseases, self-rated health, socio-demographic factors, living alone, and social relations were included as possible confounders. RESULTS: The odds ratio of having no or few teeth was 1.7 (1.1-2.6) in 75-year-old individuals who felt tired in mobility, 1.7 (1.0-2.9) in 80-year-old persons who needed help...

  4. 80岁以上慢性心力衰竭患者的综合治疗%The comprehensive therapy for patients aged over 80 years old with chronic heart failure

    Institute of Scientific and Technical Information of China (English)

    黄带发; 贺顺川; 王聿杰; 刘艳霞; 于伟

    2012-01-01

    Objective: To explore the efficacy of comprehensive therapy combined with drug therapy and psychotherapy in patients aged over 80 years with chronic heart failure ( CHF). Methods: Between January 2006 and August 2011, from 52 CHF patients aged over 80 years registered in General Hospital of Shenyang Military Command, 36 patients without physical activity disability were included in this study and divided into sport rehabilitation and control groups (re = 18, each). For control group, the drug therapy and psychotherapy were given based on which exercise rehabilitation was added in sport rehabilitation group. The heart function, psychological state and survival state were compared between the two groups at 3 months after treatment. Results: (1) The BNP value was deceased in both sport rehabilitation and control groups. Nevertheless, no difference was found in BNP value between the two groups ( P > 0. 05 ). The patients with NYHA Class I of heart function were 16 cases and 11 cases in sport rehabilitation and control groups, respectively. However, there was no difference between the two groups (Χ2 =2. 370, P =0. 124). (2)Both 6MWT walking distance and MLHFQ scoring in sport rehabilitation group were better than those in control group ( P 0. 05). (4) By February 2012, 38 patients still survived among a total of 52 patients. Notably, 3 cases were found with more than 5 years of disease period. The remaining 14 dead patients were all long-term bed patients. For sport rehabilitation group, the hospitalization time and times were relatively less as compared with control group (P<0.05). Conclusion: Drug therapy combined with exercise rehabilitation and psychotherapy could improve the heart function and survival quality and shorten the hospitalization time and times. Nevertheless, the further observation was still required in the following-up.%目的:探讨药物结合运动、心理康复治疗的综合方案对80岁以上心力衰竭患者的效果.方法:选择2006年1

  5. 白细胞计数、中性粒细胞百分比、降钙素原和C反应蛋白在80岁以上老年感染性患者中的应用评价%Application value of white blood cell,neutrophil percentage,procalcitonin and C-reactive protein in patients aged 80 and over with infectious diseases

    Institute of Scientific and Technical Information of China (English)

    王婷; 刘振国; 柴春艳; 徐邦强

    2016-01-01

    Objective To evaluate the clinical value of white blood cell count( WBC) , neutrophil percentage( N) , procalcitonin(PCT)and C⁃reactive protein(CRP) for infectious diseases in the patients aged 80 and over. Methods The clinical data of 84 patients aged 80 and over with infectious diseases in our department from January 2013 to December 2014 were observed retrospectively. Results Pulmonary infection was the most common infectious disease in elderly pa⁃tients. Among all the examples, acute exacerbation of chronic obstructive pulmonary disease ( AECOPD) accounted for 59. 5% (50 cases), followed by bacterial pneumonia (33. 3%, 28 cases), aspergillus pneumonia (2. 4%, 2 cases), pressure ulcers complicated with infection ( 2. 4%,2 cases) , acute suppurative inflammation of bladder ( 2. 4%,2 cases) respetctively. WBC and N were sensitive to bacterial infection, which were influenced by the body��s immune status, accom⁃panying diseases and used drug. CRP showed a high sensitivity but low specificity to infection. The level of PCT was not in⁃creased in mild infections and localized bacterial infections, which showed low sensibility to AECOPD and mild bacterial pneumonia. Conclusions WBC,N,PCT,CRP all have limitations for elderly patients with infectious diseases, combined detection may be helpful.%目的探讨外周血白细胞计数( WBC)、中性粒细胞百分比( N)、降钙素原( PCT)及C反应蛋白( CRP )水平在≥80岁老年感染性疾病患者中的评估价值。方法对我科2013年1月至2014年12月84例≥80岁老年感染性疾病住院患者进行回顾性分析,对临床资料及实验室检测指标进行分析。结果老年感染性疾病以肺部感染为主,其中慢性阻塞性肺疾病急性加重期(AECOPD)50例(59.5%),细菌性肺炎28例(33.3%),曲霉菌肺炎2例(2.4%);褥疮并感染2例(2.4%),急性化脓性膀胱炎2例(2.4%)。 WBC与N对细菌性感染

  6. Influence of aging modes on microstructure and mechanical properties of AZ80 magnesium alloy

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The microstructure and mechanical properties of AZ80 magnesium alloy after solid solution and aging treatments were studied by using optical microscope (OM), X-ray diffraction (XRD), scanning electron microscopy(SEM) as well as tensile testing. The results indicated that β-Mg17Al12 phase was getting to distribute discontinuously along the grain boundary after treated at 395℃ ageing for 12 h followed by water-cooling, but it did not dissolve into α-Mg completely. The residual β-Mg17Al12 phase distributed along the grain boundary and had block-like or island shapes. The size of α-Mg was getting to be coarsening but not significantly. The β-Mg17Al12 precipitates appeared in discontinuous and continuous patterns from supersaturated α-Mg solid solution after aged at 200℃. The precipitation patterns were associated with the aging time essentially. The tensile strength and elongation of the alloy increased significantly but the hardness and yield strength decreased after solid solution treatment. However, with the prolonging of aging time, the hardness and strength of alloy increased while the ductility decreased.

  7. An in-situ neutron diffraction study of the ageing of CaNi5Dx at 80ºC and 9 bar

    DEFF Research Database (Denmark)

    Pitt, M.P.; Brinks, H.W.; Jensen, Jens Oluf;

    2004-01-01

    The intrinsic ageing of the CaNi5Dx system has been studied at 80 ◦C and 9 bar over a period of 13 days. The system displays a distinct two-phase mixture of the intermediate and phases, whose phase proportions approach 40 and 50 wt.%, respectively at the end of the ageing period. The change in pr...

  8. 护士主导全科团队服务对高龄独居老人心理干预的效果评价%Effects of a nurse-led multidisciplinary team intervention program for elderly aged over 80 and Hying alone at home

    Institute of Scientific and Technical Information of China (English)

    荀雪琴; 易景娜; 刘清; 曹缨; 汪友斌; 乐嘉宜

    2011-01-01

    目的 评价以社区护士为主导的全科团队服务对社区高龄独居老人抑郁、孤独等心理状况的影响.方法 将81例80岁以上的高龄独居老人随机分为干预组41例和对照组40例,干预组接受为期3个月、每月3次、每次30min,由社区护士为主导的高龄独居老人全科团队家访服务.对照组实施常规的社区卫生服务.两组在干预前后分别进行抑郁、孤独等观察指标评价.结果 干预前两组高龄老人抑郁、孤独显著低于我国常模水平(p<0.05),两组间差异无统计学意义.干预后干预组抑郁、孤独得分均低于干预前水平和对照组同期水平(P<0.01),对照组前后变化不明显(P=0.858和0.785).结论 以社区护士为主导的全科团队家访服务可明显改善高龄独居老人的抑郁、孤独等不良心理状况.%Objective To evaluate the effect of a nurse-led multidisciplinary team intervention program on the psychological state such as depression and loneliness in community-dwelling elderly aged over 80 who lived alone. Methods Eighty-one elderly people aged over 80 who lived alone were randomly divided into two groups. The 41 elderly in the intervention group received a nurse-led multidisciplinary team home visit program, for three months and were visited three times a month. The 40 elderly in the control group received usual community health care. All the elderly were investigated with Geriatric Depression Scale(GDS) and UCLA Loneliness Scale before and after the intervention. Results Before the intervention,the scores of depression and loneliness were both higher than the norms (P0.05). After the intervention,the scores of depression and loneliness were significantly decreased in the intervention group, and were significanlty lower than the control group (P0.05). Conclusion The nurse-led multidisciplinary team intervention program can relieve the depression and loneliness of elderly aged over 80 who lived alone in community.

  9. Total shoulder replacement for osteoarthritis in patients 80 years of age and older.

    Science.gov (United States)

    Foruria, A M; Sperling, J W; Ankem, H K; Oh, L S; Cofield, R H

    2010-07-01

    This study was performed to review the safety and outcome of total shoulder replacements in patients who are > or = 80 years of age. A total of 50 total shoulder replacements in 44 patients at a mean age of 82 years (80 to 89) were studied. Their health and shoulder status, the operation and post-operative course were analysed, including pain, movement, patient satisfaction, medical and surgical complications, radiographs, the need for revision surgery, and implant and patient survival. A total of 27 patients had an ASA classification of III or IV and medical abnormalities were common. Of the 13 shoulders with bony deficiency of the glenoid, nine required grafting. The duration of hospital stay was prolonged and blood transfusions were common. There were no peri-operative deaths. The mean follow-up was for 5.5 years (2 to 12). Pain was significantly reduced (p shoulders had an excellent or satisfactory result. There were medical or surgical complications in 17 cases. Four shoulders developed radiological evidence of loosened glenoid components, and three of these had a poor outcome. Three other shoulders required revision, two for instability. By the time of this review 39 of the patients had died from unrelated causes at a mean of 7.5 years (0.8 to 16.4) after surgery. Total shoulder replacement is a relatively effective treatment in this elderly group of patients. However, there is a requirement for more intense patient care in the peri-operative period, and non-fatal medical or surgical complications are common. Most of these elderly patients will have a comfortable functional shoulder for the rest of their lives.

  10. Sex differences in cognition are stable over a 10-year period in adulthood and old age.

    Science.gov (United States)

    de Frias, Cindy M; Nilsson, Lars-Göran; Herlitz, Agneta

    2006-01-01

    Sex differences in declarative memory and visuospatial ability are robust in cross-sectional studies. The present longitudinal study examined whether sex differences in cognition were present over a 10-year period, and whether age modified the magnitude of sex differences. Tests assessing episodic and semantic memory, and visuospatial ability were administered to 625 nondemented adults (initially aged 35-80 years), participating in the population-based Betula study at two follow-up occasions. There was stability of sex differences across five age groups and over a 10-year period. Women performed at a higher level than men on episodic recall, face and verbal recognition, and semantic fluency, whereas men performed better than women on a task-assessing, visuospatial ability. Sex differences in cognitive functions are stable over a 10-year period and from 35 to 90 years of age.

  11. Hospital mortality of patients aged 80 and older after surgical repair for type A acute aortic dissection in Japan

    Science.gov (United States)

    Ohnuma, Tetsu; Shinjo, Daisuke; Fushimi, Kiyohide

    2016-01-01

    Abstract To evaluate whether patients aged 80 and older have higher risk of hospital mortality after repair of type A acute aortic dissection (TAAAD). Emergency surgery for TAAAD in patients aged 80 and older remains a controversial issue because of its high surgical risk. Data from patients who underwent surgical repair of TAAAD between April 2011 and March 2013 were retrospectively extracted from the Japanese Diagnosis Procedure Combination database. The effect of age on hospital mortality was evaluated using multivariate logistic regression analysis. A total of 5175 patients were enrolled. The mean age of patients was 67.1 ± 13.0 years, and the male:female ratio was 51:49. Patients aged 80 and older more frequently received tracheostomy than their younger counterparts (9.5% vs 5.4%, P <0.001). Intensive care unit and hospital stays were significantly longer in the elderly cohort versus the younger cohort (7.6 vs 6.7 days, P <0.001, and 42.2 vs 35.8 days, P <0.001, respectively). Logistic regression analysis showed that age80 years was significantly associated with a higher risk of hospital mortality (adjusted odds ratio, 1.62; 95% confidence interval, 1.28–2.06; P <0.001). In linear regression analysis, age80 years was also significantly associated with longer hospital stay (P = 0.007). In a large, nationwide, Japanese database, patients aged 80 and older were at increased risk of hospital mortality and length of hospital stay. PMID:27495057

  12. Percutaneous nephrolithotomy in very elderly patients (Age 75 and Over

    Directory of Open Access Journals (Sweden)

    Hüseyin Çelik

    2015-12-01

    Full Text Available Objective: Percutaneous nephrolithotomy (PNL is a minimally invasive method used safely in surgical treatment of kidney stones in the world. The first PNL surgery performed in our clinic in March 1998 and first PNL surgery was performed in June 2000 over the age of seventy which was bilaterally side. In our study, PNL operations performed for 75 years and older patients were examined. Methods: PNL operations were performed under the general anesthesia. After cystoscopy in the supine position, ureteral catheter was inserted accompanied by C-arm fluoroscopy. Afterwards, patients were taken prone position then we entered into the kidney with a metal needle with fluoroscopic on. We dilated the entrance with Amplatzer renal dilatators set until the 30 F. After the procedure, the nephrostomy catheter was placed in the renal sheath. 4 mm residual fragments after the PNL operation were accepted as clinically insignificant stone residues (CIRF. Results: 3003 PNL procedures were performed between dates March 1998 - December 2014 in total 16 years. 28 patients of total were 75 years and over. 29 PNL surgeries performed to these patients, including one bilateral PNL procedure. Mean age was 79.36 years (75-88. Twenty (74% of the patients were concluded stone free. 2 patients had tubeless PNL surgery. There was no another complication. Conclusion: PNL is a minimally invasive method has became advantageous according to open surgery because of higher safety, lower complication rates, shorter hospitalization stay, more patient comfort and higher stone free rates. PNL is a safe and effective method in the surgical treatment of urinary tract stone diseases.

  13. Constant mortality and fertility over age in Hydra

    DEFF Research Database (Denmark)

    Schaible, R.; Scheuerlein, A.; Danko, M. J.

    2015-01-01

    Senescence, the increase in mortality and decline in fertility with age after maturity, was thought to be inevitable for all multicellular species capable of repeated breeding. Recent theoretical advances and compilations of data suggest that mortality and fertility trajectories can go up or down......, or remain constant with age, but the data are scanty and problematic. Here, we present compelling evidence for constant age-specific death and reproduction rates in Hydra, a basal metazoan, in a set of experiments comprising more than 3.9 million days of observations of individual Hydra. Our data show...... that 2,256 Hydra from two closely related species in two laboratories in 12 cohorts, with cohort age ranging from 0 to more than 41 y, have extremely low, constant rates of mortality. Fertility rates for Hydra did not systematically decline with advancing age. This falsifies the universality...

  14. Nutrition study people over 80 years

    Directory of Open Access Journals (Sweden)

    Javier Benítez

    2012-12-01

    Full Text Available La soledad siempre se ha asociado como factor de riesgo en la vejez. La población de personas mayores de 80 años que viven solas son el objetivo de estudio para determinar su situación y potencial para poder mejorar su calidad de vida. Objetivos: Determinar el estatus nutricional de la población mayor de 80 años que vive sola en el área de “La Laguna” en Cádiz. Material y métodos: El programa PIAMLA’80 analiza estos parámetros y sus posibles correlaciones en un grupo de 342 sujetos. Se han medido diferentes valores como test de Barthel, Lawton-Brody, Lobo, Gijón, MNA y valores bioquímicos sanguíneos. Resultados: En una población de 984 sujetos, fueron seleccionados inicialmente 342, pero finalmente el grupo disminuyó a 247. La media de Barthel fue de 80,42 puntos, 5,76 para el Lawton, 11,3 para Gijón y 26,48 para Lobo. El MNA para la población total fue de 24,25/30, detectando solo un grupo de riesgo en mujeres de 85 a 95 años. La correlación entre nutrición y parámetros analíticos fue positiva para Hemoglobina (0,19, proteínas totales (0,26, Hierro (0,32 y albúmina (0,46. Conclusiones: En nuestro estudio no hemos detectado malnutrición en ningún rango de edad ni género. El uso del test MNA debe generalizarse como rápido, fácil y efectivo.

  15. Prevalence and risk factors of atrial fibrillation in preterminal inpatients aged 60 years and over

    Institute of Scientific and Technical Information of China (English)

    YANG Jie-fu; LIU Bing; LIU Dong-ge; LUO Yao; FANG Fang

    2008-01-01

    Background Atrial fibrillation is a common arrhythmia and a major risk factor for ischaemic stroke. We investigated the prevalence of atrial fibrillation and its relation to age, gender and underlying heart disease in patients aged 60 years and over who died during hospitalization.Methods Between 1955 and 2005, 1519 autopsies of in-hospital deaths in Beijing Hospital were performed. Among them, 540 cases met criteria of age ≥60 years and full clinical history including electrocardiogram, echocardiogram, myocardial perfusion images and detailed cardiac pathology records from autopsy.Results Atrial fibrillation occurred in 193 of 540 patients and prevalence increased with age (10.5% in patients younger than 60 years, 39.6% (80-89 years) and 54.8% (≥90 years)) being higher in patients with underlying heart disease than without heart disease (P<0.0001). Coronary artery disease (CAD), congestive heart failure, cardiac valve dysfunction and chronic renal failure were associated with a higher prevalence of atrial fibrillation (P<0.001). CAD with anterior myocardial infarction or left anterior descending artery disease was also associated with an increased prevalence of atrial fibrillation (P <0.05). Following autopsy, clinical misdiagnosis of CAD increased with age and missed clinical diagnosis of CAD decreased with age. Multivariate Logistic regression analysis revealed independent predictors of atrial fibrillation: age (OR=1.335, 95% Cl: 1.114-1.600, P<0.0001), underlying heart disease (OR=2.019, 95% CI: 1.244-3.278, P <0.005), chronic heart failure (OR=1.873, 95% CI: 1.272-2.757, P <0.005), mitral regurgitation (OR=2.163, 95% Cl: 1.093-4.278, P<0.05) and mitral stenosis (OR=33.575, 95% CI: 2.852-395.357, P<0.05). Conclusions A high prevalence of atrial fibrillation was found in Chinese patients

  16. Outcome of patients over 80 years of age on prolonged suppressive antibiotic therapy for at least 6 months for prosthetic joint infection

    Directory of Open Access Journals (Sweden)

    Virginie Prendki

    2014-12-01

    Conclusions: Prolonged suppressive antibiotic therapy is an alternative therapy in elderly patients with PJI when surgery is contraindicated and when the bacteria are susceptible to well-tolerated oral antimicrobial therapy such as beta-lactams.

  17. Randomized Polypill crossover trial in people aged 50 and over.

    Directory of Open Access Journals (Sweden)

    David S Wald

    Full Text Available BACKGROUND: A Polypill is proposed for the primary prevention of cardiovascular disease in people judged to be at risk on account of their age alone. Its efficacy in reducing cholesterol and blood pressure is uncertain. METHODS: We conducted a randomized double-blind placebo-controlled crossover trial of a Polypill among individuals aged 50+ without a history of cardiovascular disease and compared the reductions with those predicted from published estimates of the effects of the individual drugs. Participants took the Polypill (amlodipine 2.5 mg, losartan 25 mg, hydrochlorothiazide 12.5 mg and simvastatin 40 mg each evening for 12 weeks and a placebo each evening for 12 weeks in random sequence. The mean within-person differences in blood pressure and low density lipoprotein (LDL cholesterol at the end of each 12 week period were determined. RESULTS: 84 out of 86 participants completed both treatment periods. The mean systolic blood pressure was reduced by 17.9 mmHg (95% CI, 15.7-20.1 on the Polypill, diastolic blood pressure by 9.8 mmHg (8.1-11.5, and LDL cholesterol by 1.4 mmol/L (1.2-1.6, reductions of 12%, 11%, and 39% respectively. The results were almost identical to those predicted; 18.4 mmHg, 9.7 mmHg, and 1.4 mmol/L respectively. CONCLUSION: The Polypill resulted in the predicted reductions in blood pressure and LDL cholesterol. Long term reductions of this magnitude would have a substantial effect in preventing heart attacks and strokes. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN36672232.

  18. Electric charge fluctuations in central Pb+Pb collisions at 20, 30, 40, 80 and 158 AGeV

    CERN Document Server

    Anticic, T; Barna, D; Bartke, Jerzy; Behler, M; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Darmenov, N; Dimitrov, A; Dinkelaker, P; Eckardt, V; Filip, P; Flierl, D; Fodor, Z; Foka, P; Freund, P; Friese, V; Gál, J; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Grebieszkow, K; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kliemant, M; Kniege, S; Kolesnikov, V I; Kollegger, T; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Van Leeuwen, M; Lévai, Peter; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Markert, C; Mateev, M; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Pálla, G; Panagiotou, A D; Panayotov, D; Petridis, A; Pikna, M; Pinsky, L; Pühlhofer, F; Reid, J G; Renfordt, R E; Richard, A; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zaranek, J; Zimányi, J

    2004-01-01

    Results are presented on event-by-event electric charge fluctuations in central Pb+Pb collisions at 20, 30, 40, 80 and 158 AGeV. The observed fluctuations are close to those expected for a gas of pions correlated by global charge conservation only. These fluctuations are considerably larger than those calculated for an ideal gas of deconfined quarks and gluons. The present measurements do not necessarily exclude reduced fluctuations from a quark-gluon plasma because these might be masked by contributions from resonance decays.

  19. Health screening - women - over age 65

    Science.gov (United States)

    Health maintenance visit - women - over age 65; Physical exam - women - over age 65; Yearly exam - women - over age 65; Checkup - women - over age 65; Women's health - over age 65; Preventive care exam - women - over ...

  20. EFFECTS OF AGING ON PERCEIVED EXERTION AND PAIN DURING ARM CRANKING IN WOMEN 70 TO 80 YEARS OLD

    Directory of Open Access Journals (Sweden)

    Alain Groslambert

    2006-06-01

    Full Text Available The aim of this study was to examine the effects of aging on perceived exertion (PE and perceived arm pain (PaP at the end of a maximal graded arm test in 70- to 80-year -old women. Twelve healthy young (mean age 22.9 ± 3.3 years, and 12 healthy elderly (mean age 74.6 ± 3.7 years women performed a maximal graded test (GXT on an arm crank ergometer until exhaustion. The results revealed no significant difference between both groups concerning PE (p > 0.05; Effect Size = 0.62 and when heart rate (HR was expressed as a theoretical maximal heart rate (THRmax (p > 0.05; Effect Size = 0.17. Nevertheless, PaP was significantly lower (p < 0.05; Effect Size = 2.95 in the elderly compared to the young group. In conclusion, these results suggest that, at the end of GXT, PE is not influenced, whereas PaP may be altered by aging of the women tested in the present study. Therefore, it appears difficult to use PaP in these elderly women to regulate exercise intensity during a training program

  1. CEREBROCARDIAC SYNDROME ON PATIENTS OF OVER SEVENTY AGE AND EEG STUDY

    Institute of Scientific and Technical Information of China (English)

    LIU Mingshun; MEI Fengjun; LI Fengluan; LIU Qingrui; GU Lanjie

    2005-01-01

    Objectives: To observe cerebrocardiac syndrome on patients of the over seventy age and it's change of EEG. Methods: Brain CT and ECG were examined in 50 patients of the over seventy age with cerebrocardiac syndrome. Results: There were obvious changes in the brain CT and ECG. Conclusion:There were obvious changes of brain CT and ECG in cerebrocardiac syndrome of over seventy age patients.

  2. Genetic Background, Maternal Age, and Interaction Effects Mediate Rates of Crossing Over in Drosophila melanogaster Females.

    Science.gov (United States)

    Hunter, Chad M; Robinson, Matthew C; Aylor, David L; Singh, Nadia D

    2016-05-03

    Meiotic recombination is a genetic process that is critical for proper chromosome segregation in many organisms. Despite being fundamental for organismal fitness, rates of crossing over vary greatly between taxa. Both genetic and environmental factors contribute to phenotypic variation in crossover frequency, as do genotype-environment interactions. Here, we test the hypothesis that maternal age influences rates of crossing over in a genotypic-specific manner. Using classical genetic techniques, we estimated rates of crossing over for individual Drosophila melanogaster females from five strains over their lifetime from a single mating event. We find that both age and genetic background significantly contribute to observed variation in recombination frequency, as do genotype-age interactions. We further find differences in the effect of age on recombination frequency in the two genomic regions surveyed. Our results highlight the complexity of recombination rate variation and reveal a new role of genotype by maternal age interactions in mediating recombination rate.

  3. Genetic Background, Maternal Age, and Interaction Effects Mediate Rates of Crossing Over in Drosophila melanogaster Females

    Directory of Open Access Journals (Sweden)

    Chad M. Hunter

    2016-05-01

    Full Text Available Meiotic recombination is a genetic process that is critical for proper chromosome segregation in many organisms. Despite being fundamental for organismal fitness, rates of crossing over vary greatly between taxa. Both genetic and environmental factors contribute to phenotypic variation in crossover frequency, as do genotype–environment interactions. Here, we test the hypothesis that maternal age influences rates of crossing over in a genotypic-specific manner. Using classical genetic techniques, we estimated rates of crossing over for individual Drosophila melanogaster females from five strains over their lifetime from a single mating event. We find that both age and genetic background significantly contribute to observed variation in recombination frequency, as do genotype–age interactions. We further find differences in the effect of age on recombination frequency in the two genomic regions surveyed. Our results highlight the complexity of recombination rate variation and reveal a new role of genotype by maternal age interactions in mediating recombination rate.

  4. Epidemiology Investigation of stroke among Mongolian and Han population aged over 45 in Inner Mongolia.

    Science.gov (United States)

    Zhang, Chunyu; Lan, Tian; Zhe, Yan; Hu, Baolige; Zhang, Guohua; He, Juan; Wang, Zhiguang; Jiang, Mingfang; Hu, Riletemuer

    2017-04-04

    To discuss the status of epidemiology of stroke in the Mongolian and Han population aged over 45 years and to understand the treatment and prevention of stroke. Data collected on stroke populations aged over 45 years in the six areas in Inner Mongolia were analyzed by using stratified multi-stage cluster sampling. The prevalence rate of stroke in patients aged over 45 years in Inner Mongolia was 4.62%. The stroke prevalence rate increased with age in both males and females, the Han and Mongolian populations, and was higher in males than in females in Inner Mongolia. The prevalence rate of stroke in the Mongolian population was higher than in the Han population. The incidence rate of stroke in patients aged over 45 years in Inner Mongolia was 0.28%, of which the rate of relapsed ischemic stroke was 23.29%. The proportion of ischemic stroke in the stroke patients was higher than hemorrhagic stroke. The prevalence and incidence rates of stroke in patients aged over 45 years in Inner Mongolia were high. The prevalence rate of stroke in both the Han population and the Mongolian population increased with age. Ischemic stroke was the major form of stroke.

  5. Exercise training decreases body mass index in subjects aged 50 years and over

    Directory of Open Access Journals (Sweden)

    Ignatio Rika Haryono

    2016-02-01

    Full Text Available Exercise training can improve blood pressure in normotensive, prehypertensive, and hypertensive subjects. One of the mechanisms of blood pressure reduction in hypertensive patients with obesity is through weight loss. This study aimed to examine the effect of exercise training on bodyweight and the relationship between weight loss and reduction of blood pressure. An experimental pre-post test design without controls was used to evaluate the effect of exercise training on weight loss. The study involved 89 elderly aged 50 years or more, consisting of 40 men and 49 women, who were members of Senayan Sport Fitness Club and had been exercising for at least three months. Exercise training was programmed and performed three times a week, consisting of aerobic (walking, jogging, static cycling, and resistance exercise. All exercise was performed for one to two hours with mild to moderate intensity. Blood pressure and body weight were obtained from medical records. Paired t-test showed that systolic blood pressure (SBP, diastolic blood pressure (DBP, mean arterial pressure (MAP, pulse pressure (PP, and body mass index (BMI were significantly lower after training [(systolic, 126.3 ± 2.9 vs 122.3 ± 2.7, p=0.02, (diastolic, 80.2 ± 3.1 vs 77.2 ± 2.4, p=0.00, (MAP, 95.6 ± 4.6 vs 92.2 ± 3.4, p=0.00, (PP, 46.1 ± 4.2 vs 45.1 ± 3.6, p=0.04, (BMI, 24.5 ± 2.9 vs 23.6 ± 2.9, p=0.04]. Duration of training was the most influential factor affecting rBMI, (Beta = 0.38; p=0.00. Exercise training could lower BMI and the reduction in diastolic blood pressure was higher for the subjects aged 70 years and over.

  6. Multiple Chronic Conditions among Adults Aged 45 and Over: Trends Over the Past 10 Years

    Science.gov (United States)

    ... have more physician visits ( 3 ). Out-of-pocket spending is higher for persons with multiple chronic conditions and has increased in recent years ( 5 ). Chronic disease, and combinations of chronic diseases, affects individuals to varying degrees and may impact an individual's ...

  7. The impact and effectiveness of pneumococcal vaccination in Scotland for those aged 65 and over during winter 2003/2004

    Directory of Open Access Journals (Sweden)

    Macfarlane Tatania V

    2008-04-01

    Full Text Available Abstract Background For winter 2003/2004 in Scotland, it was recommended that all those aged 65 and over be eligible to receive 23-valent polysaccharide pneumococcal vaccine (23vPPV, which has been shown to be effective in reducing the risk of invasive pneumococcal disease (IPD. We assessed the success of the vaccination programme by examining the age specific incidence rates of IPD compared to four previous winter seasons and estimating vaccination effectiveness. Methods Winter season incidence rates of IPD for vaccine targeted (65 years and over and non-targeted (0–4, 5–34, 35–49, 50–64 age bands were examined for the Scottish population in a retrospective cohort design for winter 2003/2004. Details of all IPD cases were obtained from the central reference laboratory and population vaccine uptake information was estimated from a GP sentinel practice network. Based on the preceding four winter seasons, standardised incidence ratios (SIR for invasive pneumococcal disease were determined by age-band and sex during winter 2003/2004. Vaccination effectiveness (VE was estimated using both screening and indirect cohort methods. Numbers needed to vaccinate were derived from VE results using equivalent annual incidence estimates for winter 2003/2004. Results Overall vaccination effectiveness using the screening method (adjusted for age and sex in those aged 65 and over was 61.7% (95%CI: 45.1, 73.2 which corresponded to a number needed to vaccinate of 5206 (95%CI: 4388, 7122 per IPD case prevented. Estimated effectiveness for the same age group using the indirect cohort method was not significant at 51% (95%CI: -278, 94. Reductions in the winter season incidence rate of IPD were highly significant for all those aged 75+: males SIR = 58.8 (95%CI: 41.6, 80.8; females SIR = 70.0 (95%CI: 55.1, 87.8. In the 65–74 years age-group, the reduction for females was significant: SIR = 60.3 (95%CI: 39.3, 88.4, but not for males: SIR = 74.8 (95%CI: 50

  8. Fram Strait sea ice export variability and September Arctic sea ice extent over the last 80 years

    Science.gov (United States)

    Smedsrud, Lars H.; Halvorsen, Mari H.; Stroeve, Julienne C.; Zhang, Rong; Kloster, Kjell

    2017-01-01

    A new long-term data record of Fram Strait sea ice area export from 1935 to 2014 is developed using a combination of satellite radar images and station observations of surface pressure across Fram Strait. This data record shows that the long-term annual mean export is about 880 000 km2, representing 10 % of the sea-ice-covered area inside the basin. The time series has large interannual and multi-decadal variability but no long-term trend. However, during the last decades, the amount of ice exported has increased, with several years having annual ice exports that exceeded 1 million km2. This increase is a result of faster southward ice drift speeds due to stronger southward geostrophic winds, largely explained by increasing surface pressure over Greenland. Evaluating the trend onwards from 1979 reveals an increase in annual ice export of about +6 % per decade, with spring and summer showing larger changes in ice export (+11 % per decade) compared to autumn and winter (+2.6 % per decade). Increased ice export during winter will generally result in new ice growth and contributes to thinning inside the Arctic Basin. Increased ice export during summer or spring will, in contrast, contribute directly to open water further north and a reduced summer sea ice extent through the ice-albedo feedback. Relatively low spring and summer export from 1950 to 1970 is thus consistent with a higher mid-September sea ice extent for these years. Our results are not sensitive to long-term change in Fram Strait sea ice concentration. We find a general moderate influence between export anomalies and the following September sea ice extent, explaining 18 % of the variance between 1935 and 2014, but with higher values since 2004.

  9. The Evaluation of Neptune Pad in Hemostasis of Femoral Artery Puncture Point after Interventional Therapy for 25 Patients Aged Over 80 with Cancer%25例超高龄癌症患者股动脉穿刺点Neptune Pad止血贴应用评价

    Institute of Scientific and Technical Information of China (English)

    刘建文; 张同庆; 张怡; 赵丹; 孟娥; 贾晨星; 梁仲侨

    2013-01-01

      目的探讨80岁以上超高龄癌症患者经股动脉穿刺介入治疗后应用Neptune Pad止血贴的疗效及安全性。方法25例(共52次)超高龄癌症患者的股动脉穿刺点应用Neptune Pad止血贴辅助止血。结果52次经股动脉穿刺动脉灌注化疗和/或栓塞后,均无穿刺处并发症发生。结论 Neptune Pad止血贴对超高龄患者的股动脉穿刺止血效果肯定、安全可靠。%  Objective To investigate the safety and efficacy of the Neptune Pad in hemostasis of femoral artery puncture point after interventional therapy. Methods The application of Neptune Pad was 52 times in hemostasis of femoral artery puncture point after interventional therapy for 25 patients aged over 80 with cancer. Results There were no puncture complications in 52 times femoral artery puncture after interventional therapy. Conclusion The application of Neptune Pad for patients aged over 80 with femoral artery puncture haemostatic are effectively and safety.

  10. Language and ageing - exploring propositional density in written language - stability over time.

    Science.gov (United States)

    Spencer, Elizabeth; Craig, Hugh; Ferguson, Alison; Colyvas, Kim

    2012-09-01

    This study investigated the stability of propositional density (PD) in written texts, as this aspect of language shows promise as an indicator and as a predictor of language decline with ageing. This descriptive longitudinal study analysed written texts obtained from the Australian Longitudinal Study of Women's Health in which participants were invited to respond to an open-ended question about their health. The 635 texts used for this study were taken from 127 middle-aged women who responded to this question on each of the five surveys conducted at 3-year intervals over a 16-year period. The study made use of an automated PD rater (CPIDR-3) for the analysis. PD was found to be a stable measure over time when comparing the grouped data, but there was between- and within-subject variation over time. Further research is needed to explore the valid use of this measure in research into language and ageing.

  11. Pancreaticoduodenectomy in the elderly over 80 years:a case repor t

    Institute of Scientific and Technical Information of China (English)

    Hassen Hentati; Hafedh Mestiri; Mohamed Taher Khalfallah; Nafaa Arfa; Noomen Haouas; Sana Landolsi; Walid Gharbi; Nizar Miloudi; Saber Mannaï; Brahim Ghariani; Lassaad Gharbi

    2007-01-01

    BACKGROUND:An increasing number of elderly patients have been considered for major surgical procedures, such as pancreaticoduodenectomy. The decision to recommend this operation for localized pancreatic cancer or other periampullary process in a very elderly patient is complicated by the frailty of the patient and the poor prognosis of the disease. Moreover, increased surgical experience associated with better patient selection may reduce the mortality rate, even in very elderly patients (over 80 years of age), after pancreaticoduodenectomy. METHODS:An 84-year-old woman underwent pancreatico-duodenectomy for ampullary adenocarcinoma. The tumor was classiifed pT3N0M0. RESULT:A good postoperative outcome was obtained. The patient is still alive, 18 months after operation. CONCLUSIONS:Radical resection of periampullary tumors is safe in selected patients of advanced age, with morbidity and mortality rates approaching those observed in younger patients. Age alone should not be a contraindication for pancreatic resection.

  12. Autism Prevalence Trends Over Time in Denmark: Changes in Prevalence and Age at Diagnosis

    DEFF Research Database (Denmark)

    Parner, Erik; Schendel, Diana; Thorsen, Poul

    2008-01-01

    OBJECTIVE: To examine the effect of changing age at diagnosis on the diagnosed prevalence of autism among different birth cohorts. DESIGN: Population-based cohort study. SETTING: Children were identified in the Danish Medical Birth Registry and psychiatric outcomes were obtained via linkage...... with the Danish National Psychiatric Register. PARTICIPANTS: All children born in Denmark from January 1, 1994, through December 31, 1999 (N = 407 458). MAIN OUTCOME MEASURES: The age-specific prevalence, hazard ratio, and relative risk by age. RESULTS: Statistically significant shifts in age at diagnosis were...... prevalence of autism in young children in the more recent cohorts compared with the oldest cohort. This study supports the argument that the apparent increase in autism in recent years is at least in part attributable to decreases in the age at diagnosis over time....

  13. Intake of ruminant trans fatty acids in the Danish population aged 1-80 years

    DEFF Research Database (Denmark)

    Jakobsen, M. U.; Bysted, Anette; Andersen, N. L.

    2006-01-01

    Objective: To estimate the intake of ruminant trans fatty acids (TFA) in the Danish population aged 1 - 80 years. Design: Descriptive study. Subjects: A sex- and age-stratified random sample drawn from the Danish Civil Registration System. A total of 3098 participants (51% female) aged 1 - 80 yea...

  14. Evaluation of the results from arthroscopic surgical treatment of rotator cuff injuries in patients aged 65 years and over

    Directory of Open Access Journals (Sweden)

    Alberto Naoki Miyazaki

    2015-06-01

    Full Text Available OBJECTIVES: To evaluate the results from arthroscopic surgical treatment of rotator cuff injuries in patients aged 65 years and over.METHODS: Between 1998 and 2009, 168 patients underwent operations. Five cases were excluded. The remaining 163 patients were stratified according to their age group: 65-69 years (49.1%, 70-74 (26.4% and 75 years and over (24.5%. Their mean age was 71 years (range: 65-83. There were 63 male patients (38.7%. The mean length of time with pain, from the onset of symptoms to the surgery, was 23 months (range: 2 days to 240 months. Sixty-two patients (38% reported histories of trauma and 26 (16% reported that their pain worsened through exertion.RESULTS: From the UCLA criteria, 80.4% of the results were excellent, 16% good, 1.8% fair and 1.8% poor. Complications occurred in 11%. The final clinical result did not show any correlation with age progression, injury size or tendons affected. However, there was a significant association (p < 0.001 between the presence of trauma and larger injuries. The length of time between the onset of symptoms and the surgical procedure had a significant relationship (p < 0.027 with the postoperative results: the longer this time was, the worse the results were.CONCLUSION: Arthroscopic treatment of rotator cuff injuries in patients aged 65 years and over presented excellent and good results in 96.4% of the cases, according to the UCLA assessment, with a low complication rate. Advanced age did not show any influence on the postoperative clinical evolution, but the earlier the surgical treatment was instituted, the better the results were.

  15. Corrosion behavior of extrusion, under-aged, peaked-aged and over-aged WE93 alloys in NaHSO3 solutions

    Institute of Scientific and Technical Information of China (English)

    蒋全通; 马鸣龙; 张奎; 李兴刚; 李永军; 石国梁; 袁家伟

    2014-01-01

    The corrosion behaviors of extrusion, under-aged, peaked-aged and over-aged WE93 alloys in NaHSO3 solutions were in-vestigated by optical microscopy (OM), scanning electron microscopy (SEM) and X-ray diffraction (XRD). The weight loss rates, corrosion morphologies and polarization curves were analyzed. The peak-aged specimen in NaHSO3 salt spray had the highest corro-sion rate of 0.9787 mg/cm2/d, while extrusion specimen led to the lowest of 0.2184 mg/cm2/d. The specimens could be arranged in decreasing order of corrosion rates:extrusionaged. Polarization curves also gave effective evaluation of corrosion rates in agreement. The NaHSO3 played a great role in the corrosion behaviors of WE93 alloys. The main reasons were that HSO3–developed a reaction:O2+2HSO3–+2e→2HSO42–→2H++2SO42–to generate H+, accelerating the process of corrosion re-action. SO42–stimulated corrosion and led to an autocatalytic type of reaction:Mg2++SO42–+7H2O→MgSO4–7H2O. XRD character-ized that Mg(OH)2 and MgSO4·7H2O were the main corrosion products.

  16. 23 CFR Appendix C to Part 658 - Trucks Over 80,000 Pounds on the Interstate System and Trucks Over STAA Lengths on the National...

    Science.gov (United States)

    2010-04-01

    ... all trailer(s) and converter dolly axles. A brake force limiting valve, sometimes called a “slippery... combination shall consist of a truck tractor, first semitrailer, fifth-wheel converter dolly, and a second semitrailer. The converter dolly may be either a separate unit or an integral component of the...

  17. Enthalpy and entropy changes during physical ageing of 20% polystyrene–80% poly(α-methylstyrene) blend and the cooling rate effects

    Energy Technology Data Exchange (ETDEWEB)

    Righetti, M.C., E-mail: cristina.righetti@ipcf.cnr.it; Johari, G.P.

    2015-05-10

    Highlights: • Aging of polystyrene–poly(α-methylstyrene) blend studied by DSC. • Model-free thermodynamics used to analyse the temperature, time and cooling rate effects. • Aging kinetics differ from the α-relaxation dynamics. • Fictive temperature’s change interpreted in terms of aging kinetics. - Abstract: Certain compositions of polymer blends remain mixed in the glassy state, and demix on heating and may demix or otherwise change on physical aging. To investigate these effects, we studied the loss of enthalpy and entropy of a 20% polystyrene–80% poly(α-methylstyrene) blend: (i) after aging it for varying periods at a fixed temperature, (ii) after aging it for a fixed period at various temperatures and (iii) after vitrifying it at two different cooling rates prior to the physical aging. The results have been analysed by: (a) fitting the TNM model for a non-exponential, non-linear relaxation, and (b) by determining the enthalpy and entropy loss on aging. A single set of TNM model-fit parameters did not fit the data obtained for different cooling rates, and for the physically aged blend, and for some conditions a sub-T{sub g} feature known from previous studies of pure polymers appeared. The enthalpy and entropy on physical aging are found to decrease non-exponentially, but the exponent, β{sup age}, and the characteristic time, τ{sub a} (i.e., reciprocal of the rate constant of aging-kinetics), differ from the β{sup cal} and τ{sub 0} determined by fitting the TNM model to the data. This indicates that either τ{sub a} itself is time-dependent during the relaxation, and/or β{sup age} varies with the temperature. Since the characteristic time of the α-relaxation process and its non-exponential parameter refer to density and structure fluctuations in a state of fixed volume and energy, these two are neither expected to be the same as the characteristic time and the parameter observed for aging, nor are they found to be the same. We also discuss

  18. Short and long term outcomes of primary angioplasty in patients aged 75 years and over

    Directory of Open Access Journals (Sweden)

    Turgay Işık

    2011-06-01

    Full Text Available The treatment of elderly patients with ST segment elevated myocardial infarction (STEMI remains controversial. This study aimed to investigate the effects of primary angioplasty in elderly patients on in-hospital and long term major adverse cardiac events (MACE.Materials and methods: From October 2003 to March 2008, we retrospectively enrolled 220 patients aged 75 years and over with STEMI who underwent primary angioplasty. Patients’ characteristics, in-hospital and long term events were recorded.Results: Male/Female ratio of patients was 129/91 and mean age was 78.7 ± 3.6 (range, 75-97 years, and 58.6% of male. Of these patients 29.2% were diabetics, 69.8% were hypertensive, 34.4% were smoker and 43.5% were anemic at admission. Anterior myocardial infarction was diagnosed in 52.3% of patients. Mean pain-balloon time was 222 ± 116 minutes. Eighty two (38.2% of these 220 patients had three-vessel disease and 12 (5.7% were diagnosed as cardiogenic shock. Procedural success was observed in 79.6% of patients. Heart failure was observed 27.7% in hospital and intra aortic pump was used in 14.5% of patients. There was no significant difference between age groups in long term major cardiac events and in hospital mortality. Diabetes, leukocyte count at admission and in hospital heart failure were independent predictors of short term MACE and low hemoglobin level at admission and peak CKMB levels were independent predictors of long term MACE.Conclusions: Primary angioplasty in patients aged 75 years and over seems to be associated with low procedural complication, high procedural success, improved short and long term survival.

  19. Pondering over Some Chinese And Western Poems about Old Age%Pondering over Some Chinese And Wwstern Poems about Old Age

    Institute of Scientific and Technical Information of China (English)

    夏宏忖; 吴春容

    2007-01-01

    Through a comparative appreciation of Chinese and Western poems about old age, the present article tends to present a general convey of the western and eastern poets' attitudes and feelings towards old age, which is an aspect of human culture. The main themes are almost the same: reminiscence (sweet or bitter), solitude,contentment, detachment, sorrow and sentiment. But the Western are more optimistic and admire youth, regard old age as a natural stage of life. The Chinese, more conservative and perfectionist, show much more respect to the old, and think more about the past unfulfilled.

  20. Rapidity and transverse momentum dependence of pion-pion Bose-Einstein correlations measured at 20, 30, 40, 80, and 158 AGeV beam energy

    CERN Document Server

    Kniege, S; Anticic, T; Baatar, B; Barna, D; Bartke, Jerzy; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Darmenov, N; Dimitrov, A; Dinkelaker, P; Eckardt, V; Farantatos, G; Filip, P; Flierl, D; Fodor, Z; Foka, P Y; Freund, P; Friese, V; Gál, J; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Grebieszkow, K; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kliemant, M; Kolesnikov, V I; Kollegger, T; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Van Leeuwen, M; Lévai, Peter; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Markert, C; Mateev, M; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Pálla, G; Panagiotou, A D; Panayotov, D; Petridis, A; Pikna, M; Pinsky, L; Pühlhofer, F; Reid, J G; Renfordt, R E; Richard, A; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zaranek, J; Zimányi, J; Kniege, Stefan

    2004-01-01

    Preliminary results on pion-pion Bose-Einstein correlations in central Pb+Pb collisions measured by the NA49 experiment are presented. Rapidity as well as transverse momentum dependence of the HBT-radii are shown for collisions at 20, 30, 40, 80, and 158 AGeV beam energy. Including results from AGS and RHIC experiments only a weak energy dependence of the radii is observed. Based on hydrodynamical models parameters like lifetime and geometrical radius of the source are derived from the dependence of the radii on transverse momentum.

  1. Comparison of arthroscopic rotator cuff repair in healthy patients over and under 65 years of age.

    Science.gov (United States)

    Osti, Leonardo; Papalia, Rocco; Del Buono, Angelo; Denaro, Vincenzo; Maffulli, Nicola

    2010-12-01

    We compared the outcomes of arthroscopically repaired rotator cuff tears in 28 patients older than 65 years (the over 65 group: median age 70 years) with a control group of 28 patients younger than 65 years (the under 65 group: median age 57 years). The groups were similar in regard to sex distribution, surgical technique, and post-operative rehabilitation programmes, but different in age. After careful arthroscopic evaluation of the full-thickness rotator cuff tear, rotator cuff repair and biceps tenotomy were performed in all patients. Pre- and post-operatively, each patient was evaluated for range of motion, shoulder score (UCLA), and SF-36 self-administered questionnaire. Comparing pre- versus post-operative status at a minimum 24 months follow-up, forward elevation, internal and external rotation, modified UCLA rating system scores, and SF-36 scores improved significantly in both groups, with no significant difference between the groups. At the last follow-up, strength improved significantly in both groups, with non-significant intergroup difference. The Popeye sign was detected in 13/28 (46%) of the patients in the over 65 group and in 11/28 (39%) in the under 65 group (χ = 0.29) with non-significant difference between the two groups. In selected active patients older than 65, arthroscopic rotator cuff repair associated with biceps tenotomy (when necessary) can yield clinical and related quality of life outcomes similar to those of patients younger than 65 years.

  2. Neurological and functional outcomes of subdural hematoma evacuation in patients over 70 years of age

    Directory of Open Access Journals (Sweden)

    Patrick Mulligan

    2013-01-01

    Full Text Available Background: Subdural hematoma (SDH is a common disease entity treated by neurosurgical intervention. Although the incidence increases in the elderly population, there is a paucity of studies examining their surgical outcomes. Objectives: To determine the neurological and functional outcomes of patients over 70 years of age undergoing surgical decompression for subdural hematoma. Materials and Methods: We retrospectively reviewed data on 45 patients above 70 years who underwent craniotomy or burr holes for acute, chronic or mixed subdural hematomas. We analyzed both neurological and functional status before and after surgery. Results: Forty-five patients 70 years of age or older were treated in our department during the study period. There was a significant improvement in the neurological status of patients from admission to follow up as assessed using the Markwalder grading scale (1.98 vs. 1.39; P =0.005, yet no improvement in functional outcome was observed as assessed by Glasgow Outcome Score. Forty-one patients were admitted from home, however only 20 patients (44% were discharged home, 16 (36% discharged to nursing home or rehab, 6 (13% to hospice and 3 (7% died in the postoperative period. Neurological function improved in patients who were older, had a worse pre-operative neurological status, were on anticoagulation and had chronic or mixed acute and chronic hematoma. However, no improvement in functional status was observed. Conclusion: Surgical management of SDH in patients over 70 years of age provides significant improvement in neurological status, but does not change functional status.

  3. Predictors of five-year functional ability in a longitudinal survey of men and women aged 75 to 80. The 1914-population in Glostrup, Denmark

    DEFF Research Database (Denmark)

    Schroll, M; Avlund, K; Davidsen, M

    1997-01-01

    in mobility functions. "Stability" in mobility functions was related to ability to mount stairs, walking speed, mood and physical activity. Number of chronic diseases and low pulmonary function were only related to mobility in men. Among people who improved their function, many had rather low baseline......-based, representative sample, the objectives were: to describe five-year outcome regarding death and functional ability to age 75 to 80, as well as individual changes in muscle strength, physical performance in simple function tests and self-reported physical activity, and relate "risk markers" to five-year outcome....... Baseline values were obtained in 405 participants in the 1989-survey of the 1914-cohort in Copenhagen County. The 307 survivors were invited for the survey of 80-year olds in 1995. Outcome was measured as death, non-participation, decline, stability or improvement in two measures of mobility function...

  4. U.S. Life Expectancy May Rise to Over 80 by 2030

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_163698.html U.S. Life Expectancy May Rise to Over 80 by ... Medicine, the National Institutes of Health, or the U.S. Department of Health and Human Services. More Health ...

  5. Comparisons of neurodegeneration over time between healthy ageing and Alzheimer's disease cohorts via Bayesian inference

    Science.gov (United States)

    Mengersen, Kerrie

    2017-01-01

    Objectives In recent years, large-scale longitudinal neuroimaging studies have improved our understanding of healthy ageing and pathologies including Alzheimer's disease (AD). A particular focus of these studies is group differences and identification of participants at risk of deteriorating to a worse diagnosis. For this, statistical analysis using linear mixed-effects (LME) models are used to account for correlated observations from individuals measured over time. A Bayesian framework for LME models in AD is introduced in this paper to provide additional insight often not found in current LME volumetric analyses. Setting and participants Longitudinal neuroimaging case study of ageing was analysed in this research on 260 participants diagnosed as either healthy controls (HC), mild cognitive impaired (MCI) or AD. Bayesian LME models for the ventricle and hippocampus regions were used to: (1) estimate how the volumes of these regions change over time by diagnosis, (2) identify high-risk non-AD individuals with AD like degeneration and (3) determine probabilistic trajectories of diagnosis groups over age. Results We observed (1) large differences in the average rate of change of volume for the ventricle and hippocampus regions between diagnosis groups, (2) high-risk individuals who had progressed from HC to MCI and displayed similar rates of deterioration as AD counterparts, and (3) critical time points which indicate where deterioration of regions begins to diverge between the diagnosis groups. Conclusions To the best of our knowledge, this is the first application of Bayesian LME models to neuroimaging data which provides inference on a population and individual level in the AD field. The application of a Bayesian LME framework allows for additional information to be extracted from longitudinal studies. This provides health professionals with valuable information of neurodegeneration stages, and a potential to provide a better understanding of disease pathology

  6. Age effect of male and female broiler breeders on sperm penetration of the perivitelline layer overlying the germinal disc.

    Science.gov (United States)

    Bramwell, R K; McDaniel, C D; Wilson, J L; Howarth, B

    1996-06-01

    An experiment was conducted to test the effect of age (male and female) on the number of spermatozoa penetrating the perivitelline layer (PL) overlying the germinal disc (GD) in broiler breeders. Eighty young broiler breeder hens (39 wk old, Y), and 80 old spent broiler breeder hens (69 wk old, O) were randomly divided into eight groups of 20 hens each by age. Hens were inseminated weekly for 4 consecutive wk with 5 x 10(7) pooled sperm/50 microL from either young or old broiler breeder males. Sperm penetration (SP) of the PL at the GD was assessed in a random sample of 12 oviposited eggs from each hen group for each day postinsemination, with the remainder of the eggs incubated for 10 d to obtain fertility values. For the main effect of sex, and for age within sex, there were differences in mean SP (7.3 vs 4.8; Y vs O hens; P hens; P artificial insemination of a constant number of sperm, age of hens appears to contribute more to the decrease in SP and fertility than the age of male broiler breeders. Eggs were obtained from naturally mated broiler breeder flocks from different strains (A and B), lines (male and female), and ages. There was an effect on overall mean SP values due to strain (105.8 vs 78.6 holes per GD area; Strains A and B, respectively; P < 0.0001), and line within Strain B (106.4 vs 50.8 holes per GD; male and female line, respectively; P < 0.0001). There was a quadratic relationship between SP of the PL and age in Strain A with values ranging from 153.3 to 20.0 holes per GD area (P < 0.003). In Strain B, SP holes in the PL decreased in the male line due to age (127.8 to 59.7 per GD; P < 0.01), with an effect of age on the female line also (62.1 vs. 37.8 holes per GD; P < 0.05).

  7. Relating with God Contributes to Variance in Happiness, over that from Personality and Age

    Directory of Open Access Journals (Sweden)

    John Fisher

    2013-06-01

    Full Text Available A previous study on university students reported that personal, communal, and environmental spiritual well-being contributed to happiness over and above personality but that relating with God did not. In this study, happiness was assessed using a modified Oxford Happiness Inventory. Personality scores were obtained using forms of Eysenck’s Personality Questionnaire. Four domains of spiritual well-being were determined using Fisher’s Spiritual Well-Being Questionnaire. Relationship with God was reflected by the Transcendental domain of spiritual well-being in this instrument. Studies with 466 university students from Australia, Northern Ireland, and England, 494 people attending churches in Ballarat, and 1002 secondary school students in Victoria showed that relating with God accounts for variance on happiness, over and above personality, and age.

  8. Germ-line transmission of trisomy 21: Data from 80 families suggest an implication of grandmaternal age and a high frequency of female-specific trisomy rescue

    Directory of Open Access Journals (Sweden)

    Kovaleva Natalia V

    2010-03-01

    Full Text Available Abstract Background Trisomy of chromosome 21 (T21; Down syndrome, DS is the most common aneuploidy in live births. Though its etiology has been intensively studied for a half of century, there are surprisingly many problems awaiting their elucidation. Some of the open questions are related directly to germ line mosaicism for T21, other problems include the prevalence of males with non-mosaic trisomy over females (skewed sex ratio, SR, the genetic predisposition to non-disjunction, etc. Studies in families of gonadal mosaicism (GM carriers might help resolving some of these problems. Results 80 families of carriers of GM, in which the sex of the offspring had been specified, were identified in the literature and in logbooks of two local genetic units. Mothers in these families were relatively young: only 8% of mothers were 35 years old and older at the time of delivery of their first affected offspring while the proportion of grandmothers on the GM carrier's side aged 35 years old and older was significantly higher (39%. Postzygotic rescue of T21 due to error in the meiosis I had been proposed as a mechanism of parental GM formation in 78% of the families with known origin of the T21. For the other 22%, rescue of errors in the meiosis II or postzygotic mitotic non-disjunction was assumed. Mosaicism for T21 in successive generations was reported in at least 12 families. The proportion of mosaics among affected female offspring (14% is significantly higher compared to that among affected male offspring (0%. Male preponderance (SR = 1.5 is found in non mosaic liveborn offspring with either maternally- or paternally transmitted T21. Among unaffected offspring of male carriers of GM there is a notable excess of females (SR = 0.27. Conclusion Both direct (results of cytogenetic and molecular study of the origin of trisomic line and indirect (advanced grandmaternal age on the side of GM carrier evidences allow to assume that significant proportion of

  9. Confabulation in healthy aging is related to poor encoding and retrieval of over-learned information.

    Science.gov (United States)

    Attali, Eve; Dalla Barba, Gianfranco

    2013-01-01

    Normal aging is characterized by deficits that cross multiple cognitive domains including episodic memory and attention. Compared to young adults (YA), older adults (OA) not only show reduction in true memories, but also an increase in false memories. In this study we aim to elucidate how the production of confabulation is influenced by encoding and retrieval processes. We hypothesized that in OA, compared to YA, over-learned information interferes with the recall of specific, unique past episodes and this interference should be more prominent when a concurrent task perturbs the encoding of the episodes to be recalled. We tested this hypothesis using an experimental paradigm in which a group of OA and a group of YA had to recall three different types of story: a previously unknown story, a well-known fairy tale (Snow White), and a modified well-known fairy tale (Little Red Riding Hood is not eaten by the wolf), in three different experimental conditions: (1) free encoding and free retrieval; (2) Divided attention (DA) at encoding and free retrieval; and (3) free encoding and DA at retrieval. Results showed that OA produced significantly more confabulations than YA, particularly, in the recall of the modified fairy tale. Moreover, DA at encoding markedly increased the number of confabulations, whereas DA at retrieval had no effect on confabulation. Our findings reveal the implications of two phenomena in the production of confabulation in normal aging: the effect of poor encoding and the interference of strongly represented, over-learned information in episodic memory recall.

  10. Nocturia and associated morbidity in a Danish population of men and women aged 60-80 years

    DEFF Research Database (Denmark)

    Bing, M.H.; Moller, L.A.; Jennum, P.;

    2008-01-01

    OBJECTIVE To evaluate the association between nocturia and medical diseases, medication, urinary incontinence (UI), recurrent cystitis, smoking, alcohol, parity, hysterectomy, pelvic organ prolapse surgery, UI surgery. and prostate surgery. SUBJECTS AND METHODS The previously validated questionna...

  11. Evaluation of Relationship between Parity and Coronary Artery Diseases in Women with Age Over 50 Years

    Directory of Open Access Journals (Sweden)

    M. Gharakhani

    2006-04-01

    Full Text Available Introduction & Objective: The coronary artery disease (CAD is the second cause of mortality in women over 40. The risk factors of CAD in females include: age over 55, BP>140/90, smoking and hyperlipidemia. As plasma lipoprotein level changes significantly during pregnancy, low density lipoprotein reaches its peak approximately in the week 36 of pregnancy. Hypercholesterolemia induced by pregnancy may be atherogen. The purpose of this study was to evaluate the relationship between multi-parity and CAD. Material & Methods: In this case-control study 230 women over 50 y were studied in the Ekbatan Hospital, Hamadan in 2005. 115 subjects out of them were considered as case group, who were selected among admitted patients with CAD in the heart ward. Other 115 cases without CAD who were admitted in internal and surgery wards, with normal cardiovascular consultation were selected as control group. Patients with known risk factors such as hypertension, hyperlipidemia, diabetic, obesity, active and passive smoker, Type A personality and any record of hormone replacement therapy were excluded. The data were analyzed using the commercially available software package SPSS version 11. Student׳s t-test and χ2 were used for analysis and results were expressed as mean ± SD, and p<0.05 was considered as significant level.Results: Mean ages of the first parity in case and control groups were 16.092 and 16.32 y respectively that the difference was not statistically significant. Mean of parity in case and control groups was 7.53.1 and 5.91.9 respectively (P<0.001. The average of cholesterol, HDL and LDL in control group were 164.2, 102.6 and 34.5 mg/dl respectively, and in control they were 164.1, 105.4 and 40.5 mg/dl respectively. Conclusion: Exposure with repeated hyperlipidemia induced pregnancy may increase the risk of CAD particularly in women with more than 4 parity. Age of the first pregnancy was not observed as a risk factor of CAD.

  12. Dental caries, periodontal disease, and cardiac arrhythmias in community-dwelling older persons aged 80 and older: is there a link?

    DEFF Research Database (Denmark)

    Holm-Pedersen, Poul; Avlund, Kirsten; Morse, Douglas E

    2005-01-01

    lesions had 2.8 times higher odds (95% confidence interval=1.1-7.0) of arrhythmia than persons without active coronal caries, but there was no greater risk for persons with three or more coronal caries lesions. There was no association between periodontal disease and arrhythmia. CONCLUSION: The findings......OBJECTIVES: To examine whether caries or periodontitis is associated with cardiac arrhythmias in community-dwelling people aged 80 and older. SETTING: Urban, community-based population in Stockholm, Sweden. DESIGN: Cross-sectional. PARTICIPANTS: Eligible persons were identified through...... by a physician or the Stockholm Inpatient Register. Active root caries, active coronal caries, and periodontitis were assessed using previously defined National Institute of Dental and Craniofacial Research diagnostic criteria. RESULTS: The primary finding of the multivariate logistic regression analysis...

  13. Oral health of individuals aged 3-80 years in Jönköping, Sweden during 40 years (1973-2013). II. Review of clinical and radiographic findings.

    Science.gov (United States)

    Norderyd, Ola; Koch, Göran; Papias, Apostolos; Köhler, Alkisti Anastassaki; Helkimo, Anna Nydell; Brahm, Carl-Otto; Lindmark, Ulrika; Lindfors, Ninita; Mattsson, Anna; Rolander, Bo; Ullbro, Christer; Gerdin, Elisabeth Wärnberg; Frisk, Fredrik

    2015-01-01

    The aim of this epidemiological study performed in 2013 was to analyze various clinical and radiographic data on oral health and compare the results to those of four cross-sectional studies carried out 1973-2003. In 1973, 1983, 1993, 2003, and 2013 random samples of 1,000; 1,104; 1,078; 987; and 1,010 individuals, respectively, were studied. The individuals were evenly distributed in the age groups 3, 5, 10, 15, 20, 30, 40, 50, 60, 70, and 80o years. Eighty-year-olds were not included in 1973. All subjects were inhabitants of the city of Jönköping, Sweden. The clinical and radiographic examination assessed edentulousness, removable dentures, implants, number of teeth, caries, restorations, oral hygiene, calculus, periodontal status, and endodontic treatment. The frequency of edentulous individuals aged 40-70 years was 16, 12, 8, 1, and 0.3% in 1973, 1983, 1993, 2003, and 2013, respectively. No complete denture weareryounger than 80-years old was found in 2013. During the 40-year period, the mean number of teeth in the age groups 30-80 years increased. In 2013, the 60-year-olds had nearly complete dentitions. Implants were found in all age groups from 30 years of age. The total number of individuals with implants was 36 in 2013. This was higher than earlier surveys, 4 in 1993, and 18 in 2003. The percentage of children and adults without caries and restorations increased during the 40-year period. It was found that the percentage of caries-free 3- and 5-year-olds were 79% and 69%, respectively, of the individuals in 2013. In the age groups 10-20 years, the percentage of caries-free individuals increased between 2003 and 2013. In 2013, 43% of the 15-year-olds were completely free from caries and restorations compared to 20% in 2003. In all age groups 5-60 years, DFS was lower in 2013 compared to the earlier examinations.There was no major change in DFS between 2003 and 2013 in the age groups 70 and 80 years. The most obvious change was the decrease in number of FS

  14. Modelling the chemically aged and mixed aerosols over the eastern central Atlantic Ocean – potential impacts

    Directory of Open Access Journals (Sweden)

    M. Astitha

    2010-07-01

    Full Text Available Detailed information on the chemical and physical properties of aerosols is important for assessing their role in air quality and climate. This work explores the origin and fate of continental aerosols transported over the Central Atlantic Ocean, in terms of chemical composition, number and size distribution, using chemistry-transport models, satellite data and in situ measurements. We focus on August 2005, a period with intense hurricane and tropical storm activity over the Atlantic Ocean. A mixture of anthropogenic (sulphates, nitrates, natural (desert dust, sea salt and chemically aged (sulphate and nitrate on dust aerosols is found entering the hurricane genesis region, most likely interacting with clouds in the area. Results from our modelling study suggest rather small amounts of accumulation mode desert dust, sea salt and chemically aged dust aerosols in this Atlantic Ocean region. Aerosols of smaller size (Aitken mode are more abundant in the area and in some occasions sulphates of anthropogenic origin and desert dust are of the same magnitude in terms of number concentrations. Typical aerosol number concentrations are derived for the vertical layers near shallow cloud formation regimes, indicating that the aerosol number concentration can reach several thousand particles per cubic centimetre. The vertical distribution of the aerosols shows that the desert dust particles are often transported near the top of the marine cloud layer as they enter into the region where deep convection is initiated. The anthropogenic sulphate aerosol can be transported within a thick layer and enter the cloud deck through multiple ways (from the top, the base of the cloud, and by entrainment. The sodium (sea salt related aerosol is mostly found below the cloud base. The results of this work may provide insights relevant for studies that consider aerosol influences on cloud processes and storm development in the Central Atlantic region.

