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Sample records for age experimental analysis

  1. Mathematical Modelling and Experimental Analysis of Early Age Concrete

    DEFF Research Database (Denmark)

    Hauggaard-Nielsen, Anders Boe

    1997-01-01

    The report deals with mathematical models for concrete at early age. In the hardening process chemical reactions take place and the concrete skeleton is created. The processes changes the moisture content and produces heat. The associated temperature rise gives expansion of the material which may...

  2. Aging in biometrics: an experimental analysis on on-line signature.

    Directory of Open Access Journals (Sweden)

    Javier Galbally

    Full Text Available The first consistent and reproducible evaluation of the effect of aging on dynamic signature is reported. Experiments are carried out on a database generated from two previous datasets which were acquired, under very similar conditions, in 6 sessions distributed in a 15-month time span. Three different systems, representing the current most popular approaches in signature recognition, are used in the experiments, proving the degradation suffered by this trait with the passing of time. Several template update strategies are also studied as possible measures to reduce the impact of aging on the system's performance. Different results regarding the way in which signatures tend to change with time, and their most and least stable features, are also given.

  3. Aging in biometrics: an experimental analysis on on-line signature.

    Science.gov (United States)

    Galbally, Javier; Martinez-Diaz, Marcos; Fierrez, Julian

    2013-01-01

    The first consistent and reproducible evaluation of the effect of aging on dynamic signature is reported. Experiments are carried out on a database generated from two previous datasets which were acquired, under very similar conditions, in 6 sessions distributed in a 15-month time span. Three different systems, representing the current most popular approaches in signature recognition, are used in the experiments, proving the degradation suffered by this trait with the passing of time. Several template update strategies are also studied as possible measures to reduce the impact of aging on the system's performance. Different results regarding the way in which signatures tend to change with time, and their most and least stable features, are also given.

  4. Experimental modal analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ibsen, Lars Bo; Liingaard, M.

    2006-12-15

    This technical report concerns the basic theory and principles for experimental modal analysis. The sections within the report are: Output-only modal analysis software, general digital analysis, basics of structural dynamics and modal analysis and system identification. (au)

  5. Experimental modal analysis

    DEFF Research Database (Denmark)

    Ibsen, Lars Bo; Liingaard, Morten

    This technical report concerns the basic theory and principles for experimental modal analysis. The sections within the report are: Output-only modal analysis software (section 1.1), general digital analysis (section 1.2), basics of structural dynamics and modal analysis (section 1.3) and system ...

  6. Effect of cholecystokinin on experimental neuronal aging

    Institute of Scientific and Technical Information of China (English)

    Xiao-Jiang Sun; Qin-Chi Lu; Yan Cai

    2005-01-01

    AIM: To observe the effect of cholecystokinin (CCK) on lipofusin value, neuronal dendrite and spine ultrastructure, and total cellular protein during the process of experimental neuronal aging.METHODS: Experimental neuronal aging study model was established by NBA2cellular serum-free culture method. By using single irtracellular lipofusin value from microspectrophotometry,morphology of neuronal dendrites and spines from the scanner electron microscopy, and total cellular protein as the indexes of experimental neuronal aging, we observed the effect of CCK8 on the process of experimental neuronal aging.RESULTS: Under the condition of serum-free culture,intracellular fluorescence value (%) increased with the extension of culture time (1 d 8.51±3.43; 5 d 10.12±3.03;10 d 20.54±10.3; 15 d 36.88±10.49; bP<0.01). When CCK was added to serum-free culture medium, intracellular lipofusin value (%) decreased remarkably after consecutive CCK reaction for 10 and 15 d (control 36.88±10.49; 5 d 32.03±10.01; 10 d 14.37±5.55; 15 d 17.31±4.80; bP<0.01).As the time of serum-free culturing was prolonged, the number of neuronal dendrite and spine cells decreased.The later increased in number when CCK8 was added. CCK8 could improve the total cellular protein in the process of experimental neuronal aging.CONCLUSION: CCK8 may prolong the process of experimental neuronal aging by maintaining the structure and the number of neuronal dendrite and spine cells and changing the total cellular protein.

  7. Experimental evolution of aging in a bacterium

    Directory of Open Access Journals (Sweden)

    Stearns Stephen C

    2007-07-01

    Full Text Available Abstract Background Aging refers to a decline in reproduction and survival with increasing age. According to evolutionary theory, aging evolves because selection late in life is weak and mutations exist whose deleterious effects manifest only late in life. Whether the assumptions behind this theory are fulfilled in all organisms, and whether all organisms age, has not been clear. We tested the generality of this theory by experimental evolution with Caulobacter crescentus, a bacterium whose asymmetric division allows mother and daughter to be distinguished. Results We evolved three populations for 2000 generations in the laboratory under conditions where selection was strong early in life, but very weak later in life. All populations evolved faster growth rates, mostly by decreasing the age at first division. Evolutionary changes in aging were inconsistent. The predominant response was the unexpected evolution of slower aging, revealing the limits of theoretical predictions if mutations have unanticipated phenotypic effects. However, we also observed the spread of a mutation causing earlier aging of mothers whose negative effect was reset in the daughters. Conclusion Our results confirm that late-acting deleterious mutations do occur in bacteria and that they can invade populations when selection late in life is weak. They suggest that very few organisms – perhaps none- can avoid the accumulation of such mutations over evolutionary time, and thus that aging is probably a fundamental property of all cellular organisms.

  8. Rotifers as experimental tools for investigating aging

    Science.gov (United States)

    Snell, Terry W.; Johnston, Rachel K.; Gribble, Kristin E.; Mark Welch, David B.

    2015-01-01

    Comparative biogerontology has much to contribute to the study of aging. A broad range of aging rates have evolved to meet environmental challenges, and understanding these adaptations can produce valuable insights into aging. The supra Phylum Lophotrochozoa is particularly understudied and has several groups that have intriguing patterns of aging. Members of the Lophotrochozoan phylum Rotifera are particularly useful for aging studies because cohort life tables can be conducted with them easily, and biochemical and genomic tools are available for examining aging mechanisms. This paper reviews a variety of caloric restriction (CR) regimens, small molecule inhibitors, and dietary supplements that extend rotifer lifespan, as well as important interactions between CR and genotype, antioxidant supplements, and TOR and jun-N-terminal kinase (JNK) pathways, and the use of RNAi to identify key genes involved in modulating the aging response. Examples of how rapamycin and JNK inhibitor exposure keeps mortality rates low during the reproductive phase of the life cycle are presented, and the ease of conducting life table experiments to screen natural products from red algae for life extending effects is illustrated. Finally, experimental evolution to produce longer-lived rotifer individuals is demonstrated, and future directions to determine the genetic basis of aging are discussed. PMID:25642019

  9. Experimental Researches of Blood Stasis and Aging

    Institute of Scientific and Technical Information of China (English)

    王传社; 李顺成; 马治中; 李志新; 蒋文跃

    2001-01-01

    @@It was reported by most physicians of traditional Chinese medicine (TCM) in past dynasties that Deficiency of Zangfu(脏腑), Qi and blood, especially the Kidney deficiency, is closely related with aging, and Chinese drugs for fortifying Kidney also play a main role in anti-aging. Many scholars have recently studied the relationship between aging and the Excess Syndrome, such as blood stasis, stagnation of Phlegm Turbidity and stagnation of Qi, particularly the relationship between blood stasis and aging.

  10. Experimental Researches of Blood Stasis and Aging

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    It was reported by most physicians of traditional Chinese medicine (TCM) in past dynasties that Deficiency of Zangfu(脏腑), Qi and blood, especially the Kidney deficiency, is closely related with aging, and Chinese drugs for fortifying Kidney also play a main role in anti-aging. Many scholars have recently studied the relationship between aging and the Excess Syndrome, such as blood stasis, stagnation of Phlegm Turbidity and stagnation of Qi, particularly the relationship between blood stasis and aging.……

  11. Active Ageing: An Analysis

    Directory of Open Access Journals (Sweden)

    Alina-Cristina Nuta

    2011-10-01

    Full Text Available The problem of ageing is a highly topical for Romania and for European Union. In this framework, to create and implement some strategies for active ageing is an important objective. The international and regional forums set (supported by official statistics that the number of older people growing rapidly. Romania needs some programmes (with labour, social, economic, health care aspects to deal with the demographic changes, programs that will reform the existing working life structures and legislation. Despite the actual pension reform, which tries to close the opportunity of early retirement (by penalizing the total pension flows, or increasing the retirement age, etc., the labour system does not sets some important targets for this area.

  12. Experimental design of natural and accellerated bone and wood ageing

    DEFF Research Database (Denmark)

    Facorellis, Y.; Pournou, A.; Richter, Jane;

    2015-01-01

    This paper presents the experimental design for natural and accelerated ageing of bone and wood samples found in museum conditions that was conceived as part of the INVENVORG (Thales Research Funding Program – NRSF) investigating the effects of the environmental factors on natural organic materials....

  13. Experimental investigation of cyclic hygrothermal aging of hybrid composite

    KAUST Repository

    El Yagoubi, Jalal

    2013-04-05

    This work provides an experimental investigation of the cyclic hygrothermal aging of a hybrid composites. We aimed to propose a general framework in the view to further optimize polymer-based composites. It reports experimental data and relevant observations collected during an aging campaign (up to 2000 cycles) where anhydride-cured epoxy samples as well as composites samples are exposed to environmental conditions. The data gathered during the whole campaign reveals that (1) the polymer displays a non-classical sorption behavior (2) the volume change is correlated to the mass uptake (3) the elastic modulus is correlated to the glass transition temperature. Matrix and interface degradation of the hybrid composite is monitored by means of microstructural observations. © 2013 by the American Institute of Aeronautics and Astronautics, Inc. All rights reserved.

  14. Application of experimental poverty measures to the aged.

    Science.gov (United States)

    Olsen, K A

    1999-01-01

    The U.S. Census Bureau recently released new, experimental measures of poverty based on a National Academy of Sciences (NAS) panel's recommendations. This article examines the effects of the experimental measures on poverty rates among persons aged 65 or older in order to help inform policy debate. Policymakers and analysts use poverty rates to measure the successes and failures of existing programs and to create and defend new policy initiatives. The Census Bureau computes the official rates of poverty using poverty thresholds and definitions of countable income that have changed little since the official poverty measure was adopted in 1965. Amid growing concerns about the adequacy of the official poverty measure, a NAS panel undertook a study of the concepts, methodology, and data needed to measure poverty. The panel concluded in its 1995 report that the current measure no longer provides an accurate picture of relative rates of poverty for different groups in the population or of changes in poverty over time. The panel recommended changes in establishing the poverty thresholds, defining family resources, and obtaining the required data. The Census Bureau report shows how estimated levels of poverty would differ from the official level as specific recommendations of the NAS panel are implemented individually and how estimated trends would differ when many recommendations are implemented simultaneously. It computes nonstandardized and standardized poverty rates. (The latter constrains the overall poverty rate under the experimental measures to match the official rate.) This article reports poverty rates that have not been standardized and provides considerably more detail than the Census report about the effects of the experimental measures on poverty among the aged. It examines the effects of changing the poverty thresholds and the items included or excluded from the definition of available resources. It also explores the effects of the experimental measures on

  15. [Age-related characteristics of experimental hypothyroidism in rats].

    Science.gov (United States)

    Hromakova, I A; Zil'berman, S Ts; Konovalenko, O O

    2002-01-01

    The rate of both the synthesis of liver and plasma proteins and RNA-1 and RNA-2 polymerase activities in liver were studied in rats of various ages at experimental hypothyroidism. There has been marked more significant decrease in plasma protein synthesis with age. Both the rate of liver and plasma protein synthesis have been shown to be reduced at experimental hypothyroidism but synthesis of plasma proteins was inhibited to a greater extent. Considerable changes were observed neither in liver and plasma protein synthesis nor in the balance between these two groups of the protein synthesis in old rats. RNA-1 and RNA-2 polymerase activities decreased at hypothyroidism. At all ages the activity of bound enzymes decreased to a larger extent as compared to free forms. The activity of RNA-polymerase 2 was more inhibited than that of RNA-polymerase 1. Reducing protein- and RNA-synthetic processes in the liver with age correlated with the peculiarities of the carbohydrate metabolism: in those young animals with an impaired glucose tolerance the inhibitory effect of hypothyroidism on the intensity of protein and RNA synthesis was more potent as compared to old animals.

  16. Aging and demographic plasticity in response to experimental age structures in honeybees (Apis mellifera L).

    Science.gov (United States)

    Rueppell, Olav; Linford, Robyn; Gardner, Preston; Coleman, Jennifer; Fine, Kari

    2008-08-01

    Honeybee colonies are highly integrated functional units characterized by a pronounced division of labor. Division of labor among workers is mainly age-based, with younger individuals focusing on in-hive tasks and older workers performing the more hazardous foraging activities. Thus, experimental disruption of the age composition of the worker hive population is expected to have profound consequences for colony function. Adaptive demography theory predicts that the natural hive age composition represents a colony-level adaptation and thus results in optimal hive performance. Alternatively, the hive age composition may be an epiphenomenon, resulting from individual life history optimization. We addressed these predictions by comparing individual worker longevity and brood production in hives that were composed of a single age cohort, two distinct age cohorts, and hives that had a continuous, natural age distribution. Four experimental replicates showed that colonies with a natural age composition did not consistently have a higher life expectancy and/or brood production than the single cohort or double cohort hives. Instead, a complex interplay of age structure, environmental conditions, colony size, brood production, and individual mortality emerged. A general trade-off between worker life expectancy and colony productivity was apparent, and the transition from in-hive tasks to foraging was the most significant predictor of worker lifespan irrespective of the colony age structure. We conclude that the natural age structure of honeybee hives is not a colony-level adaptation. Furthermore, our results show that honeybees exhibit pronounced demographic plasticity in addition to behavioral plasticity to react to demographic disturbances of their societies.

  17. Survival analysis of aging aircraft

    Science.gov (United States)

    Benavides, Samuel

    This study pushes systems engineering of aging aircraft beyond the boundaries of empirical and deterministic modeling by making a sharp break with the traditional laboratory-derived corrosion prediction algorithms that have shrouded real-world failures of aircraft structure. At the heart of this problem is the aeronautical industry's inability to be forthcoming in an accurate model that predicts corrosion failures in aircraft in spite of advances in corrosion algorithms or improvements in simulation and modeling. The struggle to develop accurate corrosion probabilistic models stems from a multitude of real-world interacting variables that synergistically influence corrosion in convoluted and complex ways. This dissertation, in essence, offers a statistical framework for the analysis of structural airframe corrosion failure by utilizing real-world data while considering the effects of interacting corrosion variables. This study injects realism into corrosion failures of aging aircraft systems by accomplishing four major goals related to the conceptual and methodological framework of corrosion modeling. First, this work connects corrosion modeling from the traditional, laboratory derived algorithms to corrosion failures in actual operating aircraft. This work augments physics-based modeling by examining the many confounding and interacting variables, such as environmental, geographical and operational, that impact failure of airframe structure. Examined through the lens of censored failure data from aircraft flying in a maritime environment, this study enhances the understanding between the triad of the theoretical, laboratory and real-world corrosion. Secondly, this study explores the importation and successful application of an advanced biomedical statistical tool---survival analysis---to model censored corrosion failure data. This well-grounded statistical methodology is inverted from a methodology that analyzes survival to one that examines failures. Third, this

  18. Age estimation under changes in image quality: An experimental study

    NARCIS (Netherlands)

    Alnajar, F.; Gevers, T.; Karaoglu, S.

    2015-01-01

    In this paper, we investigate the influence of image quality on the performance of aging features. Age estimation systems used or designed a number of aging features to capture the aging cues from the face such as skin texture and wrinkles. These aging cues are sensitive to small changes in the imag

  19. Simulation and experimental analyses of dynamic strain aging of a supersaturated age hardenable aluminum alloy

    Energy Technology Data Exchange (ETDEWEB)

    Anjabin, N. [Department of Materials Science and Engineering, Sharif University of Technology, Tehran 11365-9466 (Iran, Islamic Republic of); Department of Materials Science and Engineering, Pohang University of Science and Technology, Pohang 790-784 (Korea, Republic of); Karimi Taheri, A. [Department of Materials Science and Engineering, Sharif University of Technology, Tehran 11365-9466 (Iran, Islamic Republic of); Kim, H.S., E-mail: hskim@postech.ac.kr [Department of Materials Science and Engineering, Pohang University of Science and Technology, Pohang 790-784 (Korea, Republic of)

    2013-11-15

    In this paper, dynamic strain aging (DSA) behavior in a temperature range of (25–235 °C) and strain rate range of (10{sup −4}–5×10{sup −2} s{sup −1}) was investigated using a supersaturated age hardenable aluminum alloy. It was found that two mechanisms consisted of pinning of solute atoms to mobile dislocations and dynamic precipitation, were responsible for DSA in the testing conditions. The effects of both mechanisms on the macroscopic flow curve were studied using experimental and improved physically based material modeling approaches. It was shown that both phenomena lead to a negative strain rate hardening in the alloy. Dynamic precipitation acting at high temperature results in considerable work hardening and material strengthening. Taking into account these microstructural phenomena, the effects of deformation temperature and strain rate on the macroscopic flow behavior were discussed. The proposed modeling approach could successfully predict the experimental flow curve, possible jerky flow, and the corresponding serration types. Also, the spatial nucleation and propagation of the localized deformation bands along the specimen gauge length were recorded by a digital image correlation method and compared with the proposed model predictions.

  20. Multizone Age-of-Air Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Sherman, Max H.

    2007-07-01

    Age of air is a technique for evaluating ventilation that has been actively used for over 20 years. Age of air quantifies the time it takes for outdoor air to reach a particular location or zone within then indoor environment. Age of air is often also used to quantify the ventilation effectiveness with respect to indoor air quality. In a purely single zone situation this use of age of air is straightforward, but application of age of air techniques in the general multizone environment has not been fully developed. This article looks at expanding those single-zone techniques to the more complicated environment of multizone buildings and in doing so develops further the general concept of age of air. The results of this analysis shows that the nominal age of air as often used cannot be directly used for determining ventilation effectiveness unless specific assumptions are made regarding source distributions.

  1. Aging and Ambiguous ROS. System Genetics Analysis.

    Science.gov (United States)

    Baranov, Vladislav S; Baranova, Elena V

    2017-01-01

    Famous Free Radical Theory (FRT) of aging, the 50th year anniversary of which is celebrated in 2015 postulates a crucial role of Reactive Oxygen Species (ROS) in aging. Still it is the most robust theory of aging as mitochondria ROS production (mtROSp) correlates well with four principal ''rules" of aging being universal, endogenous, progressive, and deleterious. Vast number of experiments in different species prove mutagenic effect of ROS and their carcinogenic properties. So far, FRT stimulates the search of new pharmaceuticals with antioxidant activity. However, some recent experimental data and clinical findings render doubt to ROS as a principal senescence drivers and come in conflict with original version of FRT. Growth stimulating effects of ROS and their modest antitumor properties support these objections. One should remember that FRT is only one of the numerous theories of aging. Molecular mechanisms of senescence involve all living systems and numerous metabolic pathways which are also variable owing to the unique properties of individual genome and unique epigenetic modulations operating throughout the lifetime thus making aging a unique private matter. Universal theory of aging that incorporates and explains all known and suggested mechanisms of aging, is illusive. However, knowledge of unique peculiarities of individual genome, its feasible editing and efficient epigenetic regulation of metabolic pathways give a chance to postpone aging and extend period of active longevity.

  2. Functional recovery in aging mice after experimental stroke.

    Science.gov (United States)

    Manwani, Bharti; Liu, Fudong; Xu, Yan; Persky, Rebecca; Li, Jun; McCullough, Louise D

    2011-11-01

    Aging is a non-modifiable risk factor for stroke. Since not all strokes can be prevented, a major emerging area of research is the development of effective strategies to enhance functional recovery after stroke. However, in the vast majority of pre-clinical stroke studies, the behavioral tests used to assess functional recovery have only been validated for use in young animals, or are designed for rats. Mice are increasingly utilized in stroke models but well validated behavioral tests designed for rats are not necessarily reproducible in mice. We examined a battery of behavioral tests to evaluate functional recovery in an aging murine model of stroke. We found that the vertical pole, hanging wire and open field can accurately assess acute behavioral impairments after stroke in both young and aging male mice, but animals recover rapidly on these tasks. The corner test can accurately and repeatedly differentiate stroke from sham animals up to 30 days post stroke and can be performed reliably in aging mice. Aging male mice had significantly worse behavioral impairment compared to young male mice in the first two weeks after stroke but eventually recovered to the same degree as young mice. In contrast, chronic infarct size, as measured by ipsilateral cerebral atrophy, was significantly lower in aging male mice compared to young male mice. Reactive gliosis, formation of glial scar, and an enhanced innate immune response was seen in the aging brain and may contribute to the delayed behavioral recovery seen in the aging animals.

  3. An Experimental Study on the Aging of Sands

    OpenAIRE

    Baxter, Christopher David Price

    1999-01-01

    There are numerous examples in the literature of time-dependent changes in the proper-ties of sands, or aging effects. Most of these aging effects are of increases in the cone penetration resistance. Time-dependent increases in penetration resistance have been measured in hydraulically placed fills and freshly densified deposits, with the largest in-creases following the use of ground modification techniques such as vibrocompaction, dynamic compaction, and blast densification. It is not kn...

  4. Experimental research on English vowel errors analysis

    Directory of Open Access Journals (Sweden)

    Huang Qiuhua

    2016-01-01

    Full Text Available Our paper analyzed relevant acoustic parameters of people’s speech samples and the results that compared with English standard pronunciation with methods of experimental phonetics by phonetic analysis software and statistical analysis software. Then we summarized phonetic pronunciation errors of college students through the analysis of English pronunciation of vowels, we found that college students’ English pronunciation are easy occur tongue position and lip shape errors during pronounce vowels. Based on analysis of pronunciation errors, we put forward targeted voice training for college students’ English pronunciation, eventually increased the students learning interest, and improved the teaching of English phonetics.

  5. Water age and stream solute dynamics at the Hubbard Brook Experimental Forest (US)

    Science.gov (United States)

    Botter, Gianluca; Benettin, Paolo; McGuire, Kevin; Rinaldo, Andrea

    2016-04-01

    The contribution discusses experimental and modeling results from a headwater catchment at the Hubbard Brook Experimental Forest (New Hampshire, USA) to explore the link between stream solute dynamics and water age. A theoretical framework based on water age dynamics, which represents a general basis for characterizing solute transport at the catchment scale, is used to model both conservative and weathering-derived solutes. Based on the available information about the hydrology of the site, an integrated transport model was developed and used to estimate the relevant hydrochemical fluxes. The model was designed to reproduce the deuterium content of streamflow and allowed for the estimate of catchment water storage and dynamic travel time distributions (TTDs). Within this framework, dissolved silicon and sodium concentration in streamflow were simulated by implementing first-order chemical kinetics based explicitly on dynamic TTD, thus upscaling local geochemical processes to catchment scale. Our results highlight the key role of water stored within the subsoil glacial material in both the short-term and long-term solute circulation at Hubbard Brook. The analysis of the results provided by the calibrated model allowed a robust estimate of the emerging concentration-discharge relationship, streamflow age distributions (including the fraction of event water) and storage size, and their evolution in time due to hydrologic variability.

  6. Optimality models in the age of experimental evolution and genomics.

    Science.gov (United States)

    Bull, J J; Wang, I-N

    2010-09-01

    Optimality models have been used to predict evolution of many properties of organisms. They typically neglect genetic details, whether by necessity or design. This omission is a common source of criticism, and although this limitation of optimality is widely acknowledged, it has mostly been defended rather than evaluated for its impact. Experimental adaptation of model organisms provides a new arena for testing optimality models and for simultaneously integrating genetics. First, an experimental context with a well-researched organism allows dissection of the evolutionary process to identify causes of model failure--whether the model is wrong about genetics or selection. Second, optimality models provide a meaningful context for the process and mechanics of evolution, and thus may be used to elicit realistic genetic bases of adaptation--an especially useful augmentation to well-researched genetic systems. A few studies of microbes have begun to pioneer this new direction. Incompatibility between the assumed and actual genetics has been demonstrated to be the cause of model failure in some cases. More interestingly, evolution at the phenotypic level has sometimes matched prediction even though the adaptive mutations defy mechanisms established by decades of classic genetic studies. Integration of experimental evolutionary tests with genetics heralds a new wave for optimality models and their extensions that does not merely emphasize the forces driving evolution.

  7. Oxidative Damage in the Aging Heart: an Experimental Rat Model

    Science.gov (United States)

    Marques, Gustavo Lenci; Neto, Francisco Filipak; Ribeiro, Ciro Alberto de Oliveira; Liebel, Samuel; de Fraga, Rogério; Bueno, Ronaldo da Rocha Loures

    2015-01-01

    Introduction: Several theories have been proposed to explain the cause of ‘aging’; however, the factors that affect this complex process are still poorly understood. Of these theories, the accumulation of oxidative damage over time is among the most accepted. Particularly, the heart is one of the most affected organs by oxidative stress. The current study, therefore, aimed to investigate oxidative stress markers in myocardial tissue of rats at different ages. Methods: Seventy-two rats were distributed into 6 groups of 12 animals each and maintained for 3, 6, 9, 12, 18 and 24 months. After euthanasia, the heart was removed and the levels of non-protein thiols, lipid peroxidation, and protein carbonylation, as well as superoxide dismutase and catalase activities were determined. Results: Superoxide dismutase, catalase activity and lipid peroxidation were reduced in the older groups of animals, when compared with the younger group. However, protein carbonylation showed an increase in the 12-month group followed by a decrease in the older groups. In addition, the levels of non-protein thiols were increased in the 12-month group and not detected in the older groups. Conclusion: Our data showed that oxidative stress is not associated with aging in the heart. However, an increase in non-protein thiols may be an important factor that compensates for the decrease of superoxide dismutase and catalase activity in the oldest rats, to maintain appropriate antioxidant defenses against oxidative insults. PMID:27006709

  8. Experimental Finite Element Approach for Stress Analysis

    Directory of Open Access Journals (Sweden)

    Ahmet Erklig

    2014-01-01

    Full Text Available This study aims to determining the strain gauge location points in the problems of stress concentration, and it includes both experimental and numerical results. Strain gauges were proposed to be positioned to corresponding locations on beam and blocks to related node of elements of finite element models. Linear and nonlinear cases were studied. Cantilever beam problem was selected as the linear case to approve the approach and conforming contact problem was selected as the nonlinear case. An identical mesh structure was prepared for the finite element and the experimental models. The finite element analysis was carried out with ANSYS. It was shown that the results of the experimental and the numerical studies were in good agreement.

  9. Linking water age and solute dynamics in streamflow at the Hubbard Brook Experimental Forest, NH, USA

    Science.gov (United States)

    Benettin, Paolo; Bailey, Scott W.; Campbell, John L.; Green, Mark B.; Rinaldo, Andrea; Likens, Gene E.; McGuire, Kevin J.; Botter, Gianluca

    2015-11-01

    We combine experimental and modeling results from a headwater catchment at the Hubbard Brook Experimental Forest (HBEF), New Hampshire, USA, to explore the link between stream solute dynamics and water age. A theoretical framework based on water age dynamics, which represents a general basis for characterizing solute transport at the catchment scale, is here applied to conservative and weathering-derived solutes. Based on the available information about the hydrology of the site, an integrated transport model was developed and used to compute hydrochemical fluxes. The model was designed to reproduce the deuterium content of streamflow and allowed for the estimate of catchment water storage and dynamic travel time distributions (TTDs). The innovative contribution of this paper is the simulation of dissolved silicon and sodium concentration in streamflow, achieved by implementing first-order chemical kinetics based explicitly on dynamic TTD, thus upscaling local geochemical processes to catchment scale. Our results highlight the key role of water stored within the subsoil glacial material in both the short-term and long-term solute circulation. The travel time analysis provided an estimate of streamflow age distributions and their evolution in time related to catchment wetness conditions. The use of age information to reproduce a 14 year data set of silicon and sodium stream concentration shows that, at catchment scales, the dynamics of such geogenic solutes are mostly controlled by hydrologic drivers, which determine the contact times between the water and mineral interfaces. Justifications and limitations toward a general theory of reactive solute circulation at catchment scales are discussed.

  10. Dental Videographic Analysis using Digital Age Media

    Science.gov (United States)

    Seth, Karan; Parmar, Siddharaj; Jhawar, Rahul

    2016-01-01

    Aims and objectives This study was to evaluate a new method of smile analysis using videographic and photographic softwares (as in this study Photoshop Elements X, Windows Movie Maker 2012) as primary assessment tools and to develop an index for malocclusion and treatment plan that could be used in assessing severity of maloc-clussion. How to cite this article Agarwal A, Seth K, Parmar S, Jhawar R. Dental Videographic Analysis using Digital Age Media. Int J Clin Pediatr Dent 2016;9(4):355-363. PMID:28127169

  11. Humor, Simplicity, and Experimentation in the Picture Books of Jon Agee.

    Science.gov (United States)

    Cashore, Kristin

    2003-01-01

    Notes that in his 20-year tenure as a picture book artist, Jon Agee, has produced a number of books that greatly vary in appearance. Provides examples of Agee's evolution as an artist while demonstrating his metafictive experimentation with artistic conventions, his play with concepts of reality and impossibility, and his abundant talent for…

  12. Experimental and analysis methods in radiochemical experiments

    Science.gov (United States)

    Cattadori, C. M.; Pandola, L.

    2016-04-01

    Radiochemical experiments made the history of neutrino physics by achieving the first observation of solar neutrinos (Cl experiment) and the first detection of the fundamental pp solar neutrinos component (Ga experiments). They measured along decades the integral νe charged current interaction rate in the exposed target. The basic operation principle is the chemical separation of the few atoms of the new chemical species produced by the neutrino interactions from the rest of the target, and their individual counting in a low-background counter. The smallness of the expected interaction rate (1 event per day in a ˜ 100 ton target) poses severe experimental challenges on the chemical and on the counting procedures. The main aspects related to the analysis techniques employed in solar neutrino experiments are reviewed and described, with a special focus given to the event selection and the statistical data treatment.

  13. Experimental and analysis methods in radiochemical experiments

    Energy Technology Data Exchange (ETDEWEB)

    Cattadori, C.M. [INFN, Milano (Italy); Pandola, L. [Laboratori Nazionali del Sud, INFN, Catania (Italy); Gran Sasso Science Institute, INFN, L' Aquila (Italy)

    2016-04-15

    Radiochemical experiments made the history of neutrino physics by achieving the first observation of solar neutrinos (Cl experiment) and the first detection of the fundamental pp solar neutrinos component (Ga experiments). They measured along decades the integral ν{sub e} charged current interaction rate in the exposed target. The basic operation principle is the chemical separation of the few atoms of the new chemical species produced by the neutrino interactions from the rest of the target, and their individual counting in a low-background counter. The smallness of the expected interaction rate (1 event per day in a ∝ 100 ton target) poses severe experimental challenges on the chemical and on the counting procedures. The main aspects related to the analysis techniques employed in solar neutrino experiments are reviewed and described, with a special focus given to the event selection and the statistical data treatment. (orig.)

  14. Practical Issues in Component Aging Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Dana L. Kelly; Andrei Rodionov; Jens Uwe-Klugel

    2008-09-01

    This paper examines practical issues in the statistical analysis of component aging data. These issues center on the stochastic process chosen to model component failures. The two stochastic processes examined are repair same as new, leading to a renewal process, and repair same as old, leading to a nonhomogeneous Poisson process. Under the first assumption, times between failures can treated as statistically independent observations from a stationary process. The common distribution of the times between failures is called the renewal distribution. Under the second process, the times between failures will not be independently and identically distributed, and one cannot simply fit a renewal distribution to the cumulative failure times or the times between failures. The paper illustrates how the assumption made regarding the repair process is crucial to the analysis. Besides the choice of stochastic process, other issues that are discussed include qualitative graphical analysis and simple nonparametric hypothesis tests to help judge which process appears more appropriate. Numerical examples are presented to illustrate the issues discussed in the paper.

  15. EXPERIMENTAL MODAL ANALYSIS OF VISCO-ELASTICALLY DAMPED STRUCTURES

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    The form of the modal analysis of viscoelastically damped structures is simplified and this simplified form is similar to the form of the modal analysis of linear viscously damped structures. As a result of this simplified form, the experimental modal analysis methods of linear viscously damped structures are applied to the experimental modal analysis of viscoelastically damped structures.

  16. Experimental analysis on photosynthesis of different ages Carya illinoensis%不同树龄美国山核桃光合作用的试验与分析

    Institute of Scientific and Technical Information of China (English)

    吕芳德; 黄菁; 和红晓

    2011-01-01

    The photosynthetic rates of various tree ages Carya illinoensis were investigated from aspects of light response and CO2 response.Meanwhile, the comparisons between bearing branch and unfruitfulness branch were conduced of photosynthetic rate, stomatal conductance, intercellular concentration and transpiration rate.The results show that the middle-aged trees developed fully, had high and stable photosynthetic rate, and better photosynthetic capacity; the comparative results of leaves photosynthetic rate between fruiting branch and unfruitfulness branch indicated that the presence of fruit can promote the photosynthesis rate.%从光响应和CO2响应两个方面研究不同年龄阶段的美国山核桃的光合速率,同时对美国山核桃结果枝和未结果枝的净光合速率、气孔导度、胞间浓度、蒸腾速率进行了比较研究.结果表明:-中龄树发育充分,光合速率大且稳定,光合能力强;果实的生长能促进叶片的光合作用.

  17. Experimental stress does not increase fluctuating asymmetry of broiler chickens at slaughter age.

    Science.gov (United States)

    Van Poucke, E; Van Nuffel, A; Van Dongen, S; Sonck, B; Lens, L; Tuyttens, F A M

    2007-10-01

    Fluctuating asymmetry (FA) is increasingly applied as a putative indicator of animal welfare. Yet its sensitivity to measure welfare of ad libitum-fed farm animals (that presumably have little or no energy allocation constraints) remains largely untested. This study was conducted to examine whether FA is sensitive to experimentally induced stress in broiler chickens and whether effect sizes differ between emotional and physical stressors. Broiler chickens were randomly assigned to emotional stress treatments (pain or frustration), physical stress treatments (wet litter or high temperature and density), or no stress treatment (control). Both physical stressors, unlike the emotional stressors, were known to affect a number of conventional welfare indicators measured at slaughter age. Left-right asymmetry of 14 bilateral traits was measured at slaughter age and compared between treatments. Seven of the 14 bilateral traits proved unsuitable for the study of FA, either due to the presence of directional asymmetry or high measurement error. Fluctuating asymmetry tended to be lowest in the control group and highest in the high temperature and density treatment. However, either when modeling traits as repeated measures at individual broiler level or when performing trait-by-trait analysis, no significant differences between treatments were detected. This negative result may indicate that FA is not a suitable indicator to detect variations of welfare status in fast-growing broiler chickens because of strong past selection for increased BW and improved feed efficiency, which can mask additional stress effects on developmental processes. Alternatively, FA is not a sensitive indicator of welfare in ad libitum-fed animals because of absence of energy allocation constraints. Finally, FA may still be a suitable indicator of welfare under such conditions, but differences between treatments may remain undetected due to insufficient statistical power, which was estimated at 35% for

  18. Determination of factors affecting relapse of vaginitis among reproductive-aged women: An experimental study

    Science.gov (United States)

    Parsapour, Roxana; Majlessi, Fereshteh; Rahimiforoushani, Abbas; Sadeghi, Roya

    2017-01-01

    Introduction Vaginitis is a common problem for women, especially in reproductive-aged women. It is a worldwide health problem with many side effects but could be prevented by a health-promoting lifestyle related to vagina health. The aim of this study was to determine the factors affecting relapse of vaginitis. Methods In this experimental study, 350 reproductive-aged women with vaginitis were selected from 10 health centers in Kermanshah (Iran) during 2015 and were equally included in the intervention and control groups. To collect data, a researcher-created questionnaire, which included sociodemographic and health-promoting lifestyle questions, was used. The educational intervention was performed over 20 sessions, each lasting 25–35 minutes. An intervention group was educated by face-to-face education, pamphlets, phone contacts, text messages, and social media. Another group continued the routine clinic education and treatment without contacting the intervention group. Data were analyzed through chi-square and a logistics regression model using IBM-SPSS version 20. Results The results of the study indicated a significant relation between sociodemographic characteristics such as women and their husbands’ literacy, job, family size, income, area for each member of family, tendency of pregnancy, body mass index (BMI), and caesarean experience (plifestyle dimensions and prevention of vaginitis were identified. Relapse after intervention in the intervention group was 27.7% and 72.3% in the control group. According to the logistic regression analysis, chance for relapse of vaginitis in the group that did not receive intervention was more than the same chance in the intervention group (OR=5.14). Conclusion Health-promoting lifestyle intervention influences prevention of vaginitis. Health-promoting lifestyle, literacy promotion, prevention of caesarian, and obesity are beneficial to improvement in lifestyle dimensions associated with vagina health could be

  19. Experimental cultivations for an evaluation of crop productivity in the Po plain during the Bronze Age

    Directory of Open Access Journals (Sweden)

    Marialetizia Carra

    2012-12-01

    Full Text Available Within the field researches carried out on the Bronze age site of Solarolo, the University of Bologna has started a program of experimental archaeology including the cultivation of ancient cereals. The main aim stress on the reconstruction of ancient economic aspects an particularly the production of crops. The use of several kinds of cereals not modified by modern genetic transformations, similar to those found during the excavations in the Bronze Age site, allows to start a discussion on main topics concerning ancient cultivations during the Bronze Age, supported by methodological, technical and ethnoarchaeological parameters. The scientific method applied along the experimental activities, accompanied by computations of productivity, offers elements to verify the estimations recorded by classical sources.

  20. Host age influence on the intensity of experimental Trichuris suis infection in pigs

    Directory of Open Access Journals (Sweden)

    Pedersen S.

    2002-03-01

    Full Text Available The impact of age-related resistance on the regulation of population dynamics of adult Trichuris suis was investigated in an experimental pig model. Helminth-naive pigs varying in age from five weeks to four years were infected with T. suis to determine susceptibility to infection. Sows had a significantly lower establishment of adult T. suis worms compared with weaner pigs. Adult worm populations were highly overdispersed in both sows and grower pigs contrasted by a more even distribution among weaner pigs. Sows had significantly lower worm fecundities compared to weaner and grower pigs; T. suis from grower pigs, in turn, had reduced fecundity compared to worms in weaner pigs. In conclusion, we provide the first controlled experimental evidence that age-related resistance to T. suis occurs in pigs.

  1. Impact of age on the efficacy of bone marrow mononuclear cell transplantation in experimental stroke

    Directory of Open Access Journals (Sweden)

    Wagner Daniel-Christoph

    2012-08-01

    Full Text Available Abstract Bone marrow-derived mononuclear cells (BM MNC have been effectively used to treat experimental stroke. Most of the preclinical trials have been performed in young and healthy laboratory animals, even though age and hypertension are major risk factors for stroke. To determine the influence of age on the properties of BM MNCs after cerebral ischemia, we compared the efficacy of aged and young BM MNC in an in vitro model of cerebral hypoxia and in an adapted in vivo model of stroke. Human BM MNCs were obtained from healthy young or aged donors and either co-cultured with rat hippocampal slices exposed to oxygen glucose deprivation (OGD, or transplanted intravenously 24 h after permanent middle cerebral artery occlusion in aged (18 months spontaneously hypertensive rats (SHR. Efficacy was examined by quantification of hippocampal cell death, or respectively, by neurofunctional tests and MR investigations. Co-cultivation with young, but not with aged BM MNCs significantly reduced the hippocampal cell death after OGD. Transplantation of both young and old BM MNCs did not reduce functional deficits or ischemic lesion volume after stroke in aged SHR. These results suggest a significant impact of age on the therapeutic efficacy of BM MNCs after cerebral ischemia.

  2. A genome-wide longitudinal transcriptome analysis of the aging model Podospora anserina.

    Directory of Open Access Journals (Sweden)

    Oliver Philipp

    Full Text Available Aging of biological systems is controlled by various processes which have a potential impact on gene expression. Here we report a genome-wide transcriptome analysis of the fungal aging model Podospora anserina. Total RNA of three individuals of defined age were pooled and analyzed by SuperSAGE (serial analysis of gene expression. A bioinformatics analysis identified different molecular pathways to be affected during aging. While the abundance of transcripts linked to ribosomes and to the proteasome quality control system were found to decrease during aging, those associated with autophagy increase, suggesting that autophagy may act as a compensatory quality control pathway. Transcript profiles associated with the energy metabolism including mitochondrial functions were identified to fluctuate during aging. Comparison of wild-type transcripts, which are continuously down-regulated during aging, with those down-regulated in the long-lived, copper-uptake mutant grisea, validated the relevance of age-related changes in cellular copper metabolism. Overall, we (i present a unique age-related data set of a longitudinal study of the experimental aging model P. anserina which represents a reference resource for future investigations in a variety of organisms, (ii suggest autophagy to be a key quality control pathway that becomes active once other pathways fail, and (iii present testable predictions for subsequent experimental investigations.

  3. Aging and fear of crime: an experimental approach to an apparent paradox.

    Science.gov (United States)

    Ziegler, Raphael; Mitchell, David B

    2003-01-01

    Many fear of crime studies have revealed an interesting paradox: Although older adults are less likely to be victims, they report a higher fear of crime than younger adults. In this study, we experimentally manipulated vicarious exposure to crime. Younger (ages 18-29) and older adults (ages 61-78) were randomly assigned to view either a vivid video reenactment of a violent crime or a crime report newscast. Subjects in the violent video condition demonstrated significantly higher fear than did control group participants, but this effect was reliable only for younger adults. The older adults appeared to be unfazed by the violent video, and reported significantly less fear than the younger group. This could not be explained away on the basis of age group differences in neighborhood crime rates, victimization experience, or media exposure. Thus, when greater fear of crime is found in older adults, "old age" per se is not the cause.

  4. Multiple deleterious effects of experimentally aged sperm in a monogamous bird

    Science.gov (United States)

    White, J.; Wagner, R.H.; Helfenstein, F.; Hatch, Shyla A.; Mulard, Hervé; Naves, L.C.; Danchin, E.

    2008-01-01

    Sperm aging is known to be detrimental to reproductive performance. However, this apparently general phenomenon has seldom been studied in an evolutionary context. The negative impact of sperm aging on parental fitness should constitute a strong selective pressure for adaptations to avoid its effects. We studied the impact of sperm aging on black-legged kittiwakes (Rissa tridactyla), a monogamous seabird. Kittiwakes comprise a model system because (i) of evidence that females eject their mates' sperm to prevent fertilization by sperm that would be old and degraded by the time of fertilization and result in reduced reproductive performance and (ii) the lack of extra-pair fertilization in this species makes cryptic female choice an unlikely explanation of postcopulatory sperm ejection by females. We experimentally manipulated the age of the sperm fertilizing kittiwake eggs by fitting males with anti-insemination rings for variable periods of time preceding egg-laying. We found evidence that sperm aging negatively affected four sequential stages of reproduction: fertilization potential, rate of embryonic development, embryonic mortality, and chick condition at hatching. These results may be produced by a continuum of a single process of sperm aging that differentially affects various aspects of development, depending on the degree of damage incurred to the spermatozoa. The marked impact of sperm age on female fitness may thus drive postcopulatory sperm ejection by females. These results provide experimental evidence of deleterious effects of sperm aging on a nondomestic vertebrate, underlining its taxonomic generality and its potential to select for a wide array of adaptations. ?? 2008 by The National Academy of Sciences of the USA.

  5. Emotionality and Aging: A Theoretical and Empirical Analysis.

    Science.gov (United States)

    Schulz, Richard

    1982-01-01

    Discusses semantic issues in defining emotions. Describes important constructs derived from major theories of emotionality. Examines social-psychological and biological changes associated with aging in the context of these theories. Reviews available data on emotionality and aging, describing experimental attempts at manipulating the emotional…

  6. [Thermodynamic theory of biological evolution and aging. Experimental verification of the theory].

    Science.gov (United States)

    Gladyshev, G P

    2000-01-01

    Experimental data confirming original thermodynamic theory of biological evolution and aging are presented. Biological evolution (phylogenesis) and ontogenesis can be easily described within the frames of equilibrium hierarchical thermodynamics on the basis of temporal hierarchies law and the second principle of thermodynamics. The theory explains many facts and suggests new practical proposals in medical and biological science, particularly, in dietology, gerontology, and geriatrics. Application of the temporal hierarchies model to studying living nature offers horizonless possibilities for its understanding.

  7. Pathobiology of aging mice and GEM: background strains and experimental design.

    Science.gov (United States)

    Brayton, C F; Treuting, P M; Ward, J M

    2012-01-01

    The use of induced and spontaneous mutant mice and genetically engineered mice (and combinations thereof) to study cancers and other aging phenotypes to advance improved functional human life spans will involve studies of aging mice. Genetic background contributes to pathology phenotypes and to causes of death as well as to longevity. Increased recognition of expected phenotypes, experimental variables that influence phenotypes and research outcomes, and experimental design options and rationales can maximize the utility of genetically engineered mice (GEM) models to translational research on aging. This review aims to provide resources to enhance the design and practice of chronic and longevity studies involving GEM. C57BL6, 129, and FVB/N strains are emphasized because of their widespread use in the generation of knockout, transgenic, and conditional mutant GEM. Resources are included also for pathology of other inbred strain families, including A, AKR, BALB/c, C3H, C57L, C58, CBA, DBA, GR, NOD.scid, SAMP, and SJL/J, and non-inbred mice, including 4WC, AB6F1, Ames dwarf, B6, 129, B6C3F1, BALB/c,129, Het3, nude, SENCAR, and several Swiss stocks. Experimental strategies for long-term cross-sectional and longitudinal studies to assess causes of or contributors to death, disease burden, spectrum of pathology phenotypes, longevity, and functional healthy life spans (health spans) are compared and discussed.

  8. Design of a management information system for the Shielding Experimental Reactor ageing management

    Energy Technology Data Exchange (ETDEWEB)

    He Jie, E-mail: hejiejoe@163.co [Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 100084 (China); Xu Xianhong [Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 100084 (China)

    2010-01-15

    The problem of nuclear reactor ageing is a topic of increasing importance in nuclear safety recent years. Ageing management is usually implemented for reactors maintenance. In the practice, a large number of data and records need to be processed. However, there are few professional software applications that aid reactor ageing management, especially for research reactors. This paper introduces the design of a new web-based management information system (MIS), named the Shielding Experimental Reactor Ageing Management Information System (SERAMIS). It is an auxiliary means that helps to collect data, keep records, and retrieve information for a research reactor ageing management. The Java2 Enterprise Edition (J2EE) and network database techniques, such as three-tiered model, Model-View-Controller architecture, transaction-oriented operations, and JavaScript techniques, are used in the development of this system. The functionalities of the application cover periodic safety review (PSR), regulatory references, data inspection, and SSCs classification according to ageing management methodology. Data and examples are presented to demonstrate the functionalities. For future work, techniques of data mining will be employed to support decision-making.

  9. Ultrasound Determination of Gestational Age Using Placental Thickness in Female Dogs: An Experimental Study

    Directory of Open Access Journals (Sweden)

    André Luiz Louzada Maldonado

    2012-01-01

    Full Text Available Objective. To verify if the placental thickness allows determining the gestational age, evaluating the correlation between the referred gestational age with the studied one, and the accuracy of the placental thickness measurement (biometry with fetal morphologic parameters in bitches. Methods. The placental thickness of 336 bitches of diverse breeds was evaluated. Bitches were divided in three groups by body weight: small, medium, and big large size. The gestations pregnancies were evaluated by ultrasound from the third week of gestation. An analysis was performed between the mean values of the gestational age obtained of placental thickness by adjustment of curves and the reported gestational age. Student's t-test was applied to compare the mean of reported and placental thickness gestational age. Significance was defined as P<0.05. Results. A positive and statistically significant correlation exists between the placental thickness and gestational age. The expression that presents the best correlation coefficient and explanation was thickness of placenta = 0.021x gestational age −0.314. Conclusion. It is possible to determine the gestational age in relation to the placental thickness measured by ultrasound in bitches with a satisfactory accuracy in relation to fetal morphologic parameters as gestational vesicle, ribs, or kidneys.

  10. Marine Mammal Train Oil Production Methods: Experimental Reconstructions of Norwegian Iron Age Slab-Lined Pits

    Science.gov (United States)

    Nilsen, Gørill

    2016-08-01

    Seal hunting and whaling have played an important part of people's livelihoods throughout prehistory as evidenced by rock carvings, remains of bones, artifacts from aquatic animals and hunting tools. This paper focuses on one of the more elusive resources relating to such activities: marine mammal blubber. Although marine blubber easily decomposes, the organic material has been documented from the Mesolithic Period onwards. Of particular interest in this article are the many structures in Northern Norway from the Iron Age and in Finland on Kökar, Åland, from both the Bronze and Early Iron Ages in which these periods exhibited traits interpreted as being related to oil rendering from marine mammal blubber. The article discusses methods used in this oil production activity based on historical sources, archaeological investigations and experimental reconstruction of Iron Age slab-lined pits from Northern Norway.

  11. CHALLENGES IN DATA INTENSIVE ANALYSIS AT SCIENTIFIC EXPERIMENTAL USER FACILITIES

    Energy Technology Data Exchange (ETDEWEB)

    Kleese van Dam, Kerstin; Li, Dongsheng; Miller, Stephen D.; Cobb, John W.; Green, Mark L.; Ruby, Catherine L.

    2011-12-31

    This chapter will discuss the critical data intensive analysis and visualiza-tion challenges faced by the experimental science community at large scale and laboratory based facilities. The chapter will further highlight initial solutions under development through community efforts and lay out perspectives for the future, such as the potential of more closely linked experimental and computational science approaches, methods to achieve real time analysis capabilities and the challenges and opportunities of data integration across experimental scales, levels of theory and varying techniques.

  12. ANOVA like analysis of cancer death age

    Science.gov (United States)

    Areia, Aníbal; Mexia, João T.

    2016-06-01

    We use ANOVA to study the influence of year, sex, country and location on the average cancer death age. The data used was from the World Health Organization (WHO) files for 1999, 2003, 2007 and 2011. The locations considered were: kidney, leukaemia, melanoma of skin and oesophagus and the countries: Portugal, Norway, Greece and Romania.

  13. Fundamentals of statistical experimental design and analysis

    CERN Document Server

    Easterling, Robert G

    2015-01-01

    Professionals in all areas - business; government; the physical, life, and social sciences; engineering; medicine, etc. - benefit from using statistical experimental design to better understand their worlds and then use that understanding to improve the products, processes, and programs they are responsible for. This book aims to provide the practitioners of tomorrow with a memorable, easy to read, engaging guide to statistics and experimental design. This book uses examples, drawn from a variety of established texts, and embeds them in a business or scientific context, seasoned with a dash of humor, to emphasize the issues and ideas that led to the experiment and the what-do-we-do-next? steps after the experiment. Graphical data displays are emphasized as means of discovery and communication and formulas are minimized, with a focus on interpreting the results that software produce. The role of subject-matter knowledge, and passion, is also illustrated. The examples do not require specialized knowledge, and t...

  14. Histochemical analysis of experimental granulomatous uveitis.

    Science.gov (United States)

    Kristeva, M; Biswas, J; Pararajasegaram, G; Sevanian, A; Rao, N A

    1991-01-01

    We have previously demonstrated the effects of various inhibitors of arachidonic acid metabolism on experimental lens-induced granulomatous uveitis. In the present study, we investigated the effect of these same inhibitors on the expression of lysosomal enzymes at different stages of choroidal inflammation in experimental lens-induced granulomatous uveitis and compared this to the inflammation observed at each stage examined. Lysosomal enzymes such as acid phosphatase, beta-glucuronidase and succinate dehydrogenase are known to be liberated during the maturation of mononuclear phagocytes to epithelioid cell granulomas. Although animals treated with nordihydroguaiaretic acid showed less severe inflammation than did indomethacin-treated or control animals, none of these agents appeared to affect the expression of acid phosphatase and beta-glucuronidase, as determined histochemically. Succinate dehydrogenase could not be detected in any of the eyes examined, even though sections of liver and kidney from these same animals were positive for this enzyme.

  15. Two MIS Analysis Methods: An Experimental Comparison.

    Science.gov (United States)

    Wang, Shouhong

    1996-01-01

    In China, 24 undergraduate business students applied data flow diagrams (DFD) to a mini-case, and 20 used object-oriented analysis (OOA). DFD seemed easier to learn, but after training, those using the OOA method for systems analysis made fewer errors. (SK)

  16. Multifractal age? Multifractal analysis of cardiac interbeat intervals in assessing of healthy aging

    CERN Document Server

    Makowiec, Danuta; Wdowczyk-Szulc, Joanna; Zarczynska-Buchowiecka, Marta; Gruchal, Marcin; Rynkiewicz, Andrzej

    2013-01-01

    24-hour Holter recordings of 124 healthy people at different age are studied. The nocturnal signals of young people reveal the presence of the multiplicative structure. This structure is significantly weaker in diurnal signals and becomes less evident for elderly people. Multifractal analysis allows us to propose qualitative and quantitative methods to estimate the advancement of the aging process for healthy humans.

  17. Forensic age estimation of living individuals: a retrospective analysis.

    Science.gov (United States)

    Santoro, Valeria; De Donno, Antonio; Marrone, Maricla; Campobasso, Carlo Pietro; Introna, Francesco

    2009-12-15

    In recent years, skeletal age determination has become increasingly important in criminal investigations for determining the age of living individuals. To increase diagnostic accuracy, a physical examination, an X-ray examination of the left hand, as well as a dental examination including the determination of the dental status and an X-ray of the dentition should always be performed. In this work, the authors analyze a sample of 52 illegal immigrants who came under their observation in the period from May 1989 to September 2007. A statistical analysis of the results of dental and skeletal age estimations was performed as well as an analysis between the reported and assessed ages. The results showed a significant difference between reported age and assessed biological age (p<0.001); however, no statistical difference was shown between skeletal and assessed dental age (p=0.431).

  18. Experimental analysis of the quantum complementarity principle

    CERN Document Server

    Auccaise, R; Filgueiras, J G; Sarthour, R S; Oliveira, I S; Céleri, L C

    2012-01-01

    One of the milestones of quantum mechanics is Bohr's complementarity principle. It states that a single quantum can exhibit a particle-like \\emph{or} a wave-like behaviour, but never both at the same time. These are mutually exclusive and complementary aspects of the quantum system. This means that we need distinct experimental arrangements in order to measure the particle or the wave nature of a physical system. One of the most known representations of this principle is the single-photon Mach-Zehnder interferometer. When the interferometer is closed an interference pattern is observed (wave aspect of the quantum) while if it is open, the quantum behaves like a particle. Here, using a molecular quantum information processor and employing nuclear magnetic resonant (NMR) techniques, we analyze the quantum version of this principle by means of an interferometer that is in a quantum superposition of being closed and open, and confirm that we can indeed measure both aspects of the system with the same experimental...

  19. Experimental Investigation on Local Air Age and Air Distribution of Stratum Ventilation

    Institute of Scientific and Technical Information of China (English)

    WANG Feng-hao; LI Yuan-bin; LIU Xiao-dong; WANG Xin-ke

    2009-01-01

    Because of the multiple problems on high energy consumption and unbalanced thermal comfort caused by the traditional ventilation system,a new concept of ventilation-stratum ventilation has been proposed,which sends the fresh air to the breathing zone directly.In this paper,the local air distributions of the displace-ment ventilation and the stratum ventilation in a model office were measured.The air ages in the breathing zone for the displacement ventilation and stratum ventilation were compared with the tracer gas concentration decay method.The decay curves of tracer gas concentration for these two ventilation systems in the breathing zonewere obtained, and the air ages were calculated.The experimental results show that the stratum ventilation sys-tem can offer lower air age for four mechanically ventilated cases in the breathing zone,and it can also provide better thermal comfort,which renews the air of breathing zone more quickly and reduces the energy consump-tion in some degree.The experimental investigation provides a theoretical basis for the application of stratum ventilation system.

  20. Experimental analysis of cut welding in aluminium

    DEFF Research Database (Denmark)

    Dorph, Pernille; De Chiffre, Leonardo; Bay, Niels

    1993-01-01

    Cut welding is a newly developed cold pressure welding process. In the present work, an experimental investigation was carried out analyzing the mechanisms involved in cut welding of a block to a strip. Experiments were carried out in technically pure aluminium. The investigation has involved...... tensile testing and metallographic investigations of the welds. The results show that this variant of cut welding is a very reproducible process giving a weld strength equal to 30-40% the strength of the parent material. The experiments have shown that the reason for this relatively low strength...... is an uneven pressure distribution along the weld due to a wave formed during sliding. Attempts to alter the material flow during sliding are presented....

  1. Age-related changes of protein- and RNA-synthetic processes in experimental hyper- and hypothyroidism.

    Science.gov (United States)

    Gromakova, I A; Zilberman, S T; Konovalenko, O A

    2001-07-01

    The rate of liver and plasma protein synthesis and the activity of liver RNA polymerases 1 and 2 were investigated in rats of various age under experimental hyper- and hypothyroidism. The rate of plasma protein synthesis decreased with age more dramatically than that of liver proteins. Hyper- and hypothyroidism exerted opposite effects on protein synthesis in rats: stimulation and inhibition, respectively. The manifestation of these effects was age related. The thyroid status of animals also influenced the balance of protein synthesis. Thyroxin administration caused preferential incorporation of a label into blood plasma proteins. Changes of thyroid status of old animals insignificantly affected the absolute values of the label incorporation into proteins and the ratio of the label incorporation into local and secreted liver proteins. Age-related decrease of total hepatic nuclear RNA-polymerase activity was due to reduction of the template-bound functionally active forms of RNA-polymerases 1 and 2. Administration of thyroxin caused initial redistribution of the enzyme activity between template-bound and free fractions accompanied by the increase of template bound RNA-polymerases. Prolonged hormonal stimulus also caused an increase of free RNA-polymerases, which reflects the increased synthesis of these enzymes. Mecrazolyl administration reduced the activity of RNA-polymerase 1 and 2. All age groups were characterized by preferential reduction of the bound form. RNA-polymerase 2 activity decreased to a greater extent than that of RNA-polymerase 1. The data suggest age-determined reactions of the body to altered thyroid status.

  2. Effect of Reinforcement on Early-Age Concrete Temperature Stress: Preliminary Experimental Investigation and Analytical Simulation

    Directory of Open Access Journals (Sweden)

    Jianda Xin

    2015-01-01

    Full Text Available For concrete under short-term loading, effect of reinforcement on concrete crack resistance capability is usually negligible; however, recent research results show that extension of this viewpoint to concrete under long-term loading (temperature variation may be unsuitable. In order to investigate this phenomenon, this paper presents the experimental and analytical results of early-age reinforced concrete temperature stress development under uniaxial restraint. The experiments were carried out on a temperature stress testing machine (TSTM. Experimental results show that the coupling of reinforcement and concrete creep behavior influenced the concrete temperature stress development, and nearly 16% of concrete stress was reduced in the current research. Moreover, the cracking time of reinforced concrete was also delayed. Finally, based on the principle of superposition, analytical simulations of effect of reinforcement on concrete temperature stress have been performed.

  3. Power Analysis Tutorial for Experimental Design Software

    Science.gov (United States)

    2014-11-01

    Details ............................................................ D-1 Appendix E – JMP Monte Carlo Simulation Script...freedom for error. • In Design Expert, when constructing a design, you are asked for delta and sigma . The default model for power analysis is...Designed Experiments. Third Edition. New York: John Wiley and Sons, 2009. 12. Muthen, Linda, and Bengt Muthen. “How to Use a Monte Carlo Study to

  4. Experimental analysis of nature-nurture interactions.

    Science.gov (United States)

    Wyman, Robert J

    2005-06-01

    The presumed opposition of nature and nurture has been a major concern of western civilization since its beginnings. Christian theologians interpreted Adam and Eve's eating of the forbidden fruit as the origin of an inherited 'original sin'. Saint Augustine explicitly applied the concept to human mental development, arguing that, because of original sin, children are inclined toward evil and education requires physical punishment. For centuries, it was considered parents' moral and religious obligation, not to nurture their children, in our current sense of that word, but to beat the willfulness out of them. 16thC humanists fought back, arguing that "schools have become torture chambers" while it is adults "who corrupt young minds with evil". Locke's (1690) statement that children are born as a 'white paper' was crucial in rejecting the dogma of an inborn (and sinful) nature. The original sin vs. white paper argument merged with another ancient dichotomy: inborn instinct (which controls animal behavior) vs. the reason and free will which humans have. Darwin made the concept of inherited instinct, common to both man and animals, one cornerstone of his theory of evolution. The 20(th)C saw scientists recast the debate as instinct vs. learning, bitterly argued between behaviorists and ethologists. Laboratory experimentation and field observation showed that behavior could develop without learning but also that conditioning paradigms could powerfully mold behavior. The progress of genetics and neurobiology has led to the modern synthesis that neural development, and hence behavior, results from the interdependent action of both heredity and environment.

  5. 3-D Experimental Fracture Analysis at High Temperature

    Energy Technology Data Exchange (ETDEWEB)

    John H. Jackson; Albert S. Kobayashi

    2001-09-14

    T*e, which is an elastic-plastic fracture parameter based on incremental theory of plasticity, was determined numerically and experimentally. The T*e integral of a tunneling crack in 2024-T3 aluminum, three point bend specimen was obtained through a hybrid analysis of moire interferometry and 3-D elastic-plastic finite element analysis. The results were verified by the good agreement between the experimentally and numerically determined T*e on the specimen surface.

  6. The analysis of experimental data obtained from automotives tests

    Science.gov (United States)

    Stoica, R. M.; Radulescu, V. J.; Neagu, D.; Trocan, C.; Copae, I.

    2016-08-01

    The paper highlights the three important and inseparably aspects of the systemic approach of automotives dynamics: taking into account the human-vehicle-field interaction, dealing movement with algorithms specific to system theory and analysis of experimental data with algorithms specific to signals theory.Within the paper, the systemic approach regarding vehicles dynamics is based on experimental data obtained from tests, whereby it is analyzed the movement and there are obtained movement mathematical models through algorithms of systems identification.Likewise, there are shown main analysis methods for experimental data, which uses probability theory, information theory, correlation analysis and variance analysis;in addition, there are highlighted possibilities given by time analysis, frequency analysis and data time-frequency analysis. Identification algorithms and highlighted analysis procedures assure the study of automotives dynamics and fuel saving,by directly using experimental data, or by using mathematical models and applying concepts and algorithms specific to systems theory. Experimental data were obtained by testing automotives with electronic control devices and by using acquisition and storage equipmentsfor data given by the on-board computer and taken from embedded sensors.

  7. Fault Wear and Friction Evolution: Experimental Analysis

    Science.gov (United States)

    Boneh, Y.; Chang, J. C.; Lockner, D. A.; Reches, Z.

    2011-12-01

    Wear is an inevitable product of frictional sliding of brittle rocks as evidenced by the ubiquitous occurrence of fault gouge and slickenside striations. We present here experimental observations designed to demonstrate the relationship between wear and friction and their governing mechanisms. The experiments were conducted with a rotary shear apparatus on solid, ring-shaped rock samples that slipped for displacements up to tens of meters. Stresses, wear and temperature were continuously monitored. We analyzed 86 experiments of Kasota dolomite, Sierra White granite, Pennsylvania quartzite, Karoo gabbro, and Tennessee sandstone at slip velocities ranging from 0.002 to 0.97 m/s, and normal stress from 0.25 to 6.9 MPa. We conducted two types of runs: short slip experiments (slip distance mechanisms; and long slip experiments (slip distance > 3 m) designed to achieve mature wear conditions and to observe the evolution of wear and friction as the fault surfaces evolved. The experiments reveal three wear stages: initial, running-in, and steady-state. The initial stage is characterized by (1) discrete damage striations, the length of which is comparable to total slip , and local pits or plow features; (2) timing and magnitude of fault-normal dilation corresponds to transient changes of normal and shear stresses; and (3) surface roughness increasing with the applied normal stress. We interpret these observations as wear mechanisms of (a) plowing into the fresh rock surfaces; (b) asperity breakage; and (c) asperity climb. The running-in stage is characterized by (1) intense wear-rate over a critical wear distance of Rd = 0.3-2 m; (2) drop of friction coefficient over a weakening distance of Dc = 0.2-4 m; (3) Rd and Dc display positive, quasi-linear relation with each other. We interpret these observations as indicating the organizing of newly-created wear particles into a 'three-body' structure that acts to lubricate the fault (Reches & Lockner, 2010). The steady

  8. Experimental Analysis of Sandstone and Travertine

    Directory of Open Access Journals (Sweden)

    T. Doležel

    2004-01-01

    Full Text Available Sandstone and travertine are sedimentary rocks. The former is clastic, while the latter is sourced by chemical precipitation from hot springs. Their applications in civil engineering structures are mostly influenced by the ability to carry compression loading. A three-point bending experiment is usually used to determine material characteristics. However it does not correspond very well to applicatiosn in structures. For this reason we used a uniaxial compression test to obtain the modulus of elasticity and the stress-strain diagram. To obtain detailed information about the crystalline structure of sandstone and travertine a microscopic analysis wascarried out, using optical microscopy and an EDAX multichannel spectrometer for elementary microanalysis. 

  9. STATISTICAL BAYESIAN ANALYSIS OF EXPERIMENTAL DATA.

    Directory of Open Access Journals (Sweden)

    AHLAM LABDAOUI

    2012-12-01

    Full Text Available The Bayesian researcher should know the basic ideas underlying Bayesian methodology and the computational tools used in modern Bayesian econometrics.  Some of the most important methods of posterior simulation are Monte Carlo integration, importance sampling, Gibbs sampling and the Metropolis- Hastings algorithm. The Bayesian should also be able to put the theory and computational tools together in the context of substantive empirical problems. We focus primarily on recent developments in Bayesian computation. Then we focus on particular models. Inevitably, we combine theory and computation in the context of particular models. Although we have tried to be reasonably complete in terms of covering the basic ideas of Bayesian theory and the computational tools most commonly used by the Bayesian, there is no way we can cover all the classes of models used in econometrics. We propose to the user of analysis of variance and linear regression model.

  10. Functional and structural causes of forests productivity decay with age: experimental analysis of a chrono-sequence of maritime pine stands; Causes fonctionnelles et structurales du declin de productivite des forets avec l'age: analyse experimentale d'une chronosequence de peuplements de pin maritime

    Energy Technology Data Exchange (ETDEWEB)

    Delzon, S.

    2004-06-15

    The aim of this work was to understand the causes of forest growth decline with increasing age. We investigated changes in several eco-physiological parameters in a chrono-sequence of four even-aged maritime pine stands. Above-ground productivity declined by a factor of 2.5 from the youngest to the oldest stands. This decline was explained by a decrease of gross primary production, due to a decline in both stand leaf area and foliar productivity. Our measurements clearly showed a decrease in leaf-specific hydraulic conductance with increasing tree height (50% lower in 30 m trees than in 10 m trees). We also found that needle water potential was maintained above a minimum threshold value of -2.0 MPa independently of tree age and height. This hydraulic homeostasis occurred through a decline in leaf / sapwood area ratio (hydraulic compensation) and a decline in stomatal conductance (physiological compensation). Both the increased investment in non-productive versus productive tissues and stomatal closure may have contributed to the observed decrease in foliar productivity with increasing tree height. Consequently, over-storey transpiration was reduced by a factor of three between the 10-yr and the 91-yr old stands. Nevertheless, our findings suggest that the total ecosystem evaporation remains constant in ageing forests due to an increase in under-storey transpiration, which may counterbalance the decrease in tree transpiration. Photosynthetic capacity also decreased in older stands, mainly through a decline in phosphorus concentration. Our results support the hypothesis that the age-related decline in forest growth is associated with decreased availability of the most limiting resource, this being phosphorus for the maritime Pine chrono-sequence investigated. (author)

  11. Determination of equivalent breast phantoms for different age groups of Taiwanese women: An experimental approach

    Energy Technology Data Exchange (ETDEWEB)

    Dong, Shang-Lung; Chu, Tieh-Chi; Lin, Yung-Chien; Lan, Gong-Yau; Yeh, Yu-Hsiu; Chen, Sharon; Chuang, Keh-Shih [Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101 Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan (China); Department of Radiology, Cheng Hsin General Hospital, 45 Cheng Hsin Street, Pai-Tou District, Taipei 11220, Taiwan (China); Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan (China); Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101 Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan (China)

    2011-07-15

    Purpose: Polymethylmethacrylate (PMMA) slab is one of the mostly used phantoms for studying breast dosimetry in mammography. The purpose of this study was to evaluate the equivalence between exposure factors acquired from PMMA slabs and patient cases of different age groups of Taiwanese women in mammography. Methods: This study included 3910 craniocaudal screen/film mammograms on Taiwanese women acquired on one mammographic unit. The tube loading, compressed breast thickness (CBT), compression force, tube voltage, and target/filter combination for each mammogram were collected for all patients. The glandularity and the equivalent thickness of PMMA were determined for each breast using the exposure factors of the breast in combination with experimental measurements from breast-tissue-equivalent attenuation slabs. Equivalent thicknesses of PMMA to the breasts of Taiwanese women were then estimated. Results: The average {+-} standard deviation CBT and breast glandularity in this study were 4.2 {+-} 1.0 cm and 54% {+-} 23%, respectively. The average equivalent PMMA thickness was 4.0 {+-} 0.7 cm. PMMA slabs producing equivalent exposure factors as in the breasts of Taiwanese women were determined for the age groups 30-49 yr and 50-69 yr. For the 4-cm PMMA slab, the CBT and glandularity values of the equivalent breast were 4.1 cm and 65%, respectively, for the age group 30-49 yr and 4.4 cm and 44%, respectively, for the age group 50-69 yr. Conclusions: The average thickness of PMMA slabs producing the same exposure factors as observed in a large group of Taiwanese women is less than that reported for American women. The results from this study can provide useful information for determining a suitable thickness of PMMA for mammographic dose survey in Taiwan. The equivalence of PMMA slabs and the breasts of Taiwanese women is provided to allow average glandular dose assessment in clinical practice.

