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Sample records for age experimental analysis

  1. Mathematical Modelling and Experimental Analysis of Early Age Concrete

    DEFF Research Database (Denmark)

    Hauggaard-Nielsen, Anders Boe

    1997-01-01

    lead to cracks in the later cooling phase. The matrial model has intrigate couplings between the involved mechanics, and in the thesis special emphasize is put on the creep behaviour. The mathematical models are based on experimental analysis and numerical implementation of the models in a finite...

  2. Aging in biometrics: an experimental analysis on on-line signature.

    Directory of Open Access Journals (Sweden)

    Javier Galbally

    Full Text Available The first consistent and reproducible evaluation of the effect of aging on dynamic signature is reported. Experiments are carried out on a database generated from two previous datasets which were acquired, under very similar conditions, in 6 sessions distributed in a 15-month time span. Three different systems, representing the current most popular approaches in signature recognition, are used in the experiments, proving the degradation suffered by this trait with the passing of time. Several template update strategies are also studied as possible measures to reduce the impact of aging on the system's performance. Different results regarding the way in which signatures tend to change with time, and their most and least stable features, are also given.

  3. Effect of cholecystokinin on experimental neuronal aging

    Institute of Scientific and Technical Information of China (English)

    Xiao-Jiang Sun; Qin-Chi Lu; Yan Cai

    2005-01-01

    AIM: To observe the effect of cholecystokinin (CCK) on lipofusin value, neuronal dendrite and spine ultrastructure, and total cellular protein during the process of experimental neuronal aging.METHODS: Experimental neuronal aging study model was established by NBA2cellular serum-free culture method. By using single irtracellular lipofusin value from microspectrophotometry,morphology of neuronal dendrites and spines from the scanner electron microscopy, and total cellular protein as the indexes of experimental neuronal aging, we observed the effect of CCK8 on the process of experimental neuronal aging.RESULTS: Under the condition of serum-free culture,intracellular fluorescence value (%) increased with the extension of culture time (1 d 8.51±3.43; 5 d 10.12±3.03;10 d 20.54±10.3; 15 d 36.88±10.49; bP<0.01). When CCK was added to serum-free culture medium, intracellular lipofusin value (%) decreased remarkably after consecutive CCK reaction for 10 and 15 d (control 36.88±10.49; 5 d 32.03±10.01; 10 d 14.37±5.55; 15 d 17.31±4.80; bP<0.01).As the time of serum-free culturing was prolonged, the number of neuronal dendrite and spine cells decreased.The later increased in number when CCK8 was added. CCK8 could improve the total cellular protein in the process of experimental neuronal aging.CONCLUSION: CCK8 may prolong the process of experimental neuronal aging by maintaining the structure and the number of neuronal dendrite and spine cells and changing the total cellular protein.

  4. Experimental evolution of aging in a bacterium

    Directory of Open Access Journals (Sweden)

    Stearns Stephen C

    2007-07-01

    Full Text Available Abstract Background Aging refers to a decline in reproduction and survival with increasing age. According to evolutionary theory, aging evolves because selection late in life is weak and mutations exist whose deleterious effects manifest only late in life. Whether the assumptions behind this theory are fulfilled in all organisms, and whether all organisms age, has not been clear. We tested the generality of this theory by experimental evolution with Caulobacter crescentus, a bacterium whose asymmetric division allows mother and daughter to be distinguished. Results We evolved three populations for 2000 generations in the laboratory under conditions where selection was strong early in life, but very weak later in life. All populations evolved faster growth rates, mostly by decreasing the age at first division. Evolutionary changes in aging were inconsistent. The predominant response was the unexpected evolution of slower aging, revealing the limits of theoretical predictions if mutations have unanticipated phenotypic effects. However, we also observed the spread of a mutation causing earlier aging of mothers whose negative effect was reset in the daughters. Conclusion Our results confirm that late-acting deleterious mutations do occur in bacteria and that they can invade populations when selection late in life is weak. They suggest that very few organisms – perhaps none- can avoid the accumulation of such mutations over evolutionary time, and thus that aging is probably a fundamental property of all cellular organisms.

  5. Experimental Researches of Blood Stasis and Aging

    Institute of Scientific and Technical Information of China (English)

    王传社; 李顺成; 马治中; 李志新; 蒋文跃

    2001-01-01

    @@It was reported by most physicians of traditional Chinese medicine (TCM) in past dynasties that Deficiency of Zangfu(脏腑), Qi and blood, especially the Kidney deficiency, is closely related with aging, and Chinese drugs for fortifying Kidney also play a main role in anti-aging. Many scholars have recently studied the relationship between aging and the Excess Syndrome, such as blood stasis, stagnation of Phlegm Turbidity and stagnation of Qi, particularly the relationship between blood stasis and aging.

  6. Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention.

    Science.gov (United States)

    Brioche, Thomas; Pagano, Allan F; Py, Guillaume; Chopard, Angèle

    2016-08-01

    Identification of cost-effective interventions to maintain muscle mass, muscle strength, and physical performance during muscle wasting and aging is an important public health challenge. It requires understanding of the cellular and molecular mechanisms involved. Muscle-deconditioning processes have been deciphered by means of several experimental models, bringing together the opportunities to devise comprehensive analysis of muscle wasting. Studies have increasingly recognized the importance of fatty infiltrations or intermuscular adipose tissue for the age-mediated loss of skeletal-muscle function and emphasized that this new important factor is closely linked to inactivity. The present review aims to address three main points. We first mainly focus on available experimental models involving cell, animal, or human experiments on muscle wasting. We next point out the role of intermuscular adipose tissue in muscle wasting and aging and try to highlight new findings concerning aging and muscle-resident mesenchymal stem cells called fibro/adipogenic progenitors by linking some cellular players implicated in both FAP fate modulation and advancing age. In the last part, we review the main data on the efficiency and molecular and cellular mechanisms by which exercise, replacement hormone therapies, and β-hydroxy-β-methylbutyrate prevent muscle wasting and sarcopenia. Finally, we will discuss a potential therapeutic target of sarcopenia: glucose 6-phosphate dehydrogenase. PMID:27106402

  7. Experimental Researches of Blood Stasis and Aging

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    It was reported by most physicians of traditional Chinese medicine (TCM) in past dynasties that Deficiency of Zangfu(脏腑), Qi and blood, especially the Kidney deficiency, is closely related with aging, and Chinese drugs for fortifying Kidney also play a main role in anti-aging. Many scholars have recently studied the relationship between aging and the Excess Syndrome, such as blood stasis, stagnation of Phlegm Turbidity and stagnation of Qi, particularly the relationship between blood stasis and aging.……

  8. Age, Women, and Hiring: An Experimental Study

    Science.gov (United States)

    Lahey, Joanna N.

    2008-01-01

    As baby boomers reach retirement age, demographic pressures on public programs may cause policy makers to cut benefits and encourage employment at later ages. But how much demand exists for older workers? This paper reports on a field experiment to determine hiring conditions for older women in entry-level jobs in two cities. A younger worker is…

  9. Lithuanian Population Aging Factors Analysis

    OpenAIRE

    Agnė Garlauskaitė; Rasa Zabarauskaitė

    2015-01-01

    The aim of this article is to identify the factors that determine aging of Lithuania’s population and to assess the influence of these factors. The article shows Lithuanian population aging factors analysis, which consists of two main parts: the first describes the aging of the population and its characteristics in theoretical terms. Second part is dedicated to the assessment of trends that influence the aging population and demographic factors and also to analyse the determinants of the agin...

  10. An Experimental Analysis

    OpenAIRE

    Maciejovsky, Boris; Kirchler, Erich; Schwarzenberger, Herbert

    2001-01-01

    We investigate (i) whether traders on an experimental asset market form different and separate mental accounts for sale revenues and for dividend earnings and whether (ii) an increase in tax penalty or (iii) an increase in audit frequency increases tax compliance. The results indicate that participants did not form separate mental accounts for sale revenues and for dividend earnings. However in line with prospect theory, it can be shown that a purchase of assets is perceived as a subjective l...

  11. Bayesian Analysis of Experimental Data

    Directory of Open Access Journals (Sweden)

    Lalmohan Bhar

    2013-10-01

    Full Text Available Analysis of experimental data from Bayesian point of view has been considered. Appropriate methodology has been developed for application into designed experiments. Normal-Gamma distribution has been considered for prior distribution. Developed methodology has been applied to real experimental data taken from long term fertilizer experiments.

  12. TFTR experimental data analysis collaboration

    International Nuclear Information System (INIS)

    The research performed under the initial year of this grant has concentrated on a few key TFTR experimental data analysis issues: MHD effects on supershots; poloidal asymmetry effects in beam-heated plasmas; and analysis of transport processes in perturbed plasmas. Progress in these areas and activities undertaken in conjunction with this grant are summarized briefly in this report

  13. Experimental design of natural and accellerated bone and wood ageing

    DEFF Research Database (Denmark)

    Facorellis, Y.; Pournou, A.; Richter, Jane;

    2015-01-01

    This paper presents the experimental design for natural and accelerated ageing of bone and wood samples found in museum conditions that was conceived as part of the INVENVORG (Thales Research Funding Program – NRSF) investigating the effects of the environmental factors on natural organic materials....

  14. Experimental investigation of cyclic hygrothermal aging of hybrid composite

    KAUST Repository

    El Yagoubi, Jalal

    2013-04-05

    This work provides an experimental investigation of the cyclic hygrothermal aging of a hybrid composites. We aimed to propose a general framework in the view to further optimize polymer-based composites. It reports experimental data and relevant observations collected during an aging campaign (up to 2000 cycles) where anhydride-cured epoxy samples as well as composites samples are exposed to environmental conditions. The data gathered during the whole campaign reveals that (1) the polymer displays a non-classical sorption behavior (2) the volume change is correlated to the mass uptake (3) the elastic modulus is correlated to the glass transition temperature. Matrix and interface degradation of the hybrid composite is monitored by means of microstructural observations. © 2013 by the American Institute of Aeronautics and Astronautics, Inc. All rights reserved.

  15. Aging and demographic plasticity in response to experimental age structures in honeybees (Apis mellifera L).

    Science.gov (United States)

    Rueppell, Olav; Linford, Robyn; Gardner, Preston; Coleman, Jennifer; Fine, Kari

    2008-08-01

    Honeybee colonies are highly integrated functional units characterized by a pronounced division of labor. Division of labor among workers is mainly age-based, with younger individuals focusing on in-hive tasks and older workers performing the more hazardous foraging activities. Thus, experimental disruption of the age composition of the worker hive population is expected to have profound consequences for colony function. Adaptive demography theory predicts that the natural hive age composition represents a colony-level adaptation and thus results in optimal hive performance. Alternatively, the hive age composition may be an epiphenomenon, resulting from individual life history optimization. We addressed these predictions by comparing individual worker longevity and brood production in hives that were composed of a single age cohort, two distinct age cohorts, and hives that had a continuous, natural age distribution. Four experimental replicates showed that colonies with a natural age composition did not consistently have a higher life expectancy and/or brood production than the single cohort or double cohort hives. Instead, a complex interplay of age structure, environmental conditions, colony size, brood production, and individual mortality emerged. A general trade-off between worker life expectancy and colony productivity was apparent, and the transition from in-hive tasks to foraging was the most significant predictor of worker lifespan irrespective of the colony age structure. We conclude that the natural age structure of honeybee hives is not a colony-level adaptation. Furthermore, our results show that honeybees exhibit pronounced demographic plasticity in addition to behavioral plasticity to react to demographic disturbances of their societies.

  16. Experimental strategies for frost analysis

    Science.gov (United States)

    Janssen, Daniel D.

    An area of increasing importance in the field of refrigeration is the study of frosting and defrosting. Frosting poses a concern to many refrigeration systems, as frost growth both obstructs airflow through low temperature heat exchangers and increases heat transfer resistance. Drastic decreases in system efficiency result from the compounding of these problems, and because it is difficult to prevent the frosting process, refrigeration systems must be defrosted periodically to restore optimal operating conditions. A deeper understanding of the complex physical processes of frosting and defrosting will lead to more efficient refrigeration system designs; an idea which has driven a rise in frost growth research over recent decades. Although research has shown great progress, there remain significant challenges associated with predicting the frosting and defrosting processes accurately under wide ranges of conditions. The equations governing such behavior still remain insoluble by exact analytical methods. Numerical approaches have shown the most promising results, but are yet in an early stage of development. Most research has instead been concerned with developing correlations for frost properties and growth, though few are applicable to varying conditions. The most commonly used correlations are shown to have widely different results, perhaps owing to different experimental methods used to acquire data and a lack of deeper level analysis. A new thickness correlation is proposed which attempts to reconcile to some degree the gap between theory and application. Broader ranges of data are used for fitment which enables the application of the correlation to a wider range of conditions. To improve the consistency of results in frost research, it is suggested that new forms of data acquisition be explored. Proposed alternative methods utilize high magnification imaging equipment in combination with computer based measurements, which are shown to be capable of improving

  17. Survival analysis of aging aircraft

    Science.gov (United States)

    Benavides, Samuel

    This study pushes systems engineering of aging aircraft beyond the boundaries of empirical and deterministic modeling by making a sharp break with the traditional laboratory-derived corrosion prediction algorithms that have shrouded real-world failures of aircraft structure. At the heart of this problem is the aeronautical industry's inability to be forthcoming in an accurate model that predicts corrosion failures in aircraft in spite of advances in corrosion algorithms or improvements in simulation and modeling. The struggle to develop accurate corrosion probabilistic models stems from a multitude of real-world interacting variables that synergistically influence corrosion in convoluted and complex ways. This dissertation, in essence, offers a statistical framework for the analysis of structural airframe corrosion failure by utilizing real-world data while considering the effects of interacting corrosion variables. This study injects realism into corrosion failures of aging aircraft systems by accomplishing four major goals related to the conceptual and methodological framework of corrosion modeling. First, this work connects corrosion modeling from the traditional, laboratory derived algorithms to corrosion failures in actual operating aircraft. This work augments physics-based modeling by examining the many confounding and interacting variables, such as environmental, geographical and operational, that impact failure of airframe structure. Examined through the lens of censored failure data from aircraft flying in a maritime environment, this study enhances the understanding between the triad of the theoretical, laboratory and real-world corrosion. Secondly, this study explores the importation and successful application of an advanced biomedical statistical tool---survival analysis---to model censored corrosion failure data. This well-grounded statistical methodology is inverted from a methodology that analyzes survival to one that examines failures. Third, this

  18. Functional recovery in aging mice after experimental stroke.

    Science.gov (United States)

    Manwani, Bharti; Liu, Fudong; Xu, Yan; Persky, Rebecca; Li, Jun; McCullough, Louise D

    2011-11-01

    Aging is a non-modifiable risk factor for stroke. Since not all strokes can be prevented, a major emerging area of research is the development of effective strategies to enhance functional recovery after stroke. However, in the vast majority of pre-clinical stroke studies, the behavioral tests used to assess functional recovery have only been validated for use in young animals, or are designed for rats. Mice are increasingly utilized in stroke models but well validated behavioral tests designed for rats are not necessarily reproducible in mice. We examined a battery of behavioral tests to evaluate functional recovery in an aging murine model of stroke. We found that the vertical pole, hanging wire and open field can accurately assess acute behavioral impairments after stroke in both young and aging male mice, but animals recover rapidly on these tasks. The corner test can accurately and repeatedly differentiate stroke from sham animals up to 30 days post stroke and can be performed reliably in aging mice. Aging male mice had significantly worse behavioral impairment compared to young male mice in the first two weeks after stroke but eventually recovered to the same degree as young mice. In contrast, chronic infarct size, as measured by ipsilateral cerebral atrophy, was significantly lower in aging male mice compared to young male mice. Reactive gliosis, formation of glial scar, and an enhanced innate immune response was seen in the aging brain and may contribute to the delayed behavioral recovery seen in the aging animals.

  19. Experimental and computational study on microstructural evolution in 2205 duplex stainless steel during high temperature aging

    International Nuclear Information System (INIS)

    Research highlights: → σ is the first phase to appear at higher temperature because of rapid growth rate. → Thermodynamic driving force for χ phase is always larger than that for σ phase. → The kinetic calculation on the migration of γ/α interface during aging is present. - Abstract: 2205 duplex stainless steel (DSS) aged at temperatures between 700 deg. C and 1050 deg. C for different time intervals (5 min, 0.5 h, 1 h, 2 h) is studied. The evolution of secondary phases and the matrix with variation of aging time and temperature are measured by means of optical metallography (OM), SEM and EDS and BSE. The impact toughness, which reflects the effects of secondary phases, is also measured. It is shown that σ is the dominant secondary phase in the matrix. The σ phase precipitates at the austenite/ferrite boundaries or within ferritic grains, with the volume percent increasing with aging time and maximizing at 850 deg. C. Aided by Thermo-Calc software, the thermodynamic driving forces for χ phase and σ phase are calculated. Although the driving force for χ phase is larger than that for σ phase between 700 deg. C and 900 deg. C, σ phase appears before χ phase because of its rapid growth rate at higher aging temperatures. According to the OM analysis and thermodynamic calculations, 2205 DSS at aging temperatures above 1000 deg. C is composed of ferrite and austenite, its volume fraction of ferrite increases with the increase of aging temperature. Moreover, the kinetic calculation on the migration of austenite/ferrite interface after different aging time is present. The thermodynamic and kinetic calculation results on the microstructural evolution of 2205 DSS are in good agreement with the experimental results.

  20. Experimental and computational study on microstructural evolution in 2205 duplex stainless steel during high temperature aging

    Energy Technology Data Exchange (ETDEWEB)

    He Yanlin, E-mail: ylhe@staff.shu.edu.cn [School of Materials Science and Engineering, Shanghai University, Shanghai 200072 (China); Zhu Naqiong; Lu Xiaogang; Li Lin [School of Materials Science and Engineering, Shanghai University, Shanghai 200072 (China)

    2010-12-15

    Research highlights: {yields} {sigma} is the first phase to appear at higher temperature because of rapid growth rate. {yields} Thermodynamic driving force for {chi} phase is always larger than that for {sigma} phase. {yields} The kinetic calculation on the migration of {gamma}/{alpha} interface during aging is present. - Abstract: 2205 duplex stainless steel (DSS) aged at temperatures between 700 deg. C and 1050 deg. C for different time intervals (5 min, 0.5 h, 1 h, 2 h) is studied. The evolution of secondary phases and the matrix with variation of aging time and temperature are measured by means of optical metallography (OM), SEM and EDS and BSE. The impact toughness, which reflects the effects of secondary phases, is also measured. It is shown that {sigma} is the dominant secondary phase in the matrix. The {sigma} phase precipitates at the austenite/ferrite boundaries or within ferritic grains, with the volume percent increasing with aging time and maximizing at 850 deg. C. Aided by Thermo-Calc software, the thermodynamic driving forces for {chi} phase and {sigma} phase are calculated. Although the driving force for {chi} phase is larger than that for {sigma} phase between 700 deg. C and 900 deg. C, {sigma} phase appears before {chi} phase because of its rapid growth rate at higher aging temperatures. According to the OM analysis and thermodynamic calculations, 2205 DSS at aging temperatures above 1000 deg. C is composed of ferrite and austenite, its volume fraction of ferrite increases with the increase of aging temperature. Moreover, the kinetic calculation on the migration of austenite/ferrite interface after different aging time is present. The thermodynamic and kinetic calculation results on the microstructural evolution of 2205 DSS are in good agreement with the experimental results.

  1. Experimental research on English vowel errors analysis

    Directory of Open Access Journals (Sweden)

    Huang Qiuhua

    2016-01-01

    Full Text Available Our paper analyzed relevant acoustic parameters of people’s speech samples and the results that compared with English standard pronunciation with methods of experimental phonetics by phonetic analysis software and statistical analysis software. Then we summarized phonetic pronunciation errors of college students through the analysis of English pronunciation of vowels, we found that college students’ English pronunciation are easy occur tongue position and lip shape errors during pronounce vowels. Based on analysis of pronunciation errors, we put forward targeted voice training for college students’ English pronunciation, eventually increased the students learning interest, and improved the teaching of English phonetics.

  2. Water age and stream solute dynamics at the Hubbard Brook Experimental Forest (US)

    Science.gov (United States)

    Botter, Gianluca; Benettin, Paolo; McGuire, Kevin; Rinaldo, Andrea

    2016-04-01

    The contribution discusses experimental and modeling results from a headwater catchment at the Hubbard Brook Experimental Forest (New Hampshire, USA) to explore the link between stream solute dynamics and water age. A theoretical framework based on water age dynamics, which represents a general basis for characterizing solute transport at the catchment scale, is used to model both conservative and weathering-derived solutes. Based on the available information about the hydrology of the site, an integrated transport model was developed and used to estimate the relevant hydrochemical fluxes. The model was designed to reproduce the deuterium content of streamflow and allowed for the estimate of catchment water storage and dynamic travel time distributions (TTDs). Within this framework, dissolved silicon and sodium concentration in streamflow were simulated by implementing first-order chemical kinetics based explicitly on dynamic TTD, thus upscaling local geochemical processes to catchment scale. Our results highlight the key role of water stored within the subsoil glacial material in both the short-term and long-term solute circulation at Hubbard Brook. The analysis of the results provided by the calibrated model allowed a robust estimate of the emerging concentration-discharge relationship, streamflow age distributions (including the fraction of event water) and storage size, and their evolution in time due to hydrologic variability.

  3. Functional recovery in aging mice after experimental stroke

    OpenAIRE

    Manwani, Bharti; Liu, Fudong; Xu, Yan; Persky, Rebecca; Li, Jun; McCullough, Louise D.

    2011-01-01

    Aging is a non modifiable risk factor for stroke. Since not all strokes can be prevented, a major emerging area of research is the development of effective strategies to enhance functional recovery after stroke. However, in the vast majority of pre-clinical stroke studies, the behavioral tests used to assess functional recovery have only been validated for use in young animals, or are designed for rats. Mice are increasingly utilized in stroke models but well validated behavioral tests design...

  4. Experimental Finite Element Approach for Stress Analysis

    Directory of Open Access Journals (Sweden)

    Ahmet Erklig

    2014-01-01

    Full Text Available This study aims to determining the strain gauge location points in the problems of stress concentration, and it includes both experimental and numerical results. Strain gauges were proposed to be positioned to corresponding locations on beam and blocks to related node of elements of finite element models. Linear and nonlinear cases were studied. Cantilever beam problem was selected as the linear case to approve the approach and conforming contact problem was selected as the nonlinear case. An identical mesh structure was prepared for the finite element and the experimental models. The finite element analysis was carried out with ANSYS. It was shown that the results of the experimental and the numerical studies were in good agreement.

  5. Ageing behaviour of electrochemical double layer capacitors. Part I. Experimental study and ageing model

    Energy Technology Data Exchange (ETDEWEB)

    Bohlen, Oliver; Kowal, Julia; Sauer, Dirk Uwe [Institute for Power Electronics and Electrical Drives ISEA, RWTH Aachen University, Aachen (Germany)

    2007-10-11

    Different types of commercially available electrochemical double layer capacitors (EDLCs) were analysed in accelerated ageing tests by impedance spectroscopy. From these measurements the parameters of an impedance model were determined. The characteristic change of the impedance parameters is discussed and an ageing model for EDLCs is developed. (author)

  6. Linking water age and solute dynamics in streamflow at the Hubbard Brook Experimental Forest, NH, USA

    Science.gov (United States)

    Benettin, Paolo; Bailey, Scott W.; Campbell, John L.; Green, Mark B.; Rinaldo, Andrea; Likens, Gene E.; McGuire, Kevin J.; Botter, Gianluca

    2015-11-01

    We combine experimental and modeling results from a headwater catchment at the Hubbard Brook Experimental Forest (HBEF), New Hampshire, USA, to explore the link between stream solute dynamics and water age. A theoretical framework based on water age dynamics, which represents a general basis for characterizing solute transport at the catchment scale, is here applied to conservative and weathering-derived solutes. Based on the available information about the hydrology of the site, an integrated transport model was developed and used to compute hydrochemical fluxes. The model was designed to reproduce the deuterium content of streamflow and allowed for the estimate of catchment water storage and dynamic travel time distributions (TTDs). The innovative contribution of this paper is the simulation of dissolved silicon and sodium concentration in streamflow, achieved by implementing first-order chemical kinetics based explicitly on dynamic TTD, thus upscaling local geochemical processes to catchment scale. Our results highlight the key role of water stored within the subsoil glacial material in both the short-term and long-term solute circulation. The travel time analysis provided an estimate of streamflow age distributions and their evolution in time related to catchment wetness conditions. The use of age information to reproduce a 14 year data set of silicon and sodium stream concentration shows that, at catchment scales, the dynamics of such geogenic solutes are mostly controlled by hydrologic drivers, which determine the contact times between the water and mineral interfaces. Justifications and limitations toward a general theory of reactive solute circulation at catchment scales are discussed.

  7. Experimental analysis of direct thermal methane cracking

    OpenAIRE

    Abánades Velasco, Alberto; Martínez-Val Peñalosa, Jose Maria; Ruíz, E.; Ferruelo, E. M.; Hernández, F.; Cabanillas, A.; Rubio, J.A.; López, C.; Gavela, R.; G. Barrera; Rubbia, C.; Salmieri, D.; Rodilla, E.; Gutiérrez, D

    2011-01-01

    The analysis of the viability of Hydrogen production without CO2 emissions is one of the most challenging activities that have been initiated for a sustainable energy supply. As one of the tracks to fulfil such objective, direct methane cracking has been analysed experimentally to assess the scientific viability and reaction characterization in a broad temperature range, from 875 to 1700 ?C. The effect of temperature, sweeping/carrier gas fraction proposed in some concepts, methane flow ...

  8. Categorical Data Analysis in Experimental Biology

    OpenAIRE

    Xu, Bo; Feng, Xuyan; Rebecca D Burdine

    2010-01-01

    The categorical data set is an important data class in experimental biology and contains data separable into several mutually exclusive categories. Unlike measurement of a continuous variable, categorical data can not be analyzed with methods such as the student’s t-test. Thus, these data require a different method of analysis to aid in interpretation. In this article, we will review issues related to categorical data, such as how to plot them in a graph, how to integrate results from differe...

  9. Epigenetic age analysis of children who seem to evade aging.

    Science.gov (United States)

    Walker, Richard F; Liu, Jia Sophie; Peters, Brock A; Ritz, Beate R; Wu, Timothy; Ophoff, Roel A; Horvath, Steve

    2015-05-01

    We previously reported the unusual case of a teenage girl stricken with multifocal developmental dysfunctions whose physical development was dramatically delayed resulting in her appearing to be a toddler or at best a preschooler, even unto the occasion of her death at the age of 20 years. Her life-long physician felt that the disorder was unique in the world and that future treatments for age-related diseases might emerge from its study. The objectives of our research were to determine if other such cases exist, and if so, whether aging is actually slowed. Of seven children characterized by dramatically slow developmental rates, five also had associated disorders displayed by the first case. All of the identified subjects were female. To objectively measure the age of blood tissue from these subjects, we used a highly accurate biomarker of aging known as "epigenetic clock" based on DNA methylation levels. No statistically significant differences in chronological and epigenetic ages were detected in any of the newly discovered cases. PMID:25991677

  10. Experimental analysis of computer system dependability

    Science.gov (United States)

    Iyer, Ravishankar, K.; Tang, Dong

    1993-01-01

    This paper reviews an area which has evolved over the past 15 years: experimental analysis of computer system dependability. Methodologies and advances are discussed for three basic approaches used in the area: simulated fault injection, physical fault injection, and measurement-based analysis. The three approaches are suited, respectively, to dependability evaluation in the three phases of a system's life: design phase, prototype phase, and operational phase. Before the discussion of these phases, several statistical techniques used in the area are introduced. For each phase, a classification of research methods or study topics is outlined, followed by discussion of these methods or topics as well as representative studies. The statistical techniques introduced include the estimation of parameters and confidence intervals, probability distribution characterization, and several multivariate analysis methods. Importance sampling, a statistical technique used to accelerate Monte Carlo simulation, is also introduced. The discussion of simulated fault injection covers electrical-level, logic-level, and function-level fault injection methods as well as representative simulation environments such as FOCUS and DEPEND. The discussion of physical fault injection covers hardware, software, and radiation fault injection methods as well as several software and hybrid tools including FIAT, FERARI, HYBRID, and FINE. The discussion of measurement-based analysis covers measurement and data processing techniques, basic error characterization, dependency analysis, Markov reward modeling, software-dependability, and fault diagnosis. The discussion involves several important issues studies in the area, including fault models, fast simulation techniques, workload/failure dependency, correlated failures, and software fault tolerance.

  11. Enhanced experimental tumor metastasis with age in senescence-accelerated mouse

    International Nuclear Information System (INIS)

    Tumor metastasis is affected by the host immune surveillance system. Since aging may attenuate the host immune potential, the experimental tumor metastasis may be enhanced with age. In the present study, we investigated this alteration of experimental tumor metastasis with age. We used senescence-accelerated mice prone 10 (SAMP10) as a model of aged animals. Natural killer cell (NK) activity, as an indicator of immune surveillance potential, in 8-month-old (aged) SAMP10 mice was observed to be much lower than that in 2-month-old (young) mice. When we examined the in vivo trafficking of lung-metastatic K1735M2 melanoma cells in SAMP10 with positron emission tomography (PET), K1735M2 cells labeled with [2-18F]2-deoxy-2-fluoro-D-glucose ([18F]FDG) were observed in both young and aged SAMP10 just after injection of the cells, whereas the clearance of 18F from the lungs was retarded in aged animals. The accumulation of 5-[125I]iodo-2'-deoxyuridine ([125I]IUdR)-labeled K1735M2 cells in the lungs of SAMP10 at 24 h after injection was significantly higher in aged mice. Corresponding to these results, the number of metastatic colonies in the lung was larger in the aged SAMP10 of the experimental tumor metastasis model. The present study demonstrated that the aging process produced a susceptible environment allowing the tumor cells to metastasize due to decrease in the host immune surveillance potential with age. (author)

  12. Experimental and analysis methods in radiochemical experiments

    Science.gov (United States)

    Cattadori, C. M.; Pandola, L.

    2016-04-01

    Radiochemical experiments made the history of neutrino physics by achieving the first observation of solar neutrinos (Cl experiment) and the first detection of the fundamental pp solar neutrinos component (Ga experiments). They measured along decades the integral νe charged current interaction rate in the exposed target. The basic operation principle is the chemical separation of the few atoms of the new chemical species produced by the neutrino interactions from the rest of the target, and their individual counting in a low-background counter. The smallness of the expected interaction rate (1 event per day in a ˜ 100 ton target) poses severe experimental challenges on the chemical and on the counting procedures. The main aspects related to the analysis techniques employed in solar neutrino experiments are reviewed and described, with a special focus given to the event selection and the statistical data treatment.

  13. Experimental and analysis methods in radiochemical experiments

    Energy Technology Data Exchange (ETDEWEB)

    Cattadori, C.M. [INFN, Milano (Italy); Pandola, L. [Laboratori Nazionali del Sud, INFN, Catania (Italy); Gran Sasso Science Institute, INFN, L' Aquila (Italy)

    2016-04-15

    Radiochemical experiments made the history of neutrino physics by achieving the first observation of solar neutrinos (Cl experiment) and the first detection of the fundamental pp solar neutrinos component (Ga experiments). They measured along decades the integral ν{sub e} charged current interaction rate in the exposed target. The basic operation principle is the chemical separation of the few atoms of the new chemical species produced by the neutrino interactions from the rest of the target, and their individual counting in a low-background counter. The smallness of the expected interaction rate (1 event per day in a ∝ 100 ton target) poses severe experimental challenges on the chemical and on the counting procedures. The main aspects related to the analysis techniques employed in solar neutrino experiments are reviewed and described, with a special focus given to the event selection and the statistical data treatment. (orig.)

  14. Do different neurons age differently? Direct genome-wide analysis of aging in single identified cholinergic neurons

    Directory of Open Access Journals (Sweden)

    Leonid L Moroz

    2010-05-01

    Full Text Available Aplysia californica is a powerful experimental system to study the entire scope of genomic and epigenomic regulation at the resolution of single functionally characterized neurons and is an emerging model in the neurobiology of aging. First, we have identified and cloned a number of evolutionarily conserved genes that are age-related, including components of apoptosis and chromatin remodeling. Second, we performed gene expression profiling of different identified cholinergic neurons between young and aged animals. Our initial analysis indicates that two cholinergic neurons (R2 and LPl1 revealed highly differential genome-wide changes following aging suggesting that on the molecular scale different neurons indeed age differently. Each of neurons tested has a unique subset of genes differentially expressed in older animals, and the majority of differently expressed genes (including those related to apoptosis and Alzheimer’s disease are found in aging neurons of one but not another type. The performed analysis allows us to implicate (i cell specific changes in histones, (ii DNA methylation and (iii regional relocation of RNAs as key processes underlying age-related changes in neuronal functions and synaptic plasticity. These mechanisms can fine-tune the dynamics of long-term chromatin remodeling, or control weakening and the loss of synaptic connections in aging. At the same time our genomic tests revealed evolutionarily conserved gene clusters associated with aging (e.g. apoptosis-, telomere- and redox- dependent processes, insulin and estrogen signaling and water channels.

  15. EXPERIMENTAL MODAL ANALYSIS OF VISCO-ELASTICALLY DAMPED STRUCTURES

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    The form of the modal analysis of viscoelastically damped structures is simplified and this simplified form is similar to the form of the modal analysis of linear viscously damped structures. As a result of this simplified form, the experimental modal analysis methods of linear viscously damped structures are applied to the experimental modal analysis of viscoelastically damped structures.

  16. Raman microprobe analysis and ageing in dielectrics

    International Nuclear Information System (INIS)

    Subsurface voids in samples of electrically stressed low density polyethylene (LDPE) were analysed using confocal Raman microprobe spectroscopy (CRMS). An optical depth profiling technique was used to probe a void along the optic axis whilst a burst void was analysed at various lateral positions. Spectra from the voided samples showed signatures with similar features to those found in previous studies of electrical trees in polyethylene, including the presence of the D and G bands of disordered sp2 carbon. Results and spectra were then compared to the depth profiles and spectra from block and thin film samples of polyethylene and polystyrene which indicated that the established theory behind CRMS is oversimplified and that the detected signal is largely influenced by the optical properties of the material in question. Overall the study showed that despite some spatial resolution limitations of the technique, depth profiling is a useful tool in the analysis of aged polymers and dielectrics as it can show the variations in chemical composition with respect to position along the lateral and optic axis, a property especially relevant to electrical trees.

  17. Experimental Study to Determine the Failure Criteria of Concrete at Its Early-Age

    OpenAIRE

    Hongyan Ding; Lei Zhang; Puyang Zhang

    2015-01-01

    The failure criteria and the constitutive relation of materials for an early-age concrete are the most common reasons to conduct the nonlinear analysis and to assess the concrete structures during the construction stage. The delay of theoretical advancement in this field resulted into a mismatch between the rough theories and the advanced algorithms, which were adopted for the estimation and analysis of early-age concrete structures. It is often impossible to find an appropriate way to determ...

  18. Analysis of the tensile behaviour of zircaloy-4 in the region of dynamic strain aging

    International Nuclear Information System (INIS)

    An analysis of the tensile behavior of Zircaloy 4, centering around the influence of dynamic strain aging and strain rate history, is presented. This analysis is based on techniques introduced by Jaoul-Crussard and Reed-Hill. An attempt is also made to assess the experimental errors that influence these methods. (author)

  19. A genome-wide longitudinal transcriptome analysis of the aging model Podospora anserina.

    Directory of Open Access Journals (Sweden)

    Oliver Philipp

    Full Text Available Aging of biological systems is controlled by various processes which have a potential impact on gene expression. Here we report a genome-wide transcriptome analysis of the fungal aging model Podospora anserina. Total RNA of three individuals of defined age were pooled and analyzed by SuperSAGE (serial analysis of gene expression. A bioinformatics analysis identified different molecular pathways to be affected during aging. While the abundance of transcripts linked to ribosomes and to the proteasome quality control system were found to decrease during aging, those associated with autophagy increase, suggesting that autophagy may act as a compensatory quality control pathway. Transcript profiles associated with the energy metabolism including mitochondrial functions were identified to fluctuate during aging. Comparison of wild-type transcripts, which are continuously down-regulated during aging, with those down-regulated in the long-lived, copper-uptake mutant grisea, validated the relevance of age-related changes in cellular copper metabolism. Overall, we (i present a unique age-related data set of a longitudinal study of the experimental aging model P. anserina which represents a reference resource for future investigations in a variety of organisms, (ii suggest autophagy to be a key quality control pathway that becomes active once other pathways fail, and (iii present testable predictions for subsequent experimental investigations.

  20. Emotionality and Aging: A Theoretical and Empirical Analysis.

    Science.gov (United States)

    Schulz, Richard

    1982-01-01

    Discusses semantic issues in defining emotions. Describes important constructs derived from major theories of emotionality. Examines social-psychological and biological changes associated with aging in the context of these theories. Reviews available data on emotionality and aging, describing experimental attempts at manipulating the emotional…

  1. Does Age Effect Dual-tasking Ability? Data from Healthy Participants using a new Experimental Paradigm.

    OpenAIRE

    Ghazali, Zayba

    2011-01-01

    OBJECTIVES: This study aimed to explore age-related differences in dual-tasking. Previous studies report no age-effects in dual-tasking among healthy individuals in comparison to severe dual-tasking impairment in Alzheimer’s disease patients (Baddeley et al., 1986; Logie et al., 2004; MacPherson et al., 2007). This study aimed to replicate these findings using a new experimental paradigm: Fitts’ Box. Dual-tasking ability is thought to rely on the central executive (CE) component of working me...

  2. Experimental reproducibility analysis in DU hydriding

    Energy Technology Data Exchange (ETDEWEB)

    Koo, Daeseo; Park, Jongcheol; Chung, Hongsuk [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    A storage and delivery system (SDS) is used for storing hydrogen isotopes as a metal hydride form. The rapid hydriding of tritium is very important not only for safety reasons but also for the economic design and operation of the SDS. For the storage, supply, and recovery of hydrogen isotopes, depleted uranium (DU) has been extensively proposed. To develop nuclear fusion technology, it will be necessary to store and supply hydrogen isotopes needed for Tokamak operation. The experimental reproducibility of bed temperature on DU hydriding was also analyzed. The experimental reproducibility of apparatus was acceptable for all the experiments. The experimental reproducibility of tank pressure on DU hydriding was analyzed. As the hydriding performs, the tank pressure showed decreasing trend. The experimental reproducibility of bed temperature on DU hydriding was also analyzed. As the hydriding performs, the bed temperatures increased up to maximum temperature with exothermic reaction and then they showed decreasing trend. The experimental reproducibility of apparatus was acceptable for all the experiments.

  3. Experimental Study on Early-Age Crack of Mass Concrete under the Controlled Temperature History

    OpenAIRE

    Nannan Shi; Jianshu Ouyang; Runxiao Zhang; Dahai Huang

    2014-01-01

    Thermal deformation under restrained conditions often leads to early-age cracking and durability problems in mass concrete structures. It is crucial to monitor accurately the evolution of temperature and thermal stresses. In this paper, experimental studies using temperature stress testing machine (TSTM) are carried out to monitor the generated thermal cracking in mass concrete. Firstly, components and working principle of TSTM were introduced. Cracking temperatures and stress reserves are se...

  4. [Thermodynamic theory of biological evolution and aging. Experimental verification of the theory].

    Science.gov (United States)

    Gladyshev, G P

    2000-01-01

    Experimental data confirming original thermodynamic theory of biological evolution and aging are presented. Biological evolution (phylogenesis) and ontogenesis can be easily described within the frames of equilibrium hierarchical thermodynamics on the basis of temporal hierarchies law and the second principle of thermodynamics. The theory explains many facts and suggests new practical proposals in medical and biological science, particularly, in dietology, gerontology, and geriatrics. Application of the temporal hierarchies model to studying living nature offers horizonless possibilities for its understanding.

  5. Thermodynamic Theory of Biological Evolution and Aging. Experimental Confirmation of Theory

    OpenAIRE

    Gladyshev, Georgi P.

    1999-01-01

    Abstract: The work presents experimental confirmation of the author's thermodynamic theory of the biological evolution and aging of living beings. It shows that using the law of temporal hierarchies and the second law of thermodynamics, it is easy to describe biological evolution (phylogeny) and ontogeny in terms of equilibrium hierarchical thermodynamics. This theory explains many known facts and makes it possible to formulate new practical recommendations in the sphere of medical and biolog...

  6. ANOVA like analysis of cancer death age

    Science.gov (United States)

    Areia, Aníbal; Mexia, João T.

    2016-06-01

    We use ANOVA to study the influence of year, sex, country and location on the average cancer death age. The data used was from the World Health Organization (WHO) files for 1999, 2003, 2007 and 2011. The locations considered were: kidney, leukaemia, melanoma of skin and oesophagus and the countries: Portugal, Norway, Greece and Romania.

  7. Design of a management information system for the Shielding Experimental Reactor ageing management

    Energy Technology Data Exchange (ETDEWEB)

    He Jie, E-mail: hejiejoe@163.co [Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 100084 (China); Xu Xianhong [Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 100084 (China)

    2010-01-15

    The problem of nuclear reactor ageing is a topic of increasing importance in nuclear safety recent years. Ageing management is usually implemented for reactors maintenance. In the practice, a large number of data and records need to be processed. However, there are few professional software applications that aid reactor ageing management, especially for research reactors. This paper introduces the design of a new web-based management information system (MIS), named the Shielding Experimental Reactor Ageing Management Information System (SERAMIS). It is an auxiliary means that helps to collect data, keep records, and retrieve information for a research reactor ageing management. The Java2 Enterprise Edition (J2EE) and network database techniques, such as three-tiered model, Model-View-Controller architecture, transaction-oriented operations, and JavaScript techniques, are used in the development of this system. The functionalities of the application cover periodic safety review (PSR), regulatory references, data inspection, and SSCs classification according to ageing management methodology. Data and examples are presented to demonstrate the functionalities. For future work, techniques of data mining will be employed to support decision-making.

  8. Ultrasound Determination of Gestational Age Using Placental Thickness in Female Dogs: An Experimental Study

    Directory of Open Access Journals (Sweden)

    André Luiz Louzada Maldonado

    2012-01-01

    Full Text Available Objective. To verify if the placental thickness allows determining the gestational age, evaluating the correlation between the referred gestational age with the studied one, and the accuracy of the placental thickness measurement (biometry with fetal morphologic parameters in bitches. Methods. The placental thickness of 336 bitches of diverse breeds was evaluated. Bitches were divided in three groups by body weight: small, medium, and big large size. The gestations pregnancies were evaluated by ultrasound from the third week of gestation. An analysis was performed between the mean values of the gestational age obtained of placental thickness by adjustment of curves and the reported gestational age. Student's t-test was applied to compare the mean of reported and placental thickness gestational age. Significance was defined as P<0.05. Results. A positive and statistically significant correlation exists between the placental thickness and gestational age. The expression that presents the best correlation coefficient and explanation was thickness of placenta = 0.021x gestational age −0.314. Conclusion. It is possible to determine the gestational age in relation to the placental thickness measured by ultrasound in bitches with a satisfactory accuracy in relation to fetal morphologic parameters as gestational vesicle, ribs, or kidneys.

  9. Ultrasound determination of gestational age using placental thickness in female dogs: an experimental study.

    Science.gov (United States)

    Maldonado, André Luiz Louzada; Araujo Júnior, Edward; Mendonça, Débora Sartori; Nardozza, Luciano Marcondes Machado; Moron, Antonio Fernandes; Ajzen, Sérgio Aron

    2012-01-01

    Objective. To verify if the placental thickness allows determining the gestational age, evaluating the correlation between the referred gestational age with the studied one, and the accuracy of the placental thickness measurement (biometry) with fetal morphologic parameters in bitches. Methods. The placental thickness of 336 bitches of diverse breeds was evaluated. Bitches were divided in three groups by body weight: small, medium, and big large size. The gestations pregnancies were evaluated by ultrasound from the third week of gestation. An analysis was performed between the mean values of the gestational age obtained of placental thickness by adjustment of curves and the reported gestational age. Student's t-test was applied to compare the mean of reported and placental thickness gestational age. Significance was defined as P < 0.05. Results. A positive and statistically significant correlation exists between the placental thickness and gestational age. The expression that presents the best correlation coefficient and explanation was thickness of placenta = 0.021x gestational age -0.314. Conclusion. It is possible to determine the gestational age in relation to the placental thickness measured by ultrasound in bitches with a satisfactory accuracy in relation to fetal morphologic parameters as gestational vesicle, ribs, or kidneys. PMID:22848867

  10. Experimental analysis of cut welding in aluminium

    DEFF Research Database (Denmark)

    Dorph, Pernille; De Chiffre, Leonardo; Bay, Niels

    1993-01-01

    Cut welding is a newly developed cold pressure welding process. In the present work, an experimental investigation was carried out analyzing the mechanisms involved in cut welding of a block to a strip. Experiments were carried out in technically pure aluminium. The investigation has involved...

  11. Marine Mammal Train Oil Production Methods: Experimental Reconstructions of Norwegian Iron Age Slab-Lined Pits

    Science.gov (United States)

    Nilsen, Gørill

    2016-08-01

    Seal hunting and whaling have played an important part of people's livelihoods throughout prehistory as evidenced by rock carvings, remains of bones, artifacts from aquatic animals and hunting tools. This paper focuses on one of the more elusive resources relating to such activities: marine mammal blubber. Although marine blubber easily decomposes, the organic material has been documented from the Mesolithic Period onwards. Of particular interest in this article are the many structures in Northern Norway from the Iron Age and in Finland on Kökar, Åland, from both the Bronze and Early Iron Ages in which these periods exhibited traits interpreted as being related to oil rendering from marine mammal blubber. The article discusses methods used in this oil production activity based on historical sources, archaeological investigations and experimental reconstruction of Iron Age slab-lined pits from Northern Norway.

  12. Marine Mammal Train Oil Production Methods: Experimental Reconstructions of Norwegian Iron Age Slab-Lined Pits

    Science.gov (United States)

    Nilsen, Gørill

    2016-02-01

    Seal hunting and whaling have played an important part of people's livelihoods throughout prehistory as evidenced by rock carvings, remains of bones, artifacts from aquatic animals and hunting tools. This paper focuses on one of the more elusive resources relating to such activities: marine mammal blubber. Although marine blubber easily decomposes, the organic material has been documented from the Mesolithic Period onwards. Of particular interest in this article are the many structures in Northern Norway from the Iron Age and in Finland on Kökar, Åland, from both the Bronze and Early Iron Ages in which these periods exhibited traits interpreted as being related to oil rendering from marine mammal blubber. The article discusses methods used in this oil production activity based on historical sources, archaeological investigations and experimental reconstruction of Iron Age slab-lined pits from Northern Norway.

  13. Multifractal age? Multifractal analysis of cardiac interbeat intervals in assessing of healthy aging

    CERN Document Server

    Makowiec, Danuta; Wdowczyk-Szulc, Joanna; Zarczynska-Buchowiecka, Marta; Gruchal, Marcin; Rynkiewicz, Andrzej

    2013-01-01

    24-hour Holter recordings of 124 healthy people at different age are studied. The nocturnal signals of young people reveal the presence of the multiplicative structure. This structure is significantly weaker in diurnal signals and becomes less evident for elderly people. Multifractal analysis allows us to propose qualitative and quantitative methods to estimate the advancement of the aging process for healthy humans.

  14. Phosphoproteomic analysis of aged skeletal muscle.

    Science.gov (United States)

    Gannon, Joan; Staunton, Lisa; O'Connell, Kathleen; Doran, Philip; Ohlendieck, Kay

    2008-07-01

    One of the most important post-translational modifications is represented by phosphorylation on tyrosine, threonine and serine residues. Since abnormal phosphorylation is associated with various pathologies, it was of interest to perform a phosphoproteomic profiling of age-related skeletal muscle degeneration. We used the fluorescent phospho-specific Pro-Q Diamond dye to determine whether changes in the overall phosphorylation of the soluble skeletal muscle proteome differs significantly between young adult and senescent fibres. As an established model system of sarcopenia, we employed 30-month-old rat gastrocnemius fibres. Following the mass spectrometric identification of 59 major 2-D phosphoprotein landmark spots, the fluorescent dye staining survey revealed that 22 muscle proteins showed a differential expression pattern between 3-month- and 30-month-old muscle. Increased phosphorylation levels were shown for myosin light chain 2, tropomyosin alpha, lactate dehydrogenase, desmin, actin, albumin and aconitase. In contrast, decreased phospho-specific dye binding was observed for cytochrome c oxidase, creatine kinase and enolase. Thus, aging-induced alterations in phosphoproteins appear to involve the contractile machinery and the cytoskeleton, as well as the cytosolic and mitochondrial metabolism. This confirms that sarcopenia of old age is a complex neuromuscular pathology that is associated with drastic changes in the abundance and structure of key muscle proteins. PMID:18575773

  15. CFD analysis of evaporation cooling experimental tests

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosini, W.; Forgione, N.; Mazzini, D.; Oriolo, F. [Pisa Univ., DIMNP (Italy); He, S. [British Energy Generation Ltd, Barnwood Gloucester (United Kingdom)

    2001-07-01

    Falling film evaporation cooling is investigated by a CFD (computational fluid dynamics) code. The experimental activity, carried out at the University of Pisa using the EFFE facility, is aimed to contribute to the understanding of the heat and mass transfer mechanisms involved in cooling of a metallic wall by evaporation of falling water films in a countercurrent air flow. This problem is relevant for innovative nuclear reactor containment. The mathematical model, the governing equations and the boundary conditions implemented in the code are briefly described; a detailed description of the method adopted to account for mass transfer and the presence of the film follows. Then, the calculated results are analysed and compared with experimental data, highlighting the improvement in the cooling capabilities obtained owing to evaporation with respect to the case of pure convection. (authors)

  16. Histochemical analysis of experimental granulomatous uveitis.

    Science.gov (United States)

    Kristeva, M; Biswas, J; Pararajasegaram, G; Sevanian, A; Rao, N A

    1991-01-01

    We have previously demonstrated the effects of various inhibitors of arachidonic acid metabolism on experimental lens-induced granulomatous uveitis. In the present study, we investigated the effect of these same inhibitors on the expression of lysosomal enzymes at different stages of choroidal inflammation in experimental lens-induced granulomatous uveitis and compared this to the inflammation observed at each stage examined. Lysosomal enzymes such as acid phosphatase, beta-glucuronidase and succinate dehydrogenase are known to be liberated during the maturation of mononuclear phagocytes to epithelioid cell granulomas. Although animals treated with nordihydroguaiaretic acid showed less severe inflammation than did indomethacin-treated or control animals, none of these agents appeared to affect the expression of acid phosphatase and beta-glucuronidase, as determined histochemically. Succinate dehydrogenase could not be detected in any of the eyes examined, even though sections of liver and kidney from these same animals were positive for this enzyme.

  17. Fundamentals of statistical experimental design and analysis

    CERN Document Server

    Easterling, Robert G

    2015-01-01

    Professionals in all areas - business; government; the physical, life, and social sciences; engineering; medicine, etc. - benefit from using statistical experimental design to better understand their worlds and then use that understanding to improve the products, processes, and programs they are responsible for. This book aims to provide the practitioners of tomorrow with a memorable, easy to read, engaging guide to statistics and experimental design. This book uses examples, drawn from a variety of established texts, and embeds them in a business or scientific context, seasoned with a dash of humor, to emphasize the issues and ideas that led to the experiment and the what-do-we-do-next? steps after the experiment. Graphical data displays are emphasized as means of discovery and communication and formulas are minimized, with a focus on interpreting the results that software produce. The role of subject-matter knowledge, and passion, is also illustrated. The examples do not require specialized knowledge, and t...

  18. Numerically and experimentally analysis of creep

    International Nuclear Information System (INIS)

    The problems of creep in concrete are analyzed experimentally and numerically, comparing with classical methods and suggesting a numerical procedure for the solution of these problems. Firstly, fundamentals of viscoelasticity and its application to concrete behaviour representation are presented. Then the theories of Dischinger and Arutyunyan are studied, and a computing numerical solutions are compared in several examples. Finally, experiences on creep and relaxation are described, and its result are analyzed. Some coments on possible future developments are included. (Author)

  19. Experimental Analysis of a Vertical Drop Shaft

    Directory of Open Access Journals (Sweden)

    Giuseppe Del Giudice

    2013-09-01

    Full Text Available An experimental campaign is undertaken in order to investigate the hydraulic features of a vertical drop shaft, also considering the influence of a venting system consisting of a coaxial vertical pipe, projecting within the drop shaft with different plunging rates. Three different flow regimes are observed: a “weir flow” for very low head values, where the flow profile is subject to the atmospheric pressure; a “full flow” for high head values, where water flows in a pressurized regime along the whole shaft; and a “transitional flow” for intermediate water head values. Weir flow and full flow can be experimentally investigated under steady-state conditions, whereas transitional flow is a pulsating condition, alternately switching from full flow to weir flow. Considering some significant geometric parameters, a head-discharge relation is sought both for the non-vented and for the vented configurations, by means of an energy balance equation, with specific assumptions about intake losses.

  20. Experimental Investigation on Local Air Age and Air Distribution of Stratum Ventilation

    Institute of Scientific and Technical Information of China (English)

    WANG Feng-hao; LI Yuan-bin; LIU Xiao-dong; WANG Xin-ke

    2009-01-01

    Because of the multiple problems on high energy consumption and unbalanced thermal comfort caused by the traditional ventilation system,a new concept of ventilation-stratum ventilation has been proposed,which sends the fresh air to the breathing zone directly.In this paper,the local air distributions of the displace-ment ventilation and the stratum ventilation in a model office were measured.The air ages in the breathing zone for the displacement ventilation and stratum ventilation were compared with the tracer gas concentration decay method.The decay curves of tracer gas concentration for these two ventilation systems in the breathing zonewere obtained, and the air ages were calculated.The experimental results show that the stratum ventilation sys-tem can offer lower air age for four mechanically ventilated cases in the breathing zone,and it can also provide better thermal comfort,which renews the air of breathing zone more quickly and reduces the energy consump-tion in some degree.The experimental investigation provides a theoretical basis for the application of stratum ventilation system.

  1. Experimental Study on Early-Age Crack of Mass Concrete under the Controlled Temperature History

    Directory of Open Access Journals (Sweden)

    Nannan Shi

    2014-01-01

    Full Text Available Thermal deformation under restrained conditions often leads to early-age cracking and durability problems in mass concrete structures. It is crucial to monitor accurately the evolution of temperature and thermal stresses. In this paper, experimental studies using temperature stress testing machine (TSTM are carried out to monitor the generated thermal cracking in mass concrete. Firstly, components and working principle of TSTM were introduced. Cracking temperatures and stress reserves are selected as the main cracking evaluation indicators of TSTM. Furthermore, effects of temperature controlling measures on concrete cracking were quantitatively studied, which consider the concrete placing temperature (before cooling and cooling rates (after cooling. Moreover, the influence of reinforcement on early-age cracking has been quantitatively analyzed using the TSTM. The experimental results indicate that the crack probability of reinforced concrete (RC is overestimated. Theoretical calculations proved that the internal stress can transfer from concrete to reinforcement due to creep effect. Finally, the experimental results indicate that the reinforcement can improve the crack resistance of concrete by nearly 30% in the TSTM tests, and the ultimate tensile strain of RC is approximately 105% higher than that of plain concrete with the same mix proportions.

  2. Organization of DELPHI experimental data analysis

    International Nuclear Information System (INIS)

    The philosophy of the DELPI off-line interactive centre at CERN is presented briefly. The main purpose of this centre is to provide a fast turn-around and graphics support for the express analysis line. It should comprise 2 medium power computers of VAX type, 2-3 emulators 2-3 high resolution graphics facilities and 2-3 personal computers. The processing of the events at the DELPHI interactive centre will include the following steps: full processing of a small sample of events, futher reduction of this samples by physics analysis programs, detailed scanning and correction of the reduced sample, physics analysis of the sample of events. The DELPHI off-line software is considered

  3. Experimental febrile seizures induce age-dependent structural plasticity and improve memory in mice.

    Science.gov (United States)

    Tao, K; Ichikawa, J; Matsuki, N; Ikegaya, Y; Koyama, R

    2016-03-24

    Population-based studies have demonstrated that children with a history of febrile seizure (FS) perform better than age-matched controls at hippocampus-dependent memory tasks. Here, we report that FSs induce two distinct structural reorganizations in the hippocampus and bidirectionally modify future learning abilities in an age-dependent manner. Compared with age-matched controls, adult mice that had experienced experimental FSs induced by hyperthermia (HT) on postnatal day 14 (P14-HT) performed better in a cognitive task that requires dentate granule cells (DGCs). The enhanced memory performance correlated with an FS-induced persistent increase in the density of large mossy fiber terminals (LMTs) of the DGCs. The memory enhancement was not observed in mice that had experienced HT-induced seizures at P11 which exhibited abnormally located DGCs in addition to the increased LMT density. The ectopic DGCs of the P11-HT mice were abolished by the diuretic bumetanide, and this pharmacological treatment unveiled the masked memory enhancement. Thus, this work provides a novel basis for age-dependent structural plasticity in which FSs influence future brain function. PMID:26794590

  4. Thermodynamic Theory of Biological Evolution and Aging. Experimental Confirmation of Theory

    Science.gov (United States)

    Gladyshev, Georgi P.

    1999-12-01

    The work presents experimental confirmation of the author's thermodynamic theory of the biological evolution and aging of living beings. It shows that using the law of temporal hierarchies and the second law of thermodynamics, it is easy to describe biological evolution (phylogeny) and ontogeny in terms of equilibrium hierarchical thermodynamics. This theory explains many known facts and makes it possible to formulate new practical recommendations in the sphere of medical and biological disciplines, for instance, dietology, gerontology, and geriatrics. Using the models of temporal hierarchies when studying living nature, researchers can go a long way towards understanding it.

  5. Analytical and experimental analysis of magnetorheological elastomers

    Science.gov (United States)

    Trabia, Sarah

    Many engineering applications ranging from robotic joints to shock and vibration mitigation can benefit by incorporating components with variable stiffness. In addition, variable stiffness structures can provide haptic feedback (the sense of touch) to the user. In this work, it is proposed to study Magnetorheological Elastomers (MRE), where iron particles within the elastomer compound develop a dipole interaction energy, to be used in a device for haptic feedback. A novel feature of this MRE device is to introduce a field-induced variable shear modulus bias via a permanent magnet and using a current input to the electromagnetic control coil to change the modulus of the elastomer in both directions (softer or harder). In this preliminary work, both computational and experimental results of the proposed MRE design are presented. The design is created in COMSOL to verify that the magnetic field is in the desired direction. MRE was fabricated and characterized using a Bose Dynamic Mechanical Analyzer for the shear modulus. Using this information, it is possible to know how the MRE will react in magnetic fields within the haptic feedback device. Additionally, a model for an MRE is developed in a multi-physics COMSOL program that is linked to a MATLAB function that predicts the shear modulus and incorporates it into the material properties to best simulate the MRE's ability to change shear modulus.

  6. Lifestyle intervention as a treatment for obesity in school-age-children in Celaya, Guanajuato: An experimental study

    Directory of Open Access Journals (Sweden)

    Nicolas Padilla-Raygoza

    2013-03-01

    Full Text Available Introduction: Obesity is a risk factor in chronic diseases, and its frequency among children in Mexico is increasing. Objective: To determine the effect of lifestyle intervention as a treatment for obesity in school-age-children from Celaya, Mexico.Methodology: For this experimental study, four schools were randomly selected. Children and parents participated voluntarily and signed consent forms. Two schools were chosen as the experimental group and the other two formed the control group. Age, gender, weight, height, BMI and blood pressure were recorded for each participant. Intervention: Children and parents were asked to walk in their schools for 30 minutes a day Monday through Friday and to attend 8 instructional sessions over a period of four months dedicated to the selection and preparation of meals. Statistical Analysis: The OR and 95% CI were calculated to determine the effect of the intervention; a Z-test for two proportions for overweight and obesity in the control and experimental groups were carried out for comparison.Results: 157 children were included in the experimental group and 144 in the control group. To compare the proportions of the overweight and the obese between the groups, a Z-test = - 0.36 (p-value 0.72 were obtained showing no effect of the intervention in lifestyle; OR =1.09, 95% CI (0.67, 1.77. It was adjusted according to the attendance to the sessions resulting in an OR = 2.00, 95% CI (0.69, 5.77, demonstrating that not attending the sessions was a confounder.Conclusions: Intervention in lifestyle should be measured over a longer period of time in order to determine what effects it may have on changes in body mass index.

  7. Experimental analysis of nature-nurture interactions.

    Science.gov (United States)

    Wyman, Robert J

    2005-06-01

    The presumed opposition of nature and nurture has been a major concern of western civilization since its beginnings. Christian theologians interpreted Adam and Eve's eating of the forbidden fruit as the origin of an inherited 'original sin'. Saint Augustine explicitly applied the concept to human mental development, arguing that, because of original sin, children are inclined toward evil and education requires physical punishment. For centuries, it was considered parents' moral and religious obligation, not to nurture their children, in our current sense of that word, but to beat the willfulness out of them. 16thC humanists fought back, arguing that "schools have become torture chambers" while it is adults "who corrupt young minds with evil". Locke's (1690) statement that children are born as a 'white paper' was crucial in rejecting the dogma of an inborn (and sinful) nature. The original sin vs. white paper argument merged with another ancient dichotomy: inborn instinct (which controls animal behavior) vs. the reason and free will which humans have. Darwin made the concept of inherited instinct, common to both man and animals, one cornerstone of his theory of evolution. The 20(th)C saw scientists recast the debate as instinct vs. learning, bitterly argued between behaviorists and ethologists. Laboratory experimentation and field observation showed that behavior could develop without learning but also that conditioning paradigms could powerfully mold behavior. The progress of genetics and neurobiology has led to the modern synthesis that neural development, and hence behavior, results from the interdependent action of both heredity and environment. PMID:15880766

  8. 3-D Experimental Fracture Analysis at High Temperature

    Energy Technology Data Exchange (ETDEWEB)

    John H. Jackson; Albert S. Kobayashi

    2001-09-14

    T*e, which is an elastic-plastic fracture parameter based on incremental theory of plasticity, was determined numerically and experimentally. The T*e integral of a tunneling crack in 2024-T3 aluminum, three point bend specimen was obtained through a hybrid analysis of moire interferometry and 3-D elastic-plastic finite element analysis. The results were verified by the good agreement between the experimentally and numerically determined T*e on the specimen surface.

  9. Experimental Bifurcation Analysis Using Control-Based Continuation

    DEFF Research Database (Denmark)

    Bureau, Emil; Starke, Jens

    The focus of this thesis is developing and implementing techniques for performing experimental bifurcation analysis on nonlinear mechanical systems. The research centers around the newly developed control-based continuation method, which allows to systematically track branches of stable and unsta......The focus of this thesis is developing and implementing techniques for performing experimental bifurcation analysis on nonlinear mechanical systems. The research centers around the newly developed control-based continuation method, which allows to systematically track branches of stable...

  10. Experimental Analysis of Sandstone and Travertine

    Directory of Open Access Journals (Sweden)

    T. Doležel

    2004-01-01

    Full Text Available Sandstone and travertine are sedimentary rocks. The former is clastic, while the latter is sourced by chemical precipitation from hot springs. Their applications in civil engineering structures are mostly influenced by the ability to carry compression loading. A three-point bending experiment is usually used to determine material characteristics. However it does not correspond very well to applicatiosn in structures. For this reason we used a uniaxial compression test to obtain the modulus of elasticity and the stress-strain diagram. To obtain detailed information about the crystalline structure of sandstone and travertine a microscopic analysis wascarried out, using optical microscopy and an EDAX multichannel spectrometer for elementary microanalysis. 

  11. Experimental analysis of Scheffler reflector water heater

    Directory of Open Access Journals (Sweden)

    Patil Rupesh

    2011-01-01

    Full Text Available The performance of Scheffler reflector has been studied. In this system storage reservoir was installed at Focus point. It has a single large diameter drum which serves the dual purpose of absorber tube and storage tank. The drum is sized to have a storage capacity of 20 liter for experiment. The tests were carried out with this set up and were repeated for several days. Performance analysis of the collector has revealed that the average power and efficiency in terms of water boiling test to be 1.30 kilowatts and 21.61 % respectively against an average value of beam radiations of 742[Wm-2]. The maximum water temperature in the storage tank of 98°C has been achieved on a clear day operation and ambient temperature between 28°C to 31°C.