  15. Chemically aged and mixed aerosols over the Central Atlantic Ocean – potential impacts

    Directory of Open Access Journals (Sweden)

    H. A. C. Denier van der Gon

    2010-02-01

    Full Text Available Detailed information on the chemical and physical properties of aerosols is important for assessing their role in air quality and climate. This work explores the origin and fate of continental aerosols transported over the Central Atlantic Ocean, in terms of chemical composition, number and size distribution, using chemistry-transport models, satellite data and in situ measurements. We focus on August 2005, a period with intense hurricane and tropical storm activity over the Atlantic Ocean. A mixture of anthropogenic (sulphates, nitrates, natural (desert dust, sea salt and chemically aged (sulphate and nitrate on dust aerosols is found entering the hurricane genesis region, most likely interacting with clouds in the area. Results from our modelling study suggest rather small amounts of accumulation mode desert dust, sea salt and chemically aged dust aerosols in this Atlantic Ocean region. Aerosols of smaller size (Aitken mode are more abundant in the area and in some occasions sulphates of anthropogenic origin and desert dust are of the same magnitude in terms of number concentrations. Typical aerosol number concentrations are derived for the vertical layers near shallow cloud formation regimes, designating that the aerosol number concentration can reach several thousand particles per cubic centimetre. The vertical distribution of the aerosols indicates that the desert dust particles are often transported near the top of the marine cloud layer as they enter into the region where deep convection is initiated. The anthropogenic sulphate aerosol can be transported within a thick layer and enter the cloud deck through multiple ways (from the top, the base of the cloud and entrainment. The sodium (sea salt related aerosol is mostly found below the cloud base. The results of this work may provide insights relevant for studies that consider aerosol influences on cloud processes and storm development in the Central Atlantic region.

  16. Chemically aged and mixed aerosols over the Central Atlantic Ocean - potential impacts

    Science.gov (United States)

    Astitha, M.; Kallos, G.; Spyrou, C.; O'Hirok, W.; Lelieveld, J.; Denier van der Gon, H. A. C.

    2010-02-01

    Detailed information on the chemical and physical properties of aerosols is important for assessing their role in air quality and climate. This work explores the origin and fate of continental aerosols transported over the Central Atlantic Ocean, in terms of chemical composition, number and size distribution, using chemistry-transport models, satellite data and in situ measurements. We focus on August 2005, a period with intense hurricane and tropical storm activity over the Atlantic Ocean. A mixture of anthropogenic (sulphates, nitrates), natural (desert dust, sea salt) and chemically aged (sulphate and nitrate on dust) aerosols is found entering the hurricane genesis region, most likely interacting with clouds in the area. Results from our modelling study suggest rather small amounts of accumulation mode desert dust, sea salt and chemically aged dust aerosols in this Atlantic Ocean region. Aerosols of smaller size (Aitken mode) are more abundant in the area and in some occasions sulphates of anthropogenic origin and desert dust are of the same magnitude in terms of number concentrations. Typical aerosol number concentrations are derived for the vertical layers near shallow cloud formation regimes, designating that the aerosol number concentration can reach several thousand particles per cubic centimetre. The vertical distribution of the aerosols indicates that the desert dust particles are often transported near the top of the marine cloud layer as they enter into the region where deep convection is initiated. The anthropogenic sulphate aerosol can be transported within a thick layer and enter the cloud deck through multiple ways (from the top, the base of the cloud and entrainment). The sodium (sea salt related) aerosol is mostly found below the cloud base. The results of this work may provide insights relevant for studies that consider aerosol influences on cloud processes and storm development in the Central Atlantic region.

  17. Modelling the chemically aged and mixed aerosols over the eastern central Atlantic Ocean - potential impacts

    Science.gov (United States)

    Astitha, M.; Kallos, G.; Spyrou, C.; O'Hirok, W.; Lelieveld, J.; Denier van der Gon, H. A. C.

    2010-07-01

    Detailed information on the chemical and physical properties of aerosols is important for assessing their role in air quality and climate. This work explores the origin and fate of continental aerosols transported over the Central Atlantic Ocean, in terms of chemical composition, number and size distribution, using chemistry-transport models, satellite data and in situ measurements. We focus on August 2005, a period with intense hurricane and tropical storm activity over the Atlantic Ocean. A mixture of anthropogenic (sulphates, nitrates), natural (desert dust, sea salt) and chemically aged (sulphate and nitrate on dust) aerosols is found entering the hurricane genesis region, most likely interacting with clouds in the area. Results from our modelling study suggest rather small amounts of accumulation mode desert dust, sea salt and chemically aged dust aerosols in this Atlantic Ocean region. Aerosols of smaller size (Aitken mode) are more abundant in the area and in some occasions sulphates of anthropogenic origin and desert dust are of the same magnitude in terms of number concentrations. Typical aerosol number concentrations are derived for the vertical layers near shallow cloud formation regimes, indicating that the aerosol number concentration can reach several thousand particles per cubic centimetre. The vertical distribution of the aerosols shows that the desert dust particles are often transported near the top of the marine cloud layer as they enter into the region where deep convection is initiated. The anthropogenic sulphate aerosol can be transported within a thick layer and enter the cloud deck through multiple ways (from the top, the base of the cloud, and by entrainment). The sodium (sea salt related) aerosol is mostly found below the cloud base. The results of this work may provide insights relevant for studies that consider aerosol influences on cloud processes and storm development in the Central Atlantic region.

  18. 80岁以上患者外科急腹症的诊治特点%Characteristics in elderly patients over 80 years old with acute abdomen

    Institute of Scientific and Technical Information of China (English)

    郑亚民; 曹锋; 刘强; 刘东斌; 王悦华; 刘家峰; 李非

    2011-01-01

    目的 分析≥80岁外科急腹症住院患者的诊治特点.方法 将2002年1月1日至2009年12月31日外科急腹症入院治疗的5426例患者按年龄分为≥80岁组和<80岁组.观察≥80岁急腹症患者人数、所占比例、病种分布、伴发疾病等特点;统计分析手术比率、治疗效果、病死率、住院时间和住院花费.结果我院8年来纳入患者5426例,≥80岁患者420例,数量和所占百分比总体呈逐年增加趋势.患者从症状发作到就诊时间差2 h至21 d不等.常伴发多种疾病,以呼吸和心血管系统疾病居多.≥80岁组与<80岁组比较,急诊手术率下降(48.09% 比 64.19%,P<0.01),病死率增加(3.33% 比 1.38%,P<0.01),住院时间延长[(16.76±11.49)d 比 (14.50±16.08)d,P<0.01)],人均住院花费增加[(23 733.11±30 571.75)元比(18 530.83±29 637.46)元,P<0.01)].结论 根据≥80岁患者的发病特点制定个体化诊治方案;在制定卫生经济学政策和医疗保险制度时,注意考虑年龄对住院患者病死率、住院时间和治疗费用的影响.%Objective To evaluate the characteristics of diagnosis and treatment in elderly patients over 80 years old with acute abdomen. Methods 5426 elderly patients with acute abdomen were enrolled from January 1,2002 to December 31, 2009 in our hospital and were divided into two groups according age: one group with patients ≥ 80 years old(420 cases) and another group < 80 years old( 5006 cases). Data were analyzed include operability rate, mortality, lenght of stay and admission fee. Results More and more aged patients were treated in hospital. They went to hospital in from 2 h to 21 d after unfitness. They often have several complications including respiratory, cardiovascular system diseases. Compared with < 80 group, operability rate was lower (48.09% vs 64. 19%, P < 0. 01 ), mortality was higher ( 3.33% vs 1.38% ,P <0. 01 ) ,mean hospital length of stay was longer ( 16.76 ± 11.49 d vs 14. 50

  19. Survival Analysis of Non-Small Cell Lung Cancer in Patients Aged 70 and over

    Directory of Open Access Journals (Sweden)

    Jiankun SUN

    2008-04-01

    Full Text Available Background and Objective With a trend of worldwide increasing incidence of elderly population, more and more people pay close attention to diseases in the elderly. Lung cancer is a typical disease of the elderly patients. Around one-third of all patients with non-small cell lung cancer (NSCLC are over the age of 70. Many authors use the age 70 to define the elderly patients in lung cancer. The objective of this study is to evaluate the survival of patients older than 70 with NSCLC and explore the independent prognostic factors in this group of patients. Methods 148 elderly patients with NSCLC were reviewed. All the potential prognostic factors, including sex, age, smoke, symptoms, pathological types, clinical stage, ECOG performance status, complication, focus resection, radiotherapy and chemotherapy were analyzed by COX regression in SPSS 13.0 software. Results After 5-168 months follow-up, 119 patients died, the overall survival rate was 19.6%. 1,2,3,5-year survival rates were 43.2%, 19.0%, 9.0% and 5.4% respectively. Median survival time (MST was 9.29 moths. COX regression showed clinical stage (P=0.002, ECOG performance status (P=0.000, focus resection (P=0.012 and radiotherapy of primary site (P=0.012 were the independent prognostic factors. Conclusion The elderly patients with NSCLC in early stage and good performance status tend to have longer life expectance, whereas resection and radiotherapy of primary site can prolong the survival time (P<0.05.

  20. Comparison of single-agent chemotherapy and targeted therapy to first-line treatment in patients aged 80 years and older with advanced non-small-cell lung cancer

    Directory of Open Access Journals (Sweden)

    Zhang QQ

    2015-04-01

    Full Text Available Qianqian Zhang,1 Zhehai Wang,2 Jun Guo,2 Liyan Liu,2 Xiao Han,2 Minmin Li,1 Shu Fang,1 Xiang Bi,1 Ning Tang,1 Yang Liu1 1School of Medicine and Life Sciences, Shandong Academy of Medical Sciences, University of Jinan, 2Department of Oncology, Shandong Cancer Hospital, Jinan, People’s Republic of China Purpose: The aim of this study was to compare single-agent chemotherapy with targeted therapy in initial treatment and to explore a better choice of treatment for patients aged 80 years and older with advanced non-small-cell lung cancer (NSCLC.Patients and methods: A retrospective chart review was conducted for 136 patients aged 80 years and older who were cytopathologically diagnosed and staged as advanced (stage IIIB or IV NSCLC. The patient population was divided into two treatment groups: 78 patients were allocated to the chemotherapy group (group A, pemetrexed or gemcitabine or docetaxel as a single agent, and 60 patients were allocated to another group and received epidermal growth factor-receptor tyrosine-kinase inhibitors (group B, erlotinib or gefitinib as a single agent. The primary end points were overall survival (OS and progression-free survival (PFS, and the secondary end points were response rate, disease-control rate, safety, and quality of life.Results: In group A and group B, respectively, the median PFS was 2 versus 4 months (P=0.013, and the median OS was 8 versus 16 months (P=0.025. The 1- and 2-year survival rates of the two groups were 23.7% (group A, 18 of 76 versus 76.7% (group B, 46 of 60 and 13.2% (group A, ten of 76 versus 10% (group B, six of 60, respectively. The response rate and disease-control rate were 28.9% versus 36.7% (P=0.39 and 57.9% versus 76.7% (P=0.022 in group A and group B, respectively.Conclusion: Elders aged 80 years and over with advanced NSCLC in group B had longer PFS and OS compared with group A. It was well tolerated in group B because of the mild adverse effects. Targeted therapy can be

  1. Obstructive sleep apnea in a Danish population of men and women aged 60-80 years with nocturia

    DEFF Research Database (Denmark)

    Bing, Mette Hornum; Jennum, Poul; Moller, Lars Alling;

    2012-01-01

    The aim of the present study was in a case-control design to evaluate the association between nocturia and obstructive sleep apnea, in men and women who had nocturia ≥ 2 per night (nocturics) compared to those without nocturia (controls).......The aim of the present study was in a case-control design to evaluate the association between nocturia and obstructive sleep apnea, in men and women who had nocturia ≥ 2 per night (nocturics) compared to those without nocturia (controls)....

  2. Epilepsy with onset at over 50 years of age: clinical and electroencephalographic characteristics

    Directory of Open Access Journals (Sweden)

    Glória Maria Almeida Souza Tedrus

    2012-10-01

    Full Text Available Epilepsy in older individuals has an elevated incidence. The objective of the present work was to evaluate the clinical, EEG and brain imaging aspects in patients showing late-onset epilepsy. Fifty-five patients with late-onset epilepsy (older than 50 years were evaluated. They were composed of two groups according to the onset age of the epilepsy seizure (ES: 51-60 (G51-60 and over 60 (G60+ years. Focal ES predominated although they were less frequent in G60+. The occurrence of status epilepticus was high and more frequent in G60+ whereas seizures in series predominated in G51-60. Symptomatic epilepsy was more frequent and the vascular etiology predominated. Epileptiform activity was associated with a greater number of ES, and background activity abnormalities were more frequent in G60+. In conclusion, epilepsy with onset at over 50 was predominantly focal and symptomatic, with a high occurrence of status epilepticus and of seizures in series.

  3. Spectroscopic Confirmation of the Rich z=1.80 Galaxy Cluster JKCS 041 Using the WFC3 Grism: Environmental Trends in the Ages and Structure of Quiescent Galaxies

    CERN Document Server

    Newman, Andrew B; Andreon, Stefano; Treu, Tommaso; Raichoor, Anand; Trinchieri, Ginevra

    2013-01-01

    We present HST/WFC3 imaging and grism spectroscopy of the distant galaxy cluster JKCS041. Our survey yields 98 redshifts whose precision is typically ~20x better than photometric estimates. We confirm that JKCS041 is a rich cluster and derive a redshift z=1.80 via the identification of 19 member galaxies, of which 15 are quiescent. These members are spatially aligned with diffuse X-ray emission seen by Chandra. As JKCS041 is the most distant known cluster with such a large and spectroscopically-confirmed quiescent population, it provides an unique opportunity to study the effect of the environment on galaxy properties at early epochs. We construct composite spectra of the quiescent members that clearly reveal Balmer and metallic absorption lines. From these, we infer that the more massive members (log M*>11) have a mean stellar age of 1.4+0.3-0.2 Gyr, whereas lower-mass examples (log M*=10.5-11) have a younger mean age of 0.9+0.2-0.1 Gyr. These ages agree closely with those inferred by Whitaker et al. for sim...

  4. Hemoglobin concentrations in 358 apparently healthy 80-year-old Danish men and women. Should the reference interval be adjusted for age?

    DEFF Research Database (Denmark)

    Milman, N.; Pedersen, A.N.; Ovesen, L.

    2008-01-01

    -year-olds. Methods: Participants in this epidemiological health survey cohort were 358 subjects (171 men) 80 years of age. A dietary survey was performed in 232 subjects. Blood samples included Hb, red cell indices, serum ferritin, serum C-reactive protein, renal and hepatic function tests. Normality...... criteria for Hb were: 1) values in all participants; 2) values in apparently healthy subjects; 3) values in 10-year survivors. Hb was compared with muscle strength, physical performance and diet. Results: In the entire series, median Hb was 140 g/L, 5-95 percentile 116-160 g/L in men, and 131 g/L, 5......-95 percentile 114-147 g/L in women (pmen and 17% in women. Apparently healthy iron-replete men (n=129) and women (n=141) had median Hb of 141 g/L and 131 g/L. Median Hb levels were higher in 10-year surviving...

  5. The HIV Care Cascade Measured Over Time and by Age, Sex, and Race in a Large National Integrated Care System.

    Science.gov (United States)

    Horberg, Michael Alan; Hurley, Leo Bartemeier; Klein, Daniel Benjamin; Towner, William James; Kadlecik, Peter; Antoniskis, Diana; Mogyoros, Miguel; Brachman, Philip Sigmund; Remmers, Carol Louise; Gambatese, Rebecca Claire; Blank, Jackie; Ellis, Courtney Georgiana; Silverberg, Michael Jonah

    2015-11-01

    HIV care cascades can evaluate programmatic success over time. However, methodologies for estimating cascade stages vary, and few have evaluated differences by demographic subgroups. We examined cascade performance over time and by age, sex, and race/ethnicity in Kaiser Permanente, providing HIV care in eight US states and Washington, DC. We created cascades for HIV+ members' age ≥13 for 2010-2012. We measured "linkage" (a visit/CD4 within 90 days of being diagnosed for new patients; ≥1 medical visit/year if established); "retention" (≥2 medical visits ≥60 days apart); filled ART (filled ≥3 months of combination ART); and viral suppression (HIV RNA age, and race/ethnicity. We found men had statistically (p age was associated (p care results improved over time, but significant differences exist by patient demographics. Specifically, retention efforts should be targeted toward younger patients and blacks; women, blacks, and Latinos require greater ART prescribing.

  6. Hemoglobin concentrations in 358 apparently healthy 80-year-old Danish men and women. Should the reference interval be adjusted for age?

    DEFF Research Database (Denmark)

    Milman, N.; Pedersen, Agnes Nadelmann; Ovesen, Lars

    2008-01-01

    -year-olds. Methods: Participants in this epidemiological health survey cohort were 358 subjects (171 men) 80 years of age. A dietary survey was performed in 232 subjects. Blood samples included Hb, red cell indices, serum ferritin, serum C-reactive protein, renal and hepatic function tests. Normality...... criteria for Hb were: 1) values in all participants; 2) values in apparently healthy subjects; 3) values in 10-year survivors. Hb was compared with muscle strength, physical performance and diet. Results: In the entire series, median Hb was 140 g/L, 5-95 percentile 116-160 g/L in men, and 131 g/L, 5......-95 percentile 114-147 g/L in women (p= 20 had a lower frequency of anemia. There was no correlation between Hb and dietary or supplemental iron intake. In men, Hb was correlated to meat consumption. Conclusions: WHO decision limits for anemia should not be lowered in 80-year-old subjects. "Optimal" Hb...

  7. The validation of a French-language version of the Aging Perceptions Questionnaire (APQ) and its extension to a population aged 55 and over

    LENUS (Irish Health Repository)

    Ingrand, Isabelle

    2012-04-30

    AbstractBackgroundSeveral studies have shown the influence of the perceptions of aging on the cognitive functioning and the mental and physical health of older people. These relationships have not to date been studied in France where validated instruments are lacking. The primary objective of this study was to validate a French-language version of the Aging Perceptions Questionnaire (APQ) in the French general population aged 65 and over. The secondary objective was to study the stability of the dimensions of this instrument among participants aged 55 to 64.MethodsThe study was proposed to the cohort of the Observatoire Régional du Vieillissement (OPREVI) (observatory of aging), located in a small town in Poitou-Charentes (western France). An anonymous questionnaire including the APQ was sent by mail to inhabitants aged 55 and over. The original English language APQ was described with adults aged 65 and older. It has 32 items distributed on 7 dimensions: timeline chronic and cyclical, positive and negative consequences, positive and negative control and emotional representations.Results656 adults participated in this survey (286 men, 370 women). Among those aged 65 and over (n = 394), the seven-factor structure estimated by confirmatory factor analysis was coherent with original findings. Internal consistency as evaluated by Cronbach alpha, was between 0.83 for consequences negative and 0.52 for control negative. Several dimensions were strongly correlated. Among participants aged 55 to 64 (n = 262), the same factorial model yielded an acceptable fit. Multi-group confirmatory factor analysis concluded to approximate factorial invariance between the two age groups with a null delta in comparative fit index.ConclusionThis study among French people aged 65 and over, added further evidence of the multidimensional structure of the French version of the APQ which is superimposed to the dimensions of the original Irish version. The same factorial structure

  8. The validation of a French-language version of the Aging Perceptions Questionnaire (APQ and its extension to a population aged 55 and over

    Directory of Open Access Journals (Sweden)

    Ingrand Isabelle

    2012-04-01

    Full Text Available Abstract Background Several studies have shown the influence of the perceptions of aging on the cognitive functioning and the mental and physical health of older people. These relationships have not to date been studied in France where validated instruments are lacking. The primary objective of this study was to validate a French-language version of the Aging Perceptions Questionnaire (APQ in the French general population aged 65 and over. The secondary objective was to study the stability of the dimensions of this instrument among participants aged 55 to 64. Methods The study was proposed to the cohort of the Observatoire Régional du Vieillissement (OPREVI (observatory of aging, located in a small town in Poitou-Charentes (western France. An anonymous questionnaire including the APQ was sent by mail to inhabitants aged 55 and over. The original English language APQ was described with adults aged 65 and older. It has 32 items distributed on 7 dimensions: timeline chronic and cyclical, positive and negative consequences, positive and negative control and emotional representations. Results 656 adults participated in this survey (286 men, 370 women. Among those aged 65 and over (n = 394, the seven-factor structure estimated by confirmatory factor analysis was coherent with original findings. Internal consistency as evaluated by Cronbach alpha, was between 0.83 for consequences negative and 0.52 for control negative. Several dimensions were strongly correlated. Among participants aged 55 to 64 (n = 262, the same factorial model yielded an acceptable fit. Multi-group confirmatory factor analysis concluded to approximate factorial invariance between the two age groups with a null delta in comparative fit index. Conclusion This study among French people aged 65 and over, added further evidence of the multidimensional structure of the French version of the APQ which is superimposed to the dimensions of the original Irish version. The same

  9. 320 Gb/s Single polarization OTDM Transmission over 80 km Standard Transmission Fiber

    DEFF Research Database (Denmark)

    Siahlo, Andrei; Seoane, Jorge; Clausen, Anders;

    2005-01-01

    Optical time-division multiplexing (OTDM) is an attractive technique for increasing the capacity of optical transmission systems. 320 Gbit/s single-channel and single-polarization error-free transmission over continuous spans of either 80 km SMF or 77 km NZDSF are realized.......Optical time-division multiplexing (OTDM) is an attractive technique for increasing the capacity of optical transmission systems. 320 Gbit/s single-channel and single-polarization error-free transmission over continuous spans of either 80 km SMF or 77 km NZDSF are realized....

  10. The relationship between 6-sulphatoxymelatonin and polysomnographic sleep in good sleeping controls and wake maintenance insomniacs, aged 55-80 years.

    Science.gov (United States)

    Lushington, K; Dawson, D; Kennaway, D J; Lack, L

    1999-03-01

    The pineal hormone, melatonin, is reported to possess hypnotic properties. This has led to an investigation of the relationship between the endogenous melatonin rhythm and sleep. However, this relationship has yet to be fully examined in aged insomniacs and controls. From media advertisements, 16 good sleeping controls (11F, 5M) and 16 sleep maintenance insomniacs (11F, 5M), aged over 55 years, were recruited to participate in a study involving four nights of polysomnographically (PSG) measured sleep followed by a 26 h constant routine. During the constant routine, 2 h urine samples were collected and analysed for the melatonin metabolite, 6-sulphatoxymelatonin (aMT.6S). This was used to determine total melatonin excretion. As well, the following circadian melatonin parameters were calculated from fifth order polynomial curve fitting analyses, the goodness of the polynomial curve fit, peak melatonin concentration, the phase of the melatonin rhythm, and melatonin and sleep rhythm synchrony. Apart for one control, all subjects showed significant circadian melatonin rhythms. Although insomniacs showed a greater amount of wakefulness, less sleep in total, and lower sleep efficiency, no significant group differences were observed in any of the melatonin parameters. In addition, while subjects with more reliable melatonin curve fits showed shorter sleep latencies and higher sleep efficiencies, correlational analyses revealed no other significant relationships between any melatonin and PSG sleep parameters. Overall, the present results suggest that neither melatonin amplitude nor phase are related to sleep quality in the aged.

  11. Chemical fingerprint and impact of shipping emissions over a western Mediterranean metropolis: Primary and aged contributions

    Energy Technology Data Exchange (ETDEWEB)

    Pey, Jorge, E-mail: jorge.pey@univ-amu.fr [Institute of Environmental Assessment and Water Research, IDÆA-CSIC, 08034 Barcelona (Spain); Aix-Marseille Université, CNRS, LCE FRE 3416, 13331 Marseille (France); Department of Epidemiology, Lazio Region, 00198 Roma (Italy); Pérez, Noemí [Institute of Environmental Assessment and Water Research, IDÆA-CSIC, 08034 Barcelona (Spain); Department of Epidemiology, Lazio Region, 00198 Roma (Italy); Cortés, Joaquim [Autoriat Portuaria de Barcelona, 08002 Barcelona (Spain); Alastuey, Andrés; Querol, Xavier [Institute of Environmental Assessment and Water Research, IDÆA-CSIC, 08034 Barcelona (Spain)

    2013-10-01

    An intensive monitoring campaign was carried out in the harbor of Barcelona (Spain) to quantify the contribution of primary shipping emissions (PSE) on PM{sub 10}. Chemical composition of inorganic species, as well as OC and EC, was completed, and a source apportionment analysis by Positive Matrix Factorization was conducted. Among the 6 sources extracted, two were linked to harbor emissions: dusty materials released in different areas along the harbor and fuel–oil combustion. On average, harbor emissions accounted for 31% of the PM{sub 10} mass. Since the chemical signature of PSE was not determined neither their contribution was obtained, additional approaches were followed and mainly consisted in: 1) the evaluation of V/Ni and V/Cu ratios to identify those days affected by PSE; 2) the identification of the chemical components increasing under the influence of PSE; 3) the calculation of the daily and average PSE from their experimentally-determined chemical signature and the experimental concentrations of vanadium. As a result, the contribution of PSE was estimated in 0.84 μg m{sup −3} (2.7% of PM{sub 10}) and the residual fuel–oil combustion factor (3.6 μg m{sup −3}, 12% of PM{sub 10}) was interpreted as aged shipping emissions. The present study splits the contribution of shipping emissions into primary and aged, and highlights the importance of atmospheric mixing and aging processes in western Mediterranean atmospheres. In the case of shipping emissions, the aged products were found to be dominant with respect to the primary ones even in the vicinity of the source. Highlights: • Primary and aged shipping emissions were quantified. • An experimental chemical profile for primary shipping emissions is provided. • Aged shipping emissions prevailed even in the proximity of the emission source.

  12. 肠内营养支持在80岁以上反复肺部感染患者中的应用%Clinical application of enteral nutrition support in patients aged over 80 years with recurrent pulmonary infection

    Institute of Scientific and Technical Information of China (English)

    吴宁; 黄方; 齐玉琴; 陈雪松; 张兴虎; 万文辉; 钱晓明

    2012-01-01

    Objective To investigate clinical value of enteral nutrition support in elderly patients with recurrent pulmonary infection. Methods The application of enteral nutrition support in 34 cases of elderly patients with recurrent pulmonary infection were analyzed, 18 patients were treated with percutaneous endoscopic gastrostomy/jejunostomy (PEG/J) , another 16 patients used nasogastric tube. Both groups took equal calories and nitrogen, and nutritional support time was more than 2 months. Results After enteral nutrition support, nutritional status of all patients was improved. There was no significant difference between two groups. However, the frequency of reflux, aspiration, and aspirated pneumonia occurred in PEG/J group was obviously less than those in nasogastric tube group, and the difference between two groups was significant (F<0. 05). Conclusions Appropriate way of enteral nutrition in elderly patients with recurrent pulmonary infection can not only improve the nutritional status, but also reduce the incidence of pulmonary infection, and the immune function could be improved, and then promote the rehabilitation of patients.%目的 探讨肠内营养支持在≥80岁反复肺部感染患者中的临床应用效果. 方法 对34例≥80岁反复肺部感染患者肠内营养支持情况进行分析.采用经皮内镜下胃造瘘术(PEG/J)治疗组18例,采用鼻胃管治疗组16例,摄入同等热量和同等氮量,营养支持时间>2月. 结果 经肠内营养支持后,全部患者的营养状况得到改善,2组各指标差异无显著性.PEG/J治疗组反流、误吸、吸入性肺炎的发生次数均明显少于鼻胃管组,对比差异均有统计学意义(P<0.05). 结论 在≥80岁反复肺部感染患者中选择合适的肠内营养支持方式,不仅可以改善病人的营养状况,还可以减少肺部感染的发生,提高机体免疫功能,促进病人的康复.

  13. Clinical analysis of pulmonary infection with multiple pathogenic bacteria complicated with multiple organ dysfunction syndrome in the patients aged over 80%80岁以上老年多种致病菌肺部感染合并多器官功能不全综合征的临床分析

    Institute of Scientific and Technical Information of China (English)

    方放; 齐玉琴; 万文辉; 钱晓明

    2011-01-01

    Objective To investigate the current situation and strategy of pulmonary infection with multiple pathogenic bacteria complicated by multiple organ dysfunction syndrome in the elderly(MODSE). Methods Clinical data of 32 cases with pulmonary infection complicated by MODSE from August 2005 to August 2009 in our hospital were analyzed retrospectively. Results Among the 32 cases of patients,25 cases showed lung failure first, 5 cases showed kidney failure first, and 2 cases showed heart failure first; The main pathogenic bacteria was pseudomonas aeruginosa,stenotrophomonas maltophilia, staphylococcus aureus, baumanii, and so on. Hospital acquired pneumonia accounted for 90. 6%, communityacquired pneumonia accounting for 9.4%. Mortality was related to the numerus of the number of organ failure and pathogenic bacteria. Conclusions Pathogenic infection in the elderly complicated with MODSE was often associated with multiple bacteria. The main pathogens of hospital acquired pneumonia were pseudomonas aeruginosa. The early control of infection and risk factors, nutritional support and immune therapy to improve disease resistance plays an important role in controlling MODSE and improving the prognosis.%目的 探讨≥80岁老年多种致病菌肺部感染并发多器官功能不全综合征(MODSE)的现状和对策.方法对本院2005年8月至2009年8月32 例≥80岁老年多种致病菌肺部感染并发MODSE患者的临床资料进行回顾性分析.结果 32例≥80岁老年多种致病菌肺部感染并发MODSE患者中,2种致病菌12例,3种致病菌16例,4种致病菌3例,5种致病菌1例.其中院内获得性肺炎占90.6%,社区获得性肺炎占9.4%,院内获得性肺炎主要致病菌以铜绿假单胞菌为主.病死率与累及的衰竭器官数和致病菌种数相关.结论≥80岁老年肺部感染并发MODSE患者常合并多种致病菌,早期控制感染、控制危险因素、给予营养支持和免疫治疗以提高抗病能力对阻止MODSE进

  14. ADL abilities and vocational competencies: Blue-collar workers aged 45 years and over.

    Science.gov (United States)

    Kikuchi, E

    1995-01-01

    A questionnaire composed of 55 items that addressed activities of daily living (ADL) abilities and 13 basic vocational competencies, such as memory and muscular power, was completed by 48 nondisabled male workers aged ≥45 years. The workers were all engaged in the manufacturing industry. All respondents found the following five tasks easy to do: wring a towel, put arms through sleeves, open and shut a door, turn a tap on and off, and open and shut a sliding door. Among basic vocational competencies, the highest performance, with but a small standard deviation, occurred with the muscular power competency; a low performance with a large standard deviation (P=0.05) occurred with concentration. No age difference was discerned in planning ability, cooperativeness, muscular power, staying power, manual adeptness, and sense of equilibrium, whereas in learning ability, agility, and concentration, people aged ≥65 years showed significantly lower performance (P=0.05). The characteristics of vocational competencies in manufacturing industry workers aged ≥45 years were fond to be linked to ADL abilities, and the effectiveness of the ADL abilities survey, prepared on an experimental basis, was confirmed for the evaluation of vocational competencies.

  15. Over 80% Lead Battery Enterprises Closed Down or Suspended Operation

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    <正>It is reported that by July 31st,a total of 1930 enterprises engaged in the production,assembly and recycling (secondary lead) of lead battery products across the nation have received investigation.Wherein,583 were outlawed and closed down,405 were suspended for rectifica

  16. National Trends in the Adoption of Laparoscopic Cholecystectomy over 7 Years in the United States and Impact of Laparoscopic Approaches Stratified by Age

    Directory of Open Access Journals (Sweden)

    Anahita Dua

    2014-01-01

    Full Text Available Introduction. The aim of this study was to characterize national trends in adoption of laparoscopic cholecystectomy and determine differences in outcome based on type of surgery and patient age. Methods. Retrospective cross-sectional study of patients undergoing cholecystectomy. Trends in open versus laparoscopic cholecystectomy by age group and year were analyzed. Differences in outcomes including in-hospital mortality, complications, discharge disposition, length of stay (LOS, and cost are examined. Results. Between 1999 and 2006, 358,091 patients underwent cholecystectomy. In 1999, patients aged80 years had the lowest rates of laparoscopic cholecystectomy, followed by those aged 65–79, 64–50, and 49–18 years (59.7%, 65.3%, 73.2%, and 83.5%, resp., P<0.05. Laparoscopic cholecystectomy was associated with improved clinical and economic outcomes across all age groups. Over the study period, there was a gradual increase in laparoscopic cholecystectomy performed among all age groups during each year, though elderly patients continued to lag significantly behind their younger counterparts in rates of laparoscopic cholecystectomy. Conclusion. This is the largest study to report trends in adoption of laparoscopic cholecystectomy in the US in patients stratified by age. Elderly patients are more likely to undergo open cholecystectomy. Laparoscopic cholecystectomy is associated with improved clinical outcomes.

  17. National Trends in the Adoption of Laparoscopic Cholecystectomy over 7 Years in the United States and Impact of Laparoscopic Approaches Stratified by Age

    Science.gov (United States)

    Aziz, Abdul; Desai, Sapan S.; McMaster, Jason

    2014-01-01

    Introduction. The aim of this study was to characterize national trends in adoption of laparoscopic cholecystectomy and determine differences in outcome based on type of surgery and patient age. Methods. Retrospective cross-sectional study of patients undergoing cholecystectomy. Trends in open versus laparoscopic cholecystectomy by age group and year were analyzed. Differences in outcomes including in-hospital mortality, complications, discharge disposition, length of stay (LOS), and cost are examined. Results. Between 1999 and 2006, 358,091 patients underwent cholecystectomy. In 1999, patients aged80 years had the lowest rates of laparoscopic cholecystectomy, followed by those aged 65–79, 64–50, and 49–18 years (59.7%, 65.3%, 73.2%, and 83.5%, resp., P < 0.05). Laparoscopic cholecystectomy was associated with improved clinical and economic outcomes across all age groups. Over the study period, there was a gradual increase in laparoscopic cholecystectomy performed among all age groups during each year, though elderly patients continued to lag significantly behind their younger counterparts in rates of laparoscopic cholecystectomy. Conclusion. This is the largest study to report trends in adoption of laparoscopic cholecystectomy in the US in patients stratified by age. Elderly patients are more likely to undergo open cholecystectomy. Laparoscopic cholecystectomy is associated with improved clinical outcomes. PMID:24790759

  18. Lifetime income and old age mortality risk in Italy over two decades

    NARCIS (Netherlands)

    Belloni, Michele; Alessie, Rob; Kalwij, Adriaan; Marinacci, Chiara

    2013-01-01

    BACKGROUND The evidence on the shape and trend of the relationship between (lifetime) income and old age mortality is scarce and mixed both for North American and European countries. Nationwide evidence for Italy does not exist yet. OBJECTIVE We investigate the shape and evolution of the association

  19. AIDS in adults 50 years of age and over: characteristics, trends and spatial distribution of the risk

    Directory of Open Access Journals (Sweden)

    Jordana de Almeida Nogueira

    2014-06-01

    Full Text Available OBJECTIVE: to analyze the sociodemographic characteristics, epidemic trend and spatial distribution of the risk of AIDS in adults 50 years of age and over.METHOD: population-based, ecological study, that used secondary data from the Notifiable Disease Information System (Sinan/AIDS of Paraíba state from the period January 2000 to December 2010.RESULTS: during the study period, 307 cases of AIDS were reported among people 50 years of age or over. There was a predominance of males (205/66, 8%, mixed race, and low education levels. The municipalities with populations above 100 thousand inhabitants reported 58.5% of the cases. There was a progressive increase in cases among women; an increasing trend in the incidence (positive linear correlation; and an advance in the geographical spread of the disease, with expansion to the coastal region and to the interior of the state, reaching municipalities with populations below 30 thousand inhabitants. In some locations the risk of disease was 100 times greater than the relative risk for the state.CONCLUSION: aging, with the feminization and interiorization of the epidemic in adults 50 years of age and over, confirms the need for the induction of affirmative policies targeted toward this age group.

  20. The National Treatment Improvement Evaluation Study (NTIES): Profile of Clients Age 45 and Over.

    Science.gov (United States)

    Caliber Associates, Fairfax, VA.

    This paper summarizes similarities and differences between two cohorts of the National Treatment Improvement Evaluation Study (NTIES) clients, those age 45 or older and those younger than 45. Results reveal the following: Clients in the 45+ cohort were considerably more likely to be treated for problems with alcohol or with heroin, and they were…

  1. [Risk factors of serious bleeding among ambulatory patients taking antivitamin K aged 75 and over].

    Science.gov (United States)

    Blas-Châtelain, C; Chauvelier, S; Foti, P; Debure, C; Hanon, O

    2014-05-01

    The benefits of anti-vitamin K (AVK) drugs have been acknowledged in several indications. Such indications increasing with increasing age, AVK prescriptions also increases with age. At the same time, conditions involving significant bleeding are common in this elderly population. It is thus essential to recognize the determining factors. This study included all patients taking AVK drugs aged 75 years and older who sought emergency care at the Cochin Hospital from January to December 2011 for significant bleeding. These patients were compared with a cohort of patients aged 75 years or older who were taking AVK drugs and who were admitted to the same unit during the same time period for other reasons. The case-control comparison included demographic data, comorbidity factors, multiple medications, emergency measured INR, and CHA2DS2VASC level. The hemorrhagic risk was evaluated by HEMORR2HAGES and HAS-BLED. A total of 34 patients were studied and compared with 70 case-controls. The Charlson comorbidity index was higher in patients than case-controls (PAVK drugs is related to their higher comorbidity and hemorrhagic levels which need to be evaluated before starting or stopping AVK treatment.

  2. Maxillofacial injuries and dental trauma in patients aged 19-80 years, Recife, Brazil Lesiones maxilofaciales y traumatismo dental en pacientes de 19 a 80 años, Recife, Brasil

    OpenAIRE

    2010-01-01

    Aim: A retrospective study was undertaken to assess causes of maxillofacial trauma in Recife, Pernambuco, Brazil. Method: A review of 186 patients with maxillofacial injuries aged 19 and 83 years old seen and treated at the Hospital da Restauração between January and December 2006 was conducted and were analyzed according to age, sex, etiology, site of fracture, dentoalveolar trauma and alcohol abuse. Analysis was made in Epi Info using the Chi-square and Fisher´s Exact Tests. Results: It was...

  3. Act your (old) age: prescriptive, ageist biases over succession, consumption, and identity.

    Science.gov (United States)

    North, Michael S; Fiske, Susan T

    2013-06-01

    Perspectives on ageism have focused on descriptive stereotypes concerning what older people allegedly are. By contrast, we introduce prescriptive stereotypes that attempt to control how older people should be: encouraging active Succession of envied resources, preventing passive Consumption of shared resources, and avoidance of symbolic, ingroup identity resources. Six studies test these domains, utilizing vignette experiments and simulated behavioral interactions. Across studies, younger (compared with middle-aged and older) raters most resented elder violators of prescriptive stereotypes. Moreover, these younger participants were most polarized toward older targets (compared with middle-aged and younger analogues)--rewarding elders most for prescription adherences and punishing them most for violations. Taken together, these findings offer a novel approach to ageist prescriptions, which disproportionately target older people, are most endorsed by younger people, and suggest how elders shift from receiving the default prejudice of pity to either prescriptive resentment or reward.

  4. Modelling the chemically aged and mixed aerosols over the eastern central Atlantic Ocean-potential impacts

    NARCIS (Netherlands)

    Astitha, M.; Kallos, G.; Spyrou, C.; O'Hirok, W.; Lelieveld, J.; Denier Gon, H.A.C. van der

    2010-01-01

    Detailed information on the chemical and physical properties of aerosols is important for assessing their role in air quality and climate. This work explores the origin and fate of continental aerosols transported over the Central Atlantic Ocean, in terms of chemical composition, number and size dis

  5. Chemically aged and mixed aerosols over the Central Atlantic Ocean - Potential impacts

    NARCIS (Netherlands)

    Astitha, M.; Kallos, G.; Spyrou, C.; O'Hirok, W.; Lelieveld, J.; Denier Gon, H.A.C. van der

    2010-01-01

    Detailed information on the chemical and physical properties of aerosols is important for assessing their role in air quality and climate. This work explores the origin and fate of continental aerosols transported over the Central Atlantic Ocean, in terms of chemical composition, number and size dis

  6. Effects of Swallowing Training Combined with Real-time Electrical Stimulation on Dysphagia after Stroke in Patients Aged over 80%吞咽训练与实时电刺激结合治疗80岁以上老年人脑卒中后吞咽障碍

    Institute of Scientific and Technical Information of China (English)

    刘立明; 瓮长水; 贾建军; 王娜; 聂永慧

    2010-01-01

    目的 探讨吞咽训练与实时电刺激结合治疗80岁以上老年人脑卒中后的吞咽障碍的疗效.方法 17例80岁以上脑卒中后吞咽障碍的患者采用Vocastim吞咽言语诊治仪进行吞咽训练与实时电刺激结合治疗.治疗前后采用洼田氏饮水试验、吞咽障碍程度分级、吞咽能力评价方法和适应性系数α值进行评价.结果 治疗20次后患者的洼田氏饮水试验、吞咽障碍程度分级、吞咽能力评价方法和适应性系数均有显著改善(P<0.001).结论 吞咽训练与实时电刺激结合治疗可改善高龄老年脑卒中后吞咽障碍患者的吞咽能力.

  7. Development of health over four years among middle-aged and older Europeans

    DEFF Research Database (Denmark)

    Vestergaard, Sonja; Eriksen, Mette Lindholm; Andersen-Ranberg, Karen

    2013-01-01

    Older adults in Eastern and Central European countries have a higher risk of developing poor self-rated health over four years. The same geographical pattern is seen for a higher risk of developing hypertension and diabetes. Low educational level significantly increases the risk of developing poor...

  8. A longitudinal study of gender differences in depressive symptoms from age 50 to 80

    DEFF Research Database (Denmark)

    Barefoot, J C; Mortensen, Erik Lykke; Helms, M J;

    2001-01-01

    The Obvious Depression Scale was administered to 739 community residents at ages 50, 60, and 80 years, with 151 present at all waves. Although selective attrition influenced the level of depressive symptoms in cross-sectional vs. longitudinal samples, both sets of analyses revealed higher scores ...

  9. Aptidão funcional de mulheres idosas ativas com 80 anos ou mais Functional fitness of elderly active women aged 80 or more

    Directory of Open Access Journals (Sweden)

    Camila Peter Hoefelmann

    2011-03-01

    Full Text Available O objetivo deste estudo foi verificar a aptidão funcional de 40 idosas com 80 anos ou mais, praticantes de atividade física de Florianópolis/SC. A aptidão funcional foi verificada por meio dos testes físicos da bateria AAHPERD. Para análise estatística utilizou-se médias, desvio-padrão, amplitude de variação e percentis. A média de idades das idosas foi de 81,9±2,6 anos. O desempenho das idosas foi 55,5±13,5 centímetros para flexibilidade; 15,2±4,3 segundos para coordenação; 31,0±8,5 segundos para agilidade; 19,5±4,2 repetições para resistência de força e 626,9±98,3 segundos para resistência aeróbia. As idosas a partir de 80 anos apresentam menor aptidão funcional, característico do processo de envelhecimento.The objective of this study was to verify the functional fitness of 40 physically active elderly women aged 80 years and over from the city of Florianópolis, SC, Brazil. Their functional fitness was determined by means of the AAHPERD motor function test battery. Statistical analyses were performed using mean, standard desviation, range of variation and percentiles. The mean women elderly aged was 81,9±2,6 years. The performances were: 55.5±13.5 centimeters for the flexibility test; 15.2±4.3 seconds for coordination; 31.0±8.5 seconds for agility; 19.5±4.2 repetitions for strength endurance and 626.9±98.3 seconds for aerobic endurance. The elderly women aged 80 have lower functional fitness, characteristic of the aging process.

  10. The Asian monsoon over the past 640,000 years and ice age terminations

    Science.gov (United States)

    Cheng, Hai; Edwards, R. Lawrence; Sinha, Ashish; Spötl, Christoph; Yi, Liang; Chen, Shitao; Kelly, Megan; Kathayat, Gayatri; Wang, Xianfeng; Li, Xianglei; Kong, Xinggong; Wang, Yongjin; Ning, Youfeng; Zhang, Haiwei

    2016-06-01

    Oxygen isotope records from Chinese caves characterize changes in both the Asian monsoon and global climate. Here, using our new speleothem data, we extend the Chinese record to cover the full uranium/thorium dating range, that is, the past 640,000 years. The record’s length and temporal precision allow us to test the idea that insolation changes caused by the Earth’s precession drove the terminations of each of the last seven ice ages as well as the millennia-long intervals of reduced monsoon rainfall associated with each of the terminations. On the basis of our record’s timing, the terminations are separated by four or five precession cycles, supporting the idea that the ‘100,000-year’ ice age cycle is an average of discrete numbers of precession cycles. Furthermore, the suborbital component of monsoon rainfall variability exhibits power in both the precession and obliquity bands, and is nearly in anti-phase with summer boreal insolation. These observations indicate that insolation, in part, sets the pace of the occurrence of millennial-scale events, including those associated with terminations and ‘unfinished terminations’.

  11. Metabolic rate variation over adult lifetime in the butterfly Vanessa cardui (Nymphalidae: Nymphalinae): aging, feeding, and repeatability.

    Science.gov (United States)

    Woods, William A; Wood, C A L; Ebersole, John; Stevenson, R D

    2010-01-01

    Questions about the adaptive importance of metabolic rate can be approached only when measurements of differences between individuals are repeatable. We made daily measurements of CO(2) production, body mass, and food uptake over the adult life span of unmated Vanessa cardui kept under constant environmental conditions in both fed and unfed treatments. Mass and CO(2) production generally declined with age in both treatments, though with much day-to-day variability in the fed treatment. For the full samples, metabolic rate was repeatable for the unfed treatment (repeatability r = 0.60) but not for the fed treatment (r = 0.03). Differences between fed and unfed individuals of the same age range were repeatable for the unfed treatment (r = 0.39) but not for the fed treatment (r = -0.20). Removing age effects on CO(2) production yielded still higher repeatability in the unfed treatment (r = 0.83), though not in fed butterflies of the same age range (r = -0.02). However, repeatability of CO(2) production of fed butterflies increased sharply with age, rising to 0.82 for butterflies age 8-10 d. Although food uptake mass was repeatable (r = 0.52), feeding history explained little variation in CO(2) production. We conclude that for V. cardui and possibly for other insects of similar feeding habit, variation in metabolic rate between individuals is best represented by measurements of unfed individuals of the same age or of older fed individuals.

  12. [Therapeutic strategies of atrial fibrillation in patients aged 65 and over. Report of 86 cases].

    Science.gov (United States)

    Jaafari, Aïcha; Zakhama, Lilia; Boussabah, Ehlem; Thameur, Moez; Boukhriss, Bessma; Amara, Yosser; Masmoudi, Mourad; Bencheikh, Mamoun; Benyoussef, Soraya

    2004-01-01

    Auricular fibrillation is the most common sustained cardiac arrhythmia, yet the optimal strategy for its management remains unclear. Since the study AFFIRM from which resulted them final were deferred in December 2002, the assumption of responsibility of the fibrillation of the old subject tends to become clarified. 86 patients at least 65 years or more were enrolled in our retrospective study from January 1997 to June 2003. The mean age is 70 years (65 to 82 years) and sex ratio to 0.79. 34% had a history of hypertension and 12% had a coronary artery disease. 2 groups were individualized, according to the year of admission before or after 2002. It comes out from these work 2 points: the restoration of the sinusal rhythm was the first choice. In the event of failure, the option was to maintain fibrillation and this, in the 2 groups. The AVK were founded in the large majority of the cases only after year 2002.

  13. Ice formation and development in aged, wintertime cumulus over the UK: observations and modelling

    Science.gov (United States)

    Crawford, I.; Bower, K. N.; Choularton, T. W.; Dearden, C.; Crosier, J.; Westbrook, C.; Capes, G.; Coe, H.; Connolly, P. J.; Dorsey, J. R.; Gallagher, M. W.; Williams, P.; Trembath, J.; Cui, Z.; Blyth, A.

    2012-06-01

    In situ high resolution aircraft measurements of cloud microphysical properties were made in coordination with ground based remote sensing observations of a line of small cumulus clouds, using Radar and Lidar, as part of the Aerosol Properties, PRocesses And InfluenceS on the Earth's climate (APPRAISE) project. A narrow but extensive line (~100 km long) of shallow convective clouds over the southern UK was studied. Cloud top temperatures were observed to be higher than -8 °C, but the clouds were seen to consist of supercooled droplets and varying concentrations of ice particles. No ice particles were observed to be falling into the cloud tops from above. Current parameterisations of ice nuclei (IN) numbers predict too few particles will be active as ice nuclei to account for ice particle concentrations at the observed, near cloud top, temperatures (-7.5 °C). The role of mineral dust particles, consistent with concentrations observed near the surface, acting as high temperature IN is considered important in this case. It was found that very high concentrations of ice particles (up to 100 L-1) could be produced by secondary ice particle production providing the observed small amount of primary ice (about 0.01 L-1) was present to initiate it. This emphasises the need to understand primary ice formation in slightly supercooled clouds. It is shown using simple calculations that the Hallett-Mossop process (HM) is the likely source of the secondary ice. Model simulations of the case study were performed with the Aerosol Cloud and Precipitation Interactions Model (ACPIM). These parcel model investigations confirmed the HM process to be a very important mechanism for producing the observed high ice concentrations. A key step in generating the high concentrations was the process of collision and coalescence of rain drops, which once formed fell rapidly through the cloud, collecting ice particles which caused them to freeze and form instant large riming particles. The

  14. Ice formation and development in aged, wintertime cumulus over the UK : observations and modelling

    Directory of Open Access Journals (Sweden)

    I. Crawford

    2011-11-01

    Full Text Available In-situ high resolution aircraft measurements of cloud microphysical properties were made in coordination with ground based remote sensing observations of Radar and Lidar as part of the Aerosol Properties, PRocesses And InfluenceS on the Earth's climate (APPRAISE project. A narrow but extensive line (~100 km long of shallow convective clouds over the southern UK was studied. Cloud top temperatures were observed to be higher than ~−8 °C, but the clouds were seen to consist of supercooled droplets and varying concentrations of ice particles. No ice particles were observed to be falling into the cloud tops from above. Current parameterisations of ice nuclei (IN numbers predict too few particles will be active as ice nuclei to account for ice particle concentrations at the observed near cloud top temperatures (~−7 °C. The role of biological particles, consistent with concentrations observed near the surface, acting as potential efficient high temperature IN is considered important in this case. It was found that very high concentrations of ice particles (up to 100 L−1 could be produced by powerful secondary ice particle production emphasising the importance of understanding primary ice formation in slightly supercooled clouds.

    Aircraft penetrations at −3.5 °C, showed peak ice crystal concentrations of up to 100 L−1 which together with the characteristic ice crystal habits observed (generally rimed ice particles and columns suggested secondary ice production had occurred. To investigate whether the Hallett-Mossop (HM secondary ice production process could account for these observations, ice splinter production rates were calculated. These calculated rates and observations could only be reconciled provided the constraint that only droplets >24 μm in diameter could lead to splinter production, was relaxed slightly by 2 μm.

    Model simulations of the case study were also performed with the WRF

  15. Has actuarial aging "slowed" over the past 250 years? A comparison of small-scale subsistence populations and European cohorts.

    Science.gov (United States)

    Gurven, Michael; Fenelon, Andrew

    2009-04-01

    G.C. Williams's 1957 hypothesis famously argues that higher age-independent, or "extrinsic," mortality should select for faster rates of senescence. Long-lived species should therefore show relatively few deaths from extrinsic causes such as predation and starvation. Theoretical explorations and empirical tests of Williams's hypothesis have flourished in the past decade but it has not yet been tested empirically among humans. We test Williams's hypothesis using mortality data from subsistence populations and from historical cohorts from Sweden and England/Wales, and examine whether rates of actuarial aging declined over the past two centuries. We employ three aging measures: mortality rate doubling time (MRDT), Ricklefs's omega, and the slope of mortality hazard from ages 60-70, m'(60-70), and model mortality using both Weibull and Gompertz-Makeham hazard models. We find that (1) actuarial aging in subsistence societies is similar to that of early Europe, (2) actuarial senescence has slowed in later European cohorts, (3) reductions in extrinsic mortality associate with slower actuarial aging in longitudinal samples, and (4) men senesce more rapidly than women, especially in later cohorts. To interpret these results, we attempt to bridge population-based evolutionary analysis with individual-level proximate mechanisms.

  16. Proportional counters aged anode wire recovering using an 80%CF4 + 20%CO2 gas mixture

    CERN Document Server

    Gavrilov, Gennady; Conti, Richard; Fetisov, Andrey; Maysuzenko, Dmitry; Shvecova, Natalia; Vakhtel, Victor

    2011-01-01

    A technique to recover a gas proportional counter having an aged anode wire using a glow discharge in an 80%CF4 + 20%CO2 gas mixture has been developed and tested. Studies of aging effects were carried out under sustained irradiation by an intense 90Sr -source of the straw proportional counters operated with a 60%Ar + 30%CO2 + 10%CF4 gas mixture. Special attention was paid to the aging mechanism of the anode wires. Our experience showed that using a given gas mixture the swelling of the anode wires is a typical mode of aging that leads to degradation of the gas gain. The proposed method of recovery provided a complete restoration of the gas gain and the signal amplitude in the damaged zone of the wire. SEM/XEM analysis confirmed successful cleaning WOx deposits from the wire surface. The application of this method to recover the aged gaseous detectors in real experimental conditions is discussed.

  17. Oral health of individuals aged 3-80 years in Jönköping, Sweden during 30 years (1973-2003). II. Review of clinical and radiographic findings.

    Science.gov (United States)

    Hugoson, Anders; Koch, Göran; Göthberg, Catharina; Helkimo, Anna Nydell; Lundin, Sven-Ake; Norderyd, Ola; Sjödin, Bengt; Sondell, Katarina

    2005-01-01

    The aim of this epidemiological study was to analyze various clinical and radiographic data on oral health and compare the results to those of three cross-sectional studies carried out in 1973 and 1983, and 1993. In 1973, 1983, 1993, and 2003 a random sample of 1,000; 1,104; 1,078; and 987 individuals, respectively, were studied. The individuals were evenly distributed in the age groups 3, 5, 10, 15, 20, 30, 40, 50, 60, 70, and 80 years. In 1973 80-year-olds were not included. All subjects were inhabitants of the City of Jönköping, Sweden. The clinical and radiographic examination assessed edentulousness, removable dentures, implants, number of teeth, caries, restorations and overhangs, oral hygiene, calculus, periodontal status, endodontic treatment, and periapical status. The number of edentulous individuals in the age groups 40-70 years was reduced from 16 per cent in 1973 to 8 per cent in 1993, and to 1 per cent in 2003. The mean number of teeth increased, and up to the age of 60 years, individuals had more or less complete dentitions. During the 30-year period,the number of carious lesions and restorations decreased in general. In the 15-year-olds the decrease in number of restored tooth surfaces was 900 per cent and the corresponding figure for 30-year-olds was 79 per cent. The age groups 60-800 years showed an increase in number of restored tooth surfaces and had as a mean 50 filled tooth surfaces. The oral health among 3-5-year-olds improved markedly between 1973 and 1993. In 2003, however, there was no further improvement in 3- and 5-year-olds compared to 1993. Generally, restorations in 2003 exhibited a high quality and 90-95 per cent had no proximal overhangs. In 1973 this figure was about 60 per cent. In the age groups 20-50 years there were continuously fewer teeth fitted with crowns or bridges during the 30-year period. In 1973 the 50-year-olds had a mean of 24.5 per cent of the teeth crowned and in 2003 6.8 percent. Compared to data from 1973 there

  18. Ice formation and development in aged, wintertime cumulus over the UK: observations and modelling

    Directory of Open Access Journals (Sweden)

    I. Crawford

    2012-06-01

    Full Text Available In situ high resolution aircraft measurements of cloud microphysical properties were made in coordination with ground based remote sensing observations of a line of small cumulus clouds, using Radar and Lidar, as part of the Aerosol Properties, PRocesses And InfluenceS on the Earth's climate (APPRAISE project. A narrow but extensive line (~100 km long of shallow convective clouds over the southern UK was studied. Cloud top temperatures were observed to be higher than −8 °C, but the clouds were seen to consist of supercooled droplets and varying concentrations of ice particles. No ice particles were observed to be falling into the cloud tops from above. Current parameterisations of ice nuclei (IN numbers predict too few particles will be active as ice nuclei to account for ice particle concentrations at the observed, near cloud top, temperatures (−7.5 °C.

    The role of mineral dust particles, consistent with concentrations observed near the surface, acting as high temperature IN is considered important in this case. It was found that very high concentrations of ice particles (up to 100 L−1 could be produced by secondary ice particle production providing the observed small amount of primary ice (about 0.01 L−1 was present to initiate it. This emphasises the need to understand primary ice formation in slightly supercooled clouds. It is shown using simple calculations that the Hallett-Mossop process (HM is the likely source of the secondary ice.

    Model simulations of the case study were performed with the Aerosol Cloud and Precipitation Interactions Model (ACPIM. These parcel model investigations confirmed the HM process to be a very important mechanism for producing the observed high ice concentrations. A key step in generating the high concentrations was the process of collision and coalescence of rain drops, which once formed fell rapidly through the cloud, collecting ice particles which caused them

  19. Osteoporosis, vitamin C intake, and physical activity in Korean adults aged 50 years and over.

    Science.gov (United States)

    Kim, Min Hee; Lee, Hae-Jeung

    2016-03-01

    [Purpose] To investigate associations between vitamin C intake, physical activity, and osteoporosis among Korean adults aged 50 and over. [Subjects and Methods] This study was based on bone mineral density measurement data from the 2008 to 2011 Korean National Health and Nutritional Examination Survey. The study sample comprised 3,047 subjects. The normal group was defined as T-score ≥ -1.0, and the osteoporosis group as T-score ≤ -2.5. The odds ratios for osteoporosis were assessed by logistic regression of each vitamin C intake quartile. [Results] Compared to the lowest quartile of vitamin C intake, the other quartiles showed a lower likelihood of osteoporosis after adjusting for age and gender. In the multi-variate model, the odds ratio for the likelihood of developing osteoporosis in the non-physical activity group significantly decreased to 0.66, 0.57, and 0.46 (p for trend = 0.0046). However, there was no significant decrease (0.98, 1.00, and 0.97) in the physical activity group. [Conclusion] Higher vitamin C intake levels were associated with a lower risk of osteoporosis in Korean adults aged over 50 with low levels of physical activity. However, no association was seen between vitamin C intake and osteoporosis risk in those with high physical activity levels.

  20. Osteoporosis, vitamin C intake, and physical activity in Korean adults aged 50 years and over

    OpenAIRE

    Kim, Min Hee; Lee, Hae-Jeung

    2016-01-01

    [Purpose] To investigate associations between vitamin C intake, physical activity, and osteoporosis among Korean adults aged 50 and over. [Subjects and Methods] This study was based on bone mineral density measurement data from the 2008 to 2011 Korean National Health and Nutritional Examination Survey. The study sample comprised 3,047 subjects. The normal group was defined as T-score ≥ −1.0, and the osteoporosis group as T-score ≤ −2.5. The odds ratios for osteoporosis were assessed by logist...