  12. Experimental Modal Analysis of a Flat Plate Subjected To Vibration

    Directory of Open Access Journals (Sweden)

    Owunna Ikechukwu

    2016-07-01

    Full Text Available Modal analysis is significant in evaluating the mode shapes generated by a component under vibrational excitation, as the mode shapes can be used to determine the displacement or response of the component under the influence vibration in real life application. Result obtained from the modal analysis will generate a number of resonances which the frequency and damping effect can be determined by measurement. However, determining the accuracy of modal analysis result is somewhat difficult as the experimental results and the results generated by Finite Element Analysis (FEA solvers can be affected by a number of factors pointed out in this paper. In this study, a flat plate was mounted on an electromagnetic shaker which enabled the excitation of the plate, while results of the response were measured using a transducer attached to the plate. The plate was also modelled using CATIA software and the files transferred to the different FEA solvers such as HYPERMESH, ANSYS 6 Degree of Freedom (DOF as well as ANSYS 5 degree of freedom, in which the same analysis was carried out to obtain a set of results other than the experimental results. Each FEA solver generated results that were in close proximity with the experimental results, particularly the results generated by ANSYS 5 Degree of freedom. Hence, to ascertain the accuracy of the results obtained from modal analysis experimental procedure, it is important to match up the results generated from different FEA solvers with the experimental results.

  13. Applications of Digital Image Analysis in Experimental Mechanics

    DEFF Research Database (Denmark)

    Lyngbye, J. : Ph.D.

    The present thesis "Application of Digital Image Analysis in Experimental Mechanics" has been prepared as a part of Janus Lyngbyes Ph.D. study during the period December 1988 to June 1992 at the Department of Building technology and Structural Engineering, University of Aalborg, Denmark....... In this thesis attention will be focused on optimal use and analysis of the information of digital images. This is realized during investigation and application of parametric methods in digital image analysis. The parametric methods will be implemented in applications representative for the area of experimental...

  14. Rings and sector : intrasite spatial analysis of stone age sites.

    NARCIS (Netherlands)

    Stapert, Durk

    1992-01-01

    This thesis deals with intrasite spatial analysis: the analysis of spatial patterns on site level. My main concern has been to develop a simple method for analysing Stone Age sites of a special type: those characterised by the presence of a hearth closely associated in space with an artefact scatter

  15. Spinal alignment evolution with age: A prospective gait analysis study

    Science.gov (United States)

    Pesenti, Sébastien; Blondel, Benjamin; Peltier, Emilie; Viehweger, Elke; Pomero, Vincent; Authier, Guillaume; Fuentes, Stéphane; Jouve, Jean-Luc

    2017-01-01

    AIM To describe, using gait analysis, the development of spinal motion in the growing child. METHODS Thirty-six healthy children aged from 3 to 16 years old were included in this study for a gait analysis (9 m-walk). Various kinematic parameters were recorded and analyzed such as thoracic angle (TA), lumbar angle (LA) and sagittal vertical axis (SVA). The kinetic parameters were the net reaction moments (N.m/kg) at the thoracolumbar and lumbosacral junctions. RESULTS TA and LA curves were not statistically correlated to the age (respectively, P = 0.32 and P = 0.41). SVA increased significantly with age (P < 0.001). Moments in sagittal plane at the lumbosacral junction were statistically correlated to the age (P = 0.003), underlining the fact that sagittal mechanical constraints at the lumbosacral junction increase with age. Moments in transversal plane at the thoracolumbar and lumbosacral junctions were statistically correlated to the age (P = 0.0002 and P = 0.0006), revealing that transversal mechanical constraints decrease with age. CONCLUSION The kinetic analysis showed that during growth, a decrease of torsional constraint occurs while an increase of sagittal constraint is observed. These changes in spine biomechanics are related to the crucial role of the trunk for bipedalism acquisition, allowing stabilization despite lower limbs immaturity. With the acquisition of mature gait, the spine will mainly undergo constraints in the sagittal plane.

  16. Transparent meta-analysis of prospective memory and aging.

    Directory of Open Access Journals (Sweden)

    Bob Uttl

    Full Text Available Prospective memory (ProM refers to our ability to become aware of a previously formed plan at the right time and place. After two decades of research on prospective memory and aging, narrative reviews and summaries have arrived at widely different conclusions. One view is that prospective memory shows large age declines, larger than age declines on retrospective memory (RetM. Another view is that prospective memory is an exception to age declines and remains invariant across the adult lifespan. The present meta-analysis of over twenty years of research settles this controversy. It shows that prospective memory declines with aging and that the magnitude of age decline varies by prospective memory subdomain (vigilance, prospective memory proper, habitual prospective memory as well as test setting (laboratory, natural. Moreover, this meta-analysis demonstrates that previous claims of no age declines in prospective memory are artifacts of methodological and conceptual issues afflicting prior research including widespread ceiling effects, low statistical power, age confounds, and failure to distinguish between various subdomains of prospective memory (e.g., vigilance and prospective memory proper.

  17. Evaluation of Experimental Parameters in the Accelerated Aging of Closed-Cell Foam Insulation

    Energy Technology Data Exchange (ETDEWEB)

    Stovall, Therese K [ORNL; Vanderlan, Michael [ORNL; Atchley, Jerald Allen [ORNL

    2012-12-01

    The thermal conductivity of many closed-cell foam insulation products changes over time as production gases diffuse out of the cell matrix and atmospheric gases diffuse into the cells. Thin slicing has been shown to be an effective means of accelerating this process in such a way as to produce meaningful results. Efforts to produce a more prescriptive version of the ASTM C1303 standard test method led to the ruggedness test described here. This test program included the aging of full size insulation specimens for time periods of five years for direct comparison to the predicted results. Experimental parameters under investigation include: slice thickness, slice origin (at the surface or from the core of the slab), thin slice stack composition, product facings, original product thickness, product density, and product type. The test protocol has been completed and this report provides a detailed evaluation of the impact of the test parameters on the accuracy of the 5-year thermal conductivity prediction.

  18. Ageing and recurrent episodes of neuroinflammation promote progressive experimental autoimmune encephalomyelitis in Biozzi ABH mice.

    Science.gov (United States)

    Peferoen, Laura A N; Breur, Marjolein; van de Berg, Sarah; Peferoen-Baert, Regina; Boddeke, Erik H W G M; van der Valk, Paul; Pryce, Gareth; van Noort, Johannes M; Baker, David; Amor, Sandra

    2016-10-01

    Current therapies for multiple sclerosis (MS) reduce the frequency of relapses by modulating adaptive immune responses but fail to limit the irreversible neurodegeneration driving progressive disability. Experimental autoimmune encephalomyelitis (EAE) in Biozzi ABH mice recapitulates clinical features of MS including relapsing-remitting episodes and secondary-progressive disability. To address the contribution of recurrent inflammatory events and ageing as factors that amplify progressive neurological disease, we examined EAE in 8- to 12-week-old and 12-month-old ABH mice. Compared with the relapsing-remitting (RREAE) and secondary progressive (SPEAE) EAE observed in young mice, old mice developed progressive disease from onset (PEAE) associated with pronounced axonal damage and increased numbers of CD3(+) T cells and microglia/macrophages, but not B cells. Whereas the clinical neurological features of PEAE and SPEAE were comparable, the pathology was distinct. SPEAE was associated with significantly reduced perivascular infiltrates and T-cell numbers in the central nervous system (CNS) compared with PEAE and the acute phase of RREAE. In contrast to perivascular infiltrates that declined during progression from RREAE into SPEAE, the numbers of microglia clusters remained constant. Similar to what is observed during MS, the microglia clusters emerging during EAE were associated with axonal damage and oligodendrocytes expressing heat-shock protein B5, but not lymphocytes. Taken together, our data reveal that the course of EAE is dependent on the age of the mice. Younger mice show a relapsing-remitting phase followed by progressive disease, whereas old mice immediately show progression. This indicates that recurrent episodes of inflammation in the CNS, as well as age, contribute to progressive neurological disease.

  19. Effects of ageing and experimental diabetes on insulin-degrading enzyme expression in male rat tissues.

    Science.gov (United States)

    Kochkina, Ekaterina G; Plesneva, Svetlana A; Vasilev, Dmitrii S; Zhuravin, Igor A; Turner, Anthony J; Nalivaeva, Natalia N

    2015-08-01

    Due to an increasing life expectancy in developing countries, cases of type 2 diabetes and Alzheimer's disease (AD) in the elderly are growing exponentially. Despite a causative link between diabetes and AD, general molecular mechanisms underlying pathogenesis of these disorders are still far from being understood. One of the factors leading to cell death and cognitive impairment characteristic of AD is accumulation in the brain of toxic aggregates of amyloid-β peptide (Aβ). In the normally functioning brain Aβ catabolism is regulated by a cohort of proteolytic enzymes including insulin-degrading enzyme (IDE) and their deficit with ageing can result in Aβ accumulation and increased risk of AD. The aim of this study was a comparative analysis of IDE expression in the brain structures involved in AD, as well as in peripheral organs (the liver and kidney) of rats, during natural ageing and after experimentally-induced diabetes. It was found that ageing is accompanied by a significant decrease of IDE mRNA and protein content in the liver (by 32 and 81%) and brain structures (in the cortex by 58 and 47% and in the striatum by 53 and 68%, respectively). In diabetic animals, IDE protein level was increased in the liver (by 36%) and in the striatum (by 42%) while in the brain cortex and hippocampus it was 20-30% lower than in control animals. No significant IDE protein changes were observed in the kidney of diabetic rats. These data testify that ageing and diabetes are accompanied by a deficit of IDE in the brain structures where accumulation of Aβ was reported in AD patients, which might be one of the factors predisposing to development of the sporadic form of AD in the elderly, and especially in diabetics.

  20. [Aging at home with telecare in Spain. A dicourse analysis].

    Science.gov (United States)

    Aceros, Juan C; Cavalcante, Maria Tereza Leal; Domènech, Miquel

    2016-08-01

    Caring for the elderly is turning to forms of community care and home care. Telecare is one of those emergent modalities of caring. This article will explore the meanings that older people give to the experience of staying at home in later life by using telecare. Discourse analysis is used to examine a set of focus groups and interviews with telecare users from different cities of Catalonia (Spain). The outcomes include three interpretative repertoires that we called: "Aging at home", "normal aging" and "unsafe aging". For each repertoire we examine how the permanence of older people in their homes is accounted, and which role telecare plays in such experience.

  1. The influence of age and genetics on natural resistance to experimentally induced feline infectious peritonitis.

    Science.gov (United States)

    Pedersen, Niels C; Liu, Hongwei; Gandolfi, Barbara; Lyons, Leslie A

    2014-11-15

    Naturally occurring feline infectious peritonitis (FIP) is usually fatal, giving the impression that immunity to the FIP virus (FIPV) is extremely poor. This impression may be incorrect, because not all cats experimentally exposed to FIPV develop FIP. There is also a belief that the incidence of FIP may be affected by a number of host, virus, and environmental cofactors. However, the contribution of these cofactors to immunity and disease incidence has not been determined. The present study followed 111 random-bred specific pathogen free (SPF) cats that were obtained from a single research breeding colony and experimentally infected with FIPV. The cats were from several studies conducted over the past 5 years, and as a result, some of them had prior exposure to feline enteric coronavirus (FECV) or avirulent FIPVs. The cats were housed under optimized conditions of nutrition, husbandry, and quarantine to eliminate most of the cofactors implicated in FIPV infection outcome and were uniformly challenge exposed to the same field strain of serotype 1 FIPV. Forty of the 111 (36%) cats survived their initial challenge exposure to a Type I cat-passaged field strains of FIPV. Six of these 40 survivors succumbed to FIP to a second or third challenge exposure, suggesting that immunity was not always sustained. Exposure to non-FIP-inducing feline coronaviruses prior to challenge with virulent FIPV did not significantly affect FIP incidence but did accelerate the disease course in some cats. There were no significant differences in FIP incidence between males and females, but resistance increased significantly between 6 months and 1 or more years of age. Genetic testing was done on 107 of the 111 infected cats. Multidimensional scaling (MDS) segregated the 107 cats into three distinct families based primarily on a common sire(s), and resistant and susceptible cats were equally distributed within each family. Genome-wide association studies (GWAS) on 73 cats that died of FIP

  2. VIRTUAL EXPERIMENTAL ANALYSIS ON CLEANING ELEMENT OF SUGARCANE HARVESTER

    Institute of Scientific and Technical Information of China (English)

    Ma Fanglan; Li Shangping; He Yulin; Meng Yanmei; Chen Weixu

    2005-01-01

    The laws of influence of different factors have been analyzed in order to enhance the working efficiency and fatigue life of the cleaning element in brush shape of the sugarcane harvester.Based on the principle of orthogonal experiment design, the virtual-orthogonal-experimental analysis for the cleaning element is carried out on the finite element analysis (FEA) software-ANSYS after analyzing the nonlinear structural behavior in the working procedure. The results are analyzed with the overall balancing method, and then the optimal combination is got, which is made up of different levels of different factors. Also the optimal combination of design parameters of the cleaning element received from the virtual experimental analysis is conducted an experiment to confirm that the virtual analysis model and results are right, and the effect of factors on the function of the cleaning element is obtained by more analysis and further optimizing.

  3. Effect of Cistanche Desertica Polysaccharides on Learning and Memory Functions and Ultrastructure of Cerebral Neurons in Experimental Aging Mice

    Institute of Scientific and Technical Information of China (English)

    孙云; 邓杨梅; 王德俊; 沈春锋; 刘晓梅; 张洪泉

    2001-01-01

    To observe the effects of Cistanche desertica polysaccharides (CDP) on the learning and memory functions and cerebral ultrastructure in experimental aging mice. Methods: CDP was administrated intragastrically 50 or 100 mg/kg per day for 64 successive days to experimental aging model mice induced by D-galactose, then the learning and memory functions of mice were estimated by step-down test and Y-maze test; organelles of brain tissue and cerebral ultrastructure were observed by transmission electron microscope and physical strength was determined by swimming test. Results: CDP could obviously enhance the learning and memory functions (P<0.01) and prolong the swimming time (P<0.05), decrease the number of lipofuscin and slow down the degeneration of mitochondria in neurons(P<0.05), and improve the degeneration of cerebral ultra-structure in aging mice. Conclusion: CDP could improve the impaired physiological function and alleviate cerebral morphological change in experimental aging mice.

  4. Growth characteristics and Otolith analysis on Age-0 American Shad

    Science.gov (United States)

    Sauter, Sally T.; Wetzel, Lisa A.

    2011-01-01

    Otolith microstructure analysis provides useful information on the growth history of fish (Campana and Jones 1992, Bang and Gronkjaer 2005). Microstructure analysis can be used to construct the size-at-age growth trajectory of fish, determine daily growth rates, and estimate hatch date and other ecologically important life history events (Campana and Jones 1992, Tonkin et al. 2008). This kind of information can be incorporated into bioenergetics modeling, providing necessary data for estimating prey consumption, and guiding the development of empirically-based modeling scenarios for hypothesis testing. For example, age-0 American shad co-occur with emigrating juvenile fall Chinook salmon originating from Hanford Reach and the Snake River in the lower Columbia River reservoirs during the summer and early fall. The diet of age-0 American shad appears to overlap with that of juvenile fall Chinook salmon (Chapter 1, this report), but juvenile fall Chinook salmon are also known to feed on age-0 American shad in the reservoirs (USGS unpublished data). Abundant, energy-dense age-0 American shad may provide juvenile fall Chinook salmon opportunities for rapid growth during the time period when large numbers of age-0 American shad are available. Otolith analysis of hatch dates and the growth curve of age-0 American shad could be used to identify when eggs, larvae, and juveniles of specific size classes are temporally available as food for fall Chinook salmon in the lower Columbia River reservoirs. This kind of temporally and spatially explicit life history information is important to include in bioenergetics modeling scenarios. Quantitative estimates of prey consumption could be used with spatially-explicit estimates of prey abundance to construct a quantitative assessment of the age-0 American shad impact on a reservoir food web.

  5. Documenting Differences between Early Stone Age Flake Production Systems: An Experimental Model and Archaeological Verification.

    Science.gov (United States)

    Presnyakova, Darya; Archer, Will; Braun, David R; Flear, Wesley

    2015-01-01

    This study investigates morphological differences between flakes produced via "core and flake" technologies and those resulting from bifacial shaping strategies. We investigate systematic variation between two technological groups of flakes using experimentally produced assemblages, and then apply the experimental model to the Cutting 10 Mid -Pleistocene archaeological collection from Elandsfontein, South Africa. We argue that a specific set of independent variables--and their interactions--including external platform angle, platform depth, measures of thickness variance and flake curvature should distinguish between these two technological groups. The role of these variables in technological group separation was further investigated using the Generalized Linear Model as well as Linear Discriminant Analysis. The Discriminant model was used to classify archaeological flakes from the Cutting 10 locality in terms of their probability of association, within either experimentally developed technological group. The results indicate that the selected independent variables play a central role in separating core and flake from bifacial technologies. Thickness evenness and curvature had the greatest effect sizes in both the Generalized Linear and Discriminant models. Interestingly the interaction between thickness evenness and platform depth was significant and played an important role in influencing technological group membership. The identified interaction emphasizes the complexity in attempting to distinguish flake production strategies based on flake morphological attributes. The results of the discriminant function analysis demonstrate that the majority of flakes at the Cutting 10 locality were not associated with the production of the numerous Large Cutting Tools found at the site, which corresponds with previous suggestions regarding technological behaviors reflected in this assemblage.

  6. Analysis of adult patients with epilepsy in the age continuum

    Directory of Open Access Journals (Sweden)

    V. A. Karlov

    2016-01-01

    Full Text Available Objective: to study the presence of comorbidities and to investigate quality of life in patients with main types of epilepsy in relation to age.Patients and methods. The investigation enrolled 150 patients aged 17 to 64 years with idiopathic, cryptogenic, and symptomatic types of epilepsy. The investigators studied the presence of sleep disorders using the questionnaires designed by the Somnology Center, Ministry of Health of Russia, and that of daytime sleepiness by the Epworth Sleepiness Scale, determined the level of anxiety and depression by the Hospital Anxiety and Depression Scale, and assessed the severity of seizures by the National Hospital Seizure Severity Scale. Quality of life was investigated using the QOLIE-89 questionnaire. A cluster analysis was carried out to divide all the patients into three age groups (mean age, 27.3; 30.7; and 37.7 years.Results and discussion. A positive relationship was obtained between some indicators of sleep disorders, level of anxiety, and age. There were significant differences between the above three age groups in the following indicators: sleep disorders; daytime sleepiness; level of anxiety, severity of seizures, and scores of the QOLIE-89 questionnaire (p<0.001. Since the patients suffer from different basic types of epilepsy (cryptogenic, idiopathic, and symptomatic, the findings testify to age as an independent factor that modifies quality of life in epileptic patients.

  7. Demographic analysis from summaries of an age-structured population

    Science.gov (United States)

    Link, William A.; Royle, J. Andrew; Hatfield, Jeff S.

    2003-01-01

    Demographic analyses of age-structured populations typically rely on life history data for individuals, or when individual animals are not identified, on information about the numbers of individuals in each age class through time. While it is usually difficult to determine the age class of a randomly encountered individual, it is often the case that the individual can be readily and reliably assigned to one of a set of age classes. For example, it is often possible to distinguish first-year from older birds. In such cases, the population age structure can be regarded as a latent variable governed by a process prior, and the data as summaries of this latent structure. In this article, we consider the problem of uncovering the latent structure and estimating process parameters from summaries of age class information. We present a demographic analysis for the critically endangered migratory population of whooping cranes (Grus americana), based only on counts of first-year birds and of older birds. We estimate age and year-specific survival rates. We address the controversial issue of whether management action on the breeding grounds has influenced recruitment, relating recruitment rates to the number of seventh-year and older birds, and examining the pattern of variation through time in this rate.

  8. Kinematic Analysis and Experimental Verification on the Locomotion of Gecko

    Institute of Scientific and Technical Information of China (English)

    Woochul Nam; TaeWon Seo; Byungwook Kim; Dongsu Jeon; Kyu-Jin Cho; Jongwon Kim

    2009-01-01

    This paper presents a kinematic analysis of the locomotion of a gecko, and experimental verification of the kinematic model. Kinematic analysis is important for parameter design, dynamic analysis, and optimization in biomimetic robot research. The proposed kinematic analysis can simulate, without iteration, the locomotion of gecko satisfying the constraint conditions that maintain the position of the contacted feet on the surface. So the method has an advantage for analyzing the climbing motion of the quadruped mechanism in a real time application. The kinematic model of a gecko consists of four legs based on 7-degrees of freedom spherical-revolute-spherical joints and two revolute joints in the waist. The motion of the kinematic model is simulated based on measurement data of each joint. The motion of the kinematic model simulates the investigated real gecko's motion by using the experimental results. The analysis solves the forward kinematics by considering the model as a combination of closed and open serial mechanisms under the condition that maintains the contact positions of the attached feet on the ground. The motions of each joint are validated by comparing with the experimental results. In addition to the measured gait, three other gaits are simulated based on the kinematic model. The maximum strides of each gait are calculated by workspace analysis. The result can be used in biomimetic robot design and motion planning.

  9. Experimental bifurcation analysis of an impact oscillator – Determining stability

    DEFF Research Database (Denmark)

    Bureau, Emil; Schilder, Frank; Elmegård, Michael

    2014-01-01

    We propose and investigate three different methods for assessing stability of dynamical equilibrium states during experimental bifurcation analysis, using a control-based continuation method. The idea is to modify or turn off the control at an equilibrium state and study the resulting behavior. A...

  10. Procesamiento de oraciones ambiguas de "vía muerta" y envejecimiento: un estudio experimental ("Garden path" sentences processing and aging: An experimental study

    Directory of Open Access Journals (Sweden)

    Katia Sáez

    2011-12-01

    Full Text Available Se presentan los resultados de un estudio experimental cuyo propósito es determinar si el envejecimiento cognitivo normal afecta o no el procesamiento de oraciones ambiguas de "vía muerta" que llevan a cabo los adultos mayores. La hipótesis que se somete a prueba empírica es que la reducción de la capacidad de la memoria operativa, debido al envejecimiento cognitivo normal, produce como efecto un declive en la capacidad de procesamiento sintáctico de estructuras sintácticas ambiguas, lo que eventualmente podría afectar a la comprensión de la oración. En el experimento se compara el desempeño de 39 adultos jóvenes y 31 adultos mayores en una tarea de lectura cronometrada de oraciones que presentan ambigüedad sintáctica temporal del tipo objeto directo/sujeto ("Mientras la joven montaba el potro fue robado de las caballerizas", seguida de una tarea de comprensión. El análisis de las diferencias encontradas en los tiempos de lectura y comprensión de las oraciones no corroboran sino en forma parcial la hipótesis. (This article presents the results of an experimental study whose purpose is to determine whether normal cognitive aging affects older adult’s processing of ambiguous "garden path" sentences. The hypothesis that is tested empirically postulates that the reduction in the capacity of working memory due to normal cognitive aging produces a decline in the ambiguous garden path syntactic structure processing, which would eventually affect sentence comprehension. The experiment compares the performance of 39 young adults and 31 older adults in a timed reading comprehension task of sentences that contain direct object /subject temporary syntactic ambiguity ("Mientras la joven montaba el potro fue robado de las caballerizas", 'While the girl was riding the horse was stolen from the stables'. Each sentence was followed by a comprehension task. The analysis of the differences in reading times and sentence comprehension partially

  11. Genes, age, and alcoholism: analysis of GAW14 data.

    Science.gov (United States)

    Apprey, Victor; Afful, Joseph; Harrell, Jules P; Taylor, Robert E; Bonney, George E

    2005-12-30

    A genetic analysis of age of onset of alcoholism was performed on the Collaborative Study on the Genetics of Alcoholism data released for Genetic Analysis Workshop 14. Our study illustrates an application of the log-normal age of onset model in our software Genetic Epidemiology Models (GEMs). The phenotype ALDX1 of alcoholism was studied. The analysis strategy was to first find the markers of the Affymetrix SNP dataset with significant association with age of onset, and then to perform linkage analysis on them. ALDX1 revealed strong evidence of linkage for marker tsc0041591 on chromosome 2 and suggestive linkage for marker tsc0894042 on chromosome 3. The largest separation in mean ages of onset of ALDX1 was 19.76 and 24.41 between male smokers who are carriers of the risk allele of tsc0041591 and the non-carriers, respectively. Hence, male smokers who are carriers of marker tsc0041591 on chromosome 2 have an average onset of ALDX1 almost 5 years earlier than non-carriers.

  12. SAFETY ANALYSIS METHODOLOGY FOR AGED CANDU® 6 NUCLEAR REACTORS

    Directory of Open Access Journals (Sweden)

    WOLFGANG HARTMANN

    2013-10-01

    Full Text Available This paper deals with the Safety Analysis for CANDU® 6 nuclear reactors as affected by main Heat Transport System (HTS aging. Operational and aging related changes of the HTS throughout its lifetime may lead to restrictions in certain safety system settings and hence some restriction in performance under certain conditions. A step in confirming safe reactor operation is the tracking of relevant data and their corresponding interpretation by the use of appropriate thermalhydraulic analytic models. Safety analyses ranging from the assessment of safety limits associated with the prevention of intermittent fuel sheath dryout for a slow Loss of Regulation (LOR analysis and fission gas release after a fuel failure are summarized. Specifically for fission gas release, the thermalhydraulic analysis for a fresh core and an 11 Effective Full Power Years (EFPY aged core was summarized, leading to the most severe stagnation break sizes for the inlet feeder break and the channel failure time. Associated coolant conditions provide the input data for fuel analyses. Based on the thermalhydraulic data, the fission product inventory under normal operating conditions may be calculated for both fresh and aged cores, and the fission gas release may be evaluated during the transient. This analysis plays a major role in determining possible radiation doses to the public after postulated accidents have occurred.

  13. Elevation of cartilage AGEs does not accelerate initiation of canine experimental osteoarthritis upon mild surgical damage

    NARCIS (Netherlands)

    Vos, P.A.J.M.; Degroot, J.; Barten-Van Rijbroek, A.D.; Zuurmond, A.-M.; Bijlsma, J.W.J.; Mastbergen, S.C.; Lafeber, F.P.J.G.

    2012-01-01

    Osteoarthritis is a highly prevalent disease, age being the main risk factor. The age-related accumulation of advanced-glycation-endproducts (AGEs) adversely affects the mechanical and biochemical properties of cartilage. The hypothesis that accumulation of cartilage AGEs in combination with surgica

  14. An Experimental Metagenome Data Management and AnalysisSystem

    Energy Technology Data Exchange (ETDEWEB)

    Markowitz, Victor M.; Korzeniewski, Frank; Palaniappan, Krishna; Szeto, Ernest; Ivanova, Natalia N.; Kyrpides, Nikos C.; Hugenholtz, Philip

    2006-03-01

    The application of shotgun sequencing to environmental samples has revealed a new universe of microbial community genomes (metagenomes) involving previously uncultured organisms. Metagenome analysis, which is expected to provide a comprehensive picture of the gene functions and metabolic capacity of microbial community, needs to be conducted in the context of a comprehensive data management and analysis system. We present in this paper IMG/M, an experimental metagenome data management and analysis system that is based on the Integrated Microbial Genomes (IMG) system. IMG/M provides tools and viewers for analyzing both metagenomes and isolate genomes individually or in a comparative context.

  15. Aging Analysis of Micromegas Detectors for ATLAS New Small Wheel

    CERN Document Server

    Quinnan, Melissa

    2015-01-01

    In preparation for the coming High Luminosity Large Hadron Collider (HL-LHC) upgrade, the New Small Wheel (NSW) will replace the Small Wheel of the ATLAS Muon Spectrometer as part of the 2018 ATLAS Phase-I upgrade. Micromegas (MM) detectors will serve as one component of the NSW. These gaseous micro-mesh detectors will accommodate the higher luminosity and trigger rate of the future HL-LHC.In order to predict performance of MM after several years in the HL-LHC, radiation aging tests were conducted in the Gamma Irradiation Facility (GIF++) using a Cs 137 source. Two small MM prototype "T" chambers were irradiated and studied over the course of several months to accelerate the aging process and characterize chamber behavior. This report outlines a record of the aging process thus far and demonstrates techniques used to describe aging effects, namely measurements of average current, integrated charge, and gain. These will be used in the ongoing aging analysis of the T chambers and in future aging studies of the ...

  16. Analytical and experimental analysis of tube coil heat exchanger

    Science.gov (United States)

    Smusz, R.

    2016-09-01

    The paper presents the analytical and experimental analysis of heat transfer for the finned tube coil heat exchanger immersed in thermal storage tank. The tank is equipped with three helical-shaped heating coils and cylindrical- shaped stratification device. Two coils, upper and lower, use the water as a heating medium. The third, double wall heat exchanger coil, located at the bottom head on the tank is filled by the refrigerant (freon). Calculations of thermal power of water coil were made. Correlations of heat transfer coefficients in curved tubes were applied. In order to verify the analytical calculations the experimental studies of heat transfer characteristic for coil heat exchanger were performed.

  17. Experimental design and analysis for accelerated degradation tests with Li-ion cells.

    Energy Technology Data Exchange (ETDEWEB)

    Doughty, Daniel Harvey; Thomas, Edward Victor; Jungst, Rudolph George; Roth, Emanuel Peter

    2003-08-01

    This document describes a general protocol (involving both experimental and data analytic aspects) that is designed to be a roadmap for rapidly obtaining a useful assessment of the average lifetime (at some specified use conditions) that might be expected from cells of a particular design. The proposed experimental protocol involves a series of accelerated degradation experiments. Through the acquisition of degradation data over time specified by the experimental protocol, an unambiguous assessment of the effects of accelerating factors (e.g., temperature and state of charge) on various measures of the health of a cell (e.g., power fade and capacity fade) will result. In order to assess cell lifetime, it is necessary to develop a model that accurately predicts degradation over a range of the experimental factors. In general, it is difficult to specify an appropriate model form without some preliminary analysis of the data. Nevertheless, assuming that the aging phenomenon relates to a chemical reaction with simple first-order rate kinetics, a data analysis protocol is also provided to construct a useful model that relates performance degradation to the levels of the accelerating factors. This model can then be used to make an accurate assessment of the average cell lifetime. The proposed experimental and data analysis protocols are illustrated with a case study involving the effects of accelerated aging on the power output from Gen-2 cells. For this case study, inadequacies of the simple first-order kinetics model were observed. However, a more complex model allowing for the effects of two concurrent mechanisms provided an accurate representation of the experimental data.

  18. Experimental evidence against the mitochondrial theory of aging - A study of isolated human skeletal muscle mitochondria

    DEFF Research Database (Denmark)

    Rasmussen, Ulla Fugmann; Krustrup, Peter; Kjær, Michael;

    2003-01-01

    age effects, ATP formation, BSA effects, collagen content, low temperature spectroscopy, oxygen uptakes, quadriceps muscle, respiration, specific enzyme activities......age effects, ATP formation, BSA effects, collagen content, low temperature spectroscopy, oxygen uptakes, quadriceps muscle, respiration, specific enzyme activities...

  19. Renoprotective effects of the AGE-inhibitor pyridoxamine in experimental chronic allograft nephropathy in rats

    NARCIS (Netherlands)

    Waanders, Femke; van den Berg, Else; Nagai, Ryoji; van Veen, Ingrid; Navis, Gerjan; van Goor, Harry

    2008-01-01

    Background. Advanced glycation end products (AGEs) are involved in diabetic nephropathy (DN). The AGE formation inhibitor pyridoxamine (PM) is renoprotective in DN and in normoglycaemic obese Zucker rats. In chronic allograft nephropathy (CAN), renal AGE accumulation occurs as well. Methods. To inve

  20. Torsional Oscillations in Automotive Transmissions: Experimental Analysis and Modelling

    Directory of Open Access Journals (Sweden)

    Enrico Galvagno

    2016-01-01

    Full Text Available The paper investigates the torsional oscillations of an automotive transmission system by means of an experimental test bench used to validate the proposed lumped parameter model. The rig consists of a Dual Clutch Transmission (DCT and a Manual Transmission (MT connected through the respective output shafts, while the excitation is provided by two electric motors, which are controlled in speed or torque. The experimental analysis includes the measurement of the external torques, applied by the two electric motors to the mechanical system, and the measurement of the system response in terms of angular speeds at different positions along the transmission line. The frequency response of the system is estimated from the experimental data and compared with the results of a 5-degree-of-freedom lumped parameter model, which proves to be adequate to describe the dynamic behaviour of the system up to a frequency of 200 Hz. The comparison between simulated results and experimental data shows good agreement, so the model can be used to predict the torsional vibrations of the transmission system in the linear field. Moreover, the effects of the nonlinearities associated with the mean value of the excitations are shown. Finally the influence of the selected gear ratio on the experimental frequency response is discussed.

  1. SiSn diodes: Theoretical analysis and experimental verification

    KAUST Repository

    Hussain, Aftab M.

    2015-08-24

    We report a theoretical analysis and experimental verification of change in band gap of silicon lattice due to the incorporation of tin (Sn). We formed SiSn ultra-thin film on the top surface of a 4 in. silicon wafer using thermal diffusion of Sn. We report a reduction of 0.1 V in the average built-in potential, and a reduction of 0.2 V in the average reverse bias breakdown voltage, as measured across the substrate. These reductions indicate that the band gap of the silicon lattice has been reduced due to the incorporation of Sn, as expected from the theoretical analysis. We report the experimentally calculated band gap of SiSn to be 1.11 ± 0.09 eV. This low-cost, CMOS compatible, and scalable process offers a unique opportunity to tune the band gap of silicon for specific applications.

  2. Analysis of surface hardness of artificially aged resin composites

    Directory of Open Access Journals (Sweden)

    Denise Cremonezzi Tornavoi

    2012-02-01

    Full Text Available This study evaluated the effect of artificially accelerated aging (AAA on the surface hardness of eight composite resins: Filtek Z250, Filtek Supreme, 4 Seasons, Herculite, P60, Tetric Ceram, Charisma, and Filtek Z100. Sixteen specimens were made from the test piece of each material, using an 8.0 × 2.0 mm teflon matrix. After 24 hours, eight specimens from each material were submitted to three surface hardness readings using a Shimadzu Microhardness Tester for 5 seconds at a load of 50 gf. The other eight specimens remained in the artificially accelerated aging machine for 382 hours and were submitted to the same surface hardness analysis. The means of each test specimen were submitted to the Kolmogorov-Smirnov test (p > 0.05, ANOVA and Tukey test (p < 0.05. With regard to hardness (F = 86.74, p < 0.0001 the analysis showed significant differences among the resin composite brands. But aging did not influence the hardness of any of the resin composites (F = 0.39, p = 0.53. In this study, there was interaction between the resin composite brand and the aging factors (F = 4.51, p < 0.0002. It was concluded that notwithstanding the type of resin, AAA did not influence surface hardness. However, with regard to hardness there was a significant difference among the resin brands.

  3. Age-related differences in experimental stroke: possible involvement of mitochondrial dysfunction and oxidative damage.

    Science.gov (United States)

    Li, Nanlin; Kong, Xiangwei; Ye, Ruidong; Yang, Qianzi; Han, Junliang; Xiong, Lize

    2011-06-01

    Age is the single most important risk factor for cerebral stroke. Unfortunately, the effect of age on ischemic brain damage is less clear. In this study, we sought to examine the potential influence of aging on the histologic and functional outcomes after ischemia. Juvenile (4 weeks of age), young adult (4 months of age), mid-aged (11-12 months of age), and aged (18-19 months of age) mice were subjected to transient middle cerebral artery occlusion. There was no remarkable difference of infarct volume on postoperative days 1 and 3. However, on postoperative day 7, aged mice exhibited significantly worsened infarct volume compared with juvenile and young mice. Intriguingly, the increase of infarct volume was most prominent in the striatal area rather than in cortex. Accordingly, aged mice displayed a slower and incomplete functional recovery after stroke. We further evaluated the effects of aging on the oxidative damage and mitochondrial dysfunction following ischemia. Brain tissues were assayed for lipid, DNA, and protein peroxidation products, mitochondrial enzyme activities, mitochondrial membrane potential, production of reactive oxygen species, and antioxidant activities. Aging was associated with declined mitochondrial function and antioxidant detoxification following ischemia, thereby inducing a deteriorated oxidative damage. Regional subanalyses demonstrated that, in accordance with infarct area, the pro-oxidant/antioxidant imbalance occurred more prominently in subcortical areas. Collectively, these findings suggest mitochondria-mediated oxidative damage may be involved in the age-related aggravated injury in subcortical areas. Mitochondrial protection could be a promising target for neuroprotective therapy, especially in the aged population.

  4. Cognition, behavior, and the experimental analysis of behavior

    OpenAIRE

    Shimp, Charles P.

    1984-01-01

    A case history illustrates how one research program in the experimental analysis of behavior evolved somewhat differently from the modal research program represented in this journal. A chief issue that seems to be responsible for this difference is the role attributed to theory in behavioral research: Skinner's views on the nature and function of theory and on the nature of observation combine to produce a certain kind of picture of behavior. The classic conception of reinforcement contingenc...

  5. New experimental and analysis methods in I-DLTS

    Energy Technology Data Exchange (ETDEWEB)

    Pandey, S.U.; Middelkamp, P.; Li, Z.; Eremin, V.

    1998-02-01

    A new experimental apparatus to perform I-DLTS measurements is presented. The method is shown to be faster and more sensitive than traditional double boxcar I-DLTS systems. A novel analysis technique utilizing multiple exponential fits to the I-DLTS signal from a highly neutron irradiated silicon sample is presented with a discussion of the results. It is shown that the new method has better resolution and can deconvolute overlapping peaks more accurately than previous methods.

  6. New experimental and analysis methods in I-DLTS

    Energy Technology Data Exchange (ETDEWEB)

    Pandey, S.U. E-mail: sanjeev@bnl.gov; Middelkamp, P.; Li, Z.; Eremin, V

    1999-04-21

    A simple modification to traditional experimental apparatus to perform I-DLTS measurements is presented. This setup is shown to be faster and more sensitive than traditional double boxcar I-DLTS systems. A novel analysis technique utilising multiple exponential fits to the I-DLTS signal from a highly neutron irradiated silicon sample is presented along with a discussion of the results. It is shown that the new method has better resolution and can deconvolute overlapping peaks more accurately than previous methods.

  7. Synergistic effect of estradiol and fluoxetine in young adult and middle-aged female rats in two models of experimental depression.

    Science.gov (United States)

    Récamier-Carballo, Soledad; Estrada-Camarena, Erika; Reyes, Rebeca; Fernández-Guasti, Alonso

    2012-08-01

    The antidepressant effect of estrogens combined with antidepressants is controversial: some preclinical data showed that estrogens facilitate the effect of antidepressants in the forced swimming test (FST) in young adult rats, while others failed to find such effect in middle-aged rats in the chronic mild stress (CMS) model. In clinics similar differences were reported and may be due to the compounds, the depression model or type of depression, the experimental design, and the age of the subjects or the women's menopause stage. The objective of this study was to analyze the antidepressant-like effect of the combination of 17β-estradiol (E(2)) and fluoxetine (FLX) in young adults (2-4 months) and middle-aged (12-14 months) ovariectomized (OVX) rats in two experimental models: FST and CMS. E(2) (5 and 10 μg/rat) and FLX (2.5 and 10 mg/kg) per se dose-dependently reduced immobility in both age groups and, in young adults both compounds increased swimming, whereas in middle-aged rats they increased swimming and climbing. Analysis of the antidepressant-like effect of the combination of suboptimal doses of FLX (1.25 mg/kg) and E(2) (2.5 μg/rat) showed a decrease in immobility and an increase in swimming in both age groups. In the CMS, chronic E(2) (2.5 μg/rat) with FLX (1.25 mg/kg) augmented relative sucrose intake, but middle-aged rats responded 2 weeks earlier than young adults. These results show that the antidepressant-like effect of the combination of E(2) and FLX in young adult and middle-aged female rats is evidenced in the two animal models of depression: FST and CMS.

  8. The attitudes to ageing questionnaire: Mokken scaling analysis.

    Directory of Open Access Journals (Sweden)

    Susan D Shenkin

    Full Text Available BACKGROUND: Hierarchical scales are useful in understanding the structure of underlying latent traits in many questionnaires. The Attitudes to Ageing Questionnaire (AAQ explored the attitudes to ageing of older people themselves, and originally described three distinct subscales: (1 Psychosocial Loss (2 Physical Change and (3 Psychological Growth. This study aimed to use Mokken analysis, a method of Item Response Theory, to test for hierarchies within the AAQ and to explore how these relate to underlying latent traits. METHODS: Participants in a longitudinal cohort study, the Lothian Birth Cohort 1936, completed a cross-sectional postal survey. Data from 802 participants were analysed using Mokken Scaling analysis. These results were compared with factor analysis using exploratory structural equation modelling. RESULTS: Participants were 51.6% male, mean age 74.0 years (SD 0.28. Three scales were identified from 18 of the 24 items: two weak Mokken scales and one moderate Mokken scale. (1 'Vitality' contained a combination of items from all three previously determined factors of the AAQ, with a hierarchy from physical to psychosocial; (2 'Legacy' contained items exclusively from the Psychological Growth scale, with a hierarchy from individual contributions to passing things on; (3 'Exclusion' contained items from the Psychosocial Loss scale, with a hierarchy from general to specific instances. All of the scales were reliable and statistically significant with 'Legacy' showing invariant item ordering. The scales correlate as expected with personality, anxiety and depression. Exploratory SEM mostly confirmed the original factor structure. CONCLUSIONS: The concurrent use of factor analysis and Mokken scaling provides additional information about the AAQ. The previously-described factor structure is mostly confirmed. Mokken scaling identifies a new factor relating to vitality, and a hierarchy of responses within three separate scales, referring to

  9. Analysis of May Welland in The Age of Innocence

    Institute of Scientific and Technical Information of China (English)

    李鹏

    2013-01-01

    Although many critics hold the opinion that May Welland in the novel of The Age of Innocence is something hypocritical and the murder of killing the love between Newland and Ellen, it is she who defended Newland, his reputation and their family. Through the analysis of May from some special aspects, this paper holds the opinion that May was a stronger full of sense of modern and had the power to live in a difficult condition with limited advantages.

  10. Validation of Comprehensive Helicopter Aeroelastic Analysis with Experimental Data

    Directory of Open Access Journals (Sweden)

    Shrinivas R. Bhat

    2004-10-01

    Full Text Available The experimental data for a Cbladed soft-inplane hingeless main rotor is used to validate a comprehensive aeroelastic analysis. A finite element model has been developed for the rotorblade which predicts rotating frequencies quite well, across a range of rotation speeds. The helicopter is trimmed and the predicted trim-control angles are found to be In the range ofmeasured values for a variety of flight speeds. Power predictions over a range of forward speeds also compare well. Finally, the aeroelastlc analysis is used to study the Importance ofaerodynamic models on the vibration predict~onU. nsteady aerodynamics and free-wake models have been investigated.

  11. Paleodemographic age-at-death distributions of two Mexican skeletal collections: a comparison of transition analysis and traditional aging methods.

    Science.gov (United States)

    Bullock, Meggan; Márquez, Lourdes; Hernández, Patricia; Ruíz, Fernando

    2013-09-01

    Traditional methods of aging adult skeletons suffer from the problem of age mimicry of the reference collection, as described by Bocquet-Appel and Masset (1982). Transition analysis (Boldsen et al., 2002) is a method of aging adult skeletons that addresses the problem of age mimicry of the reference collection by allowing users to select an appropriate prior probability. In order to evaluate whether transition analysis results in significantly different age estimates for adults, the method was applied to skeletal collections from Postclassic Cholula and Contact-Period Xochimilco. The resulting age-at-death distributions were then compared with age-at-death distributions for the two populations constructed using traditional aging methods. Although the traditional aging methods result in age-at-death distributions with high young adult mortality and few individuals living past the age of 50, the age-at-death distributions constructed using transition analysis indicate that most individuals who lived into adulthood lived past the age of 50.

  12. Growth characteristics and otolith analysis on age-0 American shad

    Science.gov (United States)

    Sauter, Sally T.; Wetzel, Lisa A.

    2011-01-01

    Otolith microstructure analysis provides useful information on the growth history of fish (Campana and Jones 1992, Bang and Gronkjaer 2005). Microstructure analysis can be used to construct the size-at-age growth trajectory of fish, determine daily growth rates, and estimate hatch date and other ecologically important life history events (Campana and Jones 1992, Tonkin et al. 2008). This kind of information can be incorporated into bioenergetics modeling, providing necessary data for estimating prey consumption, and guiding the development of empirically-based modeling scenarios for hypothesis testing. For example, age-0 American shad co-occur with emigrating juvenile fall Chinook salmon originating from Hanford Reach and the Snake River in the lower Columbia River reservoirs during the summer and early fall. The diet of age-0 American shad appears to overlap with that of juvenile fall Chinook salmon (Chapter 1, this reoprt), but juvenile fall Chinook salmon are also known to feed on age-0 American shad in the reservoirs (USGS unpublished data). Abundant, energy-dense age-0 American shad may provide juvenile fall Chinook salmon opportunities for rapid growth during the time period when large number of age-0 American shad are available. Otolith analysis of hatch dates and the growth curve of age-0 American shad could be used to identify when eggs, larvae, and juveniles of specific size classes are temporally available as food for fall Chinook salmon in the lower Columbia River reservoirs. This kind of temporally and spatially explicit life history information is important to include in bioenergetics modeling scenarios. Quantitive estimates of prey consumption could be used with spatially-explicit estimates of prey abundance to construct a quantitative assessment of the age-0 American shad impact on a reservoir food web. Analysis of the age-0 American shad growth trajectory or individual growth records may show evidence of differential growth rates over time that may

  13. Software Aging Analysis of Web Server Using Neural Networks

    Directory of Open Access Journals (Sweden)

    G.Sumathi

    2012-05-01

    Full Text Available Software aging is a phenomenon that refers to progressive performance degradation or transient failures or even crashes in long running software systems such as web servers. It mainly occurs due to the deterioration of operating system resource, fragmentation and numerical error accumulation. A primitive method to fight against software aging is software rejuvenation. Software rejuvenation is a proactive fault management technique aimed at cleaning up the system internal state to prevent the occurrence of more severe crash failures in the future. It involves occasionally stopping the running software, cleaning its internal state and restarting it. An optimized schedule for performing the software rejuvenation has to be derived in advance because a long running application could not be put down now and then as it may lead to waste of cost. This paper proposes a method to derive an accurate and optimized schedule for rejuvenation of a web server (Apache by using Radial Basis Function (RBF based Feed Forward Neural Network, a variant of Artificial Neural Networks (ANN. Aging indicators are obtained through experimental setup involving Apache web server and clients, which acts as input to the neural network model. This method is better than existing ones because usage of RBF leads to better accuracy and speed in convergence.

  14. {mu}-PIXE analysis of monazite for total U-Th-Pb age determination

    Energy Technology Data Exchange (ETDEWEB)

    Mazzoli, C. E-mail: claudio@dmp.unipd.it; Hanchar, J.M.; Della Mea, G.; Donovan, J.J.; Stern, R.A

    2002-04-01

    U-Th-Pb chemical age determinations of monazite have been successfully determined using {mu}-PIXE at the Legnaro scanning proton microprobe facility, as well as the concentration of rare earth and other trace elements. Experimental details and the analytical procedure are described, and the results obtained are compared with data obtained using EMPA and SHRIMP II on the same analysed monazite grains, indicating that the {mu}-PIXE technique is an extremely powerful tool for monazite geochronology, both for the small error in the age determination, and in terms of detection limit, giving the possibility to date much younger monazite crystals than with EMPA. In addition, the high spatial resolution and the non-destructive character of this technique, potentially allows for the analysis of small monazite crystals along inclusion trails within porphyroblasts and/or present in the surrounding matrix, and to relate their age to that of the deformation in metamorphic rocks.

  15. Morphological and functional features of the thymus of rats of different age periods in health and at experimental immunostimulation

    Directory of Open Access Journals (Sweden)

    Bobrysheva I.V.

    2013-12-01

    Full Text Available Background. Data on the structure of the thymus of white rats with experimental immunostimulation in age aspect presented only in a few publications. Objective. Morphofunctional features of the thymus of white male rats of three age periods: pubertal, reproductive and of expressed age-related changes, administered immunomodulator imunofan were studied. Methods. Features of the histological structure of the thymus were studied using an image analyzer based on microscope Olympus CX-41. Areas of subcapsular zone, the cortex and medulla, the total number of cells, lymphocytes and epitelioreticular cells conditional on a standard area (104 μm2 were determined; limphoepitelial index was calculated. Results. The thymus has specific morphological features of the structure in each age group of animals. The thymus of rats of pubertal period has the highest morphometric parameters which somewhat decreased in animals of reproductive period. Animals with expressed age-related changes have signs of age involution of the thymus (replacing of parenchyme of the organ by adipose and connective tissue, a sharp decline in morphometric parameters of morphofunctional zones. Conclusion. Application of imunofan causes unidirectional positive changes of morphometric parameters of the thymus in the rats of all age periods on 7-60 day of observation. In animals of the reproductive period and the period of expressed age-related changes injections of immunomodulator cause a decrease in the intensity of the involutive processes in the thymus.

  16. Parameter sensitivity analysis of a simplified electrochemical and thermal model for Li-ion batteries aging

    Science.gov (United States)

    Edouard, C.; Petit, M.; Forgez, C.; Bernard, J.; Revel, R.

    2016-09-01

    In this work, a simplified electrochemical and thermal model that can predict both physicochemical and aging behavior of Li-ion batteries is studied. A sensitivity analysis of all its physical parameters is performed in order to find out their influence on the model output based on simulations under various conditions. The results gave hints on whether a parameter needs particular attention when measured or identified and on the conditions (e.g. temperature, discharge rate) under which it is the most sensitive. A specific simulation profile is designed for parameters involved in aging equations in order to determine their sensitivity. Finally, a step-wise method is followed to limit the influence of parameter values when identifying some of them, according to their relative sensitivity from the study. This sensitivity analysis and the subsequent step-wise identification method show very good results, such as a better fitting of the simulated cell voltage with experimental data.

  17. Experimental modal analysis of components of the LHC experiments

    CERN Document Server

    Guinchard, M; Catinaccio, A; Kershaw, K; Onnela, A

    2007-01-01

    Experimental modal analysis of components of the LHC experiments is performed with the purpose of determining their fundamental frequencies, their damping and the mode shapes of light and fragile detector components. This process permits to confirm or replace Finite Element analysis in the case of complex structures (with cables and substructure coupling). It helps solving structural mechanical problems to improve the operational stability and determine the acceleration specifications for transport operations. This paper describes the hardware and software equipment used to perform a modal analysis on particular structures such as a particle detector and the method of curve fitting to extract the results of the measurements. This paper exposes also the main results obtained for the LHC Experiments.

  18. Desloratadine analysis: as a pharmaceutical preparation and after accelerating ageing

    Directory of Open Access Journals (Sweden)

    Bober Katarzyna

    2015-09-01

    Full Text Available Desloratadine is a biologically active compound that is not described in the Polish Pharmacopoeia IX, hence, its study is particular important. The aim of this work was to establish a procedure for desloratadine analysis by way of HPTLC in combination with densitometry, so as to be able to ascertain its presence and degree of presence within pharmaceutical preparations. In our work, a mixture of ethyl acetate, n-butanol, ammonia and methanol was used as the mobile phase. Moreover, HPTLC plates precoated with silica gel 60F254 were also employed. The proposed method was tested and subsequently validated. Spectrodensitometric analysis was then performed to determine the optimal wavelength for the quantitative determination (λ=276 nm, and following this, a quantitative analysis of desloratadine within certain pharmaceutical preparations was performed. Our research also took into consideration an analysis of the products of desloratadine decomposition that come about as a result of the accelerated aging of its solutions. The employed procedure for accelerating the aging of such desloratadine solutions consisted of heating these at 40℃ and then irradiating the solution surfaces with UV light. The changing color of these solutions after 2 hours of exposure served to indicate that degradation had occurred. Of note: as a result of irradiation with UV light, desloratadine content was seen to decrease with time, declining to almost zero after 30 hours. However, heating a solution of desloratadine alone did not induce a change in its content. Solutions of desloratadine that had previously undergone irradiation and heating were also analyzed to ascertain whether new substances were present. For this purpose, the GC-MS process was employed. As a result of this procedure, the spectrum of the solution after aging showed the presence of several new peaks that displayed retention several times larger and smaller than the normal desloratadine peak.

  19. Statistical analysis of data from accelerated ageing tests of PES UF membranes

    NARCIS (Netherlands)

    Zondervan, Edwin; Zwijnenburg, Arie; Roffel, Brian

    2007-01-01

    In this research, membrane life-time was evaluated by means of accelerated ageing experiments. A pressure pulse unit was used to perform the ageing experiments in an accelerated way. An experimental design has been set up and four ageing factors were varied at two levels. The four ageing factors stu

  20. Analysis of the experimental positron lifetime spectra by neural networks

    Directory of Open Access Journals (Sweden)

    Avdić Senada

    2003-01-01

    Full Text Available This paper deals with the analysis of experimental positron lifetime spectra in polymer materials by using various algorithms of neural networks. A method based on the use of artificial neural networks for unfolding the mean lifetime and intensity of the spectral components of simulated positron lifetime spectra was previously suggested and tested on simulated data [Pžzsitetal, Applied Surface Science, 149 (1998, 97]. In this work, the applicability of the method to the analysis of experimental positron spectra has been verified in the case of spectra from polymer materials with three components. It has been demonstrated that the backpropagation neural network can determine the spectral parameters with a high accuracy and perform the decomposi-tion of lifetimes which differ by 10% or more. The backpropagation network has not been suitable for the identification of both the parameters and the number of spectral components. Therefore, a separate artificial neural network module has been designed to solve the classification problem. Module types based on self-organizing map and learning vector quantization algorithms have been tested. The learning vector quantization algorithm was found to have better performance and reliability. A complete artificial neural network analysis tool of positron lifetime spectra has been constructed to include a spectra classification module and parameter evaluation modules for spectra with a different number of components. In this way, both flexibility and high resolution can be achieved.

  1. An experimental test for age-related improvements in reproductive performance in a frog that cares for its young

    Science.gov (United States)

    Dugas, Matthew B.; Moore, Michael P.; Wamelink, Caitlin N.; Richards-Zawacki, Corinne L.; Martin, Ryan A.

    2015-10-01

    Reproductive performance often increases with age in long-lived iteroparous organisms, a pattern that can result from within-individual increases in effort and/or competence. In free-living populations, it is typically difficult to distinguish these mechanisms or to isolate particular features of reproduction-influencing outcomes. In captive Oophaga pumilio, a frog in which mothers provide extended offspring provisioning via trophic eggs, we experimentally manipulated the age at which females started breeding and then monitored them across repeated reproductive events. This experiment allowed us to decouple age and experience and isolate maternal care as the proximate source of any differences in performance. Younger first-time mothers produced larger broods than older first-time mothers, but did not rear more offspring to independence. Across repeated reproductive events, maternal age was unassociated with any metric of performance. At later reproductive events, however, mothers produced fewer metamorphs, and a lower proportion of individuals in their broods reached independence. These patterns suggest that performance does not improve with age or breeding experience in this frog, and that eventual declines in performance are driven by reproductive activity, not age per se. Broadly, age-specific patterns of reproductive performance may depend on the proximate mechanism by which parents influence offspring fitness and how sensitive these are to effort and competence.

  2. Experimental and CFD analysis of nozzle position of subsonic ejector

    Institute of Scientific and Technical Information of China (English)

    Xilai ZHANG; Shiping JIN; Suyi HUANG; Guoqing TIAN

    2009-01-01

    The influence of nozzle position on the performance of an ejector was analyzed qualitatively with free jet flow model. Experimental investigations and computational fluid dynamics (CFD) analysis of the nozzle position of the subsonic ejector were also conducted. The results show that there is an optimum nozzle position for the ejector. The ejecting coefficient reaches its maximum when the nozzle is positioned at the optimum and decreases when deviating. Moreover, the nozzle position of an ejector is not a fixed value, but is influenced greatly by the flow parameters. Considering the complexity of the ejector, CFD is reckoned as a useful tool in the design of ejectors.

  3. A factorial analysis experimentation of inappropriate waste disposal

    Directory of Open Access Journals (Sweden)

    S. A. Oke, K. O. Awofeso

    2006-04-01

    Full Text Available This paper presents a statistical approach to estimating the effects of psychological factors on humans due to inappropriate waste disposal in the environment. Factorial experimental analysis is combined with the concepts of transition matrix and steady state conditions. An adequate understanding into the statistical quantification of the waste disposal concept would aid policy makers in effective decision making and the proper control of environment. The feasibility of developing statistical parameters for assessing the waste disposal concept is confirmed. The work shows the novelty of the approach.

  4. Statistics for proteomics: experimental design and 2-DE differential analysis.

    Science.gov (United States)

    Chich, Jean-François; David, Olivier; Villers, Fanny; Schaeffer, Brigitte; Lutomski, Didier; Huet, Sylvie

    2007-04-15

    Proteomics relies on the separation of complex protein mixtures using bidimensional electrophoresis. This approach is largely used to detect the expression variations of proteins prepared from two or more samples. Recently, attention was drawn on the reliability of the results published in literature. Among the critical points identified were experimental design, differential analysis and the problem of missing data, all problems where statistics can be of help. Using examples and terms understandable by biologists, we describe how a collaboration between biologists and statisticians can improve reliability of results and confidence in conclusions.

  5. The Journal of The Experimental Analysis of Behavior at Fifty

    Science.gov (United States)

    Laties, Victor G

    2008-01-01

    The Journal of the Experimental Analysis of Behavior was founded in 1958 by a group of male psychologists, mainly from the northeastern USA and connected with either Harvard or Columbia. Fifty years later about 20% of both editors and authors reside outside this country and almost the same proportion is made up of women. Other changes in the journal include having its own website for more than a decade and now publishing online as well as on paper. A recent connection with PubMed Central of the National Library of Medicine has made possible the completely free electronic presentation of the entire archive of about 3,800 articles. PMID:18338677

  6. A Meta-Analysis of the Effect of Experimental Sleep Restriction on Youth's Attention and Hyperactivity.

    Science.gov (United States)

    Lundahl, Alyssa; Kidwell, Katherine M; Van Dyk, Tori R; Nelson, Timothy D

    2015-01-01

    This meta-analysis examined the effect experimental sleep restriction has on youth's attention and hyperactivity outcomes. Thirteen published studies containing 17 independent samples were included (N = 496). Random- and fixed-effects models were used to estimate pooled effect sizes and moderator effects, respectively. Results indicate that sleep-restricted youth had significantly worse attention outcomes than youth with extended sleep, but no differences were evident regarding hyperactivity. Significant moderators of this effect included age and sex. These results have important implications for both the prevention and treatment of attention problems, highlighting the need for health professionals to screen for and treat underlying sleep issues.

  7. Experimental and Analytical Analysis of Perforated Plate Aerodynamics

    Institute of Scientific and Technical Information of China (English)

    Jürgen Zierep; Rainer Bohning; Piotr Doerffer

    2003-01-01

    Perforated walls and transpiration flow play an important role in aerodynamics due to an increasing interest in application of flow control by means of blowing and/or suction. An experimental study was carried out which has led to the determination of a transpiration flow characteristics in the form of a simple formula that is very useful in modelling such flows. In connection to this relation a method of "aerodynamic porosity" determination has been proposed which is much more reliable than geometric description of the porosity. A theoretical analysis of the flow through a perforation hole was also carried out. The flow was considered as compressible and viscous. The gasdynamic analysis led us to a very similar result to the relation obtained from the experiment. The adequacy of the theoretical result is discussed in respect to the experiment.

  8. Statistics in experimental design, preprocessing, and analysis of proteomics data.

    Science.gov (United States)

    Jung, Klaus

    2011-01-01

    High-throughput experiments in proteomics, such as 2-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS), yield usually high-dimensional data sets of expression values for hundreds or thousands of proteins which are, however, observed on only a relatively small number of biological samples. Statistical methods for the planning and analysis of experiments are important to avoid false conclusions and to receive tenable results. In this chapter, the most frequent experimental designs for proteomics experiments are illustrated. In particular, focus is put on studies for the detection of differentially regulated proteins. Furthermore, issues of sample size planning, statistical analysis of expression levels as well as methods for data preprocessing are covered.

  9. Interpersonal trust: An age-period-cohort analysis revisited.

    Science.gov (United States)

    Clark, April K; Eisenstein, Marie A

    2013-03-01

    Building on the previous work of Robinson and Jackson(1), this study addresses the extent to which interpersonal trust in America is changing due to age, period, or cohort effects (APC). The importance of APC in explaining variations in trust stems from the understanding that the specific source of change can have important - albeit different and possibly, negative - consequences on society. Moreover, 3years after the previous study concluded, the country experienced the largest concerted terrorist attacks on US soil. Little is known about how the attacks affected the dynamics of interpersonal trust relative to the processes of birth, aging, and historical change - such an investigation has important implications for our understanding of the sources and consequences of interpersonal trust. Two analysis techniques for disentangling APC effects are used: constrained generalized linear models and intrinsic estimator models. The results show that while period effects are an important contributor to declining trust, the attacks exert little influence over one's decision to trust others. Also, the investigation provides further confirmation that trust in others has fallen dramatically in the US with the scarcity being led by individuals coming of age in the late 1940s, after which, trust falls with each successive cohort. If this trend continues, through the process of cohort replacement, we will become a society of "distrusters".

  10. Age determination and development of experimental methods for quaternary fault and formation

    Energy Technology Data Exchange (ETDEWEB)

    Cheong, Chang Sik; Kim, Jeong Min; Lee, S. H.; Han, J. H.; Shin, H. S.; Cheong, Y. J. [Korea Basic Science Institute, Daejeon (Korea, Republic of); Lee, H. S. [Pukyong National Univ., Busan (Korea, Republic of); Hong, D. G. [Kangwon National Univ., Gangneung (Korea, Republic of)

    2006-02-15

    Correlation of palaeo-shoreline elevations indicates that the MQt{sub 4} terrace in Suryum site has formed during MIS 5e, which is supported by stratigraphically concordant OSL ages for NQt{sub 3} terrace sediments in Yonghan area. Sedimentological features of the trench site of the Eupcheon fault suggest multiple fault movements during the Late Quaternary. All of these observations imply that uplift rate in the middle part of the coast has been much larger than that in the northern part during 125 ka {approx} 80 ka, requiring the revision of conventional view that the Korean peninsula is tectonically very stable. The ESR data suggest that the Ilkwang fault zone has been formed by the initial surface fault activity at 2-3 Ma and reactivated at least 4 times at 1.2-1.3 Ma, 1 Ma, 0.6 Ma and 0.5 Ma, with part of adjacent NNE and NE trending faults. The Eupcheon fault has been reactivated along the boundary between fault breccia originated from Cretaceous sedimentary rocks and Tertiary lithic tuff at around 2 Ma, 1.3 Ma, and 1 Ma. It has been reactivation again along the boundary between Cretaceous sandstone and fault breccia at 0.8 Ma, and between fault breccia and Tertiary lithic tuff at 0.6 Ma. During the late Quaternary after MIS 5e, the Eupcheon fault reactivated along the boundary between fault gouges, cutting Quaternary marine terrace deposits. The ESR data for the Eupcheon fault, however, should be carefully reexamined because it is probable that the samples contain clay components of weathering, not cataclastic origin. A weathering profile developed in the Suryum site was disturbed by tectonic movement that appears to be a simple one-time reverse faulting event based on field observations. A comparative analysis of the mineralogy, micromorphology, and chemistry of the weathering profile and fault gouge, however, reveals that both the microfissures in the deformed weathering profile and larger void spaces along the fault plane were filled with multi

  11. Analysis of experimental biosensor/FIA lactose measurements

    Directory of Open Access Journals (Sweden)

    Ferreira L.S.

    2003-01-01

    Full Text Available Whey is an abundant effluent in the production of cheese and casein. The biotechnological utilization of this economically important and nutritive source is limited mainly because of the presence of high percentages of lactose. This disaccharide has poor solubility, which can cause crystallization and insufficient sweetness in dairy food; additionally, part of the adult population suffers from associated lactose intolerance diseases. There are several methods to determine lactose such as spectrophotometry, polarimetry, infrared spectroscopy, titrimetry and chromatography. However these methods are tedious and time-consuming due to long sample preparation. These disadvantages stimulated the development of an enzymatic lactose biosensor. It employs two immobilized enzymes, beta-galactosidase and glucose oxidase and the quantitative analysis of lactose is based on determination of oxygen consumption in the enzymatic reaction. The influence of temperature on the biosensor signal was experimentally studied. It was observed that a nonlinear relationship exists between the electric response of the biosensor - provided by CAFCA (Computer Assisted Flow Control & Analysis - ANASYSCON, Hannover - and lactose concentration. In this work, attempts were made to correlate these variables using a simple nonlinear model and multilayered neural networks, with the latter providing the best modeling of the experimental data.

  12. Age determination and development of experimental methods for quaternary fault and formation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kwang Sik; Choi, M. S.; Kim, J. M. [Korea Basic Science Institute, Daejeon (Korea, Republic of)] (and others)

    2004-02-15

    Late cretaceous to early tertiary movement ages were constrained by Rb-Sr and K-Ar dating of fault rocks near the Uljin Nuclear Power Plants. These ages are well reproducible and consistent with geologic context. Tectonic evolution of the northeastern Yeongnam massif, the site of the Uljin Nuclear Power Plants, was investigated on the basis of Rb-Sr, Sm-Nd and Pb isotopic systematics and geochemistry of precambrian basement rocks including the Hosanri Formation, Buncheon granite gneiss, biotite granite gneiss, and Hongjesa granite. The optical ages from the Suryum fault outcrop represent the younger limit of sedimentation timing because they are simply based upon the present-day water content. The lower, Qt{sub 2} terrace at about 18m elevation is correlated with Marine Isotopic Stage (MIS) 5a, although its apparent optical age was consistently reported from 71 to 48 ka. Correlation of shoreline elevations indicates the correspondence of the Qt{sub 3a} terrace to MIS 5e, which is supported by stratigraphically concordant optical ages for aeolian sand dunes at the north of the Suryum site. This time scale yields an uplift rate of 0.266 m/ka, requiring the revision of conventional view that the Korean peninsula is tectonically very stable.