  12. Experimental results and analysis on hydrogen combustion

    International Nuclear Information System (INIS)

    The Small-Scale Development Apparatus (SSDA) was constructed to provide a preliminary set of experimental data to characterize the effect of temperature on the ability of hydrogen-air-steam-mixtures to undergo detonations and, equally important, to support design of the larger-scale High-Temperature Combustion Facility (HTCF) by providing a test bed for solution of a number of high-temperature design and operational problems. The SSDA, the central element of which is 10-cm inside diameter, 6.1-m long tubular test vessel designed to permit detonation experiments at temperatures up to 700K, was employed to study self-sustained detonations in gaseous mixtures of hydrogen, air, and steam at temperature between 300K and 650K at a fixed pressure of 0.1 MPa. Detonation cell size measurements provide clear evidence that the effect of hydrogen-air gas mixture temperature, in the range 300K to 650K, is to decrease cell size and, hence, to increase the sensitivity of the mixture to undergo detonations. The effect of steam content, at any given temperature, is to increase the cell size and, thereby, to decrease the sensitivity of stoichiometric hydrogen-air mixtures. The one-dimensional ZND model does a very good job at predicting the overall trends in the cell size data over the range of hydrogen-air-steam mixture compositions and temperature studied in the experiments. Experiments were conducted to measure the rate of hydrogen oxidation in the absence of ignition sources at temperatures of 500K and 650K, for hydrogen-air mixtures of 15% and 50%, and for a mixture of equimolar hydrogen-air and 30% steam at 650K. The rate of hydrogen oxidation was found to be significant at 650K. Reduction of hydrogen concentration by chemical reaction from 50 to 44% hydrogen, and from 15 to 11% hydrogen, were observed on a time frame of minutes. The DeSoete rate equation predicts the 50% experiment very well, but greatly underestimates the reaction rate of the lean mixtures

  13. Fault Wear and Friction Evolution: Experimental Analysis

    Science.gov (United States)

    Boneh, Y.; Chang, J. C.; Lockner, D. A.; Reches, Z.

    2011-12-01

    Wear is an inevitable product of frictional sliding of brittle rocks as evidenced by the ubiquitous occurrence of fault gouge and slickenside striations. We present here experimental observations designed to demonstrate the relationship between wear and friction and their governing mechanisms. The experiments were conducted with a rotary shear apparatus on solid, ring-shaped rock samples that slipped for displacements up to tens of meters. Stresses, wear and temperature were continuously monitored. We analyzed 86 experiments of Kasota dolomite, Sierra White granite, Pennsylvania quartzite, Karoo gabbro, and Tennessee sandstone at slip velocities ranging from 0.002 to 0.97 m/s, and normal stress from 0.25 to 6.9 MPa. We conducted two types of runs: short slip experiments (slip distance wear mechanisms; and long slip experiments (slip distance > 3 m) designed to achieve mature wear conditions and to observe the evolution of wear and friction as the fault surfaces evolved. The experiments reveal three wear stages: initial, running-in, and steady-state. The initial stage is characterized by (1) discrete damage striations, the length of which is comparable to total slip , and local pits or plow features; (2) timing and magnitude of fault-normal dilation corresponds to transient changes of normal and shear stresses; and (3) surface roughness increasing with the applied normal stress. We interpret these observations as wear mechanisms of (a) plowing into the fresh rock surfaces; (b) asperity breakage; and (c) asperity climb. The running-in stage is characterized by (1) intense wear-rate over a critical wear distance of Rd = 0.3-2 m; (2) drop of friction coefficient over a weakening distance of Dc = 0.2-4 m; (3) Rd and Dc display positive, quasi-linear relation with each other. We interpret these observations as indicating the organizing of newly-created wear particles into a 'three-body' structure that acts to lubricate the fault (Reches & Lockner, 2010). The steady

  14. The analysis of experimental data obtained from automotives tests

    Science.gov (United States)

    Stoica, R. M.; Radulescu, V. J.; Neagu, D.; Trocan, C.; Copae, I.

    2016-08-01

    The paper highlights the three important and inseparably aspects of the systemic approach of automotives dynamics: taking into account the human-vehicle-field interaction, dealing movement with algorithms specific to system theory and analysis of experimental data with algorithms specific to signals theory.Within the paper, the systemic approach regarding vehicles dynamics is based on experimental data obtained from tests, whereby it is analyzed the movement and there are obtained movement mathematical models through algorithms of systems identification.Likewise, there are shown main analysis methods for experimental data, which uses probability theory, information theory, correlation analysis and variance analysis;in addition, there are highlighted possibilities given by time analysis, frequency analysis and data time-frequency analysis. Identification algorithms and highlighted analysis procedures assure the study of automotives dynamics and fuel saving,by directly using experimental data, or by using mathematical models and applying concepts and algorithms specific to systems theory. Experimental data were obtained by testing automotives with electronic control devices and by using acquisition and storage equipmentsfor data given by the on-board computer and taken from embedded sensors.

  15. Functional and structural causes of forests productivity decay with age: experimental analysis of a chrono-sequence of maritime pine stands; Causes fonctionnelles et structurales du declin de productivite des forets avec l'age: analyse experimentale d'une chronosequence de peuplements de pin maritime

    Energy Technology Data Exchange (ETDEWEB)

    Delzon, S.

    2004-06-15

    The aim of this work was to understand the causes of forest growth decline with increasing age. We investigated changes in several eco-physiological parameters in a chrono-sequence of four even-aged maritime pine stands. Above-ground productivity declined by a factor of 2.5 from the youngest to the oldest stands. This decline was explained by a decrease of gross primary production, due to a decline in both stand leaf area and foliar productivity. Our measurements clearly showed a decrease in leaf-specific hydraulic conductance with increasing tree height (50% lower in 30 m trees than in 10 m trees). We also found that needle water potential was maintained above a minimum threshold value of -2.0 MPa independently of tree age and height. This hydraulic homeostasis occurred through a decline in leaf / sapwood area ratio (hydraulic compensation) and a decline in stomatal conductance (physiological compensation). Both the increased investment in non-productive versus productive tissues and stomatal closure may have contributed to the observed decrease in foliar productivity with increasing tree height. Consequently, over-storey transpiration was reduced by a factor of three between the 10-yr and the 91-yr old stands. Nevertheless, our findings suggest that the total ecosystem evaporation remains constant in ageing forests due to an increase in under-storey transpiration, which may counterbalance the decrease in tree transpiration. Photosynthetic capacity also decreased in older stands, mainly through a decline in phosphorus concentration. Our results support the hypothesis that the age-related decline in forest growth is associated with decreased availability of the most limiting resource, this being phosphorus for the maritime Pine chrono-sequence investigated. (author)

  16. AN EXPERIMENTAL ANALYSIS OF BACTERIAL ALLERGY.

    Science.gov (United States)

    Zinsser, H; Tamiya, T

    1926-11-30

    sensitive animals is not absolute and shows considerable overlapping. Continued treatment with considerable quantities of the above substances leads to gradual desensitization in animals in which there are no chronic foci present, which, as in tuberculosis, tends to continue the sensitization. Attempts at passive sensitization have been irregular and inconclusive. When any degree of sensitiveness has developed after the injection of immune sera, it has appeared late and has been of doubtful specificity. Conversely we have failed in any case to neutralize the activity of the active allergic constituents of bacterial extracts by incubation with any type of immune serum. We have failed so far to show any increased fixation of tuberculin material on the part of tuberculous tissues or on that of living tuberculous animals. These failures, however, seem to us of relatively slight importance since quantitative experiments of this nature are extremely difficult in the case of a substance as delicately potent for the tuberculous animal. On the other hand we have obtained definite, though irregular evidence that the incubation of O.T. with fragments of tuberculous lung tissue (less clearly with other tissues) leads to the formation of a substance that produces allergy-like lesions in the skin of normal guinea pigs. With somewhat greater regularity, similar treatment of O.T. has enhanced the potency of the tuberculin for tuberculous animals. And, in these experiments there was evidence that the factor responsible for this action was not easily separable from the cells themselves. When these experimental data are analytically considered they appear in many respects confusing and contradictory. There has been so much work done on the tuberculin reaction, moreover, that, in the face of experimental inconsistencies it would seem foolhardy to formulate more than tentative suggestions to explain the mechanism of these reactions. Nevertheless there are a few outstanding and sufficiently

  17. Age-dependent effects of UCP2 deficiency on experimental acute pancreatitis in mice.

    Directory of Open Access Journals (Sweden)

    Sarah Müller

    Full Text Available Reactive oxygen species (ROS have been implicated in the pathogenesis of acute pancreatitis (AP for many years but experimental evidence is still limited. Uncoupling protein 2 (UCP2-deficient mice are an accepted model of age-related oxidative stress. Here, we have analysed how UCP2 deficiency affects the severity of experimental AP in young and older mice (3 and 12 months old, respectively triggered by up to 7 injections of the secretagogue cerulein (50 μg/kg body weight at hourly intervals. Disease severity was assessed at time points from 3 hours to 7 days based on pancreatic histopathology, serum levels of alpha-amylase, intrapancreatic trypsin activation and levels of myeloperoxidase (MPO in lung and pancreatic tissue. Furthermore, in vitro studies with pancreatic acini were performed. At an age of 3 months, UCP2-/- mice and wild-type (WT C57BL/6 mice were virtually indistinguishable with respect to disease severity. In contrast, 12 months old UCP2-/- mice developed a more severe pancreatic damage than WT mice at late time points after the induction of AP (24 h and 7 days, respectively, suggesting retarded regeneration. Furthermore, a higher peak level of alpha-amylase activity and gradually increased MPO levels in pancreatic and lung tissue were observed in UCP2-/- mice. Interestingly, intrapancreatic trypsin activities (in vivo studies and intraacinar trypsin and elastase activation in response to cerulein treatment (in vitro studies were not enhanced but even diminished in the knockout strain. Finally, UCP2-/- mice displayed a diminished ratio of reduced and oxidized glutathione in serum but no increased ROS levels in pancreatic acini. Together, our data indicate an aggravating effect of UCP2 deficiency on the severity of experimental AP in older but not in young mice. We suggest that increased severity of AP in 12 months old UCP2-/- is caused by an imbalanced inflammatory response but is unrelated to acinar cell functions.

  18. Chain formation and aging process in biocompatible polydisperse ferrofluids: experimental investigation and Monte Carlo simulations.

    Science.gov (United States)

    Bakuzis, Andris Figueiroa; Branquinho, Luis César; e Castro, Leonardo Luiz; e Eloi, Marcos Tiago de Amaral; Miotto, Ronei

    2013-05-01

    We review the use of Monte Carlo simulations in the description of magnetic nanoparticles dispersed in a liquid carrier. Our main focus is the use of theory and simulation as tools for the description of the properties of ferrofluids. In particular, we report on the influence of polydispersity and short-range interaction on the self-organization of nanoparticles. Such contributions are shown to be extremely important for systems characterized by particles with diameters smaller than 10nm. A new 3D polydisperse Monte Carlo implementation for biocompatible magnetic colloids is proposed. As an example, theoretical and simulation results for an ionic-surfacted ferrofluid dispersed in a NaCl solution are directly compared to experimental data (transmission electron microscopy - TEM, magneto-transmissivity, and electron magnetic resonance - EMR). Our combined theoretical and experimental results suggest that during the aging process two possible mechanisms are likely to be observed: the nanoparticle's grafting decreases due to aggregate formation and the Hamaker constant increases due to oxidation. In addition, we also briefly discuss theoretical agglomerate formation models and compare them to experimental data. PMID:23360743

  19. Transparent meta-analysis of prospective memory and aging.

    Directory of Open Access Journals (Sweden)

    Bob Uttl

    Full Text Available Prospective memory (ProM refers to our ability to become aware of a previously formed plan at the right time and place. After two decades of research on prospective memory and aging, narrative reviews and summaries have arrived at widely different conclusions. One view is that prospective memory shows large age declines, larger than age declines on retrospective memory (RetM. Another view is that prospective memory is an exception to age declines and remains invariant across the adult lifespan. The present meta-analysis of over twenty years of research settles this controversy. It shows that prospective memory declines with aging and that the magnitude of age decline varies by prospective memory subdomain (vigilance, prospective memory proper, habitual prospective memory as well as test setting (laboratory, natural. Moreover, this meta-analysis demonstrates that previous claims of no age declines in prospective memory are artifacts of methodological and conceptual issues afflicting prior research including widespread ceiling effects, low statistical power, age confounds, and failure to distinguish between various subdomains of prospective memory (e.g., vigilance and prospective memory proper.

  20. Determination of equivalent breast phantoms for different age groups of Taiwanese women: An experimental approach

    Energy Technology Data Exchange (ETDEWEB)

    Dong, Shang-Lung; Chu, Tieh-Chi; Lin, Yung-Chien; Lan, Gong-Yau; Yeh, Yu-Hsiu; Chen, Sharon; Chuang, Keh-Shih [Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101 Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan (China); Department of Radiology, Cheng Hsin General Hospital, 45 Cheng Hsin Street, Pai-Tou District, Taipei 11220, Taiwan (China); Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan (China); Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101 Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan (China)

    2011-07-15

    Purpose: Polymethylmethacrylate (PMMA) slab is one of the mostly used phantoms for studying breast dosimetry in mammography. The purpose of this study was to evaluate the equivalence between exposure factors acquired from PMMA slabs and patient cases of different age groups of Taiwanese women in mammography. Methods: This study included 3910 craniocaudal screen/film mammograms on Taiwanese women acquired on one mammographic unit. The tube loading, compressed breast thickness (CBT), compression force, tube voltage, and target/filter combination for each mammogram were collected for all patients. The glandularity and the equivalent thickness of PMMA were determined for each breast using the exposure factors of the breast in combination with experimental measurements from breast-tissue-equivalent attenuation slabs. Equivalent thicknesses of PMMA to the breasts of Taiwanese women were then estimated. Results: The average {+-} standard deviation CBT and breast glandularity in this study were 4.2 {+-} 1.0 cm and 54% {+-} 23%, respectively. The average equivalent PMMA thickness was 4.0 {+-} 0.7 cm. PMMA slabs producing equivalent exposure factors as in the breasts of Taiwanese women were determined for the age groups 30-49 yr and 50-69 yr. For the 4-cm PMMA slab, the CBT and glandularity values of the equivalent breast were 4.1 cm and 65%, respectively, for the age group 30-49 yr and 4.4 cm and 44%, respectively, for the age group 50-69 yr. Conclusions: The average thickness of PMMA slabs producing the same exposure factors as observed in a large group of Taiwanese women is less than that reported for American women. The results from this study can provide useful information for determining a suitable thickness of PMMA for mammographic dose survey in Taiwan. The equivalence of PMMA slabs and the breasts of Taiwanese women is provided to allow average glandular dose assessment in clinical practice.

  1. Experimental Modal Analysis of a Flat Plate Subjected To Vibration

    Directory of Open Access Journals (Sweden)

    Owunna Ikechukwu

    2016-07-01

    Full Text Available Modal analysis is significant in evaluating the mode shapes generated by a component under vibrational excitation, as the mode shapes can be used to determine the displacement or response of the component under the influence vibration in real life application. Result obtained from the modal analysis will generate a number of resonances which the frequency and damping effect can be determined by measurement. However, determining the accuracy of modal analysis result is somewhat difficult as the experimental results and the results generated by Finite Element Analysis (FEA solvers can be affected by a number of factors pointed out in this paper. In this study, a flat plate was mounted on an electromagnetic shaker which enabled the excitation of the plate, while results of the response were measured using a transducer attached to the plate. The plate was also modelled using CATIA software and the files transferred to the different FEA solvers such as HYPERMESH, ANSYS 6 Degree of Freedom (DOF as well as ANSYS 5 degree of freedom, in which the same analysis was carried out to obtain a set of results other than the experimental results. Each FEA solver generated results that were in close proximity with the experimental results, particularly the results generated by ANSYS 5 Degree of freedom. Hence, to ascertain the accuracy of the results obtained from modal analysis experimental procedure, it is important to match up the results generated from different FEA solvers with the experimental results.

  2. Aging Chart: a community resource for rapid exploratory pathway analysis of age-related processes.

    Science.gov (United States)

    Moskalev, Alexey; Zhikrivetskaya, Svetlana; Shaposhnikov, Mikhail; Dobrovolskaya, Evgenia; Gurinovich, Roman; Kuryan, Oleg; Pashuk, Aleksandr; Jellen, Leslie C; Aliper, Alex; Peregudov, Alex; Zhavoronkov, Alex

    2016-01-01

    Aging research is a multi-disciplinary field encompassing knowledge from many areas of basic, applied and clinical research. Age-related processes occur on molecular, cellular, tissue, organ, system, organismal and even psychological levels, trigger the onset of multiple debilitating diseases and lead to a loss of function, and there is a need for a unified knowledge repository designed to track, analyze and visualize the cause and effect relationships and interactions between the many elements and processes on all levels. Aging Chart (http://agingchart.org/) is a new, community-curated collection of aging pathways and knowledge that provides a platform for rapid exploratory analysis. Building on an initial content base constructed by a team of experts from peer-reviewed literature, users can integrate new data into biological pathway diagrams for a visible, intuitive, top-down framework of aging processes that fosters knowledge-building and collaboration. As the body of knowledge in aging research is rapidly increasing, an open visual encyclopedia of aging processes will be useful to both the new entrants and experts in the field. PMID:26602690

  3. Evaluation of Experimental Parameters in the Accelerated Aging of Closed-Cell Foam Insulation

    Energy Technology Data Exchange (ETDEWEB)

    Stovall, Therese K [ORNL; Vanderlan, Michael [ORNL; Atchley, Jerald Allen [ORNL

    2012-12-01

    The thermal conductivity of many closed-cell foam insulation products changes over time as production gases diffuse out of the cell matrix and atmospheric gases diffuse into the cells. Thin slicing has been shown to be an effective means of accelerating this process in such a way as to produce meaningful results. Efforts to produce a more prescriptive version of the ASTM C1303 standard test method led to the ruggedness test described here. This test program included the aging of full size insulation specimens for time periods of five years for direct comparison to the predicted results. Experimental parameters under investigation include: slice thickness, slice origin (at the surface or from the core of the slab), thin slice stack composition, product facings, original product thickness, product density, and product type. The test protocol has been completed and this report provides a detailed evaluation of the impact of the test parameters on the accuracy of the 5-year thermal conductivity prediction.

  4. Applications of Digital Image Analysis in Experimental Mechanics

    OpenAIRE

    Lyngbye, J. : Ph.D.

    1992-01-01

    The present thesis "Application of Digital Image Analysis in Experimental Mechanics" has been prepared as a part of Janus Lyngbyes Ph.D. study during the period December 1988 to June 1992 at the Department of Building technology and Structural Engineering, University of Aalborg, Denmark. In this thesis attention will be focused on optimal use and analysis of the information of digital images. This is realized during investigation and application of parametric methods in digital image analysis...

  5. Experimental and theoretical analysis of cracking in drying soils

    OpenAIRE

    Lakshmikantha, M.R.

    2009-01-01

    The thesis focuses on the experimental and theoretical aspects of the process of cracking in drying soils. The results and conclusions were drawn from an exhaustive experimental campaign characterised by innovative multidisciplinary aspects incorporating Fracture Mechanics and classical Soil mechanics, aided with image analysis techniques. A detailed study of the previous works on the topic showed the absence of large scale fully monitored laboratory tests, while the existing studies were per...

  6. Effects of ageing and experimental diabetes on insulin-degrading enzyme expression in male rat tissues.

    Science.gov (United States)

    Kochkina, Ekaterina G; Plesneva, Svetlana A; Vasilev, Dmitrii S; Zhuravin, Igor A; Turner, Anthony J; Nalivaeva, Natalia N

    2015-08-01

    Due to an increasing life expectancy in developing countries, cases of type 2 diabetes and Alzheimer's disease (AD) in the elderly are growing exponentially. Despite a causative link between diabetes and AD, general molecular mechanisms underlying pathogenesis of these disorders are still far from being understood. One of the factors leading to cell death and cognitive impairment characteristic of AD is accumulation in the brain of toxic aggregates of amyloid-β peptide (Aβ). In the normally functioning brain Aβ catabolism is regulated by a cohort of proteolytic enzymes including insulin-degrading enzyme (IDE) and their deficit with ageing can result in Aβ accumulation and increased risk of AD. The aim of this study was a comparative analysis of IDE expression in the brain structures involved in AD, as well as in peripheral organs (the liver and kidney) of rats, during natural ageing and after experimentally-induced diabetes. It was found that ageing is accompanied by a significant decrease of IDE mRNA and protein content in the liver (by 32 and 81%) and brain structures (in the cortex by 58 and 47% and in the striatum by 53 and 68%, respectively). In diabetic animals, IDE protein level was increased in the liver (by 36%) and in the striatum (by 42%) while in the brain cortex and hippocampus it was 20-30% lower than in control animals. No significant IDE protein changes were observed in the kidney of diabetic rats. These data testify that ageing and diabetes are accompanied by a deficit of IDE in the brain structures where accumulation of Aβ was reported in AD patients, which might be one of the factors predisposing to development of the sporadic form of AD in the elderly, and especially in diabetics.

  7. The influence of age and genetics on natural resistance to experimentally induced feline infectious peritonitis.

    Science.gov (United States)

    Pedersen, Niels C; Liu, Hongwei; Gandolfi, Barbara; Lyons, Leslie A

    2014-11-15

    Naturally occurring feline infectious peritonitis (FIP) is usually fatal, giving the impression that immunity to the FIP virus (FIPV) is extremely poor. This impression may be incorrect, because not all cats experimentally exposed to FIPV develop FIP. There is also a belief that the incidence of FIP may be affected by a number of host, virus, and environmental cofactors. However, the contribution of these cofactors to immunity and disease incidence has not been determined. The present study followed 111 random-bred specific pathogen free (SPF) cats that were obtained from a single research breeding colony and experimentally infected with FIPV. The cats were from several studies conducted over the past 5 years, and as a result, some of them had prior exposure to feline enteric coronavirus (FECV) or avirulent FIPVs. The cats were housed under optimized conditions of nutrition, husbandry, and quarantine to eliminate most of the cofactors implicated in FIPV infection outcome and were uniformly challenge exposed to the same field strain of serotype 1 FIPV. Forty of the 111 (36%) cats survived their initial challenge exposure to a Type I cat-passaged field strains of FIPV. Six of these 40 survivors succumbed to FIP to a second or third challenge exposure, suggesting that immunity was not always sustained. Exposure to non-FIP-inducing feline coronaviruses prior to challenge with virulent FIPV did not significantly affect FIP incidence but did accelerate the disease course in some cats. There were no significant differences in FIP incidence between males and females, but resistance increased significantly between 6 months and 1 or more years of age. Genetic testing was done on 107 of the 111 infected cats. Multidimensional scaling (MDS) segregated the 107 cats into three distinct families based primarily on a common sire(s), and resistant and susceptible cats were equally distributed within each family. Genome-wide association studies (GWAS) on 73 cats that died of FIP

  8. The influence of age and genetics on natural resistance to experimentally induced feline infectious peritonitis.

    Science.gov (United States)

    Pedersen, Niels C; Liu, Hongwei; Gandolfi, Barbara; Lyons, Leslie A

    2014-11-15

    Naturally occurring feline infectious peritonitis (FIP) is usually fatal, giving the impression that immunity to the FIP virus (FIPV) is extremely poor. This impression may be incorrect, because not all cats experimentally exposed to FIPV develop FIP. There is also a belief that the incidence of FIP may be affected by a number of host, virus, and environmental cofactors. However, the contribution of these cofactors to immunity and disease incidence has not been determined. The present study followed 111 random-bred specific pathogen free (SPF) cats that were obtained from a single research breeding colony and experimentally infected with FIPV. The cats were from several studies conducted over the past 5 years, and as a result, some of them had prior exposure to feline enteric coronavirus (FECV) or avirulent FIPVs. The cats were housed under optimized conditions of nutrition, husbandry, and quarantine to eliminate most of the cofactors implicated in FIPV infection outcome and were uniformly challenge exposed to the same field strain of serotype 1 FIPV. Forty of the 111 (36%) cats survived their initial challenge exposure to a Type I cat-passaged field strains of FIPV. Six of these 40 survivors succumbed to FIP to a second or third challenge exposure, suggesting that immunity was not always sustained. Exposure to non-FIP-inducing feline coronaviruses prior to challenge with virulent FIPV did not significantly affect FIP incidence but did accelerate the disease course in some cats. There were no significant differences in FIP incidence between males and females, but resistance increased significantly between 6 months and 1 or more years of age. Genetic testing was done on 107 of the 111 infected cats. Multidimensional scaling (MDS) segregated the 107 cats into three distinct families based primarily on a common sire(s), and resistant and susceptible cats were equally distributed within each family. Genome-wide association studies (GWAS) on 73 cats that died of FIP

  9. VIRTUAL EXPERIMENTAL ANALYSIS ON CLEANING ELEMENT OF SUGARCANE HARVESTER

    Institute of Scientific and Technical Information of China (English)

    Ma Fanglan; Li Shangping; He Yulin; Meng Yanmei; Chen Weixu

    2005-01-01

    The laws of influence of different factors have been analyzed in order to enhance the working efficiency and fatigue life of the cleaning element in brush shape of the sugarcane harvester.Based on the principle of orthogonal experiment design, the virtual-orthogonal-experimental analysis for the cleaning element is carried out on the finite element analysis (FEA) software-ANSYS after analyzing the nonlinear structural behavior in the working procedure. The results are analyzed with the overall balancing method, and then the optimal combination is got, which is made up of different levels of different factors. Also the optimal combination of design parameters of the cleaning element received from the virtual experimental analysis is conducted an experiment to confirm that the virtual analysis model and results are right, and the effect of factors on the function of the cleaning element is obtained by more analysis and further optimizing.

  10. Effect of Cistanche Desertica Polysaccharides on Learning and Memory Functions and Ultrastructure of Cerebral Neurons in Experimental Aging Mice

    Institute of Scientific and Technical Information of China (English)

    孙云; 邓杨梅; 王德俊; 沈春锋; 刘晓梅; 张洪泉

    2001-01-01

    To observe the effects of Cistanche desertica polysaccharides (CDP) on the learning and memory functions and cerebral ultrastructure in experimental aging mice. Methods: CDP was administrated intragastrically 50 or 100 mg/kg per day for 64 successive days to experimental aging model mice induced by D-galactose, then the learning and memory functions of mice were estimated by step-down test and Y-maze test; organelles of brain tissue and cerebral ultrastructure were observed by transmission electron microscope and physical strength was determined by swimming test. Results: CDP could obviously enhance the learning and memory functions (P<0.01) and prolong the swimming time (P<0.05), decrease the number of lipofuscin and slow down the degeneration of mitochondria in neurons(P<0.05), and improve the degeneration of cerebral ultra-structure in aging mice. Conclusion: CDP could improve the impaired physiological function and alleviate cerebral morphological change in experimental aging mice.

  11. Evaluating experimental bias and completeness in comparative phosphoproteomics analysis.

    Directory of Open Access Journals (Sweden)

    Jos Boekhorst

    Full Text Available Unraveling the functional dynamics of phosphorylation networks is a crucial step in understanding the way in which biological networks form a living cell. Recently there has been an enormous increase in the number of measured phosphorylation events. Nevertheless, comparative and integrative analysis of phosphoproteomes is confounded by incomplete coverage and biases introduced by different experimental workflows. As a result, we cannot differentiate whether phosphosites indentified in only one or two samples are the result of condition or species specific phosphorylation, or reflect missing data. Here, we evaluate the impact of incomplete phosphoproteomics datasets on comparative analysis, and we present bioinformatics strategies to quantify the impact of different experimental workflows on measured phosphoproteomes. We show that plotting the saturation in observed phosphosites in replicates provides a reproducible picture of the extent of a particular phosphoproteome. Still, we are still far away from a complete picture of the total human phosphoproteome. The impact of different experimental techniques on the similarity between phosphoproteomes can be estimated by comparing datasets from different experimental pipelines to a common reference. Our results show that comparative analysis is most powerful when datasets have been generated using the same experimental workflow. We show this experimentally by measuring the tyrosine phosphoproteome from Caenorhabditis elegans and comparing it to the tyrosine phosphoproteome of HeLa cells, resulting in an overlap of about 4%. This overlap between very different organisms represents a three-fold increase when compared to dataset of older studies, wherein different workflows were used. The strategies we suggest enable an estimation of the impact of differences in experimental workflows on the overlap between datasets. This will allow us to perform comparative analyses not only on datasets specifically

  12. Demographic analysis from summaries of an age-structured population

    Science.gov (United States)

    Link, W.A.; Royle, J. Andrew; Hatfield, J.S.

    2003-01-01

    Demographic analyses of age-structured populations typically rely on life history data for individuals, or when individual animals are not identified, on information about the numbers of individuals in each age class through time. While it is usually difficult to determine the age class of a randomly encountered individual, it is often the case that the individual can be readily and reliably assigned to one of a set of age classes. For example, it is often possible to distinguish first-year from older birds. In such cases, the population age structure can be regarded as a latent variable governed by a process prior, and the data as summaries of this latent structure. In this article, we consider the problem of uncovering the latent structure and estimating process parameters from summaries of age class information. We present a demographic analysis for the critically endangered migratory population of whooping cranes (Grus americana), based only on counts of first-year birds and of older birds. We estimate age and year-specific survival rates. We address the controversial issue of whether management action on the breeding grounds has influenced recruitment, relating recruitment rates to the number of seventh-year and older birds, and examining the pattern of variation through time in this rate.

  13. Viscoplastic analysis of an experimental cylindrical thrust chamber liner

    Science.gov (United States)

    Arya, Vinod K.; Arnold, Steven M.

    1992-01-01

    A viscoplastic stress-strain analysis of an experimental cylindrical thrust chamber is presented. A viscoelastic constitutive model incorporating a single internal state variable that represents kinematic hardening was employed to investigate whether such a viscoplastic model could predict the experimentally observed behavior of the thrust chamber. Two types of loading cycles were considered: a short cycle of 3.5-s duration that corresponded to the experiments, and an extended loading cycle of 485.1 s duration that is typical of the Space Shuttle Main Engine (SSME) operating cycle. The analysis qualitatively replicated the deformation behavior of the component as observed in experiments designed to simulate SSME operating conditions. The analysis also showed that the mode and location of failure in the component may depend on the loading cycle. The results indicate that using viscoplastic models for structural analysis can lead to a more realistic life assessment of thrust chambers.

  14. Inductive Logic From Data Analysis to Experimental Design

    CERN Document Server

    Knuth, K H

    2002-01-01

    In celebration of the work of Richard Threlkeld Cox, we explore inductive logic and its role in science touching on both experimental design and analysis of experimental results. In this exploration we demonstrate that the duality between the logic of assertions and the logic of questions has important consequences. We discuss the conjecture that the relevance or bearing, b, of a question on an issue can be expressed in terms of the probabilities, p, of the assertions that answer the question via the entropy. In its application to the scientific method, the logic of questions, inductive inquiry, can be applied to design an experiment that most effectively addresses a scientific issue. This is performed by maximizing the relevance of the experimental question to the scientific issue to be resolved. It is shown that these results are related to the mutual information between the experiment and the scientific issue, and that experimental design is akin to designing a communication channel that most efficiently c...

  15. Experimentally Validated Nonlinear Analysis of Bridge Plate Girders with Deformations

    Directory of Open Access Journals (Sweden)

    Kużawa Mieszko

    2015-09-01

    Full Text Available Comprehensive methodology of numerical nonlinear analysis of the consecutive phases in the structural behaviour of bridge plate girders with deformations is presented. The analysis concerns all stages of structure loading until failure and especially determination of the ultimate shear load capacity. Verification and validation of the numerical procedures proposed is based on comparison of the calculated results with effects of experimental laboratory shear capacity tests of plate girders carried out at the University of Ljubljana.

  16. Kinematic Analysis and Experimental Verification on the Locomotion of Gecko

    Institute of Scientific and Technical Information of China (English)

    Woochul Nam; TaeWon Seo; Byungwook Kim; Dongsu Jeon; Kyu-Jin Cho; Jongwon Kim

    2009-01-01

    This paper presents a kinematic analysis of the locomotion of a gecko, and experimental verification of the kinematic model. Kinematic analysis is important for parameter design, dynamic analysis, and optimization in biomimetic robot research. The proposed kinematic analysis can simulate, without iteration, the locomotion of gecko satisfying the constraint conditions that maintain the position of the contacted feet on the surface. So the method has an advantage for analyzing the climbing motion of the quadruped mechanism in a real time application. The kinematic model of a gecko consists of four legs based on 7-degrees of freedom spherical-revolute-spherical joints and two revolute joints in the waist. The motion of the kinematic model is simulated based on measurement data of each joint. The motion of the kinematic model simulates the investigated real gecko's motion by using the experimental results. The analysis solves the forward kinematics by considering the model as a combination of closed and open serial mechanisms under the condition that maintains the contact positions of the attached feet on the ground. The motions of each joint are validated by comparing with the experimental results. In addition to the measured gait, three other gaits are simulated based on the kinematic model. The maximum strides of each gait are calculated by workspace analysis. The result can be used in biomimetic robot design and motion planning.

  17. Experimental Data and Geometric Analysis Repository-EDGAR

    NARCIS (Netherlands)

    Aras, K.; Good, W.; Tate, J.; Burton, B.; Brooks, D.; Coll-Font, J.; Doessel, O.; Schulze, W.; Potyagaylo, D.; Wang, L.; Dam, P.M. van; MacLeod, R.

    2015-01-01

    INTRODUCTION: The "Experimental Data and Geometric Analysis Repository", or EDGAR is an Internet-based archive of curated data that are freely distributed to the international research community for the application and validation of electrocardiographic imaging (ECGI) techniques. The EDGAR project i

  18. Elevation of cartilage AGEs does not accelerate initiation of canine experimental osteoarthritis upon mild surgical damage

    NARCIS (Netherlands)

    Vos, P.A.J.M.; Degroot, J.; Barten-Van Rijbroek, A.D.; Zuurmond, A.-M.; Bijlsma, J.W.J.; Mastbergen, S.C.; Lafeber, F.P.J.G.

    2012-01-01

    Osteoarthritis is a highly prevalent disease, age being the main risk factor. The age-related accumulation of advanced-glycation-endproducts (AGEs) adversely affects the mechanical and biochemical properties of cartilage. The hypothesis that accumulation of cartilage AGEs in combination with surgica

  19. Aging Analysis of Micromegas Detectors for ATLAS New Small Wheel

    CERN Document Server

    Quinnan, Melissa

    2015-01-01

    In preparation for the coming High Luminosity Large Hadron Collider (HL-LHC) upgrade, the New Small Wheel (NSW) will replace the Small Wheel of the ATLAS Muon Spectrometer as part of the 2018 ATLAS Phase-I upgrade. Micromegas (MM) detectors will serve as one component of the NSW. These gaseous micro-mesh detectors will accommodate the higher luminosity and trigger rate of the future HL-LHC.In order to predict performance of MM after several years in the HL-LHC, radiation aging tests were conducted in the Gamma Irradiation Facility (GIF++) using a Cs 137 source. Two small MM prototype "T" chambers were irradiated and studied over the course of several months to accelerate the aging process and characterize chamber behavior. This report outlines a record of the aging process thus far and demonstrates techniques used to describe aging effects, namely measurements of average current, integrated charge, and gain. These will be used in the ongoing aging analysis of the T chambers and in future aging studies of the ...

  20. Probabilistic methods in nuclear power plant component ageing analysis

    International Nuclear Information System (INIS)

    The nuclear power plant ageing research is aimed to ensure that the plant safety and reliability are maintained at a desired level through the designed, and possibly extended lifetime. In ageing studies, the reliability of components, systems and structures is evaluated taking into account the possible time- dependent decrease in reliability. The results of analyses can be used in the evaluation of the remaining lifetime of components and in the development of preventive maintenance, testing and replacement programmes. The report discusses the use of probabilistic models in the evaluations of the ageing of nuclear power plant components. The principles of nuclear power plant ageing studies are described and examples of ageing management programmes in foreign countries are given. The use of time-dependent probabilistic models to evaluate the ageing of various components and structures is described and the application of models is demonstrated with two case studies. In the case study of motor- operated closing valves the analysis are based on failure data obtained from a power plant. In the second example, the environmentally assisted crack growth is modelled with a computer code developed in United States, and the applicability of the model is evaluated on the basis of operating experience

  1. An Experimental Metagenome Data Management and AnalysisSystem

    Energy Technology Data Exchange (ETDEWEB)

    Markowitz, Victor M.; Korzeniewski, Frank; Palaniappan, Krishna; Szeto, Ernest; Ivanova, Natalia N.; Kyrpides, Nikos C.; Hugenholtz, Philip

    2006-03-01

    The application of shotgun sequencing to environmental samples has revealed a new universe of microbial community genomes (metagenomes) involving previously uncultured organisms. Metagenome analysis, which is expected to provide a comprehensive picture of the gene functions and metabolic capacity of microbial community, needs to be conducted in the context of a comprehensive data management and analysis system. We present in this paper IMG/M, an experimental metagenome data management and analysis system that is based on the Integrated Microbial Genomes (IMG) system. IMG/M provides tools and viewers for analyzing both metagenomes and isolate genomes individually or in a comparative context.

  2. Exergy analysis of an experimental heat transformer for water purification

    International Nuclear Information System (INIS)

    First and second law of thermodynamics have been used to analyze the performance of an experimental heat transformer used for water purification. The pure water is produced in the auxiliary condenser delivering an amount of heat, which is recycled into the heat transformer increasing the heat source temperatures and also the internal, external and exergy coefficients of performance. The theoretical and experimental study was divided into two parts. In the first part, a second law analysis was carried out to the experimental system showing that the absorber and the condenser are the components with the highest irreversibilities. In the second part, with the results obtained from the second law analysis, new test runs were carried out at similar conditions than the former but varying only one selected temperature at the time. Comparing the COP (coefficient of performance) between the old and new test runs, it was shown that higher internal, external and exergy coefficients of performance were obtained in all the new test runs. Also it was shown that the ECOP (exergy coefficient of performance) increases with an increment of the amount of the purified water produced and with the decrease of the flow ratio. -- Research highlights: → By the first time an experimental results of a heat transformer for water purification with heat recycling has been presented. → An exergy analysis has been carried out in order to identify the irreversibilities in the main components of the system. → With the results obtained of the second law analysis new experimental test runs were carried out minimizing the system irreversibilities and furthermore increasing the system efficiency.

  3. Experimental design and analysis for accelerated degradation tests with Li-ion cells.

    Energy Technology Data Exchange (ETDEWEB)

    Doughty, Daniel Harvey; Thomas, Edward Victor; Jungst, Rudolph George; Roth, Emanuel Peter

    2003-08-01

    This document describes a general protocol (involving both experimental and data analytic aspects) that is designed to be a roadmap for rapidly obtaining a useful assessment of the average lifetime (at some specified use conditions) that might be expected from cells of a particular design. The proposed experimental protocol involves a series of accelerated degradation experiments. Through the acquisition of degradation data over time specified by the experimental protocol, an unambiguous assessment of the effects of accelerating factors (e.g., temperature and state of charge) on various measures of the health of a cell (e.g., power fade and capacity fade) will result. In order to assess cell lifetime, it is necessary to develop a model that accurately predicts degradation over a range of the experimental factors. In general, it is difficult to specify an appropriate model form without some preliminary analysis of the data. Nevertheless, assuming that the aging phenomenon relates to a chemical reaction with simple first-order rate kinetics, a data analysis protocol is also provided to construct a useful model that relates performance degradation to the levels of the accelerating factors. This model can then be used to make an accurate assessment of the average cell lifetime. The proposed experimental and data analysis protocols are illustrated with a case study involving the effects of accelerated aging on the power output from Gen-2 cells. For this case study, inadequacies of the simple first-order kinetics model were observed. However, a more complex model allowing for the effects of two concurrent mechanisms provided an accurate representation of the experimental data.

  4. Experimental analysis of a joint free space cryptosystem

    Science.gov (United States)

    Ramírez, John Fredy Barrera; Osorio, Alexis Jaramillo; Zea, Alejandro Vélez; Torroba, Roberto

    2016-08-01

    In this paper, we analyze a joint free space cryptosystem scheme implemented in an actual laboratory environment. In this encrypting architecture, the object to be encoded and the security key are placed side by side in the input plane without optical elements between the input and the output planes. In order to get the encrypted information, the joint Fresnel power distribution JFPD coming from the input plane is registered in a CMOS camera. The information of the encrypting key is registered with an off axis Fresnel holographic setup. The data registered with the experimental setup is digitally filtered to obtain the encrypted object and the encryption key. In addition, we explore the performance of the experimental system as a function of the object-camera and key-camera distances, which are two new parameters of interest. These parameters become available as a result of developing this encrypting scheme. The theoretical and experimental analysis shows the validity and applicability of the cryptosystem.

  5. Analysis of surface hardness of artificially aged resin composites

    Directory of Open Access Journals (Sweden)

    Denise Cremonezzi Tornavoi

    2012-02-01

    Full Text Available This study evaluated the effect of artificially accelerated aging (AAA on the surface hardness of eight composite resins: Filtek Z250, Filtek Supreme, 4 Seasons, Herculite, P60, Tetric Ceram, Charisma, and Filtek Z100. Sixteen specimens were made from the test piece of each material, using an 8.0 × 2.0 mm teflon matrix. After 24 hours, eight specimens from each material were submitted to three surface hardness readings using a Shimadzu Microhardness Tester for 5 seconds at a load of 50 gf. The other eight specimens remained in the artificially accelerated aging machine for 382 hours and were submitted to the same surface hardness analysis. The means of each test specimen were submitted to the Kolmogorov-Smirnov test (p > 0.05, ANOVA and Tukey test (p < 0.05. With regard to hardness (F = 86.74, p < 0.0001 the analysis showed significant differences among the resin composite brands. But aging did not influence the hardness of any of the resin composites (F = 0.39, p = 0.53. In this study, there was interaction between the resin composite brand and the aging factors (F = 4.51, p < 0.0002. It was concluded that notwithstanding the type of resin, AAA did not influence surface hardness. However, with regard to hardness there was a significant difference among the resin brands.

  6. Experimental evidence against the mitochondrial theory of aging - A study of isolated human skeletal muscle mitochondria

    DEFF Research Database (Denmark)

    Rasmussen, Ulla Fugmann; Krustrup, Peter; Kjær, Michael;

    2003-01-01

    age effects, ATP formation, BSA effects, collagen content, low temperature spectroscopy, oxygen uptakes, quadriceps muscle, respiration, specific enzyme activities......age effects, ATP formation, BSA effects, collagen content, low temperature spectroscopy, oxygen uptakes, quadriceps muscle, respiration, specific enzyme activities...

  7. Renoprotective effects of the AGE-inhibitor pyridoxamine in experimental chronic allograft nephropathy in rats

    NARCIS (Netherlands)

    Waanders, Femke; van den Berg, Else; Nagai, Ryoji; van Veen, Ingrid; Navis, Gerjan; van Goor, Harry

    2008-01-01

    Background. Advanced glycation end products (AGEs) are involved in diabetic nephropathy (DN). The AGE formation inhibitor pyridoxamine (PM) is renoprotective in DN and in normoglycaemic obese Zucker rats. In chronic allograft nephropathy (CAN), renal AGE accumulation occurs as well. Methods. To inve

  8. The attitudes to ageing questionnaire: Mokken scaling analysis.

    Directory of Open Access Journals (Sweden)

    Susan D Shenkin

    Full Text Available BACKGROUND: Hierarchical scales are useful in understanding the structure of underlying latent traits in many questionnaires. The Attitudes to Ageing Questionnaire (AAQ explored the attitudes to ageing of older people themselves, and originally described three distinct subscales: (1 Psychosocial Loss (2 Physical Change and (3 Psychological Growth. This study aimed to use Mokken analysis, a method of Item Response Theory, to test for hierarchies within the AAQ and to explore how these relate to underlying latent traits. METHODS: Participants in a longitudinal cohort study, the Lothian Birth Cohort 1936, completed a cross-sectional postal survey. Data from 802 participants were analysed using Mokken Scaling analysis. These results were compared with factor analysis using exploratory structural equation modelling. RESULTS: Participants were 51.6% male, mean age 74.0 years (SD 0.28. Three scales were identified from 18 of the 24 items: two weak Mokken scales and one moderate Mokken scale. (1 'Vitality' contained a combination of items from all three previously determined factors of the AAQ, with a hierarchy from physical to psychosocial; (2 'Legacy' contained items exclusively from the Psychological Growth scale, with a hierarchy from individual contributions to passing things on; (3 'Exclusion' contained items from the Psychosocial Loss scale, with a hierarchy from general to specific instances. All of the scales were reliable and statistically significant with 'Legacy' showing invariant item ordering. The scales correlate as expected with personality, anxiety and depression. Exploratory SEM mostly confirmed the original factor structure. CONCLUSIONS: The concurrent use of factor analysis and Mokken scaling provides additional information about the AAQ. The previously-described factor structure is mostly confirmed. Mokken scaling identifies a new factor relating to vitality, and a hierarchy of responses within three separate scales, referring to

  9. SiSn diodes: Theoretical analysis and experimental verification

    KAUST Repository

    Hussain, Aftab M.

    2015-08-24

    We report a theoretical analysis and experimental verification of change in band gap of silicon lattice due to the incorporation of tin (Sn). We formed SiSn ultra-thin film on the top surface of a 4 in. silicon wafer using thermal diffusion of Sn. We report a reduction of 0.1 V in the average built-in potential, and a reduction of 0.2 V in the average reverse bias breakdown voltage, as measured across the substrate. These reductions indicate that the band gap of the silicon lattice has been reduced due to the incorporation of Sn, as expected from the theoretical analysis. We report the experimentally calculated band gap of SiSn to be 1.11 ± 0.09 eV. This low-cost, CMOS compatible, and scalable process offers a unique opportunity to tune the band gap of silicon for specific applications.

  10. Numerical - experimental approach to the S.S.I. analysis

    International Nuclear Information System (INIS)

    This paper describes forced excitation tests carried out on the PEC fast reactor building as well as several aspects of a complete 3D seismic response analysis. These studies focus on the soil-structure interaction problems. They have been performed by both mathematical procedures and processing of on-site experimental data. The mathematical models have been calibrated using the data obtained through the mentioned on site experimental dynamic tests on the reactor building, in order to develop a very reliable numerical model to compute the vibration levels induced by the design earthquakes and near-field earthquakes on the components and the building itself. In this way, the safety margins of the design analysis, carried out by use of simplified methods, are estimated

  11. Synergistic effect of estradiol and fluoxetine in young adult and middle-aged female rats in two models of experimental depression.

    Science.gov (United States)

    Récamier-Carballo, Soledad; Estrada-Camarena, Erika; Reyes, Rebeca; Fernández-Guasti, Alonso

    2012-08-01

    The antidepressant effect of estrogens combined with antidepressants is controversial: some preclinical data showed that estrogens facilitate the effect of antidepressants in the forced swimming test (FST) in young adult rats, while others failed to find such effect in middle-aged rats in the chronic mild stress (CMS) model. In clinics similar differences were reported and may be due to the compounds, the depression model or type of depression, the experimental design, and the age of the subjects or the women's menopause stage. The objective of this study was to analyze the antidepressant-like effect of the combination of 17β-estradiol (E(2)) and fluoxetine (FLX) in young adults (2-4 months) and middle-aged (12-14 months) ovariectomized (OVX) rats in two experimental models: FST and CMS. E(2) (5 and 10 μg/rat) and FLX (2.5 and 10 mg/kg) per se dose-dependently reduced immobility in both age groups and, in young adults both compounds increased swimming, whereas in middle-aged rats they increased swimming and climbing. Analysis of the antidepressant-like effect of the combination of suboptimal doses of FLX (1.25 mg/kg) and E(2) (2.5 μg/rat) showed a decrease in immobility and an increase in swimming in both age groups. In the CMS, chronic E(2) (2.5 μg/rat) with FLX (1.25 mg/kg) augmented relative sucrose intake, but middle-aged rats responded 2 weeks earlier than young adults. These results show that the antidepressant-like effect of the combination of E(2) and FLX in young adult and middle-aged female rats is evidenced in the two animal models of depression: FST and CMS.

  12. Experimental and Numerical Analysis of Spalling Effect in TRC Specimens

    OpenAIRE

    Jerabek, Jakub; Keil, Allessandra; Schoene, Jens; Chudoba, Rostislav; Hegger, Josef; Raupach, Michael

    2009-01-01

    The paper presents the study of spalling effect occurring under tensile loading in thin-walled TRC specimens. The experimentally observed failure patterns are first classified and the performed experiment design is explained and discussed. A parameter study of spalling effect with varied thickness of concrete cover and reinforcement configurations including both the textile fabrics and the yarns provided the basis for numerical analysis of the effect. The applied numerical model was designed ...

  13. Mining Financial Statement Fraud: An Analysis of Some Experimental Issues

    OpenAIRE

    West, J.; Bhattacharya, Maumita

    2015-01-01

    Financial statement fraud detection is an important problem with a number of design aspects to consider. Issues such as (i) problem representation, (ii) feature selection, and (iii) choice of performance metrics all influence the perceived performance of detection algorithms. Efficient implementation of financial fraud detection methods relies on a clear understanding of these issues. In this paper we present an analysis of the three key experimental issues associated with financial statement...

  14. Noise in transcription negative feedback loops: simulation and experimental analysis

    OpenAIRE

    Dublanche, Yann; Michalodimitrakis, Konstantinos; Kümmerer, Nico; Foglierini, Mathilde; Serrano, Luis

    2006-01-01

    Negative feedback loops have been invoked as a way to control and decrease transcriptional noise. Here, we have built three circuits to test the effect of negative feedback loops on transcriptional noise of an autoregulated gene encoding a transcription factor (TF) and a downstream gene (DG), regulated by this TF. Experimental analysis shows that self-repression decreases noise compared to expression from a non-regulated promoter. Interestingly enough, we find that noise minimization by negat...

  15. Uniaxial Fatigue of HDPE-100 Pipe. Experimental Analysis

    OpenAIRE

    Djebli, A.; A. Aid; M. Bendouba; Talha, A.; Benseddiq, N.; M. Benguediab; S. Zengah

    2014-01-01

    In this paper, an experimental analysis for determining the fatigue strength of PE-100, one of the most used High Density Polyethylene (HDPE) materials for pipes, under cyclic axial loadings is presented. HDPE is a thermoplastic material used for piping systems, such as natural gas distribution systems, sewer systems and cold water systems, which provides a good alternative to metals such as cast iron or carbon steel. One of the causes for failures of HDPE pipes is fatigue which is the result...

  16. Optimizing Nuclear Reaction Analysis (NRA) using Bayesian Experimental Design

    OpenAIRE

    von Toussaint, U.; Schwarz-Selinger, T.; Gori, S.

    2008-01-01

    Nuclear Reaction Analysis with ${}^{3}$He holds the promise to measure Deuterium depth profiles up to large depths. However, the extraction of the depth profile from the measured data is an ill-posed inversion problem. Here we demonstrate how Bayesian Experimental Design can be used to optimize the number of measurements as well as the measurement energies to maximize the information gain. Comparison of the inversion properties of the optimized design with standard settings reveals huge possi...

  17. Cognition, behavior, and the experimental analysis of behavior

    OpenAIRE

    Shimp, Charles P.

    1984-01-01

    A case history illustrates how one research program in the experimental analysis of behavior evolved somewhat differently from the modal research program represented in this journal. A chief issue that seems to be responsible for this difference is the role attributed to theory in behavioral research: Skinner's views on the nature and function of theory and on the nature of observation combine to produce a certain kind of picture of behavior. The classic conception of reinforcement contingenc...

  18. Multifractal Analysis of Aging and Complexity in Heartbeat Time Series

    Science.gov (United States)

    Muñoz D., Alejandro; Almanza V., Victor H.; del Río C., José L.

    2004-09-01

    Recently multifractal analysis has been used intensively in the analysis of physiological time series. In this work we apply the multifractal analysis to the study of heartbeat time series from healthy young subjects and other series obtained from old healthy subjects. We show that this multifractal formalism could be a useful tool to discriminate these two kinds of series. We used the algorithm proposed by Chhabra and Jensen that provides a highly accurate, practical and efficient method for the direct computation of the singularity spectrum. Aging causes loss of multifractality in the heartbeat time series, it means that heartbeat time series of elderly persons are less complex than the time series of young persons. This analysis reveals a new level of complexity characterized by the wide range of necessary exponents to characterize the dynamics of young people.

  19. Software Aging Analysis of Web Server Using Neural Networks

    Directory of Open Access Journals (Sweden)

    G.Sumathi

    2012-06-01

    Full Text Available Software aging is a phenomenon that refers to progressive performance degradation or transient failures or even crashes in long running software systems such as web servers. It mainly occurs due to the deterioration of operating system resource, fragmentation and numerical error accumulation. A primitive method to fight against software aging is software rejuvenation. Software rejuvenation is a proactive fault management technique aimed at cleaning up the system internal state to prevent the occurrence of more severe crash failures in the future. It involves occasionally stopping the running software, cleaning its internal state and restarting it. An optimized schedule for performing the software rejuvenation has to be derived in advance because a long running application could not be put down now and then as it may lead to waste of cost. This paper proposes a method to derive an accurate and optimized schedule for rejuvenation of a web server (Apache by using Radial Basis Function (RBF based Feed Forward Neural Network, a variant of Artificial Neural Networks (ANN. Aging indicators are obtained through experimental setup involving Apache web server and clients, which acts as input to the neural network model. This method is better than existing ones because usage of RBF leads to better accuracy and speed in convergence.

  20. Software Aging Analysis of Web Server Using Neural Networks

    Directory of Open Access Journals (Sweden)

    G.Sumathi

    2012-05-01

    Full Text Available Software aging is a phenomenon that refers to progressive performance degradation or transient failures or even crashes in long running software systems such as web servers. It mainly occurs due to the deterioration of operating system resource, fragmentation and numerical error accumulation. A primitive method to fight against software aging is software rejuvenation. Software rejuvenation is a proactive fault management technique aimed at cleaning up the system internal state to prevent the occurrence of more severe crash failures in the future. It involves occasionally stopping the running software, cleaning its internal state and restarting it. An optimized schedule for performing the software rejuvenation has to be derived in advance because a long running application could not be put down now and then as it may lead to waste of cost. This paper proposes a method to derive an accurate and optimized schedule for rejuvenation of a web server (Apache by using Radial Basis Function (RBF based Feed Forward Neural Network, a variant of Artificial Neural Networks (ANN. Aging indicators are obtained through experimental setup involving Apache web server and clients, which acts as input to the neural network model. This method is better than existing ones because usage of RBF leads to better accuracy and speed in convergence.

  1. Experimental and numerical analysis of a knee endoprosthesis numerical model

    Directory of Open Access Journals (Sweden)

    L. Zach

    2016-07-01

    Full Text Available The aim of this study is to create and verify a numerical model for a Medin Modular orthopedic knee-joint implant by investigating contact pressure, its distribution and contact surfaces. An experiment using Fuji Prescale pressure sensitive films and a finite element analysis (FEA using Abaqus software were carried out. The experimental data were evaluated using a special designed program and were compared with the results of the analysis. The designed evaluation program had been constructed on the basis of results obtained from a supplementary calibration experiment. The applicability of the numerical model for the real endoprosthesis behavior prediction was proven on the basis of their good correlation.

  2. Age-dependent differences in cytokine and antibody responses after experimental RSV infection in a bovine model

    DEFF Research Database (Denmark)

    Grell, S.N.; Riber, Ulla; Tjørnehøj, Kirsten;

    2005-01-01

    Respiratory syncytial virus (RSV) causes severe respiratory disease in both infants and calves. As in humans, bovine RSV (BRSV) infections are most severe in the first 6 months of life. In this study, experimental infection with BRSV was performed in calves aged 1-5, 9-16 or 32-37 weeks. Compared...

  3. Age estimation of bloodstains using smartphones and digital image analysis.

    Science.gov (United States)

    Thanakiatkrai, Phuvadol; Yaodam, Alisa; Kitpipit, Thitika

    2013-12-10

    Recent studies on bloodstains have focused on determining the time since deposition of bloodstains, which can provide useful temporal information to forensic investigations. This study is the first to use smartphone cameras in combination with a truly low-cost illumination system as a tool to estimate the age of bloodstains. Bloodstains were deposited on various substrates and photographed with a smartphone camera. Three smartphones (Samsung Galaxy S Plus, Apple iPhone 4, and Apple iPad 2) were compared. The environmental effects - temperature, humidity, light exposure, and anticoagulant - on the bloodstain age estimation process were explored. The color values from the digital images were extracted and correlated with time since deposition. Magenta had the highest correlation (R(2)=0.966) and was used in subsequent experiments. The Samsung Galaxy S Plus was the most suitable smartphone as its magenta decreased exponentially with increasing time and had highest repeatability (low variation within and between pictures). The quantifiable color change observed is consistent with well-established hemoglobin denaturation process. Using a statistical classification technique called Random Forests™, we could predict bloodstain age accurately up to 42 days with an error rate of 12%. Additionally, the age of forty blind stains were all correctly predicted, and 83% of mock casework samples were correctly classified. No within- and between-person variations were observed (p>0.05), while smartphone camera, temperature, humidity, and substrate color influenced the age determination process in different ways. Our technique provides a cheap, rapid, easy-to-use, and truly portable alternative to more complicated analysis using specialized equipment, e.g. spectroscopy and HPLC. No training is necessary with our method, and we envision a smartphone application that could take user inputs of environmental factors and provide an accurate estimate of bloodstain age. PMID:24314532

  4. Parameter sensitivity analysis of a simplified electrochemical and thermal model for Li-ion batteries aging

    Science.gov (United States)

    Edouard, C.; Petit, M.; Forgez, C.; Bernard, J.; Revel, R.

    2016-09-01

    In this work, a simplified electrochemical and thermal model that can predict both physicochemical and aging behavior of Li-ion batteries is studied. A sensitivity analysis of all its physical parameters is performed in order to find out their influence on the model output based on simulations under various conditions. The results gave hints on whether a parameter needs particular attention when measured or identified and on the conditions (e.g. temperature, discharge rate) under which it is the most sensitive. A specific simulation profile is designed for parameters involved in aging equations in order to determine their sensitivity. Finally, a step-wise method is followed to limit the influence of parameter values when identifying some of them, according to their relative sensitivity from the study. This sensitivity analysis and the subsequent step-wise identification method show very good results, such as a better fitting of the simulated cell voltage with experimental data.

  5. Morphological and functional features of the thymus of rats of different age periods in health and at experimental immunostimulation

    Directory of Open Access Journals (Sweden)

    Bobrysheva I.V.

    2013-12-01

    Full Text Available Background. Data on the structure of the thymus of white rats with experimental immunostimulation in age aspect presented only in a few publications. Objective. Morphofunctional features of the thymus of white male rats of three age periods: pubertal, reproductive and of expressed age-related changes, administered immunomodulator imunofan were studied. Methods. Features of the histological structure of the thymus were studied using an image analyzer based on microscope Olympus CX-41. Areas of subcapsular zone, the cortex and medulla, the total number of cells, lymphocytes and epitelioreticular cells conditional on a standard area (104 μm2 were determined; limphoepitelial index was calculated. Results. The thymus has specific morphological features of the structure in each age group of animals. The thymus of rats of pubertal period has the highest morphometric parameters which somewhat decreased in animals of reproductive period. Animals with expressed age-related changes have signs of age involution of the thymus (replacing of parenchyme of the organ by adipose and connective tissue, a sharp decline in morphometric parameters of morphofunctional zones. Conclusion. Application of imunofan causes unidirectional positive changes of morphometric parameters of the thymus in the rats of all age periods on 7-60 day of observation. In animals of the reproductive period and the period of expressed age-related changes injections of immunomodulator cause a decrease in the intensity of the involutive processes in the thymus.

  6. Desloratadine analysis: as a pharmaceutical preparation and after accelerating ageing

    Directory of Open Access Journals (Sweden)

    Bober Katarzyna

    2015-09-01

    Full Text Available Desloratadine is a biologically active compound that is not described in the Polish Pharmacopoeia IX, hence, its study is particular important. The aim of this work was to establish a procedure for desloratadine analysis by way of HPTLC in combination with densitometry, so as to be able to ascertain its presence and degree of presence within pharmaceutical preparations. In our work, a mixture of ethyl acetate, n-butanol, ammonia and methanol was used as the mobile phase. Moreover, HPTLC plates precoated with silica gel 60F254 were also employed. The proposed method was tested and subsequently validated. Spectrodensitometric analysis was then performed to determine the optimal wavelength for the quantitative determination (λ=276 nm, and following this, a quantitative analysis of desloratadine within certain pharmaceutical preparations was performed. Our research also took into consideration an analysis of the products of desloratadine decomposition that come about as a result of the accelerated aging of its solutions. The employed procedure for accelerating the aging of such desloratadine solutions consisted of heating these at 40℃ and then irradiating the solution surfaces with UV light. The changing color of these solutions after 2 hours of exposure served to indicate that degradation had occurred. Of note: as a result of irradiation with UV light, desloratadine content was seen to decrease with time, declining to almost zero after 30 hours. However, heating a solution of desloratadine alone did not induce a change in its content. Solutions of desloratadine that had previously undergone irradiation and heating were also analyzed to ascertain whether new substances were present. For this purpose, the GC-MS process was employed. As a result of this procedure, the spectrum of the solution after aging showed the presence of several new peaks that displayed retention several times larger and smaller than the normal desloratadine peak.

  7. PWR experimental benchmark analysis using WIMSD and PRIDE codes

    International Nuclear Information System (INIS)

    Highlights: • PWR experimental benchmark calculations were performed using WIMSD and PRIDE codes. • Various models for lattice cell homogenization were used. • Multiplication factors, power distribution and reaction rates were studied. • The effect of cross section libraries on these parameters was analyzed. • The results were compared with experimental and reported results. - Abstract: The PWR experimental benchmark problem defined by ANS was analyzed using WIMSD and PRIDE codes. Different modeling methodologies were used to calculate the infinite and effective multiplication factors. Relative pin power distributions were calculated for infinite lattice and critical core configurations, while reaction ratios were calculated for infinite lattice only. The discrete ordinate method (DSN) and collision probability method (PERSEUS) were used in each calculation. Different WIMSD cross-section libraries based on ENDF/B-VI.8, ENDF/B-VII.0, IAEA, JEF-2.2, JEFF-3.1 and JENDL-3.2 nuclear data files were also employed in the analyses. Comparison was made with experimental data and other reported results in order to find a suitable strategy for PWR analysis

  8. Cognition, behavior, and the experimental analysis of behavior.

    Science.gov (United States)

    Shimp, C P

    1984-11-01

    A case history illustrates how one research program in the experimental analysis of behavior evolved somewhat differently from the modal research program represented in this journal. A chief issue that seems to be responsible for this difference is the role attributed to theory in behavioral research: Skinner's views on the nature and function of theory and on the nature of observation combine to produce a certain kind of picture of behavior. The classic conception of reinforcement contingencies is tied to this particular picture. But this picture may be incompatible with, and certainly is different from, other possible pictures. Reinforcement contingencies that place greater emphasis on the local temporal patterning of behavior seem tied to some of these alternative pictures of what behavior is. These other pictures encourage a wide range of theoretical approaches, including cognitive ones, various kinds of mathematical analyses, and computer-simulation methods to characterize entire behavior streams. In the future, perhaps the experimental analysis of behavior will accept a somewhat different range of views on the nature and function of theory, a correspondingly different set of experimental methods, and alternative ways of talking about behavior. PMID:16812399

  9. Experimental and Fe Analysis of Eccentric Loaded Welded Joint Structure

    Directory of Open Access Journals (Sweden)

    Harish N. Sayankar

    2014-08-01

    Full Text Available Arc welded structures are widely used in automobiles, constructions & power plants. As the main cause of weldment failure is design defect & overload, hence it is necessary to analyze the maximum stresses in the weldment. In this project experimentation is carried out on symmetrical and unsymmetrical eccentric loaded welded joint to determine the breaking stress in the weldment. The FE analysis & analytical estimation of breaking stress is also carried out to verify the experimental results. The stress distribution along weld size & throat thickness is evaluated and also compared with reported findings under same loading condition. Further eccentric loaded welded joint is analyzed under eccentric load by varying the gap between parent plates.

  10. Experimental investigation of thermal neutron analysis based landmine detection technology

    International Nuclear Information System (INIS)

    Background: Recently, the prompt gamma-rays neutron activation analysis method is wildly used in coal analysis and explosive detection, however there were less application about landmine detection using neutron method especially in the domestic research. Purpose: In order to verify the feasibility of Thermal Neutron Analysis (TNA) method used in landmine detection, and explore the characteristic of this technology. Methods: An experimental system of TNA landmine detection was built based on LaBr3 (Ce) fast scintillator detector and 252Cf isotope neutron source. The system is comprised of the thermal neutron transition system, the shield system, and the detector system. Results: On the basis of the TNA, the wide energy area calibration method especially to the high energy area was investigated, and the least detection time for a typical mine was defined. In this study, the 72-type anti-tank mine, the 500 g TNT sample and several interferential objects are tested in loess, red soil, magnetic soil and sand respectively. Conclusions: The experimental results indicate that TNA is a reliable demining method, and it can be used to confirm the existence of Anti-Tank Mines (ATM) and large Anti-Personnel Mines (APM) in complicated condition. (authors)

  11. Experimental and Numerical Analysis of Notched Composites Under Tension Loading

    Science.gov (United States)

    Aidi, Bilel; Case, Scott W.

    2015-12-01

    Experimental quasi-static tests were performed on center notched carbon fiber reinforced polymer (CFRP) composites having different stacking sequences made of G40-600/5245C prepreg. The three-dimensional Digital Image Correlation (DIC) technique was used during quasi-static tests conducted on quasi-isotropic notched samples to obtain the distribution of strains as a function of applied stress. A finite element model was built within Abaqus to predict the notched strength and the strain profiles for comparison with measured results. A user-material subroutine using the multi-continuum theory (MCT) as a failure initiation criterion and an energy-based damage evolution law as implemented by Autodesk Simulation Composite Analysis (ASCA) was used to conduct a quantitative comparison of strain components predicted by the analysis and obtained in the experiments. Good agreement between experimental data and numerical analyses results are observed. Modal analysis was carried out to investigate the effect of static damage on the dominant frequencies of the notched structure using the resulted degraded material elements. The first in-plane mode was found to be a good candidate for tracking the level of damage.

