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Sample records for age adjusted d-dimer

  1. The age-adjusted D-dimer safely excludes a high number of pulmonary embolisms in combination with four different clinical decision rules

    NARCIS (Netherlands)

    van Es, J.; Mos, I.C.M.; Douma, R.A.; Nizet, T.A.C.; Durian, M.; van Houten, A.A.; Hofstee, H.M.A.; ten Cate, H.; Ullmann, E.F.; Buller, H.R.; Huisman, M.V.; Kamphuisen, P.W.

    2011-01-01

    Background: Four different clinical decision rules (CDRs) (Wells score, Revised Geneva score (RGS), simplified Wells score and simplified RGS) safely exclude pulmonary embolism (PE), when combined with a normal D-dimer test. Recently, an age adjusted cut-off of the D-dimer (patient's age x 10 ig/L)

  2. Global Emergency Medicine Journal Club: A Social Media Discussion About the Age-Adjusted D-Dimer Cutoff Levels to Rule Out Pulmonary Embolism Trial

    OpenAIRE

    Rezaie, SR; Swaminathan, AK; Chan, T.; Shaikh, S; Lin, M.

    2015-01-01

    © 2015 American College of Emergency Physicians. Study objective: Annals of Emergency Medicine collaborated with an educational Web site, Academic Life in Emergency Medicine (ALiEM), to host an online discussion session featuring the 2014 Journal of the American Medical Association publication on the Age-Adjusted D-Dimer Cutoff Levels to Rule Out Pulmonary Embolism (ADJUST-PE) trial by Righini et al. The objective is to describe a 14-day (August 25 to September 7, 2014) worldwide academic dia...

  3. Age-dependent D-dimer cut-off to avoid unnecessary CT-exams for ruling-out pulmonary embolism; Altersangepasste Anhebung des D-Dimer-Grenzwertes zur Vermeidung unnoetiger CT-Untersuchungen bei Verdacht auf Lungenarterienembolie

    Energy Technology Data Exchange (ETDEWEB)

    Altmann, M.M.; Hoehne, M.; Herold, T. [HELIOS Klinikum Berlin-Buch (Germany). Radiology; Wrede, C.E. [HELIOS Klinikum Berlin-Buch (Germany). Emergency Department; Peetz, D. [HELIOS Klinikum Berlin-Buch (Germany). Laboratory Medicine; Stroszczynski, C. [University Medical Center, Radiology, Regensburg (Germany)

    2015-09-15

    To evaluate the effect of an age-dependent D-Dimer cut-off in patients who underwent a computed tomography pulmonary angiogram (CTPA) for suspected pulmonary embolism (PE). Retrospective application of an age-dependent D-dimer cut-off (age/100 in patients aged over 50) in 530 consecutive patients, both in- and outpatients, aged over 18, who underwent CTPA for suspected PE according to the guidelines. The application of an age-dependent D-dimer cut-off showed a now negative test-result in 17 of 530 patients (3.2 %). The proportion was 4.1 % (17 of 418) in patients aged over 50. None of these 17 cases was diagnosed with PE in CTPA, the false-negative rate was 0 %. The effect could be seen in outpatients (14 of 377 [3.7 %]) as well as in inpatients(3 of 153 [2.0 %]) with no statistically significant difference (p > 0.05). The application of an age-dependent D-dimer cut-off as part of the guideline-based algorithm for suspected PE reduced the number of necessary CTPA in outpatients as well as in inpatients.

  4. How to use D-dimer in acute cardiovascular care

    DEFF Research Database (Denmark)

    Giannitsis, Evangelos; Mair, Johannes; Christersson, Christina;

    2015-01-01

    D-dimer testing is important to aid in the exclusion of venous thromboembolic events (VTEs), including deep venous thrombosis and pulmonary embolism, and it may be used to evaluate suspected aortic dissection. D-dimer is produced upon activation of the coagulation system with the generation...... testing. For the exclusion of pulmonary embolism/deep vein thrombosis, age-adjusted cut-offs are recommend. Clinicians must be aware of the validated use of their hospital's D-dimer assay to avoid inappropriate use of this biomarker in routine care....

  5. Age-dependent D-dimer cut-off to avoid unnecessary CT-exams for ruling-out pulmonary embolism

    International Nuclear Information System (INIS)

    To evaluate the effect of an age-dependent D-Dimer cut-off in patients who underwent a computed tomography pulmonary angiogram (CTPA) for suspected pulmonary embolism (PE). Retrospective application of an age-dependent D-dimer cut-off (age/100 in patients aged over 50) in 530 consecutive patients, both in- and outpatients, aged over 18, who underwent CTPA for suspected PE according to the guidelines. The application of an age-dependent D-dimer cut-off showed a now negative test-result in 17 of 530 patients (3.2 %). The proportion was 4.1 % (17 of 418) in patients aged over 50. None of these 17 cases was diagnosed with PE in CTPA, the false-negative rate was 0 %. The effect could be seen in outpatients (14 of 377 [3.7 %]) as well as in inpatients(3 of 153 [2.0 %]) with no statistically significant difference (p > 0.05). The application of an age-dependent D-dimer cut-off as part of the guideline-based algorithm for suspected PE reduced the number of necessary CTPA in outpatients as well as in inpatients.

  6. Elevated d-dimer cut-off values for computed tomography pulmonary angiography—d-dimer correlates with location of embolism

    Science.gov (United States)

    Kubak, Mateuzs Piotr; Borthne, Arne; Ruud, Espen Asak; Ashraf, Haseem

    2016-01-01

    Background Acute pulmonary embolism (APE) is a potentially fatal condition, and making a timely diagnosis can be challenging. Computed tomography pulmonary angiography (CTPA) has become the modality of choice, and this contributes to the increasing load on emergency room CT scanners. Our purpose was to investigate whether an elevated d-dimer cut-off could reduce the demand for CTPA while maintaining a high sensitivity and negative predictive value (NPV). Methods We retrospectively reviewed all patients referred for CTPA with suspicion of APE in 2012, and collected d-dimer values and CTPA results. We investigated the diagnostic performance of d-dimer using a 0.5 mg/L cut-off and an age adjusted cut-off. We also evaluated a new and elevated cut-off. Cases were categorized according to their CTPA result into: no embolism, peripheral embolism, lobar embolism and central embolism. Finally we investigated a possible correlation between d-dimer values and location of embolism. Results We included 1,051 CTPAs, from which 216 (21%) showed pulmonary embolism. There were concomitant d-dimer analyses in 822 CTPA examinations. The current 0.5 mg/L cut-off achieved a sensitivity and NPV of 99%. The age-adjusted cut-off achieved a sensitivity and NPV of 98%, and our suggested cut-off of 0.9 mg/L achieved a sensitivity and NPV of 97%. Conclusions We conclude that the elevated d-dimer cut-off of 0.9 mg/L achieved a high sensitivity and NPV, while reducing the number of CTPA by 27%. The correlation between d-dimer values and location of embolisms supports the suggestion of an elevated d-dimer value. PMID:27386486

  7. Impact of d-Dimers on the Differential Diagnosis of Acute Chest Pain: Current Aspects Besides the Widely Known.

    Science.gov (United States)

    Hahne, Kathrin; Lebiedz, Pia; Breuckmann, Frank

    2014-01-01

    d-dimers are cleavage products of fibrin that occur during plasmin-mediated fibrinolysis of blood clots. In the emergency department, d-dimer measurement represents a valuable and cost-effective tool in the differential diagnosis of acute chest pain including the main life-threatening entities: acute coronary syndrome, pulmonary embolism, and acute aortic syndrome. Whereas the diagnostic and prognostic values of d-dimer testing in acute coronary syndrome is of less priority, increases of d-dimers are frequently found in venous thromboembolism and acute aortic syndromes, especially acute aortic dissection. As to the high negative predictive value of d-dimer in those disorders, patients with low to intermediate pretest probability may profit in terms of less necessity of further non-invasive or even invasive imaging, simultaneously reducing potential complications and healthcare-related costs. However, because of the low specificity of the different d-dimer tests in contrast to its frequent usage, adequate interpretation is required. Age-related adjustment of d-dimer levels may be used to increase its diagnostic power. PMID:25392700

  8. Relativity analysis of serum D-dimer content to stage and onset age of stroke%血浆D-二聚体含量与脑卒中病期、发病年龄的相关性研究

    Institute of Scientific and Technical Information of China (English)

    李东燕

    2002-01-01

    Objective To assess its significance to diagnosis, treating and prognosis of ischemic cerebrovascular disease by measuring plasma D dimer of 100 patients. Method By enzyme linked immunosorbent assay and double antibody sandwich assay, making color matching under 492 nm wavelength and to gain the plasma D dimer content value according to the standard curve.Result Serum D dimer content of acute cerebral infarction patients was significantly increase, which reflect increase of fibrinolysis activity and increase of thrombin production.It is a valuable index to hypercoagulation state and thrombosis. The Older the age, the higher the plasma D dimer content. Conclusion It is suggested that there was apparent change of D dimer in course of ischemic cerebrovascular diseases and in patients beyond 60, which engender hypercoagulation state leading to disease.

  9. Serum Potassium Levels Inversely Correlate with D-Dimer In Patients with Acute-Onset Atrial Fibrillation

    International Nuclear Information System (INIS)

    D-dimer values are frequently increased in patients with atrial fibrillation (AF) compared to subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. D-dimer values are frequently increased in patients with atrial fibrillation (AF) compared with subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. The aim of this study was to investigate correlations between D-dimer and serum potassium in acute-onset AF (AAF). To investigate the potential correlation between the values of serum potassium and D-dimer in patients with AAF, we retrospectively reviewed clinical and laboratory data of all emergency department visits for AAF in 2013. Among 271 consecutive AAF patients with D-dimer assessments, those with hypokalemia (n = 98) had significantly higher D-dimer values than normokalemic patients (139 versus 114 ng/mL, p = 0.004). The rate of patients with D-dimer values exceeding the diagnostic cut-off was higher in the group of patients with hypokalemia than in those with normal serum potassium (26.5% versus 16.2%; p = 0.029). An inverse and highly significant correlation was found between serum potassium and D-dimer (r = −0.21; p < 0.001), even after adjustments for age and sex (beta coefficient −94.8; p = 0.001). The relative risk for a positive D-dimer value attributed to hypokalemia was 1.64 (95% CI, 1.02 to 2.63; p = 0.040). The correlation remained statistically significant in patients free from antihypertensive drugs (r = −0.25; p = 0.018), but not in those taking angiotensin-receptor blockers, angiotensin-converting enzyme inhibitors, or diuretics. The inverse correlation between values of potassium and D-dimer in patients with AAF provides important and complementary information about the thromboembolic risk of these patients

  10. Serum Potassium Levels Inversely Correlate with D-Dimer In Patients with Acute-Onset Atrial Fibrillation

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    Cervellin, Gianfranco, E-mail: gcervellin@ao.pr.it; Bonfanti, Laura; Picanza, Alessandra; Lippi, Giuseppe [1Academic Hospital of Parma (Italy)

    2015-03-15

    D-dimer values are frequently increased in patients with atrial fibrillation (AF) compared to subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. D-dimer values are frequently increased in patients with atrial fibrillation (AF) compared with subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. The aim of this study was to investigate correlations between D-dimer and serum potassium in acute-onset AF (AAF). To investigate the potential correlation between the values of serum potassium and D-dimer in patients with AAF, we retrospectively reviewed clinical and laboratory data of all emergency department visits for AAF in 2013. Among 271 consecutive AAF patients with D-dimer assessments, those with hypokalemia (n = 98) had significantly higher D-dimer values than normokalemic patients (139 versus 114 ng/mL, p = 0.004). The rate of patients with D-dimer values exceeding the diagnostic cut-off was higher in the group of patients with hypokalemia than in those with normal serum potassium (26.5% versus 16.2%; p = 0.029). An inverse and highly significant correlation was found between serum potassium and D-dimer (r = −0.21; p < 0.001), even after adjustments for age and sex (beta coefficient −94.8; p = 0.001). The relative risk for a positive D-dimer value attributed to hypokalemia was 1.64 (95% CI, 1.02 to 2.63; p = 0.040). The correlation remained statistically significant in patients free from antihypertensive drugs (r = −0.25; p = 0.018), but not in those taking angiotensin-receptor blockers, angiotensin-converting enzyme inhibitors, or diuretics. The inverse correlation between values of potassium and D-dimer in patients with AAF provides important and complementary information about the thromboembolic risk of these patients.

  11. Serum Potassium Levels Inversely Correlate with D-Dimer In Patients with Acute-Onset Atrial Fibrillation

    Directory of Open Access Journals (Sweden)

    Gianfranco Cervellin

    2015-03-01

    Full Text Available Background: D-dimer values are frequently increased in patients with atrial fibrillation (AF compared to subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. Objective: D-dimer values are frequently increased in patients with atrial fibrillation (AF compared with subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. The aim of this study was to investigate correlations between D-dimer and serum potassium in acute-onset AF (AAF. Methods: To investigate the potential correlation between the values of serum potassium and D-dimer in patients with AAF, we retrospectively reviewed clinical and laboratory data of all emergency department visits for AAF in 2013. Results: Among 271 consecutive AAF patients with D-dimer assessments, those with hypokalemia (n = 98 had significantly higher D-dimer values than normokalemic patients (139 versus 114 ng/mL, p = 0.004. The rate of patients with D-dimer values exceeding the diagnostic cut-off was higher in the group of patients with hypokalemia than in those with normal serum potassium (26.5% versus 16.2%; p = 0.029. An inverse and highly significant correlation was found between serum potassium and D-dimer (r = −0.21; p < 0.001, even after adjustments for age and sex (beta coefficient −94.8; p = 0.001. The relative risk for a positive D-dimer value attributed to hypokalemia was 1.64 (95% CI, 1.02 to 2.63; p = 0.040. The correlation remained statistically significant in patients free from antihypertensive drugs (r = −0.25; p = 0.018, but not in those taking angiotensin-receptor blockers, angiotensin-converting enzyme inhibitors, or diuretics. Conclusions: The inverse correlation between values of potassium and D-dimer in patients with AAF provides important and complementary information about the thromboembolic risk of these patients.

  12. Factors associated with D-dimer levels in HIV-infected individuals.

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    Alvaro H Borges

    Full Text Available Higher plasma D-dimer levels are strong predictors of mortality in HIV+ individuals. The factors associated with D-dimer levels during HIV infection, however, remain poorly understood.In this cross-sectional study, participants in three randomized controlled trials with measured D-dimer levels were included (N = 9,848. Factors associated with D-dimer were identified by linear regression. Covariates investigated were: age, gender, race, body mass index, nadir and baseline CD4+ count, plasma HIV RNA levels, markers of inflammation (C-reactive protein [CRP], interleukin-6 [IL-6], antiretroviral therapy (ART use, ART regimens, co-morbidities (hepatitis B/C, diabetes mellitus, prior cardiovascular disease, smoking, renal function (estimated glomerular filtration rate [eGFR] and cystatin C and cholesterol.Women from all age groups had higher D-dimer levels than men, though a steeper increase of D-dimer with age occurred in men. Hepatitis B/C co-infection was the only co-morbidity associated with higher D-dimer levels. In this subgroup, the degree of hepatic fibrosis, as demonstrated by higher hyaluronic acid levels, but not viral load of hepatitis viruses, was positively correlated with D-dimer. Other factors independently associated with higher D-dimer levels were black race, higher plasma HIV RNA levels, being off ART at baseline, and increased levels of CRP, IL-6 and cystatin C. In contrast, higher baseline CD4+ counts and higher high-density lipoprotein cholesterol were negatively correlated with D-dimer levels.D-dimer levels increase with age in HIV+ men, but are already elevated in women at an early age due to reasons other than a higher burden of concomitant diseases. In hepatitis B/C co-infected individuals, hepatic fibrosis, but not hepatitis viral load, was associated with higher D-dimer levels.

  13. Evaluation of Serum D-dimer Levels in Children with Pneumonia

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    Nilgün Selçuk Duru

    2016-03-01

    Full Text Available Aim: The aim of this study was to investigate the relationship of plasma D-dimer levels with duration of hospitalization and radiological and laboratory findings in patients with pneumonia. Methods: Forty-seven patients with pneumonia (31 boys and 16 girls, mean age: 4.2±4.7 years were included in the study. The patients were divided into two groups according to duration of hospitalization and three groups according to radiological findings. D-dimer and other laboratory findings were compared between the groups. Results: The mean serum D-dimer level was 1333.5±1364.4 ng/L. There was no statistically significant difference in D-dimer, leukocyte, erythrocyte sedimentation rate (ESR and C-reactive protein (CRP between the groups divided according to duration of hospitalization. In addition, there was no statistically difference in D-dimer levels between the groups divided according to radiological findings. Age, percentage of neutrophils, ESR and fibrinogen levels were higher in patients with lobar pneumonia when compared with the other groups and CRP level was higher in lobar pneumonia group when compared to interstitial pneumonia group. D-dimer levels were negatively correlated with age and positively correlated with ESR, CRP, and fibrinogen. Conclusion: In our study, D-dimer levels were high in patient with pneumonia. Further studies with a larger number of patients are necessary to determine the role of D-dimer levels as an acutephase reactant in patients with pneumonia

  14. Plasma D-dimer concentration in patients with systemic sclerosis

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    Montagnana Martina

    2006-01-01

    Full Text Available Abstract Background Systemic sclerosis (SSc is an autoimmune disorder of the connective tissue characterized by widespread vascular lesions and fibrosis. Little is known so far on the activation of the hemostatic and fibrinolytic systems in SSc, and most preliminary evidences are discordant. Methods To verify whether SSc patients might display a prothrombotic condition, plasma D-dimer was assessed in 28 consecutive SSc patients and in 33 control subjects, matched for age, sex and environmental habit. Results and discussion When compared to healthy controls, geometric mean and 95% confidence interval (IC95% of plasma D-dimer were significantly increased in SSc patients (362 ng/mL, IC 95%: 361–363 ng/mL vs 229 ng/mL, IC95%: 228–231 ng/mL, p = 0.005. After stratifying SSc patients according to disease subset, no significant differences were observed between those with limited cutaneous pattern and controls, whereas patients with diffuse cutaneous pattern displayed substantially increased values. No correlation was found between plasma D-dimer concentration and age, sex, autoantibody pattern, serum creatinine, erythrosedimentation rate, nailfold videocapillaroscopic pattern and pulmonary involvement. Conclusion We demonstrated that SSc patients with diffuse subset are characterized by increased plasma D-dimer values, reflecting a potential activation of both the hemostatic and fibrinolytic cascades, which might finally predispose these patients to thrombotic complications.

  15. Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy

    Science.gov (United States)

    Baker, Jason V; Deeks, Steven G.; Wolfson, Julian; Wentworth, Deborah; Cozzi-Lepri, Alessandro; Cohen, Calvin J.; Phillips, Andrew; Lundgren, Jens D.; Neaton, James D.

    2016-01-01

    Background Despite effective antiretroviral treatment (ART), HIV-positive individuals are at increased risk of serious non-AIDS conditions (cardiovascular, liver and renal disease, and cancers), perhaps due in part to ongoing inflammation and/or coagulation. To estimate the potential risk reduction in serious non-AIDS conditions or death from any cause that might be achieved with treatments that reduce inflammation and/or coagulation, we examined associations of interleukin-6 (IL-6), D-dimer, and high-sensitivity C-reactive protein (hsCRP) levels with serious non-AIDS conditions or death in 3 large cohorts. Methods In HIV-positive adults on suppressive ART, associations of IL-6, D-dimer, and hsCRP levels at study entry with serious non-AIDS conditions or death were studied using Cox regression. Hazard ratios (HR) adjusted for age, gender, study, and regression dilution bias (due to within-person biomarker variability) were used to predict risk reductions in serious non-AIDS conditions or death associated with lower “usual” levels of IL-6 and D-dimer. Results Over 4.9 years of mean follow-up, 260 of the 3766 participants experienced serious non-AIDS conditions or death. IL-6, D-dimer and hsCRP were each individually associated with risk of serious non-AIDS conditions or death, HR = 1.45 (95% CI: 1.30 to 1.63), 1.28 (95% CI: 1.14 to 1.44), and 1.17 (95% CI: 1.09 to 1.26) per 2x higher biomarker levels, respectively. In joint models, IL-6 and D-dimer were independently associated with serious non-AIDS conditions or death, with consistent results across the 3 cohorts and across serious non-AIDS event types. The association of IL-6 and D-dimer with serious non-AIDS conditions or death was graded and persisted throughout follow-up. For 25% lower “usual” IL-6 and D-dimer levels, the joint biomarker model estimates a 37% reduction (95% CI: 28 to 46%) in the risk of serious non-AIDS conditions or death if the relationship is causal. Conclusions Both IL-6 and D-dimer

  16. Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy.

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    Birgit Grund

    Full Text Available Despite effective antiretroviral treatment (ART, HIV-positive individuals are at increased risk of serious non-AIDS conditions (cardiovascular, liver and renal disease, and cancers, perhaps due in part to ongoing inflammation and/or coagulation. To estimate the potential risk reduction in serious non-AIDS conditions or death from any cause that might be achieved with treatments that reduce inflammation and/or coagulation, we examined associations of interleukin-6 (IL-6, D-dimer, and high-sensitivity C-reactive protein (hsCRP levels with serious non-AIDS conditions or death in 3 large cohorts.In HIV-positive adults on suppressive ART, associations of IL-6, D-dimer, and hsCRP levels at study entry with serious non-AIDS conditions or death were studied using Cox regression. Hazard ratios (HR adjusted for age, gender, study, and regression dilution bias (due to within-person biomarker variability were used to predict risk reductions in serious non-AIDS conditions or death associated with lower "usual" levels of IL-6 and D-dimer.Over 4.9 years of mean follow-up, 260 of the 3766 participants experienced serious non-AIDS conditions or death. IL-6, D-dimer and hsCRP were each individually associated with risk of serious non-AIDS conditions or death, HR = 1.45 (95% CI: 1.30 to 1.63, 1.28 (95% CI: 1.14 to 1.44, and 1.17 (95% CI: 1.09 to 1.26 per 2x higher biomarker levels, respectively. In joint models, IL-6 and D-dimer were independently associated with serious non-AIDS conditions or death, with consistent results across the 3 cohorts and across serious non-AIDS event types. The association of IL-6 and D-dimer with serious non-AIDS conditions or death was graded and persisted throughout follow-up. For 25% lower "usual" IL-6 and D-dimer levels, the joint biomarker model estimates a 37% reduction (95% CI: 28 to 46% in the risk of serious non-AIDS conditions or death if the relationship is causal.Both IL-6 and D-dimer are independently associated with

  17. Factors associated with D-dimer levels in HIV-infected individuals

    DEFF Research Database (Denmark)

    Borges, Alvaro H; O'Connor, Jemma L; Phillips, Andrew N;

    2014-01-01

    [IL-6]), antiretroviral therapy (ART) use, ART regimens, co-morbidities (hepatitis B/C, diabetes mellitus, prior cardiovascular disease), smoking, renal function (estimated glomerular filtration rate [eGFR] and cystatin C) and cholesterol. RESULTS: Women from all age groups had higher D-dimer levels...... viruses, was positively correlated with D-dimer. Other factors independently associated with higher D-dimer levels were black race, higher plasma HIV RNA levels, being off ART at baseline, and increased levels of CRP, IL-6 and cystatin C. In contrast, higher baseline CD4+ counts and higher high...

  18. High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis

    Institute of Scientific and Technical Information of China (English)

    Aldo Spadaro; Antonino Ajello; Oscar Ferraù; Maria Antonietta Freni; Vincenza Tortorella; Carmela Morce; Agostino Fortiguerra; Paola Composto; Caterina Bonfiglio; Angela Alibrandi; Carmelo Luigiano; Giuseppe De Caro

    2008-01-01

    AIM:To measure plasma D-dimer levels in cirrhotic patients with and without ascites,assessing the effect of ascites resolution in D-dimer concentration.METHODS:Seventy consecutive cirrhotic patients(M=44,F=26,mean age 65 years,SD±13),observed from OdDber 2005 to March 2006 were enrolled.Circulating D-dimer Ievels were measured using a latex-enhanced,immunoturbidimetric test.In patients with ascites(,7=42)the test was repeated after ascites resolution.RESULTS:Ascites was present in 42 patients(group A)and absent in 28(group B).Group A patients had more advanced Iiver disease.Hepatocellular carcinoma(HCC)was diagnosed in 14 patients and was more frequent in group B.Above normaI range D-dimers were found in 45/70 patients.High D-dimers were more frequent in group A than in group B(P=0.001).High D-dimers were associated with presence of HCC(P=0.048)only in group B.Afber ascites resolution,obtained in all patienIs,mean D-dimer values decreased in those 34 patients with high basal levels(P=0.007),returning to normal in 17.CONCLUSION:In patients with Iiver cirrhosis,ascites and HCC are the main factors associated with increased fibrinolytic activiby.

  19. D-dimer is useful in assessing the vulnerable blood in elderly patients with coronary disease

    Institute of Scientific and Technical Information of China (English)

    Yansong Zheng; Qiang Zeng; Liping Zhang; Liufa Duan; Kunlun He; Qiufu Zheng

    2008-01-01

    Background and objective The value of D-dimer in the risk stratification of patients with coronary artery diseas(CAD)and the relationship between D-dimer and the diseased coronary arteries remains controversial or unclear.especially in the elderly.Thisstudy was to evaluate the usefulness of D-djmer as a biomarker in assessing the vuinerable blood in the elderly patients with coronarydisease.Methods Sixty elderly (≥60 years old)male patients with suspected CAD were enrolled in this prospective study.Patients were divided into CAD group(n=41,10 with stable angina and 31 with unstable angina)and control group(n=19)according to their coronary angiography Results Clinicalinformation including age,body mass index(BMI),smoking index,and thecomplications of Primary hypertension or diabetes.and CAD family history was collected.Venous blood was sampled serially for thedetermination of total cholesterol,HDL cholesterol,LDL cholesterol,triglycerides,apoAl,apoB,glucose,uric acid,homocysteine(Hey),hs-CRP,soluble thrombomodulin(sTM),and marker of fibrinolytic system and hypercoagulability,such as D-dimer,fibrinogen,etc.The extent of coronary atherosclerosis was assessed.using the Gensini scoring system on the basis of coronary angiography.Results Compared with the controls.the patients with CAD had significantly higher levels of D-dimer.D-dimer level wassignificantly correlated to age.hs-CR P.Hcy,and PAI-1.Patients with D-dimer levels in the top triplicate of D-dimer level hadsignificantly higher prevalence of unstable angina compared with patients in the lowest triplicate(OR=4.8,Z=3.28,P=0.001).In anordinal logistic regression.the OR value ofdeveloping more serious CAD augmented 3.1-foid with each increasing triplicate of D-dimer.Patients with unstable angina had a significantly higher level of D-dimer than the controls(P=0.005),and an increasing trend comparedwith patients with stable angina (P=0.059).whereas there was no difference between the patients with stable angina and

  20. Prognostic value of D-dimer in elderly patients with Pulmonary Embolism.

    Science.gov (United States)

    Polo Friz, Hernan; Buzzini, Chiara; Orenti, Annalisa; Punzi, Veronica; Molteni, Mauro; Primitz, Laura; Cavalieri d'Oro, Luca; Arpaia, Guido; Boracchi, Patrizia; Cimminiello, Claudio

    2016-10-01

    In a general population with acute Pulmonary Embolism (PE) elevated D-dimer concentrations associate with increased mortality. The aim of the study was to assess the ability of D-dimer to predict 30 and 90-days mortality in elderly patients with acute PE. Hemodynamically stable patients aged ≥65 years old with confirmed PE were included in this retrospective cohort study. A pulmonary computerized tomography angiography scan, D-dimer concentrations, simplified Pulmonary Embolism Severity Index (sPESI) variables and vital status were available for all patients. The study included 154 confirmed cases of PE (23.5 % of suspected), median age 79.1 years. D-dimer was higher in patients dead than in those alive at 30 (median 14,547 vs. 8340 ng/mL, p = 0.05) and 90 days (13,604 vs. 7973 ng/mL, p = 0.013). When adding D-dimer to sPESI, the discriminant capacity to predict mortality within 30 and 90 days was increased by 0.080 and 0.089, respectively. The contribution of D-dimer to the discriminating ability was NRI = 0.286 (95 % CI -0.198 to 0.770, p value: 0.247) at 30 days and NRI = 0.605 (95 % CI 0.223-0.988, p-value: 0.002) at 90 days.D-dimer concentration was associated with 30 and 90-days mortality and showed a higher discriminant capacity than sPESI alone to predict 90-days mortality. Adding D-dimer concentrations to sPESI score seems to improve its prognostic ability, supporting multivariable risk models as the best approach to estimate prognosis in elderly patients with PE. PMID:27357135

  1. Lifecourse social position and D-dimer; findings from the 1958 British birth cohort.

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    Faiza Tabassum

    Full Text Available The aim is to examine the association of lifecourse socioeconomic position (SEP on circulating levels of D-dimer. Data from the 1958 British birth cohort were used, social class was determined at three stages of respondents' life: at birth, at 23 and at 42 years. A cumulative indicator score of SEP (CIS was calculated ranging from 0 (always in the highest social class to 9 (always in the lowest social class. In men and women, associations were observed between CIS and D-dimer (P<0.05. Thus, the respondents in more disadvantaged social classes had elevated levels of D-dimer compared to respondents in less disadvantaged social class. In multivariate analyses, the association of disadvantaged social position with D-dimer was largely explained by fibrinogen, C-reactive protein and von Willebrand Factor in women, and additionally by smoking, alcohol consumption and physical activity in men. Socioeconomic circumstances across the lifecourse at various stages also contribute independently to raised levels of D-dimer in middle age in women only. Risk exposure related to SEP accumulates across life and contributes to raised levels of D-dimer. The association of haemostatic markers and social differences in health may be mediated by inflammatory and other markers.