  13. High-throughput protein analysis integrating bioinformatics and experimental assays.

    Science.gov (United States)

    del Val, Coral; Mehrle, Alexander; Falkenhahn, Mechthild; Seiler, Markus; Glatting, Karl-Heinz; Poustka, Annemarie; Suhai, Sandor; Wiemann, Stefan

    2004-01-01

    The wealth of transcript information that has been made publicly available in recent years requires the development of high-throughput functional genomics and proteomics approaches for its analysis. Such approaches need suitable data integration procedures and a high level of automation in order to gain maximum benefit from the results generated. We have designed an automatic pipeline to analyse annotated open reading frames (ORFs) stemming from full-length cDNAs produced mainly by the German cDNA Consortium. The ORFs are cloned into expression vectors for use in large-scale assays such as the determination of subcellular protein localization or kinase reaction specificity. Additionally, all identified ORFs undergo exhaustive bioinformatic analysis such as similarity searches, protein domain architecture determination and prediction of physicochemical characteristics and secondary structure, using a wide variety of bioinformatic methods in combination with the most up-to-date public databases (e.g. PRINTS, BLOCKS, INTERPRO, PROSITE SWISSPROT). Data from experimental results and from the bioinformatic analysis are integrated and stored in a relational database (MS SQL-Server), which makes it possible for researchers to find answers to biological questions easily, thereby speeding up the selection of targets for further analysis. The designed pipeline constitutes a new automatic approach to obtaining and administrating relevant biological data from high-throughput investigations of cDNAs in order to systematically identify and characterize novel genes, as well as to comprehensively describe the function of the encoded proteins.

  14. Experimental Investigation on the Internal Resistance of Lithium Iron Phosphate Battery Cells during Calendar Ageing

    DEFF Research Database (Denmark)

    Stroe, Daniel Ioan; Swierczynski, Maciej Jozef; Stan, Ana-Irina;

    2013-01-01

    Lithium-ion batteries are increasingly considered for a wide area of applications because of their superior characteristics in comparisons to other energy storage technologies. However, at present, Lithium-ion batteries are expensive storage devices and consequently their ageing behavior must...... be known in order to estimate their economic viability in different application. The ageing behavior of Lithium-ion batteries is described by the fade of their discharge capacity and by the decrease of their power capability. The capability of a Lithium-ion battery to deliver or to absorb a certain power...... is directly related to its internal resistance. This work aims to investigate the dependency of the internal resistance of lithium-ion batteries on the storage temperature and on the storage time. For this purpose, accelerated ageing calendar lifetime tests were carried out over a period of one year. Based...

  15. Experimental and failure analysis of the prosthetic finger joint implants

    Science.gov (United States)

    Naidu, Sanjiv H.

    Small joint replacement arthroplasty of the hand is a well accepted surgical procedure to restore function and cosmesis in an individual with a crippled hand. Silicone elastomers have been used as prosthetic material in various small hand joints for well over three decades. Although the clinical science aspects of silicone elastomer failure are well known, the physical science aspects of prosthetic failure are scant and vague. In the following thesis, using both an animal model, and actual retrieved specimens which have failed in human service, experimental and failure analysis of silicone finger joints are presented. Fractured surfaces of retrieved silicone trapezial implants, and silicone finger joint implants were studied with both FESEM and SEM; the mode of failure for silicone trapezium is by wear polishing, whereas the finger joint implants failed either by fatigue fracture or tearing of the elastomer, or a combination of both. Thermal analysis revealed that the retrieved elastomer implants maintained its viscoelastic properties throughout the service period. In order to provide for a more functional and physiologic arthroplasty a novel finger joint (Rolamite prosthesis) is proposed using more recently developed thermoplastic polymers. The following thesis also addresses the outcome of the experimental studies of the Rolamite prosthesis in a rabbit animal model, in addition to the failure analysis of the thermoplastic polymers while in service in an in vivo synovial environment. Results of retrieved Rolamite specimens suggest that the use for thermoplastic elastomers such as block copolymer based elastomers in a synovial environment such as a mammalian joint may very well be limited.

  16. Comparison of real-life accidental falls in older people with experimental falls in middle-aged test subjects.

    Science.gov (United States)

    Kangas, M; Vikman, I; Nyberg, L; Korpelainen, R; Lindblom, J; Jämsä, T

    2012-03-01

    Falling is a common accident among older people. Automatic fall detectors are one method of improving security. However, in most cases, fall detectors are designed and tested with data from experimental falls in younger people. This study is one of the first to provide fall-related acceleration data obtained from real-life falls. Wireless sensors were used to collect acceleration data during a six-month test period in older people. Data from five events representing forward falls, a sideways fall, a backwards fall, and a fall out of bed were collected and compared with experimental falls performed by middle-aged test subjects. The signals from real-life falls had similar features to those from intentional falls. Real-life forward, sideways and backward falls all showed a pre impact phase and an impact phase that were in keeping with the model that was based on experimental falls. In addition, the fall out of bed had a similar acceleration profile as the experimental falls of the same type. However, there were differences in the parameters that were used for the detection of the fall phases. The beginning of the fall was detected in all of the real-life falls starting from a standing posture, whereas the high pre impact velocity was not. In some real-life falls, multiple impacts suggested protective actions. In conclusion, this study demonstrated similarities between real-life falls of older people and experimental falls of middle-aged subjects. However, some fall characteristics detected from experimental falls were not detectable in acceleration signals from corresponding heterogeneous real-life falls.

  17. Identifying Effective Spelling Interventions Using a Brief Experimental Analysis and Extended Analysis

    Science.gov (United States)

    McCurdy, Merilee; Clure, Lynne F.; Bleck, Amanda A.; Schmitz, Stephanie L.

    2016-01-01

    Spelling is an important skill that is crucial to effective written communication. In this study, brief experimental analysis procedures were used to examine spelling instruction strategies (e.g., whole word correction; word study strategy; positive practice; and cover, copy, and compare) for four students. In addition, an extended analysis was…

  18. Experimental Testing for Stability Analysis of Distributed Energy Resources Components with Storage Devices and Loads

    DEFF Research Database (Denmark)

    Mihet-Popa, Lucian; Groza, Voicu; Isleifsson, Fridrik Rafn

    2012-01-01

    Experimental Testing for Stability Analysis of Distributed Energy Resources Components with Storage Devices and Loads......Experimental Testing for Stability Analysis of Distributed Energy Resources Components with Storage Devices and Loads...

  19. Rules Compliance and Age: Experimental Evidence with Fishers from the Amazon River

    Directory of Open Access Journals (Sweden)

    Maria Alejandra Velez

    2013-09-01

    Full Text Available We report the results of common-pool resource economic experiments conducted with indigenous communities in the Colombian Amazon. The experiments recreate two contexts: a limited open access with no institutions regulating the fisheries and a nonmonetary external regulation that limits individual extraction when a fisher is found to be overextracting. We find that variables that did not explain behavior under limited open access do so under the regulatory institution. In particular, when the nonmonetary external regulation was introduced, we found a nonlinear significant effect of age on individual harvest. This result implies a negative relationship between age and individual extraction that reaches a peak around age 54. Our results suggest that in our sample, age groups react differently to an institution aimed to manage the fishery and open a discussion regarding the role of older fishers when a new regulation is introduced to manage natural resources. Their role could go beyond the dissemination of traditional knowledge and cultural systems since older fishers could be key actors in disseminating and adapting new institutions.

  20. Age-related changes of dental pulp tissue after experimental tooth movement in rats

    NARCIS (Netherlands)

    Von Bohl, Martina; Ren, Yijin; Kuijpers-Jagtman, Anne M.; Fudalej, Piotr S.; Maltha, Jaap C.

    2016-01-01

    It is generally accepted that the effect of orthodontic tooth movement on the dental, pulp in adolescents is reversible and that it has no long-lasting effect on pulpal physiology. However, it is not clear yet if the same conclusion is also valid for adult subjects. Thus, in two groups of rats, aged

  1. Experimental study on ultrasonic pulse velocity evaluation of the microstructure of cementitious material at early age

    NARCIS (Netherlands)

    Guang Ye; Van Breugel, K.; Fraaij, A.L.A.

    2001-01-01

    This paper describes an ultrasonic experimental set-up to monitor the development of the microstructure of fresh concrete at different temperatures (isothermal curing at 10, 20, 30 and 50 °C) and water/cement ratios (0.40, 0.45 and 0.55). The Ultrasonic Pulse Velocity (UPV) is used as an indication

  2. Aging does not enhance experimental cigarette smoke-induced COPD in the mouse.

    Directory of Open Access Journals (Sweden)

    Steven Zhou

    Full Text Available It has been proposed that the development of COPD is driven by premature aging/premature senescence of lung parenchyma cells. There are data suggesting that old mice develop a greater inflammatory and lower anti-oxidant response after cigarette smoke compared to young mice, but whether these differences actually translate into greater levels of disease is unknown. We exposed C57Bl/6 female mice to daily cigarette smoke for 6 months starting at age 3 months (Ayoung@ or age 12 months (Aold@, with air-exposed controls. There were no differences in measures of airspace size between the two control groups and cigarette smoke induced exactly the same amount of emphysema in young and old. The severity of smoke-induced small airway remodeling using various measures was identical in both groups. Smoke increased numbers of tissue macrophages and neutrophils and levels of 8-hydroxyguanosine, a marker of oxidant damage, but there were no differences between young and old. Gene expression studies using laser capture microdissected airways and parenchyma overall showed a trend to lower levels in older animals and a somewhat lesser response to cigarette smoke in both airways and parenchyma but the differences were usually not marked. Telomere length was greatest in young control mice and was decreased by both smoking and age. The senescence marker p21(Waf1 was equally upregulated by smoke in young and old, but p16(INK4a, another senescence marker, was not upregulated at all. We conclude, in this model, animal age does not affect the development of emphysema and small airway remodeling.

  3. Experimental Analysis of Jet Ejector by Forced Draught

    Directory of Open Access Journals (Sweden)

    N. Alagumurthy

    2012-08-01

    Full Text Available A jet compressor uses a jet of primary fluid to induce a peripheral secondary flow often against back pressure. Expansion of primary jet produces a partial vacuum near the secondary flow inlet creating a rapid re-pressurization of the mixed fluids followed by a diffuser to increase the pressure at the exit. Using the geometrical design parameters obtained by solving the governing equations, a CFD analysis is made using the FLUENT software to evaluate the optimum entrainment ratio that could be achieved for a given set of operating conditions, where the entrainment ratio (ER is the ratio of the mass flow rate of the secondary fluid (propelled stream to the primary fluid (motive fluid. In this paper a jet compressor’s performance analysis is made using irreversibility characteristics .the various losses that occurs in different regions of jet compressor are quantified. Effort is made to increase the efficiency of jet compressor by reducing the losses based on minimization of entropy method. In order to match the ER that is achievable theoretically, an effort is made to force (charge the propelled stream using a blower. So that the momentum difference between the motive and the propelled fluid is minimized. Experimental results obtained using the forced draft system is found to match the results obtained from the FLUENT analysis.

  4. Numerical and Experimental Stress Analysis of a Composite Leaf Spring

    Directory of Open Access Journals (Sweden)

    Kaveri A. Katake

    2016-10-01

    Full Text Available Automobile sector is always focusing on enhancing level of comfort, fuel economy, customer satisfaction and safety. Vehicle weight reduction increases the overall fuel efficiency. Use of composite materials has made it possible to reduce the weight of the vehicle, without reduction in load carrying capacity. Now a day's manufacturers and researchers are trying to replace conventional material parts with composites. The composite materials have more elastic strain energy storage capacity and high strength to weight ratio as compared to steel. This paper is related to Numerical and experimental strength analysis of suspension leaf springs for a light motor vehicle made of composite materials. Two materials Glass Fiber Reinforced Plastic (GFRP and Carbon Fiber Reinforced Plastic (CFRP are selected for manufacturing of leaf spring. The strength of these composite depends on angle orientation, volume to weight ratio of reinforcement and length to depth ratio of fiber. In this work two leaf springs made of GFRP and a sandwich of CFRP and GFRP are developed. Numerical and experimental static stress analyses are carried out for these two springs. These results are compared with analytical results of conventional metal spring. The comparison shows that composite material springs have compatible strength to withstand load. Comparative results for weight, cost and deformation are presented at the end of the paper.

  5. EXPERIMENTAL INVESTIGATION & NUMERICAL ANALYSIS OF COMPOSITE LEAF SPRING

    Directory of Open Access Journals (Sweden)

    K. K. JADHAO,

    2011-06-01

    Full Text Available The Automobile Industry has shown keen interest for replacement of steel leaf spring with that of glass fiber composite leaf spring, since the composite material has high strength to weight ratio, good corrosion resistance and tailor-able properties. The objective of present study was to replace material for leaf spring. In present study the material selected was glass fiber reinforced plastic (GFRP and the polyester resin (NETPOL 1011 can be used which was more economical this will reduce total cost of composite leaf spring. A spring with constant width and thickness was fabricated by hand lay-up technique which was very simple and economical. The experiments were conducted on UTM and numerical analysis was done via (FEA using ANSYS software. Stresses and deflection results were verified for analytical and experimental results. Result shows that, the composite spring has stresses much lower than steel leaf spring and weight of composite spring was nearly reduced up to 85%.

  6. THE STRUCTURE ANALYSIS OF POPULATION BY AGE GROUPS IN THE RURAL AREAS OF BUCOVINA

    Directory of Open Access Journals (Sweden)

    NICOLETA ILEANA MORAR (BUMBU

    2015-12-01

    Full Text Available The structure analysis of population by age groups in the rural area of Bucovina desires to create a recent image of the rural population by age groups in the region of Bucovina , provided that after the year 2000 have occurred socio – economic changes with repercussions on the demographic component. The structure analysis by age group will be based on the share of population indicators on the major age groups, the share of population by age and quinquennial gender illustrated by age pyramid, the index of demographic aging and age-dependency ratio. This study is definitely needed in forecasting future regional development objectives and measures.

  7. Modeling and experimental vibration analysis of nanomechanical cantilever active probes

    Science.gov (United States)

    Salehi-Khojin, Amin; Bashash, Saeid; Jalili, Nader

    2008-08-01

    Nanomechanical cantilever (NMC) active probes have recently received increased attention in a variety of nanoscale sensing and measurement applications. Current modeling practices call for a uniform cantilever beam without considering the intentional jump discontinuities associated with the piezoelectric layer attachment and the NMC cross-sectional step. This paper presents a comprehensive modeling framework for modal characterization and dynamic response analysis of NMC active probes with geometrical discontinuities. The entire length of the NMC is divided into three segments of uniform beams followed by applying appropriate continuity conditions. The characteristics matrix equation is then used to solve for system natural frequencies and mode shapes. Using an equivalent electromechanical moment of a piezoelectric layer, forced motion analysis of the system is carried out. An experimental setup consisting of a commercial NMC active probe from Veeco and a state-of-the-art microsystem analyzer, the MSA-400 from Polytec, is developed to verify the theoretical developments proposed here. Using a parameter estimation technique based on minimizing the modeling error, optimal values of system parameters are identified. Mode shapes and the modal frequency response of the system for the first three modes determined from the proposed model are compared with those obtained from the experiment and commonly used theory for uniform beams. Results indicate that the uniform beam model fails to accurately predict the actual system response, especially in multiple-mode operation, while the proposed discontinuous beam model demonstrates good agreement with the experimental data. Such detailed and accurate modeling framework can lead to significant enhancement in the sensitivity of piezoelectric-based NMC sensors for use in variety of sensing and imaging applications.

  8. An Experimental Research into the Anti-aging Effects of Radix Arctii Lappae

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Purpose: To delve into the anti-aging effects and mechanism of Niubanggen (牛蒡根Radix Arctii Lappae). Method: The activity of SOD and the content of MDA and lipofuscin in the tissues of the liver,brain and blood serum of the lab rats were observed 30 days after they had been fed with the Niubanggen decoction. Result: The activity of SOD in the liver tissue and blood serum of the decoction-fed lab rats was improved dramatically (P<0.05 or P<0.01), the content of MDA in the brain tissue and blood serum lowered obviously (P<0.05 or P<0.01), and the content of lipofuscin dropped distinctly (P<0.01). Conclusion: The mechanism of the anti-aging effects of the Niubanggen is mainly obtained by raising the activity of SOD and reducing the contents of MDA and lipofuscin.

  9. Experimental investigation of fiberglass sandwich composite bending behaviour after severe aging condition

    Science.gov (United States)

    Gambaro, Carla; Lertora, Enrico; Mandolfino, Chiara

    2016-10-01

    Fiber Reinforced Polymer (FRP) sandwich panels are increasing their application as structural and non-structural components in all kinds of construction. By varying the material and thickness of core and face sheets, it is possible to obtain sandwich structures with different properties and performance. In particular, their advantages as lightweight and high mechanical properties make them extremely suitable for the transport industry. One of the most critical aspects regarding composite materials for engineering application is their performance after hygrothermal aging. The panels used in this study are composed of low density core, made by thermosetting resin foam with microspheres and glass fibers rolled until obtaining the required thickness, and two face sheets of the same material but realized in high density. In this study, the authors focused on the bending behaviour of this kind of sandwich panel, as received and after severe aging cycles.

  10. Eleutheroside B or E enhances learning and memory in experimentally aged rats★

    OpenAIRE

    Huang, Debin; Hu, Zehua; Yu, Zhaofen

    2013-01-01

    Eleutheroside B or E, the main component of Acanthopanax, can relieve fatigue, enhance memory, and improve human cognition. Numerous studies have confirmed that high doses of acetylcholine significantly attenuate clinical symptoms and delay the progression of Alzheimer's disease. The present study replicated a rat model of aging induced by injecting quinolinic acid into the hippocampal CA1 region. These rats were intraperitoneally injected with low, medium and high doses of eleutheroside B or...

  11. [Efficiency of mildronate in rats of different age with experimental-induced myocardial ischemia].

    Science.gov (United States)

    Kukes, V G; Zhernakova, N I; Gorbach, T V; Romashchenko, O V; Rumbesht, V V

    2013-01-01

    Under experimental myocardial ischemia in rats of 10 months treatment with mildronate resulted in essential changes in metabolism of cardiomyocites. This includes stimulation of aerobic and anaerobic ways of power supply of heart cells: activation of glycolysis, oxidative phosphorylation and oxidative pyruvate decarboxylation with restoration of adenosine triphosphate pool to intact rats level in myocardium, serum and erythrocytes with signs of stabilization of cardiomyocytes membranes and essential decrease of tissue hypoxia. Introduction of mildronate to old rats (24 months) with an experimental myocardium ischemia was accompanied by lesser expressed changes of metabolism: activation of glycolysis and oxidative pyruvate decarboxylation without stimulation of Crebs' cycle enzymes. This became sufficient for restoration of adenosine triphosphate pool in myocardium without change of its quantity in serum and erythrocytes with signs of stabilization of cardiomyocytes membranes and moderate reduction of tissue hypoxia degree.

  12. Age-related changes of dental pulp tissue after experimental tooth movement in rats

    Directory of Open Access Journals (Sweden)

    Martina Von Böhl

    2016-01-01

    Full Text Available It is generally accepted that the effect of orthodontic tooth movement on the dental pulp in adolescents is reversible and that it has no long-lasting effect on pulpal physiology. However, it is not clear yet if the same conclusion is also valid for adult subjects. Thus, in two groups of rats, aged 6 and 40 weeks respectively, 3 molars at one side of the maxilla were moved together in a mesial direction with a standardized orthodontic appliance delivering a force of 10 cN. The contralateral side served as a control. Parasagittal histological sections were prepared after tooth movement for 1, 2, 4, 8, and 12 weeks. The pulp tissue was characterized for the different groups, with special emphasis on cell density, inflammatory cells, vascularity, and odontoblasts. Dimensions of dentin and the pulpal horns was determined and related with the duration of orthodontic force application and age ware evaluated. We found that neither in young nor in adult rats, force application led to long-lasting or irreversible changes in pulpal tissues. Dimensional variables showed significant age-related changes. In conclusion, orthodontic tooth movement per se has no long-lasting or irreversible effect on pulpal tissues, neither in the young nor in the adult animals.

  13. The decay of 'mesotrons' (1939-1943), experimental particle physics in the age of innocence

    Science.gov (United States)

    Rossi, B.

    1983-01-01

    An account is given of the experimental work carried out by the author and his associates during the years 1939 through 1943, which produced the first unambiguous evidence of the spontaneous decay of 'mesotrons', showed that this decay occurred according to an exponential law, as expected, and measured the mean life with a 3 percent accuracy. A byproduct of this work was a verification of the relativistic equation for the dilation of time intervals. Previously announced in STAR as N81-76151

  14. Meta-analysis of the performance variation in broilers experimentally challenged by Eimeria spp.

    Science.gov (United States)

    Kipper, Marcos; Andretta, Ines; Lehnen, Cheila Roberta; Lovatto, Paulo Alberto; Monteiro, Silvia Gonzalez

    2013-09-01

    A meta-analysis was carried out to (1) study the relation of the variation in feed intake and weight gain in broilers infected with Eimeria acervulina, Eimeria maxima, Eimeria tenella, or a Pool of Eimeria species, and (2) to identify and to quantify the effects involved in the infection. A database of articles addressing the experimental infection with Coccidia in broilers was developed. These publications must present results of animal performance (weight gain, feed intake, and feed conversion ratio). The database was composed by 69 publications, totalling around 44 thousand animals. Meta-analysis followed three sequential analyses: graphical, correlation, and variance-covariance. The feed intake of the groups challenged by E. acervulina and E. tenella did not differ (P>0.05) to the control group. However, the feed intake in groups challenged by E. maxima and Pool showed an increase of 8% and 5% (PEimeria species, animal age, sex, and genetic line. In general the age effect is superior to the challenge effect, showing that age at the challenge is important to determine the impact of Eimeria infection.

  15. Analysis of Deformation in Inconel 718 When the Stress Anomaly and Dynamic Strain Aging Coexist

    Science.gov (United States)

    Follansbee, Paul S.

    2016-09-01

    Deformation in Inconel 718 in the presence of combined effects of the stress anomaly and dynamic strain aging is analyzed according to an internal state variable model formulation. The analysis relies on the availability of experimental data in regimes of behavior where both the stress anomaly and dynamic strain aging are absent. A model that introduces two internal state variables—one characterizing interactions of dislocations with solute atoms and one characterizing interaction of dislocations with precipitates—is shown to adequately describe the temperature and strain-rate dependence of the yield stress in several superalloy systems. Strain hardening is then added with a third internal state variable to enable description of the full stress-strain curve. These equations are extrapolated into regimes where the stress anomaly and dynamic strain aging are present to identify signatures of their effects and to compare to similar analyses in a variety of metal systems. Dynamic strain aging in Inconel 718 follows similar trends to those observed previously. The magnitude of the stress anomaly tracks measurements of stress vs test temperature in pure Ni3Al. Several trends in the strain-rate sensitivity of elevated temperature deformation in superalloys are identified based on limited availability of measurements over a wide range of strain rates or tests using strain-rate changes.

  16. Experimental analysis of particle sizes for PIV measurements

    Science.gov (United States)

    van Overbrüggen, Timo; Klaas, Michael; Soria, Julio; Schröder, Wolfgang

    2016-09-01

    The right choice of seeding particles strongly influences the outcome of a particle-image velocimetry (PIV) measurement. Particles have to scatter enough light to be seen by cameras and follow the flow faithfully. As the flow following behavior depends on the inertia and therefore the size of the particle, smaller particles are desirable. Unfortunately, larger particles possess better light scattering behavior, which is especially important for volumetric PIV measurements. In this paper, the particle response of two exemplary solid particles to an oscillatory air flow created by a piston movement is analyzed and compared to analytic results by Hjelmfelt and Mockros (1966 Appl. Sci. Res. 16 149-61) concerning phase lag and amplitude ratio between particle movement and flow field. To achieve realistic experimental boundary conditions, polydispersed particles are used for the analysis. The analytic results show a strong dependence on the diameter. That is, using the volumetric mean diameter an overestimation of the phase lag of the particles is determined, whereas an underestimation of phase lag is computed for the number mean diameter. Hence, for polydispersed particles a more general analysis than that based on the particle mean diameter is required to determine in detail the particle following behavior.

  17. Acoustic analysis in Mudejar-Gothic churches: experimental results.

    Science.gov (United States)

    Galindo, Miguel; Zamarreño, Teófilo; Girón, Sara

    2005-05-01

    This paper describes the preliminary results of research work in acoustics, conducted in a set of 12 Mudejar-Gothic churches in the city of Seville in the south of Spain. Despite common architectural style, the churches feature individual characteristics and have volumes ranging from 3947 to 10 708 m3. Acoustic parameters were measured in unoccupied churches according to the ISO-3382 standard. An extensive experimental study was carried out using impulse response analysis through a maximum length sequence measurement system in each church. It covered aspects such as reverberation (reverberation times, early decay times), distribution of sound levels (sound strength); early to late sound energy parameters derived from the impulse responses (center time, clarity for speech, clarity, definition, lateral energy fraction), and speech intelligibility (rapid speech transmission index), which all take both spectral and spatial distribution into account. Background noise was also measured to obtain the NR indices. The study describes the acoustic field inside each temple and establishes a discussion for each one of the acoustic descriptors mentioned by using the theoretical models available and the principles of architectural acoustics. Analysis of the quality of the spaces for music and speech is carried out according to the most widespread criteria for auditoria.

  18. Acoustic analysis in Mudejar-Gothic churches: Experimental results

    Science.gov (United States)

    Galindo, Miguel; Zamarreño, Teófilo; Girón, Sara

    2005-05-01

    This paper describes the preliminary results of research work in acoustics, conducted in a set of 12 Mudejar-Gothic churches in the city of Seville in the south of Spain. Despite common architectural style, the churches feature individual characteristics and have volumes ranging from 3947 to 10 708 m3. Acoustic parameters were measured in unoccupied churches according to the ISO-3382 standard. An extensive experimental study was carried out using impulse response analysis through a maximum length sequence measurement system in each church. It covered aspects such as reverberation (reverberation times, early decay times), distribution of sound levels (sound strength); early to late sound energy parameters derived from the impulse responses (center time, clarity for speech, clarity, definition, lateral energy fraction), and speech intelligibility (rapid speech transmission index), which all take both spectral and spatial distribution into account. Background noise was also measured to obtain the NR indices. The study describes the acoustic field inside each temple and establishes a discussion for each one of the acoustic descriptors mentioned by using the theoretical models available and the principles of architectural acoustics. Analysis of the quality of the spaces for music and speech is carried out according to the most widespread criteria for auditoria. .

  19. Justification for experimental methods for circuit training aerobics classes first mature age women

    Directory of Open Access Journals (Sweden)

    Martyniuk O.V.

    2014-11-01

    Full Text Available Purpose: develop and validate a methodology for circuit training aerobics. Methodology focused on improving physical health first mature age women. Material : a study was conducted with 81 women (age 21 - 35 years. Results : justified the means and methods of circuit training, the duration of the structural components, the rational parameters of physical activity, pulse modes. Depending on the physical health of women developed a set of circuit training for the main part of the session. Complex circuit training consists of 2 series, active rest interval between 3 minutes. Duration of employment in one series of 23 minutes. Exercises are performed at 5 locations: 3 - aerobic (3x5 min, 2 - power (2x4 min. The total duration of training - 49 minutes. The intensity of the training load is regulated by the level of physical health and the maximum test results. Conclusions : The positive changes morphofunctional indicators show an increase in the body's bioenergy and women transition to a higher level of physical health.

  20. Removal of polycyclic aromatic hydrocarbons from aged-contaminated soil using cyclodextrins: Experimental study

    Energy Technology Data Exchange (ETDEWEB)

    Viglianti, Christophe [Laboratoire d' Analyse Environnementale des Procedes et des Systemes Industriels - INSA de Lyon, 9, rue de la Physique - 69621 Villeurbanne Cedex (France); Centre Sciences, Information et Technologies pour l' Environnement (SITE) - ENS de Mines de Saint Etienne, 158 cours Fauriel - 42023 Saint Etienne Cedex 2 (France); Hanna, Khalil [Laboratoire d' Analyse Environnementale des Procedes et des Systemes Industriels - INSA de Lyon, 9, rue de la Physique - 69621 Villeurbanne Cedex (France)]. E-mail: khalilhanna@hotmail.com; Brauer, Christine de [Laboratoire d' Analyse Environnementale des Procedes et des Systemes Industriels - INSA de Lyon, 9, rue de la Physique - 69621 Villeurbanne Cedex (France); Germain, Patrick [Laboratoire d' Analyse Environnementale des Procedes et des Systemes Industriels - INSA de Lyon, 9, rue de la Physique - 69621 Villeurbanne Cedex (France)

    2006-04-15

    The removal of polycyclic aromatic hydrocarbons (PAHs) from soil using water as flushing agent is relatively ineffective due to their low aqueous solubility. However, addition of cyclodextrin (CD) in washing solutions has been shown to increase the removal efficiency several times. Herein are investigated the effectiveness of cyclodextrin to remove PAH occurring in industrially aged-contaminated soil. {beta}-Cyclodextrin (BCD), hydroxypropyl-{beta}-cyclodextrin (HPCD) and methyl-{beta}-cyclodextrin (MCD) solutions were used for soil flushing in column test to evaluate some influent parameters that can significantly increase the removal efficiency. The process parameters chosen were CD concentration, ratio of washing solution volume to soil weight, and temperature of washing solution. These parameters were found to have a significant and almost linear effect on PAH removal from the contaminated soil, except the temperature where no significant enhancement in PAH extraction was observed for temperature range from 5 to 35 {sup o}C. The PAHs extraction enhancement factor compared to water was about 200. - An innovative method using a biodegradable and non-toxic flushing agent for the depollution of industrially aged-contaminated soil.

  1. Eleutheroside B or E enhances learning and memory in experimentally aged rats★

    Science.gov (United States)

    Huang, Debin; Hu, Zehua; Yu, Zhaofen

    2013-01-01

    Eleutheroside B or E, the main component of Acanthopanax, can relieve fatigue, enhance memory, and improve human cognition. Numerous studies have confirmed that high doses of acetylcholine significantly attenuate clinical symptoms and delay the progression of Alzheimer's disease. The present study replicated a rat model of aging induced by injecting quinolinic acid into the hippocampal CA1 region. These rats were intraperitoneally injected with low, medium and high doses of eleutheroside B or E (50, 100, 200 mg/kg), and rats injected with Huperzine A or PBS were used as controls. At 4 weeks after administration, behavioral tests showed that the escape latencies and errors in searching for the platform in a Morris water maze were dose-dependently reduced in rats treated with medium and high-dose eleutheroside B or E. Hematoxylin-eosin staining showed that the number of surviving hippocampal neurons was greater and pathological injury was milder in three eleutheroside B or E groups compared with model group. Hippocampal homogenates showed enhanced cholinesterase activity, and dose-dependent increases in acetylcholine content and decreases in choline content following eleutheroside B or E treatment, similar to those seen in the Huperzine A group. These findings indicate that eleutheroside B or E improves learning and memory in aged rats. These effects of eleutheroside B or E may be mediated by activation of cholinesterase or enhanced reuse of choline to accelerate the synthesis of acetylcholine in hippocampal neurons. PMID:25206404

  2. Eleutheroside B or E enhances learning and memory in experimentally aged rats.

    Science.gov (United States)

    Huang, Debin; Hu, Zehua; Yu, Zhaofen

    2013-04-25

    Eleutheroside B or E, the main component of Acanthopanax, can relieve fatigue, enhance memory, and improve human cognition. Numerous studies have confirmed that high doses of acetylcholine significantly attenuate clinical symptoms and delay the progression of Alzheimer's disease. The present study replicated a rat model of aging induced by injecting quinolinic acid into the hippocampal CA1 region. These rats were intraperitoneally injected with low, medium and high doses of eleutheroside B or E (50, 100, 200 mg/kg), and rats injected with Huperzine A or PBS were used as controls. At 4 weeks after administration, behavioral tests showed that the escape latencies and errors in searching for the platform in a Morris water maze were dose-dependently reduced in rats treated with medium and high-dose eleutheroside B or E. Hematoxylin-eosin staining showed that the number of surviving hippocampal neurons was greater and pathological injury was milder in three eleutheroside B or E groups compared with model group. Hippocampal homogenates showed enhanced cholinesterase activity, and dose-dependent increases in acetylcholine content and decreases in choline content following eleutheroside B or E treatment, similar to those seen in the Huperzine A group. These findings indicate that eleutheroside B or E improves learning and memory in aged rats. These effects of eleutheroside B or E may be mediated by activation of cholinesterase or enhanced reuse of choline to accelerate the synthesis of acetylcholine in hippocampal neurons.

  3. Eleutheroside B or E enhances learning and memory in experimentally aged rats

    Institute of Scientific and Technical Information of China (English)

    Debin Huang; Zehua Hu; Zhaofen Yu

    2013-01-01

    Eleutheroside B or E, the main component of Acanthopanax, can relieve fatigue, enhance memory, and improve human cognition. Numerous studies have confirmed that high doses of acetylcholine significantly attenuate clinical symptoms and delay the progression of Alzheimer's disease. The present study replicated a rat model of aging induced by injecting quinolinic acid into the hippocampal CA1 region. These rats were intraperitoneally injected with low, medium and high doses of eleutheroside B or E (50, 100, 200 mg/kg), and rats injected with Huperzine A or PBS were used as controls. At 4 weeks after administration, behavioral tests showed that the escape latencies and errors in searching for the platform in a Morris water maze were dose-dependently reduced in rats treated with medium and high-dose eleutheroside B or E. Hematoxylin-eosin staining showed that the number of surviving hippocampal neurons was greater and pathological injury was milder in three eleutheroside B or E groups compared with model group. Hippocampal homogenates showed enhanced cholinesterase activity, and dose-dependent increases in acetylcholine content and decreases in choline content following eleutheroside B or E treatment, similar to those seen in the Huperzine A group. These findings indicate that eleutheroside B or E improves learning and memory in aged rats. These effects of eleutheroside B or E may be mediated by activation of cholinesterase or enhanced reuse of choline to accelerate the synthesis of acetylcholine in hippocampal neurons.

  4. Age differences in the neural representation of working memory revealed by multi-voxel pattern analysis.

    Directory of Open Access Journals (Sweden)

    Joshua eCarp

    2010-11-01

    Full Text Available Working memory function declines across the lifespan. Computational models of aging attribute such memory impairments to reduced distinctiveness between neural representations of different mental states in old age, a phenomenon termed dedifferentiation. These models predict that neural distinctiveness should be reduced uniformly across experimental conditions in older adults. In contrast, the Compensation-Related Utilization of Neural Circuits Hypothesis (CRUNCH model predicts that the distinctiveness of neural representations should be increased in older adults (relative to young adults at low levels of task demand but reduced at high levels of demand. The present study used multi-voxel pattern analysis (MVPA to measure the effects of age and task demands on the distinctiveness of the neural representations of verbal and visuospatial working memory. Neural distinctiveness was estimated separately for memory encoding, maintenance, and retrieval, and for low, medium, and high memory loads. Results from sensory cortex during encoding and retrieval were consistent with the dedifferentiation hypothesis: distinctiveness of visual cortical representations during these phases was uniformly reduced in older adults, irrespective of memory load. However, maintenance-related responses in prefrontal and parietal regions yielded a strikingly different pattern of results. At low loads, older adults showed higher distinctiveness than younger adults; at high loads, this pattern reversed, such that distinctiveness was higher in young adults. This interaction between age group and memory load is at odds with the dedifferentiation hypothesis but consistent with CRUNCH. In sum, our results provide partial support for both dedifferentiation- and compensation-based models; we argue that comprehensive theories of cognitive aging must incorporate aspects of both models to fully explain complex patterns of age-related neuro-cognitive change.

  5. [Composition and metabolism of extremely low-density lipoproteins in normal rabbits of different age and under experimental atherosclerosis].

    Science.gov (United States)

    Chaialo, P P

    1981-01-01

    The lipid composition and protein content in extremely low-density lipoproteids. lipoproteid-lypase activity and breakdown dynamics of the mentioned [3H]cholesterol-labelled lipoproteids are studied in blood of young and old rabbits in norm and under experimental atherosclerosis. It is shown that in normal animals the content of all lipid components and protein decreases with ageing in the fraction of extremely low-density lipoproteids isolated from blood serum. The activity of lipoproteid lypase and breakdown of intravenously injected labelled extremely low-density lipoproteids are lowered in old animals as well. Under experimental atherosclerosis in extremely low-density lipoproteids there occurs accumulation of cholesterol esters in considerable amounts, the breakdown of the class lipoproteids is slown down. The enzymic activity manifests no significant changes in comparison with the norm. Disturbances in the composition of lipoproteids and their metabolism with the studied pathology are more pronounced in old rabbits than in young ones.

  6. Experimental and modelling investigation of surface EMG spike analysis.

    Science.gov (United States)

    Gabriel, David A; Christie, Anita; Inglis, J Greig; Kamen, Gary

    2011-05-01

    A pattern classification method based on five measures extracted from the surface electromyographic (sEMG) signal is used to provide a unique characterization of the interference pattern for different motor unit behaviours. This study investigated the sensitivity of the five sEMG measures during the force gradation process. Tissue and electrode filtering effects were further evaluated using a sEMG model. Subjects (N=8) performed isometric elbow flexion contractions from 0 to 100% MVC. The sEMG signals from the biceps brachii were recorded simultaneously with force. The basic building block of the sEMG model was the detection of single fibre action potentials (SFAPs) through a homogeneous, equivalent isotropic, infinite volume conduction medium. The SFAPs were summed to generate single motor unit action potentials. The physiologic properties from a well-known muscle model and motor unit recruitment and firing rate schemes were combined to generate synthetic sEMG signals. The following pattern classification measures were calculated: mean spike amplitude, mean spike frequency, mean spike slope, mean spike duration, and the mean number of peaks per spike. Root-mean-square amplitude and mean power frequency were also calculated. Taken together, the experimental data and modelling analysis showed that below 50% MVC, the pattern classification measures were more sensitive to changes in force than traditional time and frequency measures. However, there are additional limitations associated with electrode distance from the source that must be explored further. Future experimental work should ensure that the inter-electrode distance is no greater than 1cm to mitigate the effects of tissue filtering.

  7. Differentiation, ageing, and terminal differentiation: a semantic analysis.

    Science.gov (United States)

    Reiner, J M

    1983-12-21

    The largely unsolved problems in the theoretical analysis of differentiation and ageing involve a substantial component of linguistic (semantic) difficulties. Some of these are simple traps of ambiguity, resulting from metaphorical or analogical employment of established terms--for example, "terminal differentiation" (loss of division potential in vitro) as a borrowing from "differentiation" as used by developmental biologists, or "commitment" by analogy with "determination". Some difficulties represent a failure to adopt (at least provisionally) an operational (empirical) view--for example, failure to ask what is the nature of the evidence for the view that a fertilized ovum is totipotential, or to scrutinize the evidence for the view that cells "terminally differentiated" in vitro in a conventional medium are in fact moribund under all conditions, or to examine more closely the view that the differentiated state and the cycling state are mutually exclusive. With respect to the problem of ageing, we review some of the critical experiments on "terminal differentiation" or "clonal senescence". We then proceed to consider some of the models that have been proposed, including a molecular model proposed by the author which appears to overcome some of the objections to other models. Some of the models exemplify the results of what are ultimately semantic vices. The problems with which these remarks began should indeed yield to the immense and novel resources of molecular biology. But the development of complete analyses demands not only good luck and delicate technique but also critical semantic clarity and severity. Given the best tools, we shall solve major theoretical problems only if we understand quite fully what problem it is that we are trying to solve--and the history of science illustrates that this is not as elementary a matter as it sounds.(ABSTRACT TRUNCATED AT 250 WORDS)

  8. All Night Spectral Analysis of EEG Sleep in Young Adult and Middle-Aged Male Subjects

    NARCIS (Netherlands)

    Dijk, Derk Jan; Beersma, Domien G.M.; Hoofdakker, Rutger H. van den

    1989-01-01

    The sleep EEGs of 9 young adult males (age 20-28 years) and 8 middle-aged males (42-56 years) were analyzed by visual scoring and spectral analysis. In the middle-aged subjects power density in the delta, theta and sigma frequencies were attenuated as compared to the young subjects. In both age grou

  9. Ageing, Health and Life Satisfaction of the Oldest Old: An Analysis for Germany

    Science.gov (United States)

    Gwozdz, Wencke; Sousa-Poza, Alfonso

    2010-01-01

    This analysis uses data from the German Socio-Economic Panel and the Survey on Health, Ageing and Retirement in Europe to assess the effect of ageing and health on the life satisfaction of the oldest old (defined as 75 and older). We observe a U-shaped relationship between age and levels of life satisfaction for individuals aged between 16 and 65.…

  10. A Novel Linear Switched Reluctance Machine: Analysis and Experimental Verification

    Directory of Open Access Journals (Sweden)

    N. C. Lenin

    2010-01-01

    Full Text Available The important problems to be solved in Linear Switched Reluctance Machines (LSRMs are: (1 to design the shape and size of poles in stator and translator cores; (2 to optimize their geometrical configuration. A novel stator geometry for LSRMs that improved the force profile was presented in this study. In the new geometry, pole shoes were affixed on the stator poles. Static and dynamic characteristics for the proposed structure had been highlighted using Two Dimensional (2-D Finite Element Analyses (FEA. Motor performance for variable load conditions was discussed. The finite element analyses and the experimental results of this study proved that, LSRMs were one of the strong candidates for linear propulsion drives. Problem statement: To mitigate the force ripple without any loss in average force and force density. Approach: Design modifications in the magnetic structures. Results: 2-D finite element analysis was used to predict the performance of the studied structures. Conclusion/Recommendations: The proposed structure not only reduces the force ripple, also reduced the volume and mass. The future study is to make an attempt on vibration, thermal and stress analyses.

  11. Experimental and numerical analysis of automotive gearbox rattle noise

    Science.gov (United States)

    Kadmiri, Younes; Rigaud, Emmanuel; Perret-Liaudet, Joël; Vary, Laurence

    2012-06-01

    The aim of this work is to characterize the rattle noise of automotive gearboxes, resulting from impacts between toothed wheels of unselected gear ratios. These stereo-mechanical impacts are modeled by a coefficient of restitution which describes damping during the squeezing of the lubricant film for approaching surfaces, and the elastic deformation of impacting bodies. The dynamic response of the loose gear first depends on the design parameters and the engine operating conditions. The unknown parameters are the drag torque and the coefficient of restitution. They are identified experimentally through implementation of two optical encoders in an actual automotive gearbox and the operation of a specific test bench which replicates the automotive power train. Models of the different drag torque sources are validated from analysis of the free damped response of the driveline. The coefficient of restitution and its probability density function are measured from experiments under stationary operating conditions. A nonlinear model is built. The dynamic response of the loose gear depends on the dimensionless backlash, the coefficient of restitution and a dimensionless parameter proposed to describe the rattle excitation level. Experiments under controlled excitation are performed to validate the assumptions, to confirm the ability of the parameter proposed to describe the rattle noise threshold, and to characterize the dynamic response. The nonlinear model predictions are fitted with the drag torque and coefficient of restitution previously identified. They are compared with measurements to demonstrate the ability of the model to predict gear rattle for any loose gear, any gearbox and any operating condition.

  12. Uniaxial Fatigue of HDPE-100 Pipe. Experimental Analysis

    Directory of Open Access Journals (Sweden)

    A. Aid

    2014-04-01

    Full Text Available In this paper, an experimental analysis for determining the fatigue strength of PE-100, one of the most used High Density Polyethylene (HDPE materials for pipes, under cyclic axial loadings is presented. HDPE is a thermoplastic material used for piping systems, such as natural gas distribution systems, sewer systems and cold water systems, which provides a good alternative to metals such as cast iron or carbon steel. One of the causes for failures of HDPE pipes is fatigue which is the result of pipes being subjected to cyclic loading, such as internal pressure, weight loads or external loadings on buried pipes, which generate stress in different directions: circumferential, longitudinal and radial. HDPE pipes are fabricated using an extrusion process, which generates anisotropic properties. By testing in the Laboratory a series of identical specimens obtained directly from PE-100 HDPE pipes in longitudinal directions, the relationships between amplitude stress and number of cycles (S-N curve test frequency 2 Hz and stress ratio R = 0.0 are established.

  13. Analysis of experimental studies on gully erosion: a global review

    Science.gov (United States)

    Castillo, Carlos; Gómez, Jose A.

    2015-04-01

    Research on gully erosion has increased significantly in the last decades. Despite the growing interest on the topic, relevant knowledge gaps still remain a challenge for gully erosion researchers (Poesen, 2011). Moreover, many of these studies are mainly descriptive, with little quantitative data allowing a comparison of the severity of the processes among different environments and conditions. The aim of this communication is to analyse the available experimental data in gully erosion literature involving quantitative information from the Web of Science datasets. Our objective is to investigate relevant trends of this type of erosion on the world scale. We have evaluated the role of gully erosion in the overall soil losses as well as the magnitude of the morphological variables. Also, we analysed the characteristics of image-based and field surveys regarding the technique employed, duration and data collection frequency. In this communication, we intend to provide insights on the evolution of gully erosion research up to the present moment in order to gain perspectives on the design of future efforts in the topic. References Poesen, J. 2011. Challenges in gully erosion research. Landform Analysis, Vol. 17: 5-9.

  14. Removal of polycyclic aromatic hydrocarbons from aged-contaminated soil using cyclodextrins: experimental study

    Energy Technology Data Exchange (ETDEWEB)

    Christophe Viglianti; Khalil Hanna; Christine de Brauer; Patrick Germain [Laboratoire d' Analyse Environnementale des Procedes et des Systemes Industriels - INSA de Lyon, Villeurbanne (France)

    2006-04-15

    The removal of polycyclic aromatic hydrocarbons (PAHs) from soil using water as flushing agent is relatively ineffective due to their low aqueous solubility. However, addition of cyclodextrin (CD) in washing solutions has been shown to increase the removal efficiency several times. Herein are investigated the effectiveness of cyclodextrin to remove PAH occurring in industrially aged-contaminated soil. {beta}-Cyclodextrin (BCD), hydroxypropyl-{beta}-cyclodextrin (HPCD) and methyl-{beta}-cyclodextrin (MCD) solutions were used for soil flushing in column test to evaluate some influent parameters that can significantly increase the removal efficiency. The process parameters chosen were CD concentration, ratio of washing solution volume to soil weight, and temperature of washing solution. These parameters were found to have a significant and almost linear effect on PAH removal from the contaminated soil, except the temperature where no significant enhancement in PAH extraction was observed for temperature range from 5 to 35{sup o}C. The PAHs extraction enhancement factor compared to water was about 200.

  15. Lap Shear and Impact Testing of Ochre and Beeswax in Experimental Middle Stone Age Compound Adhesives.

    Directory of Open Access Journals (Sweden)

    P R B Kozowyk

    Full Text Available The production of compound adhesives using disparate ingredients is seen as some of the best evidence of advanced cognition outside of the use of symbolism. Previous field and laboratory testing of adhesives has shown the complexities involved in creating an effective Middle Stone Age glue using Acacia gum. However, it is currently unclear how efficient different adhesive recipes are, how much specific ingredients influence their performance, and how difficult it may have been for those ingredients to be combined to maximum effect. We conducted a series of laboratory-based lap shear and impact tests, following modern adhesion testing standards, to determine the efficacy of compound adhesives, with particular regard to the ingredient ratios. We tested rosin (colophony and gum adhesives, containing additives of beeswax and ochre in varying ratios. During both lap shear and impact tests compound rosin adhesives performed better than single component rosin adhesives, and pure acacia gum was the strongest. The large difference in performance between each base adhesive and the significant changes in performance that occur due to relatively small changes in ingredient ratios lend further support to the notion that high levels of skill and knowledge were required to consistently produce the most effective adhesives.

  16. Lap Shear and Impact Testing of Ochre and Beeswax in Experimental Middle Stone Age Compound Adhesives.

    Science.gov (United States)

    Kozowyk, P R B; Langejans, G H J; Poulis, J A

    2016-01-01

    The production of compound adhesives using disparate ingredients is seen as some of the best evidence of advanced cognition outside of the use of symbolism. Previous field and laboratory testing of adhesives has shown the complexities involved in creating an effective Middle Stone Age glue using Acacia gum. However, it is currently unclear how efficient different adhesive recipes are, how much specific ingredients influence their performance, and how difficult it may have been for those ingredients to be combined to maximum effect. We conducted a series of laboratory-based lap shear and impact tests, following modern adhesion testing standards, to determine the efficacy of compound adhesives, with particular regard to the ingredient ratios. We tested rosin (colophony) and gum adhesives, containing additives of beeswax and ochre in varying ratios. During both lap shear and impact tests compound rosin adhesives performed better than single component rosin adhesives, and pure acacia gum was the strongest. The large difference in performance between each base adhesive and the significant changes in performance that occur due to relatively small changes in ingredient ratios lend further support to the notion that high levels of skill and knowledge were required to consistently produce the most effective adhesives.

  17. The analysis of aging skin based on multiphoton microscopy

    Science.gov (United States)

    Wu, Shulian; Li, Hui; Zhang, Xiaoman; Li, Zhifang; Xu, Shufei

    2010-11-01

    Aging is a very important issue not only in dermatology, but also in cosmetic science. Cutaneous aging involves both chronological and photoaging aging process. The chronological aging is induced with the passage of time. And the photoaging skin is the extrinsic aging caused by sun exposure. The aim of this study is to use multiphoton microscopy (MPM) in vivo to assess intrinsic-age-related and photo-age-related difference. The changes of dermal collagen are measured in quantitively. The algorithm that we used automatically produced the transversal dermal map from MPM. Others, the texture of dermis are analyzed by Fourier transform and Gray Level Co-occurrence Matrix. And the object extraction in textured images is proposed based on the method in object edge extraction, and the aim of it is to detect the object hidden in the skin texture in difference aging skin. The result demonstrates that the approach is effective in detecting the object in epidermis and dermis textured image in different aging skin. It could help to further understand the aging mechanism.

  18. Acid Aging Effects on Surfaces of PTFE Gaskets Investigated by Thermal Analysis

    Directory of Open Access Journals (Sweden)

    C. Fragassa

    2016-12-01

    Full Text Available This paper investigates the effect of a prolonged acid attack on the surface of PTFE by Thermogravimetric Analysis (TGA and Differential Scanning Calorimetry (DSC. PTFE is very non-reactive, partly because of the strength of carbon–fluorine bonds and for its high crystallinity, and, as a consequence, it is often used in containers and pipework with reactive and corrosive chemicals. The PTFE under analysis is commercialized by two alternative producers in form of Teflon tapes. These tapes are adopted, as gaskets, in process plants where tires moulds are cleaned by acid solutions inside a multistage ultrasonic process. In this case, PTFE shows, in a relatively short operation time, inexplicably phenomena of surface degradation, which could be related, in general terms, to an acid attack. But, even considering the combined effect of ultrasonic waves, temperature, humidity and acid attack, the PTFE properties of resistance nominally exclude the risk of the extreme erosion phenomena as observed. The present experimental research aim at investigating this contradiction. A possible explanation could be related to the presence in the cleaning solution of unexpected fluorides, able to produce fluorinating agents and, thus, degrade carbon-fluorine bonds. Considering more the 300 chemical elements a tire compound consists in, it is really complex to preserve the original chemical composition of the cleaning solution. In this research PTFE samples have been treated with different mixtures of acids with the aim at investigating the different aging effects. The thermal analysis has permitted the experimental characterization of PTFE surface properties after acid attack, providing evidence of the degradation phenomena. In particular, the different acid treatments adopted for accelerating the aging of gaskets have highlighted the different behaviour of the PTFE matrix, but also differences between manufacturers.

  19. A comparative analysis of root dentin transparency with known age

    Directory of Open Access Journals (Sweden)

    Anita Singhal

    2010-01-01

    Full Text Available Objective: To correlate dimensions of root transparency and age, and to assess whether transparency is reliable for age estimation of unknown. Materials and Methods: 50 freshly extracted single rooted permanent teeth from 50 different individuals (27 males and 23 females were collected and their ground sections of 400 ΅m were stained with 1% methylene blue. The area of the translucent zone was measured by superimposing a transparent graph paper on the ground section under stereomicroscope. The length of the translucency was measured by using digital vernier caliper. Results: A strong positive correlation between age and translucency of dentin was noted. The length rather than the area of the translucent zone correlated more with age. Conclusion: Translucency of the root dentin increases with age and it can be used as a reliable parameter for the age estimation.

  20. Experimental stress analysis for materials and structures stress analysis models for developing design methodologies

    CERN Document Server

    Freddi, Alessandro; Cristofolini, Luca

    2015-01-01

    This book summarizes the main methods of experimental stress analysis and examines their application to various states of stress of major technical interest, highlighting aspects not always covered in the classic literature. It is explained how experimental stress analysis assists in the verification and completion of analytical and numerical models, the development of phenomenological theories, the measurement and control of system parameters under operating conditions, and identification of causes of failure or malfunction. Cases addressed include measurement of the state of stress in models, measurement of actual loads on structures, verification of stress states in circumstances of complex numerical modeling, assessment of stress-related material damage, and reliability analysis of artifacts (e.g. prostheses) that interact with biological systems. The book will serve graduate students and professionals as a valuable tool for finding solutions when analytical solutions do not exist.

  1. Study of age-related changes in postural control during quiet standing through Linear Discriminant Analysis

    Directory of Open Access Journals (Sweden)

    Andrade Adriano O

    2009-11-01

    Full Text Available Abstract Background The human body adopts a number of strategies to maintain an upright position. The analysis of the human balance allows for the understanding and identification of such strategies. The displacement of the centre of pressure (COP is a measure that has been successfully employed in studies regarding the postural control. Most of these investigations are related to the analysis of individuals suffering from neuromuscular disorders. Recent studies have shown that the elderly population is growing very fast in many countries all over the world, and therefore, researches that try to understand changes in this group are required. In this context, this study proposes the analysis of the postural control, measured by the displacement of the COP, in groups of young and elderly adults. Methods In total 59 subjects participated of this study. They were divided into seven groups according to their age. The displacement of the COP was collected for each subject standing on a force plate. Two experimental conditions, of 30 seconds each, were investigated: opened eyes and closed eyes. Traditional and recent digital signal processing tools were employed for feature computation from the displacement of the COP. Statistical analyses were carried out in order to identify significant differences between the features computed from the distinct groups that could allow for their discrimination. Results Our results showed that Linear Discrimination Analysis (LDA, which is one of the most popular feature extraction and classifier design techniques, could be successfully employed as a linear transformation, based on the linear combination of standard features for COP analysis, capable of estimating a unique feature, so-called LDA-value, from which it was possible to discriminate the investigated groups and show a high correlation between this feature and age. Conclusion These results show that the analysis of features computed from the displacement of

  2. Experimental Analysis of Stochastic Resonance in a Duffing System

    Institute of Scientific and Technical Information of China (English)

    WANG Fu-Zhong; CHEN Wei-Shi; QIN Guang-Rong; GUO De-Yong; LIU Jun-Ling

    2003-01-01

    An experimental circuit is used to study the stochastic resonance (SR) phenomena in a Duffing system. The characteristics ofSR are investigated from various aspects by varying all the possible parameters. The deviations between the experimental results and the adiabatic theory are presented.

  3. Experimental Methods for the Analysis of Optimization Algorithms

    DEFF Research Database (Denmark)

    of solution quality, runtime and other measures; and the third part collects advanced methods from experimental design for configuring and tuning algorithms on a specific class of instances with the goal of using the least amount of experimentation. The contributor list includes leading scientists...

  4. Experimental analysis of microscale rain cells and their dynamic evolution

    Science.gov (United States)

    Enjamio, C.; Vilar, E.; RedañO, A.; FontáN, F. P.; Ndzi, D.

    2005-06-01

    This paper presents a detailed space-time analysis of rainfall rate using two dense networks of rain gauges covering two microscale areas of some 100 km2 each and located in two distinct climatic areas in the United Kingdom and Spain. The study has been carried out with the main objective of addressing dynamic fade mitigation techniques and scatter interference problems in terrestrial and satellite communication systems. The two databases, using a total of 49 and 23 rain gauges, respectively, are described, and the continuous interpolated field used for the subsequent analyses is explained in detail. The suitability of the networks in terms of density, correlation distance, and fractal dimension are briefly addressed. A to-scale comparison grid of the networks is also given. It has been found that when the maximum intensity reached during a rain event surpasses a certain threshold, different for each of the two areas, rainfall rates exhibit a spatial structure in the form of closed contours of thresholds referred to as cells. In statistical terms, the most probable diameter found is about 3.5 km, and distributions are presented. They are similar for the two sites but not so for the maxima reached inside the cells. Using cross-correlation techniques, displacement and velocities are analyzed in detail. Cells "zigzag" around a dominant trend because of the global cloud movements (driven by winds at heights of about 700 hPa). Local topography strongly affects local behavior. Analytical approximations to the experimental statistical distributions and selected histograms of the results are presented.

  5. Towards experimental validation of an analysis framework for morphing radiators

    Science.gov (United States)

    Bertagne, Christopher L.; Erickson, Lisa R.; Sheth, Rubik B.; Whitcomb, John D.; Hartl, Darren J.

    2016-04-01

    Thermal control is an important aspect of spacecraft design, particularly in the case of crewed vehicles, which must maintain a precise internal temperature at all times in spite of sometimes drastic variations in the external thermal environment and internal heat loads. The successes of the Space Shuttle and International Space Station programs have shown that this can be accomplished in Low Earth Orbit (LEO), however, crewed spacecraft traveling beyond LEO are expected to encounter more challenging thermal conditions with significant variations in both the heat rejection requirements and environment temperature. Such missions will require radiator systems with high turndown ratios, defined as the ratio between the maximum and minimum heat rejection rates achievable by the radiator system. Current radiators are only able to achieve turndown ratios of 3:1, far less than the 12:1 turndown ratio which is expected to be required on future missions. An innovative radiator concept, known as a morphing radiator, uses the temperature-induced shape change of shape memory alloy (SMA) materials to achieve a turndown ratio of at least 12:1. Predicting the thermal and structural behavior of SMA-based morphing radiators is challenging due to the presence of two-way thermomechanical coupling that has not been widely considered in the literature. Previous work has demonstrated the application of a technique known as a partitioned analysis procedure which can be used to simulate the behavior of morphing radiators. This work describes ongoing efforts to evaluate the physical accuracy of this approach by conducting validation studies. A detailed finite element model of a morphing radiator is developed and executed using the framework. Preliminary results show close agreement between the experimental data and model predictions, giving additional confidence in the partitioned approach.

  6. Case-control analysis of paternal age and trisomic anomalies

    DEFF Research Database (Denmark)

    De Souza, E; Morris, David Jackson; Garne, Ester

    2010-01-01

    To determine whether older paternal age increases the risk of fathering a pregnancy with Patau (trisomy 13), Edwards (trisomy 18), Klinefelter (XXY) or XYY syndrome.......To determine whether older paternal age increases the risk of fathering a pregnancy with Patau (trisomy 13), Edwards (trisomy 18), Klinefelter (XXY) or XYY syndrome....

  7. A roadmap for the genetic analysis of renal aging

    NARCIS (Netherlands)

    Noordmans, Gerda A.; van Goor, Harry; Hillebrands, Jan-Luuk; Korstanje, Ron

    2015-01-01

    Several studies show evidence for the genetic basis of renal disease, which renders some individuals more prone than others to accelerated renal aging. Studying the genetics of renal aging can help us to identify genes involved in this process and to unravel the underlying pathways. First, this opin

  8. Age Analysis of Public Library Collections. Final Report.

    Science.gov (United States)

    Wallace, Danny P.; And Others

    The use of information regarding the ages of library items is a standard component of many approaches to weeding library collections, and has a long history in the literature of collection management. Current and past approaches to using aging information to make weeding decisions make use of very arbitrary decision criteria. This study examined…

  9. Analysis on age structure of Zoysia japonica(Poaceae) population

    Institute of Scientific and Technical Information of China (English)

    WANGYan; DAIBao-qing; LIANGYong-jun; MALian-ju

    2003-01-01

    The age-structure of natural population of Zoysia japonica in Xiuyan County of Liaoning Province was studied by generational method.The results showed that the highest tiller age class was three,but 1st age class tillers held dominant position with proportions over 95% in each month during the growing seasons.The 2nd age class and 2rd age class tillers were minority in the population.So Z.japonica population was an expanding population.The zero age class buds on the rhizomes were dominantin buds age structures.The proportion of buds to tillers on quantity in each month was about 30% to 40% and reached the highest at the end of September.The increasing of buds proportion before dormancy guaranteed the quantity of tillers in the next spring.The biomass of 1st age class tillers changed with time.The biomass kept increasing from April to July and reached the highest at the end of July and then decreased.

  10. AGEING POPULATION: COMPARATIVE ANALYSIS AMONG EUROPEAN UNION STATES

    Directory of Open Access Journals (Sweden)

    Laura DIACONU (MAXIM

    2015-03-01

    Full Text Available The aging population is a global phenomenon, which has affected almost all the EU states. The consequences are very important since it affects the socio-economic environment usually on the long run. Some of them could consist in increasing the public expenditure on pensions, social security and health services, which will raise the overall burden on the working population. Sometimes, a significant reduction of the labour force will even diminish the growth rate of an economy. Considering these aspects, the present paper intends to analyse the demographic situation from the EU states, the factors that have generated it and to identify the possible future trends. To determine the evolution of the ageing population phenomenon, we have analysed some demographic indicators included in various statistical reports and databases, such as the fertility rate, the median age, the percentage of population over a certain age and the age dependency ratio.

  11. Etching zircon age standards for fission-track analysis

    Energy Technology Data Exchange (ETDEWEB)

    Garver, J.I. E-mail: garverj@union.edu

    2003-02-01

    Nineteen laboratories that routinely measure fission-track ages in zircon were surveyed as to their principal methodology used for track revelation using chemical attack and counting procedures. The survey results show the following: (a) researchers in most labs count fission tracks with a optical microscope using at a total magnification between 1250x and 1600x ({approx}80%) with about an equal number using either a dry or oil objective (b) the majority of laboratories etch zircon with a KOH:NaOH eutectic heated in an oven between temperatures of 210 deg. C and 230 deg. C; (c) ag standards in zircon analysis do not have uniformly accepted etch times. Etching times for the widely used 28 Ma Fish Canyon Tuff (FCT) (4-60 h) and the lesser-used 16 Ma Buluk Tuff (13-55 h) vary significantly from lab to lab. Between {approx}220 deg. C and 230 deg. C, the principal range fo etching times for the FCT is between 20 and 30 h, and the mode for the Buluk Tuff is between 30 and 55 h. Three or fewer labs report etching times for the Tardee Rhyolite (22-40 h), the Bishop Tuff (10-46 h), and the Mt. Dromedary Banite (5-24 h). Variation in etching times may result in a bias in U-content which affects counting statistics. If etching is successful, strict criteria must be followed to ensure that the analyst only counts well-etched grains and that all tracks are successfully identified.

  12. Age-related change in executive function: developmental trends and a latent variable analysis.

    Science.gov (United States)

    Huizinga, Mariëtte; Dolan, Conor V; van der Molen, Maurits W

    2006-01-01

    This study examined the developmental trajectories of three frequently postulated executive function (EF) components, Working Memory, Shifting, and Inhibition of responses, and their relation to performance on standard, but complex, neuropsychological EF tasks, the Wisconsin Card Sorting Task (WCST), and the Tower of London (ToL). Participants in four age groups (7-, 11-, 15-, and 21-year olds) carried out nine basic experimental tasks (three tasks for each EF), the WCST, and the ToL. Analyses were done in two steps: (1) analyses of (co)variance to examine developmental trends in individual EF tasks while correcting for basic processing speed, (2) confirmatory factor analysis to extract latent variables from the nine basic EF tasks, and to explain variance in the performance on WCST and ToL, using these latent variables. Analyses of (co)variance revealed a continuation of EF development into adolescence. Confirmatory factor analysis yielded two common factors: Working Memory and Shifting. However, the variables assumed to tap Inhibition proved unrelated. At a latent level, again correcting for basic processing speed, the development of Shifting was seen to continue into adolescence, while Working Memory continued to develop into young-adulthood. Regression analyses revealed that Working Memory contributed most strongly to WCST performance in all age groups. These results suggest that EF component processes develop at different rates, and that it is important to recognize both the unity and diversity of EF component processes in studying the development of EF.

  13. Analysis of frailty and survival from late middle age in the Beijing Longitudinal Study of Aging

    Directory of Open Access Journals (Sweden)

    Tang Zhe

    2011-04-01

    Full Text Available Abstract Background Frailty in individuals can be operationalized as the accumulation of health deficits, for which several trends have been observed in Western countries. Less is known about deficit accumulation in China, the country with the world's largest number of older adults. Methods This study analyzed data from the Beijing Longitudinal Study of Aging, to evaluate the relationship between age and deficit accumulation in men and women and to evaluate the impact of frailty on mortality. Community dwelling people aged 55+ years at baseline (n = 3275 were followed every two to three years between 1992 and 2000, during which time 36% died. A Frailty Index was constructed using 35 deficits, drawn from a range of health problems, including symptoms, disabilities, disease, and psychological difficulties. Results Most deficits increased the eight-year risk of death and were more lethal in men than in women, although women had a higher mean level of frailty (Frailty Index = 0.11 ± 0.10 for men, 0.14 ± 0.12 for women. The Frailty Index increased exponentially with age, with a similar rate in men and women (0.038 vs. 0.039; r > 0.949, P Conclusions A Frailty Index employed in a Chinese sample, showed properties comparable with Western data, but deficit accumulation appeared to be more lethal than in the West.

  14. Nonlinear Topological Component Analysis: Application to Age-Invariant Face Recognition.

    Science.gov (United States)

    Bouchaffra, Djamel

    2015-07-01

    We introduce a novel formalism that performs dimensionality reduction and captures topological features (such as the shape of the observed data) to conduct pattern classification. This mission is achieved by: 1) reducing the dimension of the observed variables through a kernelized radial basis function technique and expressing the latent variables probability distribution in terms of the observed variables; 2) disclosing the data manifold as a 3-D polyhedron via the α -shape constructor and extracting topological features; and 3) classifying a data set using a mixture of multinomial distributions. We have applied our methodology to the problem of age-invariant face recognition. Experimental results obtained demonstrate the efficiency of the proposed methodology named nonlinear topological component analysis when compared with some state-of-the-art approaches.

  15. A meta-analysis on experimental infections with porcine circovirus type 2 (PCV2).

    Science.gov (United States)

    Tomás, Anna; Fernandes, Lana T; Valero, Oliver; Segalés, Joaquim

    2008-12-10

    A meta-analysis was performed with the aim to identify factors with a relevant influence on the expression of clinical postweaning multisystemic wasting syndrome (PMWS) under experimental conditions. Data from 44 studies were included in the analysis. Several variables were studied: number of pigs in the experiment, intake of colostrum, serological status against porcine circovirus type 2 (PCV2), strain of PCV2 used for inoculation, the route and dose of inoculation, and use of potential triggering factors (such as co-infections, vaccinations, or immunomodulator products). Multiple correspondence analysis and log-linear regression methods were used to establish the relationships between the studied variables and the number of PCV2 infected pigs that developed PMWS. Based on the results of the meta-analysis, the most successful animal experiment aimed to develop PMWS should include: (1) colostrum-deprived pigs, (2) age of inoculation below 3 weeks, (3) high doses of PCV2 inoculum, (4) PCV2 strain from genotype 1, and (5) co-infection with another swine pathogen as a triggering factor.

  16. Analysis on Menarche Age of Chinese Reproductive Women

    Institute of Scientific and Technical Information of China (English)

    武俊青; 高尔生; 张子豹

    2000-01-01

    Objectives To analyze the age of menarche of Chinese reproductive women and some related factors.Material & Methods The data used in this paper was collected through “National Demography and Reproductive Health Survey” of China in 1997.Results The menarche age declined successively and dramatically, from 16. 45 years of the women born in 194 7~1949 to 13. 86 of those born in 1980~1982, decreasing by 0. 65 years per decade.Conclusions The results revealed that some factors such as residence, year of birth,nationality, education level and living region had effects on the menarche age.

  17. Analysis on Menarche Age of Chinese Reproductive Women

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Objectives To analyze the age of menarche of Chinese reproductive women and some related factors. Material & Methods The data used in this paper was collected through "National Demography and Reproductive Health Survey" of China in 1997. Results The menarche age declined successively and dramatically, from 16. 45 years of the women born in 1947~1949 to 13. 86 of those born in 1980~1982, decreasing by 0. 65 years per decade. Conclusions The results revealed that some factors such as residence, year of birth, nationality, education level and living region had effects on the menarche age.