  12. An experimental test for age-related improvements in reproductive performance in a frog that cares for its young

    Science.gov (United States)

    Dugas, Matthew B.; Moore, Michael P.; Wamelink, Caitlin N.; Richards-Zawacki, Corinne L.; Martin, Ryan A.

    2015-10-01

    Reproductive performance often increases with age in long-lived iteroparous organisms, a pattern that can result from within-individual increases in effort and/or competence. In free-living populations, it is typically difficult to distinguish these mechanisms or to isolate particular features of reproduction-influencing outcomes. In captive Oophaga pumilio, a frog in which mothers provide extended offspring provisioning via trophic eggs, we experimentally manipulated the age at which females started breeding and then monitored them across repeated reproductive events. This experiment allowed us to decouple age and experience and isolate maternal care as the proximate source of any differences in performance. Younger first-time mothers produced larger broods than older first-time mothers, but did not rear more offspring to independence. Across repeated reproductive events, maternal age was unassociated with any metric of performance. At later reproductive events, however, mothers produced fewer metamorphs, and a lower proportion of individuals in their broods reached independence. These patterns suggest that performance does not improve with age or breeding experience in this frog, and that eventual declines in performance are driven by reproductive activity, not age per se. Broadly, age-specific patterns of reproductive performance may depend on the proximate mechanism by which parents influence offspring fitness and how sensitive these are to effort and competence.

  13. An experimental investigation of age discrimination in hiring in the English labour market

    OpenAIRE

    Riach, P.; Rich, Judy

    2007-01-01

    Carefully-matched pairs of written job applications were made to test for age discrimination in hiring. A twenty-one year-old and a thirty-nine year-old woman applied for jobs where a “new graduate” was sought; men aged twenty-seven and forty-seven, inquired about employment as waiters; women aged twenty-seven and forty-seven, inquired about employment in retail sales. The rate of net discrimination against the older graduate, and against the older waiters in their London inquiries, correspon...

  14. Experimental bifurcation analysis of an impact oscillator – Determining stability

    DEFF Research Database (Denmark)

    Bureau, Emil; Schilder, Frank; Elmegård, Michael;

    2014-01-01

    We propose and investigate three different methods for assessing stability of dynamical equilibrium states during experimental bifurcation analysis, using a control-based continuation method. The idea is to modify or turn off the control at an equilibrium state and study the resulting behavior......-time Lyapunov exponents. As a special case we study an isolated branch in the bifurcation diagram brought into existence by a 1:3 subharmonic resonance. On this isola it is only possible to determine stability using one of the three methods, which is due to the fact that only this method guarantees...

  15. Analysis of variance tables based on experimental structure.

    Science.gov (United States)

    Brien, C J

    1983-03-01

    A stepwise procedure for obtaining the experimental structure for a particular experiment is presented together with rules for deriving the analysis-of-variance table from that structure. The procedure involves the division of the factors into groups and is essentially a generalization of the method of Nelder (1965, Proceedings of the Royal Society, Series A 283, 147-162; 1965, Proceedings of the Royal Society, Series A 283, 163-178), to what are termed 'multi-tiered' experiments. The proposed method is illustrated for a wine-tasting experiment. PMID:6871362

  16. Experimental and CFD analysis of nozzle position of subsonic ejector

    Institute of Scientific and Technical Information of China (English)

    Xilai ZHANG; Shiping JIN; Suyi HUANG; Guoqing TIAN

    2009-01-01

    The influence of nozzle position on the performance of an ejector was analyzed qualitatively with free jet flow model. Experimental investigations and computational fluid dynamics (CFD) analysis of the nozzle position of the subsonic ejector were also conducted. The results show that there is an optimum nozzle position for the ejector. The ejecting coefficient reaches its maximum when the nozzle is positioned at the optimum and decreases when deviating. Moreover, the nozzle position of an ejector is not a fixed value, but is influenced greatly by the flow parameters. Considering the complexity of the ejector, CFD is reckoned as a useful tool in the design of ejectors.

  17. Do Different Neurons Age Differently? Direct Genome-Wide Analysis of Aging in Single Identified Cholinergic Neurons

    OpenAIRE

    Moroz, Leonid L.; Kohn, Andrea B.

    2010-01-01

    Aplysia californica is a powerful experimental system to study the entire scope of genomic and epigenomic regulation at the resolution of single functionally characterized neurons and is an emerging model in the neurobiology of aging. First, we have identified and cloned a number of evolutionarily conserved genes that are age-related, including components of apoptosis and chromatin remodeling. Second, we performed gene expression profiling of different identified cholinergic neurons between y...

  18. Determination of gunshot residues with image analysis: an experimental study.

    Science.gov (United States)

    Tuğcu, Harun; Yorulmaz, Coşkun; Bayraktaroğlu, Görgün; Uner, Hüseyin Bülent; Karslioğlu, Yildirim; Koç, Sermet; Ulukan, Mustafa Ozer; Celasun, Bülent

    2005-09-01

    In firearm injuries, assessment of the firing range and determination of entrance and exit wounds are important. For this reason, evaluation of the amount and distribution of gunshot residues (GSRs) is necessary. Several methods and techniques for GSR analysis have been developed. Although these methods are relatively sensitive and specific, they may require expensive dedicated equipment. Therefore, a simple, easily applicable, more convenient method is needed. A total of 40 experimental shots were made to calf skin from distances of 0, 2.5, 5, 10, 20, 30, 45, and 60 cm. Eighty samples were taken from the right and left sides of the wounds, and Alizarin Red S dye staining was performed. The amounts of GSR particles were measured with image analysis. GSRs were detected in all shots. The mean size of the distribution area of barium and lead elements around the wound had a significant negative correlation with increasing shooting distance (r = -0.97, p distance increased, the amount of GSR decreased, and this decrease rate was nonlinear. Variance analysis suggested significant differences between data groups depending on range (p < 0.001). The image analysis method may solve some of the standardization problems for evaluation of GSRs. GSR detection with the image analysis method does not require experienced personnel and may be a suitable method for scientific studies and for routine purposes. PMID:16261988

  19. Statistics in experimental design, preprocessing, and analysis of proteomics data.

    Science.gov (United States)

    Jung, Klaus

    2011-01-01

    High-throughput experiments in proteomics, such as 2-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS), yield usually high-dimensional data sets of expression values for hundreds or thousands of proteins which are, however, observed on only a relatively small number of biological samples. Statistical methods for the planning and analysis of experiments are important to avoid false conclusions and to receive tenable results. In this chapter, the most frequent experimental designs for proteomics experiments are illustrated. In particular, focus is put on studies for the detection of differentially regulated proteins. Furthermore, issues of sample size planning, statistical analysis of expression levels as well as methods for data preprocessing are covered.

  20. Experimental and Analytical Analysis of Perforated Plate Aerodynamics

    Institute of Scientific and Technical Information of China (English)

    Jürgen Zierep; Rainer Bohning; Piotr Doerffer

    2003-01-01

    Perforated walls and transpiration flow play an important role in aerodynamics due to an increasing interest in application of flow control by means of blowing and/or suction. An experimental study was carried out which has led to the determination of a transpiration flow characteristics in the form of a simple formula that is very useful in modelling such flows. In connection to this relation a method of "aerodynamic porosity" determination has been proposed which is much more reliable than geometric description of the porosity. A theoretical analysis of the flow through a perforation hole was also carried out. The flow was considered as compressible and viscous. The gasdynamic analysis led us to a very similar result to the relation obtained from the experiment. The adequacy of the theoretical result is discussed in respect to the experiment.

  1. Single-neuron transcriptome and methylome sequencing for epigenomic analysis of aging.

    Science.gov (United States)

    Moroz, Leonid L; Kohn, Andrea B

    2013-01-01

    Enormous heterogeneity in transcription and signaling is the feature that slows down progress in our understanding of the mechanisms of normal aging and age-related diseases. This is critical for neurobiology of aging where the enormous diversity of neuronal populations presents a significant challenge in experimental design. Here, we introduce Aplysia as a model for genomic analysis of aging at the single-cell level and provide protocols for integrated transcriptome and methylome profiling of individually identified neurons during the aging process. These single-cell RNA-seq and DNA methylation assays (methyl-capture/methyl enrichment) are compatible with all major next generation sequencing platforms (we used Roche/454 and SOLiD/Life Technologies as illustrative examples) and can be used to integrate an epigenetic signature with transcriptional output. The described sequencing library construction protocol provides both quantitative and directional information from transcriptional profiling of individual cells. Our results also confirm that different copies of DNA in polyploid Aplysia neurons behave similarly with respect to their DNA methylation.

  2. Analysis of experimental biosensor/FIA lactose measurements

    Directory of Open Access Journals (Sweden)

    L.S. Ferreira

    2003-03-01

    Full Text Available Whey is an abundant effluent in the production of cheese and casein. The biotechnological utilization of this economically important and nutritive source is limited mainly because of the presence of high percentages of lactose. This disaccharide has poor solubility, which can cause crystallization and insufficient sweetness in dairy food; additionally, part of the adult population suffers from associated lactose intolerance diseases. There are several methods to determine lactose such as spectrophotometry, polarimetry, infrared spectroscopy, titrimetry and chromatography. However these methods are tedious and time-consuming due to long sample preparation. These disadvantages stimulated the development of an enzymatic lactose biosensor. It employs two immobilized enzymes, beta-galactosidase and glucose oxidase and the quantitative analysis of lactose is based on determination of oxygen consumption in the enzymatic reaction. The influence of temperature on the biosensor signal was experimentally studied. It was observed that a nonlinear relationship exists between the electric response of the biosensor - provided by CAFCA (Computer Assisted Flow Control & Analysis - ANASYSCON, Hannover - and lactose concentration. In this work, attempts were made to correlate these variables using a simple nonlinear model and multilayered neural networks, with the latter providing the best modeling of the experimental data.

  3. Age determination and development of experimental methods for quaternary fault and formation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kwang Sik; Choi, M. S.; Kim, J. M. [Korea Basic Science Institute, Daejeon (Korea, Republic of)] (and others)

    2004-02-15

    Late cretaceous to early tertiary movement ages were constrained by Rb-Sr and K-Ar dating of fault rocks near the Uljin Nuclear Power Plants. These ages are well reproducible and consistent with geologic context. Tectonic evolution of the northeastern Yeongnam massif, the site of the Uljin Nuclear Power Plants, was investigated on the basis of Rb-Sr, Sm-Nd and Pb isotopic systematics and geochemistry of precambrian basement rocks including the Hosanri Formation, Buncheon granite gneiss, biotite granite gneiss, and Hongjesa granite. The optical ages from the Suryum fault outcrop represent the younger limit of sedimentation timing because they are simply based upon the present-day water content. The lower, Qt{sub 2} terrace at about 18m elevation is correlated with Marine Isotopic Stage (MIS) 5a, although its apparent optical age was consistently reported from 71 to 48 ka. Correlation of shoreline elevations indicates the correspondence of the Qt{sub 3a} terrace to MIS 5e, which is supported by stratigraphically concordant optical ages for aeolian sand dunes at the north of the Suryum site. This time scale yields an uplift rate of 0.266 m/ka, requiring the revision of conventional view that the Korean peninsula is tectonically very stable.

  4. Age determination and development of experimental methods for quaternary fault and formation

    International Nuclear Information System (INIS)

    Late cretaceous to early tertiary movement ages were constrained by Rb-Sr and K-Ar dating of fault rocks near the Uljin Nuclear Power Plants. These ages are well reproducible and consistent with geologic context. Tectonic evolution of the northeastern Yeongnam massif, the site of the Uljin Nuclear Power Plants, was investigated on the basis of Rb-Sr, Sm-Nd and Pb isotopic systematics and geochemistry of precambrian basement rocks including the Hosanri Formation, Buncheon granite gneiss, biotite granite gneiss, and Hongjesa granite. The optical ages from the Suryum fault outcrop represent the younger limit of sedimentation timing because they are simply based upon the present-day water content. The lower, Qt2 terrace at about 18m elevation is correlated with Marine Isotopic Stage (MIS) 5a, although its apparent optical age was consistently reported from 71 to 48 ka. Correlation of shoreline elevations indicates the correspondence of the Qt3a terrace to MIS 5e, which is supported by stratigraphically concordant optical ages for aeolian sand dunes at the north of the Suryum site. This time scale yields an uplift rate of 0.266 m/ka, requiring the revision of conventional view that the Korean peninsula is tectonically very stable

  5. Aging effect on successful reactive-recovery from unexpected slips: a 3D lower extremity joint moment analysis

    OpenAIRE

    Liu, Jian

    2004-01-01

    The objective of the proposed study was to perform three-dimensional (3D) inverse dynamics analysis to determine lower extremity (ankle, knee and hip) joint moments on previously collected slip perturbation experimental data. In addition, the aging effect on the joint moment generation in both normal walking and reactive-recovery conditions was examined. Dataset collected during previous slip and fall experiments, which were conducted in a typical gait analysis setting, were analyzed in cu...

  6. Genetic analysis of intracapillary glomerular lipoprotein deposits in aging mice.

    Directory of Open Access Journals (Sweden)

    Gerda A Noordmans

    Full Text Available BACKGROUND: Renal aging is characterized by functional and structural changes like decreased glomerular filtration rate, and glomerular, tubular and interstitial damage. To gain insight in pathways involved in renal aging, we studied aged mouse strains and used genetic analysis to identify genes associated with aging phenotypes. METHODS: Upon morphological screening in kidneys from 20-month-old mice from 26 inbred strains we noted intracapillary PAS-positive deposits. The severity of these deposits was quantified by scoring of a total of 50 glomeruli per section (grade 0-4. Electron microscopy and immunohistochemical staining for apoE, apoB, apoA-IV and perilipin-2 was performed to further characterize the lesions. To identify loci associated with these PAS-positive intracapillary glomerular deposits, we performed haplotype association mapping. RESULTS: Six out of 26 mouse strains showed glomerular PAS-positive deposits. The severity of these deposits varied: NOD(0.97, NZW(0.41, NON(0.30, B10(0.21, C3 H(0.9 and C57BR(0.7. The intracapillary deposits were strongly positive for apoE and weakly positive for apoB and apoA-IV. Haplotype association mapping showed a strong association with a 30-Kb haplotype block on Chr 1 within the Esrrg gene. We investigated 1 Mb on each site of this region, which includes the genes Spata17, Gpatch2, Esrrg, Ush2a and Kctd3. CONCLUSIONS: By analyzing 26 aged mouse strains we found that some strains developed an intracapillary PAS and apoE-positive lesion and identified a small haplotype block on Chr 1 within the Esrrg gene to be associated with these lipoprotein deposits. The region spanning this haplotype block contains the genes Spata17, Gpatch2, Esrrg, Ush2a and Kctd3, which are all highly expressed in the kidney. Esrrg might be involved in the evolvement of these glomerular deposits by influencing lipid metabolism and possibly immune reponses.

  7. Identifying Effective Spelling Interventions Using a Brief Experimental Analysis and Extended Analysis

    Science.gov (United States)

    McCurdy, Merilee; Clure, Lynne F.; Bleck, Amanda A.; Schmitz, Stephanie L.

    2016-01-01

    Spelling is an important skill that is crucial to effective written communication. In this study, brief experimental analysis procedures were used to examine spelling instruction strategies (e.g., whole word correction; word study strategy; positive practice; and cover, copy, and compare) for four students. In addition, an extended analysis was…

  8. Experimental Investigation on the Internal Resistance of Lithium Iron Phosphate Battery Cells during Calendar Ageing

    DEFF Research Database (Denmark)

    Stroe, Daniel Ioan; Swierczynski, Maciej Jozef; Stan, Ana-Irina;

    2013-01-01

    Lithium-ion batteries are increasingly considered for a wide area of applications because of their superior characteristics in comparisons to other energy storage technologies. However, at present, Lithium-ion batteries are expensive storage devices and consequently their ageing behavior must be ...

  9. A bout analysis reveals age-related methylmercury neurotoxicity and nimodipine neuroprotection.

    Science.gov (United States)

    Shen, Andrew Nathanael; Cummings, Craig; Pope, Derek; Hoffman, Daniel; Newland, M Christopher

    2016-09-15

    Age-related deficits in motor and cognitive functioning may be driven by perturbations in calcium (Ca(2+)) homeostasis in nerve terminals, mechanisms that are also thought to mediate the neurotoxicity of methylmercury (MeHg). Calcium-channel blockers (CCBs) protect against MeHg toxicity in adult mice, but little is known about their efficacy in other age groups. Two age groups of BALB/c mice were exposed to 0 or 1.2mg/kg/day MeHg and 0 or 20mg/kg/day of the CCB nimodipine for approximately 8.5 months. Adults began exposure on postnatal day (PND) 72 and the retired breeders on PND 296. High-rate operant behavior was maintained under a percentile schedule, which helped to decouple response rate from reinforcer rate. Responding was analyzed using a log-survivor bout analysis approach that partitioned behavior into high-rate bouts separated by pauses. MeHg-induced mortality did not depend on age but nimodipine neuroprotection was age-dependent, with poorer protection occurring in older mice. Within-bout response rate (a marker of sensorimotor function) was more sensitive to MeHg toxicity than bout-initiation rate (a marker of motivation). Within-bout rate declined almost 2 months prior to overt signs of toxicity for the MeHg-only retired breeders but not adults, suggesting greater delay to toxicity in younger animals. Motor-based decrements also appeared in relatively healthy adult MeHg+NIM animals. Aging appeared to alter the processes underlying Ca(2+) homeostasis thereby diminishing protection by nimodipine, even in mice that have not reached senescence. The study of MeHg exposure presents an experimental model by which to study potential mechanisms of aging. PMID:27196441

  10. Uranium age determination: Separation and analysis of 230Th and 231Pa

    International Nuclear Information System (INIS)

    In this work we focused on the age determination of uranium materials of different uranium enrichment. The radioactive decay of the uranium isotopes provides a chronometer that is inherent to the material, in particular the mother/daughter pairs 234U/230Th and 235U/231Pa can be advantageously used. Due to the relatively long half-lives of 234U (2.46 · 105 years) and 235U (7.04 · 108 years) only minute amounts of daughter nuclides are growing in, therefore both separation of Th and Pa from uranium must be of high chemical recovery and must afford large decontamination factors. Analytical methods for the age determination of uranium samples using the parent/daughter relations 234U/230Th and 235U/231Pa is demonstrated. Thorium is separated from bulk uranium using extraction chromatography and subsequently quantified using square-spectrometry, thermal ionisation mass spectrometry (TIMS) and inductively coupled mass spectrometry (ICP-MS). Protactinium is separated by highly selective sorption of protactinium to silica gel followed by square-spectrometric quantification. The methods were tested and validated using uranium reference materials of different uranium enrichment and of known ages. The experimental results obtained with both methods were found to agree with the assumed ages of the reference materials within the combined uncertainty of the measurement. The analysis exploiting the parent/daughter pair 235U/231Pa exhibits a slightly larger combined uncertainty and bias than the thorium method but is found valuable in validating the experimental results by means of a second, independent analysis

  11. Aging does not enhance experimental cigarette smoke-induced COPD in the mouse.

    Directory of Open Access Journals (Sweden)

    Steven Zhou

    Full Text Available It has been proposed that the development of COPD is driven by premature aging/premature senescence of lung parenchyma cells. There are data suggesting that old mice develop a greater inflammatory and lower anti-oxidant response after cigarette smoke compared to young mice, but whether these differences actually translate into greater levels of disease is unknown. We exposed C57Bl/6 female mice to daily cigarette smoke for 6 months starting at age 3 months (Ayoung@ or age 12 months (Aold@, with air-exposed controls. There were no differences in measures of airspace size between the two control groups and cigarette smoke induced exactly the same amount of emphysema in young and old. The severity of smoke-induced small airway remodeling using various measures was identical in both groups. Smoke increased numbers of tissue macrophages and neutrophils and levels of 8-hydroxyguanosine, a marker of oxidant damage, but there were no differences between young and old. Gene expression studies using laser capture microdissected airways and parenchyma overall showed a trend to lower levels in older animals and a somewhat lesser response to cigarette smoke in both airways and parenchyma but the differences were usually not marked. Telomere length was greatest in young control mice and was decreased by both smoking and age. The senescence marker p21(Waf1 was equally upregulated by smoke in young and old, but p16(INK4a, another senescence marker, was not upregulated at all. We conclude, in this model, animal age does not affect the development of emphysema and small airway remodeling.

  12. Experimental study on ultrasonic pulse velocity evaluation of the microstructure of cementitious material at early age

    NARCIS (Netherlands)

    Guang Ye; Van Breugel, K.; Fraaij, A.L.A.

    2001-01-01

    This paper describes an ultrasonic experimental set-up to monitor the development of the microstructure of fresh concrete at different temperatures (isothermal curing at 10, 20, 30 and 50 °C) and water/cement ratios (0.40, 0.45 and 0.55). The Ultrasonic Pulse Velocity (UPV) is used as an indication

  13. THE STRUCTURE ANALYSIS OF POPULATION BY AGE GROUPS IN THE RURAL AREAS OF BUCOVINA

    Directory of Open Access Journals (Sweden)

    NICOLETA ILEANA MORAR (BUMBU

    2015-12-01

    Full Text Available The structure analysis of population by age groups in the rural area of Bucovina desires to create a recent image of the rural population by age groups in the region of Bucovina , provided that after the year 2000 have occurred socio – economic changes with repercussions on the demographic component. The structure analysis by age group will be based on the share of population indicators on the major age groups, the share of population by age and quinquennial gender illustrated by age pyramid, the index of demographic aging and age-dependency ratio. This study is definitely needed in forecasting future regional development objectives and measures.

  14. Age-Related Macular Degeneration: A Scientometric Analysis

    Science.gov (United States)

    Ramin, Shahrokh; Soheilian, Masoud; Habibi, Gholamreza; Ghazavi, Roghayeh; Gharebaghi, Reza; Heidary, Fatemeh

    2015-01-01

    Age-related macular degeneration (ARMD) is a major cause of central blindness among working aged adults across the world. Systematic research planning on any subject, including ARMD is in need of solid data regarding previous efforts in this field and to identify the gaps in the research. This study aimed to elucidate the most important trends, directions, and gap in this subject. The data extracted from the Institute for Scientific Information were used to perform a bibliometric analysis of the scientific productions (1993–2013) about ARMD. Specific parameters related to ARMD were analyzed to obtain a view of the topic’s structure, history, and document relationships. Additionally, the trends and authors in the most influential publications were analyzed. The number of articles in this field was found constantly increasing. Most highly cited articles addressed genetic epidemiology and clinical research topics in this field. During the past 3 years, there has been a trend toward biomarker research. Through performing the first scientometric survey on ARMD research, we analyzed the characteristics of papers and the trends in scientific production. We also identified some of the critical gaps in the current research efforts that would help in large-scale research strategic planning. PMID:26060829

  15. Age-Related Macular Degeneration: A Scientometric Analysis.

    Science.gov (United States)

    Ramin, Shahrokh; Soheilian, Masoud; Habibi, Gholamreza; Ghazavi, Roghayeh; Gharebaghi, Reza; Heidary, Fatemeh

    2015-01-01

    Age-related macular degeneration (ARMD) is a major cause of central blindness among working aged adults across the world. Systematic research planning on any subject, including ARMD is in need of solid data regarding previous efforts in this field and to identify the gaps in the research. This study aimed to elucidate the most important trends, directions, and gap in this subject. The data extracted from the Institute for Scientific Information were used to perform a bibliometric analysis of the scientific productions (1993-2013) about ARMD. Specific parameters related to ARMD were analyzed to obtain a view of the topic's structure, history, and document relationships. Additionally, the trends and authors in the most influential publications were analyzed. The number of articles in this field was found constantly increasing. Most highly cited articles addressed genetic epidemiology and clinical research topics in this field. During the past 3 years, there has been a trend toward biomarker research. Through performing the first scientometric survey on ARMD research, we analyzed the characteristics of papers and the trends in scientific production. We also identified some of the critical gaps in the current research efforts that would help in large-scale research strategic planning. PMID:26060829

  16. Comparative analysis of the rate of aging young people of student age

    Directory of Open Access Journals (Sweden)

    Prikhodko S.I.

    2012-07-01

    Full Text Available The problem of accelerated rates of aging of young people by the example of students. The data calculating biological age students on how Voitenko. Displaying discrepancy between passport and biological age boys and girls. 27 youths and 20 girls that study on 2 courses took part in research, on the state a health behave to the basic medical group. It is proved that the young men in the period of study have higher rates of aging. Found that young biological age than passport for 26 years, while the girls - at 11. It is used data of other authors to compare the biological age of students in different regions of Ukraine. It is recommended to give students information about their biological age and teach them to control this index during life.

  17. EXPERIMENTAL INVESTIGATION & NUMERICAL ANALYSIS OF COMPOSITE LEAF SPRING

    Directory of Open Access Journals (Sweden)

    K. K. JADHAO,

    2011-06-01

    Full Text Available The Automobile Industry has shown keen interest for replacement of steel leaf spring with that of glass fiber composite leaf spring, since the composite material has high strength to weight ratio, good corrosion resistance and tailor-able properties. The objective of present study was to replace material for leaf spring. In present study the material selected was glass fiber reinforced plastic (GFRP and the polyester resin (NETPOL 1011 can be used which was more economical this will reduce total cost of composite leaf spring. A spring with constant width and thickness was fabricated by hand lay-up technique which was very simple and economical. The experiments were conducted on UTM and numerical analysis was done via (FEA using ANSYS software. Stresses and deflection results were verified for analytical and experimental results. Result shows that, the composite spring has stresses much lower than steel leaf spring and weight of composite spring was nearly reduced up to 85%.

  18. The Experimental Analysis Of An Innovative Yielding Metallic Damper

    Directory of Open Access Journals (Sweden)

    Venghiac Vasile-Mircea

    2015-05-01

    Full Text Available One of the most destructive natural phenomena is the earthquake. These events destroy lives, goods and disrupt human activities. For this reason the anti-seismic protection of buildings is a very important and of interest subject in Civil Engineering. In the case of structures with a low seismic energy dissipation capacity (for example steel frame structures with Slimdek composite floors, this problem becomes more complicated due to the requirement of dampers. In this paper an experimental study is presented regarding an innovative yielding metallic energy dissipation device, proposed by the author. An experiment is carried out on a shake table. By studying the results from the experiments and from the previous carried out numerical analysis we can conclude that this device provides a high anti-seismic protection for this type of structures.

  19. Creep and Shrinkage of High Strength Concretes: an Experimental Analysis

    Directory of Open Access Journals (Sweden)

    Berenice Martins Toralles carbonari

    2002-01-01

    Full Text Available The creep and shrinkage behaviour of high strength silica fume concretes is significantly different from that of conventional concretes. In order to represent the proper time-dependent response of the material in structural analysis and design, these aspects should be adequately quantified. This paper discusses an experimental setup that is able to determine the creep and shrinkage of concrete from the time of placing. It also compares different gages that can be used for measuring the strains. The method is applied to five different concretes in the laboratory under controlled environmental conditions. The phenomena that are quantified can be classified as basic shrinkage, drying shrinkage, basic creep and drying creep. The relative importance of these mechanisms in high strength concrete will also be presented.

  20. An Experimental Research into the Anti-aging Effects of Radix Arctii Lappae

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Purpose: To delve into the anti-aging effects and mechanism of Niubanggen (牛蒡根Radix Arctii Lappae). Method: The activity of SOD and the content of MDA and lipofuscin in the tissues of the liver,brain and blood serum of the lab rats were observed 30 days after they had been fed with the Niubanggen decoction. Result: The activity of SOD in the liver tissue and blood serum of the decoction-fed lab rats was improved dramatically (P<0.05 or P<0.01), the content of MDA in the brain tissue and blood serum lowered obviously (P<0.05 or P<0.01), and the content of lipofuscin dropped distinctly (P<0.01). Conclusion: The mechanism of the anti-aging effects of the Niubanggen is mainly obtained by raising the activity of SOD and reducing the contents of MDA and lipofuscin.

  1. Random Probability Analysis of 48Ca +239Pu Experimental Data

    Science.gov (United States)

    Strauss, S. Y.; Henderson, R. A.; Stoyer, M. A.; Abdullin, A. F. Sh.; Brewer, N. T.; Dmitriev, S. N.; Grzywacz, R. K.; Hamilton, J. H.; Itkis, M. G.; Miernik, K.; Oganessian, Yu. Ts.; Polyakov, A. N.; Roberto, J. B.; Rykaczewski, K. P.; Sabelnikov, A. V.; Sagaidak, R. N.; Shirokovsky, I. V.; Shumeyko, M. V.; Subbotin, V. G.; Sukhov, A. M.; Tsyganov, Yu. S.; Utyonkov, V. K.; Voinov, A. A.; Vostokin, G. K.

    2014-09-01

    Element 114 (Fl), was discovered at the Flerov Laboratory of Nuclear Reactions (FLNR) using the 48Ca +244Pu reaction and the Dubna Gas-Filled Recoil Separator (DGFRS). The structural properties of the super heavy elements are still largely unknown. The extent of the region of enhanced stability near Z = 114 and N = 184 is not completely known. To examine these properties, a new experimental data set has been taken using the 48Ca +239Pu reaction at the DGFRS, in an effort to look for lighter isotopes of Fl. Progress on the production of lighter isotopes of Fl, cross-section measurements, and any nuclear decay properties will be discussed. Comparisons with reactions using heavier 242,244Pu targets and Monte Carlo random probability analysis will be highlighted. Element 114 (Fl), was discovered at the Flerov Laboratory of Nuclear Reactions (FLNR) using the 48Ca +244Pu reaction and the Dubna Gas-Filled Recoil Separator (DGFRS). The structural properties of the super heavy elements are still largely unknown. The extent of the region of enhanced stability near Z = 114 and N = 184 is not completely known. To examine these properties, a new experimental data set has been taken using the 48Ca +239Pu reaction at the DGFRS, in an effort to look for lighter isotopes of Fl. Progress on the production of lighter isotopes of Fl, cross-section measurements, and any nuclear decay properties will be discussed. Comparisons with reactions using heavier 242,244Pu targets and Monte Carlo random probability analysis will be highlighted. This work was performed under Contract DE-AC52-07NA27344 and Grant DE-NA0002135.

  2. Modeling and experimental vibration analysis of nanomechanical cantilever active probes

    International Nuclear Information System (INIS)

    Nanomechanical cantilever (NMC) active probes have recently received increased attention in a variety of nanoscale sensing and measurement applications. Current modeling practices call for a uniform cantilever beam without considering the intentional jump discontinuities associated with the piezoelectric layer attachment and the NMC cross-sectional step. This paper presents a comprehensive modeling framework for modal characterization and dynamic response analysis of NMC active probes with geometrical discontinuities. The entire length of the NMC is divided into three segments of uniform beams followed by applying appropriate continuity conditions. The characteristics matrix equation is then used to solve for system natural frequencies and mode shapes. Using an equivalent electromechanical moment of a piezoelectric layer, forced motion analysis of the system is carried out. An experimental setup consisting of a commercial NMC active probe from Veeco and a state-of-the-art microsystem analyzer, the MSA-400 from Polytec, is developed to verify the theoretical developments proposed here. Using a parameter estimation technique based on minimizing the modeling error, optimal values of system parameters are identified. Mode shapes and the modal frequency response of the system for the first three modes determined from the proposed model are compared with those obtained from the experiment and commonly used theory for uniform beams. Results indicate that the uniform beam model fails to accurately predict the actual system response, especially in multiple-mode operation, while the proposed discontinuous beam model demonstrates good agreement with the experimental data. Such detailed and accurate modeling framework can lead to significant enhancement in the sensitivity of piezoelectric-based NMC sensors for use in variety of sensing and imaging applications

  3. The decay of 'mesotrons' (1939-1943), experimental particle physics in the age of innocence

    Science.gov (United States)

    Rossi, B.

    1983-01-01

    An account is given of the experimental work carried out by the author and his associates during the years 1939 through 1943, which produced the first unambiguous evidence of the spontaneous decay of 'mesotrons', showed that this decay occurred according to an exponential law, as expected, and measured the mean life with a 3 percent accuracy. A byproduct of this work was a verification of the relativistic equation for the dilation of time intervals. Previously announced in STAR as N81-76151

  4. [Cholagogic effect of trimethylglycine in normal animals of different ages and in experimental atherosclerosis].

    Science.gov (United States)

    Zapadniuk, V I; Panteleĭmonova, T N

    1987-07-01

    Trimethylglycine at a dose of 1.5 g/kg was found to produce marked bile secretory effect in young and old rats. In rabbits with experimental atherosclerosis, trimethylglycine increased the content of biliary acids in the bile and normalized the indexes of lipid metabolism in the blood serum. Apparently, the effect on cholesterol transformation into biliary acids and its excretion with the bile is one of the mechanisms of anti-atherosclerotic action of trimethylglycine. PMID:3620644

  5. Uranium age determination - Separation and analysis of 230Th and 231Pa

    International Nuclear Information System (INIS)

    be of high chemical recovery and must afford large decontamination factors. In general, the age obtained from parent/daughter ratios refers to the last separation of the parent nuclide from its daughters, i.e. the last purification of the material. The accuracy of the obtained age therefore depends on the quality of the purification process and assumes that the material subsequently has not been contaminated. Obviously the availability of two analytical methods relying on both, independent parent/daughter pairs will therefore significantly increase the confidence in the experimental results. In this work we demonstrate analytical methods for the age determination of uranium samples using the parent/daughter relations 234U/230Th and 235U/231Pa. Thorium is separated from bulk uranium using extraction chromatography and subsequently quantified using □-spectrometry, thermal ionisation mass spectrometry (TIMS) and inductively coupled mass spectrometry (ICP-MS). Protactinium is separated by highly selective sorption of protactinium to silica gel followed by □-spectrometric quantification. The methods were tested and validated using uranium reference materials of different uranium enrichment and of known ages. The experimental results obtained with both methods were found to agree with the assumed ages of the reference materials within the combined uncertainty of the measurement. The analysis exploiting the parent/daughter pair 235U/231Pa exhibits a slightly larger combined uncertainty and bias than the thorium method but is found valuable in validating the experimental results by means of a second, independent analysis. (author)

  6. Analysis of Deformation in Inconel 718 When the Stress Anomaly and Dynamic Strain Aging Coexist

    Science.gov (United States)

    Follansbee, Paul S.

    2016-09-01

    Deformation in Inconel 718 in the presence of combined effects of the stress anomaly and dynamic strain aging is analyzed according to an internal state variable model formulation. The analysis relies on the availability of experimental data in regimes of behavior where both the stress anomaly and dynamic strain aging are absent. A model that introduces two internal state variables—one characterizing interactions of dislocations with solute atoms and one characterizing interaction of dislocations with precipitates—is shown to adequately describe the temperature and strain-rate dependence of the yield stress in several superalloy systems. Strain hardening is then added with a third internal state variable to enable description of the full stress-strain curve. These equations are extrapolated into regimes where the stress anomaly and dynamic strain aging are present to identify signatures of their effects and to compare to similar analyses in a variety of metal systems. Dynamic strain aging in Inconel 718 follows similar trends to those observed previously. The magnitude of the stress anomaly tracks measurements of stress vs test temperature in pure Ni3Al. Several trends in the strain-rate sensitivity of elevated temperature deformation in superalloys are identified based on limited availability of measurements over a wide range of strain rates or tests using strain-rate changes.

  7. Experimental Techniques for Evaluating the Effects of Aging on Impact and High Strain Rate Properties of Triaxial Braided Composite Materials

    Science.gov (United States)

    Pereira, J. Michael; Roberts, Gary D.; Ruggeri, Charles R.; Gilat, Amos; Matrka, Thomas

    2010-01-01

    An experimental program is underway to measure the impact and high strain rate properties of triaxial braided composite materials and to quantify any degradation in properties as a result of thermal and hygroscopic aging typically encountered during service. Impact tests are being conducted on flat panels using a projectile designed to induce high rate deformation similar to that experienced in a jet engine fan case during a fan blade-out event. The tests are being conducted on as-fabricated panels and panels subjected to various numbers of aging cycles. High strain rate properties are being measured using a unique Hopkinson bar apparatus that has a larger diameter than conventional Hopkinson bars. This larger diameter is needed to measure representative material properties because of the large unit cell size of the materials examined in this work. In this paper the experimental techniques used for impact and high strain rate testing are described and some preliminary results are presented for both as-fabricated and aged composites.

  8. Statistical analysis of accelerated temperature aging of semiconductor devices

    Science.gov (United States)

    Johnson, W. A.; Milles, M. F.

    1981-05-01

    A number of semiconductor devices taken from a distribution were operated at several elevated temperatures to induce failure in all devices within a reasonable time. Assuming general characteristics of the device failure probability density function (pdf) and its temperature dependence, the expected cumulative failure function (cff) for devices in normal operation were estimated based on statistical inference, taking the average probability of a random device (from the same distribution but operated at a normal temperature) failing as a function of time. A review of the mathematical formalism employed in semiconductor reliability discussions is included. Three failure pdf's at particular usefulness to this analysis--exponential, normal, and lognormal - are discussed. The cff, at times orders of magnitude loss then, at times comparable to the desired system useful, life (*10 to the 4th power to 10 to the 5th power hr) is considered. A review of accelerated temperature aging is presented, and the assumption concerning the general characteristics of the failure pdf, which are fundamental to this analysis, are emphasized.

  9. OASIS: online application for the survival analysis of lifespan assays performed in aging research.

    Directory of Open Access Journals (Sweden)

    Jae-Seong Yang

    Full Text Available BACKGROUND: Aging is a fundamental biological process. Characterization of genetic and environmental factors that influence lifespan is a crucial step toward understanding the mechanisms of aging at the organism level. To capture the different effects of genetic and environmental factors on lifespan, appropriate statistical analyses are needed. METHODOLOGY/PRINCIPAL FINDINGS: We developed an online application for survival analysis (OASIS that helps conduct various novel statistical tasks involved in analyzing survival data in a user-friendly manner. OASIS provides standard survival analysis results including Kaplan-Meier estimates and mean/median survival time by taking censored survival data. OASIS also provides various statistical tests including comparison of mean survival time, overall survival curve, and survival rate at specific time point. To visualize survival data, OASIS generates survival and log cumulative hazard plots that enable researchers to easily interpret their experimental results. Furthermore, we provide statistical methods that can analyze variances among survival datasets. In addition, users can analyze proportional effects of risk factors on survival. CONCLUSIONS/SIGNIFICANCE: OASIS provides a platform that is essential to facilitate efficient statistical analyses of survival data in the field of aging research. Web application and a detailed description of algorithms are accessible from http://sbi.postech.ac.kr/oasis.

  10. Acoustic analysis in Mudejar-Gothic churches: Experimental results

    Science.gov (United States)

    Galindo, Miguel; Zamarreño, Teófilo; Girón, Sara

    2005-05-01

    This paper describes the preliminary results of research work in acoustics, conducted in a set of 12 Mudejar-Gothic churches in the city of Seville in the south of Spain. Despite common architectural style, the churches feature individual characteristics and have volumes ranging from 3947 to 10 708 m3. Acoustic parameters were measured in unoccupied churches according to the ISO-3382 standard. An extensive experimental study was carried out using impulse response analysis through a maximum length sequence measurement system in each church. It covered aspects such as reverberation (reverberation times, early decay times), distribution of sound levels (sound strength); early to late sound energy parameters derived from the impulse responses (center time, clarity for speech, clarity, definition, lateral energy fraction), and speech intelligibility (rapid speech transmission index), which all take both spectral and spatial distribution into account. Background noise was also measured to obtain the NR indices. The study describes the acoustic field inside each temple and establishes a discussion for each one of the acoustic descriptors mentioned by using the theoretical models available and the principles of architectural acoustics. Analysis of the quality of the spaces for music and speech is carried out according to the most widespread criteria for auditoria. .

  11. Experimental analysis of particle sizes for PIV measurements

    Science.gov (United States)

    van Overbrüggen, Timo; Klaas, Michael; Soria, Julio; Schröder, Wolfgang

    2016-09-01

    The right choice of seeding particles strongly influences the outcome of a particle-image velocimetry (PIV) measurement. Particles have to scatter enough light to be seen by cameras and follow the flow faithfully. As the flow following behavior depends on the inertia and therefore the size of the particle, smaller particles are desirable. Unfortunately, larger particles possess better light scattering behavior, which is especially important for volumetric PIV measurements. In this paper, the particle response of two exemplary solid particles to an oscillatory air flow created by a piston movement is analyzed and compared to analytic results by Hjelmfelt and Mockros (1966 Appl. Sci. Res. 16 149–61) concerning phase lag and amplitude ratio between particle movement and flow field. To achieve realistic experimental boundary conditions, polydispersed particles are used for the analysis. The analytic results show a strong dependence on the diameter. That is, using the volumetric mean diameter an overestimation of the phase lag of the particles is determined, whereas an underestimation of phase lag is computed for the number mean diameter. Hence, for polydispersed particles a more general analysis than that based on the particle mean diameter is required to determine in detail the particle following behavior.

  12. Experimental analysis of particle sizes for PIV measurements

    Science.gov (United States)

    van Overbrüggen, Timo; Klaas, Michael; Soria, Julio; Schröder, Wolfgang

    2016-09-01

    The right choice of seeding particles strongly influences the outcome of a particle-image velocimetry (PIV) measurement. Particles have to scatter enough light to be seen by cameras and follow the flow faithfully. As the flow following behavior depends on the inertia and therefore the size of the particle, smaller particles are desirable. Unfortunately, larger particles possess better light scattering behavior, which is especially important for volumetric PIV measurements. In this paper, the particle response of two exemplary solid particles to an oscillatory air flow created by a piston movement is analyzed and compared to analytic results by Hjelmfelt and Mockros (1966 Appl. Sci. Res. 16 149-61) concerning phase lag and amplitude ratio between particle movement and flow field. To achieve realistic experimental boundary conditions, polydispersed particles are used for the analysis. The analytic results show a strong dependence on the diameter. That is, using the volumetric mean diameter an overestimation of the phase lag of the particles is determined, whereas an underestimation of phase lag is computed for the number mean diameter. Hence, for polydispersed particles a more general analysis than that based on the particle mean diameter is required to determine in detail the particle following behavior.

  13. Acoustic analysis in Mudejar-Gothic churches: experimental results.

    Science.gov (United States)

    Galindo, Miguel; Zamarreño, Teófilo; Girón, Sara

    2005-05-01

    This paper describes the preliminary results of research work in acoustics, conducted in a set of 12 Mudejar-Gothic churches in the city of Seville in the south of Spain. Despite common architectural style, the churches feature individual characteristics and have volumes ranging from 3947 to 10 708 m3. Acoustic parameters were measured in unoccupied churches according to the ISO-3382 standard. An extensive experimental study was carried out using impulse response analysis through a maximum length sequence measurement system in each church. It covered aspects such as reverberation (reverberation times, early decay times), distribution of sound levels (sound strength); early to late sound energy parameters derived from the impulse responses (center time, clarity for speech, clarity, definition, lateral energy fraction), and speech intelligibility (rapid speech transmission index), which all take both spectral and spatial distribution into account. Background noise was also measured to obtain the NR indices. The study describes the acoustic field inside each temple and establishes a discussion for each one of the acoustic descriptors mentioned by using the theoretical models available and the principles of architectural acoustics. Analysis of the quality of the spaces for music and speech is carried out according to the most widespread criteria for auditoria. PMID:15957758

  14. Age differences in the neural representation of working memory revealed by multi-voxel pattern analysis.

    Directory of Open Access Journals (Sweden)

    Joshua eCarp

    2010-11-01

    Full Text Available Working memory function declines across the lifespan. Computational models of aging attribute such memory impairments to reduced distinctiveness between neural representations of different mental states in old age, a phenomenon termed dedifferentiation. These models predict that neural distinctiveness should be reduced uniformly across experimental conditions in older adults. In contrast, the Compensation-Related Utilization of Neural Circuits Hypothesis (CRUNCH model predicts that the distinctiveness of neural representations should be increased in older adults (relative to young adults at low levels of task demand but reduced at high levels of demand. The present study used multi-voxel pattern analysis (MVPA to measure the effects of age and task demands on the distinctiveness of the neural representations of verbal and visuospatial working memory. Neural distinctiveness was estimated separately for memory encoding, maintenance, and retrieval, and for low, medium, and high memory loads. Results from sensory cortex during encoding and retrieval were consistent with the dedifferentiation hypothesis: distinctiveness of visual cortical representations during these phases was uniformly reduced in older adults, irrespective of memory load. However, maintenance-related responses in prefrontal and parietal regions yielded a strikingly different pattern of results. At low loads, older adults showed higher distinctiveness than younger adults; at high loads, this pattern reversed, such that distinctiveness was higher in young adults. This interaction between age group and memory load is at odds with the dedifferentiation hypothesis but consistent with CRUNCH. In sum, our results provide partial support for both dedifferentiation- and compensation-based models; we argue that comprehensive theories of cognitive aging must incorporate aspects of both models to fully explain complex patterns of age-related neuro-cognitive change.

  15. Removal of polycyclic aromatic hydrocarbons from aged-contaminated soil using cyclodextrins: Experimental study

    Energy Technology Data Exchange (ETDEWEB)

    Viglianti, Christophe [Laboratoire d' Analyse Environnementale des Procedes et des Systemes Industriels - INSA de Lyon, 9, rue de la Physique - 69621 Villeurbanne Cedex (France); Centre Sciences, Information et Technologies pour l' Environnement (SITE) - ENS de Mines de Saint Etienne, 158 cours Fauriel - 42023 Saint Etienne Cedex 2 (France); Hanna, Khalil [Laboratoire d' Analyse Environnementale des Procedes et des Systemes Industriels - INSA de Lyon, 9, rue de la Physique - 69621 Villeurbanne Cedex (France)]. E-mail: khalilhanna@hotmail.com; Brauer, Christine de [Laboratoire d' Analyse Environnementale des Procedes et des Systemes Industriels - INSA de Lyon, 9, rue de la Physique - 69621 Villeurbanne Cedex (France); Germain, Patrick [Laboratoire d' Analyse Environnementale des Procedes et des Systemes Industriels - INSA de Lyon, 9, rue de la Physique - 69621 Villeurbanne Cedex (France)

    2006-04-15

    The removal of polycyclic aromatic hydrocarbons (PAHs) from soil using water as flushing agent is relatively ineffective due to their low aqueous solubility. However, addition of cyclodextrin (CD) in washing solutions has been shown to increase the removal efficiency several times. Herein are investigated the effectiveness of cyclodextrin to remove PAH occurring in industrially aged-contaminated soil. {beta}-Cyclodextrin (BCD), hydroxypropyl-{beta}-cyclodextrin (HPCD) and methyl-{beta}-cyclodextrin (MCD) solutions were used for soil flushing in column test to evaluate some influent parameters that can significantly increase the removal efficiency. The process parameters chosen were CD concentration, ratio of washing solution volume to soil weight, and temperature of washing solution. These parameters were found to have a significant and almost linear effect on PAH removal from the contaminated soil, except the temperature where no significant enhancement in PAH extraction was observed for temperature range from 5 to 35 {sup o}C. The PAHs extraction enhancement factor compared to water was about 200. - An innovative method using a biodegradable and non-toxic flushing agent for the depollution of industrially aged-contaminated soil.

  16. Justification for experimental methods for circuit training aerobics classes first mature age women

    Directory of Open Access Journals (Sweden)

    Martyniuk O.V.

    2014-11-01

    Full Text Available Purpose: develop and validate a methodology for circuit training aerobics. Methodology focused on improving physical health first mature age women. Material : a study was conducted with 81 women (age 21 - 35 years. Results : justified the means and methods of circuit training, the duration of the structural components, the rational parameters of physical activity, pulse modes. Depending on the physical health of women developed a set of circuit training for the main part of the session. Complex circuit training consists of 2 series, active rest interval between 3 minutes. Duration of employment in one series of 23 minutes. Exercises are performed at 5 locations: 3 - aerobic (3x5 min, 2 - power (2x4 min. The total duration of training - 49 minutes. The intensity of the training load is regulated by the level of physical health and the maximum test results. Conclusions : The positive changes morphofunctional indicators show an increase in the body's bioenergy and women transition to a higher level of physical health.

  17. Eleutheroside B or E enhances learning and memory in experimentally aged rats

    Institute of Scientific and Technical Information of China (English)

    Debin Huang; Zehua Hu; Zhaofen Yu

    2013-01-01

    Eleutheroside B or E, the main component of Acanthopanax, can relieve fatigue, enhance memory, and improve human cognition. Numerous studies have confirmed that high doses of acetylcholine significantly attenuate clinical symptoms and delay the progression of Alzheimer's disease. The present study replicated a rat model of aging induced by injecting quinolinic acid into the hippocampal CA1 region. These rats were intraperitoneally injected with low, medium and high doses of eleutheroside B or E (50, 100, 200 mg/kg), and rats injected with Huperzine A or PBS were used as controls. At 4 weeks after administration, behavioral tests showed that the escape latencies and errors in searching for the platform in a Morris water maze were dose-dependently reduced in rats treated with medium and high-dose eleutheroside B or E. Hematoxylin-eosin staining showed that the number of surviving hippocampal neurons was greater and pathological injury was milder in three eleutheroside B or E groups compared with model group. Hippocampal homogenates showed enhanced cholinesterase activity, and dose-dependent increases in acetylcholine content and decreases in choline content following eleutheroside B or E treatment, similar to those seen in the Huperzine A group. These findings indicate that eleutheroside B or E improves learning and memory in aged rats. These effects of eleutheroside B or E may be mediated by activation of cholinesterase or enhanced reuse of choline to accelerate the synthesis of acetylcholine in hippocampal neurons.

  18. Transparent Meta-Analysis of Prospective Memory and Aging

    OpenAIRE

    Bob Uttl

    2008-01-01

    Prospective memory (ProM) refers to our ability to become aware of a previously formed plan at the right time and place. After two decades of research on prospective memory and aging, narrative reviews and summaries have arrived at widely different conclusions. One view is that prospective memory shows large age declines, larger than age declines on retrospective memory (RetM). Another view is that prospective memory is an exception to age declines and remains invariant across the adult lifes...

  19. Differentiation, ageing, and terminal differentiation: a semantic analysis.

    Science.gov (United States)

    Reiner, J M

    1983-12-21

    The largely unsolved problems in the theoretical analysis of differentiation and ageing involve a substantial component of linguistic (semantic) difficulties. Some of these are simple traps of ambiguity, resulting from metaphorical or analogical employment of established terms--for example, "terminal differentiation" (loss of division potential in vitro) as a borrowing from "differentiation" as used by developmental biologists, or "commitment" by analogy with "determination". Some difficulties represent a failure to adopt (at least provisionally) an operational (empirical) view--for example, failure to ask what is the nature of the evidence for the view that a fertilized ovum is totipotential, or to scrutinize the evidence for the view that cells "terminally differentiated" in vitro in a conventional medium are in fact moribund under all conditions, or to examine more closely the view that the differentiated state and the cycling state are mutually exclusive. With respect to the problem of ageing, we review some of the critical experiments on "terminal differentiation" or "clonal senescence". We then proceed to consider some of the models that have been proposed, including a molecular model proposed by the author which appears to overcome some of the objections to other models. Some of the models exemplify the results of what are ultimately semantic vices. The problems with which these remarks began should indeed yield to the immense and novel resources of molecular biology. But the development of complete analyses demands not only good luck and delicate technique but also critical semantic clarity and severity. Given the best tools, we shall solve major theoretical problems only if we understand quite fully what problem it is that we are trying to solve--and the history of science illustrates that this is not as elementary a matter as it sounds.(ABSTRACT TRUNCATED AT 250 WORDS)

  20. [Composition and metabolism of extremely low-density lipoproteins in normal rabbits of different age and under experimental atherosclerosis].

    Science.gov (United States)

    Chaialo, P P

    1981-01-01

    The lipid composition and protein content in extremely low-density lipoproteids. lipoproteid-lypase activity and breakdown dynamics of the mentioned [3H]cholesterol-labelled lipoproteids are studied in blood of young and old rabbits in norm and under experimental atherosclerosis. It is shown that in normal animals the content of all lipid components and protein decreases with ageing in the fraction of extremely low-density lipoproteids isolated from blood serum. The activity of lipoproteid lypase and breakdown of intravenously injected labelled extremely low-density lipoproteids are lowered in old animals as well. Under experimental atherosclerosis in extremely low-density lipoproteids there occurs accumulation of cholesterol esters in considerable amounts, the breakdown of the class lipoproteids is slown down. The enzymic activity manifests no significant changes in comparison with the norm. Disturbances in the composition of lipoproteids and their metabolism with the studied pathology are more pronounced in old rabbits than in young ones.

  1. Multivariate Analysis for Animal Selection in Experimental Research

    Directory of Open Access Journals (Sweden)

    Renan Mercuri Pinto

    2015-02-01

    Full Text Available Background: Several researchers seek methods for the selection of homogeneous groups of animals in experimental studies, a fact justified because homogeneity is an indispensable prerequisite for casualization of treatments. The lack of robust methods that comply with statistical and biological principles is the reason why researchers use empirical or subjective methods, influencing their results. Objective: To develop a multivariate statistical model for the selection of a homogeneous group of animals for experimental research and to elaborate a computational package to use it. Methods: The set of echocardiographic data of 115 male Wistar rats with supravalvular aortic stenosis (AoS was used as an example of model development. Initially, the data were standardized, and became dimensionless. Then, the variance matrix of the set was submitted to principal components analysis (PCA, aiming at reducing the parametric space and at retaining the relevant variability. That technique established a new Cartesian system into which the animals were allocated, and finally the confidence region (ellipsoid was built for the profile of the animals’ homogeneous responses. The animals located inside the ellipsoid were considered as belonging to the homogeneous batch; those outside the ellipsoid were considered spurious. Results: The PCA established eight descriptive axes that represented the accumulated variance of the data set in 88.71%. The allocation of the animals in the new system and the construction of the confidence region revealed six spurious animals as compared to the homogeneous batch of 109 animals. Conclusion: The biometric criterion presented proved to be effective, because it considers the animal as a whole, analyzing jointly all parameters measured, in addition to having a small discard rate.

  2. Ageing, Health and Life Satisfaction of the Oldest Old: An Analysis for Germany

    Science.gov (United States)

    Gwozdz, Wencke; Sousa-Poza, Alfonso

    2010-01-01

    This analysis uses data from the German Socio-Economic Panel and the Survey on Health, Ageing and Retirement in Europe to assess the effect of ageing and health on the life satisfaction of the oldest old (defined as 75 and older). We observe a U-shaped relationship between age and levels of life satisfaction for individuals aged between 16 and 65.…

  3. Aging Chart: a community resource for rapid exploratory pathway analysis of age-related processes

    OpenAIRE

    Moskalev, Alexey; Zhikrivetskaya, Svetlana; Shaposhnikov, Mikhail; Dobrovolskaya, Evgenia; Gurinovich, Roman; Kuryan, Oleg; Pashuk, Aleksandr; Jellen, Leslie C.; Aliper, Alex; Peregudov, Alex; Zhavoronkov, Alex

    2015-01-01

    Aging research is a multi-disciplinary field encompassing knowledge from many areas of basic, applied and clinical research. Age-related processes occur on molecular, cellular, tissue, organ, system, organismal and even psychological levels, trigger the onset of multiple debilitating diseases and lead to a loss of function, and there is a need for a unified knowledge repository designed to track, analyze and visualize the cause and effect relationships and interactions between the many elemen...

  4. Genetic analysis of experimental allergic encephalomyelitis in mice

    Energy Technology Data Exchange (ETDEWEB)

    Baker, D.; Rosenwasser, O.A.; O`Neill, J.K.; Turk, J.L. [Royal College of Surgeons of England, London (United Kingdom)

    1995-10-15

    Experimental allergic encephalomyelitis (EAE) is an autoimmune disease of the central nervous system that exhibits many pathologic similarities with multiple sclerosis. While products of the MHC are known to control the development of EAE, it is clear that non-MHC products also influence susceptibility. The chromosomal locations of these were investigated in selective crosses between MHC class II-compatible, EAE-susceptible Biozzi ABH, and low responder nonobese diabetic (NOD) mice. The disease was dominant and highly influenced by gender in the backcross one (BC{sub 1}) generation. Female mice were significantly more susceptible than male mice. Segregation of disease frequency of female animals in this cross suggested that EAE was controlled by a major locus. Although microsatellite-based exclusion mapping indicated that a number of regions on chromosomes 5, 6, 7, 8, 9, 10, 11, 12, 13, and 18 showed evidence of linkage (p<0.05) compared with expected random distributions of alleles, disease susceptibility was most strongly linked (p<0.05) to chromosome 7. However, by selectively analyzing animals that were either severely affected or almost normal, additional susceptibility loci were mapped on chromosomes 18 and 11 that were linked (p<0.001) to resistance and the development of severe disease, respectively. The data indicate a major locus on chromosome 7, affecting initiation and severity of EAE that is probably modified by several other unlinked loci. These localizations may provide candidate loci for the analysis of human autoimmune-demyelinating disease. 30 refs., 5 tabs.

  5. Uniaxial Fatigue of HDPE-100 Pipe. Experimental Analysis

    Directory of Open Access Journals (Sweden)

    A. Aid

    2014-04-01

    Full Text Available In this paper, an experimental analysis for determining the fatigue strength of PE-100, one of the most used High Density Polyethylene (HDPE materials for pipes, under cyclic axial loadings is presented. HDPE is a thermoplastic material used for piping systems, such as natural gas distribution systems, sewer systems and cold water systems, which provides a good alternative to metals such as cast iron or carbon steel. One of the causes for failures of HDPE pipes is fatigue which is the result of pipes being subjected to cyclic loading, such as internal pressure, weight loads or external loadings on buried pipes, which generate stress in different directions: circumferential, longitudinal and radial. HDPE pipes are fabricated using an extrusion process, which generates anisotropic properties. By testing in the Laboratory a series of identical specimens obtained directly from PE-100 HDPE pipes in longitudinal directions, the relationships between amplitude stress and number of cycles (S-N curve test frequency 2 Hz and stress ratio R = 0.0 are established.

  6. A Novel Linear Switched Reluctance Machine: Analysis and Experimental Verification

    Directory of Open Access Journals (Sweden)

    N. C. Lenin

    2010-01-01

    Full Text Available The important problems to be solved in Linear Switched Reluctance Machines (LSRMs are: (1 to design the shape and size of poles in stator and translator cores; (2 to optimize their geometrical configuration. A novel stator geometry for LSRMs that improved the force profile was presented in this study. In the new geometry, pole shoes were affixed on the stator poles. Static and dynamic characteristics for the proposed structure had been highlighted using Two Dimensional (2-D Finite Element Analyses (FEA. Motor performance for variable load conditions was discussed. The finite element analyses and the experimental results of this study proved that, LSRMs were one of the strong candidates for linear propulsion drives. Problem statement: To mitigate the force ripple without any loss in average force and force density. Approach: Design modifications in the magnetic structures. Results: 2-D finite element analysis was used to predict the performance of the studied structures. Conclusion/Recommendations: The proposed structure not only reduces the force ripple, also reduced the volume and mass. The future study is to make an attempt on vibration, thermal and stress analyses.

  7. Experimental analysis of a new retarding field energy analyzer

    Energy Technology Data Exchange (ETDEWEB)

    Wei, Yu-Xiang [Shanghai Institute of Mechanical and Electrical Engineering, No. 3888, Yuanjiang Road, Minhang District, Shanghai 201109 (China); Institute of Electronics, Chinese Academy of Sciences, No. 19, North 4th Ring Road West, Haidian District, Beijing 100190 (China); Liu, Shu-Qing; Li, Xian-Xia; Shen, Hong-Li; Huang, Ming-Guang [Institute of Electronics, Chinese Academy of Sciences, No. 19, North 4th Ring Road West, Haidian District, Beijing 100190 (China); Liu, Pu-Kun, E-mail: pkliu@pku.edu.cn [School of Electronics Engineering and Computer Science, Peking University, No. 5, Yiheyuan Road, Haidian District, Beijing 100871 (China)

    2015-06-11

    In this paper, a new compact retarding field energy analyzer (RFEA) is designed for diagnosing electron beams of a K-band space travelling-wave tube (TWT). This analyzer has an aperture plate to sample electron beams and a cylindrical electrode to overcome the defocusing effects. The front end of the analyzer constructed as a multistage depression collector (MDC) structure is intended to shape the field to prevent electrons from being accelerated to escape. The direct-current (DC) beams of the K-band space TWTs with the removing MDC can be investigated on the beam measurement system. The current density distribution of DC beams is determined by the analyzer, while the anode voltage and helix voltage of the TWTs are 7000 V and 6850 V, respectively. The current curve’s slope effect due to the reflection of secondary electrons on the copper collector of the analyzer is discussed. The experimental analysis shows this RFEA has a good energy resolution to satisfy the requirement of beam measurement. - Highlights: • A new retarding field energy analyzer (RFEA) is designed to diagnose the electron beam of a K-band space TWT. • The current density distribution of direct-current beam is determined. • The reflection effect of secondary electrons on the copper collector of the analyzer is discussed.

  8. Nuclear analysis of a tokamak experimental power reactor conceptual design

    International Nuclear Information System (INIS)

    Detailed nuclear analysis of a reference conceptual design for a tokamak experimental power reactor (EPR) is presented. The reference EPR has a 6.25-m major radius and a 2.1-m minor radius circular plasma with a nominal neutron wall loading of 0.5 MW/m2. A 0.28-m-thick blanket of stainless steel surrounds a stainless-steel vacuum vessel. The inner shield consists of stainless steel and B4C and is 0.58 m thick. The 0.97-m-thick outer shield employs lead mortar, stainless steel, and graphite. The neutronics results in the first wall and blanket vary significantly in the poloidal direction due to an outward shift in the deuterium-tritium neutron source distribution and the toroidal curvature. The infinite cylinder approximation overestimates response rates in the first wall compared with toroidal geometry calculations. Neutral beam lines, vacuum ducts, and other penetrations of the blanket and bulk shield represent large (approximately 0.6- to 1.0-m2 cross section) streaming paths for neutrons and require special shielding. A special 0.75-m-thick annular shield surrounds the neutral beam duct after it exists from the bulk shield and extends beyond the toroidal field coil and out to the beam injectors. A pneumatically operated movable shield plug, opening during the pumpdown phase and closing during the plasma burn, is selected as the principal design option for shielding the evacuation ducts

  9. Analysis of experimental studies on gully erosion: a global review

    Science.gov (United States)

    Castillo, Carlos; Gómez, Jose A.

    2015-04-01

    Research on gully erosion has increased significantly in the last decades. Despite the growing interest on the topic, relevant knowledge gaps still remain a challenge for gully erosion researchers (Poesen, 2011). Moreover, many of these studies are mainly descriptive, with little quantitative data allowing a comparison of the severity of the processes among different environments and conditions. The aim of this communication is to analyse the available experimental data in gully erosion literature involving quantitative information from the Web of Science datasets. Our objective is to investigate relevant trends of this type of erosion on the world scale. We have evaluated the role of gully erosion in the overall soil losses as well as the magnitude of the morphological variables. Also, we analysed the characteristics of image-based and field surveys regarding the technique employed, duration and data collection frequency. In this communication, we intend to provide insights on the evolution of gully erosion research up to the present moment in order to gain perspectives on the design of future efforts in the topic. References Poesen, J. 2011. Challenges in gully erosion research. Landform Analysis, Vol. 17: 5-9.

  10. Removal of polycyclic aromatic hydrocarbons from aged-contaminated soil using cyclodextrins: experimental study

    Energy Technology Data Exchange (ETDEWEB)

    Christophe Viglianti; Khalil Hanna; Christine de Brauer; Patrick Germain [Laboratoire d' Analyse Environnementale des Procedes et des Systemes Industriels - INSA de Lyon, Villeurbanne (France)

    2006-04-15

    The removal of polycyclic aromatic hydrocarbons (PAHs) from soil using water as flushing agent is relatively ineffective due to their low aqueous solubility. However, addition of cyclodextrin (CD) in washing solutions has been shown to increase the removal efficiency several times. Herein are investigated the effectiveness of cyclodextrin to remove PAH occurring in industrially aged-contaminated soil. {beta}-Cyclodextrin (BCD), hydroxypropyl-{beta}-cyclodextrin (HPCD) and methyl-{beta}-cyclodextrin (MCD) solutions were used for soil flushing in column test to evaluate some influent parameters that can significantly increase the removal efficiency. The process parameters chosen were CD concentration, ratio of washing solution volume to soil weight, and temperature of washing solution. These parameters were found to have a significant and almost linear effect on PAH removal from the contaminated soil, except the temperature where no significant enhancement in PAH extraction was observed for temperature range from 5 to 35{sup o}C. The PAHs extraction enhancement factor compared to water was about 200.