  2. D-Dimer predicts prognosis and non-resectability in patients with pancreatic cancer: a prospective cohort study.

    Science.gov (United States)

    Stender, Mogens T; Larsen, Anders C; Sall, Mogens; Thorlacius-Ussing, Ole

    2016-07-01

    To examine the impact of plasma D-dimer levels in predicting 3-year survival and nonresectability in pancreatic cancer patients. Ninety-five patients were divided into three groups according to plasma D-dimer levels. Kaplan-Meier survival curves and hazard ratios were computed, and diagnostic indices of D-dimer in the prediction of resectability were assessed. The median survival among patients with low, medium and high D-dimer levels was 13.7 [95% confidence interval (CI): 10.2-19.6], 6.2 (95% CI: 2.0-15.1) and 2.4 months (95% CI: 1.4-3.3), respectively. The adjusted hazard ratio of death in the group of patients with high D-dimer levels was 2.2 (95% CI: 1.1-4.2). The positive and negative predictive values of D-dimer in the prediction of nonresectability were 89% (95% CI: 77-96%) and 48% (95% CI: 33- 63%), respectively. An elevated D-dimer level is associated with reduced survival in pancreatic cancer and predicts nonresectability. PMID:27182687

  3. Relationship between disease severity and D-dimer levels measured with two different methods in pulmonary embolism patients

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    Coskun Funda

    2010-06-01

    Full Text Available Abstract Pulmonary embolism (PE is diagnosed with increasing frequency nowadays due to advances in the diagnostic methods and the increased awareness of the disease. There is a tendency to use non invasive diagnostic methods for all diseases. D-dimer is a fibrin degradation product. We aimed to detect the relationship between disease severity and the D-dimer levels measured with two different methods. We compared D-dimer levels in cases of massive vs. non-massive PE. A total of 89 patients who were diagnosed between 2006 and 2008 were included in the study. Group 1 included patients whose D-dimer levels were measured with the immunoturbidimetric polyclonal antibody method (D-dimerPLUS®, while Group 2 patients made use of the immunoturbidimetric monoclonal antibody method (InnovanceD-DIMER®. In each group, the D-dimer levels of those with massive and non-massive PE were compared, using the Mann Whitney U test. The mean age of Group 1 (25 F/26 M was 56.0 ± 17.9 years, and that of Group 2 (22 F/16 M was 52.9 ± 17.9 years. There was no statistical difference in gender and mean age between the two groups (p > 0.05. In Group 1, the mean D-dimer level of massive cases (n = 7 was 1444.9 ± 657.9 μg/L and that of nonmassive PE (n = 34 was 1304.7 ± 350.5 μg/L (p > 0.05. In Group 2, the mean D-dimer level of massive cases (n = 6 was 9.7 ± 2.2 mg/L and that of non-massive PE (n = 32 was 5.9 ± 1.3 mg/L (p

  4. The relationship between D-dimer level and the development of atrial fibrillation in patients with systolic heart failure.

    Science.gov (United States)

    Zorlu, Ali; Akkaya, Emre; Altay, Hakan; Bektasoglu, Gokhan; Turkdogan, Kenan Ahmet; Sincer, Isa; Vuruskan, Ertan; Cınar, Ziynet; Tandogan, Izzet; Yilmaz, Mehmet Birhan

    2012-05-01

    Heart failure (HF) is one of the most common and leading cause of death worldwide. Clinical trials provide evidence that the development of atrial fibrillation (AF) is a marker of poor prognosis in patients with HF. Furthermore, elevated D-dimer level is associated with increased cardiovascular mortality independent of AF in HF patients. We investigated whether plasma D-dimer levels in patients with hospitalized systolic HF could predict development of AF. A total of 150 consecutive patients with sinus rhythm who admitted to the emergency department with hospitalized systolic HF were evaluated. All hospitalized patients were obtained D-dimer levels within the first 24 h following admission. Atrial fibrillation developed in 31 (20.7%) patients during follow-up period of 6.3 ± 5 months. Patients who developed atrial fibrillation had significantly increased levels of D-dimer [608 (339-1,022) ng/ml versus 1,100 (608-2,599) ng/ml, P = 0.001]. Optimal cut-off level of D-dimer to predict development of AF was found to be >792 ng/ml. D-dimer >792 ng/ml, right ventricular dilatation, age, systolic pulmonary pressure, left atrium size, moderate to severe tricuspid regurgitation, and beta blocker usage were found to have prognostic significance in univariate analysis. In multivariate Cox proportional-hazards model, D-dimer levels >792 ng/ml (HR = 3.019, P = 0.006), and right ventricular dilatation (HR = 8.676, P = 0.003) were associated with an increased risk of new-onset AF. In conclusion, D-dimer could predict development of AF in patients with hospitalized systolic HF. PMID:22139027

  5. High Pretreatment D-Dimer Levels Correlate with Adverse Clinical Features and Predict Poor Survival in Patients with Natural Killer/T-Cell Lymphoma

    Science.gov (United States)

    Sun, Peng; Yan, Shu-mei; Liu, Pan-pan; Li, Zhi-ming; Jiang, Wen-qi

    2016-01-01

    Pretreatment plasma D-dimer levels have been reported to predict survival in several types of malignancies. The aim of this study was to evaluate the prognostic value of D-dimer levels in patients with newly diagnosed natural killer/T-cell lymphoma (NKTCL). The cut-off value of D-dimer to predict survival was set as 1.2 μg/mL based on the receiver operating curve analysis. Patients with a D-dimer level ≥ 1.2 μg/mL had significantly more adverse clinical features, including poor performance status, advanced stage diseases, B symptoms, elevated serum lactic dehydrogenase levels, involvement of regional lymph nodes, more extranodal diseases, and higher International Prognostic Index and natural killer/T-cell lymphoma prognostic index scores. A D-dimer level ≥ 1.2 μg/mL was significantly associated with inferior 3-year overall survival (OS, 13.0 vs. 68.5%, P < 0.001). In the multivariate analysis, a D-dimer level ≥ 1.2 μg/mL remained an independent predictor for worse OS (HR: 3.13, 95% CI: 1.47–6.68, P = 0.003) after adjusting for other confounding prognostic factors. Among patients with Ann Arbor stage I-II diseases, those with a D-dimer level ≥ 1.2 μg/mL had a significantly worse survival than those with a D-dimer level < 1.2 μg/mL (3 year-OS: 76.2 vs. 22.2%, P < 0.001). Survival of early-stage patients with a high D-dimer level was similar to that of the advanced-stage patients. In conclusion, pretreatment plasma D-dimer level may serve as a simple but effective predictor of prognosis in patients with NKTCL. PMID:27032016

  6. Large D-Dimer Fluctuation in Normal Pregnancy: A Longitudinal Cohort Study of 4,117 Samples from 714 Healthy Danish Women

    Science.gov (United States)

    Hedengran, Katrine K.; Andersen, Malene R.; Stender, Steen; Szecsi, Pal B.

    2016-01-01

    Introduction. D-dimer levels increase throughout pregnancy, hampering the usefulness of the conventional threshold for dismissing thromboembolism. This study investigates the biological fluctuation of D-dimer in normal pregnancy. Methods. A total of 801 healthy women with expected normal pregnancies were recruited. D-dimer was repeatedly measured during pregnancy, at active labor, and on the first and second postpartum days. Percentiles for each gestational week were calculated. Each individual D-dimer was normalized by transformation into percentiles for the relevant gestational age or delivery group. The range in percentage points during the pregnancy and the delivery was calculated, and reference intervals were calculated for each pregnancy trimester, during vaginal delivery and scheduled and emergency cesarean section, and for the first and second day postpartum. Results. D-dimer increased during pregnancy; the maximal fluctuation was approximately 20 percentile points in approximately half of the women. In one out of ten women, the D-dimer values fluctuated by more than 50 percentile points. Conclusions. Due to the biological variation in D-dimer within each individual woman during normal pregnancy, repeated D-dimer measurements are of no clinical use in the evaluation of thromboembolic events during pregnancy. PMID:27190521

  7. The Diagnostic Value of D-dimer, Procalcitonin and CRP in Acute Appendicitis

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    Bulent Kaya, Baris Sana, Cengiz Eris, Koray Karabulut, Orhan Bat, Riza Kutanis

    2012-01-01

    Full Text Available BACKGROUND: The early diagnosis of acute abdomen is of great importance. To date, several inflammatory markers have been used for the diagnosis of acute abdominal conditions, including acute appendicitis. The aim of this study was to evaluate the diagnostic utility of D-dimer, Procalcitonin (PCT and C-reactive protein (CRP measurements in the acute appendicitis.METHODS: This prospective study was conducted between March 1st, 2010 and July 1st, 2011. In this period, seventy-eight patients were operated with the diagnosis of acute appendicitis, and D-dimer, PCT and CRP levels of the patients were measured. The patients were grouped as phlegmonous appendicitis (Group 1, gangrenous appendicitis (Group 2, perforated appendicitis (Group 3 and negative appendectomy (Group 4 according to the surgical findings and histopathological results.RESULTS: Of 78 patients, 54 (69.2 % were male and 24 (30.8 % were female, and the mean age was 25.4 ± 11.1 years (range, 18 to 69 years. 66 (84.6 % patients had increased leukocyte count (white blood cell count. The PCT values were higher than the upper normal limit in 20 (25.6% patients, followed by D-dimer in 22 (28.2 % patients and CRP in 54 (69.2 % patients. The diagnostic value of leukocyte count and CRP in acute appendicitis was higher than that of the other markers, whereas leukocyte count showed very low specificity. CRP values were higher in perforated appendicitis when compared with the phlegmonous appendicitis (p<0.05. However, PCT and D-dimer showed lower diagnostic values (26% and 31%, respectively.CONCLUSION: An increase in CRP levels alone is not sufficient to make the diagnosis of acute appendicitis. However, CRP levels may differentiate between phlegmonous appendicitis and perforated appendicitis. Due to their low sensitivity and diagnostic value, PCT and D-dimer are not better markers than CRP for the diagnosis of acute appendicitis.

  8. D-dimer is useful in the diagnosis of cortical venous sinus thrombosis

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    Misra Usha

    2009-01-01

    Full Text Available Background: Estimations of D-dimer correlate with deep vein thrombosis and pulmonary thromboembolism and may serve as a marker of cortical venous sinus thrombosis (CVST. Aim: To study the usefulness of D-dimer in the diagnosis of CVST. Materials and Methods: A total of 26 patients with CVST were subjected to a detailed medical history and neurological evaluation. A cranial MRI was carried out on a 1.5T scanner using T1, T2, and DWI sequences and two-dimensional time of flight MR venography. D-dimer was estimated using a rapid latex agglutination slide test using monoclonal antibodies. Results: The age of patients ranged between 16 and 70 years old (median 31 years old; 8 were males and were examined after a mean duration of 22 days of symptoms. Cortical venous thrombosis was attributed to puerperium in 4 patients, infection in 5 patients, and pregnancy, dehydration, insect bite, and migraine in 1 patient each. Superior sagittal sinus was involved in 15 patients, transverse sinus in 16 patients, straight sinus in 3 patients, sigmoid sinus in 7 patients, and cavernous and deep system in 1 patient each. A total of 12 patients had more than one sinus involvement. D-dimer was positive in 20 patients and correlated with the duration of symptoms but not with the extent of sinus thrombosis and the outcome. Conclusion: D-dimer is useful in patients suspected of CVST and patients with positive test results should be urgently sent for MR imaging.

  9. Role of D-Dimer, Fibrinogen and DDimer/Fibrinogen Rate in the Diagnosis of Pulmonary Embolism

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    Sureyya Yilmaz1

    2016-04-01

    Full Text Available Objective: The migration of a blood clot from the systemic circulation to pulmonary veins is called pulmonary embolism (PE. Pulmonary embolism is difficult to diagnose. The aim of the present study is to investigate the utility and diagnostic contribution of d-dimer, fibrinogen level, and Ddimer/Fibrinogen (D/F rate which are quick, non-invasive, affordable and easily obtainable laboratory tests in PE. Methods: We have evaluated the diagnostic value of D/F rate in 118 patients who were suspected to have PE. Diagnosis of PE was made by computerized tomographic pulmonary angiography. D-dimer level was above normal in all patients. Initially, Wells clinical scoring was applied on the patients and their d-dimer and fibrinogen levels were measured. Results: Seventy seven patients were detected as PE positive (+ and 41 were detected as PE negative (-. Forty-eight of the cases (40.7% were male; the average age was 49.77±19.46 (15-86 years. Between PE (+ and PE (- patients, d-dimer, fibrinogen, and D/F rate median values and standard derivations were detected to be different and statistically significant. Conclusion: According to this study approach to the patients with suspected from PE, D/F ratio is valuable than d-dimer, and fibrinogen level is significantly lower in patients with PE (+ than patients with PE (-.

  10. Preoperative plasma D-dimer is a predictor of one-year survival in colorectal cancer patients: a prospective clinical cohort study

    DEFF Research Database (Denmark)

    Stender, Mogens; Larsen, Torben Bjerregaard; Frøkjær, J.B.;

    PURPOSE: The study examined if preoperative plasma D-dimer level was associated with the postoperative cumulative incidence of deep venous thrombosis in patients with colorectal cancer admitted for intended curative surgery. METHODS: In 176 consecutive patients with newly-diagnosed colorectal...... cancer and absence of preoperative deep venous thrombosis, we measured the preoperative plasma D-dimer levels and performed compression ultrasonography for deep venous thrombosis prior to surgery, as well as one week, one month, and one year after surgery. RESULTS: The cumulative incidence of deep venous...... thrombosis up to one year after surgery was 20 percent (95 percent confidence interval, 12 to 31 percent) in the positive D-dimer group compared with 5 percent (95 percent confidence interval, 2 to 12 percent) in the negative D-dimer group. The adjusted hazard ratio of deep venous thrombosis in the positive...

  11. The relationship between level of plasma D-dimer and survival time in metastatic gastric cancer patients%血浆D-二聚体水平与转移性胃癌患者生存期的关系

    Institute of Scientific and Technical Information of China (English)

    Xiaodong Jiao; Jianxin Qian; Guanzhen Yu; Rui Li; Zhan Wang; Jin Wang; Xiaoqiang Gu; Jiejun Wang

    2011-01-01

    Objective: The principal purpose of this study was to determine the relationship between level of plasma D-dimer and survival time in metastatic gastric cancer patients. Methods: We retrospectively collected the data of plasma D-dimer in metastatic gastric cancer patients admitted in our Department (Department of Oncology, The Affiliated Changzheng Hospital, The Second Military Medical University, Shanghai, China) from October 2006 to October 2008 and analyzed the relationship between level of plasma D-dimer and survival time along with other clinicopathologic parameters. Results: A total of 82 patients were studied in our research, 52 were males and 30 females, and the mean age was 57 years. The 48 cases had a normal plasma D-dimer level (< 300 μg/L) and 34 had a high plasma D-dimer level (≥ 300 μg/L). In the normal and high plasma D-dimer level groups, the mean survival times were 10.9 (95% CI: 9.8-12.2) months and 6.8 (95% CI: 4.4-7.6) months respectively, and the difference was statistically significant. Conclusion: Metastatic gastric cancer patients with high plasma D-dimer level had significantly shorter survival time than those with normal plasma D-dimer level. Level of plasma D-dimer can be referred as a potential predictor in metastatic gastric cancer patients.

  12. Values of the Wells and Revised Geneva Scores Combined with D-dimer in Diagnosing Elderly Pulmonary Embolism Patients

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    Dan-Jie Guo

    2015-01-01

    Full Text Available Background: Pulmonary embolism (PE can be difficult to diagnose in elderly patients because of the coexistent diseases and the combination of drugs that they have taken. We aimed to compare the clinical diagnostic values of the Wells score, the revised Geneva score and each of them combined with D-dimer for suspected PE in elderly patients. Methods: Three hundred and thirty-six patients who were admitted for suspected PE were enrolled retrospectively and divided into two groups based on age (≥65 or <65 years old. The Wells and revised Geneva scores were applied to evaluate the clinical probability of PE, and the positive predictive values of both scores were calculated using computed tomography pulmonary arteriography as a gold standard; overall accuracy was evaluated by the area under the curve (AUC of receiver operator characteristic curve; the negative predictive values of D-dimer, the Wells score combined with D-dimer, and the revised Geneva score combined with D-dimer were calculated. Results: Ninety-six cases (28.6% were definitely diagnosed as PE among 336 cases, among them 56 cases (58.3% were ≥65 years old. The positive predictive values of Wells and revised Geneva scores were 65.8% and 32.4%, respectively (P < 0.05 in the elderly patients; the AUC for the Wells score and the revised Geneva score in elderly was 0.682 (95% confidence interval [CI]: 0.612-0.746 and 0.655 (95% CI: 0.584-0.722, respectively (P = 0.389. The negative predictive values of D-dimer, the Wells score combined with D-dimer, and the revised Geneva score combined with D-dimer were 93.7%, 100%, and 100% in the elderly, respectively. Conclusions: The diagnostic value of the Wells score was higher than the revised Geneva score for the elderly cases with suspected PE. The combination of either the Wells score or the revised Geneva score with a normal D-dimer concentration is a safe strategy to rule out PE.

  13. Values of the Wells and Revised Geneva Scores Combined with D-dimer in Diagnosing Elderly Pulmonary Embolism Patients

    Institute of Scientific and Technical Information of China (English)

    Dan-Jie Guo; Can Zhao; Ya-Dan Zou; Xu-Hang Huang; Jing-Min Hu; Lin Guo

    2015-01-01

    Background:Pulmonary embolism (PE) can be difficult to diagnose in elderly patients because of the coexistent diseases and the combination of drugs that they have taken.We aimed to compare the clinical diagnostic values of the Wells score,the revised Geneva score and each of them combined with D-dimer for suspected PE in elderly patients.Methods:Three hundred and thirty-six patients who were admitted for suspected PE were enrolled retrospectively and divided into two groups based on age (_>65 or <65 years old).The Wells and revised Geneva scores were applied to evaluate the clinical probability of PE,and the positive predictive values of both scores were calculated using computed tomography pulmonary arteriography as a gold standard;overall accuracy was evaluated by the area under the curve (AUC) of receiver operator characteristic curve;the negative predictive values of D-dimer,the Wells score combined with D-dimer,and the revised Geneva score combined with D-dimer were calculated.Results:Ninety-six cases (28.6%) were definitely diagnosed as PE among 336 cases,among them 56 cases (58.3%) were >65 years old.The positive predictive values of Wells and revised Geneva scores were 65.8% and 32.4%,respectively (P < 0.05) in the elderly patients;the AUC for the Wells score and the revised Geneva score in elderly was 0.682 (95% confidence interval [CI]:0.612-0.746) and 0.655 (95% CI:0.584-0.722),respectively (P =0.389).The negative predictive values of D-dimer,the Wells score combined with D-dimer,and the revised Geneva score combined with D-dimer were 93.7%,100%,and 100% in the elderly,respectively.Conclusions:The diagnostic value of the Wells score was higher than the revised Geneva score for the elderly cases with suspected PE.The combination of either the Wells score or the revised Geneva score with a normal D-dimer concentration is a safe strategy to rule out PE.

  14. Relationship between Plasma D-Dimer Concentration and Three-Dimensional Ultrasound Placental Volume in Women at Risk for Placental Vascular Diseases: A Monocentric Prospective Study

    Science.gov (United States)

    Fanget, Cécile; Chauleur, Céline; Stadler, Amandine; Presles, Emilie; Varlet, Marie-Noëlle; Gris, Jean-Christophe

    2016-01-01

    Introduction The aim of this study was to correlate placental volumes deduced from three-dimensional ultrasound and virtual organ computer-aided analysis (VOCAL) software with systemic concentrations of D-dimer and soluble endothelial protein C receptor (sEPCR). Methods This was a monocentric experimental prospective study conducted from October 2008 to July 2009. Forty consecutive patients at risk of placental vascular pathology (PVP) recurrence or occurrence were included. Placental volumes were systematically measured three times (11–14, 16–18 and 20–22 weeks of gestation (WG)) by two independent sonographers. D-dimers and sEPCR plasma concentrations were measured using ELISA kits (Enzyme Linked ImmunoSorbent Assay). Results Eleven patients had a PVP. The plasma D-dimer level was positively correlated with placental volume (r = 0.45, p < 0.001). A smaller placental volume and placental quotient was evidenced in women who developed a PVP at the three gestational ages, and the difference was more pronounced during the third exam (20 WG). No obvious correlation could be demonstrated between the development of a PVP and the levels of D-dimer and sEPCR. There was no significant difference in the values of placental volumes measured by the two sonographers. Conclusion The placenta growth could be a major determinant of the elevation of D-dimer during pregnancy. Consideration of placental volume could allow for modulation of the D-dimer concentrations for restoring their clinical interest. PMID:27294274

  15. Changes in D-dimer and inflammatory biomarkers before ischemic events in patients with peripheral artery disease: The BRAVO Study.

    Science.gov (United States)

    McDermott, Mary McGrae; Liu, Kiang; Green, David; Greenland, Philip; Tian, Lu; Kibbe, Melina; Tracy, Russell; Shah, Sanjiv; Wilkins, John T; Huffman, Mark; Zhao, Lihui; Huang, Chiang-Ching; Auerbach, Amanda; Liao, Yihua; Skelly, Christopher L; McCarthy, Walter; Lloyd Jones, Donald

    2016-02-01

    Whether circulating biomarker levels increase shortly before an ischemic heart disease (IHD) event is unknown. We studied whether levels of D-dimer, C-reactive protein (CRP), and serum amyloid A (SAA) are higher within 2 months of an IHD event compared to time periods more than 2 months before the IHD event. We assembled 595 participants with peripheral artery disease (PAD) and followed them for up to 3 years. Blood samples were obtained every 2 months. The primary outcome was IHD events: myocardial infarctions, unstable angina, or IHD death. We used a nested case-control design. Fifty participants (cases) had events and were each matched by age, sex, duration in the study, and number of blood draws to two controls without events. Among cases, the mean D-dimer value of 1.105 obtained within 2 months of the event was higher than values obtained 10 months (0.68 mg/L, pevent. Compared to controls, median D-dimer levels in cases were higher 4 months (p=0.017), 6 months (p=0.005), and 8 months (p=0.028) before the event. Values of CRP and SAA obtained within two months of an IHD event not consistently higher than values obtained during the prior months. In PAD participants with an IHD event, D-dimer was higher within 2 months of the event, compared to most values obtained 10 to 32 months previously. D-dimer was also higher in cases as compared to controls during most visits within 8 months of the IHD event.

  16. Age-adjusted Labor Force Participation Rates, 1960-2045.

    Science.gov (United States)

    Szafran, Robert F.

    2002-01-01

    A proposed new age-adjusted measure for calculating labor force participation rate eliminates the effect of changes in the age distribution. According to the new criterion, increases in women's labor force participation from 1960-2000 would have been even greater of shifts in the age distribution had not occurred. (Contains 12 references.) (JOW)

  17. Correlation analysis between plasma D-dimer levels and orthopedic trauma severity

    Institute of Scientific and Technical Information of China (English)

    ZHANG Li-dan; LIU Hong-bo; LI Yu-neng; MA Hai-mei; LIU Ya-bo; WANG Man-yi

    2012-01-01

    Background The correlation between the plasma D-dimer level and deep vein thrombosis has not been conclusive in various studies.The aim of this research was to study the relationship between plasma D-dimer levels and the severity of orthopedic trauma by retrospective examination of orthopedic trauma cases.Methods Clinically acute trauma and non-acute trauma patients were selected and their plasma D-dimer levels were measured.Plasma D-dimer levels in patients of these two groups were compared.The relationship between the plasma D-dimer level and the severity of the trauma was also studied.Results There were 548 cases in the acute trauma group and 501 cases in the non-acute trauma group.The levels of plasma D-dimer were significantly higher in the acute trauma group than in the non-acute trauma group (P <0.01).In the acute trauma group,the correlation between the D-dimer level and the number of fractures was a positive linear correlation (r=0.9532).Conclusions Elevated plasma D-dimer is common in trauma patients.The D-dimer level and the number of fractures in the trauma patients are closely correlated.D-dimer is not only an indicator for the diagnosis of deep vein thrombosis and pulmonary embolus,but also an indicator of the severity of trauma in acute trauma patients.