  1. Maxillofacial injuries and dental trauma in patients aged 19-80 years, Recife, Brazil Lesiones maxilofaciales y traumatismo dental en pacientes de 19 a 80 años, Recife, Brasil

    Directory of Open Access Journals (Sweden)

    A. Leite Cavalcanti

    2010-03-01

    Full Text Available Aim: A retrospective study was undertaken to assess causes of maxillofacial trauma in Recife, Pernambuco, Brazil. Method: A review of 186 patients with maxillofacial injuries aged 19 and 83 years old seen and treated at the Hospital da Restauração between January and December 2006 was conducted and were analyzed according to age, sex, etiology, site of fracture, dentoalveolar trauma and alcohol abuse. Analysis was made in Epi Info using the Chi-square and Fisher´s Exact Tests. Results: It was found that maxillofacial injuries were most frequent in males (89.2% and in the 19-28 year age group (46.8%. Traffic accidents/motorcycle (23.7% and physical violence (20.4% were the most common etiological factor. Facial fractures were detected in 90.9% and a statistically significant difference between sex and facial fracture was found (p = 0.000. The most common facial fracture was maxilla (29.1%, followed by the mandible (27.5%. A positive association between the presence of facial fracture and alcohol consumption was observed (p = 0.002. Dentoalveolar trauma was present in 7.5% of patients. Conclusion: The incidence of facial fractures in Brazilian population is similar than previously reported elsewhere. There were most common in male patients, mainly due to traffic accidents/motorcycle and physical violence.Objetivo: Se llevó a cabo un estudio retrospectivo para evaluar las causas de traumatismo maxilofacial en Recife, Pernambuco, Brasil. Método: Se hizo una revisión de 186 pacientes con lesiones maxilofaciales de 19 a 83 años atendidos y tratados en el Hospital da Restauração entre Enero y Diciembre 2006, analizándoles según edad, sexo, etiología, localización de la fractura, traumatismo dentoalveolar y abuso de alcohol. Se llevó a cabo el análisis en Epi Info, utilizando el Chi cuadrado y la prueba exacta de Fisher. Resultados: Resultó que las lesiones maxilofaciales fueron más frecuentes en los hombres (89,2% y en el grupo de edad

  2. Physical activity and cognitive function in individuals over 60 years of age: a systematic review

    Directory of Open Access Journals (Sweden)

    Carvalho A

    2014-04-01

    Full Text Available Ashley Carvalho,1,2 Irene Maeve Rea,2 Tanyalak Parimon,3,4 Barry J Cusack3,51Department of Public Health, 2School of Medicine, Dentistry and Biomedical Science, Queen’s University Belfast, Northern Ireland, UK; 3Research and Development Service, Veterans Affairs Medical Center, Boise, ID, USA; 4Division of Pulmonary and Critical Care Medicine, 5Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, USABackground: It is unclear whether physical activity in later life is beneficial for maintenance of cognitive function. We performed a systematic review examining the effects of exercise on cognitive function in older individuals, and present possible mechanisms whereby physical activity may improve cognition.Methods: Sources consisted of PubMed, Medline, CINAHL, the Cochrane Controlled Trials Register, and the University of Washington, School of Medicine Library Database, with a search conducted on August 15, 2012 for publications limited to the English language starting January 1, 2000. Randomized controlled trials including at least 30 participants and lasting at least 6 months, and all observational studies including a minimum of 100 participants for one year, were evaluated. All subjects included were at least 60 years of age.Results: Twenty-seven studies met the inclusion criteria. Twenty-six studies reported a positive correlation between physical activity and maintenance or enhancement of cognitive function. Five studies reported a dose-response relationship between physical activity and cognition. One study showed a nonsignificant correlation.Conclusion: The preponderance of evidence suggests that physical activity is beneficial for cognitive function in the elderly. However, the majority of the evidence is of medium quality with a moderate risk of bias. Larger randomized controlled trials are needed to clarify the association between exercise and cognitive function and to determine

  3. [Guide values for heart rate and blood pressure with reference to 20, 40, 60 und 80% of maximum exertion considering age, sex and body mass in non-trained individuals].

    Science.gov (United States)

    Strasser, Barbara; Schwarz, Joachim; Haber, Paul; Schobersberger, Wolfgang

    2011-12-01

    Aim of this study was to evaluate reliable guide values for heart rate (HF) and blood pressure (RR) with reference to defined sub maximum exertion considering age, gender and body mass. One hundred and eighteen healthy but non-trained subjects (38 women, 80 men) were included in the study. For interpretation, finally facts of 28 women and 59 men were used. We found gender differences for HF and RR. Further, we noted significant correlations between HF and age as well as between RR and body mass at all exercise levels. We established formulas for gender-specific calculation of reliable guide values for HF and RR on sub maximum exercise levels.

  4. Clinical analysis of 82 patients with pneumonia over 80-year-old%80岁以上老年肺炎82例临床分析

    Institute of Scientific and Technical Information of China (English)

    郝丽杰; 冯明; 李耘

    2011-01-01

    目的 探讨80岁以上老年肺炎的临床特点.方法 分析82例80岁以上老年肺炎的临床资料.结果 死亡33例(40.2%).对82例患者发现卧床、休克、营养不良和APACHEⅡ和PSI评分较高为影响80岁以上老年人肺炎病死率的独立危险因素.结论 80岁以上老年肺炎患者临床表现症状、体征不典型,肺外症状多,营养不良的患者常见,卧床、休克、营养不良和APACHEⅡ和PSI评分较高为影响80岁以上老年人肺炎病死率的独立危险因素.%Objective To explore the clinical features of the patients with pneumonia over 80-year-old. Methods A retrospective study was carried out to assess the clinical characteristics of 82 patients with pneumonia over 80-year-old. The logistic regression model was used for analyzing the risk factors of mortality. Results A total of 82 patients were included. 33(40. 2% ) patients died. There were three independent risk factors: previous bed confinement, shock, malnutrition, high PSI score and APACHE Q score. Conclusions We conclude that clinical characteristics of pneumonia in the oldest old are untypical and the incidence of malnutrition is very high. Previous bed confinement, shock, malnutrition, high PSI score and high APACHE II score are independent risk factors associated with greater mortality.

  5. CHILD ALLOWANCE FOR CHILDREN AGED 18 AND OVER AND REIMBURSEMENT OF EDUCATION FEES

    CERN Multimedia

    HR Division

    2001-01-01

    Human Resources Division wishes to draw the attention of members of personnel to paragraph 8 of Administrative Circular N° 5 (Dependent Child) and reminds them that if employment is taken up, the child is no longer considered dependent. In particular, the undertaking of teaching activities during the study period can be considered as taking up employment. Human Resources Division also wishes to draw the attention of members of personnel to Article RIV 1.13 of the Regulations and reminds them that the amount of any financial benefits received from outside the Organization shall be deducted from the benefits paid by the Organization in the same area. Grants, allowances and salaries paid to trainees who benefit from the reimbursement of their education fees, will therefore be deducted from the amount paid by CERN.

  6. Falls in advanced old age: recalled falls and prospective follow-up of over-90-year-olds in the Cambridge City over-75s Cohort study

    Directory of Open Access Journals (Sweden)

    Matthews Fiona E

    2008-03-01

    Full Text Available Abstract Background The "oldest old" are now the fastest growing section of most western populations, yet there are scarcely any data concerning even the common problem of falls amongst the very old. Prospective data collection is encouraged as the most reliable method for researching older people's falls, though in clinical practice guidelines advise taking a history of any recalled falls. This study set out to inform service planning by describing the epidemiology of falls in advanced old age using both retrospectively and prospectively collected falls data. Methods Design: Re-survey of over-90-year-olds in a longitudinal cohort study – cross-sectional interview and intensive 12-month follow-up. Participants and setting: 90 women and 20 men participating in a population-based cohort (aged 91–105 years, in care-homes and community-dwelling recruited from representative general practices in Cambridge, UK Measurements: Prospective falls data were collected using fall calendars and telephone follow-up for one year after cross-sectional survey including fall history. Results 58% were reported to have fallen at least once in the previous year and 60% in the 1-year follow-up. The proportion reported to have fallen more than once was lower using retrospective recall of the past year than prospective reports gathered the following year (34% versus 45%, as were fall rates (1.6 and 2.8 falls/person-year respectively. Repeated falls in the past year were more highly predictive of falls during the following year – IRR 4.7, 95% CI 2.6–8.7 – than just one – IRR 3.6, 95% CI 2.0–6.3, using negative binomial regression. Only 1/5 reportedly did not fall during either the year before or after interview. Conclusion Fall rates in this representative sample of over-90-year-olds are even higher than previous reports from octogenarians. Recalled falls last year, particularly repeated falls, strongly predicted falls during follow-up. Similar proportions

  7. Culture of skeletal myoblasts from human donors aged over 40 years: dynamics of cell growth and expression of differentiation markers

    Directory of Open Access Journals (Sweden)

    Cherubino Paolo

    2005-05-01

    Full Text Available Abstract Background Local myogenesis, neoangiogenesis and homing of progenitor cells from the bone marrow appear to contribute to repair of the infarcted myocardium. Implantation into heart tissues of autologous skeletal myoblasts has been associated with improved contractile function in animal models and in humans with acute myocardial ischemia. Since heart infarction is most prevalent in individuals of over 40 years of age, we tested whether culture methods available in our laboratory were adequate to obtain sufficient numbers of differentiated skeletal myoblasts from muscle biopsy specimens obtained from patients aged 41 to 91. Methods and results No matter of donor age, differentiated skeletal muscle cells could be produced in vitro in amounts adequate for cellular therapy (≥300 millions. Using desmin as a cytoplasmic marker, about 50% cultured cells were differentiated along myogenic lineages and expressed proteins proper of skeletal muscle (myosin type I and II, actin, actinin, spectrin and dystrophin. Cytogenetic alterations were not detected in cultured muscle cells that had undergone at least 10 population doublings. Molecular methods employed for the screening of persistent viral infections evidenced that HCV failed to replicate in muscle cells cultured from one patient with chronic HCV infection. Conclusion The proposed culture methods appear to hold promise for aged patients not only in the field of cardiovascular medicine, but also in the urologic and orthopedic fields.

  8. Smoking, antioxidant supplementation and dietary intakes among older adults with age-related macular degeneration over 10 years.

    Directory of Open Access Journals (Sweden)

    Bamini Gopinath

    Full Text Available We aimed to compare the micronutrient usage and other lifestyle behaviors over 10 years among those with and without age-related macular degeneration (AMD. 1612 participants aged 49+ years at baseline were re-examined over 10 years, west of Sydney, Australia. AMD was assessed from retinal photographs. Dietary data were collected using a semi-quantitative food frequency questionnaire. Smoking status was self-reported. 56 participants had any AMD at baseline, of these 25% quit smoking at 5 years and were still not smoking at 10-year follow-up. Among participants who had below the recommended intake of vitamins A, C or E supplements at baseline, those who did compared to those who did not develop late AMD over 10 years were more likely to report vitamins A (total, C or E supplement intake above the recommended intake at 10-year follow-up: multivariable-adjusted OR 4.21 (95% CI 1.65-10.73; OR 6.52 (95% CI 2.76-15.41; and OR 5.71 (95% CI 2.42-13.51, respectively. Participants with compared to without AMD did not appreciably increase fish, fruit and vegetable consumption and overall diet quality. Adherence to smoking and dietary recommendations was poor among older adults with AMD. However, uptake of antioxidant supplements increased significantly among those with late AMD.

  9. Tree Age Effects on Fine Root Biomass and Morphology over Chronosequences of Fagus sylvatica, Quercus robur and Alnus glutinosa Stands.

    Science.gov (United States)

    Jagodzinski, Andrzej M; Ziółkowski, Jędrzej; Warnkowska, Aleksandra; Prais, Hubert

    2016-01-01

    There are few data on fine root biomass and morphology change in relation to stand age. Based on chronosequences for beech (9-140 years old), oak (11-140 years) and alder (4-76 years old) we aimed to examine how stand age affects fine root biomass and morphology. Soil cores from depths of 0-15 cm and 16-30 cm were used for the study. In contrast to previously published studies that suggested that maximum fine root biomass is reached at the canopy closure stage of stand development, we found almost linear increases of fine root biomass over stand age within the chronosequences. We did not observe any fine root biomass peak in the canopy closure stage. However, we found statistically significant increases of mean fine root biomass for the average individual tree in each chronosequence. Mean fine root biomass (0-30 cm) differed significantly among tree species chronosequences studied and was 4.32 Mg ha(-1), 3.71 Mg ha(-1) and 1.53 Mg ha(-1), for beech, oak and alder stands, respectively. The highest fine root length, surface area, volume and number of fine root tips (0-30 cm soil depth), expressed on a stand area basis, occurred in beech stands, with medium values for oak stands and the lowest for alder stands. In the alder chronosequence all these values increased with stand age, in the beech chronosequence they decreased and in the oak chronosequence they increased until ca. 50 year old stands and then reached steady-state. Our study has proved statistically significant negative relationships between stand age and specific root length (SRL) in 0-30 cm soil depth for beech and oak chronosequences. Mean SRLs for each chronosequence were not significantly different among species for either soil depth studied. The results of this study indicate high fine root plasticity. Although only limited datasets are currently available, these data have provided valuable insight into fine root biomass and morphology of beech, oak and alder stands.

  10. Children’s exposures to water and sand at the beach: Findings from studies of over 80,000 subjects at 13 beaches

    Science.gov (United States)

    Swimming and recreating in lakes, oceans, and rivers is common among adults and children; some studies have suggested that children may be at greater risk of illness following such exposures. Such differences might be due to differences in immunity or differing behavioral factors...

  11. 650 Gbit/s OTDM transmission over 80 km SSMF incorporating clock recovery, channel identification and demultiplexing in a polarisation insensitive receiver

    DEFF Research Database (Denmark)

    Galili, Michael; Mulvad, Hans Christian Hansen; Hu, Hao;

    2010-01-01

    Error free low penalty 650 Gbit/s OTDM transmission is demonstrated using a polarisation independent receiver based on FWM for demultiplexing. Spectral shaping in the transmitter and filtering in the receiver are used for clock extraction....

  12. Sex and age trends in Australia's suicide rate over the last decade: Something is still seriously wrong with men in middle and late life.

    Science.gov (United States)

    Burns, Richard A

    2016-11-30

    Despite significant investment in mental health and suicide intervention strategies in Australia, the extent of change in suicide rates over the last decade is unclear. This paper analyses sex and age trajectories in suicide rates over the last decade in Australia. Age Standardized Suicide Rates from 2004 to 2013 were obtained from the Australian Bureau of Statistics and reflect rates of suicide per 100,000 within age and sex cohorts. Age-related suicide rates were consistent over the last decade. For both males and females, there were increases in mid-life suicide rates before declining around 55-65 years of age. However, rates of suicide in men increased in late-life with rates for those aged 70-79 comparable with those in mid-life. Rates amongst men aged 85+ were consistently the highest rates over the decade. Positively, there was decline in suicide rates among younger men aged 20-34 years. However, more consistently, for both sexes across most age cohorts, there were either increases or no change in suicide rate. Apart from declines in younger-adult males, analysis of age-standardized suicide rates indicate no improvement in suicide rates. High suicide rates amongst middle-aged and older males remain a significant public health issue that needs to be addressed.

  13. Psychological need satisfaction and well-being in adults aged 80 years and older living in residential homes: using a self-determination theory perspective.

    Science.gov (United States)

    Ferrand, Claude; Martinent, Guillaume; Durmaz, Neriman

    2014-08-01

    Based on the self-determination theory (SDT), this study aims to examine the psychological needs satisfaction of the elderly living in residential homes and their relationship with indicators of well-being, and then to test the contribution of each need on these indicators. Participants (N=100; Mage=86.7 years, SD=3.78) completed the measures of psychological needs satisfaction, purpose in life, personal growth and geriatric depression. Cluster analyses showed two distinct profiles: one profile with a high satisfaction of the three basic psychological needs and another profile with a low satisfaction of the three basic psychological needs. These profiles did not differ in terms of residents' characteristics, health problems and functional limitations. Multivariate analysis of variance (MANOVA) results revealed that the participants with the profile of a high satisfaction of psychological needs have significantly higher levels of purpose in life and personal growth than participants with the profile of a low satisfaction of psychological needs, and no effect of cluster membership on depressive feelings was reported. Moreover, for all participants, relatedness need satisfaction was significantly and positively related to personal growth, and autonomy and relatedness needs satisfaction was related to purpose of life. In conclusion, our results offer evidence that old age can be fruitful and, in consistent with SDT, show that autonomy and relatedness need satisfaction is positively associated with indicators of well-being such as purpose in life and personal growth, considered as essential components of optimal functioning.

  14. [The age of Gutenberg is over: a consideration of medical education--past, present and future].

    Science.gov (United States)

    Burg, G; French, L E

    2012-04-01

    Education is the basis for reliable medical care and medical progress. Our medical knowledge has increased more in the past 50 years than in the 500 years before. The spatial and human resource capacity of our universities cannot cope with the existing academic structures and needs. Part of the problem can be solved by "blended learning", that is a combination of traditional teaching methods (frontal lectures, courses, bedside teaching) with supplementary web-based e-learning. In addition to conveying a sound basic knowledge, the ability to cope with modern media and prepare for lifelong learning must also be taught. Out of the large number of e-learning platforms for undergraduate students offered in the internet, we present the program DOIT (Dermatology Online with Interactive Technology; http://www.swisdom.org) and the program Dermokrates (http://www.Dermokrates.com) of the German, Austrian and Swiss Dermatological Societies for postgraduate Continuing Medical Education (CME). The biggest obstacle in the implementation of new developments is the stubborn adherence to traditional structures.

  15. Urinary Incontinence, Related Factors and Depression among 20 Aged and Over Women in Beylikova District Centre in Eskisehir

    Directory of Open Access Journals (Sweden)

    Alaettin Unsal

    2013-06-01

    Full Text Available Aim: To determination of prevalence of Urinary incontinence (UI, and to evaluation of relationship between UI and depression in women. Material and methods: This study is a cross-sectional type research, was realized between 05 July 2011 to 25 August 2011, among 20 and over aged women that living in Beylikova district centre. The study group was occurred 500 women. The presence of UI, its type and severity were evaluated according to criteria recommended by the International Continence Society. For the purpose of the questionnaire form prepared by the study, households were visited one by one, filled with face to face method. Beck Depression Inventory (BDI was used for evaluation of depression. Chi-square test and Logistic Regression Analyses were used in statistical analyses. For statistical significance, p<0.05 were approved. Results: The ages of women were between 20 to 81 years, and average age was 46.97±15.65 years. Prevalence of UI was found 41.4% (n=207. Of the UI cases were 35.7% stress incontinence, 15.5% urge incontinence, 48.8% mixed type. Of the cases were 95 (45.9% low severity, 60 (29.0% middle severity, 52 (25.1% high severity. In this study, UI was an important risk factor in illiterates (OR: 6.617, no smoking (OR: 1.868, obes (OR: 2.777, persons with anyone chronicle disease that diagnosed by doctor (OR: 4.711, enuresis nocturna hystory in childhood age (OR: 2.600, large baby history in women who had given birth (OR: 1.947, and menopause (OR: 2.497. Prevalence of depression was found 25.4% (n=127. Prevalence of depression was higher found in the women with UI, stress type UI, and high severity UI (for each one; p<0.05. Conclusion: In this study, it was determinate that UI an important health problem in the women, and depression prevalence was higher in the women with UI. [TAF Prev Med Bull 2013; 12(3.000: 231-242

  16. Liver Transplantation Outcomes Using Grafts From Donors Older Than the Age of 80 Years.

    Science.gov (United States)

    Rabelo, A V; Alvarez, M J; Méndez, C S M; Villegas, M T; MGraneroa, K; Becerra, A; Dominguez, M; Raya, A M; Exposito, M; Suárez, Y F

    2015-11-01

    We performed a retrospective cohort study between 2002 and 2014 to compare liver transplantation outcomes between recipients of grafts from donors older than and younger than the age of 80 years. Numerical variables were compared with the Student t test when their distribution was normal and the Mann-Whitney test when it was not, whereas categorical variables were compared with Pearson chi-squared test or Fisher test, as appropriate; P graft rejection, retransplantation, or survival at 6 months. Although earlier studies considered livers from elderly donors to be suboptimal, our results support the proposition that octogenarian donors can be an excellent source of liver grafts.

  17. Accidente cerebrovascular isquémico en mayores de 80 años Acute ischemic stroke in patients aged 80 or older

    Directory of Open Access Journals (Sweden)

    Juan I Rojas

    2007-12-01

    Full Text Available En los pacientes de edad avanzada, el perfil de factores de riesgo vascular y el subtipo de accidente cerebrovascular (ACV es diferente en comparación con pacientes más jóvenes. El objetivo del presente trabajo fue describir el perfil de factores de riesgo y subtipo de ACV isquémico en nuestra población de pacientes ancianos. Incluimos a pacientes mayores de 80 años con diagnóstico de ACV isquémico y ataque isquémico transitorio (AIT entre junio de 2003 y junio de 2006. De 535 pacientes con eventos cerebrovasculares isquémicos, en 366 casos el diagnóstico fue de ACV y 169 de AIT. El 33.5% (179 pacientes fueron mayores de 80 años. La edad media fue de 84.4 ± 4.4 años. Los factores de riesgo más frecuentes fueron: hipertensión arterial 82.7%, dislipemia 40.2% y fibrilación auricular 24.6%. El subtipo de ACV que se presentó con mayor frecuencia fue la enfermedad de pequeñas arterias en un 41.7%, seguido por el evento cardioembólico en el 19.7%, enfermedad de gran arteria 6%, otras causas en el 0.8%. De los factores de riesgo vasculares tradicionales, los más significativos fueron hipertensión e hipercolesterolemia. Estos datos son coincidentes con estudios epidemiológicos previos y explican la mayor incidencia de infartos lacunares.Young and old age stroke groups have different vascular risk profiles for cerebral ischemic events. The objective of the study was to describe the risk factor profile and stroke subtype in this population of very elderly people. We included patients over 80 years old with diagnosis of ischemic stroke and transient ischemic attack registered between June 2003 and June 2006. We described the demographic data and subtype of ischemic stroke. Of 535 patients with cerebrovascular ischemic events, the final diagnosis was stroke in 366 cases and transient ischemic attack in 169. Of these patients 33.5% were over 80 years old (179. The mean age was 84.4 ± 4.4 years. The most frequent risk factors were

  18. Pregnancy Outcome of Multiparous Women Aged over 40 Years.

    Science.gov (United States)

    Ates, Seda; Batmaz, Gonca; Sevket, Osman; Molla, Taner; Dane, Cem; Dane, Banu

    2013-01-01

    Objective. The aim of this study was to evaluate the effect of maternal age on prenatal and obstetric outcome in multiparaous women. Materials and Methods. A retrospective case control study was conducted, including women aged 40 years and over (study group, n = 97) who delivered at 20 week's gestation or beyond and women aged 20-29 years (control group, n = 97). Results. The mean age of women in the study group was 41.2 ± 1.7 years versus 25.4 ± 2.3 years in the control group. Advanced maternal age was associated with a significantly higher rate of hypertension, diabetes mellitus, fetal complication, and 5-minute Apgar scores <7 (P < 0.05). Caeserean section rate, incidence of placental abruption, preterm delivery, and neonatal intensive care unit admission were more common in the older group, but the differences were not statistically significant. Conclusions. Advanced maternal age is related to maternal and neonatal complications.

  19. Health-Promoting Interventions for Persons Aged 80 and Older Are Successful in the Short TermuResults from the Randomized and Three-Armed Elderly Persons in the Risk Zone Study

    DEFF Research Database (Denmark)

    Gustafsson, S.; Wilhelmson, K.; Eklund, K.;

    2012-01-01

    OBJECTIVES: To examine the outcomes of the Elderly Persons in the Risk Zone study, which was designed to evaluate whether it is possible to delay deterioration if a health-promoting intervention is made when an older adult (>= 80) is at risk of becoming frail and whether a multiprofessional group....... SETTING: Two urban districts of Gothenburg, Sweden. PARTICIPANTS: Four hundred fifty-nine communityliving adults aged 80 and older not dependent on the municipal home help service. INTERVENTION: A preventive home visit or four weekly multiprofessional senior group meetings with one follow-up home visit...... dependence in ADLs (OR = 1.95, 95% CI = 1.14-3.33). No effect on frailty could be demonstrated. CONCLUSION: Health-promoting interventions made when older adults are at risk of becoming frail can delay deterioration in self-rated health and ADLs in the short term. A multiprofessional group intervention...

  20. Health and well being of lesbian, gay, bisexual, transgender and intersex people aged 50 years and over.

    Science.gov (United States)

    Hughes, Mark

    2017-03-07

    Objectives The aim of the present study was to examine the health and well being of older lesbian, gay, bisexual, transgender and intersex (LGBTI) people, the health issues that concern them, the services they use and challenges accessing services.Methods This study comprised a survey of the health and well being of 312 LGBTI people aged 50 years and over in New South Wales. The survey included the Short-Form 12 (SF-12) measure of health-related quality of life, the Kessler 10 (K10) measure of psychological distress, and the three-item Loneliness Scale.Results Higher levels of psychological distress, lower mental health and greater loneliness were found among this sample than is typically found in the general population. Mental health was lower among carers and those not in a relationship, while psychological distress was greater among those living alone and those experiencing higher rates of loneliness. The most commonly accessed health service was a general practitioner (GP), with most respondents reporting that they were open about their sexuality to their GP and that they had a regular GP. Some reported difficulties accessing health services because of their gender or sexual diversity.Conclusions Although many older LGBTI people are well, both physically and mentally, they do appear to face increased risk of certain health issues compared with the general population.What is known about the topic? Overseas research indicates that older LGBTI people may be at greater risk of certain physical and mental health conditions than the general population.What does this paper add? This paper provides Australian data, using well-validated instruments, on the health and well being of older LGBTI people. It provides evidence of the health issues that older LGBTI people are most concerned about and the barriers they face in accessing services.What are the implications for practitioners? It is important for health practitioners to be aware that older LGBTI people appear to be

  1. Cleft deformities in adults and children aged over six years in Nigeria: Reasons for late presentation and management challenges

    Directory of Open Access Journals (Sweden)

    Wasiu L Adeyemo

    2009-11-01

    Full Text Available Wasiu L Adeyemo1, Mobolanle O Ogunlewe1, Ibironke Desalu2, Akinola L Ladeinde1, Bolaji O Mofikoya3, Michael O Adeyemi4, Adegbenga A Adepoju4, Olufemi O Hassan41Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, 2Department of Anaesthesia, 3Department of Surgery, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria; 4Department of Oral and Maxillofacial Surgery, Lagos University Teaching Hospital, Lagos, NigeriaAbstract: In developing countries, untreated cleft lips and palates are found with increasing frequency and patients often present to the surgeon far past the optimal time for closure of the cleft deformities. A prospective study was conducted between March 2007 and September 2009, to identify the reasons and treatment challenges of delayed presentation of cleft lip and palate deformities at the Lagos University Teaching Hospital, Nigeria. Out of a total of 150 patients with cleft defects during the period, 43 (28.7% were adults and children aged over six years. The mean age of these patients at the time of presentation was 17.3 years. The most common reasons for late presentation were lack of money (56.7%, lack of health care services nearby (18.4%, and lack of awareness of treatment availability (13.3%. Common challenges in these patients included surgical, orthodontic, speech, anesthetic, and psychological. Although adult clefts were significantly enlarged in three dimensions the anatomic landmarks were easier to discern than in an infant. However, extensive soft tissue dissection in adult cleft lip repair resulted in significant postoperative edema. Closure of wide palatal cleft often required the use of adjunct intraoral flaps. Despite late presentation, surgical outcome of these patients was satisfactory and comparable to cleft repair in infants.Keywords: cleft deformities, adults, adolescents, late presentation, management, challenges

  2. Fiber-wireless transmission system of 108  Gb/sdata over 80 km fiber and 2×2multiple-input multiple-output wireless links at 100 GHz W-band frequency.

    Science.gov (United States)

    Li, Xinying; Dong, Ze; Yu, Jianjun; Chi, Nan; Shao, Yufeng; Chang, G K

    2012-12-15

    We experimentally demonstrate a seamlessly integrated fiber-wireless system that delivers a 108  Gb/s signal through 80 km fiber and 1 m wireless transport over free space at 100 GHz adopting polarization-division-multiplexing quadrature-phase-shift-keying (PDM-QPSK) modulation and heterodyning coherent detection. The X- and Y-polarization components of the optical PDM-QPSK baseband signal are simultaneously upconverted to 100 GHz wireless carrier by optical polarization-diversity heterodyne beating, and then independently transmitted and received by two pairs of transmitter and receiver antennas, which form a 2×2 multiple-input multiple-output wireless link. At the wireless receiver, two-stage downconversion is performed firstly in the analog domain based on balanced mixer and sinusoidal radio frequency signal, and then in the digital domain based on digital signal processing (DSP). Polarization demultiplexing is realized by the constant modulus algorithm in the DSP part at the receiver. The bit-error ratio for the 108  Gb/s PDM-QPSK signal is less than the pre-forward-error-correction threshold of 3.8×10(-3) after both 1 m wireless delivery at 100 GHz and 80 km single-mode fiber-28 transmission. To our knowledge, this is the first demonstration to realize 100  Gb/s signal delivery through both fiber and wireless links at 100 GHz.

  3. Associations of Physiological Factors, Age, and Sensory Over-Responsivity with Food Selectivity in Children with Autism Spectrum Disorders

    Directory of Open Access Journals (Sweden)

    Michelle A. Suarez Ph.D., OTR/L

    2012-11-01

    Full Text Available PURPOSE: The aim of this study was to investigate the relationship among physiological factors, age, sensory over-responsivity (SOR and food selectivity in children with autism spectrum disorders (ASD.METHODS: One hundred forty-one parents of children with ASD were recruited through a national autism organization, Autism Speaks, to fill out a survey regarding their child’s mealtime behavior. Survey contained items to measure the severity of food selectivity behavior, the presence of physiological factors (i.e., reflux,constipation, food allergies and the need for a specialized diet and sensory over-responsivity (SOR. Results were analyzed using Chi Square, ANOVA and logistic regression.RESULTS: No relationship between physiological factors and level of food selectivity was found. Older children in the 3-9 year old range did not have more foods in their diet repertoire than younger children. Finally, children with fewer than 10 and those with 11-20 foods in their diet (i.e., severe food selectivity and moderate food selectivity respectively were found to have significantly higher scores on a measure of SOR when compared to children with 21+ foods (typical selectivity.CONCLUSIONS: When addressing food selectivity in children with ASD, consideration of the possibility that the child may not outgrow restricted diets is warranted. Also, treatment for food selectivity may be more effective if SOR is included in protocol.

  4. Oral health of individuals aged 3-80 years in Jönköping, Sweden, during 40 years (1973-2013). I. Review of findings on oral care habits and knowledge of oral health.

    Science.gov (United States)

    Norderyd, Ola; Kochi, Göran; Papias, Apostolos; Köhler, Alkisti Anastassaki; Helkimo, Anna Nydell; Brahm, Carl-Otto; Lindmark, Ulrika; Lindfors, Ninita; Mattsson, Anna; Rolander, Bo; Ullbro, Christer; Gerdin, Elisabeth Wárnberg; Frisk, Fredrik

    2015-01-01

    The aim of the this study was to present data on oral care habits and knowledge of oral health in 2013, and to compare these data with results from a series of four previous cross-sectional epidemiological studies. All these studies were carried out in the city of Jönköping, Sweden, in 1973, 1983, 1993, 2003, and 2013. The 1973 study constituted a random sample of 1,ooo individuals evenly distributed in the age groups 3, 5, 10, 15, 20, 30, 40, 50, 60, and 70 years. The same age groups with addition of a group of 80-year-olds were included in the 1983, 1993, 2003, and 2013 studies, which comprised 1,104; 1,078; 987; and 1,010 individuals, respectively. A questionnaire about dental care habits and knowledge of oral health was used. The questionnaire contained the same questions in all the five studies, although some had to be slightly modernised during the 40-year period. During the period 1973-2013, a continous increase of individuals in the age group 20-60 years were treated by the Public Dental Service amounting to about 50%. Almost 70% of the 70- and 80-year-olds were treated by private practitioners. In 2013, 10-20% of the individuals in the age groups 30-40 years did not regularly visit neither Public Dental Service nor a private practitioner. The corresponding figures for the individuals 50-80 years old were 4-7%. Similar number of avoidance was reported in the previous studies. In the survey 2013, about 20-30% of the individuals in the age groups 20-50 felt frightened, sick, or ill at ease at the prospect of an appointment with the dentist. These findings were in agreement with the results from the surveys 1973-2003. Among the younger age groups, 0-15 years, a reduction in self-reported "ill at ease" was found in the surveys 2003 and 2013 compared to the previous surveys in this series. In 2013, the knowledge of the etiology of caries was known by about 60% of the individuals which was similar to that reported 1973-2003. Twenty per cent of the individuals

  5. Full-duplex transmission of 256-QAM WiMAX signals over an 80-km long-reach PON

    DEFF Research Database (Denmark)

    Prince, Kamau; Osadchiy, Alexey Vladimirovich; Tafur Monroy, Idelfonso

    2009-01-01

    We present bi-directional transmission of WiMAXcompliant signaling over an 80-km PON, using a single optical wavelength. Colorless, bi-directional transmission of 256-QAM modulation on a 2.4-GHz RF carrier was achieved at 100- Mb/s (downlink) and 64-Mb/s (uplink)....

  6. Ageing and vascular ageing

    OpenAIRE

    2006-01-01

    There is an age related decline in various physiological processes. Vascular ageing is associated with changes in the mechanical and the structural properties of the vascular wall, which leads to the loss of arterial elasticity and reduced arterial compliance. Arterial compliance can be measured by different parameters like pulse wave velocity, augmentation index, and systemic arterial compliance. There is evidence that arterial compliance is reduced in disease states such as hypertension, di...

  7. Long term benzodiazepine use for insomnia in patients over the age of 60: discordance of patient and physician perceptions

    Directory of Open Access Journals (Sweden)

    Upshur Ross EG

    2002-05-01

    Full Text Available Abstract Background The aim of this study was to determine and compare patients' and physicians' perceptions of benefits and risks of long term benzodiazepine use for insomnia in the elderly. Methods A cross-sectional study (written survey was conducted in an academic primary care group practice in Toronto, Canada. The participants were 93 patients over 60 years of age using a benzodiazepine for insomnia and 25 physicians comprising sleep specialists, family physicians, and family medicine residents. The main outcome measure was perception of benefit and risk scores calculated from the mean of responses (on a Likert scale of 1 to 5 to various items on the survey. Results The mean perception of benefit score was significantly higher in patients than physicians (3.85 vs. 2.84, p Conclusions There is a significant discordance between older patients and their physicians regarding the perceptions of benefits and risks of using benzodiazepines for insomnia on a long term basis. The challenge is to openly discuss these perceptions in the context of the available evidence to make collaborative and informed decisions.

  8. Ageing and vascular ageing

    Science.gov (United States)

    Jani, B; Rajkumar, C

    2006-01-01

    There is an age related decline in various physiological processes. Vascular ageing is associated with changes in the mechanical and the structural properties of the vascular wall, which leads to the loss of arterial elasticity and reduced arterial compliance. Arterial compliance can be measured by different parameters like pulse wave velocity, augmentation index, and systemic arterial compliance. There is evidence that arterial compliance is reduced in disease states such as hypertension, diabetes, and end stage renal failure. Changes in arterial compliance can be present before the clinical manifestation of cardiovascular disease. Pharmacological and non‐pharmacological measures have been shown to improve arterial compliance. Arterial compliance may constitute an early cardiovascular risk marker and may be useful in assessing the effects of drugs on the cardiovascular system. Pharmacogenetics and genetics of arterial compliance in the future will improve our knowledge and understanding about vascular ageing. PMID:16754702

  9. Neighborhood physical disorder, social cohesion, and insomnia: results from participants over age 50 in the Health and Retirement Study.

    Science.gov (United States)

    Chen-Edinboro, Lenis P; Kaufmann, Christopher N; Augustinavicius, Jura L; Mojtabai, Ramin; Parisi, Jeanine M; Wennberg, Alexandra M V; Smith, Michael T; Spira, Adam P

    2014-09-15

    ABSTRACT Background: We determined the association between neighborhood socio-environmental factors and insomnia symptoms in a nationally representative sample of US adults aged >50 years. Methods: Data were analyzed from two waves (2006 and 2010) of the Health and Retirement Study using 7,231 community-dwelling participants (3,054 men and 4,177 women) in the United States. Primary predictors were neighborhood physical disorder (e.g. vandalism/graffiti, feeling safe alone after dark, and cleanliness) and social cohesion (e.g. friendliness of people, availability of help when needed, etc.); outcomes were insomnia symptoms (trouble falling asleep, night awakenings, waking too early, and feeling unrested). Results: After adjustment for age, income, race, education, sex, chronic diseases, body mass index, depressive symptoms, smoking, and alcohol consumption, each one-unit increase in neighborhood physical disorder was associated with a greater odds of trouble falling asleep (odds ratio (OR) = 1.09, 95% confidence interval (CI): 1.04-1.14), waking too early (OR = 1.05, 95% CI: 1.00-1.10), and, in adults aged ≥69 years (adjusting for all variables above except age), feeling unrested in the morning (OR = 1.11, 95% CI: 1.02-1.22 in 2006). Each one-unit increase in lower social cohesion was associated with a greater odds of trouble falling asleep (OR = 1.06, 95% CI: 1.01-1.11) and feeling unrested (OR = 1.09, 95% CI: 1.04-1.15). Conclusions: Neighborhood-level factors of physical disorder and social cohesion are associated with insomnia symptoms in middle-aged and older adults. Neighborhood-level factors may affect sleep, and consequently health, in our aging population.

  10. Immune responses induced by Hepa1-6 hepotoma cell after over-expression SEA and CD80 in vitro%SEA-CD80基因过表达Hepa1-6肝癌细胞体外诱导的免疫学效应

    Institute of Scientific and Technical Information of China (English)

    司少艳; 史亮; 刘俊丽; 宋淑军; 景青萍; 吴继华; 张建中

    2011-01-01

    This study is aimed to determine whether Hepal-6 hepotoma cells could induce antitumor immune response after over-expression Staphylococcus enterotoxin A (SEA) and CD80. Mouse spleen lymphocytes were cocultured with hepal-6 cells infected with empty adenoviruse vector Ad (empty) or the recombinant aden-oviruses of Ad-MMRE-mTERT-B7, Ad-MMRE-mTERT-SEA or Ad-MMRE-mTERT-BIS. Lymphocyte proliferation was assayed by BrdU incorporation using a commercial kit, flow cytometric analysis was used to detect proliferation of T Lymphocyte subgroups. The production of IL-2, TNF-a and IFN-γ was tested by enzyme-linked immunosorbent assay, and antitumor activity of CTL was determined by lactate dehydrogenase release assay. Compared with Hepa1-6 infected with empty adenovirus or without infection, Hepal-6 infected with recombinant adenoviruses could significantly induce proliferatioin of spleen lymphocytes and T Lymphocyte subgroups, enhance IL-2, TNF-a and IFN-γ production and CTL killing activities. The antitumor response was significantly stronger in Hepal-6 cells after dual-gene over-expression than that in Hepal-6 cells after single-gene over-expression. The results indicate that SEA and CD80 expressed on the membrane of Hepal-6 cells by infection with recombinant adenovirus has immune activities. This study provides some experimental evidence for further tumor immune genetherapy with the recombinant adenovirus.%观察经SEA和CD80重组腺病毒感染Hepa1-6肝癌细胞后体外能否诱导抗肿瘤免疫学反应.方法 Hepa1-6细胞分别经空载体腺病毒Ad(空)和重组腺病毒Ad-MMRE-mTERT-B7、Ad-MMRE-mTERT-SEA、Ad-MMRE -mTERT-BIS感染后,和小鼠脾淋巴细胞共培养,然后采用Brdu酶联免疫法(ELISA)检测淋巴细胞增殖;流式细胞术检测T淋巴细胞亚群增殖;ELISA法检测细胞因子IL-2、TNF-α和IFN-γ的产生;LDH释放法检测CTLs对Hepa1-6的杀伤作用.结果与感染空载体腺病毒Ad(空)和未感染Hepa 1-6细胞相比,

  11. No dramatic age-related loss of hair cells and spiral ganglion neurons in Bcl-2 over-expression mice or Bax null mice

    Directory of Open Access Journals (Sweden)

    Ohlemiller Kevin K

    2010-07-01

    Full Text Available Abstract Age-related decline of neuronal function is associated with age-related structural changes. In the central nervous system, age-related decline of cognitive performance is thought to be caused by synaptic loss instead of neuronal loss. However, in the cochlea, age-related loss of hair cells and spiral ganglion neurons (SGNs is consistently observed in a variety of species, including humans. Since age-related loss of these cells is a major contributing factor to presbycusis, it is important to study possible molecular mechanisms underlying this age-related cell death. Previous studies suggested that apoptotic pathways were involved in age-related loss of hair cells and SGNs. In the present study, we examined the role of Bcl-2 gene in age-related hearing loss. In one transgenic mouse line over-expressing human Bcl-2, there were no significant differences between transgenic mice and wild type littermate controls in their hearing thresholds during aging. Histological analysis of the hair cells and SGNs showed no significant conservation of these cells in transgenic animals compared to the wild type controls during aging. These data suggest that Bcl-2 overexpression has no significant effect on age-related loss of hair cells and SGNs. We also found no delay of age-related hearing loss in mice lacking Bax gene. These findings suggest that age-related hearing loss is not through an apoptotic pathway involving key members of Bcl-2 family.

  12. Potential drug-drug and drug-disease interactions in prescriptions for ambulatory patients over 50 years of age in family medicine clinics in Mexico City

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    Torres-Arreola Laura del Pilar

    2007-09-01

    Full Text Available Abstract Background In Mexico, inappropriate prescription of drugs with potential interactions causing serious risks to patient health has been little studied. Work in this area has focused mainly on hospitalized patients, with only specific drug combinations analyzed; moreover, the studies have not produced conclusive results. In the present study, we determined the frequency of potential drug-drug and drug-disease interactions in prescriptions for ambulatory patients over 50 years of age, who used Mexican Institute of Social Security (IMSS family medicine clinics. In addition, we aimed to identify the associated factors for these interactions. Methods We collected information on general patient characteristics, medical histories, and medication (complete data. The study included 624 ambulatory patients over 50 years of age, with non-malignant pain syndrome, who made ambulatory visits to two IMSS family medicine clinics in Mexico City. The patients received 7-day prescriptions for non-opioid analgesics. The potential interactions were identified by using the Thompson Micromedex program. Data were analyzed using descriptive, bivariate and multiple logistic regression analyses. Results The average number of prescribed drugs was 5.9 ± 2.5. About 80.0% of patients had prescriptions implying one or more potential drug-drug interactions and 3.8% of patients were prescribed drug combinations with interactions that should be avoided. Also, 64.0% of patients had prescriptions implying one or more potential drug disease interactions. The factors significantly associated with having one or more potential interactions included: taking 5 or more medicines (adjusted Odds Ratio (OR: 4.34, 95%CI: 2.76–6.83, patient age 60 years or older (adjusted OR: 1.66, 95% CI: 1.01–2.74 and suffering from cardiovascular diseases (adjusted OR: 7.26, 95% CI: 4.61–11.44. Conclusion The high frequency of prescription of drugs with potential drug interactions showed in

  13. An observational study of comorbidity and healthcare utilisation among HIV-positive patients aged 50 years and over.

    Science.gov (United States)

    Patel, Roshani; Moore, Thomas; Cooper, Vanessa; McArdle, Conor; Perry, Nicky; Cheek, Elizabeth; Gainsborough, Nicola; Fisher, Martin

    2016-07-01

    The number of HIV-positive people aged ≥50 years is rising each year. We measured the prevalence of non-infectious illnesses and their risk factors and described healthcare use in this UK population. A cross-sectional, observational study was conducted at an outpatient HIV specialist clinic in south east England. Patients age ≥50 years were invited to complete questionnaires measuring demographics, non-infectious illnesses, medication use, lifestyle and healthcare utilisation. The response rate was 67%. Of 299 participants, 84% reported ≥1 comorbid condition and 61% reported ≥2 (multimorbidity). Most commonly reported were high cholesterol, sexual dysfunction, hypertension and depression. In multivariate analyses, age, number of years HIV-positive and duration of antiretroviral therapy remained significant predictors of comorbidity when controlling for lifestyle factors (exercise, smoking and use of recreational drugs and alcohol). Use of non-HIV healthcare services was associated with increasing comorbidity, a longer duration of HIV and recreational drug use. The majority of HIV-patients aged ≥50 years reported multiple comorbidities and this was associated with polypharmacy and increased use of non-HIV services. Further research examining the quality, safety and patient experience of healthcare is needed to inform development of services to optimally meet the needs of older HIV-positive patients.

  14. Assessment of normal left atrial appendage anatomy and function over gender and ages by dynamic cardiac CT

    Energy Technology Data Exchange (ETDEWEB)

    Boucebci, Samy; Velasco, Stephane; Duboe, Pier-Olivier; Tasu, Jean-Pierre [University of Poitiers, University Hospital, Department of Radiology, Poitiers (France); Pambrun, Thomas [University of Poitiers, University Hospital, Department of Cardiology, Poitiers (France); Ingrand, Pierre [University of Poitiers, University Institute of Public Health, Poitiers (France)

    2016-05-15

    The aim of this study was to evaluate variations in anatomy and function according to age and gender using cardiac computed tomography (CT) in a large prospective cohort of healthy patients. The left atrial appendage (LAA) is considered the most frequent site of intracardiac thrombus formation. However, variations in normal in vivo anatomy and function according to age and gender remain largely unknown. Three-dimensional (3D) cardiac reconstructions of the LAA were performed from CT scans of 193 consecutive patients. Parameters measured included LAA number of lobes, anatomical position of the LAA tip, angulation measured between the proximal and distal portions, minimum (iVol{sub min}) and maximum (iVol{sub max}) volumes indexed to body surface area (BSA), and ejection fraction (LAAEF). Relationship with age was assessed for each parameter. We found that men had longer and wider LAAs. The iVol{sub min} and iVol{sub max} increased by 0.23 and 0.19 ml per decade, respectively, while LAAEF decreased by 2 % per decade in both sexes. Although LAA volumes increase, LAAEF decreases with age in both sexes. (orig.)

  15. Aging and memory for dreams.

    Science.gov (United States)

    Waterman, D

    1991-10-01

    This study investigated the influence of aging on memory for home drams and the extent to which cognitive variables such as visual memory, visuospatial IQ, and verbal IQ could account for possible differences herein. Subjects were 80 men and women of ages 45 to 75 years. Memory for dreams was measured by narrative length and frequency of recall. With respect to both measures no significant age differences were noted. Over-all differences in dream recall seemed best explained by visual memory scores. Partial correlational analyses, however, indicated that the small age differences memory or on any of the other cognitive variables. Dream contents were scored for aggression, friendliness, emotion, activities, and the number of characters and objects. The incidence of emotions among women appeared to be lower beyond the age of 60. Comparisons with previous data for young adults indicated that large reductions in aggression, friendliness, and emotion occur before the age of 45.

  16. Fat and carbohydrate intake over three generations modify growth, metabolism and cardiovascular phenotype in female mice in an age-related manner.

    Directory of Open Access Journals (Sweden)

    Samuel P Hoile

    Full Text Available Environmental challenges such as a high fat diet during pregnancy can induce changes in offspring growth, metabolism and cardiovascular function. However, challenges that are sustained over several generations can induce progressive compensatory metabolic adjustments in young adults. It is not known if such effects persist during ageing. We investigated whether diets with different fat and carbohydrate contents over three generations modifies markers of ageing. Female C57BL/6 F0 mice were fed diets containing 5% or 21% fat (w/w throughout pregnancy and lactation. Female offspring were fed the same diet as their dams until the F3 generation. In each generation, body weight, 24-hour food intake were recorded weekly, and plasma metabolites were measured by colorimetric assays, blood pressure by tail cuff plethysmography and vasoconstriction by myography on postnatal day 90 or 456. There was little effect of diet or generation on phenotypic markers in day 90 adults. There was a significant increase in whole body, liver and heart weight with ageing (d456 in the F3 21% fat group compared to the F1 and F3 5% groups. Fasting plasma glucose concentration was significantly increased with ageing in the 5% group in the F3 generation and in the 21% group in both generations. There was a significant effect of diet and generation on ex-vivo vasoconstriction in ageing females. Differences in dietary fat may induce metabolic compensation in young adults that persist over three generations. However, such compensatory effects decline during ageing.

  17. [Coronary artery disease in patient 80 years and older].

    Science.gov (United States)

    Hanon, Olivier

    2008-09-30

    The prevalence of coronary artery disease increases with age. Its clinical presentation is even less typical and its prognosis even more severe that it occurs in frail subjects with several co-morbidities. These atypical symptoms are often associated with a delayed diagnosis and therapy. The presence of comorbidities requires a comprehensive geriatric assessment to detect the existence of "frailty". Evidence based medicine available for coronary artery disease is based on studies that involve very few subjects over 80 years and recommendations are extrapolated from data based on evidence obtained in younger populations. Basically the strategy of treatments of coronary artery disease in octogenarians remains identical to the youngest subject. However, epidemiological studies indicate an under-prescription of recommended drugs whereas this older population is likely to derive the greatest benefit because of its elevated cardiovascular risk. Cautions for use of cardio-vascular therapies are necessary in octogenarian people because of comorbidities and pharmacokinetic and pharmacodynamic changes related to aging. Globally, the therapeutic strategy of coronary artery disease should be based not on the age but on an individual analysis that takes into account the severity of coronary artery disease, the existence of comorbidities, the iatrogenic risk, the expectancy and the quality of life of the patient.

  18. [Is the age of causality over?].

    Science.gov (United States)

    Antes, Gerd

    2016-01-01

    For the assessment of diagnostic and therapeutic interventions a sound scientific base has been developed during the last twenty years. Under the headline of Evidence-based Medicine nowadays a comprehensive set of tools is offered which can be used to assess the benefit and the risk of medical interventions. The overarching rule which evolved for the grading of evidence from studies is to maximize the protection against bias. Despite this coherent approach, there is still controversy that is regularly mainly sparked by the dominant position of randomized controlled trials. Observational studies and registries are deemed to be more relevant because they provide results that are produced under "everyday conditions". These controversial discussions often show a lack of orientation, as they do without the explicit naming of scientific criteria for the evaluation and to a large extent rely on common sense. That the latter may not be a good guide for assessments in the medical field is known from numerous studies. For unbiased assessments the rigorous use of basic scientific principles is the only way. To express doubt and question these principles requires a scientific basis itself. The alternative is to move away from the established scientific foundation. The path to a "new" scientific paradigm is currently dominated by a discussion under the buzzword Big Data. Defined by the three V's of Variety, Velocity and Volume, a potential of the unlimited analysis of data is envisioned, for which there is currently no validation and whose logical foundations are extremely doubtful. The demand must be reaffirmed that instead of promises strict validation criteria be followed for the evaluation of all interventions in medicine, particularly in view of these developments.

  19. Limitations in Activities of Daily Living in Community-Dwelling People Aged 75 and Over: A Systematic Literature Review of Risk and Protective Factors

    Science.gov (United States)

    Zijlstra, G. A. Rixt; Witte, Nico De; Duppen, Daan; Stuck, Andreas E.; Kempen, Gertrudis I. J. M.; Schols, Jos M. G. A.

    2016-01-01

    Background Most older people wish to age in place, for which functional status or being able to perform activities of daily living (ADLs) is an important precondition. However, along with the substantial growth of the (oldest) old, the number of people who develop limitations in ADLs or have functional decline dramatically increases in this part of the population. Therefore, it is important to gain insight into factors that can contribute to developing intervention strategies at older ages. As a first step, this systematic review was conducted to identify risk and protective factors as predictors for developing limitations in ADLs in community-dwelling people aged 75 and over. Methods Four electronic databases (CINAHL (EBSCO), EMBASE, PsycINFO and PubMed) were searched systematically for potentially relevant studies published between January 1998 and March 2016. Results After a careful selection process, 6,910 studies were identified and 25 were included. By far most factors were examined in one study only, and most were considered risk factors. Several factors do not seem to be able to predict the development of limitations in ADLs in people aged 75 years and over, and for some factors ambiguous associations were found. The following risk factors were found in at least two studies: higher age, female gender, diabetes, hypertension, and stroke. A high level of physical activity and being married were protective in multiple studies. Notwithstanding the fact that research in people aged 65 years and over is more extensive, risk and protective factors seem to differ between the ‘younger’ and ‘older’ olds. Conclusion Only a few risk and protective factors in community-dwelling people aged 75 years and over have been analysed in multiple studies. However, the identified factors could serve both detection and prevention purposes, and implications for future research are given as well. PMID:27760234

  20. Ventilation function changes in patients with Duchenne muscular dystrophy under and over 12 years of age Analysis of 65 cases

    Institute of Scientific and Technical Information of China (English)

    Zhiping Li; Yifeng Luo; Jianqiang Huang; Lihong Peng; Xiaoli Yao

    2008-01-01

    BACKGROUND: Previous studies indicate that vital capacity in patients with Duchenne muscular dystrophy increases with age when they are under 12 years old, and decreases from 13 or 14 years of age;however, recent studies indicate that the vital capacity in patients with Duchenne muscular dystrophy begins to decrease even before 12 years of age.OBJECTIVE: To verify if the vital capacity in patients with Duchenne muscular dystrophy decreases before the age of 12 years and to observe the effect of rehabilitation exercise on vital capacity.DESIGN, TIME AND SETTING: The case analysis was performed at the Department of Neurology,The First Affiliated Hospital of Sun Yat-Sen University (Guangzhou, Guangdong Province, China) from December 2004 to January 2006.PARTICIPANTS: Sixty-five male patients diagnosed as having Duchenne muscular dystrophy and who underwent pulmonary ventilation function examination at the Department of Neurology, The First Affiliated Hospital of Sun Yat-Sen University (Guangzhou, Guangdong Province, China) from December 2004 to January 2006; ages ranged from 6 to 22 years old.METHODS: The ventilation function of 65 patients was determined using a Sensor Medics 2100pulmonary function test apparatus (USA), and the data obtained were subjected to statistical analysis comparing patients under 12 years of age and those above 13 years of age, and comparing those who performed rehabilitation exercise with those who did not.MAIN OUTCOME MEASURES: Forced vital capacity (FVC); forced expiratory volume in one second (FEV1); maximal voluntary ventilation (MMV); the ratio of forced expiratory volume in one second and forced vital capacity (FEV1/FVC); each measured value as a percentage of the corresponding predicted value.RESULTS: There were no significant differences in FVC, FEV1 and MMV between patients under 12 years of age and those above 13 years of age (P > 0.05). The FVC, FEV1 and MMV values, as percentages of the predicted values, were, in patients under

  1. Alpha particles in solar cosmic rays over the last 80,000 years.

    Science.gov (United States)

    Lanzerotti, L. J.; Reedy, R. C.; Arnold, J. R.

    1973-01-01

    Present-day (1967 to 1969) fluxes of alpha particles from solar cosmic rays, determined from satellite measurements, were used to calculate the production rates of cobalt-57, cobalt-58, and nickel-59 in lunar surface samples. Comparisons with the activities of nickel-59 (half-life, 80,000 years) measured in lunar samples indicate that the long-term and present-day fluxes of solar alpha particles are comparable within a factor of approximately 4.

  2. Oral health of individuals aged 3-80 years in Jönköping, Sweden during 30 years (1973-2003). I. Review of findings on dental care habits and knowledge of oral health.

    Science.gov (United States)

    Hugoson, Anders; Koch, Göran; Göthberg, Catharina; Helkimo, Anna Nydell; Lundin, Sven-Ake; Norderyd, Ola; Sjödin, Bengt; Sondell, Katarina

    2005-01-01

    The aim of the present study was to compare data on dental care habits and knowledge of oral health in four cross-sectional epidemiological studies carried out in 1973,1983,1993, and 2003. The 1973 study constituted a random sample of 1,000 individuals evenly distributed in the age groups 3, 5, 10, 15, 20, 30, 40, 50, 60, and 70 years. The same age groups with addition of a group of 80-year-olds were included in the 1983, 1993 and 2003 studies, which comprised 1,104, 1,078, and 987 individuals, respectively. A questionnaire about dental care habits and knowledge of oral health was used in connection with a clinical and radiographic examination. The same questions were used in all the four studies. An addition to the 1993 and 2003 investigations were questions concerning ethnic background. In 2003 approximately 90-95 per cent of all individuals were visiting the dentist on a regular basis every or every second year. The 30- and 40-yea r-olds, however, did not visit a dentist as regularly in 2003 as in 1993. In these age groups 21-24 per cent of the individuals, respectively, reported that they had not visited a dentist in the last 2 years. Almost all children 3-15 years old received their dental care within the Public Dental Service (PDS). During the period 1973-2003 an increase in percentage of individuals aged 20-50 years treated by the PDS was seen compared to private practice, while among 60-80 year-olds there were only minor changes. Most so-year-olds and older received their dental care by private practitioners. About 70-80 per cent of all adults in 2003 were enrolled in a recall system on the dentist's initiative while in 1973 most appointments were based on the patient's own initiative. The number of individuals who were frightened, 5-17 per cent, or felt discomfort at the prospect of an appointment with the dentist was more or less the same during the whole period. The knowledge of the etiology of dental diseases did not changed much between 1973 and 2003

  3. What's Black and White and Re-Tweeted All Over? Teaching News Literacy in the Digital Age

    Science.gov (United States)

    Loth, Renee

    2012-01-01

    In 2007 the John S. and James L. Knight Foundation placed a major bet on State University of New York at Stony Brook: $1.7-million to enroll 10,000 students in its news-literacy curriculum over five years. Alberto Ibarguen, president and chief executive of the foundation, expected the course to foster "a group of students who would simply graduate…

  4. Influenza Vaccination Coverage Rate according to the Pulmonary Function of Korean Adults Aged 40 Years and Over: Analysis of the Fifth Korean National Health and Nutrition Examination Survey.

    Science.gov (United States)

    Cha, Seung-Hyun; Paik, Jeong-Hun; Lee, Mi-Ra; Yang, Huiho; Park, Seung-Guk; Jeon, Young-Jee; Yoo, Sunmi

    2016-05-01

    Influenza vaccination is an effective strategy to reduce morbidity and mortality, particularly for those who have decreased lung functions. This study was to identify the factors that affect vaccination coverage according to the results of pulmonary function tests depending on the age. In this cross-sectional study, data were obtained from 3,224 adults over the age of 40 who participated in the fifth National Health and Nutrition Examination Survey and underwent pulmonary function testing in 2012. To identify the factors that affect vaccination rate, logistic regression analysis was conducted after dividing the subjects into two groups based on the age of 65. Influenza vaccination coverage of the entire subjects was 45.2%, and 76.8% for those aged 65 and over. The group with abnormal pulmonary function had a higher vaccination rate than the normal group, but any pulmonary dysfunction or history of COPD did not affect the vaccination coverage in the multivariate analysis. The subjects who were 40-64 years-old had higher vaccination coverage when they were less educated or with restricted activity level, received health screenings, and had chronic diseases. Those aged 65 and over had significantly higher vaccination coverage only when they received regular health screenings. Any pulmonary dysfunction or having COPD showed no significant correlation with the vaccination coverage in the Korean adult population.

  5. Aging and Aged in Organized Crime.

    Science.gov (United States)

    Amir, Menachem

    1989-01-01

    Examines problems of the aged in organized crime, basing discussion on organized crime bosses over age 60 operating in Italy, the United States, and Israel. Looks at problems stemming from normative system in organized crime, role of the aged, intergenerational problems, fears of the aged, excuses and justifications, standards of life, and…

  6. Application of therapeutic ERCP in patients 80 years of age and older%高龄患者进行治疗性逆行胆管造影的经验体会

    Institute of Scientific and Technical Information of China (English)

    邵晓冬; 郭晓钟; 任丽楠; 赵佳均; 梁振东; 林浩

    2013-01-01

    Objective To evaluate the efficacy and the safety of therapeutic ERCP in patients 80 years of age and older with biliary and pancreatic diseases. Methods Patients with biliary and pancreatic diseases treated with therapeutic ERCP in our hospital from December 2005 to December 2011 were retrospectively reviewed. Results Two hundred and thirty seven patients underwent 268 therapeutic ERCP procedures. The indications included choledocholithiasis( 53. 2% ), malignant obstructive jaundice( 20. 2% ), biliary pancreatitis ( 10. 5% ),acute suppurative cholangitis( 9. 7% ),benign biliary stricture( 3. 4% )and others( 3. 0% ). The success rate of therapeutic ERCP was 94. 9% and 14. 6% of all procedures were emergent. Bile duct stones were completely cleared in 95. 4% of patients with cho-ledocholithiasis. Four patients underwent ERBD and two patients were referred for surgical intervention due to unsuccessful clearance of bile duct stone. Metal biliary stents were inserted in 23 patients with malignant obstructive jaundice. Plastic biliary stents were inserted in 34 patients,of which 11 patients underwent stent replacement because of stent occlustion. Unsuccessful ERCP procedures occurred in 12 cases. There were 183( 77. 2% )patients with peripapillary diverticulum. Complications occurred in 6 patients including cholangitis( 2 cases ), pancreatitis( 1 case ), hemorrhage( 2 cases )and perforation( 1 case )and there was no death case in the group. Conclusion For patients 80 years of age and older with biliary and pancreatic diseases, therapeutic ERCP is an effective and safe treatment.%目的 评估在80岁以上高龄患者中经逆行胆管造影(ERCP)进行胆胰疾病治疗的疗效和安全性.方法 回顾性分析该院自2005年12月-2011年12月经ERCP进行胆胰疾病治疗的80岁以上高龄患者的病历资料.结果 237例80岁以上高龄患者共进行了268例次治疗性ERCP.患者行ERCP治疗的原因有:胆管结石(53.2%)、恶性梗阻性黄疸(20.2%)

  7. The controversy over the association between statins use and progression of age-related macular degeneration: a mini review

    Directory of Open Access Journals (Sweden)

    Vasileios Peponis

    2010-07-01

    Full Text Available Vasileios Peponis1, Spyridon E Chalkiadakis1, Stefanos Bonovas2,3, Nikolaos M Sitaras21Athens Eye Hospital, 2nd Eye Clinic, Athens, Greece; 2Department of Pharmacology, School of Medicine, University of Athens, Greece; 3Center for Diseases Control and Prevention, Athens, GreeceObjective: Age-related macular degeneration (AMD is the leading cause of blindness in ¬western societies. Statins comprise a class of pharmacological agents that reduce plasma cholesterol levels, and have been shown to prevent progression of atherosclerosis and reduce cardiovascular mortality. The relationship between these medications and AMD has been evaluated in several recent studies. Herein, we examine the current evidence for an association between statin use and risk of AMD.Methods: Literature database search (Medline, Scopus, and Science Citation Index Expanded for articles published up to March 2010, using particular search terms.Results: From the current evidence available, it is not safe to conclude upon the assumption of a protective effect of statins against age-related maculopathy and AMD.Conclusion: There is a need for large scale prospective studies with a long follow-up period and accurate assessment of AMD to further explore this matter.Keywords: age-related macular degeneration (AMD, blindness, statin use, controversy

  8. Evaluation of Concordance between Hip and Spine T Scores in the Diagnosis of Osteoporosis in Men Over Age of Fifty

    Directory of Open Access Journals (Sweden)

    Oya Özdemir

    2015-12-01

    Full Text Available Objective: The aim of this study was to evaluate the concordance in diagnosis of osteoporosis based on the World Health Organization (WHO classification of bone mineral density (BMD measurements of hip and spine in men aged ≥50 years. Materials and Methods: The BMD measurements, which were measured via dual x-ray energy absorptiometry (DXA, of 10.049 patients admitted to our hospital between January 1, 2012 and August 1, 2013 were retrospectively reviewed and 649 men aged ≥50 years were included in the study. It was defined as minor discordance when the difference between two sites was no more than one WHO diagnostic class. Major discordance was present when one site is osteoporotic and the other is normal. Results: The mean age of the participants was 68.7±9.1 (50-93 years. The mean values of lumbar spine and total hip BMD values were 1.1681±0.231 (0.629-2.267 g/cm2 and 0.933±0.152 (0.414-1.444 g/cm2, respectively. According to L1-L4 vertebra T score, 54.4% of the individuals were classified as normal, 33% were osteopenic, and 12.6% were osteoporotic. Whereas, according to total femur T score 41.7% of participants were normal, 47.5% had osteopenia, and 10.8% had osteoporosis. Concordance of T scores, minor discordance, and major discordance were seen in 59.6%, 37.6%, and 2.8% of the patients, respectively. Conclusion: In this study, it was shown that in 4 of every 10 male patients aged ≥50 years tested by DXA, T score discordance between spine and total hip measurement sites is present. This ratio is similar to the results of previous studies investigating the prevalence of this phenomenon in larger samples including both postmenopausal women and men. Clinicians should keep in their mind that T score discordance is a prevalent finding and can be related to various physiological and pathological patient factors as well as the performance or analysis of DXA itself.