  11. Lap Shear and Impact Testing of Ochre and Beeswax in Experimental Middle Stone Age Compound Adhesives.

    Science.gov (United States)

    Kozowyk, P R B; Langejans, G H J; Poulis, J A

    2016-01-01

    The production of compound adhesives using disparate ingredients is seen as some of the best evidence of advanced cognition outside of the use of symbolism. Previous field and laboratory testing of adhesives has shown the complexities involved in creating an effective Middle Stone Age glue using Acacia gum. However, it is currently unclear how efficient different adhesive recipes are, how much specific ingredients influence their performance, and how difficult it may have been for those ingredients to be combined to maximum effect. We conducted a series of laboratory-based lap shear and impact tests, following modern adhesion testing standards, to determine the efficacy of compound adhesives, with particular regard to the ingredient ratios. We tested rosin (colophony) and gum adhesives, containing additives of beeswax and ochre in varying ratios. During both lap shear and impact tests compound rosin adhesives performed better than single component rosin adhesives, and pure acacia gum was the strongest. The large difference in performance between each base adhesive and the significant changes in performance that occur due to relatively small changes in ingredient ratios lend further support to the notion that high levels of skill and knowledge were required to consistently produce the most effective adhesives.

  12. A comparative analysis of root dentin transparency with known age

    Directory of Open Access Journals (Sweden)

    Anita Singhal

    2010-01-01

    Full Text Available Objective: To correlate dimensions of root transparency and age, and to assess whether transparency is reliable for age estimation of unknown. Materials and Methods: 50 freshly extracted single rooted permanent teeth from 50 different individuals (27 males and 23 females were collected and their ground sections of 400 ΅m were stained with 1% methylene blue. The area of the translucent zone was measured by superimposing a transparent graph paper on the ground section under stereomicroscope. The length of the translucency was measured by using digital vernier caliper. Results: A strong positive correlation between age and translucency of dentin was noted. The length rather than the area of the translucent zone correlated more with age. Conclusion: Translucency of the root dentin increases with age and it can be used as a reliable parameter for the age estimation.

  13. Preliminary result on the analysis of Late Bronze Age metals

    International Nuclear Information System (INIS)

    Complete text of publication follows. The main event of the complex cultural changes during the transition from Middle to Late Bronze Age was the appearance of Tumulus culture in the Danube-Tisza region. In this period people rose mounds (tumuli) above their graves made from stone and soil. According to our present knowledge we believe that the ethnically inhomogeneous Tumulus culture was made homogenous by commerce (especially bronze commerce). Depots were typical of the final period of Middle Bronze Age called Koszider-phase. During the tumulus period the practice of hiding depots came to its end, bronze objects were put into graves. Therefore, it would be important to analyze the relation between the Koszider and Tumulus metallurgy. The main question to be answered is the following: were the trade connections and exchange of goods discontinued during the time of cultural changes? Examination of archaeological finds is carried out usually by typological methods which provide information on the attire fashion and funeral rite of cultures. The inherent capability of analytical techniques makes it possible to draw conclusions on the provenance of metals, thus facilitating to establish the contemporary trade routes. The metal finds from the southern part of the Great Hungarian Plain has not been investigated yet, though it would be important from the point of view of Tumulus culture. The main question is whether there is any noticeable change between the metallurgical craftsmanship of the consecutive eras. Therefore, it is important to determine the composition of the used raw materials, their sources, as well as the applied manufacturing technologies. For the characterization of archaeological bronze finds both conventional X-ray fluorescence (XRF) method and micro proton induced X-ray fluorescence (micro-PIXE) techniques are applied. The first one serves for the determination of the bulk composition of samples while the second one for the characterization of

  14. Development of an experimental apparatus for nucleate boiling analysis

    International Nuclear Information System (INIS)

    An experimental apparatus is developed for the study of the parameters that affect nucleate boiling. The experimental set up is tested for nucleate boiling in an annular test section with subcooled water flow. The following parameters are analysed: pressure, fluid velocity and the fluid temperature at the test section entrance. The performance of the experimental apparatus is analysed by the results and by the problems raised by the operation of the setup. (Author)

  15. Experimental stress analysis for materials and structures stress analysis models for developing design methodologies

    CERN Document Server

    Freddi, Alessandro; Cristofolini, Luca

    2015-01-01

    This book summarizes the main methods of experimental stress analysis and examines their application to various states of stress of major technical interest, highlighting aspects not always covered in the classic literature. It is explained how experimental stress analysis assists in the verification and completion of analytical and numerical models, the development of phenomenological theories, the measurement and control of system parameters under operating conditions, and identification of causes of failure or malfunction. Cases addressed include measurement of the state of stress in models, measurement of actual loads on structures, verification of stress states in circumstances of complex numerical modeling, assessment of stress-related material damage, and reliability analysis of artifacts (e.g. prostheses) that interact with biological systems. The book will serve graduate students and professionals as a valuable tool for finding solutions when analytical solutions do not exist.

  16. A roadmap for the genetic analysis of renal aging

    NARCIS (Netherlands)

    Noordmans, Gerda A.; van Goor, Harry; Hillebrands, Jan-Luuk; Korstanje, Ron

    2015-01-01

    Several studies show evidence for the genetic basis of renal disease, which renders some individuals more prone than others to accelerated renal aging. Studying the genetics of renal aging can help us to identify genes involved in this process and to unravel the underlying pathways. First, this opin

  17. Case-control analysis of paternal age and trisomic anomalies

    DEFF Research Database (Denmark)

    De Souza, E; Morris, David Jackson; Garne, Ester

    2010-01-01

    To determine whether older paternal age increases the risk of fathering a pregnancy with Patau (trisomy 13), Edwards (trisomy 18), Klinefelter (XXY) or XYY syndrome.......To determine whether older paternal age increases the risk of fathering a pregnancy with Patau (trisomy 13), Edwards (trisomy 18), Klinefelter (XXY) or XYY syndrome....

  18. Materialism across the lifespan : An age-period-cohort analysis

    NARCIS (Netherlands)

    Jaspers, Esther; Pieters, Rik

    2016-01-01

    This research examined the development of materialism across the lifespan. Two initial studies revealed that: 1) lay beliefs were that materialism declines with age; and 2) previous research findings also implied a modest, negative relationship between age and materialism. Yet, previous research has

  19. Analysis on age structure of Zoysia japonica(Poaceae) population

    Institute of Scientific and Technical Information of China (English)

    WANGYan; DAIBao-qing; LIANGYong-jun; MALian-ju

    2003-01-01

    The age-structure of natural population of Zoysia japonica in Xiuyan County of Liaoning Province was studied by generational method.The results showed that the highest tiller age class was three,but 1st age class tillers held dominant position with proportions over 95% in each month during the growing seasons.The 2nd age class and 2rd age class tillers were minority in the population.So Z.japonica population was an expanding population.The zero age class buds on the rhizomes were dominantin buds age structures.The proportion of buds to tillers on quantity in each month was about 30% to 40% and reached the highest at the end of September.The increasing of buds proportion before dormancy guaranteed the quantity of tillers in the next spring.The biomass of 1st age class tillers changed with time.The biomass kept increasing from April to July and reached the highest at the end of July and then decreased.

  20. AGEING POPULATION: COMPARATIVE ANALYSIS AMONG EUROPEAN UNION STATES

    Directory of Open Access Journals (Sweden)

    Laura DIACONU (MAXIM

    2015-03-01

    Full Text Available The aging population is a global phenomenon, which has affected almost all the EU states. The consequences are very important since it affects the socio-economic environment usually on the long run. Some of them could consist in increasing the public expenditure on pensions, social security and health services, which will raise the overall burden on the working population. Sometimes, a significant reduction of the labour force will even diminish the growth rate of an economy. Considering these aspects, the present paper intends to analyse the demographic situation from the EU states, the factors that have generated it and to identify the possible future trends. To determine the evolution of the ageing population phenomenon, we have analysed some demographic indicators included in various statistical reports and databases, such as the fertility rate, the median age, the percentage of population over a certain age and the age dependency ratio.

  1. Experimental Analysis of Stochastic Resonance in a Duffing System

    Institute of Scientific and Technical Information of China (English)

    WANG Fu-Zhong; CHEN Wei-Shi; QIN Guang-Rong; GUO De-Yong; LIU Jun-Ling

    2003-01-01

    An experimental circuit is used to study the stochastic resonance (SR) phenomena in a Duffing system. The characteristics ofSR are investigated from various aspects by varying all the possible parameters. The deviations between the experimental results and the adiabatic theory are presented.

  2. Ar-39-Ar-40 Ages of Two Nakhlites, MIL03346 and Y000593: A Detailed Analysis

    Science.gov (United States)

    Park, Jisun; Garrison, Daniel; Bogard, Donald

    2007-01-01

    Radiometric dating of martian nakhlites by several techniques have given similar ages of approx.1.2-1.4 Ga [e.g. 1, 2]. Unlike the case with shergottites, where the presence of martian atmosphere and inherited radiogenic Ar-40 produce apparent Ar-39-Ar-40 ages older than other radiometric ages, Ar-Ar ages of nakhlites are similar to ages derived by other techniques. However, even in some nakhlites the presence of trapped martian Ar produces some uncertainty in the Ar-Ar age. We present here an analysis of such Ar-Ar ages from the MIL03346 and Y000593 nakhlites.

  3. Towards experimental validation of an analysis framework for morphing radiators

    Science.gov (United States)

    Bertagne, Christopher L.; Erickson, Lisa R.; Sheth, Rubik B.; Whitcomb, John D.; Hartl, Darren J.

    2016-04-01

    Thermal control is an important aspect of spacecraft design, particularly in the case of crewed vehicles, which must maintain a precise internal temperature at all times in spite of sometimes drastic variations in the external thermal environment and internal heat loads. The successes of the Space Shuttle and International Space Station programs have shown that this can be accomplished in Low Earth Orbit (LEO), however, crewed spacecraft traveling beyond LEO are expected to encounter more challenging thermal conditions with significant variations in both the heat rejection requirements and environment temperature. Such missions will require radiator systems with high turndown ratios, defined as the ratio between the maximum and minimum heat rejection rates achievable by the radiator system. Current radiators are only able to achieve turndown ratios of 3:1, far less than the 12:1 turndown ratio which is expected to be required on future missions. An innovative radiator concept, known as a morphing radiator, uses the temperature-induced shape change of shape memory alloy (SMA) materials to achieve a turndown ratio of at least 12:1. Predicting the thermal and structural behavior of SMA-based morphing radiators is challenging due to the presence of two-way thermomechanical coupling that has not been widely considered in the literature. Previous work has demonstrated the application of a technique known as a partitioned analysis procedure which can be used to simulate the behavior of morphing radiators. This work describes ongoing efforts to evaluate the physical accuracy of this approach by conducting validation studies. A detailed finite element model of a morphing radiator is developed and executed using the framework. Preliminary results show close agreement between the experimental data and model predictions, giving additional confidence in the partitioned approach.

  4. Experimental investigations for uncertainty quantification in brake squeal analysis

    Science.gov (United States)

    Renault, A.; Massa, F.; Lallemand, B.; Tison, T.

    2016-04-01

    The aim of this paper is to improve the correlation between the experimental and the numerical prediction of unstable frequencies for automotive brake systems considering uncertainty. First, an experimental quantification of uncertainty and a discussion analysing the contributions of uncertainty to a numerical squeal simulation are proposed. Frequency and transient simulations are performed considering nominal values of model parameters, determined experimentally. The obtained results are compared with those derived from experimental tests to highlight the limitation of deterministic simulations. The effects of the different kinds of uncertainty detected in working conditions of brake system, the pad boundary condition, the brake system material properties and the pad surface topography are discussed by defining different unstable mode classes. Finally, a correlation between experimental and numerical results considering uncertainty is successfully proposed for an industrial brake system. Results from the different comparisons reveal also a major influence of the pad topography and consequently the contact distribution.

  5. Analysis on Menarche Age of Chinese Reproductive Women

    Institute of Scientific and Technical Information of China (English)

    武俊青; 高尔生; 张子豹

    2000-01-01

    Objectives To analyze the age of menarche of Chinese reproductive women and some related factors.Material & Methods The data used in this paper was collected through “National Demography and Reproductive Health Survey” of China in 1997.Results The menarche age declined successively and dramatically, from 16. 45 years of the women born in 194 7~1949 to 13. 86 of those born in 1980~1982, decreasing by 0. 65 years per decade.Conclusions The results revealed that some factors such as residence, year of birth,nationality, education level and living region had effects on the menarche age.

  6. Analysis on Menarche Age of Chinese Reproductive Women

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Objectives To analyze the age of menarche of Chinese reproductive women and some related factors. Material & Methods The data used in this paper was collected through "National Demography and Reproductive Health Survey" of China in 1997. Results The menarche age declined successively and dramatically, from 16. 45 years of the women born in 1947~1949 to 13. 86 of those born in 1980~1982, decreasing by 0. 65 years per decade. Conclusions The results revealed that some factors such as residence, year of birth, nationality, education level and living region had effects on the menarche age.

  7. Comparative analysis of old-age mortality estimations in Africa.

    Directory of Open Access Journals (Sweden)

    Eran Bendavid

    Full Text Available BACKGROUND: Survival to old ages is increasing in many African countries. While demographic tools for estimating mortality up to age 60 have improved greatly, mortality patterns above age 60 rely on models based on little or no demographic data. These estimates are important for social planning and demographic projections. We provide direct estimations of older-age mortality using survey data. METHODS: Since 2005, nationally representative household surveys in ten sub-Saharan countries record counts of living and recently deceased household members: Burkina Faso, Côte d'Ivoire, Ethiopia, Namibia, Nigeria, Swaziland, Tanzania, Uganda, Zambia, and Zimbabwe. After accounting for age heaping using multiple imputation, we use this information to estimate probability of death in 5-year intervals ((5q(x. We then compare our (5q(x estimates to those provided by the World Health Organization (WHO and the United Nations Population Division (UNPD to estimate the differences in mortality estimates, especially among individuals older than 60 years old. FINDINGS: We obtained information on 505,827 individuals (18.4% over age 60, 1.64% deceased. WHO and UNPD mortality models match our estimates closely up to age 60 (mean difference in probability of death -1.1%. However, mortality probabilities above age 60 are lower using our estimations than either WHO or UNPD. The mean difference between our sample and the WHO is 5.9% (95% CI 3.8-7.9% and between our sample is UNPD is 13.5% (95% CI 11.6-15.5%. Regardless of the comparator, the difference in mortality estimations rises monotonically above age 60. INTERPRETATION: Mortality estimations above age 60 in ten African countries exhibit large variations depending on the method of estimation. The observed patterns suggest the possibility that survival in some African countries among adults older than age 60 is better than previously thought. Improving the quality and coverage of vital information in developing

  8. Comparative Analysis of Old-Age Mortality Estimations in Africa

    Science.gov (United States)

    Bendavid, Eran; Seligman, Benjamin; Kubo, Jessica

    2011-01-01

    Background Survival to old ages is increasing in many African countries. While demographic tools for estimating mortality up to age 60 have improved greatly, mortality patterns above age 60 rely on models based on little or no demographic data. These estimates are important for social planning and demographic projections. We provide direct estimations of older-age mortality using survey data. Methods Since 2005, nationally representative household surveys in ten sub-Saharan countries record counts of living and recently deceased household members: Burkina Faso, Côte d'Ivoire, Ethiopia, Namibia, Nigeria, Swaziland, Tanzania, Uganda, Zambia, and Zimbabwe. After accounting for age heaping using multiple imputation, we use this information to estimate probability of death in 5-year intervals (5qx). We then compare our 5qx estimates to those provided by the World Health Organization (WHO) and the United Nations Population Division (UNPD) to estimate the differences in mortality estimates, especially among individuals older than 60 years old. Findings We obtained information on 505,827 individuals (18.4% over age 60, 1.64% deceased). WHO and UNPD mortality models match our estimates closely up to age 60 (mean difference in probability of death -1.1%). However, mortality probabilities above age 60 are lower using our estimations than either WHO or UNPD. The mean difference between our sample and the WHO is 5.9% (95% CI 3.8–7.9%) and between our sample is UNPD is 13.5% (95% CI 11.6–15.5%). Regardless of the comparator, the difference in mortality estimations rises monotonically above age 60. Interpretation Mortality estimations above age 60 in ten African countries exhibit large variations depending on the method of estimation. The observed patterns suggest the possibility that survival in some African countries among adults older than age 60 is better than previously thought. Improving the quality and coverage of vital information in developing countries will become

  9. A meta-analysis on experimental infections with porcine circovirus type 2 (PCV2).

    Science.gov (United States)

    Tomás, Anna; Fernandes, Lana T; Valero, Oliver; Segalés, Joaquim

    2008-12-10

    A meta-analysis was performed with the aim to identify factors with a relevant influence on the expression of clinical postweaning multisystemic wasting syndrome (PMWS) under experimental conditions. Data from 44 studies were included in the analysis. Several variables were studied: number of pigs in the experiment, intake of colostrum, serological status against porcine circovirus type 2 (PCV2), strain of PCV2 used for inoculation, the route and dose of inoculation, and use of potential triggering factors (such as co-infections, vaccinations, or immunomodulator products). Multiple correspondence analysis and log-linear regression methods were used to establish the relationships between the studied variables and the number of PCV2 infected pigs that developed PMWS. Based on the results of the meta-analysis, the most successful animal experiment aimed to develop PMWS should include: (1) colostrum-deprived pigs, (2) age of inoculation below 3 weeks, (3) high doses of PCV2 inoculum, (4) PCV2 strain from genotype 1, and (5) co-infection with another swine pathogen as a triggering factor.

  10. Anonymity in a Limit-Order Market: An Experimental Analysis

    OpenAIRE

    Majois, Christophe

    2008-01-01

    In this paper, we adopt an experimental approach to evaluate the impact of pre-trade anonymity in order-driven markets. More specifically, we build an experimental design of an electronic limit-order market, and compare two settings: one in which traders observe the identities of agents placing orders in the order book, and the other one where this information is not available on market screens. We find that ID code disclosure does not alter liquidity, efficiency or traders’ pr...

  11. Dynamic Insulation Systems: Experimental Analysis on a Parietodynamic Wall

    OpenAIRE

    Serra, Valentina; Fantucci, Stefano; Perino, Marco

    2015-01-01

    This paper shows the results of an extensive experimental campaign on a ventilated opaque double skin façade based on hollow clay bricks. The winter thermal performances of the dynamic insulated systems were investigated on two different full scale façade configurations through an experimental campaign in double climatic chamber and guarded heat flow meter apparatus. The laboratory tests on dynamic insulated façade (DIF) in both exhaust and supply configurations show respectively an effective...

  12. An Analysis on the Spatial Distribution of Population Aging Pressure in China

    Institute of Scientific and Technical Information of China (English)

    YangWangzhou; Dong Suocheng; Wu Youde; Luo Renbo

    2012-01-01

    Based on comprehensive analysis of the impact of population aging to social and economic development, a comprehensive evaluation system including 18 indexes was constructed for evaluating regional pressure of population aging on social and economic development. Using statistics data of 31 regions in Chi- na from 2004 to 2008, the pressure of population aging on social and economic development, was comprehensively evaluated by using the factor analysis method. The spatial distribution of popu- lation aging in China was also analyzed. This study is to provide scientific basis for government to make strategies of coping with population aging according to regional pressure of population ag- ing on social and economic development in China.

  13. Analysis of Ageing Effect on Li-Polymer Batteries

    Directory of Open Access Journals (Sweden)

    Simone Barcellona

    2015-01-01

    Full Text Available Lithium-ion batteries are a key technology for current and future energy storage in mobile and stationary application. In particular, they play an important role in the electrification of mobility and therefore the battery lifetime prediction is a fundamental aspect for successful market introduction. Numerous studies developed ageing models capable of predicting battery life span. Most of the previous works compared the effect of the ageing factors to a battery’s cycle life. These cycles are identical, which is not the case for electric vehicles applications. Indeed, most of the available information is based on results from laboratory testing, under very controlled environments, and using ageing protocols, which may not correctly reflect the actual utilization. For this reason, it is important to link the effect of duty cycles with the ageing of the batteries. This paper proposes a simple method to investigate the effect of the duty cycle on the batteries lifetime through tests performed on different cells for different kinds of cycle. In this way, a generic complex cycle can be seen as a composition of elemental cycles by means of Rainflow procedures. Consequently, the ageing due to any cycle can be estimated starting from the knowledge of simpler cycles.

  14. Analysis of Ageing Effect on Li-Polymer Batteries.

    Science.gov (United States)

    Barcellona, Simone; Brenna, Morris; Foiadelli, Federica; Longo, Michela; Piegari, Luigi

    2015-01-01

    Lithium-ion batteries are a key technology for current and future energy storage in mobile and stationary application. In particular, they play an important role in the electrification of mobility and therefore the battery lifetime prediction is a fundamental aspect for successful market introduction. Numerous studies developed ageing models capable of predicting battery life span. Most of the previous works compared the effect of the ageing factors to a battery's cycle life. These cycles are identical, which is not the case for electric vehicles applications. Indeed, most of the available information is based on results from laboratory testing, under very controlled environments, and using ageing protocols, which may not correctly reflect the actual utilization. For this reason, it is important to link the effect of duty cycles with the ageing of the batteries. This paper proposes a simple method to investigate the effect of the duty cycle on the batteries lifetime through tests performed on different cells for different kinds of cycle. In this way, a generic complex cycle can be seen as a composition of elemental cycles by means of Rainflow procedures. Consequently, the ageing due to any cycle can be estimated starting from the knowledge of simpler cycles. PMID:26236775

  15. Experimental and Numerical Analysis of Electronics Heat Sink

    Directory of Open Access Journals (Sweden)

    Ahmad F. Ismail, Mirghani I. Ahmed, and Yousif A. Abakr

    2012-09-01

    Full Text Available Cooling of electronic components continues to attract many research and development activities towards achieving an effective way of cooling. Computational fluid dynamics (CFD tools may be considered as a cheap substitute for expensive experimental testing methods. In this work the cooling of a simulated electronic board was modeled using FLUENTTM CFD software, and experimental procedures were followed to validate the estimated results, and to understand the factors that would affect the software capability to predict the actual measured values. Results showed good agreement between the simulation and experimental results. The software was found to be capable to predict the exact values at the locations where the temperature values were similar to the board mean temperature. The maximum percentage error was found to be limited to 4.7%, and the capability of the software to estimate the exact measured values was found to be affected by the function of thermal wake generation. Keywords: CFD, Electronic cooling, Heat sink, Simulation

  16. CONCENTRATION OF CIRCULATING IMMUNE COMPLEXES IN EXPERIMENTAL GENERALIZED INFLAMMATORY PROCESS IN ANIMALS OF DIFFERENT AGE UNDER ACTION OF IMMUNOMODULATORS

    Directory of Open Access Journals (Sweden)

    Kovalenko T.I.

    2015-05-01

    Full Text Available Under physiological conditions a formation and a presence of the CEC in liquids is one of the manifestations of the immune response to receipt of antigens and an important factor, which provides immunity. Circulating immune complexes act as agents involved in the regulation of immune response and maintaining communication between the immune system and other regulatory systems of the body and direction to his defense. The intensity of the formation of the CEC may vary under the influence of infectious antigens and immune preparations. Material and methods. Material for the experiment were white male rats 3 months of age ("young" weighing 100 -140gr. (n = 40 and 22-month ("old" weighing 200 -240 g. (n = 40. And the first (n=10 and second (n=10 groups of rats served as controls. Third (n=15 and fourth (n=15 group of animals was injected intraperitoneal daily agar culture of Pseudomonas aeruginosa № 27835 ATCC (injected with 1.5 ml suspension of bacteria, which contained 109 CFU/ml. Fifth (n=15 and sixth (n=15 groups of animals were injected intraperitoneally daily agar culture of Escherichia coli number 25592, ATCC (injected with 1.5 ml of bacteria suspension which contain 109 CFU/ml. Control animals were taken from the experiment by decapitation 3rd day – n=20. Control and infected animals were taken from the experiment by decapitation at 3rd day - n=27, 5th day – n=27 and 7th day – n=26. In the second phase of the experiment Ia (n = 6 and IIa (n = 6 were the control group of rats following administration of the experimental composite preparation consisting amino acids, nucleotides, enzymes, vitamins (MF. In two age groups of animals with inflammation induced by E. coli suspension treated with MF 20 mсl 3- month rats (IIIa group n = 6 and 40 mсl 22-month rats (IVa group n = 6. Ib (n = 6 and IIb (n = 6 were the control group of rats after the injection of comparison, containing mannitol and natural antioxidant betakaroten (PO. In two age

  17. Experimental analysis of pressurised humidification tower for humid air gas turbine cycles. Part A: Experimental campaign

    Energy Technology Data Exchange (ETDEWEB)

    Pedemonte, A.A. [Thermochemical Power Group (TPG), Dipartimento di Macchine, Sistemi Energetici e Trasporti (DIMSET), Universita di Genova, 16145 Genova (Italy); Traverso, A. [Thermochemical Power Group (TPG), Dipartimento di Macchine, Sistemi Energetici e Trasporti (DIMSET), Universita di Genova, 16145 Genova (Italy)], E-mail: alberto.traverso@unige.it; Massardo, A.F. [Thermochemical Power Group (TPG), Dipartimento di Macchine, Sistemi Energetici e Trasporti (DIMSET), Universita di Genova, 16145 Genova (Italy)

    2008-10-15

    One of the most interesting methods of water introduction in a gas turbine circuit is represented by the humid air turbine cycle (HAT). In the HAT cycle, the humidification can be provided by a pressurised saturator (i.e. humidification tower or saturation tower), this solution being known to offer several attractive features. This part A is focused on an experimental study of a pressurised humidification tower, with structured packing inside. After a description of the test rig employed to carry out the measuring campaign, the results relating to the thermodynamic process are presented and discussed. The experimental campaign was carried out over 162 working points, covering a relatively wide range of possible operating conditions. Details about measured data are provided in the appendix. It is shown that the saturator's behaviour, in terms of air outlet humidity and temperature, is primarily driven by, in decreasing order of relevance, the inlet water temperature, the inlet water over inlet dry air mass flow ratio and the inlet air temperature. Finally, the exit relative humidity is shown to be consistently over 100%, which may be explained partially by measurement accuracy and droplet entrainment, and partially by the non-ideal behaviour of air-steam mixtures close to saturation.

  18. Inclusion of Aging in Rehabilitation Counseling Journals 2000-2012: A Content Analysis

    Science.gov (United States)

    Kettaneh, Amani A.; Kinyanjui, Benson; Slevin, John R.; Slevin, Barbara; Harley, Debra A.

    2015-01-01

    Purpose: To conduct a content analysis of the rehabilitation counseling literature to identify articles published on aging. Method: To determine the number of articles that were published on aging in rehabilitation counseling journals, a content analysis of articles from 2000 through 2012 was performed. For purposes of this review, only…

  19. Age, the psychological contract, and job attitudes : a meta-analysis

    NARCIS (Netherlands)

    Bal, P. Matthijs; de Lange, Annet H.; Jansen, Paul G. W.; van der Velde, Mandy E. G.

    2010-01-01

    Age, the psychological contract, and job attitudes: a meta-analysis P.M. Bal, A H. De Lange, P.G.W Jansen Er M.E G Van der Velde, Gedrag en Organisatie, volume 23, March 2010, nr 1, pp 44-72. The meta-analysis investigated the relations between age and psychological contracts It was expected that ag

  20. Estimation of age in forensic medicine using multivariate approach to image analysis

    DEFF Research Database (Denmark)

    Kucheryavskiy, Sergey V.; Belyaev, Ivan; Fominykh, Sergey

    2009-01-01

    A new method for victims' age estimation, based on the image processing and analysis of remains bones structure, is proposed. Digital images of lumbar vertebras cuts were used as a major information source. The age related properties were extracted from the images using classic texture analysis...

  1. A Bayesian Analysis of the Ages of Four Open Clusters

    CERN Document Server

    Jeffery, Elizabeth J; van Dyk, David A; Stenning, David C; Robinson, Elliot; Stein, Nathan; Jefferys, W H

    2016-01-01

    In this paper we apply a Bayesian technique to determine the best fit of stellar evolution models to find the main sequence turn off age and other cluster parameters of four intermediate-age open clusters: NGC 2360, NGC 2477, NGC 2660, and NGC 3960. Our algorithm utilizes a Markov chain Monte Carlo technique to fit these various parameters, objectively finding the best-fit isochrone for each cluster. The result is a high-precision isochrone fit. We compare these results with the those of traditional "by-eye" isochrone fitting methods. By applying this Bayesian technique to NGC 2360, NGC 2477, NGC 2660, and NGC 3960, we determine the ages of these clusters to be 1.35 +/- 0.05, 1.02 +/- 0.02, 1.64 +/- 0.04, and 0.860 +/- 0.04 Gyr, respectively. The results of this paper continue our effort to determine cluster ages to higher precision than that offered by these traditional methods of isochrone fitting.

  2. Relocation of the Aged: A Review and Theoretical Analysis

    Science.gov (United States)

    Schulz, Richard; Brenner, Gail

    1977-01-01

    Literature on relocation of the aged is examined and findings are presented within a framework of three types of moves--institution to institution, home to institution, and home to home--with each type having a voluntary and involuntary component. A theoretical model is proposed to explain contradictory results reported. (Author)

  3. Case-control analysis of paternal age and trisomic anomalies

    NARCIS (Netherlands)

    De Souza, E.; Morris, Joan K.

    2010-01-01

    Objectives To determine whether older paternal age increases the risk of fathering a pregnancy with Patau (trisomy 13), Edwards (trisomy 18), Klinefelter (XXY) or XYY syndrome. Design Case-control: cases with each of these syndromes were matched to four controls with Down syndrome from within the sa

  4. Experimental Analysis and Model Validation of an Opaque Ventilated Facade

    DEFF Research Database (Denmark)

    López, F. Peci; Jensen, Rasmus Lund; Heiselberg, Per;

    2012-01-01

    Natural ventilation is a convenient way of reducing energy consumption in buildings. In this study an experimental module of an opaque ventilated façade (OVF) was built and tested for assessing its potential of supplying free ventilation and air preheating for the building. A numerical model was ...

  5. MODEL METHODS FOR THE ANALYSIS OF MESOCOSM EXPERIMENTAL STUDIES

    NARCIS (Netherlands)

    BRINKMAN, AG; PHILIPPART, CJM; ZUUR, AF

    1995-01-01

    The response of experimental ecosystem dynamics to varying nutrient loads was studied by analysing oxygen time-series. Time-series had been continuously recorded, and the data were analysed on a daily basis using a computer model which describes basic oxygen processes. The resulting sets of producti

  6. Floor Heating with Displacement Ventilation: An Experimental and Numerical Analysis

    DEFF Research Database (Denmark)

    Causone, Francesco; Olesen, Bjarne W.; Corgnati, S.P.

    2010-01-01

    The effect of floor heating combined with displacement ventilation (DV) on thermal indoor environments and indoor air quality (IAQ) was studied by means of CFD. The numerical model was validated with experimental data. A typical office room was simulated, and one of the occupants was considered t...

  7. Experimental Disclosure and Its Moderators: A Meta-Analysis

    Science.gov (United States)

    Frattaroli, Joanne

    2006-01-01

    Disclosing information, thoughts, and feelings about personal and meaningful topics (experimental disclosure) is purported to have various health and psychological consequences (e.g., J.W. Pennebaker, 1993). Although the results of 2 small meta-analyses (P. G. Frisina, J. C. Borod, & S. J. Lepore, 2004; J. M. Smyth, 1998) suggest that experimental…

  8. Population ageing and fiscal sustainability in Finland: a stochastic analysis

    OpenAIRE

    Lassila, Jukka; Valkonen, Tarmo

    2008-01-01

    This study analyses the fiscal sustainability of the Finnish public sector using stochastic projections to describe uncertain future demographic trends and asset yields. While current tax rates are unlikely to yield sufficient tax revenue to finance public expenditure with an ageing population, if developments are as expected, the problem will not be very large. However, there is a small, but not negligible, probability that taxes will need to be raised dramatically, perhaps by over 5 percent...

  9. BUYING BEHAVIOR ANALYSIS IN A SIMULATED EXPERIMENTAL CONTEXT

    OpenAIRE

    Iván Echeverry Gómez; Marithza Sandoval Escobar

    2011-01-01

    The aim of this study was to identify the effects of the consumption scenario(Foxall, 2007) and the level of informational reinforcement (Foxall, 2005) on theprobability of buying behavior. The study involved 56 people between 18 to 20years of age selected through intentional sampling. We designed a web applicationthat emulated conditions of purchase in a virtual store. Functional analysiswas performed using a logit model of LR (logistic regression) to calculate individualand group effects of...

  10. Birefringence of cellotape: Jones representation and experimental analysis

    Energy Technology Data Exchange (ETDEWEB)

    Belendez, Augusto; Frances, Jorge; Neipp, Cristian [Departamento de Fisica, Ingenieria de Sistemas y Teoria de la Senal, Universidad de Alicante, Apartado 99, E-03080 Alicante (Spain); Fernandez, Elena [Departamento de Optica, FarmacologIa y Anatomia, Universidad de Alicante, Apartado 99, E-03080 Alicante (Spain)], E-mail: a.belendez@ua.es

    2010-05-15

    In this paper, we analyse a simple experiment to study the effects of polarized light. A simple optical system composed of a polarizer, a retarder (cellotape) and an analyser is used to study the effect on the polarization state of the light which impinges on the setup. The optical system is characterized by means of a Jones matrix, and a simple procedure based on Jones vectors is used to obtain an expression for the intensity after the light passes through the optical system. The light intensity is measured by a photodetector and the expression obtained theoretically is experimentally validated. By fitting the experimental intensity data, the value of the retardation introduced by the retarder can also be obtained.

  11. Experimental analysis of blast mitigation associated with water sheets

    Science.gov (United States)

    Zakrajsek, Andrew J.; Miklaszewski, Eric J.; Guildenbecher, Daniel R.; Son, Steven F.

    2012-03-01

    An explosion yielding a blast wave can cause catastrophic damage to a building and its personnel. This threat defines an immediate importance for understanding blast mitigation techniques via readily available materials. An unconfined mass of water in the form of a free flowing sheet has been experimentally tested and analyzed as a readily available mitigant. A single water sheet, with an approximate sheet thickness of 3 mm, was experimentally tested with an explosively driven shock tube at three different standoff distances. At the strongest shock strength considered, the water sheet decreased the peak overpressure of the blast wave by 80% and the impulse by 60%. Additionally, the peak overpressure transmitted through the water sheet was roughly constant regardless of standoff distance and explosive strength.

  12. FE analysis of tube forming process with experimental verification

    OpenAIRE

    Mandic, V.; Stefanovic, M.; M. Zivkovic; N. Grujovic; B. Misic

    2006-01-01

    Purpose: of this paper: The paper presents some results of extensive investigation of steel seam-welded tubesforming process, by applying combined treatment of material narrowing and expansion. The objective ofexecuted numerical FE and experimental investigations was to determine the optimal technology for productionof tubular product at simple tools and at the standard forming processing machines, without defects and withdemanded dimensional accuracy.Design/methodology/approach: Tube forming...

  13. Optimal Prizes in Dynamic Elimination Contests: An Experimental Analysis

    OpenAIRE

    Stracke, Rudi; Höchtl, Wolfgang; Kerschbamer, Rudolf; Sunde, Uwe

    2013-01-01

    This paper investigates the effects of different prize structures on the effort choices of participants in two-stage elimination contests. A format with a single prize is shown to maximize total effort over both stages, but induces low effort in stage 1 and high effort in stage 2. By contrast, a format that allocates the same total amount to multiple prizes in such a way that the predicted effort remains constant across stages yields lower total effort provision. Experimental evidence suggest...

  14. Experimental methods for the analysis of optimization algorithms

    CERN Document Server

    Bartz-Beielstein, Thomas; Paquete, Luis; Preuss, Mike

    2010-01-01

    In operations research and computer science it is common practice to evaluate the performance of optimization algorithms on the basis of computational results, and the experimental approach should follow accepted principles that guarantee the reliability and reproducibility of results. However, computational experiments differ from those in other sciences, and the last decade has seen considerable methodological research devoted to understanding the particular features of such experiments and assessing the related statistical methods. This book consists of methodological contributions on diffe

  15. Dynamics of a high speed impeller - Analysis and experimental verification

    Science.gov (United States)

    Straub, F. K.; Ngo, H.; Silverthorn, L. J.; Ruopsa, J. A.

    1993-04-01

    Centrifugal compressors are used on numerous aircraft as an efficient and lightweight source of air. The impeller is the key compressor component, both from an aerodynamic and structural dynamics point of view. The present paper investigates the structural dynamics of the blades of a particular impeller, using analytical and experimental methods. Correlation of results show good agreement. The analytical model is then used for design studies to improve the fatigue life of the impeller blades.

  16. Finite Element and Experimental Analysis of Function of Plastic Clips

    OpenAIRE

    Honarpardaz, Mohammad Mahdi

    2011-01-01

    The aim of this work is to investigate the function of plastic clips which are used to join different parts, during mounting and dismounting processes. The clips are made of POM and will be mounted on steel plates. The study is undertaken using experimental and numerical methods. In experiments, the mounting and dismounting forces are measured with respect to vertical displacement of the clips related to the plate. The numerical method is performed using structural implicit non-linear quasi-s...

  17. Experimental facility for analysis of biomass combustion characteristics

    Directory of Open Access Journals (Sweden)

    Miljković Biljana M.

    2015-01-01

    Full Text Available The objective of the present article is to present an experimental facility which was designed and built at the Faculty of Technical Sciences in order to study the combustion of different sorts of biomass and municipal solid waste. Despite its apparent simplicity, direct combustion is a complex process from a technological point of view. Conventional combustion equipment is not designed for burning agricultural residues. Devices for agricultural waste combustion are still in the development phase, which means that adequate design solution is presently not available at the world market. In order to construct a boiler and achieve optimal combustion conditions, it is necessary to develop a mathematical model for biomass combustion. Experimental facility can be used for the collection of data necessary for detailed modelling of real grate combustor of solid biomass fuels. Due to the complexity of the grate combustion process, its mathematical models and simulation software tools must be developed and verified using experimental data. This work highlights the properties required for the laboratory facility designed for the examination of biomass combustion and discusses design and operational issues.

  18. Humidification tower for humid air gas turbine cycles: Experimental analysis

    Energy Technology Data Exchange (ETDEWEB)

    Traverso, A. [DIMSET (TPG), University of Genoa, Via Montallegro 1, 16145 Genoa (Italy)

    2010-02-15

    In the HAT (humid air turbine) cycle, the humidification of compressed air can be provided by a pressurised saturator (i.e. humidification tower or saturation tower), this solution being known to offer several attractive features. This work is focused on an experimental study of a pressurised humidification tower, with structured packing. After a description of the test rig employed to carry out the measuring campaign, the results relating to the thermodynamic process are presented and discussed. The experimental campaign was carried out over 162 working points, covering a relatively wide range of possible operating conditions. It is shown that the saturator behaviour, in terms of air outlet humidity and temperature, is primarily driven by, in decreasing order of relevance, the inlet water temperature, the inlet water over inlet dry air mass flow ratio and the inlet air temperature. The exit relative humidity is consistently over 100%, which may be explained partially by measurement accuracy and droplet entrainment, and partially by the non-ideal behaviour of air-steam mixtures close to saturation. Experimental results have been successfully correlated using a set of new non-dimensional groups: such a correlation is able to capture the air outlet temperature with a standard deviation {sigma} = 2.8 K. (author)

  19. Experimental analysis of heat flow in simulated fuel elements

    International Nuclear Information System (INIS)

    Since the experimental point of view it has been developed so much thermic simulations of nuclear reactors fuel elements in the laboratory. It is treating to isolate the problem of heat transfer of the complexity of the radioactive materials handling. The simulations starting of electric warming of similar geometric bodies to the real fuel elements. In the Thermo fluids Laboratory of National Institute of Nuclear Research it has been carried out heat transfer experiments in simulated fuel elements using in a first step concentric cylinders, for later to pass to posterior step of direct warming. The purpose of this work is to determine the convective parameters in the refrigerating under the typical prevailing conditions in the experimental reactors. It has been planned to work with isolated bars and groups of bars in convection with water. These works will allow to stablish the infrastructure of laboratory where it can be simulated thermically fuel elements of diverse types of experimental reactors. And specially to observe the solid-fluid effects in vertical surfaces subjected to intense heat fluxes. (Author)

  20. Experimental analysis of the ventilated roof thermal performance; Analise experimental do desempenho termico de coberturas ventiladas

    Energy Technology Data Exchange (ETDEWEB)

    Cunha Neto, Jose Antonio Bellini da; Nicolau, Vicente de Paulo; Philippi, Paulo Cesar; Pereira, Fernando Oscar Ruttkay [Santa Catarina Univ., Florianopolis, SC (Brazil)

    1988-12-31

    Double ventilated roofs are being increasingly used in buildings for reducing the radiant solar load. Heat is transferred from the tiles by thermal convection with cooling breezes which flow in the spacing between the covers and this process will define the thermal efficiency of the roof. In this paper, the results of an experimental work are presented, regarding the thermal performance of ventilated roofs. The measuring process is complicated due to the following factors: i) high turbulence intensity of atmospheric flows, ii) high frequency temperature fluctuations of the cooling breezes, iii) need of high accuracy in temperature measurement, specially for predicting the temperature difference between the air flow and the internal cover. These factors contribute to a high dispersion in the values of the heat transfer coefficient with the air speed in the roof, and difficult the modelisation of the process. Nevertheless, taking the above difficulties in account, the results appear to be reliable and have been compared with a numerical model for simulating the thermal behaviour of the roof. (author) . 7 refs., 7 figs.

  1. Influencing factors analysis of spontaneous knee joint osteoarthritis among middle aged and old aged pople in Xi'an

    Institute of Scientific and Technical Information of China (English)

    WANG Wei; WANG Kun-zheng; DANG Xiao-qian; BAI Chuan-yi; WANG Chun-sheng; SHI ZHi-bin; MA Shu-qiang

    2007-01-01

    Objective:To explore the prevalence rate of knee joint osteoarthritis and its pathogenetic features among the middle-aged and old aged people in the urban and rural area of Xi'an. Methods: From May to October 2005, 1 538 Han nationality above 40 years in Xi'an were investigated according to stratified and cluster random sampling. The same questionnaire was delivered to subjects who had been given normotopia and lateral position radiographic examination in both knees. Excluded from etiological arthritis, some subjects with clinical symptoms and a radiographic grade (beyond Kellgren & Lawrence grade Ⅱ ) were finally diagnosed as spontaneous knee joint osteoarthritis. All analyses were performed with SPSS 13.0 and t test, U test. Single factor analysis and multiple logistic regression analysis were used to analyze dates. Results: The total prevalence of spontaneous knee joint osteoarthritis was 12. 1% with 2.5% and 2.1% for right and left knees, respectively. The prevalence of knee joint osteoarthritis in women was 2.5 times of that in men (17.2% vs 6.8%, P=0.000). the osteophyte prevalence in women was 2.3 times of that in men (26.5% vs 11.4%, P=0.000). The prevalence of knee joint osteoarthritis and osteophyte increased with the growth of age. So did the symptomatic knee, except for the age group of 56-60 years and 66-70 years. The prevalence of symptomatic knee joint for urban area was significantly higher than that for rural area (56. 3% vs 45.3%, P=0.003). In women, the prevalence of knee joint osteoarthritis increased significantly with the increasing of body mass index, which had not been observed in men. Female and obesity are the risk factors for osteoarthritis, but bean and its products and meat could prevent the osteoarthritis. Conclusion: Old age, female and obesity serve as risk factors for knee joint osteoarthritis.

  2. Transparent meta-analysis: does aging spare prospective memory with focal vs. non-focal cues?

    Directory of Open Access Journals (Sweden)

    Bob Uttl

    Full Text Available BACKGROUND: Prospective memory (ProM is the ability to become aware of a previously-formed plan at the right time and place. For over twenty years, researchers have been debating whether prospective memory declines with aging or whether it is spared by aging and, most recently, whether aging spares prospective memory with focal vs. non-focal cues. Two recent meta-analyses examining these claims did not include all relevant studies and ignored prevalent ceiling effects, age confounds, and did not distinguish between prospective memory subdomains (e.g., ProM proper, vigilance, habitual ProM (see Uttl, 2008, PLoS ONE. The present meta-analysis focuses on the following questions: Does prospective memory decline with aging? Does prospective memory with focal vs. non-focal cues decline with aging? Does the size of age-related declines with focal vs. non-focal cues vary across ProM subdomains? And are age-related declines in ProM smaller than age-related declines in retrospective memory? METHODS AND FINDINGS: A meta-analysis of event-cued ProM using data visualization and modeling, robust count methods, and conventional meta-analysis techniques revealed that first, the size of age-related declines in ProM with both focal and non-focal cues are large. Second, age-related declines in ProM with focal cues are larger in ProM proper and smaller in vigilance. Third, age-related declines in ProM proper with focal cues are as large as age-related declines in recall measures of retrospective memory. CONCLUSIONS: The results are consistent with Craik's (1983 proposal that age-related declines on ProM tasks are generally large, support the distinction between ProM proper vs. vigilance, and directly contradict widespread claims that ProM, with or without focal cues, is spared by aging.

  3. FE analysis of tube forming process with experimental verification

    Directory of Open Access Journals (Sweden)

    V. Mandic

    2006-08-01

    Full Text Available Purpose: of this paper: The paper presents some results of extensive investigation of steel seam-welded tubesforming process, by applying combined treatment of material narrowing and expansion. The objective ofexecuted numerical FE and experimental investigations was to determine the optimal technology for productionof tubular product at simple tools and at the standard forming processing machines, without defects and withdemanded dimensional accuracy.Design/methodology/approach: Tube forming was done in one phase, in tool with two shaping spherical parts,that enables the expansion of the specimen’s central zone and the filling of the die due to narrowing of thespecimen ends, when certain conditions are achieved and with appropriate combination of influential processparameters (outer diameter, height and tube’s wall thickness, as well as friction conditions. Series of physicaland numerical FE experiments was performed.Findings: Optimal dimensions of tubular product, with required process stability, were obtained this way. Also,results of experiments pointed out that the best process stability and die filling is achieved with specimenswhose surfaces had previously been chemically treated. Results of numerical FE simulations of process arequite verified by experiments.Practical implications: Obtained results have practical significance in solving similar processing problems. Italso enables to investigate and broaden the knowledge on stability of these kinds of processes, beyond the scopeof experimental investigations. Tubular product that is subjected to numerical-experimental investigation in thispaper is prepared by narrowing it at both ends thus excluding the possibility to apply holder inside the tube.Originality/value: Proposed method offers possibility for production of tubular products at simple formingmachines and tools, without complex and expensive hydroforming equipment.

  4. Experimental and theoretical analysis of Wankel engine performance

    Energy Technology Data Exchange (ETDEWEB)

    Danieli, G.A.; Keck, J.C.; Heywood, J.B.

    1978-01-01

    A model for predicting the performance and emissions characteristics of Wankel engines has been developed and tested. Each chamber is treated as an open thermodynamic system and the effects of turbulent flame propagation, quench layer formation, gas motion, heat transfer and seal leakage are included. The experimental tests were carried out on a Toyo Kogyo 12B engine under both motoring and firing conditions and values for the effective seal leakage area and turbulent heat transfer coefficient were deduced. The agreement between the predicted and measured performances was reasonable. Parametric studies of the effects of reductions in seal leakage and heat transfer were carried out and the results are presented.

  5. Knowledge-based data analysis comes of age

    OpenAIRE

    Michael F Ochs

    2009-01-01

    The emergence of high-throughput technologies for measuring biological systems has introduced problems for data interpretation that must be addressed for proper inference. First, analysis techniques need to be matched to the biological system, reflecting in their mathematical structure the underlying behavior being studied. When this is not done, mathematical techniques will generate answers, but the values and reliability estimates may not accurately reflect the biology. Second, analysis app...

  6. Is the repair of articular cartilage lesion by costal chondrocyte transplantation donor age-dependent? An experimental study in rabbits.

    Directory of Open Access Journals (Sweden)

    Janusz Popko

    2006-09-01

    Full Text Available The repair of chondral injuries is a very important problem and a subject of many experimental and clinical studies. Different techniques to induce articular cartilage repair are under investigation. In the present study, we have investigated whether the repair of articular cartilage folowing costal chondrocyte transplantation is donor age-dependent. Transplantation of costal chondrocytes from 4- and 24-week old donors, with artificially induced femoral cartilage lesion, was performed on fourteen 20-week-old New Zealand White male rabbits. In the control group, the lesion was left without chondrocyte transplantation. The evaluation of the cartilage repair was performed after 12 weeks of transplantation. We analyzed the macroscopic and histological appearance of the newly formed tissue. Immunohistochemistry was also performed using monoclonal antibodies against rabbit collagen type II. The newly formed tissue had a hyaline-like appearance in most of the lesions after chondrocyte transplantation. Positive immunohistochemical reaction for collagen II was also observed in both groups with transplanted chondrocytes. Cartilage from adult donors required longer isolation time and induced slightly poorer repair. However, hyaline-like cartilage was observed in most specimens from this group, in contrast to the control group, where fibrous connective tissue filled the lesions. Rabbit costal chondrocytes seem to be a potentially useful material for inducing articular cartilage repair and, even more important, they can also be derived from adult, sexually mature animals.

  7. Analysis of malaria parasite phenotypes using experimental genetic crosses of Plasmodium falciparum

    OpenAIRE

    Ranford-Cartwright, Lisa C; Mwangi, Jonathan M.

    2012-01-01

    We review the principles of linkage analysis of experimental genetic crosses and their application to Plasmodium falciparum. Three experimental genetic crosses have been performed using the human malaria parasite P. falciparum. Linkage analysis of the progeny of these crosses has been used to identify parasite genes important in phenotypes such as drug resistance, parasite growth and virulence, and transmission to mosquitoes. The construction and analysis of genetic maps has been used to char...

  8. Computer-assisted analysis of cervical vertebral bone age using cephalometric radiographs in Brazilian subjects

    Directory of Open Access Journals (Sweden)

    Maria de Paula Caldas

    2010-03-01

    Full Text Available The aims of this study were to develop a computerized program for objectively evaluating skeletal maturation on cephalometric radiographs, and to apply the new method to Brazilian subjects. The samples were taken from the patient files of Oral Radiological Clinics from the North, Northeast, Midwest and South regions of the country. A total of 717 subjects aged 7.0 to 15.9 years who had lateral cephalometric radiographs and hand-wrist radiographs were selected. A cervical vertebral computerized analysis was created in the Radiocef Studio 2 computer software for digital cephalometric analysis, and cervical vertebral bone age was calculated using the formulas developed by Caldas et al.17 (2007. Hand-wrist bone age was evaluated by the TW3 method. Analysis of variance (ANOVA and the Tukey test were used to compare cervical vertebral bone age, hand-wrist bone age and chronological age (P < 0.05. No significant difference was found between cervical vertebral bone age and chronological age in all regions studied. When analyzing bone age, it was possible to observe a statistically significant difference between cervical vertebral bone age and hand-wrist bone age for female and male subjects in the North and Northeast regions, as well as for male subjects in the Midwest region. No significant difference was observed between bone age and chronological age in all regions except for male subjects in the North and female subjects in the Northeast. Using cervical vertebral bone age, it might be possible to evaluate skeletal maturation in an objective manner using cephalometric radiographs.

  9. Experimental Analysis of Podded Propulsor on Naval Vessel

    Directory of Open Access Journals (Sweden)

    M.P. Abdul Ghani

    2014-03-01

    Full Text Available This paper describes the effect of pod propulsor attachment to the existing Naval Vessel hull form which was designed for conventional propulsor in aspects of resistance and motion characteristics. These investigations were carried out on a 3.0 m model by experimental works in the towing tank 120m x 4m x 2.5m at the Marine Technology Centre (MTC, Universiti Teknologi Malaysia (UTM. The basis ship chosen for this study is Sealift class type MPCSS (Multi Purpose Command Support Ship. In this study, the design for the new pod propulsor is based on a proven design and scaled down to suit this type of hullform accordingly. This paper describes the resistance comparison between bare and podded hulls in calm water as well in waves. The seakeeping test for hull with and without pod in regular waves at service speed of 16.8 knots were carried out at wavelength to model length ratio, Lw/Lm between 0.2 and 1.2. The outcomes from this experimental works on hull with and without pod were compared.

  10. Laser Brazing with Beam Scanning: Experimental and Simulative Analysis

    Science.gov (United States)

    Heitmanek, M.; Dobler, M.; Graudenz, M.; Perret, W.; Göbel, G.; Schmidt, M.; Beyer, E.

    Laser beam brazing with copper based filler wire is a widely established technology for joining zinc-coated steel plates in the body-shop. Successful applications are the divided tailgate or the zero-gap joint, which represents the joint between the side panel and the roof-top of the body-in-white. These joints are in direct view to the customer, and therefore have to fulfil highest optical quality requirements. For this reason a stable and efficient laser brazing process is essential. In this paper the current results on quality improvement due to one dimensional laser beam deflections in feed direction are presented. Additionally to the experimental results a transient three-dimensional simulation model for the laser beam brazing process is taken into account. With this model the influence of scanning parameters on filler wire temperature and melt pool characteristics is analyzed. The theoretical predictions are in good accordance with the experimental results. They show that the beam scanning approach is a very promising method to increase process stability and seam quality.

  11. A retrospective mathematical analysis of controlled release design and experimentation.

    Science.gov (United States)

    Rothstein, Sam N; Kay, Jennifer E; Schopfer, Francisco J; Freeman, Bruce A; Little, Steven R

    2012-11-01

    The development and performance evaluation of new biodegradable polymer controlled release formulations relies on successful interpretation and evaluation of in vitro release data. However, depending upon the extent of empirical characterization, release data may be open to more than one qualitative interpretation. In this work, a predictive model for release from degradable polymer matrices was applied to a number of published release data in order to extend the characterization of release behavior. Where possible, the model was also used to interpolate and extrapolate upon collected released data to clarify the overall duration of release and also kinetics of release between widely spaced data points. In each case examined, mathematical predictions of release coincide well with experimental results, offering a more definitive description of each formulation's performance than was previously available. This information may prove particularly helpful in the design of future studies, such as when calculating proper dosing levels or determining experimental end points in order to more comprehensively evaluate a controlled release system's performance.

  12. Decreased pain sensitivity among people with schizophrenia: a meta-analysis of experimental pain induction studies.

    Science.gov (United States)

    Stubbs, Brendon; Thompson, Trevor; Acaster, Sarah; Vancampfort, Davy; Gaughran, Fiona; Correll, Christoph U

    2015-11-01

    Patients with schizophrenia report reduced pain sensitivity in clinical studies, but experimental studies are required to establish pain sensitivity as a potential endophenotype. We conducted a systematic review of electronic databases from database inception until April 15, 2015, including experimental studies investigating pain among patients with schizophrenia spectrum disorder vs healthy controls. A random-effect meta-analysis yielding Hedges' g ±95% confidence intervals (CIs) as the effect size (ES) measure was conducted. Primary outcome was a pooled composite of pain threshold and pain tolerance; secondary outcomes included these parameters individually, plus sensory threshold, physiological pain response, and pain intensity or unpleasantness. Across 17 studies, patients with schizophrenia spectrum disorder (n = 387; age, 30.7 ± 6.9 years; females, 31.9%; illness duration, 7.0 ± 5.7 years) were compared with controls (n = 483; age, 29.5 ± 7.4 years; females, 31.0%). Patients had elevated pain threshold/pain tolerance vs controls (ES = 0.583; 95% CI, 0.212-0.954; P = 0.002; studies = 15). Results were similar in antipsychotic-free individuals (ES = 0.599; 95% CI, 0.291-0.907; P pain tolerance (ES = 0.566; 95% CI, 0.235-0.897; P = 0.0001; studies = 6), sensory threshold (ES = 1.16; 95% CI, 0.505-1.727; P pain threshold (ES = 0.696; 95% CI, 0.407-0.986; P pain intensity/unpleasantness ratings (ES = 0.547; 95% CI, 0.146-0.949; P = 0.008). Findings were similarly significant in antipsychotic-free patients with schizophrenia (analysable parameters = 4) and antipsychotic-treated individuals (analysable parameters = 2). Finally, greater psychiatric symptoms moderated increased pain threshold, and younger patient age moderated increased pain tolerance. Decreased pain sensitivity seems to be an endophenotype of schizophrenia spectrum disorders. How this alteration links to other dimensions of schizophrenia and physical comorbidity-related help-seeking behaviour

  13. Experimental transport analysis code system in JT-60

    International Nuclear Information System (INIS)

    Transport analysis codes have been developed in order to study confinement properties related to particle and energy balance in ohmically and neutral beam heated plasmas of JT-60. The analysis procedure is divided into three steps as follows: 1) LOOK ; The shape of the plasma boundary is identified with a fast boundary identification code of FBI by using magnetic data, and flux surfaces are calculated with a MHD equilibrium code of SELENE. The diagnostic data are mapped to flux surfaces for neutral beam heating calculation and/or for radial transport analysis. 2) OFMC ; On the basis of transformed data, an orbit following Monte Carlo code of OFMC calculates both profiles of power deposition and particle source of neutral beam injected into a plasma. 3) SCOOP ; In the last stage, a one dimensional transport code of SCOOP solves particle and energy balance for electron and ion, in order to evaluate transport coefficients as well as global parameters such as energy confinement time and the stored energy. The analysis results are provided to a data bank of DARTS that is used to find an overview of important consideration on confinement with a regression analysis code of RAC. (author)

  14. Experimental burn plot trial in the Kruger National Park: history, experimental design and suggestions for data analysis

    Directory of Open Access Journals (Sweden)

    R. Biggs

    2003-12-01

    Full Text Available The experimental burn plot (EBP trial initiated in 1954 is one of few ongoing long-termfire ecology research projects in Africa. The trial aims to assess the impacts of differentfire regimes in the Kruger National Park. Recent studies on the EBPs have raised questions as to the experimental design of the trial, and the appropriate model specificationwhen analysing data. Archival documentation reveals that the original design was modified on several occasions, related to changes in the park's fire policy. These modifications include the addition of extra plots, subdivision of plots and changes in treatmentsover time, and have resulted in a design which is only partially randomised. The representativity of the trial plots has been questioned on account of their relatively small size,the concentration of herbivores on especially the frequently burnt plots, and soil variation between plots. It is suggested that these factors be included as covariates inexplanatory models or that certain plots be excluded from data analysis based on resultsof independent studies of these factors. Suggestions are provided for the specificationof the experimental design when analysing data using Analysis of Variance. It is concluded that there is no practical alternative to treating the trial as a fully randomisedcomplete block design.

  15. Scanning electron microscopy analysis of experimental bone hacking trauma.

    Science.gov (United States)

    Alunni-Perret, Veronique; Muller-Bolla, Michèle; Laugier, Jean-Pierre; Lupi-Pégurier, Laurence; Bertrand, Marie-France; Staccini, Pascal; Bolla, Marc; Quatrehomme, Gérald

    2005-07-01

    The authors report on their macro- and microscopy study of bone lesions made by a sharp force instrument (a single blade knife), and a sharp-blunt instrument classified as a chopping weapon (a hatchet). The aim of this work was to attempt to identify the instrument by analyzing the general class characteristics of the cuts. Each weapon was used on human bones. The results indicate that macroscopic analysis is more problematic. The microscopic analysis assessed that characteristics examined were effective in distinguishing sharp from sharp-blunt injury to the bone. The microscope facilitates analysis unachievable with macroscopic methods, some three-dimensional characteristics not visible to the naked eye being clearly defined with its use. Emphasis has been placed on the value of SEM as an anthropologist's tool in bone lesion injuries.

  16. BUYING BEHAVIOR ANALYSIS IN A SIMULATED EXPERIMENTAL CONTEXT

    Directory of Open Access Journals (Sweden)

    Iván Echeverry Gómez

    2011-12-01

    Full Text Available The aim of this study was to identify the effects of the consumption scenario(Foxall, 2007 and the level of informational reinforcement (Foxall, 2005 on theprobability of buying behavior. The study involved 56 people between 18 to 20years of age selected through intentional sampling. We designed a web applicationthat emulated conditions of purchase in a virtual store. Functional analysiswas performed using a logit model of LR (logistic regression to calculate individualand group effects of independient variables. Results indicate that there aresignificant differences in predictions performed with bivariate and multivariatelogit models of the effects of consumption scenario and informational reinforcementon the probability of buying behavior. These effects can be interpreted in thecontext of an operant perspective of symbolic behavior.

  17. Listener estimations of talker age: A meta-analysis of the literature.

    Science.gov (United States)

    Hunter, Eric J; Ferguson, Sarah Hargus; Newman, Catherine Anne

    2016-10-01

    Numerous studies, most of them cross-sectional studies using one sample per talker, have demonstrated that listeners make relatively accurate age judgments from hearing talkers' voices. The current study analyzed the results of several such direct age estimation studies to characterize better the perception of talker age over a larger number of individuals. A review of the direct age estimation literature was performed. Data sets from seven papers were reconstituted, and an analysis of the combined data (meta-analysis) including 530 data points was conducted. The reconstituted and combined data included talkers aged 10-90. Listeners appeared to overestimate age when talkers were younger and to underestimate it when talkers were older. PMID:26079468

  18. Experimental work and analysis of confined urban spaces

    Energy Technology Data Exchange (ETDEWEB)

    Coronel, J.F.; Alvarez, S. [Seville Univ., Thermal Engineering and Fluid Mechanics Dept., Seville (Spain)

    2001-07-01

    One of the objectives in the urban layout of some neighbourhoods in southern European cities was the improvement of the extreme conditions, which take place during the summer. These improvements are applicable for both private space (buildings, houses, private atrium, etc.) and public spaces (streets, open courtyards, squares, etc.), that are so important to the typical lifestyle in these latitudes. Confining and reducing dimensions of the streets is very important in the final thermal behaviour of these spaces. Some typical urban configurations reduce solar radiation (direct and diffuse) over these areas and modify the air flow patterns. The Santa Cruz district in Seville is included in this kind of space. Experimental work and simulations have been performed. Coupling the results from both studies, thermal behaviour of these spaces can be understood, and the so-called 'Oasis effect' present during the hottest hours of the day, can be explained. (Author)

  19. Experimental analysis of green roof substrate detention characteristics.

    Science.gov (United States)

    Yio, Marcus H N; Stovin, Virginia; Werdin, Jörg; Vesuviano, Gianni

    2013-01-01

    Green roofs may make an important contribution to urban stormwater management. Rainfall-runoff models are required to evaluate green roof responses to specific rainfall inputs. The roof's hydrological response is a function of its configuration, with the substrate - or growing media - providing both retention and detention of rainfall. The objective of the research described here is to quantify the detention effects due to green roof substrates, and to propose a suitable hydrological modelling approach. Laboratory results from experimental detention tests on green roof substrates are presented. It is shown that detention increases with substrate depth and as a result of increasing substrate organic content. Model structures based on reservoir routing are evaluated, and it is found that a one-parameter reservoir routing model coupled with a parameter that describes the delay to start of runoff best fits the observed data. Preliminary findings support the hypothesis that the reservoir routing parameter values can be defined from the substrate's physical characteristics.

  20. Experimental analysis of green roof substrate detention characteristics.

    Science.gov (United States)

    Yio, Marcus H N; Stovin, Virginia; Werdin, Jörg; Vesuviano, Gianni

    2013-01-01

    Green roofs may make an important contribution to urban stormwater management. Rainfall-runoff models are required to evaluate green roof responses to specific rainfall inputs. The roof's hydrological response is a function of its configuration, with the substrate - or growing media - providing both retention and detention of rainfall. The objective of the research described here is to quantify the detention effects due to green roof substrates, and to propose a suitable hydrological modelling approach. Laboratory results from experimental detention tests on green roof substrates are presented. It is shown that detention increases with substrate depth and as a result of increasing substrate organic content. Model structures based on reservoir routing are evaluated, and it is found that a one-parameter reservoir routing model coupled with a parameter that describes the delay to start of runoff best fits the observed data. Preliminary findings support the hypothesis that the reservoir routing parameter values can be defined from the substrate's physical characteristics. PMID:24135095

  1. Theoretical and experimental analysis of an optical driven servo system

    Science.gov (United States)

    Lu, F.; Wang, X. J.; Huang, J. H.; Liu, Y. F.

    2016-09-01

    An optical driven servo system model based on single-type PLZT ceramic is proposed in this paper. The control equation of the proposed servo system is derived based on the mathematical model of PLZT with coupled multi-physics fields. The parameters of photodeformation of the PLZT actuator during both the illumination phase and light off phase are identified through the static experiment. Then displacement response of optical driven servo system is numerically simulated based on the control equation presented in this paper. After that, the closed-loop control experiment of optical driven servo system based on PLZT single-type ceramic with a simple on-off method is carried out. The experimental results show that the optical driven servo system with simple on-off method can achieve the target displacement by applying UV light to the PLZT actuator. Furthermore, an improved on-off control strategy is proposed to decrease the undesirable fluctuation around the target displacement.

  2. Experimental Analysis of Pressure Fluctuations behind a Bottom Aerator

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Experimental observations show that the random process of two-phase flow beh ind an aerator is an ergodic process and its amplitude distribution is similar t o a normal distribution. The maximum pressure fluctuation is at the re-attachme n t point where the jet-trajectory flow over the aerator re-attaches to bottom o f the channel, and its amplitude is 2-3 times larger than when there is no aerato r. There is a dominant frequency of 1.24 Hz in the model, but the coherence in th e frequency domain is not obvious for other frequencies beside the dominant frequ ency. There is a large vortex at the re-attachment point behind the aerator but correlation among the measurement points is not obvious in the time domain.