  18. Theoretical and experimental analysis of the induction generators; Analise teorica e experimental do gerador de inducao

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Marcel; Martins Neto, Luciano; Calixto, Wesley Pacheco; Gontijo, Andre Luiz; Alves, Aylton Jose [Universidade Federal de Uberlandia (LMEE/FEELT/UFU), MG (Brazil). Fac. de Engenharia Eletrica. Lab. de Maquinas Eletricas Especiais], E-mails: marcel@mestrado.ufu.br, lmn@ufu.br, wpcalixto@ieee.org, aja@cefetgo.br

    2009-10-15

    Due to its lower costs, robustness, reduced maintenance and easy operation, the induction generator shows to be an economic alternative in small power generator systems. This work presents the initial phase of pertinent studies about the employment of the induction generator directly connected to the electrical power grid in a pilot project to be implemented at the Santa Luzia SHP. A project that aims to raise relevant operational aspects and to evidence some advantages about the employment of the induction generator in small power generator systems. This phase comprises the experimentation of an induction generator directly connected to the power grid in a laboratorial scale, plus a computational modeling which represents the same. This computational modeling takes into account loads variations which are being supplied by the generator, unbalance between phases and magnetic saturation effects, such as harmonic distortions in the generated currents. From the experimental model collected data, a theoretical-experimental confrontation of the computational modeling is made, where quantitative and qualitative analyses about the operational characteristics of the machine are made. The results of this work will head the operation and supervision of the SHP induction machine. (author)

  19. Comparative Analysis of Old-Age Mortality Estimations in Africa

    Science.gov (United States)

    Bendavid, Eran; Seligman, Benjamin; Kubo, Jessica

    2011-01-01

    Background Survival to old ages is increasing in many African countries. While demographic tools for estimating mortality up to age 60 have improved greatly, mortality patterns above age 60 rely on models based on little or no demographic data. These estimates are important for social planning and demographic projections. We provide direct estimations of older-age mortality using survey data. Methods Since 2005, nationally representative household surveys in ten sub-Saharan countries record counts of living and recently deceased household members: Burkina Faso, Côte d'Ivoire, Ethiopia, Namibia, Nigeria, Swaziland, Tanzania, Uganda, Zambia, and Zimbabwe. After accounting for age heaping using multiple imputation, we use this information to estimate probability of death in 5-year intervals (5qx). We then compare our 5qx estimates to those provided by the World Health Organization (WHO) and the United Nations Population Division (UNPD) to estimate the differences in mortality estimates, especially among individuals older than 60 years old. Findings We obtained information on 505,827 individuals (18.4% over age 60, 1.64% deceased). WHO and UNPD mortality models match our estimates closely up to age 60 (mean difference in probability of death -1.1%). However, mortality probabilities above age 60 are lower using our estimations than either WHO or UNPD. The mean difference between our sample and the WHO is 5.9% (95% CI 3.8–7.9%) and between our sample is UNPD is 13.5% (95% CI 11.6–15.5%). Regardless of the comparator, the difference in mortality estimations rises monotonically above age 60. Interpretation Mortality estimations above age 60 in ten African countries exhibit large variations depending on the method of estimation. The observed patterns suggest the possibility that survival in some African countries among adults older than age 60 is better than previously thought. Improving the quality and coverage of vital information in developing countries will become

  20. Comparative analysis of old-age mortality estimations in Africa.

    Directory of Open Access Journals (Sweden)

    Eran Bendavid

    Full Text Available BACKGROUND: Survival to old ages is increasing in many African countries. While demographic tools for estimating mortality up to age 60 have improved greatly, mortality patterns above age 60 rely on models based on little or no demographic data. These estimates are important for social planning and demographic projections. We provide direct estimations of older-age mortality using survey data. METHODS: Since 2005, nationally representative household surveys in ten sub-Saharan countries record counts of living and recently deceased household members: Burkina Faso, Côte d'Ivoire, Ethiopia, Namibia, Nigeria, Swaziland, Tanzania, Uganda, Zambia, and Zimbabwe. After accounting for age heaping using multiple imputation, we use this information to estimate probability of death in 5-year intervals ((5q(x. We then compare our (5q(x estimates to those provided by the World Health Organization (WHO and the United Nations Population Division (UNPD to estimate the differences in mortality estimates, especially among individuals older than 60 years old. FINDINGS: We obtained information on 505,827 individuals (18.4% over age 60, 1.64% deceased. WHO and UNPD mortality models match our estimates closely up to age 60 (mean difference in probability of death -1.1%. However, mortality probabilities above age 60 are lower using our estimations than either WHO or UNPD. The mean difference between our sample and the WHO is 5.9% (95% CI 3.8-7.9% and between our sample is UNPD is 13.5% (95% CI 11.6-15.5%. Regardless of the comparator, the difference in mortality estimations rises monotonically above age 60. INTERPRETATION: Mortality estimations above age 60 in ten African countries exhibit large variations depending on the method of estimation. The observed patterns suggest the possibility that survival in some African countries among adults older than age 60 is better than previously thought. Improving the quality and coverage of vital information in developing

  1. Survey of the quality of experimental design, statistical analysis and reporting of research using animals.

    Directory of Open Access Journals (Sweden)

    Carol Kilkenny

    Full Text Available For scientific, ethical and economic reasons, experiments involving animals should be appropriately designed, correctly analysed and transparently reported. This increases the scientific validity of the results, and maximises the knowledge gained from each experiment. A minimum amount of relevant information must be included in scientific publications to ensure that the methods and results of a study can be reviewed, analysed and repeated. Omitting essential information can raise scientific and ethical concerns. We report the findings of a systematic survey of reporting, experimental design and statistical analysis in published biomedical research using laboratory animals. Medline and EMBASE were searched for studies reporting research on live rats, mice and non-human primates carried out in UK and US publicly funded research establishments. Detailed information was collected from 271 publications, about the objective or hypothesis of the study, the number, sex, age and/or weight of animals used, and experimental and statistical methods. Only 59% of the studies stated the hypothesis or objective of the study and the number and characteristics of the animals used. Appropriate and efficient experimental design is a critical component of high-quality science. Most of the papers surveyed did not use randomisation (87% or blinding (86%, to reduce bias in animal selection and outcome assessment. Only 70% of the publications that used statistical methods described their methods and presented the results with a measure of error or variability. This survey has identified a number of issues that need to be addressed in order to improve experimental design and reporting in publications describing research using animals. Scientific publication is a powerful and important source of information; the authors of scientific publications therefore have a responsibility to describe their methods and results comprehensively, accurately and transparently, and peer

  2. Survey of the quality of experimental design, statistical analysis and reporting of research using animals.

    Science.gov (United States)

    Kilkenny, Carol; Parsons, Nick; Kadyszewski, Ed; Festing, Michael F W; Cuthill, Innes C; Fry, Derek; Hutton, Jane; Altman, Douglas G

    2009-11-30

    For scientific, ethical and economic reasons, experiments involving animals should be appropriately designed, correctly analysed and transparently reported. This increases the scientific validity of the results, and maximises the knowledge gained from each experiment. A minimum amount of relevant information must be included in scientific publications to ensure that the methods and results of a study can be reviewed, analysed and repeated. Omitting essential information can raise scientific and ethical concerns. We report the findings of a systematic survey of reporting, experimental design and statistical analysis in published biomedical research using laboratory animals. Medline and EMBASE were searched for studies reporting research on live rats, mice and non-human primates carried out in UK and US publicly funded research establishments. Detailed information was collected from 271 publications, about the objective or hypothesis of the study, the number, sex, age and/or weight of animals used, and experimental and statistical methods. Only 59% of the studies stated the hypothesis or objective of the study and the number and characteristics of the animals used. Appropriate and efficient experimental design is a critical component of high-quality science. Most of the papers surveyed did not use randomisation (87%) or blinding (86%), to reduce bias in animal selection and outcome assessment. Only 70% of the publications that used statistical methods described their methods and presented the results with a measure of error or variability. This survey has identified a number of issues that need to be addressed in order to improve experimental design and reporting in publications describing research using animals. Scientific publication is a powerful and important source of information; the authors of scientific publications therefore have a responsibility to describe their methods and results comprehensively, accurately and transparently, and peer reviewers and

  3. Experimental increase in availability of a PAH complex organic contamination from an aged contaminated soil: consequences on biodegradation.

    Science.gov (United States)

    Cébron, Aurélie; Faure, Pierre; Lorgeoux, Catherine; Ouvrard, Stéphanie; Leyval, Corinne

    2013-06-01

    Although high PAH content and detection of PAH-degraders, the PAH biodegradation is limited in aged-contaminated soils due to low PAH availability (i.e., 1%). Here, we tried to experimentally increase the soil PAH availability by keeping both soil properties and contamination composition. Organic extract was first removed and then re-incorporated in the raw soil as fresh contaminants. Though drastic, this procedure only allowed a 6-time increase in the PAH availability suggesting that the organic constituents more than ageing were responsible for low availability. In the re-contaminated soil, the mineralization rate was twice more important, the proportion of 5-6 cycles PAH was higher indicating a preferential degradation of lower molecular weight PAH. The extraction treatment induced bacterial and fungal community structures modifications, Pseudomonas and Fusarium solani species were favoured, and the relative quantity of fungi increased. In re-contaminated soil the percentage of PAH-dioxygenase gene increased, with 10 times more Gram negative representatives.

  4. [Visual pattern analysis and reasoning: Ravens' Coloured Progressive Matrices in old-age and very-old-age adults].

    Science.gov (United States)

    Diesfeldt, H F; Vink, M T

    1989-12-06

    Sixty-five non-demented elderly adults, born between 1895 and 1918 (mean age +/- sd: 80.0 +/- 5.4) were tested with Raven's Coloured Progressive Matrices (CPM). Subjects were recruited from homes for the aged and were rated by the staff as free from any symptoms of dementia or other psychiatric disease. Mean number of years of education was 8.2 (range 5 to 18). CPM scores ranged from 9 to 35 with mean +/- sd of 25.9 +/- 5.9. Subjects who had received more formal education performed better on the CPM (Pearson's r: 0.49). When education was controlled for in the analysis, the correlation between age and performance was attenuated and did not reach statistical significance (Pearson's r: -0.24). Test results appeared to be specific for generations, regardless of age. Mean performance in this sample was significantly higher than less recently published norms suggest. Analysis of item content revealed that the CPM consists of three main types of problems: two of a predominantly visuospatial type (12 items of simple continuous pattern-completion and 15 concrete items showing progressive changes in one or two directions) and 9 items of an abstract reasoning type. The concrete visuospatial items appear very useful in the assessment of visuoperceptive dysfunction, as for example in visual apperceptive agnosia. The abstract matrices were very difficult for most of our elderly subjects, so that these items cannot be used to detect deviations from normal old age.

  5. Analysis of Ageing Effect on Li-Polymer Batteries

    Directory of Open Access Journals (Sweden)

    Simone Barcellona

    2015-01-01

    Full Text Available Lithium-ion batteries are a key technology for current and future energy storage in mobile and stationary application. In particular, they play an important role in the electrification of mobility and therefore the battery lifetime prediction is a fundamental aspect for successful market introduction. Numerous studies developed ageing models capable of predicting battery life span. Most of the previous works compared the effect of the ageing factors to a battery’s cycle life. These cycles are identical, which is not the case for electric vehicles applications. Indeed, most of the available information is based on results from laboratory testing, under very controlled environments, and using ageing protocols, which may not correctly reflect the actual utilization. For this reason, it is important to link the effect of duty cycles with the ageing of the batteries. This paper proposes a simple method to investigate the effect of the duty cycle on the batteries lifetime through tests performed on different cells for different kinds of cycle. In this way, a generic complex cycle can be seen as a composition of elemental cycles by means of Rainflow procedures. Consequently, the ageing due to any cycle can be estimated starting from the knowledge of simpler cycles.

  6. Analysis of Ageing Effect on Li-Polymer Batteries.

    Science.gov (United States)

    Barcellona, Simone; Brenna, Morris; Foiadelli, Federica; Longo, Michela; Piegari, Luigi

    2015-01-01

    Lithium-ion batteries are a key technology for current and future energy storage in mobile and stationary application. In particular, they play an important role in the electrification of mobility and therefore the battery lifetime prediction is a fundamental aspect for successful market introduction. Numerous studies developed ageing models capable of predicting battery life span. Most of the previous works compared the effect of the ageing factors to a battery's cycle life. These cycles are identical, which is not the case for electric vehicles applications. Indeed, most of the available information is based on results from laboratory testing, under very controlled environments, and using ageing protocols, which may not correctly reflect the actual utilization. For this reason, it is important to link the effect of duty cycles with the ageing of the batteries. This paper proposes a simple method to investigate the effect of the duty cycle on the batteries lifetime through tests performed on different cells for different kinds of cycle. In this way, a generic complex cycle can be seen as a composition of elemental cycles by means of Rainflow procedures. Consequently, the ageing due to any cycle can be estimated starting from the knowledge of simpler cycles.

  7. An Analysis on the Spatial Distribution of Population Aging Pressure in China

    Institute of Scientific and Technical Information of China (English)

    YangWangzhou; Dong Suocheng; Wu Youde; Luo Renbo

    2012-01-01

    Based on comprehensive analysis of the impact of population aging to social and economic development, a comprehensive evaluation system including 18 indexes was constructed for evaluating regional pressure of population aging on social and economic development. Using statistics data of 31 regions in Chi- na from 2004 to 2008, the pressure of population aging on social and economic development, was comprehensively evaluated by using the factor analysis method. The spatial distribution of popu- lation aging in China was also analyzed. This study is to provide scientific basis for government to make strategies of coping with population aging according to regional pressure of population ag- ing on social and economic development in China.

  8. CONCENTRATION OF CIRCULATING IMMUNE COMPLEXES IN EXPERIMENTAL GENERALIZED INFLAMMATORY PROCESS IN ANIMALS OF DIFFERENT AGE UNDER ACTION OF IMMUNOMODULATORS

    Directory of Open Access Journals (Sweden)

    Kovalenko T.I.

    2015-05-01

    Full Text Available Under physiological conditions a formation and a presence of the CEC in liquids is one of the manifestations of the immune response to receipt of antigens and an important factor, which provides immunity. Circulating immune complexes act as agents involved in the regulation of immune response and maintaining communication between the immune system and other regulatory systems of the body and direction to his defense. The intensity of the formation of the CEC may vary under the influence of infectious antigens and immune preparations. Material and methods. Material for the experiment were white male rats 3 months of age ("young" weighing 100 -140gr. (n = 40 and 22-month ("old" weighing 200 -240 g. (n = 40. And the first (n=10 and second (n=10 groups of rats served as controls. Third (n=15 and fourth (n=15 group of animals was injected intraperitoneal daily agar culture of Pseudomonas aeruginosa № 27835 ATCC (injected with 1.5 ml suspension of bacteria, which contained 109 CFU/ml. Fifth (n=15 and sixth (n=15 groups of animals were injected intraperitoneally daily agar culture of Escherichia coli number 25592, ATCC (injected with 1.5 ml of bacteria suspension which contain 109 CFU/ml. Control animals were taken from the experiment by decapitation 3rd day – n=20. Control and infected animals were taken from the experiment by decapitation at 3rd day - n=27, 5th day – n=27 and 7th day – n=26. In the second phase of the experiment Ia (n = 6 and IIa (n = 6 were the control group of rats following administration of the experimental composite preparation consisting amino acids, nucleotides, enzymes, vitamins (MF. In two age groups of animals with inflammation induced by E. coli suspension treated with MF 20 mсl 3- month rats (IIIa group n = 6 and 40 mсl 22-month rats (IVa group n = 6. Ib (n = 6 and IIb (n = 6 were the control group of rats after the injection of comparison, containing mannitol and natural antioxidant betakaroten (PO. In two age

  9. Experimental analysis of pressurised humidification tower for humid air gas turbine cycles. Part A: Experimental campaign

    Energy Technology Data Exchange (ETDEWEB)

    Pedemonte, A.A. [Thermochemical Power Group (TPG), Dipartimento di Macchine, Sistemi Energetici e Trasporti (DIMSET), Universita di Genova, 16145 Genova (Italy); Traverso, A. [Thermochemical Power Group (TPG), Dipartimento di Macchine, Sistemi Energetici e Trasporti (DIMSET), Universita di Genova, 16145 Genova (Italy)], E-mail: alberto.traverso@unige.it; Massardo, A.F. [Thermochemical Power Group (TPG), Dipartimento di Macchine, Sistemi Energetici e Trasporti (DIMSET), Universita di Genova, 16145 Genova (Italy)

    2008-10-15

    One of the most interesting methods of water introduction in a gas turbine circuit is represented by the humid air turbine cycle (HAT). In the HAT cycle, the humidification can be provided by a pressurised saturator (i.e. humidification tower or saturation tower), this solution being known to offer several attractive features. This part A is focused on an experimental study of a pressurised humidification tower, with structured packing inside. After a description of the test rig employed to carry out the measuring campaign, the results relating to the thermodynamic process are presented and discussed. The experimental campaign was carried out over 162 working points, covering a relatively wide range of possible operating conditions. Details about measured data are provided in the appendix. It is shown that the saturator's behaviour, in terms of air outlet humidity and temperature, is primarily driven by, in decreasing order of relevance, the inlet water temperature, the inlet water over inlet dry air mass flow ratio and the inlet air temperature. Finally, the exit relative humidity is shown to be consistently over 100%, which may be explained partially by measurement accuracy and droplet entrainment, and partially by the non-ideal behaviour of air-steam mixtures close to saturation.

  10. Experimental Analysis and Model Validation of an Opaque Ventilated Facade

    DEFF Research Database (Denmark)

    López, F. Peci; Jensen, Rasmus Lund; Heiselberg, Per

    2012-01-01

    Natural ventilation is a convenient way of reducing energy consumption in buildings. In this study an experimental module of an opaque ventilated façade (OVF) was built and tested for assessing its potential of supplying free ventilation and air preheating for the building. A numerical model was ...

  11. Experimental Disclosure and Its Moderators: A Meta-Analysis

    Science.gov (United States)

    Frattaroli, Joanne

    2006-01-01

    Disclosing information, thoughts, and feelings about personal and meaningful topics (experimental disclosure) is purported to have various health and psychological consequences (e.g., J.W. Pennebaker, 1993). Although the results of 2 small meta-analyses (P. G. Frisina, J. C. Borod, & S. J. Lepore, 2004; J. M. Smyth, 1998) suggest that experimental…

  12. Meta-Analysis at Middle Age: A Personal History

    Science.gov (United States)

    Glass, Gene V.

    2015-01-01

    The 40-year history of meta-analysis is traced from the vantage point of one of its originators. Research syntheses leading to the first examples of meta-analysis are identified. Early meta-analyses of the literature on psychotherapy outcomes and school class size are recounted. The influence on the development of meta-analysis of several…

  13. The "Journal of the Experimental Analysis of Behavior" at Zero, Fifty, and One Hundred

    Science.gov (United States)

    Catania, A. Charles

    2008-01-01

    The experimental content areas represented in "JEAB" in its first volume (1958) and fifty 50 years later in Volume 87 are in many ways similar with regard to research on schedules of reinforcement, research with human subjects, and several other topics. Experimental analysis has not been displaced by quantitative analysis. Much less research on…

  14. Estimation of age in forensic medicine using multivariate approach to image analysis

    DEFF Research Database (Denmark)

    Kucheryavskiy, Sergey V.; Belyaev, Ivan; Fominykh, Sergey

    2009-01-01

    A new method for victims' age estimation, based on the image processing and analysis of remains bones structure, is proposed. Digital images of lumbar vertebras cuts were used as a major information source. The age related properties were extracted from the images using classic texture analysis a...

  15. Inclusion of Aging in Rehabilitation Counseling Journals 2000-2012: A Content Analysis

    Science.gov (United States)

    Kettaneh, Amani A.; Kinyanjui, Benson; Slevin, John R.; Slevin, Barbara; Harley, Debra A.

    2015-01-01

    Purpose: To conduct a content analysis of the rehabilitation counseling literature to identify articles published on aging. Method: To determine the number of articles that were published on aging in rehabilitation counseling journals, a content analysis of articles from 2000 through 2012 was performed. For purposes of this review, only…

  16. Age, the psychological contract, and job attitudes : a meta-analysis

    NARCIS (Netherlands)

    Bal, P. Matthijs; de Lange, Annet H.; Jansen, Paul G. W.; van der Velde, Mandy E. G.

    2010-01-01

    Age, the psychological contract, and job attitudes: a meta-analysis P.M. Bal, A H. De Lange, P.G.W Jansen Er M.E G Van der Velde, Gedrag en Organisatie, volume 23, March 2010, nr 1, pp 44-72. The meta-analysis investigated the relations between age and psychological contracts It was expected that ag

  17. Case-control analysis of paternal age and trisomic anomalies

    NARCIS (Netherlands)

    De Souza, E.; Morris, Joan K.

    2010-01-01

    Objectives To determine whether older paternal age increases the risk of fathering a pregnancy with Patau (trisomy 13), Edwards (trisomy 18), Klinefelter (XXY) or XYY syndrome. Design Case-control: cases with each of these syndromes were matched to four controls with Down syndrome from within the sa

  18. A Bayesian Analysis of the Ages of Four Open Clusters

    CERN Document Server

    Jeffery, Elizabeth J; van Dyk, David A; Stenning, David C; Robinson, Elliot; Stein, Nathan; Jefferys, W H

    2016-01-01

    In this paper we apply a Bayesian technique to determine the best fit of stellar evolution models to find the main sequence turn off age and other cluster parameters of four intermediate-age open clusters: NGC 2360, NGC 2477, NGC 2660, and NGC 3960. Our algorithm utilizes a Markov chain Monte Carlo technique to fit these various parameters, objectively finding the best-fit isochrone for each cluster. The result is a high-precision isochrone fit. We compare these results with the those of traditional "by-eye" isochrone fitting methods. By applying this Bayesian technique to NGC 2360, NGC 2477, NGC 2660, and NGC 3960, we determine the ages of these clusters to be 1.35 +/- 0.05, 1.02 +/- 0.02, 1.64 +/- 0.04, and 0.860 +/- 0.04 Gyr, respectively. The results of this paper continue our effort to determine cluster ages to higher precision than that offered by these traditional methods of isochrone fitting.

  19. Birefringence of cellotape: Jones representation and experimental analysis

    Energy Technology Data Exchange (ETDEWEB)

    Belendez, Augusto; Frances, Jorge; Neipp, Cristian [Departamento de Fisica, Ingenieria de Sistemas y Teoria de la Senal, Universidad de Alicante, Apartado 99, E-03080 Alicante (Spain); Fernandez, Elena [Departamento de Optica, FarmacologIa y Anatomia, Universidad de Alicante, Apartado 99, E-03080 Alicante (Spain)], E-mail: a.belendez@ua.es

    2010-05-15

    In this paper, we analyse a simple experiment to study the effects of polarized light. A simple optical system composed of a polarizer, a retarder (cellotape) and an analyser is used to study the effect on the polarization state of the light which impinges on the setup. The optical system is characterized by means of a Jones matrix, and a simple procedure based on Jones vectors is used to obtain an expression for the intensity after the light passes through the optical system. The light intensity is measured by a photodetector and the expression obtained theoretically is experimentally validated. By fitting the experimental intensity data, the value of the retardation introduced by the retarder can also be obtained.

  20. An Experimental and Numerical Analysis of Puff Hydrodynamics

    Directory of Open Access Journals (Sweden)

    Saidi MS

    2014-12-01

    Full Text Available The permeability of a tobacco rod in a cigarette increases as it converts into char and ash in the coal. The hot coal introduces a significant resistance to the air flow when air passes through. Through a series of experiments, the cigarette burn line and burn rate, the centerline temperature, and the pressure drop were measured for continuous puffing conditions. The gas viscosity was calculated from the temperature distribution inside the cigarette and applying Sutherland's law. Then, the experimental setup was mathematically modeled from a commercially available CFD (Computational Fluid Dynamics code and, by matching the numerical and experimental results, the changes in coal and filter permeability during puffing were estimated. The numerical simulation successfully reproduced the results of experiments on the air flow through the coal, ventilation holes and paper wrapper.

  1. Floor Heating with Displacement Ventilation: An Experimental and Numerical Analysis

    DEFF Research Database (Denmark)

    Causone, Francesco; Olesen, Bjarne W.; Corgnati, S.P.

    2010-01-01

    The effect of floor heating combined with displacement ventilation (DV) on thermal indoor environments and indoor air quality (IAQ) was studied by means of CFD. The numerical model was validated with experimental data. A typical office room was simulated, and one of the occupants was considered...... to be the contaminant source. The CFD model reliably simulated air velocities and temperatures. Also ventilation effectiveness values were coherent with experimental data. The model made it possible to understand the effect oldie downdraft from a cold window on the dissemination of contaminant in the room. Although...... ventilation effectiveness at seated breathing height was always higher than one, it was not possible to visualize a defined contaminant stratification in the room. Only when the windows were not assumed to be cold, a clearly stratified flow pattern could be detected. The numerical model was then used...

  2. Analysis of experimental data on correlations between cumulative particles

    Energy Technology Data Exchange (ETDEWEB)

    Vlasov, A.V.; Doroshkevich, E.A.; Leksin, G.A. [Institute of Theoretical and Experimental Physics, Moscow (Russian Federation)] [and others

    1995-04-01

    Experimental data on correlations between cumulative particles are analyzed. A space-time and energy-transfer pattern of hadron-nucleus interaction based on both correlation data and data on the inclusive spectra of cumulative particles is considered. A new variable that is convenient for describing the production of cumulative particles is proposed using the concept of symmetry between the one-particle and multiparticle distributions. 32 refs., 9 figs., 1 tab.

  3. Experimental methods for the analysis of optimization algorithms

    CERN Document Server

    Bartz-Beielstein, Thomas; Paquete, Luis; Preuss, Mike

    2010-01-01

    In operations research and computer science it is common practice to evaluate the performance of optimization algorithms on the basis of computational results, and the experimental approach should follow accepted principles that guarantee the reliability and reproducibility of results. However, computational experiments differ from those in other sciences, and the last decade has seen considerable methodological research devoted to understanding the particular features of such experiments and assessing the related statistical methods. This book consists of methodological contributions on diffe

  4. Dynamics of a high speed impeller - Analysis and experimental verification

    Science.gov (United States)

    Straub, F. K.; Ngo, H.; Silverthorn, L. J.; Ruopsa, J. A.

    1993-04-01

    Centrifugal compressors are used on numerous aircraft as an efficient and lightweight source of air. The impeller is the key compressor component, both from an aerodynamic and structural dynamics point of view. The present paper investigates the structural dynamics of the blades of a particular impeller, using analytical and experimental methods. Correlation of results show good agreement. The analytical model is then used for design studies to improve the fatigue life of the impeller blades.

  5. Numerical and experimental analysis of vertical spray control patternators

    Directory of Open Access Journals (Sweden)

    F. Sarghini

    2013-09-01

    Full Text Available The experimental vertical spray control walls have the purpose of picking up the liquid delivered by trained sprayer for providing the liquid distribution profile in height. Theoretically this should correspond to the ideal profile, which consists in a uniform distribution on the vegetation. If the profile is different from the ideal, a parameter setup is required on the sprayer. Nonetheless, some problems are hidden in the aforementioned statements: i no wall measures exactly the distribution profile (i.e. the flow through the sections in the vertical plane, parallel to the direction of advancement of the sprayer. Compared to real profile, sensitive errors are introduced: the evaporation of the drops, the deviation of the air flows caused by the sensors panel themselves; by the possibility that the drops bounce on the wall panels, also due to the current of air that can push the liquid veil laterally or upwards, Moreover, everything varies depending on the geometry of the sensors, air velocity, air humidity; ii no one knows what exactly is the optimal distribution profile. It is often considered as optimal a profile that reflects the amount of leaf area subtended by each section absorber: however, it is evident that the path of the droplets changes according to the sprayer typology (eg. radial-flow or horizontal flows. In this work a combined numerical-experimental approach is adopted, in order to assess some of the aforementioned issues: numerical data obtained by using computational fluid dynamics models are compared and validated with experimental data, in order to assess the reliability of numerical simulations in configurations which are difficult to analyze using an experimental setup.

  6. Comparative experimental analysis of composite pulses in 14N NQR.

    Science.gov (United States)

    Mikhaltsevitch, V T; Rudakov, T N; Flexman, J H; Hayes, P A; Chisholm, W P

    2004-01-01

    Experimental results of comparing composite pulses in nitrogen-14 NQR, that are analogous to common 90 degrees RF pulses in powder, are presented. All tested pulses have been taken from publications in journals. Comparative diagrams of the measurement results for induction signals and echo signals are presented. The results of the measurements demonstrate that the best outcomes are achieved when the composite pulse (45)0(95)180(164)0 is used.

  7. [Experimental analysis of finishing lines in ceramometal restorations].

    Science.gov (United States)

    Gascón, F; Gil, J A; Fons, A; Badal, R

    1990-11-01

    The preparation is the first step of any tooth reconstruction. The biological integration of the protesis is depending on the marginal adaptation (finish line of the preparation), occlusal adaptation (occlusal reduction), longevity of the restoration (retention and luting) and esthetics. The effect the two finish line of the preparation is studied using experimental design. In porcelain-fused-to-metal the finish line of the preparation in chanfer is superior at the beveled shoulder, because proportioning better marginal adaptation.

  8. Experimental modal analysis of lithium-ion pouch cells

    OpenAIRE

    2015-01-01

    If future electric and hybrid electric vehicle batteries are to be designed such that the impact of vibration induced resonance is minimized, engineers tasked with the design of the vehicle’s energy storage system must have a rigorous understanding of key system attributes such as the natural frequencies of the cell, the level of damping present and the mode shapes induced within the battery under mechanical load. This paper describes the underpinning theory and experimental method employed w...

  9. Experimental facility for analysis of biomass combustion characteristics

    Directory of Open Access Journals (Sweden)

    Miljković Biljana M.

    2015-01-01

    Full Text Available The objective of the present article is to present an experimental facility which was designed and built at the Faculty of Technical Sciences in order to study the combustion of different sorts of biomass and municipal solid waste. Despite its apparent simplicity, direct combustion is a complex process from a technological point of view. Conventional combustion equipment is not designed for burning agricultural residues. Devices for agricultural waste combustion are still in the development phase, which means that adequate design solution is presently not available at the world market. In order to construct a boiler and achieve optimal combustion conditions, it is necessary to develop a mathematical model for biomass combustion. Experimental facility can be used for the collection of data necessary for detailed modelling of real grate combustor of solid biomass fuels. Due to the complexity of the grate combustion process, its mathematical models and simulation software tools must be developed and verified using experimental data. This work highlights the properties required for the laboratory facility designed for the examination of biomass combustion and discusses design and operational issues.

  10. Humidification tower for humid air gas turbine cycles: Experimental analysis

    Energy Technology Data Exchange (ETDEWEB)

    Traverso, A. [DIMSET (TPG), University of Genoa, Via Montallegro 1, 16145 Genoa (Italy)

    2010-02-15

    In the HAT (humid air turbine) cycle, the humidification of compressed air can be provided by a pressurised saturator (i.e. humidification tower or saturation tower), this solution being known to offer several attractive features. This work is focused on an experimental study of a pressurised humidification tower, with structured packing. After a description of the test rig employed to carry out the measuring campaign, the results relating to the thermodynamic process are presented and discussed. The experimental campaign was carried out over 162 working points, covering a relatively wide range of possible operating conditions. It is shown that the saturator behaviour, in terms of air outlet humidity and temperature, is primarily driven by, in decreasing order of relevance, the inlet water temperature, the inlet water over inlet dry air mass flow ratio and the inlet air temperature. The exit relative humidity is consistently over 100%, which may be explained partially by measurement accuracy and droplet entrainment, and partially by the non-ideal behaviour of air-steam mixtures close to saturation. Experimental results have been successfully correlated using a set of new non-dimensional groups: such a correlation is able to capture the air outlet temperature with a standard deviation {sigma} = 2.8 K. (author)

  11. Experimental and modeling analysis of the NOxOUT process

    Energy Technology Data Exchange (ETDEWEB)

    Rota, R.; Antos, D.; Zanoelo, E.V.; Morbidelli, M. [Politecnico di Milano, Milano (Italy). Dipartimento di Chimica Fisica Applicata/CIIRCO

    2002-01-01

    The selective non-catalytic reduction of nitric oxide with urea has been investigated experimentally in a temperature range from 950 to 1450 K using a laboratory reactor that approximates well stirred conditions. From the experimental results it has been possible not only to deduce some generate trends of interest in the NOxOUT process, but also to validate a detailed kinetic mechanism. In particular, the experiments showed that the NOxOUT process is effective in a narrow temperature window. The effect of increasing the ratio of nitrogen in the reducing agent and in NO is to increase the efficiency of abatement, while that of increasing O{sub 2} concentration depends on the temperature considered. Moreover, the effect of increasing the CO/NO ratio up to one is not very pronounced. The detailed kinetic mechanism developed has been validated by comparison with several experimental findings, thus providing an effective tool for process simulation in a wide range of operating conditions.

  12. Data analysis with R in an experimental physics environment

    CERN Document Server

    Pfeiffer, Andreas

    2013-01-01

    A software package has been developed to bridge the R analysis model with the conceptual analysis environment typical of radiation physics experiments. The new package has been used in the context of a project for the validation of simulation models, where it has demonstrated its capability to satisfy typical requirements pertinent to the problem domain.

  13. The Analysis of Vocational Aptitude Changing with Age

    OpenAIRE

    Wada, Masayuki; OGAWA, Kazuo; Akagi, Fumio; Osaki, Hirokazu; Kikuchi, Susumu

    1980-01-01

    The assumption that vocational aptitude changed with age and with the kind of occupation was examined from the tendency of the fitted curve for the score of the aptitude test. 9 vocational aptitudes were measured by the general vocational aptitude test by Japan Labor Ministry. Subjects were 382 male workers (design engineers, turners, welders, can manufacturing workers, and crane operators) of from 20 to 59 years old, and 348 male and female students (junior high school, vocational school, an...

  14. Analysis of aging in lager brewing yeast during serial repitching.

    Science.gov (United States)

    Bühligen, Franziska; Lindner, Patrick; Fetzer, Ingo; Stahl, Frank; Scheper, Thomas; Harms, Hauke; Müller, Susann

    2014-10-10

    Serial repitching of brewing yeast inoculates is an important economic factor in the brewing industry, as their propagation is time and resource intensive. Here, we investigated whether replicative aging and/or the population distribution status changed during serial repitching in three different breweries with the same brewing yeast strain but different abiotic backgrounds and repitching regimes with varying numbers of reuses. Next to bud scar numbers the DNA content of the Saccharomyces pastorianus HEBRU cells was analyzed. Gene expression patterns were investigated using low-density microarrays with genes for aging, stress, storage compound metabolism and cell cycle. Two breweries showed a stable rejuvenation rate during serial repitching. In a third brewery the fraction of virgin cells varied, which could be explained with differing wort aeration rates. Furthermore, the number of bud scars per cell and cell size correlated in all 3 breweries throughout all runs. Transcriptome analyses revealed that from the 6th run on, mainly for the cells positive gene expression could be seen, for example up-regulation of trehalose and glycogen metabolism genes. Additionally, the cells' settling in the cone was dependent on cell size, with the lowest and the uppermost cone layers showing the highest amount of dead cells. In general, cells do not progressively age during extended serial repitching.

  15. Influencing factors analysis of spontaneous knee joint osteoarthritis among middle aged and old aged pople in Xi'an

    Institute of Scientific and Technical Information of China (English)

    WANG Wei; WANG Kun-zheng; DANG Xiao-qian; BAI Chuan-yi; WANG Chun-sheng; SHI ZHi-bin; MA Shu-qiang

    2007-01-01

    Objective:To explore the prevalence rate of knee joint osteoarthritis and its pathogenetic features among the middle-aged and old aged people in the urban and rural area of Xi'an. Methods: From May to October 2005, 1 538 Han nationality above 40 years in Xi'an were investigated according to stratified and cluster random sampling. The same questionnaire was delivered to subjects who had been given normotopia and lateral position radiographic examination in both knees. Excluded from etiological arthritis, some subjects with clinical symptoms and a radiographic grade (beyond Kellgren & Lawrence grade Ⅱ ) were finally diagnosed as spontaneous knee joint osteoarthritis. All analyses were performed with SPSS 13.0 and t test, U test. Single factor analysis and multiple logistic regression analysis were used to analyze dates. Results: The total prevalence of spontaneous knee joint osteoarthritis was 12. 1% with 2.5% and 2.1% for right and left knees, respectively. The prevalence of knee joint osteoarthritis in women was 2.5 times of that in men (17.2% vs 6.8%, P=0.000). the osteophyte prevalence in women was 2.3 times of that in men (26.5% vs 11.4%, P=0.000). The prevalence of knee joint osteoarthritis and osteophyte increased with the growth of age. So did the symptomatic knee, except for the age group of 56-60 years and 66-70 years. The prevalence of symptomatic knee joint for urban area was significantly higher than that for rural area (56. 3% vs 45.3%, P=0.003). In women, the prevalence of knee joint osteoarthritis increased significantly with the increasing of body mass index, which had not been observed in men. Female and obesity are the risk factors for osteoarthritis, but bean and its products and meat could prevent the osteoarthritis. Conclusion: Old age, female and obesity serve as risk factors for knee joint osteoarthritis.

  16. Transparent meta-analysis: does aging spare prospective memory with focal vs. non-focal cues?

    Directory of Open Access Journals (Sweden)

    Bob Uttl

    Full Text Available BACKGROUND: Prospective memory (ProM is the ability to become aware of a previously-formed plan at the right time and place. For over twenty years, researchers have been debating whether prospective memory declines with aging or whether it is spared by aging and, most recently, whether aging spares prospective memory with focal vs. non-focal cues. Two recent meta-analyses examining these claims did not include all relevant studies and ignored prevalent ceiling effects, age confounds, and did not distinguish between prospective memory subdomains (e.g., ProM proper, vigilance, habitual ProM (see Uttl, 2008, PLoS ONE. The present meta-analysis focuses on the following questions: Does prospective memory decline with aging? Does prospective memory with focal vs. non-focal cues decline with aging? Does the size of age-related declines with focal vs. non-focal cues vary across ProM subdomains? And are age-related declines in ProM smaller than age-related declines in retrospective memory? METHODS AND FINDINGS: A meta-analysis of event-cued ProM using data visualization and modeling, robust count methods, and conventional meta-analysis techniques revealed that first, the size of age-related declines in ProM with both focal and non-focal cues are large. Second, age-related declines in ProM with focal cues are larger in ProM proper and smaller in vigilance. Third, age-related declines in ProM proper with focal cues are as large as age-related declines in recall measures of retrospective memory. CONCLUSIONS: The results are consistent with Craik's (1983 proposal that age-related declines on ProM tasks are generally large, support the distinction between ProM proper vs. vigilance, and directly contradict widespread claims that ProM, with or without focal cues, is spared by aging.

  17. Experimental Analysis of Bisbenzocyclobutene Bonded Capacitive Micromachined Ultrasonic Transducers

    OpenAIRE

    2016-01-01

    Experimental measurement results of a 1.75 mm × 1.75 mm footprint area Capacitive Micromachined Ultrasonic Transducer (CMUT) planar array fabricated using a bisbenzocyclobutene (BCB)-based adhesive wafer bonding technique has been presented. The array consists of 40 × 40 square diaphragm CMUT cells with a cavity thickness of 900 nm and supported by 10 µm wide dielectric spacers patterned on a thin layer of BCB. A 150 µm wide one µm thick gold strip has been used as the contact pad for gold wi...

  18. The ergonomics analysis of work: a case study in a experimental farm.

    Science.gov (United States)

    de Lourdes Santiago Luz, Maria; Lemos, Syntia

    2012-01-01

    This work presents the initial steps of ergonomic analysis of industrial activities, which are being held in the premises of an Agricultural Experimental farm belonging to an institution of higher education. The methods employed in the initial step was confined to desk research, its purpose was to know the demographic profile and understand organizational structure followed by systematic observations in workplaces using semi-structured interviews and a questionnaire of perception to operators. The presentation of the results will provide a summary of the analysis of activity sectors visited, understanding the biomechanical efforts entered (posture and strength), as well as the evaluation according to the perception of officials to respect the constraints, ambience and suggestions. It was noted that 90% of employees surveyed feel some kind of discomfort. It also highlights the age factor of this questionnaire, in which the majority (90%) is above 40 years old, and this fact confirms and reinforces the appearance or accumulation of injuries among the employers. At this stage there was no intention to deploy improvements, but create assumptions and guide future intervention actions that can be performed.

  19. Multivariate Analysis of High Through-Put Adhesively Bonded Single Lap Joints: Experimental and Workflow Protocols

    Science.gov (United States)

    2016-06-01

    ARL-TR-7696 ● JUNE 2016 US Army Research Laboratory Multivariate Analysis of High Through- Put Adhesively Bonded Single Lap...TR-7696 ● JUNE 2016 US Army Research Laboratory Multivariate Analysis of High Through- Put Adhesively Bonded Single Lap Joints: Experimental...SUBTITLE Multivariate Analysis of High Through- Put Adhesively Bonded Single Lap Joints: Experimental and Workflow Protocols 5a. CONTRACT NUMBER 5b

  20. Analysis of malaria parasite phenotypes using experimental genetic crosses of Plasmodium falciparum

    OpenAIRE

    Ranford-Cartwright, Lisa C; Mwangi, Jonathan M.

    2012-01-01

    We review the principles of linkage analysis of experimental genetic crosses and their application to Plasmodium falciparum. Three experimental genetic crosses have been performed using the human malaria parasite P. falciparum. Linkage analysis of the progeny of these crosses has been used to identify parasite genes important in phenotypes such as drug resistance, parasite growth and virulence, and transmission to mosquitoes. The construction and analysis of genetic maps has been used to char...

  1. Laser Brazing with Beam Scanning: Experimental and Simulative Analysis

    Science.gov (United States)

    Heitmanek, M.; Dobler, M.; Graudenz, M.; Perret, W.; Göbel, G.; Schmidt, M.; Beyer, E.

    Laser beam brazing with copper based filler wire is a widely established technology for joining zinc-coated steel plates in the body-shop. Successful applications are the divided tailgate or the zero-gap joint, which represents the joint between the side panel and the roof-top of the body-in-white. These joints are in direct view to the customer, and therefore have to fulfil highest optical quality requirements. For this reason a stable and efficient laser brazing process is essential. In this paper the current results on quality improvement due to one dimensional laser beam deflections in feed direction are presented. Additionally to the experimental results a transient three-dimensional simulation model for the laser beam brazing process is taken into account. With this model the influence of scanning parameters on filler wire temperature and melt pool characteristics is analyzed. The theoretical predictions are in good accordance with the experimental results. They show that the beam scanning approach is a very promising method to increase process stability and seam quality.

  2. Experimental analysis of a flat heat pipe working against gravity

    Energy Technology Data Exchange (ETDEWEB)

    Esarte, J.; Domiguez, M. [Universidad Publica de Navarra (Spain). Dept. of Mechanical Engineering

    2003-09-01

    Thermoelectric refrigeration always presents a heat flux addressing problem (constriction resistance) and it is a subject that has extensively been studied and analysed [closed form equation for thermal constriction/spreading resistances with variable resistances boundary conditions, IEPS Conference, 1994]. In previous works [Issues of the heat dissipation coming from a big surface through a much smaller one, 20th International Conference on Thermoelectrics, Beijing-China, 2001], a device (flat heat pipe) capable of addressing the heat flux has been theoretically and experimentally developed to reduce the so called constriction resistance (the lower the constriction resistance the higher the thermoelectric module performance). This work presents the experimental results of the constriction resistance for different prototypes of flat heat pipe and investigates if they are in agreement with the theoretical predictions. It also shows the influence of certain parameters on the constriction resistance. The results have later been compared with those obtained for a flat plate in order to check whether or not the device improves the thermoelectric module performance. A brief description of the device operation is also given. (Author)

  3. Experimental Analysis of Podded Propulsor on Naval Vessel

    Directory of Open Access Journals (Sweden)

    M.P. Abdul Ghani

    2014-03-01

    Full Text Available This paper describes the effect of pod propulsor attachment to the existing Naval Vessel hull form which was designed for conventional propulsor in aspects of resistance and motion characteristics. These investigations were carried out on a 3.0 m model by experimental works in the towing tank 120m x 4m x 2.5m at the Marine Technology Centre (MTC, Universiti Teknologi Malaysia (UTM. The basis ship chosen for this study is Sealift class type MPCSS (Multi Purpose Command Support Ship. In this study, the design for the new pod propulsor is based on a proven design and scaled down to suit this type of hullform accordingly. This paper describes the resistance comparison between bare and podded hulls in calm water as well in waves. The seakeeping test for hull with and without pod in regular waves at service speed of 16.8 knots were carried out at wavelength to model length ratio, Lw/Lm between 0.2 and 1.2. The outcomes from this experimental works on hull with and without pod were compared.

  4. A retrospective mathematical analysis of controlled release design and experimentation.

    Science.gov (United States)

    Rothstein, Sam N; Kay, Jennifer E; Schopfer, Francisco J; Freeman, Bruce A; Little, Steven R

    2012-11-01

    The development and performance evaluation of new biodegradable polymer controlled release formulations relies on successful interpretation and evaluation of in vitro release data. However, depending upon the extent of empirical characterization, release data may be open to more than one qualitative interpretation. In this work, a predictive model for release from degradable polymer matrices was applied to a number of published release data in order to extend the characterization of release behavior. Where possible, the model was also used to interpolate and extrapolate upon collected released data to clarify the overall duration of release and also kinetics of release between widely spaced data points. In each case examined, mathematical predictions of release coincide well with experimental results, offering a more definitive description of each formulation's performance than was previously available. This information may prove particularly helpful in the design of future studies, such as when calculating proper dosing levels or determining experimental end points in order to more comprehensively evaluate a controlled release system's performance.

  5. Experimental modal analysis of lithium-ion pouch cells

    Science.gov (United States)

    Hooper, James Michael; Marco, James

    2015-07-01

    If future electric and hybrid electric vehicle batteries are to be designed such that the impact of vibration induced resonance is minimized, engineers tasked with the design of the vehicle's energy storage system must have a rigorous understanding of key system attributes such as the natural frequencies of the cell, the level of damping present and the mode shapes induced within the battery under mechanical load. This paper describes the underpinning theory and experimental method employed when using the impulse excitation technique to quantify the natural frequencies and mode shapes of a commercially available 25 Ah Nickel Manganese Cobalt Oxide (NMC) Laminate Pouch Cell. Experimental results are presented for fifteen cells at five different values of state of charge (SOC). The results indicate that irrespective of the energy content within the cell, the same four modes of vibration (torsion and bending) exist within a frequency range of 191 Hz-360 Hz. This is above the frequency range (0-150 Hz) typically associated with road-induced vibration. The results also indicate that the cell's natural frequencies of vibration and damping do not vary with changing values of SOC.

  6. Decreased pain sensitivity among people with schizophrenia: a meta-analysis of experimental pain induction studies.

    Science.gov (United States)

    Stubbs, Brendon; Thompson, Trevor; Acaster, Sarah; Vancampfort, Davy; Gaughran, Fiona; Correll, Christoph U

    2015-11-01

    Patients with schizophrenia report reduced pain sensitivity in clinical studies, but experimental studies are required to establish pain sensitivity as a potential endophenotype. We conducted a systematic review of electronic databases from database inception until April 15, 2015, including experimental studies investigating pain among patients with schizophrenia spectrum disorder vs healthy controls. A random-effect meta-analysis yielding Hedges' g ±95% confidence intervals (CIs) as the effect size (ES) measure was conducted. Primary outcome was a pooled composite of pain threshold and pain tolerance; secondary outcomes included these parameters individually, plus sensory threshold, physiological pain response, and pain intensity or unpleasantness. Across 17 studies, patients with schizophrenia spectrum disorder (n = 387; age, 30.7 ± 6.9 years; females, 31.9%; illness duration, 7.0 ± 5.7 years) were compared with controls (n = 483; age, 29.5 ± 7.4 years; females, 31.0%). Patients had elevated pain threshold/pain tolerance vs controls (ES = 0.583; 95% CI, 0.212-0.954; P = 0.002; studies = 15). Results were similar in antipsychotic-free individuals (ES = 0.599; 95% CI, 0.291-0.907; P pain tolerance (ES = 0.566; 95% CI, 0.235-0.897; P = 0.0001; studies = 6), sensory threshold (ES = 1.16; 95% CI, 0.505-1.727; P pain threshold (ES = 0.696; 95% CI, 0.407-0.986; P pain intensity/unpleasantness ratings (ES = 0.547; 95% CI, 0.146-0.949; P = 0.008). Findings were similarly significant in antipsychotic-free patients with schizophrenia (analysable parameters = 4) and antipsychotic-treated individuals (analysable parameters = 2). Finally, greater psychiatric symptoms moderated increased pain threshold, and younger patient age moderated increased pain tolerance. Decreased pain sensitivity seems to be an endophenotype of schizophrenia spectrum disorders. How this alteration links to other dimensions of schizophrenia and physical comorbidity-related help-seeking behaviour

  7. Experimental burn plot trial in the Kruger National Park: history, experimental design and suggestions for data analysis

    Directory of Open Access Journals (Sweden)

    R. Biggs

    2003-12-01

    Full Text Available The experimental burn plot (EBP trial initiated in 1954 is one of few ongoing long-termfire ecology research projects in Africa. The trial aims to assess the impacts of differentfire regimes in the Kruger National Park. Recent studies on the EBPs have raised questions as to the experimental design of the trial, and the appropriate model specificationwhen analysing data. Archival documentation reveals that the original design was modified on several occasions, related to changes in the park's fire policy. These modifications include the addition of extra plots, subdivision of plots and changes in treatmentsover time, and have resulted in a design which is only partially randomised. The representativity of the trial plots has been questioned on account of their relatively small size,the concentration of herbivores on especially the frequently burnt plots, and soil variation between plots. It is suggested that these factors be included as covariates inexplanatory models or that certain plots be excluded from data analysis based on resultsof independent studies of these factors. Suggestions are provided for the specificationof the experimental design when analysing data using Analysis of Variance. It is concluded that there is no practical alternative to treating the trial as a fully randomisedcomplete block design.

  8. Scanning electron microscopy analysis of experimental bone hacking trauma.

    Science.gov (United States)

    Alunni-Perret, Veronique; Muller-Bolla, Michèle; Laugier, Jean-Pierre; Lupi-Pégurier, Laurence; Bertrand, Marie-France; Staccini, Pascal; Bolla, Marc; Quatrehomme, Gérald

    2005-07-01

    The authors report on their macro- and microscopy study of bone lesions made by a sharp force instrument (a single blade knife), and a sharp-blunt instrument classified as a chopping weapon (a hatchet). The aim of this work was to attempt to identify the instrument by analyzing the general class characteristics of the cuts. Each weapon was used on human bones. The results indicate that macroscopic analysis is more problematic. The microscopic analysis assessed that characteristics examined were effective in distinguishing sharp from sharp-blunt injury to the bone. The microscope facilitates analysis unachievable with macroscopic methods, some three-dimensional characteristics not visible to the naked eye being clearly defined with its use. Emphasis has been placed on the value of SEM as an anthropologist's tool in bone lesion injuries.

  9. Computer-assisted analysis of cervical vertebral bone age using cephalometric radiographs in Brazilian subjects

    Directory of Open Access Journals (Sweden)

    Maria de Paula Caldas

    2010-03-01

    Full Text Available The aims of this study were to develop a computerized program for objectively evaluating skeletal maturation on cephalometric radiographs, and to apply the new method to Brazilian subjects. The samples were taken from the patient files of Oral Radiological Clinics from the North, Northeast, Midwest and South regions of the country. A total of 717 subjects aged 7.0 to 15.9 years who had lateral cephalometric radiographs and hand-wrist radiographs were selected. A cervical vertebral computerized analysis was created in the Radiocef Studio 2 computer software for digital cephalometric analysis, and cervical vertebral bone age was calculated using the formulas developed by Caldas et al.17 (2007. Hand-wrist bone age was evaluated by the TW3 method. Analysis of variance (ANOVA and the Tukey test were used to compare cervical vertebral bone age, hand-wrist bone age and chronological age (P < 0.05. No significant difference was found between cervical vertebral bone age and chronological age in all regions studied. When analyzing bone age, it was possible to observe a statistically significant difference between cervical vertebral bone age and hand-wrist bone age for female and male subjects in the North and Northeast regions, as well as for male subjects in the Midwest region. No significant difference was observed between bone age and chronological age in all regions except for male subjects in the North and female subjects in the Northeast. Using cervical vertebral bone age, it might be possible to evaluate skeletal maturation in an objective manner using cephalometric radiographs.

  10. Slotted wiDom: schedulability analysis and its experimental validation

    OpenAIRE

    Maryam, Vahabi; Andersson, Björn

    2011-01-01

    WiDom is a wireless prioritized medium access control protocol which offers a very large number of priority levels. Hence, it brings the potential to employ non-preemptive static-priority scheduling and schedulability analysis for a wireless channel assuming that the overhead of WiDom is modeled properly. One schedulability analysis for WiDom has already been proposed but recent research has created a new version of WiDom (we call it: Slotted WiDom) with lower overh...

  11. Experimental Analysis of Aerodynamic Aspects of Sport Utility Vehicle

    Directory of Open Access Journals (Sweden)

    DINESH Y DHANDE

    2013-07-01

    Full Text Available In an era fuel efficiency has become topic of discussion not only among the scholar researchers but also common men. As rapid and continuous increase in prizes of fuels consumers are going for most fuel efficient vehicles. By aerodynamic styling of vehicle one can not only improve the fuel efficiency but also ensure better stability and good handling characteristics of vehicles at higher speed especially on highways. The paper describes assessment of drag force (Fd and drag coefficient (Cd by conventional wind tunnel method. Theexperimental calculations were performed on subsonic wind tunnel having test section of 100cm x 30cm x 30 cm. Exact replica of model of sports utility vehicle (suv on reduced scale 1:32 is used to for experimentation to calculate Fd and Cd.

  12. Theoretical and experimental analysis of an optical driven servo system

    Science.gov (United States)

    Lu, F.; Wang, X. J.; Huang, J. H.; Liu, Y. F.

    2016-09-01

    An optical driven servo system model based on single-type PLZT ceramic is proposed in this paper. The control equation of the proposed servo system is derived based on the mathematical model of PLZT with coupled multi-physics fields. The parameters of photodeformation of the PLZT actuator during both the illumination phase and light off phase are identified through the static experiment. Then displacement response of optical driven servo system is numerically simulated based on the control equation presented in this paper. After that, the closed-loop control experiment of optical driven servo system based on PLZT single-type ceramic with a simple on-off method is carried out. The experimental results show that the optical driven servo system with simple on-off method can achieve the target displacement by applying UV light to the PLZT actuator. Furthermore, an improved on-off control strategy is proposed to decrease the undesirable fluctuation around the target displacement.

  13. Experimental Analysis of Pressure Fluctuations behind a Bottom Aerator

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Experimental observations show that the random process of two-phase flow beh ind an aerator is an ergodic process and its amplitude distribution is similar t o a normal distribution. The maximum pressure fluctuation is at the re-attachme n t point where the jet-trajectory flow over the aerator re-attaches to bottom o f the channel, and its amplitude is 2-3 times larger than when there is no aerato r. There is a dominant frequency of 1.24 Hz in the model, but the coherence in th e frequency domain is not obvious for other frequencies beside the dominant frequ ency. There is a large vortex at the re-attachment point behind the aerator but correlation among the measurement points is not obvious in the time domain.

  14. Experimental analysis of green roof substrate detention characteristics.

    Science.gov (United States)

    Yio, Marcus H N; Stovin, Virginia; Werdin, Jörg; Vesuviano, Gianni

    2013-01-01

    Green roofs may make an important contribution to urban stormwater management. Rainfall-runoff models are required to evaluate green roof responses to specific rainfall inputs. The roof's hydrological response is a function of its configuration, with the substrate - or growing media - providing both retention and detention of rainfall. The objective of the research described here is to quantify the detention effects due to green roof substrates, and to propose a suitable hydrological modelling approach. Laboratory results from experimental detention tests on green roof substrates are presented. It is shown that detention increases with substrate depth and as a result of increasing substrate organic content. Model structures based on reservoir routing are evaluated, and it is found that a one-parameter reservoir routing model coupled with a parameter that describes the delay to start of runoff best fits the observed data. Preliminary findings support the hypothesis that the reservoir routing parameter values can be defined from the substrate's physical characteristics.

  15. Experimental Bifurcation Analysis Using Control-Based Continuation

    DEFF Research Database (Denmark)

    Bureau, Emil; Starke, Jens

    requires the constitution of a non-invasive and locally stabilizing control scheme, which must be tuned without a-priori study of a model. We propose a sequence of experiments that allows to choose optimal control-gains, filter parameters and settings for a continuation method. This experimental tuning...... and unstable equilibria under variation of parameters. As a test case we demonstrate that it is possible to track the complete frequency response, including the unstable branches, for a harmonically forced impact oscillator with hardening spring nonlinearity, controlled by electromagnetic actuators. The method...... instability in terms of finite-time Lyapunov exponents. A software toolbox for the Matlab continuation platform COCO has been developed and will be made freely available. This toolbox implements functions necessary for interfacing a numerical continuation code with a real experiment, as well as provide means...

  16. Experimental vibration level analysis of a Francis turbine

    Science.gov (United States)

    Bucur, D. M.; Dunca, G.; Cǎlinoiu, C.

    2012-11-01

    In this study the vibration level of a Francis turbine is investigated by experimental work in site. Measurements are carried out for different power output values, in order to highlight the influence of the operation regimes on the turbine behavior. The study focuses on the turbine shaft to identify the mechanical vibration sources and on the draft tube in order to identify the hydraulic vibration sources. Analyzing the vibration results, recommendations regarding the operation of the turbine, at partial load close to minimum values, in the middle of the operating domain or close to maximum values of electric power, can be made in order to keep relatively low levels of vibration. Finally, conclusions are drawn in order to present the real sources of the vibrations.

  17. Mass spectrometry analysis of hepcidin peptides in experimental mouse models.

    Directory of Open Access Journals (Sweden)

    Harold Tjalsma

    Full Text Available The mouse is a valuable model for unravelling the role of hepcidin in iron homeostasis, however, such studies still report hepcidin mRNA levels as a surrogate marker for bioactive hepcidin in its pivotal function to block ferroportin-mediated iron transport. Here, we aimed to assess bioactive mouse Hepcidin-1 (Hep-1 and its paralogue Hepcidin-2 (Hep-2 at the peptide level. To this purpose, Fourier transform ion cyclotron resonance (FTICR and tandem-MS was used for hepcidin identification, after which a time-of-flight (TOF MS-based methodology was exploited to routinely determine Hep-1 and -2 levels in mouse serum and urine. This method was biologically validated by hepcidin assessment in: i 3 mouse strains (C57Bl/6; DBA/2 and BABL/c upon stimulation with intravenous iron and LPS, ii homozygous Hfe knock out, homozygous transferrin receptor 2 (Y245X mutated mice and double affected mice, and iii mice treated with a sublethal hepatotoxic dose of paracetamol. The results showed that detection of Hep-1 was restricted to serum, whereas Hep-2 and its presumed isoforms were predominantly present in urine. Elevations in serum Hep-1 and urine Hep-2 upon intravenous iron or LPS were only moderate and varied considerably between mouse strains. Serum Hep-1 was decreased in all three hemochromatosis models, being lowest in the double affected mice. Serum Hep-1 levels correlated with liver hepcidin-1 gene expression, while acute liver damage by paracetamol depleted Hep-1 from serum. Furthermore, serum Hep-1 appeared to be an excellent indicator of splenic iron accumulation. In conclusion, Hep-1 and Hep-2 peptide responses in experimental mouse agree with the known biology of hepcidin mRNA regulators, and their measurement can now be implemented in experimental mouse models to provide novel insights in post-transcriptional regulation, hepcidin function, and kinetics.

  18. Analysis and experimental studies of the control of hang gliders

    Science.gov (United States)

    Phillips, W. H.

    1974-01-01

    A theoretical analysis of the longitudinal and lateral characteristics of hang gliders in straight flight, pullups, and turns is presented. Some examples of the characteristics of a straight-wing configuration and a Rogallo-wing configuration are given. A means for improving the control of hang gliders while retaining the same basic control feel is proposed.

  19. 延迟性肌肉酸痛实验模型及年龄特征分析%Delayed Onset Muscle Soreness Experimental Models and Age Characteristics

    Institute of Scientific and Technical Information of China (English)

    赵丽; 韩鹏; 张国强; 张翔

    2016-01-01

    研究目的:延迟性肌肉酸痛实验模型设计是其研究的重要组成部分而实验对象年龄也是延迟性肌肉酸痛的影响因素之一,探讨延迟性肌肉酸痛实验模型设计及实验对象的年龄特征,建立更便捷有效的延迟性肌肉酸痛实验模型。研究方法:文献资料法。结果与结论:1)成年人作为研究对象,能承受相对强度较大的运动,实验数据相对稳定,更有利于实验的进行;延迟性肌肉酸痛对老年人骨骼肌是否具有重塑的作用,还有待进一步研究。2)建议以人体的非惯用肢体大强度离心运动为主诱导延迟性肌肉酸痛的实验模型。3)延迟性肌肉酸痛的模型基本基于肢体进行不同负荷、形式的改变进行研究。建议选取可行性较高,操作简单且人为干预较少,诱导酸痛明显的方法,如:纵跳、斜面提踵、负重肘屈伸。4)疼痛识别可采用直观的视觉模拟量表。%Objective: Delayed Onset Muscle Soreness experimental model design is an important part of their research subjects and the age is one of the influence factors DOMS. To explore the experimental model of DOMS and the age characteristics of the experimental subjects, and to establish a more convenient and effective experimental model of DOMS. Methods: To retrieve in February 1984 to December 2015 Pub Med database related literature, the Chinese retrieval words:延迟性肌肉酸痛; The key words in English:Delayed Onset Muscle Soreness; Into the 138 paper, all the data of the related to this research and analysis. Results and conclusion: 1) As the research object, adults can bear larger relative intensity of sports, the experimental data is relatively stable, more conducive to the experiment;DOMS for the elderly skeletal muscle is reshaping the role, and it remains to be further research. 2) A proposal to the body of the non-dominant limb strength of large centrifugal movement induced experimental model

  20. Study on Age of Sample by Thermal Analysis Method

    Institute of Scientific and Technical Information of China (English)

    LU; Jin; LI; Yi-guo; YANG; Tong-suo; SHI; Yong-qian; HUA; Xiao; LI; Lai-dong

    2015-01-01

    The relation between the nuclear track density and the annealing heat in apatite is analyzed by solid state physics.The standard Durango apatite and Anhui apatite collected by Changan University are annealed first and then irradiated inαradioactive source and reactor.From the analysis of the annealing curve,the shape and the

  1. The Analysis of the Age Structure of Regional Fixed Capital in the Agriculture

    Directory of Open Access Journals (Sweden)

    P. Mazouch

    2016-06-01

    Full Text Available The paper deals with an estimate and analysis of the value of regional net fixed capital stock and the age structure of machinery and equipment in Czech agriculture. In order to perform such analysis, the official model of perpetual inventory method is transformed into the Markov chain model and applied on regional data separately. Regional net fixed capital stock is presented for the period of 2008-2013. The development of the average age of machinery and equipment comprises a potential indicator of the modernisation process in the industry. The analysis of the age structure is based on the structure heterogeneity indicator. For these purposes, the real age structure in each Czech region is compared with the theoretical stable and stationary structure. Currently, the most heterogeneous age structure of machinery and equipment occurs in Prague and the Karlovy Vary region.

  2. Big data-enabled multiscale serviceability analysis for aging bridges☆

    Directory of Open Access Journals (Sweden)

    Yu Liang

    2016-08-01

    Full Text Available This work is dedicated to constructing a multi-scale structural health monitoring system to monitor and evaluate the serviceability of bridges based on the Hadoop Ecosystem (MS-SHM-Hadoop. By taking the advantages of the fault-tolerant distributed file system called the Hadoop Distributed File System (HDFS and high-performance parallel data processing engine called MapReduce programming paradigm, MS-SHM-Hadoop features include high scalability and robustness in data ingestion, fusion, processing, retrieval, and analytics. MS-SHM-Hadoop is a multi-scale reliability analysis framework, which ranges from nationwide bridge-surveys, global structural integrity analysis, and structural component reliability analysis. This Nationwide bridge survey uses deep-learning techniques to evaluate the bridge serviceability according to real-time sensory data or archived bridge-related data such as traffic status, weather conditions and bridge structural configuration. The global structural integrity analysis of a targeted bridge is made by processing and analyzing the measured vibration signals incurred by external loads such as wind and traffic flow. Component-wise reliability analysis is also enabled by the deep learning technique, where the input data is derived from the measured structural load effects, hyper-spectral images, and moisture measurement of the structural components. As one of its major contributions, this work employs a Bayesian network to formulate the integral serviceability of a bridge according to its components serviceability and inter-component correlations. Here the inter-component correlations are jointly specified using a statistics-oriented machine learning method (e.g., association rule learning or structural mechanics modeling and simulation.

  3. Performance analysis and experimental study on Flat Optical Comb Generation

    Directory of Open Access Journals (Sweden)

    Haining Li

    2013-01-01

    Full Text Available The performance of the optical frequency comb generation based on the re-circulating frequency shifter has been analyzed and demonstrated in this paper. We have theoretically analyzed the condition for flatness of the optical frequency comb and the relative intensity noise influence. We find out the influence to the flatness of optical comb owing to amplifier relative intensity noise and modulator relative factors imperfect, such as input RF signals amplitude and phase deviation and modulator defect owing to manufacture for the first time. Moreover, to verify the theoretical analysis, a 16 comb lines and spacing 12.5 GHz RFS generation system have also been carried out, and the results are in good agreement with the theoretical analysis results.

  4. Age-structured mark-recapture analysis: A virtual-population-analysis-based model for analyzing age-structured capture-recapture data

    Science.gov (United States)

    Coggins, L.G.; Pine, William E.; Walters, C.J.; Martell, S.J.D.

    2006-01-01

    We present a new model to estimate capture probabilities, survival, abundance, and recruitment using traditional Jolly-Seber capture-recapture methods within a standard fisheries virtual population analysis framework. This approach compares the numbers of marked and unmarked fish at age captured in each year of sampling with predictions based on estimated vulnerabilities and abundance in a likelihood function. Recruitment to the earliest age at which fish can be tagged is estimated by using a virtual population analysis method to back-calculate the expected numbers of unmarked fish at risk of capture. By using information from both marked and unmarked animals in a standard fisheries age structure framework, this approach is well suited to the sparse data situations common in long-term capture-recapture programs with variable sampling effort. ?? Copyright by the American Fisheries Society 2006.

  5. Viscoelasticity of Axisymmetric Composite Structures: Analysis and Experimental Validation

    Science.gov (United States)

    2013-02-01

    are currently used for lightweight pressure vessels and highly efficient rotors for energy storage . For both applications, pre-stresses are built in...analysis can be applied to composite pressure vessels, gun barrels, and flywheels . 15. SUBJECT TERMS viscoelasticity, creep, composite, gun barrel... flywheel 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT UU 18. NUMBER OF PAGES 28 19a. NAME OF RESPONSIBLE PERSON Jerome T

  6. Characteristic analysis and experimental evaluation of artificial pneumatic cylinder

    Science.gov (United States)

    Kim, Dong-Soo; Bae, Sang-Kyu; Choi, Kyung-Hyun

    2005-12-01

    The fluidic muscle cylinder consists of an air bellows tube, flanges and lock nuts. Its features are softness of material and motion, simplicity of structure, low production cost and high power efficiency. Recently, unlikely the pneumatic cylinder, the fluidic muscle cylinder without air leakage, stick slip, friction, and seal was developed as a new concept actuator. It has the characteristics such as light weight, low price, high response, durable design, long life, high power, high contraction, which is innovative product fulfilling RT(Robot Technology) which is one of the nation-leading next generation strategy technologies 6T as well as cleanness technology. The application fields of the fluidic muscle cylinder are so various like fatigue tester, brake, accelerator, high technology testing device such as driving simulator, precise position, velocity, intelligent servo actuator under special environment such as load controlling system, and intelligent robot. In this study, we carried out the finite element modeling and analysis about the main design variables such as contraction ration and force, diameter increment of fluidic muscle cylinder. On the basis of finite element analysis, the prototype of fluidic muscle cylinder was fabricated and tested. Finally, we compared the results between the test and the finite element analysis.