  9. Corrosion of Artificial Aged Magnesium Alloy AZ80 in 3.5 wt pct NaCl Solutions

    Institute of Scientific and Technical Information of China (English)

    Rongchang ZENG; Enhou HAN; Wei KE

    2007-01-01

    The corrosion morphologies of aged magnesium alloy AZ80 were investigated by immersion corrosion tests,scanning electron microscopy (SEM), electrochemical measurement. The T5 heat treatment was carried out in a vacuum furnace, holding for 16 h at 177℃, and then cooling in air. The results showed intergranular corrosion (IGC) occurred as an aged AZ80 sample was immersed in 3.5 wt pct NaCl aqueous solution for 1 h and the narrow path attack progressed predominantly along the bulk β phase in the grain boundaries or took place in the eutectic areas. IGC was attributed to the network distribution of β phase along the grain boundaries, the depleted aluminium in the precipitation areas and the breakdown potential.

  10. Prevalence of Cognitive Impairment and Depression among a Population Aged over 60 Years in the Metropolitan Area of Guadalajara, Mexico.

    Science.gov (United States)

    Ortiz, Genaro G; Arias-Merino, Elva D; Flores-Saiffe, María E; Velázquez-Brizuela, Irma E; Macías-Islas, Miguel A; Pacheco-Moisés, Fermín P

    2012-01-01

    Background. Cognitive impairment is an important clinical issue among elderly patients with depression and has a more complex etiology because of the variable rate of neurodegenerative changes associated with depression. The aim of the present work was to examine the prevalence of cognitive impairment and depression in a representative sample of adults aged ≥60 years. Methods. The presented work was a cross-sectional study on the prevalence of cognitive impairment and depression. Door-to-door interview technique was assigned in condition with multistage probability random sampling to obtain subjects that represent a population of the Guadalajara metropolitan area (GMA), Mexico. Cognitive function and depression were assessed by applying standardized Mini-Mental State Examination of Folstein (MMSE) and the Geriatric Depression Scale (GDS), respectively. Results. Prevalence of cognitive impairment was 13.8% (14.5% women, 12.6% men); no significant differences by gender and retired or pensioner were found. Prevalence of depression was 29.1% (33.6% women, 21.1% men); no significant differences by retired or pensioner were found. Cognitive impairment was associated with depression (OR  =  3.26, CI 95%, 2.31-4.60). Prevalence of cognitive impairment and depression is associated with: being woman, only in depression being older than 75 years being married, and a low level of education. Conclusion. Cognitive impairment and depression are highly correlated in adults aged ≥60.

  11. Prevalence of Cognitive Impairment and Depression among a Population Aged over 60 Years in the Metropolitan Area of Guadalajara, Mexico

    Directory of Open Access Journals (Sweden)

    Genaro G. Ortiz

    2012-01-01

    Full Text Available Background. Cognitive impairment is an important clinical issue among elderly patients with depression and has a more complex etiology because of the variable rate of neurodegenerative changes associated with depression. The aim of the present work was to examine the prevalence of cognitive impairment and depression in a representative sample of adults aged ≥60 years. Methods. The presented work was a cross-sectional study on the prevalence of cognitive impairment and depression. Door-to-door interview technique was assigned in condition with multistage probability random sampling to obtain subjects that represent a population of the Guadalajara metropolitan area (GMA, Mexico. Cognitive function and depression were assessed by applying standardized Mini-Mental State Examination of Folstein (MMSE and the Geriatric Depression Scale (GDS, respectively. Results. Prevalence of cognitive impairment was 13.8% (14.5% women, 12.6% men; no significant differences by gender and retired or pensioner were found. Prevalence of depression was 29.1% (33.6% women, 21.1% men; no significant differences by retired or pensioner were found. Cognitive impairment was associated with depression (OR  =  3.26, CI 95%, 2.31–4.60. Prevalence of cognitive impairment and depression is associated with: being woman, only in depression being older than 75 years being married, and a low level of education. Conclusion. Cognitive impairment and depression are highly correlated in adults aged ≥60.

  12. Visual disability and major causes of blindness in NSW: a study of people aged 50 and over attending the Royal Blind Society 1984 to 1989.

    Science.gov (United States)

    Chan, C W; Billson, F A

    1991-11-01

    Visual disability in individuals aged 50 years and over seeking services of the Royal Blind Society in the years 1984 to 1989, was studied with respect to changes in frequency of major causes together with age and sex of those affected. The results mirror statistics in the UK. Age-related macular degeneration (AMD) accounts for an increasing proportion of visual disability (34% in 1984 to 43% in 1989). Of particular interest was the frequency of disability attributed to cataract. While decreasing (24% in 1984 to 19% in 1989), cataract still represents a significant cause of potentially treatable disability. The authors conclude that there is a changing prevalence of visual disability caused mainly by an increase in AMD and a subgroup of patients attending for services who appear to have a potentially remediable disability. These conclusions affirm the need for close liaison between ophthalmological practitioners and agencies for the blind.

  13. Chronic conditions and sleep problems among adults aged 50 years or over in nine countries: a multi-country study.

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    Ai Koyanagi

    Full Text Available Data on the association between chronic conditions or the number of chronic conditions and sleep problems in low- or middle-income countries is scarce, and global comparisons of these associations with high-income countries have not been conducted.Data on 42116 individuals 50 years and older from nationally-representative samples of the Collaborative Research on Ageing in Europe (Finland, Poland, Spain and the World Health Organization's Study on Global Ageing and Adult Health (China, Ghana, India, Mexico, Russia, South Africa conducted between 2011-2012 and 2007-2010 respectively were analyzed.The association between nine chronic conditions (angina, arthritis, asthma, chronic lung disease, depression, diabetes, hypertension, obesity, and stroke and self-reported severe/extreme sleep problems in the past 30 days was estimated by logistic regression with multiple variables. The age-adjusted prevalence of sleep problems ranged from 2.8% (China to 17.0% (Poland. After adjustment for confounders, angina (OR 1.75-2.78, arthritis (OR 1.39-2.46, and depression (OR 1.75-5.12 were significantly associated with sleep problems in the majority or all of the countries. Sleep problems were also significantly associated with: asthma in Finland, Spain, and India; chronic lung disease in Poland, Spain, Ghana, and South Africa; diabetes in India; and stroke in China, Ghana, and India. A linear dose-dependent relationship between the number of chronic conditions and sleep problems was observed in all countries. Compared to no chronic conditions, the OR (95%CI for 1,2,3, and ≥ 4 chronic conditions was 1.41 (1.09-1.82, 2.55 (1.99-3.27, 3.22 (2.52-4.11, and 7.62 (5.88-9.87 respectively in the overall sample.Identifying co-existing sleep problems among patients with chronic conditions and treating them simultaneously may lead to better treatment outcome. Clinicians should be aware of the high risk for sleep problems among patients with multimorbidity. Future studies

  14. Smoking and Alzheimer's disease among Mongolian and Han Chinese aged 55 years and over living in the Inner Mongolia farming area of China

    Institute of Scientific and Technical Information of China (English)

    Chunyu Zhang; Lin Da; Shigang Zhao; Desheng Wang; Guangming Niu; Huriletemuer

    2012-01-01

    Residents aged 55 years or older from 27 communities and two settlements in Xilingol League of Inner Mongolia were selected for participation in an Alzheimer's disease epidemiological investigation from June 2008 to June 2009, including 3 259 Mongolians and 5 887 Han Chinese.The Mongolian subjects in the Alzheimer's disease group were at age of 55 years or older (on average), and more of them were male, illiterate and/or had a history of coronary artery disease and/or diabetes compared with the Mongolian subjects in the non-Alzheimer's disease group. The Han Chinese subjects in the Alzheimer's disease group were at age of 55 years or older (on average) and more of them were women, illiterate and/or had a history of coronary artery disease,and less of them had a history of alcohol consumption compared with the non-Alzheimer's disease group. Non-conditional multivariate stepwise logistic regression identified that male gender,increasing age and having a history of diabetes and/or coronary heart disease were associated with higher odds of Alzheimer's disease among Mongolians while having an educational background was associated with lower odds (OR = 0.259, 95%CI 0.174-0.386). Among the Han Chinese subjects, male gender, increasing age and having a history of coronary heart disease and/or hypertension was associated with higher odds of Alzheimer's disease, while having an educational background was associated lower odds (OR = 0.271, 95%CI 0.192-0.381). The results also indicated that extremely heavy smoking may be a risk factor for Alzheimer's disease in Mongolian males aged over 55 years. There was no significant difference in smoking habits between the Mongolian and Han Chinese subjects with Alzheimer's disease.

  15. Neck pain, concerns of falling and physical performance in community-dwelling Danish citizens over 75 years of age

    DEFF Research Database (Denmark)

    Kendall, Julie C; Boyle, Eleanor; Hartvigsen, Jan

    2017-01-01

    AIMS: The aim of this study was to determine the associations between neck pain, concerns of falling and physical performance in older people. METHODS: Cross-sectional study of 423 community-dwelling Danes aged 75 years and older. Measures consisted of self-reported neck pain, physical performance...... between neck pain and fear of falling were determined using multivariable logistic regression modelling. RESULTS: Bothersome neck pain that limits daily activities is significantly associated with concerns of falling (unadjusted odds ratio (OR) 3.29, 95% confidence interval (CI) 1.54-7.03) and impaired...... physical performance (unadjusted OR 2.26, 95% CI 1.09-4.69). However, these relationships became nonsignificant after adjusting for potential confounders. Bothersome neck pain and concerns of falling is attenuated by depression, and the relationship between bothersome neck pain and decreased physical...

  16. Polyphenol Intake from Beverages in Japan over an 18-Year Period (1996-2013): Trends by Year, Age, Gender and Season.

    Science.gov (United States)

    Taguchi, Chie; Fukushima, Yoichi; Kishimoto, Yoshimi; Saita, Emi; Suzuki-Sugihara, Norie; Yoshida, Daishi; Kondo, Kazuo

    2015-01-01

    An association between the dietary intake of polyphenols and human health has been shown in many epidemiological studies. Since beverages are rich sources of polyphenols, we aimed to evaluate the polyphenol intake from beverages in Japanese individuals with a focus on differences according to year, age, gender and season. More than 10,000 Japanese male and female subjects aged 1-99 y old participated in this survey every year from 1996 to 2013, and their beverage consumption and amount of polyphenol intake were calculated. Polyphenol intake from beverages in Japan showed no tendency to increase or decrease over the 18-y period, and the major sources of polyphenols in Japanese daily life were coffee and green tea. Polyphenol intake was larger in participants with higher age up to 59 y old in both male and female subjects. There was a slight difference in polyphenol intake by gender, with adult males consuming more polyphenols than adult females. Polyphenols were consumed slightly more in the winter than the summer, although the seasonal difference in polyphenol intake was not large. Our results suggest that polyphenol intake from beverages is influenced by age rather than gender or season in Japan, and may not have changed over time, at least over the 18-y period beginning in 1996 in Japan.

  17. Memory and Aging

    Science.gov (United States)

    Memory and Aging Losing keys, misplacing a wallet, or forgetting someone’s name are common experiences. But for people nearing or over age 65, such memory lapses can be frightening. They wonder if they ...

  18. Prevalence of hypertension among individuals aged 50 years and over and its impact on health related quality of life in a semi-rural area of western Turkey

    Institute of Scientific and Technical Information of China (English)

    Didem Arslantas; Unal Ayranci; Alaettin Unsal; Mustafa Tozun

    2008-01-01

    Background Hypertension is common,especially in individuals aged 40 years and over,and it affects about half of the population aged 60 years and over.This study aimed to determine the frequency and risk factors of hypertension among individuals aged 50 years and over,and to examine its effect on the health related quality of life(HRQOL).Methods This population-based cross-sectional study was conducted in two settlements in a region of western Turkey between March 1 and April 30,2007.A questionnaire concerning life habits associated with hypertension,medical histories,and demographic characteristics was filled in by a face to face interview.The SF·36 scale was used to assess HRQOL Body mass index(BMI)was calculated by measuring the weight and length of the body. Results of 1599 individuals living in the region,1193 participated in the survey(48.3%men and 51.7%women).The overall prevalence rate of hypertension was 59.5%(n=710),being 58.O%in men and 60.9% in women(P>0.05).The variables that most positively influenced hypertension(P≤0.05,for each one)were older age(especially the age group of those aged 60 and over),single,no health insurance,consumption of animal fat in meals,and family history of hypertension.The HRQOL of the patients with hypertension was lower than that of those without hypertension(P≤0.05). The HRQOL was better in hypertensive patients whose blood pressure was under control,whereas it was worse in those with at least one chronic disorder accompanying hypertension(P≤0.05,for each one).Conclusions Great emphasis should be placed on the need for a public health program for the detection,prevention, and control of hypertension,including other risk factors,as well as for the modification of foods and life habits,specifically in individuals who are most likely to be at risk of hypertension.

  19. Optical imagery and spectrophotometry of CTB 80

    Science.gov (United States)

    Hester, J. Jeff; Kulkarni, Shrinivas R.

    1989-01-01

    Narrow-band imagery and spectrophotometry of the central region of CTB 80 are presented. The images show weak forbidden O III and ubiquitous filamentary forbidden S II and H-alpha emission from the extended radio lobes in which the core is embedded. The data indicate that the extended component is shock heated. Balmer line-dominated emission is observed around the perimeter of the core. Assuming that the volume of the radio shell is similar to the volume of the thermal shell, it is found that a magnetic field of about 600 microG and a cosmic-ray proton-to-electron ratio of about 200 are required to explain the pressure and synchrotron volume emissivity in the radio shell. It is suggested that the optical emission form the core of CTB 80 arises behind shocks which are being driven into a magnetized thermal plasma by the confined relativistic wind from PSR 1951+32.

  20. Carotid artery surgery in patients over 70 years of age.

    Science.gov (United States)

    Benhamou, A C; Kieffer, E; Tricot, J F; Maraval, M; Lethoai, H; Benhamou, M; Boespflug, O; Natali, J

    1981-01-01

    Between 1965 and 1979, 934 patients underwent 1,057 operations for extracranial carotid stenosis at this institute, and over a recent 30-month period 463 patients underwent 511 operations of this type. This number is equal to the total of operations performed during the years 1965-1976. The increase in the frequency of carotid artery surgery has been more marked in patients of over 70 years. The percentage of elderly patients has increased from 17.5% to 27% in the recent period. In the latter group of 511 operations, results were good in 93.17% of cases, while there was a mortality rate of 1.95% (1% of which were directly related to the surgery), in 1.95% the neurologic condition deteriorated and in 3.13% there was no change. In the first period the mortality rate for patients over 70 years of age was 7.69%. In the second it was 3.27% (1.63% of which were due to non-neurologic causes), 4.09% deteriorated, in 2.18% there was no change and good results were obtained in 90.46%.

  1. Coronary bypass surgery in patients aged 70 years and over: Mortality, morbidity, & length of stay. Dar al-fouad experience

    Directory of Open Access Journals (Sweden)

    Ahmed Ghali

    2014-03-01

    This study supports the continued performance of coronary artery bypass grafting in patients 70 years. Advanced age alone should not deter a cardiac surgeon from offering such a potentially beneficial intervention.

  2. Social gradients in self-reported health and well-being among adults aged 50 and over in Pune District, India

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    Siddhivinayak Hirve

    2010-09-01

    Full Text Available Background: India’s older population is projected to increase up to 96 million by 2011 with older people accounting for 18% of its population by 2051. The Study on Global Ageing and Adult Health aims to improve empirical understanding of health and well-being of older adults in developing countries. Objectives: To examine age and socio-economic changes on a range of key domains in self-reported health and well-being amongst older adults. Design: A cross-sectional survey of 5,430 adults aged 50 and over using a shortened version of the SAGE questionnaire to assess self-reported assessments (scales of 1–5 of performance, function, disability, quality of life and well-being. Self-reported responses were calibrated using anchoring vignettes in eight key domains of mobility, self-care, pain, cognition, interpersonal relationships, sleep/energy, affect, and vision. WHO Disability Assessment Schedule Index and WHO health scores were calculated to examine for associations with socio-demographic variables. Results: Disability in all domains increased with increasing age and decreasing levels of education. Females and the oldest old without a living spouse reported poorer health status and greater disability across all domains. Performance and functionality self-reports were similar across all SES quintiles. Self-reports on quality of life were not significantly influenced by socio-demographic variables. Discussion: The study provides standardised and comparable self-rated health data using anchoring vignettes in an older population. Though expectations of good health, function and performance decrease with age, self-reports of disability severity significantly increased with age, more so if female, if uneducated and living without a spouse. However, the presence or absence of spouse did not significantly alter quality of life self-reports, suggesting a possible protective effect provided by traditional joint family structures in India, where older

  3. Age-related prefrontal over-recruitment in semantic memory retrieval: Evidence from successful face naming and the tip-of-the-tongue state.

    Science.gov (United States)

    Galdo-Alvarez, Santiago; Lindín, Mónica; Díaz, Fernando

    2009-09-01

    Studies that have attempted to determine the effects of aging on the brain neural sources of memory retrieval have reported two contrasting age effects: under-recruitment and over-recruitment of several prefrontal areas. However, the causes for these effects are still a matter of debate. In order to study the underlying factors that cause the effects, we compared brain activation in young and older adults, in a successful word retrieval condition, and a failed word retrieval condition: the tip-of-the-tongue state. For this, we used the event-related potentials technique and neural source estimation with low-resolution tomographies. The results showed that the older adults did not display under-recruitment in any brain area in comparison with the young adults. However, they displayed additional prefrontal activation that varied depending on the processing stage and the condition, which supports the hypothesis of selective over-recruitment in older adults.

  4. Self reported health status, and health service contact, of illicit drug users aged 50 and over: a qualitative interview study in Merseyside, United Kingdom

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    Duffy Paul

    2009-10-01

    Full Text Available Abstract Background The populations of industrialised countries are ageing; as this occurs, those who continue to use alcohol and illicit drugs age also. While alcohol use among older people is well documented, use of illicit drugs continues to be perceived as behaviour of young people and is a neglected area of research. This is the first published qualitative research on the experiences of older drug users in the United Kingdom. Methods Semi-structured interviews were conducted in Merseyside, in 2008, with drug users aged 50 and over recruited through drug treatment services. Interviews were recorded and transcribed and analysed thematically. Only health status and health service contact are reported here. Results Nine men and one woman were interviewed (age range: 54 to 61 years; all but one had been using drugs continuously or intermittently for at least 30 years. Interviewees exhibited high levels of physical and mental morbidity; hepatitis C was particularly prevalent. Injecting-related damage to arm veins resulted in interviewees switching to riskier injecting practices. Poor mental health was evident and interviewees described their lives as depressing. The death of drug-using friends was a common theme and social isolation was apparent. Interviewees also described a deterioration of memory. Generic healthcare was not always perceived as optimal, while issues relating to drug specific services were similar to those arising among younger cohorts of drug users, for example, complaints about inadequate doses of prescribed medication. Conclusion The concurrent effects of drug use and ageing are not well understood but are thought to exacerbate, or accelerate the onset of, medical conditions which are more prevalent in older age. Here, interviewees had poor physical and mental health but low expectations of health services. Older drug users who are not in contact with services are likely to have greater unmet needs. The number of drug users

  5. Partial-thickness articular surface rotator cuff tears in patients over the age of 35: Etiology and intra-articular associations

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    Chetan S Modi

    2012-01-01

    Full Text Available Purpose: Partial-thickness articular-sided rotator cuff tears have a multifactorial etiology and are associated with degeneration of the tendon. They are often described as an injury of the young athlete, although they are also found in the older population. The aim of this study was to investigate the frequency and associations of partial-thickness articular-sided tears in patients over the age of 35 years. Design: Retrospective Materials and Methods: A retrospective study of all arthroscopic procedures for rotator cuff pathology in patients over the age of 35 years over a 2-year period by a single surgeon was performed. The included patients were divided into two groups based on the arthroscopic findings: those with a partial-thickness articular-sided rotator cuff tear and those with pure tendinopathy. The groups were then compared to identify the associated pathology with the rotator cuff lesions. 2×2 contingency table analysis and unpaired Student′s t-test were used for statistical analysis. Results: One hundred patients were included in the study of whom 62 had a partial articular-sided tear. Those with a partial articular-sided tear were older (P=0.0001, were more commonly associated with a documented injury (P=0.03, and more commonly had biceps degeneration (P=0.001 and synovitis (P=0.02 within the joint. Conclusion: Partial-thickness articular-sided tears are a common occurrence in patients requiring arthroscopic surgery for rotator cuff pathology over the age of 35 years. This probably reflects an injury in an already degenerate cuff. This would support the theory of intrinsic degeneration of the tendon in this age group and probably represent a different etiology to those seen in the young athletes. Level of Evidence: Level 3

  6. Generation, transmission and wavelength conversion an 80 Gbit/s RZ-DBPSK-ASK signal

    DEFF Research Database (Denmark)

    Tokle, Torger; Andersen, Peter Andreas; Geng, Yan

    2005-01-01

    An 80 Gbit/s RZ-DBPSK-ASK signal is generated using orthogonal phase and amplitude modulation. We demonstrate its transmission over an 80 km SMF+DCF fibre span, and wavelength conversion using FWM in a highly nonlinear PCF......An 80 Gbit/s RZ-DBPSK-ASK signal is generated using orthogonal phase and amplitude modulation. We demonstrate its transmission over an 80 km SMF+DCF fibre span, and wavelength conversion using FWM in a highly nonlinear PCF...

  7. Effectiveness of daily living abilities (DLA) as a tool for evaluating vocational competencies: study of non-disabled workers aged 45 and over.

    Science.gov (United States)

    Kikuchi, E; Murakami, K

    1995-05-01

    A questionnaire survey was conducted on 28-55 items of daily living abilities (DLA) linked to 13 basic vocational competencies such as memory, learning, planning, judgement, muscular power and concentration covering a total of 505 non-disabled blue collar male workers aged 45 and over. Results of the survey were as follows, (1) The 457 subjects were grouped into five groups ranging from normal to unsound groups according to the degree of DLA; (2) The reduction of DLA has directionality to two factors, memory and muscular power; (3) DLA provide clues for aging; (4) Among basic vocational competencies, muscular power showed the highest performance with a small standard deviation, while concentration scored low points with a large standard deviation (p learning ability, agility and concentration (p < .05); Since the findings showed various characteristics of vocational competencies and the aging process precisely in blue collar workers aged 45 and over, we assumed that the DLA survey is one of the alternatives for evaluating workers vocational competencies.

  8. Baroreflex Sensitivity in Relation to Clinical Characteristics in Subject Aged 40 to 80 Years

    DEFF Research Database (Denmark)

    Brinth, Louise Schouborg; Pors, Kirsten; Latif, Tabassam;

    2014-01-01

    in our population comprising one component reflecting the sympathetic activity, the parasympathetic system, and the integrated spontaneous BRS, respectively. The parasympathetic component was the only one correlating with clinical characteristics of declining age, smoking habits, systolic blood pressure...... on the Framingham score. BRS was found to decline with age, but this change disappeared when correcting for the age related increase in systolic blood pressure. We found that the VM-derived indices of sympathetic vascular control declined with age as did the vagally controlled heart rate changes in response to deep...... breathing and VM. We could not demonstrate any correlation between BRS, smoking status, and body size when adjusting for age and gender, whereas spontaneous BRS was reduced with increasing Framingham risk score. Principal component analysis revealed three component explaining 69% of the total variance...

  9. Cognitive Control Deficits in Shifting and Inhibition in Preschool Age Children are Associated with Increased Depression and Anxiety Over 7.5 Years of Development.

    Science.gov (United States)

    Kertz, Sarah J; Belden, Andy C; Tillman, Rebecca; Luby, Joan

    2016-08-01

    Although depression and anxiety are common in youth (Costello et al. 2003), factors that put children at risk for such symptoms are not well understood. The current study examined associations between early childhood cognitive control deficits and depression and anxiety over the course of development through school age. Participants were 188 children (at baseline M = 5.42 years, SD = 0.79 years) and their primary caregiver. Caregivers completed ratings of children's executive functioning at preschool age and measures of depression and anxiety severity over seven assessment waves (a period of approximately 7.5 years). Longitudinal multilevel linear models were used to examine the effect of attention shifting and inhibition deficits on depression and anxiety. Inhibition deficits at preschool were associated with significantly greater depression severity scores at each subsequent assessment wave (up until 7.5 years later). Inhibition deficits were associated with greater anxiety severity from 3.5 to 7.5 years later. Greater shifting deficits at preschool age were associated with greater depression severity up to 5.5 years later. Shifting deficits were also associated with significantly greater anxiety severity up to 3.5 years later. Importantly, these effects were significant even after accounting for the influence of other key predictors including assessment wave/time, gender, parental education, IQ, and symptom severity at preschool age, suggesting that effects are robust. Overall, findings indicate that cognitive control deficits are an early vulnerability factor for developing affective symptoms. Timely assessment and intervention may be beneficial as an early prevention strategy.

  10. SNC 80 and related delta opioid agonists.

    Science.gov (United States)

    Calderon, S N; Coop, A

    2004-01-01

    The discovery of the selective delta (delta) opioid agonists SNC 80 and BW373U86, which possess a diarylmethylpiperazine structure unique among opioids, was a major advance in the field of delta-opioid ligands. Much research has been performed to uncover the structure-activity relationships (SAR) of this class of ligands and also to compare the diarylmethylpiperazines with the traditional morphinan-based delta opioids. This review focuses on the development of the SAR of this unique series of ligands, and discusses questions which remain unanswered.

  11. Effect of multivitamin and multimineral supplementation on cognitive function in men and women aged 65 years and over: a randomised controlled trial

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    Ramsay Craig R

    2007-05-01

    Full Text Available Abstract Background Observational studies have frequently reported an association between cognitive function and nutrition in later life but randomised trials of B vitamins and antioxidant supplements have mostly found no beneficial effect. We examined the effect of daily supplementation with 11 vitamins and 5 minerals on cognitive function in older adults to assess the possibility that this could help to prevent cognitive decline. Methods The study was carried out as part of a randomised double blind placebo controlled trial of micronutrient supplementation based in six primary care health centres in North East Scotland. 910 men and women aged 65 years and over living in the community were recruited and randomised: 456 to active treatment and 454 to placebo. The active treatment consisted of a single tablet containing eleven vitamins and five minerals in amounts ranging from 50–210 % of the UK Reference Nutrient Intake or matching placebo tablet taken daily for 12 months. Digit span forward and verbal fluency tests, which assess immediate memory and executive functioning respectively, were conducted at the start and end of the intervention period. Risk of micronutrient deficiency at baseline was assessed by a simple risk questionnaire. Results For digit span forward there was no evidence of an effect of supplements in all participants or in sub-groups defined by age or risk of deficiency. For verbal fluency there was no evidence of a beneficial effect in the whole study population but there was weak evidence for a beneficial effect of supplementation in the two pre-specified subgroups: in those aged 75 years and over (n 290; mean difference between supplemented and placebo groups 2.8 (95% CI -0.6, 6.2 units and in those at increased risk of micronutrient deficiency assessed by the risk questionnaire (n 260; mean difference between supplemented and placebo groups 2.5 (95% CI -1.0, 6.1 units. Conclusion The results provide no evidence for a

  12. The Activity of Influenza and Influenza-like Viruses in Individuals Aged over 14 in the 2015/2016 Influenza Season in Poland.

    Science.gov (United States)

    Kowalczyk, D; Cieślak, K; Szymański, K; Brydak, L B

    2017-02-15

    Infections in every epidemic season induced by respiratory viruses, especially by the influenza virus, are the cause of many illnesses and complications which often end in death. The aim of this study was to determine the activity of influenza and influenza-like viruses in individuals aged over of 14 in Poland during the 2015/2016 epidemic season. A total of 5070 specimens taken from patients were analyzed. The presence of the influenza virus was confirmed in 40.2% of cases, among which the subtype A/H1N1/pdm09 (62.6% positive samples) predominated. The analysis of confirmed influenza and influenza-like viruses in individuals divided into four age-groups demonstrate that the highest morbidity was reported for the age ranges: 45-64 (13.1%) and 26-44 (12.6%) years. An increase in the number of influenza type B cases (23.7% positive samples), which was the main cause of morbidity in the age group 15-25 years, was noticeable. Given the epidemiological and virological data, the 2015/2016 season in Poland was characterized by increased activity of the influenza virus compared to the previous season. In the 2015/2016 season, there were more than 3.8 million cases and suspected cases of influenza and influenza-like illness, more than 15,000 hospitalizations, and up to 140 deaths.

  13. Prevalence and risk factors for vitamin C deficiency in north and south India: a two centre population based study in people aged 60 years and over.

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    Ravilla D Ravindran

    Full Text Available BACKGROUND: Studies from the UK and North America have reported vitamin C deficiency in around 1 in 5 men and 1 in 9 women in low income groups. There are few data on vitamin C deficiency in resource poor countries. OBJECTIVES: To investigate the prevalence of vitamin C deficiency in India. DESIGN: We carried out a population-based cross-sectional survey in two areas of north and south India. Randomly sampled clusters were enumerated to identify people aged 60 and over. Participants (75% response rate were interviewed for tobacco, alcohol, cooking fuel use, 24 hour diet recall and underwent anthropometry and blood collection. Vitamin C was measured using an enzyme-based assay in plasma stabilized with metaphosphoric acid. We categorised vitamin C status as deficient (28 µmol/L. We investigated factors associated with vitamin C deficiency using multivariable Poisson regression. RESULTS: The age, sex and season standardized prevalence of vitamin C deficiency was 73.9% (95% confidence Interval, CI 70.4,77.5 in 2668 people in north India and 45.7% (95% CI 42.5,48.9 in 2970 from south India. Only 10.8% in the north and 25.9% in the south met the criteria for adequate levels. Vitamin C deficiency varied by season, and was more prevalent in men, with increasing age, users of tobacco and biomass fuels, in those with anthropometric indicators of poor nutrition and with lower intakes of dietary vitamin C. CONCLUSIONS: In poor communities, such as in our study, consideration needs to be given to measures to improve the consumption of vitamin C rich foods and to discourage the use of tobacco.

  14. [Quality of the diet of the Spanish population over 80 years non-institutionalized].

    Science.gov (United States)

    Hernández Galiot, Ana; Goñi Cambrodón, Isabel

    2015-06-01

    Introducción: los adultos mayores no institucionalizados son un colectivo que suele presentar alto riesgo de malnutrición. Detectar problemas nutricionales mediante indicadores de la calidad global de la dieta, es un reto para los profesionales de la salud, de utilidad para la planificación de políticas nutricionales. Objetivo: determinar la calidad global de la dieta de la población española mayor de 80 años no institucionalizada, para promover y fomentar la calidad de vida del anciano. Metodología: se seleccionaron las personas mayores de 80 años del Estudio Longitudinal Envejecer en España 2011-2013 (n = 159), residentes en diversas zonas españolas. Para valorar la calidad de la dieta se utilizó el índice de alimentación saludable (IAS), la frecuencia de consumo de alimentos y el grado de adhesión al patrón de dieta Mediterránea (ADM). Resultados: la población presentó valores de IAS cercanos a los correspondientes a una dieta saludable. Un porcentaje significativo necesitaba cambios en su alimentación, siendo los mayores de 90 años los que requirieron una mayor intervención dietética. La mayoría de la población cumplió las recomendaciones de la dieta mediterránea, aunque se observó bajo consumo de verduras, hortalizas, frutos secos y vino; y elevado consumo de embutidos. Conclusiones: la dieta consumida habitualmente por los españoles mayores de 80 años no institucionalizados presenta desajustes nutricionales que podrían corregirse realizando pequeños cambios en su patrón dietético. Determinar la calidad global de la dieta permite la planificación de estrategias de intervención para promover cambios alimentarios saludables y emprender acciones orientadas al mantenimiento de una salud óptima en el binomio envejecimiento-nutrición.

  15. Association of Risk Perception and Information Provided on the Labels of Over-the-Counter Drugs: Role of Race, Education, Age and Income

    Directory of Open Access Journals (Sweden)

    Sunil Mathur

    2014-01-01

    Full Text Available Background: The use of over-the-counter (OTC drugs has increased tremendously, however, information on risk perception regarding the use of OTC drugs and their potential toxicity is scarce. Hence, the purpose of this study was to investigate the perception of OTC drug safety and efficacy based on reading product packaging and the effect of race, education, age and income. Methods: We used the HINTS 2012 data set with total sample size of 2,554. Results: OTC drug users having some high school education had a lower chance of frequently reading information included in the product labeling with the OTC medication. OTC drug users less than 50 years of age were always likely to read drug information on the OTC drug labeling. Also, Non-Hispanic blacks were more likely to read OTC drug labeling than Non-Hispanic whites.  OTC drug users less than 50 years of age consider OTC drugs safer than prescription drugs.  Conversely, OTC drug users with a high school, some college or bachelor’s degree consider OTC drugs less safe than prescription drugs.  Non-Hispanic blacks, non-Hispanic whites, and subjects of lower income were less likely to consider OTC drugs safer than prescription drugs.  OTC drug users with a high school education and some college perceive OTC drugs to be less effective than prescription drugs.Conclusion: To conclude, age, education, race, and income affect risk perception on OTC drugs.  Consumer information programs need to be designed so that meaningful results can be incorporated into public policy. Providing information on the labeling of OTC drugs and likelihood of patients reading this information require further study.

  16. 9 CFR 71.18 - Individual identification of certain cattle 2 years of age or over for movement in interstate...

    Science.gov (United States)

    2010-01-01

    ... cattle 2 years of age or over for movement in interstate commerce. 71.18 Section 71.18 Animals and Animal... certain cattle 2 years of age or over for movement in interstate commerce. (a) No cattle 2 years of age or over, except steers and spayed heifers and cattle of any age which are being moved interstate...

  17. How Do African American Young Adult Females (AAYAF) over 16 Years of Age Make Career Decisions?

    Science.gov (United States)

    Grayson, Nancy Mathea

    2010-01-01

    Scope and Method of Study: The overall purpose of the study was to describe the perceptions regarding how AAYAF over 16 years of age plan and make career decisions. The study participants included ten AAYAF over 16 years of age. The young women were interviewed fact-to-face using a semi-structured open-ended questionnaire. The questionnaire was…

  18. Stein and Leventhal: 80 years on.

    Science.gov (United States)

    Azziz, Ricardo; Adashi, Eli Y

    2016-02-01

    Eighty years ago a publication in the Journal proved to be seminal and transformative. The report by Irving Freiler Stein and Michael Leventhal titled, "Amenorrhea associated with polycystic ovaries," has proven to be a remarkably lasting and influential publication. The growth in related literature has been increasing exponentially: the 50 years between 1950 and 2000 saw a little more than 8000 publications on the topic, whereas the 15 year period between 2001 and 2015 (so far) has seen more than 20,000 related publications, a greater than 8-fold increase in the publication rate after 2000. As we commemorate the 80th anniversary year of the publication of the report by Stein and Leventhal, it is important to ask ourselves, "Was this publication truly as seminal as it is generally assumed to be? And why did it gain such a strong foothold on the medical psyche?" To the first question, a review of the antecedent medical literature makes it clear that the report of Drs Stein and Leventhal in 1935, although not flawless, was both seminal and transformative. In fact, it was the first report to describe a series of patients, rather than isolated cases, who demonstrated the triad of polycystic ovaries, hirsutism, and oligo/amenorrhea, connecting what had previously been disparate features of polycystic ovaries and menorrhagia, and hirsutism and oligo/amenorrhea. Second, the facts that Dr Stein and his collaborators were relatively prolific writers, consistent and clear in their message and descriptions; that a possible therapy (bilateral ovarian wedge resection) had been conveniently included in the report; and that the disorder was (is) relatively prevalent, permitted what would eventually be called the Stein-Leventhal syndrome to gain a strong foothold in contemporary medical practice. Overall, we in the field of medicine have much to celebrate, as we commemorate the 80th anniversary of the publication of the report by Stein and Leventhal in 1935, for a new disorder was

  19. Social class differences in secular trends in established coronary risk factors over 20 years: a cohort study of British men from 1978-80 to 1998-2000.

    Directory of Open Access Journals (Sweden)

    Sheena E Ramsay

    Full Text Available BACKGROUND: Coronary heart disease (CHD mortality in the UK since the late 1970s has declined more markedly among higher socioeconomic groups. However, little is known about changes in coronary risk factors in different socioeconomic groups. This study examined whether changes in established coronary risk factors in Britain over 20 years between 1978-80 and 1998-2000 differed between socioeconomic groups. METHODS AND FINDINGS: A socioeconomically representative cohort of 7735 British men aged 40-59 years was followed-up from 1978-80 to 1998-2000; data on blood pressure (BP, cholesterol, body mass index (BMI and cigarette smoking were collected at both points in 4252 survivors. Social class was based on longest-held occupation in middle-age. Compared with men in non-manual occupations, men in manual occupations experienced a greater increase in BMI (mean difference = 0.33 kg/m(2; 95%CI 0.14-0.53; p for interaction = 0.001, a smaller decline in non-HDL cholesterol (difference in mean change = 0.18 mmol/l; 95%CI 0.11-0.25, p for interaction≤0.0001 and a smaller increase in HDL cholesterol (difference in mean change = 0.04 mmol/l; 95%CI 0.02-0.06, p for interaction≤0.0001. However, mean systolic BP declined more in manual than non-manual groups (difference in mean change = 3.6; 95%CI 2.1-5.1, p for interaction≤0.0001. The odds of being a current smoker in 1978-80 and 1998-2000 did not differ between non-manual and manual social classes (p for interaction = 0.51. CONCLUSION: Several key risk factors for CHD and type 2 diabetes showed less favourable changes in men in manual occupations. Continuing priority is needed to improve adverse cardiovascular risk profiles in socially disadvantaged groups in the UK.

  20. Case Study Regarding the Interests and Leisure Practices of Persons Aged 50 and over in Saint-Léonard, Suburb of Montreal: Seniors Vs. Baby Boomers

    Directory of Open Access Journals (Sweden)

    Roult Romain

    2016-06-01

    Full Text Available Introduction. Several studies have shown that leisure contributes to improving seniors’ quality of life. However, some of this research has also highlighted the fact that there are marked physical, socioeconomic, and cultural disparities in this population. Material and methods. To this end, this article presents the results of a survey conducted in 2015 in Montreal with 464 respondents aged 50 and over regarding their interests and leisure practices. Results. This study highlights the importance that persons in this age group give to physical and outdoor recreation as well as free and outdoor activities. However, this study has also confirmed that there exist, regarding the problem of leisure, more or less significant differences among seniors and baby boomers which need to be taken into account by local actors. Conclusions. The results obtained and the correlated analyses clearly indicate that the senior population is not homogeneous with respect to their practices and their leisure needs. This analytical finding confirms that leisure and community services must be planned, programmed, and promoted taking into account these generational differences, as well as physical, socioeconomic, and cultural differences.

  1. Management of OAB in those over age 65.

    Science.gov (United States)

    Natalin, Ricardo; Lorenzetti, Fabio; Dambros, Miriam

    2013-10-01

    The International Continence Society (ICS) defines overactive bladder (OAB) as an association of symptoms including "urgency, with or without urge incontinence, usually with increased frequency and nocturia". This conditon has been associated with a decrease in quality of life and a higher related risk of overall health condition decrease, and is rising since its prevalence increases with age and the forecast for the world population estimates an increase of those over 65 years old. Aging alone can be considered a major risk factor for developing OAB symptoms that are considered multifactorial and due to body tissue and anatomic changes, lifestyle-associated factors, comorbidities and personal characteristics. The high prevalence of this condition and multiple etiology factors makes of its treatment a challenge-especially in the older population. A major concern over OAB treatment of elderly patients is the risk of cognitive side effects due to the pharmacologic treatment with anticholinergic drugs. First-line treatment for OAB symptoms are the use of pharmacologic therapy with antimuscarinic drugs, which has been proved to be effective in controlling urgency, urge incontinence episodes, incontinence episodes, and nocturia. The impact caused by this condition is significant regarding the economic and human costs associated bringing into attention the need of studying and reviewing this specific population. Conservative Management and Lifestyle Modifications: Behavioral therapy's aims are to reduce urinary frequency and urgency to an accepted level and to increase bladder outlet volume. It consists of actions to teach patients to improve and learn bladder control. Lifestyle modifications are a conjunct of daily activities that can be managed to have the lowest interference on the functioning of the urinary tract. Pharmacologic Therapy: There are various medications with antimuscarinic properties available for the treatment of OAB symptoms. The most commonly used are

  2. Hearing in old age - epidemiological and etiological aspects

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Introduction The number of elderly persons is increasing all over the world. This strong demographic trend will affect our societies profoundly. Since the largest relative increase is expected to occur in the group of very old persons, over 80 years of age, the demands on the society and on relatives in terms of health- and social care are considerable.

  3. National observatory on the therapeutic management in ambulatory care patients aged 65 and over, with type 2 diabetes, chronic pain or atrial fibrillation.

    Science.gov (United States)

    Becquemont, Laurent; Benattar-Zibi, Linda; Bertin, Philippe; Berrut, Gilles; Corruble, Emmanuelle; Danchin, Nicolas; Delespierre, Tiba; Derumeaux, Geneviève; Falissard, Bruno; Forette, Francoise; Hanon, Olivier; Pasquier, Florence; Pinget, Michel; Ourabah, Rissane; Piedvache, Céline

    2013-01-01

    The primary objective of the S.AGES cohort is to describe the real-life therapeutic care of elderly patients. Patients and methods. This is a prospective observational cohort study of 3 700 non-institutionalized patients over the age of 65 years with either type 2 diabetes mellitus (T2DM), chronic pain or atrial fibrillation (AF) recruited by French general practitioners (GPs). Follow-up is planned for 3 years. Baseline characteristics. In the chronic pain sub-cohort, 33% of patients are treated with only grade 1 analgesics, 29% with grade 2 analgesics and 3% with grade 3 analgesics, and 22% have no pain treatment. In the T2DM sub-cohort, 61% of patients have well-controlled diabetes (Hb1c<7%) and 18% are treated with insulin. In the AF sub-cohort, 65% of patients have a CHADS2 score greater than 2, 77% are treated with oral anticoagulants, 17% with platelet inhibitors, 40% with antiarrhythmic drugs and 56% with rate slowing medications. Conclusion. The S.AGES cohort presents a unique opportunity to clarify the real-life therapeutic management of ambulatory elderly subjects and will help to identify the factors associated with the occurrence of major clinical events.

  4. Subjective Age in Early Adolescence: Relationships with Chronological Age, Pubertal Timing, Desired Age, and Problem Behaviors

    Science.gov (United States)

    Hubley, Anita M.; Arim, Rubab G.

    2012-01-01

    Subjective age generally refers to the age that one feels. In a cross-sectional questionnaire study of 245 adolescents ages 10-14 years, we examined (a) whether, and when, a cross-over in subjective age occurs, (b) differences in subjective age among pubertal timing groups, (c) correlations between subjective age and each of desired age and five…

  5. Oxygenated compounds in aged biomass burning plumes over the Eastern Mediterranean: evidence for strong secondary production of methanol and acetone

    Directory of Open Access Journals (Sweden)

    R. Holzinger

    2004-10-01

    Full Text Available Airborne measurements of acetone, methanol, PAN, acetonitrile (by Proton Transfer Reaction Mass Spectrometry, and CO (by Tunable Diode Laser Absorption Spectroscopy have been performed during the Mediterranean Intensive Oxidants Study (MINOS, August 2001. In the course of the campaign 10 biomass burning plumes, identified by strongly elevated acetonitrile mixing ratios, were found. The characteristic biomass burning signatures obtained from these plumes reveal secondary production of acetone and methanol, while CO photochemically declines in the plumes. Mean excess mixing ratios – normalized to CO – of 1.8%, 0.20%, 3.8%, and 0.65% for acetone, acetonitrile, methanol, and PAN, respectively, were found in the plumes. By scaling to an assumed global annual source of 663–807 Tg CO, biomass burning emissions of 25–31 and 29–35 Tg/yr for acetone and methanol are estimated, respectively. Our measurements suggest that the present biomass burning contributions of acetone and methanol are significantly underestimated due to the neglect of secondary formation. Median acetonitrile mixing ratios throughout the troposphere were around 150 pmol/mol; this is in accord with current biomass burning inventories and an atmospheric lifetime of ~6 months.

  6. Encapsulated Ketoprofen by Chitosan-Alginat based on Type and Variation of Tween 80 and Span 80 Concentration.

    OpenAIRE

    Tuti Wukirsari; Mersi Kurniati; Napthaleni; Purwantiningsih Sugita

    2010-01-01

    Encapsulated Ketoprofen by Chitosan-Alginat based on Type and Variation of Tween 80 and Span 80Concentration. Ketoprofen has been encapsulated by chitosan-alginate based on types of surfactant and it’sconcentration. The variations of concentration either Tween 80 (polietilena sorbitanmonooleat) or Span 80(sorbitanmonooleat) that used were around (1- 3)% concentrations with stirring around (15-60) minutes. The using ofTween 80 resulted efficiency of encapsulated ketoprofen and nano particle si...

  7. The prevalence of hypertension, obesity and dyslipidemia in individuals of over 30 years of age belonging to minorities from the pasture area of Xinjiang

    Directory of Open Access Journals (Sweden)

    Luo Wen-Li

    2010-02-01

    Full Text Available Abstract Background The prevalence of population-wide hypertension, obesity and dyslipidemia has not been well studied in the pasture area of Xinjiang. The present epidemiological study was performed to determine the prevalence of hypertension, obesity and dyslipidemia in minority populations from the pasture area of Xinjiang and to discuss the potential risk factors for hypertension. Methods A population-based, cross-sectional study in the Xinjiang pasture area was performed which included 2251 participants aged over 30 years (90.33% participation rate of whom 71.26% were Kazaks. Several risk factors were considered: hypertension (defined as systolic or diastolic blood pressure or both of at least 140/90 mmHg measured on one occasion or treatment for hypertension overweight/obesity (body mass index ≥ 25 kg/m2 alcohol intake, smoking/tobacco use and dyslipidemia. Outcomes were prevalence of hypertension, obesity and dyslipidemia and the associated risk factors of hypertension detected by multivariate logistic regression analysis taking into account various metabolic and lifestyle characteristics. Results The prevalence of hypertension, overweight/obesity and dyslipidemia in all participants from the pasture area of Xinjiang was 51.9%, 47.9% and 49.2% respectively. Independently, the prevalence and awareness of hypertension was 52.6% and 15.3% among Kazaks (n = 1604, 54.6% and 14.1% among Uygurs (n = 418, 39.5% and 16.1% among Mongolians (n = 81 and 43.9% and 18.2% among non-Xinjiang-born Han immigrants (n = 148. The prevalence of overweight/obesity in Kazaks, Uygurs, Mongolians and Han immigrants was 46.7%, 48.9%, 62.5% and 50.3%, respectively. The prevalence of dyslipidemia in the four ethnic groups mentioned was 53.5%, 34.8%, 49.3% and 47.3%, respectively. The mean blood pressure in all participants was 136/86 mmHg (pre-hypertensive, the mean BMI was 24.7 kg/m2. Based on multiple logistic regression analysis, the significant risk factors for

  8. Screening for distress, the 6th vital sign: common problems in cancer outpatients over one year in usual care: associations with marital status, sex, and age

    Directory of Open Access Journals (Sweden)

    Giese-Davis Janine

    2012-10-01

    Full Text Available Abstract Background Very few studies examine the longitudinal prevalence of problems and the awareness or use of clinical programs by patients who report these problems. Of the studies that examine age, gender and marital status as predictors of a range of patient outcomes, none examines the interactions between these demographic variables. This study examined the typical trajectory of common practical and psychosocial problems endorsed over 12 months in a usual-care sample of cancer outpatients. Specifically, we examined whether marital status, sex, age, and their interactions predicted these trajectories. We did not actively triage or refer patients in this study in order to examine the natural course of problem reports. Methods Patients completed baseline screening (N = 1196 of 1707 approached and the sample included more men (N = 696 than women (N = 498, average age 61.1 years. The most common diagnoses were gastrointestinal (27.1%, prostate (19.2%, skin (11.1% and gynecological (9.2%. Among other measures, patients completed a Common Problem Checklist and Psychosocial Resources Use questions at baseline, 3, 6, and 12 months using paper and pencil surveys. Results Results indicated that patients reported psychosocial problems more often than practical and both decreased significantly over time. Younger single patients reported more practical problems than those in committed relationships. Younger patients and women of all ages reported more psychosocial problems. Among a number of interesting interactions, for practical problems, single older patients improved more; whereas among married people, younger patients improved more. For psychosocial problems we found that older female patients improved more than younger females, but among males, it was younger patients who improved more. Young single men and women reported the most past-and future-use of services. Conclusions Younger women are particularly vulnerable to experiencing

  9. [Stroke and aging].

    Science.gov (United States)

    Ly, J; Maquet, P

    2014-01-01

    Stroke risk increases with aging and one third of ischemic strokes occurs in very elderly (> or = 80 years). These are responsible of two thirds of the overall stroke-related morbi-mortality. Stroke in very elderly differs from younger individuals by sex ratio (more women), risk factors (more atrial fibrillation and hypertension) and usually a worse functional outcome. Very elderly are likely to benefit from stroke unit care and early revascularisation treatments although they have historically been excluded from this urgent management. These issues are likely to worsen in the future with the increasing impact of stroke on our aging societies.

  10. A cross-sectional survey of the relationship between walking, biking, and the built environment for adults aged over 70 years

    Directory of Open Access Journals (Sweden)

    Takahashi PY

    2012-04-01

    Full Text Available Paul Y Takahashi1, Mitzi A Baker3, Stephan Cha2, Paul V Targonski11Primary Care Internal Medicine, 2Biomedical Statistics and Informatics, Mayo Clinic, 3Planning Department, Olmsted County, Rochester, MN, USAPurpose: Determine the relationship between walkability scores (using the Walk Score® and activity levels (both bicycle and walking in adults aged between 70 and 85 years in Rochester, Minnesota.Patients and methods: This was a self-reported cross-sectional survey in adults aged over 70 years living in Rochester, Minnesota. Analysis used t-tests or chi-square analysis as appropriate. The primary endpoint was bicycle use or walking. The predictor variables were the Walk Score® as determined by their address, Charlson index, Duke Activity Status Index (DASI, and a 12-item short-form survey (SF-12 scores. Secondary analysis used an outcome of functional status (using the DASI and walkability scores.Results: Fifty-three individuals completed the surveys (48% return rate. The average age in the overall cohort was 77.02 years. Eighty-nine percent of individuals could walk at least a block and 15.1% rode their bicycles. The Walk Scores® did not differ between those who walked (38.9 ± 27.4 and those that did not (40.0 ± 36.08; P = 0.93. In a similar fashion, the Walk Scores® were not different for those who biked (36.38 ± 27.68 and those that did not (39.44 ± 28.49; P = 0.78. There was no relationship between Walk Scores® and DASI; however, a decreased DASI score was associated with increased age and comorbid illness (Charlson Score.Conclusion: In this small pilot survey, there was no difference in Walk Scores® between those older adults who walked or biked, compared to those that did not. The Walk Scores® were low in both groups, which may indicate the lack of accessibility for all older adults living in Rochester, Minnesota. The functional status seemed to be more related to age or comorbid conditions than the built environment

  11. Structure and forces in bentonite MX-80

    Energy Technology Data Exchange (ETDEWEB)

    Joensson, Bo; Aakesson, Torbjoern; Joensson, Bengt; Meehdi, Segad; Janiak, John; Wallenberg, Reine (Theoretical Chemistry, Chemical Center, Lund Univ., Lund (Sweden))

    2009-03-15

    Wyoming bentonite (MX-80) and its ion exchanged forms, Na and Ca montmorillonite, have been studied experimentally and theoretically. A variety of experimental techniques have been used in order to gain insight into the structural conditions in dry clay as well as clay in equilibrium with a bulk solution of given ionic composition. The main objective has been the swelling behaviour and osmotic pressure of montmorillonite clay when the bulk solution contains a mix of monovalent sodium and divalent calcium ions. For a clay system in equilibrium with pure water, Monte Carlo simulations predict a large swelling when the clay counterions are monovalent, while in presence of divalent counterions a limited swelling is predicted with an aqueous layer between the clay lamellaes of about 1 nm. This latter result is in excellent agreement with small angle x-ray scattering data, but in disagreement with dialysis experiments, which gives a significantly larger swelling for Ca montmorillonite in pure water. Obviously, there is one lamellar swelling and a second 'extra-lamellar' swelling, which could be the result of a phase separation in the clay. Montmorillonite in contact with a salt reservoir with both Na+ and Ca2+ counterions will only show a modest swelling unless the sodium concentration in the bulk is several orders of magnitude larger than the calcium concentration. The limited swelling of clay in presence of divalent counterions is a consequence of ion-ion correlations, which reduce the entropic repulsion as well as give rise to an attractive component in the total osmotic pressure. Ion-ion correlations also favour divalent counterions in a situation where we have a competition with monovalent ones. A more fundamental result of ion-ion correlations is that the osmotic pressure as a function of clay sheet separation becomes nonmonotonic, which indicates the possibility of a phase separation into a concentrated and a dilute clay phase. This phenomenon could

  12. The clinical analysis of patients aged80 years with hospital infection of mycotic pneumonia%80岁及以上老年患者医院感染真菌性肺炎的临床分析

    Institute of Scientific and Technical Information of China (English)

    周春; 吴玉泉; 张金彭; 郑赟; 卢小军

    2012-01-01

    目的 观察年龄≥80岁患者医院感染真菌性肺炎的临床特点并进行综合分析. 方法 2007年6月至2011年7月住院的64例医院感染真菌性肺炎老年患者,年龄80~93岁,平均85.6岁.收集临床资料,根据痰培养结果制订治疗方案,选择敏感的抗细菌药物.同时进行疗效判定. 结果 64例医院感染真菌性肺炎患者痰培养中以白色假丝酵母菌占首位(62.5%,40例),其次为光滑假丝酵母菌(20.3%,13例),二者比较差异有统计学意义(x2=127.50,P<0.01);胸部X线或CT片缺乏特异性,但片状阴影(68.8%,44例)和团絮状阴影(40.6%,26例)占多数;60例(93.8%)患者同时合并3种以上的疾病;58例(90.6%)曾应用2种以上抗生素;治愈率81.3% (52例),病死率18.8%(12例). 结论 年龄80岁及以上患者医院感染真菌性肺炎发生率增高,病死率高,治愈的关键是及早确诊、及早治疗.%Objective To analyze the clinical characteristics of hospital acquired mycotic pneumonia in elderly patients (aged≥ 80 years).Methods The clinical data were reviewed on 64 cases of elderly patients aged 80-93 years with hospital-acquired infection of mycotic pneumonia from June 2007 to July 2011.According to the results of sputum culture,therapy plan was made and antibiotic drugs were selected.Results Among these 64 patients,Candida mycoderma (62.5 %,40 cases) occupied the first place and C.glabrata (20.3%,13 cases) was the second place (x2 =127.50,P<0.01).Their chest x-ray or CT films were not characteristic,but lamellar shadows (68.8%,44cases) and cotton-like shadows (40.6 %,26 cases) were found in the majority.60 cases (93.8 % ) of these patients had more than 3 complications,and 58 cases (90.6%) of them took over 2 kinds of antibiotics.The improvement rate of these patients was 81.3% (52 cases)and mortality rate was 18.8%(12 cases).Conclusions Elderly patients (aged≥ 80 years) with hospital acquired infection of mycotic

  13. Psychological Treatment of Depression in People Aged 65 Years and Over: A Systematic Review of Efficacy, Safety, and Cost-Effectiveness

    Science.gov (United States)

    Jonsson, Ulf; Bertilsson, Göran; Gyllensvärd, Harald; Söderlund, Anne; Tham, Anne; Andersson, Gerhard

    2016-01-01

    Objectives Depression in elderly people is a major public health concern. As response to antidepressants is often unsatisfactory in this age group, there is a need for evidence-based non-pharmacological treatment options. Our objectives were twofold: firstly, to synthesize published trials evaluating efficacy, safety and cost-effectiveness of psychological treatment of depression in the elderly and secondly, to assess the quality of evidence. Method The electronic databases PubMed, EMBASE, Cochrane Library, CINAL, Scopus, and PsycINFO were searched up to 23 May 2016 for randomized controlled trials (RCTs) of psychological treatment for depressive disorders or depressive symptoms in people aged 65 years and over. Two reviewers independently assessed relevant studies for risk of bias. Where appropriate, the results were synthesized in meta-analyses. The quality of the evidence was graded according to GRADE (Grading of Recommendations Assessment, Development and Evaluation). Results Twenty-two relevant RCTs were identified, eight of which were excluded from the synthesis due to a high risk of bias. Of the remaining trials, six evaluated problem-solving therapy (PST), five evaluated other forms of cognitive behavioural therapy (CBT), and three evaluated life review/reminiscence therapy. In frail elderly with depressive symptoms, the evidence supported the efficacy of PST, with large but heterogeneous effect sizes compared with treatment as usual. The results for life-review/reminiscence therapy and CBT were also promising, but because of the limited number of trials the quality of evidence was rated as very low. Safety data were not reported in any included trial. The only identified cost-effectiveness study estimated an incremental cost per additional point reduction in Beck Depression Inventory II score for CBT compared with talking control and treatment as usual. Conclusion Psychological treatment is a feasible option for frail elderly with depressive symptoms

  14. 21 CFR 226.80 - Packaging and labeling.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Packaging and labeling. 226.80 Section 226.80 Food...: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR TYPE A MEDICATED ARTICLES Packaging and Labeling § 226.80 Packaging and labeling. (a) Packaging and labeling operations shall be adequately controlled: (1) To...

  15. Ageing and skills

    DEFF Research Database (Denmark)

    Desjardins, Richard; Warnke, Arne Jonas

    of countries. Specifically, repeated measures will enable an analysis of whether there is skill gain and skill loss over the lifespan of cohorts and overtime between cohorts. This is especially important because age-skill profiles observed on the basis of a single cross-section are difficult to interpret...... the lifespan and over time....

  16. Encapsulated Ketoprofen by Chitosan-Alginat based on Type and Variation of Tween 80 and Span 80 Concentration.

    Directory of Open Access Journals (Sweden)

    Tuti Wukirsari

    2010-11-01

    Full Text Available Encapsulated Ketoprofen by Chitosan-Alginat based on Type and Variation of Tween 80 and Span 80Concentration. Ketoprofen has been encapsulated by chitosan-alginate based on types of surfactant and it’sconcentration. The variations of concentration either Tween 80 (polietilena sorbitanmonooleat or Span 80(sorbitanmonooleat that used were around (1- 3% concentrations with stirring around (15-60 minutes. The using ofTween 80 resulted efficiency of encapsulated ketoprofen and nano particle size (100-1000 nm are higher than Span 80.

  17. 7 CFR 984.80 - Books and other records.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Books and other records. 984.80 Section 984.80... Regulating Handling Reports, Books, and Other Records § 984.80 Books and other records. Each handler shall... for the purpose of performing its functions under this subpart. Such books and records shall...

  18. 18 CFR 367.80 - Supervision and engineering.

    Science.gov (United States)

    2010-04-01

    ... engineering. 367.80 Section 367.80 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... ACT Operating Expense Instructions § 367.80 Supervision and engineering. (a) The supervision and engineering includible in the operating expense accounts must consist of the pay and expenses...

  19. Changes in Oxidative Stress and Inflammatory Biomarkers in Fragile Adults over Fifty Years of Age and in Elderly People Exclusively Fed Enteral Nutrition

    Directory of Open Access Journals (Sweden)

    Maria D. Mesa

    2016-01-01

    Full Text Available We aim to evaluate whether exclusive feeding of an enteral formula enriched with n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA affects oxidative stress and the antioxidant defence system and may improve the levels of some relevant inflammatory, and cardiovascular biomarkers in frail adults over fifty years of age and in elderly subjects. Fifty-five patients were divided into two groups and were exclusively fed a newly designed normoproteic and isocaloric enteral formula enriched with eicosapentaenoic (98 mg/d and docosahexaenoic acids (46 mg/d (n=26 or a reference enteral diet (n=29. Oxidative, inflammatory and cardiovascular risk biomarkers and red blood cell fatty acid profiles were determined at the beginning and after 90 and 180 days of feeding. The n-3 LC-PUFA percentage tended to be higher (P=0.053 in the experimental group than in the reference group. Administration of the n-3 LC-PUFA diet did not increase oxidative stress or modify plasma antioxidant capacity but decreased antioxidant enzymatic activities. MMP-9 plasma concentration decreased with both formulae, whereas tPAI-1 tended to decrease (P=0.116 with the administration of the experimental formula. In conclusion, administration of the new n-3 LC-PUFA-enriched product for 6 months did not negatively alter the oxidative status and improved some cardiovascular risk biomarkers.

  20. The Sciences and Aging. Adding to the Knowledge about Aging.

    Science.gov (United States)

    Mason, W. Dean

    The Social Sciences, as they relate to the aged and the aging, are discussed. Social gerontology seeks to discover the role of the social environment as a determinant of aging and of the behavior and position of older people in society. In the United States, some 20 million people are over 65 years of age, and the median age of the elderly has…

  1. 撼动80多年生殖和发育研究领域经典学说的实验成果%The Experimental Result of Vibrating the Classical Doctrine for Lasted over 80ys in the Research Field of Reproduction and Development

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    传统观点认为,女性和绝大多数雌性哺乳动物卵母细胞的产生仅发生在胎儿期,然而上海交通大学生命科学技术学院吴际教授(图1)研究团队(包括6名博士研究生,5名硕士研究生)以极富有说服力的实验证据,撼动了占据生殖和发育研究领域80多年的经典学说!

  2. 48 CFR 852.236-80 - Subcontracts and work coordination.

    Science.gov (United States)

    2010-10-01

    ... coordination. 852.236-80 Section 852.236-80 Federal Acquisition Regulations System DEPARTMENT OF VETERANS....236-80 Subcontracts and work coordination. As prescribed in 836.574, insert the following clause: Subcontracts and Work Coordination (APR 1984) (a) Nothing contained in this contract shall be construed...

  3. 47 CFR 80.417 - FCC Rules and Regulations.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false FCC Rules and Regulations. 80.417 Section 80... STATIONS IN THE MARITIME SERVICES Station Documents § 80.417 FCC Rules and Regulations. The Commission's... available on the Commission's web site at www.fcc.gov or ftp.fcc.gov....