  3. Experimental and Numerical Analysis of Structural Acousticcontrol Interior Noise Reduction

    Science.gov (United States)

    Mei, Chuh; Bevan, Jeffrey S.

    1999-01-01

    The research results contained in this technical report were performed under the NASA grant entitled "Experimental and Numerical Structural Acoustic Control for Interior Noise Reduction". The report is based essentially on partial progress of the Ph.D. dissertation prepared by Jeffrey S. Bevan under direct guidance of Dr. Chuh Mei. The document presents a finite element formulation and control of sound radiated from cylindrical panels embedded with piezoceramic actuators. The extended MIN6 shallow shell element is fully electrical-structural coupled. A piezoelectric modal actuator participation (PMAP) is defined which indicates the actuator performance to each of the offending modes. Genetic algorithm is also employed to validate the sensor and actuator locations determined by the PMAP criteria. The work was conducted at the Department of Aerospace Engineering, Old Dominion University. Mr. Travis L. Turner, Structural Acoustics Branch, NASA Langley Research Center is the technical monitor.

  4. Experimental vibration level analysis of a Francis turbine

    Science.gov (United States)

    Bucur, D. M.; Dunca, G.; Cǎlinoiu, C.

    2012-11-01

    In this study the vibration level of a Francis turbine is investigated by experimental work in site. Measurements are carried out for different power output values, in order to highlight the influence of the operation regimes on the turbine behavior. The study focuses on the turbine shaft to identify the mechanical vibration sources and on the draft tube in order to identify the hydraulic vibration sources. Analyzing the vibration results, recommendations regarding the operation of the turbine, at partial load close to minimum values, in the middle of the operating domain or close to maximum values of electric power, can be made in order to keep relatively low levels of vibration. Finally, conclusions are drawn in order to present the real sources of the vibrations.

  5. Experimental Analysis of Aerodynamic Aspects of Sport Utility Vehicle

    Directory of Open Access Journals (Sweden)

    DINESH Y DHANDE

    2013-07-01

    Full Text Available In an era fuel efficiency has become topic of discussion not only among the scholar researchers but also common men. As rapid and continuous increase in prizes of fuels consumers are going for most fuel efficient vehicles. By aerodynamic styling of vehicle one can not only improve the fuel efficiency but also ensure better stability and good handling characteristics of vehicles at higher speed especially on highways. The paper describes assessment of drag force (Fd and drag coefficient (Cd by conventional wind tunnel method. Theexperimental calculations were performed on subsonic wind tunnel having test section of 100cm x 30cm x 30 cm. Exact replica of model of sports utility vehicle (suv on reduced scale 1:32 is used to for experimentation to calculate Fd and Cd.

  6. Numerical and experimental analysis of a solid desiccant wheel

    Directory of Open Access Journals (Sweden)

    Koronaki Irene P.

    2016-01-01

    Full Text Available The rotary desiccant dehumidifier is an important component which can be used in air conditioning systems in order to reduce the electrical energy consumption and introduce renewable energy sources. In this study a one dimensional gas side resistance model is presented for predicting the performance of the desiccant wheel. Measurements from two real sorption wheels are used in order to validate the model. One wheel uses silica gel as desiccant material and the other lithium chloride. The simulation results are in good agreement with the experimental data. The model is used to compare the counter flow with the co-current wheel arrangements and to explain why the counter flow one is more efficient for air dehumidification.

  7. Experimental damage analysis of steels after exploitation loading

    Directory of Open Access Journals (Sweden)

    B. Augustyniak

    2010-06-01

    Full Text Available Development of creep damage at elevated temperatures and structural degradation due to plastic deformation at room temperature were assessed using destructive and non-destructive methods in steels commonly applied in power plants (40HNMA, 13HMF and P91. As destructive methods the standard tension tests were carried out after every kind of prestraining. Subsequently, an evolution of the selected tension parameters was taken into account for damage identification. In order to assess a damage development during the creep and plastic deformation the tests for the steels were interrupted for a range of the selected strain magnitudes. The ultrasonic and magnetic techniques were used as the non-destructive methods for damage evaluation. The experimental programme also contained microscopic observations.

  8. Mass spectrometry analysis of hepcidin peptides in experimental mouse models.

    Directory of Open Access Journals (Sweden)

    Harold Tjalsma

    Full Text Available The mouse is a valuable model for unravelling the role of hepcidin in iron homeostasis, however, such studies still report hepcidin mRNA levels as a surrogate marker for bioactive hepcidin in its pivotal function to block ferroportin-mediated iron transport. Here, we aimed to assess bioactive mouse Hepcidin-1 (Hep-1 and its paralogue Hepcidin-2 (Hep-2 at the peptide level. To this purpose, Fourier transform ion cyclotron resonance (FTICR and tandem-MS was used for hepcidin identification, after which a time-of-flight (TOF MS-based methodology was exploited to routinely determine Hep-1 and -2 levels in mouse serum and urine. This method was biologically validated by hepcidin assessment in: i 3 mouse strains (C57Bl/6; DBA/2 and BABL/c upon stimulation with intravenous iron and LPS, ii homozygous Hfe knock out, homozygous transferrin receptor 2 (Y245X mutated mice and double affected mice, and iii mice treated with a sublethal hepatotoxic dose of paracetamol. The results showed that detection of Hep-1 was restricted to serum, whereas Hep-2 and its presumed isoforms were predominantly present in urine. Elevations in serum Hep-1 and urine Hep-2 upon intravenous iron or LPS were only moderate and varied considerably between mouse strains. Serum Hep-1 was decreased in all three hemochromatosis models, being lowest in the double affected mice. Serum Hep-1 levels correlated with liver hepcidin-1 gene expression, while acute liver damage by paracetamol depleted Hep-1 from serum. Furthermore, serum Hep-1 appeared to be an excellent indicator of splenic iron accumulation. In conclusion, Hep-1 and Hep-2 peptide responses in experimental mouse agree with the known biology of hepcidin mRNA regulators, and their measurement can now be implemented in experimental mouse models to provide novel insights in post-transcriptional regulation, hepcidin function, and kinetics.

  9. The Analysis of the Age Structure of Regional Fixed Capital in the Agriculture

    Directory of Open Access Journals (Sweden)

    P. Mazouch

    2016-06-01

    Full Text Available The paper deals with an estimate and analysis of the value of regional net fixed capital stock and the age structure of machinery and equipment in Czech agriculture. In order to perform such analysis, the official model of perpetual inventory method is transformed into the Markov chain model and applied on regional data separately. Regional net fixed capital stock is presented for the period of 2008-2013. The development of the average age of machinery and equipment comprises a potential indicator of the modernisation process in the industry. The analysis of the age structure is based on the structure heterogeneity indicator. For these purposes, the real age structure in each Czech region is compared with the theoretical stable and stationary structure. Currently, the most heterogeneous age structure of machinery and equipment occurs in Prague and the Karlovy Vary region.

  10. Age validation of great hammerhead shark (Sphyrna mokarran), determined by bomb radiocarbon analysis

    OpenAIRE

    Passerotti, Michelle S.; John K. Carlson; Piercy, Andrew N.; Campana, Steven E.

    2010-01-01

    Preliminary validation of annual growth band deposition in vertebrae of great hammerhead shark (Sphyrna mokarran) was conducted by using bomb radiocarbon analysis. Adult specimens (n=2) were collected and thin sections of vertebral centra were removed for visual aging and use in radiocarbon assays. Vertebral band counts were used to estimate age, and year of formation was assigned to each growth band by subtracting estimated age from the year of capture. A total of 10 samples were extra...

  11. Age-structured mark-recapture analysis: A virtual-population-analysis-based model for analyzing age-structured capture-recapture data

    Science.gov (United States)

    Coggins, L.G., Jr.; Pine, William E., III; Walters, C.J.; Martell, S.J.D.

    2006-01-01

    We present a new model to estimate capture probabilities, survival, abundance, and recruitment using traditional Jolly-Seber capture-recapture methods within a standard fisheries virtual population analysis framework. This approach compares the numbers of marked and unmarked fish at age captured in each year of sampling with predictions based on estimated vulnerabilities and abundance in a likelihood function. Recruitment to the earliest age at which fish can be tagged is estimated by using a virtual population analysis method to back-calculate the expected numbers of unmarked fish at risk of capture. By using information from both marked and unmarked animals in a standard fisheries age structure framework, this approach is well suited to the sparse data situations common in long-term capture-recapture programs with variable sampling effort. ?? Copyright by the American Fisheries Society 2006.

  12. Age and work-related motives: Results of a meta-analysis

    NARCIS (Netherlands)

    Kooij, D.T.A.M.; Lange, A.H. de; Jansen, P.G.W.; Kanfer, R.; Dikkers, J.S.E.

    2011-01-01

    An updated literature review was conducted and a meta-analysis was performed to investigate the relationship between age and work-related motives. Building on theorizing in life span psychology, we hypothesized the existence of age-related differences in work-related motives. Specifically, we propos

  13. Age and work-related motives : Results of a meta-analysis

    NARCIS (Netherlands)

    Kooij, Dorien T. A. M.; De Lange, Annet H.; Jansen, Paul G. W.; Kanfer, Ruth; Dikkers, Josje S. E.

    2011-01-01

    An updated literature review was conducted and a meta-analysis was performed to investigate the relationship between age and work-related motives. Building on theorizing in life span psychology, we hypothesized the existence of age-related differences in work-related motives. Specifically, we propos

  14. Full scale experimental analysis of wind direction changes (EOD)

    DEFF Research Database (Denmark)

    Hansen, Kurt Schaldemose

    2007-01-01

    A coherent wind speed and wind direction change (ECD) load case is defined in the wind turbine standard. This load case is an essential extreme load case that e.g. may be design driving for flap defection of active stall controlled wind turbines. The present analysis identifies statistically...... wind direction gust amplitudes associated with the investigated European sites are low compared to the recommended IEC- values. However, these values, as function of the mean wind speed, are difficult to validate thoroughly due to the limited number of fully correlated measurements....... the magnitudes of a joint gust event defined by a simultaneously wind speed- and direction change in order to obtain an indication of the validity of the magnitudes specified in the IEC code. The analysis relates to pre-specified recurrence periods and is based on full-scale wind field measurements. The wind...

  15. Theory and application of experimental model analysis in earthquake engineering

    Science.gov (United States)

    Moncarz, P. D.

    The feasibility and limitations of small-scale model studies in earthquake engineering research and practice is considered with emphasis on dynamic modeling theory, a study of the mechanical properties of model materials, the development of suitable model construction techniques and an evaluation of the accuracy of prototype response prediction through model case studies on components and simple steel and reinforced concrete structures. It is demonstrated that model analysis can be used in many cases to obtain quantitative information on the seismic behavior of complex structures which cannot be analyzed confidently by conventional techniques. Methodologies for model testing and response evaluation are developed in the project and applications of model analysis in seismic response studies on various types of civil engineering structures (buildings, bridges, dams, etc.) are evaluated.

  16. Experimental and computational analysis of composite ankle-foot orthosis

    OpenAIRE

    Dequan Zou, DSc; Tao He, MS; Michael Dailey, MBA, CO; Kirk E. Smith, BS; Matthew J. Silva, PhD; David R. Sinacore, PhD, PT; Michael J. Mueller, PhD, PT; Mary K. Hastings, DPT, MSCI

    2015-01-01

    Carbon fiber (CF) ankle-foot orthoses (AFOs) can improve gait by increasing ankle plantar-flexor power and improving plantar-flexor ankle joint moment and energy efficiency compared with posterior leaf spring AFOs made of thermoplastic. However, fabricating a CF AFO to optimize the performance of the individual user may require multiple AFOs and expensive fabrication costs. Finite element analysis (FEA) models were developed to predict the mechanical behavior of AFOs in this study. Three AFOs...

  17. Sensitivity analysis of the age-structured malaria transmission model

    Science.gov (United States)

    Addawe, Joel M.; Lope, Jose Ernie C.

    2012-09-01

    We propose an age-structured malaria transmission model and perform sensitivity analyses to determine the relative importance of model parameters to disease transmission. We subdivide the human population into two: preschool humans (below 5 years) and the rest of the human population (above 5 years). We then consider two sets of baseline parameters, one for areas of high transmission and the other for areas of low transmission. We compute the sensitivity indices of the reproductive number and the endemic equilibrium point with respect to the two sets of baseline parameters. Our simulations reveal that in areas of either high or low transmission, the reproductive number is most sensitive to the number of bites by a female mosquito on the rest of the human population. For areas of low transmission, we find that the equilibrium proportion of infectious pre-school humans is most sensitive to the number of bites by a female mosquito. For the rest of the human population it is most sensitive to the rate of acquiring temporary immunity. In areas of high transmission, the equilibrium proportion of infectious pre-school humans and the rest of the human population are both most sensitive to the birth rate of humans. This suggests that strategies that target the mosquito biting rate on pre-school humans and those that shortens the time in acquiring immunity can be successful in preventing the spread of malaria.

  18. Recency, repeatability, and reinforcer retrenchment: an experimental analysis of resurgence.

    Science.gov (United States)

    Lieving, Gregory A; Lattal, Kennon A

    2003-09-01

    Four experiments were conducted with pigeons to assess the experimental conditions necessary for the occurrence of resurgence. The general procedure consisted of the following conditions: Condition 1--reinforcement of key pecking; Condition 2--reinforcement of treadle pressing and concurrent extinction of key pecking; and Condition 3--the resurgence condition wherein resurgence was defined as the recovery of key pecking. In Experiments 1 and 2, the resurgence condition was conventional extinction. The effect of recency on resurgence magnitude was examined in Experiment 1 by manipulating the number of sessions of Condition 2, above. Resurgence was not a function of recency with the parameters used. Repeating the three conditions revealed resurgence to be a repeatable effect in Experiment 2. In Experiment 3, a variable-time schedule was in effect for the resurgence condition. Resurgence was not produced by response-independent food delivery. In Experiment 4, the resurgence condition was a variable-interval schedule for treadle pressing that arranged a lower reinforcement rate than in Condition 2 (92% reduction in reinforcers per minute). Resurgence was lower in magnitude relative to conventional extinction, although resurgence was obtained with 2 out of 3 pigeons. The results are discussed in terms of the variables controlling resurgence and the relations between behavioral history, resurgence, and other forms of response recovery.

  19. Containment steam blowdown analysis: experimental and numerical comparisons

    International Nuclear Information System (INIS)

    This paper compares the numerical simulation with the experimental data of a steam blowdown event in a light water reactor containment building. A three step approach was used to analyze the steam jet behavior. First, the temperature and pressure data of a stem blowdown event was measured at the Purdue University Multi-Dimensional Integrated Test Assembly (PUMA), a scaled model of the General Electric Simplified Boiling Water Reactor. Second, a 1-Dimensional, system level RELAP5/Mod3.2 model of the steam blowdown event was created and the results used to set the initial conditions for the PUMA blowdown experiments. Finally, 2-Dimensional and 3-Dimensional CFD models of the discharged steam jets were computed using PHOENICS, a commercially available CFD package. It was found that RELAP5 is reasonably capable in predicting the general temperature and pressure trends in the RPV. However, due to modeling compromises and the code's built-in capabilities, RELAP5 1-Dimensional predictions of containment temperature and pressure did not compare well with measured data. On the other hand, with minor modifications to the k-ε turbulence model, the 2-Dimensional and 3-Dimensional PHOENICS CFD solutions compared extremely well with the measured data. (author)

  20. Experimental Thermal Analysis of Diesel Engine Piston and Cylinder Wall

    Directory of Open Access Journals (Sweden)

    Subodh Kumar Sharma

    2015-01-01

    Full Text Available Knowledge of piston and cylinder wall temperature is necessary to estimate the thermal stresses at different points; this gives an idea to the designer to take care of weaker cross section area. Along with that, this temperature also allows the calculation of heat losses through piston and cylinder wall. The proposed methodology has been successfully applied to a water-cooled four-stroke direct-injection diesel engine and it allows the estimation of the piston and cylinder wall temperature. The methodology described here combines numerical simulations based on FEM models and experimental procedures based on the use of thermocouples. Purposes of this investigation are to measure the distortion in the piston, temperature, and radial thermal stresses after thermal loading. To check the validity of the heat transfer model, measure the temperature through direct measurement using thermocouple wire at several points on the piston and cylinder wall. In order to prevent thermocouple wire entanglement, a suitable pathway was designed. Appropriate averaged thermal boundary conditions such as heat transfer coefficients were set on different surfaces for FE model. The study includes the effects of the thermal conductivity of the material of piston, piston rings, and combustion chamber wall. Results show variation of temperature, stresses, and deformation at various points on the piston.

  1. Mineral analysis in experimental corneal scars. An EDAX study

    Energy Technology Data Exchange (ETDEWEB)

    Bonafonte, S.; Fernandez del Cotero, J.N.; Aguirre Vila-Coro, A.

    1988-01-01

    Central penetrating excisional wounds were made in the corneas of 12 rabbits and 10 trout. The scar tissue and the surrounding cornea were compared using a new method for assessing inorganic elements in the cornea: the scanning electron microscopy and energy dispersive analysis of x-ray (EDAX). Semiquantitative determination of inorganic elements within the range of atomic numbers 9-93 in the periodic system was performed, comparing the relative concentration of those elements in the scar tissue to the surrounding cornea. Results showed that calcium was the only element higher in the healing wound than in the surrounding cornea.

  2. Experimental analysis of the levees safety based on geophysical monitoring

    Science.gov (United States)

    Rizzo, Enzo; Valeria, Giampaolo; Mario, Votta; Lapenna, Vincenzo; Moramarco, Tommaso; Aricò, Costanza; Camici, S.; Morbidelli, Renato; Sinagra, M.; Tucciarelli, T.

    2010-05-01

    Several flood events brought river levees into the focus of attention for some disasters due to their collapse. This phenomena is quite complex to investigate, because of different factors that can affect the stability of levees, among them the non uniformity of material properties, which influencing the permeability of the embankment, might induce high percolation velocity of flux thus triggering the unstability. Thus, to apply a fast and integrate investigation methods with a non-destructive characteristics should have a large interest, if they are able to furnish ready and usable information necessary to hydrogeological models. In order to achieve this goal, the University of Perugia (Department of Civil and Environmental Engineering) and the National Research Council (IRPI and IMAA research institutes) developed a collaborating project on the study of the internal structure of the river embankment by carrying out experiments in laboratory. The purpose of this study is to show the preliminary results of the experimental investigation. The laboratory embankment was built using material coming from a real levee and gathered inside a 1.5m x 1.2m plexiglas box. The box has two compartments: a water reservoir at one hand where a constant water head was reached after some time and a soil simulating the presence of levee. We perform a geoelectrical multichannel acquisition system with three parallel profiles characterized by 16 mini-electrodes connected to georesistivimeter Syscal Pro. An automatic acquisition protocol has been performed to obtain time slice electrical tomographies during the experiments. The geophysical results show the effect of the water table inside the embankment during the wetting and emptying. In order to assess the capability of the geophysical monitoring for addressing the soil parameters estimate, the resistivity results are investigated by using two analytical and one hydraulic numerical models. The analytical models represent a linear

  3. Face Aging Effect Simulation Using Hidden Factor Analysis Joint Sparse Representation

    Science.gov (United States)

    Yang, Hongyu; Huang, Di; Wang, Yunhong; Wang, Heng; Tang, Yuanyan

    2016-06-01

    Face aging simulation has received rising investigations nowadays, whereas it still remains a challenge to generate convincing and natural age-progressed face images. In this paper, we present a novel approach to such an issue by using hidden factor analysis joint sparse representation. In contrast to the majority of tasks in the literature that handle the facial texture integrally, the proposed aging approach separately models the person-specific facial properties that tend to be stable in a relatively long period and the age-specific clues that change gradually over time. It then merely transforms the age component to a target age group via sparse reconstruction, yielding aging effects, which is finally combined with the identity component to achieve the aged face. Experiments are carried out on three aging databases, and the results achieved clearly demonstrate the effectiveness and robustness of the proposed method in rendering a face with aging effects. Additionally, a series of evaluations prove its validity with respect to identity preservation and aging effect generation.

  4. Experimental Analysis of Bisbenzocyclobutene Bonded Capacitive Micromachined Ultrasonic Transducers.

    Science.gov (United States)

    Manwar, Rayyan; Chowdhury, Sazzadur

    2016-01-01

    Experimental measurement results of a 1.75 mm × 1.75 mm footprint area Capacitive Micromachined Ultrasonic Transducer (CMUT) planar array fabricated using a bisbenzocyclobutene (BCB)-based adhesive wafer bonding technique has been presented. The array consists of 40 × 40 square diaphragm CMUT cells with a cavity thickness of 900 nm and supported by 10 µm wide dielectric spacers patterned on a thin layer of BCB. A 150 µm wide one µm thick gold strip has been used as the contact pad for gold wire bonding. The measured resonant frequency of 19.3 MHz using a Polytec™ laser Doppler vibrometer (Polytec™ MSA-500) is in excellent agreement with the 3-D FEA simulation result using IntelliSuite™. An Agilent ENA5061B vector network analyzer (VNA) has been used for impedance measurement and the resonance and anti-resonance values from the imaginary impedance curve were used to determine the electromechanical coupling co-efficient. The measured coupling coefficient of 0.294 at 20 V DC bias exhibits 40% higher transduction efficiency as compared to a measured value published elsewhere for a silicon nitride based CMUT. A white light interferometry method was used to measure the diaphragm deflection profiles at different DC bias. The diaphragm center velocity was measured for different sub-resonant frequencies using a Polytec™ laser Doppler vibrometer that confirms vibration of the diaphragm at different excitation frequencies and bias voltages. Transmit and receive operations of CMUT cells were characterized using a pitch-catch method and a -6 dB fractional bandwidth of 23% was extracted from the received signal in frequency domain. From the measurement, it appears that BCB-based CMUTs offer superior transduction efficiency as compared to silicon nitride or silicon dioxide insulator-based CMUTs, and provide a very uniform deflection profile thus making them a suitable candidate to fabricate highly energy efficient CMUTs. PMID:27347955

  5. Merit and justice: an experimental analysis of attitude to inequality.

    Science.gov (United States)

    Rustichini, Aldo; Vostroknutov, Alexander

    2014-01-01

    Merit and justice play a crucial role in ethical theory and political philosophy. Some theories view justice as allocation according to merit; others view justice as based on criteria of its own, and take merit and justice as two independent values. We study experimentally how these views are perceived. In our experiment subjects played two games (both against the computer): a game of skill and a game of luck. After each game they observed the earnings of all the subjects in the session, and thus the differences in outcomes. Each subject could reduce the winnings of one other person at a cost. The majority of the subjects used the option to subtract. The decision to subtract and the amount subtracted depended on whether the game was one of skill or luck, and on the distance between the earnings of the subject and those of others. Everything else being equal, subjects subtracted more in luck than in skill. In skill game, but not in luck, the subtraction becomes more likely, and the amount larger, as the distance increases. The results show that individuals considered favorable outcomes in luck to be undeserved, and thus felt more justified in subtracting. In the skill game instead, they considered more favorable outcomes (their own as well as others') as signal of ability and perhaps effort, which thus deserved merit; hence, they felt less motivated to subtract. However, a larger size of the unfavorable gap from the others increased the unpleasantness of poor performance, which in turn motivated larger subtraction. In conclusion, merit is attributed if and only if effort or skill significantly affect the outcome. An inequality of outcomes is viewed differently depending on whether merit causes the difference or not. Thus, merit and justice are strongly linked in the human perception of social order.

  6. Single photon laser altimeter data processing, analysis and experimental validation

    Science.gov (United States)

    Vacek, Michael; Peca, Marek; Michalek, Vojtech; Prochazka, Ivan

    2015-10-01

    Spaceborne laser altimeters are common instruments on-board the rendezvous spacecraft. This manuscript deals with the altimeters using a single photon approach, which belongs to the family of time-of-flight range measurements. Moreover, the single photon receiver part of the altimeter may be utilized as an Earth-to-spacecraft link enabling one-way ranging, time transfer and data transfer. The single photon altimeters evaluate actual altitude through the repetitive detections of single photons of the reflected laser pulses. We propose the single photon altimeter signal processing and data mining algorithm based on the Poisson statistic filter (histogram method) and the modified Kalman filter, providing all common altimetry products (altitude, slope, background photon flux and albedo). The Kalman filter is extended for the background noise filtering, the varying slope adaptation and the non-causal extension for an abrupt slope change. Moreover, the algorithm partially removes the major drawback of a single photon altitude reading, namely that the photon detection measurement statistics must be gathered. The developed algorithm deduces the actual altitude on the basis of a single photon detection; thus, being optimal in the sense that each detected signal photon carrying altitude information is tracked and no altitude information is lost. The algorithm was tested on the simulated datasets and partially cross-probed with the experimental data collected using the developed single photon altimeter breadboard based on the microchip laser with the pulse energy on the order of microjoule and the repetition rate of several kilohertz. We demonstrated that such an altimeter configuration may be utilized for landing or hovering a small body (asteroid, comet).

  7. Experimental study and mechanism analysis on bioeffects by nanosecond electromagnetic pulses

    Institute of Scientific and Technical Information of China (English)

    王保义; 杨杰斌; 郭庆功; 徐润民; 刘长军; 张弘; 邹方东; 王子淑

    1997-01-01

    The athermal bioeffects caused by nanosecond electromagnetic pulses with body cells was studied by using a broad band transverse EM-wave cell (BTEM CELL). The experimental system and preliminary mechanism analysis were presented.

  8. Experimental and numerical analysis of Al6063 duralumin using Taylor impact test

    Science.gov (United States)

    Kruszka, L.; Anaszewicz, Ł.; Janiszewski, J.; Grązka, M.

    2012-08-01

    The paper presents results of experimental and numerical analysis of dynamic behaviour Al6063 duralumin. Dynamical experiments were made using Taylor impact test. Experimental results at next step of study were used in numerical analyses of dynamic yield stress of tested material and model parameters of the Johnson-Cook constitutive equation. The main aim of this analysis is to find out dynamical properties of Al6063 duralumin tested in Taylor impact test.

  9. Experimental and numerical analysis of Al6063 duralumin using Taylor impact test

    Directory of Open Access Journals (Sweden)

    Grązka M.

    2012-08-01

    Full Text Available The paper presents results of experimental and numerical analysis of dynamic behaviour Al6063 duralumin. Dynamical experiments were made using Taylor impact test. Experimental results at next step of study were used in numerical analyses of dynamic yield stress of tested material and model parameters of the Johnson–Cook constitutive equation. The main aim of this analysis is to find out dynamical properties of Al6063 duralumin tested in Taylor impact test.

  10. Analysis of Lower Body Kinematic and Kinetic: Differences Between Age and Handicap in Golfers of Various Ages and Skill Levels

    Science.gov (United States)

    Smilensky, Alexander

    The purpose of this thesis was to provide a preliminary analysis of lower body golf swing biomechanics. Fourteen golfers of various ages and handicaps performed 10 swings off a tee with their driver. This study focused on a number of dependent variables including lead knee joint flexion angles, internal/external rotations, valgus/varus angles, as well as ground reaction forces normalized to body weight (%BW), X-Factor angle and club head velocity. Dependent variables were analyzed at four specifically defined events (start, initiation of downswing, contact and swing termination). Simple linear regressions were performed using age and handicap as independent variables to see if patterns could be determined at any of the events. No significant trends or results were reported within our sample. An analysis of variance (ANOVA) was then used to examine the effect of event on specific dependent variables. A number of differences were reported within each of the variables across the four events. This study hoped to provide a more comprehensive understanding of the movement patterns occurring at the lower body with special focus on the lead knee.

  11. An analysis of linguistic styles by inferred age in tv dramas.

    Science.gov (United States)

    Lee, Chang H; Park, Jongmin; Seo, Young Seok

    2006-10-01

    A language analysis program, Linguistic Inquiry and Word Count (LIWC), was successful in identifying various psychological variables. This study investigated the relationship between spoken language and age inferred from drama scripts of 162 characters, analyzed by the Korean-LIWC across 4 age categories (10-19, 20-39, 40-59, and 60-79 years). Analysis indicated that younger characters use fewer phrases, morphemes, nouns, auxiliary words, and adverbs than older characters, suggesting less cognitive development of younger characters. In addition, younger characters used less positive words for emotion and achievement than older characters. These data appear contrary to the negative stereotypes of aging people. PMID:17153803

  12. Wireless sensor networks concepts, applications, experimentation and analysis

    CERN Document Server

    Fahmy, Hossam Mahmoud Ahmad

    2016-01-01

    This book focuses on the principles of wireless sensor networks (WSNs), their applications, and their analysis tools, with meticulous attention paid to definitions and terminology. This book presents the adopted technologies and their manufacturers in detail, making WSNs tangible for the reader. In introductory computer networking books, chapter sequencing follows the bottom-up or top-down architecture of the 7-layer protocol. This book addresses subsequent steps in this process, both horizontally and vertically, thus fostering a clearer and deeper understanding through chapters that elaborate on WSN concepts and issues. With such depth, this book is intended for a wide audience; it is meant to be a helper and motivator for senior undergraduates, postgraduates, researchers, and practitioners. It lays out important concepts and WSN-relate applications; uses appropriate literature to back research and practical issues; and focuses on new trends. Senior undergraduate students can use it to familiarize themselves...

  13. Probing beer aging chemistry by nuclear magnetic resonance and multivariate analysis

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, J.A. [CICECO-Department of Chemistry, University of Aveiro, Campus de Santiago, 3810-193 Aveiro (Portugal); Barros, A.S. [QOPNA-Department of Chemistry, University of Aveiro, Campus de Santiago, 3810-193 Aveiro (Portugal); Carvalho, B.; Brandao, T. [UNICER, Bebidas de Portugal, Leca do Balio, 4466-955, S. Mamede de Infesta (Portugal); Gil, Ana M., E-mail: agil@ua.pt [CICECO-Department of Chemistry, University of Aveiro, Campus de Santiago, 3810-193 Aveiro (Portugal)

    2011-09-30

    Graphical abstract: The use of nuclear magnetic resonance (NMR) metabonomics for monitoring the chemical changes occurring in beer exposed to forced aging (at 45 deg. C for up to 18 days) is described. Both principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) were applied to the NMR spectra of beer recorded as a function of aging and an aging trend was observed. Inspection of PLS-DA loadings and peak integration revealed the importance of well known markers (e.g. 5-HMF) as well as of other compounds: amino acids, higher alcohols, organic acids, dextrins and some still unassigned spin systems. 2D correlation analysis enabled relevant compound variations to be confirmed and inter-compound correlations to be assessed, thus offering improved insight into the chemical aspects of beer aging. Highlights: {center_dot} Use of NMR metabonomics for monitoring the chemical changes occurring in beer exposed to forced aging. {center_dot} Compositional variations evaluated by principal component analysis and partial least squares-discriminant analysis. {center_dot} Results reveal importance of known markers and other compounds: amino and organic acids, higher alcohols, dextrins. {center_dot} 2D correlation analysis reveals inter-compound relationships, offering insight into beer aging chemistry. - Abstract: This paper describes the use of nuclear magnetic resonance (NMR) spectroscopy, in tandem with multivariate analysis (MVA), for monitoring the chemical changes occurring in a lager beer exposed to forced aging (at 45 deg. C for up to 18 days). To evaluate the resulting compositional variations, both principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) were applied to the NMR spectra of beer recorded as a function of aging and a clear aging trend was observed. Inspection of PLS-DA loadings and peak integration enabled the changing compounds to be identified, revealing the importance of well known

  14. Practical applications of age-dependent reliability models and analysis of operational data

    International Nuclear Information System (INIS)

    The purpose of the workshop was to present the experience of practical application of time-dependent reliability models. The program of the workshop comprises the following sessions: -) aging management and aging PSA (Probabilistic Safety Assessment), -) modeling, -) operation experience, and -) accelerating aging tests. In order to introduce time aging effect of particular component to the PSA model, it has been proposed to use the constant unavailability values on the short period of time (one year for example) calculated on the basis of age-dependent reliability models. As for modeling, it appears that the problem of too detailed statistical models for application is the lack of data for required parameters. As for operating experience, several methods of operating experience analysis have been presented (algorithms for reliability data elaboration and statistical identification of aging trend). As for accelerated aging tests, it is demonstrated that a combination of operating experience analysis with the results of accelerated aging tests of naturally aged equipment could provide a good basis for continuous operation of instrumentation and control systems

  15. Practical applications of age-dependent reliability models and analysis of operational data

    Energy Technology Data Exchange (ETDEWEB)

    Lannoy, A.; Nitoi, M.; Backstrom, O.; Burgazzi, L.; Couallier, V.; Nikulin, M.; Derode, A.; Rodionov, A.; Atwood, C.; Fradet, F.; Antonov, A.; Berezhnoy, A.; Choi, S.Y.; Starr, F.; Dawson, J.; Palmen, H.; Clerjaud, L

    2005-07-01

    The purpose of the workshop was to present the experience of practical application of time-dependent reliability models. The program of the workshop comprises the following sessions: -) aging management and aging PSA (Probabilistic Safety Assessment), -) modeling, -) operation experience, and -) accelerating aging tests. In order to introduce time aging effect of particular component to the PSA model, it has been proposed to use the constant unavailability values on the short period of time (one year for example) calculated on the basis of age-dependent reliability models. As for modeling, it appears that the problem of too detailed statistical models for application is the lack of data for required parameters. As for operating experience, several methods of operating experience analysis have been presented (algorithms for reliability data elaboration and statistical identification of aging trend). As for accelerated aging tests, it is demonstrated that a combination of operating experience analysis with the results of accelerated aging tests of naturally aged equipment could provide a good basis for continuous operation of instrumentation and control systems.

  16. Errors in experimental design and statistical analysis of aquaculture diet evaluation studies induced by filtration systems

    Directory of Open Access Journals (Sweden)

    Michael F. Tlusty

    2010-07-01

    Full Text Available While single factor diet studies appear to be of simple design, the space constraints in aquaculture caused by the need to filter the aqueous media often c reate constraints on the implementation of the experimental design. A number of papers have been published in which the experimental design and subsequent analysis is incorrect. This paper reviews the principles of experimental design as it related to single factor diet evaluation studies in aquaculture. By adhering tosimple design principles to ensure that experimental units are independent, the data generated by future experiments will be of high quality and results more robust.

  17. Age estimation using pulp/tooth area ratio: A digital image analysis

    Directory of Open Access Journals (Sweden)

    Sasidhar Singaraju

    2009-01-01

    Full Text Available Age is one of the essential factors in establishing the identity of the person. Estimation of the human age is a procedure adopted by anthropologists, archeologists, and forensic scientists. Inspection of radiographs and subsequent comparison with radiographic images, in charts yield ′maturity scores′ that help us to assess the age of an individual. Alternative approaches based on digitalization of panoramic radiographs and their computerized storage have recently become available that exploit image analysis to obtain nondestructive metric measurements of both pulp chambers and teeth, which can be used to assess the age of an individual. The purpose of the present study was to present a method for assessing the chronological age based on the relationship between age and measurement of the pulp/tooth area ratio on single-rooted teeth, using orthopantomographs and a computer-aided drafting program AutoCAD 2000.

  18. Pricing Strategies under Emissions Trading - an experimental analysis

    Energy Technology Data Exchange (ETDEWEB)

    Wraake, Markus; Myers, Erica; Mandell, Svante; Holt, Charles; Burtraw, Dallas

    2008-10-15

    An important feature in the design of an emissions trading program is how emission allowances are initially distributed into the market. The choice between an auction and free allocation should, according to economic theory, not have any influence on the firms' production choices nor on consumer prices. However, many observers are still incredulous that firms should be expected to raise product prices to include the value of emissions allowances they receive for free. Throughout much of Europe and the U.S., energy markets have been deregulated or are in the process of moving toward market liberalization. If market behavior does not conform to predictions of behavior in a competitive market, this may say a great deal about the nature of market liberalization in energy markets as well as about the behavior of environmental markets. If firms are able to voluntarily moderate commodity prices to be below competitive levels, it suggests an ability of these entities to exercise market power or collude - even if this is motivated by a desire to hold back and not pass through the value of emissions allowances in product prices. This paper reports on the use of experimental methods to investigate behavior with respect to how prices will be determined under a cap-and-trade program. We find participants in the experiments employ various approaches. Some participants initially recognize the opportunity cost of emission allowances and included them in their economic choices regardless of how the allowances have been obtained, and other subjects initially do not. However, given a simple economic setting in which payoffs depend on this behavior, we find that subjects learn to consider the value of allowances and overall behavior moves toward that predicted by economic theory. The observations from the experiments may help to understand the ongoing public debate over the interaction of the EU ETS and energy markets. Emission allowance markets are a new phenomenon to many

  19. Experimental and computational analysis of composite ankle-foot orthosis

    Directory of Open Access Journals (Sweden)

    Dequan Zou, DSc

    2015-03-01

    Full Text Available Carbon fiber (CF ankle-foot orthoses (AFOs can improve gait by increasing ankle plantar-flexor power and improving plantar-flexor ankle joint moment and energy efficiency compared with posterior leaf spring AFOs made of thermoplastic. However, fabricating a CF AFO to optimize the performance of the individual user may require multiple AFOs and expensive fabrication costs. Finite element analysis (FEA models were developed to predict the mechanical behavior of AFOs in this study. Three AFOs, two made of CF composite material and one made of thermoplastic material, were fabricated and then mechanically tested to produce force-displacement data. The FEA models were validated by comparing model predictions with mechanical testing data performed under the same loading and boundary conditions. The actual mechanical testing demonstrated that CF performs better than thermoplastic. The simulation results showed that FEA models produced accurate predictions for both types of orthoses. The relative error of the energy return ratio predicted by the CF AFO FEA model developed in this study is less than 3%. We conclude that highly accurate FEA models will allow orthotists to improve CF AFO fabrication without wasting resources (time and money on trial and error fabrications that are expensive and do not consistently improve AFO and user performance.

  20. Experimental and computational analysis of composite ankle-foot orthosis.

    Science.gov (United States)

    Zou, Dequan; He, Tao; Dailey, Michael; Smith, Kirk E; Silva, Matthew J; Sinacore, David R; Mueller, Michael J; Hastings, Mary K

    2014-01-01

    Carbon fiber (CF) ankle-foot orthoses (AFOs) can improve gait by increasing ankle plantar-flexor power and improving plantar-flexor ankle joint moment and energy efficiency compared with posterior leaf spring AFOs made of thermoplastic. However, fabricating a CF AFO to optimize the performance of the individual user may require multiple AFOs and expensive fabrication costs. Finite element analysis (FEA) models were developed to predict the mechanical behavior of AFOs in this study. Three AFOs, two made of CF composite material and one made of thermoplastic material, were fabricated and then mechanically tested to produce force-displacement data. The FEA models were validated by comparing model predictions with mechanical testing data performed under the same loading and boundary conditions. The actual mechanical testing demonstrated that CF performs better than thermoplastic. The simulation results showed that FEA models produced accurate predictions for both types of orthoses. The relative error of the energy return ratio predicted by the CF AFO FEA model developed in this study is less than 3%. We conclude that highly accurate FEA models will allow orthotists to improve CF AFO fabrication without wasting resources (time and money) on trial and error fabrications that are expensive and do not consistently improve AFO and user performance. PMID:25856154

  1. Fabrication and Experimental Analysis of Axially Oriented Nanofibers.

    Science.gov (United States)

    Aphale, Ashish N; Mahakalkar, Kapil; Macwan, Isaac G; Mukerji, Ishita; Cox, Paris J; Mahapatra, Manoj; Singh, Prabhakar; Ajayan, Pulickel M; Patra, Prabir K

    2016-03-01

    A novel design of a laboratory built axially rotating collector (ARC) having capability to align electrospun nanofibers have been described. A detailed morphological comparison of such nanofibers orientation and their geometry is done using scanning electron microscopy (SEM). For comparison various polymeric solutions were electrospun on conventional static collector as well as ARC. The average diameter of polyvinyl alcohol (PVA) nanofibers was found to be 250 nm while polycaprolactone (PCL) nanofibers were found to be within a range of 600-800 nm. Conducting nanoparticles such as graphene and multi-walled carbon nanotubes (MWNTs) mixed with polymer solutions shown to have a significant influence on the overall geometry of these nanofibers and their diameter distribution. It is evident from the SEM analysis that both graphene and MWNTs in polymer solution play a crucial role in achieving a uniform diameter of nanofibers. Lastly, the formation of the aligned nanofibers using ARC has been mathematically modeled and the electromagnetic field governing the process has been simulated. PMID:27455687

  2. New developments for experimental modal analysis of aircraft structures

    Directory of Open Access Journals (Sweden)

    Vayssettes Jérémy

    2015-01-01

    Full Text Available This article presents an identification algorithm dedicated to the modal analysis of aircraft structures during flight-tests. More specifically, this algorithm was designed to process short duration tests carried out with multi-input excitations. The identification problem is solved in the frequency domain and the limit effects are considered so as to avoid transient effects with short data sequences. To minimise the effects of the noise, a non-linear gradient-based optimisation method is used. Its performance is improved by the use of an appropriate over-parametrised matrix fraction descriptions. Because the cost function to be minimised is non-convex, this method is however sensitive to the initialisation. For this reason, an iterative instrumental variable method is used to find an initial estimate. This one gives a value of the cost-function sufficiently close to its global minimum so as to ensure a fast convergence of the optimisation. Thus, the algorithm presented in this article is a combination of two iterative methods that gives accurate mode estimations even with high level of noise, as shown on an illustrative example.

  3. Experimental and computational analysis of composite ankle-foot orthosis.

    Science.gov (United States)

    Zou, Dequan; He, Tao; Dailey, Michael; Smith, Kirk E; Silva, Matthew J; Sinacore, David R; Mueller, Michael J; Hastings, Mary K

    2014-01-01

    Carbon fiber (CF) ankle-foot orthoses (AFOs) can improve gait by increasing ankle plantar-flexor power and improving plantar-flexor ankle joint moment and energy efficiency compared with posterior leaf spring AFOs made of thermoplastic. However, fabricating a CF AFO to optimize the performance of the individual user may require multiple AFOs and expensive fabrication costs. Finite element analysis (FEA) models were developed to predict the mechanical behavior of AFOs in this study. Three AFOs, two made of CF composite material and one made of thermoplastic material, were fabricated and then mechanically tested to produce force-displacement data. The FEA models were validated by comparing model predictions with mechanical testing data performed under the same loading and boundary conditions. The actual mechanical testing demonstrated that CF performs better than thermoplastic. The simulation results showed that FEA models produced accurate predictions for both types of orthoses. The relative error of the energy return ratio predicted by the CF AFO FEA model developed in this study is less than 3%. We conclude that highly accurate FEA models will allow orthotists to improve CF AFO fabrication without wasting resources (time and money) on trial and error fabrications that are expensive and do not consistently improve AFO and user performance.

  4. An Analysis of Excavation Support Safety Based on Experimental Studies

    Directory of Open Access Journals (Sweden)

    Gorska Karolina

    2015-09-01

    Full Text Available The article presents the results of inclinometric measurements and numerical analyses of soldier-pile wall displacements. The excavation under investigation was made in cohesive soils. The measurements were conducted at points located at the edge of the cantilever excavation support system. The displacements of the excavation support observed over the period of three years demonstrated the pattern of steady growth over the first two months, followed by a gradual levelling out to a final plateau. The numerical analyses were conducted based on 3D FEM models. The numerical analysis of the problem comprise calculations of the global structural safety factor depending on the displacement of the chosen points in the lagging and conducted by means of the φ/c reduction procedure. The adopted graphical method of safety estimation is very conservative in the sense that it recognizes stability loss quite early, when one could further load the medium or weaken it by further strength reduction. The values of the Msf factor are relatively high. This is caused by the fact that the structure was designed for excavation twice as deep. Nevertheless, the structure is treated as a temporary one.

  5. An Analysis of Excavation Support Safety Based on Experimental Studies

    Science.gov (United States)

    Gorska, Karolina; Wyjadłowski, Marek

    2015-09-01

    The article presents the results of inclinometric measurements and numerical analyses of soldier-pile wall displacements. The excavation under investigation was made in cohesive soils. The measurements were conducted at points located at the edge of the cantilever excavation support system. The displacements of the excavation support observed over the period of three years demonstrated the pattern of steady growth over the first two months, followed by a gradual levelling out to a final plateau. The numerical analyses were conducted based on 3D FEM models. The numerical analysis of the problem comprise calculations of the global structural safety factor depending on the displacement of the chosen points in the lagging and conducted by means of the φ/c reduction procedure. The adopted graphical method of safety estimation is very conservative in the sense that it recognizes stability loss quite early, when one could further load the medium or weaken it by further strength reduction. The values of the Msf factor are relatively high. This is caused by the fact that the structure was designed for excavation twice as deep. Nevertheless, the structure is treated as a temporary one.

  6. Operation and management manual of JT-60 experimental data analysis system

    International Nuclear Information System (INIS)

    In the Japan Atomic Energy Agency Naka Fusion Institute, a lot of experiments have been conducted by using the large tokamak device JT-60 aiming to realize fusion power plant. In order to optimize the JT-60 experiment and to investigate complex characteristics of plasma, JT-60 experimental data analysis system was developed and used for collecting, referring and analyzing the JT-60 experimental data. Main components of the system are a data analysis server and a database server for the analyses and accumulation of the experimental data respectively. Other peripheral devices of the system are magnetic disk units, NAS (Network Attached Storage) device, and a backup tape drive. This is an operation and management manual the JT-60 experimental data analysis system. (author)

  7. The application of analysis of variance (ANOVA) to different experimental designs in optometry.

    Science.gov (United States)

    Armstrong, R A; Eperjesi, F; Gilmartin, B

    2002-05-01

    Analysis of variance (ANOVA) is the most efficient method available for the analysis of experimental data. Analysis of variance is a method of considerable complexity and subtlety, with many different variations, each of which applies in a particular experimental context. Hence, it is possible to apply the wrong type of ANOVA to data and, therefore, to draw an erroneous conclusion from an experiment. This article reviews the types of ANOVA most likely to arise in clinical experiments in optometry including the one-way ANOVA ('fixed' and 'random effect' models), two-way ANOVA in randomised blocks, three-way ANOVA, and factorial experimental designs (including the varieties known as 'split-plot' and 'repeated measures'). For each ANOVA, the appropriate experimental design is described, a statistical model is formulated, and the advantages and limitations of each type of design discussed. In addition, the problems of non-conformity to the statistical model and determination of the number of replications are considered.

  8. Plutonium Worlds. Fast Breeders, Systems Analysis and Computer Simulation in the Age of Hypotheticality

    Directory of Open Access Journals (Sweden)

    Sebastian Vehlken

    2014-09-01

    Full Text Available This article examines the media history of one of the hallmark civil nuclear energy programs in Western Germany – the development of Liquid Metal Fast Breeder Reactor (LMFBR technology. Promoted as a kind of perpetuum mobile of the Atomic Age, the "German Manhattan Project" not only imported big science thinking. In its context, nuclear technology was also put forth as an avantgarde of scientific inquiry, dealing with the most complex and critical technological endeavors. In the face of the risks of nuclear technology, German physicist Wolf Häfele thus announced a novel epistemology of "hypotheticality". In a context where traditional experimental engineering strategies became inappropiate, he called for the application of advanced media technologies: Computer Simulations (CS and Systems Analysis (SA generated computerized spaces for the production of knowledge. In the course of the German Fast Breeder program, such methods had a twofold impact. One the one hand, Häfele emphazised – as the "father of the German Fast Breeder" – the utilization of CS for the actual planning and construction of the novel reactor type. On the other, namely as the director of the department of Energy Systems at the International Institute for Applied Systems Analysis (IIASA, Häfele advised SA-based projections of energy consumption. These computerized scenarios provided the rationale for the conception of Fast Breeder programs as viable and necessary alternative energy sources in the first place. By focusing on the role of the involved CS techniques, the paper thus investigates the intertwined systems thinking of nuclear facilities’s planning and construction and the design of large-scale energy consumption and production scenarios in the 1970s and 1980s, as well as their conceptual afterlives in our contemporary era of computer simulation.

  9. Experimental data required for the design and analysis of emergency filtered air discharge sytems

    International Nuclear Information System (INIS)

    The radiological consequences of an accident in a CANDU nuclear generating station are mitigated by special safety systems which include an Emergency Filtered Air Discharge (EFAD) system. EFAD systems are designed to provide a controlled leakage path following an accident. They remove radioiodine and particulates from the air discharge required, to inhibit uncontrolled emissions by maintaining containment sub-atmospheric in the long term. The design and analysis of an EFAD system requires an accurate data base comprised of the numerous parameters involved in the simulation of fission product behaviour within containment. This paper emphasizes the data requirements of EFAD system design with regard to those parameters which preliminary sensitivity analyses have shown to most effect environmental releases. These include the source term radioisotopes; their chemical behaviour and distribution within containment; the repressurization time during the vacuum hold-up period; and parameters effecting the long term releases through the EFAD system. The net radioiodine trapping efficiency of charcoal filters in the long term is dependent on the adsorption efficiency and desorption of the deep charcoal bed. These are a function of many parameters such as impregnate, aging, humidity, temperature, radiation, recirculation, etc. Although the effect of these parameters on charcoal filters has been individually investigated, generally at ideal or extreme values, there is little applicable data to determine their combined effect under expected post accident operating conditions. As a consequence, designers tend to overdesign by using unduly conservative parameters. A summary comparison is presented to illustrate the information gap between the experimental data from the literature and the data required for optimal design and analysis of the EFAD systems

  10. Probabilistic fracture mechanics analysis of thermally aged nuclear piping in a pressurized water reactor

    International Nuclear Information System (INIS)

    Highlights: • Thermal aging embrittlement was considered in the PFM analysis of nuclear pipe. • Predicting program for pipe failure probability was developed based on thermal aging. • Cumulative failure probability is significantly affected by fracture toughness. • Cumulative failure probability is slightly affected by fatigue crack growth rate. • Tensile strength increase due to thermal aging slightly reduces pipe failure risk. - Abstract: A predicting program for pipe break probability based on thermal aging embrittlement was developed. In order for life prediction, evolutions of fracture toughness and tensile strength were estimated for a Z3CN20-09M piping steel using the Argonne National Laboratory (ANL) procedure. To understand the influence of thermal aging on failure probability, different evolutions of fracture toughness, tensile strength and fatigue crack growth rate were employed in the prediction of cumulative failure probability. The results show that the cumulative failure probability for 40-year thermal aging increases by almost four times compared to without consideration of fracture toughness degradation. The cumulative failure probability is slightly affected by fatigue crack growth rate. The increase of tensile strength due to thermal aging reduces the risk of pipe failure. This work demonstrates that the degradation of fracture toughness due to thermal aging should be fully considered in the probabilistic fracture mechanics analysis of nuclear pressure pipes

  11. Probabilistic fracture mechanics analysis of thermally aged nuclear piping in a pressurized water reactor

    Energy Technology Data Exchange (ETDEWEB)

    Li, Shuxiao; Zhang, Hailong; Li, Shilei; Wang, Yanli [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China); Xue, Fei [Suzhou Nuclear Power Research Institute, Suzhou 215004 (China); Wang, Xitao, E-mail: xtwang@ustb.edu.cn [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China)

    2013-12-15

    Highlights: • Thermal aging embrittlement was considered in the PFM analysis of nuclear pipe. • Predicting program for pipe failure probability was developed based on thermal aging. • Cumulative failure probability is significantly affected by fracture toughness. • Cumulative failure probability is slightly affected by fatigue crack growth rate. • Tensile strength increase due to thermal aging slightly reduces pipe failure risk. - Abstract: A predicting program for pipe break probability based on thermal aging embrittlement was developed. In order for life prediction, evolutions of fracture toughness and tensile strength were estimated for a Z3CN20-09M piping steel using the Argonne National Laboratory (ANL) procedure. To understand the influence of thermal aging on failure probability, different evolutions of fracture toughness, tensile strength and fatigue crack growth rate were employed in the prediction of cumulative failure probability. The results show that the cumulative failure probability for 40-year thermal aging increases by almost four times compared to without consideration of fracture toughness degradation. The cumulative failure probability is slightly affected by fatigue crack growth rate. The increase of tensile strength due to thermal aging reduces the risk of pipe failure. This work demonstrates that the degradation of fracture toughness due to thermal aging should be fully considered in the probabilistic fracture mechanics analysis of nuclear pressure pipes.

  12. Quantification of Age-Related Tissue-Level Failure Strains of Rat Femoral Cortical Bones Using an Approach Combining Macrocompressive Test and Microfinite Element Analysis.

    Science.gov (United States)

    Fan, Ruoxun; Gong, He; Zhang, Rui; Gao, Jiazi; Jia, Zhengbin; Hu, Yanjuan

    2016-04-01

    Bone mechanical properties vary with age; meanwhile, a close relationship exists among bone mechanical properties at different levels. Therefore, conducting multilevel analyses for bone structures with different ages are necessary to elucidate the effects of aging on bone mechanical properties at different levels. In this study, an approach that combined microfinite element (micro-FE) analysis and macrocompressive test was established to simulate the failure of male rat femoral cortical bone. Micro-FE analyses were primarily performed for rat cortical bones with different ages to simulate their failure processes under compressive load. Tissue-level failure strains in tension and compression of these cortical bones were then back-calculated by fitting the experimental stress-strain curves. Thus, tissue-level failure strains of rat femoral cortical bones with different ages were quantified. The tissue-level failure strain exhibited a biphasic behavior with age: in the period of skeletal maturity (1-7 months of age), the failure strain gradually increased; when the rat exceeded 7 months of age, the failure strain sharply decreased. In the period of skeletal maturity, both the macro- and tissue-levels mechanical properties showed a large promotion. In the period of skeletal aging (9-15 months of age), the tissue-level mechanical properties sharply deteriorated; however, the macromechanical properties only slightly deteriorated. The age-related changes in tissue-level failure strain were revealed through the analysis of male rat femoral cortical bones with different ages, which provided a theoretical basis to understand the relationship between rat cortical bone mechanical properties at macro- and tissue-levels and decrease of bone strength with age. PMID:26902102

  13. Experimental Tityus serrulatus scorpion envenomation: age- and sex-related differences in symptoms and mortality in mice

    Directory of Open Access Journals (Sweden)

    Pucca MB

    2011-01-01

    Full Text Available Among the various methods for evaluating animal venom toxicity, the calculation of the median lethal dose (LD50 is the most widely used. Although different protocols can be used to calculate the LD50, the source of the venom and the method of extraction, as well as the strain, age, and sex of the animal model employed, should be taken into consideration. The objective of the present study was to evaluate the influence of sex and age on the toxicity of Tityus serrulatus scorpion venom in Swiss mice. Although the symptoms of envenomation were similar in male and female animals, female mice proved to be more resistant to the venom. In females, age had no impact on the susceptibility to scorpion envenomation. Male mice were more sensitive to T. serrulatus venom. Moreover, in males, age was an important parameter since sensitivity to the venom increased with age.

  14. 40 CFR 158.2171 - Experimental use permit microbial pesticides product analysis data requirements table.

    Science.gov (United States)

    2010-07-01

    ... pesticides product analysis data requirements table. 158.2171 Section 158.2171 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Microbial Pesticides § 158.2171 Experimental use permit microbial pesticides product analysis data requirements...

  15. Age-Specific Gene Expression Profiles of Rhesus Monkey Ovaries Detected by Microarray Analysis

    Directory of Open Access Journals (Sweden)

    Hengxi Wei

    2015-01-01

    Full Text Available The biological function of human ovaries declines with age. To identify the potential molecular changes in ovarian aging, we performed genome-wide gene expression analysis by microarray of ovaries from young, middle-aged, and old rhesus monkeys. Microarray data was validated by quantitative real-time PCR. Results showed that a total of 503 (60 upregulated, 443 downregulated and 84 (downregulated genes were differentially expressed in old ovaries compared to young and middle-aged groups, respectively. No difference in gene expression was found between middle-aged and young groups. Differentially expressed genes were mainly enriched in cell and organelle, cellular and physiological process, binding, and catalytic activity. These genes were primarily associated with KEGG pathways of cell cycle, DNA replication and repair, oocyte meiosis and maturation, MAPK, TGF-beta, and p53 signaling pathway. Genes upregulated were involved in aging, defense response, oxidation reduction, and negative regulation of cellular process; genes downregulated have functions in reproduction, cell cycle, DNA and RNA process, macromolecular complex assembly, and positive regulation of macromolecule metabolic process. These findings show that monkey ovary undergoes substantial change in global transcription with age. Gene expression profiles are useful in understanding the mechanisms underlying ovarian aging and age-associated infertility in primates.

  16. Synergistic effect of aged garlic extract and naltrexone on improving immune responses to experimentally induced fibrosarcoma tumor in BALB/c mice

    Directory of Open Access Journals (Sweden)

    Soheil Ebrahimpour

    2013-01-01

    Full Text Available Background: Garlic, a medicinal plant, and Naltrexone (NTX, an opioid receptor antagonist, both have immunomodulatory and antitumor effects. Current study was designed to evaluate synergistic antitumor effects of aged garlic extract (AGE and NTX. Materials and Methods: WEHI-164 fibrosarcoma cells were implanted subcutaneously on day 0 into right flank of 80 BALB/c mice at age of 8 weeks. Mice were randomly categorized in four separate groups: The first group received AGE (100 mg/kg, i.p., the second group received NTX (0.5 mg/kg, i.p., the third group received both of them, and the fourth group received phosphate buffered saline as control group. Treatments were administered three times per week. Tumor growth was measured and morbidity was recorded. Subpopulations of CD4+/CD8+ T cells were determined using flowcytometery. WEHI-164 cell specific cytotoxicity of splenocytes and in vitro production of interferon-gamma (IFN-γ and interleukin-4 (IL-4 cytokines were measured. All statistical analyses were conducted with SPSS 16 software and P < 0.05 was considered to be statistically significant. Results: The mice who received AGE+NTX had significantly longer survival time compared with the mice treated with AGE or NTX alone. An enhanced inhibitory effect on tumor growth was seen in combination therapy group. The CD4+/CD8+ ratio and in vitro IFN-γ production of splenocytes were significantly increased in AGE+NTX and NTX groups. WEHI-164 specific cytotoxicity of splenocytes was also significantly increased at 25:1 E:T ratio in AGE+NTX treated mice. Coadministration of AGE with NTX resulted in improvement of immune responses against experimentally implanted fibrosarcoma tumors in BALB/c mice. Conclusions: AGE showed synergistic effects with NTX on inhibition of tumor growth and increment of survival times.

  17. The Analysis of PPG Morphology: Investigating the Effects of Aging on Arterial Compliance

    Science.gov (United States)

    Yousef, Q.; Reaz, M. B. I.; Ali, M. A. M.

    2012-12-01

    This study presents the variations of photoplethysmogram (PPG) morphology with age. PPG measurement is done noninvasively at the index finger on both right and left hands for a sample of erectile dysfunction (ED) subjects. Some parameters are derived from the analysis of PPG contour showed in association with age. The age is found to be an important factor that affects the contour of PPG signals which accelerates the disappearance of PPG’s dicrotic notch and PPG’s inflection point as well. Arterial compliance is found to be degraded with age due to the fall of arterial elasticity. This study approaches the establishment of usefulness of PPG’s contour analysis as an investigator to the changes in the elastic properties of the vascular system, and as a detector of early sub-clinical atherosclerosis.

  18. Aging effect on the fuel behaviors for CANDU fuel safety analysis

    International Nuclear Information System (INIS)

    Because of the aging of heat transport system components, the reactor thermalhydraulic conditions can vary, which may affect the safety response. In a recent safety analysis for the refurbished Wolsong 1 NPP, various aging effects were incorporated into the hydraulic models of the components in the primary heat transport system (PHTS) for conservatism. The aging data of the thermal-hydraulic components for an 11 EFPY of Wolsong 1 were derived based on the site operation data and were modified to the appropriate input data for the thermal-hydraulic code for a safety analysis of a postulated accident. This paper deals with the aging effect of the PHTS of the CANDU reactor on the fuel performance during normal operation and transient period following a postulated accident such as a feeder stagnation break. (author)

  19. Cluster Analysis of Physical and Cognitive Ageing Patterns in Older People from Shanghai

    Directory of Open Access Journals (Sweden)

    Stephan Bandelow

    2016-02-01

    Full Text Available This study investigated the relationship between education, cognitive and physical function in older age, and their respective impacts on activities of daily living (ADL. Data on 148 older participants from a community-based sample recruited in Shanghai, China, included the following measures: age, education, ADL, grip strength, balance, gait speed, global cognition and verbal memory. The majority of participants in the present cohort were cognitively and physically healthy and reported no problems with ADL. Twenty-eight percent of participants needed help with ADL, with the majority of this group being over 80 years of age. Significant predictors of reductions in functional independence included age, balance, global cognitive function (MMSE and the gait measures. Cluster analysis revealed a protective effect of education on cognitive function that did not appear to extend to physical function. Consistency of such phenotypes of ageing clusters in other cohort studies may provide helpful models for dementia and frailty prevention measures.

  20. Cluster Analysis of Physical and Cognitive Ageing Patterns in Older People from Shanghai.

    Science.gov (United States)

    Bandelow, Stephan; Xu, Xin; Xiao, Shifu; Hogervorst, Eef

    2016-01-01

    This study investigated the relationship between education, cognitive and physical function in older age, and their respective impacts on activities of daily living (ADL). Data on 148 older participants from a community-based sample recruited in Shanghai, China, included the following measures: age, education, ADL, grip strength, balance, gait speed, global cognition and verbal memory. The majority of participants in the present cohort were cognitively and physically healthy and reported no problems with ADL. Twenty-eight percent of participants needed help with ADL, with the majority of this group being over 80 years of age. Significant predictors of reductions in functional independence included age, balance, global cognitive function (MMSE) and the gait measures. Cluster analysis revealed a protective effect of education on cognitive function that did not appear to extend to physical function. Consistency of such phenotypes of ageing clusters in other cohort studies may provide helpful models for dementia and frailty prevention measures. PMID:26907351

  1. Newly arrived elderly immigrants: a concept analysis of "aging out of place".

    Science.gov (United States)

    Sadarangani, Tina R; Jun, Jin

    2015-03-01

    Newcomer elderly immigrants, defined as adults older than the age of 65 who have arrived in the United States in the last 10 years, represent a growing sector of the American population. Newcomers who experience limited English proficiency, financial strain, and acculturative stress are at considerable risk of developing poor health outcomes. Nursing's focus on healthy aging and aging in place has largely ignored the experiences of these older adults, who are said to be "aging out of place." This concept analysis uses Rodgers's evolutionary method to define "aging out of place" and illustrates why existing theories of elderly migration do not necessarily apply to this population. The challenge for nurses is incorporating the family, with whom conflict may arise, into the care of these elders. Community-based strategies that enable social integration and create a greater division of labor in the care of newcomer elders are called for. PMID:25217594

  2. Assessment of Cable Aging Equipment, Status of Acquired Materials, and Experimental Matrix at the Pacific Northwest National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Fifield, Leonard S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Westman, Matthew P. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Zwoster, Andy [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Schwenzer, Birgit [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-03-30

    The need for increased understanding of the aging and degradation behavior for polymer components of nuclear power plant electrical cables is described in this report. The highest priority materials for study and the resources available at PNNL for these studies are also described. The anticipated outcomes of the PNNL work described are : improved understanding of appropriate accelerated aging conditions, improved knowledge of correlation between observable aging indicators and cable condition in support of advanced non-destructive evaluation methods, and practical knowledge of condition-based cable lifetime prediction.

  3. Transition in Primary and Secondary Schooling in Pakistan: Gender and Age Cohort Analysis

    OpenAIRE

    Naushin Mahmood

    2004-01-01

    This study assesses the changing pattern of school attendance through age cohort analysis for both males and females in Pakistan. Based on the 1998 census data on educational attainment, the results indicate a profound rise in school attendance among younger age cohorts contributing to elimination of gender gap in primary-level schooling in urban areas only. The disadvantaged situation of rural females is reflected by a combination of low school entries/attendance to begin with, and high chan...

  4. Comparative Meta-Analysis of Transcriptomics Data during Cellular Senescence and In Vivo Tissue Ageing

    OpenAIRE

    Konstantinos Voutetakis; Aristotelis Chatziioannou; Gonos, Efstathios S.; Trougakos, Ioannis P.

    2015-01-01

    Several studies have employed DNA microarrays to identify gene expression signatures that mark human ageing; yet the features underlying this complicated phenomenon remain elusive. We thus conducted a bioinformatics meta-analysis on transcriptomics data from human cell- and biopsy-based microarrays experiments studying cellular senescence or in vivo tissue ageing, respectively. We report that coregulated genes in the postmitotic muscle and nervous tissues are classified into pathways involved...

  5. Analysis of the age of Panax ginseng based on telomere length and telomerase activity.

    Science.gov (United States)

    Liang, Jiabei; Jiang, Chao; Peng, Huasheng; Shi, Qinghua; Guo, Xiang; Yuan, Yuan; Huang, Luqi

    2015-01-23

    Ginseng, which is the root of Panax ginseng (Araliaceae), has been used in Oriental medicine as a stimulant and dietary supplement for more than 7,000 years. Older ginseng plants are substantially more medically potent, but ginseng age can be simulated using unscrupulous cultivation practices. Telomeres progressively shorten with each cell division until they reach a critical length, at which point cells enter replicative senescence. However, in some cells, telomerase maintains telomere length. In this study, to determine whether telomere length reflects ginseng age and which tissue is best for such an analysis, we examined telomerase activity in the main roots, leaves, stems, secondary roots and seeds of ginseng plants of known age. Telomere length in the main root (approximately 1 cm below the rhizome) was found to be the best indicator of age. Telomeric terminal restriction fragment (TRF) lengths, which are indicators of telomere length, were determined for the main roots of plants of different ages through Southern hybridization analysis. Telomere length was shown to be positively correlated with plant age, and a simple mathematical model was formulated to describe the relationship between telomere length and age for P. ginseng.