  7. Performance Analysis of Multilayer MIPv6 Architecture through Experimental Testbed

    Directory of Open Access Journals (Sweden)

    Nitul Dutta

    2014-07-01

    Full Text Available Mobility management is a key issue to achieve uninterrupted Internet services in IP based network. In IPv6, the mobility management is realized by its mobile version namely the Mobile IPv6 (MIPv6. The MIPv6 is further extended to Hierarchical MIPv6 (HMIPv6 to reduce handoff latency suffered by mobile nodes and signaling load incurred due to movement if nodes within the micro mobility region defined by HMIPv6. The HMIPv6 is considered as first widely accepted layered architecture for mobility management for IPv6 network. Influenced by the benefits of HMIPv6, many researchers have suggested extension of MIPv6 into multiple layers. However, there is very little work on finding optimal levels of hierarchy in such layered architecture. The focus of this paper is to evaluate the performance of a multilayer (N-layered with N as 5 MIPv6 architecture through experimental testbed. We have observed handoff latency, signaling overhead and tunneling cost and figured out the optimal levels of hierarchy that provides the best acceptable results for all the observed parameters. Since, HMIPv6 outperforms MIPv6 in terms of handoff latency and signaling cost, so we compare our results with HMIPv6. Testbed observation depicts that three levels of hierarchy in MIPv6 architecture provides optimal performance with 27% reduction in handoff latency and 67% reduction in signaling overhead compared to single layer architecture like Hierarchical MIPv6 (HMIPv6 protocol.

  8. Experimental Thermal Analysis of Diesel Engine Piston and Cylinder Wall

    Directory of Open Access Journals (Sweden)

    Subodh Kumar Sharma

    2015-01-01

    Full Text Available Knowledge of piston and cylinder wall temperature is necessary to estimate the thermal stresses at different points; this gives an idea to the designer to take care of weaker cross section area. Along with that, this temperature also allows the calculation of heat losses through piston and cylinder wall. The proposed methodology has been successfully applied to a water-cooled four-stroke direct-injection diesel engine and it allows the estimation of the piston and cylinder wall temperature. The methodology described here combines numerical simulations based on FEM models and experimental procedures based on the use of thermocouples. Purposes of this investigation are to measure the distortion in the piston, temperature, and radial thermal stresses after thermal loading. To check the validity of the heat transfer model, measure the temperature through direct measurement using thermocouple wire at several points on the piston and cylinder wall. In order to prevent thermocouple wire entanglement, a suitable pathway was designed. Appropriate averaged thermal boundary conditions such as heat transfer coefficients were set on different surfaces for FE model. The study includes the effects of the thermal conductivity of the material of piston, piston rings, and combustion chamber wall. Results show variation of temperature, stresses, and deformation at various points on the piston.

  9. Recency, repeatability, and reinforcer retrenchment: an experimental analysis of resurgence.

    Science.gov (United States)

    Lieving, Gregory A; Lattal, Kennon A

    2003-09-01

    Four experiments were conducted with pigeons to assess the experimental conditions necessary for the occurrence of resurgence. The general procedure consisted of the following conditions: Condition 1--reinforcement of key pecking; Condition 2--reinforcement of treadle pressing and concurrent extinction of key pecking; and Condition 3--the resurgence condition wherein resurgence was defined as the recovery of key pecking. In Experiments 1 and 2, the resurgence condition was conventional extinction. The effect of recency on resurgence magnitude was examined in Experiment 1 by manipulating the number of sessions of Condition 2, above. Resurgence was not a function of recency with the parameters used. Repeating the three conditions revealed resurgence to be a repeatable effect in Experiment 2. In Experiment 3, a variable-time schedule was in effect for the resurgence condition. Resurgence was not produced by response-independent food delivery. In Experiment 4, the resurgence condition was a variable-interval schedule for treadle pressing that arranged a lower reinforcement rate than in Condition 2 (92% reduction in reinforcers per minute). Resurgence was lower in magnitude relative to conventional extinction, although resurgence was obtained with 2 out of 3 pigeons. The results are discussed in terms of the variables controlling resurgence and the relations between behavioral history, resurgence, and other forms of response recovery.

  10. Experimental stability analysis of different water-based nanofluids

    Science.gov (United States)

    Fedele, Laura; Colla, Laura; Bobbo, Sergio; Barison, Simona; Agresti, Filippo

    2011-12-01

    In the recent years, great interest has been devoted to the unique properties of nanofluids. The dispersion process and the nanoparticle suspension stability have been found to be critical points in the development of these new fluids. For this reason, an experimental study on the stability of water-based dispersions containing different nanoparticles, i.e. single wall carbon nanohorns (SWCNHs), titanium dioxide (TiO2) and copper oxide (CuO), has been developed in this study. The aim of this study is to provide stable nanofluids for selecting suitable fluids with enhanced thermal characteristics. Different dispersion techniques were considered in this study, including sonication, ball milling and high-pressure homogenization. Both the dispersion process and the use of some dispersants were investigated as a function of the nanoparticle concentration. The high-pressure homogenization was found to be the best method, and the addition of n-dodecyl sulphate and polyethylene glycol as dispersants, respectively in SWCNHs-water and TiO2-water nanofluids, improved the nanofluid stability.

  11. Experimental stability analysis of different water-based nanofluids

    Directory of Open Access Journals (Sweden)

    Barison Simona

    2011-01-01

    Full Text Available Abstract In the recent years, great interest has been devoted to the unique properties of nanofluids. The dispersion process and the nanoparticle suspension stability have been found to be critical points in the development of these new fluids. For this reason, an experimental study on the stability of water-based dispersions containing different nanoparticles, i.e. single wall carbon nanohorns (SWCNHs, titanium dioxide (TiO2 and copper oxide (CuO, has been developed in this study. The aim of this study is to provide stable nanofluids for selecting suitable fluids with enhanced thermal characteristics. Different dispersion techniques were considered in this study, including sonication, ball milling and high-pressure homogenization. Both the dispersion process and the use of some dispersants were investigated as a function of the nanoparticle concentration. The high-pressure homogenization was found to be the best method, and the addition of n-dodecyl sulphate and polyethylene glycol as dispersants, respectively in SWCNHs-water and TiO2-water nanofluids, improved the nanofluid stability.

  12. Critical Discourse Analysis and Critical Thinking: An Experimental Study in an EFL Context

    Science.gov (United States)

    Hashemi, Mohammad Reza; Ghanizadeh, Afsaneh

    2012-01-01

    The present study investigated the impact of critical discourse analysis (CDA) on TEFL students' critical thinking (CT) ability in "Reading Journalistic Texts" classes. In so doing, the study utilized an experimental design with 24 participants in the control group and 29 participants in the experimental group. The results of a pretest indicated…

  13. Age and work-related motives : Results of a meta-analysis

    NARCIS (Netherlands)

    Kooij, Dorien T. A. M.; De Lange, Annet H.; Jansen, Paul G. W.; Kanfer, Ruth; Dikkers, Josje S. E.

    2011-01-01

    An updated literature review was conducted and a meta-analysis was performed to investigate the relationship between age and work-related motives. Building on theorizing in life span psychology, we hypothesized the existence of age-related differences in work-related motives. Specifically, we propos

  14. Employee Burnout: A Meta-Analysis of the Relationship between Age or Years of Experience

    Science.gov (United States)

    Brewer, Ernest W.; Shapard, Leslie

    2004-01-01

    This study examined the relationship between age or years of experience and employee burnout by performing a meta-analysis on research studies that present findings on relationships between employee burnout and age or years of experience. The problem has practical significance in that the appropriateness of approaches to addressing employee…

  15. Desloratadine analysis: as a pharmaceutical preparation and after accelerating ageing

    OpenAIRE

    Bober Katarzyna; Płonka Marlena; Miszczyk Marek

    2015-01-01

    Desloratadine is a biologically active compound that is not described in the Polish Pharmacopoeia IX, hence, its study is particular important. The aim of this work was to establish a procedure for desloratadine analysis by way of HPTLC in combination with densitometry, so as to be able to ascertain its presence and degree of presence within pharmaceutical preparations. In our work, a mixture of ethyl acetate, n-butanol, ammonia and methanol was used as the mobile phase. Moreover, HPTLC plate...

  16. Sensitivity analysis of the age-structured malaria transmission model

    Science.gov (United States)

    Addawe, Joel M.; Lope, Jose Ernie C.

    2012-09-01

    We propose an age-structured malaria transmission model and perform sensitivity analyses to determine the relative importance of model parameters to disease transmission. We subdivide the human population into two: preschool humans (below 5 years) and the rest of the human population (above 5 years). We then consider two sets of baseline parameters, one for areas of high transmission and the other for areas of low transmission. We compute the sensitivity indices of the reproductive number and the endemic equilibrium point with respect to the two sets of baseline parameters. Our simulations reveal that in areas of either high or low transmission, the reproductive number is most sensitive to the number of bites by a female mosquito on the rest of the human population. For areas of low transmission, we find that the equilibrium proportion of infectious pre-school humans is most sensitive to the number of bites by a female mosquito. For the rest of the human population it is most sensitive to the rate of acquiring temporary immunity. In areas of high transmission, the equilibrium proportion of infectious pre-school humans and the rest of the human population are both most sensitive to the birth rate of humans. This suggests that strategies that target the mosquito biting rate on pre-school humans and those that shortens the time in acquiring immunity can be successful in preventing the spread of malaria.

  17. Experimental study and mechanism analysis on bioeffects by nanosecond electromagnetic pulses

    Institute of Scientific and Technical Information of China (English)

    王保义; 杨杰斌; 郭庆功; 徐润民; 刘长军; 张弘; 邹方东; 王子淑

    1997-01-01

    The athermal bioeffects caused by nanosecond electromagnetic pulses with body cells was studied by using a broad band transverse EM-wave cell (BTEM CELL). The experimental system and preliminary mechanism analysis were presented.

  18. Mineral analysis in experimental corneal scars. An EDAX study

    Energy Technology Data Exchange (ETDEWEB)

    Bonafonte, S.; Fernandez del Cotero, J.N.; Aguirre Vila-Coro, A.

    1988-01-01

    Central penetrating excisional wounds were made in the corneas of 12 rabbits and 10 trout. The scar tissue and the surrounding cornea were compared using a new method for assessing inorganic elements in the cornea: the scanning electron microscopy and energy dispersive analysis of x-ray (EDAX). Semiquantitative determination of inorganic elements within the range of atomic numbers 9-93 in the periodic system was performed, comparing the relative concentration of those elements in the scar tissue to the surrounding cornea. Results showed that calcium was the only element higher in the healing wound than in the surrounding cornea.

  19. Experimental analysis of the levees safety based on geophysical monitoring

    Science.gov (United States)

    Rizzo, Enzo; Valeria, Giampaolo; Mario, Votta; Lapenna, Vincenzo; Moramarco, Tommaso; Aricò, Costanza; Camici, S.; Morbidelli, Renato; Sinagra, M.; Tucciarelli, T.

    2010-05-01

    Several flood events brought river levees into the focus of attention for some disasters due to their collapse. This phenomena is quite complex to investigate, because of different factors that can affect the stability of levees, among them the non uniformity of material properties, which influencing the permeability of the embankment, might induce high percolation velocity of flux thus triggering the unstability. Thus, to apply a fast and integrate investigation methods with a non-destructive characteristics should have a large interest, if they are able to furnish ready and usable information necessary to hydrogeological models. In order to achieve this goal, the University of Perugia (Department of Civil and Environmental Engineering) and the National Research Council (IRPI and IMAA research institutes) developed a collaborating project on the study of the internal structure of the river embankment by carrying out experiments in laboratory. The purpose of this study is to show the preliminary results of the experimental investigation. The laboratory embankment was built using material coming from a real levee and gathered inside a 1.5m x 1.2m plexiglas box. The box has two compartments: a water reservoir at one hand where a constant water head was reached after some time and a soil simulating the presence of levee. We perform a geoelectrical multichannel acquisition system with three parallel profiles characterized by 16 mini-electrodes connected to georesistivimeter Syscal Pro. An automatic acquisition protocol has been performed to obtain time slice electrical tomographies during the experiments. The geophysical results show the effect of the water table inside the embankment during the wetting and emptying. In order to assess the capability of the geophysical monitoring for addressing the soil parameters estimate, the resistivity results are investigated by using two analytical and one hydraulic numerical models. The analytical models represent a linear

  20. Merit and justice: an experimental analysis of attitude to inequality.

    Science.gov (United States)

    Rustichini, Aldo; Vostroknutov, Alexander

    2014-01-01

    Merit and justice play a crucial role in ethical theory and political philosophy. Some theories view justice as allocation according to merit; others view justice as based on criteria of its own, and take merit and justice as two independent values. We study experimentally how these views are perceived. In our experiment subjects played two games (both against the computer): a game of skill and a game of luck. After each game they observed the earnings of all the subjects in the session, and thus the differences in outcomes. Each subject could reduce the winnings of one other person at a cost. The majority of the subjects used the option to subtract. The decision to subtract and the amount subtracted depended on whether the game was one of skill or luck, and on the distance between the earnings of the subject and those of others. Everything else being equal, subjects subtracted more in luck than in skill. In skill game, but not in luck, the subtraction becomes more likely, and the amount larger, as the distance increases. The results show that individuals considered favorable outcomes in luck to be undeserved, and thus felt more justified in subtracting. In the skill game instead, they considered more favorable outcomes (their own as well as others') as signal of ability and perhaps effort, which thus deserved merit; hence, they felt less motivated to subtract. However, a larger size of the unfavorable gap from the others increased the unpleasantness of poor performance, which in turn motivated larger subtraction. In conclusion, merit is attributed if and only if effort or skill significantly affect the outcome. An inequality of outcomes is viewed differently depending on whether merit causes the difference or not. Thus, merit and justice are strongly linked in the human perception of social order.

  1. Experimental Analysis of Bisbenzocyclobutene Bonded Capacitive Micromachined Ultrasonic Transducers

    Science.gov (United States)

    Manwar, Rayyan; Chowdhury, Sazzadur

    2016-01-01

    Experimental measurement results of a 1.75 mm × 1.75 mm footprint area Capacitive Micromachined Ultrasonic Transducer (CMUT) planar array fabricated using a bisbenzocyclobutene (BCB)-based adhesive wafer bonding technique has been presented. The array consists of 40 × 40 square diaphragm CMUT cells with a cavity thickness of 900 nm and supported by 10 µm wide dielectric spacers patterned on a thin layer of BCB. A 150 µm wide one µm thick gold strip has been used as the contact pad for gold wire bonding. The measured resonant frequency of 19.3 MHz using a Polytec™ laser Doppler vibrometer (Polytec™ MSA-500) is in excellent agreement with the 3-D FEA simulation result using IntelliSuite™. An Agilent ENA5061B vector network analyzer (VNA) has been used for impedance measurement and the resonance and anti-resonance values from the imaginary impedance curve were used to determine the electromechanical coupling co-efficient. The measured coupling coefficient of 0.294 at 20 V DC bias exhibits 40% higher transduction efficiency as compared to a measured value published elsewhere for a silicon nitride based CMUT. A white light interferometry method was used to measure the diaphragm deflection profiles at different DC bias. The diaphragm center velocity was measured for different sub-resonant frequencies using a Polytec™ laser Doppler vibrometer that confirms vibration of the diaphragm at different excitation frequencies and bias voltages. Transmit and receive operations of CMUT cells were characterized using a pitch-catch method and a −6 dB fractional bandwidth of 23% was extracted from the received signal in frequency domain. From the measurement, it appears that BCB-based CMUTs offer superior transduction efficiency as compared to silicon nitride or silicon dioxide insulator-based CMUTs, and provide a very uniform deflection profile thus making them a suitable candidate to fabricate highly energy efficient CMUTs. PMID:27347955

  2. Single photon laser altimeter data processing, analysis and experimental validation

    Science.gov (United States)

    Vacek, Michael; Peca, Marek; Michalek, Vojtech; Prochazka, Ivan

    2015-10-01

    Spaceborne laser altimeters are common instruments on-board the rendezvous spacecraft. This manuscript deals with the altimeters using a single photon approach, which belongs to the family of time-of-flight range measurements. Moreover, the single photon receiver part of the altimeter may be utilized as an Earth-to-spacecraft link enabling one-way ranging, time transfer and data transfer. The single photon altimeters evaluate actual altitude through the repetitive detections of single photons of the reflected laser pulses. We propose the single photon altimeter signal processing and data mining algorithm based on the Poisson statistic filter (histogram method) and the modified Kalman filter, providing all common altimetry products (altitude, slope, background photon flux and albedo). The Kalman filter is extended for the background noise filtering, the varying slope adaptation and the non-causal extension for an abrupt slope change. Moreover, the algorithm partially removes the major drawback of a single photon altitude reading, namely that the photon detection measurement statistics must be gathered. The developed algorithm deduces the actual altitude on the basis of a single photon detection; thus, being optimal in the sense that each detected signal photon carrying altitude information is tracked and no altitude information is lost. The algorithm was tested on the simulated datasets and partially cross-probed with the experimental data collected using the developed single photon altimeter breadboard based on the microchip laser with the pulse energy on the order of microjoule and the repetition rate of several kilohertz. We demonstrated that such an altimeter configuration may be utilized for landing or hovering a small body (asteroid, comet).

  3. A Comparison of Four Reading Interventions from Struggling Elementary Students Using Brief Experimental Analysis and Extended Intervention Analysis

    Science.gov (United States)

    Mong, Kristi W.; Mong, Michael D.; Henington, Carlen; Doggett, R. A.

    2012-01-01

    Brief experimental analyses (BEA) have been used to identify reading interventions to increase the oral reading fluency (ORF) of students having difficulty learning to read. Four interventions, repeated reading, listening passage preview, phrase drill, and contingent reinforcement were implemented with four elementary aged students performing…

  4. Automated Experimental Data Analysis at the National Ignition Facility

    Energy Technology Data Exchange (ETDEWEB)

    Azevedo, S G; Bettenhausen, R C; Beeler, R G; Bond, E J; Edwards, P W; Glenn, S M; Liebman, J A; Tappero, J D; Warrick, A L; Williams, W H

    2009-09-24

    The National Ignition Facility (NIF) at the Lawrence Livermore National Laboratory is a 192-beam 1.8 MJ ultraviolet laser system designed to support high-energy-density science, including demonstration of inertial confinement fusion ignition. After each target shot lasting {approx}20 ns, scientists require data acquisition, analysis and display within 30 minutes from more than 20 specialized high-speed diagnostic instruments. These diagnostics measure critical x-ray, optical and nuclear phenomena during target burn to quantify ignition results and compare to computational models. All diagnostic data (hundreds of Gbytes) are automatically transferred to an Oracle database that triggers the NIF Shot Data Analysis (SDA) Engine, which distributes the signal and image processing tasks to a Linux cluster. The SDA Engine integrates commercial workflow tools and messaging technologies into a scientific software architecture that is highly parallel, scalable, and flexible. Results are archived in the database for scientist approval and displayed using a web-based tool. The unique architecture and functionality of the SDA Engine will be presented along with an example.

  5. The Differential Phase Experiment: experimental concept, design analysis, and data reduction analysis

    Science.gov (United States)

    Tyler, Glenn A.; Brennan, Terry J.; Browne, Stephen L.; Dueck, Robert H.; Lodin, Michael S.; Roberts, Phillip H.; Vaughn, Jeffrey L.

    1997-08-01

    This paper describes the differential phase experiment (DPE) which formed a major part of the ABLE ACE suite of experiments conducted by the Air Force. The work described covers the rationale for the experiment, the basic experimental concept, the analysis of the differential phase, the optical and software design analysis, a discussion of the polarization scrambling characteristics of the optics, calibration of the equipment and a presentation of some of the major results of the data reduction effort to date. The DPE was a propagation experiment conducted between two aircraft flying at an altitude of 40,000 feet whose purpose was to measure the phase difference between two beams propagating at slightly different angels through the atmosphere. A four bin polarization interferometer was used to measure the differential phase. Due to the high level of scintillation that was presented branch points were present in the phase function. Rytov theory, wave optics simulation and the experimental measurements are in general agreement. Self consistency checks that were performed on the data indicate a high level of confidence in the results. Values of Cn2 that are consistent with the measurements of the differential phase agree with simultaneous scintillometer measurement taken long the same path in levels of turbulence where the scintillometer is not saturated. These differential phase based Cn2 estimates do not appear to saturate as is typical of scintillometer measurements and appear to extend the range over which high levels of Cn2 can be estimated. In addition the differential phase and anisoplanatic Strehl computed from the data is consistent with Rytov theory and wave optics simulations.

  6. Meta-analysis of the age-related positivity effect: age differences in preferences for positive over negative information.

    Science.gov (United States)

    Reed, Andrew E; Chan, Larry; Mikels, Joseph A

    2014-03-01

    In contrast to long-held axioms of old age as a time of "doom and gloom," mounting evidence indicates an age-related positivity effect in attention and memory. However, several studies report inconsistent findings that raise critical questions about the effect's reliability, robustness, and potential moderators. To address these questions, we conducted a systematic meta-analysis of 100 empirical studies of the positivity effect (N = 7,129). Results indicate that the positivity effect is reliable and moderated by theoretically implicated methodological and sample characteristics. The positivity effect is larger in studies that do not constrain (vs. constrain) cognitive processing-reflecting older adults' natural information processing preferences-and in studies incorporating wider (vs. narrower) age comparisons. Analyses indicated that older adults show a significant information processing bias toward positive versus negative information, whereas younger adults show the opposite pattern. We discuss implications of these findings for theoretical perspectives on emotion-cognition interactions across the adult life span and suggest future research directions.

  7. Experimental and computational analysis of monkey smooth pursuit eye movements.

    Science.gov (United States)

    Churchland, M M; Lisberger, S G

    2001-08-01

    Smooth pursuit eye movements are guided by visual feedback and are surprisingly accurate despite the time delay between visual input and motor output. Previous models have reproduced the accuracy of pursuit either by using elaborate visual signals or by adding sources of motor feedback. Our goal was to constrain what types of signals drive pursuit by obtaining data that would discriminate between these two modeling approaches, represented by the "image motion model" and the "tachometer feedback" model. Our first set of experiments probed the visual properties of pursuit with brief square-pulse and sine-wave perturbations of target velocity. Responses to pulse perturbations increased almost linearly with pulse amplitude, while responses to sine wave perturbations showed strong saturation with increasing stimulus amplitude. The response to sine wave perturbations was strongly dependent on the baseline image velocity at the time of the perturbation. Responses were much smaller if baseline image velocity was naturally large, or was artificially increased by superimposing sine waves on pulse perturbations. The image motion model, but not the tachometer feedback model, could reproduce these features of pursuit. We used a revision of the image motion model that was, like the original, sensitive to both image velocity and image acceleration. Due to a saturating nonlinearity, the sensitivity to image acceleration declined with increasing image velocity. Inclusion of this nonlinearity was motivated by our experimental results, was critical in accounting for the responses to perturbations, and provided an explanation for the unexpected stability of pursuit in the presence of perturbations near the resonant frequency. As an emergent property, the revised image motion model was able to reproduce the frequency and damping of oscillations recorded during artificial feedback delays. Our second set of experiments replicated prior recordings of pursuit responses to multiple

  8. Experimental and numerical analysis of cavitating flow around a hydrofoil

    Directory of Open Access Journals (Sweden)

    Müller Miloš

    2012-04-01

    Full Text Available The paper describes experiments carried out in the cavitation tunnel with the rectangular test section of 150 × 150 × 500 mm and the maximum test section inlet velocity of 25 m/s. These experiments have been aimed to visualize the cavitation phenomena as well as to quantify the erosion potential using pitting tests evaluated during the incubation period for the cast-iron prismatic hydrofoil with the modified NACA profile. A bypass section installed in the tunnel has allowed to measure the nuclei content in the inlet flow to the test section using the acoustic spectrometer. The measured data have been compared with the CFD analysis of the cavitation phenomena on the hydrofoil as well as the numerically determined location and magnitude of the first calculated collapses of the cavitating bubbles with a good agreement.

  9. Wireless sensor networks concepts, applications, experimentation and analysis

    CERN Document Server

    Fahmy, Hossam Mahmoud Ahmad

    2016-01-01

    This book focuses on the principles of wireless sensor networks (WSNs), their applications, and their analysis tools, with meticulous attention paid to definitions and terminology. This book presents the adopted technologies and their manufacturers in detail, making WSNs tangible for the reader. In introductory computer networking books, chapter sequencing follows the bottom-up or top-down architecture of the 7-layer protocol. This book addresses subsequent steps in this process, both horizontally and vertically, thus fostering a clearer and deeper understanding through chapters that elaborate on WSN concepts and issues. With such depth, this book is intended for a wide audience; it is meant to be a helper and motivator for senior undergraduates, postgraduates, researchers, and practitioners. It lays out important concepts and WSN-relate applications; uses appropriate literature to back research and practical issues; and focuses on new trends. Senior undergraduate students can use it to familiarize themselves...

  10. Face Aging Effect Simulation Using Hidden Factor Analysis Joint Sparse Representation

    Science.gov (United States)

    Yang, Hongyu; Huang, Di; Wang, Yunhong; Wang, Heng; Tang, Yuanyan

    2016-06-01

    Face aging simulation has received rising investigations nowadays, whereas it still remains a challenge to generate convincing and natural age-progressed face images. In this paper, we present a novel approach to such an issue by using hidden factor analysis joint sparse representation. In contrast to the majority of tasks in the literature that handle the facial texture integrally, the proposed aging approach separately models the person-specific facial properties that tend to be stable in a relatively long period and the age-specific clues that change gradually over time. It then merely transforms the age component to a target age group via sparse reconstruction, yielding aging effects, which is finally combined with the identity component to achieve the aged face. Experiments are carried out on three aging databases, and the results achieved clearly demonstrate the effectiveness and robustness of the proposed method in rendering a face with aging effects. Additionally, a series of evaluations prove its validity with respect to identity preservation and aging effect generation.

  11. Experimental impact testing and analysis of composite fan cases

    Science.gov (United States)

    Vander Klok, Andrew Joe

    For aircraft engine certification, one of the requirements is to demonstrate the ability of the engine to withstand a fan blade-out (FBO) event. A FBO event may be caused by fatigue failure of the fan blade itself or by impact damage of foreign objects such as bird strike. An un-contained blade can damage flight critical engine components or even the fuselage. The design of a containment structure is related to numerous parameters such as the blade tip speed; blade material, size and shape; hub/tip diameter; fan case material, configuration, rigidity, etc. To investigate all parameters by spin experiments with a full size rotor assembly can be prohibitively expensive. Gas gun experiments can generate useful data for the design of engine containment cases at much lower costs. To replicate the damage modes similar to that on a fan case in FBO testing, the gas gun experiment has to be carefully designed. To investigate the experimental procedure and data acquisition techniques for FBO test, a low cost, small spin rig was first constructed. FBO tests were carried out with the small rig. The observed blade-to-fan case interactions were similar to those reported using larger spin rigs. The small rig has the potential in a variety of applications from investigating FBO events, verifying concept designs of rotors, to developing spin testing techniques. This rig was used in the developments of the notched blade releasing mechanism, a wire trigger method for synchronized data acquisition, high speed video imaging and etc. A relationship between the notch depth and the release speed was developed and verified. Next, an original custom designed spin testing facility was constructed. Driven by a 40HP, 40,000rpm air turbine, the spin rig is housed in a vacuum chamber of phi72inx40in (1829mmx1016mm). The heavily armored chamber is furnished with 9 viewports. This facility enables unprecedented investigations of FBO events. In parallel, a 15.4ft (4.7m) long phi4.1inch (105mm

  12. All Night Spectral Analysis of EEG Sleep in Young Adult and Middle-Aged Male Subjects

    OpenAIRE

    Dijk, Derk Jan; Beersma, Domien G. M.; Hoofdakker, Rutger H. van den

    1989-01-01

    The sleep EEGs of 9 young adult males (age 20-28 years) and 8 middle-aged males (42-56 years) were analyzed by visual scoring and spectral analysis. In the middle-aged subjects power density in the delta, theta and sigma frequencies were attenuated as compared to the young subjects. In both age groups power density in the delta and theta frequencies declined from NREM period 1 to 3. In the sigma frequencies, however, no systematic changes in power density were observed over the sleep episode....

  13. Analysis of Lower Body Kinematic and Kinetic: Differences Between Age and Handicap in Golfers of Various Ages and Skill Levels

    Science.gov (United States)

    Smilensky, Alexander

    The purpose of this thesis was to provide a preliminary analysis of lower body golf swing biomechanics. Fourteen golfers of various ages and handicaps performed 10 swings off a tee with their driver. This study focused on a number of dependent variables including lead knee joint flexion angles, internal/external rotations, valgus/varus angles, as well as ground reaction forces normalized to body weight (%BW), X-Factor angle and club head velocity. Dependent variables were analyzed at four specifically defined events (start, initiation of downswing, contact and swing termination). Simple linear regressions were performed using age and handicap as independent variables to see if patterns could be determined at any of the events. No significant trends or results were reported within our sample. An analysis of variance (ANOVA) was then used to examine the effect of event on specific dependent variables. A number of differences were reported within each of the variables across the four events. This study hoped to provide a more comprehensive understanding of the movement patterns occurring at the lower body with special focus on the lead knee.

  14. Bayesian latent variable models for the analysis of experimental psychology data.

    Science.gov (United States)

    Merkle, Edgar C; Wang, Ting

    2016-03-18

    In this paper, we address the use of Bayesian factor analysis and structural equation models to draw inferences from experimental psychology data. While such application is non-standard, the models are generally useful for the unified analysis of multivariate data that stem from, e.g., subjects' responses to multiple experimental stimuli. We first review the models and the parameter identification issues inherent in the models. We then provide details on model estimation via JAGS and on Bayes factor estimation. Finally, we use the models to re-analyze experimental data on risky choice, comparing the approach to simpler, alternative methods.

  15. Aging Theories of TCM and Experimental Research Progress of Anti-aging%中医衰老理论与抗衰老的实验研究进展

    Institute of Scientific and Technical Information of China (English)

    李佳佳; 马健

    2013-01-01

    目的:总结中医衰老理论与抗衰老的实验研究进展.方法:收集近10 a来关于中医学衰老理论及相关中医药实验研究文献,并进行系统的归纳与总结.结果:中医衰老理论主要包括体质说、脏腑阴阳虚损致衰说、邪实致衰说、情志致衰说几方面,抗衰老中药通过现代药理实验证实疗效肯定,说明中医的相关学说有一定的科学性.结论:衰老的发生是很复杂的过程,单凭某一种理论尚无法完全阐释清楚,很多机制尚未清楚,仍需更多的研究来验证.%Objective:To explore the aging theories of TCM and experimental research progress of anti-aging. Methods:Aging theories of TCM and related traditional Chinese medical experimental research literatures in recent 10 years were collected, systematically concluded, and summarized. Results: Aging theories of TCM mainly included the aspects of theory of constitution, Viscera -Yin and Yang deficiency resulting senility, excess-evil resulting senility, emotion resulting senility. Anti-aging effects of Chinese medicinal herbs used were confirmed that they had the modern pharmacology experimental basis, which explained that related theory of TCM had certain scientifiei-ty. Conclusion: The occurrence of aging is a very complicated process, so it is impossible for a certain theory to clarify aging completely, and various mechanisms have not clear yet,which still needs more researches to verify.

  16. Pricing Strategies under Emissions Trading - an experimental analysis

    Energy Technology Data Exchange (ETDEWEB)

    Wraake, Markus; Myers, Erica; Mandell, Svante; Holt, Charles; Burtraw, Dallas

    2008-10-15

    An important feature in the design of an emissions trading program is how emission allowances are initially distributed into the market. The choice between an auction and free allocation should, according to economic theory, not have any influence on the firms' production choices nor on consumer prices. However, many observers are still incredulous that firms should be expected to raise product prices to include the value of emissions allowances they receive for free. Throughout much of Europe and the U.S., energy markets have been deregulated or are in the process of moving toward market liberalization. If market behavior does not conform to predictions of behavior in a competitive market, this may say a great deal about the nature of market liberalization in energy markets as well as about the behavior of environmental markets. If firms are able to voluntarily moderate commodity prices to be below competitive levels, it suggests an ability of these entities to exercise market power or collude - even if this is motivated by a desire to hold back and not pass through the value of emissions allowances in product prices. This paper reports on the use of experimental methods to investigate behavior with respect to how prices will be determined under a cap-and-trade program. We find participants in the experiments employ various approaches. Some participants initially recognize the opportunity cost of emission allowances and included them in their economic choices regardless of how the allowances have been obtained, and other subjects initially do not. However, given a simple economic setting in which payoffs depend on this behavior, we find that subjects learn to consider the value of allowances and overall behavior moves toward that predicted by economic theory. The observations from the experiments may help to understand the ongoing public debate over the interaction of the EU ETS and energy markets. Emission allowance markets are a new phenomenon to many

  17. Probing beer aging chemistry by nuclear magnetic resonance and multivariate analysis

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, J.A. [CICECO-Department of Chemistry, University of Aveiro, Campus de Santiago, 3810-193 Aveiro (Portugal); Barros, A.S. [QOPNA-Department of Chemistry, University of Aveiro, Campus de Santiago, 3810-193 Aveiro (Portugal); Carvalho, B.; Brandao, T. [UNICER, Bebidas de Portugal, Leca do Balio, 4466-955, S. Mamede de Infesta (Portugal); Gil, Ana M., E-mail: agil@ua.pt [CICECO-Department of Chemistry, University of Aveiro, Campus de Santiago, 3810-193 Aveiro (Portugal)

    2011-09-30

    Graphical abstract: The use of nuclear magnetic resonance (NMR) metabonomics for monitoring the chemical changes occurring in beer exposed to forced aging (at 45 deg. C for up to 18 days) is described. Both principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) were applied to the NMR spectra of beer recorded as a function of aging and an aging trend was observed. Inspection of PLS-DA loadings and peak integration revealed the importance of well known markers (e.g. 5-HMF) as well as of other compounds: amino acids, higher alcohols, organic acids, dextrins and some still unassigned spin systems. 2D correlation analysis enabled relevant compound variations to be confirmed and inter-compound correlations to be assessed, thus offering improved insight into the chemical aspects of beer aging. Highlights: {center_dot} Use of NMR metabonomics for monitoring the chemical changes occurring in beer exposed to forced aging. {center_dot} Compositional variations evaluated by principal component analysis and partial least squares-discriminant analysis. {center_dot} Results reveal importance of known markers and other compounds: amino and organic acids, higher alcohols, dextrins. {center_dot} 2D correlation analysis reveals inter-compound relationships, offering insight into beer aging chemistry. - Abstract: This paper describes the use of nuclear magnetic resonance (NMR) spectroscopy, in tandem with multivariate analysis (MVA), for monitoring the chemical changes occurring in a lager beer exposed to forced aging (at 45 deg. C for up to 18 days). To evaluate the resulting compositional variations, both principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) were applied to the NMR spectra of beer recorded as a function of aging and a clear aging trend was observed. Inspection of PLS-DA loadings and peak integration enabled the changing compounds to be identified, revealing the importance of well known

  18. Practical applications of age-dependent reliability models and analysis of operational data

    Energy Technology Data Exchange (ETDEWEB)

    Lannoy, A.; Nitoi, M.; Backstrom, O.; Burgazzi, L.; Couallier, V.; Nikulin, M.; Derode, A.; Rodionov, A.; Atwood, C.; Fradet, F.; Antonov, A.; Berezhnoy, A.; Choi, S.Y.; Starr, F.; Dawson, J.; Palmen, H.; Clerjaud, L

    2005-07-01

    The purpose of the workshop was to present the experience of practical application of time-dependent reliability models. The program of the workshop comprises the following sessions: -) aging management and aging PSA (Probabilistic Safety Assessment), -) modeling, -) operation experience, and -) accelerating aging tests. In order to introduce time aging effect of particular component to the PSA model, it has been proposed to use the constant unavailability values on the short period of time (one year for example) calculated on the basis of age-dependent reliability models. As for modeling, it appears that the problem of too detailed statistical models for application is the lack of data for required parameters. As for operating experience, several methods of operating experience analysis have been presented (algorithms for reliability data elaboration and statistical identification of aging trend). As for accelerated aging tests, it is demonstrated that a combination of operating experience analysis with the results of accelerated aging tests of naturally aged equipment could provide a good basis for continuous operation of instrumentation and control systems.

  19. Experimental and computational analysis of composite ankle-foot orthosis.

    Science.gov (United States)

    Zou, Dequan; He, Tao; Dailey, Michael; Smith, Kirk E; Silva, Matthew J; Sinacore, David R; Mueller, Michael J; Hastings, Mary K

    2014-01-01

    Carbon fiber (CF) ankle-foot orthoses (AFOs) can improve gait by increasing ankle plantar-flexor power and improving plantar-flexor ankle joint moment and energy efficiency compared with posterior leaf spring AFOs made of thermoplastic. However, fabricating a CF AFO to optimize the performance of the individual user may require multiple AFOs and expensive fabrication costs. Finite element analysis (FEA) models were developed to predict the mechanical behavior of AFOs in this study. Three AFOs, two made of CF composite material and one made of thermoplastic material, were fabricated and then mechanically tested to produce force-displacement data. The FEA models were validated by comparing model predictions with mechanical testing data performed under the same loading and boundary conditions. The actual mechanical testing demonstrated that CF performs better than thermoplastic. The simulation results showed that FEA models produced accurate predictions for both types of orthoses. The relative error of the energy return ratio predicted by the CF AFO FEA model developed in this study is less than 3%. We conclude that highly accurate FEA models will allow orthotists to improve CF AFO fabrication without wasting resources (time and money) on trial and error fabrications that are expensive and do not consistently improve AFO and user performance.

  20. Experimental and computational analysis of composite ankle-foot orthosis

    Directory of Open Access Journals (Sweden)

    Dequan Zou, DSc

    2015-03-01

    Full Text Available Carbon fiber (CF ankle-foot orthoses (AFOs can improve gait by increasing ankle plantar-flexor power and improving plantar-flexor ankle joint moment and energy efficiency compared with posterior leaf spring AFOs made of thermoplastic. However, fabricating a CF AFO to optimize the performance of the individual user may require multiple AFOs and expensive fabrication costs. Finite element analysis (FEA models were developed to predict the mechanical behavior of AFOs in this study. Three AFOs, two made of CF composite material and one made of thermoplastic material, were fabricated and then mechanically tested to produce force-displacement data. The FEA models were validated by comparing model predictions with mechanical testing data performed under the same loading and boundary conditions. The actual mechanical testing demonstrated that CF performs better than thermoplastic. The simulation results showed that FEA models produced accurate predictions for both types of orthoses. The relative error of the energy return ratio predicted by the CF AFO FEA model developed in this study is less than 3%. We conclude that highly accurate FEA models will allow orthotists to improve CF AFO fabrication without wasting resources (time and money on trial and error fabrications that are expensive and do not consistently improve AFO and user performance.

  1. Age estimation using pulp/tooth area ratio: A digital image analysis

    Directory of Open Access Journals (Sweden)

    Sasidhar Singaraju

    2009-01-01

    Full Text Available Age is one of the essential factors in establishing the identity of the person. Estimation of the human age is a procedure adopted by anthropologists, archeologists, and forensic scientists. Inspection of radiographs and subsequent comparison with radiographic images, in charts yield ′maturity scores′ that help us to assess the age of an individual. Alternative approaches based on digitalization of panoramic radiographs and their computerized storage have recently become available that exploit image analysis to obtain nondestructive metric measurements of both pulp chambers and teeth, which can be used to assess the age of an individual. The purpose of the present study was to present a method for assessing the chronological age based on the relationship between age and measurement of the pulp/tooth area ratio on single-rooted teeth, using orthopantomographs and a computer-aided drafting program AutoCAD 2000.

  2. The application of analysis of variance (ANOVA) to different experimental designs in optometry.

    Science.gov (United States)

    Armstrong, R A; Eperjesi, F; Gilmartin, B

    2002-05-01

    Analysis of variance (ANOVA) is the most efficient method available for the analysis of experimental data. Analysis of variance is a method of considerable complexity and subtlety, with many different variations, each of which applies in a particular experimental context. Hence, it is possible to apply the wrong type of ANOVA to data and, therefore, to draw an erroneous conclusion from an experiment. This article reviews the types of ANOVA most likely to arise in clinical experiments in optometry including the one-way ANOVA ('fixed' and 'random effect' models), two-way ANOVA in randomised blocks, three-way ANOVA, and factorial experimental designs (including the varieties known as 'split-plot' and 'repeated measures'). For each ANOVA, the appropriate experimental design is described, a statistical model is formulated, and the advantages and limitations of each type of design discussed. In addition, the problems of non-conformity to the statistical model and determination of the number of replications are considered.

  3. Plutonium Worlds. Fast Breeders, Systems Analysis and Computer Simulation in the Age of Hypotheticality

    Directory of Open Access Journals (Sweden)

    Sebastian Vehlken

    2014-09-01

    Full Text Available This article examines the media history of one of the hallmark civil nuclear energy programs in Western Germany – the development of Liquid Metal Fast Breeder Reactor (LMFBR technology. Promoted as a kind of perpetuum mobile of the Atomic Age, the "German Manhattan Project" not only imported big science thinking. In its context, nuclear technology was also put forth as an avantgarde of scientific inquiry, dealing with the most complex and critical technological endeavors. In the face of the risks of nuclear technology, German physicist Wolf Häfele thus announced a novel epistemology of "hypotheticality". In a context where traditional experimental engineering strategies became inappropiate, he called for the application of advanced media technologies: Computer Simulations (CS and Systems Analysis (SA generated computerized spaces for the production of knowledge. In the course of the German Fast Breeder program, such methods had a twofold impact. One the one hand, Häfele emphazised – as the "father of the German Fast Breeder" – the utilization of CS for the actual planning and construction of the novel reactor type. On the other, namely as the director of the department of Energy Systems at the International Institute for Applied Systems Analysis (IIASA, Häfele advised SA-based projections of energy consumption. These computerized scenarios provided the rationale for the conception of Fast Breeder programs as viable and necessary alternative energy sources in the first place. By focusing on the role of the involved CS techniques, the paper thus investigates the intertwined systems thinking of nuclear facilities’s planning and construction and the design of large-scale energy consumption and production scenarios in the 1970s and 1980s, as well as their conceptual afterlives in our contemporary era of computer simulation.

  4. 40 CFR 158.2171 - Experimental use permit microbial pesticides product analysis data requirements table.

    Science.gov (United States)

    2010-07-01

    ... pesticides product analysis data requirements table. 158.2171 Section 158.2171 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Microbial Pesticides § 158.2171 Experimental use permit microbial pesticides product analysis data requirements...

  5. Experimental analysis of the steady-state behaviour of beam systems with discontinuous support

    NARCIS (Netherlands)

    Vorst, E.L.B. van de; Campen, D.H. van; Kraker, A. de; Fey, R.H.B.

    1996-01-01

    This paper deals with the experimental analysis of the long-term behaviour of periodically excited linear beams supported by a one-sided spring or an elastic stop. Numerical analysis of the beams showed subharmonic, quasi-periodic and chaotic behaviour. Furthermore, in the beam system with the one-s

  6. Experimental Tityus serrulatus scorpion envenomation: age- and sex-related differences in symptoms and mortality in mice

    Directory of Open Access Journals (Sweden)

    Pucca MB

    2011-01-01

    Full Text Available Among the various methods for evaluating animal venom toxicity, the calculation of the median lethal dose (LD50 is the most widely used. Although different protocols can be used to calculate the LD50, the source of the venom and the method of extraction, as well as the strain, age, and sex of the animal model employed, should be taken into consideration. The objective of the present study was to evaluate the influence of sex and age on the toxicity of Tityus serrulatus scorpion venom in Swiss mice. Although the symptoms of envenomation were similar in male and female animals, female mice proved to be more resistant to the venom. In females, age had no impact on the susceptibility to scorpion envenomation. Male mice were more sensitive to T. serrulatus venom. Moreover, in males, age was an important parameter since sensitivity to the venom increased with age.

  7. Analysis of human immune responses in quasi-experimental settings: tutorial in biostatistics

    Directory of Open Access Journals (Sweden)

    Sarkar Rajiv

    2012-01-01

    Full Text Available Abstract Background Human immunology is a growing field of research in which experimental, clinical, and analytical methods of many life science disciplines are utilized. Classic epidemiological study designs, including observational longitudinal birth cohort studies, offer strong potential for gaining new knowledge and insights into immune response to pathogens in humans. However, rigorous discussion of methodological issues related to designs and statistical analysis that are appropriate for longitudinal studies is lacking. Methods In this communication we address key questions of quality and validity of traditional and recently developed statistical tools applied to measures of immune responses. For this purpose we use data on humoral immune response (IR associated with the first cryptosporidial diarrhea in a birth cohort of children residing in an urban slum in south India. The main objective is to detect the difference and derive inferences for a change in IR measured at two time points, before (pre and after (post an event of interest. We illustrate the use and interpretation of analytical and data visualization techniques including generalized linear and additive models, data-driven smoothing, and combinations of box-, scatter-, and needle-plots. Results We provide step-by-step instructions for conducting a thorough and relatively simple analytical investigation, describe the challenges and pitfalls, and offer practical solutions for comprehensive examination of data. We illustrate how the assumption of time irrelevance can be handled in a study with a pre-post design. We demonstrate how one can study the dynamics of IR in humans by considering the timing of response following an event of interest and seasonal fluctuation of exposure by proper alignment of time of measurements. This alignment of calendar time of measurements and a child's age at the event of interest allows us to explore interactions between IR, seasonal exposures and age

  8. Highly Efficient Design-of-Experiments Methods for Combining CFD Analysis and Experimental Data

    Science.gov (United States)

    Anderson, Bernhard H.; Haller, Harold S.

    2009-01-01

    It is the purpose of this study to examine the impact of "highly efficient" Design-of-Experiments (DOE) methods for combining sets of CFD generated analysis data with smaller sets of Experimental test data in order to accurately predict performance results where experimental test data were not obtained. The study examines the impact of micro-ramp flow control on the shock wave boundary layer (SWBL) interaction where a complete paired set of data exist from both CFD analysis and Experimental measurements By combining the complete set of CFD analysis data composed of fifteen (15) cases with a smaller subset of experimental test data containing four/five (4/5) cases, compound data sets (CFD/EXP) were generated which allows the prediction of the complete set of Experimental results No statistical difference were found to exist between the combined (CFD/EXP) generated data sets and the complete Experimental data set composed of fifteen (15) cases. The same optimal micro-ramp configuration was obtained using the (CFD/EXP) generated data as obtained with the complete set of Experimental data, and the DOE response surfaces generated by the two data sets were also not statistically different.

  9. Androgen deficiency in the aging male and chronic prostatitis: clinical and diagnostic comparative analysis

    Directory of Open Access Journals (Sweden)

    Spirin Р.V.

    2013-03-01

    Full Text Available The research goal is to study probability, period of development and characteristics of a clinical course of chronic prostatitis against the background of androgen deficiency in the aging male. Materials and methods: The Aging Male Symptoms (AMS rating scale has been applied for androgen deficiency evaluation and the International Prostate Symptom Score (IPSS — for chronic prostatitis evaluation. 57 men with chronic prostatitis in combination with androgen deficiency in the aging male have been examined. Results: It has been concluded that the development of chronic prostatitis against the background of androgen deficiency in the aging male occurs in a shorter time period and about 1.5 times more frequently compared to androgen deficiency in the aging male at the background of chronic prostatitis. The analysis of time periods between the onset of chronic prostatitis symptoms against the background of androgen deficiency in the aging male and androgen deficiency in the aging male symptoms against the background of chronic prostatitis showed that androgen deficiency in the aging male symptoms have been revealed 1-2 years earlier than the onset of chronic prostatitis. The development of androgen deficiency in the aging male against the background of chronic prostatitis has showed a backward tendency. Signs of chronic prostatitis have been more frequently occurred in a period of four-five years earlier the androgen deficiency in the aging male development. Conclusion: The risk of development of chronic prostatitis against the background of androgen deficiency in the aging male during the next two years is actually four times higher in comparison with the development of androgen deficiency in the aging male against the background of chronic prostatitis. According to the International Prostate Symptom Score (IPSS, patients with chronic prostatitis in combination with androgen deficiency in the aging male showed higher degree of severity than

  10. Region-specific changes of cerebral white matter during normal aging: a diffusion-tensor analysis.

    Science.gov (United States)

    Yoon, Bora; Shim, Yong-Soo; Lee, Kwang-Soo; Shon, Young-Min; Yang, Dong-Won

    2008-01-01

    With aging, the human brain tissue undergoes degeneration and a decline in cognitive function. Diffusion tensor imaging (DTI) is a sensitive method for detecting microstructural changes of the brain white matter (WM). We examined the age-dependent, region-specific, changing patterns in microstructures of the brain. This was preformed by DTI analysis of 58 healthy volunteers from Korea. The fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured for each region of interest (ROI) in 22 areas. The FA and ADC values of all 22 ROIs were, respectively, compared among the age groups, by linear regression analysis and analysis of variance. With aging, the ADC values tended to increase and the FA values tended to decrease. Patterns of regional changes of the FA were divided into three subgroups. The cingulum was affected earliest with aging and the age-related WM changes show an anterior to posterior gradient acceleration throughout the decades tested. This study suggests that DTI is sensitive enough a diagnostic tool to detect subtle microstructural changes. These results show that the WM has a region-specific vulnerability to the aging process.

  11. Probabilistic fracture mechanics analysis of thermally aged nuclear piping in a pressurized water reactor

    Energy Technology Data Exchange (ETDEWEB)

    Li, Shuxiao; Zhang, Hailong; Li, Shilei; Wang, Yanli [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China); Xue, Fei [Suzhou Nuclear Power Research Institute, Suzhou 215004 (China); Wang, Xitao, E-mail: xtwang@ustb.edu.cn [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China)

    2013-12-15

    Highlights: • Thermal aging embrittlement was considered in the PFM analysis of nuclear pipe. • Predicting program for pipe failure probability was developed based on thermal aging. • Cumulative failure probability is significantly affected by fracture toughness. • Cumulative failure probability is slightly affected by fatigue crack growth rate. • Tensile strength increase due to thermal aging slightly reduces pipe failure risk. - Abstract: A predicting program for pipe break probability based on thermal aging embrittlement was developed. In order for life prediction, evolutions of fracture toughness and tensile strength were estimated for a Z3CN20-09M piping steel using the Argonne National Laboratory (ANL) procedure. To understand the influence of thermal aging on failure probability, different evolutions of fracture toughness, tensile strength and fatigue crack growth rate were employed in the prediction of cumulative failure probability. The results show that the cumulative failure probability for 40-year thermal aging increases by almost four times compared to without consideration of fracture toughness degradation. The cumulative failure probability is slightly affected by fatigue crack growth rate. The increase of tensile strength due to thermal aging reduces the risk of pipe failure. This work demonstrates that the degradation of fracture toughness due to thermal aging should be fully considered in the probabilistic fracture mechanics analysis of nuclear pressure pipes.

  12. Global genome splicing analysis reveals an increased number of alternatively spliced genes with aging.

    Science.gov (United States)

    Rodríguez, Sofía A; Grochová, Diana; McKenna, Tomás; Borate, Bhavesh; Trivedi, Niraj S; Erdos, Michael R; Eriksson, Maria

    2016-04-01

    Alternative splicing (AS) is a key regulatory mechanism for the development of different tissues; however, not much is known about changes to alternative splicing during aging. Splicing events may become more frequent and widespread genome-wide as tissues age and the splicing machinery stringency decreases. Using skin, skeletal muscle, bone, thymus, and white adipose tissue from wild-type C57BL6/J male mice (4 and 18 months old), we examined the effect of age on splicing by AS analysis of the differential exon usage of the genome. The results identified a considerable number of AS genes in skeletal muscle, thymus, bone, and white adipose tissue between the different age groups (ranging from 27 to 246 AS genes corresponding to 0.3-3.2% of the total number of genes analyzed). For skin, skeletal muscle, and bone, we included a later age group (28 months old) that showed that the number of alternatively spliced genes increased with age in all three tissues (P aging disease Hutchinson-Gilford progeria syndrome was performed. The results show that expression of the mutant protein, progerin, is associated with an impaired developmental splicing. As progerin accumulates, the number of genes with AS increases compared to in wild-type skin. Our results indicate the existence of a mechanism for increased AS during aging in several tissues, emphasizing that AS has a more important role in the aging process than previously known.

  13. Age-Specific Gene Expression Profiles of Rhesus Monkey Ovaries Detected by Microarray Analysis

    Directory of Open Access Journals (Sweden)

    Hengxi Wei

    2015-01-01

    Full Text Available The biological function of human ovaries declines with age. To identify the potential molecular changes in ovarian aging, we performed genome-wide gene expression analysis by microarray of ovaries from young, middle-aged, and old rhesus monkeys. Microarray data was validated by quantitative real-time PCR. Results showed that a total of 503 (60 upregulated, 443 downregulated and 84 (downregulated genes were differentially expressed in old ovaries compared to young and middle-aged groups, respectively. No difference in gene expression was found between middle-aged and young groups. Differentially expressed genes were mainly enriched in cell and organelle, cellular and physiological process, binding, and catalytic activity. These genes were primarily associated with KEGG pathways of cell cycle, DNA replication and repair, oocyte meiosis and maturation, MAPK, TGF-beta, and p53 signaling pathway. Genes upregulated were involved in aging, defense response, oxidation reduction, and negative regulation of cellular process; genes downregulated have functions in reproduction, cell cycle, DNA and RNA process, macromolecular complex assembly, and positive regulation of macromolecule metabolic process. These findings show that monkey ovary undergoes substantial change in global transcription with age. Gene expression profiles are useful in understanding the mechanisms underlying ovarian aging and age-associated infertility in primates.

  14. Analysis of the current situation regarding the aging rural population in China and proposed countermeasures.

    Science.gov (United States)

    Qu, Bo; Li, Xiyuan; Liu, Jie; Mao, Jiawen

    2012-06-01

    China has become a country with an aging population. Compared with the aged in urban areas, the aged in rural areas have low income and are subject to social security deficiencies; the oldest among them are the most vulnerable group. If an effective mechanism for handling health risk is not available, the poor health of the rural elderly will cause an increase in their poverty level, which in turn will cause their health to become worse. Therefore, it is essential to analyze the current situation regarding rural population aging in China and to develop countermeasures. Data from 4 national health services surveys were used to analyze the differences between urban and rural populations. The results of the analysis revealed that the aged population in rural areas has poor health; economic security for the aged population is insufficient; and resources for the aged are lacking in rural areas. The Chinese government should improve medicare for the aged in rural areas, and establish a medical treatment subsidy system and a medical support system for the aged in rural areas.

  15. Assessment of Cable Aging Equipment, Status of Acquired Materials, and Experimental Matrix at the Pacific Northwest National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Fifield, Leonard S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Westman, Matthew P. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Zwoster, Andy [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Schwenzer, Birgit [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-03-30

    The need for increased understanding of the aging and degradation behavior for polymer components of nuclear power plant electrical cables is described in this report. The highest priority materials for study and the resources available at PNNL for these studies are also described. The anticipated outcomes of the PNNL work described are : improved understanding of appropriate accelerated aging conditions, improved knowledge of correlation between observable aging indicators and cable condition in support of advanced non-destructive evaluation methods, and practical knowledge of condition-based cable lifetime prediction.

  16. Analysis of experimental series of plutonium nitrate in aqueous solution and their correlation coefficients

    CERN Document Server

    Kilger, Robert; Stuke, Maik

    2016-01-01

    In this work we performed a detailed analysis on the calculation of 43 critical experiments from 6 experimental series all describing plutonium nitrate in aqueous solution contained in metal spheres. The underlying experimental data is taken from the handbook of the International Criticality Safety Benchmark Evaluation Project (ICSBEP) Working Group. We present our modeling assumptions which were derived from the interpretation of the experimental data and discuss the resulting sensitivity analysis. Although the experiments share some components, the derived correlation coefficients are for many cases statistically not significant. Comparing our findings for the correlation coefficients with available data from the DICE Database we find an agreement for the correlation coefficients due to nuclear data. We also compare our results for the correlation coefficients due to experimental uncertainty. Our findings indicate that for the reliable Determination of correlation coefficients a detailed study of the underl...

  17. 40 CFR Appendix Ix to Part 86 - Experimentally Determining the R-Factor for Bench Aging Durability Procedures

    Science.gov (United States)

    2010-07-01

    ... in § 86.1826-08(d)(4). 3. Plot emissions (or catalyst inefficiency) versus aging time for each.... Plot the natural log (ln) of the slope of each best-fit line (determined in step 4) along the...

  18. Cluster Analysis of Physical and Cognitive Ageing Patterns in Older People from Shanghai

    Directory of Open Access Journals (Sweden)

    Stephan Bandelow

    2016-02-01

    Full Text Available This study investigated the relationship between education, cognitive and physical function in older age, and their respective impacts on activities of daily living (ADL. Data on 148 older participants from a community-based sample recruited in Shanghai, China, included the following measures: age, education, ADL, grip strength, balance, gait speed, global cognition and verbal memory. The majority of participants in the present cohort were cognitively and physically healthy and reported no problems with ADL. Twenty-eight percent of participants needed help with ADL, with the majority of this group being over 80 years of age. Significant predictors of reductions in functional independence included age, balance, global cognitive function (MMSE and the gait measures. Cluster analysis revealed a protective effect of education on cognitive function that did not appear to extend to physical function. Consistency of such phenotypes of ageing clusters in other cohort studies may provide helpful models for dementia and frailty prevention measures.

  19. Newly arrived elderly immigrants: a concept analysis of "aging out of place".

    Science.gov (United States)

    Sadarangani, Tina R; Jun, Jin

    2015-03-01

    Newcomer elderly immigrants, defined as adults older than the age of 65 who have arrived in the United States in the last 10 years, represent a growing sector of the American population. Newcomers who experience limited English proficiency, financial strain, and acculturative stress are at considerable risk of developing poor health outcomes. Nursing's focus on healthy aging and aging in place has largely ignored the experiences of these older adults, who are said to be "aging out of place." This concept analysis uses Rodgers's evolutionary method to define "aging out of place" and illustrates why existing theories of elderly migration do not necessarily apply to this population. The challenge for nurses is incorporating the family, with whom conflict may arise, into the care of these elders. Community-based strategies that enable social integration and create a greater division of labor in the care of newcomer elders are called for.

  20. Experimental modal analysis on damage of skeleton in brake of airplane

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    The relation between damage and modal parameters of skeleton has been discussed and analysed.Some significant results for detecting damage have been obtained by using experimental data of ωdi and ζi· Then, the modal experiments of four type of skeleton have been performed, the modal bifurcation phenomenon is discovered. It follows that this method for studying skeleton damage is a very promising method through theoretical and experimental analysis.

  1. Statistical Approaches in Analysis of Variance: from Random Arrangements to Latin Square Experimental Design

    OpenAIRE

    2009-01-01

    Background: The choices of experimental design as well as of statisticalanalysis are of huge importance in field experiments. These are necessary tobe correctly in order to obtain the best possible precision of the results. Therandom arrangements, randomized blocks and Latin square designs werereviewed and analyzed from the statistical perspective of error analysis.Material and Method: Random arrangements, randomized block and Latinsquares experimental designs were used as field experiments. ...

  2. Experimental study and kinetic analysis of the oxidation of light hydrocarbons mixtures

    Energy Technology Data Exchange (ETDEWEB)

    Rota, R.; Bonini, F.; Morbidelli, M.; Carra, S. [Politecnico di Milano (Italy). Dipt. di Chimica Fisica Applicata

    1996-07-01

    The combustion of various C{sup 1}-C{sub 2} hydrocarbon mixtures has been experimentally investigated in a continuous perfectly stirred reactor, in a temperature range from 1,000 to 1,300 K, and at stoichiometric ratio values between 0.5 and 1.5. The concentration values of several molecular species have been measured by GC analysis. The data obtained have been compared with the predictions of two different detailed kinetic models; both fail to predict the experimental trends in various situations. This leads to the conclusion that experimental data based on mixtures of hydrocarbons must be obtained to validate detailed kinetic mechanisms.

  3. Experimental spectra analysis in THM with the help of simulation based on Geant4 framework

    CERN Document Server

    Li, Chengbo; Zhou, Shuhua; Fu, Yuanyong; Zhou, Jing; Meng, Qiuying; Jiang, Zongjun; Wang, Xiaolian

    2014-01-01

    The Coulomb barrier and electron screening cause difficulties in directly measuring nuclear reaction cross sections of charged particles in astrophysical energies. The Trojan-horse method has been introduced to solve the difficulties as a powerful indirect tool. In order to understand experimental spectra better, Geant4 is employed to simulate the method for the first time. Validity and reliability of the simulation are examined by comparing the experimental data with simulated results. The Geant4 simulation can give useful information to understand the experimental spectra better in data analysis and is beneficial to the design for future related experiments.

  4. Transcriptional analysis reveals gender-specific changes in the aging of the human immune system.

    Science.gov (United States)

    Marttila, Saara; Jylhävä, Juulia; Nevalainen, Tapio; Nykter, Matti; Jylhä, Marja; Hervonen, Antti; Tserel, Liina; Peterson, Pärt; Hurme, Mikko

    2013-01-01

    Aging and gender have a strong influence on the functional capacity of the immune system. In general, the immune response in females is stronger than that in males, but there is scant information about the effect of aging on the gender difference in the immune response. To address this question, we performed a transcriptomic analysis of peripheral blood mononuclear cells derived from elderly individuals (nonagenarians, n = 146) and young controls (aged 19-30 years, n = 30). When compared to young controls, we found 339 and 248 genes that were differentially expressed (p1.5 or human immune system are significantly different in males and females.

  5. Velo and REXAN - Integrated Data Management and High Speed Analysis for Experimental Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Kleese van Dam, Kerstin; Carson, James P.; Corrigan, Abigail L.; Einstein, Daniel R.; Guillen, Zoe C.; Heath, Brandi S.; Kuprat, Andrew P.; Lanekoff, Ingela T.; Lansing, Carina S.; Laskin, Julia; Li, Dongsheng; Liu, Yan; Marshall, Matthew J.; Miller, Erin A.; Orr, Galya; Pinheiro da Silva, Paulo; Ryu, Seun; Szymanski, Craig J.; Thomas, Mathew

    2013-01-10

    The Chemical Imaging Initiative at the Pacific Northwest National Laboratory (PNNL) is creating a ‘Rapid Experimental Analysis’ (REXAN) Framework, based on the concept of reusable component libraries. REXAN allows developers to quickly compose and customize high throughput analysis pipelines for a range of experiments, as well as supporting the creation of multi-modal analysis pipelines. In addition, PNNL has coupled REXAN with its collaborative data management and analysis environment Velo to create an easy to use data management and analysis environments for experimental facilities. This paper will discuss the benefits of Velo and REXAN in the context of three examples: PNNL High Resolution Mass Spectrometry - reducing analysis times from hours to seconds, and enabling the analysis of much larger data samples (100KB to 40GB) at the same time · ALS X-Ray tomography - reducing analysis times of combined STXM and EM data collected at the ALS from weeks to minutes, decreasing manual work and increasing data volumes that can be analysed in a single step ·Multi-modal nano-scale analysis of STXM and TEM data - providing a semi automated process for particle detection The creation of REXAN has significantly shortened the development time for these analysis pipelines. The integration of Velo and REXAN has significantly increased the scientific productivity of the instruments and their users by creating easy to use data management and analysis environments with greatly reduced analysis times and improved analysis capabilities.

  6. Analysis of the age of Panax ginseng based on telomere length and telomerase activity.

    Science.gov (United States)

    Liang, Jiabei; Jiang, Chao; Peng, Huasheng; Shi, Qinghua; Guo, Xiang; Yuan, Yuan; Huang, Luqi

    2015-01-23

    Ginseng, which is the root of Panax ginseng (Araliaceae), has been used in Oriental medicine as a stimulant and dietary supplement for more than 7,000 years. Older ginseng plants are substantially more medically potent, but ginseng age can be simulated using unscrupulous cultivation practices. Telomeres progressively shorten with each cell division until they reach a critical length, at which point cells enter replicative senescence. However, in some cells, telomerase maintains telomere length. In this study, to determine whether telomere length reflects ginseng age and which tissue is best for such an analysis, we examined telomerase activity in the main roots, leaves, stems, secondary roots and seeds of ginseng plants of known age. Telomere length in the main root (approximately 1 cm below the rhizome) was found to be the best indicator of age. Telomeric terminal restriction fragment (TRF) lengths, which are indicators of telomere length, were determined for the main roots of plants of different ages through Southern hybridization analysis. Telomere length was shown to be positively correlated with plant age, and a simple mathematical model was formulated to describe the relationship between telomere length and age for P. ginseng.

  7. Computer-assisted sperm analysis parameters in young fertile sperm donors and relationship with age.

    Science.gov (United States)

    Fréour, Thomas; Jean, Miguel; Mirallie, Sophie; Barriere, Paul

    2012-04-01

    Sperm parameter values have been shown to decline with age, according to conventional sperm analysis. However, the effect of age on sperm kinematic parameters has been rarely studied, especially in young fertile men. Here, we studied Computer-Assisted Sperm Analysis (CASA) parameters in a large cohort of men with proven fertility, in order to determine if there is a decline with age in this young fertile population. This retrospective analysis of CASA parameters was conducted on all donors included in the sperm donor programme in the Assisted Reproductive Techniques (ART) Centre of the University Hospital of Nantes between 2006 and 2009. Sperm concentration, motility, and kinetic parameters were recorded by a HTM-Ceros system and compared in 3 groups of sperm donors according to their age: donors were analyzed. Values for ALH, VCL, LIN, and STR significantly decreased with age. Sperm concentration, motile sperm proportion, and other kinetic parameters did not differ significantly among the groups. The use of CASA allowed the identification of ALH, VCL, LIN, and STR age-related decrease in young men with proven fertility.

  8. The incidence of cervical spondylosis decreases with aging in the elderly, and increases with aging in the young and adult population: a hospital-based clinical analysis

    Directory of Open Access Journals (Sweden)

    Wang C

    2016-01-01

    Full Text Available Chuanling Wang,1,* Fuming Tian,1,* Yingjun Zhou,2 Wenbo He,1 Zhiyou Cai1 1Department of Neurology, 2Physical Examination Center, Renmin Hospital, Hubei University of Medicine, Shiyan Renmin Hospital, Shiyan, Hubei Province, People’s Republic of China *These authors contributed equally to this work Background and purpose: Cervical spondylosis is well accepted as a common degenerative change in the cervical spine. Compelling evidence has shown that the incidence of cervical spondylosis increases with age. However, the relationship between age and the incidence of cervical spondylosis remains obscure. It is essential to note the relationship between age and the incidence of cervical spondylosis through more and more clinical data.Methods: In the case-controlled study reported here, retrospective clinical analysis of 1,276 cases of cervical spondylosis has been conducted. We analyzed the general clinical data, the relationship between age and the incidence of cervical spondylosis, and the relationship between age-related risk factors and the incidence of cervical spondylosis. A chi-square test was used to analyze the associations between different variables. Statistical significance was defined as a P-value of less than 0.05.Results: The imaging examination demonstrated the most prominent characteristic features of cervical spondylosis: bulge or herniation at C3-C4, C4-C5, and C5-C6. The incidence of cervical spondylosis increased with aging before age 50 years and decreased with aging after age 50 years, especially in the elderly after 60 years old. The occurrence rate of bulge or herniation at C3-C4, C4-C5, C5-C6, and C6-C7 increased with aging before age 50 years and decreased with aging after age 50 years, especially after 60 years. Moreover, the incidence of hyperosteogeny and spinal stenosis increased with aging before age 60 years and decreased with aging after age 60 years, although there was no obvious change in calcification. The age

  9. SPM analysis of cerebral blood flow changes related to age in patients with schizophrenia

    Energy Technology Data Exchange (ETDEWEB)

    Song, Ho Chun; Kim, Sung Wan; Lee, Byeong II; Min, Jung Joon; Bom, Hee Seung [Chonnam National University Medical School, Gwangju (Korea, Republic of)

    2007-07-01

    The goal of this study was to explore neural activities of schizophrenic patients related to current age including the age of onset and also we examined the correlation patterns between age and neural correlates. 21 patients with schizophrenia (female/male; 10/11, mean age; 36.1 11.2) participated in this study and all patients were evaluated by criteria of DSM-IV as a schizophrenia patient. Exclusion criteria included inability to give informed consent and a history of significant neurological illness. 99mTc-ECD brain perfusion SPECT images were obtained from 21 schizophrenic patients. Using SPM (statistical parametric mapping), all images were normalized to a SPECT template (MNI template) and then smoothed. We performed an ANCOVA analysis with current age (covariate variable) and the age of onset (nuisance variable). The correlation was analyzed into positive and negative patterns. Findings are reported as a Z scores with a significance threshold of p < 0.005 (uncorrected) and a minimum cluster size of 10. Significant difference was found between current age and premorbid age (p < 0.05). Cerebral regions that were positively correlated with current age were observed in the middle frontal gyrus and the superior frontal gyrus bilaterally, the left precentral gyrus (Brodmann's area; BA 9) and the right inferior frontal gyrus (BA 46). Also, in relation to negative correlations, there were many regions in the right posterior cingulate gyrus (BA 30) and the left cuneus (BA 30), middle temporal gyrus (BA 21) and superior temporal gyrus (BA 13, 39). Additionally, the occipital regions were found in the right cuneus (BA 18) including the right middle occipital gyrus (BA 18) and right lingual gyrus (BA 19). Age effect in schizophrenic patients was observed in the dorsolateral prefrontal cortex with positive correlation. We suggest that the dorsolateral prefrontal cortex activity which is important for cognitive task performance is related to an increase of patients

  10. Effect of thermal aging on the leak-before-break analysis of nuclear primary pipes

    Energy Technology Data Exchange (ETDEWEB)

    Lv, Xuming; Li, Shilei [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China); Wang, Xitao [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China); Collaborative Innovation Center of Steel Technology, University of Science and Technology Beijing, Beijing 100083 (China); Wang, Yanli [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China); Wang, Zhaoxi [CPI Nuclear Power Institute, 18 Xizhimen St., Beijing 100044 (China); Xue, Fei [Suzhou Nuclear Power Research Institute, Suzhou 215004 (China); Zhang, Hailong, E-mail: hlzhang@ustb.edu.cn [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China)

    2014-12-15

    Highlights: • Thermal aging embrittlement is considered in LBB assessment of nuclear pipe. • Effect of thermal aging on growth behavior of partial-through crack is not obvious. • Detectable leakage crack length of thermally aged material is slightly increased. • Critical crack length of thermally aged material is significantly reduced. • Ignorance of thermal aging produces less conservative LBB results. - Abstract: Three-dimensional finite element analysis (FEA) models were built for pipes with circumferential cracks and the effect of thermal aging embrittlement on the leak-before-break (LBB) behavior was analyzed according to the Level 2 and Level 3 safety assessments. The detectable leakage crack length obtained using the two-phase critical flow model and the critical crack length calculated by the J-integral stability assessment diagram method were carried out to assess the LBB behavior. The propagation behavior of partial-through circumferential cracks for both unaged and thermally aged materials was estimated by testing fatigue crack growth rate. The results show that the effect of thermal aging on detectable leakage crack length is not obvious, whereas the critical crack length after thermal aging significantly decreases due to degradation of fracture toughness. The increments of partial-through cracks are insignificant after 40 years of service. In the Level 2 and Level 3 safety assessments for nuclear piping, LBB is shown to have sufficient safety margins, while it is suggested to decrease in the case of thermal aging. This work demonstrates that less conservative LBB assessment results will be produced if thermal aging embrittlement in piping steels is not taken into consideration.