  4. Surgical treatment of interrupted aortic arch associated with ventricular septal defect and patent ductus arteriosus in patients over one year of age

    Institute of Scientific and Technical Information of China (English)

    Li Zhiqiang; Li Bin; Fan Xiangming; Su Junwu; Zhang Jing; He Yan; Liu Yinglong

    2014-01-01

    Background Interrupted aortic arch (IAA) is a rare congenital anomaly affecting 1.5% of infants with congenital heart disease.Neonatal repair of IAA is required to avoid irreversible pulmonary vascular lesion.However,in China,patients with IAA associated with ventricular septal defect (VSD) and patent ductus arteriosus (PDA) over one year of age are common.So we investigated the outcome of surgical treatment of IAA with VSD and PDA in patients over one year of age.Methods From January 2009 to December 2012,19 patients with IAA have undergone complete single-stage repair.The patients' mean age was 4.4 years,ranging 1 to 15 years; and their mean weight was 12.8 kg,ranging 4.2 to 36.0 kg.Fifteen IAA were type A,four were type B.Preoperative cardiac catheterization data were available from all patients.Mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR) were measured.The measurements of postoperative pulmonary artery pressure were taken in the operating room at the end of the case.All patients underwent echocardiographic examinations before discharged from the hospital.In addition,cardiac catheterization and echocardiographic examinations were performed during follow-up.Selective brain perfusion through the innominate artery during aortic arch reconstruction was used in all patients.Mean follow-up was (1.6±0.8) years.Results There were two hospital deaths (2/19,11%).One patient died of pulmonary hypertension crisis,and another died of postoperative low cardiac output.Five cases had other main postoperative complications but no postoperative neurologic complications.Seventeen survivors were followed up,and there were no late deaths or reoperation.Mean cross-clamp duration was (85±22) minutes and selective brain perfusion duration was (34±11) minutes.Two patients required delayed sternal closure at two days postoperatively.Intensive care unit and hospital stays were (9±8) days and (47±24) days,respectively.Pressure gradients across

  5. 38 CFR 52.80 - Enrollment, transfer and discharge rights.

    Science.gov (United States)

    2010-07-01

    ... health care program must provide at least 8 hours of operation five days a week. The hours of operation... discharge rights. 52.80 Section 52.80 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) PER DIEM FOR ADULT DAY HEALTH CARE OF VETERANS IN STATE HOMES Standards § 52.80...

  6. Infertility treatment in women over 40 years of age.

    Science.gov (United States)

    Feinman, M A

    1997-06-01

    Women experience a sharp decline in fecundity after the age of 40. Most research points to decreasing oocyte competency and ovarian function as the main causes of this downward trend. Aggressive treatment with in vitro fertilization, laboratory techniques that improve the implantation ability of embryos, and ovum donation can help many of these women achieve healthy pregnancies. Such medical advances are accompanied by new ethical challenges.

  7. Low prevalence of pneumococcal carriage and high serotype and genotype diversity among adults over 60 years of age living in Portugal.

    Directory of Open Access Journals (Sweden)

    Sónia T Almeida

    Full Text Available Pneumococcal disease is frequent at the extremes of age. While several studies have looked at colonization among young children, much less is known among the elderly. We aimed to evaluate pneumococcal carriage among elderly adults living in Portugal. Between April 2010 and December 2012, nasopharyngeal and oropharyngeal swabs of adults over 60 years of age, living in an urban area (n = 1,945 or in a rural area (n = 1,416, were obtained. Pneumococci were isolated by culture-based standard procedures, identified by optochin susceptibility, bile solubility and PCR screening for lytA and cpsA, and characterized by antibiotype, serotype, and MLST. Associations between pneumococcal carriage, socio-demographic and clinical characteristics were evaluated by univariate analysis and multiple logistic regression. The global prevalence of carriage was 2.3% (95% CI: 1.8-2.8. In the multiple logistic regression analysis, smoking, being at a retirement home, and living in a rural area increased the odds of being a pneumococcal carrier by 4.4-fold (95% CI: 1.9-9.2, 2.0-fold (95% CI: 1.1-3.6 and 2.0-fold (95% CI: 1.2-3.5, respectively. Among the 77 pneumococcal isolates, 26 serotypes and 40 STs were identified. The most prevalent serotypes were (in decreasing order 19A, 6C, 22F, 23A, 35F, 11A, and 23B, which accounted, in total, for 60.0% of the isolates. Most isolates (93.5% had STs previously described in the MLST database. Resistance to macrolides, non-susceptibility to penicillin and multidrug resistance were found in 19.5%, 11.7%, and 15.6% of the isolates, respectively. We conclude that the prevalence of pneumococcal carriage in the elderly, in Portugal, as determined by culture-based methods, is low. Serotype and genotype diversity is high. Living in a rural area, in a retirement home, and being a smoker increased the risk of pneumococcal carriage. This study contributes to the establishment of a baseline that may be used to monitor how novel

  8. Ages of Type Ia Supernovae Over Cosmic Time

    CERN Document Server

    Childress, Michael J; Zahid, H Jabran

    2014-01-01

    We derive empirical models for galaxy mass assembly histories, and convolve these with theoretical delay time distribution (DTD) models for Type Ia supernovae (SNe Ia) to derive the distribution of progenitor ages for all SNe Ia occurring at a given epoch of cosmic time. In actively star-forming galaxies, the progression of the star formation rate is shallower than a $t^{-1}$ SN Ia DTD, so mean SN Ia ages peak at the DTD peak in all star-forming galaxies at all epochs of cosmic history. In passive galaxies which have ceased star formation through some quenching process, the SN Ia age distribution peaks at the quenching epoch, which in passive galaxies evolves in redshift to track the past epoch of major star formation. Our models reproduce the SN Ia rate evolution in redshift, the relationship between SN Ia stretch and host mass, and the distribution of SN Ia host masses in a manner qualitatively consistent with observations. Our model naturally predicts that low-mass galaxies tend to be actively star-forming...

  9. Do Sources of Cigarettes among Adolescents Vary by Age over Time?

    Science.gov (United States)

    Lenk, Kathleen M.; Toomey, Traci L.; Shi, Qun; Erickson, Darin J.; Forster, Jean L.

    2014-01-01

    Trends in sources of cigarettes among adolescents were assessed using data from a teen cohort (2000-2006). Five sources--bought from store, got from other teen, stole from others, bought from others, and got from an adult--were measured over time by age. The most common source among all ages was other teens. Fewer teens bought cigarettes from…

  10. Gender-Specific Associations between Perceived Neighbourhood Walkability and Meeting Walking Recommendations When Walking for Transport and Recreation for Czech Inhabitants over 50 Years of Age

    Directory of Open Access Journals (Sweden)

    Jana Pelclová

    2013-12-01

    Full Text Available Few studies have investigated the different effects that the built environment may have on the physical activity behaviours of men and women. Therefore, the aim of this study was to estimate the gender differences in meeting walking recommendations in relation to perceived neighbourhood walkability attributes within the active transportation and leisure-time domains for Czech inhabitants over 50 years of age. The sample included 1,417 men and 1,422 women who were randomly selected. The Abbreviated Neighbourhood Environment Walkability Scale (ANEWS was used to obtain information about the perceived environment. The self-administered long version of the IPAQ was used to assess physical activity levels. When walking for transport, men living in neighbourhoods with high street connectivity (OR = 1.47, CI = 1.04–2.9 and higher traffic and crime safety (OR = 1.28, CI = 1.02–1.6 and women living in neighbourhoods with high proximity (OR = 1.36, CI = 1.04–1.77 and high neighbourhood aesthetics (OR = 1.36, CI = 1.04–1.76 were more likely to meet recommended levels of walking. No environmental attributes were found to significantly influence the accomplishment of walking recommendations by men or women when walking for leisure. The study results indicate the gender-specific associations between transportation-related walking and the environment factors. The consideration of those factors in the design of gender-specific walking interventions for Czech inhabitants may help the interventions to be more effective in promotion of physical activity.

  11. Gender-specific associations between perceived neighbourhood walkability and meeting walking recommendations when walking for transport and recreation for Czech inhabitants over 50 years of age.

    Science.gov (United States)

    Pelclová, Jana; Frömel, Karel; Cuberek, Roman

    2013-12-30

    Few studies have investigated the different effects that the built environment may have on the physical activity behaviours of men and women. Therefore, the aim of this study was to estimate the gender differences in meeting walking recommendations in relation to perceived neighbourhood walkability attributes within the active transportation and leisure-time domains for Czech inhabitants over 50 years of age. The sample included 1,417 men and 1,422 women who were randomly selected. The Abbreviated Neighbourhood Environment Walkability Scale (ANEWS) was used to obtain information about the perceived environment. The self-administered long version of the IPAQ was used to assess physical activity levels. When walking for transport, men living in neighbourhoods with high street connectivity (OR = 1.47, CI = 1.04-2.9) and higher traffic and crime safety (OR = 1.28, CI = 1.02-1.6) and women living in neighbourhoods with high proximity (OR = 1.36, CI = 1.04-1.77) and high neighbourhood aesthetics (OR = 1.36, CI = 1.04-1.76) were more likely to meet recommended levels of walking. No environmental attributes were found to significantly influence the accomplishment of walking recommendations by men or women when walking for leisure. The study results indicate the gender-specific associations between transportation-related walking and the environment factors. The consideration of those factors in the design of gender-specific walking interventions for Czech inhabitants may help the interventions to be more effective in promotion of physical activity.

  12. [Distribution of the different patterns of aging over the system of animal world].

    Science.gov (United States)

    Popov, I Iu

    2011-01-01

    Since the system of animal world reflects evolutionary trends, an analysis of distribution of patterns of aging over this system provides information on the causes of the formation of differences among them. In this paper the system of the main animal groups in form of a table is presented, and the distribution of patterns demonstrating minimum and maximum of aging is discussed. Meanwhile the colonial animals are considered as a "minimum of aging", the animals demonstrating drastic self-liquidation after reproduction are considered as a "maximum of aging" (the most well-known example is the pink salmon). It is shown, that as far as the degree of difference from the simplest ancestor increases in process of evolution, the increase of the manifestations of aging takes place. Slow aging of relatively simple organisms cannot be a direct source of measures to prevent aging of complex ones.

  13. Changes in prevalence of obesity and high waist circumference over four years across European regions: the European male ageing study (EMAS).

    Science.gov (United States)

    Han, Thang S; Correa, Elon; Lean, Michael E J; Lee, David M; O'Neill, Terrence W; Bartfai, György; Forti, Gianni; Giwercman, Aleksander; Kula, Krzysztof; Pendleton, Neil; Punab, Margus; Rutter, Martin K; Vanderschueren, Dirk; Huhtaniemi, Ilpo T; Wu, Frederick C W; Casanueva, Felipe F

    2017-02-01

    -transitional countries. These regional differences in increased prevalence of waist circumference ≥ 102 cm were more pronounced in men aged 60-79 years than in those aged 40-59 years. Overall there was an increase in the prevalence of obesity (body mass index  ≥ 30 kg/m(2)) over 4.3 years (between 5.3 and 6.1 %) with no significant regional differences at any age. Mid-upper arm muscle area declined during follow-up with the greatest decline among men from North-East European cities. In conclusion, increasing waist circumference is dissociated from change in body mass index and most rapid among men living in cities from transitional North-East European countries, presumably driven by economic and socio-political changes. Information on women would also be of value and it would be of interest to relate the changes in adiposity to dietary and other behavioural habits.

  14. Finitude, Aging and Subjectivity

    Directory of Open Access Journals (Sweden)

    Mariele Rodrigues Correa

    2014-11-01

    Full Text Available The purpose of this article is to analyze the relationship of man with death and its deployment in subjectivity and in aging. With this intent, we first present a brief history of the vision of death over time and after an analysis of the process of aging and dying according to the logic of biopolitical management. With death and old age increasingly distant from the horizons of life, subjectivity has been weakened. Thus, incorporating these aspects as part of existence constitutes one of the challenges to the thought as well as to the building of the self.  

  15. The comparison between measurement of open apices of third molars and Demirjian stages to test chronological age of over 18 year olds in living subjects.

    Science.gov (United States)

    Cameriere, R; Ferrante, L; De Angelis, D; Scarpino, F; Galli, F

    2008-11-01

    This paper concerns a method for assessing adult age based on the relationship between age and the third molar maturity index (I(3M)), which is related to the measurement of the open apices of the third molar. Furthermore, this method was compared to those based on Demirjian's stages G and H. The sample consisted of 906 Caucasian individuals aged between 14 and 23 years (53.6% females and 46.4% males). Orthopantomographs were analyzed by two observers and calibrated by means of the concordance correlation coefficient for the reproducibility of the third molar maturity index (I(3M)) and kappa statistics for reproducibility of the Demirjian stages. Probabilities for an individual to be older than 18 years of age (adult age) were derived using the measurements of the third molar maturity index (I(3M)). These results were exploited to set out a threshold value to assign an individual to juvenile or adult age. A cutoff value of I(3M) = 0.08 was taken. The sensitivity of this test was 70% and specificity was 98%. Furthermore, the proportion of individuals with a correct classification was 83%. The results of the test showed a better specificity when compared to the choice of stage G and a better sensitivity when compared to the choice of stage H for adult age.

  16. Efficient regenerative wavelength conversion at 10Gbit/s over C- and L-band (80nm span) using a Mach-Zehnder interferometer with monolithically integrated semiconductor optical amplifiers

    DEFF Research Database (Denmark)

    Dülk, M.; Fischer, St.; Gamper, E.;

    2000-01-01

    A demonstration is presented of 10Gbit/s 2R regenerative wavelength up- and down-conversion within the C-band as well as up-conversion to the L-band using a monolithically integrated Mach-Zehnder interferometer module with semiconductor optical amplifiers (MZI-SOAs). The converted output signals ...

  17. Polysorbate 80 and Helicobacter pylori: a microbiological and ultrastructural study

    Directory of Open Access Journals (Sweden)

    Figura Natale

    2012-09-01

    Full Text Available Abstract Background The frequent occurrence of chemoresistant strains reduces the chances of eradication of H. pylori infection and prompted the investigation of non-antibiotic substances active against this organism. Some surfactants enhance the effectiveness of antibiotics for their permeabilizing properties towards bacteria. We examined the antimicrobial activity to H. pylori of the surfactant polysorbate 80, used alone and in association with amoxicillin, clarithromycin, metronidazole, levofloxacin and tetracycline. We also aimed to study the ultrastructural alterations caused upon H. pylori by polysorbate 80, alone and in combination with antibiotics. Twenty-two H. pylori strains were tested using the broth dilution method. After incubation, broth from each dilution was subcultured onto agar enriched with foetal bovine serum to determine the minimum bactericidal concentration (MBC. Synergistic effect of polysorbate 80 with antibiotics was investigated by the broth dilution and disc diffusion techniques. Ultrastructural alterations of organisms treated with polysorbate 80, alone and in association with antibiotics were analyzed by transmission electron microscopy. Results MBCs of polysorbate 80 ranged from 2.6 (1.1 μg/ml to 32 (0 μg/ml. Polysorbate 80 exerted a synergistic effect when associated with metronidazole and clarithromycin: polysorbate 80 and metronidazole MBCs decreased by ≥ 4 fold; clarithromycin MBCs for two resistant strains decreased by 20 and 1000 times. The principal alteration caused by polysorbate 80 consisted in the detachment of the outer membrane of bacteria. Conclusions The bactericidal activity of polysorbate 80 and the synergistic effect of the association with metronidazole and clarithromycin could be useful in the treatment of H. pylori infection.

  18. 高龄双胎妊娠的围产结局分析%Perinatal outcomes in women aged 35 and over with twin pregnancy

    Institute of Scientific and Technical Information of China (English)

    陈敏玲; 王子莲; 凌家炜; 韩振艳

    2010-01-01

    目的 探讨高龄双胎妊娠的围产结局.方法 回顾性分析我院69例高龄双胎病例,随机对照176例非高龄双胎的临床资料,比较两组在妊娠并发症、妊娠合并症、和胎儿预后等方面的差异.结果 ①高龄组接受辅助生育技术受孕比例显著高于非高龄对照组(P<0.05);②高龄组<32孕周早产发生率明显高于对照组(P<0.05),而其他并发症及合并症两组间未见显著性差异;③高龄组以极低出生体重儿(<1500 g)比例显著高于对照组(P<0.05).高龄组新生儿窒息率及胎儿窘迫发生率明显增高(P<0.05).结论 高龄双胎妊娠不良妊娠结局主要与<32孕周的严重早产、极低体重儿、新生儿窒息及胎儿窘迫密切相关,应针对性加强高龄双胎的围生期监护,警惕严重早产的发生.%Objective The aim of this study is to present perinataloutcomes of twin gestations in older women. Methods We conducted a retrospective cohort study of 69 cases of twin pregnancies maternal age 35 years and older( study group)in our department, compared with 176 twin pregnancies cases of maternal age less than 35 years( control group). Results ①Conceptions after assisted reproductive technology were significantly higher in study group(P<0.05 ). ②The rate of preterm labour lower than 32 gestational weeks was significantly higher in the study group(P<0.05). The other complications rate did not differ singnificantly from the control groups. (3) The very low birth weight ( VLBW < 1,500 g) rate was significantly higher in the study group ( P<0.05 ), the rate of neonatal asphyxia and fetal distress were statistically significant higher in study group (P<0.05). Conclusion Advanced maternal age was related with higher incidence of the severe preterm labour(<32 gestational weeks) ,the very low birth weight(<1,500 g) ,fetal distress,neonatal asphyxia. It is important to close monitoring during perinatal period in women aged 35 and

  19. Subliminal strengthening: improving older individuals' physical function over time with an implicit-age-stereotype intervention.

    Science.gov (United States)

    Levy, Becca R; Pilver, Corey; Chung, Pil H; Slade, Martin D

    2014-12-01

    Negative age stereotypes that older individuals assimilate from their culture predict detrimental outcomes, including worse physical function. We examined, for the first time, whether positive age stereotypes, presented subliminally across multiple sessions in the community, would lead to improved outcomes. Each of 100 older individuals (age=61-99 years, M=81) was randomly assigned to an implicit-positive-age-stereotype-intervention group, an explicit-positive-age-stereotype-intervention group, a combined implicit- and explicit-positive-age-stereotype-intervention group, or a control group. Interventions occurred at four 1-week intervals. The implicit intervention strengthened positive age stereotypes, which strengthened positive self-perceptions of aging, which, in turn, improved physical function. The improvement in these outcomes continued for 3 weeks after the last intervention session. Further, negative age stereotypes and negative self-perceptions of aging were weakened. For all outcomes, the implicit intervention's impact was greater than the explicit intervention's impact. The physical-function effect of the implicit intervention surpassed a previous study's 6-month-exercise-intervention's effect with participants of similar ages. The current study's findings demonstrate the potential of directing implicit processes toward physical-function enhancement over time.

  20. A T cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years.

    Directory of Open Access Journals (Sweden)

    Richard D Antrobus

    Full Text Available BACKGROUND: Current influenza vaccines have reduced immunogenicity and are of uncertain efficacy in older adults. We assessed the safety and immunogenicity of MVA-NP+M1, a viral-vectored influenza vaccine designed to boost memory T cell responses, in a group of older adults. METHODS: Thirty volunteers (aged 50-85 received a single intramuscular injection of MVA-NP+M1 at a dose of 1·5×10(8 plaque forming units (pfu. Safety and immunogenicity were assessed over a period of one year. The frequency of T cells specific for nucleoprotein (NP and matrix protein 1 (M1 was determined by interferon-gamma (IFN-γ ELISpot, and their phenotypic and functional properties were characterized by polychromatic flow cytometry. In a subset of M1-specific CD8(+ T cells, T cell receptor (TCR gene expression was evaluated using an unbiased molecular approach. RESULTS: Vaccination with MVA-NP+M1 was well tolerated. ELISpot responses were boosted significantly above baseline following vaccination. Increases were detected in both CD4(+ and CD8(+ T cell subsets. Clonality studies indicated that MVA-NP+M1 expanded pre-existing memory CD8(+ T cells, which displayed a predominant CD27(+CD45RO(+CD57(-CCR7(- phenotype both before and after vaccination. CONCLUSIONS: MVA-NP+M1 is safe and immunogenic in older adults. Unlike seasonal influenza vaccination, the immune responses generated by MVA-NP+M1 are similar between younger and older individuals. A T cell-inducing vaccine such as MVA-NP+M1 may therefore provide a way to circumvent the immunosenescence that impairs routine influenza vaccination. TRIAL REGISTRATION: ClinicalTrials.gov NCT00942071.

  1. 21 CFR 110.80 - Processes and controls.

    Science.gov (United States)

    2010-04-01

    ... frozen foods in a frozen state. (iii) Maintaining hot foods at 140 °F (60 °C) or above. (iv) Heat... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Processes and controls. 110.80 Section 110.80 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD...

  2. Analysis of bone mineral density measured with QUS and SPA in 14851 residents aged 20-80 years old in Yuxi%云南玉溪市14851例20~80岁超声及单光子骨密度调查分析

    Institute of Scientific and Technical Information of China (English)

    林明; 靳平燕; 孙添明

    2011-01-01

    Objective To explore the peak bone mineral density (PBD) measured with quantitative ultrasound (QUS) and the normal reference range in normal people in Yuxi, and to compare that with the BMD measured with SPA in our hospital to know the correlation of the results. Methods BMD results with either Sahara QUS or SPA measurement were retrospectively analyzed in 14851 cases in the Health Center of People' s Hospital of Yuxi city from January 2008 to June 2010. The patients whose BMD could be affected by abnormal factors were not included. PEMS was analyzed according to the age stratification. Results In Yuxi city, PBD in normal males measured with QUS appeared at 25 years old (0.6895 ±0. 1411 g/cm2) and in females appeared at 24 years old (0. 6884 ± 0. 1084 g/cm2) , respectively. Statistic difference existed comparing to PBD at 25-30 years old (0. 581 ± 0. 112 g/cm2) provided by the company. PBD in normal males measured with SPA appeared at 30 years old (0. 6933 ±0. 0815 g/cm2 ) and in females appeared at 32 years old (0. 6160 ±0.0728 g/cm2 ). Conclusion The PBD measured with QUS or SPA is different due to the difference of the method and the measurement sites. PBD is different in different gender and age groups. There is no comparability between two measure methods at the same age group, but there is nice linear correlation. It can reflect personal BMD by making right reference range.%目的 探讨玉溪市正常人群定量超声(QUS)峰值骨密度(PBD)及正常参考区间并与本院传统的单光子(SPA)骨密度(BMD)检测结果进行对比,了解二者相关性和结果传承.方法 回顾性分析玉溪市人民医院健康体检中心2008年1月~2010年6月14851例Sahara超声及单光子骨密度仪检测的骨密度结果,并从体检系统中筛出影响骨密度因素的异常患者,PEMS按年龄分层进行统计分析.结果 玉溪市正常人QUS男女PBD分别出现于25岁(0.6895±0.1411 g/cm2)及24岁(0.6884±0.1084 g/cm2),与厂家提供的25

  3. 33 CFR 80.1144 - Bodega and Tomales Bay, CA.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Bodega and Tomales Bay, CA. 80... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1144 Bodega and Tomales Bay, CA. (a... of Bodega Harbor North Breakwater to Bodega Harbor Entrance Light 1....

  4. Polysorbate 80 and polymyxin B inhibit Stenotrophomonas maltophilia biofilm.

    Science.gov (United States)

    Malinowski, Adam M; McClarty, Bryan M; Robinson, Carolyn; Spear, William; Sanchez, Maria; Sparkes, Timothy C; Brooke, Joanna S

    2017-02-01

    Stenotrophomonas maltophilia is an opportunistic multiple-drug-resistant human pathogen that forms biofilms on implanted medical devices. We examined the potential inhibitory activity of polysorbate 80 and polymyxin B against S. maltophilia. A combination of subMIC polymyxin B and polysorbate 80 was the most effective inhibitor of growth and biofilm formation.

  5. Cardiovascular risk in men aged over 40 in Boa Vista, Brazil

    Directory of Open Access Journals (Sweden)

    Mário Maciel de Lima

    2016-01-01

    Conclusions: Our study highlights a worrying trend in increasing obesity and hypertension, most likely associated with increasingly poor diet and reduced participation in exercises. As the Brazilian population ages, this will drive increasing rates of cardiovascular mortality unless these trends are reversed. This study suggests that such campaigns should focus on men over the age of 40, who are married or divorced and of lower income.

  6. 47 CFR 80.1153 - Station log and radio watches.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Station log and radio watches. 80.1153 Section... SERVICES STATIONS IN THE MARITIME SERVICES Voluntary Radio Installations General § 80.1153 Station log and radio watches. (a) Licensees of voluntary ships are not required to maintain radio station logs....

  7. Sociodemographic and Lifestyle Statistics of Oldest Old People (>80 Years Living in Ikaria Island: The Ikaria Study

    Directory of Open Access Journals (Sweden)

    Demosthenes B. Panagiotakos

    2011-01-01

    Full Text Available Background. There are places around the world where people live longer and they are active past the age of 100 years, sharing common behavioral characteristics; these places (i.e., Sardinia in Italy, Okinawa in Japan, Loma Linda in California and Nicoya Peninsula in Costa Rica have been named the “Blue Zones”. Recently it was reported that people in Ikaria Island, Greece, have also one of the highest life expectancies in the world, and joined the “Blue Zones”. The aim of this work work was to evaluate various demographic, lifestyle and psychological characteristics of very old (>80 years people participated in Ikaria Study. Methods. During 2009, 1420 people (aged 30+ men and women from Ikaria Island, Greece, were voluntarily enrolled in the study. For this work, 89 males and 98 females over the age of 80 yrs were studied (13% of the sample. Socio-demographic, clinical, psychological and lifestyle characteristics were assessed using standard questionnaires and procedures. Results. A large proportion of the Ikaria Study's sample was over the age of 80; moreover, the percent of people over 90 were much higher than the European population average. The majority of the oldest old participants reported daily physical activities, healthy eating habits, avoidance of smoking, frequent socializing, mid-day naps and extremely low rates of depression. Conclusion. Modifiable risk factors, such as physical activity, diet, smoking cessation and mid-day naps, might depict the “secrets” of the long-livers; these findings suggest that the interaction of environmental, behavioral together with clinical characteristics may determine longevity. This concept must be further explored in order to understand how these factors relate and which are the most important in shaping prolonged life.

  8. Transitions in cognitive test scores over 5 and 10 years in elderly people: Evidence for a model of age-related deficit accumulation

    Directory of Open Access Journals (Sweden)

    Rockwood Kenneth

    2008-02-01

    Full Text Available Abstract Background On average, health worsens with age, but many people have periods of improvement. A stochastic model provides an excellent description of how such changes occur. Given that cognition also changes with age, we wondered whether the same model might also describe the accumulation of errors in cognitive test scores in community-dwelling older adults. Methods In this prospective cohort study, 8954 older people (aged 65+ at baseline from the Canadian Study of Health and Aging were followed for 10 years. Cognitive status was defined by the number of errors on the 100-point Modified Min-Mental State Examination. The error count was chosen to parallel the deficit count in the general model of aging, which is based on deficit accumulation. As with the deficit count, a Markov chain transition model was employed, with 4 parameters. Results On average, the chance of making errors increased linearly with the number of errors present at each time interval. Changes in cognitive states were described with high accuracy (R2 = 0.96 by a modified Poisson distribution, using four parameters: the background chance of accumulating additional errors, the chance of incurring more or fewer errors, given the existing number, and the corresponding background and incremental chances of dying. Conclusion The change in the number of errors in a cognitive test corresponded to a general model that also summarizes age-related changes in deficits. The model accounts for both improvement and deterioration and appears to represent a clinically relevant means of quantifying how various aspects of health status change with age.

  9. Le vieillissement de la flotte pétrolière et les marées noires dans les années 80 Aging of the Oil Tanker Fleet and Major Oil Spills in the 1980s

    Directory of Open Access Journals (Sweden)

    Smets H.

    2006-11-01

    Full Text Available Le vieillissement de la flotte pétrolière au cours des années à venir pourrait entraîner un accroissement du nombre et du volume des marées noires. L'examen de divers scénarios de contraction de la flotte pétrolière et de mise hors service des navires âgés permet cependant de conclure que la fréquence et le volume des marées noires en 1990 ne devraient pas excéder de façon très sensible les valeurs observées actuellement et pourraient même être inférieurs. The aging of the oil tanker fleet in the years to come could result in an increase in the number and volume of major oil spills. However, an examination of different scenarios for reducing the tanker fleet and for deactivating the older ships leads to the conclusion that the frequency and volume of major oil spills in 1990 should not be appreciably greater than the levels now observed and even that they could be somewhat less.

  10. Appearance of strong absorbers and fluorophores in limonene-O3 secondary organic aerosol due to NH4+-mediated chemical aging over long time scales

    Science.gov (United States)

    Bones, David L.; Henricksen, Dana K.; Mang, Stephen A.; Gonsior, Michael; Bateman, Adam P.; Nguyen, Tran B.; Cooper, William J.; Nizkorodov, Sergey A.

    2010-03-01

    This study investigated long-term chemical aging of model biogenic secondary organic aerosol (SOA) prepared from the ozonolysis of terpenes. Techniques including electrospray ionization mass spectrometry (ESI-MS), UV-visible spectroscopy, Fourier transform infrared (FTIR) spectroscopy, NMR, and three-dimensional fluorescence were used to probe the changes in chemical composition of SOA collected by impaction on substrates and also of aqueous extracts of SOA. The addition of ammonium ions or amino acids to limonene SOA reproducibly produced orange-colored species that strongly absorbed visible radiation and fluoresced at UV and visible wavelengths. Simultaneous addition of H2SO4 to the SOA aqueous extracts inhibited this color transformation. These observations suggest the existence of aging processes leading to heavily conjugated molecules containing organic nitrogen. The presence of nitrogen in the chromophores was confirmed by the dependence of the absorption and fluorescence spectra on the amino acids added. In contrast to the strong change in the absorption and fluorescence spectra, there was no significant change in the ESI-MS, FTIR, and NMR spectra, suggesting that the chromophores were minor species in the aged SOA. Aqueous extracts of aged limonene + NH4+ SOA were characterized by an effective base-e absorption coefficient of ˜3 L g-1 cm-1 at 500 nm. Assuming particulate matter concentrations typical of polluted rural air gives an upper limit of 0.2 M m-1 for the aerosol absorption coefficient due to the aged limonene oxidation products. Biogenic SOA can therefore become weakly absorbing if they undergo aging in the presence of NH4+-containing aerosol.

  11. The Age of Reason: Financial Decisions over the Life-Cycle with Implications for Regulation

    OpenAIRE

    Laibson, David I.; Agarwal, Sumit; Driscoll, John C.; Gabaix, Xavier

    2009-01-01

    Many consumers make poor financial choices and older adults are particularly vulnerable to such errors. About half of the population between ages 80 and 89 either has dementia or a medical diagnosis of “cognitive impairment without dementia.†We study lifecycle patterns in financial mistakes using a proprietary database that measures ten different types of credit behavior. Financial mistakes include suboptimal use of credit card balance transfer offers, misestimation of the value of one’...

  12. Exaptation, serendipity and aging.

    Science.gov (United States)

    Andriani, Pierpaolo

    2017-01-12

    The paper shows the importance of serendipity and exaptation in selected key moments of ageing research and argue that rationalistic dominant models in scientific research have masked the importance of reverse models of discovery based on serendipity and exaptation. I ask why this is the case and analyze three contributing factors: unprestatability of the functions of technologies, multidimensionality and astronomical complexity of the space over which biological reactions occurs and role of scientific paradigms in channeling research toward incrementalism. Empirical evidence of the limits of the rationalistic models are presented next. I close the paper by discussing the implications for aging research.

  13. No intra-locus sexual conflict over reproductive fitness or ageing in field crickets.

    Directory of Open Access Journals (Sweden)

    Felix Zajitschek

    Full Text Available Differences in the ways in which males and females maximize evolutionary fitness can lead to intra-locus sexual conflict in which genes delivering fitness benefits to one sex are costly when expressed in the other. Trade-offs between current reproductive effort and future reproduction and survival are fundamental to the evolutionary biology of ageing. This leads to the prediction that sex differences in the optimization of age-dependent reproductive effort may generate intra-locus sexual conflict over ageing rates. Here we test for intra-locus sexual conflict over age-dependent reproductive effort and longevity in the black field cricket, Teleogryllus commodus. Using a half-sib breeding design, we show that the most important components of male and female reproductive effort (male calling effort and the number of eggs laid by females were positively genetically correlated, especially in early adulthood. However, the genetic relationships between longevity and reproductive effort were different for males and females, leading to low genetic covariation between male and female longevity. The apparent absence of intra-locus sexual conflict over ageing suggests that male and female longevity can evolve largely independently of one another.

  14. Measurement Invariance of Big-Five Factors over the Life Span: ESEM Tests of Gender, Age, Plasticity, Maturity, and La Dolce Vita Effects

    Science.gov (United States)

    Marsh, Herbert W.; Nagengast, Benjamin; Morin, Alexandre J. S.

    2013-01-01

    This substantive-methodological synergy applies evolving approaches to factor analysis to substantively important developmental issues of how five-factor-approach (FFA) personality measures vary with gender, age, and their interaction. Confirmatory factor analyses (CFAs) conducted at the item level often do not support a priori FFA structures, due…

  15. Health screening - men age 65 and older

    Science.gov (United States)

    Health maintenance visit - men - over age 65; Physical exam - men - over age 65; Yearly exam - men - over age 65; Checkup - men - over age 65; Men's health - over age 65; Preventive care exam - men - over ...

  16. Wavelength conversion from C- to L-band at 10 Gbit/s including transmission over 80 km of SSMF

    DEFF Research Database (Denmark)

    Poulsen, Henrik Nørskov; Buxens Azcoaga, Alvaro Juan; Clausen, Anders

    2000-01-01

    As the need for capacity increases, means to accommodate the growth is getting increasingly important. Hence, higher bit rates and an ever increasing number of WDM channels is being employed. This has led to the introduction of the L-band (ranging from 1570 to 1610 nm) as the new transmission...... window, opening up for-in conjunction with the C-band-an astonishing 80 nm of available bandwidth. However, as the number of wavelength channels increases, the need for wavelength conversion is becoming ever more pronounced. To perform the wavelength conversion, interferometric structures...... such as the monolithically integrated Mach-Zehnder interferometers (SOA-MZI) using semiconductor optical amplifiers as phase-shifting elements have proven excellent candidates. Here we present the conversion and transmission properties of a fully packaged device capable of wavelength conversion from C- to L-band having more...

  17. Antibody persistence and immune memory 4 years post-vaccination with combined hepatitis A and B vaccine in adults aged over 40 years.

    Science.gov (United States)

    Chlibek, Roman; von Sonnenburg, Frank; Van Damme, Pierre; Smetana, Jan; Tichy, Petr; Gunapalaiah, Bhavyashree; Leyssen, Maarten; Jacquet, Jeanne-Marie

    2011-01-01

    Persistence of immune response was assessed in adults aged >40 years (N = 596) following primary vaccination with combined hepatitis A/B vaccine or concomitant monovalent hepatitis A and B vaccines. Anti-hepatitis A virus antibody responses persisted for at least 4 years regardless of the vaccine used, with anti-hepatitis B surface antibody responses higher and more sustained in subjects who received the combined hepatitis A/B vaccine. Response rates to an additional dose of the same vaccine(s) used for priming were high.

  18. Weldability and SAW welding wire of X80 pipeline steel

    Institute of Scientific and Technical Information of China (English)

    Huang Zhijun; Hu Lunji; Miao Kai; Zhang Xiaofeng; Chen Fu

    2006-01-01

    Weldability test was carried out on the newly developed fine grain, low sulphur, high strength and high toughness pipeline steel of X80 and its matching SA W wire. Test of maximum hardness in welding heat-affected zone and test of Y groove cracking show that X80 steel features low hardenability and good cracking resistance. The submerged arc welding joint made with the newly developed low carbon and multi-alloyed SA W wire of WGX2 exhibits a little higher strength than the base metal, qualified bending performance, under maximum limitation hardness and good impact toughness, which can completely meet the technical requirement of X80 steel. Despite somewhat coarsening the grain size in welding heat-affected zone is still much finer than that of traditional steels, and the microstructure in weld metal is almost full acicular ferrite. The results show that X80 steel and WGX2 wire are of great weldability.

  19. Lens Endogenous Peptide αA66-80 Generates Hydrogen Peroxide and Induces Cell Apoptosis.

    Science.gov (United States)

    Raju, Murugesan; Santhoshkumar, Puttur; Sharma, K Krishna

    2017-02-01

    In previous studies, we reported the presence of a large number of low-molecular-weight (LMW) peptides in aged and cataract human lens tissues. Among the LMW peptides, a peptide derived from αA-crystallin, αA66-80, was found in higher concentration in aged and cataract lenses. Additional characterization of the αA66-80 peptide showed beta sheet signature, and it formed well-defined unbranched fibrils. Further experimental data showed that αA66-80 peptide binds α-crystallin, impairs its chaperone function, and attracts additional crystallin proteins to the peptide α-crystallin complex, leading to the formation of larger light scattering aggregates. It is well established that Aβ peptide exhibits cell toxicity by the generation of hydrogen peroxide. The αA66-80 peptide shares the principal properties of Aβ peptide. Therefore, the present study was undertaken to determine whether the fibril-forming peptide αA66-80 has the ability to generate hydrogen peroxide. The results show that the αA66-80 peptide generates hydrogen peroxide, in the amount of 1.2 nM H2O2 per µg of αA66-80 peptide by incubation at 37°C for 4h. We also observed cytotoxicity and apoptotic cell death in αA66-80 peptide-transduced Cos7 cells. As evident, we found more TUNEL-positive cells in αA66-80 peptide transduced Cos7 cells than in control cells, suggesting peptide-mediated cell apoptosis. Additional immunohistochemistry analysis showed the active form of caspase-3, suggesting activation of the caspase-dependent pathway during peptide-induced cell apoptosis. These results confirm that the αA66-80 peptide generates hydrogen peroxide and promotes hydrogen peroxide-mediated cell apoptosis.

  20. Birth cohort differences in fluid cognition in old age: comparisons of trends in levels and change trajectories over 30 years in three population-based samples.

    Science.gov (United States)

    Karlsson, Peter; Thorvaldsson, Valgeir; Skoog, Ingmar; Gudmundsson, Pia; Johansson, Boo

    2015-03-01

    Later-born cohorts of older adults tend to outperform earlier born on fluid cognition (i.e., Flynn effect) when measured at the same chronological ages. We investigated cohort differences in level of performance and rate of change across three population-based samples born in 1901, 1906, and 1930, drawn from the Gerontological and Geriatric Population Studies in Gothenburg, Sweden (H70), and measured on tests of logical reasoning and spatial ability at ages 70, 75, and 79 years. Estimates from multiple-group latent growth curve models (LGCM) revealed, in line with previous studies, substantial differences in level of performance where later-born cohorts outperformed earlier born cohorts. Somewhat surprisingly, later-born cohorts showed, on average, a steeper decline than the earlier-born cohort. Gender and education only partially accounted for observed cohort trends. Men outperformed women in the 1906 and 1930 cohorts but no difference was found in the 1901 cohort. More years of education was associated with improved performance in all three cohorts. Our findings confirm the presence of birth cohort effects also in old age but indicate a faster rate of decline in later-born samples. Potential explanations for these findings are discussed.

  1. Immunogenicity and reactogenicity of a recombinant hepatitis B vaccine in subjects over age of forty years and response of a booster dose among nonresponders

    Institute of Scientific and Technical Information of China (English)

    Kunal Das; R. K. Gupta; V. Kumar, P.Kar

    2003-01-01

    AIM: The study was initiated to evaluate the reactogenicity and immunogenicity of a recombinant hepatitis B vaccine in age group >40 years and to study the response of a single booster dose in primary non-responders to the hepatitis B vaccination.METHODS: A total of 102 volunteers without markers of hepatitis B infection (negative for HBsAg, anti-HBc antibody,HBeAg and anti-HBs antibody) received 20 pg of recombinant HB vaccine intramuscularly at 0, 1, and 6 months. Anti HBs titers were evaluated by a quantitative Elisa kit at 90 and 210 days. A booster dose of 20 pg HB vaccine was given after 6 months of the 3rd vaccine dose to the 15 nonresponders and anti-HBs titers were measured after 1 month.RESULTS: Seroprotection (anti-HBs GMT3 10 IU/L) was achieved in 85.3 % (87/102) volunteers. The mean GMT titers of the vaccine responders was 136.1 IU/L. Of the seroprotected individuals, there were 32.4 % (33/102) hyporesponders (antiHBs titers <10-99 mlU/ml) and 52.9 % (54/102) were responders (anti-HBs titers >100 IU/L). All the non-responders (15/15) responded to a single dose of the booster dose of recombinant HB vaccine and their mean anti-HBs antibody titers were more than 100.5 mIU/ml after the booster dose.CONCLUSION: Recombinant hepatitis B vaccine offers good seroprotection in the age group >40 years and has a good safety profile. A single booster dose after 6 months in primary non-responders leads to good seroprotective anti-HBs antibody titers. However, larger population based studies are needed to evaluate the role of a booster dose in selected group of non-responders and whether such an approach will be cost effective.

  2. Short-term blood pressure variability over 24 h and target organ damage in middle-aged men and women.

    LENUS (Irish Health Repository)

    Madden, J M

    2015-03-19

    Blood pressure variability (BPV) has been associated with cardiovascular events; however, the prognostic significance of short-term BPV remains uncertain. As uncertainty also remains as to which measure of variability most accurately describes short-term BPV, this study explores different indices and investigates their relationship with subclinical target organ damage (TOD). We used data from the Mitchelstown Study, a cross-sectional study of Irish adults aged 47-73 years (n=2047). A subsample (1207) underwent 24-h ambulatory BP monitoring (ABPM). As measures of short-term BPV, we estimated the s.d., weighted s.d. (wSD), coefficient of variation (CV) and average real variability (ARV). TOD was documented by microalbuminuria and electrocardiogram (ECG) left ventricular hypertrophy (LVH). There was no association found between any measure of BPV and LVH in both unadjusted and fully adjusted logistic regression models. Similar analysis found that ARV (24 h, day and night), s.d. (day and night) and wSD were all univariately associated with microalbuminuria and remained associated after adjustment for age, gender, smoking, body mass index (BMI), diabetes and antihypertensive treatment. However, when the models were further adjusted for the mean BP the association did not persist for all indices. Our findings illustrate choosing the appropriate summary measure, which accurately captures that short-term BPV is difficult. Despite discrepancies in values between the different measures, there was no association between any indexes of variability with TOD measures after adjustment for the mean BP.Journal of Human Hypertension advance online publication, 19 March 2015; doi:10.1038\\/jhh.2015.18.

  3. Age-associated losses of brain volume predict longitudinal cognitive declines over 8 to 20 years.

    Science.gov (United States)

    Rabbitt, Patrick; Ibrahim, Said; Lunn, Mary; Scott, Marietta; Thacker, Neil; Hutchinson, Charles; Horan, Michael; Pendleton, Neil; Jackson, Alan

    2008-01-01

    Absolute differences in global brain volume predict differences in cognitive ability among healthy older adults. However, absolute differences confound lifelong differences in brain size with amounts of age-related shrinkage. Measurements of cerebrospinal fluid (CSF) volume were made to estimate age-related shrinkage in 93 healthy volunteers aged 63 to 86 years. Their current levels of brain shrinkage predicted their amounts of decline over the previous 8 to 20 years on repeated assessments during a longitudinal study on the Cattell "Culture Fair" Intelligence Test, on two tests of information processing speed, and marginally on the Wechsler Adult Intelligence Scale (D. Wechsler, 1981), but not on three memory tests. Loss of brain volume is an effective marker both for current cognitive status and for amounts and rates of previous age-related cognitive losses.

  4. Aged-Related Changes in Body Composition and Association between Body Composition with Bone Mass Density by Body Mass Index in Chinese Han Men over 50-year-old.

    Directory of Open Access Journals (Sweden)

    Ying Jiang

    Full Text Available Aging, body composition, and body mass index (BMI are important factors in bone mineral density (BMD. Although several studies have investigated the various parameters and factors that differentially influence BMD, the results have been inconsistent. Thus, the primary goal of the present study was to further characterize the relationships of aging, body composition parameters, and BMI with BMD in Chinese Han males older than 50 years.The present study was a retrospective analysis of the body composition, BMI, and BMD of 358 Chinese male outpatients between 50 and 89 years of age that were recruited from our hospital between 2009 and 2011. Qualified subjects were stratified according to age and BMI as follows: 50-59 (n = 35, 60-69 (n = 123, 70-79 (n = 93, and 80-89 (n = 107 years of age and low weight (BMI: < 20 kg/m2; n = 21, medium weight (20 ≤ BMI < 24 kg/m2; n = 118, overweight (24 ≤ BMI < 28 kg/m2; n = 178, and obese (BMI ≥ 28 kg/m2; n = 41. Dual-energy X-ray absorptiometry (DEXA was used to assess bone mineral content (BMC, lean mass (LM, fat mass (FM, fat-free mass (FFM, lumbar spine (L1-L4 BMD, femoral neck BMD, and total hip BMD. Additionally, the FM index (FMI; FM/height2, LM index (LMI; LM/height2, FFM index (FFMI; [BMC+LM]/height2, percentage of BMC (%BMC; BMC/[BMC+FM+LM] × 100%, percentage of FM (%FM; FM/[BMC+FM+LM] × 100%, and percentage of LM (%LM; LM/(BMC+FM+LM × 100% were calculated. Osteopenia or osteoporosis was identified using the criteria and T-score of the World Health Organization.Although there were no significant differences in BMI among the age groups, there was a significant decline in height and weight according to age (p < 0.0001 and p = 0.0002, respectively. The LMI and FFMI also declined with age (both p < 0.0001 whereas the FMI exhibited a significant increase that peaked in the 80-89-years group (p = 0.0145. Although the absolute values of BMC and LM declined with age (p = 0.0031 and p < 0

  5. The Gold Standard Program for Smoking Cessation is Effective for Participants Over 60 Years of Age

    DEFF Research Database (Denmark)

    Flamand, Mette Kehlet; Schroeder, Torben V; Tønnesen, Hanne

    2015-01-01

    BACKGROUND: Tobacco smoking is more prevalent among the elderly than among the young, and the elderly also have the most frequent contact with the health care system. The aim of this study was to evaluate the effectiveness of the Gold Standard Program, which is an intensive six-week smoking...... cessation program, on continuous self-reported abstinence rates after six months, on participants over the age of 60 years in a real life setting. METHODS: This was a retrospective cohort study from the national Danish smoking cessation database. RESULTS: The database registered 7369 participants over...... recommendation for smoking cessation (OR 1.12), being compliant with program (OR 1.35) and being abstinent at end of course (OR 13.3). CONCLUSIONS: Participants over the age of 60 years had significantly higher continuous abstinence rates after six months than the participants less than 60 years. It is never too...

  6. Patient perspective on herpes zoster and its complications: an observational prospective study in patients aged over 50 years in general practice.

    Science.gov (United States)

    Bouhassira, Didier; Chassany, Olivier; Gaillat, Jacques; Hanslik, Thomas; Launay, Odile; Mann, Claude; Rabaud, Christian; Rogeaux, Olivier; Strady, Christophe

    2012-02-01

    Understanding the effect of herpes zoster and zoster-related pain should inform care to improve health-related quality of life in elderly patients. A 12-month, longitudinal, prospective, multicenter observational study conducted in primary care in France enrolled patients aged ≥ 50 years with acute eruptive herpes zoster. Patient-reported zoster-related pain was assessed by validated questionnaires (Douleur Neuropathique en 4 Questions [DN4], Zoster Brief Pain Inventory [ZBPI], and Neuropathic Pain Symptom Inventory [NPSI]) on days 0 and 15, and at months 1, 3, 6, 9, and 12. Health-related quality of life was assessed by the 12-item short-form health survey (SF-12) and the Hospital Anxiety and Depression scale on day 0 and at months 3, 6, and 12. Of 1358 patients included, 1032 completed follow-up. Mean ± standard deviation age was 67.7 ± 10.7 (range, 50-95) years; 62.2% were women. Most patients (94.1%) were prescribed antiviral drugs. The prevalence of zoster-related pain on day 0 and at months 3, 6, 9, and 12 was 79.6%, 11.6%, 8.5%, 7.4%, and 6.0%, respectively. Patients with persistent pain had lower scores on the physical and mental component summaries of the SF-12 and the ZBPI interference score than those without pain. By logistic regression analysis, main predictive factors on day 0 for postherpetic neuralgia at month 3 were age, male sex, ZBPI interference score, Physical Component Summary score of the SF-12, and neuropathic quality of pain (DN4 score ≥ 4). Despite early diagnosis and treatment with antiviral agents, many patients with herpes zoster experience persistent pain and marked long-term reduction in health-related quality of life.

  7. Association between comorbid conditions and BADL/IADL disability in hypertension patients over age 45: Based on the China health and retirement longitudinal study (CHARLS).

    Science.gov (United States)

    Qian, Jiahui; Ren, Xiaohui

    2016-08-01

    Hypertension usually coexists with other chronic conditions and can cause disability in relation to activities of daily living. We examined the association between the number and categories of comorbid conditions and disability affecting activities of daily living in hypertension patients.The data were collected from the 2013 follow-up survey of the China Health and Retirement Longitudinal Study (CHARLS), which contains information about chronic conditions and disability. Additionally, socio-demographic characteristics of 3754 hypertension patients aged 45 and older were included in this study. Comorbid conditions included dyslipidemia, stroke, and 12 other chronic conditions. Disability in relation to activities of daily living was assessed using the basic activities of daily living (BADL) and the instrumental activities of daily living (IADL) instruments. Differences in BADL/IADL disability among patients with different comorbid conditions were compared using the chi-square test, and the influence of chronic conditions and socio-demographic characteristics on BADL/IADL disability was analyzed using logistic models.Without considering the influence of specific chronic conditions on BADL/IADL, hypertension patients with additional comorbid conditions were more likely to suffer from BADL/IADL disability. When considering the effect of specific chronic conditions, the number of comorbid conditions did not significantly influence BADL/IADL disability. Dyslipidemia, chronic lung disease, stroke, memory-related diseases, and arthritis/rheumatism were associated with BADL disability. Chronic lung diseases, heart diseases, stroke, stomach/digestive system diseases, emotional/nervous/psychiatric problems, memory-related diseases, arthritis/rheumatism, and asthma were associated with IADL disability. Additionally, female, people with lower education level, people living in village, and people living in middle and western China were more likely suffer from BADL

  8. CERN celebrates science over and over again!

    CERN Multimedia

    Anaïs Schaeffer

    2013-01-01

    CERN is getting ready to open its doors for two days of science and entertainment, but the celebrations don’t stop here. From 9 October 2013, France’s Fête de la Science will take up the reins. With more than 1,000 events all over France on the theme “From the infinitely large to the infinitely small", one of them is bound to be taking place near you.   Part of the programme from the Fête de la science in 2013 in the Rhône-Alpes region. Download the full programme here. The nearest one to CERN will be in Divonne-les-Bains. Put Wednesday, 9 October in your diary, because CERN will be taking part! From 10.30 a.m., join the members of Divonnelectro, an association set up by a group of CERN retirees, for a visit to France's oldest hydroelectric factory. At 2.30 p.m., head to the Esplanade du Lac in Divonne-les-Bains, where members of the Université pour tous du Pays de Gex will be offering ...

  9. Investigation of sleep disturbance in chronic low back pain: an age- and gender-matched case-control study over a 7-night period.

    LENUS (Irish Health Repository)

    van de Water, Alexander T M

    2011-12-01

    Sleep disturbance is frequently reported by people with chronic low back pain (>12 weeks; CLBP), but few studies have comprehensively investigated sleep in this population. This study investigated differences in subjectively and objectively measured sleep patterns of people with CLBP, and compared this to age- and gender matched controls. Thirty-two consenting participants (n = 16 with CLBP, n = 16 matched controls), aged 24-65 years (43.8% male) underwent an interview regarding sleep influencing variables, completed the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Pittsburgh Sleep Diary, SF36-v2, Hospital Anxiety and Depression Scale, Oswestry Disability Index, Numerical Pain Rating Scales, and underwent seven consecutive nights of actigraphic measurement in the home environment. Compared to controls, people with CLBP had, on self-report measures, significantly poorer sleep quality [Pittsburgh Sleep Quality Index (range 0-21) mean (SD) 10.9 (4.2)], clinical insomnia [Insomnia Severity Index mean (range 0-28) 13.7 (7.6)], lower sleep efficiency, longer sleep onset latency, more time awake after sleep onset, and more awakenings during sleep (p < 0.05). However, no significant differences between groups were found on objective actigraphy (p > 0.05). The findings provide some evidence to support self-reported sleep assessment as an outcome measure in CLBP research, while further research is needed to determine the validity of objective sleep measurement in this population.

  10. Is the Golden Age of the Private Research University Over?

    Science.gov (United States)

    Ehrenberg, Ronald G.

    2013-01-01

    After receiving his PhD in 1970, the author has spent almost 30 years conducting research on the economics of higher education, chairing faculty budget committees at Cornell, serving as a Cornell vice president and then as a trustee of both Cornell and SUNY, and being associated with innumerable national commissions and higher education…

  11. Human neurologic function and the aging process.

    Science.gov (United States)

    Potvin, A R; Syndulko, K; Tourtellotte, W W; Lemmon, J A; Potvin, J H

    1980-01-01

    Sixty-one normal men whose ages ranged from 20 to 80 years were evaluated on two occasions by means of a comprehensive series of 128 instrumented tests of neurologic function. The tests measured cognition, vision, strength, steadiness, reactions, speed, coordination, fatigue, gait, station, sensations, and tasks of daily living. The reliability of each test measured was determined, and any measure found unreliable (r less than or equal to 0.41) was not further analyzed. Significant age-related linear decreases were found for almost all neurologic functions. The declines over the age span varied from less than 10 percent to more than 90 percent for different functions. For the upper extremities, the largest declines (greater than 50 percent) were in hand-force steadiness, speed of hand-arm movements, and vibration sense; for the lower extremities, the largest declines were in one-legged balance with eyes closed and in vibration sense. For 13 of 14 tests in which significant dominant body-side effects were found, larger re-testing 7-10 days later, the subjects improved their scores by more than 5 percent on only 17 tests, 9 of which concerned the activities of daily living. No significant differential learning effects were found across age groups. The results point to the importance of developing a data bank on age-based neurologic function so that therapeutic effects can be evaluated in terms of age- and sex-matched normal functioning.

  12. Development and validation of a risk score predicting substantial weight gain over 5 years in middle-aged European men and women.

    Directory of Open Access Journals (Sweden)

    Annika Steffen

    Full Text Available BACKGROUND: Identifying individuals at high risk of excess weight gain may help targeting prevention efforts at those at risk of various metabolic diseases associated with weight gain. Our aim was to develop a risk score to identify these individuals and validate it in an external population. METHODS: We used lifestyle and nutritional data from 53°758 individuals followed for a median of 5.4 years from six centers of the European Prospective Investigation into Cancer and Nutrition (EPIC to develop a risk score to predict substantial weight gain (SWG for the next 5 years (derivation sample. Assuming linear weight gain, SWG was defined as gaining ≥ 10% of baseline weight during follow-up. Proportional hazards models were used to identify significant predictors of SWG separately by EPIC center. Regression coefficients of predictors were pooled using random-effects meta-analysis. Pooled coefficients were used to assign weights to each predictor. The risk score was calculated as a linear combination of the predictors. External validity of the score was evaluated in nine other centers of the EPIC study (validation sample. RESULTS: Our final model included age, sex, baseline weight, level of education, baseline smoking, sports activity, alcohol use, and intake of six food groups. The model's discriminatory ability measured by the area under a receiver operating characteristic curve was 0.64 (95% CI = 0.63-0.65 in the derivation sample and 0.57 (95% CI = 0.56-0.58 in the validation sample, with variation between centers. Positive and negative predictive values for the optimal cut-off value of ≥ 200 points were 9% and 96%, respectively. CONCLUSION: The present risk score confidently excluded a large proportion of individuals from being at any appreciable risk to develop SWG within the next 5 years. Future studies, however, may attempt to further refine the positive prediction of the score.

  13. MAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formation.

    Science.gov (United States)

    Tang, Ngang Heok; Toda, Takashi

    2015-03-01

    Mis-regulation (e.g. overproduction) of the human Ndc80/Hec1 outer kinetochore protein has been associated with aneuploidy and tumourigenesis, but the genetic basis and underlying mechanisms of this phenomenon remain poorly understood. Recent studies have identified the ubiquitous Ndc80 internal loop as a protein-protein interaction platform. Binding partners include the Ska complex, the replication licensing factor Cdt1, the Dam1 complex, TACC-TOG microtubule-associated proteins (MAPs) and kinesin motors. We review the field and propose that the overproduction of Ndc80 may unfavourably absorb these interactors through the internal loop domain and lead to a change in the equilibrium of MAPs and motors in the cells. This sequestration will disrupt microtubule dynamics and the proper segregation of chromosomes in mitosis, leading to aneuploid formation. Further investigation of Ndc80 internal loop-MAPs interactions will bring new insights into their roles in kinetochore-microtubule attachment and tumourigenesis.

  14. Age- and gender-specific estimates of cumulative CT dose over 5 years using real radiation dose tracking data in children

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Eunsol; Goo, Hyun Woo; Lee, Jae-Yeong [University of Ulsan College of Medicine, Asan Medical Center, Department of Radiology and Research Institute of Radiology, Seoul (Korea, Republic of)

    2015-08-15

    It is necessary to develop a mechanism to estimate and analyze cumulative radiation risks from multiple CT exams in various clinical scenarios in children. To identify major contributors to high cumulative CT dose estimates using actual dose-length product values collected for 5 years in children. Between August 2006 and July 2011 we reviewed 26,937 CT exams in 13,803 children. Among them, we included 931 children (median age 3.5 years, age range 0 days-15 years; M:F = 533:398) who had 5,339 CT exams. Each child underwent at least three CT scans and had accessible radiation dose reports. Dose-length product values were automatically extracted from DICOM files and we used recently updated conversion factors for age, gender, anatomical region and tube voltage to estimate CT radiation dose. We tracked the calculated CT dose estimates to obtain a 5-year cumulative value for each child. The study population was divided into three groups according to the cumulative CT dose estimates: high, ≥30 mSv; moderate, 10-30 mSv; and low, <10 mSv. We reviewed clinical data and CT protocols to identify major contributors to high and moderate cumulative CT dose estimates. Median cumulative CT dose estimate was 5.4 mSv (range 0.5-71.1 mSv), and median number of CT scans was 4 (range 3-36). High cumulative CT dose estimates were most common in children with malignant tumors (57.9%, 11/19). High frequency of CT scans was attributed to high cumulative CT dose estimates in children with ventriculoperitoneal shunt (35 in 1 child) and malignant tumors (range 18-49). Moreover, high-dose CT protocols, such as multiphase abdomen CT (median 4.7 mSv) contributed to high cumulative CT dose estimates even in children with a low number of CT scans. Disease group, number of CT scans, and high-dose CT protocols are major contributors to higher cumulative CT dose estimates in children. (orig.)

  15. 44 CFR 80.5 - Roles and responsibilities.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Roles and responsibilities... ACQUISITION AND RELOCATION FOR OPEN SPACE General § 80.5 Roles and responsibilities. The roles and... this section. These are in addition to grants management roles and responsibilities identified...

  16. Pancreatic Cancer: 80 Years of Surgery—Percentage and Repetitions

    Directory of Open Access Journals (Sweden)

    Birgir Gudjonsson

    2016-01-01

    Full Text Available Objective. The incidence of pancreatic cancer is estimated to be 48,960 in 2015 in the US and projected to become the second and third leading causes of cancer-related deaths by 2030. The mean costs in 2015 may be assumed to be $79,800 per patient and for each resection $164,100. Attempt is made to evaluate the results over the last 80 years, the number of survivors, and the overall survival percentage. Methods. Altogether 1230 papers have been found which deal with resections and reveal survival information. Only 621 of these report 5-year survivors. Reservation about surgery was first expressed in 1964 and five-year survival of nonresected survivors is well documented. Results. The survival percentage depends not only on the number of survivors but also on the subset from which it is calculated. Since the 1980s the papers have mainly reported the number of resections and survival as actuarial percentages, with or without the actual number of survivors being reported. The actuarial percentage is on average 2.75 higher. Detailed information on the original group (TN, number of resections, and actual number of survivors is reported in only 10.6% of the papers. Repetition occurs when the patients from a certain year are reported several times from the same institution or include survivors from many institutions or countries. Each 5-year survivor may be reported several times. Conclusion. Assuming a 10% resection rate and correcting for repetitions and the life table percentage the overall actual survival rate is hardly more than 0.3%.

  17. Exercise and age

    Science.gov (United States)

    ... It is never too late to start exercising. Exercise has benefits at any age. Don't worry if you ... to tie your shoes Alternative Names Age and exercise Images Benefit of regular exercise Flexibility exercise Exercise and age ...

  18. C80H80几何结构和电子性质的密度泛函研究%Density functional study on the geometric and electronic properties of C80H80

    Institute of Scientific and Technical Information of China (English)

    曹青松; 袁勇波; 肖传云; 陆瑞锋; 阚二军; 邓开明

    2012-01-01

    The generalized gradient approximation based on the density functional theory is used to analyze the geometric and the electronic properties of C80H80. The geometric structure research indicates that between the two possible stable isomers, the isomer with 20 hydrogens connecting 12 pentagons and the 60 others outside is more stable structure. The analyses of the energy level, the orbital wavefunction, and the density of states of H20 @C80H60, show that the atomic orbits of the H and C atoms have strong hybridization on the occupied molecular orbits. The low unoccupied molecular orbital of H20@C80H60 is occupied mainly by the H atoms inside the carbon cage, while the high occupied molecular orbital of H20@C80H60 are occupied partly by the H atoms outside the cage. Therefore, the H atoms inside and outside the cage will play different roles in the chemical reaction involving H20@C80H60. TheH20@C80H60 shows the character of the closed-shell structures with no magnetic moment.%采用密度泛函理论方法中的广义梯度近似,对C80H80几何结构和电子性质进行了研究.几何结构研究表明:在C80H80可能稳定存在的两种同分异构体中,连接12个五边形的20个c原子内部氢化,其余60个C原子外部氢化所形成的结构即H20@C80H60最稳定,其仍然保持厶对称性.通过对H20@C80H60的能级、前线轨道和态密度分析可知:在H20@C80H60中,H原子的原子轨道与C原子的原子轨道之间在占据态轨道上有较强的杂化,H原子对H20@C80H60的占据态轨道的贡献比较大.其最高占据轨道主要由外部H原子和碳笼来贡献,而最低未占据轨道主要由内部H原子贡献,表明内外H原子在H20@C80H60的化学反应中承担不同的角色.H20@C80H60为闭壳层结构,所有电子都是配对的,表现为非磁性.

  19. 7 CFR 27.80 - Fees; classification, Micronaire, and supervision.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Fees; classification, Micronaire, and supervision. 27... Classification and Micronaire § 27.80 Fees; classification, Micronaire, and supervision. For services rendered by... classification and Micronaire determination results certified on cotton class certificates.) (e) Supervision,...