  6. 40 CFR Appendix Ix to Part 86 - Experimentally Determining the R-Factor for Bench Aging Durability Procedures

    Science.gov (United States)

    2010-07-01

    ... in § 86.1826-08(d)(4). 3. Plot emissions (or catalyst inefficiency) versus aging time for each.... Plot the natural log (ln) of the slope of each best-fit line (determined in step 4) along the...

  7. Analysis of experimental series of plutonium nitrate in aqueous solution and their correlation coefficients

    CERN Document Server

    Kilger, Robert; Stuke, Maik

    2016-01-01

    In this work we performed a detailed analysis on the calculation of 43 critical experiments from 6 experimental series all describing plutonium nitrate in aqueous solution contained in metal spheres. The underlying experimental data is taken from the handbook of the International Criticality Safety Benchmark Evaluation Project (ICSBEP) Working Group. We present our modeling assumptions which were derived from the interpretation of the experimental data and discuss the resulting sensitivity analysis. Although the experiments share some components, the derived correlation coefficients are for many cases statistically not significant. Comparing our findings for the correlation coefficients with available data from the DICE Database we find an agreement for the correlation coefficients due to nuclear data. We also compare our results for the correlation coefficients due to experimental uncertainty. Our findings indicate that for the reliable Determination of correlation coefficients a detailed study of the underl...

  8. Computer-assisted sperm analysis parameters in young fertile sperm donors and relationship with age.

    Science.gov (United States)

    Fréour, Thomas; Jean, Miguel; Mirallie, Sophie; Barriere, Paul

    2012-04-01

    Sperm parameter values have been shown to decline with age, according to conventional sperm analysis. However, the effect of age on sperm kinematic parameters has been rarely studied, especially in young fertile men. Here, we studied Computer-Assisted Sperm Analysis (CASA) parameters in a large cohort of men with proven fertility, in order to determine if there is a decline with age in this young fertile population. This retrospective analysis of CASA parameters was conducted on all donors included in the sperm donor programme in the Assisted Reproductive Techniques (ART) Centre of the University Hospital of Nantes between 2006 and 2009. Sperm concentration, motility, and kinetic parameters were recorded by a HTM-Ceros system and compared in 3 groups of sperm donors according to their age: donors were analyzed. Values for ALH, VCL, LIN, and STR significantly decreased with age. Sperm concentration, motile sperm proportion, and other kinetic parameters did not differ significantly among the groups. The use of CASA allowed the identification of ALH, VCL, LIN, and STR age-related decrease in young men with proven fertility.

  9. Analysis of measurement errors influence on experimental determination of mass and heat transfer coefficient

    International Nuclear Information System (INIS)

    The influence of temperature and concentration measurement errors on experimental determination of mass and heat transfer coefficients is analysed. Calculus model of coefficients and of measurement errors, the experimental data obtained on the water isotopic distillation plant and the results of determinations are presented. The experimental distillation column, with inner diameter of 108 mm, have been equipped with B7 structured packing on a height of 14 m. This column offers the possibility to measure vapour temperature and isotopic concentration in 12 locations. For error propagation analysis, the parameters measured for each packing bed, namely temperature and isotopic concentration of the vapour, were used. A relation for calculation of maximum error of experimental determinations of mass and heat transoprt coefficients is given. The experimental data emphasize the 'ending effects' and regions with bad thermal insulation. (author)

  10. Experimental modal analysis on damage of skeleton in brake of airplane

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    The relation between damage and modal parameters of skeleton has been discussed and analysed.Some significant results for detecting damage have been obtained by using experimental data of ωdi and ζi· Then, the modal experiments of four type of skeleton have been performed, the modal bifurcation phenomenon is discovered. It follows that this method for studying skeleton damage is a very promising method through theoretical and experimental analysis.

  11. Experimental and Numerical Analysis of a Scale-Model Horizontal Axis Hydrokinetic Turbine

    OpenAIRE

    Javaherchi, Teymour; Seydel, Joseph; Stelzenmuller, Nick; Aliseda, Alberto

    2014-01-01

    This paper presents an experimental/numerical study of a scale-model Horizontal Axis Hydrokinetic Turbine (HAHT). The model turbine is based on the DOE Reference Model 1 (DOE RM1), with a modified geometry to reproduce performance at the flume scale Reynolds numbers. These modifications were necessary to overcome the strong Reynolds number effect on the NACA–6 airfoil family used on the design, and therefore on the device performance in experimental analysis. The performance and wake structur...

  12. The incidence of cervical spondylosis decreases with aging in the elderly, and increases with aging in the young and adult population: a hospital-based clinical analysis

    Directory of Open Access Journals (Sweden)

    Wang C

    2016-01-01

    Full Text Available Chuanling Wang,1,* Fuming Tian,1,* Yingjun Zhou,2 Wenbo He,1 Zhiyou Cai1 1Department of Neurology, 2Physical Examination Center, Renmin Hospital, Hubei University of Medicine, Shiyan Renmin Hospital, Shiyan, Hubei Province, People’s Republic of China *These authors contributed equally to this work Background and purpose: Cervical spondylosis is well accepted as a common degenerative change in the cervical spine. Compelling evidence has shown that the incidence of cervical spondylosis increases with age. However, the relationship between age and the incidence of cervical spondylosis remains obscure. It is essential to note the relationship between age and the incidence of cervical spondylosis through more and more clinical data.Methods: In the case-controlled study reported here, retrospective clinical analysis of 1,276 cases of cervical spondylosis has been conducted. We analyzed the general clinical data, the relationship between age and the incidence of cervical spondylosis, and the relationship between age-related risk factors and the incidence of cervical spondylosis. A chi-square test was used to analyze the associations between different variables. Statistical significance was defined as a P-value of less than 0.05.Results: The imaging examination demonstrated the most prominent characteristic features of cervical spondylosis: bulge or herniation at C3-C4, C4-C5, and C5-C6. The incidence of cervical spondylosis increased with aging before age 50 years and decreased with aging after age 50 years, especially in the elderly after 60 years old. The occurrence rate of bulge or herniation at C3-C4, C4-C5, C5-C6, and C6-C7 increased with aging before age 50 years and decreased with aging after age 50 years, especially after 60 years. Moreover, the incidence of hyperosteogeny and spinal stenosis increased with aging before age 60 years and decreased with aging after age 60 years, although there was no obvious change in calcification. The age

  13. SPM analysis of cerebral blood flow changes related to age in patients with schizophrenia

    Energy Technology Data Exchange (ETDEWEB)

    Song, Ho Chun; Kim, Sung Wan; Lee, Byeong II; Min, Jung Joon; Bom, Hee Seung [Chonnam National University Medical School, Gwangju (Korea, Republic of)

    2007-07-01

    The goal of this study was to explore neural activities of schizophrenic patients related to current age including the age of onset and also we examined the correlation patterns between age and neural correlates. 21 patients with schizophrenia (female/male; 10/11, mean age; 36.1 11.2) participated in this study and all patients were evaluated by criteria of DSM-IV as a schizophrenia patient. Exclusion criteria included inability to give informed consent and a history of significant neurological illness. 99mTc-ECD brain perfusion SPECT images were obtained from 21 schizophrenic patients. Using SPM (statistical parametric mapping), all images were normalized to a SPECT template (MNI template) and then smoothed. We performed an ANCOVA analysis with current age (covariate variable) and the age of onset (nuisance variable). The correlation was analyzed into positive and negative patterns. Findings are reported as a Z scores with a significance threshold of p < 0.005 (uncorrected) and a minimum cluster size of 10. Significant difference was found between current age and premorbid age (p < 0.05). Cerebral regions that were positively correlated with current age were observed in the middle frontal gyrus and the superior frontal gyrus bilaterally, the left precentral gyrus (Brodmann's area; BA 9) and the right inferior frontal gyrus (BA 46). Also, in relation to negative correlations, there were many regions in the right posterior cingulate gyrus (BA 30) and the left cuneus (BA 30), middle temporal gyrus (BA 21) and superior temporal gyrus (BA 13, 39). Additionally, the occipital regions were found in the right cuneus (BA 18) including the right middle occipital gyrus (BA 18) and right lingual gyrus (BA 19). Age effect in schizophrenic patients was observed in the dorsolateral prefrontal cortex with positive correlation. We suggest that the dorsolateral prefrontal cortex activity which is important for cognitive task performance is related to an increase of patients

  14. Effect of thermal aging on the leak-before-break analysis of nuclear primary pipes

    Energy Technology Data Exchange (ETDEWEB)

    Lv, Xuming; Li, Shilei [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China); Wang, Xitao [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China); Collaborative Innovation Center of Steel Technology, University of Science and Technology Beijing, Beijing 100083 (China); Wang, Yanli [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China); Wang, Zhaoxi [CPI Nuclear Power Institute, 18 Xizhimen St., Beijing 100044 (China); Xue, Fei [Suzhou Nuclear Power Research Institute, Suzhou 215004 (China); Zhang, Hailong, E-mail: hlzhang@ustb.edu.cn [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China)

    2014-12-15

    Highlights: • Thermal aging embrittlement is considered in LBB assessment of nuclear pipe. • Effect of thermal aging on growth behavior of partial-through crack is not obvious. • Detectable leakage crack length of thermally aged material is slightly increased. • Critical crack length of thermally aged material is significantly reduced. • Ignorance of thermal aging produces less conservative LBB results. - Abstract: Three-dimensional finite element analysis (FEA) models were built for pipes with circumferential cracks and the effect of thermal aging embrittlement on the leak-before-break (LBB) behavior was analyzed according to the Level 2 and Level 3 safety assessments. The detectable leakage crack length obtained using the two-phase critical flow model and the critical crack length calculated by the J-integral stability assessment diagram method were carried out to assess the LBB behavior. The propagation behavior of partial-through circumferential cracks for both unaged and thermally aged materials was estimated by testing fatigue crack growth rate. The results show that the effect of thermal aging on detectable leakage crack length is not obvious, whereas the critical crack length after thermal aging significantly decreases due to degradation of fracture toughness. The increments of partial-through cracks are insignificant after 40 years of service. In the Level 2 and Level 3 safety assessments for nuclear piping, LBB is shown to have sufficient safety margins, while it is suggested to decrease in the case of thermal aging. This work demonstrates that less conservative LBB assessment results will be produced if thermal aging embrittlement in piping steels is not taken into consideration.

  15. Age and reemployment success after job loss: An integrative model and meta-analysis.

    Science.gov (United States)

    Wanberg, Connie R; Kanfer, Ruth; Hamann, Darla J; Zhang, Zhen

    2016-04-01

    Despite widespread popular concern about what it means to be over 40 and unemployed, little attention has been paid in the literature to clarifying the role of age within the job seeking experience. Extending theory, we propose mechanisms by which chronological age affects job search and reemployment outcomes after job loss. Through a meta-analysis and examination of 2 supplemental datasets, we examine 5 questions: (a) How strong is the relationship between age and reemployment speed? (b) Does age disadvantage individuals with respect to other reemployment outcomes? (c) Is the relationship between age and reemployment outcomes mediated by job search activities? (d) Are these relationships generalizable? and (e) Are these relationships linear or curvilinear? Our findings provide evidence for a negative relationship between age and reemployment status and speed across job search decade, world region, and unemployment rate, with the strength of the negative relationship becoming stronger over age 50. Job search self-efficacy and job search intensity partially mediate the relationship between age and both reemployment status and speed. (PsycINFO Database Record PMID:26011790

  16. Experimental spectra analysis in THM with the help of simulation based on Geant4 framework

    CERN Document Server

    Li, Chengbo; Zhou, Shuhua; Fu, Yuanyong; Zhou, Jing; Meng, Qiuying; Jiang, Zongjun; Wang, Xiaolian

    2014-01-01

    The Coulomb barrier and electron screening cause difficulties in directly measuring nuclear reaction cross sections of charged particles in astrophysical energies. The Trojan-horse method has been introduced to solve the difficulties as a powerful indirect tool. In order to understand experimental spectra better, Geant4 is employed to simulate the method for the first time. Validity and reliability of the simulation are examined by comparing the experimental data with simulated results. The Geant4 simulation can give useful information to understand the experimental spectra better in data analysis and is beneficial to the design for future related experiments.

  17. Velo and REXAN - Integrated Data Management and High Speed Analysis for Experimental Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Kleese van Dam, Kerstin; Carson, James P.; Corrigan, Abigail L.; Einstein, Daniel R.; Guillen, Zoe C.; Heath, Brandi S.; Kuprat, Andrew P.; Lanekoff, Ingela T.; Lansing, Carina S.; Laskin, Julia; Li, Dongsheng; Liu, Yan; Marshall, Matthew J.; Miller, Erin A.; Orr, Galya; Pinheiro da Silva, Paulo; Ryu, Seun; Szymanski, Craig J.; Thomas, Mathew

    2013-01-10

    The Chemical Imaging Initiative at the Pacific Northwest National Laboratory (PNNL) is creating a ‘Rapid Experimental Analysis’ (REXAN) Framework, based on the concept of reusable component libraries. REXAN allows developers to quickly compose and customize high throughput analysis pipelines for a range of experiments, as well as supporting the creation of multi-modal analysis pipelines. In addition, PNNL has coupled REXAN with its collaborative data management and analysis environment Velo to create an easy to use data management and analysis environments for experimental facilities. This paper will discuss the benefits of Velo and REXAN in the context of three examples: PNNL High Resolution Mass Spectrometry - reducing analysis times from hours to seconds, and enabling the analysis of much larger data samples (100KB to 40GB) at the same time · ALS X-Ray tomography - reducing analysis times of combined STXM and EM data collected at the ALS from weeks to minutes, decreasing manual work and increasing data volumes that can be analysed in a single step ·Multi-modal nano-scale analysis of STXM and TEM data - providing a semi automated process for particle detection The creation of REXAN has significantly shortened the development time for these analysis pipelines. The integration of Velo and REXAN has significantly increased the scientific productivity of the instruments and their users by creating easy to use data management and analysis environments with greatly reduced analysis times and improved analysis capabilities.

  18. (1) H NMR analysis of O-methyl-inositol isomers: a joint experimental and theoretical study.

    Science.gov (United States)

    De Almeida, Mauro V; Couri, Mara Rubia C; De Assis, João Vitor; Anconi, Cleber P A; Dos Santos, Hélio F; De Almeida, Wagner B

    2012-09-01

    Density functional theory (DFT) calculations of (1) H NMR chemical shifts for l-quebrachitol isomers were performed using the B3LYP functional employing the 6-31G(d,p) and 6-311 + G(2d,p) basis sets. The effect of the solvent on the B3LYP-calculated NMR spectrum was accounted for using the polarizable continuum model. Comparison is made with experimental (1) H NMR spectroscopic data, which shed light on the average uncertainty present in DFT calculations of chemical shifts and showed that the best match between experimental and theoretical B3LYP (1) H NMR profiles is a good strategy to assign the molecular structure present in the sample handled in the experimental measurements. Among four plausible O-methyl-inositol isomers, the l-quebrachitol 2a structure was unambiguously assigned based only on the comparative analysis of experimental and theoretical (1) H NMR chemical shift data. The B3LYP infrared (IR) spectrum was also calculated for the four isomers and compared with the experimental data, with analysis of the theoretical IR profiles corroborating assignment of the 2a structure. Therefore, it is confirmed in this study that a combined experimental/DFT spectroscopic investigation is a powerful tool in structural/conformational analysis studies. PMID:22865668

  19. Cluster analysis of polyphenol intake in a French middle-aged population (aged 35-64 years).

    Science.gov (United States)

    Julia, Chantal; Touvier, Mathilde; Lassale, Camille; Fezeu, Léopold; Galan, Pilar; Hercberg, Serge; Kesse-Guyot, Emmanuelle

    2016-01-01

    Polyphenols have been suggested as protective factors for a range of chronic diseases. However, studying the impact of individual polyphenols on health is hindered by the intrinsic inter-correlations among polyphenols. Alternatively, studying foods rich in specific polyphenols fails to grasp the ubiquity of these components. Studying overall dietary patterns would allow for a more comprehensive description of polyphenol intakes in the population. Our objective was to identify clusters of dietary polyphenol intakes in a French middle-aged population (35-64 years old). Participants from the primary prevention trial SUpplementation en VItamines et Minéraux AntioXydants (SU.VI.MAX) study were included in the present cross-sectional study (n 6092; 57·8 % females; mean age 48·7 (sd 6·4) years). The fifty most consumed individual dietary polyphenols were divided into energy-adjusted tertiles and introduced in a multiple correspondence analysis (MCA), leading to comprehensive factors of dietary polyphenol intakes. The identified factors discriminating polyphenol intakes were used in a hierarchical clustering procedure. Four clusters were identified, corresponding broadly to clustered preferences for their respective food sources. Cluster 1 was characterised by high intakes of tea polyphenols. Cluster 2 was characterised by high intakes of wine polyphenols. Cluster 3 was characterised by high intakes of flavanones and flavones, corresponding to high consumption of fruit and vegetables, and more broadly to a healthier diet. Cluster 4 was characterised by high intakes of hydroxycinnamic acids, but was also associated with alcohol consumption and smoking. Profiles of polyphenol intakes allowed for the identification of meaningful combinations of polyphenol intakes in the diet. PMID:27547391

  20. Nondeterministic method to analysis of the aging effects in PWR power plants components

    International Nuclear Information System (INIS)

    Highlights: • The aging process can to impact in the increase of failure probability of a system. • The study of the aging is important to guarantee the safety of an installation. • The methodology application is directed to the Containment Spray Injection System. • The impact of the aging effects portrays the need of the use of PSA techniques. - Abstract: This paper presents a contribution to the study of aging process of components in commercial plants of Pressurized Water Reactors (PWRs). The analysis is made through application of the Fault Trees Method, Monte Carlo Method and Fussell–Vesely Importance Measure. The approach of the study of aging in nuclear power plants, besides giving attention to the economic factors involved directly with the extent of their operational life, also provide significant data on security issues. In Brazil, for example, the Angra 1 Nuclear Power Plant invested $ 27 million to perform corrective actions in its network installation. This fact has generated an estimated operating life extension of Angra 1 in twenty years, offering great economy compared with building cost of a new plant and anterior decommissioning, if it had reached the time operating limit of forty years. The extension of the operating life of a nuclear power plant must be accompanied by a special attention to the components of the systems and their aging process. With the application of the methodology (aging analysis of the injection system of the containment spray) proposed in this paper, it can be seen the increase in the rate of component failure, due the aging process, generates the increase in the general unavailability of the system that containing these basic components. The final results obtained were as expected and may contribute to the maintenance policy, preventing premature aging process in Nuclear Plant Systems

  1. Development of a forensically useful age prediction method based on DNA methylation analysis.

    Science.gov (United States)

    Zbieć-Piekarska, Renata; Spólnicka, Magdalena; Kupiec, Tomasz; Parys-Proszek, Agnieszka; Makowska, Żanetta; Pałeczka, Anna; Kucharczyk, Krzysztof; Płoski, Rafał; Branicki, Wojciech

    2015-07-01

    Forensic DNA phenotyping needs to be supplemented with age prediction to become a relevant source of information on human appearance. Recent progress in analysis of the human methylome has enabled selection of multiple candidate loci showing linear correlation with chronological age. Practical application in forensic science depends on successful validation of these potential age predictors. In this study, eight DNA methylation candidate loci were analysed using convenient and reliable pyrosequencing technology. A total number of 41 CpG sites was investigated in 420 samples collected from men and women aged from 2 to 75 years. The study confirmed correlation of all the investigated markers with human age. The five most significantly correlated CpG sites in ELOVL2 on 6p24.2, C1orf132 on 1q32.2, TRIM59 on 3q25.33, KLF14 on 7q32.3 and FHL2 on 2q12.2 were chosen to build a prediction model. This restriction allowed the technical analysis to be simplified without lowering the prediction accuracy significantly. Model parameters for a discovery set of 300 samples were R(2)=0.94 and the standard error of the estimate=4.5 years. An independent set of 120 samples was used to test the model performance. Mean absolute deviation for this testing set was 3.9 years. The number of correct predictions ±5 years achieved a very high level of 86.7% in the age category 2-19 and gradually decreased to 50% in the age category 60-75. The prediction model was deterministic for individuals belonging to these two extreme age categories. The developed method was implemented in a freely available online age prediction calculator. PMID:26026729

  2. Experimental assessment of computer codes used for safety analysis of integral reactors

    Energy Technology Data Exchange (ETDEWEB)

    Falkov, A.A.; Kuul, V.S.; Samoilov, O.B. [OKB Mechanical Engineering, Nizhny Novgorod (Russian Federation)

    1995-09-01

    Peculiarities of integral reactor thermohydraulics in accidents are associated with presence of noncondensable gas in built-in pressurizer, absence of pumped ECCS, use of guard vessel for LOCAs localisation and passive RHRS through in-reactor HX`s. These features defined the main trends in experimental investigations and verification efforts for computer codes applied. The paper reviews briefly the performed experimental investigation of thermohydraulics of AST-500, VPBER600-type integral reactors. The characteristic of UROVEN/MB-3 code for LOCAs analysis in integral reactors and results of its verification are given. The assessment of RELAP5/mod3 applicability for accident analysis in integral reactor is presented.

  3. Theoretical analysis and experimental research on port/starboard discrimination in towed line array

    Institute of Scientific and Technical Information of China (English)

    DU Xuanmin; ZHU Daizhu; ZHAO Rongrong; YAO Lan

    2001-01-01

    The theoretical analysis and experimental research on Port/Starboard (P/S) discrimination in towed line array are proposed. Two methods resolving the P/S ambiguity with hydrophone triplets are introduced. By processing experimental data, the theoretical analysis is verified. The processing algorithm is extended to broadband signal. The research results show that the method based on optimum beamforming with triplets can be used to remove the port/starboard ambiguity. Also because of the simplicity of the method, it is expected to be implemented in practical towed line array sonar.

  4. Age estimation in forensic sciences: Application of combined aspartic acid racemization and radiocarbon analysis

    Energy Technology Data Exchange (ETDEWEB)

    Alkass, K; Buchholz, B A; Ohtani, S; Yamamoto, T; Druid, H; Spalding, S L

    2009-11-02

    Age determination of unknown human bodies is important in the setting of a crime investigation or a mass disaster, since the age at death, birth date and year of death, as well as gender, can guide investigators to the correct identity among a large number of possible matches. Traditional morphological methods used by anthropologists to determine age are often imprecise, whereas chemical analysis of tooth dentin, such as aspartic acid racemization has shown reproducible and more precise results. In this paper we analyze teeth from Swedish individuals using both aspartic acid racemization and radiocarbon methodologies. The rationale behind using radiocarbon analysis is that above-ground testing of nuclear weapons during the cold war (1955-1963) caused an extreme increase in global levels of carbon-14 ({sup 14}C) which have been carefully recorded over time. Forty-four teeth from 41 individuals were analyzed using aspartic acid racemization analysis of tooth crown dentin or radiocarbon analysis of enamel and ten of these were split and subjected to both radiocarbon and racemization analysis. Combined analysis showed that the two methods correlated well (R2=0.66, p < 0.05). Radiocarbon analysis showed an excellent precision with an overall absolute error of 0.6 {+-} 04 years. Aspartic acid racemization also showed a good precision with an overall absolute error of 5.4 {+-} 4.2 years. Whereas radiocarbon analysis gives an estimated year of birth, racemization analysis indicates the chronological age of the individual at the time of death. We show how these methods in combination can also assist in the estimation of date of death of an unidentified victim. This strategy can be of significant assistance in forensic casework involving dead victim identification.

  5. Insulation Diagnosis of Service Aged XLPE Power Cables Using Statistical Analysis and Fuzzy Inference

    Institute of Scientific and Technical Information of China (English)

    LIU Fei; JIANG Pingkai; LEI Qingquan; ZHANG Li; SU Wenqun

    2013-01-01

    Cables that have been in service for over 20 years in Shanghai,a city with abundant surface water,failed more frequently and induced different cable accidents.This necessitates researches on the insulation aging state of cables working in special circumstances.We performed multi-parameter tests with samples from about 300 cable lines in Shanghai.The tests included water tree investigation,tensile test,dielectric spectroscopy test,thermogravimetric analysis (TGA),fourier transform infrared spectroscopy (FTIR),and electrical aging test.Then,we carried out regression analysis between every two test parameters.Moreover,through two-sample t-Test and analysis of variance (ANOVA) of each test parameter,we analyzed the influences of cable-laying method and sampling section on the degradation of cable insulation respectively.Furthermore,the test parameters which have strong correlation in the regression analysis or significant differences in the t-Test or ANOVA analysis were determined to be the ones identifying the XLPE cable insulation aging state.The thresholds for distinguishing insulation aging states had been also obtained with the aid of statistical analysis and fuzzy clustering.Based on the fuzzy inference,we established a cable insulation aging diagnosis model using the intensity transfer method.The results of regression analysis indicate that the degradation of cable insulation accelerates as the degree of in-service aging increases.This validates the rule that the increase of microscopic imperfections in solid material enhances the dielectric breakdown strength.The results of the two-sample t-Test and the ANOVA indicate that the direct-buried cables are more sensitive to insulation degradation than duct cables.This confirms that the tensile strength and breakdown strength are reliable functional parameters in cable insulation evaluations.A case study further indicates that the proposed diagnosis model based on the fuzzy inference can reflect the comprehensive

  6. Root dentine transparency: age determination of human teeth using computerized densitometric analysis.

    Science.gov (United States)

    Drusini, A; Calliari, I; Volpe, A

    1991-05-01

    Root dentine transparency (RDT) was used to estimate the ages of human subjects from 152 intact teeth. Teeth were from 134 subjects, both historical and recent, of known age and sex. The aims of this work are 1) to compare two methods of using RDT to estimate age; 2) to test the applicability of the regression formulae for estimating age obtained from a recent sample on an historical sample; and 3) to estimate the suitability of RDT to determine age at death of 100-year-old skeletons. RDT was measured by two techniques: 1) computerized densitometric analysis and 2) vernier caliper. Age estimations based on computerized densitometric analysis were no more accurate than were those determined by caliper measurement; both give a predictive success of +/- 5 years in about 45-48% of cases for premolars. The television-based digitization system has some disadvantages: It is expensive, not portable, and requires some training to use. However, it furnishes a more standardized method, a rapid graphic illustration of the results, and an immediate storage of statistical information for future use. PMID:1853940

  7. PIXE analysis of Middle Age objects using 68 MeV protons

    Energy Technology Data Exchange (ETDEWEB)

    Denker, A. E-mail: denker@hmi.de; Blaich, M.C

    2002-04-01

    PIXE with high-energy protons is particularly suited for the analysis of thick objects, especially for heavy elements behind layers that may be several mm thick. A typical application, namely the analysis of brooches from the early Middle Ages, is presented. These objects were covered with a plastic varnish of several mm thickness to prevent further corrosion. Now an analysis of the elements in the brooches was requested. The protective layer could not be removed for any standard analysis without destroying the objects. Therefore high-energy PIXE was used. The measurements and the results are presented.

  8. Cardiac autonomic changes in middle-aged women: identification based on principal component analysis.

    Science.gov (United States)

    Trevizani, Gabriela A; Nasario-Junior, Olivassé; Benchimol-Barbosa, Paulo R; Silva, Lilian P; Nadal, Jurandir

    2016-07-01

    The purpose of this study was to investigate the application of the principal component analysis (PCA) technique on power spectral density function (PSD) of consecutive normal RR intervals (iRR) aiming at assessing its ability to discriminate healthy women according to age groups: young group (20-25 year-old) and middle-aged group (40-60 year-old). Thirty healthy and non-smoking female volunteers were investigated (13 young [mean ± SD (median): 22·8 ± 0·9 years (23·0)] and 17 Middle-aged [51·7 ± 5·3 years (50·0)]). The iRR sequence was collected during ten minutes, breathing spontaneously, in supine position and in the morning, using a heart rate monitor. After selecting an iRR segment (5 min) with the smallest variance, an auto regressive model was used to estimate the PSD. Five principal component coefficients, extracted from PSD signals, were retained for analysis according to the Mahalanobis distance classifier. A threshold established by logistic regression allowed the separation of the groups with 100% specificity, 83·2% sensitivity and 93·3% total accuracy. The PCA appropriately classified two groups of women in relation to age (young and Middle-aged) based on PSD analysis of consecutive normal RR intervals. PMID:25532598

  9. 230Th/U ages Supporting Hanford Site‐Wide Probabilistic Seismic Hazard Analysis

    Science.gov (United States)

    Paces, James B.

    2014-01-01

    This product represents a USGS Administrative Report that discusses samples and methods used to conduct uranium-series isotope analyses and resulting ages and initial 234U/238U activity ratios of pedogenic cements developed in several different surfaces in the Hanford area middle to late Pleistocene. Samples were collected and dated to provide calibration of soil development in surface deposits that are being used in the Hanford Site-Wide probabilistic seismic hazard analysis conducted by AMEC. The report includes description of sample locations and physical characteristics, sample preparation, chemical processing and mass spectrometry, analytical results, and calculated ages for individual sites. Ages of innermost rinds on a number of samples from five sites in eastern Washington are consistent with a range of minimum depositional ages from 17 ka for cataclysmic flood deposits to greater than 500 ka for alluvium at several sites.

  10. 230Th/U ages Supporting Hanford Site-Wide Probabilistic Seismic Hazard Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Paces, James B. [U.S. Geological Survey

    2014-08-31

    This product represents a USGS Administrative Report that discusses samples and methods used to conduct uranium-series isotope analyses and resulting ages and initial 234U/238U activity ratios of pedogenic cements developed in several different surfaces in the Hanford area middle to late Pleistocene. Samples were collected and dated to provide calibration of soil development in surface deposits that are being used in the Hanford Site-Wide probabilistic seismic hazard analysis conducted by AMEC. The report includes description of sample locations and physical characteristics, sample preparation, chemical processing and mass spectrometry, analytical results, and calculated ages for individual sites. Ages of innermost rinds on a number of samples from five sites in eastern Washington are consistent with a range of minimum depositional ages from 17 ka for cataclysmic flood deposits to greater than 500 ka for alluvium at several sites.

  11. Experimental evidence of ageing and slow restoration of the weak-contact configuration in tilted 3D granular packings

    Science.gov (United States)

    Kiesgen de Richter, S.; Zaitsev, V. Yu; Richard, P.; Delannay, R.; Le Caër, G.; Tournat, V.

    2010-11-01

    Granular packings slowly driven towards their instability threshold are studied using a digital imaging technique as well as a nonlinear acoustic method. The former method allows us to study grain rearrangements on the surface during the tilting and the latter enables us to selectively probe the modifications of the weak-contact fraction in the material bulk. Gradual ageing of both the surface activity and the weak-contact reconfigurations is observed as a result of repeated tilt cycles up to a given angle smaller than the angle of avalanche. For an aged configuration reached after several consecutive tilt cycles, abrupt resumption of the on-surface activity and of the weak-contact rearrangements occurs when the packing is subsequently inclined beyond the previous maximal tilting angle. This behavior is compared with literature results from numerical simulations of inclined 2D packings. It is also found that the aged weak-contact configurations exhibit spontaneous restoration towards the initial state if the packing remains at rest for tens of minutes. When the packing is titled forth and back between zero and near-critical angles, instead of ageing, the weak-contact configuration exhibits 'internal weak-contact avalanches' in the vicinity of both the near-critical and zero angles. By contrast, the stronger-contact skeleton remains stable.

  12. Experimental and finite element analysis of strains induced by axial tibial compression in young-adult and old female C57Bl/6 mice

    OpenAIRE

    Patel, Tarpit K.; Brodt, Michael D.; Silva, Matthew J.

    2013-01-01

    Axial compression of the mouse tibia is used to study strain-adaptive bone (re)modeling. In some studies, comparisons between mice of different ages are of interest. We characterized the tibial deformation and force–strain relationships in female C57Bl/6 mice at 5-, 12- and 22-months age. A three-gauge experimental method was used to determine the strain distribution at the mid-diaphysis, while specimen-specific finite element analysis was used to examine strain distribution along the tibial ...

  13. Evaluating the effect of ageing on interference resolution with time-varying complex networks analysis

    Directory of Open Access Journals (Sweden)

    Pedro eAriza

    2015-05-01

    Full Text Available In this study we used graph theory analysis to investigate age-related reorganization of functional networks during the active maintenance of information that is interrupted by external interference. Additionally, we sought to investigate network differences before and after averaging network parameters between both maintenance and interference windows. We compared young and older adults by measuring their magnetoencephalographic recordings during an interference-based working memory task restricted to successful recognitions. Data analysis focused on the topology/temporal evolution of functional networks during both the maintenance and interference windows. We observed that: a Older adults require higher synchronization between cortical brain sites in order to achieve a successful recognition, b The main differences between age groups arise during the interference window c Older adults show reduced ability to reorganize network topology when interference is introduced, and d Averaging network parameters leads to a loss of sensitivity to detect age differences.

  14. Evaluating the effect of aging on interference resolution with time-varying complex networks analysis

    Science.gov (United States)

    Ariza, Pedro; Solesio-Jofre, Elena; Martínez, Johann H.; Pineda-Pardo, José A.; Niso, Guiomar; Maestú, Fernando; Buldú, Javier M.

    2015-01-01

    In this study we used graph theory analysis to investigate age-related reorganization of functional networks during the active maintenance of information that is interrupted by external interference. Additionally, we sought to investigate network differences before and after averaging network parameters between both maintenance and interference windows. We compared young and older adults by measuring their magnetoencephalographic recordings during an interference-based working memory task restricted to successful recognitions. Data analysis focused on the topology/temporal evolution of functional networks during both the maintenance and interference windows. We observed that: (a) Older adults require higher synchronization between cortical brain sites in order to achieve a successful recognition, (b) The main differences between age groups arise during the interference window, (c) Older adults show reduced ability to reorganize network topology when interference is introduced, and (d) Averaging network parameters leads to a loss of sensitivity to detect age differences. PMID:26029079

  15. Patterns of cognitive performance in healthy ageing in Northern Portugal: a cross-sectional analysis.

    Directory of Open Access Journals (Sweden)

    Ana Cristina Paulo

    Full Text Available BACKGROUND: The Minho Integrative Neuroscience Database (MIND-Ageing project aims to identify predictors of healthy cognitive ageing, including socio-demographic factors. In this exploratory analysis we sought to establish baseline cohorts for longitudinal assessment of age-related changes in cognition. METHODS: The population sample (472 individuals was strictly a convenient one, but similar to the Portuguese population in the age profile. Participants older than 55 years of age were included if they did not present defined disabling pathologies or dementia. A standardized clinical interview was conducted to assess medical history and a battery of neuropsychological tests was administered to characterize global cognition (Mini Mental State Examination, memory and executive functions (Selective Reminding Test; Stroop Color and Word Test; and Block Design subtest of the Wechsler Adult Intelligence Scale. Cross-sectional analysis of the neuropsychological performance with individual characteristics such as age, gender, educational level and setting (retirement home, senior university, day care center or community, allowed the establishment of baseline clusters for subsequent longitudinal studies. RESULTS: Based on different socio-demographic characteristics, four main clusters that group distinctive patterns of cognitive performance were identified. The type of institution where the elders were sampled from, together with the level of formal education, were the major hierarchal factors for individual distribution in the four clusters. Of notice, education seems to delay the cognitive decline that is associated with age in all clusters. CONCLUSIONS: Social-inclusion/engagement and education seem to have a protective effect on mental ageing, although this effect may not be effective in the eldest elders.

  16. Success Rate of Inseminations Dependent on Maternal Age? An Analysis of 4246 Insemination Cycles

    OpenAIRE

    Schorsch, M.; Gomez, R.; Hahn, T.; Hoelscher-Obermaier, J.; Seufert, R.; Skala, C.

    2013-01-01

    Intrauterine insemination (IUI) has latterly become less important in reproductive medicine. The aim of this retrospective analysis was to identify and evaluate the success rates of repeated insemination cycles in women of different ages. All women who underwent intrauterine insemination in the Wiesbaden Fertility Clinic between 1998 and 2010 were included in the analysis. Additional inclusion criteria were: not more than 45 years old, previous FSH stimulation and slight to ...

  17. Artificial Neural Network Analysis of Sierpinski Gasket Fractal Antenna: A Low Cost Alternative to Experimentation

    Directory of Open Access Journals (Sweden)

    Balwinder S. Dhaliwal

    2013-01-01

    Full Text Available Artificial neural networks due to their general-purpose nature are used to solve problems in diverse fields. Artificial neural networks (ANNs are very useful for fractal antenna analysis as the development of mathematical models of such antennas is very difficult due to complex shapes and geometries. As such empirical approach doing experiments is costly and time consuming, in this paper, application of artificial neural networks analysis is presented taking the Sierpinski gasket fractal antenna as an example. The performance of three different types of networks is evaluated and the best network for this type of applications has been proposed. The comparison of ANN results with experimental results validates that this technique is an alternative to experimental analysis. This low cost method of antenna analysis will be very useful to understand various aspects of fractal antennas.

  18. Digital Natives, Digital Immigrants: An Analysis of Age and ICT Competency in Teacher Education

    Science.gov (United States)

    Guo, Ruth Xiaoqing; Dobson, Teresa; Petrina, Stephen

    2008-01-01

    This article examines the intersection of age and ICT (information and communication technology) competency and critiques the "digital natives versus digital immigrants" argument proposed by Prensky (2001a, 2001b). Quantitative analysis was applied to a statistical data set collected in the context of a study with over 2,000 pre-service teachers…

  19. Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index

    DEFF Research Database (Denmark)

    Minster, Ryan L; Sanders, Jason L; Singh, Jatinder;

    2015-01-01

    BACKGROUND: The Healthy Aging Index (HAI) is a tool for measuring the extent of health and disease across multiple systems. METHODS: We conducted a genome-wide association study and a genome-wide linkage analysis to map quantitative trait loci associated with the HAI and a modified HAI weighted...

  20. Sporting Bodies, Ageing, Narrative Mapping and Young Team Athletes: An Analysis of Possible Selves

    Science.gov (United States)

    Phoenix, Cassandra; Sparkes, Andrew C.

    2007-01-01

    Drawing on life history data generated from interviews with young athletes at an English university, this paper explores the narrative maps provided to them by older team members and the ways in which these influence perceptions of self-ageing. Three possible selves associated with mid-life emerged from the analysis for detailed focus. These are…

  1. Quench front progression in a superheated porous medium: experimental analysis and model development

    International Nuclear Information System (INIS)

    In case of severe accident in a nuclear reactor, the fuel rods may be highly damaged and oxidized and finally collapse to form a debris bed. Removal of decay heat from a debris bed is a challenging issue because of the difficulty for water to flow inside. Currently, IRSN has started experimental program PEARL with two experimental facilities PRELUDE and PEARL, to investigate the reflood process at high temperature, for various particle sizes. On the basis of PRELUDE experimental results, the thermal hydraulic features of the quench front have been analysed and the intensity of heat transfers was estimated. From a selection of experimental results, a reflooding model was improved and validated. The model is implemented in the code ICARE-CATHARE developed by IRSN which is used for severe accident reactor analysis. (author)

  2. Mechanism Analysis and Experimental Validation of Employing Superconducting Magnetic Energy Storage to Enhance Power System Stability

    OpenAIRE

    Xiaohan Shi; Shaorong Wang; Wei Yao; Asad Waqar; Wenping Zuo; Yuejin Tang

    2015-01-01

    This paper investigates the mechanism analysis and the experimental validation of employing superconducting magnetic energy storage (SMES) to enhance power system stability. The models of the SMES device and the single-machine infinite-bus (SMIB) system with SMES are deduced. Based on the model of the SMIB system with SMES, the action mechanism of SMES on a generator is analyzed. The analysis takes the impact of SMES location and the system operating point into consideration, as well. Based ...

  3. Experimental display of Fourier analysis through the optical physics and its didatical utilization

    International Nuclear Information System (INIS)

    The properties of Fourier analysis through physical optics are displayed experimentally. Within physical optics topics that illustrate didactically Fourier analysis, a subject usually considered purely mathematical are selected. The most important properties of Fourier transform and their utilization in cleaning up images through spatial filtering are presented, in this way the properties of convolution to analyse image formation and characterize some diffraction patterns are also used. (Author)

  4. Age estimation in the living: Transition analysis on developing third molars.

    Science.gov (United States)

    Tangmose, Sara; Thevissen, Patrick; Lynnerup, Niels; Willems, Guy; Boldsen, Jesper

    2015-12-01

    A radiographic assessment of third molar development is essential for differentiating between juveniles and adolescents in forensic age estimations. As the developmental stages of third molars are highly correlated, age estimates based on a combination of a full set of third molar scores are statistically complicated. Transition analysis (TA) is a statistical method developed for estimating age at death in skeletons, which combines several correlated developmental traits into one age estimate including a 95% prediction interval. The aim of this study was to evaluate the performance of TA in the living on a full set of third molar scores. A cross sectional sample of 854 panoramic radiographs, homogenously distributed by sex and age (15.0-24.0 years), were randomly split in two; a reference sample for obtaining age estimates including a 95% prediction interval according to TA; and a validation sample to test the age estimates against actual age. The mean inaccuracy of the age estimates was 1.82 years (±1.35) in males and 1.81 years (±1.44) in females. The mean bias was 0.55 years (±2.20) in males and 0.31 years (±2.30) in females. Of the actual ages, 93.7% of the males and 95.9% of the females (validation sample) fell within the 95% prediction interval. Moreover, at a sensitivity and specificity of 0.824 and 0.937 in males and 0.814 and 0.827 in females, TA performs well in differentiating between being a minor as opposed to an adult. Although accuracy does not outperform other methods, TA provides unbiased age estimates which minimize the risk of wrongly estimating minors as adults. Furthermore, when corrected ad hoc, TA produces appropriate prediction intervals. As TA allows expansion with additional traits, i.e. stages of development of the left hand-wrist and the clavicle, it has a great potential for future more accurate and reproducible age estimates, including an estimated probability of having attained the legal age limit of 18 years.

  5. Dynamic Analysis of Rotating Shaft Subjects to Slant Crack with Experimentation and ANSYS Validation

    Directory of Open Access Journals (Sweden)

    Rushikesh V. Dhokate

    2014-09-01

    Full Text Available The paper contents the dynamic study of rotating shaft with slant crack on surface of shaft. Slant cracks are prepared artificially on surface of shaft with material EN8. In this study, crack location taken on shaft 150 mm from motor side and also for effective study healthy shaft of EN8 material is taken. Experimental results are taken with the help of FFT analyzer. Analysis is carried out from these results and finally these results are validated in FEA software i. e. ANSYS14 software. These validated results with graphs are explained in this paper. The experimentation is also done on healthy shaft of EN8 material for analysis. This paper mainly focused on validation of experimental results with ANSYS software.

  6. Creep experimental test and analysis of high-performance concrete in bridge

    Institute of Scientific and Technical Information of China (English)

    陈志华; 袁健

    2008-01-01

    Factors that have effect on concrete creep include mixture composition,curing conditions,ambient exposure conditions,and element geometry.Considering concrete mixtures influence and in order to improve the prediction of prestress loss in important structures,an experimental test under laboratory conditions was carried out to investigate compression creep of two high performance concrete mixtures used for prestressed members in one bridge.Based on the experimental results,a power exponent function of creep degree for structural numerical analysis was used to model the creep degree of two HPCs,and two series of parameters of this function for two HPCs were calculated with evolution program optimum method.The experimental data was compared with CEB-FIP 90 and ACI 209(92) models,and the two code models both overestimated creep degrees of the two HPCs.So it is recommended that the power exponent function should be used in this bridge structure analysis.

  7. An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging.

    Directory of Open Access Journals (Sweden)

    Tian Yuan

    2015-02-01

    Full Text Available Recent studies have demonstrated that the DNA methylome changes with age. This epigenetic drift may have deep implications for cellular differentiation and disease development. However, it remains unclear how much of this drift is functional or caused by underlying changes in cell subtype composition. Moreover, no study has yet comprehensively explored epigenetic drift at different genomic length scales and in relation to regulatory elements. Here we conduct an in-depth analysis of epigenetic drift in blood tissue. We demonstrate that most of the age-associated drift is independent of the increase in the granulocyte to lymphocyte ratio that accompanies aging and that enrichment of age-hypermethylated CpG islands increases upon adjustment for cellular composition. We further find that drift has only a minimal impact on in-cis gene expression, acting primarily to stabilize pre-existing baseline expression levels. By studying epigenetic drift at different genomic length scales, we demonstrate the existence of mega-base scale age-associated hypomethylated blocks, covering approximately 14% of the human genome, and which exhibit preferential hypomethylation in age-matched cancer tissue. Importantly, we demonstrate the feasibility of integrating Illumina 450k DNA methylation with ENCODE data to identify transcription factors with key roles in cellular development and aging. Specifically, we identify REST and regulatory factors of the histone methyltransferase MLL complex, whose function may be disrupted in aging. In summary, most of the epigenetic drift seen in blood is independent of changes in blood cell type composition, and exhibits patterns at different genomic length scales reminiscent of those seen in cancer. Integration of Illumina 450k with appropriate ENCODE data may represent a fruitful approach to identify transcription factors with key roles in aging and disease.

  8. Alendronate Can Improve Bone Alterations in Experimental Diabetes by Preventing Antiosteogenic, Antichondrogenic, and Proadipocytic Effects of AGEs on Bone Marrow Progenitor Cells

    Directory of Open Access Journals (Sweden)

    Sara Rocío Chuguransky

    2016-01-01

    Full Text Available Bisphosphonates such as alendronate are antiosteoporotic drugs that inhibit the activity of bone-resorbing osteoclasts and secondarily promote osteoblastic function. Diabetes increases bone-matrix-associated advanced glycation end products (AGEs that impair bone marrow progenitor cell (BMPC osteogenic potential and decrease bone quality. Here we investigated the in vitro effect of alendronate and/or AGEs on the osteoblastogenic, adipogenic, and chondrogenic potential of BMPC isolated from nondiabetic untreated rats. We also evaluated the in vivo effect of alendronate (administered orally to rats with insulin-deficient Diabetes on long-bone microarchitecture and BMPC multilineage potential. In vitro, the osteogenesis (Runx2, alkaline phosphatase, type 1 collagen, and mineralization and chondrogenesis (glycosaminoglycan production of BMPC were both decreased by AGEs, while coincubation with alendronate prevented these effects. The adipogenesis of BMPC (PPARγ, intracellular triglycerides, and lipase was increased by AGEs, and this was prevented by coincubation with alendronate. In vivo, experimental Diabetes (a decreased femoral trabecular bone area, osteocyte density, and osteoclastic TRAP activity; (b increased bone marrow adiposity; and (c deregulated BMPC phenotypic potential (increasing adipogenesis and decreasing osteogenesis and chondrogenesis. Orally administered alendronate prevented all these Diabetes-induced effects on bone. Thus, alendronate could improve bone alterations in diabetic rats by preventing the antiosteogenic, antichondrogenic, and proadipocytic effects of AGEs on BMPC.

  9. Experimental and numerical analysis of the steady-state behaviour of a beam system with impact

    NARCIS (Netherlands)

    Vorst, E.L.B. van de; Heertjes, M.F.; Campen, D.H. van; Kraker, A. de; Fey, R.H.B.

    1998-01-01

    In this paper the steady state behaviour of a beam system with a periodically moving support and an elastic stop is analysed both numerically and experimentally. In the numerical analysis a continuous model for the elastic stop is used based on the contact force law of Hertz. The beam is modelled us

  10. The Etymology of Basic Concepts in the Experimental Analysis of Behavior

    Science.gov (United States)

    Dinsmoor, James A.

    2004-01-01

    The origins of many of the basic concepts used in the experimental analysis of behavior can be traced to Pavlov's (1927/1960) discussion of unconditional and conditional reflexes in the dog, but often with substantial changes in meaning (e.g., stimulus, response, and reinforcement). Other terms were added by Skinner (1938/1991) to describe his…

  11. Wheeler's delayed-choice thought experiment: Experimental realization and theoretical analysis

    OpenAIRE

    Jacques, Vincent; Wu, E; Grosshans, Frédéric; Treussart, François; Aspect, Alain; Grangier, Philippe; Roch, Jean-François

    2007-01-01

    Wheeler has strikingly illustrated the wave-particle duality by the delayed-choice thought experiment, in which the configuration of a 2-path interferometer is chosen after a single-photon light-pulsed has entered it. We present a quantitative theoretical analysis of an experimental realization of Wheeler's proposal.

  12. Application of ABCD Formalism in Theoretical and Experimental Analysis of Actively Modelocked Fiber Laser

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Time domain ABCD matrix formalism is a useful model for analyzing the characteristics of actively modelocked fiber laser. Based on this model and given more consideration on the influences of optical fiber dispersion and optical fiber nonlinearity, the laser characteristic of actively modelocked fiber laser is analyzed, and the comparision of the theoretical analysis results with experimental ones is given.

  13. Proteomic analysis reveals age-related changes in tendon matrix composition, with age- and injury-specific matrix fragmentation.

    Science.gov (United States)

    Peffers, Mandy J; Thorpe, Chavaunne T; Collins, John A; Eong, Robin; Wei, Timothy K J; Screen, Hazel R C; Clegg, Peter D

    2014-09-12

    Energy storing tendons, such as the human Achilles and equine superficial digital flexor tendon (SDFT), are highly prone to injury, the incidence of which increases with aging. The cellular and molecular mechanisms that result in increased injury in aged tendons are not well established but are thought to result in altered matrix turnover. However, little attempt has been made to fully characterize the tendon proteome nor determine how the abundance of specific tendon proteins changes with aging and/or injury. The aim of this study was, therefore, to assess the protein profile of normal SDFTs from young and old horses using label-free relative quantification to identify differentially abundant proteins and peptide fragments between age groups. The protein profile of injured SDFTs from young and old horses was also assessed. The results demonstrate distinct proteomic profiles in young and old tendon, with alterations in the levels of proteins involved in matrix organization and regulation of cell tension. Furthermore, we identified several new peptide fragments (neopeptides) present in aged tendons, suggesting that there are age-specific cleavage patterns within the SDFT. Proteomic profile also differed between young and old injured tendon, with a greater number of neopeptides identified in young injured tendon. This study has increased the knowledge of molecular events associated with tendon aging and injury, suggesting that maintenance and repair of tendon tissue may be reduced in aged individuals and may help to explain why the risk of injury increases with aging. PMID:25077967

  14. Educational expansion and the education gradient in health: A hierarchical age-period-cohort analysis.

    Science.gov (United States)

    Delaruelle, Katrijn; Buffel, Veerle; Bracke, Piet

    2015-11-01

    Researchers have recently been investigating the temporal variation in the educational gradient in health. While there is abundant literature concerning age trajectories, theoretical knowledge about cohort differences is relatively limited. Therefore, in analogy with the life course perspective, we introduce two contrasting cohort-specific hypotheses. The diminishing health returns hypothesis predicts a decrease in educational disparities in health across cohorts. By contrast, the cohort accretion hypothesis suggests that the education-health gap will be more pronounced among younger cohorts. To shed light on this, we perform a hierarchical age-period-cohort analysis (HAPC), using data from a subsample of individuals between 25 and 85 years of age (N = 232,573) from 32 countries in the European Social Survey (six waves: 2002-2012). The analysis leads to three important conclusions. First, we observe a widening health gap between different educational levels over the life course. Second, we find that these educational differences in the age trajectories of health seem to strengthen with each successive birth cohort. However, the two age-related effects disappear when we control for employment status, household income, and family characteristics. Last, when adjusting for these mediators, we reveal evidence to support the diminishing health returns hypothesis, implying that it is primarily the direct association between education and health that decreases across cohorts. This finding raises concerns about potential barriers to education being a vehicle for empowerment and the promotion of health.

  15. Evidence of aging effects on certain safety-related components: summary and analysis

    International Nuclear Information System (INIS)

    In response to interest shown by the Nuclear Energy Agency (NEA), Principal Working Group I (PWG- 1) of the Committee on the Safety of Nuclear Installations (CSNI) conducted a generic study on the effects of aging of active components in nuclear power plants. Representatives from France, Sweden, Finland, Japan, the United States, and the United Kingdom participated in the study by submitting reports documenting aging studies performed in their countries. This report consists of summaries of those reports, along with a comparison of the various statistical analysis methods used in the studies. The studies indicate that with some exceptions, active components generally do not present a significant aging problem in nuclear power plants. Design criteria and effective preventative maintenance programs, including timely replacement of components, are effective in mitigating potential aging problems. However, aging studies (such as qualitative and statistical analyses of failure modes and maintenance data) are an important part of efforts to identify and solve potential aging problems. Solving these problems typically includes such strategies as replacing suspect components with improved components, and implementing improved maintenance programs

  16. Deep Proteome Analysis Identifies Age-Related Processes in C. elegans.

    Science.gov (United States)

    Narayan, Vikram; Ly, Tony; Pourkarimi, Ehsan; Murillo, Alejandro Brenes; Gartner, Anton; Lamond, Angus I; Kenyon, Cynthia

    2016-08-01

    Effective network analysis of protein data requires high-quality proteomic datasets. Here, we report a near doubling in coverage of the C. elegans adult proteome, identifying >11,000 proteins in total with ∼9,400 proteins reproducibly detected in three biological replicates. Using quantitative mass spectrometry, we identify proteins whose abundances vary with age, revealing a concerted downregulation of proteins involved in specific metabolic pathways and upregulation of cellular stress responses with advancing age. Among these are ∼30 peroxisomal proteins, including the PRX-5/PEX5 import protein. Functional experiments confirm that protein import into the peroxisome is compromised in vivo in old animals. We also studied the behavior of the set of age-variant proteins in chronologically age-matched, long-lived daf-2 insulin/IGF-1-pathway mutants. Unexpectedly, the levels of many of these age-variant proteins did not scale with extended lifespan. This indicates that, despite their youthful appearance and extended lifespans, not all aspects of aging are reset in these long-lived mutants. PMID:27453442

  17. Age-Related Impairment of Quality of Joint Motion in Vibroarthrographic Signal Analysis

    Directory of Open Access Journals (Sweden)

    Dawid Bączkowicz

    2015-01-01

    Full Text Available Aging is associated with degenerative changes in articular surfaces leading to quantitative and qualitative impairment of joint motion. Therefore, the aim of this study is to evaluate an age-related quality of the patellofemoral joint (PFJ motion in the vibroarthrographic (VAG signal analysis. Two hundred and twenty individuals were enrolled in this study and divided into five groups according to age. The VAG signals were collected during flexion/extension knee motion using an acceleration sensor and described using four parameters (VMS, P1, P2, and H. We observed that values of parameters VMS, P1, and P2 increase in accordance with the age, but H level decreases. The most significant differences were achieved between the youngest and the oldest participants’ groups. Moreover, we show that parameters VMS, P1, and P2 positively correlate with age, contrary to negatively associated H parameter. Our results suggest that the impairment of joint motion is a result of age-related osteoarticular degenerative changes.

  18. The prevalence of lacunar infarct decreases with aging in the elderly: a case-controlled analysis

    Directory of Open Access Journals (Sweden)

    Cai Z

    2016-05-01

    Full Text Available Zhiyou Cai,1 Wenbo He,1 Chuan-yong Peng,2 Jin Zhou,2 Qi-lan Xu,2 Zong-shan Wu2 1Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan Renmin Hospital, Shiyan, Hubei Province, 2The Examination Center of Magnetic Resonance Imaging, the Lu’an Affiliated Hospital of Anhui Medical University, Lu’an People’s Hospital, Lu’an, Anhui Province, People’s Republic of China Background and purpose: Lacunar infarct (LI is well known as a heterogeneous primary disorder of cerebral small vessel. Compelling results have demonstrated that age is a risk factor to the prevalence of LI. However, the relationship between age and the prevalence of LI remains obscure. It is essential to note the relationship between age and the prevalence of LI through more clinical data. Methods: A total of 3,500 patients were included in the case-controlled study. All data were collected from the Examination Center of Magnetic Resonance Imaging, Lu’an People’s Hospital from January 2014 to December 2015. A primary discharge diagnosis of LI was done, and all subjects were evaluated as retrospective data. The relationship between the risk factors and the prevalence of diabetes and the relationship between age and the prevalence of diabetes was analyzed. A chi-square test was used to analyze the associations between different variables. A one-way analysis of variance was used to test the equality of three or more means at one time by using variances. Statistical significance was defined as a P-value of <0.05. Results: The one-way analysis of variance demonstrated that the prevalence of LI increased with age before 60 years and decreased with age after 69 years. The same results were found in both the male and the female subjects. These results showed that the age-related risk factors (hypertension, diabetes, cerebral infarct, cardiovascular diseases, smoking, and drinking have no relationship with the prevalence of LI on the basis of age. There is

  19. Aging embrittlement and lattice image analysis in a Fe-Cr-Ni duplex stainless steel aged at 400 C

    International Nuclear Information System (INIS)

    Aging embrittlement, normally observed in ferritic stainless steels, was found in a Fe-Cr-Ni duplex stainless steel thermally aged at 400 C for a long time. The ferrite content and composition of the duplex stainless steel was changed by varying the solution annealing temperature in order to investigate the effect of ferrite phase on the aging embrittlement. The material was aged at 400 C up to 10 000 h. Aging embrittlement was characterized by microhardness and other mechanical tests. The results show that the aging embrittlement of the duplex stainless steel was attributed to the degradation in ferrite phase. Microstructural studies in the ferrite phase indicated that spinodal decomposition and G-phase precipitation led to the degradation. High resolution electron microscopy (HREM) was utilized to analyze the lattice images of G-phase and ferrite matrix. The extent of embrittlement was found to be strongly dependent on the ferrite content and the composition in ferrite. The Ni content in ferrite seems to play an important role in aging embrittlement by promoting G-phase precipitation. As Ni content increased in the ferrite, the degradation of the material aged at 400 C became more severe. ((orig.))

  20. Transcriptome analysis in Ceratitis capitata to unveil genes involved in ageing-maturation process

    Directory of Open Access Journals (Sweden)

    V. San Andrés

    2013-07-01

    Full Text Available The sterile insect technique (SIT is widely used in integrated programmes against the Mediterranean fruit fly, Ceratitis capitata (Wiedemann (Diptera: Tephritidae. Information on the age distribution of insects, and more particularly, the knowledge of wild female reproductive status (mature or not at the time of the sterile male release is one of the key factors for the success of the SIT. In recent years, sequencing analysis has become an important tool in molecular biology. In this work we present a genome-wide expression analysis based on SSH (substractive sequence hybridization and EST (expressed sequence tag sequencing and macroarray expression analysis to identify signature genes related to the ageing-maturing process in C. capitata, leading to the successful identification of new putative candidate genes of reproductive status in medfly that would serve as molecular markers for ageing. We have sorted out 94 unigenes from 873 single-pass ESTs, of which 57% have homology with known genes. Ageing-maturing process in C. capitata presents a marked expression pattern accompanied by the increase of transcription level of genes involved in reproduction (vitellogenins, chorion proteins and male-specific serum proteins. Other identified cDNAs (43% with a differential expression pattern would be also candidates but deserve further studies, as they belong to the unknown function class.

  1. Exergo-Economic Analysis of an Experimental Aircraft Turboprop Engine Under Low Torque Condition

    Science.gov (United States)

    Atilgan, Ramazan; Turan, Onder; Aydin, Hakan

    Exergo-economic analysis is an unique combination of exergy analysis and cost analysis conducted at the component level. In exergo-economic analysis, cost of each exergy stream is determined. Inlet and outlet exergy streams of the each component are associated to a monetary cost. This is essential to detect cost-ineffective processes and identify technical options which could improve the cost effectiveness of the overall energy system. In this study, exergo-economic analysis is applied to an aircraft turboprop engine. Analysis is based on experimental values at low torque condition (240 N m). Main components of investigated turboprop engine are the compressor, the combustor, the gas generator turbine, the free power turbine and the exhaust. Cost balance equations have been formed for all components individually and exergo-economic parameters including cost rates and unit exergy costs have been calculated for each component.

  2. Individual Subject Meta-Analysis of Parameters for Giardia duodenalis Shedding in Animal Experimental Models

    Directory of Open Access Journals (Sweden)

    A. D. Adell

    2014-01-01

    Full Text Available Giardia duodenalis is a zoonotic protozoan parasite with public health importance worldwide. While articles about animal model infectivity have been published for G. duodenalis, the studies have used diverse protocols and parameters to evaluate the infectivity of this protozoan parasite. Hence, the objectives of this study were to (1 conduct a meta-analysis of published literature for cyst shedding and diarrhea outcomes in animal models and (2 develop recommendations to help standardize experimental dose response studies. Results showed that, for the outcome of cyst shedding in faeces, the covariates of infective stage (cyst versus trophozoite, Giardia dose, and the interactions between doses and infective stage, as well as dose and species of experimental host, were all significant (P value ≤ 0.05. This study suggests inoculation of the experimental host with cysts rather than trophozoites and administration of higher doses of Giardia will most likely result in cyst shedding. Based on the results of this meta-analysis, the infective stage (cyst versus trophozoite, parasite dose, and the interactions between dose and infective stage, as well as dose and species of experimental host, should be considered when designing experimental dose response studies that will assist in the study of zoonotic neglected tropical diseases globally.

  3. Conceptualizing age-friendly community characteristics in a sample of urban elders: an exploratory factor analysis.

    Science.gov (United States)

    Smith, Richard J; Lehning, Amanda J; Dunkle, Ruth E

    2013-01-01

    Accurate conceptualization and measurement of age-friendly community characteristics would help to reduce barriers to documenting the effects on elders of interventions to create such communities. This article contributes to the measurement of age-friendly communities through an exploratory factor analysis of items reflecting an existing US Environmental Protection Agency policy framework. From a sample of urban elders (n = 1,376), we identified 6 factors associated with demographic and health characteristics: access to business and leisure, social interaction, access to health care, neighborhood problems, social support, and community engagement. Future research should explore the effects of these factors across contexts and populations.

  4. ANALYSIS OF CORRELATION BETWEENTHE EXPENSES OF SOCIAL PROTECTION AND THE ANTICIPATED OLD AGE PENSION

    OpenAIRE

    Nicolae Daniel Militaru

    2015-01-01

    In this article, I have analysed two components of our social protection system in our country: the expenses of social protection and the anticipated old age pension. The main goal of the study is the analysis of the correlation that exists between the expenses with social protection and the anticipated old age pension, while the secondary goal of the study consists of the identification of the way in which the pension increases to an increase of the expenses with social protection by one uni...

  5. Quantitative analysis of mechanisms that govern red blood cell age structure and dynamics during anaemia.

    Directory of Open Access Journals (Sweden)

    Nicholas J Savill

    2009-06-01

    Full Text Available Mathematical modelling has proven an important tool in elucidating and quantifying mechanisms that govern the age structure and population dynamics of red blood cells (RBCs. Here we synthesise ideas from previous experimental data and the mathematical modelling literature with new data in order to test hypotheses and generate new predictions about these mechanisms. The result is a set of competing hypotheses about three intrinsic mechanisms: the feedback from circulating RBC concentration to production rate of immature RBCs (reticulocytes in bone marrow, the release of reticulocytes from bone marrow into the circulation, and their subsequent ageing and clearance. In addition we examine two mechanisms specific to our experimental system: the effect of phenylhydrazine (PHZ and blood sampling on RBC dynamics. We performed a set of experiments to quantify the dynamics of reticulocyte proportion, RBC concentration, and erythropoietin concentration in PHZ-induced anaemic mice. By quantifying experimental error we are able to fit and assess each hypothesis against our data and recover parameter estimates using Markov chain Monte Carlo based Bayesian inference. We find that, under normal conditions, about 3% of reticulocytes are released early from bone marrow and upon maturation all cells are released immediately. In the circulation, RBCs undergo random clearance but have a maximum lifespan of about 50 days. Under anaemic conditions reticulocyte production rate is linearly correlated with the difference between normal and anaemic RBC concentrations, and their release rate is exponentially correlated with the same. PHZ appears to age rather than kill RBCs, and younger RBCs are affected more than older RBCs. Blood sampling caused short aperiodic spikes in the proportion of reticulocytes which appear to have a different developmental pathway than normal reticulocytes. We also provide evidence of large diurnal oscillations in serum erythropoietin levels

  6. The theoretical analysis and experimental research on the optimal condition of semiconductor refrigeration

    Science.gov (United States)

    Pang, Y. F.

    2016-08-01

    The traditional limiting conditions have the biggest refrigeration quantity condition and the biggest refrigeration coefficient condition, there is a special operating mode during these conditions, enabling to both have the big refrigeration quantity and the small power loss, this operating mode is “Optimum condition”. This article first carried on the theoretical analysis to the semiconductor's optimum condition, inferred optimum electric current's theoretical formula; Carried on the experiment again to a semiconductor refrigeration box by regulating current changing operating mode, which had analyzed performance parameter's change situation under 8 kinds of condition experiments, carried on the regression analysis to the experimental data, obtained the regression equation thus discovered optimum electric current corresponding optimum condition. Carried on working under this condition, and then obtained the big refrigeration quantity and small power, which enhanced the refrigeration performance of semiconductor refrigerator. The experimental result and the theoretical analysis result tallied basically.