  11. Analysis and evaluation of facial expression and perceived age for designing automotive frontal views

    Science.gov (United States)

    Fujiwara, Takayuki; Kawasumi, Mikiko; Koshimizu, Hiroyasu

    2007-01-01

    We propose a method for quantifying the design of automotive frontal view based on the research on the human visual impression to the facial expression. We have researched to evaluate the automotive frontal face by using the facial words and the perceived age. Then we verified experimentally how effectively the line drawing image could work and coche-PICASSO image could be used for the image stimulation. As a result of this paper, a part of the facial words could be strongly correlated to both the facial expressions and the perceived age in the line drawing image. Besides, it was also known that the perceived age in the coche-PICASSO image was always younger than those of the line drawing image.

  12. Theoretical analysis and experimental research on port/starboard discrimination in towed line array

    Institute of Scientific and Technical Information of China (English)

    DU Xuanmin; ZHU Daizhu; ZHAO Rongrong; YAO Lan

    2001-01-01

    The theoretical analysis and experimental research on Port/Starboard (P/S) discrimination in towed line array are proposed. Two methods resolving the P/S ambiguity with hydrophone triplets are introduced. By processing experimental data, the theoretical analysis is verified. The processing algorithm is extended to broadband signal. The research results show that the method based on optimum beamforming with triplets can be used to remove the port/starboard ambiguity. Also because of the simplicity of the method, it is expected to be implemented in practical towed line array sonar.

  13. Experimental assessment of computer codes used for safety analysis of integral reactors

    Energy Technology Data Exchange (ETDEWEB)

    Falkov, A.A.; Kuul, V.S.; Samoilov, O.B. [OKB Mechanical Engineering, Nizhny Novgorod (Russian Federation)

    1995-09-01

    Peculiarities of integral reactor thermohydraulics in accidents are associated with presence of noncondensable gas in built-in pressurizer, absence of pumped ECCS, use of guard vessel for LOCAs localisation and passive RHRS through in-reactor HX`s. These features defined the main trends in experimental investigations and verification efforts for computer codes applied. The paper reviews briefly the performed experimental investigation of thermohydraulics of AST-500, VPBER600-type integral reactors. The characteristic of UROVEN/MB-3 code for LOCAs analysis in integral reactors and results of its verification are given. The assessment of RELAP5/mod3 applicability for accident analysis in integral reactor is presented.

  14. 3D strain map of axially loaded mouse tibia: a numerical analysis validated by experimental measurements.

    Science.gov (United States)

    Stadelmann, Vincent A; Hocke, Jean; Verhelle, Jensen; Forster, Vincent; Merlini, Francesco; Terrier, Alexandre; Pioletti, Dominique P

    2009-02-01

    A combined experimental/numerical study was performed to calculate the 3D octahedral shear strain map in a mouse tibia loaded axially. This study is motivated by the fact that the bone remodelling analysis, in this in vivo mouse model should be performed at the zone of highest mechanical stimulus to maximise the measured effects. Accordingly, it is proposed that quantification of bone remodelling should be performed at the tibial crest and at the distal diaphysis. The numerical model could also be used to furnish a more subtle analysis as a precise correlation between local strain and local biological response can be obtained with the experimentally validated numerical model.

  15. Age estimation in forensic sciences: Application of combined aspartic acid racemization and radiocarbon analysis

    Energy Technology Data Exchange (ETDEWEB)

    Alkass, K; Buchholz, B A; Ohtani, S; Yamamoto, T; Druid, H; Spalding, S L

    2009-11-02

    Age determination of unknown human bodies is important in the setting of a crime investigation or a mass disaster, since the age at death, birth date and year of death, as well as gender, can guide investigators to the correct identity among a large number of possible matches. Traditional morphological methods used by anthropologists to determine age are often imprecise, whereas chemical analysis of tooth dentin, such as aspartic acid racemization has shown reproducible and more precise results. In this paper we analyze teeth from Swedish individuals using both aspartic acid racemization and radiocarbon methodologies. The rationale behind using radiocarbon analysis is that above-ground testing of nuclear weapons during the cold war (1955-1963) caused an extreme increase in global levels of carbon-14 ({sup 14}C) which have been carefully recorded over time. Forty-four teeth from 41 individuals were analyzed using aspartic acid racemization analysis of tooth crown dentin or radiocarbon analysis of enamel and ten of these were split and subjected to both radiocarbon and racemization analysis. Combined analysis showed that the two methods correlated well (R2=0.66, p < 0.05). Radiocarbon analysis showed an excellent precision with an overall absolute error of 0.6 {+-} 04 years. Aspartic acid racemization also showed a good precision with an overall absolute error of 5.4 {+-} 4.2 years. Whereas radiocarbon analysis gives an estimated year of birth, racemization analysis indicates the chronological age of the individual at the time of death. We show how these methods in combination can also assist in the estimation of date of death of an unidentified victim. This strategy can be of significant assistance in forensic casework involving dead victim identification.

  16. Insulation Diagnosis of Service Aged XLPE Power Cables Using Statistical Analysis and Fuzzy Inference

    Institute of Scientific and Technical Information of China (English)

    LIU Fei; JIANG Pingkai; LEI Qingquan; ZHANG Li; SU Wenqun

    2013-01-01

    Cables that have been in service for over 20 years in Shanghai,a city with abundant surface water,failed more frequently and induced different cable accidents.This necessitates researches on the insulation aging state of cables working in special circumstances.We performed multi-parameter tests with samples from about 300 cable lines in Shanghai.The tests included water tree investigation,tensile test,dielectric spectroscopy test,thermogravimetric analysis (TGA),fourier transform infrared spectroscopy (FTIR),and electrical aging test.Then,we carried out regression analysis between every two test parameters.Moreover,through two-sample t-Test and analysis of variance (ANOVA) of each test parameter,we analyzed the influences of cable-laying method and sampling section on the degradation of cable insulation respectively.Furthermore,the test parameters which have strong correlation in the regression analysis or significant differences in the t-Test or ANOVA analysis were determined to be the ones identifying the XLPE cable insulation aging state.The thresholds for distinguishing insulation aging states had been also obtained with the aid of statistical analysis and fuzzy clustering.Based on the fuzzy inference,we established a cable insulation aging diagnosis model using the intensity transfer method.The results of regression analysis indicate that the degradation of cable insulation accelerates as the degree of in-service aging increases.This validates the rule that the increase of microscopic imperfections in solid material enhances the dielectric breakdown strength.The results of the two-sample t-Test and the ANOVA indicate that the direct-buried cables are more sensitive to insulation degradation than duct cables.This confirms that the tensile strength and breakdown strength are reliable functional parameters in cable insulation evaluations.A case study further indicates that the proposed diagnosis model based on the fuzzy inference can reflect the comprehensive

  17. Experimental evidence of ageing and slow restoration of the weak-contact configuration in tilted 3D granular packings

    Science.gov (United States)

    Kiesgen de Richter, S.; Zaitsev, V. Yu; Richard, P.; Delannay, R.; Le Caër, G.; Tournat, V.

    2010-11-01

    Granular packings slowly driven towards their instability threshold are studied using a digital imaging technique as well as a nonlinear acoustic method. The former method allows us to study grain rearrangements on the surface during the tilting and the latter enables us to selectively probe the modifications of the weak-contact fraction in the material bulk. Gradual ageing of both the surface activity and the weak-contact reconfigurations is observed as a result of repeated tilt cycles up to a given angle smaller than the angle of avalanche. For an aged configuration reached after several consecutive tilt cycles, abrupt resumption of the on-surface activity and of the weak-contact rearrangements occurs when the packing is subsequently inclined beyond the previous maximal tilting angle. This behavior is compared with literature results from numerical simulations of inclined 2D packings. It is also found that the aged weak-contact configurations exhibit spontaneous restoration towards the initial state if the packing remains at rest for tens of minutes. When the packing is titled forth and back between zero and near-critical angles, instead of ageing, the weak-contact configuration exhibits 'internal weak-contact avalanches' in the vicinity of both the near-critical and zero angles. By contrast, the stronger-contact skeleton remains stable.

  18. Age-related differences in sleep-based memory consolidation: A meta-analysis.

    Science.gov (United States)

    Gui, Wen-Jun; Li, Hui-Jie; Guo, Yu-Hua; Peng, Peng; Lei, Xu; Yu, Jing

    2017-02-02

    A period of post-learning sleep benefits memory consolidation compared with an equal-length wake interval. However, whether this sleep-based memory consolidation changes as a function of age remains controversial. Here we report a meta-analysis that investigates the age differences in the sleep-based memory consolidation in two types of memory: declarative memory and procedural memory. The meta-analysis included 22 comparisons of the performance between young adults (N =640) and older adults (N =529) on behavioral tasks measuring sleep-based memory consolidation. Our results showed a significant overall sleep-based beneficial effect in young adults but not in older adults. However, further analyses suggested that the age differences were mainly manifested in sleep-based declarative memory consolidation but not in procedural memory consolidation. We discussed the possible underlying mechanisms for the age-related degradation in sleep-based memory consolidation. Further research is needed to determine the crucial components for sleep-related memory consolidation in older adults such as age-related changes in neurobiological and cardiovascular functions, which may play an important role in this context and have the potential to delineate the interrelationships between age-related changes in sleep and memory.

  19. ANALYSIS OF RAILWAY USER TRAVEL BEHAVIOUR PATTERNS OF DIFFERENT AGE GROUPS

    Directory of Open Access Journals (Sweden)

    Takamasa AKIYAMA

    2009-01-01

    Full Text Available In recent years, there have been requirments for a transport environment that will foster the development of safe, comfortable townships. The study of urban activities amid an aging society and effective use of public transport modes in addressing environmental problems have become particularly important issues. This study analyzes travel behaviour patterns of varying age groups using urban railways in order to examine the relationship between urban public transport use and urban activities. specifically, it analyzes the composition of urban activity and travel behaviour patterns among urban railway users in the Keihanshin (Kyoto-Osaka-Kobe metropolitan area. This paper looks at urban activities within aging societies and identifies the differences in travel behaviour of railway users by separating them into young, middle aged and senior citizen age groups. Analysis makes particular use of the Railway station Database, which is a compilation of existing studies into attributes of railway stations and their surroundings, and results of person trip surveys. Rail use behaviour characteristics have been sorted by age group because mobility via urban railway systems is varied by age group. As a result, differences in railway usage patterns (travel objectives, distance and time, and number of transfers, etc. have been identified and so too have differences in urban activity patterns related to free activities (shopping, recreation. Furthermore, the study developed a travel behaviour pattern estimation model which is capable of categorizing specific transport behaviour patterns and estimating rail users and transport behaviour patterns from the relationship with areas surrounding railway stations to ensure future mobility by public transport for older age groups. The results make it possible to put forward proposals for urban rail services that will facilitate urban activities for the different age groups. Eventually, it will be possible to understand

  20. Black carbon ageing in the Canadian Centre for Climate modelling and analysis atmospheric general circulation model

    Directory of Open Access Journals (Sweden)

    B. Croft

    2005-01-01

    Full Text Available Black carbon (BC particles in the atmosphere have important impacts on climate. The amount of BC in the atmosphere must be carefully quantified to allow evaluation of the climate effects of this type of aerosol. In this study, we present the treatment of BC aerosol in the developmental version of the 4th generation Canadian Centre for Climate modelling and analysis (CCCma atmospheric general circulation model (AGCM. The focus of this work is on the conversion of insoluble BC to soluble/mixed BC by physical and chemical ageing. Physical processes include the condensation of sulphuric and nitric acid onto the BC aerosol, and coagulation with more soluble aerosols such as sulphates and nitrates. Chemical processes that may age the BC aerosol include the oxidation of organic coatings by ozone. Four separate parameterizations of the ageing process are compared to a control simulation that assumes no ageing occurs. These simulations use 1 an exponential decay with a fixed 24h half-life, 2 a condensation and coagulation scheme, 3 an oxidative scheme, and 4 a linear combination of the latter two ageing treatments. Global BC burdens are 2.15, 0.15, 0.11, 0.21, and 0.11TgC for the control run, and four ageing schemes, respectively. The BC lifetimes are 98.1, 6.6, 5.0, 9.5, and 4.9 days, respectively. The sensitivity of modelled BC burdens, and concentrations to the factor of two uncertainty in the emissions inventory is shown to be greater than the sensitivity to the parameterization used to represent the BC ageing, except for the oxidation based parameterization. A computationally efficient parameterization that represents the processes of condensation, coagulation, and oxidation is shown to simulate BC ageing well in the CCCma AGCM. As opposed to the globally fixed ageing time scale, this treatment of BC ageing is responsive to varying atmospheric composition.

  1. Cardiac autonomic changes in middle-aged women: identification based on principal component analysis.

    Science.gov (United States)

    Trevizani, Gabriela A; Nasario-Junior, Olivassé; Benchimol-Barbosa, Paulo R; Silva, Lilian P; Nadal, Jurandir

    2016-07-01

    The purpose of this study was to investigate the application of the principal component analysis (PCA) technique on power spectral density function (PSD) of consecutive normal RR intervals (iRR) aiming at assessing its ability to discriminate healthy women according to age groups: young group (20-25 year-old) and middle-aged group (40-60 year-old). Thirty healthy and non-smoking female volunteers were investigated (13 young [mean ± SD (median): 22·8 ± 0·9 years (23·0)] and 17 Middle-aged [51·7 ± 5·3 years (50·0)]). The iRR sequence was collected during ten minutes, breathing spontaneously, in supine position and in the morning, using a heart rate monitor. After selecting an iRR segment (5 min) with the smallest variance, an auto regressive model was used to estimate the PSD. Five principal component coefficients, extracted from PSD signals, were retained for analysis according to the Mahalanobis distance classifier. A threshold established by logistic regression allowed the separation of the groups with 100% specificity, 83·2% sensitivity and 93·3% total accuracy. The PCA appropriately classified two groups of women in relation to age (young and Middle-aged) based on PSD analysis of consecutive normal RR intervals.

  2. Forensic age estimation by the Schmeling method: computed tomography analysis of the medial clavicular epiphysis.

    Science.gov (United States)

    Ekizoglu, Oguzhan; Hocaoglu, Elif; Inci, Ercan; Sayin, Ibrahim; Solmaz, Dilek; Bilgili, Mustafa Gokhan; Can, Ismail Ozgur

    2015-01-01

    The variability of anthropometric measures, such as the degree of ossification, among societies should be taken into account when estimating age. The degree of ossification of the medial clavicle can be determined with thin-section computed tomography (CT), which is one of the methods recommended by the Study Group on Forensic Age Diagnostics of the German Association of Forensic Medicine. The purpose of this retrospective study was to investigate the applicability of thin-section CT analysis of the degree of ossification of the medial clavicle in a Turkish population. We evaluated the CT images (1-mm slice thickness) of 503 patients (362 male, 141 female; age, 10-35 years) using the Schmeling five-stage method. The Spearman's correlation analysis revealed a positive correlation between age and ossification stage in both male and female patients (total group: rho = 0.838, p < 0.001; male: rho = 0.831, p < 0.001; female: rho = 0.856, p < 0.001). The linear regression analysis results indicated that the ossification stage of the medial clavicle is a good predictor when estimating age (r (2) = 0.735 for all patients, 0.734 for male patients, 0.741 for female patients). Sex differences in ossification stages were observed only for stage 1 and 4 ossification. We believe that future research could expand the database on this topic and contribute to improvements in this measurement method.

  3. Quench front progression in a superheated porous medium: experimental analysis and model development

    Energy Technology Data Exchange (ETDEWEB)

    Bachrata, A.; Fichot, F.; Repetto, G., E-mail: andrea.bachrata@irsn.fr, E-mail: florian.fichot@irsn.fr, E-mail: georges.repetto@irsn.fr [Inst. de Radioprotection et de Surete Nucleaire, Cadarache (France); Quintard, M., E-mail: michel.quintard@imft.fr [Univ. de Toulouse, Toulouse (France); CNRS, IMFT, Toulouse (France); Fleurot, J. [Inst. de Radioprotection et de Surete Nucleaire, Cadarache (France)

    2011-07-01

    In case of severe accident in a nuclear reactor, the fuel rods may be highly damaged and oxidized and finally collapse to form a debris bed. Removal of decay heat from a debris bed is a challenging issue because of the difficulty for water to flow inside. Currently, IRSN has started experimental program PEARL with two experimental facilities PRELUDE and PEARL, to investigate the reflood process at high temperature, for various particle sizes. On the basis of PRELUDE experimental results, the thermal hydraulic features of the quench front have been analysed and the intensity of heat transfers was estimated. From a selection of experimental results, a reflooding model was improved and validated. The model is implemented in the code ICARE-CATHARE developed by IRSN which is used for severe accident reactor analysis. (author)

  4. 230Th/U ages Supporting Hanford Site‐Wide Probabilistic Seismic Hazard Analysis

    Science.gov (United States)

    Paces, James B.

    2014-01-01

    This product represents a USGS Administrative Report that discusses samples and methods used to conduct uranium-series isotope analyses and resulting ages and initial 234U/238U activity ratios of pedogenic cements developed in several different surfaces in the Hanford area middle to late Pleistocene. Samples were collected and dated to provide calibration of soil development in surface deposits that are being used in the Hanford Site-Wide probabilistic seismic hazard analysis conducted by AMEC. The report includes description of sample locations and physical characteristics, sample preparation, chemical processing and mass spectrometry, analytical results, and calculated ages for individual sites. Ages of innermost rinds on a number of samples from five sites in eastern Washington are consistent with a range of minimum depositional ages from 17 ka for cataclysmic flood deposits to greater than 500 ka for alluvium at several sites.

  5. 230Th/U ages Supporting Hanford Site-Wide Probabilistic Seismic Hazard Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Paces, James B. [U.S. Geological Survey

    2014-08-31

    This product represents a USGS Administrative Report that discusses samples and methods used to conduct uranium-series isotope analyses and resulting ages and initial 234U/238U activity ratios of pedogenic cements developed in several different surfaces in the Hanford area middle to late Pleistocene. Samples were collected and dated to provide calibration of soil development in surface deposits that are being used in the Hanford Site-Wide probabilistic seismic hazard analysis conducted by AMEC. The report includes description of sample locations and physical characteristics, sample preparation, chemical processing and mass spectrometry, analytical results, and calculated ages for individual sites. Ages of innermost rinds on a number of samples from five sites in eastern Washington are consistent with a range of minimum depositional ages from 17 ka for cataclysmic flood deposits to greater than 500 ka for alluvium at several sites.

  6. Dynamic Analysis of Rotating Shaft Subjects to Slant Crack with Experimentation and ANSYS Validation

    Directory of Open Access Journals (Sweden)

    Rushikesh V. Dhokate

    2014-09-01

    Full Text Available The paper contents the dynamic study of rotating shaft with slant crack on surface of shaft. Slant cracks are prepared artificially on surface of shaft with material EN8. In this study, crack location taken on shaft 150 mm from motor side and also for effective study healthy shaft of EN8 material is taken. Experimental results are taken with the help of FFT analyzer. Analysis is carried out from these results and finally these results are validated in FEA software i. e. ANSYS14 software. These validated results with graphs are explained in this paper. The experimentation is also done on healthy shaft of EN8 material for analysis. This paper mainly focused on validation of experimental results with ANSYS software.

  7. Evaluating the effect of aging on interference resolution with time-varying complex networks analysis

    Science.gov (United States)

    Ariza, Pedro; Solesio-Jofre, Elena; Martínez, Johann H.; Pineda-Pardo, José A.; Niso, Guiomar; Maestú, Fernando; Buldú, Javier M.

    2015-01-01

    In this study we used graph theory analysis to investigate age-related reorganization of functional networks during the active maintenance of information that is interrupted by external interference. Additionally, we sought to investigate network differences before and after averaging network parameters between both maintenance and interference windows. We compared young and older adults by measuring their magnetoencephalographic recordings during an interference-based working memory task restricted to successful recognitions. Data analysis focused on the topology/temporal evolution of functional networks during both the maintenance and interference windows. We observed that: (a) Older adults require higher synchronization between cortical brain sites in order to achieve a successful recognition, (b) The main differences between age groups arise during the interference window, (c) Older adults show reduced ability to reorganize network topology when interference is introduced, and (d) Averaging network parameters leads to a loss of sensitivity to detect age differences. PMID:26029079

  8. Evaluating the effect of ageing on interference resolution with time-varying complex networks analysis

    Directory of Open Access Journals (Sweden)

    Pedro eAriza

    2015-05-01

    Full Text Available In this study we used graph theory analysis to investigate age-related reorganization of functional networks during the active maintenance of information that is interrupted by external interference. Additionally, we sought to investigate network differences before and after averaging network parameters between both maintenance and interference windows. We compared young and older adults by measuring their magnetoencephalographic recordings during an interference-based working memory task restricted to successful recognitions. Data analysis focused on the topology/temporal evolution of functional networks during both the maintenance and interference windows. We observed that: a Older adults require higher synchronization between cortical brain sites in order to achieve a successful recognition, b The main differences between age groups arise during the interference window c Older adults show reduced ability to reorganize network topology when interference is introduced, and d Averaging network parameters leads to a loss of sensitivity to detect age differences.

  9. Patterns of cognitive performance in healthy ageing in Northern Portugal: a cross-sectional analysis.

    Directory of Open Access Journals (Sweden)

    Ana Cristina Paulo

    Full Text Available BACKGROUND: The Minho Integrative Neuroscience Database (MIND-Ageing project aims to identify predictors of healthy cognitive ageing, including socio-demographic factors. In this exploratory analysis we sought to establish baseline cohorts for longitudinal assessment of age-related changes in cognition. METHODS: The population sample (472 individuals was strictly a convenient one, but similar to the Portuguese population in the age profile. Participants older than 55 years of age were included if they did not present defined disabling pathologies or dementia. A standardized clinical interview was conducted to assess medical history and a battery of neuropsychological tests was administered to characterize global cognition (Mini Mental State Examination, memory and executive functions (Selective Reminding Test; Stroop Color and Word Test; and Block Design subtest of the Wechsler Adult Intelligence Scale. Cross-sectional analysis of the neuropsychological performance with individual characteristics such as age, gender, educational level and setting (retirement home, senior university, day care center or community, allowed the establishment of baseline clusters for subsequent longitudinal studies. RESULTS: Based on different socio-demographic characteristics, four main clusters that group distinctive patterns of cognitive performance were identified. The type of institution where the elders were sampled from, together with the level of formal education, were the major hierarchal factors for individual distribution in the four clusters. Of notice, education seems to delay the cognitive decline that is associated with age in all clusters. CONCLUSIONS: Social-inclusion/engagement and education seem to have a protective effect on mental ageing, although this effect may not be effective in the eldest elders.

  10. Application of ABCD Formalism in Theoretical and Experimental Analysis of Actively Modelocked Fiber Laser

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Time domain ABCD matrix formalism is a useful model for analyzing the characteristics of actively modelocked fiber laser. Based on this model and given more consideration on the influences of optical fiber dispersion and optical fiber nonlinearity, the laser characteristic of actively modelocked fiber laser is analyzed, and the comparision of the theoretical analysis results with experimental ones is given.

  11. The Etymology of Basic Concepts in the Experimental Analysis of Behavior

    Science.gov (United States)

    Dinsmoor, James A.

    2004-01-01

    The origins of many of the basic concepts used in the experimental analysis of behavior can be traced to Pavlov's (1927/1960) discussion of unconditional and conditional reflexes in the dog, but often with substantial changes in meaning (e.g., stimulus, response, and reinforcement). Other terms were added by Skinner (1938/1991) to describe his…

  12. Tableau tool for testing satisfiability in LTL: Implementation and experimental analysis

    DEFF Research Database (Denmark)

    Goranko, Valentin; Kyrilov, Angelo; Shkatov, Dmitry

    2010-01-01

    We report on the implementation and experimental analysis of an incremental multi-pass tableau-based procedure `a la Wolper for testing satisfiability in the linear time temporal logic LTL, based on a breadthfirst search strategy. We describe the implementation and discuss the performance of the ...

  13. Examination of a One-Trial Brief Experimental Analysis to Identify Reading Fluency Interventions

    Science.gov (United States)

    Andersen, Melissa N.; Daly, Edward J., III; Young, Nicholas D.

    2013-01-01

    This study sought to evaluate whether a one-trial brief experimental analysis (OTBEA) would reliably and validly identify effective treatments to improve oral reading fluency for 6 elementary school students referred for reading problems. An OTBEA was conducted with each participant to assess the effects of skill- and performance-based treatment…

  14. Reflections on the glass ceiling: women in the experimental analysis of behavior.

    Science.gov (United States)

    Odum, A L

    2000-01-01

    McSweeney and Swindell (1998) sought to determine whether men and women are treated equitably in the experimental analysis of behavior. They purported to show that women participate less in the Journal of the Experimental Analysis of Behavior than in similar journals and that the participation of women decreases with increases in selectivity. Their data were difficult to interpret, however, because they did not present the variability in the mean data drawn from different individuals over time. My analyses were not in accord with their conclusions. When the percentage of associate editors who are women was considered along with the mean percentages McSweeney and Swindell reported for other measures, participation did not systematically decrease with increases in selectivity in recent years. As quantified in terms of their number of publications in the Journal of the Experimental Analysis of Behavior, women who were editorial board members and associate editors were not more highly selected than their male counterparts. Finally, in the recent period from 1996 to 1998, although women submitted fewer manuscripts to the journal, rejection ratios did not differ for men and women. Efforts to increase the participation of women in the experimental analysis of behavior may best be directed toward recruitment and retention rather than some of the suggestions proposed by McSweeney and Swindell (1998), which could inadvertently create different standards for women's work.

  15. The Utility of a Brief Experimental Analysis for Problem Behavior Maintained by Escape from Demands

    Science.gov (United States)

    Schmidt, Jonathan D.; Shanholtzer, Alison; Mezhoudi, Nabil; Scherbak, Bailey; Kahng, SungWoo

    2014-01-01

    Brief experimental analysis (BEA) is a useful tool for quickly evaluating intervention strategies for individuals with academic deficits and minor behavior problems. However, there is a lack of research investigating BEA for intervention strategies with individuals who emit severe problem behavior to avoid academic demands. For the current study,…

  16. Experimental bifurcation analysis of an impact oscillator - Tuning a non-invasive control scheme

    DEFF Research Database (Denmark)

    Bureau, Emil; Schilder, Frank; Santos, Ilmar

    2013-01-01

    We investigate a non-invasive, locally stabilizing control scheme necessary for an experimental bifurcation analysis. Our test-rig comprises a harmonically forced impact oscillator with hardening spring nonlinearity controlled by electromagnetic actuators, and serves as a prototype for electromag...

  17. Reverse Schreinemakers Method for Experimental Analysis of Mixed-Solvent Electrolyte Systems

    DEFF Research Database (Denmark)

    Fosbøl, Philip Loldrup; Thomsen, Kaj; Stenby, Erling Halfdan

    2009-01-01

    from determining the composition of salt mixtures by pH titration are discussed, and the derived method significantly improves the obtained result from titration. Furthermore, the method reduces the required experimental work needed for analysis of phase composition. The method is applicable to multi...

  18. Alendronate Can Improve Bone Alterations in Experimental Diabetes by Preventing Antiosteogenic, Antichondrogenic, and Proadipocytic Effects of AGEs on Bone Marrow Progenitor Cells

    Science.gov (United States)

    2016-01-01

    Bisphosphonates such as alendronate are antiosteoporotic drugs that inhibit the activity of bone-resorbing osteoclasts and secondarily promote osteoblastic function. Diabetes increases bone-matrix-associated advanced glycation end products (AGEs) that impair bone marrow progenitor cell (BMPC) osteogenic potential and decrease bone quality. Here we investigated the in vitro effect of alendronate and/or AGEs on the osteoblastogenic, adipogenic, and chondrogenic potential of BMPC isolated from nondiabetic untreated rats. We also evaluated the in vivo effect of alendronate (administered orally to rats with insulin-deficient Diabetes) on long-bone microarchitecture and BMPC multilineage potential. In vitro, the osteogenesis (Runx2, alkaline phosphatase, type 1 collagen, and mineralization) and chondrogenesis (glycosaminoglycan production) of BMPC were both decreased by AGEs, while coincubation with alendronate prevented these effects. The adipogenesis of BMPC (PPARγ, intracellular triglycerides, and lipase) was increased by AGEs, and this was prevented by coincubation with alendronate. In vivo, experimental Diabetes (a) decreased femoral trabecular bone area, osteocyte density, and osteoclastic TRAP activity; (b) increased bone marrow adiposity; and (c) deregulated BMPC phenotypic potential (increasing adipogenesis and decreasing osteogenesis and chondrogenesis). Orally administered alendronate prevented all these Diabetes-induced effects on bone. Thus, alendronate could improve bone alterations in diabetic rats by preventing the antiosteogenic, antichondrogenic, and proadipocytic effects of AGEs on BMPC. PMID:27840829

  19. Alendronate Can Improve Bone Alterations in Experimental Diabetes by Preventing Antiosteogenic, Antichondrogenic, and Proadipocytic Effects of AGEs on Bone Marrow Progenitor Cells

    Directory of Open Access Journals (Sweden)

    Sara Rocío Chuguransky

    2016-01-01

    Full Text Available Bisphosphonates such as alendronate are antiosteoporotic drugs that inhibit the activity of bone-resorbing osteoclasts and secondarily promote osteoblastic function. Diabetes increases bone-matrix-associated advanced glycation end products (AGEs that impair bone marrow progenitor cell (BMPC osteogenic potential and decrease bone quality. Here we investigated the in vitro effect of alendronate and/or AGEs on the osteoblastogenic, adipogenic, and chondrogenic potential of BMPC isolated from nondiabetic untreated rats. We also evaluated the in vivo effect of alendronate (administered orally to rats with insulin-deficient Diabetes on long-bone microarchitecture and BMPC multilineage potential. In vitro, the osteogenesis (Runx2, alkaline phosphatase, type 1 collagen, and mineralization and chondrogenesis (glycosaminoglycan production of BMPC were both decreased by AGEs, while coincubation with alendronate prevented these effects. The adipogenesis of BMPC (PPARγ, intracellular triglycerides, and lipase was increased by AGEs, and this was prevented by coincubation with alendronate. In vivo, experimental Diabetes (a decreased femoral trabecular bone area, osteocyte density, and osteoclastic TRAP activity; (b increased bone marrow adiposity; and (c deregulated BMPC phenotypic potential (increasing adipogenesis and decreasing osteogenesis and chondrogenesis. Orally administered alendronate prevented all these Diabetes-induced effects on bone. Thus, alendronate could improve bone alterations in diabetic rats by preventing the antiosteogenic, antichondrogenic, and proadipocytic effects of AGEs on BMPC.

  20. Lithium Ion Batteries Ageing Analysis when used in a PV Power Plants

    DEFF Research Database (Denmark)

    Beltran, H.; Swierczynski, Maciej Jozef; Aparicio, N.;

    2012-01-01

    This paper analyzes the integration of lithium ion (Li-ion) batteries into large scale grid-connected PV plants. It performs a systematic analysis on both the operation improvement obtained by a PV+ES power plant and the ageing experienced by the Li-ion batteries used as Energy Storage (ES) system...

  1. Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index

    DEFF Research Database (Denmark)

    Minster, Ryan L; Sanders, Jason L; Singh, Jatinder;

    2015-01-01

    BACKGROUND: The Healthy Aging Index (HAI) is a tool for measuring the extent of health and disease across multiple systems. METHODS: We conducted a genome-wide association study and a genome-wide linkage analysis to map quantitative trait loci associated with the HAI and a modified HAI weighted...

  2. Digital Natives, Digital Immigrants: An Analysis of Age and ICT Competency in Teacher Education

    Science.gov (United States)

    Guo, Ruth Xiaoqing; Dobson, Teresa; Petrina, Stephen

    2008-01-01

    This article examines the intersection of age and ICT (information and communication technology) competency and critiques the "digital natives versus digital immigrants" argument proposed by Prensky (2001a, 2001b). Quantitative analysis was applied to a statistical data set collected in the context of a study with over 2,000 pre-service teachers…

  3. META-ANALYSIS OF THE LIFE STYLE FACTORS RELEVANT TO ENVIRONMENTAL HAZARDS FOR THE AGING POPULATION

    Science.gov (United States)

    The goal of this U.S. Environmental Protection Agency (EPA) study is to characterize activity patterns, physiological changes, and environmental exposures for the aging population. Meta analysis was performed on more than 2000 reviewed articles to evaluate the lifestyle factors ...

  4. Age estimation in the living: Transition analysis on developing third molars.

    Science.gov (United States)

    Tangmose, Sara; Thevissen, Patrick; Lynnerup, Niels; Willems, Guy; Boldsen, Jesper

    2015-12-01

    A radiographic assessment of third molar development is essential for differentiating between juveniles and adolescents in forensic age estimations. As the developmental stages of third molars are highly correlated, age estimates based on a combination of a full set of third molar scores are statistically complicated. Transition analysis (TA) is a statistical method developed for estimating age at death in skeletons, which combines several correlated developmental traits into one age estimate including a 95% prediction interval. The aim of this study was to evaluate the performance of TA in the living on a full set of third molar scores. A cross sectional sample of 854 panoramic radiographs, homogenously distributed by sex and age (15.0-24.0 years), were randomly split in two; a reference sample for obtaining age estimates including a 95% prediction interval according to TA; and a validation sample to test the age estimates against actual age. The mean inaccuracy of the age estimates was 1.82 years (±1.35) in males and 1.81 years (±1.44) in females. The mean bias was 0.55 years (±2.20) in males and 0.31 years (±2.30) in females. Of the actual ages, 93.7% of the males and 95.9% of the females (validation sample) fell within the 95% prediction interval. Moreover, at a sensitivity and specificity of 0.824 and 0.937 in males and 0.814 and 0.827 in females, TA performs well in differentiating between being a minor as opposed to an adult. Although accuracy does not outperform other methods, TA provides unbiased age estimates which minimize the risk of wrongly estimating minors as adults. Furthermore, when corrected ad hoc, TA produces appropriate prediction intervals. As TA allows expansion with additional traits, i.e. stages of development of the left hand-wrist and the clavicle, it has a great potential for future more accurate and reproducible age estimates, including an estimated probability of having attained the legal age limit of 18 years.

  5. An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging.

    Directory of Open Access Journals (Sweden)

    Tian Yuan

    2015-02-01

    Full Text Available Recent studies have demonstrated that the DNA methylome changes with age. This epigenetic drift may have deep implications for cellular differentiation and disease development. However, it remains unclear how much of this drift is functional or caused by underlying changes in cell subtype composition. Moreover, no study has yet comprehensively explored epigenetic drift at different genomic length scales and in relation to regulatory elements. Here we conduct an in-depth analysis of epigenetic drift in blood tissue. We demonstrate that most of the age-associated drift is independent of the increase in the granulocyte to lymphocyte ratio that accompanies aging and that enrichment of age-hypermethylated CpG islands increases upon adjustment for cellular composition. We further find that drift has only a minimal impact on in-cis gene expression, acting primarily to stabilize pre-existing baseline expression levels. By studying epigenetic drift at different genomic length scales, we demonstrate the existence of mega-base scale age-associated hypomethylated blocks, covering approximately 14% of the human genome, and which exhibit preferential hypomethylation in age-matched cancer tissue. Importantly, we demonstrate the feasibility of integrating Illumina 450k DNA methylation with ENCODE data to identify transcription factors with key roles in cellular development and aging. Specifically, we identify REST and regulatory factors of the histone methyltransferase MLL complex, whose function may be disrupted in aging. In summary, most of the epigenetic drift seen in blood is independent of changes in blood cell type composition, and exhibits patterns at different genomic length scales reminiscent of those seen in cancer. Integration of Illumina 450k with appropriate ENCODE data may represent a fruitful approach to identify transcription factors with key roles in aging and disease.

  6. Individual Subject Meta-Analysis of Parameters for Giardia duodenalis Shedding in Animal Experimental Models

    Directory of Open Access Journals (Sweden)

    A. D. Adell

    2014-01-01

    Full Text Available Giardia duodenalis is a zoonotic protozoan parasite with public health importance worldwide. While articles about animal model infectivity have been published for G. duodenalis, the studies have used diverse protocols and parameters to evaluate the infectivity of this protozoan parasite. Hence, the objectives of this study were to (1 conduct a meta-analysis of published literature for cyst shedding and diarrhea outcomes in animal models and (2 develop recommendations to help standardize experimental dose response studies. Results showed that, for the outcome of cyst shedding in faeces, the covariates of infective stage (cyst versus trophozoite, Giardia dose, and the interactions between doses and infective stage, as well as dose and species of experimental host, were all significant (P value ≤ 0.05. This study suggests inoculation of the experimental host with cysts rather than trophozoites and administration of higher doses of Giardia will most likely result in cyst shedding. Based on the results of this meta-analysis, the infective stage (cyst versus trophozoite, parasite dose, and the interactions between dose and infective stage, as well as dose and species of experimental host, should be considered when designing experimental dose response studies that will assist in the study of zoonotic neglected tropical diseases globally.

  7. Exergo-Economic Analysis of an Experimental Aircraft Turboprop Engine Under Low Torque Condition

    Science.gov (United States)

    Atilgan, Ramazan; Turan, Onder; Aydin, Hakan

    Exergo-economic analysis is an unique combination of exergy analysis and cost analysis conducted at the component level. In exergo-economic analysis, cost of each exergy stream is determined. Inlet and outlet exergy streams of the each component are associated to a monetary cost. This is essential to detect cost-ineffective processes and identify technical options which could improve the cost effectiveness of the overall energy system. In this study, exergo-economic analysis is applied to an aircraft turboprop engine. Analysis is based on experimental values at low torque condition (240 N m). Main components of investigated turboprop engine are the compressor, the combustor, the gas generator turbine, the free power turbine and the exhaust. Cost balance equations have been formed for all components individually and exergo-economic parameters including cost rates and unit exergy costs have been calculated for each component.

  8. Educational expansion and the education gradient in health: A hierarchical age-period-cohort analysis.

    Science.gov (United States)

    Delaruelle, Katrijn; Buffel, Veerle; Bracke, Piet

    2015-11-01

    Researchers have recently been investigating the temporal variation in the educational gradient in health. While there is abundant literature concerning age trajectories, theoretical knowledge about cohort differences is relatively limited. Therefore, in analogy with the life course perspective, we introduce two contrasting cohort-specific hypotheses. The diminishing health returns hypothesis predicts a decrease in educational disparities in health across cohorts. By contrast, the cohort accretion hypothesis suggests that the education-health gap will be more pronounced among younger cohorts. To shed light on this, we perform a hierarchical age-period-cohort analysis (HAPC), using data from a subsample of individuals between 25 and 85 years of age (N = 232,573) from 32 countries in the European Social Survey (six waves: 2002-2012). The analysis leads to three important conclusions. First, we observe a widening health gap between different educational levels over the life course. Second, we find that these educational differences in the age trajectories of health seem to strengthen with each successive birth cohort. However, the two age-related effects disappear when we control for employment status, household income, and family characteristics. Last, when adjusting for these mediators, we reveal evidence to support the diminishing health returns hypothesis, implying that it is primarily the direct association between education and health that decreases across cohorts. This finding raises concerns about potential barriers to education being a vehicle for empowerment and the promotion of health.

  9. Forecasting Age-Specific Brain Cancer Mortality Rates Using Functional Data Analysis Models

    Directory of Open Access Journals (Sweden)

    Keshav P. Pokhrel

    2015-01-01

    Full Text Available Incidence and mortality rates are considered as a guideline for planning public health strategies and allocating resources. We apply functional data analysis techniques to model age-specific brain cancer mortality trend and forecast entire age-specific functions using exponential smoothing state-space models. The age-specific mortality curves are decomposed using principal component analysis and fit functional time series model with basis functions. Nonparametric smoothing methods are used to mitigate the existing randomness in the observed data. We use functional time series model on age-specific brain cancer mortality rates and forecast mortality curves with prediction intervals using exponential smoothing state-space model. We also present a disparity of brain cancer mortality rates among the age groups together with the rate of change of mortality rates. The data were obtained from the Surveillance, Epidemiology and End Results (SEER program of the United States. The brain cancer mortality rates, classified under International Classification Disease code ICD-O-3, were extracted from SEER*Stat software.

  10. The theoretical analysis and experimental research on the optimal condition of semiconductor refrigeration

    Science.gov (United States)

    Pang, Y. F.

    2016-08-01

    The traditional limiting conditions have the biggest refrigeration quantity condition and the biggest refrigeration coefficient condition, there is a special operating mode during these conditions, enabling to both have the big refrigeration quantity and the small power loss, this operating mode is “Optimum condition”. This article first carried on the theoretical analysis to the semiconductor's optimum condition, inferred optimum electric current's theoretical formula; Carried on the experiment again to a semiconductor refrigeration box by regulating current changing operating mode, which had analyzed performance parameter's change situation under 8 kinds of condition experiments, carried on the regression analysis to the experimental data, obtained the regression equation thus discovered optimum electric current corresponding optimum condition. Carried on working under this condition, and then obtained the big refrigeration quantity and small power, which enhanced the refrigeration performance of semiconductor refrigerator. The experimental result and the theoretical analysis result tallied basically.

  11. Experimental investigation and performance analysis of inertia properties measurement for heavy truck cab

    Directory of Open Access Journals (Sweden)

    Tianjun Zhu

    2015-11-01

    Full Text Available An experimental investigation and performance analysis of inertia properties measurement for heavy truck cab is presented. This method is specifically intended for measuring the inertia properties of irregular rigid bodies, and it has the potential to be applied to the measurement of the inertia properties of vehicle bodies, such as the cab, engine, and gearbox. This article, based on CATARC moment of inertia measurement system test rig, develops an accurate measuring method to identify inertia parameters of heavy truck cab. First, corresponding tests are carried out, and the lever principle and moments of inertia parallel theorem are employed to calculate and analyse the test results, which leads to the accurate value of inertia parameters. Second, the performance analysis of the proposed method is verified through the measurement error analysis. As a result, the proposed method shows high accuracy, which provides an experimental basis for accurate inertia parameter measurement of heavy truck cab.

  12. Theoretical and experimental analysis of inverter fed induction motor system under DC link capacitor failure

    Directory of Open Access Journals (Sweden)

    Hadeed A. Sher

    2017-04-01

    Full Text Available In this paper theoretical and experimental analysis of an AC–DC–AC inverter under DC link capacitor failure is presented. The failure study conducted for this paper is the open circuit of the DC link capacitor. The presented analysis incorporates the results for both single and three phase AC input. It has been observed that the higher ripple frequency provides better ride through capability for this fault. Furthermore, the effects of this fault on electrical characteristics of AC–DC–AC inverter and mechanical properties of the induction motor are also presented. Moreover, the effect of pulsating torque as a result of an open circuited DC link capacitor is also taken into consideration. Theoretical analysis is supported by computer aided simulation as well as with a real time experimental prototype.

  13. Stereochemical analysis of menthol and menthylamine isomers using calculated and experimental optical rotation data

    Science.gov (United States)

    Reinscheid, F.; Reinscheid, U. M.

    2016-01-01

    The complete series of menthol isomers and their corresponding amino derivatives (base and protonated/HCl forms), were investigated using experimental and theoretical data. Our study focused on the conformational and configurational analysis, and revealed that experimental data should be used in combination with calculated data. Furthermore, even in the case of the highly studied member, menthol, discrepancies were found among previously published literature values. We show that the correct determination of the population mix is a must for the correct prediction of the absolute configuration (AC) of neoisomenthol. The neoiso forms are of special interest since a number of structural inconsistences can be found in the literature. We present a stringent proof of the AC of neoisomenthol based on literature information. To the best of our knowledge, the AC of neoisomenthylamine is for the first time shown using experimental and calculated optical rotation data. A correction of a series of publications containing an important error in the assignment of (+)-menthylamine (correct: (+)-neomenthylamine) is presented. With 26 data pairs (experimental versus calculated) of optical rotation values a regression is performed. The AC of all 12 compounds, even the most difficult neoiso forms, could be predicted correctly using experimental low-temperature NMR data. Furthermore, if only experimental data with an optical rotation outside the range of -10 +10 are used, all 12 compounds would have been correctly assigned without low-temperature NMR data as restraints.

  14. Financial analysis of experimental releases conducted at Glen Canyon Dam during water years 2006 through 2010.

    Energy Technology Data Exchange (ETDEWEB)

    Poch, L. A.; Veselka, T. D.; Palmer, C. S.; Loftin, S.; Osiek, B. (Decision and Information Sciences); (Western Area Power Administration, Colorado River Storage Project Management Center)

    2011-08-22

    Because of concerns about the impact that Glen Canyon Dam (GCD) operations were having on downstream ecosystems and endangered species, the Bureau of Reclamation (Reclamation) conducted an Environmental Impact Statement (EIS) on dam operations (DOE 1996). New operating rules and management goals for GCD that had been specified in the Record of Decision (ROD) (Reclamation 1996) were adopted in February 1997. In addition to issuing new operating criteria, the ROD mandated experimental releases for the purpose of conducting scientific studies. A report released in January 2011 examined the financial implications of the experimental flows that were conducted at the GCD from 1997 to 2005. This report continues the analysis and examines the financial implications of the experimental flows conducted at the GCD from 2006 to 2010. An experimental release may have either a positive or negative impact on the financial value of energy production. This study estimates the financial costs of experimental releases, identifies the main factors that contribute to these costs, and compares the interdependencies among these factors. An integrated set of tools was used to compute the financial impacts of the experimental releases by simulating the operation of the GCD under two scenarios, namely, (1) a baseline scenario that assumes both that operations comply with the ROD operating criteria and the experimental releases that actually took place during the study period, and (2) a 'without experiments' scenario that is identical to the baseline scenario of operations that comply with the GCD ROD, except it assumes that experimental releases did not occur. The Generation and Transmission Maximization (GTMax) model was the main simulation tool used to dispatch GCD and other hydropower plants that comprise the Salt Lake City Area Integrated Projects (SLCA/IP). Extensive data sets and historical information on SLCA/IP powerplant characteristics, hydrologic conditions, and Western

  15. Deep Proteome Analysis Identifies Age-Related Processes in C. elegans.

    Science.gov (United States)

    Narayan, Vikram; Ly, Tony; Pourkarimi, Ehsan; Murillo, Alejandro Brenes; Gartner, Anton; Lamond, Angus I; Kenyon, Cynthia

    2016-08-01

    Effective network analysis of protein data requires high-quality proteomic datasets. Here, we report a near doubling in coverage of the C. elegans adult proteome, identifying >11,000 proteins in total with ∼9,400 proteins reproducibly detected in three biological replicates. Using quantitative mass spectrometry, we identify proteins whose abundances vary with age, revealing a concerted downregulation of proteins involved in specific metabolic pathways and upregulation of cellular stress responses with advancing age. Among these are ∼30 peroxisomal proteins, including the PRX-5/PEX5 import protein. Functional experiments confirm that protein import into the peroxisome is compromised in vivo in old animals. We also studied the behavior of the set of age-variant proteins in chronologically age-matched, long-lived daf-2 insulin/IGF-1-pathway mutants. Unexpectedly, the levels of many of these age-variant proteins did not scale with extended lifespan. This indicates that, despite their youthful appearance and extended lifespans, not all aspects of aging are reset in these long-lived mutants.

  16. Age-Related Differences in Gait Kinematics, Kinetics, and Muscle Function: A Principal Component Analysis.

    Science.gov (United States)

    Schloemer, Sarah A; Thompson, Julie A; Silder, Amy; Thelen, Darryl G; Siston, Robert A

    2017-03-01

    Age-related increased hip extensor recruitment during gait is a proposed compensation strategy for reduced ankle power generation and may indicate a distal-to-proximal shift in muscle function with age. Extending beyond joint level analyses, identifying age-related changes at the muscle level could capture more closely the underlying mechanisms responsible for movement. The purpose of this study was to characterize and compare muscle forces and induced accelerations during gait in healthy older adults with those of young adults. Simulations of one gait cycle for ten older (73.9 ± 5.3 years) and six young (21.0 ± 2.1 years) adults walking at their self-selected speed were analyzed. Muscle force and induced acceleration waveforms, along with kinematic, kinetic, and muscle activation waveforms, were compared between age-groups using principal component analysis. Simulations of healthy older adults had greater gluteus maximus force and vertical support contribution, but smaller iliacus force, psoas force, and psoas vertical support contribution. There were no age-group differences in distal muscle force, contribution, or ankle torque magnitudes. Later peak dorsiflexion and peak ankle angular velocity in older adults may have contributed to their greater ankle power absorption during stance. These findings reveal the complex interplay between age-related changes in neuromuscular control, kinematics, and muscle function during gait.

  17. Age-Related Impairment of Quality of Joint Motion in Vibroarthrographic Signal Analysis

    Directory of Open Access Journals (Sweden)

    Dawid Bączkowicz

    2015-01-01

    Full Text Available Aging is associated with degenerative changes in articular surfaces leading to quantitative and qualitative impairment of joint motion. Therefore, the aim of this study is to evaluate an age-related quality of the patellofemoral joint (PFJ motion in the vibroarthrographic (VAG signal analysis. Two hundred and twenty individuals were enrolled in this study and divided into five groups according to age. The VAG signals were collected during flexion/extension knee motion using an acceleration sensor and described using four parameters (VMS, P1, P2, and H. We observed that values of parameters VMS, P1, and P2 increase in accordance with the age, but H level decreases. The most significant differences were achieved between the youngest and the oldest participants’ groups. Moreover, we show that parameters VMS, P1, and P2 positively correlate with age, contrary to negatively associated H parameter. Our results suggest that the impairment of joint motion is a result of age-related osteoarticular degenerative changes.

  18. Errors associated with metabolic control analysis. Application Of Monte-Carlo simulation of experimental data.

    Science.gov (United States)

    Ainscow, E K; Brand, M D

    1998-09-21

    The errors associated with experimental application of metabolic control analysis are difficult to assess. In this paper, we give examples where Monte-Carlo simulations of published experimental data are used in error analysis. Data was simulated according to the mean and error obtained from experimental measurements and the simulated data was used to calculate control coefficients. Repeating the simulation 500 times allowed an estimate to be made of the error implicit in the calculated control coefficients. In the first example, state 4 respiration of isolated mitochondria, Monte-Carlo simulations based on the system elasticities were performed. The simulations gave error estimates similar to the values reported within the original paper and those derived from a sensitivity analysis of the elasticities. This demonstrated the validity of the method. In the second example, state 3 respiration of isolated mitochondria, Monte-Carlo simulations were based on measurements of intermediates and fluxes. A key feature of this simulation was that the distribution of the simulated control coefficients did not follow a normal distribution, despite simulation of the original data being based on normal distributions. Consequently, the error calculated using simulation was greater and more realistic than the error calculated directly by averaging the original results. The Monte-Carlo simulations are also demonstrated to be useful in experimental design. The individual data points that should be repeated in order to reduce the error in the control coefficients can be highlighted.

  19. Transcriptome analysis in Ceratitis capitata to unveil genes involved in ageing-maturation process

    Directory of Open Access Journals (Sweden)

    V. San Andrés

    2013-07-01

    Full Text Available The sterile insect technique (SIT is widely used in integrated programmes against the Mediterranean fruit fly, Ceratitis capitata (Wiedemann (Diptera: Tephritidae. Information on the age distribution of insects, and more particularly, the knowledge of wild female reproductive status (mature or not at the time of the sterile male release is one of the key factors for the success of the SIT. In recent years, sequencing analysis has become an important tool in molecular biology. In this work we present a genome-wide expression analysis based on SSH (substractive sequence hybridization and EST (expressed sequence tag sequencing and macroarray expression analysis to identify signature genes related to the ageing-maturing process in C. capitata, leading to the successful identification of new putative candidate genes of reproductive status in medfly that would serve as molecular markers for ageing. We have sorted out 94 unigenes from 873 single-pass ESTs, of which 57% have homology with known genes. Ageing-maturing process in C. capitata presents a marked expression pattern accompanied by the increase of transcription level of genes involved in reproduction (vitellogenins, chorion proteins and male-specific serum proteins. Other identified cDNAs (43% with a differential expression pattern would be also candidates but deserve further studies, as they belong to the unknown function class.

  20. Quantitative analysis of mechanisms that govern red blood cell age structure and dynamics during anaemia.

    Directory of Open Access Journals (Sweden)

    Nicholas J Savill

    2009-06-01

    Full Text Available Mathematical modelling has proven an important tool in elucidating and quantifying mechanisms that govern the age structure and population dynamics of red blood cells (RBCs. Here we synthesise ideas from previous experimental data and the mathematical modelling literature with new data in order to test hypotheses and generate new predictions about these mechanisms. The result is a set of competing hypotheses about three intrinsic mechanisms: the feedback from circulating RBC concentration to production rate of immature RBCs (reticulocytes in bone marrow, the release of reticulocytes from bone marrow into the circulation, and their subsequent ageing and clearance. In addition we examine two mechanisms specific to our experimental system: the effect of phenylhydrazine (PHZ and blood sampling on RBC dynamics. We performed a set of experiments to quantify the dynamics of reticulocyte proportion, RBC concentration, and erythropoietin concentration in PHZ-induced anaemic mice. By quantifying experimental error we are able to fit and assess each hypothesis against our data and recover parameter estimates using Markov chain Monte Carlo based Bayesian inference. We find that, under normal conditions, about 3% of reticulocytes are released early from bone marrow and upon maturation all cells are released immediately. In the circulation, RBCs undergo random clearance but have a maximum lifespan of about 50 days. Under anaemic conditions reticulocyte production rate is linearly correlated with the difference between normal and anaemic RBC concentrations, and their release rate is exponentially correlated with the same. PHZ appears to age rather than kill RBCs, and younger RBCs are affected more than older RBCs. Blood sampling caused short aperiodic spikes in the proportion of reticulocytes which appear to have a different developmental pathway than normal reticulocytes. We also provide evidence of large diurnal oscillations in serum erythropoietin levels

  1. Conceptualizing age-friendly community characteristics in a sample of urban elders: an exploratory factor analysis.

    Science.gov (United States)

    Smith, Richard J; Lehning, Amanda J; Dunkle, Ruth E

    2013-01-01

    Accurate conceptualization and measurement of age-friendly community characteristics would help to reduce barriers to documenting the effects on elders of interventions to create such communities. This article contributes to the measurement of age-friendly communities through an exploratory factor analysis of items reflecting an existing US Environmental Protection Agency policy framework. From a sample of urban elders (n = 1,376), we identified 6 factors associated with demographic and health characteristics: access to business and leisure, social interaction, access to health care, neighborhood problems, social support, and community engagement. Future research should explore the effects of these factors across contexts and populations.

  2. Efficient experimental design and analysis strategies for the detection of differential expression using RNA-Sequencing

    Directory of Open Access Journals (Sweden)

    Robles José A

    2012-09-01

    Full Text Available Abstract Background RNA sequencing (RNA-Seq has emerged as a powerful approach for the detection of differential gene expression with both high-throughput and high resolution capabilities possible depending upon the experimental design chosen. Multiplex experimental designs are now readily available, these can be utilised to increase the numbers of samples or replicates profiled at the cost of decreased sequencing depth generated per sample. These strategies impact on the power of the approach to accurately identify differential expression. This study presents a detailed analysis of the power to detect differential expression in a range of scenarios including simulated null and differential expression distributions with varying numbers of biological or technical replicates, sequencing depths and analysis methods. Results Differential and non-differential expression datasets were simulated using a combination of negative binomial and exponential distributions derived from real RNA-Seq data. These datasets were used to evaluate the performance of three commonly used differential expression analysis algorithms and to quantify the changes in power with respect to true and false positive rates when simulating variations in sequencing depth, biological replication and multiplex experimental design choices. Conclusions This work quantitatively explores comparisons between contemporary analysis tools and experimental design choices for the detection of differential expression using RNA-Seq. We found that the DESeq algorithm performs more conservatively than edgeR and NBPSeq. With regard to testing of various experimental designs, this work strongly suggests that greater power is gained through the use of biological replicates relative to library (technical replicates and sequencing depth. Strikingly, sequencing depth could be reduced as low as 15% without substantial impacts on false positive or true positive rates.

  3. Fusion of Fingerprint and Age Biometric for Gender Classification Using Frequency and Texture Analysis

    Directory of Open Access Journals (Sweden)

    S. S. Gornale

    2014-12-01

    Full Text Available Classification of gender from fingerprints is one of the important steps in forensic anthropology. This forensic anthropology is used to identify the gender of a criminal in order to minimize the suspects list of search. A very few researcher have worked on gender classification using fingerprints and have gain the competitive results. In this work we are trying to fuse the fingerprint and age biometrics for gender classification. The real fingerprints were collected from different age groups such as 15-20 years and 20- 60 years of the rural and urban people. According to this experimental observation soft biometric information can be used significantly to improve the recognition performance of biometric system. The overall performance of the proposed method is found to be satisfactory and more competitive.

  4. Development of Evaluation Methods for Lower Limb Function between Aged and Young Using Principal Component Analysis

    Science.gov (United States)

    Nomoto, Yohei; Yamashita, Kazuhiko; Ohya, Tetsuya; Koyama, Hironori; Kawasumi, Masashi

    There is the increasing concern of the society to prevent the fall of the aged. The improvement in aged people's the muscular strength of the lower-limb, postural control and walking ability are important for quality of life and fall prevention. The aim of this study was to develop multiple evaluation methods in order to advise for improvement and maintenance of lower limb function between aged and young. The subjects were 16 healthy young volunteers (mean ± S.D: 19.9 ± 0.6 years) and 10 healthy aged volunteers (mean ± S.D: 80.6 ± 6.1 years). Measurement items related to lower limb function were selected from the items which we have ever used. Selected measurement items of function of lower are distance of extroversion of the toe, angle of flexion of the toe, maximum width of step, knee elevation, moving distance of greater trochanter, walking balance, toe-gap force and rotation range of ankle joint. Measurement items summarized by the principal component analysis into lower ability evaluation methods including walking ability and muscle strength of lower limb and flexibility of ankle. The young group demonstrated the factor of 1.6 greater the assessment score of walking ability compared with the aged group. The young group demonstrated the factor of 1.4 greater the assessment score of muscle strength of lower limb compared with the aged group. The young group demonstrated the factor of 1.2 greater the assessment score of flexibility of ankle compared with the aged group. The results suggested that it was possible to assess the lower limb function of aged and young numerically and to advise on their foot function.

  5. A Randomised Controlled Experimental Study on the Influence of Patient Age on Medical Decisions in Respect to the Diagnosis and Treatment of Depression in the Elderly

    Directory of Open Access Journals (Sweden)

    Michael Linden

    2009-01-01

    Full Text Available Background. Elderly patients are often treated differently than younger patients, even when suffering from the same disorder. Objective. The study examines the influence of “patient age” on the perception of symptoms and conclusions of physicians in respect to diagnosis and treatment. Methods. In a randomised controlled experimental study on medical decision-making, 121 general practitioners were given two case vignettes which contained all the criteria for major depression according to ICD-10, but differed in respect to the age of the patient (39 or 81. Reaction time, diagnostic conclusions and therapeutic recommendations were assessed by computer. Results. Depression and anxiety were significantly seen as more probable in the young cases and dementia and physical illness in the old. In young age, psychotherapy, pharmacotherapy and referral to a specialist or inpatient treatment were significantly more recommended than in old age, for whom supportive counselling was significantly more recommended. The time needed for a decision was significantly longer in the older patients. Conclusion. Ageing stereotypes can also form medical illness concepts and have a significant influence on diagnostic and therapeutic decisions.

  6. Experimental study and analysis on fatigue stiffness of RC beams strengthened with CFRP and steel plate

    Institute of Scientific and Technical Information of China (English)

    LU Yi-yan; HU Ling; LI Shan; WANG Kang-hao

    2016-01-01

    The objective of this work is to investigate the fatigue behavior of reinforced concrete (RC) beams strengthened with externally bonded carbon fiber reinforced polymer (CFRP) and steel plate. An experimental investigation and theoretical analysis were made on the law of deflection development and stiffness degradation, as well as the influence of fatigue load ranges. Test results indicate that the law of three-stage change under fatigue loading is followed by both midspan deflection and permanent deflection, which also have positive correlation with fatigue load amplitude. Fatigue stiffness of composite strengthened beams degrades gradually with the increasing of number of cycles. Based on the experimental results, a theoretical model by effective moment of inertia method is developed for calculating the sectional stiffness of such composite strengthened beams under fatigue loading, and the calculated results are in good agreement with the experimental results.

  7. Experimental investigation on heat transfer analysis of conical coil heat exchanger with 90° cone angle

    Science.gov (United States)

    Purandare, Pramod S.; Lele, Mandar M.; Gupta, Raj Kumar

    2015-03-01

    In the present study, an experimental investigation on thermal performance of the conical coil heat exchanger with 90° conical coil heat exchanger is reported. Three different conical coil heat exchangers of same mean coil diameter (Dm = 200 mm) with different tube diameters ( di = 8, 10, 12.5 mm) are analyzed under steady state condition. The analysis is carried out for the tube side hot fluid flow range of 10-100 lph ( Re = 500-5,000), while the shell side flow range of 30-90 lph. The data available from experimentation leads to evaluate heat transfer coefficients for inside and outside the tube of the conical coil heat exchanger by Wilsons plot method. The calculations are further extended to estimate Nusselt Number ( Nu) and effectiveness. The empirical correlations are proposed for predicting Nu and the outlet temperatures of hot and cold fluids. The predicted empirical correlations show reasonable agreement with the experimental results within the given range of parameters.

  8. Experimental and theoretical analysis of vortex breakdown in the wake of the 25∘ Ahmed body

    Science.gov (United States)

    Jermann, Cyril; Meliga, Philippe; Pujals, Gregory; Gallaire, Francois; Serre, Eric

    2014-11-01

    We study experimentally and theoretically the wake of the 25circ; Ahmed body, considered a suitable test-case to reproduce the two counter-rotating longitudinal vortices widely encountered in automotive aerodynamics. The three-dimensional experimental mean flow is reconstructed at high Reynolds number (Re = 2 . 8 ×106) from a series of cross-flow time-averaged planes acquired with a moving automated Stereo-PIV system. We observe a sharp decay of the axial velocity and vorticity in the near-wake, 0 . 5 times the projected length of the slanted surface downstream the square back, where the streamwise vortices is subjected to a strong adverse pressure gradient and the turbulent kinetic energy exhibits a peak in the vortex core. A stability analysis of the experimental velocity shows that the flow undergoes vortex breakdown roughly at the same position, through a transition from supercritical (x 0 . 5) conditions and the accumulation of upstream propagating axisymmetric waves.

  9. Updating Finite Element Model of a Wind Turbine Blade Section Using Experimental Modal Analysis Results

    DEFF Research Database (Denmark)

    Luczak, Marcin; Manzato, Simone; Peeters, Bart;

    2014-01-01

    of model parameters was selected for the model updating process. Design of experiment and response surface method was implemented to find values of model parameters yielding results closest to the experimental. The updated finite element model is producing results more consistent with the measurement...... is to validate finite element model of the modified wind turbine blade section mounted in the flexible support structure accordingly to the experimental results. Bend-twist coupling was implemented by adding angled unidirectional layers on the suction and pressure side of the blade. Dynamic test and simulations...... were performed on a section of a full scale wind turbine blade provided by Vestas Wind Systems A/S. The numerical results are compared to the experimental measurements and the discrepancies are assessed by natural frequency difference and modal assurance criterion. Based on sensitivity analysis, set...

  10. Application of Elliptic Fourier analysis to describe the lamina cribrosa shape with age and intraocular pressure.

    Science.gov (United States)

    Sanfilippo, P G; Grimm, J L; Flanagan, J G; Lathrop, K L; Sigal, I A

    2014-11-01

    The lamina cribrosa (LC) plays an important biomechanical role in the optic nerve head (ONH). We developed a statistical shape model of the LC and tested if the shape varies with age or IOP. The ONHs of 18 donor eyes (47-91 years, mean 76 years) fixed at either 5 or 50 mmHg of IOP were sectioned, stained, and imaged under a microscope. A 3D model of each ONH was reconstructed and the outline of the vertical sagittal section closest to the geometric center of the LC extracted. The outline shape was described using Elliptic Fourier analysis, and principal components analysis (PCA) employed to identify the primary modes of LC shape variation. Linear mixed effect models were used to determine if the shape measurements were associated with age or IOP. The analysis revealed several modes of shape variation: thickness and depth directly (PC 1), or inversely (PC 2) related, and superior-inferior asymmetry (PC 3). Only PC 3 was associated with IOP, with higher IOP correlating with greater curvature of the LC superiorly compared to inferiorly. Our analysis enabled a concise and complete characterization of LC shape, revealing variations without defining them a priori. No association between LC shape and age was found for the relatively old population studied. Superior-inferior asymmetry of LC shape was associated with IOP, with more asymmetry at higher IOP. Increased IOP was not associated with LC thickness or depth.