  20. Clinical features of the elderly patients over 80 years with cute cerebral infarction%老老年急性脑梗死患者的临床特征分析

    Institute of Scientific and Technical Information of China (English)

    凌莉; 李小强; 张素平; 尹义臣; 王慕真; 何锐; 邓婉青

    2015-01-01

    Objective To investigate the risk factors,severity and infarct site features and clinical characteristics of the elderly patients over 80 years with cute cerebral infarction.Methods One hundred and sixty-two patients with acute cerebral infarction in Red Cross Hospital of Guangzhou,The Forth Affiliated Hospital of Medical College of Jinan University from January 2012 to May 2015 were enrolled and randomly divided into the elderly patients (≥ 80 years old) and the middle aged patients (< 60 years old).The risk factors,national institutes of health stroke scale (NIHSS) scores and Oxfordshire community stroke project (OCSP) criteria were compared between the two groups.Results Coronary artery disease,atrial fibrillation and NIHSS in the elderly patients (25% (22/88),13.6% (12/88),7.74 ± 4.986) were significantly higher than those of the middle aged group (12.2% (9/47),4.1% (3/74),5.04± 4.305),and the differences were significant (x2 =4.281,4.393,t =-3.649;P< 0.05 or P< 0.001).The logistic regression analysis finally showed that smoking,hyperlipemia,NIHSS scores and gender(male) were the independent risk factors(OR=3.851,3.609,1.100 and 2.670;P<0.05).There were more LACI patients in the elderly group than he middle aged group ((40.9%,36/88) vs.(60.8%,45/74),x2 =6.369,P < 0.05).Conclusion Compare to the middle aged patients,occurrence of the elderly patients with acute cerebral infarction is more severe,and the clinical features and risk factors have its particularity.Secondary prevention strategy should be emphasized on the control of different risk factors based on the patients' age.%目的 探讨老老年(≥80岁)急性脑梗死的危险因素、严重程度和梗死部位的特征.方法 选取2012年1月至2015年3月在我院住院的急性脑梗死患者162例,根据年龄分为≥80岁老年组88例和中青年(<60岁)组74例.对其危险因素、入院时的美国国立卫生研究院脑卒中量表(NIHSS

  1. Cancer in Women over 50 Years of Age: A Focus on Smoking

    Energy Technology Data Exchange (ETDEWEB)

    Baccaro, Luiz Francisco, E-mail: luiz.baccaro@gmail.com [Department of Gynecology, State University of Campinas, Rua Alexander Fleming, 101, Cidade Universitária Zeferino Vaz, Campinas, São Paulo 13.083-881 (Brazil); Conde, Délio Marques [Breast Clinic, Hospital for Maternal and Child Healthcare, Goiânia, Goiás 74.125-120 (Brazil); Costa-Paiva, Lúcia; Machado, Vanessa de Souza Santos; Pinto-Neto, Aarão Mendes [Department of Gynecology, State University of Campinas, Campinas, São Paulo 13.083-881 (Brazil)

    2015-03-17

    The increase in life expectancy worldwide has resulted in a greater prevalence of chronic non-communicable diseases. This study aims to evaluate the prevalence and factors associated with the occurrence of cancer among Brazilian women over the age of 50. A cross-sectional study with 622 women over the age of 50 was performed using a population survey. The outcome variable was the occurrence of a malignant tumor in any location. The independent variables were sociodemographic characteristics, self-perception of health, health-related habits and morbidities. Statistical analysis was carried out using the chi-square test and Poisson regression. The mean age of the women was 64.1 years. The prevalence of cancer was 6.8%. The main sites of occurrence of malignant tumors were the breast (31.9%), colorectal (12.7%) and skin (12.7%). In the final statistical model, the only factor associated with cancer was smoking > 15 cigarettes/day either currently or in the past: PR 2.03 (95% CI 1.06–3.89). The results have improved understanding of the prevalence and factors associated with cancer in Brazilian women aged 50 years or more. They should be encouraged to maintain a healthy lifestyle and pay particular attention to modifiable risk factors such as smoking.

  2. Cancer in Women over 50 Years of Age: A Focus on Smoking

    Directory of Open Access Journals (Sweden)

    Luiz Francisco Baccaro

    2015-03-01

    Full Text Available The increase in life expectancy worldwide has resulted in a greater prevalence of chronic non-communicable diseases. This study aims to evaluate the prevalence and factors associated with the occurrence of cancer among Brazilian women over the age of 50. A cross-sectional study with 622 women over the age of 50 was performed using a population survey. The outcome variable was the occurrence of a malignant tumor in any location. The independent variables were sociodemographic characteristics, self-perception of health, health-related habits and morbidities. Statistical analysis was carried out using the chi-square test and Poisson regression. The mean age of the women was 64.1 years. The prevalence of cancer was 6.8%. The main sites of occurrence of malignant tumors were the breast (31.9%, colorectal (12.7% and skin (12.7%. In the final statistical model, the only factor associated with cancer was smoking > 15 cigarettes/day either currently or in the past: PR 2.03 (95% CI 1.06–3.89. The results have improved understanding of the prevalence and factors associated with cancer in Brazilian women aged 50 years or more. They should be encouraged to maintain a healthy lifestyle and pay particular attention to modifiable risk factors such as smoking.

  3. Cancer in Women over 50 Years of Age: A Focus on Smoking.

    Science.gov (United States)

    Baccaro, Luiz Francisco; Conde, Délio Marques; Costa-Paiva, Lúcia; de Souza Santos Machado, Vanessa; Pinto-Neto, Aarão Mendes

    2015-01-01

    The increase in life expectancy worldwide has resulted in a greater prevalence of chronic non-communicable diseases. This study aims to evaluate the prevalence and factors associated with the occurrence of cancer among Brazilian women over the age of 50. A cross-sectional study with 622 women over the age of 50 was performed using a population survey. The outcome variable was the occurrence of a malignant tumor in any location. The independent variables were sociodemographic characteristics, self-perception of health, health-related habits and morbidities. Statistical analysis was carried out using the chi-square test and Poisson regression. The mean age of the women was 64.1 years. The prevalence of cancer was 6.8%. The main sites of occurrence of malignant tumors were the breast (31.9%), colorectal (12.7%) and skin (12.7%). In the final statistical model, the only factor associated with cancer was smoking > 15 cigarettes/day either currently or in the past: PR 2.03 (95% CI 1.06-3.89). The results have improved understanding of the prevalence and factors associated with cancer in Brazilian women aged 50 years or more. They should be encouraged to maintain a healthy lifestyle and pay particular attention to modifiable risk factors such as smoking.

  4. Sense of coherence changes with aging over the second half of life.

    Science.gov (United States)

    Silverstein, Merril; Heap, Josephine

    2015-03-01

    Sense of coherence (SOC), a concept reflecting meaningfulness, comprehensibility, and manageability of life, has been demonstrated to have strong connections to positive outcomes such as good health. However, less is known about how SOC changes over the second half of life as age-related deficits accumulate. We used longitudinal samples of mature adults that included the oldest-old to track change in SOC from age 55 to 101. Growth curves using an accelerated longitudinal design were estimated for 1809 individuals who contributed 4072 observations from five national Swedish surveys between 1991 and 2010/11. Results indicated that deficits in health and social resources were largely responsible for the precipitous decline in SOC after age 70. When controlling for these deficits, SOC increased continuously into advanced old age. We conclude that the capacity to comprehend, manage, and find meaning in life--the component elements of SOC--strengthens over the last years of life, suggesting a positive ontogenic development that runs parallel but opposite to the negative impact of health and social decline.

  5. Worldwide cutaneous malignant melanoma incidences analyzed by sex, age, and skin type over time (1955–2007): Is HPV infection of androgenic hair follicular melanocytes a risk factor for developing melanoma exclusively in people of European-ancestry?

    Science.gov (United States)

    Merrill, Stephen J.; Subramanian, Madhan; Godar, Dianne E.

    2016-01-01

    ABSTRACT The cutaneous malignant melanoma (CMM) incidence has been increasing in an exponential manner in certain populations around the world for over 7 decades. To help illuminate the etiology, we performed worldwide temporal (1955–2007) CMM incidence analysis by sex, age (0–14, 15–29, 30–49, 50–69, 70–85+), and skin type on 6 continents using data from the International Agency for Research on Cancer. We observe an exponential increase in the CMM incidence over time and an increase of about 2 orders of magnitude between age groups 0–14 and 15–29 exclusively in European-ancestry populations around the world independent of skin type (I–III or III–IV). Other populations like the Chinese (III-IV) had much lower CMM incidences that either remained stable or temporally decreased but did not display a dramatic increase between the youngest age groups. The dramatic increase in the incidence between the youngest age groups found only in European-ancestry populations suggests one of the most important risk factors for CMM may be developing androgenic hair, the occurrence of which appears to correlate with the distribution of CMM over male and female body sites. Besides that potential new risk factor, the increasing CMM incidence with increasing age, known not to be from cumulative UV doses, may be associated with age-related changes to skin, i.e., thinning epidermis causing lower vitamin D3 levels, and hair, i.e., whitening from higher reactive oxygen species. The temporal exponential increasing CMM incidence in European-ancestry populations may be due to Human Papilloma Virus infection of follicular hair melanocytes, found in CMM biopsies. PMID:27588159

  6. 38 CFR 51.80 - Admission, transfer and discharge rights.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) PER DIEM FOR NURSING HOME CARE OF VETERANS IN STATE HOMES Standards § 51.80 Admission, transfer... resident and, if known, a family member or legal representative of the resident of the transfer or..., address and telephone number of the State long term care ombudsman. (7) Orientation for transfer...

  7. 21 CFR 129.80 - Processes and controls.

    Science.gov (United States)

    2010-04-01

    ... § 129.80 Processes and controls. (a) Treatment of product water. All treatment of product water by distillation, ion-exchanging, filtration, ultraviolet treatment, reverse osmosis, carbonation, mineral addition... bactericidal action. (4) 0.1 part per million ozone water solution in an enclosed system for at least 5...

  8. 40 CFR 80.84 - Treatment of interface and transmix.

    Science.gov (United States)

    2010-07-01

    ..., or gasoline or distillate fuel discharged from a safety relief valve. (f) Any transmix processor or... PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Reformulated Gasoline § 80.84 Treatment of...-identical petroleum product that consists of a mixture of the two adjacent products. (2) Transmix means...

  9. Clinical observation of therapeutic effects of endoscopic retrograde cholangiopancreatography in elderly patients over 80 years old with biliary-pancreatic diseases%逆行胰胆管造影治疗80岁以上老年人胆胰疾病的临床观察

    Institute of Scientific and Technical Information of China (English)

    王敏; 文卫; 缪林; 蒋国斌; 范志宁; 吴萍

    2009-01-01

    Objective To evaluate the efficacy and safety of endoscopic retrograde cholangiopancreatography (ERCP) in elderly patients over 80 years old with biliary-pancreatic diseases. Methods One hundred and twenty patients over 80 years old who underwent ERCP between January 2004 and April 2008 were retrospectively analyzed. The clinical efficacy, safety and complication were observed and followed up. Results One hundred and seventeen patients successfully underwent therapeutic ERCP and the success rate was 97.5%. All diseases of the patients included cholangiocarcinoma in 22 cases, duodenal papilla carcinoma in 3 cases, pancreatic carcinoma in 8 cases, acute pancreatitis in 15 cases, chronic pancreatitis in 5 cases, acute suppurative cholangitis in 9 cases and choledocholithiasis in 58 cases. During the procedure of ERCP, 3 cases failed to insert the duodenoscope, 3 cases were found hemobilia and 2 cases were found acute pancreatitis. Conclusions Therapeutic ERCP is effective and safe in elderly patients over 80 years. Age is not the contraindication of therapeutic ERCP.%目的 评价治疗性逆行胰胆管造影术(ERCP)对80岁以上老年患者胆胰疾病的疗效及安全性. 方法 回顾分析我院自2004年1月至2008年4月诊治的80岁以上行ERCP治疗的老年患者120例,同时观察其并发症. 结果 120例患者,造影成功117例(成功率97.5%),其中胆管癌22例,十二指肠乳头癌3例,胰腺癌8例,急性胆源性胰腺炎15例,慢性胰腺炎5例,急性化脓性胆管炎9例,胆总管结石58例.在ERCP过程中因血氧饱和度进行性下降和严重的心律失常而中止治疗2例;插镜失败1例,失败原因系肿瘤侵犯导致十二指肠球降部狭窄,镜身不能通过.胆道出血3例,急性胰腺炎2例. 结论 治疗性ERCP对80岁以上老年人胆胰疾病的诊治创伤小,且有效及安全,高龄并非治疗性ERCP的禁忌证.

  10. Aging and the intestine

    Institute of Scientific and Technical Information of China (English)

    Laurie Drozdowski; Alan BR Thomson

    2006-01-01

    Over the lifetime of the animal, there are many changes in the function of the body's organ systems. In the gastrointestinal tract there is a general modest decline in the function of the esophagus, stomach, colon,pancreas and liver. In the small intestine, there may be subtle alterations in the intestinal morphology, as well as a decline in the uptake of fatty acids and sugars.The malabsorption may be partially reversed by aging glucagon-like peptide 2 (GLP2) or dexamethasone.Modifications in the type of lipids in the diet will influence the intestinal absorption of nutrients: for example, in mature rats a diet enriched with saturated as compared with polysaturated fatty acids will enhance lipid and sugar uptake, whereas in older animals the opposite effect is observed. Thus, the results of studies of the intestinal adaptation performed in mature rats does not necessarily apply in older animals. The age-associated malabsorption of nutrients that occurs with aging may be one of the several factors which contribute to the malnutrition that occurs with aging.

  11. Late-Onset Hypogonadism in Male Patients Over 60 Years of Age with Metabolic Syndrome

    Directory of Open Access Journals (Sweden)

    Ekrem Kara

    2013-06-01

    Full Text Available Purpose: The aim of the study was to determine serum androgen levels and the frequency of late-onset hypogonadism (LOH in patients over 60 years of age with metabolic syndrome (MS and its correlation with parameters of MS. Material and Method: Men over 60 years of age who were diagnosed with MS according to the Adult Treatment Panel III (ATP III criteria in the internal medicine outpatient clinics at Cerrahpasa Medical School (n=30 and healthy controls (n=30 were included in the study. Total testosterone and sex hormone binding globulin (SHBG levels were analysed. Bioavailable and free testosterone levels were calculated. The participants filled up the Beck Depression Inventory (BDI and Aging Male Symptoms (AMS questionnaire forms themselves without any help of the physician. Results: LOH rates were 30% and 13.3% in the MS group and healthy control group, respectively (p=0.11. Serum total testosterone and SHBG levels were significantly lower in the MS group compared to controls (p=0.004 and p=0.003, respectively. A negative correlation was found between total testosterone and MS components. BDI and AMS questionnaire scores in the two groups were not significantly different.Discussion: Serum total testosterone and SHBG levels were lower in the MS group, and inversely proportional to this, insulin resistance and intensity of MS components were increased. Turk Jem 2013; 17: 22-7

  12. Respiratory distress syndrome in newborns of gestational age of over 32 weeks.

    Science.gov (United States)

    Rimar, Zeljka; Milas, Vesna; Medimurec, Maja; Mesić, Ivana

    2014-06-01

    Albeit the aetiology of the respiratory distress syndrome (RDS) is well known, the paper shall demonstrate that the causes of RDS changed over the years 2006 and 2010. This retrospective study comprises analysis of the data collected from 60 newborns of over 32 weeks gestation with RDS in the Neonatal Intensive Care Unit at the Clinical Hospital Centre in Osijek. The focus of the paper lies in the difference in the incidence of RDS over two research periods (2006 and 2010), the most common and possible causes of RDS in newborns of over 32 weeks gestation as well as in the potential changes in the aetiology over the two research periods. An increase in the incidence of RDS was established in 2010, but it was statistically significant only for newborns of gestational age of 35 1/7 to 36 6/7 weeks. The most common cause of RDS in both research periods was sepsis, which decreased in its share in 2010, whereas the incidence of asphyxia and complications during pregnancy increased. The new potential cause in 2010 was maternal thrombophilia. The share of unknown causes of RDS decreased, although not significantly so. The results of the research indicate that the causes of RDS changed over the observed periods and that further research should focus on thrombophilia and other complications during pregnancy with the aim of reducing morbidity and improving neonatal outcomes as well as further reducing the incidence of RDS with unknown causes in newborns.

  13. Exercise, Cognitive Function, and Aging

    Science.gov (United States)

    Barnes, Jill N.

    2015-01-01

    Increasing the lifespan of a population is often a marker of a country's success. With the percentage of the population over 65 yr of age expanding, managing the health and independence of this population is an ongoing concern. Advancing age is associated with a decrease in cognitive function that ultimately affects quality of life. Understanding…

  14. [EFFECT OF OVERWEIGHT AND OBESITY ON THE EQUILIBRIUM TIME, BUT NO IN THE TOTAL BODY WATER AND BODY COMPOSITION COMPARTMENTS IN WOMEN SUBJECTS OVER 60 YEARS OF AGE].

    Science.gov (United States)

    Lizárraga-Cañedo, Jonathan; Robles-Sardin, Alma; Salazar, Gabriela; Alemán-Mateo, Heliodoro

    2015-12-01

    Introducción: el envejecimiento y la obesidad producen cambios en la tasa de recambio de agua, lo que podría afectar al tiempo de equilibrio del óxido de deuterio (2H2O). Objetivo: se evaluó el efecto del sobrepeso y la obesidad sobre el tiempo de equilibrio del isótopo estable de deuterio en muestras de saliva de adultos mayores. Métodos: se incluyeron 18 mujeres entre 63 y 80 años con un índice de masa corporal (IMC) de 20,8 a 40,5 kg/m2. Después de la toma de una muestra de saliva basal se administró una dosis vía oral de 30 g de 2H2O. Se tomaron muestras de saliva a las 2, 2,5, 3, 3,5 y 4 horas post-dosis, las cuales fueron analizadas mediante espectrometría infrarroja con transformada de Fourier. Resultados: el tiempo de equilibrio (plateau) promedio en las mujeres con un IMC normal (18,5-24,9 kg/m2) fue de 3,6 ± 0,2 horas, el cual fue diferente estadísticamente al obtenido en el grupo con sobrepeso (25-29,9 kg/m2) y obesidad (>30 kg/m2) de 2,9 ± 0,4 horas y 2,8 ± 0,4 horas, respectivamente (p0,05). Conclusión: se encontró un efecto de la obesidad sobre el tiempo de equilibrio; sin embargo, no afectó al cálculo del agua corporal total y a la composición corporal en este grupo etario.

  15. Responses of female rock lizards to multiple scent marks of males: effects of male age, male density and scent over-marking.

    Science.gov (United States)

    Martín, José; López, Pilar

    2013-03-01

    Scent-marked substrates may inform conspecifics on the characteristics of territorial males. Scent-marks of male Carpetan rock lizards (Iberolacerta cyreni) affect space use of females, which by selecting an area may increase the probability of mating with the male that has scent-marked that area. However, males do not hold exclusive territories, and scent-marks of different individual males are often together. This may provide complex information from multiple sources on the social structure. Here, we examined female preference in response to scent marks of various males and combinations in a laboratory experiment. Females preferred areas scent-marked by territorial old males against those scent-marked by young satellite-sneaker males. This reflected the known preference of females for mating with old males. In a second experiment, females preferred areas scent-marked by two males to areas of similar size marked by a single male. This may increase the probability of obtaining multiple copulations with different males, which may favour sperm competition and cryptic female choice, or may be a way to avoid infertile males. Finally, when we experimentally over-marked the scent-marks of an old male with scent-marks of a young male, females did not avoid, nor prefer, the over-marked area, suggesting that the quality of the old male may override the presence of a satellite male. We suggest that, irrespective of the causes underlying why a female selects a scent-marked area, this strategy may affect her reproductive success, which may have the same evolutionary consequences that "direct" mate choice decisions of other animals.

  16. Natural and artefactual aneuploidy in human lymphocytes in extreme old age.

    Science.gov (United States)

    Lezhava, T; Khmaladze, E; Lokhadze, T; Buadze, T

    2008-04-01

    At present it is generally believed that aging is accompanied by an increase in the numbers of cells with altered chromosome sets. However, the problem of aneuploidy in extreme old age (80 years and over) has hardly been subjected to systematic investigation. The purpose of this study was to examine quantitative chromosome changes and relationship between "artefactual" and "natural" aneuploidy in subjects from 80 to 114 years of age using karyotype analyses. Chromosomes were studied in 1136 karyotypes of relatively round metaphases from 40 lymphocyte cultures obtained from 40 apparently normal subjects aged from 80 to 114 ( including 26 men and 14 women). 964 karyotypes from 48 donors aged 20 to 48 served as control. Lymphocytes were cultivation by modification method (Lezhava, 2006). It is suggested that the probability of natural aneuploidy rises substantially among elderly women; while that of artefactual aneuploidy is increased among elderly men; the problem of natural aneuploidy in males remains unclear.

  17. Family policy in France, 1960-80: achievements and prospects.

    Science.gov (United States)

    Boisard, P

    1983-01-01

    The destabilization of the family in France is, to some extent, attributable to the nation's adoption of inappropriate and inadequate family policies between 1960-80. Despite the family allowance program, the living standard of couples with children declined markedly since 1957. The program's defective benefit structure made it necessary for women with children to supplement family income by working. The high rate of female labor force participation contributed to the destabilization of the family. Evidence of destabilization includes: 1) the declining marriage rate, 2) the increasing number of women raising children by themselves, 3) the increasing divorce and illegitimate birth rates, and 4) the growing number of emotional problems among the young. The family assistance program was initiated in 1952. Until the early 1970s, surplus contributions to the program were continuously used to supplement other social programs, instead of being used to increase family assistance benefits. The program's single family allowance, designed to make it possible for families with children to live on income derived solely from husbands, provided such meager benefits that many women chose to work rather than to apply for the benefits. Consequently, the proportion of the family assistance budget allocated to the single family allowance declined from 43.7%-18.28% between 1952-72. In 1972, the single family allowance was increased, but then retained at the same level for the next 6 years. In 1978 the single family allowance benefit was abolished, and a family subsidy program, with a means test, was instituted. 58% of the beneficiaries of this program were single income families, 33% were multiple income families, and 9% were single parent families. At the present time benefits increase progressively as each new child is added. After 1977, Giscard d Estaing instituted a number of policies to assist large families. Unfortunately, other policies were instituted to promote abortion

  18. "One and the Same the World Over": The International Culture of Surgical Exchange in an Age of Globalization, 1870-1914.

    Science.gov (United States)

    Schlich, Thomas

    2016-07-01

    This paper examines the international exchange in surgery in the decades before World War I, a period of growing globalization in communication and transport. Focusing on Europe and North America, it looks first at the various means of exchange, especially surgical travel and the culture emerging around it and follows specific directions of exchange, from France and Britain, first to the German-speaking countries and finally to North America. Subsequently, the account turns to international organizations as an important means of exchange in this time period. The International Society of Surgery, in particular, provided a forum for a vivid internationalist discourse, which, however, stood in tension with simultaneous nationalist tendencies leading up to World War I. The paper finally discusses how the international exchange and communication at the time can be seen as an instance of modern surgeons claiming-and simultaneously trying to create-the global universality of surgical knowledge and practices, making sure that surgery is the same the world over.

  19. Reprogramming aging and progeria.

    Science.gov (United States)

    Freije, José M P; López-Otín, Carlos

    2012-12-01

    The aging rate of an organism depends on the ratio of tissue degeneration to tissue repair. As a consequence, molecular alterations that tip this balance toward degeneration cause accelerated aging. Conversely, interventions can be pursued to reduce tissue degeneration or to increase tissue repair with the aim of delaying the onset of age-associated manifestations. Recent studies on the biology of stem cells in aging have revealed the influence of systemic factors on their functionality and demonstrated the feasibility of reprogramming aged and progeroid cells. These results illustrate the reversibility of some aspects of the aging process and encourage the search for new anti-aging and anti-progeria interventions.

  20. UV, stress and aging

    OpenAIRE

    Debacq-Chainiaux, Florence; Leduc, Cedric; Verbeke, Alix; Toussaint, Olivier

    2014-01-01

    Skin is a model of choice in studies on aging. Indeed, skin aging can be modulated by internal and external factors, reflecting its complexity. Two types of skin aging have been identified: intrinsic, mainly genetically determined and extrinsic—also called "photo-aging"—resulting on the impact of environmental stress and more precisely of UV rays. Simplified in vitro models, based on cellular senescence, have been developed to study the relationship between UV and aging. These models vary on ...

  1. The rationale and design features for the 40 by 80/80 by 120 foot wind tunnel

    Science.gov (United States)

    Mort, K. W.; Kelly, M. W.; Hickey, D. H.

    1976-01-01

    A substantial increase in the test capability of full scale wind tunnels is considered. In order to determine the most cost effective means for providing this desired increase in test capability, a series of design studies were conducted of various new facilities as well as of major modifications to the existing 40- by 80-foot wind tunnel. The most effective trade between test capability and facility cost was provided by repowering the existing 40 by 80 foot wind tunnel to increase the maximum speed from 200 knots to 300 knots and by the addition of a new 80- by 120-foot test section having a 110 knot maximum speed. The design of the facility is described with special emphasis on the unique features, such as the drive system which absorbs nearly four times the power without an increase in noise, and the large flow diversion devices required to interface the two test sections to a single drive.

  2. Stem cells and healthy aging.

    Science.gov (United States)

    Goodell, Margaret A; Rando, Thomas A

    2015-12-04

    Research into stem cells and aging aims to understand how stem cells maintain tissue health, what mechanisms ultimately lead to decline in stem cell function with age, and how the regenerative capacity of somatic stem cells can be enhanced to promote healthy aging. Here, we explore the effects of aging on stem cells in different tissues. Recent research has focused on the ways that genetic mutations, epigenetic changes, and the extrinsic environmental milieu influence stem cell functionality over time. We describe each of these three factors, the ways in which they interact, and how these interactions decrease stem cell health over time. We are optimistic that a better understanding of these changes will uncover potential strategies to enhance stem cell function and increase tissue resiliency into old age.

  3. [Construction of age group vegetation index and preliminary application].

    Science.gov (United States)

    Xu, Zhang-hua; Li, Cong-hui; Liu, Jian; Yu, Kun-yong; Gong, Cong-hong; Tang, Meng-ya

    2014-06-01

    In the present paper, one remote sensing index-age group vegetation index (AGVI) was put forward, and its feasibility was verified. Taking 518 groups of pine forest age group data collected in 13 counties (cities) of Sanming, Jiangle, Shaxian, Nanping, Huaan, Yunxiao, Nanping, Anxi, Putian, Changting, Jianyang, Ningde and Fuqing, Fujian Province and HJ-1 CCD multi-spectral image at the same time-phase as the basis, the spectrum differences of blue, green, red, near infrared and NDVI of each age group were analyzed, showing the characteristics of young forest>middle-aged forest>over-mature forest>mature forest>near mature forest at near infrared band and mature forest>near mature forest>over-mature forest>young forest>middle-aged forest at NDVI, thus the age group vegetation index (AGVI) was constructed; the index could increase the absolute and relative spectrum differences among age groups. For the pine forest AGVI, cluster analysis was conducted with K-mean method, showing that the division accuracy of pine forest age group was 80.45%, and the accurate rate was 90.41%. Therefore, the effectiveness of age group vegetation index constructed was confirmed.

  4. Nutrients, Microglia Aging, and Brain Aging.

    Science.gov (United States)

    Wu, Zhou; Yu, Janchun; Zhu, Aiqin; Nakanishi, Hiroshi

    2016-01-01

    As the life expectancy continues to increase, the cognitive decline associated with Alzheimer's disease (AD) becomes a big major issue in the world. After cellular activation upon systemic inflammation, microglia, the resident immune cells in the brain, start to release proinflammatory mediators to trigger neuroinflammation. We have found that chronic systemic inflammatory challenges induce differential age-dependent microglial responses, which are in line with the impairment of learning and memory, even in middle-aged animals. We thus raise the concept of "microglia aging." This concept is based on the fact that microglia are the key contributor to the acceleration of cognitive decline, which is the major sign of brain aging. On the other hand, inflammation induces oxidative stress and DNA damage, which leads to the overproduction of reactive oxygen species by the numerous types of cells, including macrophages and microglia. Oxidative stress-damaged cells successively produce larger amounts of inflammatory mediators to promote microglia aging. Nutrients are necessary for maintaining general health, including the health of brain. The intake of antioxidant nutrients reduces both systemic inflammation and neuroinflammation and thus reduces cognitive decline during aging. We herein review our microglia aging concept and discuss systemic inflammation and microglia aging. We propose that a nutritional approach to controlling microglia aging will open a new window for healthy brain aging.

  5. Aging related changes in determinants of muscle force generating capacity: a comparison of muscle aging in men and male rodents.

    Science.gov (United States)

    Ballak, Sam B; Degens, Hans; de Haan, Arnold; Jaspers, Richard T

    2014-03-01

    Human aging is associated with a progressive decline in skeletal muscle mass and force generating capacity, however the exact mechanisms underlying these changes are not fully understood. Rodents models have often been used to enhance our understanding of mechanisms of age-related changes in human skeletal muscle. However, to what extent age-related alterations in determinants of muscle force generating capacity observed in rodents resemble those in humans has not been considered thoroughly. This review compares the effect of aging on muscle force generating determinants (muscle mass, fiber size, fiber number, fiber type distribution and muscle specific tension), in men and male rodents at similar relative age. It appears that muscle aging in male F344*BN rat resembles that in men most; 32-35-month-old rats exhibit similar signs of muscle weakness to those of 70-80-yr-old men, and the decline in 36-38-month-old rats is similar to that in men aged over 80 yrs. For male C57BL/6 mice, age-related decline in muscle force generating capacity seems to occur only at higher relative age than in men. We conclude that the effects on determinants of muscle force differ between species as well as within species, but qualitatively show the same pattern as that observed in men.

  6. 球囊扩张联合神经肌肉电刺激治疗80岁以上高龄脑卒中后吞咽障碍的临床观察%Bal oon expansion joint neuromuscular electrical stimulation treatment on over 80 - year - old swal owing disorder after stroke clinical observation

    Institute of Scientific and Technical Information of China (English)

    许海生; 刘捷; 张锋伟; 贾炜

    2014-01-01

    Objective observation of bal oon dilatation joint neuromuscular electrical stimulation to the curative effect of senile patients with swal owing disorder after stroke, and safety. Method by TV fluoroscopy swal ow function (VFSS), after the bal oon expansion and real-time neuromuscular electrical stimulator (VitalStim) treatment old age (> 80 years) patients with swal owing disorder after stroke (3 cases), once a day, the course of 8 ~ 12 days. Results after treatment, patients with bal oon expansion volume increased by 4 ~ 5 ml to 8 ~8.5 ml, VFSS, barium residue in the val ey of epiglottis, piriform fossa decreased significantly, without choking cough or aspiration, ring open basic normal pharyngeal muscles, food can be smoothly through ring pharyngeal muscle into the esophagus, patients can safely through the mouth to eat. Conclusion preliminary showed that bal oon expansion for over 80 - year - old patients with swal owing disorder treatment is effective and safe.%目的:观察球囊扩张术联合神经肌肉电刺激对高龄患者卒中后吞咽障碍的疗效及安全性。方法经电视透视吞咽功能检查(VFSS)后,采用球囊扩张并实时神经肌肉电刺激仪(VitalStim)治疗高龄患者(>80岁)卒中后吞咽障碍3例,每天一次,疗程8~12天。结果治疗后患者球囊扩张量由4~5ml增加到8~8.5m l,VFSS显示,钡剂在会厌谷、梨状隐窝的残留量明显减少,无呛咳或误吸,环咽肌开放基本正常,食物可顺利通过环咽肌进入食道,患者可经口安全进食。结论初步表明球囊扩张对于80岁以上高龄患者吞咽障碍的治疗是有效且安全的。

  7. Microstructure evolution and effect on mechanical property in AZ80 Mg alloy during thermal processing

    Institute of Scientific and Technical Information of China (English)

    WANG Qiang; ZHANG Zhi-min; LI Bao-cheng; LI Xu-bin

    2006-01-01

    The microstructure and mechanical properties of AZ80 alloy were investigated during thermal processing. The samples of 4 mm in thickness machined from cast ingot were compressed at 300 ℃ with a thickness reduction of 75% and cooled in the water to room temperature. Then ageing(T5) and solution+ageing (T6) treatments were employed respectively. The results show that mechanical properties are significantly improved after thermal processing than those of as-cast AZ80 alloy due to grain refinement and discontinuous precipitates. The heat treatment has significant influence on microstructural evolution for sample formed at moderate temperature. Microstructural evaluation indicates that the β-phase increases because of sufficient solution and the alloy is strengthened evidently.

  8. [Age(ing), ambivalence and mimicry].

    Science.gov (United States)

    Küpper, Thomas

    2016-01-01

    This essay aims to show that the concept of ambivalence could prove especially productive for gerontology. It is known that age(ing) is a category that is characterized by difference and at the same time delineates a process. Ambivalence is eminently suitable for capturing this duality as it enables us to take into account the dynamics peculiar to age(ing) and move beyond those conventional rigid distinctions which fail to grasp key nuances. These theoretical considerations will be put to the test by looking at the so-called young-old and their ambivalent positioning as well as their own mimicry of the middle-agers.

  9. Successful Aging: Multiple Trajectories and Population Heterogeneity

    OpenAIRE

    Fengyan Tang

    2014-01-01

    Following Rowe and Kahn¡¯s successful aging model, this study identified successful aging as a distinctive aging trajectory and examined gender differences in the aging process. Using the Health and Retirement Study data (2000-2008), this study applied group-based trajectory analysis to identify multiple aging trajectories in a sample of older Americans aged 65 and over (N=9,226). Six dimensions were analyzed in the multi-trajectory model: chronic disease, physical functional limitation, disa...

  10. [Aging and gynecologic cancer].

    Science.gov (United States)

    Arrighi, Arturo A

    2005-01-01

    The interrelation between cancer and ageing in women is emphasized, on its increased incidence, in their molecular background, into the particular biological characteristics of the different tumors and the effects of ageing in the affected women.

  11. Precipitation behavior and effect of new precipitated β phase in AZ80 magnesium alloy

    Institute of Scientific and Technical Information of China (English)

    TANG Wei; HAN En-hou; XU Yong-bo; LIU Lu

    2006-01-01

    Granular precipitate that was a new kind of β-Mg17Al12 phase found in aged AZ80 wrought Mg alloy at all aging temperature was studied. The structure and precipitation behavior of this granular β-Mg17Al12 precipitate were studied by environmental scanning electron microscopy (ESEM) and transmission electron microscopy (TEM). The effect of the granular precipitate on mechanical properties of AZ80 alloy was also studied. The new precipitate that was granular and nucleated both on grain boundaries (GBs) and twin boundaries, has the same crystal structure and lattice parameter as those of the continuous or discontinuous precipitated β-Mg17Al12. And the nucleation and growth of the granular precipitate are faster than those of the other two precipitates at higher temperatures (above 583 K), but are suppressed at lower temperatures (below 423 K). At lower temperatures, the discontinuous β-Mg17Al12 precipitates firstly and the granular β-Mg17Al12 precipitates after aged more than 40 h. The crack is easily nucleated on the phase boundaries of granular phase and matrix because of the weak binding force. As a result, the strength and ductility of AZ80 Mg alloy are decreased by the granular β-Mg17Al12 precipitate.

  12. Striatal dopamine release induced by repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex: effect of aging

    Energy Technology Data Exchange (ETDEWEB)

    Bang, Seong Ae; Cho, Sang Soo; Yoon, Eun Jin; Kim, Ji Sun; Lee, Byung Chul; Kim, Yu Kyeong; Kim, Sang Eun [Seoul National Univ. College of Medicine, Seoul (Korea, Republic of)

    2007-07-01

    We previously demonstrated dopamine (DA) release in the bilateral striatal regions following prefrontal repetitive transcranial magnetic stimulation (rTMS) in young subjects. Several lines of evidence support substantial age-related changes in human dopaminergic neurotransmission. One possible explanation is alteration of cortico striatal neural connection with aging. Therefore, we investigated how frontal activation by rTMS influences striatal DA release in the elderly with SPECT measurements of striatal binding of [123I]iodobenzamide (lBZM), a DA D2 receptor radioligand that is sensitive to endogenous DA. Five healthy elderly male subjects (age, 64 3 y) were studied with brain [123I]IBZM SPECT under three conditions (resting, sham stimulation, and active rTMS over left dorsolateral prefrontal cortex (DLPFC)), while receiving a bolus plus constant infusion of [123I]IBZM. rTMS session consisted of three blocks. In each block, 15 trains of 2 sec duration were delivered with 10 Hz stimulation frequency and 100% motor threshold. Striatal V3', calculated as (striatal - occipital)/occipital radioactivity, was measured under equilibrium condition at baseline and after sham and active rTMS. Sham stimulation did not affect striatal V3'. rTMS over left DLPFC induced no significant change in V3' in the right striatum compared with baseline condition (0.91 0.25 vs. 0.96 0.25, P = NS). Interestingly, left striatal V3' showed a significant increase after rTMS over left DLPFC compared with sham condition (1.09 0.33 vs. 0.93 0.27, P < 0.05; 17.0 11.1% increase). These results are discrepant from previous ones from young subjects, who showed frontal rTMS-induced reduction of striatal V3', indicating rTMS-induced striatal DA release. We found no significant striatal DA release induced by rTMS over DLPFC in healthy elderly subjects using in vivo binding competition techniques. These results may support an altered cortico striatal circuit in normal aging.

  13. Optimal Aging and Death

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan; Strulik, Holger

    the representative consumer is subject to physiological aging. In modeling aging we draw on recent research in the fields of biology and medicine. The speed of the aging process, and thus the time of death, are endogenously determined by optimal health investments. We calibrate the model to US data and proceed...

  14. Skin Care and Aging

    Science.gov (United States)

    ... version of this page please turn Javascript on. Skin Care and Aging How Aging Affects Skin Your skin changes with age. It becomes thinner, ... to make it feel and look better. Dry Skin and Itching Click for more information Many older ...

  15. Polyphenols and Aging

    OpenAIRE

    Queen, Brannon L.; Tollefsbol, Trygve O.

    2010-01-01

    Age-associated changes within an individual are inherently complex and occur at multiple levels of organismal function. The overall decline in function of various tissues is known to play a key role in both aging and the complex etiology of certain age-associated diseases such as Alzheimer’s disease (AD) and cancer. Continuing research highlights the dynamic capacity of polyphenols to protect against age-associated disorders through a variety of important mechanisms. Numerous lines of evidenc...

  16. Development and Validation of a Risk Score Predicting Substantial Weight Gain over 5 Years in Middle-Aged European Men and Women

    DEFF Research Database (Denmark)

    Steffen, Annika; Sørensen, Thorkild; Knüppel, Sven;

    2013-01-01

    Identifying individuals at high risk of excess weight gain may help targeting prevention efforts at those at risk of various metabolic diseases associated with weight gain. Our aim was to develop a risk score to identify these individuals and validate it in an external population....

  17. Aging and Health: Cataracts

    Science.gov (United States)

    ... Problems Glaucoma Macular Degeneration Join our e-newsletter! Aging & Health A to Z Cataracts Basic Facts & Information ... Are Cataracts? Cataracts are a common result of aging and occur frequently in older people. About one ...

  18. Reasons for playing casual video games and perceived benefits among adults 18 to 80 years old.

    Science.gov (United States)

    Whitbourne, Susan Krauss; Ellenberg, Stacy; Akimoto, Kyoko

    2013-12-01

    Casual video games (CVGs) are becoming increasingly popular among middle-aged and older adults, yet there are few studies documenting why adults of different ages play these games, what benefits they perceive, and how regularly they play. The present study compared the online survey responses of 10,308 adults ranging from 18 to 80 years of age to questions regarding PopCap's popular free online game, Bejeweled Blitz (BJB). All respondents cited playing against friends as their main reason for playing. However, there were differences by age in the second most frequently cited reason. Middle-aged adults cited stress relief, and older adults reported that they seek the game's challenges. As a result of playing CVGs, younger adults noted that they felt sharper and experienced improved memory; older adults were more likely to feel that their visuospatial skills and response time benefited. Adults aged 60 and older had heavier patterns of game play than did adults under the age of 60 years. A significant number of respondents (14.7%) spontaneously noted that they felt that BJB had addictive qualities. CVG players seem to be drawn into this activity by its social nature and to a certain extent by its reinforcing properties. Once involved, however, they believe that they derive a number of benefits that, for older adults, appear to offset declines in age-sensitive cognitive functions.

  19. Real-world variability in ranibizumab treatment and associated clinical, quality of life, and safety outcomes over 24 months in patients with neovascular age-related macular degeneration: the HELIOS study

    Directory of Open Access Journals (Sweden)

    Rakic JM

    2013-09-01

    Full Text Available Jean-Marie Rakic,1 Anita Leys,2 Heidi Brié,3 Kris Denhaerynck,4 Christy Pacheco,4 Stefaan Vancayzeele,3 Christine Hermans,3 Karen MacDonald,4 Ivo Abraham4,5 1Department of Ophthalmology, Centre Hospitalier Universitaire de Liège, Site du Sart Tilman, Liège, Belgium; 2Leuven University Eye Hospital, Leuven, Belgium; 3Novartis Pharma, Vilvoorde, Belgium; 4Matrix45, Tucson, AZ, USA; 5Center for Health Outcomes and Pharmacoeconomic Research, University of Arizona, Tucson, AZ, USA Introduction: The aim of this study was to examine ranibizumab treatment patterns in "real-world" practice and clinical settings, as well as to assess quality of life outcomes over a 24-month period. Materials and methods: This was a prospective, observational, multicenter, open-label study of 0.5 mg of ranibizumab administered intravitreally. Patients were followed over 24 ± 3 months with intermediate data points at 6 ± 2 months and 12 ± 2 months, and a limited data point at 2.5 ± 1 month that coincided with the end of the loading phase. Outcomes included visual acuity (Early Treatment Diabetic Retinopathy Study, visual function (National Eye Institute Visual Function Questionnaire-25 [NEI VFQ-25], quality of life (Health Utilities Index Mark III [HUI3], and safety. Results: A total of 267 patients with wet age-related macular degeneration (mean ± standard deviation [SD] age = 78.5 ± 7.3 years; 62.4% were female; 34.5% with dual eye involvement; 74.9% were treatment-naïve were treated (309 eyes were treated. The mean ± SD Early Treatment Diabetic Retinopathy Study score at baseline was 56.3 ± 14.3 letters. The mean ± SD number of injections over 24 months was 7.6 ± 4.1, including 2.5 ± 0.7 and 5.9 ± 3.6 during the loading and maintenance phases, respectively, with corresponding treatment intervals of 4.8 ± 1.4 weeks and 11.5 ± 9.5 weeks, respectively. Improvements in visual acuity over baseline were reached at 2.5 months and maintained at 6 months (both P

  20. Language and Aging.

    Science.gov (United States)

    Kemper, Susan; Anagnopoulos, Cheryl

    1989-01-01

    Reviews the effects of aging on language usage focusing on three areas of exploration: (1) changes in language in relation to changes in other cognitive abilities, (2) the linguistic consequences of normal aging versus those of dementia and aphasia, and (3) age-group differences in patterns of conversational interaction. (67 references) (GLR)

  1. Thermodynamic structure of the marine atmosphere over the region 80-87°E along 13°N during August (phase II) BOBMEX-99

    Indian Academy of Sciences (India)

    Savita B Morwal; P Seetaramayya

    2003-06-01

    Thermodynamic structure of the marine atmosphere in the region between 80 and 87°E along 13°N over the Bay of Bengal was studied using 13 high resolution radiosonde profiles from surface −400 hPa collected onboard ORV Sagar Kanya during the period 27th-30th August, during BOBMEX-99. Saturation point concept, mixing line analysis and conserved variable diagrams have been used to identify boundary layer characteristics such as air mass movement and stability of the atmosphere. The results showed relatively dry air near the ocean surface between 1000 and 950 hPa. This feature is confirmed by the conserved v structure in this layer. Further, v seldom showed any inversions in this region. The e and es profiles showed persistent low cloud layers between 900 and 700 hPa. The conserved variable diagrams (e-q) showed the existence of double mixing line structures approximately at 950 and 700 hPa levels.

  2. Social, environmental and psychological factors associated with objective physical activity levels in the over 65s.

    Directory of Open Access Journals (Sweden)

    Marion E T McMurdo

    Full Text Available OBJECTIVE: To assess physical activity levels objectively using accelerometers in community dwelling over 65 s and to examine associations with health, social, environmental and psychological factors. DESIGN: Cross sectional survey. SETTING: 17 general practices in Scotland, United Kingdom. PARTICIPANTS: Random sampling of over 65 s registered with the practices in four strata young-old (65-80 years, old-old (over 80 years, more affluent and less affluent groups. MAIN OUTCOME MEASURES: Accelerometry counts of activity per day. Associations between activity and Theory of Planned Behaviour variables, the physical environment, health, wellbeing and demographic variables were examined with multiple regression analysis and multilevel modelling. RESULTS: 547 older people (mean (SD age 79(8 years, 54% female were analysed representing 94% of those surveyed. Accelerometry counts were highest in the affluent younger group, followed by the deprived younger group, with lowest levels in the deprived over 80 s group. Multiple regression analysis showed that lower age, higher perceived behavioural control, the physical function subscale of SF-36, and having someone nearby to turn to were all independently associated with higher physical activity levels (R(2 = 0.32. In addition, hours of sunshine were independently significantly associated with greater physical activity in a multilevel model. CONCLUSIONS: Other than age and hours of sunlight, the variables identified are modifiable, and provide a strong basis for the future development of novel multidimensional interventions aimed at increasing activity participation in later life.

  3. Emotional experience improves with age: evidence based on over 10 years of experience sampling.

    Science.gov (United States)

    Carstensen, Laura L; Turan, Bulent; Scheibe, Susanne; Ram, Nilam; Ersner-Hershfield, Hal; Samanez-Larkin, Gregory R; Brooks, Kathryn P; Nesselroade, John R

    2011-03-01

    Recent evidence suggests that emotional well-being improves from early adulthood to old age. This study used experience-sampling to examine the developmental course of emotional experience in a representative sample of adults spanning early to very late adulthood. Participants (N = 184, Wave 1; N = 191, Wave 2; N = 178, Wave 3) reported their emotional states at five randomly selected times each day for a one week period. Using a measurement burst design, the one-week sampling procedure was repeated five and then ten years later. Cross-sectional and growth curve analyses indicate that aging is associated with more positive overall emotional well-being, with greater emotional stability and with more complexity (as evidenced by greater co-occurrence of positive and negative emotions). These findings remained robust after accounting for other variables that may be related to emotional experience (personality, verbal fluency, physical health, and demographic variables). Finally, emotional experience predicted mortality; controlling for age, sex, and ethnicity, individuals who experienced relatively more positive than negative emotions in everyday life were more likely to have survived over a 13 year period. Findings are discussed in the theoretical context of socioemotional selectivity theory.

  4. Social resources and cognitive ageing across 30 years

    DEFF Research Database (Denmark)

    Gow, Alan J.; Mortensen, Erik Lykke

    2016-01-01

    Background: to examine associations between social resources and cognitive ageing over 30 years. Methods: participants in the Glostrup 1914 Cohort, a year of birth sample, completed a standardarised battery of cognitive ability tests every 10 years from age 50 to 80, summarised as general cognitive...... ability. Participants also provided information concerning a range of social resources, including marital status and living arrangements from age 50, and from age 70, details regarding social support, social contact and loneliness. Results: across the follow-up, participants were less likely to be married...... together (and accounting for sex, education and social class), loneliness was associated with lower cognitive ability level and greater cognitive decline, while married individuals experienced less decline. Conclusions: in a relatively large cohort followed for up to 30 years, marital status and loneliness...

  5. Aging, longevity and health.

    Science.gov (United States)

    Rasmussen, Lene Juel; Sander, Miriam; Wewer, Ulla M; Bohr, Vilhelm A

    2011-10-01

    The IARU Congress on Aging, Longevity and Health, held on 5-7 October 2010 in Copenhagen, Denmark, was hosted by Rector Ralf Hemmingsen, University of Copenhagen and Dean Ulla Wewer, Faculty of Health Sciences, University of Copenhagen and was organized by Center for Healthy Aging (CEHA) under the leadership of CEHA Managing Director Lene Juel Rasmussen and Prof. Vilhelm Bohr, National Institute on Aging, NIH, Baltimore, USA (associated to CEHA). The Congress was attended by approximately 125 researchers interested in and/or conducting research on aging and aging-related topics. The opening Congress Session included speeches by Ralf Hemmingsen, Ulla Wewer, and Lene Juel Rasmussen and Keynote Addresses by four world renowned aging researchers: Povl Riis (The Age Forum), Bernard Jeune (University of Southern Denmark), George Martin (University of Washington, USA) and Jan Vijg (Albert Einstein School of Medicine, USA) as well as a lecture discussing the art-science interface by Thomas Söderqvist (Director, Medical Museion, University of Copenhagen). The topics of the first six Sessions of the Congress were: Neuroscience and DNA damage, Aging and Stress, Life Course, Environmental Factors and Neuroscience, Muscle and Life Span and Life Span and Mechanisms. Two additional Sessions highlighted ongoing research in the recently established Center for Healthy Aging at the University of Copenhagen. This report highlights outcomes of recent research on aging-related topics, as described at the IARU Congress on Aging, Longevity and Health.

  6. Risk factors for urinary incontinence in Taiwanese women aged 60 or over.

    Science.gov (United States)

    Hsieh, Ching-Hung; Hsu, Chun-Sen; Su, Tsung-Hsien; Chang, Shao-Tung; Lee, Meng-Chih

    2007-11-01

    To determine risk factors of urinary incontinence (UI) in Taiwanese women aged 60 or over, face-to-face interviews with 1,517 women, selected by a multistage random method, were completed. The prevalence of UI in this age group was 29.8%. Factors and their prevalence associated with UI were age [odds ratio (OR)=1.04 per year], diabetes mellitus (39.8%, p = 0.002), hypertension (39.5%, p = 0.001), abdominal gynecological surgery (41.4%, p = 0.001), hysterectomy (42.4%, p = 0.003), history of drug allergy (41.3%, p = 0.001), smoking (45.5%, p = 0.010), hormone replacement therapy (41.5%, p = 0.026), and high body mass index (OR = 1.05 per unit). Alcohol consumption and marriage did not increase the risk of UI. UI is a common and costly problem in elderly women. It diminishes the quality of life of the affected women. Of the associated factors that are preventable, modifiable, or controllable, smoking, prior hysterectomy, and obesity may have the greatest impact on the prevalence of UI.

  7. Preparation for Old Age in Different Life Domains: Dimensions and Age Differences

    Science.gov (United States)

    Kornadt, Anna E.; Rothermund, Klaus

    2014-01-01

    We investigated preparation for age-related changes from a multidimensional, life span perspective and administered a newly developed questionnaire to a large sample aged 30-80 years. Preparing for age-related changes was organized by life domains, with domain-specific types of preparation addressing obstacles and opportunities in the respective…

  8. UV, stress and aging.

    Science.gov (United States)

    Debacq-Chainiaux, Florence; Leduc, Cedric; Verbeke, Alix; Toussaint, Olivier

    2012-07-01

    Skin is a model of choice in studies on aging. Indeed, skin aging can be modulated by internal and external factors, reflecting its complexity. Two types of skin aging have been identified: intrinsic, mainly genetically determined and extrinsic-also called "photo-aging"-resulting on the impact of environmental stress and more precisely of UV rays. Simplified in vitro models, based on cellular senescence, have been developed to study the relationship between UV and aging. These models vary on the cell type (fibroblasts or keratinocytes, normal or immortalized) and the type of UV used (UVA or UVB).

  9. Optimal Aging and Death

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan Lars; Strulik, Holger

    2010-01-01

    This study introduces physiological aging into a simple model of optimal intertemporal consumption. In this endeavor we draw on the natural science literature on aging. According to the purposed theory, the speed of the aging process and the time of death are endogenously determined by optimal...

  10. Variability in heart rate recovery measurements over 1 year in healthy, middle-aged adults.

    Science.gov (United States)

    Mellis, M G; Ingle, L; Carroll, S

    2014-02-01

    This study assessed the longer-term (12-month) variability in post-exercise heart rate recovery following a submaximal exercise test. Longitudinal data was analysed for 97 healthy middle-aged adults (74 male, 23 female) from 2 occasions, 12 months apart. Participants were retrospectively selected if they had stable physical activity habits, submaximal treadmill fitness and anthropometric measurements between the 2 assessment visits. A submaximal Bruce treadmill test was performed to at least 85% age-predicted maximum heart rate. Absolute heart rate and Δ heart rate recovery (change from peak exercise heart rate) were recorded for 1 and 2 min post-exercise in an immediate supine position. Heart rate recovery at both time-points was shown to be reliable with intra-class correlation coefficient values ≥ 0.714. Absolute heart rate 1-min post-exercise showed the strongest agreement between repeat tests (r = 0.867, P rate values rather than Δ heart rate recovery, and for 1-min rather than 2-min post-exercise recovery time points. Log-transformed values generated better variability with acceptable coefficient of variation for all measures (2.2-10%). Overall, 1 min post-exercise heart rate recovery data had least variability over the 12-month period in apparently healthy middle-aged adults.

  11. Signature splitting inversion and backbending in 80Rb

    CERN Document Server

    He, Chuangye; Wen, Shuxian; Zhu, Lihua; Wu, Xiaoguang; Li, Guangsheng; Zhao, Yue; Yan, Yupeng; Bai, Zhijun; Wu, Yican; Li, Yazhou; Li, Gui; Yan, Shiwei; Oshima, M; Toh, Y; Osa, A; Koizumi, M; Hatsukawa, Y; Matsuda, M; Hagakawa, T

    2012-01-01

    High spin states of 80Rb are studied via the fusion-evaporation reactions 65Cu+19F, 66Zn+18O and 68Zn+16O with the beam energies of 75 MeV, 76 MeV and 80 MeV, respectively. Twenty-three new states with twenty-eight new \\gamma transitions were added to the previously proposed level scheme, where the second negative-parity band is significantly pushed up to spins of 22^{-} and 15^{-} and two new sidebands are built on the known first negative-parity band. Two successive band crossings with frequencies 0.51 MeV and 0.61 MeV in the \\alpha=0 branch as well as another one in the \\alpha=1 branch of the second negative-parity band are observed for the first time. Signature inversions occur in the positive- and first negative-parity bands at the spins of 11\\hbar and 15\\hbar, respectively. The signature splitting is seen obviously in the second negative-parity band, but the signature inversion is not observed. It is also found that the structure of the two negative-parity bands is similar to that of its isotone ^{82}Y....

  12. Risk factors associated with postpartum hemorrhage among uniparas aged over 35 years from one grade 3 and first-class obstetrics and gynecology hospital of Beijing%北京市某三级甲等妇产专科医院高龄初产妇产后出血的影响因素分析

    Institute of Scientific and Technical Information of China (English)

    张红卫; 郭利; 张力亚

    2013-01-01

    目的 了解高龄初产妇产后出血的发生率及其危险因素.方法 对北京妇产医院2011年6月至2012年5月住院分娩的1 065例高龄产妇的住院病例资料进行回顾性分析,采用多因素Logistic回归模型分析高龄初产妇产后出血的危险因素.结果 高龄初产妇产后出血的发生率为15.02%.多因素Logistic回归分析显示以下因素与高龄初产妇的产后出血有关:宫缩乏力(AOR>999.999)、前置胎盘(AOR:24.72;95% CI:4.82~126.80)、试管婴儿(AOR:5.79;95% CI:1.50~22.31)、足月产(AOR:0.26;95% CI:0.07~0.96).结论 高龄初产妇是产后出血的高危人群,确认危险因素,加强宣教,及早治疗有助于降低产妇的产后出血率及死亡率.%Objective To determine the incidence and risk factors of postpartum hemorrhage among uniparas aged 35 years or older.Methods This hospital-based study included 1 065 advanced maternal age between June 2011 and May 2012 from Beijing Obstetrics and Gynecology Hospital.A multiple logistic model was used to identify risk factors independently associated postpartum hemorrhage among the pregnancy women aged over 35 years.Results The incidence of postpartum hemorrhage was 15%.Multiple Logistic analysis results showed that uterine atony (AOR >999.999),placenta previa (AOR:24.72 ;95% CI:4.82-126.80),test-tube baby (AOR:5.79 ; 95 % CI:1.50-22.31),and term infants (AOR:0.26 ; 95 % CI:0.07-0.96)were the risk factors for uniparas aged over 35 years.Conclusions Uniparas aged over 35 years are high-risk groups for postpartum hemorrhage.So doctors and nurses should identify the risk factors for postpartum hemorrhage of uniparas aged over 35 years,emphasize health education and provide early treatment so that the rote of postpartum hemorrhage and the mortality of pregnancy women can be reduced.

  13. Ageing and neurodegenerative diseases.

    Science.gov (United States)

    Hung, Chia-Wei; Chen, Yu-Chih; Hsieh, Wan-Ling; Chiou, Shih-Hwa; Kao, Chung-Lan

    2010-11-01

    Ageing, which all creatures must encounter, is a challenge to every living organism. In the human body, it is estimated that cell division and metabolism occurs exuberantly until about 25 years of age. Beyond this age, subsidiary products of metabolism and cell damage accumulate, and the phenotypes of ageing appear, causing disease formation. Among these age-related diseases, neurodegenerative diseases have drawn a lot of attention due to their irreversibility, lack of effective treatment, and accompanied social and economical burdens. In seeking to ameliorate ageing and age-related diseases, the search for anti-ageing drugs has been of much interest. Numerous studies have shown that the plant polyphenol, resveratrol (3,5,4'-trihydroxystilbene), extends the lifespan of several species, prevents age-related diseases, and possesses anti-inflammatory, and anti-cancer properties. The beneficial effects of resveratrol are believed to be associated with the activation of a longevity gene, SirT1. In this review, we discuss the pathogenesis of age-related neurodegenerative diseases including Alzheimer's disease, Parkinson's disease and cerebrovascular disease. The therapeutic potential of resveratrol, diet and the roles of stem cell therapy are discussed to provide a better understanding of the ageing mystery.

  14. Commissioning and Science Verification of JAST/T80

    Science.gov (United States)

    Ederoclte, A.; Cenarro, A. J.; Marín-Franch, A.; Cristóbal-Hornillos, D.; Vázquez Ramió, H.; Varela, J.; Hurier, G.; Moles, M.; Lamadrid, J. L.; Díaz-Martín, M. C.; Iglesias Marzoa, R.; Tilve, V.; Rodríguez, S.; Maícas, N.; Abri, J.

    2017-03-01

    Located at the Observatorio Astrofísico de Javalambre, the ’’Javalambre Auxiliary Survey Telescope’’ is an 80cm telescope with a unvignetted 2 square degrees field of view. The telescope is equipped with T80Cam, a camera with a large format CCD and two filter wheels which can host, at any given time, 12 filters. The telescope has been designed to provide optical quality all across the field of view, which is achieved with a field corrector. In this talk, I will review the commissioning of the telescope. The optical performance in the centre of the field of view has been tested with lucky imaging technique, providing a telescope PSF of 0.4’’, which is close to the one expected from theory. Moreover, the tracking of the telescope does not affect the image quality, as it has been shown that stars appear round even in exposures of 10minutes obtained without guiding. Most importantly, we present the preliminary results of science verification observations which combine the two main characteristics of this telescope: the large field of view and the special filter set.

  15. Prediction of Age at Menopause in Women of Suburban Areas in Chennai Using A Model of Fsh Over Age - A Pilot Study

    Directory of Open Access Journals (Sweden)

    SM Priyadharshini

    2014-02-01

    Full Text Available Objectives: The human ovary is characterized by early senescence and the end stage of ovarian activity is termed menopause. The age at which menopause occur is between 45 and 55 years world wide. The objective of this pilot study is to determine the age at menopause by using a model of FSH over age in women of sub urban region around Chennai, India. Materials and Methods: The subjects include 500 patients of age between 30 and 36 yrs with BMI ranging from 24-28.After recording their general profile and history, blood samples were obtained by venipuncture and hormone FSH was estimated on the day 3 of the menstrual cycle. Based on functional dependence of FSH in the form of exponential relation with age, a model was proposed. Using least square approximation the beta values were calculated. Results: With the help of beta values and using the cut off value of 40 IU/ml for FSH, this predicted model determined the age of menopause as 44.6yrs in women of sub urban region around Chennai. Conclusion: The age of menopause is different in various region worlds wide. According to this pilot study the suburban women of Chennai, attain menopause at an age of 44.6 years. Further exploration should be done to alleviate the role of diet, life style and ethnic variation on menopausal age and the impact of chronic disease like osteoporosis during the period of menopause.

  16. Forging of Mg-alloys AZ31 and AZ80

    Energy Technology Data Exchange (ETDEWEB)

    Viehweger, B.; Karabet, A.; Duering, M. [Brandenburg University of Technology, Interdisciplinary Research Centre for Lightweight Materials ' ' Panta Rhei' ' , Konrad-Wachsmann-Allee 17, 03046 Cottbus (Germany); Schaeffer, L. [Universidade Federal do Rio Grande do Sul, Porto Alegre (Brazil)

    2005-05-01

    Mg-wrought alloys recently became an engineer material of constantly increasing interest. The mechanical properties of extruded Mg-feedstock of the alloys AZ80 and AZ31 indicate their suitability for automotive applications in form of high-quality forgings. Therefore a detailed knowledge about the forming behaviour is of particular importance. In order to compare mechanical properties of available Mg-feedstock qualities compression tests at room temperature have been carried out by applying batches of AZ31- and AZ80-feedstock. Cylindrical specimens were made out of received continuously casted as well as extruded AZ31- and AZ80 - rods. A quantitative analysis of Mg-feedstock's microstructure has been carried out. The characterization of the deformability of applied Mg-feedstock under hot working conditions could be performed by means of uniaxial plain strain upsetting tests at temperatures between 300 and 450 C as well as logarithmic strain rates of 10{sup -1}, 1 and 10s{sup -1}. It is shown that the chosen parameter range ensures an enhanced deformability of continuously as well as extruded Mg-feedstock. The subsequently carried out determination of microstructural evolution could be related to obtained flow stress curves of applied batches of Mg-feedstock. Furthermore, FVM/FEM-systems have been employed in order to design a simplified geometry of heated forging dies suitable for forging tests. The tests have been carried out by means of a hydraulic press. During the tests their punch velocity has been varied between 1 and 40 mm/s. Hence numerically simulated results could be confirmed by practical tests. Exemplary forgings of a simplified shape were made out of all applied batches of Mg-feedstock. No remarkable failures have been detected. (Abstract Copyright [2005], Wiley Periodicals, Inc.) [German] Das Interesse an Mg-Knetlegierungen als Konstruktionswerkstoff fuer automobile Anwendung ist in juengster Zeit stark gewachsen. Daher ist eine detaillierte

  17. Climate change or urbanization? Impacts on a traditional coffee production system in East Africa over the last 80 years.