  7. An experimental-numerical method for comparative analysis of joint prosthesis

    International Nuclear Information System (INIS)

    The difficulty that exists in the analysis of mechanical stresses in bones is high due to its complex mechanical and morphological characteristics. This complexity makes generalists modelling and conclusions derived from prototype tests very questionable. In this article a relatively simple comparative analysis systematic method that allow us to establish some behaviour differences in different kind of prosthesis is presented. The method, applicable in principle to any joint problem, is based on analysing perturbations produced in natural stress states of a bone after insertion of a joint prosthesis and combines numerical analysis using a 3-D finite element model and experimental studies based on photoelastic coating and electric extensometry. The experimental method is applied to compare two total hip prosthesis cement-free femoral stems of different philosophy. One anatomic of new generation, being of oblique setting over cancellous bone and the other madreporique of trochantero-diaphyseal support over cortical bone. (Author) 4 refs

  8. Experimental investigation and performance analysis of inertia properties measurement for heavy truck cab

    Directory of Open Access Journals (Sweden)

    Tianjun Zhu

    2015-11-01

    Full Text Available An experimental investigation and performance analysis of inertia properties measurement for heavy truck cab is presented. This method is specifically intended for measuring the inertia properties of irregular rigid bodies, and it has the potential to be applied to the measurement of the inertia properties of vehicle bodies, such as the cab, engine, and gearbox. This article, based on CATARC moment of inertia measurement system test rig, develops an accurate measuring method to identify inertia parameters of heavy truck cab. First, corresponding tests are carried out, and the lever principle and moments of inertia parallel theorem are employed to calculate and analyse the test results, which leads to the accurate value of inertia parameters. Second, the performance analysis of the proposed method is verified through the measurement error analysis. As a result, the proposed method shows high accuracy, which provides an experimental basis for accurate inertia parameter measurement of heavy truck cab.

  9. Development of Evaluation Methods for Lower Limb Function between Aged and Young Using Principal Component Analysis

    Science.gov (United States)

    Nomoto, Yohei; Yamashita, Kazuhiko; Ohya, Tetsuya; Koyama, Hironori; Kawasumi, Masashi

    There is the increasing concern of the society to prevent the fall of the aged. The improvement in aged people's the muscular strength of the lower-limb, postural control and walking ability are important for quality of life and fall prevention. The aim of this study was to develop multiple evaluation methods in order to advise for improvement and maintenance of lower limb function between aged and young. The subjects were 16 healthy young volunteers (mean ± S.D: 19.9 ± 0.6 years) and 10 healthy aged volunteers (mean ± S.D: 80.6 ± 6.1 years). Measurement items related to lower limb function were selected from the items which we have ever used. Selected measurement items of function of lower are distance of extroversion of the toe, angle of flexion of the toe, maximum width of step, knee elevation, moving distance of greater trochanter, walking balance, toe-gap force and rotation range of ankle joint. Measurement items summarized by the principal component analysis into lower ability evaluation methods including walking ability and muscle strength of lower limb and flexibility of ankle. The young group demonstrated the factor of 1.6 greater the assessment score of walking ability compared with the aged group. The young group demonstrated the factor of 1.4 greater the assessment score of muscle strength of lower limb compared with the aged group. The young group demonstrated the factor of 1.2 greater the assessment score of flexibility of ankle compared with the aged group. The results suggested that it was possible to assess the lower limb function of aged and young numerically and to advise on their foot function.

  10. A mechanical analysis of metallic tritide aging by helium bubble growth

    Energy Technology Data Exchange (ETDEWEB)

    Montheillet, F. [Ecole Nationale Superieure des Mines (SMS), CNRS UMR 5146 (PECM), 158 cours Fauriel, 42023 Saint-Etienne Cedex 2 (France)], E-mail: montheil@emse.fr; Delaplanche, D.; Fabre, A.; Munier, E.; Thiebaut, S. [Commissariat a l' Energie Atomique de Valduc, 21120 Is-sur-Tille (France)

    2008-10-25

    A simple mechanical model is proposed for the aging of a metallic tritide. The material is assumed to be elastic-power law viscoplastic. Part of the helium atoms generated by tritium decay form spherical bubbles that weaken the elastic moduli of the overall material. By contrast, others can be stored in solid solution in the matrix and are likely to increase the moduli. Two variants of the model are compared, assuming either instantaneous or finite rate diffusion of helium. They predict globally similar evolutions of the gas pressure inside the bubbles, the geometrical parameters (bubble radius, overall swelling), as well as the matrix and overall elastic moduli. The results are in good agreement with atomistic calculations of the pressure evolution. Furthermore, recent experimental measurements of the Young modulus changes during aging are better reproduced when He diffusion rate is finite, thus supporting the second variant of the model.

  11. Fusion of Fingerprint and Age Biometric for Gender Classification Using Frequency and Texture Analysis

    Directory of Open Access Journals (Sweden)

    S. S. Gornale

    2014-12-01

    Full Text Available Classification of gender from fingerprints is one of the important steps in forensic anthropology. This forensic anthropology is used to identify the gender of a criminal in order to minimize the suspects list of search. A very few researcher have worked on gender classification using fingerprints and have gain the competitive results. In this work we are trying to fuse the fingerprint and age biometrics for gender classification. The real fingerprints were collected from different age groups such as 15-20 years and 20- 60 years of the rural and urban people. According to this experimental observation soft biometric information can be used significantly to improve the recognition performance of biometric system. The overall performance of the proposed method is found to be satisfactory and more competitive.

  12. Fetal autonomic brain age scores, segmented heart rate variability analysis, and traditional short term variability

    Directory of Open Access Journals (Sweden)

    Dirk eHoyer

    2014-11-01

    Full Text Available Disturbances of fetal autonomic brain development can be evaluated from fetal heart rate patterns reflecting the activity of the autonomic nervous system. Although heart rate pattern analysis from cardiotocographic (CTG recordings is established for fetal surveillance, temporal resolution is low. Fetal magnetocardiography (MCG, however, provides stable continuous recordings at a higher temporal resolution combined with a more precise heart rate variability (HRV analysis. A direct comparison of CTG and MCG based HRV analysis is pending. The aims of the present study are (i to compare the fetal maturation age predicting value of the MCG based fetal Autonomic Brain Age Score (fABAS approach with that of CTG based Dawes Redman methodology and (ii to elaborate fABAS methodology by segmentation according to fetal behavioral states and heart rate patterns. We investigated MCG recordings from 418 normal fetuses, aged between 21 and 40 weeks of gestation.In linear regression models we obtained an age predicting value of CTG compatible short term variability (STV of R2=0.200 (coefficient of determination in contrast to MCG/fABAS related multivariate models with R2=0.648 in 30 minute recordings, R2=0.610 in active sleep segments of 10 minutes, and R2=0.626 in quiet sleep segments of 10 minutes. Additionally segmented analysis under particular exclusion of accelerations and decelerations in quiet sleep resulted in a novel multivariate model with R2=0.706.According to our results, fMCG based fABAS may provide a promising tool for the estimation of fetal autonomic brain age. Beside other traditional and novel HRV indices as possible indicators of developmental disturbances, the establishment of a fABAS score normogram may represent a specific reference. The present results are intended to contribute to further exploration and validation using independent data sets and multicenter research structures.

  13. Experimental investigation and CFD analysis on cross flow in the core of PMR200

    International Nuclear Information System (INIS)

    Highlights: • An experimental facility for the cross flow in the core of PMR200 was constructed. • The cross flow experimental data were produced with wedge-shaped gap and parallel gap. • The experimental results were compared with CFD results. • The results of the CFD analysis and experimental data are in good agreement. • The pressure loss coefficient for the cross gap of PMR200 was derived. - Abstract: The Prismatic Modular Reactor (PMR) is one of the major Very High Temperature Reactor (VHTR) concepts, which consists of hexagonal prismatic fuel blocks and reflector blocks made of nuclear grade graphite. However, the shape of the graphite blocks could be easily changed by neutron damage during the reactor operation and the shape change can create gaps between the blocks inducing the bypass flow. In the VHTR core, two types of gaps, a vertical gap and a horizontal gap which are called bypass gap and cross gap, respectively, can be formed. The cross gap complicates the flow field in the reactor core by connecting the coolant channel to the bypass gap and it could lead to a loss of effective coolant flow in the fuel blocks. Thus, a cross flow experimental facility was constructed to investigate the cross flow phenomena in the core of the VHTR and a series of experiments were carried out under varying flow rates and gap sizes. The results of the experiments were compared with CFD (Computational Fluid Dynamics) analysis results in order to verify its prediction capability for the cross flow phenomena. Fairly good agreement was seen between experimental results and CFD predictions and the local characteristics of the cross flow was discussed in detail. Based on the calculation results, pressure loss coefficient across the cross gap was evaluated, which is necessary for the thermo-fluid analysis of the VHTR core using a lumped parameter code

  14. Financial analysis of experimental releases conducted at Glen Canyon Dam during water years 2006 through 2010.

    Energy Technology Data Exchange (ETDEWEB)

    Poch, L. A.; Veselka, T. D.; Palmer, C. S.; Loftin, S.; Osiek, B. (Decision and Information Sciences); (Western Area Power Administration, Colorado River Storage Project Management Center)

    2011-08-22

    Because of concerns about the impact that Glen Canyon Dam (GCD) operations were having on downstream ecosystems and endangered species, the Bureau of Reclamation (Reclamation) conducted an Environmental Impact Statement (EIS) on dam operations (DOE 1996). New operating rules and management goals for GCD that had been specified in the Record of Decision (ROD) (Reclamation 1996) were adopted in February 1997. In addition to issuing new operating criteria, the ROD mandated experimental releases for the purpose of conducting scientific studies. A report released in January 2011 examined the financial implications of the experimental flows that were conducted at the GCD from 1997 to 2005. This report continues the analysis and examines the financial implications of the experimental flows conducted at the GCD from 2006 to 2010. An experimental release may have either a positive or negative impact on the financial value of energy production. This study estimates the financial costs of experimental releases, identifies the main factors that contribute to these costs, and compares the interdependencies among these factors. An integrated set of tools was used to compute the financial impacts of the experimental releases by simulating the operation of the GCD under two scenarios, namely, (1) a baseline scenario that assumes both that operations comply with the ROD operating criteria and the experimental releases that actually took place during the study period, and (2) a 'without experiments' scenario that is identical to the baseline scenario of operations that comply with the GCD ROD, except it assumes that experimental releases did not occur. The Generation and Transmission Maximization (GTMax) model was the main simulation tool used to dispatch GCD and other hydropower plants that comprise the Salt Lake City Area Integrated Projects (SLCA/IP). Extensive data sets and historical information on SLCA/IP powerplant characteristics, hydrologic conditions, and Western

  15. Errors associated with metabolic control analysis. Application Of Monte-Carlo simulation of experimental data.

    Science.gov (United States)

    Ainscow, E K; Brand, M D

    1998-09-21

    The errors associated with experimental application of metabolic control analysis are difficult to assess. In this paper, we give examples where Monte-Carlo simulations of published experimental data are used in error analysis. Data was simulated according to the mean and error obtained from experimental measurements and the simulated data was used to calculate control coefficients. Repeating the simulation 500 times allowed an estimate to be made of the error implicit in the calculated control coefficients. In the first example, state 4 respiration of isolated mitochondria, Monte-Carlo simulations based on the system elasticities were performed. The simulations gave error estimates similar to the values reported within the original paper and those derived from a sensitivity analysis of the elasticities. This demonstrated the validity of the method. In the second example, state 3 respiration of isolated mitochondria, Monte-Carlo simulations were based on measurements of intermediates and fluxes. A key feature of this simulation was that the distribution of the simulated control coefficients did not follow a normal distribution, despite simulation of the original data being based on normal distributions. Consequently, the error calculated using simulation was greater and more realistic than the error calculated directly by averaging the original results. The Monte-Carlo simulations are also demonstrated to be useful in experimental design. The individual data points that should be repeated in order to reduce the error in the control coefficients can be highlighted.

  16. Experimental and theoretical analysis of fiber Bragg gratings under Transverse Force to a Small Grating Section

    Institute of Scientific and Technical Information of China (English)

    WU Fei; LI Li-xin; LI Ya-pin; LI Zhi-quan

    2005-01-01

    Fiber Bragg grating under transverse force on a small grating section is studied by numerical simulation and experimentation. A numerical simulation based on the transfer matrix method is used to calculate the consequent changes in reflected spectrum. The reflected spectra of the FBG subjected to the transverse force split into two main peaks, and the split point shifted linearly and periodically versus the applied force. The split point is shifted in the bandwidth with the period of 11N, and the sensitivity of the split point wavelength shift versus the applied force is 0.05 nm/N in one period. The experimental results show good agreement with the simulation analysis.

  17. 1988 Progress report of the EDF department for the analysis of experimental data and measurements

    International Nuclear Information System (INIS)

    The 1988 activity report of the department for the analysis of experimental data and measurements (Department of Retour d'Experience Mesures-Essais, of EDF, France), is presented. The mission of the department is to collect and investigate data from the nuclear power plant operations. The investigations started before 1988, were carried on in 1988. The department main activities are: technology and information transfer from experimental activities, the construction of a standard data acquisition and processing system, the actions involving the N4 turbine, and the modelling and construction of new non-destructive methods of control. The most important facts and activities carried out in 1988 are presented

  18. Experimental Demonstration and Theoretical Analysis of Slow Light in a Semiconductor Waveguide at GHz Frequencies

    DEFF Research Database (Denmark)

    Mørk, Jesper; Kjær, Rasmus; Poel, Mike van der;

    2005-01-01

    Experimental demonstration and theoretical analysis of slow light in a semiconductor waveguide at GHz frequencies slow-down of light by a factor of two in a semiconductor waveguide at room temperature with a bandwidth of 16.7 GHz using the effect of coherent pulsations of the carrier density....... The achievable delay is shown to be limited by the short lifetime. The maximum time delay observed reflects an approximately two-fold increase of the group refractive index, corresponding to a time delay of approximately 20 % of the carrier (population) lifetime. The experimental observations are well...

  19. Experimental and FE Analysis of Exterior Plastic Components of Cars under Static and Dynamic Loading Conditions

    OpenAIRE

    Faghihi, Hassan

    2011-01-01

    This thesis is composed by an experimental part and numerical part, aimed at contributing to a better knowledge of the behavior of plastic parts under different loading conditions. The study is intended to validate a FE model for simulating exterior plastic components of car especially the A-decor and plastic clips in the context of thermal and static load analysis. From the comparison of numerical and experimental results in the terms of thermal and static deformation of the A-decor, it is c...

  20. Efficient experimental design and analysis strategies for the detection of differential expression using RNA-Sequencing

    Directory of Open Access Journals (Sweden)

    Robles José A

    2012-09-01

    Full Text Available Abstract Background RNA sequencing (RNA-Seq has emerged as a powerful approach for the detection of differential gene expression with both high-throughput and high resolution capabilities possible depending upon the experimental design chosen. Multiplex experimental designs are now readily available, these can be utilised to increase the numbers of samples or replicates profiled at the cost of decreased sequencing depth generated per sample. These strategies impact on the power of the approach to accurately identify differential expression. This study presents a detailed analysis of the power to detect differential expression in a range of scenarios including simulated null and differential expression distributions with varying numbers of biological or technical replicates, sequencing depths and analysis methods. Results Differential and non-differential expression datasets were simulated using a combination of negative binomial and exponential distributions derived from real RNA-Seq data. These datasets were used to evaluate the performance of three commonly used differential expression analysis algorithms and to quantify the changes in power with respect to true and false positive rates when simulating variations in sequencing depth, biological replication and multiplex experimental design choices. Conclusions This work quantitatively explores comparisons between contemporary analysis tools and experimental design choices for the detection of differential expression using RNA-Seq. We found that the DESeq algorithm performs more conservatively than edgeR and NBPSeq. With regard to testing of various experimental designs, this work strongly suggests that greater power is gained through the use of biological replicates relative to library (technical replicates and sequencing depth. Strikingly, sequencing depth could be reduced as low as 15% without substantial impacts on false positive or true positive rates.

  1. Long-term aging and degradation of microplastic particles: Comparing in situ oceanic and experimental weathering patterns.

    Science.gov (United States)

    Brandon, Jennifer; Goldstein, Miriam; Ohman, Mark D

    2016-09-15

    Polypropylene, low-density polyethylene, and high-density polyethylene pre-production plastic pellets were weathered for three years in three experimental treatments: dry/sunlight, seawater/sunlight, and seawater/darkness. Changes in chemical bond structures (hydroxyl, carbonyl groups and carbon-oxygen) with weathering were measured via Fourier Transform Infrared (FTIR) spectroscopy. These indices from experimentally weathered particles were compared to microplastic particles collected from oceanic surface waters in the California Current, the North Pacific Subtropical Gyre, and the transition region between the two, in order to estimate the exposure time of the oceanic plastics. Although chemical bonds exhibited some nonlinear changes with environmental exposure, they can potentially approximate the weathering time of some plastics, especially high-density polyethylene. The majority of the North Pacific Subtropical Gyre polyethylene particles we measured have inferred exposure times>18months, with some >30months. Inferred particle weathering times are consistent with ocean circulation models suggesting a long residence time in the open ocean.

  2. Long-term aging and degradation of microplastic particles: Comparing in situ oceanic and experimental weathering patterns.

    Science.gov (United States)

    Brandon, Jennifer; Goldstein, Miriam; Ohman, Mark D

    2016-09-15

    Polypropylene, low-density polyethylene, and high-density polyethylene pre-production plastic pellets were weathered for three years in three experimental treatments: dry/sunlight, seawater/sunlight, and seawater/darkness. Changes in chemical bond structures (hydroxyl, carbonyl groups and carbon-oxygen) with weathering were measured via Fourier Transform Infrared (FTIR) spectroscopy. These indices from experimentally weathered particles were compared to microplastic particles collected from oceanic surface waters in the California Current, the North Pacific Subtropical Gyre, and the transition region between the two, in order to estimate the exposure time of the oceanic plastics. Although chemical bonds exhibited some nonlinear changes with environmental exposure, they can potentially approximate the weathering time of some plastics, especially high-density polyethylene. The majority of the North Pacific Subtropical Gyre polyethylene particles we measured have inferred exposure times>18months, with some >30months. Inferred particle weathering times are consistent with ocean circulation models suggesting a long residence time in the open ocean. PMID:27344287

  3. Age and Anomia in Middle and Later Life: A Multivariate Analysis of a National Sample of White Men.

    Science.gov (United States)

    Pope, Hallowell; Ferguson, Miller Dwayne

    1982-01-01

    Tested whether the aged status in America results in distrust and despair with the social order (anomia). A multivariate regression analysis utilizing data on 354 men aged 40 and older showed no relationship between age or other indicators of life chances or anomia, net of education and/or verbal intelligence. (Author/RC)

  4. Correlation analysis of indicators of physical and technical preparedness karate school age

    Directory of Open Access Journals (Sweden)

    Sklyar M. S.

    2014-03-01

    Full Text Available Purpose: identification of basic indicators of physical qualities at karate school age. Material : in the experiment involved 30 students, ages 16-18 years, with experience training Shotokan Karate 10 years. Results : the density of the relationship of indicators of physical and technical preparedness of the students of the senior classes of secondary school, with long experience of employment Shotokan Karate. Results identified training standards regulated program of physical culture for secondary schools (grades 10-11 and technical characteristics often performed percussion techniques in competitive fights in Shotokan Karate using techniques and specialized shock chronodynamometry ergometer. Correlation analysis revealed that the greatest influence on the formation of shock art of karate techniques at this age is the level of development of high-speed capacity, endurance, strength, complex muscle groups and mobility in the hip joint. Conclusions : the landmark data indicators positively affects the formation of karate techniques.

  5. A Randomised Controlled Experimental Study on the Influence of Patient Age on Medical Decisions in Respect to the Diagnosis and Treatment of Depression in the Elderly

    Directory of Open Access Journals (Sweden)

    Michael Linden

    2009-01-01

    Full Text Available Background. Elderly patients are often treated differently than younger patients, even when suffering from the same disorder. Objective. The study examines the influence of “patient age” on the perception of symptoms and conclusions of physicians in respect to diagnosis and treatment. Methods. In a randomised controlled experimental study on medical decision-making, 121 general practitioners were given two case vignettes which contained all the criteria for major depression according to ICD-10, but differed in respect to the age of the patient (39 or 81. Reaction time, diagnostic conclusions and therapeutic recommendations were assessed by computer. Results. Depression and anxiety were significantly seen as more probable in the young cases and dementia and physical illness in the old. In young age, psychotherapy, pharmacotherapy and referral to a specialist or inpatient treatment were significantly more recommended than in old age, for whom supportive counselling was significantly more recommended. The time needed for a decision was significantly longer in the older patients. Conclusion. Ageing stereotypes can also form medical illness concepts and have a significant influence on diagnostic and therapeutic decisions.

  6. Brain SPECT of chronic fatigue syndrome (CFS): SPM analysis of two age groups

    International Nuclear Information System (INIS)

    Full text: Chronic fatigue syndrome (CFS) is a complex disorder characterised by profound fatigue and neuropsychiatric dysfunction. Previous studies with cerebral perfusion SPECT (rCBF) scans were performed with inhomogeneous patient populations and were not analysed with Statistical Parametric Mapping (SPM). We have used SPM to study subjects with moderate CFS based on the Fukuda criteria, who were not on medication and not depressed, compared to age matched control subjects. An apparent bimodal age distribution has been observed in CFS. Subjects were therefore divided into two age groups: 16-35 or under 35 (17 CFS, 11 control) and 36-61 or over 35 (15 CFS, 15 control). HMPAO brain SPECT was acquired on a 3-head camera. After lower window scatter subtraction, reconstruction with attenuation correction (mu=0.15/cm) and editing of facial activity, scans were spatially normalised (affine + 2x3x2 nonlinear) to SPM's anatomical space. SPM statistical analysis yielded the location, amplitude and corrected p-value of significant focal rCBF deficits. They were: for under 35, left lateral temporal lobe (13%, 0.004), the left insular region (15%, 0.006) and the right lentiform nucleus (15%, 0.01); and for over 35 the left lentiform nucleus (18%, 0.01). Counts at the most significant voxel in the under 35 age group permitted separation of the CFS and control groups with sensitivity 94% and specificity 100%. We are acquiring more controls to better define the age and sex dependence of rCBF in CFS. Analysis of associated clinical variables will be used to investigate the observed differences between the two age groups. Copyright (2002) The Australian and New Zealand Society of Nuclear Medicine Inc

  7. Analysis, prediction, and case studies of early-age cracking in bridge decks

    Science.gov (United States)

    ElSafty, Adel; Graeff, Matthew K.; El-Gharib, Georges; Abdel-Mohti, Ahmed; Mike Jackson, N.

    2016-06-01

    Early-age cracking can adversely affect strength, serviceability, and durability of concrete bridge decks. Early age is defined as the period after final setting, during which concrete properties change rapidly. Many factors can cause early-age bridge deck cracking including temperature change, hydration, plastic shrinkage, autogenous shrinkage, and drying shrinkage. The cracking may also increase the effect of freeze and thaw cycles and may lead to corrosion of reinforcement. This research paper presents an analysis of causes and factors affecting early-age cracking. It also provides a tool developed to predict the likelihood and initiation of early-age cracking of concrete bridge decks. Understanding the concrete properties is essential so that the developed tool can accurately model the mechanisms contributing to the cracking of concrete bridge decks. The user interface of the implemented computer Excel program enables the user to input the properties of the concrete being monitored. The research study and the developed spreadsheet were used to comprehensively investigate the issue of concrete deck cracking. The spreadsheet is designed to be a user-friendly calculation tool for concrete mixture proportioning, temperature prediction, thermal analysis, and tensile cracking prediction. The study also provides review and makes recommendations on the deck cracking based mainly on the Florida Department of Transportation specifications and Structures Design Guidelines, and Bridge Design Manuals of other states. The results were also compared with that of other commercially available software programs that predict early-age cracking in concrete slabs, concrete pavement, and reinforced concrete bridge decks. The outcome of this study can identify a set of recommendations to limit the deck cracking problem and maintain a longer service life of bridges.

  8. [Aging Process of Puer Black Tea Studied by FTIR Spectroscopy Combined with Curve-Fitting Analysis].

    Science.gov (United States)

    Li, Dong-yu; Shi, You-ming; Yi, Shi Lai

    2015-07-01

    For better determination of the chemical components in the Puer black tea, Fourier transform infrared spectroscopy was used for obtaining vibrational spectra of Puer black tea at different aging time. Fourier transform infrared (FTIR) spectra indicated that the chemical components had change in Puer black tea at different aging time. The leaf of Puer black tea was a complex system, its Fourier transform infrared spectrum showed a total overlap of each absorption spectrum of various components. Each band represented an overall overlap of some characteristic absorption peaks of functional groups in the Puer black tea. In order to explore the change of characteristic absorption peaks of functional groups with aging time, the prediction positions and the number of second peaks in the range of 1900-900 cm(-1) were determined by Fourier self-deconvolution at first, and later the curve fitting analysis was performed in this overlap band. At different aging time of Puer black tea, the wave number of second peaks of amide II, tea polyphenol, pectin and polysaccharides at overlap band were assigned by curve fitting analysis. The second peak at 1520 cm(-1) was characteristic absorption band of amide II, the second peaks of tea polyphenol and pectin appeared at 1278 and 1103 cm(-1) respectively. Two second peaks at 1063 and 1037 cm(-1), corresponds mainly to glucomannan and arabinan. The relative area of these second peaks could be indicated the content of protein, tea polyphenol, pectin and polysaccharides in the Puer black tea. The results of curve fitting analysis showed that the relative area of amide II was increasing first and then decreasing, it indicated the change of protein in Puer black tea. At the same time, the content of tea polyphenol and pectin were decreased with the increase of aging time, but the glucomannan and arabinan were increased in reverse. It explained that the bitter taste was become weak and a sweet taste appeared in the tea with the increase of

  9. Quantitative analysis of cone photoreceptor distribution and its relationship with axial length, age, and early age-related macular degeneration.

    Directory of Open Access Journals (Sweden)

    Ryo Obata

    Full Text Available PURPOSE: It has not been clarified whether early age-related macular degeneration (AMD is associated with cone photoreceptor distribution. We used adaptive optics fundus camera to examine cone photoreceptors in the macular area of aged patients and quantitatively analyzed its relationship between the presence of early AMD and cone distribution. METHODS: Sixty cases aged 50 or older were studied. The eyes were examined with funduscopy and spectral-domain optical coherence tomography to exclude the eyes with any abnormalities at two sites of measurement, 2° superior and 5° temporal to the fovea. High-resolution retinal images with cone photoreceptor mosaic were obtained with adaptive optics fundus camera (rtx1, Imagine Eyes, France. After adjusting for axial length, cone packing density was calculated and the relationship with age, axial length, or severity of early AMD based on the age-related eye disease study (AREDS classification was analyzed. RESULTS: Patient's age ranged from 50 to 77, and axial length from 21.7 to 27.5 mm. Mean density in metric units and that in angular units were 24,900 cells/mm2, 2,170 cells/deg2 at 2° superior, and 18,500 cells/mm2, 1,570 cels/deg2 at 5° temporal, respectively. Axial length was significantly correlated with the density calculated in metric units, but not with that in angular units. Age was significantly correlated with the density both in metric and angular units at 2° superior. There was no significant difference in the density in metric and angular units between the eyes with AREDS category one and those with categories two or three. CONCLUSION: Axial length and age were significantly correlated with parafoveal cone photoreceptor distribution. The results do not support that early AMD might influence cone photoreceptor density in the area without drusen or pigment abnormalities.

  10. Experimental and theoretical analysis of vortex breakdown in the wake of the 25∘ Ahmed body

    Science.gov (United States)

    Jermann, Cyril; Meliga, Philippe; Pujals, Gregory; Gallaire, Francois; Serre, Eric

    2014-11-01

    We study experimentally and theoretically the wake of the 25circ; Ahmed body, considered a suitable test-case to reproduce the two counter-rotating longitudinal vortices widely encountered in automotive aerodynamics. The three-dimensional experimental mean flow is reconstructed at high Reynolds number (Re = 2 . 8 ×106) from a series of cross-flow time-averaged planes acquired with a moving automated Stereo-PIV system. We observe a sharp decay of the axial velocity and vorticity in the near-wake, 0 . 5 times the projected length of the slanted surface downstream the square back, where the streamwise vortices is subjected to a strong adverse pressure gradient and the turbulent kinetic energy exhibits a peak in the vortex core. A stability analysis of the experimental velocity shows that the flow undergoes vortex breakdown roughly at the same position, through a transition from supercritical (x 0 . 5) conditions and the accumulation of upstream propagating axisymmetric waves.

  11. Experimental and theoretical analysis of the laser shock cleaning process for nanoscale particle removal

    Science.gov (United States)

    Kim, Dongsik; Oh, Bukuk; Jang, Deoksuk; Lee, Jeong-Wook; Lee, Jong-Myoung

    2007-07-01

    The laser shock cleaning (LSC) process has been shown to be effective for removing submicron-sized contaminant particles from solid surfaces and thus bears strong potential in various applications. In this work, experimental and theoretical analysis are conducted to reveal the underlying physical mechanisms of the LSC process, with emphasis on the laser-induced hydrodynamics and the effect of external gas-jet injection through a nozzle. A two-dimensional theoretical model is proposed for rigorous simulation of the hydrodynamic phenomena occurring in the LSC process. The hydrodynamics computed by the model is in qualitative agreement with experimental observations and reveal the details of the physics involved in the cleaning process. The effect of gas blowing on the cleaning performance is analyzed both experimentally and theoretically. The results indicate that the gas flow can significantly change the hydrodynamics and increase the cleaning efficiency by reducing the chance of particle redeposition.

  12. Updating Finite Element Model of a Wind Turbine Blade Section Using Experimental Modal Analysis Results

    DEFF Research Database (Denmark)

    Luczak, Marcin; Manzato, Simone; Peeters, Bart;

    2014-01-01

    This paper presents selected results and aspects of the multidisciplinary and interdisciplinary research oriented for the experimental and numerical study of the structural dynamics of a bend-twist coupled full scale section of a wind turbine blade structure. The main goal of the conducted research...... is to validate finite element model of the modified wind turbine blade section mounted in the flexible support structure accordingly to the experimental results. Bend-twist coupling was implemented by adding angled unidirectional layers on the suction and pressure side of the blade. Dynamic test and simulations...... were performed on a section of a full scale wind turbine blade provided by Vestas Wind Systems A/S. The numerical results are compared to the experimental measurements and the discrepancies are assessed by natural frequency difference and modal assurance criterion. Based on sensitivity analysis, set...

  13. Experimental study and analysis on fatigue stiffness of RC beams strengthened with CFRP and steel plate

    Institute of Scientific and Technical Information of China (English)

    LU Yi-yan; HU Ling; LI Shan; WANG Kang-hao

    2016-01-01

    The objective of this work is to investigate the fatigue behavior of reinforced concrete (RC) beams strengthened with externally bonded carbon fiber reinforced polymer (CFRP) and steel plate. An experimental investigation and theoretical analysis were made on the law of deflection development and stiffness degradation, as well as the influence of fatigue load ranges. Test results indicate that the law of three-stage change under fatigue loading is followed by both midspan deflection and permanent deflection, which also have positive correlation with fatigue load amplitude. Fatigue stiffness of composite strengthened beams degrades gradually with the increasing of number of cycles. Based on the experimental results, a theoretical model by effective moment of inertia method is developed for calculating the sectional stiffness of such composite strengthened beams under fatigue loading, and the calculated results are in good agreement with the experimental results.

  14. Sexual Dimorphism and Aging in the Human Hyppocampus: Identification, Validation, and Impact of Differentially Expressed Genes by Factorial Microarray and Network Analysis

    Science.gov (United States)

    Guebel, Daniel V.; Torres, Néstor V.

    2016-01-01

    Motivation: In the brain of elderly-healthy individuals, the effects of sexual dimorphism and those due to normal aging appear overlapped. Discrimination of these two dimensions would powerfully contribute to a better understanding of the etiology of some neurodegenerative diseases, such as “sporadic” Alzheimer. Methods: Following a system biology approach, top-down and bottom-up strategies were combined. First, public transcriptome data corresponding to the transition from adulthood to the aging stage in normal, human hippocampus were analyzed through an optimized microarray post-processing (Q-GDEMAR method) together with a proper experimental design (full factorial analysis). Second, the identified genes were placed in context by building compatible networks. The subsequent ontology analyses carried out on these networks clarify the main functionalities involved. Results: Noticeably we could identify large sets of genes according to three groups: those that exclusively depend on the sex, those that exclusively depend on the age, and those that depend on the particular combinations of sex and age (interaction). The genes identified were validated against three independent sources (a proteomic study of aging, a senescence database, and a mitochondrial genetic database). We arrived to several new inferences about the biological functions compromised during aging in two ways: by taking into account the sex-independent effects of aging, and considering the interaction between age and sex where pertinent. In particular, we discuss the impact of our findings on the functions of mitochondria, autophagy, mitophagia, and microRNAs. Conclusions: The evidence obtained herein supports the occurrence of significant neurobiological differences in the hippocampus, not only between adult and elderly individuals, but between old-healthy women and old-healthy men. Hence, to obtain realistic results in further analysis of the transition from the normal aging to incipient

  15. Experimental Methods in Neuroscience: An Undergraduate Neuroscience Laboratory Course for Teaching Ethical Issues, Laboratory Techniques, Experimental Design, and Analysis

    OpenAIRE

    Hall, Adam C.; Harrington, Mary E.

    2003-01-01

    We have developed and recently taught a 200 level undergraduate course entitled, ‘Experimental Methods in Neuroscience’. This is a required course in an increasingly popular Neuroscience major at Smith College. Students are introduced initially to issues of animal ethics and experimentation, and are familiarized with our Animal Care Facility. Using an open field and rotarod apparatus, and the elevated plus and Barnes mazes, they conduct behavioral testing of two strains of mice, C57/BL/6J and...

  16. Isotopic composition analysis and age dating of uranium samples by high resolution gamma ray spectrometry

    Science.gov (United States)

    Apostol, A. I.; Pantelica, A.; Sima, O.; Fugaru, V.

    2016-09-01

    Non-destructive methods were applied to determine the isotopic composition and the time elapsed since last chemical purification of nine uranium samples. The applied methods are based on measuring gamma and X radiations of uranium samples by high resolution low energy gamma spectrometric system with planar high purity germanium detector and low background gamma spectrometric system with coaxial high purity germanium detector. The "Multigroup γ-ray Analysis Method for Uranium" (MGAU) code was used for the precise determination of samples' isotopic composition. The age of the samples was determined from the isotopic ratio 214Bi/234U. This ratio was calculated from the analyzed spectra of each uranium sample, using relative detection efficiency. Special attention is paid to the coincidence summing corrections that have to be taken into account when performing this type of analysis. In addition, an alternative approach for the age determination using full energy peak efficiencies obtained by Monte Carlo simulations with the GESPECOR code is described.

  17. The emergence of modern statistics in agricultural science: analysis of variance, experimental design and the reshaping of research at Rothamsted Experimental Station, 1919-1933.

    Science.gov (United States)

    Parolini, Giuditta

    2015-01-01

    During the twentieth century statistical methods have transformed research in the experimental and social sciences. Qualitative evidence has largely been replaced by quantitative results and the tools of statistical inference have helped foster a new ideal of objectivity in scientific knowledge. The paper will investigate this transformation by considering the genesis of analysis of variance and experimental design, statistical methods nowadays taught in every elementary course of statistics for the experimental and social sciences. These methods were developed by the mathematician and geneticist R. A. Fisher during the 1920s, while he was working at Rothamsted Experimental Station, where agricultural research was in turn reshaped by Fisher's methods. Analysis of variance and experimental design required new practices and instruments in field and laboratory research, and imposed a redistribution of expertise among statisticians, experimental scientists and the farm staff. On the other hand the use of statistical methods in agricultural science called for a systematization of information management and made computing an activity integral to the experimental research done at Rothamsted, permanently integrating the statisticians' tools and expertise into the station research programme. Fisher's statistical methods did not remain confined within agricultural research and by the end of the 1950s they had come to stay in psychology, sociology, education, chemistry, medicine, engineering, economics, quality control, just to mention a few of the disciplines which adopted them.

  18. The emergence of modern statistics in agricultural science: analysis of variance, experimental design and the reshaping of research at Rothamsted Experimental Station, 1919-1933.

    Science.gov (United States)

    Parolini, Giuditta

    2015-01-01

    During the twentieth century statistical methods have transformed research in the experimental and social sciences. Qualitative evidence has largely been replaced by quantitative results and the tools of statistical inference have helped foster a new ideal of objectivity in scientific knowledge. The paper will investigate this transformation by considering the genesis of analysis of variance and experimental design, statistical methods nowadays taught in every elementary course of statistics for the experimental and social sciences. These methods were developed by the mathematician and geneticist R. A. Fisher during the 1920s, while he was working at Rothamsted Experimental Station, where agricultural research was in turn reshaped by Fisher's methods. Analysis of variance and experimental design required new practices and instruments in field and laboratory research, and imposed a redistribution of expertise among statisticians, experimental scientists and the farm staff. On the other hand the use of statistical methods in agricultural science called for a systematization of information management and made computing an activity integral to the experimental research done at Rothamsted, permanently integrating the statisticians' tools and expertise into the station research programme. Fisher's statistical methods did not remain confined within agricultural research and by the end of the 1950s they had come to stay in psychology, sociology, education, chemistry, medicine, engineering, economics, quality control, just to mention a few of the disciplines which adopted them. PMID:25311906

  19. Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders

    OpenAIRE

    Choi, Siwon; Wang, Wei; Ribeiro, Alexandrew J.S.; Kalinowski, Agnieszka; Gregg, Siobhan Q.; Opresko, Patricia L.; Laura J. Niedernhofer; Rohde, Gustavo K.; Dahl, Kris Noel

    2011-01-01

    Computational image analysis is used in many areas of biological and medical research, but advanced techniques including machine learning remain underutilized. Here, we used automated segmentation and shape analyses, with pre-defined features and with computer generated components, to compare nuclei from various premature aging disorders caused by alterations in nuclear proteins. We considered cells from patients with Hutchinson-Gilford progeria syndrome (HGPS) with an altered nucleoskeletal ...

  20. Transcriptome Analysis on Monocytes from Patients with Neovascular Age-Related Macular Degeneration

    OpenAIRE

    Michelle Grunin; Shira- Hagbi-Levi; Batya Rinsky; Yoav Smith; Itay Chowers

    2016-01-01

    Mononuclear phagocytes (MPs), including monocytes/macrophages, play complex roles in age-related macular degeneration (AMD) pathogenesis. We reported altered gene-expression signature in peripheral blood mononuclear cells from AMD patients, and a chemokine receptor signature on AMD monocytes. To obtain comprehensive understanding of MP involvement, particularly in peripheral circulation in AMD, we performed global gene expression analysis in monocytes. We separated monocytes from treatment-na...

  1. A secondary analysis to determine variations of dental arch measurements with age and gender among Ugandans

    OpenAIRE

    Okori, Hilda; Apolot, Pricilla S.; Mwaka, Erisa; Tumusiime, Gerald; Buwembo, William; Munabi, Ian G.

    2015-01-01

    Background Dental arch dimensions are useful in dental practice and in forensic odontology. Local data is essential because ethnic differences exist in dental arch dimensions. In the Ugandan population no studies had been done on dental arch dimensions. The objective of the current study was to determine the variations in dental arch dimensions with age and gender in a sample of dental casts from the Ugandan population. Method This was a secondary analysis of dental casts previously prepared ...

  2. Experimental saltwater intrusion in coastal aquifers using automated image analysis: Applications to homogeneous aquifers

    Science.gov (United States)

    Robinson, G.; Ahmed, Ashraf A.; Hamill, G. A.

    2016-07-01

    This paper presents the applications of a novel methodology to quantify saltwater intrusion parameters in laboratory-scale experiments. The methodology uses an automated image analysis procedure, minimising manual inputs and the subsequent systematic errors that can be introduced. This allowed the quantification of the width of the mixing zone which is difficult to measure in experimental methods that are based on visual observations. Glass beads of different grain sizes were tested for both steady-state and transient conditions. The transient results showed good correlation between experimental and numerical intrusion rates. The experimental intrusion rates revealed that the saltwater wedge reached a steady state condition sooner while receding than advancing. The hydrodynamics of the experimental mixing zone exhibited similar traits; a greater increase in the width of the mixing zone was observed in the receding saltwater wedge, which indicates faster fluid velocities and higher dispersion. The angle of intrusion analysis revealed the formation of a volume of diluted saltwater at the toe position when the saltwater wedge is prompted to recede. In addition, results of different physical repeats of the experiment produced an average coefficient of variation less than 0.18 of the measured toe length and width of the mixing zone.

  3. Analytical and experimental analysis of solute transport in heterogeneous porous media.

    Science.gov (United States)

    Wu, Lei; Gao, Bin; Tian, Yuan; Muñoz-Carpena, Rafael

    2014-01-01

    Knowledge of solute transport in heterogeneous porous media is crucial to monitor contaminant fate and transport in soil and groundwater systems. In this study, we present new findings from experimental and mathematical analysis to improve current understanding of solute transport in structured heterogeneous porous media. Three saturated columns packed with different sand combinations were used to examine the breakthrough behavior of bromide, a conservative tracer. Experimental results showed that bromide had different breakthrough responses in the three types of sand combinations, indicating that heterogeneity in hydraulic conductivity has a significant effect on the solute transport in structured heterogeneous porous media. Simulations from analytical solutions of a two-domain solute transport model matched experimental breakthrough data well for all the experimental conditions tested. Experimental and model results show that under saturated flow conditions, advection dominates solute transport in both fast-flow and slow-flow domains. The sand with larger hydraulic conductivity provided a preferential flow path for solute transport (fast-flow domain) that dominates the mass transfer in the heterogeneous porous media. Importantly, the transport in the slow-flow domain and mass exchange between the domains also contribute to the flow and solute transport processes and thus must be considered when investigating contaminant transport in heterogeneous porous media. PMID:24279625

  4. Assessment of gait symmetry for Talus Valgus children based on experimental kinematic analysis

    Science.gov (United States)

    Toth-Tascau, Mirela; Pasca, Oana; Vigaru, Cosmina; Rusu, Lucian

    2013-10-01

    The general purpose of this study was to assess the gait symmetry for Talus Valgus deformity based on experimental kinematic analysis. As this foot condition generally occurs in children, the study is focused on two children having five years old, one being healthy, as control subject, and the second one having bilateral Talus Valgus deformity. Kinematic experimental analysis was conducted using Zebris CMS-HS Measuring System. The bilateral symmetry was analyzed using two methods: index of symmetry (SI) calculated for spatio-temporal parameters (stance phase, swing phase, and step length) and kinematic parameter (maximum value of dorsiflexion - plantar flexion angle in the ankle joint), and an unpaired t-test to compare the variation of means values of dorsiflexion - plantar flexion angle in ankle joint for both left and right side. The study evidenced a good bilateral symmetry in case of the control subject and quantified the asymmetry in case of subject with Talus Valgus deformity.

  5. Numerical analysis and experimental research of the rubber boot of the joint drive vehicle

    Science.gov (United States)

    Ziobro, Jan

    2016-04-01

    The article presents many numerical studies and experimental research of the drive rubber boot of the joint drive vehicle. Performance requirements have been discussed and the required coefficients of the mathematical model for numerical simulation have been determined. The behavior of living in MSC.MARC environment was examined. In the analysis the following have been used: hyperplastic two-parameter model of the Mooney-Rivlin material, large displacements procedure, safe contact condition, friction on the sides of the boots. 3D numerical model of the joint bootwas analyzed under influence of the forces: tensile, compressive, centrifugal and angular. Numerous results of studies have been presented. An appropriate test stand was built and comparison of the results of the numerical analysis and the results of experimental studies was made. Numerous requests and recommendations for utilitarian character have been presented.

  6. Cooperative Experimental System Development - cooperative techniques beyound initial design and analysis

    DEFF Research Database (Denmark)

    Grønbæk, Kaj; Kyng, Morten; Mogensen, Preben Holst

    1995-01-01

    , however, not limited to this development context, it may be applied for in-house or contract development as well. In system development, particularly in cooperative and experimental system development, we argue that it is necessary to analytically separate the abstract concerns, e.g. analysis, design......This chapter represents a step towards the establishment of a new system development approach, called Cooperative Experimental System Development (CESD). CESD seeks to overcome a number of limitations in existing approaches: specification oriented methods usually assume that system design can...... be based solely on observation and detached reflection; prototyping methods often have a narrow focus on the technical construction of various kinds of prototypes; Participatory Design techniques—including the Scandinavian Cooperative Design (CD) approaches—seldom go beyond the early analysis...

  7. 2000 CKM-triangle analysis a critical review with updated experimental inputs and theoretical parameters

    Energy Technology Data Exchange (ETDEWEB)

    Roudeau, P.; Stocchi, A. [Laboratoire de l' Accelerateur Lineaire, 91 - Orsay (France); Ciuchini, M.; Lubicz, V. [Rome Univ., INFN (Italy); D' Agostini, G.; Franco, E.; Martinelli, G. [Rome Univ. La Sapienza and Sezione INFN, (Italy); Parodi, F. [Universita di Genova and INFN, Dipt. di Fisica (Italy)

    2000-12-01

    Within the Standard Model, a review of the current determination of the sides and angles of the CKM unitarity triangle is presented, using experimental constraints from the measurements of |{epsilon}{sub K}|, |V{sub ub}/V{sub cb}|, {delta}m{sub d} and from the limit on {delta}m{sub s}, available in September 2000. Results from the experimental search for B{sup 0}{sub s}-B-bar{sup 0}{sub s} oscillations are introduced in the present analysis using the likelihood. Special attention is devoted to the determination of the theoretical uncertainties. The purpose of the analysis is to infer regions where the parameters of interest lie with given probabilities. The BaBar '95% C.L. scanning' method is also commented. (authors)

  8. Docosahexaenoic acid signaling modulates cell survival in experimental ischemic stroke penumbra and initiates long-term repair in young and aged rats.

    Directory of Open Access Journals (Sweden)

    Tiffany N Eady

    Full Text Available BACKGROUND: Docosahexaenoic acid, a major omega-3 essential fatty acid family member, improves behavioral deficit and reduces infarct volume and edema after experimental focal cerebral ischemia. We hypothesize that DHA elicits neuroprotection by inducing AKT/p70S6K phosphorylation, which in turn leads to cell survival and protects against ischemic stroke in young and aged rats. METHODS AND RESULTS: Rats underwent 2 h of middle cerebral artery occlusion (MCAo. DHA, neuroprotectin D1 (NPD1 or vehicle (saline was administered 3 h after onset of stroke. Neurological function was evaluated on days 1, 2, 3, and 7. DHA treatment improved functional recovery and reduced cortical, subcortical and total infarct volumes 7 days after stroke. DHA also reduced microglia infiltration and increased the number of astrocytes and neurons when compared to vehicle on days 1 and 7. Increases in p473 AKT and p308 AKT phosphorylation/activation were observed in animals treated with DHA 4 h after MCAo. Activation of other members of the AKT signaling pathway were also observed in DHA treated animals including increases in pS6 at 4 h and pGSK at 24 h. DHA or NPD1 remarkably reduced total and cortical infarct in aged rats. Moreover, we show that in young and aged rats DHA treatment after MCAo potentiates NPD1 biosynthesis. The phosphorylation of p308 AKT or pGSK was not different between groups in aged rats. However, pS6 expression was increased with DHA or NPD1 treatment when compared to vehicle. CONCLUSIONS: We suggest that DHA induces cell survival, modulates the neuroinflammatory response and triggers long term restoration of synaptic circuits. Both DHA and NPD1 elicited remarkable protection in aged animals. Accordingly, activation of DHA signaling might provide benefits in the management of ischemic stroke both acutely as well as long term to limit ensuing disabilities.

  9. Committees versus individuals: an experimental analysis of monetary policy decision-making

    OpenAIRE

    Lombardelli, Clare; Proudman, James; Talbot, James

    2002-01-01

    The results of an experimental analysis of monetary policy decision-making under uncertainty are reported. A large sample of economically literate undergraduate and postgraduate students from the London School of Economics was used to play a simple monetary policy game, both as individuals and in committees of five players. The findings - that groups make better decisions than individuals - accord with previous work by Blinder and Morgan. An attempt was also made to establish why group decisi...

  10. Transcriptomic meta-analysis of multiple sclerosis and its experimental models.

    Directory of Open Access Journals (Sweden)

    Barbara B R Raddatz

    Full Text Available BACKGROUND: Multiple microarray analyses of multiple sclerosis (MS and its experimental models have been published in the last years. OBJECTIVE: Meta-analyses integrate the information from multiple studies and are suggested to be a powerful approach in detecting highly relevant and commonly affected pathways. DATA SOURCES: ArrayExpress, Gene Expression Omnibus and PubMed databases were screened for microarray gene expression profiling studies of MS and its experimental animal models. STUDY ELIGIBILITY CRITERIA: Studies comparing central nervous system (CNS samples of diseased versus healthy individuals with n >1 per group and publically available raw data were selected. MATERIAL AND METHODS: Included conditions for re-analysis of differentially expressed genes (DEGs were MS, myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE in rats, proteolipid protein-induced EAE in mice, Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD, and a transgenic tumor necrosis factor-overexpressing mouse model (TNFtg. Since solely a single MS raw data set fulfilled the inclusion criteria, a merged list containing the DEGs from two MS-studies was additionally included. Cross-study analysis was performed employing list comparisons of DEGs and alternatively Gene Set Enrichment Analysis (GSEA. RESULTS: The intersection of DEGs in MS, EAE, TMEV-IDD, and TNFtg contained 12 genes related to macrophage functions. The intersection of EAE, TMEV-IDD and TNFtg comprised 40 DEGs, functionally related to positive regulation of immune response. Over and above, GSEA identified substantially more differentially regulated pathways including coagulation and JAK/STAT-signaling. CONCLUSION: A meta-analysis based on a simple comparison of DEGs is over-conservative. In contrast, the more experimental GSEA approach identified both, a priori anticipated as well as promising new candidate pathways.

  11. EXPERIMENTAL AND NUMERICAL ANALYSIS OF THE COMPRESSION OF A THIN-WALLED COMPOSITE PLATE

    Directory of Open Access Journals (Sweden)

    Katarzyna Falkowicz

    2016-09-01

    Full Text Available The subject of research is a rectangular plate with a cut-out subjected to regular compression. The plate articulately supported on the short side edges, made of a composite with high strength properties. The study concerned the numerical finite element analysis linear and nonlinear stability of the structure and the experimental validation of the results. The instrument used was a numerical program ABAQUS®.

  12. Brief experimental analysis of stimulus prompts for accurate responding on academic tasks in an outpatient clinic.

    OpenAIRE

    McComas, J J; Wacker, D P; Cooper, L J; Asmus, J M; Richman, D; Stoner, B

    1996-01-01

    Brief multielement designs were used to examine the effects of specific instructional strategies on accuracy of academic performance during outpatient evaluations of 4 children with learning disorders. Instructional strategies that improved accuracy on academic tasks were identified for all participants. These results suggest that the application of experimental analysis methodologies to instructional variables may facilitate the identification of stimulus prompts that are associated with enh...

  13. Theater level operations: modeling ground unit logistical requirements in the Joint Warfare Analysis Experimental Prototype

    OpenAIRE

    Wilk, Thomas J.

    1995-01-01

    This study proposes a methodology for modeling the logistics processes for ground units in the Joint Warfare Analysis Experimental Prototype (JWAEP) simulation. The model structure presented in this research allows for the representation of the consumption. movement, and distribution of supplies within the combat units modeled in JWAEP. Also presented is an architecture to model logistical units in JWAEP Methodologies are presented to model both the "push" and "pull" systems of supply. The su...

  14. Dynamic Behavior of Reciprocating Plunger Pump Discharge Valve Based on Fluid Structure Interaction and Experimental Analysis

    OpenAIRE

    Wang, Guorong; Zhong, Lin; He, Xia; Lei, Zhongqing; Hu, Gang; Li, Rong; Wang, Yunhai

    2015-01-01

    The influence of spring stiffness and valve quality on the motion behaviors of reciprocating plunger pump discharge valves was investigated by fluid structure interaction (FSI) simulation and experimental analysis. The mathematical model of the discharge valve motion of a 2000-fracturing pump was developed and the discrete differential equations were solved according to FSI and results obtained by ANDINA software. Results indicate that spring stiffness influences the maximum lift, the opening...

  15. A comparative theoretical-experimental analysis of settlements of shallow foundations on granular soil

    OpenAIRE

    Davidović Nebojša; Bonić Zoran; Prolović Verka; Mladenović Biljana; Stojić Dragoslav

    2010-01-01

    The paper presents a brief description of experiment within the research project 'Theoretical and experimental analysis of interaction of shallow reinforced concrete foundations and soil for the purpose of improvement of national regulations and implementaation of Eurocode system' where in situ tests of a series of reinforced concrete foundation footing were performed, by loading until failure. As a rule, methods for calculation of shallow foundations settlement on granular soils overestimate...

  16. Numerical analysis of temperature field during hardfacing process and comparison with experimental results

    Directory of Open Access Journals (Sweden)

    Lazić Vukić N.

    2014-01-01

    Full Text Available The three-dimensional transient nonlinear thermal analysis of the hard facing process is performed by using the finite element method. The simulations were executed on the open source Salome platform using the open source finite element solver Code_Aster. The Gaussian double ellipsoid was selected in order to enable greater possibilities for the calculation of the moving heat source. The numerical results were compared with available experimental results.

  17. Experimental determinations of soil copper toxicity to lettuce (Lactuca sativa) growth in highly different copper spiked and aged soils

    DEFF Research Database (Denmark)

    Christiansen, Karen Søgaard; Borggaard, Ole K.; Holm, Peter Engelund;

    2015-01-01

    Accurate knowledge about factors and conditions determining copper (Cu) toxicity in soil is needed for predicting plant growth in various Cu-contaminated soils. Therefore, effects of Cu on growth (biomass production) of lettuce (Lactuca sativa) were tested on seven selected, very different soils...... spiked with Cu and aged for 2 months at 35 °C. Cu toxicity was expressed as pEC50(Cu2+), i.e., the negative logarithm of the EC50(Cu2+) activity to plant growth. The determined pEC50(Cu2+) was significantly and positively correlated with both the analytically readily available soil pH and concentration...... of dissolved organic carbon [DOC] which together could explain 87 % of the pEC50(Cu2+) variation according to the simple equation: pEC50(Cu2+) = 0.98 × pH + 345 × [DOC] − 0.27. Other soil characteristics, including the base cation concentrations (Na+, K+, Ca2+, Mg2+), the cation exchange capacity at soil p...

  18. Results from an experimental trial at a Head Start center to evaluate two meal service approaches to increase fruit and vegetable intake of preschool aged children

    Directory of Open Access Journals (Sweden)

    Harnack Lisa J

    2012-04-01

    Full Text Available Abstract Background Strategies to increase fruit and vegetable consumption of preschool aged children are needed. Objectives Evaluate the independent effects of the following meal service strategies on intake of fruits and vegetables of preschool children: 1. Serving fruits and vegetables in advance of other menu items as part of traditional family style meal service; and 2. Serving meals portioned and plated by providers. Methods Fifty-three preschool aged children completed a randomized crossover experiment conducted at a Head Start center in Minneapolis, MN. Over a six week trial period each of the experimental meal service strategies (serving fruits and vegetable first and serving meals portioned by providers was implemented during lunch service for two one-week periods. Two one-week control periods (traditional family style meal service with all menu items served at once were also included over the six week trial period. Childrens lunch intake was observed as a measure of food and nutrient intake during each experimental condition. Results Fruit intake was significantly higher (p Conclusions Serving fruits in advance of other meal items may be a low cost easy to implement strategy for increasing fruit intake in young children. However, serving vegetables first does not appear to increase vegetable intake. Results provide support for current recommendations for traditional family style meal service in preschool settings.

  19. Analysis and Experimental Verification of a Linear Switched Reluctance Motor Having Special Pole Shape

    Directory of Open Access Journals (Sweden)

    N.C. Lenin

    2010-06-01

    Full Text Available In this paper, the results of a finite element analysis are carried out on new stator geometry of a three phase longitudinal flux Linear Switched Reluctance Motor (LSRM. In the new geometry, pole shoes are affixed to the stator poles. Static and dynamic characteristics for the proposed structure have been highlighted. Motor performance for variable load conditions is discussed. The 2-Dimensional (2-D finite element analysis (FEA and the experimental results of this paper prove that LSRMs are one of the strong candidates for linear propulsion drive

  20. Analysis of the Internal Pressure in Tube Hydroforming and Its Experimental Investigation

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The internal pressure of the process was studied theoretically and experimentally. The external load character and internal stress character of tube hydroforming were discussed first. Then, according to the characters,the function and classification of internal pressure were presented in general. Base on the stress analysis, its effect on the yield criterion and calculation formula were also researched and derived. To verify the correction of the theoretical analysis and derived formula, experiments with different internal pressures were carried out and the result was compared and discussed. It demonstrates that internal pressure plays an important role in tube hydroforming and theory and formula discussed and derived by this paper are feasible in practice.

  1. Comprehensive experimental analysis of nonlinear dynamics in an optically-injected semiconductor laser

    Directory of Open Access Journals (Sweden)

    Kevin Schires

    2011-09-01

    Full Text Available We present the first comprehensive experimental study, to our knowledge, of the routes between nonlinear dynamics induced in a semiconductor laser under external optical injection based on an analysis of time-averaged measurements of the optical and RF spectra and phasors of real-time series of the laser output. The different means of analysis are compared for several types of routes and the benefits of each are discussed in terms of the identification and mapping of the nonlinear dynamics. Finally, the results are presented in a novel audio/video format that describes the evolution of the dynamics with the injection parameters.

  2. Experimental and Numerical Analysis of Screw Fixation in Anterior Cruciate Ligament Reconstruction

    Science.gov (United States)

    Chizari, Mahmoud; Wang, Bin; Snow, Martyn; Barrett, Mel

    2008-09-01

    This paper reports the results of an experimental and finite element analysis of tibial screw fixation in anterior cruciate ligament (ACL) reconstruction. The mechanical properties of the bone and tendon graft are obtained from experiments using porcine bone and bovine tendon. The results of the numerical study are compared with those from mechanical testing. Analysis shows that the model may be used to establish the optimum placement of the tunnel in anterior cruciate ligament reconstruction by predicting mechanical parameters such as stress, strain and displacement at regions in the tunnel wall.

  3. Dynamic analysis of a motorbike engine timing system: Experimental and numerical investigation of the geartrain

    Science.gov (United States)

    Rivola, Alessandro; Troncossi, Marco

    2014-10-01

    The development of high-performance vehicle engines requires advanced investigations in order to provide engineers with proper analysis tools to optimize the system design. The elastodynamic behaviour of the engine powertrain may be critical at high velocities (when the flexibility of the system components can have a major role on the overall performance) with consequences on the valve timing and the transmission of dynamic loads. A thorough numerical/experimental investigation was performed on the timing system of a racing motorbike engine. The timing system included the geartrain, which transmits power from the crankshaft to the camshafts, and the valve train, formed by the camshafts and the cam-follower mechanisms for the valve actuation. An experimental campaign was designed and carried out with the purpose of inspecting the timing system behaviour for different velocities and different design parameters. A numerical model was developed in order to provide a simulation/analysis tool that permits the design optimization of the main system components. The present work focuses on the geartrain elastodynamic analysis, which is the main novelty of a long-lasting activity carried out by the authors in collaborations with Ducati Motor Holding S.p.a. (Bologna, Italy). The experimental campaign, the model development and validation, and some simulation results are reported and discussed.

  4. Computing the modal mass from the state space model in combined experimental-operational modal analysis

    Science.gov (United States)

    Cara, Javier

    2016-05-01

    Modal parameters comprise natural frequencies, damping ratios, modal vectors and modal masses. In a theoretic framework, these parameters are the basis for the solution of vibration problems using the theory of modal superposition. In practice, they can be computed from input-output vibration data: the usual procedure is to estimate a mathematical model from the data and then to compute the modal parameters from the estimated model. The most popular models for input-output data are based on the frequency response function, but in recent years the state space model in the time domain has become popular among researchers and practitioners of modal analysis with experimental data. In this work, the equations to compute the modal parameters from the state space model when input and output data are available (like in combined experimental-operational modal analysis) are derived in detail using invariants of the state space model: the equations needed to compute natural frequencies, damping ratios and modal vectors are well known in the operational modal analysis framework, but the equation needed to compute the modal masses has not generated much interest in technical literature. These equations are applied to both a numerical simulation and an experimental study in the last part of the work.

  5. Analysis of transpacific transport of black carbon during HIPPO-3: implications for black carbon aging

    Directory of Open Access Journals (Sweden)

    Z. Shen

    2014-01-01

    Full Text Available Long-range transport of black carbon (BC is a growing concern as a result of the efficiency of BC in warming the climate and its adverse impact on human health. We study transpacific transport of BC during HIPPO-3 using a combination of inverse modeling and sensitivity analysis. We use the GEOS-Chem chemical transport model and its adjoint to constrain Asian BC emissions and estimate the source of BC over the North Pacific. We find that different sources of BC dominate the transport to the North Pacific during the southbound (29 March 2010 and northbound (13 April 2010 measurements in HIPPO-3. While biomass burning in Southeast Asia (SE contributes about 60% of BC in March, more than 90% of BC comes from fossil fuel and biofuel combustion in East Asia (EA during the April mission. GEOS-Chem simulations generally resolve the spatial and temporal variation of BC concentrations over the North Pacific, but are unable to reproduce the low and high tails of the observed BC distribution. We find that the optimized BC emissions derived from inverse modeling fail to improve model simulations significantly. This failure indicates that uncertainties in BC transport, rather than in emissions, account for the major biases in GEOS-Chem simulations of BC. The aging process, transforming BC from hydrophobic into hydrophilic form, is one of the key factors controlling wet scavenging and remote concentrations of BC. Sensitivity tests on BC aging suggest that the aging time scale of anthropogenic BC from EA is several hours, faster than assumed in most global models, while the aging process of biomass burning BC from SE may occur much slower, with a time scale of a few days. To evaluate the effects of BC aging and wet deposition on transpacific transport of BC, we develop an idealized model of BC transport. We find that the mid-latitude air masses sampled during HIPPO-3 may have experienced a series of precipitation events, particularly near the EA and SE source

  6. Age, period, and cohort analysis of regular dental care behavior and edentulism: A marginal approach

    Directory of Open Access Journals (Sweden)

    Lam Kwok-Fai

    2011-03-01

    Full Text Available Abstract Background To analyze the regular dental care behavior and prevalence of edentulism in adult Danes, reported in sequential cross-sectional oral health surveys by the application of a marginal approach to consider the possible clustering effect of birth cohorts. Methods Data from four sequential cross-sectional surveys of non-institutionalized Danes conducted from 1975-2005 comprising 4330 respondents aged 15+ years in 9 birth cohorts were analyzed. The key study variables were seeking dental care on an annual basis (ADC and edentulism. For the analysis of ADC, survey year, age, gender, socio-economic status (SES group, denture-wearing, and school dental care (SDC during childhood were considered. For the analysis of edentulism, only respondents aged 35+ years were included. Survey year, age, gender, SES group, ADC, and SDC during childhood were considered as the independent factors. To take into account the clustering effect of birth cohorts, marginal logistic regressions with an independent correlation structure in generalized estimating equations (GEE were carried out, with PROC GENMOD in SAS software. Results The overall proportion of people seeking ADC increased from 58.8% in 1975 to 86.7% in 2005, while for respondents aged 35 years or older, the overall prevalence of edentulism (35+ years decreased from 36.4% in 1975 to 5.0% in 2005. Females, respondents in the higher SES group, in more recent survey years, with no denture, and receiving SDC in all grades during childhood were associated with higher probability of seeking ADC regularly (P P P Conclusions With the use of GEE, the potential clustering effect of birth cohorts in sequential cross-sectional oral health survey data could be appropriately considered. The success of Danish dental health policy was demonstrated by a continued increase of regular dental visiting habits and tooth retention in adults because school dental care was provided to Danes in their childhood.