  18. D-D dimer levels in patients with sickle cell disease during bone pain crises and in the steady state

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    Fakunle EE

    2012-05-01

    Full Text Available Eyitayo Emmanuel Fakunle,1 Kapoona Iwara Ibiang Eteng,2 Wuraola Adebola Shokunbi21Department of Pathology, King Edward VII Memorial Hospital, Bermuda; 2Department of Hematology, University College Hospital, Ibadan, NigeriaObjective: To determine the presence of ongoing thrombosis by measuring the D-D dimer levels in bone pain crises (BPCs and in the steady state of patients with sickle cell disease, comparing these levels with those in individuals with normal hemoglobin (HbAA in southwest Nigeria.Study design, patients, and methods: The study design involved 38 patients with homozygous sickle cell anemia (HbSS and 78 adults with the HbAA phenotype, seen at the Hematology Day Care and Accident and Emergency units of the University College Hospital, Ibadan, Nigeria. The TintElize kit was used to quantitatively determine human D-D dimer levels in the plasma with enzyme immunoassay.Results: The mean D-D dimer level measured of the 78 individuals with HbAA was 73.59 ng/mL. The mean D-D dimer level of the patients with HbSS during BPCs was 4002.40 ng/mL, while the mean level in the same patients in the steady state measured 6 weeks after their BPCs, with no other painful crisis episode before the sample was collected, was 1320.00 ng/mL.Conclusion: This study demonstrated a significant increase in the D-D dimer levels of patients with HbSS in the steady state, when compared with those of individuals with HbAA of the same age and sex distribution. There was also an approximate threefold increase in the D-D dimer levels in the same patients with HbSS during BPCs. This confirms the activation of coagulation and fibrinolytic systems in patients with HbSS in the steady state, which is further escalated during BPCs. A multicenter study on the use of anticoagulants in BPCs in patients with sickle cell disease is required.Keywords: anticoagulant, dimer, sickle cell disease, BPC, Nigeria, chronic hemolytic anemia

  19. Genetic Predictors of Fibrin D-Dimer Levels in Healthy Adults

    OpenAIRE

    Smith, N. L.; J.E. Huffman; Strachan, D. P.; Huang, J.; A. Dehghan; Trompet, S.; Lopez, L.M. (Lorna M.); Shin, S.-Y.; Baumert, J.; Vitart, V; Bis, J.C.; Wild, S.H.; Rumley, A; Yang, Q.; Uitterlinden, A G

    2011-01-01

    Background-Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide association search. Methods and Results-A genome-wide investigation of the genomic correlates of plasma D-dimer levels was conducted among 21 052 European-ancestry adults. Plasma levels of D-dimer were measu...

  20. Brug af D-dimer til at udelukke dyb venøs trombose i overekstremiteterne

    DEFF Research Database (Denmark)

    Ahler-Toftehøj, Hans-Ulrik; Mikkelsen, Peter

    2009-01-01

    D-dimer is often used to exclude deep venous thrombosis, primarily in the lower extremities. We describe a 38-year-old man who had deep venous thrombosis in the left vena subclavia in spite of a normal D-dimer. Only one inconclusive survey compares the value of D-dimer and upper extremity deep...... venous thrombosis. We conclude that where deep venous thrombosis of the upper extremities is suspected, you cannot rely on the D-dimer value, but should examine the patient using other modalities such as colour Doppler ultrasound. Udgivelsesdato: 2009-Sep...

  1. D-dimer: a useful tool in gauging optimal duration of oral anticoagulant therapy?

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    M. Silingardi

    2013-05-01

    Full Text Available BACKGROUND AND AIM OF THE STUDY Optimal duration of oral anticoagulant therapy (OAT in idiopathic venous thromboembolism (VTE is unknown. Indefinite OAT carries an unacceptable risk of major bleeding and prospective studies have demonstrated that OAT is no longer protective after its withdrawal. How to identify the patients at risk for recurrence? D-dimer is a marker of thrombin activity. Early prospective studies showed that elevated D-dimer levels after anticoagulation had a highly predictive value for a recurrent episode. Does D-dimer assay have a role in gauging the appropriate duration of anticoagulant therapy? The PROLONG study tries to answer this question. METHOD D-dimer assay was performed one month after stopping anticoagulation. Patiens with normal D-dimer levels did not resume anticoagulation while patients with elevated D-dimer levels were randomized to discontinue or resume anticoagulation. Study end-points was the composite of recurrent VTE and major bleeding during an average follow-up of 1.4 years. RESULTS The rate of recurrence is significantly higher in patients with elevated D-dimer levels who discontinued anticoagulation. Resuming anticoagulation in this cohort of patients markedly reduces recurrent events without increasing major bleeding. DISCUSSION AND CONCLUSIONS PROLONG study is provocative, because D-dimer assay is simple, thus not requiring dedicated laboratory facilities. D-dimer test has otherwise high sensitivity but low specificity in VTE diagnosis. Aspecifically elevated D-dimer levels are available in the elderly and the majority of patients included in the study were > 65 years old, thus introducing a possible selection bias. Nonetheless the results of the study are useful for the clinician. Prolongation of vitamin K antagonists in patients with elevated D-dimer levels one month after discontinuation of OAT for a first unprovoked episode of VTE results in a favourable risk-benefit relationship. Probably this

  2. Genetic predictors of fibrin D-dimer levels in healthy adults

    NARCIS (Netherlands)

    N.L. Smith (Nicholas); J.E. Huffman (Jennifer E.); D.P. Strachan (David); J. Huang (Jian); A. Dehghan (Abbas); S. Trompet (Stella); L.M. Lopez (Lorna M.); S.Y. Shin (So Youn); J. Baumert (Jens); V. Vitart (Veronique); J.C. Bis (Joshua); S.H. Wild (Sarah); A. Rumley (Ann); Q. Yang (Qiong Fang); A.G. Uitterlinden (André); D.J. Stott (David. J.); G. Davies (Gareth); A.M. Carter (Angela M.); B. Thorand (Barbara); O. Polašek (Ozren); B. McKnight (Barbara); H. Campbell (Harry); A.R. Rudnicka (Alicja); M.H. Chen (Min-hsin); B.M. Buckley (Brendan M.); S.E. Harris (Sarah); A. Peters (Annette); D. Pulanic (Drazen); T. Lumley (Thomas); A.J.M. de Craen (Anton J.M.); D.C. Liewald (David C.); C. Gieger (Christian); I. Ford (Ian); A.J. Gow (Alan J.); M. Luciano (Michelle); D.J. Porteous (David J.); X. Guo (Xiuqing); N. Sattar (Naveed); A. Tenesa (Albert); M. Cushman (Mary Ann); P.E. Slagboom (Eline); P.M. Visscher (Peter M.); T.D. Spector (Tim); T. Illig (Thomas); I. Rudan (Igor); E.G. Bovill (Edwin G.); A.F. Wright (Alan); W.L. McArdle (Wendy); G.H. Tofler (Geoffrey); A. Hofman (Albert); R.G.J. Westendorp (Rudi); J.M. Starr (John); P.J. Grant (Peter J.); M. Karakas (Mahir); N.D. Hastie (Nicholas D.); B.M. Psaty (Bruce); J.F. Wilson (James); G.D.O. Lowe (Gordon); C.J. O'Donnell (Christopher); J.C.M. Witteman (Jacqueline); J.W. Jukema (Jan Wouter); I.J. Deary (Ian); N. Soranzo (Nicole); W. Koenig (Wolfgang); C. Hayward (Caroline)

    2011-01-01

    textabstractBACKGROUND: Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wi

  3. D-dimer testing to determine the duration of anticoagulation therapy

    NARCIS (Netherlands)

    G. Palareti; B. Cosmi; C. Legnani; A. Tosetto; C. Brusi; A. Iorio; V. Pengo; A. Ghirarduzzi; C. Pattacini; S. Testa; A.W.A. Lensing; A. Tripodi

    2006-01-01

    BACKGROUND: The optimal duration of oral anticoagulation in patients with idiopathic venous thromboembolism is uncertain. Testing of D-dimer levels may play a role in the assessment of the need for prolonged anticoagulation. METHODS: We performed D-dimer testing 1 month after the discontinuation of

  4. Knowledge of the D-dimer test result influences clinical probability assessment of pulmonary embolism

    NARCIS (Netherlands)

    R.A. Douma; J.B.F. Kessels; H.R. Büller; V.E.A. Gerdes

    2010-01-01

    Background: In patients with suspected pulmonary embolism (PE), an unlikely or non-high probability assessment combined with a normal D-dimer test can safely exclude the diagnosis. We studied the influence of early D-dimer knowledge on clinical probability assessment. Methods: A questionnaire was se

  5. Markedly elevated plasma D-dimer and the prevalence of acute pulmonary embolus

    Directory of Open Access Journals (Sweden)

    Andrew W. Bowman

    2011-11-01

    Full Text Available Objective. To evaluate if increasingly elevated levels of plasma D-dimer are associated with higher prevalence of acute pulmonaryembolus (PE. Patients and Methods. A retrospective study wasconducted evaluating all PE protocol CT examinations performed inlow-to-intermediate risk emergency department and hospitalized patients during 2007. All PE protocol CT reports were reviewed for thepresence or absence of acute PE. Th e charts of all of these subjectswere then reviewed for quantitative plasma D-dimer values, measuredin mg/ml Fibrinogen Equivalent Units, drawn within one day prior tothe CT exam. Th e prevalence of acute PE at different D-dimer threshold results was then evaluated using D-dimer groups as follows: < 1.0 mg/ml, ≥ 1.0 but < 2.0 mg/ml, ≥ 2.0 but < 4.0 mg/ml, and ≥ 4.0 mg/ml. Results. 943 PE protocol CT exams were reviewed. 410 subjectshad D-dimer values drawn before their CT exams; 30 (7.3% of thesewere positive for acute PE. As D-dimer values became increasingly elevated, the prevalence of acute PE increased accordingly. In particular, D-dimer elevation ≥4.0 mg/ml was almost 94% specific for acute PE by CT criteria. Conclusion. Increased elevation of plasma D-dimer is associated with increased prevalence of acute PE in low-to-intermediate risk patients.

  6. Changes in fibrin D-dimer, fibrinogen, and protein S during pregnancy

    DEFF Research Database (Denmark)

    Hansen, Anette Tarp; Andreasen, Birgitte Horst; Salvig, Jannie Dalby;

    2010-01-01

    Background. Pregnancy is a hypercoagulable state with a 5- to 10- fold higher risk of venous thromboembolism. Existing reference intervals for fibrin D-dimer (D-dimer), functional fibrinogen (fibrinogen) and protein S, free antigen (protein S) are based on non-pregnant patients and reference...... intervals for pregnant patients are warranted. Objectives. The aim of the present study was to contribute to the establishment of reference intervals for D-dimer, fibrinogen and protein S during pregnancy and to discuss the use of the analyses during pregnancy. Methods. We included 55 healthy pregnant women...... in gestational week 11–17, with normal current pregnancy. Blood samples were collected in gestational weeks 11–17, 21–27 and 34–37. The three plasma parameters D-dimer, fibrinogen and protein S were analysed by STA-R Evolution®. Results. A significant rise in D-dimer was found from first to second trimester (p...

  7. The current role and future prospects of D-dimer biomarker.

    Science.gov (United States)

    Soomro, Armaghan Y; Guerchicoff, Alejandra; Nichols, Dru J; Suleman, Javed; Dangas, George D

    2016-07-01

    D-dimers have been discovered as by-products of fibrinolysis. In situations where the fundamental pathology is associated with increased thrombolytic activity, D-dimer assays could serve an integral role in the clinical workup, and have an already established role in the diagnosis of clinical disorders of venous thromboembolism, and disseminated intravascular coagulation. However, there is growing literature suggesting that this is not the only clinical scenario where D-dimers may be of significance. They may also become an important biomarker in coronary and carotid artery atherosclerosis and aortic diseases. Being a non-invasive and quick means of diagnosis, D-dimers are a cost-effective tool used for diagnosing diseases. With the future being steered in the direction of preventive cardiology, it is imperative for clinicians to understand how to effectively utilize biomarkers in order to diagnose disorders. In this context, we review D-dimer's origin, current clinical utility, and potential future applications. PMID:27533759

  8. Screening for pulmonary embolism with a D-dimer assay: do we still need to assess clinical probability as well?

    OpenAIRE

    Hammond, Christopher J; Hassan, Tajek B.

    2005-01-01

    Clinical risk stratification and D-dimer assay can be of use in excluding pulmonary embolism in patients presenting to emergency departments but many D-dimer assays exist and their accuracy varies. We used clinical risk stratification combined with a quantitative latex-agglutination D-dimer assay to screen patients before arranging further imaging if required. Retrospective analysis of a sequential series of 376 patients revealed that no patient with a D-dimer of

  9. Shifting Up Cutoff Value of D-Dimer in the Evaluation of Pulmonary Embolism: A Viable Option? Possible Risks and Benefits

    Directory of Open Access Journals (Sweden)

    Bennidor Raviv

    2012-01-01

    Full Text Available Objectives. To evaluate the viability of the possibility to use a higher D-dimer value than the one used today in the clinical algorithms evaluating patients suspected to have pulmonary embolism. Methods. A retrospective analysis of 300 serial patients for whom D-dimer values were taken during a 10 month period in the emergency room of a tertiary medical center. Results. Our analysis showed that it may be safe and cost effective to use a D-dimer value of 900 ng/ml rather than the value of 500 ng/ml accepted today, with sensitivity of 94.4%. In younger patients [under 40 years] the sensitivity reached was even higher—100%. Conclusions. Raising cutoff values of D-dimer in screening for pulmonary embolism seems a viable option. There may be a place for “tailoring” cutoff values according individual patient characteristics, such as according age groups. More studies of the subject are warranted.

  10. Monoclonal antibodies with equal specificity to D-dimer and high-molecular-weight fibrin degradation products

    Science.gov (United States)

    Kogan, Alexander E.; Mukharyamova, Kadriya S.; Bereznikova, Anastasia V.; Filatov, Vladimir L.; Koshkina, Ekaterina V.; Bloshchitsyna, Marina N.; Katrukha, Alexey G.

    2016-01-01

    Fibrin degradation results in the formation of fibrin degradation products (FDPs) of different molecular weights, which include D-dimer. Commercial D-dimer assays recognize multiple forms of FDP with different specificity. As a result, the absence of an international D-dimer standard and the marked discrepancy in the D-dimer values in the same samples measured by assays from different manufacturers have become the primary problems that clinicians face in the D-dimer determination. We consider that an assay with equal specificity to all FDP forms regardless of their molecular weights could help to solve these problems. We aimed to produce mAbs that could equally recognize high-molecular-weight FDP (HMW FDP) and D-dimer. mAbs against D-dimer were produced. The HMW FDP/D-dimer ratios in plasma samples were analyzed following protein separation by gel filtration using the developed fluoroimmunoassay. A sandwich immunoassay with equal specificity to HMW FDP and D-dimer was developed and applied to determine HMW FDP/D-dimer ratios in patients with different diseases. Although the HMW FDP levels prevailed in thrombotic patients, the FDP and D-dimer levels were comparable in septic patients. Meanwhile, the D-dimer levels often exceeded the HMW FDP levels in patients who had undergone surgery. The ‘D-dimer’ levels that were detected by different assays also varied greatly depending on the assay specificities to FDP and D-dimer. Our findings show that the introduction of assays with equal specificities to FDP and D-dimer in clinical practice is a possible way of standardizing D-dimer measurements. PMID:26656897

  11. Using D-Dimer to Diagnose Painless Acute Aortic Dissection: A Case Report

    Directory of Open Access Journals (Sweden)

    Caroline Barniol

    2011-01-01

    Case Presentation. We report the case of a 66-year-old Caucasian male who presented a syncope immediately followed by a left-arm weakness while driving his car. Clinical examination was normal, but bilateral jugular vein distension was noted. Electrocardiogram and chest radiography were unremarkable. Among blood tests performed, troponin I test result was negative, and D-dimer test concentration was >4000 ng/mL. Since D-dimer test result was positive, chest computer tomography angiogram was performed and found a thoracic aortic dissection. Conclusion. Our case report shows that acute aortic dissection diagnosis is difficult and must be associated with the interpretation of various clinical signs and D-dimer measurement. It could be helpful for the emergency physician to have a pretest probability D-dimer like in pulmonary embolism diagnosis.

  12. Kadar Fibrinogen Dan D-Dimer Pada Wanita Dengan Sindroma Ovarium Polikistik

    OpenAIRE

    Lubis, Hilma Putri

    2015-01-01

    BACKGROUND : Polycystic Ovarian Syndrome (PCOS) is a dysfunction of ovarium with polycystic ovarian morphology and hiperandrogenism state. Fibrinogen dan D-dimer are hemostatic factors. Fibrinogen considered as an independent risk factor for cardiovascular disease. D-dimer, final product of cross-linked fibrin degeneration by plasmin in fibrinolytic system, also contributes to cardiovascular and miscarriage risk especially in PCOS patient. OBJECTIVE : To find the difference of fibrinogen a...

  13. Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis*

    OpenAIRE

    Criado, Paulo Ricardo; Antinori, Lidi Che Leon; Maruta, Celina Wakisaka; dos Reis, Vitor Manoel Silva

    2013-01-01

    BACKGROUND It has been demonstrated that neutrophils, eosinophils and monocytes, under appropriated stimulus, may express tissue factor and therefore, activate the extrinsic pathway of coagulation. We performed a transversal and case-control study of patients with chronic urticaria and patients with psoriasis, in our outpatient clinic to evaluate the production of D-dimer. OBJECTIVE To evaluate D-dimer serum levels in patients with chronic urticaria and its possible correlation with disease a...

  14. Capnometry in suspected pulmonary embolism with positive D-dimer in the field

    OpenAIRE

    Rumpf, Tadeja Hernja; Križmarić, Miljenko; Grmec, Štefek

    2009-01-01

    Introduction Pulmonary embolism (PE) is one of the greatest diagnostic challenges in prehospital emergency setting. Most patients with suspected PE have a positive D-dimer and undergo diagnostic testing. Excluding PE with additional non-invasive tests would reduce the need for further imaging tests. We aimed to determine the effectiveness of combination of clinical probability and end-tidal carbon dioxide (PetCO2) for evaluation of suspected PE with abnormal concentrations of D-dimer in preho...

  15. Value of D-Dimers in patients with acute aortic dissection

    Institute of Scientific and Technical Information of China (English)

    Chuncai Xue; Yigang Li

    2007-01-01

    Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.

  16. Qualitative D-Dimer in deep vein thrombosis: A single center prospective study from Kashmir India

    Directory of Open Access Journals (Sweden)

    Davinder Pal Singh

    2012-01-01

    Full Text Available Objective: The aim of our study was to study the significance of qualitative D-dimer in the diagnosis of deep vein thrombosis. Study Design: Prospective analysis. Setting: Tertiary care hospital. Materials and Methods: One hundred and twenty nine patients of suspected deep vein thrombosis were included in the study and further categorized as likely or unlikely to have deep vein thrombosis on Wells scoring system. The patients in both the likely and unlikely categories were then randomly assigned to undergo D-dimer testing (D-dimer group or to undergo ultrasound imaging alone (control group. The patients with pre text clinical probability score as unlikely and with negative D-dimer test were considered not to have DVT. The primary event was recurrent venous thromboembolism in both the groups during three months of follow-up. Results: A total of one hundred and twenty nine patients with suspected DVT were included in the study. Sixty five patients were randomly assigned to D-dimer group and sixty four to the doppler group. The diagnosis of DVT was established in 41 (31.78% patients. Among patients in whom DVT was ruled out by the initial diagnostic evaluation one case of deep vein thrombosis was confirmed in the D-dimer group (1/55, 1.8%; 95% confidence interval, 1.6 to 5.2% and two cases in the Doppler group (2/51, 3.92%; 95% confidence interval, 1.5 to 9.34% during three months of follow-up. The use of D-dimer resulted in lesser number of USG (0.66 tests per person in the D-dimer group as compared to (1.23 tests per person in the Doppler group. Forty patients (31% in the D-dimer group did not require ultrasound imaging. Conclusion: The diagnostic performance of qualitative D-dimer assay combined with a clinical pre text probability score can also rule out DVT safely in low probability scores without significantly compromising safety.

  17. D-dimer assays - A help or hindrance in suspected pulmonary thromboembolism assessment?

    Directory of Open Access Journals (Sweden)

    H K Bayes

    2011-01-01

    Full Text Available Background : Suspected pulmonary thromboembolism (PTE is a common presentation to acute medical units and can cause diagnostic difficulty. National guidelines on PTE management highlight the need for clinical probability assessment and D-dimer assays to ensure appropriate use of diagnostic imaging. D-dimers are used widely in UK hospitals, yet concern exists regarding their misuse. Aims : In this study we aimed to assess the impact of the introduction of D-dimer assays, combined with clinical probability assessment, for evaluation of suspected PTE in our unit. Materials and Methods : This was a prospective audit of all patients presenting with suspected PTE over two 12-week periods, exactly 1 year apart. D-dimers were introduced into our unit between these two periods. We recorded the clinical probability score, potential causes of false-positive D-dimer assay, diagnostic imaging result, patient outcome, admission rates, and length of inpatient stay. Statistical Analysis : Categorical variables were compared using a 2 x 2 chi-square test or Fisher′s exact test. Groups were compared utilizing the two-sample t-test or Mann-Whitney U test. Results : A total of 190 patients were included in the study; 65% were female. PTE was confirmed in 8.4%. Patients in both audit periods were comparable with regard to suitability for D-dimer measurement. Following D-dimer introduction, 40 out of 110 patients in period 2 could be discharged directly from the emergency department. Of those admitted to hospital, the median length of stay was significantly reduced in period 2 (3 days in period 1 vs 1 day in period 2; P=0.0007. Use of diagnostic imaging was significantly reduced following the introduction of D-dimers (90% in period 1 vs 40% in period 2; P<0.0001. The positive diagnostic yield for PTE on CT pulmonary angiogram (CTPA increased significantly from 10% in period 1 to 23% in period 2 (P=0.039. Conclusion : D-dimers must be used judiciously in the

  18. D-dimer assay in Egyptian patients with Gaucher disease: correlation with bone and lung involvement.

    Science.gov (United States)

    Sherif, Eman M; Tantawy, Azza A G; Adly, Amira A M; Kader, Hossam A; Ismail, Eman A R

    2011-04-01

    Gaucher disease is the most frequent lysosomal storage disorder. Bone and lung involvement are two major causes of morbidity in this disease. D-dimer is a reliable indicator of active microvascular thrombosis, even in patients without overt hypercoagulation. This study aimed to assess D-dimer levels in Gaucher disease, correlating this marker to clinical characteristics and radiological parameters to investigate its role as a potential predictor for the occurrence and severity of skeletal and pulmonary manifestations. The study population consisted of 56 Egyptian patients with Gaucher disease, 36 had type 1 Gaucher disease (64.3%) and 20 had type 3 Gaucher disease (35.7%). Thirty healthy individuals were enrolled as a control group. D-dimer levels were significantly higher in all patients with Gaucher disease compared with controls (P < 0.001). Patients with type 3 showed significantly higher D-dimer concentrations compared with type 1 (P < 0.001). Pulmonary involvement was present in a significant proportion among type 3 Gaucher patients (P < 0.05), whereas bone changes were present in a higher percentage in type 1 compared with type 3 Gaucher patients. D-dimers were significantly higher in patients with abnormal MRI findings of the long bones and in those with ground glass appearance on high-resolution computerized tomography of the chest compared with patients with normal radiology (P < 0.001). Splenectomized patients displayed significantly higher D-dimer levels compared with nonsplenectomized patients (P < 0.001). Our results suggest that D-dimer is significantly elevated in Gaucher disease, particularly type 3, and may be considered as a potential marker of risk prediction of bone and lung involvement that could be used to monitor treatment response.

  19. D-dimer testing: advantages and limitations in emergency medicine for managing acute venous thromboembolism.

    Science.gov (United States)

    Siragusa, Sergio

    2006-01-01

    D-dimer values can be rapidly determined and used for the management of acute venous thromboembolism (VTE). However, its role in the setting of emergency still remains unclear and inappropriate testing is a significant clinical problem. This review discusses the currently used assays, clinical indications, and limitations of D-dimer measurement. Studies in English language were identified by searching PubMed from December 1985 to December 2005. Available literature on D-dimer was identified from Medline, along with cross referencing from the reference lists of major articles and reviews on this subject. Among 56 articles collected, 14 papers, 4 overviews and 1 systemic review were selected accordingly to predefined criteria. Data synthesis shows that D-dimer testing has sufficient diagnostic accuracy for ruling out acute VTE if used in combination with standardised clinical judgement. D-dimer seems to be also a useful tool for managing suspected VTE patients in absence of immediate imaging. Attention should be paid to exclude conditions that may affect the accuracy of the test, such as concomitant disease, heparin administration and symptom duration >15 days. Although enzyme-linked immunosorbent assay determination has the highest accuracy, immunoturbidimetric assay seems the most suitable on an emergency basis because of its rapid performance. In conclusion, at present D-dimer testing can be safely used in the management of acute VTE in emergency medicine. However, because of its heterogeneity related to the method used and setting implemented, it is preferable to assess D-dimer accuracy before its implementation in management strategies for VTE. PMID:16941816

  20. Activation of coagulation system and d-dimer levels in children with acute leukemia

    Directory of Open Access Journals (Sweden)

    Harun Wijaya

    2014-07-01

    Full Text Available Background D-dimer is a molecule as result of breaking down of excessive fibrin formation from the activation of coagulation system. There is evidence of increased activation of coagulation in patients with acute leukemia which was showed by the increment of d-dimer levels. Objective To evaluate the incidence of activation of coagulation system in children with acute leukemia before receiving chemotherapy. Method This cross-sectional study was performed at Dr. Cipto Mangunkusumo Hospital. All newly-diagnosed children with acute leukemia were included in this study, prior to their receiving any chemotherapy treatment. Blast count, prothrombin time (PTT, activated partial thromboplastin time (APTT, and D-dimer levels were examined after the diagnosis was confirmed by morphology and immunophenotyping studies on bone marrow specimens. Results Out of 22 subjects, 13 subjects had increased D-dimer values. The median D-dimer level of this elevated group was 1,000 (range 500-14,700 ng/mL. In the acute myeloblastic leukemia (AML patients, activation of coagulation was found in 7 out of 8 subjects. The median D-dimer levels was 950 (range 100-14,700 ng/mL. In the acute lymphocytic leukemia (ALL patients, 6 out of 14 subjects had increased activation of coagulation with median D-dimer level of 300 (range 100-3,800 ng/mL. Nine out of 10 subjects with blast cells on peripheral blood smear had a median D-dimer level of 1,000 (range 500-3,800 ng/mL. Both PT and APTT were found normal in all subjects. Conclusion Activation of coagulation system occurs at the time of diagnosis as shown by increased D-dimer levels. The characteristics of activation of coagulation system are different between ALL and AML subjects, as well as between subjects with positive and negative blast counts on peripheral blood smears. Despite the increased activation of coagulation, PT and APTT remain normal. [Paediatr Indones. 2014;54:227-31.].

  1. CT Findings of Disease with Elevated Serum D-Dimer Levels in an Emergency Room Setting

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Ji Youn; Kwon, Woo Cheol; Kim, Young Ju [Dept. of Radiology, Wonju Christian Hospital, Yensei University Wonju College of Medicine, Wonju (Korea, Republic of)

    2012-01-15

    Pulmonary embolism and deep vein thrombosis are the leading causes of elevated serum D-dimer levels in the emergency room. Although D-dimer is a useful screening test because of its high sensitivity and negative predictive value, it has a low specificity. In addition, D-dimer can be elevated in various diseases. Therefore, information on the various diseases with elevated D-dimer levels and their radiologic findings may allow for accurate diagnosis and proper management. Herein, we report the CT findings of various diseases with elevated D-dimer levels in an emergency room setting, including an intravascular contrast filling defect with associated findings in a venous thromboembolism, fracture with soft tissue swelling and hematoma formation in a trauma patient, enlargement with contrast enhancement in the infected organ of a patient, coronary artery stenosis with a perfusion defect of the myocardium in a patient with acute myocardial infarction, high density of acute thrombus in a cerebral vessel with a low density of affected brain parenchyma in an acute cerebral infarction, intimal flap with two separated lumens in a case of aortic dissection, organ involvement of malignancy in a cancer patient, and atrophy of a liver with a dilated portal vein and associated findings.