    Directory of Open Access Journals (Sweden)

    Juliana Jaramillo

    Full Text Available Global environmental changes (GEC such as climate change (CC and climate variability have serious impacts in the tropics, particularly in Africa. These are compounded by changes in land use/land cover, which in turn are driven mainly by economic and population growth, and urbanization. These factors create a feedback loop, which affects ecosystems and particularly ecosystem services, for example plant-insect interactions, and by consequence agricultural productivity. We studied effects of GEC at a local level, using a traditional coffee production area in greater Nairobi, Kenya. We chose coffee, the most valuable agricultural commodity worldwide, as it generates income for 100 million people, mainly in the developing world. Using the coffee berry borer, the most serious biotic threat to global coffee production, we show how environmental changes and different production systems (shaded and sun-grown coffee can affect the crop. We combined detailed entomological assessments with historic climate records (from 1929-2011, and spatial and demographic data, to assess GEC's impact on coffee at a local scale. Additionally, we tested the utility of an adaptation strategy that is simple and easy to implement. Our results show that while interactions between CC and migration/urbanization, with its resultant landscape modifications, create a feedback loop whereby agroecosystems such as coffee are adversely affected, bio-diverse shaded coffee proved far more resilient and productive than coffee grown in monoculture, and was significantly less harmed by its insect pest. Thus, a relatively simple strategy such as shading coffee can tremendously improve resilience of agro-ecosystems, providing small-scale farmers in Africa with an easily implemented tool to safeguard their livelihoods in a changing climate.

  18. Climate change or urbanization? Impacts on a traditional coffee production system in East Africa over the last 80 years.

    Science.gov (United States)

    Jaramillo, Juliana; Setamou, Mamoudou; Muchugu, Eric; Chabi-Olaye, Adenirin; Jaramillo, Alvaro; Mukabana, Joseph; Maina, Johnson; Gathara, Simon; Borgemeister, Christian

    2013-01-01

    Global environmental changes (GEC) such as climate change (CC) and climate variability have serious impacts in the tropics, particularly in Africa. These are compounded by changes in land use/land cover, which in turn are driven mainly by economic and population growth, and urbanization. These factors create a feedback loop, which affects ecosystems and particularly ecosystem services, for example plant-insect interactions, and by consequence agricultural productivity. We studied effects of GEC at a local level, using a traditional coffee production area in greater Nairobi, Kenya. We chose coffee, the most valuable agricultural commodity worldwide, as it generates income for 100 million people, mainly in the developing world. Using the coffee berry borer, the most serious biotic threat to global coffee production, we show how environmental changes and different production systems (shaded and sun-grown coffee) can affect the crop. We combined detailed entomological assessments with historic climate records (from 1929-2011), and spatial and demographic data, to assess GEC's impact on coffee at a local scale. Additionally, we tested the utility of an adaptation strategy that is simple and easy to implement. Our results show that while interactions between CC and migration/urbanization, with its resultant landscape modifications, create a feedback loop whereby agroecosystems such as coffee are adversely affected, bio-diverse shaded coffee proved far more resilient and productive than coffee grown in monoculture, and was significantly less harmed by its insect pest. Thus, a relatively simple strategy such as shading coffee can tremendously improve resilience of agro-ecosystems, providing small-scale farmers in Africa with an easily implemented tool to safeguard their livelihoods in a changing climate.

  19. Fully mechanised experimental face in a seam with a dip of over 80 degrees at Sotan Colliery, HUNOS

    Energy Technology Data Exchange (ETDEWEB)

    Garcia-Arguelles Martinez, A.; Lugue Cabal, V.

    1984-01-01

    As is well known, mining is being carried out in the Central Asturian coalfield in seams which are mostly vertical, thin and of irregular hypsometry. 58% of the reserves are at a dip of more than 60 degrees and 35% are between 30 and 60 degrees. Average seam thickness is 0.93 m. Faults and geological disturbances are common. In the 1970s drum shearers were tested and installed underground, principally the Russian TEMP and KT models, which allowed 25% of the winning faces to be mechanised. The remainder was won with pneumatic picks. Mechanisation of the winning operations with the machines commercially available was not sufficient however, as production potential had reched its maximum.

  20. Ku80 gene G-1401T promoter polymorphism and risk of gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Jia-Qi Li; Jie Chen; Nan-Nan Liu; Li Yang; Ying Zeng; Bin Wang; Xue-Rong Wang

    2011-01-01

    AIM: To evaluate the possible relationship between the Ku80 gene polymorphism and the risk of gastric cancer in China. METHODS: In this hospital-based case-control study of gastric cancer in Jiangsu Province, China, we investigated the association of the Ku80 G-1401T (rs828907) polymorphism with gastric cancer risk. A total of 241 patients with gastric cancer and 273 age- and sexmatched control subjects were genotyped and analyzed by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: The frequencies of genotypes GG, GT and TT were 65.6%, 22.8% and 11.6% in gastric cancer cases, respectively, and 75.8%, 17.6% and 6.6% in controls, respectively. There were significant differences between gastric cancer and control groups in the distribution of their genotypes (P = 0.03) and allelic requencies (P = 0.002) in the Ku80 promoter G-1401T polymorphism. CONCLUSION: The T allele of Ku80 G-1401T may be associated with the development of gastric cancer.

  1. Older Women's Development: A Comparison of Women in Their 60s and 80s on a Measure of Erikson's Developmental Tasks.

    Science.gov (United States)

    Norman, Suzanne M.; McCluskey-Fawcett, Kathleen; Ashcraft, Lisa

    2002-01-01

    Compares women from two ages groups in order to understand their development across the life span. Measures of Psychosocial Development, which assesses Erikson's developmental stages, were administered to 41 women in 2 cohorts (ages 60-70, ages 80-90). Age group differences in the resolution of Erikson's identity and trust developmental tasks were…

  2. Malnutrition is common in Ugandan children with cerebral palsy, particularly those over the age of five and those who had neonatal complications

    OpenAIRE

    Kakooza‐Mwesige, Angelina; Tumwine, James K; Eliasson, Ann‐Christin; Namusoke, Hanifa K.; Forssberg, Hans

    2015-01-01

    Abstract Aim Poor growth and malnutrition are frequently reported in children with cerebral palsy in developed countries, but there is limited information from developing countries. We investigated the nutritional status of Ugandan children with cerebral palsy and described the factors associated with poor nutrition. Methods We examined 135 children from two to 12 years with cerebral palsy, who attended Uganda's national referral hospital. A child was considered underweight, wasted, stunted o...

  3. Sexual activity and aging.

    Science.gov (United States)

    Ni Lochlainn, Mary; Kenny, Rose Anne

    2013-08-01

    Sexuality is an important component of emotional and physical intimacy that men and women experience throughout their lives. Research suggesting that a high proportion of men and women remain sexually active well into later life refutes the prevailing myth that aging and sexual dysfunction are inexorably linked. Age-related physiological changes do not render a meaningful sexual relationship impossible or even necessarily difficult. Many of these physiological changes are modifiable. There are various therapeutic options available to patients to achieve maximum sexual capacity in old age. This article reviews the prevalence of sexual activity among older adults, the problems these adults encounter with sexual activity, and the role of the health care professional in addressing these problems. The physiological sex-related changes that occur as part of the normal aging process in men and women are reviewed, as well as the effect of age-related physical and psychological illness on sexual function. The attitudes and perceptions of the media and general public toward sexual activity and aging are summarized. An understanding of the sexual changes that accompany the aging process may help general practitioners and other doctors to give practical and useful advice on sexuality as well as refute the misconception that aging equates to celibacy. A thorough awareness of this aspect of older people's quality of life can raise meaningful expectations for aging patients.

  4. The ESPARR cohort: the future of the serious injured aged 16 years and over (MAIS3=) with a traumatic brain injury (TBI) three years after the crash.

    OpenAIRE

    Tournier, Charlène; CHARNAY, Pierrette; LUAUTE, Jacques; Hours, Martine

    2014-01-01

    Introduction Few longitudinal studies investigated the long-term future of road accident victims. The ESPARR cohort has been followed for five years after the crash occurred. Objective To study the future of serious injured with TBI three years after their road accident. Methods The ESPARR cohort comprises 324 serious injured including 72 mild TBI (AIS2) and 70 moderate/severe TBI (AIS3+). 51 TBI2 and 49 TBI3+ responded to the questionnaire at three years. They are compared to 131 serious in...

  5. Structure and Thermal Parameters of Ni20Pd80 Alloy

    Institute of Scientific and Technical Information of China (English)

    S. Ahmad; A.B. Ziya; A. Aziz1; Z.I. Zafar

    2009-01-01

    The structure and thermal parameters of Ni20Pd80 alloy were studied by X-ray diffraction(XRD). The diffraction experiments performed in the temperature range of 308-1100 K revealed that the alloy formed a face centered cubic (fcc) Al-type structure. The temperature dependence of the lattice parameters was investigated by using the Bragg line displacement method showing that the lattice parameter increases with the increase of temperature. The mean linear thermal expansion (MLTE(%)), coefficient of thermal expansion (CTE, α), the characteristic Debye temperature (θD) and mean square amplitudes of vibration were determined from XRD data. The value of Debye temperature was found to be 253 K. It was found that temperature factor was independent of the static displacements.

  6. Symmetry and fundamental physics : Tom Kibble at 80

    CERN Document Server

    2014-01-01

    Tom Kibble is an inspirational theoretical physicist who has made profound contributions to our understanding of the physical world. To celebrate his 80th birthday a one-day symposium was held on March 13, 2013 at the Blackett Laboratory, Imperial College, London. This important volume is a compilation of papers based on the presentations that were given at the symposium. The symposium profiled various aspects of Tom's long scientific career. The tenor of the meeting was set in the first talk given by Neil Turok, director of the Perimeter Institute for Theoretical Physics, who described Tom as our guru and example . He gave a modern overview of cosmological theories, including a discussion of Tom's pioneering work on how topological defects might have formed in the early universe during symmetry-breaking phase transitions. Wojciech Zurek of Los Alamos National Laboratory continued with this theme, surveying analogous processes within the context of condensed matter systems and explaining the Kibble Zurek sc...

  7. The Big-Fish-Little-Pond Effect: Generalizability of Social Comparison Processes over Two Age Cohorts from Western, Asian, and Middle Eastern Islamic Countries

    Science.gov (United States)

    Marsh, Herbert W.; Abduljabbar, Adel Salah; Morin, Alexandre J. S.; Parker, Philip; Abdelfattah, Faisal; Nagengast, Benjamin; Abu-Hilal, Maher M.

    2015-01-01

    Extensive support for the seemingly paradoxical negative effects of school- and class-average achievement on academic self-concept (ASC)-the big-fish-little-pond effect (BFLPE)--is based largely on secondary students in Western countries or on cross-cultural Program for International Student Assessment studies. There is little research testing the…

  8. Electrodeposition and characteristics of Ni{sub 80}Fe{sub 20}/Cu composite wires

    Energy Technology Data Exchange (ETDEWEB)

    Li, X.P. [Department of Mechanical Engineering, National University of Singapore, Singapore 119260 (Singapore) and Division of Bioengineering, National University of Singapore, Singapore 119260 (Singapore)]. E-mail: mpelixp@nus.edu.sg; Seet, H.L. [Department of Mechanical Engineering, National University of Singapore, Singapore 119260 (Singapore); Fan, J. [Department of Mechanical Engineering, National University of Singapore, Singapore 119260 (Singapore); Yi, J.B. [Department of Mechanical Engineering, National University of Singapore, Singapore 119260 (Singapore)

    2006-09-15

    Electrodeposited Ni{sub 80}Fe{sub 20}/Cu composite wire has significant advantages over amorphous wire as sensing element for weak magnetic field sensors, such as orthogonal fluxgate sensors, due to its non-ferromagnetic and conductive core structure. In this study, the key processing parameters are investigated, including electrodeposition current density, duty cycle, electrolyte solution, pH value, applied magnetic field, effect of seeded layers, and post annealing.

  9. Evaluatie van het toezicht op snelheid op het 80 km/uur-wegennet in Flevoland : rapportage over fase 0, 1 en 2.

    NARCIS (Netherlands)

    Oei, H.-l. & Goldenbeld, C.

    1995-01-01

    In 1994, a speed campaign was conducted on 80 km/h roads in the Noord and Midden police districts in the Dutch province of Flevoland. This campaign was held before and after the summer holidays. In the Noord district, speed enforcement was carried out by using radar and a camera exclusively, and a f

  10. An assessment of the interpupillary distance, the inner and outer intercanthal distances in the normal Indian population from early neonatal period upto over 70 years of age: a study of 3500 subjects.

    Directory of Open Access Journals (Sweden)

    Shah K.

    2014-12-01

    Full Text Available Background and aim:\tThe normal range for anthropometric assessment of intercanthal, interpupillary and outer orbital dimensions is important and changes with age. This study was undertaken for setting a reference range for interpupillary distance, the inner and outer intercanthal distances in the normal Indian population, to observe the variation of these parameters with age, any differences in these parameters observed in male & female population and to find correlation with the refractive errors if any. Materials and Methods: This study was conducted in 3500 subjects of both sexes from birth till over 70 years of age, which presented to us in the outpatient department of M & J institute of Ophthalmology and Dr. Thakorbhai V Patel Eye Institute in the period ranging from August 2008 to January 2010. Results: A correlation with refractive errors has not been studied in previous literature. In our study, the range of IPDD in males was found to be 51.87-64.23mm & in females it was 51.16-62.23 mm, range of IPDN was 51.22 – 61.75 mm in males & 47.73-59.93 mm in females. The range of IICD was 18-36.09 mm in males & in females it was 19.38-34.89 mm. The range of OICD in males was 58- 92.8 mm & in females it was 56.63-88.56mm. Conclusion: We present the data for the neonatal children to the older age groups from the same population group. The standards based on local data reflect the potentially different patterns of craniofacial growth resulting from racial, ethnic & sexual differences. These could be relied upon in diagnosis of craniofacial syndromes and orbito-facial trauma or for planning reconstructive surgeries for the same.

  11. Age Is No Longer a Limit: Two Cases of Hepatectomy in Patients Over 90 Years Old

    Directory of Open Access Journals (Sweden)

    Shugo Uwatoko

    2015-02-01

    Full Text Available Hepatocellular carcinoma (HCC is a common malignant tumor with poor prognosis. The age of patients affected by HCC is considered to be increasing, and several studies have reported significantly higher rates of morbidity and mortality after hepatectomy for HCC in elderly patients. However, other studies have reported that the short- and long-term outcomes of surgery for HCC in elderly patients are similar to those in younger patients. Whether the indications for hepatic resection in elderly patients resemble those in younger patients has thus been questioned. We describe two cases of patients over 90 years old who underwent major hepatectomy for HCC, representing the oldest patients in the world to have done so.

  12. The effects of Tai Chi and Fitness Walking on the static balance ability in women over the age of 70%太极拳、健身走对70岁以上女性静态平衡能力的影响

    Institute of Scientific and Technical Information of China (English)

    陈晓彬

    2015-01-01

    目的::探讨太极拳、健步走对70岁以上女性静态平衡能力的影响,为开展科学健身提供指导。方法:采用分层抽样方式在某市区筛选146名70岁以上女性进行平衡能力测量,按照年龄分为70~79岁组和≥80岁组,按照锻炼方式分为太极拳、健身走和无规律运动,测量指标为包络面积、重心动摇轨迹长、能量损耗和X、Y方向上的轨迹长。结果:70~79岁组平衡能力好于≥80岁组(P健身走>太极拳;相同年龄组中,太极拳、健身走与无规律运动比较,均具有改善平衡能力的作用(P<0.01),其中太极拳的效果好于健身走(P<0.05~P<0.01)。结论:高龄老年人平衡能力随年龄增长出现下降趋势,体育锻炼可以减缓下降速度,其中太极拳的锻炼效果较好。%Objective:To investigate the effects of Tai Chi and Fitness Walking on the static balance ability of the elderly women,in order to provide scientific guidance. Methods:The balance abilities of 146 elderly women over the age of 70 from a city were investigated. The elderly women were divided into the 70 to 79 years old group and equal to and more than 80 years old group according to their ages. The exercise ways included the Tai Chi, Fitness Walking and irregular movement. The measure index included the envelope area,and the trace length of postural sway and X and Y direction. Results:The balance ability in 70 to 79 years old group was better than that in equal to and more than 80 years old group(P<0. 05 to P<0. 01). The balance ability began to decreased with the increase of age,which did not be affected by exercise. The decreasing range regularity from large to small was the irregular movement, Fitness Walking and Tai Chi in turn. The irregular movement,Fitness Walking and Tai Chi could improve the balance ability in the same age elderly women(P <0. 01),the effect of Tai Chi was better than that of Fitness Walking(P <0. 05 to P <0. 01

  13. Aging, Brain Size, and IQ.

    Science.gov (United States)

    Bigler, Erin D.; And Others

    1995-01-01

    Whether cross-sectional rates of decline for brain volume and the Performance Intellectual Quotient of the Wechsler Adult Intelligence Scale-Revised were equivalent over the years 16 to 65 was studied with 196 volunteers. Results indicate remarkably similar rates of decline in perceptual-motor functions and aging brain volume loss. (SLD)

  14. Changes in access to structural social capital and its influence on self-rated health over time for middle-aged men and women: a longitudinal study from northern Sweden.

    Science.gov (United States)

    Eriksson, Malin; Ng, Nawi

    2015-04-01

    Until recently, most studies on social capital and health have been cross-sectional making it difficult to draw causal conclusions. This longitudinal study used data from 33,621 individuals (15,822 men and 17,799 women) from the Västerbotten Intervention Program, to analyse how changes in access to individual social capital influence self-rated health (SRH) over time. Two forms of structural social capital, i.e. informal socializing and social participation, were measured. Age, sex, education, marital status, smoking, snuff, physical activity, alcohol consumption, high blood pressure, and body mass index were analysed as potential confounders. The association between changes in access to structural social capital and SRH in the follow-up was adjusted for SRH at baseline, as well as for changes in the socio-demographic and health-risk variables over time. The results support that changes in access to structural social capital over time impact on SRH. Remaining with no/low level of informal socializing over time increased the odds ratio for poor SRH for both men and women (OR of 1.45; 95%CI = 1.22-1.73 among men and OR of 1.56; 95%CI = 1.33-1.84 among women). Remaining with no/low levels of social participation was also detrimental to SRH in men and women (OR 1.14; 95%CI = 1.03-1.26 among men and OR 1.18; 95%CI = 1.08-1.29 among women). A decrease in informal socializing over time was associated with poor SRH for women and men (OR of 1.35; 95%CI = 1.16-1.58 among men and OR of 1.57; 95%CI = 1.36-1.82 among women). A loss of social participation had a negative effect on SRH among men and women (OR of 1.16; 95%CI = 1.03-1.30 among men and OR of 1.15; 95%CI = 1.04-1.27 among women). Gaining access to social participation was harmful for SRH for women (OR 1.17; 95%CI = 1.05-1.31). Structural social capital has complex and gendered effects on SRH and interventions aiming to use social capital for health promotion purposes require an awareness of its gendered nature.

  15. 40 CFR 80.93 - Individual baseline submission and approval.

    Science.gov (United States)

    2010-07-01

    ...: (i) Refinery block flow diagram, showing principal refining units; (ii) Principal refining unit... parameter for which a baseline value is required, per § 80.91: (i) Narrative of the development of...

  16. Aging, longevity and health

    DEFF Research Database (Denmark)

    Rasmussen, Lene Juel; Sander, Miriam; Wewer, Ulla M.;

    2011-01-01

    Session included speeches by Ralf Hemmingsen, Ulla Wewer, and Lene Juel Rasmussen and Keynote Addresses by four world renowned aging researchers: Povl Riis (The Age Forum), Bernard Jeune (University of Southern Denmark), George Martin (University of Washington, USA) and Jan Vijg (Albert Einstein School...

  17. Age, Wage and Productivity

    NARCIS (Netherlands)

    van Ours, J.C.; Stoeldraijer, L.

    2010-01-01

    Previous empirical studies on the effect of age on productivity and wages find contradicting results. Some studies find that if workers grow older there is an increasing gap between productivity and wages, i.e. wages increase with age while productivity does not or does not increase at the same pace

  18. Oral Health and Aging

    Science.gov (United States)

    ... of this page please turn JavaScript on. Feature: Oral Health and Aging Oral Health and Aging Past Issues / Summer 2016 Table of ... years. He spoke with NIH MedlinePlus magazine about oral health issues common in older adults. What has been ...

  19. Optimal Aging and Death

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan Lars; Strulik, Holger

    2010-01-01

    This study introduces physiological aging into a simple model of optimal intertemporal consumption. In this endeavor we draw on the natural science literature on aging. According to the purposed theory, the speed of the aging process and the time of death are endogenously determined by optimal...... health investments. At the same time, physiological aspects of the aging process inuence optimal savings and health investment. We calibrate the model for the average US male in 2000 and proceed to show that the calibrated model accounts well for the cross-country link between labor productivity and life...... expectancy in the same year ("the Preston curve"); cross-country income differences can explain differences in life expectancy at age 20 of up to a decade. Moreover, technological change in health care of about 1.1% per year can account for the observed shift in the Preston curve between 1980 and 2000....

  20. Optimal Aging and Death

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan Lars; Strulik, Holger

    2010-01-01

    This study introduces physiological aging into a simple model of optimal intertemporal consumption. In this endeavor we draw on the natural science literature on aging. According to the purposed theory, the speed of the aging process and the time of death are endogenously determined by optimal...... health investments. At the same time, physiological aspects of the aging process influence optimal savings and health investment. We calibrate the model for the average US male in 2000 and proceed to show that the calibrated model accounts well for the cross-country link between labor productivity...... and life expectancy in the same year ("the Preston curve"); cross-country income differences can explain differences in life expectancy at age 20 of up to a decade. Moreover, technological change in health care of about 1.1% per year can account for the observed shift in the Preston curve between 1980...

  1. Optimal Aging and Death

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan Lars; Strulik, Holger

    2010-01-01

    and life expectancy in the same year ("the Preston curve"); cross-country income differences can explain differences in life expectancy at age 20 of up to a decade. Moreover, technological change in health care of about 1.1% per year can account for the observed shift in the Preston curve between 1980......This study introduces physiological aging into a simple model of optimal intertemporal consumption. In this endeavor we draw on the natural science literature on aging. According to the purposed theory, the speed of the aging process and the time of death are endogenously determined by optimal...... health investments. At the same time, physiological aspects of the aging process influence optimal savings and health investment. We calibrate the model for the average US male in 2000 and proceed to show that the calibrated model accounts well for the cross-country link between labor productivity...

  2. Mitochondria and the aging heart

    Institute of Scientific and Technical Information of China (English)

    Ketul R Chaudhary; Haitham El-Sikhry; John M Seubert

    2011-01-01

    The average human life span has markedly increased in modern society largely attributed to advances in medical and therapeutic sciences that have successfully reduced important health risks.However,advanced age results in numerous alterations to cellular and subcellular components that can impact the overall health and function of an individual.Not surprisingly,advanced age is a major risk factor for the development of heart disease in which elderly populations observe increased morbidity and mortality.Even healthy individuals that appear to have normal heart fimction under resting conditions,actually have an increased susceptibility and vulnerability to stress.This is confounded by the impact that stress and disease can have over time to both the heart and vessels. Although, there is a rapidly growing body of literature investigating the effects of aging on the heart and how age-related alterations affect cardiac fimction, the biology of aging and underlying mechanisms remain unclear .In this review,we summarize effects of aging on the heart and discuss potential theories of cellular aging with special emphasis on mitochondrial dysfunction.

  3. Aging and skilled problem solving.

    Science.gov (United States)

    Charness, N

    1981-03-01

    Information-processing models of problem solving too often are based on restrictive age ranges. On the other hand, gerontologists have investigated few problem-solving tasks and have rarely generated explicit models. As this article demonstrates, both fields can benefit by closer collaboration. One major issue in gerontology is whether aging is associated with irreversible decrement or developmental plasticity. If both processes occur, then an appropriate strategy for investigating aging is to equate age groups for molar problem-solving performance and search for differences in the underlying components. This strategy was adopted to examine the relation of age and skill to problem solving in chess. Chess players were selected to vary widely in age and skill such that these variables were uncorrelated. Problem-solving and memory tasks were administered. Skill level was the only significant predictor for accuracy in both a choose-a-move task and a speeded end-game evaluation task. Age (negatively) and skill (positively) jointly determined performance in an unexpected recall task. Efficient chunking in recall was positively related to skill, though negatively related to age. Recognition confidence, though not accuracy, was negatively related to age. Thus despite age-related declines in encoding and retrieval of information, older players match the problem-solving performance of equivalently skilled younger players. Apparently, they can search the problem space more efficiently, as evidenced by taking less time to select an equally good move. Models of chess skill that stress that role of encoding efficiency, as indexed by chunking in recall, need to be modified to account for performance over the life span.

  4. Producing baryons from neutralinos in small H2 clumps over cosmological ages

    CERN Document Server

    Giraud, Edmond

    2012-01-01

    Extreme scattering events in quasars suggest the existence of dark H2 clumps of mass $\\rm \\sim 10^{-3} sim M_\\odot$ and size $\\rm \\sim 10 AU$. Such H2 clumps are extremely dense compared to WIMPs clumps of the same mass obtained by N-body simulations. A WIMP clump seeded by an H2 clump experiences a first infall during which its density increases by $\\rm 10^6$ in $\\rm \\sim 1 Myr$. In this poster I begin to explore the phenomenology of mixed clumps made with H2 and WIMPs. Molecular clouds built with clumps are efficient machines to transform smooth distributions of WIMPs into concentrated networks. If WIMPs are neutralinos trapped in such moleular clouds, they may either enrich the baryon sector over cosmological ages, or remain mixed with cold H2 clouds until the clumps evaporate either by collision or by stellar UV heating. One of the main drawbacks of CDM profiles, their overly dense cores, is briefly revisited in this context.

  5. Relationship of age over 50 years and serum prostate specific antigen in men of Beijing multicentre communities%北京多中心社区50岁以上男性年龄与前列腺特异性抗原的关系

    Institute of Scientific and Technical Information of China (English)

    李昕; 张祥华; 张争; 李淑清; 林健; BPC-BPH研究小组

    2012-01-01

    目的:探讨北京地区中老年男性年龄与血清前列腺特异性抗原(prostate-specific antigen,PSA)的关系.方法:采用多中心前瞻性分层多阶段整群不等比例随机抽样方法选取北京地区50岁以上中老年男性测定血清总PSA (T-PSA)、游离PSA (F-PSA)及F/T的比值,分析年龄与PSA水平的相关性.结果:共1 027例符合标准的研究对象,T-PSA及F-PSA与年龄呈正相关(r=0.208,P<0.001;r=0.230,P<0.001),F/T比值与年龄无相关性(r =0.055,P>0.079).T-PSA及F-PSA随年龄的增长而升高,50~ 59岁、60~69岁、70 ~79岁和80岁以上人群的95%可信区间上限分别为1.55、2.08、2.40和3.52 μg/L.结论:北京地区中老年男性T-PSA和F-PSA水平与年龄呈正相关,而F/T比值与年龄无相关性.%Objective; To investigate the relationship of prostate-specific antigen ( PSA) with age in men older than 50 years in Beijing. Methods; A cross-sectional study was performed in men aged over 50 years at communities in Beijing, and serum total PSA (T-PSA) and free PSA (F-PSA) levels were assayed. The relationship between age and PSA was analyzed with simple linear regression. Results; A total of 1 027 subjects were enrolled. Serum T-PSA and F-PSA levels were positively correlated with age ( r =0. 208 ,P 0.079). The upper limit (95% Cl) for serum PSA; 1.55 jxg/L for 50 -59 years, 2.08 p.g/L for 60-69 years, 2.40 jxg/L for 70 -79 years, 3. 52 (xg/L for 5s80 years. Conclusion; Of the men aged over 50 years in Beijing, there is a positive correlation between serum T-PSA, F-PSA and age; whereas F/T ratio isn' t correlated with age.

  6. GENDER-SELECTIVE INTERACTION BETWEEN AGING AND CARDIOVASCULAR SYMPATHETIC ACTIVITY

    Directory of Open Access Journals (Sweden)

    Thorat D Kiran

    2010-06-01

    Full Text Available Physiologically aging refers to the impaired ability to maintain homeostasis during external as wellas internal stresses. The sympathetic nervous system becomes tonically, progressively and markedlyactivated with aging in humans. Study is done to measure the cardiovascular sympatheticdysfunctions in the males and females of the different age groups. Total 80, healthy subjects nothaving any major illness and any chronic addiction, were selected for the study. All the subjects wereevaluated by using “CANWIN cardiac autonomic neuropathy analyzer” using the tests like Pulse rateby Palpatory method, Blood Pressure response to sudden standing and Sustained Handgrip test. In all the elderly subjects the sympathetic system was over activated and this over activation of the sympathetic system became more severe as the age advanced. Aging is accompanied by a greater increase in sympathetic activity in women than in men, independent of menopausal status. The study concludes that there is more marked influence of age on sympathetic nervous system activation and impaired sensitivity of baroreceptors in women than men.

  7. Envy, politics, and age.

    Science.gov (United States)

    Harris, Christine R; Henniger, Nicole E

    2013-01-01

    In the last 5 years, the phrase "politics of envy" has appeared more than 621 times in English-language newspapers, generally in opinion essays contending that political liberalism reflects and exploits feelings of envy. Oddly, this assertion has not been tested empirically. We did so with a large adult sample (n = 357). Participants completed a Dispositional Envy Scale and questions about political ideology, socioeconomic status, and age. Envy and age were moderately correlated; younger people reported greater envy. Political ideology and envy were weakly correlated; however, this relationship was not significant when controlling for age.

  8. Envy, Politics and Age

    Directory of Open Access Journals (Sweden)

    Christine R. Harris

    2013-03-01

    Full Text Available In the last 5 years, the phrase politics of envy has appeared more than 621 times in English-language newspapers, generally in opinion essays contending that political liberalism reflects and exploits feelings of envy. Oddly, this assertion has not been tested empirically. We did so with a large adult sample (n = 357. Participants completed a Dispositional Envy Scale and questions about political ideology, socioeconomic status, and age. Envy and age were moderately correlated; younger people reported greater envy. Political ideology and envy were weakly correlated; however, this relationship was not significant when controlling for age.

  9. The effect of different training modalities on physical fitness in women over 50 years of age

    Directory of Open Access Journals (Sweden)

    Lucas Melo Neves

    Full Text Available Abstract It is not yet clear which physical exercise protocols have greater potential to mitigate the functional decline in physical fitness (coordination, flexibility, strength, agility and cardiorespiratory capacity. Thus, the objective of this study was to compare different training modalities on physical fitness in women over 50 years of age and understand which training protocol is more effective for promoting significant improvements in physical fitness. The initial sample consisted of 79 subjects, of which 17 dropped out, resulting in a total of 62 subjects who completed the study and are included in the analysis (n = 62. The average age of the study population was 60.1±5.4 years, divided into five groups: aerobic training, concurrent training, multimodal training, functional training and control group. Physical fitness was analyzed through AAHPERD (American Alliance for Health, Physical Education, Recreation and Dance tests (0 and eighth weeks. The ANOVA analyses (aleatory effect show a main effect of time for coordination (p<0.001, strength (p = 0.004, agility (p<0.001 and cardiorespiratory capacity (p<0.001, and statistically significant interactions for coordination (p = 0.003 and cardiorespiratory capacity (p = 0.033. When comparing the average relative differences between the group (Δ%, significant improvement was observed in coordination and agility (p<0.001 in the multimodal and functional training groups. For cardiorespiratory fitness, there was a significant improvement in the aerobic, concurrent and multimodal training groups (p<0.001 and strength increased in the functional training group (p = 0.04. Functional training was demonstrated to be more effective at promoting significant improvements in physical fitness than the other investigated exercise protocols.

  10. Synchronising EDML and NorthGRIP ice cores using d18O of atmospheric oxygen (d18 Oatm) and CH4 measurements over MIS5 (80-123 kyr)

    DEFF Research Database (Denmark)

    Capron, E; Landais, A; Lemieux-Dudon, B

    2010-01-01

    of interest, CH4 records alone are not sufficient to construct a common gas timescale between the two cores. Millennial-scale variations of delta O-18(atm) are evidenced over MIS 5 both on the Antarctic and Greenland ice cores and are coupled to CH4 profiles to synchronise the NorthGRIP and EDML records...

  11. Aging and the aged in Aesopic fables.

    Science.gov (United States)

    Wortley, J

    1997-01-01

    Little attempt has been made to re-assess the attitudes to aging and old age of the ancient-medieval Greek-speaking world on the basis of the literary remains (which are common to both) since Richardson (1933). There are however some collections (proverbs, sayings, "purple passages" from literature and so forth) which include material revealing attitudes which are in fact quite different from those of today and which can even be surprising. One such collection, the large number of fables which more or less conform to the genre associated with Aesop, is here analyzed to isolate the texts which have to do with aging and the attitudes they reveal. Of the surprisingly few fables which touch upon the matter, most are distinctly complimentary. In most instances the elderly are seen to increase, rather diminish, in certain powers other than physical strength. Fables are found which characterize them as being astute, intelligent, crafty, loyal and, above all, capable of giving sound advice and good leadership when the situation requires it of them. The celebrated Fable of the Tortoise and the Hare, although it was not specifically interpreted in this way in ancient times, best sums up the general attitude: that dogged persistence (the characteristic of the elderly) will ultimately prove superior to all the erratic bursts of youthful speed anytime. Hence Cicero: "Old age is more spirited than youth, and stronger!"

  12. Effect of oral nitrates on pulse pressure and arterial elasticity in patients aged over 65 years with refractory isolated systolic hypertension: study protocol for a randomized controlled trial

    Science.gov (United States)

    2013-01-01

    Background Isolated systolic hypertension is a highly prevalent disease among the elderly. The little available evidence on the efficacy of nitrates for treating the disease is based on small experimental studies. Methods/design We performed a multicenter, randomized, double-blind, phase III, placebo-controlled trial in 154 patients aged over 65 years with refractory isolated systolic hypertension. Patients were randomized to placebo or 40 mg/day of extended-release isosorbide mononitrate added to standard therapy and titrated to 60 mg/day at week 6 if blood pressure exceeded 140/90 mmHg. The primary objective was to assess the effect on clinical pulse pressure of extended-release isosorbide mononitrate added to standard therapy in patients aged over 65 years with refractory isolated systolic hypertension after 3 months of treatment. The secondary objectives were as follows: to quantify the effect of adding the study drug on central blood pressure and vascular compliance using the augmentation index and pulse wave velocity; to evaluate the safety profile by recording adverse effects (frequency, type, severity) and the percentage of patients who had to withdraw from the trial because of adverse events; to quantify the percentage of patients who reach a clinical systolic blood pressure <140 mmHg or <130 mmHg measured by ambulatory blood pressure monitoring; and to quantify the change in pulse pressure measured by ambulatory blood pressure monitoring. Discussion Few clinical trials have been carried out to test the effect of oral nitrates on isolated systolic hypertension, even though these agents seem to be effective. Treatment with extended-release isosorbide mononitrate could improve control of systolic blood pressure without severe side effects, thus helping to reduce the morbidity and mortality of the disease. Trial registration EUDRACT Number: 2012-002988-10 PMID:24228894

  13. Protein oxidation and ageing

    DEFF Research Database (Denmark)

    Linton, S; Davies, Michael Jonathan; Dean, R T

    2001-01-01

    of redox-active metal ions that could catalyse oxidant formation. As a result of this decrease in antioxidant defences, and increased rate of ROS formation, it is possible that the impact of ROS increases with age. ROS are known to oxidise biological macromolecules, with proteins an important target....... If the argument that the impact of ROS increases with age is true, then proteins would be expected to accumulate oxidised materials with age, and the rate of such accumulation should increase with time, reflecting impaired inefficiency of homeostasis. Here we review the evidence for the accumulation of oxidised......, or modified, extra- and intra-cellular proteins in vivo....

  14. Growth hormone and aging

    OpenAIRE

    Bartke, Andrzej; Brown-Borg, Holly; Kinney, Beth; Mattison, Julie; Wright, Chris; Hauck, Steven; Coschigano, Karen; Kopchick, John

    2000-01-01

    The potential usefulness of growth hormone (GH) as an anti-aging therapy is of considerable current interest. Secretion of GH normally declines during aging and administration of GH can reverse age-related changes in body composition. However, mutant dwarf mice with congenital GH deficiency and GH resistant GH-R-KO mice live much longer than their normal siblings, while a pathological elevation of GH levels reduces life expectancy in both mice and men. We propose that the actions of GH on gro...

  15. Aging and sexuality.

    OpenAIRE

    Holzapfel, S.

    1997-01-01

    Recent research suggesting that a high proportion of men and women remain sexually active well into later life refutes the prevailing myth that aging and sexual dysfunction are inexorably linked. Age-related physiological changes do not render a meaningful sexual relationship impossible or even necessarily difficult. In men, greater physical stimulation is required to attain and maintain erections, and orgasms are less intense. In women, menopause terminates fertility and produces changes ste...

  16. Sleep and Aging

    Science.gov (United States)

    ... version of this page please turn Javascript on. Sleep and Aging About Sleep We all look forward to a good night's ... health and quality of life. Two Types of Sleep There are two types of sleep: non-rapid ...

  17. Aging Men and Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Thompson B

    2015-01-01

    Full Text Available Prostate cancer (PCa is one of the most commonly diagnosed cancers in men worldwide and its incidence increases with age, mainly affecting elderly men aged 60 and above. Factors known to be associated with the development and progression of PCa are age, family history, and race/ethnicity, with age being the most important factor. The reasons for the increased incidence and mortality due to prostate cancer in elderly men are not entirely clear. Continued exposure to environmental and dietary factors may lead to accumulation of genetic and epigenetic changes over the life-span, leading to altered expression and/or activity of tumor promoter and tumor suppressor genes. Changing levels of endogenous hormones (like androgens and metabolism in elderly men may also play a role in the development of prostate cancers which may be further influenced by testosterone replacement therapy. For many decades now preventative strategies and treatments such as radiation therapy or hormone therapy, and others have been administered to manage PCa; however current studies and evidence suggest that PCa is undertreated in elderly men, despite evidence of efficacy of these treatments, which leads to higher prevalence of mortality in this age group. Studies involving basic research, preventative and management strategies are still underway to understand the mechanisms of PCa development in elderly men and treatment of this disease in ageing male population.

  18. Envy, Politics, and Age

    OpenAIRE

    Harris, Christine R.; Henniger, Nicole E.

    2013-01-01

    In the last 5 years, the phrase politics of envy has appeared more than 621 times in English-language newspapers, generally in opinion essays contending that political liberalism reflects and exploits feelings of envy. Oddly, this assertion has not been tested empirically. We did so with a large adult sample (n = 357). Participants completed a Dispositional Envy Scale and questions about political ideology, socioeconomic status, and age. Envy and age were moderately correlated; younger pe...

  19. Envelhecimento e letramento: a leitura e a escrita na perspectiva de pessoas com mais de 60 anos de idade Aging and literacy: reading and writing from the perspective of people over 60

    Directory of Open Access Journals (Sweden)

    Rebecca Torquato

    2011-01-01

    Full Text Available Este artigo objetiva verificar os papéis que práticas de letramento assumem para pessoas com mais de 60 anos. A pesquisa foi realizada de um ponto de vista qualitativo/quantitativo, a partir da aplicação de um questionário junto a 40 sujeitos com idade superior a 60 anos. Foram coletadas informações sobre as práticas de leitura e de escrita, as suas dificuldades, bem como a relevância dessas práticas no próprio processo de envelhecimento. Verificou-se que os idosos referem dificuldades relacionadas a questões ortográficas, textuais e biológicas. As atividades de letramento são utilizadas, também, com o objetivo de melhorar a cognição. Além disso, eles reconhecem que essas atividades trazem benefícios para a promoção de um envelhecimento ativo e saudável.This paper aims at examining the roles played by literacy classes for adults older than 60. Forty individuals over 60 years old were interviewed for this quantitative/qualitative study. Information was gathered on their experiences with reading and writing, their difficulties and the perceived relevance of those classes on the ageing process. The participants indicated having difficulties with orthographic, textual and biological questions. The literacy activities were also used to improve their cognitive abilities. Moreover, the participants identified benefits of those activities for a healthy and active ageing.

  20. Cancer and aging

    DEFF Research Database (Denmark)

    Pedersen, Jacob K; Engholm, Gerda; Skytthe, Axel

    2016-01-01

    studies of cancer epidemiology and minimized the challenges often faced in many countries, such as uncertain identification of the study base, age misreporting, and low validity of the cancer diagnoses. However, methodological challenges still remain to be addressed, especially in cancer epidemiology...... studies among the elderly and the oldest-old. For example, a characteristic pattern for many cancer types is that the incidence increases up to a maximum at about ages 75-90 years and is then followed by a decline or a leveling off at the oldest ages. It has been suggested that the oldest individuals may...... be asymptomatic, or even insusceptible to cancer. An alternative interpretation is that this pattern is an artifact due to lower diagnostic intensity among the elderly and oldest-old caused by higher levels of co-morbidities in this age group. Currently, the available cancer epidemiology data are not able...

  1. Heart failure in very elderly population- a profile of heart failure in patients over the age of eighty

    Institute of Scientific and Technical Information of China (English)

    Christopher V.Chien; Dani Hackner; Ernst R. Schwarz

    2007-01-01

    Objective Heart failure is an epidemic in the elderly, but there is a striking lack of data in this clinically important patient population. We investigated the demographics, cardiac performance, and medication management of a segment of the hospital population in at least their eighth decade of life. Methods We retrospectively reviewed 75 records of heart failure patients who were 80 years of age or older. Records were reviewed for demographic information, presence or absence of diastolic dysfunction, evaluation of ejection fraction, and medication usage including angiotensin-concerting enzyme (ACE) inhibitors, angiotensin receptor antagonists (ARBs),beta-adrenergic blockers, digoxin, and aldosterone antagonists. Assessment for contra-indications to ACE inhibitor or ARBs use was also performed to assess co-morbidities that limit treatment of heart failure. Results The population of very elderly with heart failure is heterogeneous. We found a higher proportion of females as well as higher rates of diastolic dysfunction in patients aged ≥ 90 years compared to patients between the ages of 80-89 years. Usage of ACE inhibitors, ARBs and beta-adrenergic blockers was strikingly low throughout the very elderly population. While co-morbid conditions limited use of agents in many cases, there was a lack of explicit contra-indication in most patients not on an ACE inhibitor or an ARB. Conclusions Heart failure is not a single disease processes, but a continuum of disease processes that vary with age. The elderly with heart failure are an undertreated population, in part due to the multitude of co-morbidities that affect them. Further prospective studies are needed to better understand the physiology and ideal treatment regiment in this growing population.

  2. The differentiated effectiveness of a printed versus a Web-based tailored physical activity intervention among adults aged over 50

    NARCIS (Netherlands)

    Peels, D.A.; van Stralen, M.M.; Bolman, C.; Golsteijn, R.H.J.; de Vries, H.; Mudde, A.N.; Lechner, L.

    2014-01-01

    This study provides insight in the effectiveness of a print-delivered and a Web-based physical activity (PA) intervention (with or without additional environmental information on local PA possibilities) among people aged over 50. Intervention groups (print-delivered basic [PB; n = 439], print-delive

  3. The Differentiated Effectiveness of a Printed versus a Web-Based Tailored Physical Activity Intervention among Adults Aged over 50

    Science.gov (United States)

    Peels, D. A.; van Stralen, M. M.; Bolman, C.; Golsteijn, R. H. J.; de Vries, H.; Mudde, A. N.; Lechner, L.

    2014-01-01

    This study provides insight in the effectiveness of a print-delivered and a Web-based physical activity (PA) intervention (with or without additional environmental information on local PA possibilities) among people aged over 50. Intervention groups (print-delivered basic [PB; n = 439], print-delivered environmental [PE; n = 435], Web-based basic…

  4. Secondary Forest Age and Tropical Forest Biomass Estimation Using TM

    Science.gov (United States)

    Nelson, R. F.; Kimes, D. S.; Salas, W. A.; Routhier, M.

    1999-01-01

    The age of secondary forests in the Amazon will become more critical with respect to the estimation of biomass and carbon budgets as tropical forest conversion continues. Multitemporal Thematic Mapper data were used to develop land cover histories for a 33,000 Square kM area near Ariquemes, Rondonia over a 7 year period from 1989-1995. The age of the secondary forest, a surrogate for the amount of biomass (or carbon) stored above-ground, was found to be unimportant in terms of biomass budget error rates in a forested TM scene which had undergone a 20% conversion to nonforest/agricultural cover types. In such a situation, the 80% of the scene still covered by primary forest accounted for over 98% of the scene biomass. The difference between secondary forest biomass estimates developed with and without age information were inconsequential relative to the estimate of biomass for the entire scene. However, in futuristic scenarios where all of the primary forest has been converted to agriculture and secondary forest (55% and 42% respectively), the ability to age secondary forest becomes critical. Depending on biomass accumulation rate assumptions, scene biomass budget errors on the order of -10% to +30% are likely if the age of the secondary forests are not taken into account. Single-date TM imagery cannot be used to accurately age secondary forests into single-year classes. A neural network utilizing TM band 2 and three TM spectral-texture measures (bands 3 and 5) predicted secondary forest age over a range of 0-7 years with an RMSE of 1.59 years and an R(Squared) (sub actual vs predicted) = 0.37. A proposal is made, based on a literature review, to use satellite imagery to identify general secondary forest age groups which, within group, exhibit relatively constant biomass accumulation rates.

  5. Individual host factors associated with Onchocerca volvulus microfilarial densities 15, 80 and 180 days after a first dose of ivermectin.

    Science.gov (United States)

    Pion, Sébastien D S; Grout, Lise; Kamgno, Joseph; Nana-Djeunga, Hugues; Boussinesq, Michel

    2011-09-01

    Reduction in Onchocerca volvulus skin microfilarial densities after treatment with ivermectin shows wide between-host variation. Data from two separate studies conducted in Cameroon on onchocerciasis patients treated for the first time with ivermectin were analyzed to identify host factors associated with microfilarial density at different time-points after treatment. In one site (Nkam valley), the dataset included 103 adult males for whom age, number of palpable onchocercal nodules and microfilarial densities on D0 (pre-treatment), D15, D80 and D180 were available. In the other site (Vina valley), analyses were conducted on 965 individuals of both sexes aged 5 years and over; in this dataset, available information included age, gender, exact dose of ivermectin received, onchocerciasis endemicity level in the village of residence and microfilarial densities on D0 and D180. Negative binomial regression models of microfilarial density at the different intervals post-treatment were fitted, using maximum likelihood, with the available independent variables. Gender and age were found to be associated with microfilarial density on D180. The initial microfilarial density influenced post-treatment densities at all the time-points. All other things being equal, microfilarial densities on D180 were higher in individuals harbouring a higher number of nodules or living in communities with high endemicity levels. This study demonstrates that O. volvulus microfilarial density measured after a first treatment with ivermectin, and thus probably the rate of skin repopulation by microfilariae (mf) varies according to several host factors. Should such factors also influence ivermectin efficacy after repeated treatment, then they should be taken into account to determine whether sub-optimal responses to treatment reported from various areas in Africa are actually due to parasite-related factors, particularly to the emergence of resistant populations.

  6. The Ankle Injury Management (AIM) trial: a pragmatic, multicentre, equivalence randomised controlled trial and economic evaluation comparing close contact casting with open surgical reduction and internal fixation in the treatment of unstable ankle fractures in patients aged over 60 years.

    Science.gov (United States)

    Keene, David J; Mistry, Dipesh; Nam, Julian; Tutton, Elizabeth; Handley, Robert; Morgan, Lesley; Roberts, Emma; Gray, Bridget; Briggs, Andrew; Lall, Ranjit; Chesser, Tim Js; Pallister, Ian; Lamb, Sarah E; Willett, Keith

    2016-01-01

    BACKGROUND Close contact casting (CCC) may offer an alternative to open reduction and internal fixation (ORIF) surgery for unstable ankle fractures in older adults. OBJECTIVES We aimed to (1) determine if CCC for unstable ankle fractures in adults aged over 60 years resulted in equivalent clinical outcome compared with ORIF, (2) estimate cost-effectiveness to the NHS and society and (3) explore participant experiences. DESIGN A pragmatic, multicentre, equivalence randomised controlled trial incorporating health economic evaluation and qualitative study. SETTING Trauma and orthopaedic departments of 24 NHS hospitals. PARTICIPANTS Adults aged over 60 years with unstable ankle fracture. Those with serious limb or concomitant disease or substantial cognitive impairment were excluded. INTERVENTIONS CCC was conducted under anaesthetic in theatre by surgeons who attended training. ORIF was as per local practice. Participants were randomised in 1 : 1 allocation via remote telephone randomisation. Sequence generation was by random block size, with stratification by centre and fracture pattern. MAIN OUTCOME MEASURES Follow-up was conducted at 6 weeks and, by blinded outcome assessors, at 6 months after randomisation. The primary outcome was the Olerud-Molander Ankle Score (OMAS), a patient-reported assessment of ankle function, at 6 months. Secondary outcomes were quality of life (as measured by the European Quality of Life 5-Dimensions, Short Form questionnaire-12 items), pain, ankle range of motion and mobility (as measured by the timed up and go test), patient satisfaction and radiological measures. In accordance with equivalence trial US Food and Drug Administration guidance, primary analysis was per protocol. RESULTS We recruited 620 participants, 95 from the pilot and 525 from the multicentre phase, between June 2010 and November 2013. The majority of participants, 579 out of 620 (93%), received the allocated treatment; 52 out of 275 (19%) who received CCC later

  7. Magnesium and healthy aging.

    Science.gov (United States)

    Veronese, Nicola; Zanforlini, Bruno Micael; Manzato, Enzo; Sergi, Giuseppe

    2015-01-01

    Magnesium (Mg) is relatively stable in the intracellular compartment, although decreases linearly with advancing age. This begs the question as to whether Mg could be used as biomarker of aging. A biomarker of aging is a biological parameter of an organism that, in the absence of disease, better predicts functional capability at a later age than the chronological age. Bone and muscle Mg content might be useful biomarkers, but the need for biopsies and the heterogeneous distribution of Mg in bones and muscles strongly limit the application of these methods in clinical practice. Similar considerations can be made for urinary Mg assessment, particularly after a loading test. Markers of Mg in blood seem fairly unreliable as biomarkers of aging since they are strongly dependent upon renal function, do not reflect the intracellular Mg status, and, in some investigations, are within normal ranges although other Mg parameters are not. Other investigations (e.g. nuclear magnetic resonance with fluorescent probes) seem to be promising, but their availability remains limited.

  8. Aroma Constituents in Shanxi Aged Vinegar before and after Aging.

    Science.gov (United States)

    Liang, Jingjing; Xie, Jianchun; Hou, Li; Zhao, Mengyao; Zhao, Jian; Cheng, Jie; Wang, Shi; Sun, Bao-Guo

    2016-10-12

    Shanxi aged vinegar is one of the most famous Chinese traditional cereal vinegars produced by spontaneous solid-state fermentation. However, the aroma composition of Shanxi aged vinegar is still ambiguous. The Shanxi vinegars before and after aging were both analyzed by solvent-assisted flavor evaporation combined with gas chromatography-mass spectrometry (GC-MS) as well as gas chromatography-olfactometry (GC-O) in aroma extract dilution analysis. A total of 87 odor-active regions were found by GC-O, and 80 odor-active compounds were identified. By GC-MS/MS, in selected reaction monitoring mode, 30 important identifications were quantitated using authentic standards. In comparison, the aroma molecules for the vinegars before and after aging were almost the same; only their levels were altered, with mostly the esters and some compounds that produce pungent smells being lost and the levels of those from the Maillard reaction, especially the pyrazines (e.g., tetramethylpyrazine), being greatly increased. As for the aged vinegar, the compounds found to have high flavor dilution factors (>128) were 3-(methylthio)propanal, vanillin, 2,3-butanedione, tetramethylpyrazine, 3-methylbutanoic acid, γ-nonalactone, guaiacol, 3-(methylthio)propyl acetate, dimethyl trisulfide, phenylacetaldehyde, 2-ethyl-6-methylpyrazine, 2-acetylpyrazine, 2,3-dimethylpyrazine, furfural, and 3-hydroxy-2-butanone. However, the aroma compounds found at high concentrations (>25 μg/L) in the aged vinegar were acetic acid, followed by 2,3-butanedione, furfural, 3-hydroxy-2-butanone, tetramethylpyrazine, furfuryl alcohol, and 3-methylbutanoic acid.

  9. Sorption Behavior and Morphology of Plutonium in the Presence of Goethite at 25 and 80C

    Energy Technology Data Exchange (ETDEWEB)

    Zavarin, M; Zhao, P; Dai, Z; Carroll, S A; Kersting, A B

    2012-06-11

    In this study, we examined the sorption behavior of Pu at elevated temperatures in the presence of one relevant mineral, goethite ({alpha}-FeOOH), over a range of concentrations that span solubility-controlled to adsorption-controlled concentrations. We focused on the sorptive behavior of two common forms of Pu: aqueous Pu(IV) and intrinsic Pu(IV) nano-colloids at 25 and 80 C in a dilute pH 8 NaCl/NaHCO{sub 3} solution. The morphology of Pu sorbed to goethite was characterized using transmission electron microscopy (TEM). We examined the relative stability of PuO{sub 2} precipitates, PuO{sub 2} nano-colloids, Pu{sub 4}O{sub 7} surface precipitates, and monomeric sorbed Pu as a function of temperature and over a time scale of months.

  10. Increased gut hormones and insulin sensitivity index following a 3-d intervention with a barley kernel-based product: a randomised cross-over study in healthy middle-aged subjects.

    Science.gov (United States)

    Nilsson, Anne C; Johansson-Boll, Elin V; Björck, Inger M E

    2015-09-28

    Certain purified indigestible carbohydrates such as inulin have been shown to stimulate gut-derived hormones involved in glycaemic regulation and appetite regulation, and to counteract systemic inflammation through a gut microbiota-mediated mechanism. Less is known about the properties of indigestible carbohydrates intrinsic to food. The aim of this study was to investigate the possibility to affect release of endogenous gut hormones and ameliorate appetite control and glycaemic control by ingestion of a whole-grain cereal food product rich in NSP and resistant starch in healthy humans. In all, twenty middle-aged subjects were provided with a barley kernel-based bread (BB) or a reference white wheat bread during 3 consecutive days, respectively, in a randomised cross-over design study. At a standardised breakfast the following day (day 4), blood was collected for the analysis of blood (b) glucose regulation, gastrointestinal hormones, markers of inflammation and markers of colonic fermentation; 3 d of intervention with BB increased gut hormones in plasma (p) the next morning at fasting (p-glucagon-like peptide-1; 56%) and postprandially (p-glucagon-like peptide-2; 13% and p-peptide YY; 18%). Breath H₂ excretion and fasting serum (s) SCFA concentrations were increased (363 and 18%, respectively), and b-glucose (22%) and s-insulin responses (17%) were decreased after BB intervention. Insulin sensitivity index (ISI(composite)) was also improved (25%) after BB. In conclusion, 3 d of intervention with BB increased systemic levels of gut hormones involved in appetite regulation, metabolic control and maintenance of gut barrier function, as well as improved markers of glucose homoeostasis in middle-aged subjects, altogether relevant for the prevention of obesity and the metabolic syndrome.

  11. Expression and Identification of Inclusion Forming-related Domain of NS80 Nonstructural Protein of Grass Carp Reovirus

    Institute of Scientific and Technical Information of China (English)

    Chao FAN; Lan-lan ZHANG; Cheng-feng LEI; Qin FANG

    2009-01-01

    Grass carp reovirus (GCRV), a double stranded RNA virus that infects aquatic animals, often with disastrous effects, belongs to the genus Aquareovirus and family Reoviridea. Similar to other reoviruses, genome replication of GCRV in infected cells occurs in cytoplasmic inclusion bodies, also called viral factories. Sequences analysis revealed the nonstructural protein NS80, encoded by GCRV segment 4, has a high similarity with uNS in MRV(Mammalian orthoreoviruses), which may be associated with viral factory formation. To understand the function of the uNS80 protein in virus replication, the initial expression and identification of the immunogenicity of the GCRV NS80 protein inclusion forming-related region (335.742) was investigated in this study. It is shown that the over-expressed fusion protein was produced by inducing with IPTG at 28oC. In addition, serum specific rabbit antibody was obtained by using super purified recombinant NS80(335.742) protein as antigen. Moreover, the expressed protein was able to bind to anti-his-tag monoclonal antibody (mouse) and NS80(335-742) specific rabbit antibody. Further western blot analysis indicates that the antiserum could detect NS80 or NS80C protein expression in GCRV infected cells. This data provides a foundation for further investigation of the role of NS80 in viral inclusion formation and virion assembly.

  12. Characterization of Ku-deficient cells derived from Ku70-/- and Ku80-/- mice

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    @@ To determine the physiological roles of Ku70 and Ku80, we generated Ku70-/- and Ku80-/- knockout mice via targeted gene disruption (Nussenzweig et al. Nature 382, 1996; Ouyang et al. J Exp Med 186, 1997).

  13. 40 CFR 80.521 - What are the standards and identification requirements for diesel fuel additives?

    Science.gov (United States)

    2010-07-01

    ... Motor Vehicle Diesel Fuel; Nonroad, Locomotive, and Marine Diesel Fuel; and ECA Marine Fuel Motor... consumer in diesel motor vehicles or nonroad diesel engines. ... identification requirements for diesel fuel additives? 80.521 Section 80.521 Protection of...

  14. Feature tracking and aging

    Directory of Open Access Journals (Sweden)

    Rémy eAllard

    2013-07-01

    Full Text Available There are conflicting results regarding the effect of aging on second-order motion processing (i.e., motion defined by attributes other than luminance, such as contrast. Two studies (Habak & Faubert, 2000; Tang & Zhou, 2009 found that second-order motion processing was more vulnerable to aging than first-order motion processing. Conversely, Billino, Braun, Bremmer and Gegenfurtner (2011 recently found that aging affected first- and second-order motion processing by similar proportions. These three studies used contrast-defined motion as a second-order stimulus, but there can be at least two potential issues when using such a stimulus to evaluate age-related sensitivity losses. First, it has been shown that the motion system processing contrast-defined motion varies depending on the stimulus parameters. Thus, although all these three studies assumed that their contrast-defined motion was processed by a low-level second-order motion system, this was not necessarily the case. The second potential issue is that contrast-defined motion consists in a contrast modulation of a texture rich in high spatial frequencies and aging mainly affects contrast sensitivity at high spatial frequencies. Consequently, some age-related sensitivity loss to second-order motion could be due to a lower sensitivity to the texture rather than to motion processing per se. To avoid these two potential issues, we used a second-order motion stimulus void of high spatial frequencies and which has been shown to be processed by a high-level feature tracking motion system, namely fractal rotation (Lagacé-Nadon, Allard, & Faubert, 2009. We found an age-related deficit on second-order motion processing at all temporal frequencies including the ones for which no age-related effect on first-order motion processing was observed. We conclude that aging affects the ability to track features. Previous age-related results on second-order and global motion processing are discussed in light

  15. GALVANIC CORROSION AND INHIBITOR SELECTION BETWEEN 13Cr-L-80 STEEL AND N-80 STEEL%13Cr-L-80钢和N-80钢的电偶腐蚀及缓蚀剂研究

    Institute of Scientific and Technical Information of China (English)

    舒福昌

    2007-01-01

    针对文昌13-1/2油田套管设计中采用的13Cr-L-80 和N-80两种钢材偶接的情况,采用挂片失重法研究了两种金属在弱酸性完井液中的电偶腐蚀,筛选了抑制该电偶腐蚀的缓蚀剂,并对其缓蚀性能进行了评价.结果表明,在60 ℃下弱酸性完井液中两种材料偶接时,13Cr-L-80钢腐蚀速度下降,N-80钢的腐蚀速度上升,产生了明显的电偶腐蚀效应.从9种缓蚀剂中筛选出JC-6,在加量1.5%时,13Cr-L-80和N-80偶接、60 ℃时腐蚀速度分别降至0. 012和0.165 mm/a;质量比为9∶1的JC-6与PA复配物(代号JCP-6)使偶接钢材腐蚀速度进一步降低,在加量1.5%时,70 ℃时的腐蚀速度分别降至0.013和0.069 mm/a.

  16. Occupational Characteristics and Cognitive Aging in the Glostrup 1914 Cohort

    DEFF Research Database (Denmark)

    Gow, Alan J; Avlund, Kirsten; Mortensen, Erik L

    2014-01-01

    Objectives.The effect of occupational characteristics on cognitive change over 20 years was examined.Method.Occupational characteristics-intellectual challenge, physical hazards, and psychological demands-were assessed in the Glostrup 1914 Cohort when aged 60 years, and cognitive ability was asse......Objectives.The effect of occupational characteristics on cognitive change over 20 years was examined.Method.Occupational characteristics-intellectual challenge, physical hazards, and psychological demands-were assessed in the Glostrup 1914 Cohort when aged 60 years, and cognitive ability...... was assessed by 4 cognitive ability tests at ages 60, 70, and 80. RESULTS: Individuals in more intellectually challenging occupations had higher cognitive ability (r = .27-.38, p ages 50 and 60, p ...). In growth curve models, intellectual challenge continued to be associated with cognitive ability, controlling for sex, education, and social class. However, the association was reversed after accounting for cognitive ability at age 50; of 2 individuals with the same baseline level of cognitive ability...

  17. Modulating aging and longevity

    DEFF Research Database (Denmark)

    Rattan, Suresh

    Provides information and an evaluation of a variety of approaches tried for modulating aging and longevity, including dietary supplementation with antioxidants, vitamins and hormones, genetic engineering, life-style alterations, and hormesis through mild stress. After decades of systematic....... This book provides the most up-to-date information and a critical evaluation of a variety of approaches being tried for modulating aging and longevity, including dietary supplementation with antioxidants, vitamins and hormones, genetic engineering, life-style alterations, and hormesis through mild stress...

  18. 老年人躯体机能受损现状及其影响因素分析%Study on the declining physical functions and its influencing factors among the Chinese elderly aged 65 years and over

    Institute of Scientific and Technical Information of China (English)

    王德文

    2008-01-01

    目的 了解老年人躯体性日常生活能力(PADL)以及工具性日常生活能力(IADL)的受损现况及其影响因素.方法 利用中国老年健康长寿跟踪调查数据,对其中2002年PADL和IADL完全自理的6761人和3556人进行跟踪分析.结果 2002年1ADL(或PADL)完全自理的老年人到2005年时保持IADL(或PADL)完全自理的男女比例分别为59.3%和51.8%(或87.1%和81.5%).65~74、75~84、85~94以及95~105岁组的老年人,从2002年IADL或PADL完全自理到2005年时分别只有70.0%、47.0%、24.0%和15.0%保持IADL完全自理,约有95.0%、87.0%、74.0%和55.0%保持PADL完全自理.在控制性别、社会经济等变量后,老年人年龄越大、过去2年内患重大疾病的次数越多以及认知能力越低其IADL或PADL受损的可能性越大.结论 老年人躯体机能受损程度随着年龄增大加重.IADL受损程度严重于PADL.老年女性受损程度均比男性严重;老年人的年龄、过去2年内息重大疾病的次数以及认知能力对其躯体机能受损具有预测性作用.%Objective To understand the declining pattern of physical activities on daily living (PADL) and instrumental activities of daily living (IADL) and its influencing factors among the Chinese elderly aged 65 years and over. Methods Using data from 2002 and 2005 of the Chinese Longitudinal Health Longevity Study (CLHLS), 6761 Chinese elderly with fully independent PADL in 2002 and 3556 Chinese elderly with fully independent IADL in 2002 were studied. Results Data showed that the male elderly with fully dependent IADL at baseline in 2002 declined to 59.3% but kept the IADL in full independent in 2005, while that of female elderly were 51.8 % still keeping the IADL full independent in2005. Male elderly who at baseline with the PADL fully dependent in 2002 declined to 87.1% but kept the PADL full independent in 2005, while that of female elderly were 81.5% keeping the PADL full independent in 2005.There were only 70

  19. 50 CFR 80.23 - Allocation of funds between marine and freshwater fishery projects.