  11. Seismic Fragility Analysis of a Condensate Storage Tank with Age-Related Degradations

    Energy Technology Data Exchange (ETDEWEB)

    Nie, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Braverman, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Hofmayer, C [Brookhaven National Lab. (BNL), Upton, NY (United States); Choun, Y-S [Brookhaven National Lab. (BNL), Upton, NY (United States); Kim, MK [Brookhaven National Lab. (BNL), Upton, NY (United States); Choi, I-K [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2011-04-01

    The Korea Atomic Energy Research Institute (KAERI) is conducting a five-year research project to develop a realistic seismic risk evaluation system which includes the consideration of aging of structures and components in nuclear power plants (NPPs). The KAERI research project includes three specific areas that are essential to seismic probabilistic risk assessment (PRA): (1) probabilistic seismic hazard analysis, (2) seismic fragility analysis including the effects of aging, and (3) a plant seismic risk analysis. Since 2007, Brookhaven National Laboratory (BNL) has entered into a collaboration agreement with KAERI to support its development of seismic capability evaluation technology for degraded structures and components. The collaborative research effort is intended to continue over a five year period. The goal of this collaboration endeavor is to assist KAERI to develop seismic fragility analysis methods that consider the potential effects of age-related degradation of structures, systems, and components (SSCs). The research results of this multi-year collaboration will be utilized as input to seismic PRAs. This report describes the research effort performed by BNL for the Year 4 scope of work. This report was developed as an update to the Year 3 report by incorporating a major supplement to the Year 3 fragility analysis. In the Year 4 research scope, an additional study was carried out to consider an additional degradation scenario, in which the three basic degradation scenarios, i.e., degraded tank shell, degraded anchor bolts, and cracked anchorage concrete, are combined in a non-perfect correlation manner. A representative operational water level is used for this effort. Building on the same CDFM procedure implemented for the Year 3 Tasks, a simulation method was applied using optimum Latin Hypercube samples to characterize the deterioration behavior of the fragility capacity as a function of age-related degradations. The results are summarized in Section 5

  12. Age and Anomia in Middle and Later Life: A Multivariate Analysis of a National Sample of White Men.

    Science.gov (United States)

    Pope, Hallowell; Ferguson, Miller Dwayne

    1982-01-01

    Tested whether the aged status in America results in distrust and despair with the social order (anomia). A multivariate regression analysis utilizing data on 354 men aged 40 and older showed no relationship between age or other indicators of life chances or anomia, net of education and/or verbal intelligence. (Author/RC)

  13. Stability and sensitivity analysis of experimental data for passive control of a turbulent wake

    Science.gov (United States)

    Siconolfi, Lorenzo; Camarri, Simone; Trip, Renzo; Fransson, Jens H. M.

    2016-11-01

    When the linear stability analysis is applied to the mean flow field past a bluff body, a quasi-marginally stable mode is identified, with a frequency very close to the real vortex shedding one. A formally consistent approach to justify this kind of analysis is based on a triple decomposition of the flow variables. With this formalism, the adjoint-based sensitivity analysis can be extended to investigate passive controls of high-Reynolds-number wakes (e.g.). The objective of the present work is to predict the effect of a small control cylinder on the vortex shedding frequency in a turbulent wake with an analysis which solely relies on PIV measurements available for the considered flow. The key ingredient of the numerical analysis is an ad-hoc tuned model for the mean flow field, built using an original procedure which includes all the experimental information available on the flow. This analysis is here applied to the wake flow past a thick porous plate at Reynolds numbers in the range between Re = 6 . 7 ×103 and Re= 5 . 3 ×104 . It is shown that the derived control map agrees reasonably well with the equivalent map obtained experimentally.

  14. The emergence of modern statistics in agricultural science: analysis of variance, experimental design and the reshaping of research at Rothamsted Experimental Station, 1919-1933.

    Science.gov (United States)

    Parolini, Giuditta

    2015-01-01

    During the twentieth century statistical methods have transformed research in the experimental and social sciences. Qualitative evidence has largely been replaced by quantitative results and the tools of statistical inference have helped foster a new ideal of objectivity in scientific knowledge. The paper will investigate this transformation by considering the genesis of analysis of variance and experimental design, statistical methods nowadays taught in every elementary course of statistics for the experimental and social sciences. These methods were developed by the mathematician and geneticist R. A. Fisher during the 1920s, while he was working at Rothamsted Experimental Station, where agricultural research was in turn reshaped by Fisher's methods. Analysis of variance and experimental design required new practices and instruments in field and laboratory research, and imposed a redistribution of expertise among statisticians, experimental scientists and the farm staff. On the other hand the use of statistical methods in agricultural science called for a systematization of information management and made computing an activity integral to the experimental research done at Rothamsted, permanently integrating the statisticians' tools and expertise into the station research programme. Fisher's statistical methods did not remain confined within agricultural research and by the end of the 1950s they had come to stay in psychology, sociology, education, chemistry, medicine, engineering, economics, quality control, just to mention a few of the disciplines which adopted them.

  15. Analysis, prediction, and case studies of early-age cracking in bridge decks

    Science.gov (United States)

    ElSafty, Adel; Graeff, Matthew K.; El-Gharib, Georges; Abdel-Mohti, Ahmed; Mike Jackson, N.

    2016-06-01

    Early-age cracking can adversely affect strength, serviceability, and durability of concrete bridge decks. Early age is defined as the period after final setting, during which concrete properties change rapidly. Many factors can cause early-age bridge deck cracking including temperature change, hydration, plastic shrinkage, autogenous shrinkage, and drying shrinkage. The cracking may also increase the effect of freeze and thaw cycles and may lead to corrosion of reinforcement. This research paper presents an analysis of causes and factors affecting early-age cracking. It also provides a tool developed to predict the likelihood and initiation of early-age cracking of concrete bridge decks. Understanding the concrete properties is essential so that the developed tool can accurately model the mechanisms contributing to the cracking of concrete bridge decks. The user interface of the implemented computer Excel program enables the user to input the properties of the concrete being monitored. The research study and the developed spreadsheet were used to comprehensively investigate the issue of concrete deck cracking. The spreadsheet is designed to be a user-friendly calculation tool for concrete mixture proportioning, temperature prediction, thermal analysis, and tensile cracking prediction. The study also provides review and makes recommendations on the deck cracking based mainly on the Florida Department of Transportation specifications and Structures Design Guidelines, and Bridge Design Manuals of other states. The results were also compared with that of other commercially available software programs that predict early-age cracking in concrete slabs, concrete pavement, and reinforced concrete bridge decks. The outcome of this study can identify a set of recommendations to limit the deck cracking problem and maintain a longer service life of bridges.

  16. [Aging Process of Puer Black Tea Studied by FTIR Spectroscopy Combined with Curve-Fitting Analysis].

    Science.gov (United States)

    Li, Dong-yu; Shi, You-ming; Yi, Shi Lai

    2015-07-01

    For better determination of the chemical components in the Puer black tea, Fourier transform infrared spectroscopy was used for obtaining vibrational spectra of Puer black tea at different aging time. Fourier transform infrared (FTIR) spectra indicated that the chemical components had change in Puer black tea at different aging time. The leaf of Puer black tea was a complex system, its Fourier transform infrared spectrum showed a total overlap of each absorption spectrum of various components. Each band represented an overall overlap of some characteristic absorption peaks of functional groups in the Puer black tea. In order to explore the change of characteristic absorption peaks of functional groups with aging time, the prediction positions and the number of second peaks in the range of 1900-900 cm(-1) were determined by Fourier self-deconvolution at first, and later the curve fitting analysis was performed in this overlap band. At different aging time of Puer black tea, the wave number of second peaks of amide II, tea polyphenol, pectin and polysaccharides at overlap band were assigned by curve fitting analysis. The second peak at 1520 cm(-1) was characteristic absorption band of amide II, the second peaks of tea polyphenol and pectin appeared at 1278 and 1103 cm(-1) respectively. Two second peaks at 1063 and 1037 cm(-1), corresponds mainly to glucomannan and arabinan. The relative area of these second peaks could be indicated the content of protein, tea polyphenol, pectin and polysaccharides in the Puer black tea. The results of curve fitting analysis showed that the relative area of amide II was increasing first and then decreasing, it indicated the change of protein in Puer black tea. At the same time, the content of tea polyphenol and pectin were decreased with the increase of aging time, but the glucomannan and arabinan were increased in reverse. It explained that the bitter taste was become weak and a sweet taste appeared in the tea with the increase of

  17. Identification of the dichotomous role of age-related LCK in calorie restriction revealed by integrative analysis of cDNA microarray and interactome.

    Science.gov (United States)

    Park, Daeui; Lee, Eun Kyeong; Jang, Eun Jee; Jeong, Hyoung Oh; Kim, Byoung-Chul; Ha, Young Mi; Hong, Seong Eui; Yu, Byung Pal; Chung, Hae Young

    2013-08-01

    Among the many experimental paradigms used for the investigation of aging, the calorie restriction (CR) model has been proven to be the most useful in gerontological research. Exploration of the mechanisms underlying CR has produced a wealth of data. To identify key molecules controlled by aging and CR, we integrated data from 84 mouse and rat cDNA microarrays with a protein-protein interaction network. On the basis of this integrative analysis, we selected three genes that are upregulated in aging but downregulated by CR and two genes that are downregulated in aging but upregulated by CR. One of these key molecules is lymphocyte-specific protein tyrosine kinase (LCK). To further confirm this result on LCK, we performed a series of experiments in vitro and in vivo using kidneys obtained from aged ad libitum-fed and CR rats. Our major significant findings are as follows: (1) identification of LCK as a key molecule using integrative analysis; (2) confirmation that the age-related increase in LCK was modulated by CR and that protein tyrosine kinase activity was decreased using a LCK-specific inhibitor; and (3) upregulation of LCK leads to NF-κB activation in a ONOO(-) generation-dependent manner, which is modulated by CR. These results indicate that LCK could be considered a target attenuated by the anti-aging effects of CR. Integrative analysis of cDNA microarray and interactome data are powerful tools for identifying target molecules that are involved in the aging process and modulated by CR.

  18. Quantitative analysis of cone photoreceptor distribution and its relationship with axial length, age, and early age-related macular degeneration.

    Directory of Open Access Journals (Sweden)

    Ryo Obata

    Full Text Available PURPOSE: It has not been clarified whether early age-related macular degeneration (AMD is associated with cone photoreceptor distribution. We used adaptive optics fundus camera to examine cone photoreceptors in the macular area of aged patients and quantitatively analyzed its relationship between the presence of early AMD and cone distribution. METHODS: Sixty cases aged 50 or older were studied. The eyes were examined with funduscopy and spectral-domain optical coherence tomography to exclude the eyes with any abnormalities at two sites of measurement, 2° superior and 5° temporal to the fovea. High-resolution retinal images with cone photoreceptor mosaic were obtained with adaptive optics fundus camera (rtx1, Imagine Eyes, France. After adjusting for axial length, cone packing density was calculated and the relationship with age, axial length, or severity of early AMD based on the age-related eye disease study (AREDS classification was analyzed. RESULTS: Patient's age ranged from 50 to 77, and axial length from 21.7 to 27.5 mm. Mean density in metric units and that in angular units were 24,900 cells/mm2, 2,170 cells/deg2 at 2° superior, and 18,500 cells/mm2, 1,570 cels/deg2 at 5° temporal, respectively. Axial length was significantly correlated with the density calculated in metric units, but not with that in angular units. Age was significantly correlated with the density both in metric and angular units at 2° superior. There was no significant difference in the density in metric and angular units between the eyes with AREDS category one and those with categories two or three. CONCLUSION: Axial length and age were significantly correlated with parafoveal cone photoreceptor distribution. The results do not support that early AMD might influence cone photoreceptor density in the area without drusen or pigment abnormalities.

  19. Experimental and theoretical analysis of a hybrid solar thermoelectric generator with forced convection cooling

    Science.gov (United States)

    Sundarraj, Pradeepkumar; Taylor, Robert A.; Banerjee, Debosmita; Maity, Dipak; Sinha Roy, Susanta

    2017-01-01

    Hybrid solar thermoelectric generators (HSTEGs) have garnered significant research attention recently due to their potential ability to cogenerate heat and electricity. In this paper, theoretical and experimental investigations of the electrical and thermal performance of a HSTEG system are reported. In order to validate the theoretical model, a laboratory scale HSTEG system (based on forced convection cooling) is developed. The HSTEG consists of six thermoelectric generator modules, an electrical heater, and a stainless steel cooling block. Our experimental analysis shows that the HSTEG is capable of producing a maximum electrical power output of 4.7 W, an electrical efficiency of 1.2% and thermal efficiency of 61% for an average temperature difference of 92 °C across the TEG modules with a heater power input of 382 W. These experimental results of the HSTEG system are found to be in good agreement with the theoretical prediction. This experimental/theoretical analysis can also serve as a guide for evaluating the performance of the HSTEG system with forced convection cooling.

  20. Experimental saltwater intrusion in coastal aquifers using automated image analysis: Applications to homogeneous aquifers

    Science.gov (United States)

    Robinson, G.; Ahmed, Ashraf A.; Hamill, G. A.

    2016-07-01

    This paper presents the applications of a novel methodology to quantify saltwater intrusion parameters in laboratory-scale experiments. The methodology uses an automated image analysis procedure, minimising manual inputs and the subsequent systematic errors that can be introduced. This allowed the quantification of the width of the mixing zone which is difficult to measure in experimental methods that are based on visual observations. Glass beads of different grain sizes were tested for both steady-state and transient conditions. The transient results showed good correlation between experimental and numerical intrusion rates. The experimental intrusion rates revealed that the saltwater wedge reached a steady state condition sooner while receding than advancing. The hydrodynamics of the experimental mixing zone exhibited similar traits; a greater increase in the width of the mixing zone was observed in the receding saltwater wedge, which indicates faster fluid velocities and higher dispersion. The angle of intrusion analysis revealed the formation of a volume of diluted saltwater at the toe position when the saltwater wedge is prompted to recede. In addition, results of different physical repeats of the experiment produced an average coefficient of variation less than 0.18 of the measured toe length and width of the mixing zone.

  1. Sexual Dimorphism and Aging in the Human Hyppocampus: Identification, Validation, and Impact of Differentially Expressed Genes by Factorial Microarray and Network Analysis

    Science.gov (United States)

    Guebel, Daniel V.; Torres, Néstor V.

    2016-01-01

    Motivation: In the brain of elderly-healthy individuals, the effects of sexual dimorphism and those due to normal aging appear overlapped. Discrimination of these two dimensions would powerfully contribute to a better understanding of the etiology of some neurodegenerative diseases, such as “sporadic” Alzheimer. Methods: Following a system biology approach, top-down and bottom-up strategies were combined. First, public transcriptome data corresponding to the transition from adulthood to the aging stage in normal, human hippocampus were analyzed through an optimized microarray post-processing (Q-GDEMAR method) together with a proper experimental design (full factorial analysis). Second, the identified genes were placed in context by building compatible networks. The subsequent ontology analyses carried out on these networks clarify the main functionalities involved. Results: Noticeably we could identify large sets of genes according to three groups: those that exclusively depend on the sex, those that exclusively depend on the age, and those that depend on the particular combinations of sex and age (interaction). The genes identified were validated against three independent sources (a proteomic study of aging, a senescence database, and a mitochondrial genetic database). We arrived to several new inferences about the biological functions compromised during aging in two ways: by taking into account the sex-independent effects of aging, and considering the interaction between age and sex where pertinent. In particular, we discuss the impact of our findings on the functions of mitochondria, autophagy, mitophagia, and microRNAs. Conclusions: The evidence obtained herein supports the occurrence of significant neurobiological differences in the hippocampus, not only between adult and elderly individuals, but between old-healthy women and old-healthy men. Hence, to obtain realistic results in further analysis of the transition from the normal aging to incipient

  2. Analysis and aging of unsaturated polyester resins in contemporary art installations by NMR spectroscopy.

    Science.gov (United States)

    Stamatakis, Georgios; Knuutinen, Ulla; Laitinen, Kai; Spyros, Apostolos

    2010-12-01

    Two original art installations constructed from unsaturated polyester resins (UPR) and four different reference UPR products (before and after UVB aging) were analyzed by high-resolution 1D and 2D nuclear magnetic resonance (NMR) spectroscopy. Breaking strain studies were also conducted for the four UPR model products before and after different aging procedures (moisture, UVB exposure, melt/freeze). NMR analysis of the chemical composition of the UPR resin extracts showed they contain several low MW organic compounds and oligomers rich in polar -OH groups that play a significant role in the degradation behavior of the composite UPR materials. Statistical analysis of the NMR compositional data showed that styrene and benzaldehyde contents can be used to differentiate between fresh and aged UPR samples. The phthalate and propylene glycol unit speciation (esterified, primary or secondary -OH) of the extracts provided evidence that UPR resin C was used in the construction of the two art installations, and direct comparison of (1)H and (13)C NMR spectra verified this compositional similarity. UPR resin C was shown by both NMR and breaking strain studies to be the reference UPR most susceptible to degradation by different aging procedures, a characteristic attributed to the lower styrene content of resin C.

  3. Identifying controlling variables for math computation fluency through experimental analysis: the interaction of stimulus control and reinforcing consequences.

    Science.gov (United States)

    Hofstadter-Duke, Kristi L; Daly, Edward J

    2015-03-01

    This study investigated a method for conducting experimental analyses of academic responding. In the experimental analyses, academic responding (math computation), rather than problem behavior, was reinforced across conditions. Two separate experimental analyses (one with fluent math computation problems and one with non-fluent math computation problems) were conducted with three elementary school children using identical contingencies while math computation rate was measured. Results indicate that the experimental analysis with non-fluent problems produced undifferentiated responding across participants; however, differentiated responding was achieved for all participants in the experimental analysis with fluent problems. A subsequent comparison of the single-most effective condition from the experimental analyses replicated the findings with novel computation problems. Results are discussed in terms of the critical role of stimulus control in identifying controlling consequences for academic deficits, and recommendations for future research refining and extending experimental analysis to academic responding are made.

  4. Assessment of gait symmetry for Talus Valgus children based on experimental kinematic analysis

    Science.gov (United States)

    Toth-Tascau, Mirela; Pasca, Oana; Vigaru, Cosmina; Rusu, Lucian

    2013-10-01

    The general purpose of this study was to assess the gait symmetry for Talus Valgus deformity based on experimental kinematic analysis. As this foot condition generally occurs in children, the study is focused on two children having five years old, one being healthy, as control subject, and the second one having bilateral Talus Valgus deformity. Kinematic experimental analysis was conducted using Zebris CMS-HS Measuring System. The bilateral symmetry was analyzed using two methods: index of symmetry (SI) calculated for spatio-temporal parameters (stance phase, swing phase, and step length) and kinematic parameter (maximum value of dorsiflexion - plantar flexion angle in the ankle joint), and an unpaired t-test to compare the variation of means values of dorsiflexion - plantar flexion angle in ankle joint for both left and right side. The study evidenced a good bilateral symmetry in case of the control subject and quantified the asymmetry in case of subject with Talus Valgus deformity.

  5. A global analysis of the experimental data on $\\chi_c$ meson hadroproduction

    CERN Document Server

    Jia, Lan; Zhang, Hong-Fei

    2014-01-01

    We carry out a global analysis on the experimental data on $\\chi_c$ production rate and the ratio $\\sigma(\\chi_{c2})/\\sigma(\\chi_{c1})$ at the LHC and Tevatron. The related long-distance matrix elements (LDMEs) at both leading order (LO) and next-to-leading order (NLO) in QCD coupling constant are renewed. We also present the transverse momentum distribution of the $\\chi_c$ production rate and the ratio $\\sigma(\\chi_{c2})/\\sigma(\\chi_{c1})$ for several experimental conditions, and find that NLO predictions agree with all sets of experiment measurements except for one. By contrast, at LO, we can not explain all the experiments by using a single LDME. A brief analysis on the non-relativistic QCD scale dependence of the cross sections shows that, for the conditions we concern in this paper, the dependence can almost be totally absorbed into the LDME.

  6. Comment: Spurious Correlation and Other Observations on Experimental Design for Engineering Dimensional Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Piepel, Gregory F.

    2013-08-01

    This article discusses the paper "Experimental Design for Engineering Dimensional Analysis" by Albrecht et al. (2013, Technometrics). That paper provides and overview of engineering dimensional analysis (DA) for use in developing DA models. The paper proposes methods for generating model-robust experimental designs to supporting fitting DA models. The specific approach is to develop a design that maximizes the efficiency of a specified empirical model (EM) in the original independent variables, subject to a minimum efficiency for a DA model expressed in terms of dimensionless groups (DGs). This discussion article raises several issues and makes recommendations regarding the proposed approach. Also, the concept of spurious correlation is raised and discussed. Spurious correlation results from the response DG being calculated using several independent variables that are also used to calculate predictor DGs in the DA model.

  7. 2000 CKM-triangle analysis a critical review with updated experimental inputs and theoretical parameters

    Energy Technology Data Exchange (ETDEWEB)

    Roudeau, P.; Stocchi, A. [Laboratoire de l' Accelerateur Lineaire, 91 - Orsay (France); Ciuchini, M.; Lubicz, V. [Rome Univ., INFN (Italy); D' Agostini, G.; Franco, E.; Martinelli, G. [Rome Univ. La Sapienza and Sezione INFN, (Italy); Parodi, F. [Universita di Genova and INFN, Dipt. di Fisica (Italy)

    2000-12-01

    Within the Standard Model, a review of the current determination of the sides and angles of the CKM unitarity triangle is presented, using experimental constraints from the measurements of |{epsilon}{sub K}|, |V{sub ub}/V{sub cb}|, {delta}m{sub d} and from the limit on {delta}m{sub s}, available in September 2000. Results from the experimental search for B{sup 0}{sub s}-B-bar{sup 0}{sub s} oscillations are introduced in the present analysis using the likelihood. Special attention is devoted to the determination of the theoretical uncertainties. The purpose of the analysis is to infer regions where the parameters of interest lie with given probabilities. The BaBar '95% C.L. scanning' method is also commented. (authors)

  8. Quantitative analysis of production traits in saltwater crocodiles (Crocodylus porosus): II. age at slaughter.

    Science.gov (United States)

    Isberg, S R; Thomson, P C; Nicholas, F W; Barker, S G; Moran, C

    2005-12-01

    Crocodile morphometric (head, snout-vent and total length) measurements were recorded at three stages during the production chain: hatching, inventory [average age (+/-SE) is 265.1 +/- 0.4 days] and slaughter (average age is 1037.8 +/- 0.4 days). Crocodile skins are used for the manufacture of exclusive leather products, with the most common-sized skin sold having 35-45 cm in belly width. One of the breeding objectives for inclusion into a multitrait genetic improvement programme for saltwater crocodiles is the time taken for a juvenile to reach this size or age at slaughter. A multivariate restricted maximum likelihood analysis provided (co)variance components for estimating the first published genetic parameter estimates for these traits. Heritability (+/-SE) estimates for the traits hatchling snout-vent length, inventory head length and age at slaughter were 0.60 (0.15), 0.59 (0.12) and 0.40 (0.10) respectively. There were strong negative genetic (-0.81 +/- 0.08) and phenotypic (-0.82 +/- 0.02) correlations between age at slaughter and inventory head length.

  9. Isotopic composition analysis and age dating of uranium samples by high resolution gamma ray spectrometry

    Science.gov (United States)

    Apostol, A. I.; Pantelica, A.; Sima, O.; Fugaru, V.

    2016-09-01

    Non-destructive methods were applied to determine the isotopic composition and the time elapsed since last chemical purification of nine uranium samples. The applied methods are based on measuring gamma and X radiations of uranium samples by high resolution low energy gamma spectrometric system with planar high purity germanium detector and low background gamma spectrometric system with coaxial high purity germanium detector. The "Multigroup γ-ray Analysis Method for Uranium" (MGAU) code was used for the precise determination of samples' isotopic composition. The age of the samples was determined from the isotopic ratio 214Bi/234U. This ratio was calculated from the analyzed spectra of each uranium sample, using relative detection efficiency. Special attention is paid to the coincidence summing corrections that have to be taken into account when performing this type of analysis. In addition, an alternative approach for the age determination using full energy peak efficiencies obtained by Monte Carlo simulations with the GESPECOR code is described.

  10. Reference-based combined deterministic stochastic subspace identification for experimental and operational modal analysis

    Science.gov (United States)

    Reynders, Edwin; Roeck, Guido De

    2008-04-01

    The modal analysis of mechanical or civil engineering structures consists of three steps: data collection, system identification and modal parameter estimation. The system identification step plays a crucial role in the quality of the modal parameters, that are derived from the identified system model, as well as in the number of modal parameters that can be determined. This explains the increasing interest in sophisticated system identification methods for both experimental and operational modal analysis. In purely operational or output-only modal analysis, absolute scaling of the obtained mode shapes is not possible and the frequency content of the ambient forces could be narrow banded so that only a limited number of modes are obtained. This drives the demand for system identification methods that take both artificial and ambient excitation into account so that the amplitude of the artificial excitation can be small compared to that of the ambient excitation. An accurate, robust and efficient system identification method that meets this requirements is combined deterministic-stochastic subspace identification. It can be used both for experimental modal analysis and for operational modal analysis with deterministic inputs. In this paper, the method is generalized to a reference-based version which is faster and, if the chosen reference outputs have the highest SNR values, more accurate than the classical algorithm. The algorithm is validated with experimental data from the Z24 bridge that overpassing the A1 highway between Bern and Zurich in Switzerland, that have been proposed as a benchmark for the assessment of system identification methods for the modal analysis of large structures. With the presented algorithm, the most complete set of modes reported so far is obtained.

  11. CFD analysis and experimental investigations towards optimizing the parameters of Ranque-Hilsch vortex tube

    OpenAIRE

    Behera, Upendra; Paul, PJ; Kasthurirengan, S; Karunanithi, R.; Ram, SN; Dinesh, K; Jacob, S

    2005-01-01

    Computational fluid dynamics (CFD) and experimental studies are conducted towards the optimization of the Ranque-Hilsch vortex tubes.Different types of nozzle profiles and number of nozzles are evaluated by CFD analysis. The swirl velocity, axial velocity and radial velocity components as well as the flow patterns including secondary circulation flow have been evaluated. The optimum cold end diameter (d(c)) and the length to diameter (L/D) ratios and optimum parameters for obtaining the maxim...

  12. Experimental Modal Analysis and Dynamic Component Synthesis. Volume 1. Summary of Technical Work

    Science.gov (United States)

    1987-12-01

    Rades. M., "Identification of the Dynamic Characteristics of a Simple System with Quadratic Damping," Serie de Mecanique Appliquee. 28 (4), 1983, pp...Measurement and Analysis Requirements," SAE Paper Number 751066 1975, 17 pp. [261 Prony, R. "Essai Experimental et Analytique sur les Lois de [a...of the Dynamic Characteristics of a Simple System with Quadratic Damping, Serie de Mecanique Appliquee, Vol. 28, Num. 4, 1983, pp. 439-446. 11391

  13. A comparative theoretical-experimental analysis of settlements of shallow foundations on granular soil

    OpenAIRE

    Davidović Nebojša; Bonić Zoran; Prolović Verka; Mladenović Biljana; Stojić Dragoslav

    2010-01-01

    The paper presents a brief description of experiment within the research project 'Theoretical and experimental analysis of interaction of shallow reinforced concrete foundations and soil for the purpose of improvement of national regulations and implementaation of Eurocode system' where in situ tests of a series of reinforced concrete foundation footing were performed, by loading until failure. As a rule, methods for calculation of shallow foundations settlement on granular soils overestimate...

  14. Numerical analysis of temperature field during hardfacing process and comparison with experimental results

    Directory of Open Access Journals (Sweden)

    Lazić Vukić N.

    2014-01-01

    Full Text Available The three-dimensional transient nonlinear thermal analysis of the hard facing process is performed by using the finite element method. The simulations were executed on the open source Salome platform using the open source finite element solver Code_Aster. The Gaussian double ellipsoid was selected in order to enable greater possibilities for the calculation of the moving heat source. The numerical results were compared with available experimental results.

  15. Docosahexaenoic acid signaling modulates cell survival in experimental ischemic stroke penumbra and initiates long-term repair in young and aged rats.

    Directory of Open Access Journals (Sweden)

    Tiffany N Eady

    Full Text Available BACKGROUND: Docosahexaenoic acid, a major omega-3 essential fatty acid family member, improves behavioral deficit and reduces infarct volume and edema after experimental focal cerebral ischemia. We hypothesize that DHA elicits neuroprotection by inducing AKT/p70S6K phosphorylation, which in turn leads to cell survival and protects against ischemic stroke in young and aged rats. METHODS AND RESULTS: Rats underwent 2 h of middle cerebral artery occlusion (MCAo. DHA, neuroprotectin D1 (NPD1 or vehicle (saline was administered 3 h after onset of stroke. Neurological function was evaluated on days 1, 2, 3, and 7. DHA treatment improved functional recovery and reduced cortical, subcortical and total infarct volumes 7 days after stroke. DHA also reduced microglia infiltration and increased the number of astrocytes and neurons when compared to vehicle on days 1 and 7. Increases in p473 AKT and p308 AKT phosphorylation/activation were observed in animals treated with DHA 4 h after MCAo. Activation of other members of the AKT signaling pathway were also observed in DHA treated animals including increases in pS6 at 4 h and pGSK at 24 h. DHA or NPD1 remarkably reduced total and cortical infarct in aged rats. Moreover, we show that in young and aged rats DHA treatment after MCAo potentiates NPD1 biosynthesis. The phosphorylation of p308 AKT or pGSK was not different between groups in aged rats. However, pS6 expression was increased with DHA or NPD1 treatment when compared to vehicle. CONCLUSIONS: We suggest that DHA induces cell survival, modulates the neuroinflammatory response and triggers long term restoration of synaptic circuits. Both DHA and NPD1 elicited remarkable protection in aged animals. Accordingly, activation of DHA signaling might provide benefits in the management of ischemic stroke both acutely as well as long term to limit ensuing disabilities.

  16. Results from an experimental trial at a Head Start center to evaluate two meal service approaches to increase fruit and vegetable intake of preschool aged children

    Directory of Open Access Journals (Sweden)

    Harnack Lisa J

    2012-04-01

    Full Text Available Abstract Background Strategies to increase fruit and vegetable consumption of preschool aged children are needed. Objectives Evaluate the independent effects of the following meal service strategies on intake of fruits and vegetables of preschool children: 1. Serving fruits and vegetables in advance of other menu items as part of traditional family style meal service; and 2. Serving meals portioned and plated by providers. Methods Fifty-three preschool aged children completed a randomized crossover experiment conducted at a Head Start center in Minneapolis, MN. Over a six week trial period each of the experimental meal service strategies (serving fruits and vegetable first and serving meals portioned by providers was implemented during lunch service for two one-week periods. Two one-week control periods (traditional family style meal service with all menu items served at once were also included over the six week trial period. Childrens lunch intake was observed as a measure of food and nutrient intake during each experimental condition. Results Fruit intake was significantly higher (p Conclusions Serving fruits in advance of other meal items may be a low cost easy to implement strategy for increasing fruit intake in young children. However, serving vegetables first does not appear to increase vegetable intake. Results provide support for current recommendations for traditional family style meal service in preschool settings.

  17. Analysis and Experimental Verification of a Linear Switched Reluctance Motor Having Special Pole Shape

    Directory of Open Access Journals (Sweden)

    N.C. Lenin

    2010-06-01

    Full Text Available In this paper, the results of a finite element analysis are carried out on new stator geometry of a three phase longitudinal flux Linear Switched Reluctance Motor (LSRM. In the new geometry, pole shoes are affixed to the stator poles. Static and dynamic characteristics for the proposed structure have been highlighted. Motor performance for variable load conditions is discussed. The 2-Dimensional (2-D finite element analysis (FEA and the experimental results of this paper prove that LSRMs are one of the strong candidates for linear propulsion drive

  18. Comprehensive experimental analysis of nonlinear dynamics in an optically-injected semiconductor laser

    Directory of Open Access Journals (Sweden)

    Kevin Schires

    2011-09-01

    Full Text Available We present the first comprehensive experimental study, to our knowledge, of the routes between nonlinear dynamics induced in a semiconductor laser under external optical injection based on an analysis of time-averaged measurements of the optical and RF spectra and phasors of real-time series of the laser output. The different means of analysis are compared for several types of routes and the benefits of each are discussed in terms of the identification and mapping of the nonlinear dynamics. Finally, the results are presented in a novel audio/video format that describes the evolution of the dynamics with the injection parameters.

  19. Experimental and Numerical Analysis of Screw Fixation in Anterior Cruciate Ligament Reconstruction

    Science.gov (United States)

    Chizari, Mahmoud; Wang, Bin; Snow, Martyn; Barrett, Mel

    2008-09-01

    This paper reports the results of an experimental and finite element analysis of tibial screw fixation in anterior cruciate ligament (ACL) reconstruction. The mechanical properties of the bone and tendon graft are obtained from experiments using porcine bone and bovine tendon. The results of the numerical study are compared with those from mechanical testing. Analysis shows that the model may be used to establish the optimum placement of the tunnel in anterior cruciate ligament reconstruction by predicting mechanical parameters such as stress, strain and displacement at regions in the tunnel wall.

  20. CFD and Experimental Analysis of a Falling Film outside Smooth and Helically Grooved Tubes

    Directory of Open Access Journals (Sweden)

    Cenk Onan

    2014-08-01

    Full Text Available Simultaneous heat and mass transfer are investigated in a falling film outside grooved and smooth tubes. A numerical analysis of the helically trapezoidal-grooved and reference smooth tube was performed in the computational fluid dynamics program “Ansys Fluent 14.” The three-dimensional model drawings in the x, y, and z coordinates are used, and the effects of the falling film outside the helically grooved tube on the surface temperature and surface heat transfer coefficient are determined. The average surface temperature, heat transfer coefficient, and Nu values are determined experimentally for a constant heat flux. An uncertainty analysis and Nu correlation for the grooved tube are also provided in this study. The Reynolds number varied between 50 and 350 for the falling film and between 1500 and 3500 for air. Using a computational fluid dynamics (CFD analysis for the reference smooth tube, the experimental results are validated within 2–12% difference. The experimental results are also within 6–13% of the grooved tubes.

  1. Computing the modal mass from the state space model in combined experimental-operational modal analysis

    Science.gov (United States)

    Cara, Javier

    2016-05-01

    Modal parameters comprise natural frequencies, damping ratios, modal vectors and modal masses. In a theoretic framework, these parameters are the basis for the solution of vibration problems using the theory of modal superposition. In practice, they can be computed from input-output vibration data: the usual procedure is to estimate a mathematical model from the data and then to compute the modal parameters from the estimated model. The most popular models for input-output data are based on the frequency response function, but in recent years the state space model in the time domain has become popular among researchers and practitioners of modal analysis with experimental data. In this work, the equations to compute the modal parameters from the state space model when input and output data are available (like in combined experimental-operational modal analysis) are derived in detail using invariants of the state space model: the equations needed to compute natural frequencies, damping ratios and modal vectors are well known in the operational modal analysis framework, but the equation needed to compute the modal masses has not generated much interest in technical literature. These equations are applied to both a numerical simulation and an experimental study in the last part of the work.

  2. Experimental and Exergy Analysis of A Double Pipe Heat Exchanger for Parallel Flow Arrangement

    Directory of Open Access Journals (Sweden)

    Parth P. Parekh

    2014-07-01

    Full Text Available This paper presents For Experimental and Exergy Analysis of a Double Pipe Heat Exchanger for Parallel- flow Arrangement. The Double pipe heat exchanger is one of the Different types of heat exchangers. double-pipe exchanger because one fluid flows inside a pipe and the other fluid flows between that pipe and another pipe that surrounds the first.In a parallel flow, both the hot and cold fluids enter the Heatexchanger at same end andmove in same direction. The present work is taken up to carry experimental work and the exergy analysis based on second law analysis of a Double-Pipe Heat Exchanger. In experimental set up hot water and cold water will be used working fluids. The inlet Hot water will be varied from 40 0C and 50 0C and cold water temperature will be varied from between 15 and 20 0C. It has been planned to find effects of the inlet condition of both working fluid flowing through the heat exchanger on the heat transfer characteristics, entropy generation, and Exergy loss. The Mathematical modelling of heat exchanger will based on the conservation equation of mass, energy and based on second law of thermodynamics to find entropy generation and exergy losses.

  3. Experimental and finite element analysis of bond-slip in reinforced concrete

    Directory of Open Access Journals (Sweden)

    A. R. V. WOLENSKI

    Full Text Available Abstract The modeling of reinforced concrete structures has taken advantage of the increasing progress on Computational Mechanics, in such way that complex phenomena, such as cracking and crushing, creep, reinforcement yielding, steel-concrete bond loss, can be modeled in a reasonable realistic way, using the proper set of numerical and computational resources. Among several options, the ones based on the Finite Element Method (FEM allow complex analysis simulations of reinforced concrete structures, including the interaction of different nonlinear effects. This paper deals with the nonlinear finite element analysis of the bond-slip between reinforcing steel and concrete, taking into account an experimental study previously performed. The FEM analysis presented uses a combination of resources where the material behavior of concrete is described by the Microplane Constitutive Model, and an embedded reinforcement model is used to represent steel inside the concrete and take into account the effect of bond-slip. The FEM models were created using the INSANE (INteractive Structural ANalysis Environment computational system, open source software that has a set of FEM tools for nonlinear analysis of reinforced concrete structures. The correlations between numerical-experimentals results and several parameters validate the proposed combination of resources and identifies the significance of various effects on the response.

  4. Experimental and Numerical Correlation of Impact of Spherical Projectile for Damage Analysis of Aero Engine Component

    Directory of Open Access Journals (Sweden)

    Anuradha Nayak Majila

    2016-03-01

    Full Text Available Studies the impact response of flat Titanium alloy plate against spherical projectile for damage analysis of aero engine components using experimental and finite element techniques. Compressed gas gun has been used to impart speed to spherical projectile at various impact velocities for damage studies. Crater dimensions (diameter and depth obtained due to impact have been compared with finite element results using commercially available explicit finite element method code LS-DYNA. Strain hardening, high strain rate and thermal softening effect along with damage parameters have been considered using modified Johnson-Cook material model of LS-DYNA. Metallographic analysis has been performed on the indented specimen. This analysis is useful to study failure analysis of gas turbine engine components subjected to domestic object damage of gas turbine engine. Defence Science Journal, Vol. 66, No. 2, March 2016, pp. 193-199, DOI: http://dx.doi.org/10.14429/dsj.66.9130

  5. Experimental determinations of soil copper toxicity to lettuce (Lactuca sativa) growth in highly different copper spiked and aged soils.

    Science.gov (United States)

    Christiansen, Karen S; Borggaard, Ole K; Holm, Peter E; Vijver, Martina G; Hauschild, Michael Z; Peijnenburg, Willie J G M

    2015-04-01

    Accurate knowledge about factors and conditions determining copper (Cu) toxicity in soil is needed for predicting plant growth in various Cu-contaminated soils. Therefore, effects of Cu on growth (biomass production) of lettuce (Lactuca sativa) were tested on seven selected, very different soils spiked with Cu and aged for 2 months at 35 °C. Cu toxicity was expressed as pEC50(Cu(2+)), i.e., the negative logarithm of the EC50(Cu(2+)) activity to plant growth. The determined pEC50(Cu(2+)) was significantly and positively correlated with both the analytically readily available soil pH and concentration of dissolved organic carbon [DOC] which together could explain 87% of the pEC50(Cu(2+)) variation according to the simple equation: pEC50(Cu(2+)) = 0.98 × pH + 345 × [DOC] - 0.27. Other soil characteristics, including the base cation concentrations (Na(+), K(+), Ca(2+), Mg(2+)), the cation exchange capacity at soil pH (ECEC), and at pH 7 (CEC7), soil organic carbon, clay content, and electric conductivity as well as the distribution coefficient (Kd) calculated as the ratio between total soil Cu and water-extractable Cu did not correlate significantly with pEC50(Cu(2+)). Consequently, Cu toxicity, expressed as the negative log of the Cu(2+) activity, to plant growth increases at increasing pH and DOC, which needs to be considered in future management of plant growth on Cu-contaminated soils. The developed regression equation allows identification of soil types in which the phytotoxicity potential of Cu is highest.

  6. Experimental research and finite element analysis of bridge piers failed in flexure-shear modes

    Institute of Scientific and Technical Information of China (English)

    Sun Zhiguo; Si Bingjun; Wang Dongsheng; Guo Xun

    2008-01-01

    In recent earthquakes,a large number of reinforced concrete (RC) bridges were severely damaged due to mixed flexure-shear failure modes of the bridge piers.An integrated experimental and finite element (FE) analysis study is described in this paper to study the seismic performance of the bridge piers that failed in flexure-shear modes.In the first part,a nonlinear cyclic loading test on six RC bridge piers with circular cross sections is carried out experimentally.The damage states,ductility and energy dissipation parameters,stiffness degradation and shear strength of the piers are studied and compared with each other.The experimental results suggest that all the piers exhibit stable flexural response at displacement ductilities up to four before exhibiting brittle shear failure.The ultimate performance of the piers is dominated by shear capacity due to significant shear cracking,and in some cases,rupturing of spiral bars.In the second part,modeling approaches describing the hysteretic behavior of the piers are investigated by using ANSYS software.A set of models with different parameters is selected and evaluated through comparison with experimental results.The influences of the shear retention coefficients between concrete cracks,the Bauschinger effect in longitudinal reinforcement,the bond-slip relationship between the longitudinal reinforcement and the concrete and the concrete failure surface on the simulated hysteretie curves are discussed.Then,a modified analysis model is presented and its accuracy is verified by comparing the simulated results with experimental ones.This research uses models available in commercial FE codes and is intended for researchers and engineers interested in using ANSYS software to predict the hysteretic behavior of reinforced concrete structures.

  7. Experimental research and finite element analysis of bridge piers failed in flexure-shear modes

    Science.gov (United States)

    Sun, Zhiguo; Si, Bingjun; Wang, Dongsheng; Guo, Xun

    2008-12-01

    In recent earthquakes, a large number of reinforced concrete (RC) bridges were severely damaged due to mixed flexure-shear failure modes of the bridge piers. An integrated experimental and finite element (FE) analysis study is described in this paper to study the seismic performance of the bridge piers that failed in flexure-shear modes. In the first part, a nonlinear cyclic loading test on six RC bridge piers with circular cross sections is carried out experimentally. The damage states, ductility and energy dissipation parameters, stiffness degradation and shear strength of the piers are studied and compared with each other. The experimental results suggest that all the piers exhibit stable flexural response at displacement ductilities up to four before exhibiting brittle shear failure. The ultimate performance of the piers is dominated by shear capacity due to significant shear cracking, and in some cases, rupturing of spiral bars. In the second part, modeling approaches describing the hysteretic behavior of the piers are investigated by using ANSYS software. A set of models with different parameters is selected and evaluated through comparison with experimental results. The influences of the shear retention coefficients between concrete cracks, the Bauschinger effect in longitudinal reinforcement, the bond-slip relationship between the longitudinal reinforcement and the concrete and the concrete failure surface on the simulated hysteretic curves are discussed. Then, a modified analysis model is presented and its accuracy is verified by comparing the simulated results with experimental ones. This research uses models available in commercial FE codes and is intended for researchers and engineers interested in using ANSYS software to predict the hysteretic behavior of reinforced concrete structures.

  8. Experimental and theoretical oscillator strengths of Mg i for accurate abundance analysis

    Science.gov (United States)

    Pehlivan Rhodin, A.; Hartman, H.; Nilsson, H.; Jönsson, P.

    2017-02-01

    Context. With the aid of stellar abundance analysis, it is possible to study the galactic formation and evolution. Magnesium is an important element to trace the α-element evolution in our Galaxy. For chemical abundance analysis, such as magnesium abundance, accurate and complete atomic data are essential. Inaccurate atomic data lead to uncertain abundances and prevent discrimination between different evolution models. Aims: We study the spectrum of neutral magnesium from laboratory measurements and theoretical calculations. Our aim is to improve the oscillator strengths (f-values) of Mg i lines and to create a complete set of accurate atomic data, particularly for the near-IR region. Methods: We derived oscillator strengths by combining the experimental branching fractions with radiative lifetimes reported in the literature and computed in this work. A hollow cathode discharge lamp was used to produce free atoms in the plasma and a Fourier transform spectrometer recorded the intensity-calibrated high-resolution spectra. In addition, we performed theoretical calculations using the multiconfiguration Hartree-Fock program ATSP2K. Results: This project provides a set of experimental and theoretical oscillator strengths. We derived 34 experimental oscillator strengths. Except from the Mg i optical triplet lines (3p 3P°0,1,2-4s 3S1), these oscillator strengths are measured for the first time. The theoretical oscillator strengths are in very good agreement with the experimental data and complement the missing transitions of the experimental data up to n = 7 from even and odd parity terms. We present an evaluated set of oscillator strengths, gf, with uncertainties as small as 5%. The new values of the Mg i optical triplet line (3p 3P°0,1,2-4s 3S1) oscillator strength values are 0.08 dex larger than the previous measurements.

  9. Analysis of transpacific transport of black carbon during HIPPO-3: implications for black carbon aging

    Directory of Open Access Journals (Sweden)

    Z. Shen

    2014-01-01

    Full Text Available Long-range transport of black carbon (BC is a growing concern as a result of the efficiency of BC in warming the climate and its adverse impact on human health. We study transpacific transport of BC during HIPPO-3 using a combination of inverse modeling and sensitivity analysis. We use the GEOS-Chem chemical transport model and its adjoint to constrain Asian BC emissions and estimate the source of BC over the North Pacific. We find that different sources of BC dominate the transport to the North Pacific during the southbound (29 March 2010 and northbound (13 April 2010 measurements in HIPPO-3. While biomass burning in Southeast Asia (SE contributes about 60% of BC in March, more than 90% of BC comes from fossil fuel and biofuel combustion in East Asia (EA during the April mission. GEOS-Chem simulations generally resolve the spatial and temporal variation of BC concentrations over the North Pacific, but are unable to reproduce the low and high tails of the observed BC distribution. We find that the optimized BC emissions derived from inverse modeling fail to improve model simulations significantly. This failure indicates that uncertainties in BC transport, rather than in emissions, account for the major biases in GEOS-Chem simulations of BC. The aging process, transforming BC from hydrophobic into hydrophilic form, is one of the key factors controlling wet scavenging and remote concentrations of BC. Sensitivity tests on BC aging suggest that the aging time scale of anthropogenic BC from EA is several hours, faster than assumed in most global models, while the aging process of biomass burning BC from SE may occur much slower, with a time scale of a few days. To evaluate the effects of BC aging and wet deposition on transpacific transport of BC, we develop an idealized model of BC transport. We find that the mid-latitude air masses sampled during HIPPO-3 may have experienced a series of precipitation events, particularly near the EA and SE source

  10. Protocol for an experimental investigation of the roles of oxytocin and social support in neuroendocrine, cardiovascular, and subjective responses to stress across age and gender

    Directory of Open Access Journals (Sweden)

    Block Jason

    2009-12-01

    Full Text Available Abstract Background Substantial empirical evidence has demonstrated that individuals who are socially isolated or have few positive social connections seem to age at a faster rate and have more chronic diseases. Oxytocin is a neurohypophyseal hormone hypothesized to coordinate both the causes and effects of positive social interactions, and may be involved in positive physiological adaptations such as buffering the deleterious effects of stress and promoting resilience. The proposed research will examine whether and how oxytocin influences responses to stress in humans and will consider effects in relation to those of social support. Methods/Design Experimental research will be used to determine whether exogenously administered oxytocin (intranasal influences psychological and physiological outcomes under conditions of stress across gender and age in adulthood. Hypotheses to be tested are: 1 Oxytocin ameliorates the deleterious neuroendocrine, cardiovascular, and subjective effects of stress; 2 Oxytocin and social support have similar and additive stress-buffering effects; 3 Oxytocin effects are stronger in women versus men; and 4 Oxytocin effects are similar across a range of adult ages. Hypotheses will be tested with a placebo-controlled, double-blind study using a sample of healthy men and women recruited from the community. Participants are randomly assigned to receive either oxytocin or placebo. They undergo a social stress manipulation with and without social support (randomly assigned, and outcome measures are obtained at multiple times during the procedure. Discussion Understanding the determinants of healthy aging is a major public health priority and identifying effective measures to prevent or delay the onset of chronic diseases is an important goal. Experimental research on oxytocin, social relationships, and health in adulthood will contribute to the scientific knowledge base for maximizing active life and health expectancy. At

  11. Modern Attitudes Toward Older Adults in the Aging World: A Cross-Cultural Meta-Analysis.

    Science.gov (United States)

    North, Michael S; Fiske, Susan T

    2015-09-01

    Prevailing beliefs suggest that Eastern cultures hold older adults in higher esteem than Western cultures do, due to stronger collectivist traditions of filial piety. However, in modern, industrialized societies, the strain presented by dramatic rises in population aging potentially threatens traditional cultural expectations. Addressing these competing hypotheses, a literature search located 37 eligible papers, comprising samples from 23 countries and 21,093 total participants, directly comparing Easterners and Westerners (as classified per U.N. conventions) in their attitudes toward aging and the aged. Contradicting conventional wisdom, a random-effects meta-analysis on these articles found such evaluations to be more negative in the East overall (standardized mean difference = -0.31). High heterogeneity in study comparisons suggested the presence of moderators; indeed, geographical region emerged as a significant moderating factor, with the strongest levels of senior derogation emerging in East Asia (compared with South and Southeast Asia) and non-Anglophone Europe (compared with North American and Anglophone Western regions). At the country level, multiple-moderator meta-regression analysis confirmed recent rises in population aging to significantly predict negative elder attitudes, controlling for industrialization per se over the same time period. Unexpectedly, these analyses also found that cultural individualism significantly predicted relative positivity-suggesting that, for generating elder respect within rapidly aging societies, collectivist traditions may backfire. The findings suggest the importance of demographic challenges in shaping modern attitudes toward elders-presenting considerations for future research in ageism, cross-cultural psychology, and even economic development, as societies across the globe accommodate unprecedented numbers of older citizens.

  12. Residual stress analysis in aged graphite/PMR-15 composites using X-ray diffraction

    Energy Technology Data Exchange (ETDEWEB)

    Benedikt, B. [Los Alamos National Laboratory, Engineering Sciences and Applications Division, Los Alamos, NM 87545 (United States)]. E-mail: bbenedikt@lanl.gov; Lewis, M. [Los Alamos National Laboratory, Engineering Sciences and Applications Division, Los Alamos, NM 87545 (United States); Rangaswamy, P. [Los Alamos National Laboratory, Engineering Sciences and Applications Division, Los Alamos, NM 87545 (United States); Kumosa, M. [Center for Advanced Materials and Structures, Department of Engineering, University of Denver, 2390 South York St., Denver, CO 80208 (United States); Predecki, P. [Center for Advanced Materials and Structures, Department of Engineering, University of Denver, 2390 South York St., Denver, CO 80208 (United States); Kumosa, L. [Center for Advanced Materials and Structures, Department of Engineering, University of Denver, 2390 South York St., Denver, CO 80208 (United States); Gentz, M. [Center for Advanced Materials and Structures, Department of Engineering, University of Denver, 2390 South York St., Denver, CO 80208 (United States)

    2006-04-15

    In this paper, we present and discuss the methodology to monitor average residual stresses in aged high temperature unidirectional and woven graphite fiber/PMR-15 composites. The aging experiments were performed at 315 deg. C for 1170 h in nitrogen and 1064 h in air, respectively. The proposed methodology was based on X-ray diffraction (XRD) strain measurements in embedded crystalline metallic inclusions. The aging experiments performed in nitrogen showed an increasing trend in the measured residual stresses from the embedded inclusions with aging time. In contrast, the aging experiments performed in air showed an increasing trend up to {approx}200 h and then dropped by {approx}40% for both unidirectional and woven composites. To extract the average stresses in the composite matrix from the average stresses in embedded inclusions as determined using XRD, the well-established Eshelby/Mori-Tanaka method was used. In addition, to address the effect of inclusion interactions, we also computed the average stresses in the embedded inclusions by taking into account inclusion interactions within the frame-work of the Eshelby/Mori-Tanaka method. It was shown that the interactions between the inclusions did not significantly disturb the average stresses in the inclusions, thereby validating the Eshelby/Mori-Tanaka method used in our analysis. Finally, we show that for an aging process that does not cause any damage to a composite matrix, a relatively simple computation based on the visco-elastic Eshelby/Mori-Tanaka method is sufficient to determine the average stress field in a composite matrix as compared with the predictions based on classical lamination plate theory (CLPT). However, if significant matrix degradation occurs, the current micromechanical modeling approach would likely produce erroneous results.

  13. Analysis of the standing age distribution and age-specific recruitment rate of the George River and Beverly barren-ground caribou populations

    Directory of Open Access Journals (Sweden)

    M. Taylor

    1991-10-01

    Full Text Available The primary advantage of the standing age distribution of a population is that it can be sampled. Analysis of the age frequencies for estimates of survival rates and determinations of population status by life table construction depend heavily on assumption that require additional data to evaluate. The analysis of age structures for the George River (Messier et al., 1988 and Beverly (Thomas and Barry, 1990a,b caribou herd was reviewed. An alternativ method of estimating age specific survival rates was explored. The dependence of the life tables produced by the analysis of Messier et al. (1988 and Thomas and Barry (1990a,b on tenuous and untestable assumptions regarding population growth rate over the life span of the oldest animals, stability of the standing age distribution, and constancy of life table parameters was emphasized. Although the life tables produced by Messier et al. (1988 for the George River herd and Thomas and Barry (1990a,b for the Beverly herd are probably the best available for barren-ground caribou, they should be used with caution, particularly for management decisions.

  14. Gender role affects experimental pain responses: a systematic review with meta-analysis.

    Science.gov (United States)

    Alabas, O A; Tashani, O A; Tabasam, G; Johnson, M I

    2012-10-01

    Gender role refers to the culturally and socially constructed meanings that describe how women and men should behave in certain situations according to feminine and masculine roles learned throughout life. The aim of this meta-analysis was to evaluate the relationship between gender role and experimental pain responses in healthy human participants. We searched computerized databases for studies published between January 1950 and May 2011 that had measured gender role in healthy human adults and pain response to noxious stimuli. Studies were entered into a meta-analysis if they calculated a correlation coefficient (r) for gender role and experimental pain. Searches yielded 4465 'hits' and 13 studies were eligible for review. Sample sizes were 67-235 participants and the proportion of female participants was 45-67%. Eight types of gender role instrument were used. Meta-analysis of six studies (406 men and 539 women) found a significant positive correlation between masculine and feminine personality traits and pain threshold and tolerance, with a small effect size (r = 0.17, p = 0.01). Meta-analysis of four studies (263 men and 297 women) found a significant negative correlation between gender stereotypes specific to pain and pain threshold and tolerance, with a moderate effect size (r = -0.41, p pain than the typical man showed higher pain thresholds and tolerances. Gender stereotypes specific to pain scales showed stronger associations with sex differences in pain sensitivity response than masculine and feminine personality trait scales.

  15. Updating Finite Element Model of a Wind Turbine Blade Section Using Experimental Modal Analysis Results

    Directory of Open Access Journals (Sweden)

    Marcin Luczak

    2014-01-01

    Full Text Available This paper presents selected results and aspects of the multidisciplinary and interdisciplinary research oriented for the experimental and numerical study of the structural dynamics of a bend-twist coupled full scale section of a wind turbine blade structure. The main goal of the conducted research is to validate finite element model of the modified wind turbine blade section mounted in the flexible support structure accordingly to the experimental results. Bend-twist coupling was implemented by adding angled unidirectional layers on the suction and pressure side of the blade. Dynamic test and simulations were performed on a section of a full scale wind turbine blade provided by Vestas Wind Systems A/S. The numerical results are compared to the experimental measurements and the discrepancies are assessed by natural frequency difference and modal assurance criterion. Based on sensitivity analysis, set of model parameters was selected for the model updating process. Design of experiment and response surface method was implemented to find values of model parameters yielding results closest to the experimental. The updated finite element model is producing results more consistent with the measurement outcomes.

  16. Experimental design and instability analysis of coaxial electrospray process for microencapsulation of drugs and imaging agents.

    Science.gov (United States)

    Si, Ting; Zhang, Leilei; Li, Guangbin; Roberts, Cynthia J; Yin, Xiezhen; Xu, Ronald

    2013-07-01

    Recent developments in multimodal imaging and image-guided therapy requires multilayered microparticles that encapsulate several imaging and therapeutic agents in the same carrier. However, commonly used microencapsulation processes have multiple limitations such as low encapsulation efficiency and loss of bioactivity for the encapsulated biological cargos. To overcome these limitations, we have carried out both experimental and theoretical studies on coaxial electrospray of multilayered microparticles. On the experimental side, an improved coaxial electrospray setup has been developed. A customized coaxial needle assembly combined with two ring electrodes has been used to enhance the stability of the cone and widen the process parameter range of the stable cone-jet mode. With this assembly, we have obtained poly(lactide-co-glycolide) microparticles with fine morphology and uniform size distribution. On the theoretical side, an instability analysis of the coaxial electrified jet has been performed based on the experimental parameters. The effects of process parameters on the formation of different unstable modes have been studied. The reported experimental and theoretical research represents a significant step toward quantitative control and optimization of the coaxial electrospray process for microencapsulation of multiple drugs and imaging agents in multimodal imaging and image-guided therapy.

  17. Modal analysis of the SCALPEL mask using experimental and numerical methods

    Science.gov (United States)

    Semke, William H.; Schlax, Michael P.; Engelstad, Roxann L.; Lovell, Edward G.; Liddle, James A.

    1999-06-01

    Controlling the dynamic response of the SCALPEL mask is important to ensure high throughput consistent with the stringent error budgets allocated for sub-130 nm lithography. In this paper experimental and numerical modal analysis result for the SCALPEL mask are presented and compared. These experimental result are used to verify and benchmark the finite element modeling efforts. The mode shapes and their respective frequencies provide valuable information for characterizing the out-of-plane and in-plane oscillations of the mask. The out-of-plane mode shapes were found experimentally with the use of both a Zygo interferometer and a Polytec scanning laser vibrometer. An additional application for out-of-plane oscillations involves a SCALPEL mask cleaning procedure, called the PLAMAX process, where the mask is resonated at its natural frequencies while surface particles are electrostatically charged in the present of a plasma and removed. The in-plane vibrations of the SCALPEL mask have also been investigated, since this is the primary excitation mode of the mask during exposure stepping. For experimental data, the in-plane modes were excited mechanically and detected using a MTI Fotonic sensor fiber-optic probe.

  18. The probabilistic analysis of language acquisition: Theoretical, computational, and experimental analysis

    CERN Document Server

    Hsu, Anne S; Vitanyi, Paul M B

    2010-01-01

    There is much debate over the degree to which language learning is governed by innate language-specific biases, or acquired through cognition-general principles. Here we examine the probabilistic language acquisition hypothesis on three levels: We outline a novel theoretical result showing that it is possible to learn the exact generative model underlying a wide class of languages, purely from observing samples of the language. We then describe a recently proposed practical framework, which quantifies natural language learnability, allowing specific learnability predictions to be made for the first time. In previous work, this framework was used to make learnability predictions for a wide variety of linguistic constructions, for which learnability has been much debated. Here, we present a new experiment which tests these learnability predictions. We find that our experimental results support the possibility that these linguistic constructions are acquired probabilistically from cognition-general principles.

  19. Morbility, clinical data and proteomic analysis of IUGR and AGA newborns at different gestational ages

    Directory of Open Access Journals (Sweden)

    M.D. Ruiz-González

    2016-12-01

    Full Text Available The data are related to the proteomic analysis of 43 newborns with intrauterine growth retardation (IUGR and 45 newborns with appropriate weight for gestational age (AGA carried out by separation via 2DE and analyzed by MS–TOF/TOF. All newborns were separated into three gestational age groups, "Very Preterm" 29–32 weeks, "Moderate Preterm" 33–36 weeks, and, "Term" ≥37weeks. From each newborn, blood was drawn three times from birth to 1 month life. High-abundant serum proteins were depleted, and the minority ones were separated by 2DE and analyzed for significant expression differences. The data reflect analytic and clinic variables analyzed globally and categorized by gestational age in relation to IUGR and the optimization of conditions for 2-DE separation. The data from this study are related to the research article entitled "Alterations of Protein Expression in Serum of Infants with Intrauterine Growth Restriction and Different Gestational Ages" (M.D. Ruis-González, M.D. Cañete, J.L. Gómez-Chaparro, N. Abril, R. Cañete, J. López-Barea, 2015 [1]. The present dataset of serum IUGR newborn proteome can be used as a reference for any study involving intrauterine growth restriction during the first month of life.

  20. Meta-analysis of loci associated with age at natural menopause in African-American women.

    Science.gov (United States)

    Chen, Christina T L; Liu, Ching-Ti; Chen, Gary K; Andrews, Jeanette S; Arnold, Alice M; Dreyfus, Jill; Franceschini, Nora; Garcia, Melissa E; Kerr, Kathleen F; Li, Guo; Lohman, Kurt K; Musani, Solomon K; Nalls, Michael A; Raffel, Leslie J; Smith, Jennifer; Ambrosone, Christine B; Bandera, Elisa V; Bernstein, Leslie; Britton, Angela; Brzyski, Robert G; Cappola, Anne; Carlson, Christopher S; Couper, David; Deming, Sandra L; Goodarzi, Mark O; Heiss, Gerardo; John, Esther M; Lu, Xiaoning; Le Marchand, Loic; Marciante, Kristin; Mcknight, Barbara; Millikan, Robert; Nock, Nora L; Olshan, Andrew F; Press, Michael F; Vaiyda, Dhananjay; Woods, Nancy F; Taylor, Herman A; Zhao, Wei; Zheng, Wei; Evans, Michele K; Harris, Tamara B; Henderson, Brian E; Kardia, Sharon L R; Kooperberg, Charles; Liu, Yongmei; Mosley, Thomas H; Psaty, Bruce; Wellons, Melissa; Windham, Beverly G; Zonderman, Alan B; Cupples, L Adrienne; Demerath, Ellen W; Haiman, Christopher; Murabito, Joanne M; Rajkovic, Aleksandar

    2014-06-15

    Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders. GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated with age at menopause. The relevance of these loci to women of African ancestry has not been previously studied. We therefore sought to uncover additional menopause loci and investigate the relevance of European menopause loci by performing a GWAS meta-analysis in 6510 women with African ancestry derived from 11 studies across the USA. We did not identify any additional loci significantly associated with age at menopause in African Americans. We replicated the associations between six loci and age at menopause (P-value < 0.05): AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8. In addition, associations of 14 loci are directionally consistent with previous reports. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in women of African ancestry residing in USA.

  1. An analysis of the size distribution of Italian firms by age

    Science.gov (United States)

    Cirillo, Pasquale

    2010-02-01

    In this paper we analyze the size distribution of Italian firms by age. In other words, we want to establish whether the way that the size of firms is distributed varies as firms become old. As a proxy of size we use capital. In [L.M.B. Cabral, J. Mata, On the evolution of the firm size distribution: Facts and theory, American Economic Review 93 (2003) 1075-1090], the authors study the distribution of Portuguese firms and they find out that, while the size distribution of all firms is fairly stable over time, the distributions of firms by age groups are appreciably different. In particular, as the age of the firms increases, their size distribution on the log scale shifts to the right, the left tails becomes thinner and the right tail thicker, with a clear decrease of the skewness. In this paper, we perform a similar analysis with Italian firms using the CEBI database, also considering firms’ growth rates. Although there are several papers dealing with Italian firms and their size distribution, to our knowledge a similar study concerning size and age has not been performed yet for Italy, especially with such a big panel.

  2. Polarized light scanning cryomacroscopy, part II: Thermal modeling and analysis of experimental observations.

    Science.gov (United States)

    Feig, Justin S G; Solanki, Prem K; Eisenberg, David P; Rabin, Yoed

    2016-10-01

    This study aims at developing thermal analysis tools and explaining experimental observations made by means of polarized-light cryomacroscopy (Part I). Thermal modeling is based on finite elements analysis (FEA), where two model parameters are extracted from thermal measurements: (i) the overall heat transfer coefficient between the cuvette and the cooling chamber, and (ii) the effective thermal conductivity within the cryoprotective agent (CPA) at the upper part of the cryogenic temperature range. The effective thermal conductivity takes into account enhanced heat transfer due to convection currents within the CPA, creating the so-called Bénard cells. Comparison of experimental results with simulation data indicates that the uncertainty in simulations due to the propagation of uncertainty in measured physical properties exceeds the uncertainty in experimental measurements, which validates the modeling approach. It is shown in this study that while a cavity may form in the upper-center portion of the vitrified CPA, it has very little effect on estimating the temperature distribution within the domain. This cavity is driven by thermal contraction of the CPA, with the upper-center of the domain transitioning to glass last. Finally, it is demonstrated in this study that additional stresses may develop within the glass transition temperature range due to nonlinear behavior of the thermal expansion coefficient. This effect is reported here for the first time in the context of cryobiology, using the capabilities of polarized-light cryomacroscopy.

  3. Experimental and numerical analysis of unsteady behaviour of high efficiency mixed-flow pump

    Directory of Open Access Journals (Sweden)

    Sedlář Milan

    2014-03-01

    Full Text Available This work deals with the experimental and numerical investigation of cavitating and noncavitating flow inside a mixed-flow pump and its influence on performance curves of this pump. The experimental research has been carried out in the closed horizontal loop with the main tank capacity of 35 m3. The loop is equipped with both the compressor and the vacuum pump capable of creating different pressure levels while maintaining constant volume flow rate. Pump investigated in this project has been equipped with transparent windows, which enabled the visualization of flow and cavitation phenomena for a wide range of flow conditions. A comprehensive CFD analysis of tested pump has been done both in the cavitating and noncavitating regimes. The ANSYS CFX commercial CFD package has been used to solve URANS equations together with the Rayleigh-Plesset model and the SST-SAS turbulence model. Both the experimental research and the CFD analysis have provided a good illustration of the flow structures inside the pump and their dynamics for a wide range of flow rates and NPSH values. Flow and cavitation instabilities have been detected at suboptimal flow rates which correspond to increased values of noise and vibrations. The calculated results agree well with the measurements.

  4. RNA-seq Data: Challenges in and Recommendations for Experimental Design and Analysis.

    Science.gov (United States)

    Williams, Alexander G; Thomas, Sean; Wyman, Stacia K; Holloway, Alisha K

    2014-10-01

    RNA-seq is widely used to determine differential expression of genes or transcripts as well as identify novel transcripts, identify allele-specific expression, and precisely measure translation of transcripts. Thoughtful experimental design and choice of analysis tools are critical to ensure high-quality data and interpretable results. Important considerations for experimental design include number of replicates, whether to collect paired-end or single-end reads, sequence length, and sequencing depth. Common analysis steps in all RNA-seq experiments include quality control, read alignment, assigning reads to genes or transcripts, and estimating gene or transcript abundance. Our aims are two-fold: to make recommendations for common components of experimental design and assess tool capabilities for each of these steps. We also test tools designed to detect differential expression, since this is the most widespread application of RNA-seq. We hope that these analyses will help guide those who are new to RNA-seq and will generate discussion about remaining needs for tool improvement and development.

  5. Bi-functionally Graded Electrode Supported SOFC Modeling and Computational Thermal Fluid Analysis for Experimental Design

    Energy Technology Data Exchange (ETDEWEB)

    Shi, J.; Xue, X.

    2011-01-01

    A comprehensive 3D CFD model is developed for a bi-electrode supported cell (BSC) SOFC. The model includes complicated transport phenomena of mass/heat transfer, charge (electron and ion) migration, and electrochemical reaction. The uniqueness of the modeling study is that functionally graded porous electrode property is taken into account, including not only linear but nonlinear porosity distributions. Extensive numerical analysis is performed to elucidate the effects of both porous microstructure distributions and operating condition on cell performance. Results indicate that cell performance is strongly dependent on both operating conditions and porous microstructure distributions of electrodes. Using the proposed fuel/gas feeding design, the uniform hydrogen distribution within porous anode is achieved; the oxygen distribution within the cathode is dependent on porous microstructure distributions as well as pressure loss conditions. Simulation results show that fairly uniform temperature distribution can be obtained with the proposed fuel/gas feeding design. The modeling results can be employed to guide experimental design of BSC test and provide pre-experimental analysis, as a result, to circumvent high cost associated with try-and-error experimental design and setup.

  6. Experimental and numerical analysis of unsteady behaviour of high efficiency mixed-flow pump

    Science.gov (United States)

    Sedlář, Milan; Komárek, Martin; Vyroubal, Michal; Doubrava, Vít; Varchola, Michal; Hlbočan, Peter

    2014-03-01

    This work deals with the experimental and numerical investigation of cavitating and noncavitating flow inside a mixed-flow pump and its influence on performance curves of this pump. The experimental research has been carried out in the closed horizontal loop with the main tank capacity of 35 m3. The loop is equipped with both the compressor and the vacuum pump capable of creating different pressure levels while maintaining constant volume flow rate. Pump investigated in this project has been equipped with transparent windows, which enabled the visualization of flow and cavitation phenomena for a wide range of flow conditions. A comprehensive CFD analysis of tested pump has been done both in the cavitating and noncavitating regimes. The ANSYS CFX commercial CFD package has been used to solve URANS equations together with the Rayleigh-Plesset model and the SST-SAS turbulence model. Both the experimental research and the CFD analysis have provided a good illustration of the flow structures inside the pump and their dynamics for a wide range of flow rates and NPSH values. Flow and cavitation instabilities have been detected at suboptimal flow rates which correspond to increased values of noise and vibrations. The calculated results agree well with the measurements.