  2. D-Dimer Levels before HIV Seroconversion Remain Elevated Even after Viral Suppression and Are Associated with an Increased Risk of Non-AIDS Events.

    Science.gov (United States)

    Freiberg, Matthew S; Bebu, Ionut; Tracy, Russell; So-Armah, Kaku; Okulicz, Jason; Ganesan, Anuradha; Armstrong, Adam; O'Bryan, Thomas; Rimland, David; Justice, Amy C; Agan, Brian K

    2016-01-01

    The mechanism underlying the excess risk of non-AIDS diseases among HIV infected people is unclear. HIV associated inflammation/hypercoagulability likely plays a role. While antiretroviral therapy (ART) may return this process to pre-HIV levels, this has not been directly demonstrated. We analyzed data/specimens on 249 HIV+ participants from the US Military HIV Natural History Study, a prospective, multicenter observational cohort of >5600 active duty military personnel and beneficiaries living with HIV. We used stored blood specimens to measure D-dimer and Interleukin-6 (IL-6) at three time points: pre-HIV seroconversion, ≥6 months post-HIV seroconversion but prior to ART initiation, and ≥6 months post-ART with documented HIV viral suppression on two successive evaluations. We evaluated the changes in biomarker levels between time points, and the association between these biomarker changes and future non-AIDS events. During a median follow-up of 3.7 years, there were 28 incident non-AIDS diseases. At ART initiation, the median CD4 count was 361cells/mm3; median duration of documented HIV infection 392 days; median time on ART was 354 days. Adjusted mean percent increase in D-dimer levels from pre-seroconversion to post-ART was 75.1% (95% confidence interval 24.6-148.0, p = 0.002). This increase in D-dimer was associated with a significant 22% increase risk of future non-AIDS events (p = 0.03). Changes in IL-6 levels across time points were small and not associated with future non-AIDS events. In conclusion, ART initiation and HIV viral suppression does not eliminate HIV associated elevation in D-dimer levels. This residual pathology is associated with an increased risk of future non-AIDS diseases.

  3. D-Dimer Levels before HIV Seroconversion Remain Elevated Even after Viral Suppression and Are Associated with an Increased Risk of Non-AIDS Events.

    Science.gov (United States)

    Freiberg, Matthew S; Bebu, Ionut; Tracy, Russell; So-Armah, Kaku; Okulicz, Jason; Ganesan, Anuradha; Armstrong, Adam; O'Bryan, Thomas; Rimland, David; Justice, Amy C; Agan, Brian K

    2016-01-01

    The mechanism underlying the excess risk of non-AIDS diseases among HIV infected people is unclear. HIV associated inflammation/hypercoagulability likely plays a role. While antiretroviral therapy (ART) may return this process to pre-HIV levels, this has not been directly demonstrated. We analyzed data/specimens on 249 HIV+ participants from the US Military HIV Natural History Study, a prospective, multicenter observational cohort of >5600 active duty military personnel and beneficiaries living with HIV. We used stored blood specimens to measure D-dimer and Interleukin-6 (IL-6) at three time points: pre-HIV seroconversion, ≥6 months post-HIV seroconversion but prior to ART initiation, and ≥6 months post-ART with documented HIV viral suppression on two successive evaluations. We evaluated the changes in biomarker levels between time points, and the association between these biomarker changes and future non-AIDS events. During a median follow-up of 3.7 years, there were 28 incident non-AIDS diseases. At ART initiation, the median CD4 count was 361cells/mm3; median duration of documented HIV infection 392 days; median time on ART was 354 days. Adjusted mean percent increase in D-dimer levels from pre-seroconversion to post-ART was 75.1% (95% confidence interval 24.6-148.0, p = 0.002). This increase in D-dimer was associated with a significant 22% increase risk of future non-AIDS events (p = 0.03). Changes in IL-6 levels across time points were small and not associated with future non-AIDS events. In conclusion, ART initiation and HIV viral suppression does not eliminate HIV associated elevation in D-dimer levels. This residual pathology is associated with an increased risk of future non-AIDS diseases. PMID:27088215

  4. D-Dimer Levels before HIV Seroconversion Remain Elevated Even after Viral Suppression and Are Associated with an Increased Risk of Non-AIDS Events

    Science.gov (United States)

    Freiberg, Matthew S.; Bebu, Ionut; Tracy, Russell; So-Armah, Kaku; Okulicz, Jason; Ganesan, Anuradha; Armstrong, Adam; O’Bryan, Thomas; Rimland, David; Justice, Amy C.; Agan, Brian K.

    2016-01-01

    The mechanism underlying the excess risk of non-AIDS diseases among HIV infected people is unclear. HIV associated inflammation/hypercoagulability likely plays a role. While antiretroviral therapy (ART) may return this process to pre-HIV levels, this has not been directly demonstrated. We analyzed data/specimens on 249 HIV+ participants from the US Military HIV Natural History Study, a prospective, multicenter observational cohort of >5600 active duty military personnel and beneficiaries living with HIV. We used stored blood specimens to measure D-dimer and Interleukin-6 (IL-6) at three time points: pre-HIV seroconversion, ≥6 months post-HIV seroconversion but prior to ART initiation, and ≥6 months post-ART with documented HIV viral suppression on two successive evaluations. We evaluated the changes in biomarker levels between time points, and the association between these biomarker changes and future non-AIDS events. During a median follow-up of 3.7 years, there were 28 incident non-AIDS diseases. At ART initiation, the median CD4 count was 361cells/mm3; median duration of documented HIV infection 392 days; median time on ART was 354 days. Adjusted mean percent increase in D-dimer levels from pre-seroconversion to post-ART was 75.1% (95% confidence interval 24.6–148.0, p = 0.002). This increase in D-dimer was associated with a significant 22% increase risk of future non-AIDS events (p = 0.03). Changes in IL-6 levels across time points were small and not associated with future non-AIDS events. In conclusion, ART initiation and HIV viral suppression does not eliminate HIV associated elevation in D-dimer levels. This residual pathology is associated with an increased risk of future non-AIDS diseases. PMID:27088215

  5. Elevation in D-dimer concentrations is positively correlated with gestation in normal uncomplicated pregnancy

    Directory of Open Access Journals (Sweden)

    Jeremiah ZA

    2012-08-01

    Full Text Available Zaccheaus A Jeremiah,1 Teddy C Adias,2 Margaret Opiah,3 Siyeoforiye P George,4 Osaro Mgbere,5 Ekere J Essien61Department of Medical Laboratory Sciences, Niger Delta University, Wilberforce Island, Nigeria; 2Bayelsa State College of Health Technology, Ogbia-Town, Nigeria; 3Department of Maternal and Child Health, Faculty of Nursing, Niger Delta University, Wilberforce Island, Nigeria; 4Postgraduate Hematology Unit, Rivers State University of Science and Technology, Port Harcourt, Nigeria; 5Houston Department of Health and Human Services, Houston, TX, USA; 6Institute of Community Health, University of Houston, Houston, TX, USABackground: D-dimer levels have been reported to increase progressively during pregnancy, but how this affects Nigerian women is not well known.Objective: This study aims to determine the D-dimer concentration and its relationship to other coagulation parameters among pregnant women in Port Harcourt, Nigeria.Method: In a cross-sectional observational study conducted in Port Harcourt, Nigeria, 120 pregnant women and 60 nonpregnant controls, drawn from a tertiary health institution in the Niger Delta, Nigeria, were assessed, using the standard procedures, for the following parameters: D-dimer concentration, prothrombin time, activated partial thromboplastin time, platelet count, hemoglobin, and packed cell volume.Results: The median D-dimer concentration of 153.1 ng/mL in the pregnant group was found to be significantly elevated when compared with the control value of 118.5 ng/mL (t = 2.348, P = 0.021. Conversely, there was a marked depression in the platelet count among pregnant women (193.5 × 109/L when compared with 229.0 × 109/L in the control group (t = 3.424; P = 0.001. There was no statistically significant difference in the values for the prothrombin time and the activated partial thromboplastin time between pregnant and nonpregnant women. D-dimer values correlated positively and significantly with gestation (r = 0

  6. Impact of d-Dimers on the Differential Diagnosis of Acute Chest Pain: Current Aspects Besides the Widely Known

    OpenAIRE

    Hahne, Kathrin; Lebiedz, Pia; Breuckmann, Frank

    2014-01-01

    d-dimers are cleavage products of fibrin that occur during plasmin-mediated fibrinolysis of blood clots. In the emergency department, d-dimer measurement represents a valuable and cost-effective tool in the differential diagnosis of acute chest pain including the main life-threatening entities: acute coronary syndrome, pulmonary embolism, and acute aortic syndrome. Whereas the diagnostic and prognostic values of d-dimer testing in acute coronary syndrome is of less priority, increases of d-di...

  7. Construction and expression of D-dimer and GPIIb/IIIa single-chain bispecific antibody

    OpenAIRE

    DAN, ZHAOKUI; Tan, Zui; Xia, Hongli; WU, GAN

    2013-01-01

    The aim of this study was to construct a plasmid expressing glycoprotein IIb-IIIa (GPIIb/IIIa) and D-dimer single-chain bispecific antibody for the targeted therapy of thrombosis. The phosphorylated gene encoding the anti-GPIIb/IIIa single-chain variable fragment (scFv) and the gene encoding the anti-D-dimer scFv were amplified by PCR and linked in tandem by blunt-end ligation. The recombinant plasmid was transfected into the competent cell line HB2151 and identified by PCR and DNA sequencing...

  8. Combined use of the National Early Warning Score and D-dimer levels to predict 30-day and 365-day mortality in medical patients

    DEFF Research Database (Denmark)

    Nickel, Christian H; Kellett, John; Cooksley, Tim;

    2016-01-01

    AIM: To investigate the combined use of NEWS and D-dimer levels to predict the 30-day and 365-day mortality rates of a cohort of Danish patients with complete follow-up. METHODS: Post-hoc retrospective observational study of acutely admitted medical patients aged 18 years or older who had D......-dimer measured within 6h after arrival to two medical admission units in Denmark. RESULTS: The final study population consisted of 1201 patients with a median age of 65.0 years (range 18.0-107.0 years), and 44.7% were of male sex. Four patients (0.3%) died within 24h of admission, 69 (5.7%) within 30 days...... and 198 (16.5%) within 365 days. On admission, 576 (48%) patients had a NEWS≥3 - of these 441 had a D-dimer≥0.50mgL(-1): 55 (12.5%) of these patients died within 30 days, compared with 5 (3.7%) of the 135 patients with a D-dimer

  9. Interference from heterophilic antibodies in D-dimer assessment. A case report.

    Science.gov (United States)

    Lippi, Giuseppe; Ippolito, Luigi; Tondelli, Maria Teresa; Favaloro, Emmanuel J

    2014-04-01

    We describe the case of a 3-year-old girl, admitted to the pediatric ward for three repeated episodes of severe migraine associated with vertigo, with onset 1 week after complete remission from an episode of chicken pox (i.e., varicella-zoster virus infection). All radiological and laboratory examinations were normal, except for a markedly elevated value of D-dimer (i.e. 8998 ng/ml; local reference range: < 243 ng/ml), measured with a commercial latex-enhanced immunoturbidimetric assay. After physical and Doppler ultrasound examination, possible presence of thrombosis was ruled out, and the patient was discharged. In the following year, however, her plasma D-dimer values always remained frankly elevated, so that an analytical interference was suspected. A plasma sample was treated with a specific heterophilic antibodies blocking reagent and then assayed along with the untreated sample, with these showing a marked discrepancy of D-dimer values, that is 232 versus 2877 ng/ml. These results, highly indicative for the presence of heterophilic antibodies, are discussed in the light of the serious challenges that this type of analytical interference may pose on quality and reliability of D-dimer testing. PMID:24253242

  10. Serum D-dimer concentrations in nephrotic syndrome track with albuminuria, not estimated glomerular filtration rate.

    LENUS (Irish Health Repository)

    Sexton, D J

    2012-01-01

    The nephrotic syndrome is associated with an increased risk of venous and arterial thrombosis. There are little published data on the distribution, interpretation or determinants of serum D-dimer levels in patients with the nephrotic syndrome. We aimed to describe this relationship.

  11. Concentration of D-dimers in healthy cats and sick cats with and without disseminated intravascular coagulation (DIC).

    Science.gov (United States)

    Tholen, Inger; Weingart, Christiane; Kohn, Barbara

    2009-10-01

    The objective of this prospective study was to measure concentrations of D-dimers in 48 cats with various diseases and in 20 healthy cats to evaluate the sensitivity and specificity for D-dimers to diagnose disseminated intravascular coagulation (DIC). The cats were classified as having DIC if an underlying disease and at least three of the following criteria were present: thrombocytopenia, prolonged activated partial thromboplastin time, prothrombin time or thrombin time, schistocytes and/or a reduced antithrombin activity. D-dimer concentrations were measured using a semi-quantitative latex agglutination (LA) test (Accuclot D-Dimer, Sigma Diagnostics). The D-dimer test was positive for 8/12 cats with DIC and for 16/36 sick cats without DIC. D-dimers were negative for all healthy control cats. The comparison of the sick cats with DIC and those without DIC revealed a specificity and sensitivity of the D-dimer test of 56% and 67%; a comparison of the results for healthy cats and cats with DIC revealed a specificity and sensitivity of 100% and 67%, respectively. The D-dimer LA test is only of limited value for the diagnosis of DIC in cats.

  12. Excluding venous thromboembolism using point of care D-dimer tests in outpatients: a diagnostic meta-analysis

    NARCIS (Netherlands)

    G.J. Geersing; K.J.M. Janssen; R. Oudega; L. Bax; A.W. Hoes; J.B. Reitsma; K.G.M. Moons

    2009-01-01

    Objective To review the evidence on the diagnostic accuracy of the currently available point of care D-dimer tests for excluding venous thromboembolism. Design Systematic review of research on the accuracy of point of care D-dimer tests, using bivariate regression to examine sources of variation and

  13. Evaluation of D-dimer and lactate dehydrogenase plasma levels in patients with relapsed acute leukemia

    Science.gov (United States)

    HU, WANGQIANG; WANG, XIAOXIA; YANG, RONGRONG

    2016-01-01

    Despite the outstanding advances made over the past decade regarding our knowledge of acute leukemia (AL), relapsed AL remains to be associated with a dismal prognosis. A better understanding of AL relapse and monitoring of the D-dimer and lactate dehydrogenase (LDH) plasma levels following chemotherapy may aid clinicians in determining whether relapse may occur in the subsequent phases of the disease. The present study evaluated D-dimer and LDH levels in 204 patients with relapsed AL. Data were collected at the initial onset of AL, at complete remission (CR) and in patients with relapsed AL. D-dimer plasma levels were significantly increased in patients with initial AL and in patients with relapsed AL (P=0.005 and P=0.007, respectively) but not in those with CR. LDH levels were significantly increased in AL patients at the initial onset of disease and at relapse compared with patients achieving CR, irrespective of cell type. Plasma prothrombin time, activated partial thromboplastin time and fibrinogen levels were not significantly different across patients (with the exception of acute promyelocytic leukemia patients) at the initial onset, relapsed AL or CR. Routine hematological parameters (white blood cell count, hemoglobin, platelet count) were significantly different at the initial onset of AL (P=0.002, P<0.001 and P=0.001, respectively) and during relapsed AL (P=0.009, P=0.003 and P<0.001, respectively) compared with patients achieving CR, suggesting an association between D-dimer, LDH and relapsed AL. These results also indicate that determination of D-dimer and LDH levels may be useful for predicting the probability of relapse during chemotherapy, but should also be combined with routine hematological parameters. PMID:27347185

  14. Kadar D-Dimer Plasma sebagai Prediktor Kematian Penderita Pneumonia Usia 2–59 Bulan

    Directory of Open Access Journals (Sweden)

    Retno Saraswati

    2012-03-01

    Full Text Available Intravascular and intraalveolar coagulation can be found in severe pneumonia as a response to local and systemic inflammation process in severe pneumonia. Clinical consequences of this coagulation changes is an increase of plasma D-dimer levels as a marker of coagulation and fibrinolyis activation, the number of organ dysfunction even death. The aim of this study was to understand the validity of high plasma D-dimer levels as a predictor of mortality in 2 to 59-month-old pneumonia patients. This was a prospective observational analytic study which was held in Dr. Hasan Sadikin Hospital Bandung. The subjects of this study were 2 to 59 months old children who were diagnosed as pneumonia and visited Pediatric Emergency Departement during October–November 2009. Plasma D-dimer assay was performed at admission and observed until the patient died or discharged from the hospital. Forty-five children were included in this study, 15 (33% died during observation. Plasma D-dimer level showed significant correlations (p=0.04 with the mortality in 2 to 59-month-old pneumonia patients with median and range of 0.60 mg/L (0.1–5.10 mg/L. Plasma D-dimer cut-off point of >0.4 mg/L gave 73.3% sensitivity (CI 95%, 44.9–92.0%, and 70.0% specificity (CI 95%, 50.6–85.2% with 71.1% accuracy for predicting mortality in 2 to 59-month-old pneumonia patients. In conclusions, there were significant correlations between elevated plasma Ddimer levels and mortality in 2 to 59-month-old patients with pneumonia.

  15. Validation of the Assay for D-dimer in Plasma by D-Dimer PLUS%D-Dimer PLUS测定血浆D-二聚体浓度性能评价

    Institute of Scientific and Technical Information of China (English)

    苏薇; 邱玲

    2008-01-01

    目的 验证D-Dimer PLUS测定血浆D-二聚体的各项性能参数.方法 参照美国临床实验室标准化委员会(NC-CLS)的相关文件,对D-Dimer PLUS在Sysmex CA7000型全自动血凝仪上测定血浆D-二聚体的性能进行全面的评价.结果 检测下限83.86μg/L;线性范围0~2 000 μg/L;回收率93%~113%;低值和高值批内不精密度(变异系数CV%)5.31%和2.67%,低值和高值总不精密度4.69%和4.14%;与mini-VIDAS(酶联免疫吸附实验)的测定结果 进行比对,相关系数r=0.915,平均百分偏差634.6%;内源性干扰物结合胆红素、乳糜微粒、溶血血红蛋白对D-二聚体测定结果 产生影响的浓度值分别为299 mg/L,882 FTU和7.8 g/L,游离胆红素和类风湿因子浓度达362 mg/L和540,000 IU/L时,D-二聚体测定结果 没有显著变化;验证参考值范围0~398 μg/L,高于厂家提供的参考值范围0~324μg/L,需重新建立参考值范围.结论 D-Dimer PLUS测定血浆D-二聚体浓度具有符合临床要求的精密度、准确度和灵敏度,可用于临床诊断实验.

  16. Age-adjusted cancer incidence rates by county and year, 1999-2009

    Data.gov (United States)

    California Environmental Health Tracking Program — This dataset contains age-adjusted incidence rates for 26 malignancy/age group/gender combinations for the years 1999-2009. These data are stratified by year and...

  17. 20 CFR 229.51 - Adjustment of age reduction.

    Science.gov (United States)

    2010-04-01

    ... for certain months before the employee or spouse attains retirement age, or the employee becomes... amount, effective the month in which the employee attains retirement age or becomes entitled to a DIB O/M... month in which the spouse attains retirement age: (1) Months in which the spouse O/M benefit...

  18. A neoantigenic determinant in the D-dimer fragment of fibrin

    NARCIS (Netherlands)

    Lugovskoy, E.V.; Kolesnikova, I.N.; Gritsenko, P.G.; Zolotareva, E.N.; Gaffney, P.; Nieuwenhuizen, W.; Komisarenko, S.V

    2002-01-01

    Monoclonal antibody (mAb) III-3b binds D-dimer with Kd = 1.4 × 10-10 M without cross-reaction with fibrin(ogen). The epitope for this mAb is in Bβ134-190, presumably in Bβ155-160. The latter site is buried in the coiled coil structure of fibrin(ogen) but it is exposed as a neoantigenic determinant i

  19. Validation of an immunochromatographic D-dimer test to presumptively identify menstrual fluid in forensic exhibits.

    Science.gov (United States)

    Holtkötter, Hannah; Dierig, Lisa; Schürenkamp, Marianne; Sibbing, Ulla; Pfeiffer, Heidi; Vennemann, Marielle

    2015-01-01

    Identifying the biological source of a crime scene stain can be crucial for police investigations in many scenarios. Blood is one of the most common fluids found, and accurate differentiation between peripheral blood and menstrual fluid could provide valuable information regarding the issue of consent in sexual assault cases. For the detection of menstrual fluid, no easy-to-use presumptive test is available to date. Therefore, this study aimed to validate a simple immunochromatographic test for the indication of menstrual fluid, focusing on a D-dimer assay. The Clearview® rapid D-dimer test provides a diagnostic assay for the detection of fibrin degradation products. We validated the sensitivity and robustness of the assay using fresh and dried menstrual fluid samples, body fluid mixtures, diluted samples, and casework swabs. Cross reactivity was tested for saliva, semen, vaginal fluid, and blood. No false positive results were obtained; it was possible to successfully analyze mixtures, highly diluted samples, and casework swabs. The results of this study indicate that the D-dimer assay reliably detects menstrual fluid in forensic exhibits and is easy to implement into the current workflow of body fluid identification.

  20. d-dimer testing as an adjunct to ultrasonography in patients with clinically suspected deep vein thrombosis: prospective cohort study

    Science.gov (United States)

    Bernardi, Enrico; Prandoni, Paolo; Lensing, Anthonie W A; Agnelli, Giancarlo; Guazzaloca, Giuliana; Scannapieco, Gianluigi; Piovella, Franco; Verlato, Fabio; Tomasi, Cristina; Moia, Marco; Scarano, Luigi; Girolami, Antonio

    1998-01-01

    Objective To investigate the efficacy of using a rapid plasma d-dimer test as an adjunct to compression ultrasound for diagnosing clinically suspected deep vein thrombosis. Design d-dimer concentrations were determined in all patients with a normal ultrasonogram at presentation. Repeat ultrasonography was performed 1 week later only in patients with abnormal d-dimer test results. Main outcome measure Patients with normal ultrasonograms were not treated with anticoagulants and were followed for 3 months for thromboembolic complications. Setting University research and affiliated centres. Subjects 946 patients with clinically suspected deep vein thrombosis. Results Ultrasonograms were abnormal at presentation in 260 (27.5%) patients. Of the remaining 686 patients tested for d-dimer, 88 (12.8%) had abnormal concentrations. During follow up venous thromboembolic complications occurred in one of the 598 patients who were not treated with anticoagulants and who had an initial normal ultrasonogram and d-dimer concentration, whereas thromboembolic complications occurred in two of the 83 untreated patients who had abnormal d-dimer concentrations but a normal repeat ultrasonogram. The cumulative incidence of venous thromboembolic complications during follow up was 0.4% (95% confidence interval 0% to 0.9%). The rapid plasma d-dimer test used as an adjunct to compression ultrasonography resulted in a reduction in the mean number of repeat ultrasound examinations and additional hospital visits from 0.7 to 0.1 per patient. Conclusions Testing for d-dimer as an adjunct to a normal baseline ultrasound examination decreased the number of subsequent ultrasound examinations considerably without any increased risk of venous thromboembolic complications in patients not receiving anticoagulants. The use of ultrasound and testing for d-dimer enabled treatment decisions to be made at the time of presentation in most patients. Key messagesPatients with clinically suspected deep vein

  1. D-Dimer Levels Predict Myocardial Injury in ST-Segment Elevation Myocardial Infarction: A Cardiac Magnetic Resonance Imaging Study

    Science.gov (United States)

    Song, Young Bin; Lima, Joao A. C.; Guallar, Eliseo; Choe, Yeon Hyeon; Hwang, Jin Kyung; Kim, Eun Kyoung; Yang, Jeong Hoon; Hahn, Joo-Yong; Choi, Seung-Hyuk; Lee, Sang-Chol; Lee, Sang Hoon; Gwon, Hyeon-Cheol

    2016-01-01

    Objectives Elevated D-dimer levels on admission predict prognosis in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI), but the association of D-dimer levels with structural markers of myocardial injury in these patients is unknown. Methods We performed cardiac magnetic resonance (CMR) imaging in 208 patients treated with primary PCI for STEMI. CMR was performed a median of 3 days after the index procedure. Of the 208 patients studied, 75 patients had D-dimer levels above the normal range on admission (>0.5 μg/mL; high D-dimer group) while 133 had normal levels (≤0.5 μg/mL; low D-dimer group). The primary outcome was myocardial infarct size assessed by CMR. Secondary outcomes included area at risk (AAR), microvascular obstruction (MVO) area, and myocardial salvage index (MSI). Results In CMR analysis, myocardial infarct size was larger in the high D-dimer group than in the low D-dimer group (22.3% [16.2–30.5] versus 18.8% [10.7–26.7]; p = 0.02). Compared to the low D-dimer group, the high D-dimer group also had a larger AAR (38.1% [31.7–46.9] versus 35.8% [24.2–45.3]; p = 0.04) and a smaller MSI (37.7 [28.2–46.9] versus 47.1 [33.2–57.0]; p = 0.01). In multivariate analysis, high D-dimer levels were significantly associated with larger myocardial infarct (OR 2.59; 95% CI 1.37–4.87; p<0.01) and lower MSI (OR 2.62; 95% CI 1.44–4.78; p<0.01). Conclusions In STEMI patients undergoing primary PCI, high D-dimer levels on admission were associated with a larger myocardial infarct size, a greater extent of AAR, and lower MSI, as assessed by CMR data. Elevated initial D-dimer level may be a marker of advanced myocardial injury in patients treated with primary PCI for STEMI. PMID:27513758

  2. Elevated D-dimers in attacks of hereditary angioedema are not associated with increased thrombotic risk

    Science.gov (United States)

    Reshef, A; Zanichelli, A; Longhurst, H; Relan, A; Hack, C E

    2015-01-01

    Background Recommended management of attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor (C1-INH) deficiency (C1-INH-HAE) includes therapy with exogenous C1INH. Thrombotic/thromboembolic events (TEE) have been reported with plasma-derived C1INH, but so far none with recombinant human C1INH (rhC1INH). This phase III, randomized, placebo (saline)-controlled study evaluated the safety of rhC1INH 50 IU/kg for the treatment of acute attacks in 74 patients with C1-INH-HAE. Methods Monitoring for TEE and assessment of risk of deep vein thrombosis (DVT) by the Wells prediction rule were performed, and levels of fibrin degradation products (plasma D-dimers) were assessed before study drug administration (baseline), 2 h, and 7 days posttreatment. Results Plasma D-dimer levels were elevated in 80% of the patients (median [25th–75th percentiles]: 2149 [480–5105] μg/l; normal ≤250 μg/l) and were higher in patients with submucosal (abdominal, oropharyngeal–laryngeal) attacks (3095 [890–10000] μg/l; n = 29) compared with subcutaneous (peripheral, facial) attacks (960 [450–4060] μg/l; n = 35). Median plasma D-dimer levels were comparable across treatment groups at baseline (1874 [475–4568] μg/l rhC1INH; 2259 [586–7533] μg/l saline) and 2 h postinfusion (2389 [760–4974] μg/l rhC1INH; 2550 [310–8410] μg/l saline); median plasma D-dimer levels were decreased by Day 7 in both groups (425 [232–3240] μg/l rhC1INH; 418 [246–2318] μg/l saline). No increased risk of DVT was identified, nor any TEE reported in rhC1INH treated or controls. Conclusion Elevated plasma D-dimer levels were associated with acute C1-INH-HAE attacks, particularly with submucosal involvement. However, rhC1INH therapy was not associated with thrombotic events. PMID:25640891

  3. Prognostic associations of preoperative plasma levels of fibrinogen and D-dimer after curative resection in patients with colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    王俊锋

    2013-01-01

    Objective To explore the associations of preoperative plasma levels of fibrinogen and D-dimer with clinico-pathologic parameters and overall survival in colorectal cancer patients after curative resection.Methods From

  4. Evaluation of the Diagnostic Accuracy of Serum D-Dimer Levels in Pregnant Women with Adnexal Torsion

    Directory of Open Access Journals (Sweden)

    Hasan Onur Topçu

    2015-01-01

    Full Text Available We aimed to evaluate the diagnostic accuracy of serum D-dimer levels in pregnant women with adnexal torsion (AT. The pregnant women with ovarian cysts who suffered from pelvic pain were divided into two groups; the first group consisted of the cases with surgically proven as AT (n = 17 and the second group consisted of the cases whose pain were resolved in the course of follow-up period without required surgery (n = 34. The clinical characteristics and serum D-dimer levels were compared between the groups. Patients with AT had a higher rate of elevated serum white blood cell (WBC count (57% vs. 16%, p = 0.04 and serum D-dimer levels (77% vs. 21%, p < 0.01 on admission in the study group than in the control group. Elevated D-dimer and cyst diameter larger than 5 cm yielded highest sensitivity (82% for each; whereas the presence of nausea and vomiting and elevated CRP had the highest specificity (85% and 88%, respectively. This is the first study that evaluates the serum D-dimer levels in humans in the diagnosis of AT, and our findings supported the use of D-dimer for the early diagnosis of AT in pregnant women.