  7. Experimental and Numerical Correlation of Impact of Spherical Projectile for Damage Analysis of Aero Engine Component

    Directory of Open Access Journals (Sweden)

    Anuradha Nayak Majila

    2016-03-01

    Full Text Available Studies the impact response of flat Titanium alloy plate against spherical projectile for damage analysis of aero engine components using experimental and finite element techniques. Compressed gas gun has been used to impart speed to spherical projectile at various impact velocities for damage studies. Crater dimensions (diameter and depth obtained due to impact have been compared with finite element results using commercially available explicit finite element method code LS-DYNA. Strain hardening, high strain rate and thermal softening effect along with damage parameters have been considered using modified Johnson-Cook material model of LS-DYNA. Metallographic analysis has been performed on the indented specimen. This analysis is useful to study failure analysis of gas turbine engine components subjected to domestic object damage of gas turbine engine. Defence Science Journal, Vol. 66, No. 2, March 2016, pp. 193-199, DOI: http://dx.doi.org/10.14429/dsj.66.9130

  8. Residual stress analysis in aged graphite/PMR-15 composites using X-ray diffraction

    Energy Technology Data Exchange (ETDEWEB)

    Benedikt, B. [Los Alamos National Laboratory, Engineering Sciences and Applications Division, Los Alamos, NM 87545 (United States)]. E-mail: bbenedikt@lanl.gov; Lewis, M. [Los Alamos National Laboratory, Engineering Sciences and Applications Division, Los Alamos, NM 87545 (United States); Rangaswamy, P. [Los Alamos National Laboratory, Engineering Sciences and Applications Division, Los Alamos, NM 87545 (United States); Kumosa, M. [Center for Advanced Materials and Structures, Department of Engineering, University of Denver, 2390 South York St., Denver, CO 80208 (United States); Predecki, P. [Center for Advanced Materials and Structures, Department of Engineering, University of Denver, 2390 South York St., Denver, CO 80208 (United States); Kumosa, L. [Center for Advanced Materials and Structures, Department of Engineering, University of Denver, 2390 South York St., Denver, CO 80208 (United States); Gentz, M. [Center for Advanced Materials and Structures, Department of Engineering, University of Denver, 2390 South York St., Denver, CO 80208 (United States)

    2006-04-15

    In this paper, we present and discuss the methodology to monitor average residual stresses in aged high temperature unidirectional and woven graphite fiber/PMR-15 composites. The aging experiments were performed at 315 deg. C for 1170 h in nitrogen and 1064 h in air, respectively. The proposed methodology was based on X-ray diffraction (XRD) strain measurements in embedded crystalline metallic inclusions. The aging experiments performed in nitrogen showed an increasing trend in the measured residual stresses from the embedded inclusions with aging time. In contrast, the aging experiments performed in air showed an increasing trend up to {approx}200 h and then dropped by {approx}40% for both unidirectional and woven composites. To extract the average stresses in the composite matrix from the average stresses in embedded inclusions as determined using XRD, the well-established Eshelby/Mori-Tanaka method was used. In addition, to address the effect of inclusion interactions, we also computed the average stresses in the embedded inclusions by taking into account inclusion interactions within the frame-work of the Eshelby/Mori-Tanaka method. It was shown that the interactions between the inclusions did not significantly disturb the average stresses in the inclusions, thereby validating the Eshelby/Mori-Tanaka method used in our analysis. Finally, we show that for an aging process that does not cause any damage to a composite matrix, a relatively simple computation based on the visco-elastic Eshelby/Mori-Tanaka method is sufficient to determine the average stress field in a composite matrix as compared with the predictions based on classical lamination plate theory (CLPT). However, if significant matrix degradation occurs, the current micromechanical modeling approach would likely produce erroneous results.

  9. Development of advanced methods for analysis of experimental data in diffusion

    Science.gov (United States)

    Jaques, Alonso V.

    There are numerous experimental configurations and data analysis techniques for the characterization of diffusion phenomena. However, the mathematical methods for estimating diffusivities traditionally do not take into account the effects of experimental errors in the data, and often require smooth, noiseless data sets to perform the necessary analysis steps. The current methods used for data smoothing require strong assumptions which can introduce numerical "artifacts" into the data, affecting confidence in the estimated parameters. The Boltzmann-Matano method is used extensively in the determination of concentration - dependent diffusivities, D(C), in alloys. In the course of analyzing experimental data, numerical integrations and differentiations of the concentration profile are performed. These methods require smoothing of the data prior to analysis. We present here an approach to the Boltzmann-Matano method that is based on a regularization method to estimate a differentiation operation on the data, i.e., estimate the concentration gradient term, which is important in the analysis process for determining the diffusivity. This approach, therefore, has the potential to be less subjective, and in numerical simulations shows an increased accuracy in the estimated diffusion coefficients. We present a regression approach to estimate linear multicomponent diffusion coefficients that eliminates the need pre-treat or pre-condition the concentration profile. This approach fits the data to a functional form of the mathematical expression for the concentration profile, and allows us to determine the diffusivity matrix directly from the fitted parameters. Reformulation of the equation for the analytical solution is done in order to reduce the size of the problem and accelerate the convergence. The objective function for the regression can incorporate point estimations for error in the concentration, improving the statistical confidence in the estimated diffusivity matrix

  10. Protocol for an experimental investigation of the roles of oxytocin and social support in neuroendocrine, cardiovascular, and subjective responses to stress across age and gender

    Directory of Open Access Journals (Sweden)

    Block Jason

    2009-12-01

    Full Text Available Abstract Background Substantial empirical evidence has demonstrated that individuals who are socially isolated or have few positive social connections seem to age at a faster rate and have more chronic diseases. Oxytocin is a neurohypophyseal hormone hypothesized to coordinate both the causes and effects of positive social interactions, and may be involved in positive physiological adaptations such as buffering the deleterious effects of stress and promoting resilience. The proposed research will examine whether and how oxytocin influences responses to stress in humans and will consider effects in relation to those of social support. Methods/Design Experimental research will be used to determine whether exogenously administered oxytocin (intranasal influences psychological and physiological outcomes under conditions of stress across gender and age in adulthood. Hypotheses to be tested are: 1 Oxytocin ameliorates the deleterious neuroendocrine, cardiovascular, and subjective effects of stress; 2 Oxytocin and social support have similar and additive stress-buffering effects; 3 Oxytocin effects are stronger in women versus men; and 4 Oxytocin effects are similar across a range of adult ages. Hypotheses will be tested with a placebo-controlled, double-blind study using a sample of healthy men and women recruited from the community. Participants are randomly assigned to receive either oxytocin or placebo. They undergo a social stress manipulation with and without social support (randomly assigned, and outcome measures are obtained at multiple times during the procedure. Discussion Understanding the determinants of healthy aging is a major public health priority and identifying effective measures to prevent or delay the onset of chronic diseases is an important goal. Experimental research on oxytocin, social relationships, and health in adulthood will contribute to the scientific knowledge base for maximizing active life and health expectancy. At

  11. Experimental research and finite element analysis of bridge piers failed in flexure-shear modes

    Institute of Scientific and Technical Information of China (English)

    Sun Zhiguo; Si Bingjun; Wang Dongsheng; Guo Xun

    2008-01-01

    In recent earthquakes,a large number of reinforced concrete (RC) bridges were severely damaged due to mixed flexure-shear failure modes of the bridge piers.An integrated experimental and finite element (FE) analysis study is described in this paper to study the seismic performance of the bridge piers that failed in flexure-shear modes.In the first part,a nonlinear cyclic loading test on six RC bridge piers with circular cross sections is carried out experimentally.The damage states,ductility and energy dissipation parameters,stiffness degradation and shear strength of the piers are studied and compared with each other.The experimental results suggest that all the piers exhibit stable flexural response at displacement ductilities up to four before exhibiting brittle shear failure.The ultimate performance of the piers is dominated by shear capacity due to significant shear cracking,and in some cases,rupturing of spiral bars.In the second part,modeling approaches describing the hysteretic behavior of the piers are investigated by using ANSYS software.A set of models with different parameters is selected and evaluated through comparison with experimental results.The influences of the shear retention coefficients between concrete cracks,the Bauschinger effect in longitudinal reinforcement,the bond-slip relationship between the longitudinal reinforcement and the concrete and the concrete failure surface on the simulated hysteretie curves are discussed.Then,a modified analysis model is presented and its accuracy is verified by comparing the simulated results with experimental ones.This research uses models available in commercial FE codes and is intended for researchers and engineers interested in using ANSYS software to predict the hysteretic behavior of reinforced concrete structures.

  12. Meta-analysis of loci associated with age at natural menopause in African-American women.

    Science.gov (United States)

    Chen, Christina T L; Liu, Ching-Ti; Chen, Gary K; Andrews, Jeanette S; Arnold, Alice M; Dreyfus, Jill; Franceschini, Nora; Garcia, Melissa E; Kerr, Kathleen F; Li, Guo; Lohman, Kurt K; Musani, Solomon K; Nalls, Michael A; Raffel, Leslie J; Smith, Jennifer; Ambrosone, Christine B; Bandera, Elisa V; Bernstein, Leslie; Britton, Angela; Brzyski, Robert G; Cappola, Anne; Carlson, Christopher S; Couper, David; Deming, Sandra L; Goodarzi, Mark O; Heiss, Gerardo; John, Esther M; Lu, Xiaoning; Le Marchand, Loic; Marciante, Kristin; Mcknight, Barbara; Millikan, Robert; Nock, Nora L; Olshan, Andrew F; Press, Michael F; Vaiyda, Dhananjay; Woods, Nancy F; Taylor, Herman A; Zhao, Wei; Zheng, Wei; Evans, Michele K; Harris, Tamara B; Henderson, Brian E; Kardia, Sharon L R; Kooperberg, Charles; Liu, Yongmei; Mosley, Thomas H; Psaty, Bruce; Wellons, Melissa; Windham, Beverly G; Zonderman, Alan B; Cupples, L Adrienne; Demerath, Ellen W; Haiman, Christopher; Murabito, Joanne M; Rajkovic, Aleksandar

    2014-06-15

    Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders. GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated with age at menopause. The relevance of these loci to women of African ancestry has not been previously studied. We therefore sought to uncover additional menopause loci and investigate the relevance of European menopause loci by performing a GWAS meta-analysis in 6510 women with African ancestry derived from 11 studies across the USA. We did not identify any additional loci significantly associated with age at menopause in African Americans. We replicated the associations between six loci and age at menopause (P-value < 0.05): AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8. In addition, associations of 14 loci are directionally consistent with previous reports. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in women of African ancestry residing in USA.

  13. An analysis of the size distribution of Italian firms by age

    Science.gov (United States)

    Cirillo, Pasquale

    2010-02-01

    In this paper we analyze the size distribution of Italian firms by age. In other words, we want to establish whether the way that the size of firms is distributed varies as firms become old. As a proxy of size we use capital. In [L.M.B. Cabral, J. Mata, On the evolution of the firm size distribution: Facts and theory, American Economic Review 93 (2003) 1075-1090], the authors study the distribution of Portuguese firms and they find out that, while the size distribution of all firms is fairly stable over time, the distributions of firms by age groups are appreciably different. In particular, as the age of the firms increases, their size distribution on the log scale shifts to the right, the left tails becomes thinner and the right tail thicker, with a clear decrease of the skewness. In this paper, we perform a similar analysis with Italian firms using the CEBI database, also considering firms’ growth rates. Although there are several papers dealing with Italian firms and their size distribution, to our knowledge a similar study concerning size and age has not been performed yet for Italy, especially with such a big panel.

  14. Transcriptome Analysis on Monocytes from Patients with Neovascular Age-Related Macular Degeneration.

    Science.gov (United States)

    Grunin, Michelle; Hagbi-Levi, Shira-; Rinsky, Batya; Smith, Yoav; Chowers, Itay

    2016-01-01

    Mononuclear phagocytes (MPs), including monocytes/macrophages, play complex roles in age-related macular degeneration (AMD) pathogenesis. We reported altered gene-expression signature in peripheral blood mononuclear cells from AMD patients, and a chemokine receptor signature on AMD monocytes. To obtain comprehensive understanding of MP involvement, particularly in peripheral circulation in AMD, we performed global gene expression analysis in monocytes. We separated monocytes from treatment-naïve neovascular AMD (nvAMD) patients (n = 14) and age-matched controls (n = 15), and performed microarray and bioinformatics analysis. Quantitative real-time PCR was performed on other sets of nvAMD (n = 25), atrophic AMD (n = 21), and controls (n = 28) for validation. This validated microarray genes (like TMEM176A/B and FOSB) tested, including differences between nvAMD and atrophic AMD. We identified 2,165 differentially-expressed genes (P MEME analysis found immune enrichment and specific involved microRNAs. Enrichment of differentially-expressed genes in monocytes was found in retina via SAGE data-mining. These genes were enriched in non-classical vs. classical monocyte subsets (P < 0.05). Therefore, global gene expression analysis in AMD monocytes reveals an altered immune-related signature, further implicating systemic MP activation in AMD. PMID:27374485

  15. Individually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis.

    Science.gov (United States)

    Lehert, P; Villaseca, P; Hogervorst, E; Maki, P M; Henderson, V W

    2015-10-01

    A number of health and lifestyle factors are thought to contribute to cognitive decline associated with age but cannot be easily modified by the individual patient. We identified 12 individually modifiable interventions that can be implemented during midlife or later with the potential to ameliorate cognitive aging. For ten of these, we used PubMed databases for a systematic review of long-duration (at least 6 months), randomized, controlled trials in midlife and older adults without dementia or mild cognitive impairment with objective measures of neuropsychological performance. Using network meta-analysis, we performed a quantitative synthesis for global cognition (primary outcome) and episodic memory (secondary outcome). Of 1038 publications identified by our search strategy, 24 eligible trials were included in the network meta-analysis. Results suggested that the Mediterranean diet supplemented by olive oil and tai chi exercise may improve global cognition, and the Mediterranean diet plus olive oil and soy isoflavone supplements may improve memory. Effect sizes were no more than small (standardized mean differences 0.11-0.22). Cognitive training may have cognitive benefit as well. Most individually modifiable risk factors have not yet been adequately studied. We conclude that some interventions that can be self-initiated by healthy midlife and older adults may ameliorate cognitive aging. PMID:26361790

  16. The probabilistic analysis of language acquisition: Theoretical, computational, and experimental analysis

    CERN Document Server

    Hsu, Anne S; Vitanyi, Paul M B

    2010-01-01

    There is much debate over the degree to which language learning is governed by innate language-specific biases, or acquired through cognition-general principles. Here we examine the probabilistic language acquisition hypothesis on three levels: We outline a novel theoretical result showing that it is possible to learn the exact generative model underlying a wide class of languages, purely from observing samples of the language. We then describe a recently proposed practical framework, which quantifies natural language learnability, allowing specific learnability predictions to be made for the first time. In previous work, this framework was used to make learnability predictions for a wide variety of linguistic constructions, for which learnability has been much debated. Here, we present a new experiment which tests these learnability predictions. We find that our experimental results support the possibility that these linguistic constructions are acquired probabilistically from cognition-general principles.

  17. Updating Finite Element Model of a Wind Turbine Blade Section Using Experimental Modal Analysis Results

    Directory of Open Access Journals (Sweden)

    Marcin Luczak

    2014-01-01

    Full Text Available This paper presents selected results and aspects of the multidisciplinary and interdisciplinary research oriented for the experimental and numerical study of the structural dynamics of a bend-twist coupled full scale section of a wind turbine blade structure. The main goal of the conducted research is to validate finite element model of the modified wind turbine blade section mounted in the flexible support structure accordingly to the experimental results. Bend-twist coupling was implemented by adding angled unidirectional layers on the suction and pressure side of the blade. Dynamic test and simulations were performed on a section of a full scale wind turbine blade provided by Vestas Wind Systems A/S. The numerical results are compared to the experimental measurements and the discrepancies are assessed by natural frequency difference and modal assurance criterion. Based on sensitivity analysis, set of model parameters was selected for the model updating process. Design of experiment and response surface method was implemented to find values of model parameters yielding results closest to the experimental. The updated finite element model is producing results more consistent with the measurement outcomes.

  18. Advanced Laboratory at Texas State University: Error Analysis, Experimental Design, and Research Experience for Undergraduates

    Science.gov (United States)

    Ventrice, Carl

    2009-04-01

    Physics is an experimental science. In other words, all physical laws are based on experimentally observable phenomena. Therefore, it is important that all physics students have an understanding of the limitations of certain experimental techniques and the associated errors associated with a particular measurement. The students in the Advanced Laboratory class at Texas State perform three detailed laboratory experiments during the semester and give an oral presentation at the end of the semester on a scientific topic of their choosing. The laboratory reports are written in the format of a ``Physical Review'' journal article. The experiments are chosen to give the students a detailed background in error analysis and experimental design. For instance, the first experiment performed in the spring 2009 semester is entitled Measurement of the local acceleration due to gravity in the RFM Technology and Physics Building. The goal of this experiment is to design and construct an instrument that is to be used to measure the local gravitational field in the Physics Building to an accuracy of ±0.005 m/s^2. In addition, at least one of the experiments chosen each semester involves the use of the research facilities within the physics department (e.g., microfabrication clean room, surface science lab, thin films lab, etc.), which gives the students experience working in a research environment.

  19. Experimental measurement of energy density in a vibrating plate and comparison with energy finite element analysis

    Science.gov (United States)

    Navazi, H. M.; Nokhbatolfoghahaei, A.; Ghobad, Y.; Haddadpour, H.

    2016-08-01

    In this paper, a new method and formulation is presented for experimental measurement of energy density of high frequency vibrations of a plate. By use of the new proposed method and eight accelerometers, both kinetic and potential energy densities are measured. Also, a computer program is developed based on energy finite element method to evaluate the proposed method. For several points, the results of the developed experimental formulation are compared with those of the energy finite element analysis results. It is observed that, there is a good agreement between experimental results and analyses. Finally, another test setup with reduced accelerometer spacing was prepared and based on the comparison between kinetic and potential results, it is concluded that, the kinetic and potential counterparts of the energy density are equal in high frequency bands. Based on this conclusion, the measurement procedure was upgraded to an efficient and very simple one for high frequency ranges. According to the new test procedure, another experimental measurement was performed and the results had a good agreement with the EFEA results.

  20. Finite Element and Experimental Serviceability Analysis of HSC Beams Strengthened with FRP Sheets

    Directory of Open Access Journals (Sweden)

    Seyed H. Hashemi

    2007-01-01

    Full Text Available The use of externally bonded composite sheets or laminates is by now a diffuse technique to strengthen existing RC structures. However, some aspects of flexural condition still need experimental and numerical analysis; furthermore, especially for serviceability checks, there is a lack of code provisions. Six reinforced high strength concrete (HSC beams strengthened with FRP sheets were fabricated and tested, the finite element (FE models adopted by ANSYS was performed to examine the structural behavior of tested beams was performed. A comparison between the finite element analysis results and the experimental data available on the specimens was made and by using trial and error method, the finite element model was calibrated. Six under-reinforced concrete beams were fabricated and tested to failure. With the exception of the control beam, one or four layers of CFRP were applied to the specimens. The structural response throughout the loading regime was primarily captured in terms of the load deflection behavior. The load deflection plots obtained from numerical study show good agreement with the experimental results. The serviceability characteristics of the test beams were evaluated in terms of the crack width, deflection and stress in steel and concrete. The crack patterns in the beams are also presented.

  1. Polarized light scanning cryomacroscopy, part II: Thermal modeling and analysis of experimental observations.

    Science.gov (United States)

    Feig, Justin S G; Solanki, Prem K; Eisenberg, David P; Rabin, Yoed

    2016-10-01

    This study aims at developing thermal analysis tools and explaining experimental observations made by means of polarized-light cryomacroscopy (Part I). Thermal modeling is based on finite elements analysis (FEA), where two model parameters are extracted from thermal measurements: (i) the overall heat transfer coefficient between the cuvette and the cooling chamber, and (ii) the effective thermal conductivity within the cryoprotective agent (CPA) at the upper part of the cryogenic temperature range. The effective thermal conductivity takes into account enhanced heat transfer due to convection currents within the CPA, creating the so-called Bénard cells. Comparison of experimental results with simulation data indicates that the uncertainty in simulations due to the propagation of uncertainty in measured physical properties exceeds the uncertainty in experimental measurements, which validates the modeling approach. It is shown in this study that while a cavity may form in the upper-center portion of the vitrified CPA, it has very little effect on estimating the temperature distribution within the domain. This cavity is driven by thermal contraction of the CPA, with the upper-center of the domain transitioning to glass last. Finally, it is demonstrated in this study that additional stresses may develop within the glass transition temperature range due to nonlinear behavior of the thermal expansion coefficient. This effect is reported here for the first time in the context of cryobiology, using the capabilities of polarized-light cryomacroscopy.

  2. Experimental investigation and analysis on a concentrating solar collector using linear Fresnel lens

    International Nuclear Information System (INIS)

    A concentrating solar collector based on linear Fresnel lens is investigated experimentally in this paper. This solar collector is expected to acquire a higher thermal efficiency at a relatively high temperature level than the commonly used flat-plate or evacuated tube solar collectors. Experimental results show that the thermal efficiency is about 50% when the conversion temperature (water) is 90 deg. C. The test shows that the indication of lost energy is 0.578 W/m2 K, which is much smaller than that of commonly used evacuated tube solar collector without concentrating. In order to make analysis, a mathematical model for evacuated tube absorber heated by linear Fresnel lens has been built. The validation shows that the model agrees with the experimental data well. The analysis indicates that Fresnel lens collector with evacuated tube absorber has good efficiency (50%) in clear day even when the conversion temperature approaches 200 deg. C. The influence of ambient conditions and the percent of different types of energy loss, etc., are also analyzed.

  3. Experimental and numerical analysis of unsteady behaviour of high efficiency mixed-flow pump

    Directory of Open Access Journals (Sweden)

    Sedlář Milan

    2014-03-01

    Full Text Available This work deals with the experimental and numerical investigation of cavitating and noncavitating flow inside a mixed-flow pump and its influence on performance curves of this pump. The experimental research has been carried out in the closed horizontal loop with the main tank capacity of 35 m3. The loop is equipped with both the compressor and the vacuum pump capable of creating different pressure levels while maintaining constant volume flow rate. Pump investigated in this project has been equipped with transparent windows, which enabled the visualization of flow and cavitation phenomena for a wide range of flow conditions. A comprehensive CFD analysis of tested pump has been done both in the cavitating and noncavitating regimes. The ANSYS CFX commercial CFD package has been used to solve URANS equations together with the Rayleigh-Plesset model and the SST-SAS turbulence model. Both the experimental research and the CFD analysis have provided a good illustration of the flow structures inside the pump and their dynamics for a wide range of flow rates and NPSH values. Flow and cavitation instabilities have been detected at suboptimal flow rates which correspond to increased values of noise and vibrations. The calculated results agree well with the measurements.

  4. Hierarchical Bayesian analysis to incorporate age uncertainty in growth curve analysis and estimates of age from length: Florida manatee (Trichechus manatus) carcasses

    Science.gov (United States)

    Schwarz, L.K.; Runge, M.C.

    2009-01-01

    Age estimation of individuals is often an integral part of species management research, and a number of ageestimation techniques are commonly employed. Often, the error in these techniques is not quantified or accounted for in other analyses, particularly in growth curve models used to describe physiological responses to environment and human impacts. Also, noninvasive, quick, and inexpensive methods to estimate age are needed. This research aims to provide two Bayesian methods to (i) incorporate age uncertainty into an age-length Schnute growth model and (ii) produce a method from the growth model to estimate age from length. The methods are then employed for Florida manatee (Trichechus manatus) carcasses. After quantifying the uncertainty in the aging technique (counts of ear bone growth layers), we fit age-length data to the Schnute growth model separately by sex and season. Independent prior information about population age structure and the results of the Schnute model are then combined to estimate age from length. Results describing the age-length relationship agree with our understanding of manatee biology. The new methods allow us to estimate age, with quantified uncertainty, for 98% of collected carcasses: 36% from ear bones, 62% from length.

  5. FEM Analysis of Spring-backs in Age Forming of Aluminum Alloy Plates

    Institute of Scientific and Technical Information of China (English)

    Huang Lin; Wan Min; Chi Cailou; Ji Xiusheng

    2007-01-01

    The age forming technology, characterized by huge spring-backs, has been developed to manufacture large integral wing-skin panel parts, which necessitates devising a method of predicting spring-backs. A 7B04-T7451 aluminum alloy creep test in tension is accomplished at 155 ℃, and the creep curves are obtained. The material constants of the mechanism-based creep constitutive equations are determined through experiments. The age forming process and the spring-backs of 7B04 aluminum alloy plates are analyzed using the commercial finite element software ABAQUS. The effects of plate thickness and formingtime on spring-backs are researched. The spring-backs decrease with the increase of plate thickness and forming time. The test results verify the reliability of the finite element method (FEM) analysis.

  6. New BPD predicts lung function at school age: Follow-up study and meta-analysis.

    Science.gov (United States)

    Ronkainen, Eveliina; Dunder, Teija; Peltoniemi, Outi; Kaukola, Tuula; Marttila, Riitta; Hallman, Mikko

    2015-11-01

    New treatment practices have improved survival of preterm infants and decreased airway pathology in bronchopulmonary dysplasia (BPD). Our aim was to investigate whether preterm birth, BPD, and the severity of BPD predict lung function in school children that are born in surfactant era. We studied pulmonary function of 88 school-aged children born very preterm (gestational age surfactant treatment. BPD was defined as oxygen dependence for ≥ 28 days and it was severity-graded by oxygen requirement at 36 weeks postmenstrual age (mild, none; moderate, FiO2 = 0.22-0.29; severe, FiO2 ≥ 0.30). Preterm children had lower forced expiratory volume in 1 sec (FEV1 ) 86.4 ± 11.8 versus 94.9 ± 10.1 (mean % predicted ± SD; P < 0.001), and lower diffusion capacity (DLCO) 87.6 ± 13.9 versus 93.7 ± 12.0 (P = 0.005) compared with term controls. BPD group differed in both FEV1 (P = 0.037) and DLCO (P = 0.018) from those without BPD. For meta-analysis, search identified 210 articles. Together with present results, six articles met the inclusion criteria. FEV1 of no BPD, all BPD, and moderate to severe BPD groups differed from that in term controls by -7.4, -10.5, and -17.8%, respectively. According to meta-analysis and follow-up study, the adverse effects of prematurity on pulmonary function are still detectable in school-age. BPD was associated with reductions in both diffusion capacity and spirometry. New interventions are required to document a further decrease in the life-long consequences of prematurity. PMID:25589379

  7. Ageing of passive films on stainless steels in sulfate solutions - XPS analysis

    Energy Technology Data Exchange (ETDEWEB)

    Rossi, A. [Cagliari Univ. (Italy). Dipartimento di Chimica e Technologie Inorganiche e Metallorganiche; Elsener, B. [ETH Hoenggerberg, Zuerich (Switzerland). Inst. of Mater. Chem. and Corrosion

    1995-11-01

    The passivation of stainless steels 1.4301 (18% Cr and 8% Ni) and 1.4529 (20% Cr, 25% Ni and 6% Mo) was studied in neutral 1 M Na{sub 2}SO{sub 4} solutions as a function of polarization time (ageing) at two passivation potential in the passive range by electrochemistry and XPS analysis. The passive current density decreases with time according to a power law indicating higher stability of the passive film after ageing. XPS analyses show that the integral Cr{sup 3+} content in the passive films of the two stainless steels is similar, a slight increase in total film thickness and constant overall composition of the passive film with passivation time is found. ARXPS measurements indicate a bilayer structure and pronounced changes within the passive layer during ageing: Fe{sup 2+} becomes gradually eliminated at longer passivation times. A different ageing behaviour of the 1.4301 (without Mo) and 1.4529 SS (with 6% Mo) is found: the conventional 1.4301 steel shows a more pronounced bilayer structure after 24 h of passivation, but a lower content of hydroxide in the outer layer. On the contrary the passive film of the 1.4529 SS becomes progressively more hydrated during ageing, the amount of Cr(hy) and of OH{sup -} increases with time. The higher pitting resistance of the 1.4529 SS might be explained by the formation of more hydrated (thus more amorphous and flexible) Cr(III)hydroxide passive film, the presence of Mo{sup 6+} and the lower Fe{sup 3+} content in the passive film (reducing pit initiation) together with the marked nickel enrichment at the interface (favouring pit repassivation). (orig.)

  8. Single cell analysis of yeast replicative aging using a new generation of microfluidic device.

    Directory of Open Access Journals (Sweden)

    Yi Zhang

    Full Text Available A major limitation to yeast aging study has been the inability to track mother cells and observe molecular markers during the aging process. The traditional lifespan assay relies on manual micro-manipulation to remove daughter cells from the mother, which is laborious, time consuming, and does not allow long term tracking with high resolution microscopy. Recently, we have developed a microfluidic system capable of retaining mother cells in the microfluidic chambers while removing daughter cells automatically, making it possible to observe fluorescent reporters in single cells throughout their lifespan. Here we report the development of a new generation of microfluidic device that overcomes several limitations of the previous system, making it easier to fabricate and operate, and allowing functions not possible with the previous design. The basic unit of the device consists of microfluidic channels with pensile columns that can physically trap the mother cells while allowing the removal of daughter cells automatically by the flow of the fresh media. The whole microfluidic device contains multiple independent units operating in parallel, allowing simultaneous analysis of multiple strains. Using this system, we have reproduced the lifespan curves for the known long and short-lived mutants, demonstrating the power of the device for automated lifespan measurement. Following fluorescent reporters in single mother cells throughout their lifespan, we discovered a surprising change of expression of the translation elongation factor TEF2 during aging, suggesting altered translational control in aged mother cells. Utilizing the capability of the new device to trap mother-daughter pairs, we analyzed mother-daughter inheritance and found age dependent asymmetric partitioning of a general stress response reporter between mother and daughter cells.

  9. Proliferative response of mouse spermatogonial stem cells after irradiation: a quantitative model analysis of experimental data

    International Nuclear Information System (INIS)

    The testes of CDF1 mice were irradiated with single doses of X-rays ranging from 2-16 Gy. The number of haploid cells in the testis at different times after irradiation (42-350 days) was determined by one-parameter flow cytometry both for irradiated animals and for age-matched controls. Based on literature data on the kinetics of the spermatogenesis in mice, a mathematical model of the (hierarchical) germ tissue was developed. Using this model, the processes of radiation-induced cell loss and subsequent recovery were simulated and free parameters of the model were estimated by fitting the model prediction to the experimental data. One of the aims of the study was to investigate the kinetic behaviour of spermatogonial stem cells and the corresponding control mechanisms. (author)

  10. Continuum of Risk Analysis Methods to Assess Tillage System Sustainability at the Experimental Plot Level

    Directory of Open Access Journals (Sweden)

    Ramesh S. Kanwar

    2011-07-01

    Full Text Available This study applied a broad continuum of risk analysis methods including mean-variance and coefficient of variation (CV statistical criteria, second-degree stochastic dominance (SSD, stochastic dominance with respect to a function (SDRF, and stochastic efficiency with respect to a function (SERF for comparing income-risk efficiency sustainability of conventional and reduced tillage systems. Fourteen years (1990–2003 of economic budget data derived from 35 treatments on 36 experimental plots under corn (Zea mays L. and soybean (Glycine max L. at the Iowa State University Northeast Research Station near Nashua, IA, USA were used. In addition to the other analyses, a visually-based Stoplight or “probability of target value” procedure was employed for displaying gross margin and net return probability distribution information. Mean-variance and CV analysis of the economic measures alone provided somewhat contradictive and inconclusive sustainability rankings, i.e., corn/soybean gross margin and net return showed that different tillage system alternatives were the highest ranked depending on the criterion and type of crop. Stochastic dominance analysis results were similar for SSD and SDRF in that both the conventional and reduced tillage system alternatives were highly ranked depending on the type of crop and tillage system. For the SERF analysis, results were dependent on the type of crop and level of risk aversion. The conventional tillage system was preferred for both corn and soybean for the Stoplight analysis. The results of this study are unique in that they highlight the potential of both traditional stochastic dominance and SERF methods for distinguishing economically sustainable choices between different tillage systems across a range of risk aversion. This study also indicates that the SERF risk analysis method appears to be a useful and easily understood tool to assist farm managers, experimental researchers, and potentially policy

  11. Several experimental applications of gamma ray spectrometry on the analysis of uranium compounds

    International Nuclear Information System (INIS)

    Several experimental applications of gamma ray spectrometry on the analysis of uranium compounds and materials containing it are studied. Special attention is devoted to the correlation between experimental spectra and the decay chains of 235U and 238U contained in the analyzed samples. The following applications are discussed: enrichment determination without using calibration standards, determination of uranium concentration, intensities of the gamma rays emitted by the nuclides present in the decay chains of study and the activity of such nuclides. Because of its importance, detailed discussion about the former one is shown. In addition, preliminary results regarding the emission probabilities of the most important gamma rays of 234mPa are also informed. (author)

  12. Cohesive Laws and Progressive Damage Analysis of Composite Bonded Joints, a Combined Numerical/Experimental Approach

    Science.gov (United States)

    Girolamo, Donato; Davila, Carlos G.; Leone, Frank A.; Lin, Shih-Yung

    2015-01-01

    The results of an experimental/numerical campaign aimed to develop progressive damage analysis (PDA) tools for predicting the strength of a composite bonded joint under tensile loads are presented. The PDA is based on continuum damage mechanics (CDM) to account for intralaminar damage, and cohesive laws to account for interlaminar and adhesive damage. The adhesive response is characterized using standard fracture specimens and digital image correlation (DIC). The displacement fields measured by DIC are used to calculate the J-integrals, from which the associated cohesive laws of the structural adhesive can be derived. A finite element model of a sandwich conventional splice joint (CSJ) under tensile loads was developed. The simulations, in agreement with experimental tests, indicate that the model is capable of predicting the interactions of damage modes that lead to the failure of the joint.

  13. Experimental and numerical analysis of secondary disasters induced by oxygen rich combustion within a tunnel

    Institute of Scientific and Technical Information of China (English)

    Cheng Caixia; Sun Fuchun; Zhou Xinquan; Niu Huiyong; Liang De

    2011-01-01

    Various physical parameters,including gas concentrations (O2,CO,CH4,and H2) and temperatures at different air velocities,were determined for full scale wood fires in the Chongqing Coal Research Institute fire test tunnel.Both experimental measurements and numerical simulations are discussed.The numerical analysis was performed with the computational fluid dynamics software package “FLUENT”.The results show that the experimental data agree with the simulation results.The results verify that Roberts'theory of burning is correct.They also prove that the air velocity is the key factor that determines the type of combustion.Also,it is shown that secondary disasters are unlikely for oxygen rich combustion with a limited fire load.

  14. Numerical and experimental analysis of resistance projection welding of square nuts to sheets

    DEFF Research Database (Denmark)

    Nielsen, Chris Valentin; Zhang, Wenqi; Martins, Paulo A.F.;

    2014-01-01

    as the authors are aware, the first ever three-dimensional simulation of the projection welding of square nuts to sheets by means of finite element analysis. Results are compared with experimental observations and measurements produced by the authors with the aim and objective of assessing the accuracy......Projection welding of nuts to sheets is a widely utilized manufacturing process in the automotive industry. The process entails challenges due the necessity of joining different sheet thicknesses and nut sizes made from dissimilar materials, and due to the fact of experiencing large local...... materials and applications require a new level of understanding of the process by combining finite element modelling and experimentation. This paper draws from the challenge of developing a three-dimensional computer program for electro-thermo-mechanical modeling of resistance welding and presents, as far...

  15. Application of wavelet transform and wigner distribution to experimental data analysis of high temperature plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Yoshimura, Satoru; Okada, Shigefumi; Goto, Seiichi [Osaka Univ., Graduate School of Engineering, Plasma Physics Laboratory, Suita, Osaka (Japan)

    2002-11-01

    Analysis of non-stationary fluctuation signals in high temperature plasmas often requires the simultaneous consideration of their time and frequency information. In this paper, time-frequency analyses of three types of fluctuation signals observed in a tokamak plasma and a field reversed configuration plasma are performed using the wavelet transform and the Wigner distribution. It is shown that better time and frequency resolved spectra of the experimental data can be obtained using the Wigner distribution compared to the wavelet transform. However, artificial spectral peaks called cross-components may be superposed on the real peaks in the Wigner distribution when there are two or more oscillation components in the experimental signal. On the other hand, the wavelet transform has no significant drawbacks such as artificial peaks. These results suggest that each of these two methods has its merits and demerits and we should choose one of them case by case according to the nature of the problems. (author)

  16. Numerical and experimental analysis of the directional stability on crack propagation under biaxial stresses

    Energy Technology Data Exchange (ETDEWEB)

    RodrIguez-MartInez, R; Urriolagoitia-Calderon, G; Urriolagoitia-Sosa, G; Hernandez-Gomez, L H [Instituto Politecnico Nacional Seccion de Estudios de Posgrado e Investigacion (SEPI), Escuela Superior de IngenierIa Mecanica y Electrica (ESIME), Edificio 5. 2do Piso, Unidad Profesional Adolfo Lopez Mateos ' Zacatenco' Col. Lindavista, C.P. 07738, Mexico, D.F. (Mexico); Merchan-Cruz, E A; RodrIguez-Canizo, R G; Sandoval-Pineda, J M, E-mail: rrodriguezm@ipn.m, E-mail: urrio332@hotmail.co, E-mail: guiurri@hotmail.co, E-mail: luishector56@hotmail.co, E-mail: eamerchan@gmail.co, E-mail: ricname@hotmail.co, E-mail: jsandovalp@ipn.m [Instituto Politecnico Nacional Seccion de Estudios de Posgrado e Investigacion (SEPI), Escuela Superior de IngenierIa Mecanica y Electrica (ESIME). Unidad profesional, AZCAPOTZALCO, Av. de las Granjas No. 682, Col. Sta. Catarina Azcapotzalco, C.P. 02550, Mexico D.F. (Mexico)

    2009-08-01

    In this paper, the case of Single Edge Notch (SEN) specimens subject to opening/compressive loading was analyzed; The loads are applied in several ratios to evaluate the influence of the specimen geometry, and the Stress Intensity Factor (SIF) K{sub 1} values on the directional stability of crack propagation. The main purpose of this work is to evaluate the behaviour of the fracture propagation, when modifying the geometry of the SEN specimen and different relationships of load tension/compression are applied. Additionally, the precision of the numerical and experimental analysis is evaluated to determine its reliability when solving this type of problems. The specimens are subjected to biaxial opening/compression loading; both results (numerical and experimental) are compared in order to evaluate the condition of directional stability on crack propagation. Finally, an apparent transition point related to the length of specimens was identified, in which the behaviour of values of SIF changes for different loading ratios.

  17. Experimental and theoretical work for the analysis of creep ratcheting and creep buckling of HTR components

    International Nuclear Information System (INIS)

    At very high temperatures loaded metallic structures undergo inelastic deformations due to creep. The generated creep strains are connected with stress relaxations, stress redistributions and/or progressive deformations. The superposition of primary and secondary stresses may lead to enhanced creep deformations. This phenomenon is known under the name ''creep ratcheting''. The interchange of elastic and creep strains is important for its understanding. Theoretical and experimental work is discussed in this paper. In mainly load controlled situations the behaviour of the material can be described by a nonlinear viscous flow law (Norton power law), where elastic effects can be neglected. The creep collapse of a tube is an example of such a slow flow process. Theoretical calculations based on Hoff's model and on Finite Element Analysis are compared with experimental results. (author). 8 refs, 11 figs, 3 tabs

  18. Chemical analysis of interstitial water in rivers of Centro Experimental Aramar area

    Energy Technology Data Exchange (ETDEWEB)

    Matoso, Erika; Goncalves, Julia Rosa, E-mail: ematoso@hotmail.com [Centro Tecnologico da Marinha (CE/CTM-SP), Ipero, SP (Brazil). Centro Experimental Aramar; Cadore, Solange [Universidade Estadual de Campinas (UNICAMP), Campinas, SP (Brazil). Instituto de Quimica. Departamento de Quimica Analitica

    2013-07-01

    This work presents the results from analysis of samples of interstitial waters for the following chemical parameters: F{sup -}, Cl{sup -}, NO{sub 2}{sup -}, Br{sup -}, NO{sub 3}{sup -}, PO{sub 4}{sup 3-}, SO{sub 4}{sup 2-} by Ionic Chromatography, Na, K by Flame Photometry, Al, Cd, Pb, Cu, Cr, Fe, Mn, Ni, Zn by ICP OES, pH and the biological parameter: toxicity by natural bioluminescent bacterium (Vibrio fischeri) bioassay. The samples were obtained from sediments collected in 6 different sampling locations, in a ratio of 10-km-long from Centro Experimental Aramar (CEA). The rivers were the samples came from were: Ipanema River, Sorocaba River and Ribeirao do Ferro River. The interstitial water was extracted by centrifugation (3000 rpm, 20 min, 4 deg C). Analysis for metal concentrations were carried out after acid digestion and others tests proceeded in the sample after filtration without further treatment. These data will contribute to evaluate the distribution of contaminants and nutrients in these collecting points and this toxicity status. The release of soluble substances from sediments to interstitial water provides one way for bioaccumulation of these compounds and may affect the survival or development of aquatic organisms. The analysis in interstitial water has never been evaluated at this sampling points and the importance of this study is collecting data providing a better knowledge of the hydrological conditions in which Centro Experimental Aramar is located. (author)

  19. A generalized rough set-based information filling technique for failure analysis of thruster experimental data

    Institute of Scientific and Technical Information of China (English)

    Han Shan; Zhu Qiang; Li Jianxun; Chen Lin

    2013-01-01

    Interval-valued data and incomplete data are two key problems for failure analysis of thruster experimental data and have been basically solved by the proposed methods in this paper. Firstly, information data acquired from the simulation and evaluation system formed as interval-valued information system (IIS) is classified by the interval similarity relation. Then, as an improve-ment of the classical rough set, a new kind of generalized information entropy called‘‘H0-informa-tion entropy’’ is suggested for the measurement of uncertainty and the classification ability of IIS. There is an innovative information filling technique using the properties of H0-information entropy to replace missing data by some smaller estimation intervals. Finally, an improved method of failure analysis synthesized by the above achievements is presented to classify the thruster experimental data, complete the information, and extract the failure rules. The feasibility and advantage of this method is testified by an actual application of failure analysis, whose performance is evaluated by the quantification of E-condition entropy.

  20. Comparison of a quasi-3D analysis and experimental performance for three compact radial turbines

    Science.gov (United States)

    Simonyi, P. S.; Boyle, R. J.

    1991-01-01

    An experimental aerodynamic evaluation of three compact radial turbine builds was performed. Two rotors which were 40-50 percent shorter in axial length than conventional state-of-the-art radial rotors were tested. A single nozzle design was used. One rotor was tested with the nozzle at two stagger angle settings. A second rotor was tested with the nozzle in only the closed down setting. Experimental results were compared to predicted results from a quasi-3D inviscid and boundary layer analysis, called MTSB (Meridl/Tsonic/Blayer). This analysis was used to predict turbine performance. It has previously been calibrated only for axial, not radial, turbomachinery. The predicted and measured efficiencies were compared at the design point for the three turbines. At the design points the analysis overpredicted the efficiency by less than 1.7 points. Comparisons were also made at off-design operating points. The results of these comparisons showed the importance of an accurate clearance model for efficiency predictions and also that there are deficiencies in the incidence loss model used.

  1. Development of a short version of the Aging Males' Symptoms scale: Mokken scaling analysis and Rasch analysis.

    Science.gov (United States)

    Lee, Chin-Pang; Chen, Yu; Jiang, Kun-Hao; Chu, Chun-Lin; Chiu, Yu-Wen; Chen, Jiun-Liang; Chen, Ching-Yen

    2016-06-01

    The aim of this study was to develop a psychometrically sound short version of the 17-item Aging Males' Symptoms (AMS) scale using Mokken scale analysis (MSA) and Rasch analysis. We recruited a convenient sample of 1787 men (age: mean (SD) = 43.8 (11.5) years) who visited a men's health polyclinic in Taiwan and completed the AMS scale. The scale was first assessed using MSA. The remaining items were assessed using Rasch analysis. We used a stepwise approach to remove items with χ(2) item statistics and mean square values while monitoring unidimensionality. The item reduction process resulted in a 6-item version of the AMS scale (AMS-6). The AMS-6 scale included a 5-item psychosomatic subscale (original items 1, 4, 5, 8, and 9) and a 1-item sexual subscale (original item 16). Analyses confirmed that the 5-item psychosomatic subscale was a Rasch scale. The AMS-6 correlated well with the AMS scales: the 5-item psychosomatic subscale correlated with the AMS scale (r between 0.50 and 0.92); the 1-item sexual subscale correlated with the sexual subscale of the AMS scale (r = 0.81). A 6-item short form of the AMS scale had satisfactory measurement properties. This version may be useful for estimating psychosomatic and sexual symptoms as well as health-related quality of life with a minimal burden on respondents.

  2. Experimental evidence for segregation of interstitial impurities to defects in a near α titanium alloy during dynamic strain aging using energy filtered transmission electron microscopy

    International Nuclear Information System (INIS)

    Dynamic strain aging was observed in the temperature range between 300 °C and 500 °C in a near α titanium alloy 834 without Silicon (10.38%Al–0.16%Sn–1.86%Zr–0.37%Nb–0.25%Mo–0.27%C–0.30%O–0.006%N, all in at%) tested in the temperature range from room temperature to 500 °C. Electron microscopic investigation of tensile tested samples in an energy filtered transmission electron microscopy provided direct experimental evidence for segregation of interstitial elements like carbon (C) and nitrogen (N) to lath boundaries and dislocation pile ups. On the basis of these results and the comparison of lattice strain generated by different interstitials in α-Ti, it was concluded that segregation of carbon and nitrogen and not oxygen to defects is responsible for DSA in this alloy

  3. Experimental evidence for segregation of interstitial impurities to defects in a near α titanium alloy during dynamic strain aging using energy filtered transmission electron microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Prasad, Kartik, E-mail: kartik@dmrl.drdo.in [Defence Metallurgical Research Laboratory, Kanchanbagh, Hyderabad 500058 (India); School of Engineering Science and Technology, University of Hyderabad, Hyderabad (India); Amrithapandian, S.; Panigrahi, B.K. [Materials Science Group, Indira Gandhi for Centre of Atomic Research, Kalpakkam 603102 (India); Kumar, Vikas [Defence Metallurgical Research Laboratory, Kanchanbagh, Hyderabad 500058 (India); Bhanu Sankara Rao, K. [Mahatma Gandhi Institute of Technology, Gandipet, Hyderabad 500075 (India); Sundararaman, M. [Department of Metallurgical and Materials Engineering, Indian Institute of Technology Madras, Chennai 600036 (India)

    2015-06-25

    Dynamic strain aging was observed in the temperature range between 300 °C and 500 °C in a near α titanium alloy 834 without Silicon (10.38%Al–0.16%Sn–1.86%Zr–0.37%Nb–0.25%Mo–0.27%C–0.30%O–0.006%N, all in at%) tested in the temperature range from room temperature to 500 °C. Electron microscopic investigation of tensile tested samples in an energy filtered transmission electron microscopy provided direct experimental evidence for segregation of interstitial elements like carbon (C) and nitrogen (N) to lath boundaries and dislocation pile ups. On the basis of these results and the comparison of lattice strain generated by different interstitials in α-Ti, it was concluded that segregation of carbon and nitrogen and not oxygen to defects is responsible for DSA in this alloy.

  4. CYP17 MspA1 Polymorphism and Age at Menarche: A Meta-Analysis

    OpenAIRE

    Yu-Fang Pei; Lei Zhang; Hong-Wen Deng; Volodymyr Dvornyk

    2008-01-01

    Objective: Literature data on the effects of CYP17 MspA1 polymorphism on age at menarche (AAM) are inconsistent. To reexamine this controversy, we performed a meta-analysis. Study design: In total 16 studies containing more than 11000 individuals of various ethnicities were selected for the analyses. For 11 case-control studies, odds ratio (OR) was employed to evaluate the risk of late AAM for each study, using homozygote at the wild-type allele as a control group. For the 5 studies with cont...

  5. An experimental-numerical method for comparative analysis of joint prosthesis; Un metodo numerico-experimental para el analisis comparativo de protesis articulares

    Energy Technology Data Exchange (ETDEWEB)

    Claramunt, R.; Rincon, E.; Zubizarreta, V.; Ros, A.

    2001-07-01

    The difficulty that exists in the analysis of mechanical stresses in bones is high due to its complex mechanical and morphological characteristics. This complexity makes generalists modelling and conclusions derived from prototype tests very questionable. In this article a relatively simple comparative analysis systematic method that allow us to establish some behaviour differences in different kind of prosthesis is presented. The method, applicable in principle to any joint problem, is based on analysing perturbations produced in natural stress states of a bone after insertion of a joint prosthesis and combines numerical analysis using a 3-D finite element model and experimental studies based on photoelastic coating and electric extensometry. The experimental method is applied to compare two total hip prosthesis cement-free femoral stems of different philosophy. One anatomic of new generation, being of oblique setting over cancellous bone and the other madreporique of trochantero-diaphyseal support over cortical bone. (Author) 4 refs.

  6. Association between SERPING1 rs2511989 polymorphism and age-related macular degeneration: Meta-analysis

    Institute of Scientific and Technical Information of China (English)

    Yi; Dong; Ze-Dong; Li; Xin-Yu; Fang; Xue-Feng; Shi; Song; Chen; Xin; Tang

    2015-01-01

    AIM: To investigate the association between SERPING1rs2511989(G>A) polymorphism and age-related macular degeneration(AMD).METHODS: A number of electronic databases(up to July 15, 2014) were searched independently by two investigators. A Meta-analysis was performed on the association between SERPING1 rs2511989 polymorphism and AMD. Pooled odds ratios(ORs) with 95% confidence intervals(CIs) were estimated.RESULTS: Eight studies with 16 cohorts consisting of9163 cases and 6813 controls were included in this Metaanalysis. There was no significant association between rs2511989 polymorphism and AMD under all genetic models in overall estimates(A vs G: OR= 0.938, 95%CI =0.858-1.025; AA vs GG:OR =0.871, 95% CI =0.719-1.056;AG vs GG: OR =0.944, 95% CI =0.845-1.054; AA +AG vs GG: OR =0.927, 95% CI =0.823-1.044; AA vs AG +GG:OR =0.890, 95% CI =0.780-1.034). Cumulative Meta-analyses also showed a trend of no association between rs2511989 polymorphism and AMD as information accumulated by year. Subgroup analysis and Meta-regression analysis indicated that age-matching status was the main source of heterogeneity. Sensitivity analysis found the results in overall comparisons and subgroup comparisons of white subjects under the allele model were found to have significantly statistical differences after studies deviating from Hardy-Weinberg equilibrium(HWE) were excluded(overall: OR=0.918, 95%CI = 0.844-0.999, P =0.049; whites: OR =0.901, 95% CI =0.817-0.994, P =0.038). However, the results were notsufficiently robust for further sensitivity analysis and statistical differences disappeared on applying Bonferroni correction(with a significance level set at 0.05/25).CONCLUSION: This Meta-analysis indicates that SERPING1 rs2511989 polymorphism and AMD tend to have no association with each other. Age matching status is a big confounding factor, and more studies with subtle designs are warranted in future.

  7. The use of experimental data in an MTR-type nuclear reactor safety analysis

    Science.gov (United States)

    Day, Simon E.

    Reactivity initiated accidents (RIAs) are a category of events required for research reactor safety analysis. A subset of this is unprotected RIAs in which mechanical systems or human intervention are not credited in the response of the system. Light-water cooled and moderated MTR-type ( i.e., aluminum-clad uranium plate fuel) reactors are self-limiting up to some reactivity insertion limit beyond which fuel damage occurs. This characteristic was studied in the Borax and Spert reactor tests of the 1950s and 1960s in the USA. This thesis considers the use of this experimental data in generic MTR-type reactor safety analysis. The approach presented herein is based on fundamental phenomenological understanding and uses correlations in the reactor test data with suitable account taken for differences in important system parameters. Specifically, a semi-empirical approach is used to quantify the relationship between the power, energy and temperature rise response of the system as well as parametric dependencies on void coefficient and the degree of subcooling. Secondary effects including the dependence on coolant flow are also examined. A rigorous curve fitting approach and error assessment is used to quantify the trends in the experimental data. In addition to the initial power burst stage of an unprotected transient, the longer term stability of the system is considered with a stylized treatment of characteristic power/temperature oscillations (chugging). A bridge from the HEU-based experimental data to the LEU fuel cycle is assessed and outlined based on existing simulation results presented in the literature. A cell-model based parametric study is included. The results are used to construct a practical safety analysis methodology for determining reactivity insertion safety limits for a light-water moderated and cooled MTR-type core.

  8. Dental computed tomographic imaging as age estimation: morphological analysis of the third molar of a group of Turkish population.

    Science.gov (United States)

    Cantekin, Kenan; Sekerci, Ahmet Ercan; Buyuk, Suleyman Kutalmis

    2013-12-01

    Computed tomography (CT) is capable of providing accurate and measurable 3-dimensional images of the third molar. The aims of this study were to analyze the development of the mandibular third molar and its relation to chronological age and to create new reference data for a group of Turkish participants aged 9 to 25 years on the basis of cone-beam CT images. All data were obtained from the patients' records including medical, social, and dental anamnesis and cone-beam CT images of 752 patients. Linear regression analysis was performed to obtain regression formulas for dental age calculation with chronological age and to determine the coefficient of determination (r) for each sex. Statistical analysis showed a strong correlation between age and third-molar development for the males (r2 = 0.80) and the females (r2 = 0.78). Computed tomographic images are clinically useful for accurate and reliable estimation of dental ages of children and youth.

  9. Experimental and Exergy Analysis of A Double Pipe Heat Exchanger for Parallel Flow Arrangement

    OpenAIRE

    Parth P. Parekh; Dr.Neeraj K. Chavda

    2014-01-01

    This paper presents For Experimental and Exergy Analysis of a Double Pipe Heat Exchanger for Parallel- flow Arrangement. The Double pipe heat exchanger is one of the Different types of heat exchangers. double-pipe exchanger because one fluid flows inside a pipe and the other fluid flows between that pipe and another pipe that surrounds the first.In a parallel flow, both the hot and cold fluids enter the Heatexchanger at same end andmove in same direction. The present work is taken up to carry...

  10. Analysis of experimentally validated trans-ionospheric attenuation estimates of VLF signals

    OpenAIRE

    İnan, Umran Savaş; Graf, K. L.; Lehtinen, N. G.; Spasojevic, M.; Cohen,M.B; Marshall, R. A.

    2013-01-01

    JOURNAL OF GEOPHYSICAL RESEARCH: SPACE PHYSICS, VOL. 118, 1–13, doi:10.1002/jgra.50228, 2013 Analysis of experimentally validated trans-ionospheric attenuation estimates of VLF signals K. L. Graf,1 N. G. Lehtinen,1 M. Spasojevic,1 M. B. Cohen,1 R. A. Marshall,1 and U. S. Inan1,2 Received 7 February 2013; revised 6 March 2013; accepted 12 March 2013. [1] Accurate models of trans-ionospheric propagation are needed to assess the role of Earth-originating very low frequency (...

  11. Experimental stress analysis for four 24-in. ANSI standard B16.9 tees

    International Nuclear Information System (INIS)

    The experimental stress analysis and low cycle fatigue tests of four tees tested by Combustion Engineering, Inc. (E-E) under subcontract to Union Carbide Nuclear Division are described. These tests are part of the ORNL Design Criteria for Piping and Nozzles Program which is being conducted for the development of design criteria for nuclear power plant service piping components. The test assemblies were fabricated at C-E from commercially obtained ANSI B16.9 tees and matching diameter steel pipes welded to the tees, with suitable and closures and fixtures for applying the loads

  12. Used frying oil biodiesel production: experimental factorial design and multivariate analysis

    Directory of Open Access Journals (Sweden)

    Rosana de Cassia de Souza Schneider

    2009-01-01

    Full Text Available Biodiesel é derivado de fontes renováveis ereduz significativamente as emissões atmosféricas. Pode serobtido de diversos processos, como a alcoolise. Nestetrabalho, o biodiesel foi produzido através da alcoolise doóleo de fritura usado de indústrias de alimentação. Umplanejamento experimental foi utilizado e os produtos dereação foram analisados por cromatografia gasosa (CGespectroscopia na região do infravermelho com acessório dereflexão total atenuada horizontal (IV-HATR e análiseexploratória por análise de componentes principais (PCA eanálise hierárquica de grupos (HCA. De acordo com ascondições analisadas obteve-se alta conversão em ésteresmetílicos. Por IV-HATR, a conversão máxima foi observadaem condições experimentais de temperatura ( 50 e 60°C,concentração de catalisador (0,6 e 1,2% e a 1:8 de relaçãomolar entre óleo e metanol. Também foi possíveldiscriminar por análise quimiométrica, 4 grupos noplanejamento experimental e determinar as melhorescondições para a produção de biodiesel de óleo de friturausado.Abstract Biodiesel is derived from renewable sources and it significantly reduces atmospheric emissions. It can be obtained byseveral processes, such as alcoholysis. In this work, biodiesel was produced through alcoholysis of used frying oil from a cateringbusiness. An experimental factorial design was used and the reaction products were analyzed through gas chromatography (GC,horizontal attenuated total reflection Fourier transform infrared (HATR/FT-IR spectroscopy and exploratory analysis withprincipal component analysis (PCA and hierarchical cluster analysis (HCA. Under the conditions analyzed, a high degree ofconversion to methyl ester was found. As shown by HATR/FT-IR, the maximum conversion was obtained when the experimentalconditions had the temperature ( 50 e 60°C, largest catalyst concentration (0,6 e 1,2% and a 1:8 molar proportion of oil tomethanol. It was possible to discriminate

  13. Steady and unsteady experimental analysis of a turbocharger for automotive applications

    International Nuclear Information System (INIS)

    Highlights: • Steady and unsteady characteristics of a turbocharger are analysed by experimental means. • The steady state characteristic maps are obtained for both the compressor and the turbine. • The validity of the classical adiabatic assumption is questioned. • The compressor efficiency evaluated through the adiabatic assumption may lead to a 5–10% relative error. • The mild and deep compressor surge phenomena have been experimentally investigated. - Abstract: The paper describes the steady and unsteady performance characteristics of a small size turbocharger typically employed in automotive downsized engine applications. The analysis is carried out by experimental means using an innovative hot gas generator system specifically designed for turbocharger testing which is capable of delivering a wide range of flow rates with adequate thermodynamic characteristics. More in detail, the gas generator consists of a medium size direct injection compression ignition Internal Combustion Engine (ICE) feeding the turbine of the test article. To independently set the hot gas mass flow rate and the turbine inlet temperature, the operating parameters of the aforementioned ICE are specified through an electronic control unit in a fully automated manner. Compared to previously presented data [1] (Energy Procedia, vol. 45, pp 1116-1125, 2014), those reported herein have been collected with the help of newly installed equipment and controlling software allowing for the estimation of the thermal power transferred from the turbocharger to the environment. In particular, thanks to a first law analysis, the collected measurements have shown that the algebraic sum of the thermal power transferred to the lubricating oil as well as to the environment is roughly speaking 20–30% of the compressor total enthalpy change per unit time. Moreover, it has been shown that evaluating the compressor efficiency through classical expression based on the adiabatic assumption leads to

  14. Theory analysis and experimental research on on-line contamination detecting technology in hydraulic oil

    Institute of Scientific and Technical Information of China (English)

    YAO Cheng-yu; ZHAO Jing-yi; ZHANG Qi-sheng

    2006-01-01

    A system of on-line contamination detecting in hydraulic oil based on silting principle is accomplished, where, metal filter membrane as detector, solenoid as active force to propel piston to blotter and gain differential pressure, step motor drives the membrane to filtrate and counter-flush, LabVIEW as detecting software platform, oil's contamination detecting indirectly by gauging differential pressure. Based on theory analysis, accomplished is relation between contamination level and differential pressure, realizing polynomial curve fitting, and calibration experiment. Field experiment is simulated in the condition of experimental laboratory, has credible precision and real-time performance, which can popularize to the field of production.

  15. Experimental analysis of the environmental contamination of electrical equipment; Analisis experimental de la contaminacion ambiental en equipos electricos

    Energy Technology Data Exchange (ETDEWEB)

    Campillo Ruiz, Maria Teresa; Ponce Velez, Marco Antonio [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1996-12-31

    This paper is a summary of the main causes that originate the contamination problems in insulating materials. This as the result of different studies performed in experimental testing stations, as well as in transmission, distribution and laboratory power lines by the Departamento de Materiales of the Instituto de Investigaciones Electricas (IIE). [Espanol] En el presente trabajo se muestra un resumen de los principales factores que originan los problemas de contaminacion en aislamientos. Esto, como resultado de diversos estudios realizados tanto en estaciones de prueba experimentales como en lineas de transmision, distribucion y laboratorio por el Departamento de Materiales del Instituto de Investigaciones Electricas (IIE).

  16. Experimental device, corresponding forward model and processing of the experimental data using wavelet analysis for tomographic image reconstruction applied to eddy current nondestructive evaluation

    International Nuclear Information System (INIS)

    In the context of eddy current non destructive evaluation using a tomographic image reconstruction process, the success of the reconstruction depends not only on the choice of the forward model and of the inversion algorithms, but also on the ability to extract the pertinent data from the raw signal provided by the sensor. We present in this paper, an experimental device designed for imaging purposes, the corresponding forward model, and a pre-processing of the experimental data using wavelet analysis. These three steps implemented with an inversion algorithm, will allow in the future to perform image reconstruction of 3-D flaws. (authors)

  17. Survival analysis of timing of first marriage among women of reproductive age in Nigeria: regional differences.

    Science.gov (United States)

    Adebowale, Stephen A; Fagbamigbe, Francis A; Okareh, Titus O; Lawal, Ganiyu O

    2012-12-01

    Early marriage is common among women in developing countries. Age at first marriage (AFM) has health implication on women and their under-five children. In Nigeria, few studies have explored AFM; the current study was designed to fill the gap. Nigeria Demographic and Health Survey, 2008 dataset on married women aged 15-49 (N = 24,986) was used. Chi-square, OLS regression and Cox proportional hazard models were used in the analysis. The mean AFM was 17.8 +/- 4.8 years and significant difference existed between the mean AFM of women in the North (16.0 +/- 3.6) and South (20.4 +/- 5.0) (p marriage (p marriage was more common in all the regions in the North than the South and the hazard was highest in the North West and North East. Women who reside in rural area (H.R = 1.15; C.I = 1.11-1.18) married early than their counterparts in the urban area. Age at first marriage was directly related to levels of education (p marriage more common in the North than the South. Education has influence on AFM; therefore, women should have at least secondary education before marriage in Nigeria.

  18. Photoelastic stress analysis assisted evaluation of fracture toughness in hydrothermally aged epoxies

    Directory of Open Access Journals (Sweden)

    G. Pitarresi

    2014-10-01

    Full Text Available The present work has investigated the fracture toughness of a model DGEBA epoxy system subject to Hidro-Thermal aging. A Photoelastic Stress Analysis technique has been implemented, showing the evolution of stresses arising throughout the water uptake process due to the non-uniform swelling of the material. Gravimetric and Dynamic Mechanical Thermal Analyses have further complemented the characterization, showing the onset of plasticization effects with aging. The correlation of all previous characterizations has allowed to conclude that an increase of KIC fracture toughness is obtained at the fully saturated condition. In particular Photoelasticity has also revealed the onset of relevant swelling induced stresses during the first stages of water absorption, leading to an increase of fracture toughness due to compressive stresses settling near the crack tip. A stress free condition is instead reestablished at the later stages of absorption, suggesting that the increased toughness of the saturated material is an effect of the modifications induced by aging on the polymer structure.

  19. Experimental and theoretical analyses of the age-dependent large-strain behavior of Sylgard 184 (10:1) silicone elastomer.

    Science.gov (United States)

    Hopf, R; Bernardi, L; Menze, J; Zündel, M; Mazza, E; Ehret, A E

    2016-07-01

    The commercial polydimethysiloxane elastomer Sylgard(®) 184 with mixing ratio 10:1 is in wide use for biomedical research or fundamental studies of mechanobiology. In this paper, a comprehensive study of the large strain mechanical behavior of this material under multiaxial monotonic and cyclic loads, and its change during the first 26 days after preparation is reported. The equibiaxial stress response studied in inflation experiments reveals a much stiffer and more nonlinear response compared to the uniaxial and pure shear characteristics. The polymer revealed remarkably elastic behavior, in particular, very little dependence on strain rates between 0.3%/s and 11%/s, and on the strain history in cyclic experiments. On the other hand, both the small-strain and large strain nonlinear mechanical characteristics of the elastomer are changing with sample age and the results suggest that this process has not ceased after 26 days. A recent re-interpretation of the well-known Ogden model for incompressible rubber-like materials was applied to rationalize the results and accurate agreement was obtained with the experimental data over all testing configurations and testing times. The change of a single parameter in this model is shown to govern the evolution of the nonlinear material characteristics with sample age, attributed to a continuation of the cross-linking process. Based on a kinetic relation to account for this process over time, the model provided successful predictions of the material behavior even after more than one year.

  20. Mechanism Analysis and Experimental Validation of Employing Superconducting Magnetic Energy Storage to Enhance Power System Stability

    Directory of Open Access Journals (Sweden)

    Xiaohan Shi

    2015-01-01

    Full Text Available This paper investigates the mechanism analysis and the experimental validation of employing superconducting magnetic energy storage (SMES to enhance power system stability. The models of the SMES device and the single-machine infinite-bus (SMIB system with SMES are deduced. Based on the model of the SMIB system with SMES, the action mechanism of SMES on a generator is analyzed. The analysis takes the impact of SMES location and the system operating point into consideration, as well. Based on the mechanism analysis, the P-controller and Q-controller are designed utilizing the phase compensation method to improve the damping of the SMIB system. The influence of factors, such as SMES location, transmission system reactance, the dynamic characteristics of SMES and the system operating point, on the damping improvement of SMES, is investigated through root locus analysis. The simulation results of the SMIB test system verify the analysis conclusions and controller design method. The laboratory results of the 150-kJ/100-kW high-temperature SMES (HT-SMES device validate that the SMES device can effectively enhance the damping, as well as the transient stability of the power system.