    Science.gov (United States)

    2010-10-01

    ... freshwater fishery projects. 80.23 Section 80.23 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE... RESTORATION ACTS § 80.23 Allocation of funds between marine and freshwater fishery projects. (a) Each coastal... for marine fisheries and projects having recreational benefits for freshwater fisheries. (1)...

  20. Design of an age hardening Mg-Li alloy and its aging behavior

    Institute of Scientific and Technical Information of China (English)

    Hao Zhong; Peiying Liu; Tietao Zhou; Huanxi Li

    2005-01-01

    An effort was made to design an age hardening Mg-Li alloy based on the phase diagrams calculated by means of "THERMO-CALC"-a thermodynamic software. Experiments were carried out to verify the calculated results by melting the alloy and examining its structure and aging behavior. The results show that the alloy possesses a structure constituent as expected, besides,the alloy has apparent aging behavior and over aging happens even at lower temperature. Metastable (Mg, Li, Al, Zn) phase has been identified when the hardness reaches the aging peak. With the increase of the aging time, (Mg, Li, Al, Zn) phase transforms to stable α phase and over aging happens.

  1. The prevalence rate and influential factors of diabetes among residents aged over 15 in Hubei Province%湖北省15岁以上居民糖尿病患病率及影响因素分析

    Institute of Scientific and Technical Information of China (English)

    潘琦; 郭立新; 肖琛嫦; 张璇; 陈功; 李十月; 燕虹

    2016-01-01

    目的:了解湖北省15岁以上居民糖尿病患病率及其影响因素,为糖尿病防控提供依据。方法于2013年10~11月,采取分层整群随机抽样方法,对抽取的湖北省20个县市,100个乡镇及街道,200个行政村级居委会的住户进行了入户问卷调查。采用SPSS18.0软件进行统计分析。结果共调查28555人,患糖尿病者823例(2.88%),其中城市4.37%,农村1.83%;男性2.61%,女性3.13%;不同年龄间糖尿病患病率以大于或等于65岁组患病率最高(6.61%),25~<35岁组最低(0.06%)。经多元Logistic回归分析,城乡、年龄、就业状况、医保类型、饮酒和肥胖是糖尿病的影响因素。结论湖北省糖尿病患病率处于一个相对较低的水平,不同特征人群的糖尿病患病有差异。%Objective To study the prevalence rate and influential factors of diabetes among residents aged over 15 in Hubei province to provide evidences for diabetes control .Methods Through stratified cluster sampling ,20 cities and counties ,including 100 blocks and towns ,200 communities and villages were sampled .Household survey was carried out from October to November , 2013 .Data was analyzed with SPSS18 .0 .Results In total ,28 555 eligible residents were surveyed ,among which 823 (2 .88% ) self‐reported being diagnosed as diabetes .The prevalence rate for urban and rural residents were found as 4 .37% and 1 .83% respective‐ly ,that of male and female as 2 .61% and 3 .13% respectively .Residents aged 65 and above reported highest prevalence rate (6 .61% ) while those from 25 to 34 years old had the lowest (0 .06% ) .Multiple logistic regression analysis yielded results that ru‐ral‐urban residence ,age ,occupational status ,type of medical insurance ,alcohol drinking and obesity were influential factors of diabe‐tes .Conclusion Prevalence rate of diabetes among residents aged over 15 in Hubei province was at

  2. Nutrition and Ageing.

    Science.gov (United States)

    Minuti, Andrea; Patrone, Vania; Giuberti, Gianluca; Spigno, Giorgia; Pietri, Amedeo; Battilani, Paola; Ajmone Marsan, Paolo

    2014-01-01

    The world elderly population is rapidly increasing. This demographic change represents a new challenge for the society and demands for a multisectorial intervention to promote a long, healthy, and active life span. Between the factors that contribute in fostering a long healthy life, the nutritional regime plays a central role and is recognized as a major factor in the onset of chronic diseases. A better understanding of the interaction between nutrition and ageing is essential to unravel the mechanisms responsible for these positive/negative effects and to identify diet components promoting the quality of life in the old age and to contribute to the prevention of late-life disabilities. At Università Cattolica del Sacro Cuore, the research activity in food science is focusing on four main objectives: food quality, food safety, functional foods and diet balancing. These objectives are the target of multidisciplinary ongoing and future research activities for a better understanding of the link between diet and ageing. Briefly, the different activities are addressed to the study of the following subjects: the most relevant factors affecting food choices and habits of old aged persons; the effects of long term low dose supplementation of conjugated linoleic acid in mouse; the use of low glycemic index and high resistant starch foods to prevent diabetes and obesity; the adjuvant effect of food bacteria for vaccination; the role of food ingredients in disease; the immunosuppression effect of mycotoxins, and its relevance in ageing people; the production of sustainable and natural antioxidant ingredients to encourage a healthy diet. Our research projects emphasize an holistic and integrated approach that, by bringing together complementary research groups, can combine the collective expertise and thus provide a comprehensive assessment of the role of nutrition in healthy ageing people.

  3. Fertility and age

    Directory of Open Access Journals (Sweden)

    Korula George

    2010-01-01

    Full Text Available The changing social scenario together with economic growth and an increase in job opportunities has to a great extent reduced gender inequality and has resulted in more and more older women seeking help from infertility clinics. Fertility and aging have always been closely linked and the age of the female partner remains the single most important factor in predicting success with treatment. Although tests for the ovarian reserve are an important informative tool and are helpful in selecting treatment options, they are poor predictors of the outcome.

  4. Nutritional Hormesis and Aging

    OpenAIRE

    Hayes, Daniel P.

    2009-01-01

    Nutritional hormesis has the potential to serve as a pro-healthy aging intervention by reducing the susceptibility of the elderly to various chronic degenerative diseases and thereby extending human healthspan. Supportive evidence for nutritional hormesis arising from essential nutrients (vitamins and minerals), dietary pesticides (natural and synthetic), dioxin and other herbicides, and acrylamide will be reviewed and discussed.

  5. Nutritional hormesis and aging.

    Science.gov (United States)

    Hayes, Daniel P

    2009-11-16

    Nutritional hormesis has the potential to serve as a pro-healthy aging intervention by reducing the susceptibility of the elderly to various chronic degenerative diseases and thereby extending human healthspan. Supportive evidence for nutritional hormesis arising from essential nutrients (vitamins and minerals), dietary pesticides (natural and synthetic), dioxin and other herbicides, and acrylamide will be reviewed and discussed.

  6. Charge Accumulation in LDPE and XLPE Conditioned at 80oC under Reduced Pressure

    DEFF Research Database (Denmark)

    Fleming, Robert J.; Henriksen, Mogens; Holbøll, Joachim T.

    1997-01-01

    The effects of thermal conditioning, under reduced pressure, on space accumulation in planar LDPE and XLPE samples under DC stress, have been investigated. The samples were conditioned prior to voltage application by being held at 80oC for 2-3 days in short circuit at rotary pump pressure. Some...... were then cooled to room temperature over a period of at least 6hr, still under rotary pump pressure and in short circuit, while others were cooled to room temperature in less than 1.5hr in the laboratory air. DC fields of 18kV/mm were then applied at room temperature, and space charge accumulation...

  7. 40 CFR 73.80 - Operation of allowance reserve program for conservation and renewable energy.

    Science.gov (United States)

    2010-07-01

    ... for conservation and renewable energy. 73.80 Section 73.80 Protection of Environment ENVIRONMENTAL... and Renewable Energy Reserve § 73.80 Operation of allowance reserve program for conservation and renewable energy. (a) General. The Administrator will allocate allowances from the Conservation...

  8. Body composition of 80-years old men and women and its relation to muscle strength, physical activity and functional ability

    DEFF Research Database (Denmark)

    Pederse, agnes N; Ovesen, Lars; Schroll, M;

    2002-01-01

    OBJECTIVE: To measure body composition and analyse the relation to muscle strength, physical activity and functional ability in healthy, old subjects, and to relate the results to an optimal BMI level for the elderly. SETTING: Subjects aged 80 years living at home from the 1914-population...... proposed guidelines for the elderly of an optimal BMI interval of 24-29 kg/m2. We found relations between body composition, muscle strength, physical activity and functional ability....

  9. Bioethics and aging

    Directory of Open Access Journals (Sweden)

    Domingo Castillo

    2012-05-01

    Full Text Available The purpose of this presentation is to discuss some concepts related to bioethics and ageing, specifically with regard to health and disease. Considerations on medical practice are made by referring to Kant and Heidelberg school of thought. Perception of time in the elderly and issues such as euthanasia and death are mentioned.

  10. Ageing and autoimmunity.

    Science.gov (United States)

    Fixa, B; Komárková, O; Nozicka, Z

    1975-01-01

    A total of 483 healthy persons from Czechoslovakia, divided into three age groups (below 40, 41-60 and above 61 years) were examined for eight types of autoantibodies (antibodies to epithelial cells and to colloid of thyroid gland, parietal cell antibodies, antibody to intersititial duct cells of parotis and to adrenal cells, anti-nuclear and anti-mitochondrial antibodies, intrinsic factor antibodies). A significantly increased occurrence was observed in the oldest age group, the results being more manifest in women. A conspicious increase was seen particularly in the thyroid antibodies. The results correspond to those of other authors from different geographic areas.

  11. Meta-analysis of the age-related positivity effect: age differences in preferences for positive over negative information.

    Science.gov (United States)

    Reed, Andrew E; Chan, Larry; Mikels, Joseph A

    2014-03-01

    In contrast to long-held axioms of old age as a time of "doom and gloom," mounting evidence indicates an age-related positivity effect in attention and memory. However, several studies report inconsistent findings that raise critical questions about the effect's reliability, robustness, and potential moderators. To address these questions, we conducted a systematic meta-analysis of 100 empirical studies of the positivity effect (N = 7,129). Results indicate that the positivity effect is reliable and moderated by theoretically implicated methodological and sample characteristics. The positivity effect is larger in studies that do not constrain (vs. constrain) cognitive processing-reflecting older adults' natural information processing preferences-and in studies incorporating wider (vs. narrower) age comparisons. Analyses indicated that older adults show a significant information processing bias toward positive versus negative information, whereas younger adults show the opposite pattern. We discuss implications of these findings for theoretical perspectives on emotion-cognition interactions across the adult life span and suggest future research directions.

  12. Age and Value Orientations

    Directory of Open Access Journals (Sweden)

    Asya Kh. Kukubayeva

    2013-01-01

    Full Text Available The present article deals with value orientations and their role in men’s lives, particularly, in young people’s lives. This notion was introduced by the American theoretical sociologist T. Parsons, one of the creators of modern theoretical sociology. The scientist made an attempt to construct the structural and analytical theory of social action, combining personal interests (needs and aims and situation, it takes place in. The issue of value orientations remains acute for psychology. Herein we have considered several most important works, relating to the considered issue. Age aspects of young people’s value orientations are of peculiar interest to us. When analyzing this phenomenon, one should take into consideration the psychological formations, inhere for a certain age. In fact every age has its unique structure, which may change when passing from one development stage to another. Basing on this fact, we’ve considered the values, depending on the age features of the youth, relying upon the works of the scientists, working with different categories of the youth, such as: teenagers, students, children of different nationalities. It is not surprising that most scientists have come to the conclusion that the chief role in value orientation belongs to a family, originates in relations with parents and teachers. The positive reinforcement to the future develops throughout life in accordance with a lifestyle of a family, society and political situation in a state.Life orientations as a type of value orientations show different types of young people’s preferences. Value structure of its consciousness has its own specific character, depending on the age peculiarities. The dynamics of the transition from one age to another is accompanied with the reappraisal of values, eventually, influencing the life strategy of the future generation

  13. Depression and Aging.

    Science.gov (United States)

    Hamilton, Marshall, Ed.

    1982-01-01

    Contains four articles related to depression and aging. Compares normal adults with those having a major depressive disorder. Focuses on life satisfaction in the elderly, describing an individualized measure of life satisfaction. Describes similarities and differences between grief and depression. Contains a psychometric analysis of the Zung…

  14. The effect of aging on the specialized conducting system: a telemetry ECG study in rats over a 6 month period.

    Science.gov (United States)

    Rossi, Stefano; Fortunati, Ilaria; Carnevali, Luca; Baruffi, Silvana; Mastorci, Francesca; Trombini, Mimosa; Sgoifo, Andrea; Corradi, Domenico; Callegari, Sergio; Miragoli, Michele; Macchi, Emilio

    2014-01-01

    Advanced age alone appears to be a risk factor for increased susceptibility to cardiac arrhythmias. We previously observed in the aged rat heart that sinus rhythm ventricular activation is delayed and characterized by abnormal epicardial patterns although conduction velocity is normal. While these findings relate to an advanced stage of aging, it is not yet known when and how ventricular electrical impairment originates and which is the underlying substrate. To address these points, we performed continuous telemetry ECG recordings in freely moving rats over a six-month period to monitor ECG waveform changes, heart rate variability and the incidence of cardiac arrhythmias. At the end of the study, we performed in-vivo multiple lead epicardial recordings and histopathology of cardiac tissue. We found that the duration of ECG waves and intervals gradually increased and heart rate variability gradually decreased with age. Moreover, the incidence of cardiac arrhythmias gradually increased, with atrial arrhythmias exceeding ventricular arrhythmias. Epicardial multiple lead recordings confirmed abnormalities in ventricular activation patterns, likely attributable to distal conducting system dysfunctions. Microscopic analysis of aged heart specimens revealed multifocal connective tissue deposition and perinuclear myocytolysis in the atria. Our results demonstrate that aging gradually modifies the terminal part of the specialized cardiac conducting system, creating a substrate for increased arrhythmogenesis. These findings may open new therapeutic options in the management of cardiac arrhythmias in the elderly population.

  15. The effect of aging on the specialized conducting system: a telemetry ECG study in rats over a 6 month period.

    Directory of Open Access Journals (Sweden)

    Stefano Rossi

    Full Text Available Advanced age alone appears to be a risk factor for increased susceptibility to cardiac arrhythmias. We previously observed in the aged rat heart that sinus rhythm ventricular activation is delayed and characterized by abnormal epicardial patterns although conduction velocity is normal. While these findings relate to an advanced stage of aging, it is not yet known when and how ventricular electrical impairment originates and which is the underlying substrate. To address these points, we performed continuous telemetry ECG recordings in freely moving rats over a six-month period to monitor ECG waveform changes, heart rate variability and the incidence of cardiac arrhythmias. At the end of the study, we performed in-vivo multiple lead epicardial recordings and histopathology of cardiac tissue. We found that the duration of ECG waves and intervals gradually increased and heart rate variability gradually decreased with age. Moreover, the incidence of cardiac arrhythmias gradually increased, with atrial arrhythmias exceeding ventricular arrhythmias. Epicardial multiple lead recordings confirmed abnormalities in ventricular activation patterns, likely attributable to distal conducting system dysfunctions. Microscopic analysis of aged heart specimens revealed multifocal connective tissue deposition and perinuclear myocytolysis in the atria. Our results demonstrate that aging gradually modifies the terminal part of the specialized cardiac conducting system, creating a substrate for increased arrhythmogenesis. These findings may open new therapeutic options in the management of cardiac arrhythmias in the elderly population.

  16. 47 CFR 80.107 - Service of private coast stations and marine-utility stations.

    Science.gov (United States)

    2010-10-01

    ...-utility stations. 80.107 Section 80.107 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... Operating Procedures-Land Stations § 80.107 Service of private coast stations and marine-utility stations. A private coast station or a marine-utility station is authorized to transmit messages necessary for...

  17. Rated age-of-acquisition norms for over 3,200 German words.

    Science.gov (United States)

    Birchenough, Julia M H; Davies, Robert; Connelly, Vincent

    2016-03-04

    Words that have been learned early in life are responded to faster than words that have been acquired later. Subjective ratings of acquisition ages have been successfully employed to study the effect of age of acquisition (AoA). Although a large number of norms exist in many languages, fewer are available for German. Therefore, subjective AoA ratings for 3,259 German words were collected online, including 2,363 nouns and 473 verbs. These words were presented in lists of 140 words, and participants rated the age in years at which they had first learned each word. A split-half correlation testified to a high internal reliability. There were also high correlations with rated AoA values for subsets of the items that had been collected in previous studies, in both German and English. Age and gender were found to influence the ratings very weakly, in that older and male participants tended to give slightly higher age ratings. Education, multilingualism, and frequent usage of languages other than German did not exert an influence on the rating values. These new ratings will extend the currently existing norms available for language and reading research across languages and will provide researchers with a wider choice of word stimuli. The ratings are available expressed in two measurements: age in years, and AoA rated on a 7-point Likert scale.

  18. HIV after 40 in rural South Africa: A life course approach to HIV vulnerability among middle aged and older adults.

    Science.gov (United States)

    Mojola, Sanyu A; Williams, Jill; Angotti, Nicole; Gómez-Olivé, F Xavier

    2015-10-01

    South Africa has the highest number of people living with HIV in the world (over 6 million) as well as a rapidly aging population, with 15% of the population aged 50 and over. High HIV prevalence in rural former apartheid homeland areas suggests substantial aging with HIV and acquisition of HIV at older ages. We develop a life course approach to HIV vulnerability, highlighting the rise and fall of risk and protection as people age, as well as the role of contextual density in shaping HIV vulnerability. Using this approach, we draw on an innovative multi-method data set collected within the Agincourt Health and Demographic Surveillance System in South Africa, combining survey data with 60 nested life history interviews and 9 community focus group interviews. We examine HIV risk and protective factors among adults aged 40-80, as well as how and why these factors vary among people at older ages.

  19. [Epidermal aging and anti-aging strategies].

    Science.gov (United States)

    Wohlrab, J; Hilpert, K; Wolff, L

    2016-02-01

    Epithelial senescence is a complex process depending on intrinsic as well as extrinsic factors (e.g., UV or IR light, tobacco smoke) and must be seen in the context of the aging process especially of the corium and the subcutis. Morphological alterations become apparent in the form of epithelial atrophy, structural changes within the basal membrane, and a decrease in cell count of melanocytes and Langerhans cells. Signs of cellular senescence are reduced proliferation of keratinocytes, cumulation of dysplastic keratinocytes, various mutations (e.g., c-Fos/c-Jun, STAT3, FoxO1), as well as multiple lipid or amino acid metabolic aberrations (e.g., production of advanced glycation endproducts). This causes functional changes within the physical (lipid deficiency, water distribution dysfunction, lack of hygroscopic substances), chemical (pH conditions, oxygen radicals), and immunological barrier. Prophylactically, barrier-protective care products, antioxidant substances (e.g., vitamin C, B3, E, polyphenols, flavonoids), sunscreen products/measurements, and retinoids are used. For correcting alterations in aged epidermis, chemical peelings (fruit acids, β-hydroxy acid, trichloroacetic acid, phenolic compounds), non-ablative (IPL, PDL, Nd:YAG) as well as ablative (CO2, Erbium-YAG) light-assisted methods are used.

  20. Olfaction and Aging: A Mini-Review.

    Science.gov (United States)

    Attems, Johannes; Walker, Lauren; Jellinger, Kurt A

    2015-01-01

    Decreased olfactory function is very common in the older population, being present in >50% of individuals aged between 65 and 80 years and in 62-80% of those >80 years of age. Smell dysfunction significantly influences physical well-being, quality of life, nutritional status as well as everyday safety and is associated with increased mortality. Multiple factors contribute to age-related olfactory sensory loss, including nasal engorgement, cumulative damage of the olfactory epithelium from environmental insults, a reduction in mucosal metabolizing enzymes, sensory loss of receptor cells to odorants, and changes in neurotransmitter and neuromodulator systems. In addition, structural and functional abnormalities of the olfactory epithelium, olfactory bulb, central olfactory cortex, and basic olfactory circuitry, which are related to the neuronal expression of aberrant proteins in these areas, may result in olfactory sensory impairment in aging and neurodegenerative diseases. Impaired odour identification is associated with a decrease in cognitive abilities and memory decline. A reduction in the sense of smell is considered to potentially represent an early and important warning of neurodegenerative disorders, particularly of Parkinson's disease and Alzheimer's disease, and, in mild cognitive impairment, olfactory impairment may herald progression to dementia. Further investigations of the potential role of olfactory dysfunction in the early diagnosis and treatment of neurodegenerative diseases are warranted.

  1. Humor, Aggression, and Aging.

    Science.gov (United States)

    Barrick, Ann Louise; And Others

    Although humor is an important phenomenon in human interactions, it has rarely been studied in the elderly. An understanding of responses to humor in aggressive cartoons as a function of advancing age would provide information regarding both the development of humor and the negative (aggressive) emotional experiences of the elderly. This study was…

  2. Normal and aging hair biology and structure 'aging and hair'.

    Science.gov (United States)

    Goodier, Molly; Hordinsky, Maria

    2015-01-01

    Much like an individual's hairstyle, hair fibers along the scalp see a number of changes over the course of one's lifetime. As the decades pass, the shine and volume synonymous with youthful hair may give way to thin, dull, and brittle hair commonly associated with aging. These changes are a result of a compilation of genetic and environmental elements influencing the cells of the hair follicle, specifically the hair follicle stem cells and melanocytes. Telomere shortening, decrease in cell numbers, and particular transcription factors have all been implicated in this process. In turn, these molecular alterations lead to structural modifications of the hair fiber, decrease in melanin production, and lengthening of the telogen phase of the hair cycle. Despite this inevitable progression with aging, there exists an array of treatments such as light therapy, minoxidil, and finasteride which have been designed to mitigate the effects of aging, particularly balding and thinning hair. Although each works through a different mechanism, all aim to maintain or potentially restore the youthful quality of hair.

  3. Sleep and Aging: Insomnia

    Science.gov (United States)

    ... Aging Insomnia Insomnia is the most common sleep complaint at any age. It affects almost half of ... A-Z | videos A-Z | training | about us | Customer Support | site map National Institute on Aging | U.S. ...

  4. Structural and electronic stability of a volleyball-shaped B80 fullerene

    Science.gov (United States)

    Wang, Xiao-Qian

    2010-10-01

    We have studied the structural and electronic characteristics of a volleyball-shaped B80 cage using first-principles density-functional calculations. In contrast to the popularly ratified “magic” B80 buckyball with 20 hexagonal pyramids and 12 hollow pentagons, the volleyball-shaped B80 constitutes 12 pentagonal pyramids, 8 hexagonal pyramids, and 12 hollow hexagons. The B80 volleyball is markedly more stable than the previously assumed magic B80 buckyball, which is attributed to the improved aromaticity associated with the distinct configuration.

  5. Cognitive Impairment and Age-Related Vision Disorders: Their Possible Relationship and the Evaluation of the Use of Aspirin and Statins in a 65 Years-and-Over Sardinian Population

    Science.gov (United States)

    Mandas, Antonella; Mereu, Rosa Maria; Catte, Olga; Saba, Antonio; Serchisu, Luca; Costaggiu, Diego; Peiretti, Enrico; Caminiti, Giulia; Vinci, Michela; Casu, Maura; Piludu, Stefania; Fossarello, Maurizio; Manconi, Paolo Emilio; Dessí, Sandra

    2014-01-01

    Neurological disorders (Alzheimer’s disease, vascular and mixed dementia) and visual loss (cataract, age-related macular degeneration, glaucoma, and diabetic retinopathy) are among the most common conditions that afflict people of at least 65 years of age. An increasing body of evidence is emerging, which demonstrates that memory and vision impairment are closely, significantly, and positively linked and that statins and aspirin may lessen the risk of developing age-related visual and neurological problems. However, clinical studies have produced contradictory results. Thus, the intent of the present study was to reliably establish whether a relationship exist between various types of dementia and age-related vision disorders, and to establish whether statins and aspirin may or may not have beneficial effects on these two types of disorders. We found that participants with dementia and/or vision problems were more likely to be depressed and displayed worse functional ability in basic and instrumental activities of daily living than controls. Mini mental state examination scores were significantly lower in patients with vision disorders compared to subjects without vision disorders. A closer association with macular degeneration was found in subjects with Alzheimer’s disease than in subjects without dementia or with vascular dementia, mixed dementia, or other types of age-related vision disorders. When we considered the associations between different types of dementia and vision disorders and the use of statins and aspirin, we found a significant positive association between Alzheimer’s disease and statins on their own or in combination with aspirin, indicating that these two drugs do not appear to reduce the risk of Alzheimer’s disease or improve its clinical evolution and may, on the contrary, favor its development. No significant association in statin use alone, aspirin use alone, or the combination of these was found in subjects without vision

  6. Consumer sensory acceptance and value of wet-aged and dry-aged beef steaks.

    Science.gov (United States)

    Sitz, B M; Calkins, C R; Feuz, D M; Umberger, W J; Eskridge, K M

    2006-05-01

    To determine sensory preference and value of fresh beef steak differing in aging technique, strip steaks were evaluated by consumers in Denver (n = 132 consumers) and Chicago (n = 141 consumers). Wet-aged Choice strip loins were matched with dry-aged Choice strip loins, whereas wet-aged Prime strip loins were matched with dry-aged Prime strip loins. Dry-aged strip loins were commercially aged in air in a controlled environment for 30 d and vacuum-aged for 7 d during shipping and storage. Wet-aged strip loins were vacuum-packaged and aged for 37 d in a 1 degrees C cooler. Pairs of strip loins were matched to similar Warner-Bratzler shear force values and marbling scores. Twelve sensory evaluation panels (of 12 scheduled panelists each) were conducted over a 3-d period in each city. Individual samples from a pair of steaks were evaluated by the panelists for sensory traits. Bids were placed on the samples after sensory traits were obtained utilizing a variation of the Vickery auction with silent, sealed bids. No significant differences for sensory traits of flavor, juiciness, tenderness, or overall acceptability were detected between wet-aged Choice samples and dry-aged Choice samples. Although wet-aged Choice samples were numerically superior for all sensory traits, consumers placed similar bid values (P = 0.12) on wet- and dry-aged Choice samples ($3.82 per 0.45 kg and $3.57 per 0.45 kg, respectively). Wet-aged Prime samples were rated more desirable (P dry-aged Prime samples. Wet-aged Prime samples were valued at $4.02 per 0.45 kg, whereas dry-aged Prime samples brought $3.58 per 0.45 kg (P = 0.008). Consumers (29.3%) who preferred the dry-aged Choice samples over the wet-aged Choice samples were willing to pay $1.99/0.45 kg more (P dry-aged samples. The consumers who preferred the wet-aged Choice over the dry-aged Choice samples (39.2%) were willing to pay $1.77/0.45 kg more (P aged Prime over dry-aged Prime samples (45.8%) paid $1.92/0.45 kg more (P dry-aged

  7. MYB80, a regulator of tapetal and pollen development, is functionally conserved in crops.

    Science.gov (United States)

    Phan, Huy A; Li, Song F; Parish, Roger W

    2012-01-01

    The Arabidopsis AtMYB80 transcription factor (formerly AtMYB103) regulate genes essential for tapetal and pollen development. One of these genes, coding for an aspartic protease (UNDEAD), may control the timing of tapetal programmed cell death (PCD). In crop plants such as rice and wheat, abiotic stresses lead to abnormal tapetal development resulting in delayed PCD. Manipulation of AtMYB80 function has been used to develop a reversible male sterility system applicable to hybrid crop production. MYB80 homologs were cloned from wheat, rice, canola and cotton. The promoters of the homologs drove temporal and spatial expression patterns of the GUS reporter gene in the tapetum and microspores of Arabidopsis anthers identical to the AtMYB80 promoter. A short region is conserved in all five MYB80 promoters. The MYB80 homolog genes, driven by the AtMYB80 or their respective promoters, rescued the atmyb80 mutant, completely restoring male fertility. The canola MYB80 was fused to the EAR (ERF-associated amphiphilic repression) repressor and canola plants transgenic for the construct exhibited premature tapetal degradation and subsequent pollen abortion. The five MYB80 homologs all shared a 44 amino acid sequence immediately adjacent to the R2R3 domain which appears to be necessary for MYB80 function.

  8. Stability of the age distribution of measles cases over time during outbreaks in Bangladesh, 2004-2006.

    Science.gov (United States)

    Wiesen, Eric; Wannemuehler, Kathleen; Goodson, James L; Anand, Abhijeet; Mach, Ondrej; Thapa, Arun; O'Connor, Patrick; Linayage, Jayantha; Diorditsa, Serguei; Hasan, A S M Mainul; Uzzaman, Sharif; Jalil Mondal, M D Abdul

    2011-07-01

    Despite recommendations from WHO to conduct measles outbreak response vaccination campaigns based on the age distribution of cases at the beginning of an outbreak, few data exist to specifically examine whether the age distribution of cases remains constant over time in a measles outbreak. This analysis explores this question with use of measles outbreak surveillance data from Bangladesh from the period 2004-2006. Pearson χ(2) tests were conducted of age distributions over 2 periods during 41 large laboratory-confirmed measles outbreaks. Statistically significant changes in age distribution over time were observed in 24% of the outbreaks. No single pattern was detected in the shifts in age distribution; however, an increase in the proportion of cases occurring among infants outbreaks. These findings suggest a need to consider the possibility of a shift in the age distribution over time when planning an outbreak response vaccination campaign.

  9. [Effect of concomitant substances and addition order on the adsorption of Tween 80 on sand].

    Science.gov (United States)

    Xu, Wei; Zhao, Yong-sheng; Li, Sui; Dai, Ning

    2008-08-01

    Adsorption of Tween 80 on sand was investigated, and the effect of inorganic salts (CaCl2), anionic surfactant (SDS) and lignosulphonates (sodium lignosulphonate or ammonium lignosulphonate) on the adsorption of Tween 80 on sand were evaluated at 25 degrees C. The results show that saturated adsorption amount of Tween 80 on sand enhance when CaCl2 or SDS is added into flushing solution of Tween 80. And the adsorption of Tween 80 on sand increase with the increase of molar fraction of CaCl2 or SDS in mixed flushing solution. And adsorption amount of Tween 80 on sand also enhance when SDS is added into sand firstly. The effects of mixing ratios and addition order of lignosulphonates on adsorption of Tween 80 were considered. The results show that with the increase of molar fraction of lignosulphonates in mixing flushing solution, adsorption amount of Tween 80 on sand decrease. The adsorption amount of Tween 80 reduce 20%-75% due to the exist of ammonium lignosulphonate is superior to sodium lignosulphonate (10%-60%) when mix the lignosulphonates-Tween 80 at the total mass ratios of 1:10, while the adsorption amount of Tween 80 reduce 70%-90% at the total mass ratios of 1:2. Lignosulphonates added into sand firstly is more efficient than that together. Therefore,use of lignosulphonates as a preflush can reduce the adsorption of surfactants on sand and is a better method to applied in in situ flushing.

  10. Effect of Age on Hypertension: Analysis of Over 4,800 Referred Hypertensive Patients

    Directory of Open Access Journals (Sweden)

    Anderson Gunnar

    1999-01-01

    Full Text Available We evaluate in this study the factors associated with the effect of age on blood pressure in more than 4800 patients. Their physicians referred them to evaluate for secondary causes for their hypertension. Factors studied included history and physical examination, serum sodium, potassium and creatinine, a stimulated plasma renin and catecholamine. We also studied the blood pressure response to infusion of either saralasin (an angiotensin II analogue or enalapril (an angiotensin converting enzyme inhibitor, and plasma aldosterone and cortisol after infusion of saline. We measured serum thyroxin and thyroid stimulating hormone concentrations on 1061 consecutive patients in this series. The results of our study show that increased age is associated with a significant increase in the prevalence of hypertension and especially of systolic hypertension after age 60 years. Increased obesity between age 30-50 years is associated with significant increases in diastolic blood pressure and this trend is also seen in African-Americans who are heavier than whites. Increased age is associated with an increased prevalence of secondary forms of hypertension including atherosclerotic renovascular hypertension, renal insufficiency and primary hypothyroidism.

  11. Aging and space travel

    Science.gov (United States)

    Mohler, S. R.

    1982-01-01

    The matter of aging and its relation to space vehicle crewmembers undertaking prolonged space missions is addressed. The capabilities of the older space traveler to recover from bone demineralization and muscle atrophy are discussed. Certain advantages of the older person are noted, for example, a greater tolerance of monotony and repetitious activities. Additional parameters are delineated including the cardiovascular system, the reproductive system, ionizing radiation, performance, and group dynamics.

  12. Spin-orbit ab initio curves of 80Se+2 ion and the assignment of photoelectron spectra of 80Se2 molecule

    Institute of Scientific and Technical Information of China (English)

    Yan Bing; Pan Shou-Fu; Guo Qing-Qun

    2008-01-01

    This paper carries out ab initio calculations to study the 80Se2(X3∑-g)state and 80Se+2(X2∏g),80Se+2(a4∏g)states by using completed active space self-consistent field and multi-reference second order perturbation theory.The electronic curves of these states including spin-orbit coupling are calculated,and then the spectroscopic parameters are obtained.The photoelectron spectra of 80Se2 molecule in gas phase are assigned according to Franck-Condon analysis based on calculated potential energy curves.The ionization energies of 80Se2 molecule are determined by the present calculation.

  13. Effect of annatto addition and bleaching treatments on ultrafiltration flux during production of 80% whey protein concentrate and 80% serum protein concentrate.

    Science.gov (United States)

    Adams, Michael C; Zulewska, Justyna; Barbano, David M

    2013-04-01

    The goals of this study were to determine if adding annatto color to milk or applying a bleaching process to whey or microfiltration (MF) permeate influenced ultrafiltration (UF) flux, diafiltration (DF) flux, or membrane fouling during production of 80% whey protein concentrate (WPC80) or 80% serum protein concentrate (SPC80). Separated Cheddar cheese whey (18 vats using 900 kg of whole milk each) and MF permeate of skim milk (18 processing runs using 800 kg of skim milk each) were produced to make WPC80 and SPC80, respectively. The 6 treatments, replicated 3 times each, that constituted the 18 processing runs within either whey or MF permeate UF were as follows: (1) no annatto; (2) no annatto+benzoyl peroxide (BPO); (3) no annatto+hydrogen peroxide (H2O2); (4) annatto; (5) annatto+BPO; and (6) annatto+H2O2. Approximately 700 kg of whey or 530 kg of MF permeate from each treatment were heated to 50°C and processed in 2 stages (UF and DF) with the UF system in batch recirculation mode using a polyethersulfone spiral-wound UF membrane with a molecular weight cutoff of 10,000 Da. Addition of annatto color had no effect on UF or DF flux. The processes of bleaching whey or MF permeate with or without added color improved flux during processing. Bleaching with H2O2 usually produced higher flux than bleaching with BPO. Bleaching with BPO increased WPC80 flux to a greater extent than it did SPC80 flux. Though no differences in mean flux were observed for a common bleaching treatment between the WPC80 and SPC80 production processes during the UF stage, mean flux during WPC80 DF was higher than mean flux during SPC80 DF for each bleaching treatment. Water flux values before and after processing were used to calculate a fouling coefficient that demonstrated differences in fouling which were consistent with flux differences among treatments. In both processes, bleaching with H2O2 led to the largest reduction in fouling. No effect of annatto on fouling was observed. The

  14. Old age and poverty

    Directory of Open Access Journals (Sweden)

    Vuković Drenka

    2010-01-01

    Full Text Available The process of demographic changes in Serbia is followed by discussions on the need to provide safety at old age and solve the problems of poverty and social exclusion of older citizens. In the current state there are no mechanisms that guarantee an adequate life standard at old age, the consequence of which is a high poverty rate, deteriorating health and limited access to social programs. The results of the Survey on life standard from 2002 and 2007 show that poverty among population in general and pensioners has decreased, while the poverty risk among people older than 65 has increased twice. The restrictive methods of the reforms cause a change in the relation between the pensions and the earnings, so that more and more pensioners receive below average, i.e. minimal pensions. Not all old people are covered by pension insurance so that a significant number (around 400.000 does not have a safe monthly income at all. The state program of financial aid is of modest size and does not provide help to all of the poor. Welfare aid decreases the risk of poverty, but it do not guarantee an adequate level of material security at old age. The low level of minimal and average pensions, the decline of participation in the average earnings and the strict criteria of the social security system have brought to awareness the necessity of 'social pensions' and various help and support programs for the elderly. .

  15. Endodontics and the ageing patient.

    Science.gov (United States)

    Johnstone, M; Parashos, P

    2015-03-01

    Patients are living longer and the rate of edentulism is decreasing. Endodontic treatment is an essential part of maintaining the health and well-being of the elderly. Retention of natural teeth improves the quality of life and the overall health and longevity of ageing patients. Also, teeth that might be otherwise extracted may be strategically valuable to retain a prosthesis, and elderly patients are more likely to have medical complications that may prevent dental extractions from being safely performed. The technical goals of endodontic treatment in the elderly are the same as those for younger patients. However, the pulpo-dentinal complex undergoes calcific changes over time, which may pose challenges for the clinician. The purposes of this review are to discuss age changes in the pulp and the challenges posed by diagnosing, treatment planning and treating the elderly endodontic patient.

  16. Cognitive Reserve Scale and ageing

    Directory of Open Access Journals (Sweden)

    Irene León

    2016-01-01

    Full Text Available The construct of cognitive reserve attempts to explain why some individuals with brain impairment, and some people during normal ageing, can solve cognitive tasks better than expected. This study aimed to estimate cognitive reserve in a healthy sample of people aged 65 years and over, with special attention to its influence on cognitive performance. For this purpose, it used the Cognitive Reserve Scale (CRS and a neuropsychological battery that included tests of attention and memory. The results revealed that women obtained higher total CRS raw scores than men. Moreover, the CRS predicted the learning curve, short-term and long-term memory, but not attentional and working memory performance. Thus, the CRS offers a new proxy of cognitive reserve based on cognitively stimulating activities performed by healthy elderly people. Following an active lifestyle throughout life was associated with better intellectual performance and positive effects on relevant aspects of quality of life.

  17. Lamin A, farnesylation and aging

    Energy Technology Data Exchange (ETDEWEB)

    Reddy, Sita [Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033 (United States); Comai, Lucio, E-mail: comai@usc.edu [Department of Molecular Microbiology and Immunology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033 (United States)

    2012-01-01

    Lamin A is a component of the nuclear envelope that is synthesized as a precursor prelamin A molecule and then processed into mature lamin A through sequential steps of posttranslational modifications and proteolytic cleavages. Remarkably, over 400 distinct point mutations have been so far identified throughout the LMNA gene, which result in the development of at least ten distinct human disorders, collectively known as laminopathies, among which is the premature aging disease Hutchinson-Gilford progeria syndrome (HGPS). The majority of HGPS cases are associated with a single point mutation in the LMNA gene that causes the production of a permanently farnesylated mutant lamin A protein termed progerin. The mechanism by which progerin leads to premature aging and the classical HGPS disease phenotype as well as the relationship between this disorder and the onset of analogous symptoms during the lifespan of a normal individual are not well understood. Yet, recent studies have provided critical insights on the cellular processes that are affected by accumulation of progerin and have suggested that cellular alterations in the lamin A processing pathway leading to the accumulation of farnesylated prelamin A intermediates may play a role in the aging process in the general population. In this review we provide a short background on lamin A and its maturation pathway and discuss the current knowledge of how progerin or alterations in the prelamin A processing pathway are thought to influence cell function and contribute to human aging.

  18. Biology of cancer and aging.

    Science.gov (United States)

    Holmes, F F; Wilson, J; Blesch, K S; Kaesberg, P R; Miller, R; Sprott, R

    1991-12-01

    The greatest risk factor for cancer is aging. Human cancer incidence increases exponentially with advancing age. Cancer growth rate and potential for metastatic spread may be influenced by age-specific change in host response. Because cancer and aging are, thus, inextricably linked, the American Cancer Society should encourage submission of research proposals that address the mechanisms of aging and how aging alters cancer development.

  19. Blood rheology and aging

    OpenAIRE

    Oğuz K. Başkurt; Simmonds, Michael J. ; Meiselman, Herbert J.

    2013-01-01

    Journal of Geriatric Cardiology (2013) 10: 291301 ©2013 JGC All rights reserved; www.jgc301.com http://www.jgc301.com; | Journal of Geriatric Cardiology Review  Open Access  Blood rheology and aging Michael J. Simmonds1, Herbert J. Meiselman2, Oguz K. Baskurt3 1Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Gold Coast, QLD 4222, Australia 2Department of Physiology and Biophysics, Keck School of Medicine, University of S...

  20. Relationship between tooth loss and mortality in 80-year-old Japanese community-dwelling subjects

    Directory of Open Access Journals (Sweden)

    Torisu Takehiro

    2010-07-01

    Full Text Available Abstract Background Findings from several studies suggest associations between tooth loss and health outcomes, including malnutrition, poor quality of life, and mortality, in older individuals. However, limited information is available regarding whether those associations remain true in very elderly subjects after adequately considering confounding factors such as sex and smoking status. Herein, we determined whether the number of teeth in 80-year-old subjects is an independent predictor of mortality. Methods We initially contacted 1282 80-year-old community-dwelling individuals born in 1917, of whom 697 responded and participated in a baseline study, with follow-up examinations conducted 4 and 5.5 years later. Data from interviews and medical and oral examinations were obtained, and oral health was determined according to the number of teeth remaining in the oral cavity. Results A total of 108 and 157 subjects died in 4 years and 5.5 years, respectively, after the baseline study. Tooth loss was significantly associated with mortality at age 85.5, but not at age 84, after adjusting for potential confounders. When the analysis was stratified by sex, we found a stronger association in females in follow-up examinations conducted at both 4- and 5.5 years. On the other hand, the effect of tooth loss on mortality was not significantly different between smokers and non-smokers. Conclusion Tooth loss is a significant predictor of mortality independent of health factors, socio-economic status, and lifestyle in octogenarians, with a stronger association in females.

  1. Aging in chalcohalide glasses: Origin and consequences

    DEFF Research Database (Denmark)

    Jensen, Martin; Smedskjær, Morten Mattrup; Wang, W.;

    2012-01-01

    The application of chalcogenide and chalcohalide glasses is limited by their uncontrolled drift in properties over time due to aging processes. In the present work, we perform aging experiments on some chalcohalide glasses in oxidizing, inert and reducing atmospheres and afterwards we measure the...

  2. Composition and structure of the 80S ribosome from the green alga Chlamydomonas reinhardtii: 80S ribosomes are conserved in plants and animals.

    Science.gov (United States)

    Manuell, Andrea L; Yamaguchi, Kenichi; Haynes, Paul A; Milligan, Ronald A; Mayfield, Stephen P

    2005-08-12

    We have conducted a proteomic analysis of the 80S cytosolic ribosome from the eukaryotic green alga Chlamydomonas reinhardtii, and accompany this with a cryo-electron microscopy structure of the ribosome. Proteins homologous to all but one rat 40S subunit protein, including a homolog of RACK1, and all but three rat 60S subunit proteins were identified as components of the C. reinhardtii ribosome. Expressed Sequence Tag (EST) evidence and annotation of the completed C. reinhardtii genome identified genes for each of the four proteins not identified by proteomic analysis, showing that algae potentially have a complete set of orthologs to mammalian 80S ribosomal proteins. Presented at 25A, the algal 80S ribosome is very similar in structure to the yeast 80S ribosome, with only minor distinguishable differences. These data show that, although separated by billions of years of evolution, cytosolic ribosomes from photosynthetic organisms are highly conserved with their yeast and animal counterparts.

  3. First measurements of reactive α-dicarbonyl concentrations on PM2.5 aerosol over the boreal forest in Finland during HUMPPA-COPEC 2010 – source apportionment and links to aerosol aging

    Directory of Open Access Journals (Sweden)

    T. Petäjä

    2012-01-01

    Full Text Available The first dataset for summertime boreal forest concentrations of two atmospherically relevant α-dicarbonyl compounds, glyoxal (Gly and methylglyoxal (Mgly on PM2.5 aerosol was obtained during the HUMPPA-COPEC-2010 field measurement intensive in Hyytiälä, Finland. Identification of anthropogenic influences over the course of the campaign, using trace gas signatures and aerosol particle chemical composition analysis, allowed the identification of different events such as urban pollution plumes, biomass burning and sawmill emissions as sources of high Gly and Mgly concentrations. Mean aerosol concentrations during periods of biogenic influence were 0.81 ng m−3 for Gly and 0.31 ng m−3 for Mgly. Mgly was generally less abundant in PM2.5, probably due to its shorter photolysis lifetime and less effective partitioning into the particle phase due to its smaller effective Henry's Law constant compared to Gly. This is in contrast with previous urban studies which show significantly more Mgly than Gly. Peak concentrations for Gly coincided with nearby sources, e.g. high VOC emissions from nearby sawmills, urban pollution plumes from the city of Tampere located 50 km southwest of the sampling site and biomass burning emissions from wildfires. Calculated ratios of Gly in PM2.5 and total organic matter in PM1 aerosols indicate higher values in less aged aerosols. Irreversible processing of Gly in the particle phase, e.g. via oxidation by OH radicals, organo sulfate or imidazole formation are processes currently discussed in the literature which could likely explain these findings.

  4. Aging, immunity, and cancer.

    Science.gov (United States)

    Fulop, Tamas; Larbi, Anis; Kotb, Rami; de Angelis, Flavia; Pawelec, Graham

    2011-06-01

    Age is the most important risk factor for tumorigenesis. More than 60% of new cancers and more than 70% of cancer deaths occur in elderly subjects >65 years. The immune system plays an important role in the battle of the host against cancer development. Deleterious alterations occur to the immune response with aging, termed immunosenescence. It is tempting to speculate that this waning immune response contributes to the higher incidence of cancer, but robust data on this important topic are few and far between. This review is devoted to discussing state of the art knowledge on the relationship between immunosenescence and cancer. Emerging understanding of the aging process at the molecular level is viewed from the perspective of this increased tumorigenesis. We also consider some of the most recent means to intervene in the modulation of immunosenescence to increase the ability of the immune system to fight against tumors. Future research will unravel new aspects of the immune response against tumors which will be modulable to decrease the burden of cancer in elderly individuals.

  5. Thresholds for Fatigue Initiation and Propagation and Plastic Work in HY80 and HY130 Steels.

    Science.gov (United States)

    1980-10-16

    MNl/en for HY80 and 3.8 MN/m2 for HY130 (R = 0.05) seemed low compared to some other published values for steels .6 It was, therefore, decided to...Macrocrack Growth in Tempered HY80 , HY130, and 4140 Steels : Threshold and Mid-AK Range", submitted to Fatigue of Engineering Materials and Structures...Assistant 9/79 to present. PUBLICATIONS 1. S. I. Kwun and M. E. Fine, "Fatigue Macrocrack Growth in Tempered HY80 , HYI30, and 4140 Steels : Threshold and

  6. 老年听力障碍量表筛查版与完整版结果对比分析%Comparison of HHIE and HHIE-s Results in People over 70 Years of Age

    Institute of Scientific and Technical Information of China (English)

    韩莹; 周其友; 冀飞

    2014-01-01

    Objective To compare the results between Hearing Handicap Inventory for the Elderly (HHIE) and its screening version (HHIE-S) in elderly people over 70 years of age with hearing handicap. Methods One hundred and twenty people over 70 years participated in the survey using HHIE or HHIE-S respectively. Hearing function handicap scores from HHIE and HHIE-S were compared. Results HHIE scores identified 41 subjects with hearing function handicap (mild-to-mod-erate in 24 and maximum in 17). In comparison, HHIE-S identified 39 subjects with hearing function handicap (mild-to-mod-erate in 27 and maximum in 12). No significant difference was found between the results from HHIE and HHIE-S (X2=1.064, P=0.588). Conclusion HHIE-S can be used as a convenient screening tool in investigating hearing handicap in elderly peo-ple, with similar validity as HHIE.%目的:对比老年听力障碍量表完整版(HHIE)与筛查版(HHIE-S)调查问卷结果,探讨更便捷的功能性听力障碍筛检方法。方法对120例70岁以上老年人分别进行老年听力障碍量表HHIE和HHIE-S的问卷调查,对比各自听力障碍分级标准,分别得出听力障碍等级结论。将HHIE结果与HHIE-S结果进行比较。结果根据HHIE功能性听力障碍分级标准,完整版有41例存在听力障碍,其中轻中度24例,重度17例。HHIE-S结果显示39例存在听力障碍,其中轻中度27例,重度12例。HHIE和HHIE-S的功能性听力障碍分级结果无统计学差异(X2=1.064, P=0.588)。结论老年听力障碍量表筛查版(HHIE-S)可以代替完整版进行临床调查,更便于患者信息采集及临床应用。

  7. E-Learning and the Third Age

    Science.gov (United States)

    Trentin, Guglielmo

    2004-01-01

    As a result of the general improvement in living conditions in industrialised Western countries, people aged over 60 years usually reach the third age in good mental and physical condition. Contemporary society has thus had to endeavour to offer the new old not only social services but also pastimes, leisure, social, cultural and educational…

  8. The changing face of orthostatic and neurocardiogenic syncope with age.

    LENUS (Irish Health Repository)

    Cooke, J

    2012-01-31

    AIM: Reports of the outcomes of syncope assessment across a broad spectrum of ages in a single population are scarce. It is our objective to chart the varying prevalence of orthostatic and neurocardiogenic syncope (NCS) as a patient ages. METHODS: This was a retrospective study. All consecutive patients referred to a tertiary referral syncope unit over a decade were included. Patients were referred with recurrent falls or orthostatic intolerance. Tilt tests and carotid sinus massage (CSM) were performed in accordance with best practice guidelines. RESULTS: A total of 3002 patients were included (1451 short tilt, 127 active stand, 1042 CSM and 382 prolonged tilt). Ages ranged from 11 to 91 years with a median (IQR) of 75 (62-81) years. There were 1914 females; 1088 males. Orthostatic hypotension (OH) was the most commonly observed abnormality (test positivity of 60.3%). Those with OH had a median (IQR) age of 78 (71-83) years. Symptomatic patients were significantly younger than asymptomatic (P = 0.03). NCS demonstrated a bimodal age distribution. Of 194 patients with carotid sinus hypersensitivity, the median age (IQR) was 77 (68-82) years. Those with vasovagal syncope (n = 80) had a median (IQR) age of 30 (19-44) years. There were 57 patients with isolated postural orthostatic tachycardia syndrome. Of the total patients, 75% were female. They had a median (IQR) age of 23 (17-29) years. CONCLUSION: We have confirmed, in a single population, a changing pattern in the aetiology of syncope as a person ages. The burden of disease is greatest in the elderly.

  9. Effect of Pack Temperature on Microstructure and Properties of Aluminized N80 Oil Casing Steel%包埋温度对N80套管钢渗铝层微观结构及性能的影响

    Institute of Scientific and Technical Information of China (English)

    黄敏; 王宇

    2011-01-01

    The aluminizing layer was prepared on the surface of N80 oil easing steel by pack aluminizing processing at 950 ℃ and 1050 ℃. The effects of pack temperature on the microstructure, microhardness and electrochemical corrosion resistance of as-aluminized N80 oil casing steel were studied. The results show that the as-prepared aluminizing layer with thickness over 200μ m at 950℃ and 1050 ℃ exhibit higher microhardness and better corrosion resistance thanthat of non-aluminizing N80 oil casing steel. Although the thickness of aluminizing layer and microhardness of aluminized N80 oil casing steel can be obviously improved by increasing the pack temperature, the property of N80 oil casing steel substrate decreases at a very high pack temperature.%采用固体粉末包埋法对N80套管钢进行渗铝,形成富铝表层.研究了包埋温度为950、1050℃时所得渗铝N80套管钢的微观结构、硬度及电化学腐蚀特性.结果表明:不同包埋温度所得渗铝层厚度均超过200μm;渗铝N80套管钢在渗层深度范围内的硬度高于基体;渗铝后N80套管钢的耐腐蚀性得以提高.升高包埋温度可以显著提高所得渗铝层的厚度和硬度,但过高的包埋温度会同时造成基体性能更严重地下降.

  10. Structures similar to lipid emulsions and liposomes. Dipalmitoylphosphatidylcholine, cholesterol, Tween 20-Span 20 or Tween 80-Span 80 in aqueous media.

    Science.gov (United States)

    Juárez-Osornio, Carlos; Gracia-Fadrique, Jesús

    2017-06-01

    In the present work, we show that we obtained nanometric structures made of water, 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), cholesterol (Chol), and a mixture of ethoxylated and non-ethoxylated sorbitan fatty acid esters (Tween 20, Span 20, Tween 80, and Span 80) by mixing all of them near the cloud point temperature (cp) of the ethoxylated surfactant. The influence that the constituents had on the size of the particle was determined by a pseudo-ternary phase diagram of water/Tween-Span/DPPC-Chol; the colloidal particles obtained were studied by differential scanning calorimetry, confocal fluorescence microscopy, scanning electron microscopy, and atomic force microscopy. These studies were made for all the systems with at least 23 d of colloidal stability. The most stable system was obtained with the Tween 80-Span 80 pair, behaving as a typical suspension for 48 d; this system was made of water, Tween 80-Span 80 (80:20), DPPC-Chol (95:5) in a corresponding molar ratio of 48:37:100:10. The colloidal particles obtained were a kind of emulsion and liposome structures. The second stable system was obtained with the same mixture, but in a molar ratio of 8:6:9:0, its structure was also a kind of emulsion particles. In both systems and in other less stable ones, the "emulsion particle" was completely new, it structurally corresponds to a nucleus of mixed micelles surrounded by at least one bilayer of DPPC.

  11. Qos and Voice Over IP

    Directory of Open Access Journals (Sweden)

    Adrian GHENCEA

    Full Text Available As Voice over Internet Protocol (VoIP technology matures, companies are increasingly adopting it to cut costs, improve efficiency and enhance customer service. Using the Internet as an existing network for integrating data and telecom systems through intelligent VoIP, a range of benefits results: lower long distance costs, cost cuts in cabling processes and more flexible telephony management. However, as voice over IP services grow in popularity, major threats arise: this rapid growth leads to traffic congestion, security is jeopardizedand the poor quality of calls affects communication. The objective of this article is to present all the elements that can affect voicequality in a VoIP network and to provide methods for solving them. A detailed analysis to minimize the impact of implementation of QoS will be made, and at the end solutions to management strategies will be proposed.

  12. Neutron-Capture Kr-80 and Ar-36 in the Martian Atmosphere and Regolith

    Science.gov (United States)

    Rao, M. N.; Bogard, D. D.; Nyquist, L.; McKay, D. S.; Masarik, J.

    2001-01-01

    We calculate that approximately 10% of martian atmospheric Kr-80 formed by neutron capture on Mars in approx. 0.5 Ga. The regolith contains even larger amounts of n-capture Kr-80 and Ar-36, which may provide clues to the evolution of the martian regolith and atmosphere. Additional information is contained in the original extended abstract.

  13. Production and Drawing of 80 Steel Wire Rod%80钢盘条的生产与拉拔

    Institute of Scientific and Technical Information of China (English)

    马志军; 周桂兰; 曹二转; 张全刚; 琚艳军

    2006-01-01

    介绍高强度80钢盘条的生产工艺流程和力学性能指标,通过金相组织分析,指出钢的组织中出现网状渗碳体是拉拔断裂的主要原因,采用人工时效并改进拉拔工艺,使各道次的压缩率均匀合理,在一定程度上可以弥补组织不当带来的缺陷,有利于盘条的拉拔.

  14. Ageing and digital games

    DEFF Research Database (Denmark)

    Iversen, Sara Mosberg

    2016-01-01

    Digital games are still to a great degree considered a medium mainly for young boys. However, available statistics on Western media use show that this is far from the case. Increasingly, people of all ages and genders play digital games, also older adults in their early 60s and beyond. The aim...... of the book is to examine, analyse and discuss: 1) What older adults do with digital games and what meanings the use of digital games take on in the everyday life of older adults; 2) How older adults are perceived by society in relation to digital games; 3) How play and games can be used both...

  15. Ages and Stages: Teen

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Ages & Stages Prenatal Baby Toddler Preschool Gradeschool Teen Dating & ... Safety School Substance Abuse Young Adult Healthy Children > Ages & Stages > Teen Teen Article Body Adolescence can be ...

  16. Successful Aging and Longevity in Older Old Women: The Role of Depression and Cognition

    Directory of Open Access Journals (Sweden)

    Daniel Paulson

    2011-01-01

    Full Text Available Based in successful aging theory and terminal cognitive drop research, this paper investigates cerebrovascular burden (CVB, depressive symptoms, and cognitive decline as threats to longevity. A subsample of stroke-free women over the age of 80 was identified in the Health and Retirement Survey (years 2000–2008. Mortality at 2, 6, and 8 year intervals was predicted using CVB (diabetes, heart disease, hypertension, depressive symptoms (Center for Epidemiological Studies Depression Scale, and cognitive decline (decline of 1 standard deviation or more on the 35-point Telephone Interview for Cognitive Status over 2 years. At most waves (2002, 2004, and 2006 mortality was predicted by CVB, depressive symptoms, and cognitive drop measured 2 years prior. CVB and depressive symptoms at the 2000 wave predicted mortality at 6 and 8 years. Older women with the greatest longevity had low CVB, robust cognitive functioning, and few depression symptoms, supporting successful aging theory and terminal cognitive drop.

  17. Ageing and cell-mediated immunity.

    Science.gov (United States)

    Fixa, B; Komárková, O; Chmelar, V

    1975-01-01

    The lymphocyte transformation test with phytohemagglutinin as mitogen estimated according to the incorporation of 2-(14)C-thymidine in DNA was used as an indicator of cell-mediated reactivity in 53 healthy subjects. Three age groups were examined: up to 20 years (21 subjects), 21-40 years (10 subjects) and over 70 years (22 subjects). The responsiveness of lymphocytes decreased significantly with age. In the highest age group 12 pathologically low values were found.

  18. Influence of selected demographic factors on traumas in persons over 65 years of age reporting to the Hospital Medical Ward

    Directory of Open Access Journals (Sweden)

    Mateusz Andrzej Pytlak

    2016-02-01

    Full Text Available Background. Falls and traumas in elderly persons don’t only result in health problems, but they also involve social and economic, psychological and political consequences. The most frequent trauma mechanisms in the elderly include: falls and traffic accidents. ;b:Objectives. The aim of the study was to assess selected factors influencing the energy, type and area of a trauma incurred by elderly people. Material and methods. A group of 108 patients aged 65–93 treated at the SPSK 1 in Szczecin were tested by a diagnostic survey with the use of a questionnaire. The eligibility criteria included a trauma as a result of an accident, the age of the subject above 65 years of age and expressing written, voluntary and informed consent to participation in the study. Results. 177 traumas were recorded in the analysed group of 108 patients. The most frequent traumas included fractures and contusions and the lower limbs and the left arm were the most frequently injured body parts. Men were more often injured during low-energy events. Patients more often had their upper body and left leg injured during low-energy events than during high-energy ones. In persons over 65 years of age, usually one fracture occurred during a low-energy accident. Conclusions. The most common result of injuries among people aged 65+ admitted to the emergency department are fractures. With age the number of LE T increases and the number of HET decreases. It’s necessary therefore to create an appropriate health policy covering education for elderly people and their families to prevent injuries of low energy content.

  19. Effects of rhythmic exercise performed to music on the rheological properties of blood in women over 60 years of age.

    Science.gov (United States)

    Marchewka, Anna; Filar-Mierzwa, Katarzyna; Dąbrowski, Zbigniew; Teległó, Aneta

    2015-01-01

    The aim of this study was to analyze the effects of motor rehabilitation, in the form of rhythmic exercise to music, on the rheological characteristics of blood in older women. The study included 30 women (65-80 years of age), and the control group was comprised of 10 women of corresponding age. Women from the experimental group were subjected to a five-month rehabilitation program, in the form of rhythmic exercise performed to music (three 30-minute sessions per week); women from the control group were not involved in any regular physical activity. Blood samples from all the women were examined for hematological, rheological, and biochemical parameters prior to the study and five months thereafter. The rehabilitation program was reflected by a significant improvement of erythrocyte count and hematocrit. Furthermore, an improvement of erythrocyte deformability was observed by lower shear stress levels, while no significant changes were noted by the higher shear stress values. The rehabilitation resulted in a marked decrease of the aggregation amplitude while no significant changes were observed in aggregation index and total aggregation half-time. Additionally, the training regimen was reflected by a significant increase in the plasma viscosity, while no significant changes in fibrinogen levels were noted.

  20. Statin prescribing according to gender, age and indication

    DEFF Research Database (Denmark)

    Wallach-Kildemoes, Helle; Støvring, Henrik; Holme Hansen, Ebba

    2016-01-01

    RATIONALES, AIMS AND OBJECTIVES: The increasing dispensing of statins has raised concern about the appropriateness of prescribing to various population groups. We aimed to (1) investigate incident and prevalent statin prescribing according to indication, gender and age and (2) relate prescribing...... numbers of statin users according to register proxies for indication, gender and age. RESULTS: In 2010, the prevalence became highest for ages 75-84 and was higher in men than women (37% and 33%, respectively). Indication-specific incidences and prevalences peaked at ages around 65-70, but in myocardial...... infarction, the prevalence was about 80% at ages 45-80. Particularly, incidences tended to be lower in women until ages of about 60 where after gender differences were negligible. In asymptomatic individuals (hypercholesterolaemia, presumably only indication) aged 50+, dispensing was highest in women...

  1. Microstructures and mechanical properties of AZ80 alloy treated by pulsed ultrasonic vibration

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Pulsed ultrasonic field was employed in the melt of the AZ80 magnesium alloy. The effects of pulsed ultrasonic field on mierostructure and mechanical properties of AZ80 magnesium alloy were investigated. The results show that the as-cast mierostructure of the AZ80 alloy with pulsed ultrasonic treatment is significantly changed. Pulsed ultrasonic field significantly decreases the grain size, changes the morphologies of the β-Mg17Al12 phases and reduces their area fraction. It is found that pulse width of ultrasonic plays an important role on the microstrueture formation of AZ80 alloy. With increasing pulse width, grains beeome finer and more uniform. In the range of experimental parameters, the optimum pulse width for melt treatment process is found to be 210 μs. The mechanical tests show that the mechanical properties of the as-cast AZ80 magnesium alloy with pulsed ultrasonic treatment are much higher than those of AZ80 alloy without ultrasonic field.

  2. Autophagy in ageing and ageing-associated diseases

    Institute of Scientific and Technical Information of China (English)

    Li-qiang HE; Jia-hong LU; Zhen-yu YUE

    2013-01-01

    Autophagy is a cell self-digestion process via lysosomes that clears "cellular waste",including aberrantly modified proteins or protein aggregates and damaged organelles.Therefore,autophagy is considered a protein and organelle quality con