  5. D-Dimer and Carcinoembryonic Antigen Levels: Useful Indicators for Predicting the Tumor Stage and Postoperative Survival.

    Science.gov (United States)

    Tekeşin, Kemal; Bayrak, Savaş; Esatoğlu, Varol; Özdemir, Ebru; Özel, Leyla; Melih Kara, Veli

    2016-01-01

    The purpose of this prospective study is to determine the preoperative plasma D-dimer and serum Carcinoembryonic Antigen (CEA) levels of patients scheduled for curative surgical resection for colorectal cancer and to evaluate the significance of these levels on the prognosis and postoperative survival rate. One hundred sixty-five patients with colorectal cancer, who were scheduled to have elective resection between January 2008 and January 2011, were included in the study. A significant increase was observed in the D-dimer levels, particularly in poorly differentiated tumors. The distance covered by the tumor inside the walls of the colon and rectum (T-stage) was significant for both D-dimer and CEA levels. As the T-stage increased, there was also a significant increase in the D-dimer and CEA levels. A high significance and correlation level was detected between the TNM staging and both D-dimer and CEA. A significant relationship was found between the advanced tumor stage and short postoperative survival rate of patients with colorectal cancer. Therefore, the analysis of preoperative D-dimer and CEA levels can be useful in predicting the stage and differentiation of the tumor and the postoperative survival rate. PMID:27651789

  6. Behavioral Risk Factor Surveillance System (BRFSS) Age-Adjusted Prevalence Data (2011 to present)

    Data.gov (United States)

    U.S. Department of Health & Human Services — 2011 to present. BRFSS combined land line and cell phone age-adjusted prevalence data. The BRFSS is a continuous, state-based surveillance system that collects...

  7. Impact of D-Dimer for Prediction of Incident Occult Cancer in Patients with Unprovoked Venous Thromboembolism

    Science.gov (United States)

    Han, Donghee; ó Hartaigh, Bríain; Lee, Ji Hyun; Cho, In-Jeong; Shim, Chi Young; Chang, Hyuk-Jae; Hong, Geu-Ru; Ha, Jong-Won; Chung, Namsik

    2016-01-01

    Background Unprovoked venous thromboembolism (VTE) is related to a higher incidence of occult cancer. D-dimer is clinically used for screening VTE, and has often been shown to be present in patients with malignancy. We explored the predictive value of D-dimer for detecting occult cancer in patients with unprovoked VTE. Methods We retrospectively examined data from 824 patients diagnosed with deep vein thrombosis or pulmonary thromboembolism. Of these, 169 (20.5%) patients diagnosed with unprovoked VTE were selected to participate in this study. D-dimer was categorized into three groups as: 4,000 ng/ml. Cox regression analysis was employed to estimate the odds of occult cancer and metastatic state of cancer according to D-dimer categories. Results During a median 5.3 (interquartile range: 3.4–6.7) years of follow-up, 24 (14%) patients with unprovoked VTE were diagnosed with cancer. Of these patients, 16 (67%) were identified as having been diagnosed with metastatic cancer. Log transformed D-dimer levels were significantly higher in those with occult cancer as compared with patients without diagnosis of occult cancer (3.5±0.5 vs. 3.2±0.5, P-value = 0.009, respectively). D-dimer levels >4,000 ng/ml was independently associated with occult cancer (HR: 4.12, 95% CI: 1.54–11.04, P-value = 0.005) when compared with D-dimer levels 4000 ng/ml were also associated with a higher likelihood of metastatic cancer (HR: 9.55, 95% CI: 2.46–37.17, P-value 4000 ng/ml are independently associated with the likelihood of occult cancer among patients with unprovoked VTE. PMID:27073982

  8. Adjustment to Aging, Subjective Age and Age Representation: Assessing a Nationally-Diverse Population of Older Adults

    Directory of Open Access Journals (Sweden)

    Sofia von Humboldt

    2012-11-01

    Full Text Available Aim: This research sought to analyse older adults’ conceptualization of adjustment to aging (AtA, subjective age (SA and age representation (AR, adding a cross-national comparative perspective to aging well. Method: Questionnaires were completed, assessing participants’ background information. Semi-structured interviews were performed, addressing three core areas: SA, AtA and AR. Complete information on 231 older adults aged between 74-102 years (M = 83.1; SD = 6.692 from four different nationalities, was available. Data was subjected to content analysis. Results: Seven categories were identified to contribute to AtA: ‘accomplishment, personal fulfilment and future projects’, ‘occupation, profession, autonomy and leisure’, ‘health status, physical and intellectual functioning’, ‘valorisation of time and age’, ‘family, social and interpersonal attachment’, ‘stability, quality and financial situation’, and ‘sense of limit and existential issues’. Five categories were identified for SA: ‘with congruence’, ‘without concern’, ‘with apprehension’, ‘young-at-heart’ and ‘good enough’. For AR, eight emergent categories were found: ‘future investment’, ‘reconciliation with life’, ‘present challenge’, ‘regret about the past’, ‘dynamic life’, ‘with contentment’, ‘as an opportunity’ and ‘with dissatisfaction’. Conclusion: This research contributes for a better understanding of what defines AtA, SA and AR in older adults. Moreover, interventions and communication approaches in clinical practice and program development in health care context should focus on shared perceptions of aging well.

  9. DIAGNOSTIC VALUE OF D-DIMER MEASUREMENT IN PATIENTS SUSPECTED TO HAVE CEREBRAL VENOUS THROMBOSIS

    Directory of Open Access Journals (Sweden)

    M Ghaffarpour

    2008-12-01

    Full Text Available "nAmong the causes of headache, cerebral venous and/or dural sinus thrombosis (CVT is an important challenge because of its variable clinical presentation, having negative brain CT in up to 30% of cases and unavailability of MRI in some situations. On the other hand as D-Dimer (DD test has been reported to be a sensitive test for the exclusion of venous thromboembolism, we sought whether it could be useful in the diagnosis of cerebral venous thrombosis. A prospective study of 104 consecutive patients with headache or unusual ischemic stroke (infarction in brain CT, but not compatible with any brunch of cerebral arteries, suggesting CVT was conducted between 2003 and 2005. D-Dimer test determined for all patients in the emergency ward before MRI or MRV was performed. Titers above 500 ng/ml were regarded as positive test. From a total 104 patients, 21 cases (20.2% were confirmed (by MRI and/or MRV to have CVT, 20/21 (95.7% of whom had positive DD test. In the remainder 83 (without CVT it was only positive in 16.8% (14/83, which was statistically meaningful (P < 0.001. Specificity, sensitivity, negative and positive predictive values of DD test were 83.1, 95.2, 98.6 and 58.8%, respectively, so application of this test would be useful in the diagnosis of CVT and values below 500 ng/ml make acute thrombosis unlikely.

  10. Complementarity of lung scintigraphy and D-dimer test in pulmonary embolism

    International Nuclear Information System (INIS)

    D-dimer assay (DDA), measuring fibrin degradation products, was compared with lung scintigraphy (LS) in a prospective unselected series of 83 consecutive patients referred owing to suspicion of pulmonary embolism (PE). This patient series was also used to compare several methods of performing and interpreting LS images. The final diagnosis was established independently by a separate panel with all available information except for the result of DDA. D-dimer was determined by ELISA (threshold value 500 ng/ml). LS, including perfusion (.Q) and pseudo-ventilation (Technegas) (.V), was classified according to PIOPED, (1) immediately by the physician on duty, and (2) retrospectively by a blinded panel. A positive (19) or negative (61) diagnosis of PE was achieved in 80 patients, the prevalence of PE being 24%. Only one false-negative was noted on DDA (sensitivity=95%) but there were 42 false-positives (specificity=31%), resulting in a positive predictive value of 30% and a negative predictive value of 95%. Emergency and retrospective interpretations of LS were close (kappa=0.4). In a minority of patients, PE may be excluded with reasonable certainty if DDA is normal, resulting in a significant saving in terms of time and money. (orig.). With 3 tabs

  11. The diagnostic value of ventilation-perfusion scintigraphy combined with plasma D-dimer assay in diagnosis of pulmonary embolism

    International Nuclear Information System (INIS)

    Objective: To investigate the clinical diagnostic value of ventilation-perfusion scintigraphy combined with plasma D-dimer assay in diagnosis of pulmonary embolism (PE). Methods: One hundred and four patients with clinically suspected PE underwent both pulmonary ventilation-perfusion scintigraphy and plasma D-dimer assay. According to the criteria of prospective investigation of the pulmonary embolism diagnosis (PIOPED), ventilation-perfusion scintigraphy was interpreted as normal, very low or low probability of PE, intermediate probability of PE and high probability of PE. High probability was considered as positive; normal and very low or low probability as negative and intermediate probability as non-diagnostic. Plasma D-dimer levels were measured using a quantitative immunoturbidimetric method, and a cut-off value of 500 mg/L was used in the diagnosis of PE. Clinical diagnostic value of ventilation-perfusion scintigraphy, D-dimer assay and combined use of ventilation-perfusion scintigraphy and D-dimer assay for diagnosing PE was evaluated, respectively, comparing with the final clinical diagnosis that was based on the clinical findings. Results: Among the 104 patients, 44 were diagnosed with PE and 60 were excluded. Ventilation-perfusion scintigraphy provided diagnostic interpretations for 86 (82.7%) patients, and non-diagnostic interpretations for 18 (17.3%) patients. For diagnosing PE, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of ventilation-perfusion scintigraphy was 84.1%, 75.0%, 78.8%, 71.2% and 86.5%, respectively, and with D-dimer assay was 93.2%, 60.0%, 74.0%, 63.1% and 92.3%, respectively. If a plasma D-dimer level of < 500 mg/L was taken as a criterion to exclude PE for those intermediate probability of ventilation-perfusion scintigraphy, the diagnostic specificity and accuracy would be raised to 85.0% and 84.6%, respectively. Conclusions: When a non-diagnostic interpretation was occurred on

  12. Embolic Stroke Diagnosed by Elevated D-Dimer in a Patient With Negative TEE for Cardioembolic Source

    Directory of Open Access Journals (Sweden)

    Irina Y. Sazonova PhD

    2014-12-01

    Full Text Available We report a case of cerebrovascular accident with thromboembolic stroke etiology in a patient who had atrial flutter and negative transesophageal echocardiography (TEE results. The increased D-dimer levels (1877 ng/mL initiated referral for magnetic resonance imaging and magnetic resonance angiography of the brain that showed classic recanalization of an embolic thrombus in the angular branch of the left middle cerebral distribution. The D-dimer level of this patient was normalized after 3 months of anticoagulation therapy. Although TEE is considered the gold standard for evaluation of cardiac source of embolism, exclusion of intracardiac thrombus with TEE alone does not eliminate the risk of thromboembolic events. This case highlights the utility of D-dimer as a potential adjunct in the decision-making process to guide investigation of thromboembolism, determine subsequent therapy, and hence reduce the risk of embolic stroke recurrence.

  13. Large D-Dimer Fluctuation in Normal Pregnancy: A Longitudinal Cohort Study of 4,117 Samples from 714 Healthy Danish Women

    OpenAIRE

    Hedengran, Katrine K.; Malene R Andersen; Steen Stender; Pal B. Szecsi

    2016-01-01

    Introduction. D-dimer levels increase throughout pregnancy, hampering the usefulness of the conventional threshold for dismissing thromboembolism. This study investigates the biological fluctuation of D-dimer in normal pregnancy. Methods. A total of 801 healthy women with expected normal pregnancies were recruited. D-dimer was repeatedly measured during pregnancy, at active labor, and on the first and second postpartum days. Percentiles for each gestational week were calculated. Each individu...

  14. High Pretreatment D-Dimer Levels Correlate with Adverse Clinical Features and Predict Poor Survival in Patients with Natural Killer/T-Cell Lymphoma

    OpenAIRE

    Bi, Xi-wen; Wang, Liang; Zhang, Wen-Wen; Sun, Peng; Yan, Shu-Mei; Liu, Pan-pan; Li, Zhi-Ming; Jiang, Wen-qi

    2016-01-01

    Pretreatment plasma D-dimer levels have been reported to predict survival in several types of malignancies. The aim of this study was to evaluate the prognostic value of D-dimer levels in patients with newly diagnosed natural killer/T-cell lymphoma (NKTCL). The cut-off value of D-dimer to predict survival was set as 1.2 μg/mL based on the receiver operating curve analysis. Patients with a D-dimer level ≥ 1.2 μg/mL had significantly more adverse clinical features, including poor performance st...

  15. The value of blood D-dimer test in the diagnosis of walk-in patients with venous thromboembolism

    Directory of Open Access Journals (Sweden)

    Shozo Yasuoka

    2011-03-01

    Full Text Available Shozo Yasuoka, Shunichiro KubotaYasuoka Clinic, Musashino City, Tokyo, JapanAbstract: Venous thromboembolism (VTE and related pulmonary thromboembolism are life-threatening diseases that require efficient diagnosis and clinical management. While the diagnosis and treatment of VTE in hospitalized patients has been extensively studied, less has been reported on walk-in patients with VTE. Here we report on four outpatients with VTE that were efficiently diagnosed using the blood D-dimer test and successfully treated.Keywords: venous thromboembolism, pulmonary thromboembolism, blood D-dimer test

  16. Ratchet rotation of a 3D dimer on a vibrating plate.

    Science.gov (United States)

    Wang, Jiao; Liu, Caishan; Jia, Yan-Bin; Ma, Daolin

    2014-01-01

    This work studies the dynamics of a 3D dimer bouncing upon a horizontal plate undergoing a vertical harmonic vibration. Despite complex interactions within the system due to impacts and friction, numerical simulation shows that, under certain conditions prescribed for the dynamics, the center of mass of the dimer, when projected onto a horizontal plane, will follow a circular orbit. The phenomenon is like a particle under Coulomb friction performing a ratchet motion that rotates around. Investigations further reveal that the dimer dynamics bear some typical characteristics of a nonlinear system, including sensitivity to the initial conditions and bifurcation behaviors related to the physical parameters of the dynamics. Our results indicate that the coefficient of restitution and the plate's vibration intensity play critical roles in exciting the circular orbit, while the dimer's geometry and the vibration frequency mainly influence the trajectory characteristics. These findings may help understand transport mechanisms underlying systems of granular matter with anisotropic particles. PMID:24458553

  17. Clinical significance of plasma D-dimer and von Willebrand factor levels in patients with ulcer colitis

    Institute of Scientific and Technical Information of China (English)

    Gang Xu; Ke-Li Tian; Guo-Ping Liu; Xue-Jun Zhong; Shao-Ling Tang; Yan-Ping Sun

    2002-01-01

    AIM: To investigate the levels of D-dimer(DD) and vonWillebrand factor(vWF) and the relationship between DDand vWF in ulcerative colitis(UC) patients.METHODS: A total of 29 plasma specimens were obtainedfrom patients with ulcerative colitis (male 13, female 16),aged 21-47 years (33 + 11). Disease activity was assessed byTruelove-Writeria. Patients with a score of above 5 wereregarded as having active colitis. Twenty healthy people(male 12, female 8),aged 19-53 years(31 + 14), ssrved asnormal controls. Blood samples were taken from anantecubital vein puncture. Blood(1.8 mL) was injected intothe tubes containing sodium citrate (0. 13 mmol/L). Theplasma was obtained by centrifugation at 3000 r@ min-1 for 10min, and stored at -80 ℃ until assayed by ELISA.RESULTS: The mean plasma levels of DD and vWF in activeUC patients were significantly higher than those of thecontrols(0.69+0.41 vs0.27+0.11, P<0.01;143+46 vs103 + 35, P < 0.01 ). The mean plasma levels of DD in thepatients with active disease were higher than those withinactive disease(0. 69 + 0. 41 vs 0.48+0.29, P<0.05). Thelevls of v WF were not different between active and inactivepatients. DD levels were positively related to vWF levels( r =0.574, P < 0. 01 ). There was no significant differencebetween levels of DD and vWF and the scope of disease cndsex of the patients.CONCLUSION: vWF is an important feature and a goodmarker of UC; intravascular thrombus and endothelial celldysfunction were found in UC patients; and the combinedtest of DD and vWF is helpful to distinguish the activity ofthe UC patients.

  18. Effects of aging and dual tasking on step adjustments to perturbations in visually cued walking.

    Science.gov (United States)

    Mazaheri, Masood; Hoogkamer, Wouter; Potocanac, Zrinka; Verschueren, Sabine; Roerdink, Melvyn; Beek, Peter J; Peper, C E; Duysens, Jacques

    2015-12-01

    Making step adjustments is an essential component of walking. However, the ability to make step adjustments may be compromised when the walker's attentional capacity is limited. This study compared the effects of aging and dual tasking on step adjustments in response to stepping-target perturbations during visually cued treadmill walking. Fifteen older adults (69.4 ± 5.0 years; mean ± SD) and fifteen young adults (25.4 ± 3.0 years) walked at a speed of 3 km/h on a treadmill. Both groups performed visually cued step adjustments in response to unpredictable shifts of projected stepping targets in forward (FW), backward (BW) or sideward (SW) directions, at different levels of task difficulty [which increased as the available response distance (ARD) decreased], and with and without dual tasking (auditory Stroop task). In both groups, step adjustments were smaller than required. For FW and BW shifts, older adults undershot more under dual-task conditions. For these shifts, ARD affected the age groups differentially. For SW shifts, larger errors were found for older adults, dual tasking and the most difficult ARD. Stroop task performance did not differ between groups in all conditions. Older adults have more difficulty than young adults to make corrective step adjustments while walking, especially under dual-tasking conditions. Furthermore, they seemed to prioritize the cognitive task over the step adjustment task, a strategy that may pose aging populations at a greater fall risk. For comparable task difficulty, the older adults performed considerably worse than the young adults, indicating a decreased ability to adjust steps under time pressure.

  19. Effects of aging and dual tasking on step adjustments to perturbations in visually cued walking.

    Science.gov (United States)

    Mazaheri, Masood; Hoogkamer, Wouter; Potocanac, Zrinka; Verschueren, Sabine; Roerdink, Melvyn; Beek, Peter J; Peper, C E; Duysens, Jacques

    2015-12-01

    Making step adjustments is an essential component of walking. However, the ability to make step adjustments may be compromised when the walker's attentional capacity is limited. This study compared the effects of aging and dual tasking on step adjustments in response to stepping-target perturbations during visually cued treadmill walking. Fifteen older adults (69.4 ± 5.0 years; mean ± SD) and fifteen young adults (25.4 ± 3.0 years) walked at a speed of 3 km/h on a treadmill. Both groups performed visually cued step adjustments in response to unpredictable shifts of projected stepping targets in forward (FW), backward (BW) or sideward (SW) directions, at different levels of task difficulty [which increased as the available response distance (ARD) decreased], and with and without dual tasking (auditory Stroop task). In both groups, step adjustments were smaller than required. For FW and BW shifts, older adults undershot more under dual-task conditions. For these shifts, ARD affected the age groups differentially. For SW shifts, larger errors were found for older adults, dual tasking and the most difficult ARD. Stroop task performance did not differ between groups in all conditions. Older adults have more difficulty than young adults to make corrective step adjustments while walking, especially under dual-tasking conditions. Furthermore, they seemed to prioritize the cognitive task over the step adjustment task, a strategy that may pose aging populations at a greater fall risk. For comparable task difficulty, the older adults performed considerably worse than the young adults, indicating a decreased ability to adjust steps under time pressure. PMID:26298043

  20. Lithium-ion Open Circuit Voltage (OCV) curve modelling and its ageing adjustment

    Science.gov (United States)

    Lavigne, L.; Sabatier, J.; Francisco, J. Mbala; Guillemard, F.; Noury, A.

    2016-08-01

    This paper is a contribution to lithium-ion batteries modelling taking into account aging effects. It first analyses the impact of aging on electrode stoichiometry and then on lithium-ion cell Open Circuit Voltage (OCV) curve. Through some hypotheses and an appropriate definition of the cell state of charge, it shows that each electrode equilibrium potential, but also the whole cell equilibrium potential can be modelled by a polynomial that requires only one adjustment parameter during aging. An adjustment algorithm, based on the idea that for two fixed OCVs, the state of charge between these two equilibrium states is unique for a given aging level, is then proposed. Its efficiency is evaluated on a battery pack constituted of four cells.

  1. Age affects the adjustment of cognitive control after a conflict: evidence from the bivalency effect

    OpenAIRE

    Rey-Mermet, Alodie; Meier, Beat

    2015-01-01

    Age affects cognitive control. When facing a conflict, older adults are less able to activate goal-relevant information and inhibit irrelevant information. However, cognitive control also affects the events after a conflict. The purpose of this study was to determine whether age affects the adjustment of cognitive control following a conflict. To this end, we investigated the bivalency effect, that is, the performance slowing occurring after the conflict induced by bivalent stimuli (i.e., sti...

  2. Improving adjustments for older age in pre-hospital assessment and care

    OpenAIRE

    Rehn Marius

    2013-01-01

    Abstract Population estimates projects a significant increase in the geriatric population making elderly trauma patients more common. The geriatric trauma patients experience higher incidence of pre-existing medical conditions, impaired age-dependent physiologic reserve, use potent drugs and suffer from trauma system related shortcomings that influence outcomes. To improve adjustments for older age in pre-hospital assessment and care, several initiatives should be implemented. Decision-makers...

  3. Raised D-dimer levels in acute sickle cell crisis and their correlation with chest X-ray abnormalities

    Directory of Open Access Journals (Sweden)

    Hassan, Imad S. A.

    2010-01-01

    Full Text Available Objective: Quantitation of D-dimer level during a sickling crisis and its correlation with other clinical abnormalities. Design: Prospective longitudinal study. Setting: Armed Forces Hospital, Southern Region, Kingdom of Saudi Arabia. Patients: Adult patients (12 years and older admitted acutely with a sickle cell crisis who consent to taking part in the study. Candidates may re-participate if they are readmitted with a further acute painful crisis. Results: 36 patients with homozygous sickle cell disease consented to take part in the study. D-dimer levels were raised in 31 (68.9% of 45 episodes of painful crisis of whom 13 had an abnormal chest X-ray. Of those with a normal chest X-ray only one patient had a raised D-dimer level: sensitivity of 92.3%, specificity 40.6%, positive predictive value 38.7% and negative predictive value of 92.9% for an abnormal chest X-ray. Conclusion: D-dimer levels are frequently raised during an acute painful crisis. A normal level has a high negative predictive value for an abnormal chest X-ray.

  4. Normal D-dimer ved dyb venøs trombose i en overekstremitet hos to patienter med pacemaker

    DEFF Research Database (Denmark)

    Byrne, Christina; Abdulla, Jawdat; Christensen, Jan Kim

    2015-01-01

    Danish guidelines recommend the use of D-dimer to exclude deep venous thrombosis (DVT) in the lower extremities. However, guidelines are lacking for DVT in the upper extremities. We describe two young women with transvenous pacemaker electrodes and symptomatic DVT in related veins. Despite a normal...

  5. Normal D-dimer ved dyb venøs trombose i en overekstremitet hos to patienter med pacemaker

    DEFF Research Database (Denmark)

    Byrne, Christina; Abdulla, Jawdat; Christensen, Jan Kim

    2015-01-01

    Danish guidelines recommend the use of D-dimer to exclude deep venous thrombosis (DVT) in the lower extremities. However, guidelines are lacking for DVT in the upper extremities. We describe two young women with transvenous pacemaker electrodes and symptomatic DVT in related veins. Despite a norm...

  6. Age-Adjustment and Related Epidemiology Rates in Education and Research

    Science.gov (United States)

    Baker, John D.; Kruckman, Laurence; George, Joyce

    2006-01-01

    A quick review of introductory textbooks reveals that while gerontology authors and instructors introduce some aspect of demography and epidemiology data, there is limited focus on age adjustment or other important epidemiology rates. The goal of this paper is to reintroduce a variety of basic epidemiology strategies such as incidence, prevalence,…

  7. D-dimer levels in assessing severity and clinical outcome in patients with community-acquired pneumonia. A secondary analysis of a randomised clinical trial

    NARCIS (Netherlands)

    Snijders, Dominic; Schoorl, Margreet; Schoorl, Marianne; Bartels, Piet C.; van der Werf, Tjip S.; Boersma, Wim G.

    2012-01-01

    Background: D-dimer levels are in several studies elevated in patients with CAP. In this study we assess the use of D-dimer levels and its association with severity assessment and clinical outcome in patients hospitalised with community-acquired pneumonia. Methods: In a subset of randomised trial pa

  8. The value of D-dimer in the detection of early deep-vein thrombosis after total knee arthroplasty in Asian patients: a cohort study

    Directory of Open Access Journals (Sweden)

    Huang Chung-Cheng

    2008-05-01

    Full Text Available Abstract Background and purpose The relationship of D-dimer and deep-vein thrombosis (DVT after total knee arthroplasty (TKA remains controversial. The purpose of this study was to assess the value of D-dimer in the detection of early DVT after TKA. Methods The measurements of plasma D-dimer level were obtained preoperatively and at day 7 postoperatively in 78 patients undergoing TKA. Ascending venography was performed in 7 to 10 days after surgery. The plasma D-dimer levels were correlated statistically with the venographic DVT. Results Venographic DVT was identified in 40% of patients. High plasma D-dimer level >2.0 μg/ml was found in 68% of patients with DVT and 45% without DVT (P Conclusion High plasma D-dimer level is a moderately sensitive, but less specific marker in the detection of early of DVT after TKA. Measurement of serum D-dimer alone is not accurate enough to detect DVT after TKA. Venography is recommended in patients with elevated D-dimer and clinically suspected but asymptomatic DVT after TKA.