  7. Age differences in the effect of framing on risky choice: A meta-analysis.

    Science.gov (United States)

    Best, Ryan; Charness, Neil

    2015-09-01

    The framing of decision scenarios in terms of potential gains versus losses has been shown to influence choice preferences between sure and risky options. Normative cognitive changes associated with aging have been known to affect decision making, which has led to a number of studies investigating the influence of aging on the effect of framing. Mata, Josef, Samanez-Larkin, and Hertwig (2011) systematically reviewed the available literature using a meta-analytic approach, but did not include tests of homogeneity or subsequent moderator variable analyses. The current review serves to extend the previous analysis to include such tests as well as update the pool of studies available for analysis. Results for both positively and negatively framed conditions were reviewed using 2 meta-analyses encompassing data collected from 3,232 subjects across 18 studies. Deviating from the previous results, the current analysis found a tendency for younger adults to choose the risky option more often than older adults for positively framed items. Moderator variable analyses found this effect likely to be driven by the specific decision scenario, showing a significant effect, with younger adults choosing the risky option more often in small-amount financial and large-amount mortality-based scenarios. For negatively framed items, the current review found no overall age difference in risky decision making, confirming the results from the prior meta-analysis. Moderator variable analyses conducted to address heterogeneity found younger adults to be more likely than older adults to choose the risky option for negatively framed high-amount mortality-based decision scenarios. Practical implications for older adults are discussed.

  8. Analysis of the degradation and aging of a commercial photovoltaic installation

    Science.gov (United States)

    Bradley, Alexander; Hamzavy, Babak; Gambogi, William

    2014-10-01

    Simple and accurate methods are needed to monitor and assess PV systems. It is important to characterize and understand the value of the system with regard to safety and performance (including seasonal and geographical variations) as well as operation and maintenance. This documentation is becoming necessary for the secondary or resale value of PV assets. We report the results from an analysis of a commercial c-Si PV array owned and operated by DuPont. Our technical assessment consists of remote monitoring, field inspection with visual examination and thermal imaging to create a pareto chart of degradation modes, and laboratory analysis. A comparison of remote monitoring and site inspection is presented as well as laboratory analysis (nondestructive and destructive test methods) of modules removed from the service environment. Degradation modes and quality issues became evident as electrical, optical, physical or chemical defects developed with system age. This evaluation provided system data, documented quality issues, and quantified the cost of ownership.

  9. CFD Analysis of Experimental Wing and Winglet for FalconLAUNCH 8 and the ExFIT Program

    Science.gov (United States)

    2010-03-01

    CFD Analysis of Experimental Wing and Winglet for FalconLAUNCH 8 and the ExFIT Program THESIS Benjamin P. Switzer, Second Lieutenant, USAF AFIT/GAE...to copyright protection in the United States. AFIT/GAE/ENY/10-M25 CFD Analysis of Experimental Wing and Winglet for FalconLAUNCH 8 and the ExFIT...this analysis focused on the effects caused by shock waves forming on the winglet and their impact on the lifting characteristics and temperature

  10. Numerical and experimental analysis of the directional stability on crack propagation under biaxial stresses

    Energy Technology Data Exchange (ETDEWEB)

    RodrIguez-MartInez, R; Urriolagoitia-Calderon, G; Urriolagoitia-Sosa, G; Hernandez-Gomez, L H [Instituto Politecnico Nacional Seccion de Estudios de Posgrado e Investigacion (SEPI), Escuela Superior de IngenierIa Mecanica y Electrica (ESIME), Edificio 5. 2do Piso, Unidad Profesional Adolfo Lopez Mateos ' Zacatenco' Col. Lindavista, C.P. 07738, Mexico, D.F. (Mexico); Merchan-Cruz, E A; RodrIguez-Canizo, R G; Sandoval-Pineda, J M, E-mail: rrodriguezm@ipn.m, E-mail: urrio332@hotmail.co, E-mail: guiurri@hotmail.co, E-mail: luishector56@hotmail.co, E-mail: eamerchan@gmail.co, E-mail: ricname@hotmail.co, E-mail: jsandovalp@ipn.m [Instituto Politecnico Nacional Seccion de Estudios de Posgrado e Investigacion (SEPI), Escuela Superior de IngenierIa Mecanica y Electrica (ESIME). Unidad profesional, AZCAPOTZALCO, Av. de las Granjas No. 682, Col. Sta. Catarina Azcapotzalco, C.P. 02550, Mexico D.F. (Mexico)

    2009-08-01

    In this paper, the case of Single Edge Notch (SEN) specimens subject to opening/compressive loading was analyzed; The loads are applied in several ratios to evaluate the influence of the specimen geometry, and the Stress Intensity Factor (SIF) K{sub 1} values on the directional stability of crack propagation. The main purpose of this work is to evaluate the behaviour of the fracture propagation, when modifying the geometry of the SEN specimen and different relationships of load tension/compression are applied. Additionally, the precision of the numerical and experimental analysis is evaluated to determine its reliability when solving this type of problems. The specimens are subjected to biaxial opening/compression loading; both results (numerical and experimental) are compared in order to evaluate the condition of directional stability on crack propagation. Finally, an apparent transition point related to the length of specimens was identified, in which the behaviour of values of SIF changes for different loading ratios.

  11. Analysis of experimental data for the nucleation rate of water droplets

    Science.gov (United States)

    Kashchiev, Dimo

    2006-07-01

    A formula for the stationary nucleation rate J is proposed and used for analysis of experimental data for the dependence of J on the supersaturation ratio S in isothermal homogeneous nucleation of water droplets in vapors. It is found that the experimental data are described quite successfully by the proposed formula which is based on (i) the Gibbs presentation of the nucleation work in terms of overpressure, (ii) the Girshick-Chiu [J. Chem. Phys. 93, 1273 (1990); 94, 826 (1991)] self-consistency correction to the equilibrium cluster size distribution, and (iii) the Reguera-Rubi [J. Chem. Phys. 115, 7100 (2001)] kinetic accounting of the nucleus translational-rotational motion. The formula, like that of Wölk and Strey [J. Phys. Chem. B 105, 11683 (2001)], could be used as a semiempirical relation describing the J(S ) dependence for nucleation in vapors of single-component droplets or crystals of substances with insufficiently well known equations of state.

  12. Experimental analysis and evaluation of the mass transfer process in a trickle-bed reactor

    Directory of Open Access Journals (Sweden)

    Silva J.D.

    2003-01-01

    Full Text Available A transient experimental analysis of a three-phase descendent-cocurrent trickle-bed H2O/CH4-Ar/g -Al2O3 system was made using the stimulus-response technique, with the gas phase as a reference. Methane was used as a tracer and injected into the argon feed and the concentration vs time profiles were obtained at the entrance and exit of the bed, which were maintained at 298K and 1.013 10(5 Pa. A mathematical model for the tracer was developed to estimate the axial dispersion overall gas-liquid mass transfer and liquid-solid mass transfer coefficients. Experimental and theoretical results were compared and shown to be in good agreement. The model was validated by two additional experiments, and the values of the coefficients obtained above were confirmed.

  13. Experimental and numerical analysis of secondary disasters induced by oxygen rich combustion within a tunnel

    Institute of Scientific and Technical Information of China (English)

    Cheng Caixia; Sun Fuchun; Zhou Xinquan; Niu Huiyong; Liang De

    2011-01-01

    Various physical parameters,including gas concentrations (O2,CO,CH4,and H2) and temperatures at different air velocities,were determined for full scale wood fires in the Chongqing Coal Research Institute fire test tunnel.Both experimental measurements and numerical simulations are discussed.The numerical analysis was performed with the computational fluid dynamics software package “FLUENT”.The results show that the experimental data agree with the simulation results.The results verify that Roberts'theory of burning is correct.They also prove that the air velocity is the key factor that determines the type of combustion.Also,it is shown that secondary disasters are unlikely for oxygen rich combustion with a limited fire load.

  14. FEM Analysis of Spring-backs in Age Forming of Aluminum Alloy Plates

    Institute of Scientific and Technical Information of China (English)

    Huang Lin; Wan Min; Chi Cailou; Ji Xiusheng

    2007-01-01

    The age forming technology, characterized by huge spring-backs, has been developed to manufacture large integral wing-skin panel parts, which necessitates devising a method of predicting spring-backs. A 7B04-T7451 aluminum alloy creep test in tension is accomplished at 155 ℃, and the creep curves are obtained. The material constants of the mechanism-based creep constitutive equations are determined through experiments. The age forming process and the spring-backs of 7B04 aluminum alloy plates are analyzed using the commercial finite element software ABAQUS. The effects of plate thickness and formingtime on spring-backs are researched. The spring-backs decrease with the increase of plate thickness and forming time. The test results verify the reliability of the finite element method (FEM) analysis.

  15. Hierarchical Bayesian analysis to incorporate age uncertainty in growth curve analysis and estimates of age from length: Florida manatee (Trichechus manatus) carcasses

    Science.gov (United States)

    Schwarz, L.K.; Runge, M.C.

    2009-01-01

    Age estimation of individuals is often an integral part of species management research, and a number of ageestimation techniques are commonly employed. Often, the error in these techniques is not quantified or accounted for in other analyses, particularly in growth curve models used to describe physiological responses to environment and human impacts. Also, noninvasive, quick, and inexpensive methods to estimate age are needed. This research aims to provide two Bayesian methods to (i) incorporate age uncertainty into an age-length Schnute growth model and (ii) produce a method from the growth model to estimate age from length. The methods are then employed for Florida manatee (Trichechus manatus) carcasses. After quantifying the uncertainty in the aging technique (counts of ear bone growth layers), we fit age-length data to the Schnute growth model separately by sex and season. Independent prior information about population age structure and the results of the Schnute model are then combined to estimate age from length. Results describing the age-length relationship agree with our understanding of manatee biology. The new methods allow us to estimate age, with quantified uncertainty, for 98% of collected carcasses: 36% from ear bones, 62% from length.

  16. Testing for Questionable Research Practices in a Meta-Analysis: An Example from Experimental Parapsychology

    Science.gov (United States)

    Bierman, Dick J.; Spottiswoode, James P.; Bijl, Aron

    2016-01-01

    We describe a method of quantifying the effect of Questionable Research Practices (QRPs) on the results of meta-analyses. As an example we simulated a meta-analysis of a controversial telepathy protocol to assess the extent to which these experimental results could be explained by QRPs. Our simulations used the same numbers of studies and trials as the original meta-analysis and the frequencies with which various QRPs were applied in the simulated experiments were based on surveys of experimental psychologists. Results of both the meta-analysis and simulations were characterized by 4 metrics, two describing the trial and mean experiment hit rates (HR) of around 31%, where 25% is expected by chance, one the correlation between sample-size and hit-rate, and one the complete P-value distribution of the database. A genetic algorithm optimized the parameters describing the QRPs, and the fitness of the simulated meta-analysis was defined as the sum of the squares of Z-scores for the 4 metrics. Assuming no anomalous effect a good fit to the empirical meta-analysis was found only by using QRPs with unrealistic parameter-values. Restricting the parameter space to ranges observed in studies of QRP occurrence, under the untested assumption that parapsychologists use comparable QRPs, the fit to the published Ganzfeld meta-analysis with no anomalous effect was poor. We allowed for a real anomalous effect, be it unidentified QRPs or a paranormal effect, where the HR ranged from 25% (chance) to 31%. With an anomalous HR of 27% the fitness became F = 1.8 (p = 0.47 where F = 0 is a perfect fit). We conclude that the very significant probability cited by the Ganzfeld meta-analysis is likely inflated by QRPs, though results are still significant (p = 0.003) with QRPs. Our study demonstrates that quantitative simulations of QRPs can assess their impact. Since meta-analyses in general might be polluted by QRPs, this method has wide applicability outside the domain of experimental

  17. Testing for Questionable Research Practices in a Meta-Analysis: An Example from Experimental Parapsychology.

    Directory of Open Access Journals (Sweden)

    Dick J Bierman

    Full Text Available We describe a method of quantifying the effect of Questionable Research Practices (QRPs on the results of meta-analyses. As an example we simulated a meta-analysis of a controversial telepathy protocol to assess the extent to which these experimental results could be explained by QRPs. Our simulations used the same numbers of studies and trials as the original meta-analysis and the frequencies with which various QRPs were applied in the simulated experiments were based on surveys of experimental psychologists. Results of both the meta-analysis and simulations were characterized by 4 metrics, two describing the trial and mean experiment hit rates (HR of around 31%, where 25% is expected by chance, one the correlation between sample-size and hit-rate, and one the complete P-value distribution of the database. A genetic algorithm optimized the parameters describing the QRPs, and the fitness of the simulated meta-analysis was defined as the sum of the squares of Z-scores for the 4 metrics. Assuming no anomalous effect a good fit to the empirical meta-analysis was found only by using QRPs with unrealistic parameter-values. Restricting the parameter space to ranges observed in studies of QRP occurrence, under the untested assumption that parapsychologists use comparable QRPs, the fit to the published Ganzfeld meta-analysis with no anomalous effect was poor. We allowed for a real anomalous effect, be it unidentified QRPs or a paranormal effect, where the HR ranged from 25% (chance to 31%. With an anomalous HR of 27% the fitness became F = 1.8 (p = 0.47 where F = 0 is a perfect fit. We conclude that the very significant probability cited by the Ganzfeld meta-analysis is likely inflated by QRPs, though results are still significant (p = 0.003 with QRPs. Our study demonstrates that quantitative simulations of QRPs can assess their impact. Since meta-analyses in general might be polluted by QRPs, this method has wide applicability outside the domain of

  18. Experimental functional analysis of severe skin-picking behavior in Prader-Willi syndrome.

    Science.gov (United States)

    Hall, Scott S; Hustyi, Kristin M; Chui, Clara; Hammond, Jennifer L

    2014-10-01

    Skin picking is an extremely distressing and treatment resistant behavior commonly shown by individuals with Prader-Willi syndrome (PWS). However, with the exception of a limited number of published single-case and survey studies, little is known about the environmental determinants of skin picking in this population. In this study, functional analyses were conducted with thirteen individuals with PWS, aged 6-23 years, who engaged in severe skin-picking behavior. In addition to the conditions typically employed in a functional analysis (i.e., alone, attention, play, demand), we included an ignore condition to examine potential effects of stimulus control by the presence of an adult. Twelve participants engaged in skin picking during the functional analysis, with the highest levels occurring in the alone and ignore conditions for eight participants, suggesting that skin picking in these participants was maintained by automatic reinforcement. For the remaining four participants, an undifferentiated pattern of low-rate skin picking was observed across conditions. These data confirm previous studies indicating that skin picking in PWS may be maintained most often by automatically produced sensory consequences. There were no associations between demographic characteristics of the participants (e.g., sex, age, IQ or BMI) and levels of skin picking observed in the functional analysis. Additional investigations are needed to identify the nature of the sensory consequences produced during episodes of skin picking in PWS. Behavioral interventions designed to extinguish or compete with the potential sensory consequences arising from skin picking in PWS are also warranted.

  19. Ageing of passive films on stainless steels in sulfate solutions - XPS analysis

    Energy Technology Data Exchange (ETDEWEB)

    Rossi, A. [Cagliari Univ. (Italy). Dipartimento di Chimica e Technologie Inorganiche e Metallorganiche; Elsener, B. [ETH Hoenggerberg, Zuerich (Switzerland). Inst. of Mater. Chem. and Corrosion

    1995-11-01

    The passivation of stainless steels 1.4301 (18% Cr and 8% Ni) and 1.4529 (20% Cr, 25% Ni and 6% Mo) was studied in neutral 1 M Na{sub 2}SO{sub 4} solutions as a function of polarization time (ageing) at two passivation potential in the passive range by electrochemistry and XPS analysis. The passive current density decreases with time according to a power law indicating higher stability of the passive film after ageing. XPS analyses show that the integral Cr{sup 3+} content in the passive films of the two stainless steels is similar, a slight increase in total film thickness and constant overall composition of the passive film with passivation time is found. ARXPS measurements indicate a bilayer structure and pronounced changes within the passive layer during ageing: Fe{sup 2+} becomes gradually eliminated at longer passivation times. A different ageing behaviour of the 1.4301 (without Mo) and 1.4529 SS (with 6% Mo) is found: the conventional 1.4301 steel shows a more pronounced bilayer structure after 24 h of passivation, but a lower content of hydroxide in the outer layer. On the contrary the passive film of the 1.4529 SS becomes progressively more hydrated during ageing, the amount of Cr(hy) and of OH{sup -} increases with time. The higher pitting resistance of the 1.4529 SS might be explained by the formation of more hydrated (thus more amorphous and flexible) Cr(III)hydroxide passive film, the presence of Mo{sup 6+} and the lower Fe{sup 3+} content in the passive film (reducing pit initiation) together with the marked nickel enrichment at the interface (favouring pit repassivation). (orig.)

  20. Single cell analysis of yeast replicative aging using a new generation of microfluidic device.

    Directory of Open Access Journals (Sweden)

    Yi Zhang

    Full Text Available A major limitation to yeast aging study has been the inability to track mother cells and observe molecular markers during the aging process. The traditional lifespan assay relies on manual micro-manipulation to remove daughter cells from the mother, which is laborious, time consuming, and does not allow long term tracking with high resolution microscopy. Recently, we have developed a microfluidic system capable of retaining mother cells in the microfluidic chambers while removing daughter cells automatically, making it possible to observe fluorescent reporters in single cells throughout their lifespan. Here we report the development of a new generation of microfluidic device that overcomes several limitations of the previous system, making it easier to fabricate and operate, and allowing functions not possible with the previous design. The basic unit of the device consists of microfluidic channels with pensile columns that can physically trap the mother cells while allowing the removal of daughter cells automatically by the flow of the fresh media. The whole microfluidic device contains multiple independent units operating in parallel, allowing simultaneous analysis of multiple strains. Using this system, we have reproduced the lifespan curves for the known long and short-lived mutants, demonstrating the power of the device for automated lifespan measurement. Following fluorescent reporters in single mother cells throughout their lifespan, we discovered a surprising change of expression of the translation elongation factor TEF2 during aging, suggesting altered translational control in aged mother cells. Utilizing the capability of the new device to trap mother-daughter pairs, we analyzed mother-daughter inheritance and found age dependent asymmetric partitioning of a general stress response reporter between mother and daughter cells.

  1. Chemical analysis of interstitial water in rivers of Centro Experimental Aramar area

    Energy Technology Data Exchange (ETDEWEB)

    Matoso, Erika; Goncalves, Julia Rosa, E-mail: ematoso@hotmail.com [Centro Tecnologico da Marinha (CE/CTM-SP), Ipero, SP (Brazil). Centro Experimental Aramar; Cadore, Solange [Universidade Estadual de Campinas (UNICAMP), Campinas, SP (Brazil). Instituto de Quimica. Departamento de Quimica Analitica

    2013-07-01

    This work presents the results from analysis of samples of interstitial waters for the following chemical parameters: F{sup -}, Cl{sup -}, NO{sub 2}{sup -}, Br{sup -}, NO{sub 3}{sup -}, PO{sub 4}{sup 3-}, SO{sub 4}{sup 2-} by Ionic Chromatography, Na, K by Flame Photometry, Al, Cd, Pb, Cu, Cr, Fe, Mn, Ni, Zn by ICP OES, pH and the biological parameter: toxicity by natural bioluminescent bacterium (Vibrio fischeri) bioassay. The samples were obtained from sediments collected in 6 different sampling locations, in a ratio of 10-km-long from Centro Experimental Aramar (CEA). The rivers were the samples came from were: Ipanema River, Sorocaba River and Ribeirao do Ferro River. The interstitial water was extracted by centrifugation (3000 rpm, 20 min, 4 deg C). Analysis for metal concentrations were carried out after acid digestion and others tests proceeded in the sample after filtration without further treatment. These data will contribute to evaluate the distribution of contaminants and nutrients in these collecting points and this toxicity status. The release of soluble substances from sediments to interstitial water provides one way for bioaccumulation of these compounds and may affect the survival or development of aquatic organisms. The analysis in interstitial water has never been evaluated at this sampling points and the importance of this study is collecting data providing a better knowledge of the hydrological conditions in which Centro Experimental Aramar is located. (author)

  2. A generalized rough set-based information filling technique for failure analysis of thruster experimental data

    Institute of Scientific and Technical Information of China (English)

    Han Shan; Zhu Qiang; Li Jianxun; Chen Lin

    2013-01-01

    Interval-valued data and incomplete data are two key problems for failure analysis of thruster experimental data and have been basically solved by the proposed methods in this paper. Firstly, information data acquired from the simulation and evaluation system formed as interval-valued information system (IIS) is classified by the interval similarity relation. Then, as an improve-ment of the classical rough set, a new kind of generalized information entropy called‘‘H0-informa-tion entropy’’ is suggested for the measurement of uncertainty and the classification ability of IIS. There is an innovative information filling technique using the properties of H0-information entropy to replace missing data by some smaller estimation intervals. Finally, an improved method of failure analysis synthesized by the above achievements is presented to classify the thruster experimental data, complete the information, and extract the failure rules. The feasibility and advantage of this method is testified by an actual application of failure analysis, whose performance is evaluated by the quantification of E-condition entropy.

  3. Topological analysis of electron density and the electrostatic properties of isoniazid: an experimental and theoretical study.

    Science.gov (United States)

    Rajalakshmi, Gnanasekaran; Hathwar, Venkatesha R; Kumaradhas, Poomani

    2014-04-01

    Isoniazid (isonicotinohydrazide) is an important first-line antitubercular drug that targets the InhA enzyme which synthesizes the critical component of the mycobacterial cell wall. An experimental charge-density analysis of isoniazid has been performed to understand its structural and electronic properties in the solid state. A high-resolution single-crystal X-ray intensity data has been collected at 90 K. An aspherical multipole refinement was carried out to explore the topological and electrostatic properties of the isoniazid molecule. The experimental results were compared with the theoretical charge-density calculations performed using CRYSTAL09 with the B3LYP/6-31G** method. A topological analysis of the electron density reveals that the Laplacian of electron density of the N-N bond is significantly less negative, which indicates that the charges at the b.c.p. (bond-critical point) of the bond are least accumulated, and so the bond is considered to be weak. As expected, a strong negative electrostatic potential region is present in the vicinity of the O1, N1 and N3 atoms, which are the reactive locations of the molecule. The C-H···N, C-H···O and N-H···N types of intermolecular hydrogen-bonding interactions stabilize the crystal structure. The topological analysis of the electron density on hydrogen bonding shows the strength of intermolecular interactions.

  4. An experimental-numerical method for comparative analysis of joint prosthesis; Un metodo numerico-experimental para el analisis comparativo de protesis articulares

    Energy Technology Data Exchange (ETDEWEB)

    Claramunt, R.; Rincon, E.; Zubizarreta, V.; Ros, A.

    2001-07-01

    The difficulty that exists in the analysis of mechanical stresses in bones is high due to its complex mechanical and morphological characteristics. This complexity makes generalists modelling and conclusions derived from prototype tests very questionable. In this article a relatively simple comparative analysis systematic method that allow us to establish some behaviour differences in different kind of prosthesis is presented. The method, applicable in principle to any joint problem, is based on analysing perturbations produced in natural stress states of a bone after insertion of a joint prosthesis and combines numerical analysis using a 3-D finite element model and experimental studies based on photoelastic coating and electric extensometry. The experimental method is applied to compare two total hip prosthesis cement-free femoral stems of different philosophy. One anatomic of new generation, being of oblique setting over cancellous bone and the other madreporique of trochantero-diaphyseal support over cortical bone. (Author) 4 refs.

  5. Experimental evidence for segregation of interstitial impurities to defects in a near α titanium alloy during dynamic strain aging using energy filtered transmission electron microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Prasad, Kartik, E-mail: kartik@dmrl.drdo.in [Defence Metallurgical Research Laboratory, Kanchanbagh, Hyderabad 500058 (India); School of Engineering Science and Technology, University of Hyderabad, Hyderabad (India); Amrithapandian, S.; Panigrahi, B.K. [Materials Science Group, Indira Gandhi for Centre of Atomic Research, Kalpakkam 603102 (India); Kumar, Vikas [Defence Metallurgical Research Laboratory, Kanchanbagh, Hyderabad 500058 (India); Bhanu Sankara Rao, K. [Mahatma Gandhi Institute of Technology, Gandipet, Hyderabad 500075 (India); Sundararaman, M. [Department of Metallurgical and Materials Engineering, Indian Institute of Technology Madras, Chennai 600036 (India)

    2015-06-25

    Dynamic strain aging was observed in the temperature range between 300 °C and 500 °C in a near α titanium alloy 834 without Silicon (10.38%Al–0.16%Sn–1.86%Zr–0.37%Nb–0.25%Mo–0.27%C–0.30%O–0.006%N, all in at%) tested in the temperature range from room temperature to 500 °C. Electron microscopic investigation of tensile tested samples in an energy filtered transmission electron microscopy provided direct experimental evidence for segregation of interstitial elements like carbon (C) and nitrogen (N) to lath boundaries and dislocation pile ups. On the basis of these results and the comparison of lattice strain generated by different interstitials in α-Ti, it was concluded that segregation of carbon and nitrogen and not oxygen to defects is responsible for DSA in this alloy.

  6. Source and age of carbon in peatland surface waters: new insights from 14C analysis

    Science.gov (United States)

    Billett, Michael; Garnett, Mark; Dinsmore, Kerry; Leith, Fraser

    2013-04-01

    Peatlands are a significant source of carbon to the aquatic environment which is increasingly being recognised as an important flux pathway (both lateral and vertical) in total landscape carbon budgets. Determining the source and age of the carbon (in its various forms) is a key step to understanding the stability of peatland systems as well as the connectivity between the soil carbon pool and the freshwater environment. Novel analytical and sampling methods using molecular sieves have been developed for (1) within-stream, in situ sampling of CO2 in the field and (2) for the removal/separation of CO2 in the laboratory prior to 14C analysis of CH4. Here we present dual isotope (δ13C and 14C) data from freshwater systems in UK and Finnish peatlands to show that significant differences exist in the source and age of CO2, DOC (dissolved organic carbon) and POC (particulate organic carbon). Individual peatlands clearly differ in terms of their isotopic freshwater signature, suggesting that carbon cycling may be "tighter" in some systems compared to others. We have also measured the isotopic signature of different C species in peatland pipes, which appear to be able to tap carbon from different peat depths. This suggests that carbon cycling and transport within "piped-peatlands" may be more complex than previously thought. Some of our most recent work has focussed on the development of a method to measure the 14C component of CH4 in freshwaters. Initial results suggest that CH4 in peatland streams is significantly older than CO2 and derived from a much deeper source. We have also shown that the age (but not the source) of dissolved CO2 changes over the hydrological year in response to seasonal changes in discharge and temperature. Radiocarbon measurements in the peat-riparian-stream system suggest that a significant degree of connectivity exists in terms of C transport and cycling, although the degree of connectivity differs for individual C species. In summary, 14C

  7. Analysis of the shoulder joint mobility in overhead sports before and after experimental treatment

    Directory of Open Access Journals (Sweden)

    Soldatović Srđan

    2011-01-01

    Full Text Available Introduction. ”Overhead” sports, characterized by predominant movements of the hands above the head, are associated with very dynamic, often acyclic movements and require strong muscles of humeroscapular regions with high mobility of the shoulder joint as well as flexibility and ability to relax these muscles. This study was aimed at analyzing the shoulder joint mobility before and after conducting kinesiology treatment for a period of 6 months. The research included two complex exercises. Material and methods. The study included 100 ”overhead” sports male athletes, who were randomly divided into the experimental and control group, aged 14 to 18 years. The range of motion was measured in degrees by goniometer. We calculated the central and depression parameter. Results. There was a statistically significant difference in flexion, extension, abduction, adduction, external and internal rotation at the final measure in favor of the experimental group at the level of significance p<0.001, and some positive effects of the applied exercises were observed. Discussion. Kinesitherapy had positive effects on the elasticity of the connective tissue capsule, ligaments and tendons. Changes in the shoulder area of the ”overhead” sports athletes can be reduced to the same extent and at the same time by stretching and strength exercises. Conclusion. The authors of this paper have given their modest contribution by suggesting a more appropriate planning of training and performance of players at training and matches. This paper tries to emphasize the importance of proper incorporation of the corrective exercises in training.

  8. The use of experimental data in an MTR-type nuclear reactor safety analysis

    Science.gov (United States)

    Day, Simon E.

    Reactivity initiated accidents (RIAs) are a category of events required for research reactor safety analysis. A subset of this is unprotected RIAs in which mechanical systems or human intervention are not credited in the response of the system. Light-water cooled and moderated MTR-type ( i.e., aluminum-clad uranium plate fuel) reactors are self-limiting up to some reactivity insertion limit beyond which fuel damage occurs. This characteristic was studied in the Borax and Spert reactor tests of the 1950s and 1960s in the USA. This thesis considers the use of this experimental data in generic MTR-type reactor safety analysis. The approach presented herein is based on fundamental phenomenological understanding and uses correlations in the reactor test data with suitable account taken for differences in important system parameters. Specifically, a semi-empirical approach is used to quantify the relationship between the power, energy and temperature rise response of the system as well as parametric dependencies on void coefficient and the degree of subcooling. Secondary effects including the dependence on coolant flow are also examined. A rigorous curve fitting approach and error assessment is used to quantify the trends in the experimental data. In addition to the initial power burst stage of an unprotected transient, the longer term stability of the system is considered with a stylized treatment of characteristic power/temperature oscillations (chugging). A bridge from the HEU-based experimental data to the LEU fuel cycle is assessed and outlined based on existing simulation results presented in the literature. A cell-model based parametric study is included. The results are used to construct a practical safety analysis methodology for determining reactivity insertion safety limits for a light-water moderated and cooled MTR-type core.

  9. Electrochemical characterization and post-mortem analysis of aged LiMn2O4-NMC/graphite lithium ion batteries part II: Calendar aging

    Science.gov (United States)

    Stiaszny, Barbara; Ziegler, Jörg C.; Krauß, Elke E.; Zhang, Mengjia; Schmidt, Jan P.; Ivers-Tiffée, Ellen

    2014-07-01

    A detailed post-mortem analysis was carried out for commercial lithium ion batteries stored at 4.2 V and 4.0 V at 60 °C. Complementary electrochemical and physical-analytical investigations revealed that the most significant aging processes for the cells aged at 4.2 V were loss of cycleable lithium, decomposition of the electrolyte and loss of active cathode material (LiMn2O4/Li(Ni0.5Mn0.3Co0.2)O2). The cells aged at 4.0 V also exhibited loss of cycleable lithium, but at a smaller extent. In fact, the aged anodes did not show significant changes compared to the new anode. Electrochemical impedance measurements including symmetric laboratory test cells gained from new and aged cells revealed valuable information about changing charge-transfer processes. The 4.2 V-cathode and both aged anodes surprisingly exhibited a decreased charge-transfer resistance, while the 4.0 V-cathode's charge-transfer resistance increased.

  10. Ames S-32 O-16 O-18 Line List for High-Resolution Experimental IR Analysis

    Science.gov (United States)

    Huang, Xinchuan; Schwenke, David W.; Lee, Timothy J.

    2016-01-01

    By comparing to the most recent experimental data and spectra of the SO2 628 ?1/?3 bands (see Ulenikov et al., JQSRT 168 (2016) 29-39), this study illustrates the reliability and accuracy of the Ames-296K SO2 line list, which is accurate enough to facilitate such high-resolution spectroscopic analysis. The SO2 628 IR line list is computed on a recently improved potential energy surface (PES) refinement, denoted Ames-Pre2, and the published purely ab initio CCSD(T)/aug-cc-pVQZ dipole moment surface. Progress has been made in both energy level convergence and rovibrational quantum number assignments agreeing with laboratory analysis models. The accuracy of the computed 628 energy levels and line list is similar to what has been achieved and reported for SO2 626 and 646, i.e. 0.01-0.03 cm(exp -1) for bands up to 5500 cm(exp -1). During the comparison, we found some discrepancies in addition to overall good agreements. The three-IR-list based feature-by-feature analysis in a 0.25 cm(exp -1) spectral window clearly demonstrates the power of the current Ames line lists with new assignments, correction of some errors, and intensity contributions from varied sources including other isotopologues. We are inclined to attribute part of detected discrepancies to an incomplete experimental analysis and missing intensity in the model. With complete line position, intensity, and rovibrational quantum numbers determined at 296 K, spectroscopic analysis is significantly facilitated especially for a spectral range exhibiting such an unusually high density of lines. The computed 628 rovibrational levels and line list are accurate enough to provide alternatives for the missing bands or suspicious assignments, as well as helpful to identify these isotopologues in various celestial environments. The next step will be to revisit the SO2 828 and 646 spectral analyses.

  11. Ames 32S16O18O line list for high-resolution experimental IR analysis

    Science.gov (United States)

    Huang, Xinchuan; Schwenke, David W.; Lee, Timothy J.

    2016-12-01

    By comparing to the most recent experimental data and spectra of the SO2 628 ν1/ν3 bands (see Ulenikov et al., JQSRT 168 (2016) 29-39), this study illustrates the reliability and accuracy of the Ames-296K SO2 line list, which is accurate enough to facilitate such high-resolution spectroscopic analysis. The SO2 628 IR line list is computed on a recently improved potential energy surface (PES) refinement, denoted Ames-Pre2, and the published purely ab initio CCSD(T)/aug-cc-pV(Q+d)Z dipole moment surface. Progress has been made in both energy level convergence and rovibrational quantum number assignments agreeing with laboratory analysis models. The accuracy of the computed 628 energy levels and line list is similar to what has been achieved and reported for SO2 626 and 646, i.e. 0.01-0.03 cm-1 for bands up to 5500 cm-1. During the comparison, we found some discrepancies in addition to overall good agreements. The three-IR-list based feature-by-feature analysis in a 0.25 cm-1 spectral window clearly demonstrates the power of the current Ames line lists with new assignments, correction of some errors, and intensity contributions from varied sources including other isotopologues. We are inclined to attribute part of detected discrepancies to an incomplete experimental analysis and missing intensity in the model. With complete line position, intensity, and rovibrational quantum numbers determined at 296 K, spectroscopic analysis is significantly facilitated especially for a spectral range exhibiting such an unusually high density of lines. The computed 628 rovibrational levels and line list are accurate enough to provide alternatives for the missing bands or suspicious assignments, as well as helpful to identify these isotopologues in various celestial environments. The next step will be to revisit the SO2 828 and 646 spectral analyses.

  12. Design, Analysis, Prototyping, and Experimental Evaluation of an Efficient Double Coil Magnetorheological Valve

    Directory of Open Access Journals (Sweden)

    Guoliang Hu

    2014-05-01

    Full Text Available A double coil magnetorheological (MR valve with an outer annular resistance gap was designed and prototyped. The finite element modeling and analysis of double coil MR valve were carried out using ANSYS/Emag software, and the optimal magnetic field distribution and magnetic flux density of the double coil MR valve were achieved. The mechanism of the pressure drop was studied by building a mathematical model of pressure drop in the double coil MR valve. The proposed double coil MR valve was prototyped and its performance was experimentally evaluated. The new MR valve design has improved the efficiency of double coil MR valve significantly.

  13. Theory analysis and experimental research on on-line contamination detecting technology in hydraulic oil

    Institute of Scientific and Technical Information of China (English)

    YAO Cheng-yu; ZHAO Jing-yi; ZHANG Qi-sheng

    2006-01-01

    A system of on-line contamination detecting in hydraulic oil based on silting principle is accomplished, where, metal filter membrane as detector, solenoid as active force to propel piston to blotter and gain differential pressure, step motor drives the membrane to filtrate and counter-flush, LabVIEW as detecting software platform, oil's contamination detecting indirectly by gauging differential pressure. Based on theory analysis, accomplished is relation between contamination level and differential pressure, realizing polynomial curve fitting, and calibration experiment. Field experiment is simulated in the condition of experimental laboratory, has credible precision and real-time performance, which can popularize to the field of production.

  14. Used frying oil biodiesel production: experimental factorial design and multivariate analysis

    Directory of Open Access Journals (Sweden)

    Rosana de Cassia de Souza Schneider

    2009-01-01

    Full Text Available Biodiesel é derivado de fontes renováveis ereduz significativamente as emissões atmosféricas. Pode serobtido de diversos processos, como a alcoolise. Nestetrabalho, o biodiesel foi produzido através da alcoolise doóleo de fritura usado de indústrias de alimentação. Umplanejamento experimental foi utilizado e os produtos dereação foram analisados por cromatografia gasosa (CGespectroscopia na região do infravermelho com acessório dereflexão total atenuada horizontal (IV-HATR e análiseexploratória por análise de componentes principais (PCA eanálise hierárquica de grupos (HCA. De acordo com ascondições analisadas obteve-se alta conversão em ésteresmetílicos. Por IV-HATR, a conversão máxima foi observadaem condições experimentais de temperatura ( 50 e 60°C,concentração de catalisador (0,6 e 1,2% e a 1:8 de relaçãomolar entre óleo e metanol. Também foi possíveldiscriminar por análise quimiométrica, 4 grupos noplanejamento experimental e determinar as melhorescondições para a produção de biodiesel de óleo de friturausado.Abstract Biodiesel is derived from renewable sources and it significantly reduces atmospheric emissions. It can be obtained byseveral processes, such as alcoholysis. In this work, biodiesel was produced through alcoholysis of used frying oil from a cateringbusiness. An experimental factorial design was used and the reaction products were analyzed through gas chromatography (GC,horizontal attenuated total reflection Fourier transform infrared (HATR/FT-IR spectroscopy and exploratory analysis withprincipal component analysis (PCA and hierarchical cluster analysis (HCA. Under the conditions analyzed, a high degree ofconversion to methyl ester was found. As shown by HATR/FT-IR, the maximum conversion was obtained when the experimentalconditions had the temperature ( 50 e 60°C, largest catalyst concentration (0,6 e 1,2% and a 1:8 molar proportion of oil tomethanol. It was possible to discriminate

  15. Experimental analysis of the environmental contamination of electrical equipment; Analisis experimental de la contaminacion ambiental en equipos electricos

    Energy Technology Data Exchange (ETDEWEB)

    Campillo Ruiz, Maria Teresa; Ponce Velez, Marco Antonio [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1996-12-31

    This paper is a summary of the main causes that originate the contamination problems in insulating materials. This as the result of different studies performed in experimental testing stations, as well as in transmission, distribution and laboratory power lines by the Departamento de Materiales of the Instituto de Investigaciones Electricas (IIE). [Espanol] En el presente trabajo se muestra un resumen de los principales factores que originan los problemas de contaminacion en aislamientos. Esto, como resultado de diversos estudios realizados tanto en estaciones de prueba experimentales como en lineas de transmision, distribucion y laboratorio por el Departamento de Materiales del Instituto de Investigaciones Electricas (IIE).

  16. The application of age distribution theory in the analysis of cytofluorimetric DNA histogram data.

    Science.gov (United States)

    Watson, J V

    1977-03-01

    Age distribution theory has been employed in a model to analyse a variety of histograms of the DNA content of single cells in samples from experimental tumours growing in tissue culture. The method has produced satisfactory correspondence with the experimental data in which there was a wide variation in the proportions of cells in the intermitotic phases, and generally good agreement between the 3H-thymidine labelling index and the computed proportion in S phase. The model has the capacity to analyse data from populations which contain a proportion of non-cycling cells. However, it is concluded that reliable results for the growth fraction and also for the relative durations of the intermitotic phase times cannot be obtained for the data reported here from the DNA histograms alone. To obtain reliable estimates of the growth fraction the relative durations of the phase time must be known, and conversely, reliable estimates of the relative phase durations can only be obtained if the growth fraction is known.

  17. Development of a short version of the Aging Males' Symptoms scale: Mokken scaling analysis and Rasch analysis.

    Science.gov (United States)

    Lee, Chin-Pang; Chen, Yu; Jiang, Kun-Hao; Chu, Chun-Lin; Chiu, Yu-Wen; Chen, Jiun-Liang; Chen, Ching-Yen

    2016-06-01

    The aim of this study was to develop a psychometrically sound short version of the 17-item Aging Males' Symptoms (AMS) scale using Mokken scale analysis (MSA) and Rasch analysis. We recruited a convenient sample of 1787 men (age: mean (SD) = 43.8 (11.5) years) who visited a men's health polyclinic in Taiwan and completed the AMS scale. The scale was first assessed using MSA. The remaining items were assessed using Rasch analysis. We used a stepwise approach to remove items with χ(2) item statistics and mean square values while monitoring unidimensionality. The item reduction process resulted in a 6-item version of the AMS scale (AMS-6). The AMS-6 scale included a 5-item psychosomatic subscale (original items 1, 4, 5, 8, and 9) and a 1-item sexual subscale (original item 16). Analyses confirmed that the 5-item psychosomatic subscale was a Rasch scale. The AMS-6 correlated well with the AMS scales: the 5-item psychosomatic subscale correlated with the AMS scale (r between 0.50 and 0.92); the 1-item sexual subscale correlated with the sexual subscale of the AMS scale (r = 0.81). A 6-item short form of the AMS scale had satisfactory measurement properties. This version may be useful for estimating psychosomatic and sexual symptoms as well as health-related quality of life with a minimal burden on respondents.

  18. Instrumental analysis for differentiation of beers and evaluation of beer ageing

    Science.gov (United States)

    Dreve, Simina; Voica, Cezara; Dragan, Felicia; Georgiu, Monica

    2013-11-01

    A representative selection of 5 different beers commercially available were measured spectrophotometrically in UV-Vis spectral region and by fluorescence spectroscopy, in order to determine qualitative differentiation due to the mainly iso-R-acids (with a five member ring) originating from R-acids present in hops. Minerals and trace elements analysis were also performed by ICP-MS method. The determination of the bitter organic acids in beers and of the content in metallic ions can be used as indicators for differentiation of beers and evaluation of beer ageing.

  19. PIXE analysis in uninvolved skin of atopic patients and in aged skin

    Energy Technology Data Exchange (ETDEWEB)

    Bunse, T.; Steigleder, K. (Universitaets-Hautklinik, Koeln (Germany)); Hoefert, M.; Gonsior, B. (Institut fuer Experimentalphysik, Ruhr-Universitaet, Bochum (Germany))

    1991-01-01

    PIXE analysis was used to determine the elemental distribution in normal-appearing skin of patients suffering from atopic eczema and in the skin of elderly people. With this technique, elements with atomic numbers {>=} 14 can be detected simultaneously in cryosections of skin biopsies down to a concentration of 1 ppm. Compared with a control group, the epidermal concentrations of Zn and CU, which are constituent parts of a variety of enzymes, were increased in uninvolved skin of patients with atopic eczema. In the epidermis of elderly people the level of K was lower and that of Ca was higher than in the epidermis of a younger age group. (au).

  20. Association between SERPING1 rs2511989 polymorphism and age-related macular degeneration: Meta-analysis

    Institute of Scientific and Technical Information of China (English)

    Yi; Dong; Ze-Dong; Li; Xin-Yu; Fang; Xue-Feng; Shi; Song; Chen; Xin; Tang

    2015-01-01

    AIM: To investigate the association between SERPING1rs2511989(G>A) polymorphism and age-related macular degeneration(AMD).METHODS: A number of electronic databases(up to July 15, 2014) were searched independently by two investigators. A Meta-analysis was performed on the association between SERPING1 rs2511989 polymorphism and AMD. Pooled odds ratios(ORs) with 95% confidence intervals(CIs) were estimated.RESULTS: Eight studies with 16 cohorts consisting of9163 cases and 6813 controls were included in this Metaanalysis. There was no significant association between rs2511989 polymorphism and AMD under all genetic models in overall estimates(A vs G: OR= 0.938, 95%CI =0.858-1.025; AA vs GG:OR =0.871, 95% CI =0.719-1.056;AG vs GG: OR =0.944, 95% CI =0.845-1.054; AA +AG vs GG: OR =0.927, 95% CI =0.823-1.044; AA vs AG +GG:OR =0.890, 95% CI =0.780-1.034). Cumulative Meta-analyses also showed a trend of no association between rs2511989 polymorphism and AMD as information accumulated by year. Subgroup analysis and Meta-regression analysis indicated that age-matching status was the main source of heterogeneity. Sensitivity analysis found the results in overall comparisons and subgroup comparisons of white subjects under the allele model were found to have significantly statistical differences after studies deviating from Hardy-Weinberg equilibrium(HWE) were excluded(overall: OR=0.918, 95%CI = 0.844-0.999, P =0.049; whites: OR =0.901, 95% CI =0.817-0.994, P =0.038). However, the results were notsufficiently robust for further sensitivity analysis and statistical differences disappeared on applying Bonferroni correction(with a significance level set at 0.05/25).CONCLUSION: This Meta-analysis indicates that SERPING1 rs2511989 polymorphism and AMD tend to have no association with each other. Age matching status is a big confounding factor, and more studies with subtle designs are warranted in future.

  1. Experimental and theoretical analyses of the age-dependent large-strain behavior of Sylgard 184 (10:1) silicone elastomer.

    Science.gov (United States)

    Hopf, R; Bernardi, L; Menze, J; Zündel, M; Mazza, E; Ehret, A E

    2016-07-01

    The commercial polydimethysiloxane elastomer Sylgard(®) 184 with mixing ratio 10:1 is in wide use for biomedical research or fundamental studies of mechanobiology. In this paper, a comprehensive study of the large strain mechanical behavior of this material under multiaxial monotonic and cyclic loads, and its change during the first 26 days after preparation is reported. The equibiaxial stress response studied in inflation experiments reveals a much stiffer and more nonlinear response compared to the uniaxial and pure shear characteristics. The polymer revealed remarkably elastic behavior, in particular, very little dependence on strain rates between 0.3%/s and 11%/s, and on the strain history in cyclic experiments. On the other hand, both the small-strain and large strain nonlinear mechanical characteristics of the elastomer are changing with sample age and the results suggest that this process has not ceased after 26 days. A recent re-interpretation of the well-known Ogden model for incompressible rubber-like materials was applied to rationalize the results and accurate agreement was obtained with the experimental data over all testing configurations and testing times. The change of a single parameter in this model is shown to govern the evolution of the nonlinear material characteristics with sample age, attributed to a continuation of the cross-linking process. Based on a kinetic relation to account for this process over time, the model provided successful predictions of the material behavior even after more than one year.

  2. Dental computed tomographic imaging as age estimation: morphological analysis of the third molar of a group of Turkish population.

    Science.gov (United States)

    Cantekin, Kenan; Sekerci, Ahmet Ercan; Buyuk, Suleyman Kutalmis

    2013-12-01

    Computed tomography (CT) is capable of providing accurate and measurable 3-dimensional images of the third molar. The aims of this study were to analyze the development of the mandibular third molar and its relation to chronological age and to create new reference data for a group of Turkish participants aged 9 to 25 years on the basis of cone-beam CT images. All data were obtained from the patients' records including medical, social, and dental anamnesis and cone-beam CT images of 752 patients. Linear regression analysis was performed to obtain regression formulas for dental age calculation with chronological age and to determine the coefficient of determination (r) for each sex. Statistical analysis showed a strong correlation between age and third-molar development for the males (r2 = 0.80) and the females (r2 = 0.78). Computed tomographic images are clinically useful for accurate and reliable estimation of dental ages of children and youth.

  3. Mechanism Analysis and Experimental Validation of Employing Superconducting Magnetic Energy Storage to Enhance Power System Stability

    Directory of Open Access Journals (Sweden)

    Xiaohan Shi

    2015-01-01

    Full Text Available This paper investigates the mechanism analysis and the experimental validation of employing superconducting magnetic energy storage (SMES to enhance power system stability. The models of the SMES device and the single-machine infinite-bus (SMIB system with SMES are deduced. Based on the model of the SMIB system with SMES, the action mechanism of SMES on a generator is analyzed. The analysis takes the impact of SMES location and the system operating point into consideration, as well. Based on the mechanism analysis, the P-controller and Q-controller are designed utilizing the phase compensation method to improve the damping of the SMIB system. The influence of factors, such as SMES location, transmission system reactance, the dynamic characteristics of SMES and the system operating point, on the damping improvement of SMES, is investigated through root locus analysis. The simulation results of the SMIB test system verify the analysis conclusions and controller design method. The laboratory results of the 150-kJ/100-kW high-temperature SMES (HT-SMES device validate that the SMES device can effectively enhance the damping, as well as the transient stability of the power system.

  4. Experimental and NMR theoretical methodology applied to geometric analysis of the bioactive clerodane trans-dehydrocrotonin

    Energy Technology Data Exchange (ETDEWEB)

    Soares, Breno Almeida; Firme, Caio Lima, E-mail: firme.caio@gmail.com, E-mail: caiofirme@quimica.ufrn.br [Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil). Instituto de Quimica; Maciel, Maria Aparecida Medeiros [Universidade Potiguar, Natal, RN (Brazil). Programa de Pos-graduacao em Biotecnologia; Kaiser, Carlos R. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Instituto de Quimica; Schilling, Eduardo; Bortoluzzi, Adailton J. [Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC (Brazil). Departamento de Quimica

    2014-04-15

    trans-Dehydrocrotonin (t-DCTN) a bioactive 19-nor-diterpenoid clerodane type isolated from Croton cajucara Benth, is one of the most investigated clerodane in the current literature. In this work, a new approach joining X-ray diffraction data, nuclear magnetic resonance (NMR) data and theoretical calculations was applied to the thorough characterization of t-DCTN. For that, the geometry of t-DCTN was reevaluated by X-ray diffraction as well as {sup 1}H and {sup 13}C NMR data, whose geometrical parameters where compared to those obtained from B3LYP/6-311G++(d,p) level of theory. From the evaluation of both calculated and experimental values of {sup 1}H and {sup 13}C NMR chemical shifts and spin-spin coupling constants, it was found very good correlations between theoretical and experimental magnetic properties of t-DCTN. Additionally, the delocalization indexes between hydrogen atoms correlated accurately with theoretical and experimental spin-spin coupling constants. An additional topological analysis from quantum theory of atoms in molecules (QTAIM) showed intramolecular interactions for t-DCTN. (author)

  5. Analysis of experimental evidence that shows adverse effects of salt and its relation to hypertension

    Directory of Open Access Journals (Sweden)

    Ignacio Bravo A.

    2012-02-01

    Full Text Available The study by Taylor et al published in June 2010 in the American Journal of Hypertension questions the effectiveness of reducing salt intake in the diet in the prevention and treatment of high blood pressure and other cardiovascular conditions. The publication of this article has lead to great controversy and medical associations and learned societies responded promptly. The response criticized the results of the meta-analysis and pointed out its methodological shortcomings. In this review we critically appraise the experimental evidence that shows the importance of diet salt intake and its role as a determinant of blood pressure. We briefly describe the paradigm that explains the role of salt intake in contributing in the regulation of blood pressure (Guyton hypothesis and model and we mention the experimental evidence that supports this. We briefly comment on the classical studies that indicate that salt intake (NaCl contributes directly to the development of high blood pressure and target tissues. Finally, we briefly mention the experimental data that is related with the controversy on the role of salt (NaCl or sodium as prohypertensive agents.

  6. A unified phenomenological analysis of the experimental velocity curves in molecular motors.

    Science.gov (United States)

    Ciudad, Aleix; Sancho, J M

    2008-06-14

    We present a unified phenomenological kinetic framework to analyze the experimental data of several motor proteins (either linear or rotatory). This formalism allows us to discriminate the characteristic times of most relevant subprocesses. Explicitly, internal mechanical as well as chemical times are taken into account and joined together in a full-cycle time where effusion, diffusion and chemical rates, viscoelastic friction, and overdamped motion are considered. This approach clarifies the most relevant mechanisms in a particular motor by using the available experimental data of velocity versus external load and substrate concentration. We apply our analysis to three real molecular motors for which enough experimental data are available: the bacterial flagellar motor [Yoshiyuki et al., J. Mol. Biol. 377, 1043 (2003)], conventional kinesin (kinesin-1) [Block et al., Proc. Natl. Acad. Sci. U.S.A. 100, 2351 (2003)], and a RAN polymerase [Abbondanzieril, Nature (London) 438, 460 (2003)]. Moreover, the mechanism of stalling a motor is revised and split into two different concepts (mechanical and chemical stalling) that shed light to the understanding of backstepping in kinesin-1.

  7. Experimental and numerical analysis of Izod impact test of cortical bone tissue

    Science.gov (United States)

    Abdel-Wahab, A. A.; Silberschmidt, V. V.

    2012-05-01

    Bones can only sustain loads until a certain limit, beyond which they fail. Usually, the reasons for bone fracture are traumatic falls, sports injuries, and engagement in transport or industrial accidents. A proper treatment of bones and prevention of their fracture can be supported by in-depth understanding of deformation and fracture behavior of this tissue in such dynamic events. In this paper, a combination of experimental and numerical analysis was carried out in order to comprehend the fracture behavior of cortical bone tissue. Experimental tests were performed to study the transient dynamic behavior of cortical bone tissue under impact bending loading. The variability of absorbed energy for different cortex positions and notch depths was studied using Izod impact tests. Also, Extended Finite-Element Method implemented into the commercial finite-element software Abaqus was used to simulate the crack initiation and growth processes in a cantilever beam of cortical bone exposed to impact loading using the Izod loading scheme. The simulation results show a good agreement with the experimental data.

  8. Simulation modeling and experimental analysis of thermodynamic charge performance in a variable-mass thermodynamic system

    Institute of Scientific and Technical Information of China (English)

    胡继敏; 金家善; 严志腾

    2013-01-01

    The thermodynamic charge performance of a variable-mass thermodynamic system was investigated by the simulation modeling and experimental analysis. Three sets of experiments were conducted for various charge time and charge steam flow under three different control strategies of charge valve. Characteristic performance parameters from the average sub-cooled degree and the charging energy coefficient point of views were also defined to evaluate and predict the charge performance of system combined with the simulation model and experimental data. The results show that the average steam flow reflects the average sub-cooled degree qualitatively, while the charging energy coefficients of 74.6%, 69.9% and 100% relate to the end value of the average sub-cooled degree at 2.1, 2.9 and 0 respectively for the three sets of experiments. The mean and maximum deviations of the results predicted from those by experimental data are smaller than 6.8% and 10.8%, respectively. In conclusion, the decrease of average steam flow can effectively increase the charging energy coefficient in the same charge time condition and therefore improve the thermodynamic charge performance of system. While the increase of the charging energy coefficient by extending the charge time needs the consideration of the operating frequency for steam users.

  9. Authentication of Rembrandt's self-portraits through the use of facial aging analysis.

    Science.gov (United States)

    Friedman, Tal; Lurie, Doron J; Shalom, Avshalom

    2012-10-01

    The Dutch painter Rembrandt van Rijn (1606-1669) left behind the largest collection of self-portraits in the history of art. Although about 40 of his oil paintings could be considered "self-portraits," controversy still exists regarding 14 of them. We undertook to determine the identity of the painter or the subject. Our work was based on the generally accepted premise that these portraits represent a "realistic" rendering of the subject. Self-portraits on which there is consensus regarding the authenticity were chosen as the basis for our measurements. Using a computerized technique we measured the brow ptosis. We also subjectively analyzed Rembrandt's facial aging and the unique asymmetrical elements in his face. We could not add any useful information on 6 of the 14 portraits and suggest that 8 should be considered authentic. Facial aging analysis and the unique surface anatomy allowed us to confirm Rembrandt as the painter in four of six self-portraits. We confirmed Rembrandt as the subject and painter in three more paintings. Of the two paintings in which the subject's identity was controversial, we determined Rembrandt as the subject in one. We were able to date Rembrandt's age in two other works and considered another portrait to be a copy. Our methodology may serve as an additional tool for the authentication of self-portraits.

  10. Survival analysis of timing of first marriage among women of reproductive age in Nigeria: regional differences.

    Science.gov (United States)

    Adebowale, Stephen A; Fagbamigbe, Francis A; Okareh, Titus O; Lawal, Ganiyu O

    2012-12-01

    Early marriage is common among women in developing countries. Age at first marriage (AFM) has health implication on women and their under-five children. In Nigeria, few studies have explored AFM; the current study was designed to fill the gap. Nigeria Demographic and Health Survey, 2008 dataset on married women aged 15-49 (N = 24,986) was used. Chi-square, OLS regression and Cox proportional hazard models were used in the analysis. The mean AFM was 17.8 +/- 4.8 years and significant difference existed between the mean AFM of women in the North (16.0 +/- 3.6) and South (20.4 +/- 5.0) (p marriage (p marriage was more common in all the regions in the North than the South and the hazard was highest in the North West and North East. Women who reside in rural area (H.R = 1.15; C.I = 1.11-1.18) married early than their counterparts in the urban area. Age at first marriage was directly related to levels of education (p marriage more common in the North than the South. Education has influence on AFM; therefore, women should have at least secondary education before marriage in Nigeria.

  11. Photoelastic stress analysis assisted evaluation of fracture toughness in hydrothermally aged epoxies

    Directory of Open Access Journals (Sweden)

    G. Pitarresi

    2014-10-01

    Full Text Available The present work has investigated the fracture toughness of a model DGEBA epoxy system subject to Hidro-Thermal aging. A Photoelastic Stress Analysis technique has been implemented, showing the evolution of stresses arising throughout the water uptake process due to the non-uniform swelling of the material. Gravimetric and Dynamic Mechanical Thermal Analyses have further complemented the characterization, showing the onset of plasticization effects with aging. The correlation of all previous characterizations has allowed to conclude that an increase of KIC fracture toughness is obtained at the fully saturated condition. In particular Photoelasticity has also revealed the onset of relevant swelling induced stresses during the first stages of water absorption, leading to an increase of fracture toughness due to compressive stresses settling near the crack tip. A stress free condition is instead reestablished at the later stages of absorption, suggesting that the increased toughness of the saturated material is an effect of the modifications induced by aging on the polymer structure.

  12. Development of advanced methods for analysis of experimental data in diffusion

    Science.gov (United States)

    Jaques, Alonso V.

    There are numerous experimental configurations and data analysis techniques for the characterization of diffusion phenomena. However, the mathematical methods for estimating diffusivities traditionally do not take into account the effects of experimental errors in the data, and often require smooth, noiseless data sets to perform the necessary analysis steps. The current methods used for data smoothing require strong assumptions which can introduce numerical "artifacts" into the data, affecting confidence in the estimated parameters. The Boltzmann-Matano method is used extensively in the determination of concentration - dependent diffusivities, D(C), in alloys. In the course of analyzing experimental data, numerical integrations and differentiations of the concentration profile are performed. These methods require smoothing of the data prior to analysis. We present here an approach to the Boltzmann-Matano method that is based on a regularization method to estimate a differentiation operation on the data, i.e., estimate the concentration gradient term, which is important in the analysis process for determining the diffusivity. This approach, therefore, has the potential to be less subjective, and in numerical simulations shows an increased accuracy in the estimated diffusion coefficients. We present a regression approach to estimate linear multicomponent diffusion coefficients that eliminates the need pre-treat or pre-condition the concentration profile. This approach fits the data to a functional form of the mathematical expression for the concentration profile, and allows us to determine the diffusivity matrix directly from the fitted parameters. Reformulation of the equation for the analytical solution is done in order to reduce the size of the problem and accelerate the convergence. The objective function for the regression can incorporate point estimations for error in the concentration, improving the statistical confidence in the estimated diffusivity matrix

  13. Experimental study and analysis of a novel multi-media plate heat exchanger

    Institute of Scientific and Technical Information of China (English)

    SONG JiWei; WANG Fei; CHENG Lin

    2012-01-01

    The experimental study and analysis of a novel multi-media plate heat exchanger were performed in this paper.This novel multi-media plate heat exchanger was self-developed during the process of the investigation and design of the alpha magnetic spectrometer (AMS) thermal system.The plate of this kind of novel plate heat exchanger is formed by discontinuous structure wave consisting of convex sphere and concave sphere,its heat transfer performance is better than that of the BRI chevron plate heat exchanger,and its resistance characteristics are superior to those of the nornally used 60-degree plate heat exchanger.Furthermore,the mechanism analysis of heat transfer enhancement shows that the spherical wave structure can reduce the local field synergy angle,so as to improve the field synergy degree of velocity vector and temperature gradient vector.

  14. TecPIV-A MATLAB-based application for PIV-analysis of experimental tectonics

    Science.gov (United States)

    Boutelier, D.

    2016-04-01

    TecPIV is a MATLAB-based, open source application aiming to facilitate and accelerate the Particle Image Velocimetry (PIV) analysis of analogue tectonic models. Since tectonic modelling experiments are usually slow, low sensitivity but high resolution digital cameras can be employed to monitor displacements and calculate strain from PIV analysis. The presented work-flow package provides an integrated environment to import raw files, calibrate, enhance, undistort and rectify the views of the model, calculate the incremental displacements between successive images, the spatial derivatives, and the Eulerian cumulative displacements. The calibration procedure employs a combination of linear and polynomial functions allowing correction of both lens and parallax distortions. The cross-correlation uses a parallelized FFT-method to accelerate the processing of large images. The performance is tested using synthetic images designed to evaluate the precision of the produced velocity field for various settings as well as the ability to capture sharp features characteristic of experimental tectonics.

  15. CFD analysis and experimental investigations towards optimizing the parameters of Ranque-Hilsch vortex tube

    Energy Technology Data Exchange (ETDEWEB)

    Behera, U.; Paul, P.J. [Indian Institute of Science, Bangalore (India). Department of Aerospace Engineering; Kasthurirengan, S.; Karunanithi, R.; Ram, S.N.; Dinesh, K.; Jacob, S. [Indian Institute of Science, Bangalore (India). Centre for Cryogenic Technology

    2005-05-01

    Computational fluid dynamics (CFD) and experimental studies are conducted towards the optimization of the Ranque-Hilsch vortex tubes. Different types of nozzle profiles and number of nozzles are evaluated by CFD analysis. The swirl velocity, axial velocity and radial velocity components as well as the flow patterns including secondary circulation flow have been evaluated. The optimum cold end diameter (d{sub c}) and the length to diameter (L/D) ratios and optimum parameters for obtaining the maximum hot gas temperature and minimum cold gas temperature are obtained through CFD analysis and validated through experiments. The coefficient of performance (COP) of the vortex tube as a heat engine and as a refrigerator has been calculated. (author)

  16. THEORETICAL AND EXPERIMENTAL ANALYSIS OF A CROSS-FLOW HEAT EXCHANGER

    Directory of Open Access Journals (Sweden)

    R. Tuğrul OĞULATA

    1996-03-01

    Full Text Available In this study, cross-flow plate type heat exchanger has been investigated because of its effective use in waste heat recovery systems. For this purpose, a heat regain system has been investigated and manufactured in laboratory conditions. Manufactured heat exchanger has been tested with an applicable experimental set up and temperatures, velocity of the air and the pressure losses occuring in the system have been measured and the efficiency of the system has been determined. The irreversibility of heat exchanger has been taken into consideration while the design of heat exchanger is being performed. So minimum entropy generation number has been analysied with respect to second law of thermodynamics in cross-flow heat exchanger. The minimum entropy generation number depends on parameters called optimum flow path length, dimensionless mass velocity and dimensionless heat transfer area. Variations of entropy generation number with these parameters have been analysied and introduced their graphics with their comments.

  17. A comparative theoretical-experimental analysis of settlements of shallow foundations on granular soil

    Directory of Open Access Journals (Sweden)

    Davidović Nebojša

    2010-01-01

    Full Text Available The paper presents a brief description of experiment within the research project 'Theoretical and experimental analysis of interaction of shallow reinforced concrete foundations and soil for the purpose of improvement of national regulations and implementaation of Eurocode system' where in situ tests of a series of reinforced concrete foundation footing were performed, by loading until failure. As a rule, methods for calculation of shallow foundations settlement on granular soils overestimate the expected settlement, and underestimate soil bearing capacity, which results in a conservative foundation design. In order to test accuracy and reliability of the different settlements prediction methods, a comparative analysis of settlements calculated using these methods and those measured during experiment, was performed.

  18. Experimental and theoretical oscillator strengths of Mg I for accurate abundance analysis

    CERN Document Server

    Rhodin, A Pehlivan; Nilsson, H; Jonsson, P

    2016-01-01

    Context. With the aid of stellar abundance analysis, it is possible to study the galactic formation and evolution. Magnesium is an important element to trace the alpha-element evolution in our Galaxy. For chemical abundance analysis, such as magnesium abundance, accurate and complete atomic data are essential. Inaccurate atomic data lead to uncertain abundances and prevent discrimination between different evolution models. Aims. We study the spectrum of neutral magnesium from laboratory measurements and theoretical calculations. Our aim is to improve the oscillator strengths ( f -values) of Mg I lines and to create a complete set of accurate atomic data, particularly for the near-IR region. Methods. We derived oscillator strengths by combining the experimental branching fractions with radiative lifetimes reported in the literature and computed in this work. A hollow cathode discharge lamp was used to produce free atoms in the plasma and a Fourier transform spectrometer recorded the intensity-calibrated high-r...

  19. Multi-objective experimental design for (13)C-based metabolic flux analysis.

    Science.gov (United States)

    Bouvin, Jeroen; Cajot, Simon; D'Huys, Pieter-Jan; Ampofo-Asiama, Jerry; Anné, Jozef; Van Impe, Jan; Geeraerd, Annemie; Bernaerts, Kristel

    2015-10-01

    (13)C-based metabolic flux analysis is an excellent technique to resolve fluxes in the central carbon metabolism but costs can be significant when using specialized tracers. This work presents a framework for cost-effective design of (13)C-tracer experiments, illustrated on two different networks. Linear and non-linear optimal input mixtures are computed for networks for Streptomyces lividans and a carcinoma cell line. If only glucose tracers are considered as labeled substrate for a carcinoma cell line or S. lividans, the best parameter estimation accuracy is obtained by mixtures containing high amounts of 1,2-(13)C2 glucose combined with uniformly labeled glucose. Experimental designs are evaluated based on a linear (D-criterion) and non-linear approach (S-criterion). Both approaches generate almost the same input mixture, however, the linear approach is favored due to its low computational effort. The high amount of 1,2-(13)C2 glucose in the optimal designs coincides with a high experimental cost, which is further enhanced when labeling is introduced in glutamine and aspartate tracers. Multi-objective optimization gives the possibility to assess experimental quality and cost at the same time and can reveal excellent compromise experiments. For example, the combination of 100% 1,2-(13)C2 glucose with 100% position one labeled glutamine and the combination of 100% 1,2-(13)C2 glucose with 100% uniformly labeled glutamine perform equally well for the carcinoma cell line, but the first mixture offers a decrease in cost of $ 120 per ml-scale cell culture experiment. We demonstrated the validity of a multi-objective linear approach to perform optimal experimental designs for the non-linear problem of (13)C-metabolic flux analysis. Tools and a workflow are provided to perform multi-objective design. The effortless calculation of the D-criterion can be exploited to perform high-throughput screening of possible (13)C-tracers, while the illustrated benefit of multi

  20. Pyrolysis of Municipal Green Waste: A Modelling, Simulation and Experimental Analysis

    Directory of Open Access Journals (Sweden)

    Mohammed J. Kabir

    2015-07-01

    Full Text Available Pyrolysis is the thermo-chemical conversion of carbonaceous feedstock in the absence of oxygen to produce bio-fuel (bio-oil, bio-char and syn-gas. Bio-fuel production from municipal green waste (MGW through the pyrolysis process has attracted considerable attention recently in the renewable energy sector because it can reduce greenhouse gas emissions and contribute to energy security. This study analyses properties of MGW feedstock available in Rockhampton city of Central Queensland, Australia, and presents an experimental investigation of producing bio-fuel from that MGW through the pyrolysis process using a short sealed rotary furnace. It was found from the experiment that about 19.97% bio-oil, 40.83% bio-char and 29.77% syn-gas can be produced from the MGW. Then, a four-stage steady state simulation model is developed for pyrolysis process performance simulation using Aspen Plus software. In the first stage, the moisture content of the MGW feed is reduced. In the second stage, the MGW is decomposed according to its elemental constituents. In the third stage, condensate material is separated and, finally, the pyrolysis reactions are modelled using the Gibbs free energy minimisation approach. The MGW’s ultimate and proximate analysis data were used in the Aspen Plus simulation as input parameters. The model is validated with experimentally measured data. A good agreement between simulation and experimental results was found. More specifically, the variation of modelling and experimental elemental compositions of the MGW was found to be 7.3% for carbon, 15.82% for hydrogen, 7.04% for nitrogen and 5.56% for sulphur. The validated model is used to optimise the biofuel production from the MGW as a function of operating variables such as temperature, moisture content, particle size and process heat air–fuel ratio. The modelling and optimisation results are presented, analysed and discussed.