  9. Plasma level of D-dimer accompanying different types of gynecologic surgery and effects of prophylactic subcutaneous injection of heparin calcium

    Directory of Open Access Journals (Sweden)

    Sakika Yanai

    2015-06-01

    Conclusions: Plasma levels of D-dimer on POD-1 were higher than those on the DPE in each type of gynecologic surgery. The D-dimer level remained high even on POD-6, and not changed by prophylactic subcutaneous injection of heparin calcium. [Int J Reprod Contracept Obstet Gynecol 2015; 4(3.000: 551-554

  10. Evaluation of Serum Pregnancy Associated Plasma Protein-A & Plasma D-Dimer in Acute Coronary Syndrome

    Science.gov (United States)

    Thomas, Vivian Samuel

    2016-01-01

    Introduction Acute coronary syndrome (ACS), a spectrum comprising unstable angina pectoris, ST Elevated Myocardial Infarction (STEMI) & Non ST Elevated Myocardial Infarction (NSTEMI) is the major cause of presentation in Emergency Department today. Though ECG and cardiac enzymes are used for diagnosis, they mislead the diagnosis sometimes and delay in treatment initiation. This leads us to search certain new parameters which reflect the pathophysiology of ACS. Markers of plaque stability like Pregnancy Associated Plasma Protein-A and D-Dimer, a marker of ongoing thrombosis are found to be better markers in early diagnosis. Aim To evaluate the diagnostic competence of PAPP-A and D-Dimer in acute coronary syndrome over CK-MB and to compare with the inflammatory marker High Sensitive C-Reactive Protein (hs-CRP) which is associated with atherosclerosis. Materials and Methods Fifty patients presenting with acute onset of chest pain to Emergency Department with or without ECG changes served as cases and 50 healthy people served as controls. Serum PAPP-A is measured by Enzyme Linked Immunosorbent Assay (ELISA), D-Dimer and hs-CRP by using Latex Turbidimetry method. Results A statistical significant difference of PAPP-A and D-Dimer was noted between the ACS and controls (p < 0.001) whereas CK-MB shows no much difference (p 0.09). Statistically significant positive correlation is noted between parameters. Conclusion PAPP-A marker of plaque instability and D-Dimer marker of ongoing thrombosis are raised in acute coronary syndrome and thus can be considered as one of the marker in ACS for diagnosis. PMID:26894054

  11. In the eyes of older adults: Self-reported age and adjustment in African and European older adults

    Directory of Open Access Journals (Sweden)

    Sofia von Humbold

    2013-09-01

    Full Text Available To explore older adults’ perceptions of subjective age and adjustment to ageing and to analyse the correlational structure of the pre-categories in our study: subjective age, indicators of adjustment to ageing and of personal age perception. An exploratory, descriptive mixed-methods design was utilised. A purposive sampling method was used to select 154 older adults aged between 75 and 99 years from three different nationalities. Semi-structured interviews were performed, addressing two core areas: subjective age and adjustment to ageing. Data was subjected to content analysis. Representation of the correlational structure of the precategories in our study (subjective age and indicators of adjustment to ageing were analysed by a Multiple Correspondence Analysis. Standardised instruments measured regular cognitive abilities. Five categories derived from interviews for subjective age: ‘adapted’, ‘disconnected’, ‘old’, ‘youthful’ and ‘tolerant’. A total of seven categories emerged as indicators of adjustment to ageing: ‘social networking’, ‘health’, ‘time perspective’, ‘spirituality’, ‘financial autonomy’, ‘professional activities’ and ‘fulfilment and leisure’. These results supported a model for each pre-category. Subjective age was explained by a two-factor model: ‘age-conscientious’ and ‘youthful’. A three-dimensional model formed by ‘reconciled’, ‘satisficers’ and ‘maximisers’ was indicated as a best-fit solution for adjustment to ageing. A three-dimensional overall model for PAP was formed by ‘age-cognisant’, ‘fulfilled’ and ‘satisficers’. The findings highlighted the underdeveloped potential of subjective age, adjustment to ageing and a personal age perception overall model for this population. Enhancing subjective age and adjustment to ageing might be an important target to improve older adults’ interventions’ outcomes.

  12. Relative age effects in athletic sprinting and corrective adjustments as a solution for their removal.

    Directory of Open Access Journals (Sweden)

    Michael Romann

    Full Text Available Relative Age Effects (RAEs refer to the selection and performance differentials between children and youth who are categorized in annual-age groups. In the context of Swiss 60m athletic sprinting, 7761 male athletes aged 8 - 15 years were analysed, with this study examining whether: (i RAE prevalence changed across annual age groups and according to performance level (i.e., all athletes, Top 50%, 25% & 10%; (ii whether the relationship between relative age and performance could be quantified, and corrective adjustments applied to test if RAEs could be removed. Part one identified that when all athletes were included, typical RAEs were evident, with smaller comparative effect sizes, and progressively reduced with older age groups. However, RAE effect sizes increased linearly according to performance level (i.e., all athletes - Top 10% regardless of age group. In part two, all athletes born in each quartile, and within each annual age group, were entered into linear regression analyses. Results identified that an almost one year relative age difference resulted in mean expected performance differences of 10.1% at age 8, 8.4% at 9, 6.8% at 10, 6.4% at 11, 6.0% at 12, 6.3% at 13, 6.7% at 14, and 5.3% at 15. Correction adjustments were then calculated according to day, month, quarter, and year, and used to demonstrate that RAEs can be effectively removed from all performance levels, and from Swiss junior sprinting more broadly. Such procedures could hold significant implications for sport participation as well as for performance assessment, evaluation, and selection during athlete development.

  13. Increased tissue factor, MMP-8, and D-dimer expression in diabetic patients with unstable advanced carotid atherosclerosis

    Directory of Open Access Journals (Sweden)

    Jerzy Krupinski

    2007-09-01

    Full Text Available Jerzy Krupinski1,2, Marta M Turu1,2, M Angels Font1, Nesser Ahmed3, Matthew Sullivan3, Ana Luque1,2, Francisco Rubio1, Lina Badimon2, Mark Slevin31Department of Neurology, Stroke Unit, University Hospital of Bellvitge (HUB, Fundacio IDIBELL, Barcelona, Spain; 2Cardiovascular Research Centre, IIBB/CSIC-HSCSP-UAB, Barcelona, Spain; 3School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, United KingdomAbstract: Advanced atherogenesis is characterized by the presence of markers of enhanced prothrombotic capacity, attenuated fibrinolysis, and by clinical conditions associated with defective coagulation. Diabetes may be associated with enhanced lesion instability and atherosclerotic plaque rupture. Plaques obtained from 206 patients undergoing carotid endarterectomy were divided into diabetic (type 2 and nondiabetic and analyzed by Western blotting and immunohistochemistry to detect tissue factor (TF, metalloproteinases (MMP-2, -8, -9, and fibrin/fibrinogen related antigens, and in situ zymography to detect MMP activity. Plasma samples were quantified for TF procoagulant activity, C-reactive protein, fibrinogen and D-dimer. Diabetic and symptomatic patients with hypoechogenic plaques had increased plasma TF activity and D-dimer, compared with those with hyperechogenic plaques (p = 0.03, p = 0.007, respectively. Diabetic, symptomatic patients had higher plasma D-dimer levels than asymptomatic patients (p = 0.03. There was a significant correlation between intramural TF levels and D-dimer in diabetic patients with symptomatic disease (p = 0.001, r2 = 0.4. In diabetic patients, plasma fibrinogen levels were higher in patients with hypoechogenic plaques (p = 0.007. Diabetic patients with ulcerated plaques had higher plasma D-dimer and MMP-8 levels than those with fibrous plaques (p = 0.02, p = 0.01, respectively. This data suggests that currently available circulating markers may be clinically useful to select

  14. Improving adjustments for older age in pre-hospital assessment and care

    Directory of Open Access Journals (Sweden)

    Rehn Marius

    2013-01-01

    Full Text Available Abstract Population estimates projects a significant increase in the geriatric population making elderly trauma patients more common. The geriatric trauma patients experience higher incidence of pre-existing medical conditions, impaired age-dependent physiologic reserve, use potent drugs and suffer from trauma system related shortcomings that influence outcomes. To improve adjustments for older age in pre-hospital assessment and care, several initiatives should be implemented. Decision-makers should make system revisions and introduce advanced point-of-care initiatives to improve outcome after trauma for the elderly.

  15. Serum Potassium Levels Inversely Correlate with D-Dimer In Patients with Acute-Onset Atrial Fibrillation.

    Science.gov (United States)

    Cervellin, Gianfranco; Bonfanti, Laura; Picanza, Alessandra; Lippi, Giuseppe

    2014-12-01

    Background: D-dimer values are frequently increased in patients with atrial fibrillation (AF) compared to subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. Objective: D-dimer values are frequently increased in patients with atrial fibrillation (AF) compared with subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. The aim of this study was to investigate correlations between D-dimer and serum potassium in acute-onset AF (AAF). Methods: To investigate the potential correlation between the values of serum potassium and D-dimer in patients with AAF, we retrospectively reviewed clinical and laboratory data of all emergency department visits for AAF in 2013. Results: Among 271 consecutive AAF patients with D-dimer assessments, those with hypokalemia (n = 98) had significantly higher D-dimer values than normokalemic patients (139 versus 114 ng/mL, p = 0.004). The rate of patients with D-dimer values exceeding the diagnostic cut-off was higher in the group of patients with hypokalemia than in those with normal serum potassium (26.5% versus 16.2%; p = 0.029). An inverse and highly significant correlation was found between serum potassium and D-dimer (r = -0.21; p investigar a correlação entre os níveis séricos de D-dímero e potássio na FA aguda (FAA). Métodos: Para investigar a existência de uma potencial correlação entre os níveis séricos de potássio e D-dímero em pacientes com FAA, realizamos uma revisão retrospectiva de dados clínicos e laboratoriais relacionados a todas as visitas ao departamento de emergência devido à FAA, no ano de 2013. Resultados: Entre os 271 pacientes com FAA, aqueles com hipopotassemia (n = 98) mostraram aumento significativo nos níveis de D-dímero, quando comparados com pacientes com concentrações normais de potássio (139 versus 114 ng/mL, p = 0

  16. Arterio-venous gradients of IL-6, plasma and serum VEGF and D-dimers in human cancer

    OpenAIRE

    Salgado, R.; Benoy, I; Weytjens, R; Van Bockstaele, D.; Van Marck, E; Huget, Ph; Hoylaerts, M; Vermeulen, P.; Dirix, L Y

    2002-01-01

    The circulating angiogenic factors vascular endothelial growth factor-A, interleukin-6 and the fibrin D-dimer fragment were measured in the mesenteric vein, the uterine vein, as well as in peripheral venous and arterial samples in 21 randomly selected patients with operable colorectal, ovarian and cervical carcinoma. In addition, immunohistochemistry for vascular endothelial growth factor-A and interleukin-6 was performed on colorectal tumours of such patients. Serum and plasma vascular endot...

  17. Normal blood D-dimer concentrations: do they exclude pulmonary embolism?

    Institute of Scientific and Technical Information of China (English)

    Guo Zhiguo; Ma Qingbian; Zheng Yaan; Zhang Yumei; Ge Hongxia

    2014-01-01

    Background Although pulmonary embolism (PE) with normal blood D-dimer (DD) concentrations is considered rare,in practice the incidence may be greater than is generally believed.Overlooking PE is potentially dangerous.The aim of this study was to explore the incidence and clinical features of PE with normal DD concentrations.Methods We retrospectively analyzed the records of 29 patients with PE and normal DD concentrations from the past seven years.We here compare relevant clinical characteristics of these patients with those of patients with PE and abnormal DD concentrations.We evaluated the probabilities of differences by computing pretest probability scores (Wells score and revised Geneva score).Results The frequency of normal DD concentrations in patients with PE was 4%.Previous episode(s) of PE were more common in patients with normal DD concentrations than in those with abnormal DD concentrations (P=0.001).Fever,tachycardia,and tachypnea occurred less frequently in the former group (P<0.05) and time between onset of symptoms and DD testing was longer (P=0.001).The diagnosis of PE was delayed in 22 of the 29 cases.Nineteen and seven cases with normal DD concentrations were classified according to pretest scores as intermediate and low risk,respectively.Conclusions PE with normal DD concentrations is uncommon.Although most diagnoses of PE are ruled out by normal DD values,a small number of cases with PE are missed.A combination of pretest probability score and normal DD concentration increases the probability of making the correct diagnosis,but cannot completely exclude patients with suspected PE.When the clinical manifestations cannot be otherwise explained,clinicians should be alert to the possibility of PE with normal DD concentrations in patients with previous episode(s) of PE or a long interval between onset of symptoms and DD testing.

  18. Comparison of PCT, CRP, D-Dimer, Lactate, TNF-α, IL-1β, IL-6 and lL-10 in Development of Systemic Inflammatory Response Syndrome and Sepsis on Patients with Isolated Head Trauma and Polytrauma

    OpenAIRE

    Emine Dağlı; Ali Aydın Altunkan; Handan Birbiçer; Gülhan Orekeci Temel

    2012-01-01

    Objective: In this study, it was aimed to compare the relationship between Glasgow Coma Scale (GKS), ISS values, PCT, CRP, D-Dimer, laktat, TNF-α, IL-1β, IL-6, IL-10 in patients with polytrauma and isolated head trauma in conjunction with SIRS and sepsis. Material and Method: Total of 68 patients (32 polytrauma, 36 isolated head trauma) aged between 18-65 years were enrolled in the study. For 7 days of follow up, the biochemical parameters were analysed on the days 0, 1, 3, 5, 7 and the IS...

  19. Vitamin D, d-dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study☆

    Science.gov (United States)

    Musselwhite, Laura W.; Andrade, Bruno B.; Ellenberg, Susan S.; Tierney, Ann; Belaunzaran-Zamudio, Pablo F.; Rupert, Adam; Lederman, Michael M.; Sanne, Ian; Sierra Madero, Juan G.; Sereti, Irini

    2016-01-01

    To determine the immunological profile most important for IRIS prediction, we evaluated 20 baseline plasma biomarkers in Acquired Immunodeficiency Syndrome (AIDS) patients initiating antiretroviral therapy (ART). Patients were enrolled in a randomized, placebo-controlled ART initiation trial in South Africa and Mexico to test whether maraviroc could prevent IRIS. Participants were classified prospectively as having IRIS within 6 months of ART initiation. Twenty plasma biomarkers were measured at study enrollment for 267 participants. Biomarkers were tested for predicting IRIS with adjustment for covariates chosen through forward stepwise selection. Sixty-two participants developed IRIS and of these 19 were tuberculosis (TB)-IRIS. Baseline levels of vitamin D and higher d-dimer, interferon gamma (IFNγ), and sCD14 were independently associated with risk of IRIS in multivariate analyses. TB-IRIS cases exhibited a distinct biosignature from IRIS related to other pathogens, with increased levels of C-reactive protein (CRP), sCD14, IFNγ, and lower levels of Hb that could be captured by a composite risk score. Elevated markers of Type 1 T helper (Th1) response, monocyte activation, coagulation and low vitamin D were independently associated with IRIS risk. Interventions that decrease immune activation and increase vitamin D levels warrant further study. PMID:26981576

  20. Association of coronary heart disease with age-adjusted aortocoronary calcification in patients with familial hypercholesterolaemia

    DEFF Research Database (Denmark)

    Jensen, J M; Gerdes, Lars Ulrik; Jensen, H K;

    2000-01-01

    OBJECTIVES: Existing algorithms of risk of coronary heart disease (CHD) do not pertain to patients with familial hypercholesterolaemia (FH), whose arteries have been exposed to hypercholesterolaemia since birth. We studied a cohort of FH patients to compare four diagnostic models of CHD......: traditional risk factors of CHD (age, sex, cholesterol, hypertension, smoking and body mass index), cholesterol year score, and aortic as well as coronary calcium measured by spiral computed tomography (CT). SUBJECTS: We invited 88 individuals with molecularly defined FH of whom 80 (91%) decided...... to participate. RESULTS: Analysis of receiver operating characteristic curves showed that the age-adjusted coronary calcium score was more strongly associated with clinical manifestations of CHD than were traditional risk factors (P

  1. 20 CFR 404.233 - Adjustment of your guaranteed alternative when you become entitled after age 62.

    Science.gov (United States)

    2010-04-01

    ... when you become entitled after age 62. 404.233 Section 404.233 Employees' Benefits SOCIAL SECURITY... Guaranteed Alternative for People Reaching Age 62 After 1978 But Before 1984 § 404.233 Adjustment of your guaranteed alternative when you become entitled after age 62. (a) If you do not become entitled to...

  2. Associations between Emotional Intelligence, Socio-Emotional Adjustment, and Academic Achievement in Childhood: The Influence of Age

    Science.gov (United States)

    Brouzos, Andreas; Misailidi, Plousia; Hadjimattheou, Anastasia

    2014-01-01

    This study examined the relationship between trait emotional intelligence (EI) with children's socio-emotional adjustment at school and academic achievement. Children aged 8 to 10 (n = 106) and 11 to 13 years (n = 99) completed the youth version of the Emotional Quotient Inventory (EQ-i: YV). Their socio-emotional adjustment was measured with…

  3. Use of age-adjusted rates of suicide in time series studies in Israel.

    Science.gov (United States)

    Bridges, F Stephen; Tankersley, William B

    2009-01-01

    Durkheim's modified theory of suicide was examined to explore how consistent it was in predicting Israeli rates of suicide from 1965 to 1997 when using age-adjusted rates rather than crude ones. In this time-series study, Israeli male and female rates of suicide increased and decreased, respectively, between 1965 and 1997. Conforming to Durkheim's modified theory, the Israeli male rate of suicide was lower in years when rates of marriage and birth are higher, while rates of suicide are higher in years when rates of divorce are higher, the opposite to that of Israeli women. The corrected regression coefficients suggest that the Israeli female rate of suicide remained lower in years when rate of divorce is higher, again the opposite suggested by Durkheim's modified theory. These results may indicate that divorce affects the mental health of Israeli women as suggested by their lower rate of suicide. Perhaps the "multiple roles held by Israeli females creates suicidogenic stress" and divorce provides some sense of stress relief, mentally speaking. The results were not as consistent with predictions suggested by Durkheim's modified theory of suicide as were rates from the United States for the same period nor were they consistent with rates based on "crude" suicide data. Thus, using age-adjusted rates of suicide had an influence on the prediction of the Israeli rate of suicide during this period.

  4. Behavioral Risk Factors: Selected Metropolitan Area Risk Trends (SMART) MMSA Age-adjusted Prevalence Data (2011 to Present)

    Data.gov (United States)

    U.S. Department of Health & Human Services — 2011 to present. BRFSS SMART MMSA age-adjusted prevalence combined land line and cell phone data. The Selected Metropolitan Area Risk Trends (SMART) project uses...

  5. NCHS - Age-adjusted Death Rates for the Top 10 Leading Causes of Death: United States, 2013

    Data.gov (United States)

    U.S. Department of Health & Human Services — Age-adjusted death rates for the top 10 leading causes of death in the United States, including mortality patterns from 1999 through 2013, and by state of residence...

  6. Prothrombin Time, Activated Partial Thromboplastin Time, Fibrinogen, dan D-dimer Sebagai Prediktor Decompensated Disseminated Intravascular Coagulation Sisseminated pada Sepsis

    Directory of Open Access Journals (Sweden)

    Fenny

    2011-03-01

    Full Text Available Sepsis is a systemic response to infection especially in pneumonia case. Sepsis can cause complications such as disseminated intravascular coagulation (DIC which can be divided into compensated and decompensated DIC. The purpose of this study was to assess whether the value of prothrombin time (PT, activated partial thromboplastin time (aPTT, fibrinogen, and D-dimer levels can be used as predictors of decompensated DIC in sepsis patients. This study was conducted at the Laboratory of Clinical Pathology Rumah Sakit Hasan Sadikin Bandung since September 2008 to June 2010. Subjects were patients with sepsis caused by pneumonia. PT and aPTT values, fibrinogen, and D-dimer levels was recorded from all sepsis patients then patients were observed until diagnosed decompensated or non-decompensated DIC, then the value of PT, aPTT, fibrinogen and D-dimer levels in the group of decompensated DIC and non-decompensated DIC were analysed. This study used cohort design. Subjects were 39 sepsis patients (58% with outcome decompensated DIC and 28 sepsis patients (42% with outcome non-decompensated DIC. From the hemostasis parameter test out, it was found that PT, aPTT, and fibrinogen were the predictor of decompensated DIC in patients with sepsis with relative risk 240.500, 7.157, and 6.421; respectively. Conclusions, prothrombin time, aPTT, fibrinogen are the test to know coagulation activation. Hemostasis parameter to predict decompensated DIC in sepsis patients are the shorten PT, aPTT, and the increased fibrinogen

  7. D-dimer and portal vein status in splenectomized Egyptian β-thalassemia major patients: a prospective single-thalassemia center experience.

    Science.gov (United States)

    Elalfy, Mohsen Saleh; Andrawes, Nevine Gamal; Sadek, Azza Mohamad; Hussein, Omar; Abdou, Abeer

    2012-04-01

    Splenectomy is a recognized cause of portal vein thrombosis. Thirty-six β-thalassemia major (β-TM) patients were followed up for 36 months to evaluate changes in D-dimer levels (as a possible marker for thrombosis development) and portal vein status (by portal duplex ultrasound) at both early and late postlaparoscopic splenectomy periods. They were classified into group I if they were splenectomized in the study period (n = 12), or group II if they were splenectomized during the 5 years preceding the period (n = 24). In group I, D-dimer was measured 5 times: 1 day presplenectomy, the 1st week, 6th week, and 6th month postsplenectomy, and at the study end, whereas in group II, D-dimer was measured twice: at the study entry and end. Portal duplex was done 1 week postsplenectomy (group I) and at study end in both groups. Presplenectomy D-dimer levels in group I were significantly higher compared with the 6th month (P = .042) and study end (P = .03), whereas 1st week (postsplenectomy) D-dimer levels had a high mean of 3497.3 ng/mL, lowered at the 6th week (P = .017), at the 6th month (P = .008), and at study end (P = .005). D-dimer levels in group II showed no difference between study entry and end (P = .104). Portal vein "diameter and flow" were within normal findings in both groups. In this 3-year prospective study, a subclinical hypercoagulable state was detected 1 day prior to splenectomy and in the early postsplenectomy period, as evidenced by high D-dimer levels. Laparoscopic splenectomy was not associated with portal venous thrombosis either clinically or by duplex sonography. PMID:22475301

  8. The Value of D-Dimer in Diagnosis of Acute Mesenteric Ischemia and Differential Diagnosis from Acute Pancreatitis and Acute Cholecystitis

    Directory of Open Access Journals (Sweden)

    Semih Hot

    2016-03-01

    Full Text Available Objective: Because of its poor prognosis and high mor­tality rate, early diagnosis of acute mesenteric ischemia (AMI is a challenge. The value of serum markers in the diagnosis of AMI is limited and the studies related with the D-dimer test carried out in recent years. In this prospec­tive study we investigated the value of the level of plasma D-dimer in the diagnosis of AMI and the differential diag­nosis from acute pancreatitis and acute cholecystitis. Methods: We included 89 patients who admitted to our emergency department with abdominal pain. The number and the diagnosis of the patients were 17 AMI, 42 acute pancreatitis and 30 acute cholecystitis, respectively. We measured the levels of plasma D-dimer of all patients by using a latex agglutination ‘immunoassay’ method. Even­tually we calculated the sensitivity and specificity of D-dimer test in the diagnosis of AMI. Results: We determined the specificity of the D-dimer test in the differential diagnosis of AMI as 50% from acute pancreatitis, 70% from acute cholecystitis, 58.3% from all the control group and the sensitivity was 100%. Conclusion: The measurement of plasma D-dimer con­centration may be useful in the differential diagnosis of AMI from acute pancreatitis and acute cholecystitis. How­ever, to reveal the diagnostic value of D-dimer test more clearly, further studies with larger series are needed, where cut-off value is highly defined, and other patients with acute abdominal pain are added into the control group.

  9. Diagnostic accuracy of deep vein thrombosis is increased by analysis using combined optimal cut-off values of postoperative plasma D-dimer levels

    Science.gov (United States)

    JIANG, YONG; LI, JIE; LIU, YANG; ZHANG, WEIGUO

    2016-01-01

    The present study aimed to evaluate the accuracy of analysis using optimal cut-off values of plasma D-dimer levels in the diagnosis of deep vein thrombosis (DVT). A total of 175 orthopedic patients with DVT and 162 patients without DVT were included in the study. Ultrasonic color Doppler imaging was performed on lower limb veins prior to and following orthopedic surgery in order to determine the types of orthopedic conditions that were present. An enzyme-linked fluorescent assay was performed to detect the expression levels of D-dimer in plasma, and receiver operating characteristic analysis was performed to predict the occurrence of DVT on the basis of the expression levels of D-dimer. After surgery, the expression levels of D-dimer in the plasma of DVT patients were significantly higher in comparison with those in orthopedic patients without DVT (P<0.05). When the patients were divided into subgroups according to the underlying orthopedic condition, the expression levels of D-dimer in the plasma of each subgroup were higher 1 day after orthopedic surgery in comparison to those prior to surgery (P<0.05). The diagnostic accuracy achieved using combined optimal cut-off values at 1 and 3 days post-surgery was significantly higher than the accuracy when using a single optimal cut-off value (P<0.05). In conclusion, detection of D-dimer expression levels at 1 day post-orthopedic surgery may be important in predicting DVT. In addition, the diagnostic accuracy of DVT is significantly increased by analysis using combined optimal cut-off values of D-dimer plasma expression levels. PMID:27168793

  10. Admission Values of D-dimer and C-reactive Protein (CRP) Predict the Long-term Outcomes in Acute Aortic Dissection.

    Science.gov (United States)

    Mori, Kentaro; Tamune, Hidetaka; Tanaka, Hiroyuki; Nakamura, Mitsuhiro

    2016-01-01

    Objective Admission D-dimer and C-reactive protein (CRP) values have been reported to predict the short-term outcomes in acute aortic dissection (AAD). However, the association between D-dimer values and the long-term outcomes has not been investigated. Methods The primary endpoints included events determined to be all-cause death, recurrence of aortic dissection, aortic rupture, and surgical intervention for the aortic aneurysm following the first hospital discharge. We performed a receiver operating characteristic analysis and determined the optimal cut-off levels of admission D-dimer, admission CRP and peak CRP values in terms of the sensitivity and specificity for predicting the presence of events. Using the optimal cut-off values, we performed a multiple Cox analysis and investigated the hazard ratio of admission D-dimer, admission CRP and peak CRP. Patients We retrospectively identified 173 AAD patients hospitalized between January 2005 and December 2013. Results A multiple Cox regression analysis revealed that the hazard ratios were 3.4 for admission D-dimer [95% Confidence Interval (CI) 1.5 to 7.3, p=0.004] and 2.7 for admission CRP (95% CI 1.2 to 5.5, p=0.014). Conclusion Admission D-dimer and CRP values may predict the long-term outcomes in AAD. Moreover, admission D-dimer values may be a valuable marker to predict not only the short-term outcomes, but also the long-term outcomes in AAD. PMID:27432090

  11. Anticipatory Postural Adjustments in Standing Reach Tasks Among Middle-Aged Adults With Diplegic Cerebral Palsy.

    Science.gov (United States)

    Su, Ivan Y W; Chow, Daniel H K

    2016-01-01

    Previous studies reported that children with cerebral palsy (CP) exhibited premature anticipatory postural adjustments (APAs) with high variability and excessive activity in the frontal plane. To better understand the effects of gross motor functioning level on APAs over the life course, the authors examined the presence and consistency of APAs in 11 adults with diplegia at 2 functioning levels against 8 age-matched healthy adults during unilateral and bilateral reaching. Results revealed an anticipatory vertical torque (TZ) and an increased likelihood of APAs during bilateral reaching for the lower functioning group. It is postulated that APAs may first emerge in TZ in CP. Results also indicated an excessive premovement postural activity in the frontal plane in both CP groups. PMID:26730748

  12. Age-adjusted recipient pretransplantation telomere length and treatment-related mortality after hematopoietic stem cell transplantation

    Science.gov (United States)

    Calado, Rodrigo T.; Busson, Marc; Abrams, Jeffrey; Adoui, Nadir; Robin, Marie; Larghero, Jérôme; Dhedin, Nathalie; Xhaard, Alienor; Clave, Emmanuel; Charron, Dominique; Toubert, Antoine; Loiseau, Pascale; Socié, Gérard; Young, Neal S.

    2012-01-01

    Telomere attrition induces cell senescence and apoptosis. We hypothesized that age-adjusted pretransplantation telomere length might predict treatment-related mortality (TRM) after hematopoietic stem cell transplantation (HSCT). Between 2000 and 2005, 178 consecutive patients underwent HSCT from HLA-identical sibling donors after myeloablative conditioning regimens, mainly for hematologic malignancies (n = 153). Blood lymphocytes' telomere length was measured by real-time quantitative PCR before HSCT. Age-adjusted pretransplantation telomere lengths were analyzed for correlation with clinical outcomes. After age adjustment, patients' telomere-length distribution was similar among all 4 quartiles except for disease stage. There was no correlation between telomere length and engraftment, GVHD, or relapse. The overall survival was 62% at 5 years (95% confidence interval [CI], 54-70). After a median follow-up of 51 months (range, 1-121 months), 43 patients died because of TRM. The TRM rate inversely correlated with telomere length. TRM in patients in the first (lowest telomere length) quartile was significantly higher than in patients with longer telomeres (P = .017). In multivariate analysis, recipients' age (hazard ratio, 1.1; 95% CI, .0-1.1; P = .0001) and age-adjusted telomere length (hazard ratio, 0.4; 95% CI; 0.2-0.8; P = .01) were independently associated with TRM. In conclusion, age-adjusted recipients' telomere length is an independent biologic marker of TRM after HSCT. PMID:22948043

  13. Plasma levels of D-dimer in a 5-year-old girl with systemic juvenile idiopathic arthritis: A case report and literature review

    Science.gov (United States)

    XU, QIANG; LIN, CHANG-SONG

    2016-01-01

    The present study reported high levels of D-dimer associated with multiple joint pain in a 5-year-old patient with systemic juvenile idiopathic arthritis (JIA). While treatment with methotrexate (MTX), hydroxychloroquine and methylprednisolone was found to reduce the D-dimer level and alleviated joint pain, the fever was not effectively controlled. Addition of etanercept to the treatment regimen from week 2 resulted in a clinical remission. Following 4–6 months of therapy, the D-dimer level of the patient returned to the normal range, and symptoms of noticeable joint pain and fever were absent. A literature search showed that the levels of D-dimer may be associated with JIA disease severity, and can serve as a prognostic biomarker for JIA treatment. In conclusion, the present study demonstrated that, while MTX therapy effectively reduced D-dimer levels, addition of etanercept to the treatment regimen was required to achieve a long-lasting remission of clinical symptoms, including fever. PMID:26998032

  14. Comparison of PCT, CRP, D-Dimer, Lactate, TNF-α, IL-1β, IL-6 and lL-10 in Development of Systemic Inflammatory Response Syndrome and Sepsis on Patients with Isolated Head Trauma and Polytrauma

    Directory of Open Access Journals (Sweden)

    Emine Dağlı

    2012-12-01

    Full Text Available Objective: In this study, it was aimed to compare the relationship between Glasgow Coma Scale (GKS, ISS values, PCT, CRP, D-Dimer, laktat, TNF-α, IL-1β, IL-6, IL-10 in patients with polytrauma and isolated head trauma in conjunction with SIRS and sepsis. Material and Method: Total of 68 patients (32 polytrauma, 36 isolated head trauma aged between 18-65 years were enrolled in the study. For 7 days of follow up, the biochemical parameters were analysed on the days 0, 1, 3, 5, 7 and the ISS, GCS score and growth rates of SIRS and sepsis were recorded. Results: It was demonstrated that for patients with isolated head trauma, SIRS (80.6%, sepsis (38.9% and mortality values (71.4% were higher and there is a statistically important linear and inverse relationship between ISS and GCS values (p<0.05. During sepsis and SIRS phases, CRP elevated in both groups, whereas PCT only in the polytrauma group. D-Dimer values were investigated high in both groups, but atypically decreased on day 3 in isolated head trauma group. Lactate, TNF-α and, IL-1β were within reference values, IL-6 and IL-10 values were elevated in both groups but were higher in the polytrauma group. Conclusion: Although multiple variations were detected in serum markers of pro-inflamatory and acute phase proteins, we thought that these are inadequate in predicting mortality and complications such as SIRS and sepsis.

  15. Measurement of fractionated plasma metanephrines for exclusion of pheochromocytoma: Can specificity be improved by adjustment for age?

    Directory of Open Access Journals (Sweden)

    Gafni Amiram

    2005-02-01

    Full Text Available Abstract Background Biochemical testing for pheochromocytoma by measurement of fractionated plasma metanephrines is limited by false positive rates of up to 18% in people without known genetic predisposition to the disease. The plasma normetanephrine fraction is responsible for most false positives and plasma normetanephrine increases with age. The objective of this study was to determine if we could improve the specificity of fractionated plasma measurements, by statistically adjusting for age. Methods An age-adjusted metanephrine score was derived using logistic regression from 343 subjects (including 33 people with pheochromocytoma who underwent fractionated plasma metanephrine measurements as part of investigations for suspected pheochromocytoma at Mayo Clinic Rochester (derivation set. The performance of the age-adjusted score was validated in a dataset of 158 subjects (including patients 23 with pheochromocytoma that underwent measurements of fractionated plasma metanephrines at Mayo Clinic the following year (validation dataset. None of the participants in the validation dataset had known genetic predisposition to pheochromocytoma. Results The sensitivity of the age-adjusted metanephrine score was the same as that of traditional interpretation of fractionated plasma metanephrine measurements, yielding a sensitivity of 100% (23/23, 95% confidence interval [CI] 85.7%, 100%. However, the false positive rate with traditional interpretation of fractionated plasma metanephrine measurements was 16.3% (22/135, 95% CI, 11.0%, 23.4% and that of the age-adjusted score was significantly lower at 3.0% (4/135, 95% CI, 1.2%, 7.4% (p Conclusion An adjustment for age in the interpretation of results of fractionated plasma metanephrines may significantly decrease false positives when using this test to exclude sporadic pheochromocytoma. Such improvements in false positive rate may result in savings of expenditures related to confirmatory imaging.

  16. VIDAS D-dimer in combination with clinical pre-test probability to rule out pulmonary embolism. A systematic review of management outcome studies.

    Science.gov (United States)

    Carrier, Marc; Righini, Marc; Djurabi, Reza Karami; Huisman, Menno V; Perrier, Arnaud; Wells, Philip S; Rodger, Marc; Wuillemin, Walter A; Le Gal, Grégoire

    2009-05-01

    Clinical outcome studies have shown that it is safe to withhold anticoagulant therapy in patients with suspected pulmonary embolism (PE) who have a negative D-dimer result and a low pretest probability (PTP) either using a PTP model or clinical gestalt. It was the objective of the present study to assess the safety of the combination of a negative VIDAS D-dimer result in combination with a non-high PTP using the Wells or Geneva models to exclude PE. A systematic literature search strategy was conducted using MEDLINE, EMBASE, the Cochrane Register of Controlled Trials and all EBM Reviews. Seven studies (6 prospective management studies and 1 randomised controlled trial) reporting failure rates at three months were included in the analysis. Non-high PTP was defined as "unlikely" using the Wells' model, or "low/intermediate" PTP using either the Geneva score, the Revised Geneva Score, or clinical gestalt. Two reviewers independently extracted data onto standardised forms. A total of 5,622 patients with low/intermediate or unlikely PTP were assessed using the VIDAS D-dimer. PE was ruled out by a negative D-dimer test in 2,248 (40%, 95% confidence intervals [CI] 38.7 to 41.3%) of them. The three-month thromboembolic risk in patients left untreated on the basis of a low/intermediate or unlikely PTP and a negative D-dimer test was 3/2,166 (0.14%, 95% CI 0.05 to 0.41%). In conclusion, the combination of a negative VIDAS D-dimer result and a non-high PTP effectively and safely excludes PE in an important proportion of outpatients with suspected PE. PMID:19404542

  17. The Value of D-Dimer in Diagnosis of Acute Mesenteric Ischemia and Differential Diagnosis from Acute Pancreatitis and Acute Cholecystitis

    OpenAIRE

    Semih Hot; Nüvit Duraker; Ayhan Sarı; Kenan Çetin

    2016-01-01

    Objective: Because of its poor prognosis and high mor­tality rate, early diagnosis of acute mesenteric ischemia (AMI) is a challenge. The value of serum markers in the diagnosis of AMI is limited and the studies related with the D-dimer test carried out in recent years. In this prospec­tive study we investigated the value of the level of plasma D-dimer in the diagnosis of AMI and the differential diag­nosis from acute pancreatitis and acute cholecystitis. Methods: We included 89 patients w...

  18. Study on the change and relationship between plasma D-dimer and homocysteine levels in patients with acute cerebral vascular accident

    International Nuclear Information System (INIS)

    Objective: To study the clinical significance of the changes and the relationships between plasma D-dimer (D-D) and Homocysteine (Hcy) expression in patients with acute cerebral infarction and acute cerebral hemorrhage. Methods: Plasma D-D (with ELISA) and Hcy (with CLIA) levels were measured in 397 patients with cerebral infarction, 122 patients with cerebral hemorrhage and 30 controls.Results 1) The mean level of the plasma D-D and Hcy in patients with acute cerebral infarction was 5.20±0.92μg/L and 21.23±13.54 μmol/L respectively, which was significant higher than that in controls and patients with acute cerebral hemorrhage. 2) Higher expressing of D-D and Hcy was found in 101 (25.4%) and 140 (35.3%) cases of acute cerebral infarction patients. The data in acute cerebral hemorrhage group was 17 (13.9%) and 27 (22.1%) respectively. There was significant difference between two groups, P<0.01. 3) There was not correlations with the expression level of D-D and Hcy in patients with acute cerebral infarction and patients with acute cerebral hemorrhage. 4) The expressing level of the Plasma D-D in acute cerebral infarction patients was not significant difference in both age and sex. The expressing level of Hcy in male was higher than that in female. There was not significant difference in the expressing level of Hcy in different age. Conclusion: The levels of plasma D-D and Hcy in patients with acute cerebral infarction significantly in creased, but there were not correlations between the levels of the two parameters. (authors)

  19. The prediction role of D-dimer in recurrence of venous thromboembolism 1-year after anticoagulation discontinuing following idiopathic deep vein thrombosis

    Directory of Open Access Journals (Sweden)

    Babak Tamizifar

    2014-01-01

    Full Text Available Background: After discontinuing oral anticoagulant therapy (OAT, the recurrence of venous thromboembolism (VTE is greatest in the 1 st year and gradually diminishes. D-dimer assay was proposed to be effective in selecting patients with idiopathic DVT. The aim of this study was to determine the rate of VTE recurrence after discontinuing OAT according to the results of D-dimer. Materials and Methods: This prospective study was conducted in patients with a first episode of symptomatic proximal deep vein thrombosis (DVT who had received OAT for at least 3 months. Patients were re-evaluated at 1 st , 6 th and 12 th months of their follow-up. At the first (T0 and 30-day (T1 visits, venous blood samples were taken for D-dimer test. At each follow-up visit, we examined patients for clinical symptoms or signs of recurrent VTE, bleeding, postthrombotic manifestations, adherence to treatment, and concomitant analgesic or antiinflammatory therapy. The endpoint outcomes were VTE recurrence and complete of this survey follow-ups. Results: A total of 68 eligible patients was enrolled. Four patients (two patients need to use long-term oral anticoagulation, and two patients lost their first follow-up were excluded. At T0, D-dimer and compression ultrasonongraphy (CUS was normal in 28 patients (44%. Moreover, 36 patients had abnormal D-dimer but normal CUS. A follow-up of 12 months was available in 44 patients. During the follow-up, three recurrent events were recorded. All Recurrent events were ipsilateral DVT. Among these index cases, all had an abnormal D-dimer at either T0 and/or T1. The recurrence rate was higher in males than in females (8.6% vs. 2.2%, P = 0.04 with an abnormal D-dimer at T0 and/or T1 with a multivariate hazard ratio of 2.1 (95% confidence intervals [CI]: 1.2-5.2; P = 0.02. Patients older than 65 years had a higher rate of events than younger and hazard ratio was about 3.8 (95% CI: 2.1-4.2; P = 0.02. Patients with recurrences had higher

  20. The relationship of D-dimer levels with risk for developing deep-vein thrombosis and/or pulmonary thromboembolism after orthopaedic trauma surgery

    International Nuclear Information System (INIS)

    Deep venous thrombosis (DVT) and pulmonary embolism (PE) are common complications in trauma patients. Fibrin-related markers (FRMs), such as fibrin and fibrinogen degradation products (FDPs), D-dimer, and soluble fibrin (SF), are considered to be useful for the diagnosis of thrombosis (DVT). We report on 3-month follow-up of fibrinolytic activity after Orthopaedic Trauma Surgery (OTS). Patients who entered the study were divided into (group 1) patients who did not develop DVT/PE after OTS while patients who developed DVT/PE were included in (group 2). Blood samples were obtained on day of surgery and postoperative days 1, 7 and 30, and assayed for blood counts, C-reactive protein (CRP), and Ddimers. Demographic and clinical data were also collected. Postoperative levels of Ddimers of both groups increased on day 1, and remained elevated on day 30. Postoperative levels of D-dimers on day 1, 7 and 30 were higher in group 2 (p<0.05). There were no differences in perioperative levels of CRP between groups, and they correlated with D-dimers both preoperatively and on day 30. Taken together, these data suggest that orthopaedic trauma surgery induced an activation of coagulation and fibrinolysis. This situation lasts at least as late as 30 days after surgery. The D-dimer levels were significantly higher in patients developing DVT/PE post OTS. (author)

  1. The predictive values of D-dimer for the early prognosis of the acute myocardial infarction(AMI):a review of 3134 AMI patients

    Institute of Scientific and Technical Information of China (English)

    杨军

    2013-01-01

    Objective To investigate whether D-dimer could be an early warning signal for patients with acute myocardial infarction(AMI),then may be helpful in risk accessment in emergency department. Methods Three thousand one hundred and thirty-four emergency AMI cases admitted to

  2. High levels of D-dimer correlated with disease status and poor prognosis of inoperable metastatic colorectal cancer patients treated with bevacizumab

    Directory of Open Access Journals (Sweden)

    Liming Zhu

    2014-01-01

    Conclusion: High levels of plasma baseline D-dimer correlated with high tumor load, advanced disease status and poor prognosis of inoperable mCRC patients treated with bevacizumab. However, clinical research on a much larger cohort of patients will be required to verify these findings.

  3. Combined use of clinical pre-test probability and D-dimer test in the diagnosis of preoperative deep venous thrombosis in colorectal cancer patients

    DEFF Research Database (Denmark)

    Stender, Mogens; Frøkjaer, Jens Brøndum; Hagedorn Nielsen, Tina Sandie;

    2008-01-01

    The preoperative prevalence of deep venous thrombosis (DVT) in patients with colorectal cancer may be as high as 8%. In order to minimize the risk of pulmonary embolism, it is important to rule out preoperative DVT. A large study has confirmed that a negative D-dimer test in combination with a low...

  4. Drugs prescribed by general practitioners according to age, gender and socioeconomic status after adjustment for multimorbidity level

    DEFF Research Database (Denmark)

    Skoog, Jessica; Midlöv, Patrik; Beckman, Anders;

    2014-01-01

    BackgroundAge, gender and socioeconomic status have been shown to be associated with the use of prescription drugs, even after adjustment for multimorbidity. General practitioners have a holistic and patient-centred perspective and our hypothesis is that this may reflect on the prescription...... of drugs. In Sweden the patient may seek secondary care without a letter of referral and the liability of the prescription of drugs accompanies the patient, which makes it suitable for this type of research. In this study we examine the odds of having prescription drug use in the population and the rates...... of prescription drugs among patients, issued in primary health care, according to age, gender and socioeconomic status after adjustment for multimorbidity level.MethodData were collected on all individuals above 20 years of age in Östergötland county with about 400 000 inhabitants in year 2006. The John Hopkins...

  5. Children Conceived by Gamete Donation: Psychological Adjustment and Mother-child Relationships at Age 7

    OpenAIRE

    Golombok, Susan; Readings, Jennifer; Blake, Lucy; Casey, Polly; Mellish, Laura; Marks, Alex; Jadva, Vasanti

    2011-01-01

    An increasing number of babies are being born using donated sperm, where the child lacks a genetic link to the father, or donated eggs, where the child lacks a genetic link to the mother. This study examined the impact of telling children about their donor conception on mother-child relationships and children’s psychological adjustment. Assessments of maternal positivity, maternal negativity, mother-child interaction and child adjustment were administered to 32 egg donation, 36 donor insemina...

  6. Changes of coagulation and fibrinolysis in middle-old aged patients with nonvalvular atrial fibrillation

    International Nuclear Information System (INIS)

    Objective: To evaluate the changes of coagulation and fibrinolysis function in the middle-old aged patients with nonvalvular atrial fibrillation. Methods: The levels of D-Dimer and tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) were detected in 92 middle-aged patients with nonvalvular atrial fibrillation (AF group) and 60 patients with sinus rhythm (control group) by immune turbidimetry and enzyme linked immunoadsorbent assay (ELISA). Univariate analysis was used to determine the differences between two groups, and covariance analysis was used to determine the factors which might affect coagulation and fibrinolysis indexes. Results: 1)The plasma levels of D-Dimer [(0.16±0.10) mg·L-1] and t-PA [(42.58± 30.28) μg·L-1] and PAI-1 [(86.03 ± 21.43) μg·L-1] in AF group were significantly higher than those in the control group [(0.10 ± 0.08) mg·L-1, (26.02±13.84) μg·L-1, (64.94±24.35) μg·L-1] (P<0.05 or P <0.001). The ratio of PAI-1/t-PA in AF group was higher than that in control group slightly. 2) After adjustment of the factors which included sex, age and plasma creatinine, uric acid, blood sugar, triglyceride and cholesterol, the levels of D-Dimer (P=0.047), t-PA (P=0.264) and PAI-1 (P=0.001) in AF group were higher than those in the control group. Conclusion: The middle-old aged patients with nonvalvular atrial fibrillation lose their balance of coagulation and fibrinolysis in the state of hypercoagulated and hypofibrinolysis. (authors)

  7. Relations of growth in effortful control to family income, cumulative risk, and adjustment in preschool-age children.

    Science.gov (United States)

    Lengua, Liliana J; Moran, Lyndsey; Zalewski, Maureen; Ruberry, Erika; Kiff, Cara; Thompson, Stephanie

    2015-05-01

    The study examined growth in effortful control (executive control, delay ability) in relation to income, cumulative risk (aggregate of demographic and psychosocial risk factors), and adjustment in 306 preschool-age children (50 % girls, 50 % boys) from families representing a range of income (29 % at- or near-poverty; 28 % lower-income; 25 % middle-income; 18 % upper-income), with 4 assessments starting at 36-40 month. Income was directly related to levels of executive control and delay ability. Cumulative risk accounted for the effects of income on delay ability but not executive control. Higher initial executive control and slope of executive control and delay ability predicted academic readiness, whereas levels, but not growth, of executive control and delay ability predicted social competence and adjustment problems. Low income is a marker for lower effortful control, which demonstrates additive or mediating effects in the relation of income to children's preschool adjustment. PMID:25253079

  8. D-dimer testing for safe exclusion and risk stratification in patients with acute pulmonary embolism in primary care

    Directory of Open Access Journals (Sweden)

    Zhou Yin

    2015-01-01

    Full Text Available Background: Safe exclusion and risk stratification are currently recommended for the initial management of patients with acute pulmonary embolism (APE. The aim of this study was to assess the safe exclusion and risk stratification value of D-dimer (DD for APE when tested at the beginning of admission. Materials and Methods: All consecutive Chinese APE patients and controls were recruited from January 2010 to December 2012. All measurements of serum indexes were made in duplicate and blinded to the patients′ status. All the 40 patients with the first episode of APE were confirmed by multi-detector computed tomographic pulmonary angiography. The plasma prothrombin time (PT, activated partial thromboplastin time, thrombin time, fibrinogen, and DD levels were measured within 24 h of admission. We used the Mann-Whitney U-test to determine the differences between groups and drew receiver operator characteristic curve to evaluate the indexes′ value in the APE screening. Results: The PT and DD in the APE group were significantly higher than those in the disease control group (P 1820 μg/L as cut-off value, the sensitivity, specificity, positive and negative predictive value was 82.5%, 75.2%, 56.9%, and 91.6%, respectively. Conclusion: The patients with APE showed significant higher DD levels compared with disease controls, suggesting a negative qualitative DD test result can safely and efficiently exclude APE in primary care.

  9. Age-adjusted recipient pretransplantation telomere length and treatment-related mortality after hematopoietic stem cell transplantation

    OpenAIRE

    Peffault de Latour, Régis; Calado, Rodrigo T.; Busson, Marc; Abrams, Jeffrey; Adoui, Nadir; Robin, Marie; Larghero, Jérôme; Dhedin, Nathalie; Xhaard, Alienor; Clave, Emmanuel; Charron, Dominique; Toubert, Antoine; Loiseau, Pascale; Socié, Gérard; Young, Neal S

    2012-01-01

    Telomere attrition induces cell senescence and apoptosis. We hypothesized that age-adjusted pretransplantation telomere length might predict treatment-related mortality (TRM) after hematopoietic stem cell transplantation (HSCT). Between 2000 and 2005, 178 consecutive patients underwent HSCT from HLA-identical sibling donors after myeloablative conditioning regimens, mainly for hematologic malignancies (n = 153). Blood lymphocytes' telomere length was measured by real-time quantitative PCR bef...

  10. Age adjustment in ecological studies: using a study on arsenic ingestion and bladder cancer as an example

    Directory of Open Access Journals (Sweden)

    Guo How-Ran

    2011-10-01

    Full Text Available Abstract Background Despite its limitations, ecological study design is widely applied in epidemiology. In most cases, adjustment for age is necessary, but different methods may lead to different conclusions. To compare three methods of age adjustment, a study on the associations between arsenic in drinking water and incidence of bladder cancer in 243 townships in Taiwan was used as an example. Methods A total of 3068 cases of bladder cancer, including 2276 men and 792 women, were identified during a ten-year study period in the study townships. Three methods were applied to analyze the same data set on the ten-year study period. The first (Direct Method applied direct standardization to obtain standardized incidence rate and then used it as the dependent variable in the regression analysis. The second (Indirect Method applied indirect standardization to obtain standardized incidence ratio and then used it as the dependent variable in the regression analysis instead. The third (Variable Method used proportions of residents in different age groups as a part of the independent variables in the multiple regression models. Results All three methods showed a statistically significant positive association between arsenic exposure above 0.64 mg/L and incidence of bladder cancer in men and women, but different results were observed for the other exposure categories. In addition, the risk estimates obtained by different methods for the same exposure category were all different. Conclusions Using an empirical example, the current study confirmed the argument made by other researchers previously that whereas the three different methods of age adjustment may lead to different conclusions, only the third approach can obtain unbiased estimates of the risks. The third method can also generate estimates of the risk associated with each age group, but the other two are unable to evaluate the effects of age directly.

  11. Family relationships and the psychosocial adjustment of school-aged children in intact families

    NARCIS (Netherlands)

    E.M. Hakvoort; H.M.W. Bos; F. van Balen; J.M.A. Hermanns

    2010-01-01

    The authors investigated whether the quality of three family relationships (i.e., marital, parent-child, sibling) in intact families are associated with each other and with children's psychosocial adjustment. Data were collected by means of maternal and child reports (N = 88) using standardized inst

  12. Family Stress, Parenting Styles, and Behavioral Adjustment in Preschool-Age Adopted Chinese Girls

    Science.gov (United States)

    Tan, Tony Xing; Camras, Linda A.; Deng, Huihua; Zhang, Minghao; Lu, Zuhong

    2012-01-01

    This study seeks to extend previous research on family stress, parenting, and child adjustment to families with adopted Chinese children. In doing so, we also seek to strengthen inferences regarding the experiential underpinnings of previously obtained relationships among these variables by determining if they also occur in families where parents…

  13. Risk assessment adjusted for gestational age in maternal serum screening for Down's syndrome.

    OpenAIRE

    Gardosi, J.; Mongelli, M.

    1993-01-01

    OBJECTIVE--To investigate the relation between errors in calculation of gestational age and assessment of risk of Down's syndrome and to analyse the implications for screening programmes. DESIGN--Retrospective analysis of dating of gestational age by menstrual history v ultrasound scan. Computer program with maternal age and concentrations of alpha fetoprotein and free beta human chorionic gonadotrophin to calculate risk for a range of expected dates of delivery. Computer simulated prospectiv...

  14. Biological and sociological interpretations of age-adjustment in studies of higher order birth rates

    Directory of Open Access Journals (Sweden)

    Niels Keiding

    2008-07-01

    Full Text Available Several studies of the effect of education on second or third birth rates (e.g. Hoem et al. (2001 have used the concept of relative age at previous birth (B.Hoem (1996. B.Hoem's idea was to focus on the social meaning of age at previous birth. We broaden the discussion by considering other interpretations of the explanatory power of the age at previous birth, particularly via known trends in biological fecundity. A mathematical analysis of the approach reveals side effects that have not been taken sufficiently into account. Our recommendation is not to use the relative age approach without supplementing it with the more traditional approach which includes the actual age at previous birth.

  15. Diagnostic test accuracy of D-dimer for acute aortic syndrome: systematic review and meta-analysis of 22 studies with 5000 subjects

    Science.gov (United States)

    Watanabe, Hiroki; Horita, Nobuyuki; Shibata, Yuji; Minegishi, Shintaro; Ota, Erika; Kaneko, Takeshi

    2016-01-01

    Diagnostic test accuracy of D-dimer for acute aortic dissection (AAD) has not been evaluated by meta-analysis with the bivariate model methodology. Four databases were electrically searched. We included both case-control and cohort studies that could provide sufficient data concerning both sensitivity and specificity of D-dimer for AAD. Non-English language articles and conference abstract were allowed. Intramural hematoma and penetrating aortic ulcer were regarded as AAD. Based on 22 eligible articles consisting of 1140 AAD subjects and 3860 non-AAD subjects, the diagnostic odds ratio was 28.5 (95% CI 17.6–46.3, I2 = 17.4%) and the area under curve was 0.946 (95% CI 0.903–0.994). Based on 833 AAD subjects and 1994 non-AAD subjects constituting 12 studies that used the cutoff value of 500 ng/ml, the sensitivity was 0.952 (95% CI 0.901–0.978), the specificity was 0.604 (95% CI 0.485–0.712), positive likelihood ratio was 2.4 (95% CI 1.8–3.3), and negative likelihood ratio was 0.079 (95% CI 0.036–0.172). Sensitivity analysis using data of three high-quality studies almost replicated these results. In conclusion, D-dimer has very good overall accuracy. D-dimer 500 ng/ml moderately increases the possibility of AAD. PMID:27230962

  16. Dual energy CT pulmonary blood volume assessment in acute pulmonary embolism - correlation with D-dimer level, right heart strain and clinical outcome

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, Ralf W.; Frellesen, Claudia; Schell, Boris; Lehnert, Thomas; Jacobi, Volkmar; Vogl, Thomas J.; Kerl, J.M. [Clinic of the Goethe University, Department of Diagnostic and Interventional Radiology, Frankfurt (Germany); Renker, Matthias [Clinic of the Goethe University, Department of Diagnostic and Interventional Radiology, Frankfurt (Germany); Medical University of South Carolina, Heart and Vascular Center, Ashley River Tower, Charleston, SC (United States); Ackermann, Hanns [Clinic of the Goethe University, Department of Biostatistics and Mathematical Modelling, Frankfurt (Germany); Schoepf, U.J. [Medical University of South Carolina, Heart and Vascular Center, Ashley River Tower, Charleston, SC (United States)

    2011-09-15

    To investigate the role of perfusion defect (PD) size on dual energy CT pulmonary blood volume assessment as predictor of right heart strain and patient outcome and its correlation with d-dimer levels in acute pulmonary embolism (PE). 53 patients with acute PE who underwent DECT pulmonary angiography were retrospectively analyzed. Pulmonary PD size caused by PE was measured on DE iodine maps and quantified absolutely (VolPD) and relatively to the total lung volume (RelPD). Signs of right heart strain (RHS) on CT were determined. Information on d-dimer levels and readmission for recurrent onset of PE and death was collected. D-dimer level was mildly (r = 0.43-0.47) correlated with PD size. Patients with RHS had significantly higher VolPD (215 vs. 73 ml) and RelPD (9.9 vs. 2.9%) than patients without RHS (p < 0.003). There were 2 deaths and 1 readmission due of PE in 18 patients with >5% RelPD, while no such events were found for patients with <5% RelPD. Pulmonary blood volume on DECT in acute PE correlates with RHS and appears to be a predictor of patient outcome in this pilot study. (orig.)

  17. Biological and sociological interpretations of age-adjustment in studies of higher order birth rates

    OpenAIRE

    Niels Keiding; Mette Gerster

    2008-01-01

    Several studies of the effect of education on second or third birth rates (e.g. Hoem et al. (2001)) have used the concept of relative age at previous birth (B.Hoem (1996)). B.Hoem's idea was to focus on the social meaning of age at previous birth. We broaden the discussion by considering other interpretations of the explanatory power of the age at previous birth, particularly via known trends in biological fecundity. A mathematical analysis of the approach reveals side effects that have not b...

  18. Quality-adjusted life years gained in patients aged over 65 years after total hip replacement

    DEFF Research Database (Denmark)

    Hørdam, Britta; Pedersen, P.U.; Søballe, Kjeld;

    2011-01-01

    Background: Total hip replacement (THR) is an effective, but also cost-intensive health care procedure for the elderly. Because of demographic changes in Western Europe, THR-associated financial investment for health care has become a question of priorities in society. To provide a quantitative...... reported significant changes in quality adjusted life years from preoperative status to 3 and 9 months after surgery. Patients in the interventions group had a significantly higher raise in qualy from baseline to 3 months after surgery. Interpretation: There was a significant gain in QALYs in both groups...

  19. Preparation and Analysis of Lyophilization Characterization of Human D-dimer%人D-二聚体的制备及其冻干性质的分析

    Institute of Scientific and Technical Information of China (English)

    武建伟; 才蕾; 王继华; 唐时幸

    2014-01-01

    以人源纤维蛋白原为原材料制备D-二聚体,将其制成冻干品并分析其冻干性质。使用凝血酶、Factor XIIIa酶解纤维蛋白原,获得交联纤维蛋白。经纤溶酶降解交联纤维蛋白,生成纤维蛋白降解产物。超滤除去纤维蛋白降解产物中的小分子物质,可获得较高纯度的D-二聚体。通过筛选和优化冻干方案,将D-二聚体制备成冻干品。经检测可知,D-二聚体冻干品可在37℃稳定保存12 d;复溶后在25℃稳定保存8 d;复溶后在4℃稳定保存30 d;复溶时,常用复溶溶剂对其复溶后的活性检测无明显影响。%D-dimer is formed by sequential action of 3 enzymes from fibrinogen. After producing D-dimer, we did the research on its lyophilization process. To produce cross-linked fibrin, fibrinogen was digested by thrombin and Factor XIIa. Then, fibrin degradation products (FDP)was prepared from cross-linked fibrin being degraded by plasmin. D-dimer was purified from FDP through ultrafiltration and prepared into lyophilized powder. By optimizing the lyophilization program, lyophilized D-dimer was stable for at least 12 days at 37℃, stable for at least 8 days at 25℃ and 30 days at 4℃ after reconstitution, and not different when being dissolved by different solvent.The preparation system established in this research is feasible and efficient. Depend on its stability, lyophilized D-dimer could be provided as biological raw materials for further research.

  20. Declines with Age in Childhood Asthma Symptoms and Health Care Use: An Adjustment for Evaluations

    Science.gov (United States)

    Ko, Yi-An; Song, Peter X. K.; Clark, Noreen M.

    2014-01-01

    Rationale: Asthma is a variable condition with an apparent tendency for a natural decline in asthma symptoms and health care use occurring as children age. As a result, asthma interventions using a pre-post design may overestimate the intervention effect when no proper control group is available. Objectives: Investigate patterns of natural decline…

  1. Neonatal mortality risk associated with preterm birth in East Africa, adjusted by weight for gestational age

    DEFF Research Database (Denmark)

    Marchant, Tanya; Willey, Barbara; Katz, Joanne;

    2012-01-01

    Low birth weight and prematurity are amongst the strongest predictors of neonatal death. However, the extent to which they act independently is poorly understood. Our objective was to estimate the neonatal mortality risk associated with preterm birth when stratified by weight for gestational age ...

  2. Adjusting for car occupant injury liability in relation to age, speed limit, and gender-specific driver crash involvement risk.

    Science.gov (United States)

    Keall, Michael; Frith, William

    2004-12-01

    It is well established that older drivers' fragility is an important factor associated with higher levels of fatal crash involvement for older drivers. There has been less research on age-related fragility with respect to the sort of minor injuries that are more common in injury crashes. This study estimates a quantity that is related to injury fragility: the probability that a driver or a passenger of that driver will be injured in crashes involving two cars. The effects of other factors apart from drivers' fragility are included in this measure, including the fragility of the passengers, the crashworthiness of cars driven, seatbelt use by the occupants, and characteristics of crashes (including configuration and impact speed). The car occupant injury liability estimates appropriately includes these factors to adjust risk curves by age, gender, and speed limit accounting for overrepresentation in crashes associated with fragility and these other factors. PMID:15545071

  3. Stroke Prevalence, Mortality and Disability-Adjusted Life Years in Adults Aged 20-64 Years in 1990-2013

    DEFF Research Database (Denmark)

    Krishnamurthi, Rita V; Moran, Andrew E; Feigin, Valery L;

    2015-01-01

    in younger adults. OBJECTIVES: This study aims to estimate prevalence, mortality and disability-adjusted life years (DALYs) and their trends for total, ischemic stroke (IS) and hemorrhagic stroke (HS) in the world for 1990-2013 in adults aged 20-64 years. METHODOLOGY: Stroke prevalence, mortality and DALYs.......8 (95% UI 16.9-22.6) and 13.7 (95% UI 12.1-15.9)) per 100,000). No significant change was detected in IS death rates among younger adults. The total DALYs from all strokes in those aged 20-64 years was 51,429,440 (95% UI 46,561,382-57,320,085). Globally, there was a 24.4% (95% UI 16.6-33.8) increase...... services for stroke is required to substantially narrow these disparities. © 2015 S. Karger AG, Basel....

  4. Should we adjust for gestational age when analysing birth weights? The use of z-scores revisited.

    Science.gov (United States)

    Delbaere, Ilse; Vansteelandt, Stijn; De Bacquer, Dirk; Verstraelen, Hans; Gerris, Jan; De Sutter, Petra; Temmerman, Marleen

    2007-08-01

    Birth weight is the single most important risk indicator for neonatal and infant mortality and morbidity, which has led to the idiom that 'every ounce counts'. Birth weight in turn, however, tends to vary widely across populations as a result of differential fetal growth velocity with such demographic factors as ethnicity, maternal and paternal height and altitude of residence. Accordingly, it has been acknowledged that the appraisal of birth weight should rely on its position relative to the birth weight distribution of the background population. This is commonly done by standardizing birth weight through its deviation from the population mean in the given gestational age stratum, as can be obtained from population-customized birth weight nomograms. This issue was recently revisited in 'Human Reproduction' through a plea for reporting birth weight as z-scores. In this article, we argue that adjustment for factors, such as gestational age, which may lie on the causal pathway from exposures present at the time of conception [e.g. single-embryo transfer (SET) versus double-embryo transfer (DET)] to birth weight, may induce bias, regardless of whether the adjustment happens via stratification, regression or through the use of z-scores.

  5. 死胎患者产前母体D-二聚体水平变化的相关性研究%Correlation Study of Antepartum D-dimer Levels in Stillbirth Patients

    Institute of Scientific and Technical Information of China (English)

    王欲; 杜鹃

    2011-01-01

    目的 探讨死胎患者分娩前母体D-二聚体水平的变化.方法比较27例死胎患者和293例健康孕妇产前凝血与纤溶检验学指标的差异,分析死胎患者产前D-二聚体浓度与年龄、孕次、产次、孕周、血小板计数、凝血功能、肝脏功能等临床指标的相关性.结果死胎患者的产前母体D-二聚体水平[409(102~18 021)μg/L]高于健康孕妇[216(1O~850)μg/L](P=0.000),而凝血酶原时间、凝血酶原时间活动度、凝血酶原标准化比值、活化部分凝血酶原时间、纤维蛋白原含量、凝血酶凝结时间与健康孕妇比较无统计学差异(P>0.05).死胎患者D-二聚体水平与年龄、孕次、产次、孕周、血小板计数、凝血功能(凝血酶原时间、凝血酶原时间活动度、凝血酶原标准化比值、活化部分凝血酶原时间、纤维蛋白原、凝血酶凝结时间)、肝脏功能(白蛋白、球蛋白、谷丙转氨酶、谷草转氨酶、碱性磷酸酶、胆碱酯酶、总胆红素)等18项指标均不相关(r分别为0.114、0.239、0.174、-0.182、-0.268、-0.160、0.267、0.006、-0.131、-0.204、-0.023、-0.277、-0.069、0.165、0.249、-0.041、-0.103、-0.016,P均>0.05).结论死胎患者分娩前D-二聚体水平升高,母体血液不但呈高凝状态,继发性纤维蛋白溶解也增强.%Abstract Objective To investigate the antepartum variation of D-dimer in stillbirth patients. Methods We compared the indicators of coagulation and fibrinolysis between stillbirth pregnant women (n = 27) and normal pregnant women (n = 293), and analysed the correlation between antepartum D-dimer concentration and maternal age, gravidity, parity, gestational weeks,platelet count,coagulation function,liver function in stillbirth patients. Results D-dimer concentration in stillbirth pregnant women were higher than that in normal pregnant women (P = 0.000), and there was no statistical difference in prothrombin time, prothrombin time activity

  6. [Elderly residents in homes for the aged: adjustment in the light of Callista Roy].

    Science.gov (United States)

    Freitas, Maria Célia de; Guedes, Maria Vilani Cavalcante; de Galiza, Francisca Tereza; Nogueira, Jéssica de Menezes; Onofre, Marília Ribeiro

    2014-01-01

    This study aimed to evaluate the adaptation of elderly individuals voluntarily reside in Institution for the Aged (LTCF) in the city of Fortaleza-CE, based on the theoretical model of Roy. Descriptive study, in a IPLI involving thirteen elderly residents. Data collect was through interviews in the months of October and December 2011 and organized by thematic content analysis. The following themes has emerged: I Physical subdivided into body sensation and body image; Staff and I, subdivided into self-consistency and auto ideal be moral-ethical-spiritual. Thus, the option to live in ILPI not effectively changed the lives of elderly people. They managed to adapt to the local and coexist well with internal and external stimuli.

  7. 产后大出血患者治疗中D-二聚体监测%Detection of D-dimer During the Treatment of Postpartum Hemorrhage

    Institute of Scientific and Technical Information of China (English)

    颜小平; 黄波; 黄琳珊

    2015-01-01

    目的:动态监测D-二聚体水平,探讨其在产后大出血患者临床诊疗中的意义。方法:对19例产后大出血患者连续监测产前、产后1h、2h、4h、8h、24h的血浆D-二聚体、PT、APTT、PLT等指标,了解其峰值水平和持续时间,以及峰值下降的变化趋势。以患者产前PT、APTT、PLT、D-二聚体的平均值为对照组,产后大出血后连续监测PT、APTT、PLT、D-二聚体的平均值为观察组,进行结果分析。结果:动态观察组D-二聚体的浓度最先升高,自产后1h开始明显高于对照组(P<0.01),4h达到峰值,随着治疗逐渐下降,但8h、24h仍明显高于对照组(P<0.01),且其变化趋势最敏感;随后PLT下降及APPT、PT升高,其变化趋势、敏感性相对较差。结论:动态监测D-二聚体的水平变化,可以作为产后大出血诊疗时评价疗效及判断预后的较好指标。%Objective: To detect the level of D-dimer dynamically and discuss its significance during the treat-ment of postpartum hemorrhage.Methods: keep detecting D-dimer,PT,APTT,PLT and other indexes of plasma of 19 cases of patients of postpartum hemorrhage in 1h,2h,4h,8h and 24h antepartum and postpartum,learn its peak level , time of duration,and the trend of peak decline. Take the average value of PT,APTT,PLT and D-dimer in ante par-tum as control group,and the average value of PT,APTT,PLT and D-dimer detected continuously in postpartum as the observation group and analyze the results.Results: the concentration of D-dimer of the dynamic observation group goes up firstly,and it becomes obviously higher than that of control group since the first hour postpartum (P<0.01) ,it reaches the peak in 4h and then declines gradually with the going on of the treatment,but it is still greatly higher than control group in 8h and 24h (P<0.01),and it changing trend is most sensitive. And then PLT declines and APPT,PT goes up,the changing trend and sensitivity is

  8. Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy

    DEFF Research Database (Denmark)

    Grund, Birgit; Baker, Jason V; Deeks, Steven G;

    2016-01-01

    BACKGROUND: Despite effective antiretroviral treatment (ART), HIV-positive individuals are at increased risk of serious non-AIDS conditions (cardiovascular, liver and renal disease, and cancers), perhaps due in part to ongoing inflammation and/or coagulation. To estimate the potential risk...... reduction in serious non-AIDS conditions or death from any cause that might be achieved with treatments that reduce inflammation and/or coagulation, we examined associations of interleukin-6 (IL-6), D-dimer, and high-sensitivity C-reactive protein (hsCRP) levels with serious non-AIDS conditions or death...

  9. Von Willebrand Factor, ADAMTS13 and D-Dimer Are Correlated with Different Levels of Nephropathy in Type 1 Diabetes Mellitus.

    Directory of Open Access Journals (Sweden)

    Caroline Pereira Domingueti

    Full Text Available We have investigated whether von Willebrand factor, ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13, and D-Dimer were associated with different levels of renal function in patients with type 1 diabetes. Patients were classified according to level of renal function through estimated glomerular filtration rate: ≥90 and <130mL/min/1,73m2, n=52 (control group, ≥60 and <90mL/min/1,73m2, n=29 (mild renal dysfunction group, <60mL/min/1,73m2, n=28 (severe renal dysfunction group; and through urinary albumin excretion: normoalbuminuria, microalbuminuria and macroalbuminuria. Von Willebrand factor, ADAMTS13, and D-Dimer plasma levels were determined by enzyme-linked immunosorbent assay. ADAMTS13 activity was determined by fluorescence resonance energy transfer assay. Von Willebrand factor levels were increased in patients with mild (P=0.001 and severe (P<0.001 renal dysfunction as compared to the control group. ADAMTS13 levels were also increased in mild (P=0.029 and severe (P=0.002 renal dysfunction groups in comparison to the control group, while ADAMTS13 activity was increased only in the severe renal dysfunction group as compared to the control group (P=0.006. No significant differences were observed among the groups regarding von Willebrand factor/ADAMTS13 ratio. ADAMTS13 activity/ADAMTS13 levels ratio was reduced in patients with mild (P=0.013 and severe (P=0.015 renal dysfunction as compared to the control group. D-Dimer levels were increased in patients with mild (P=0.006 and severe (P<0.001 renal dysfunction as compared to the control group; it was also higher in patients with severe renal dysfunction as compared to the mild renal dysfunction group (P=0.019. Similar results were found for albuminuria classification. Increased von Willebrand factor, ADAMTS13, and D-Dimer levels and decreased ADAMTS13 activity/ADAMTS13 levels ratio are associated with renal dysfunction in patients with type 1 diabetes

  10. RemoveYoung: A tool for the removal of the young stellar component in galaxies within an adjustable age cutoff

    CERN Document Server

    Gomes, Jean Michel

    2016-01-01

    The optical morphology of galaxies holds the cumulative record of their assembly history, and techniques for its quantitative characterization offer a promising avenue toward understanding galaxy formation and evolution. However, the morphology of star-forming galaxies is generally dictated by the youngest stellar component, which can readily overshine faint structural/morphological features in the older underlying stellar background (e.g., relics from recent minor mergers) that could hold important insights into the galaxy build-up process. Stripping off galaxy images from the emission from stellar populations younger than an adjustable age cutoff tcut can, therefore, provide a valuable tool in extragalactic research. RemoveYoung (RY), a publicly available tool that is presented here, exploits the combined power of integral field spectroscopy (IFS) and spectral population synthesis (SPS) toward this goal. Two-dimensional (2D) post-processing of SPS models to IFS data cubes with RY permits computation of the ...

  11. Reaction norms models in the adjusted weight at 550 days of age for Polled Nellore cattle in Northeast Brazil

    Directory of Open Access Journals (Sweden)

    Diego Pagung Ambrosini

    2014-07-01

    Full Text Available The objective of this study was to evaluate the genotype-environment interaction (GEI in the body weight adjusted to 550 days of age (W550 of Polled Nellore cattle raised in Northeastern Brazil using reaction norms (RN models. Hierarchical RN models included fixed effects for age of cow (linear and quadratic and random effects for contemporary groups (CG and additive genetic RN level and slope. Four RN hierarchical models (RNHM were used. The RNHM2S uses the solutions of contemporary groups estimated by the standard animal model (AM and considers them as environmental level for predicting the reaction norms and the RNHM1S, which jointly estimate these two sets of unknowns. Two versions were considered for both models, one with a homogeneous (Hm and another with a heterogeneous (He residual variance. The one-step homogeneous residual variance model (RNHM1SHm offered better adjustment to the data when compared with other models. For the RNHM1SHm model, estimates of additive genetic variance and heritability increased with environment improvement (260.75±75.80 kg2 to 4298.39±356.56 kg2 and 0.22±0.05 to 0.82±0.01, for low- and high-performance environments, respectively. High correlation (0.97±0.01 between the intercept and the slope of RN shows that animals with higher genetic values respond better to environment improvement. In the evaluation of breeding sires with higher genetic values in the various environments using Spearman's correlation, values between 0 and 0.98 were observed, pointing to high reclassification, especially among genetic values obtained by the animal model in comparison with those obtained via RNHM1SHm. The existence of GEI is confirmed, and so is the need for specific evaluations for low, medium and high level production environments.

  12. Age-Adjusted PSA Levels in Prostate Cancer Prediction: Updated Results of the Tyrol Prostate Cancer Early Detection Program.

    Directory of Open Access Journals (Sweden)

    Isabel Heidegger

    Full Text Available To reduce the number of unnecessary biopsies in patients with benign prostatic disease, however, without missing significant PCa the present study re-evaluates the age-dependent PSA cut-offs in the Tyrol Prostate Cancer (PCa early detection program.The study population included 2225 patients who underwent prostate biopsy due to elevated PSA levels at our department. We divided our patient collective into four age groups: ≤49 years (n = 178, 50-59 years (n = 597, 60-69 years (n = 962 and ≥70 years (n = 488. We simulated different scenarios for PSA cut-off values between 1.25 and 6 ng/mL and fPSA% between 15 and 21% for all four age groups and calculated sensitivity, specificity, confidence intervals and predictive values.PCa was detected in 1218 men (54.7%. We found that in combination with free PSA ≤21% the following PSA cut-offs had the best cancer specificity: 1.75 ng/ml for men ≤49 years and 50-59 years, 2.25 ng/ml for men aged 60-69 years and 3.25 ng/ml for men ≥70 years. Using these adjusted PSA cut-off values all significant tumors are recognized in all age groups, yet the number of biopsies is reduced. Overall, one biopsy is avoided in 13 to 14 men (number needed to screen = 13.3, reduction of biopsies = 7.5% when decision regarding biopsy is done according to the "new" cut-off values instead of the "old" ones. For the different age groups the number needed to screen to avoid one biopsy varied between 9.2 (≤49 years and 17.4 (50-59 years.With "new", fine-tuned PSA cut-offs we detect all relevant PCa with a significant reduction of biopsies compared to the "old" cut-off values. Optimization of age-specific PSA cut-offs is one step towards a smarter strategy in the Tyrol PCa Early Detection Program.

  13. Performance of first-trimester combined test for Down syndrome in different maternal age groups: reason for adjustments in screening policy?

    NARCIS (Netherlands)

    Engels, Martin; Heijboer, A.C.; Blankenstein, M.A.; Vugt, J.M.G. van

    2011-01-01

    OBJECTIVE: To evaluate the performance of the first-trimester combined test (FCT) in different maternal age groups and to discuss whether adjustments in screening policies should be made. METHODS: In this retrospective study data (n = 26 274) from a fetal medicine center on FCT (maternal age, fetal

  14. The effects of intracranial volume adjustment approaches on multiple regional MRI volumes in healthy aging and Alzheimer’s disease

    Directory of Open Access Journals (Sweden)

    Olga eVoevodskaya

    2014-10-01

    Full Text Available In neurodegeneration research, normalization of regional volumes by intracranial volume (ICV is important to estimate the extent of disease-driven atrophy. There is little agreement as to whether raw volumes, volume-to-ICV fractions or regional volumes from which the ICV factor has been regressed out should be used for volumetric brain imaging studies. Using multiple regional cortical and subcortical volumetric measures generated by Freesurfer (51 in total, the main aim of this study was to elucidate the implications of these adjustment approaches. Magnetic resonance imaging (MRI data were analyzed from two large cohorts, the population-based PIVUS cohort (N=406, all subjects age 75 and the Alzheimer disease Neuroimaging Initiative (ADNI cohort (N=724. Further, we studied whether the chosen ICV normalization approach influenced the relationship between hippocampus and cognition in the three diagnostic groups of the ADNI cohort (Alzheimer’s disease, mild cognitive impairment and healthy individuals. The ability of raw vs adjusted hippocampal volumes to predict diagnostic status was also assessed. In both cohorts raw volumes correlate positively with ICV, but do not scale directly proportionally with it. The correlation direction is reversed for all volume-to-ICV fractions, except the lateral and third ventricles. Most grey matter fractions are larger in females, while lateral ventricle fractions are greater in males. Residual correction effectively eliminated the correlation between the regional volumes and ICV and removed gender differences. The association between hippocampal volumes and cognition was not altered by ICV normalization. Comparing prediction of diagnostic status using the different approaches, small but significant differences were found. The choice of normalization approach should be carefully considered when designing a volumetric brain imaging study.

  15. A Test of the Family Stress Model on Toddler-Aged Children’s Adjustment Among Hurricane Katrina Impacted and Nonimpacted Low-Income Families

    OpenAIRE

    Scaramella, Laura V.; Sohr-Preston, Sara L.; Callahan, Kristin L.; Mirabile, Scott P.

    2008-01-01

    Hurricane Katrina dramatically altered the level of social and environmental stressors for the residents of the New Orleans area. The Family Stress Model describes a process whereby felt financial strain undermines parents’ mental health, the quality of family relationships, and child adjustment. Our study considered the extent to which the Family Stress Model explained toddler-aged adjustment among Hurricane Katrina affected and nonaffected families. Two groups of very low-income mothers and...

  16. Quantification of microangiopathic lesions in brain parenchyma and age-adjusted mean scores for the diagnostic separation of normal from pathological values in senile dementia

    International Nuclear Information System (INIS)

    Purpose: to quantify microangiopathic lesions in the cerebral white matter and to develop age-corrected cut-off values for separating normal from dementia-related pathological lesions. Materials and methods: in a memory clinic, 338 patients were investigated neuropsychiatrically by a psychological test battery and by MRI. Using a FLAIR sequence and a newly developed rating scale, white matter lesions (WMLs) were quantified with respect to localization, number and intensity, and these ratings were condensed into a score. The WML scores were correlated with the mini-mental state examination (MMSE) and clinical dementia rating (CDR) score in dementia patients. A non-linear smoothing procedure was used to calculate age-related mean values and confidence intervals, separate for cognitively intact subjects and dementia patients. Results: the WML scores correlated highly significantly with age in cognitively intact subjects and with psychometric scores in dementia patients. Age-adjusted WML scores of cognitively intact subjects were significantly different from those of dementia patients with respect to the whole brain as well as to the frontal lobe. Mean value and confidence intervals adjusted for age significantly separated dementia patients from cognitively intact subjects over an age range of 54 through 84 years. Conclusion: a rating scale for the quantification of WML was validated and age-adjusted mean values with their confidence intervals for a diagnostically relevant age range were developed. This allows an easy to handle, fast and reliable diagnosis of the vascular component in senile dementia. (orig.)

  17. Anticipatory postural adjustments are unaffected by age and are not absent in patients with the freezing of gait phenomenon.

    Science.gov (United States)

    Plate, A; Klein, K; Pelykh, O; Singh, A; Bötzel, K

    2016-09-01

    In bipedal gait, the initiation of the first step is preceded by a complex sequence of movements which shift the centre of mass of the body towards the stance foot to allow for a step of the swing foot. These anticipatory postural adjustments (APAs) have been investigated in order to elucidate movement strategies in healthy and diseased persons. We studied the influence of several external parameters (age, type of step initiation) on APAs and investigated whether Parkinsonian patients may have different APAs. As a result, we found that externally elicited steps were preceded by faster and larger APAs than self-timed steps. Parkinsonian patients without the freezing of gait (FOG) phenomenon showed overall slightly reduced APAs but did not clearly differ from patients with FOG. Multiple APAs were seen in up to 25 % of the steps of the patients and in a much lower percentage of the steps of control subjects. The results indicate that APAs are significantly influenced by the timing of a step, i.e. are larger in externally elicited steps. The patients showed an overall preserved APA pattern but slowed movements and amplitude, indicating that increased bradykinesia due to progressive illness is a plausible explanation for these findings. The freezing phenomenon is not explained by a general absence or massive reduction in APA measures. PMID:27173496

  18. RemoveYoung: A tool for the removal of the young stellar component in galaxies within an adjustable age cutoff

    Science.gov (United States)

    Gomes, J. M.; Papaderos, P.

    2016-10-01

    The optical morphology of galaxies holds the cumulative record of their assembly history, and techniques for its quantitative characterization offer a promising avenue toward understanding galaxy formation and evolution. However, the morphology of star-forming galaxies is generally dictated by the youngest stellar component, which can readily overshine faint structural/morphological features in the older underlying stellar background (e.g., relics from recent minor mergers) that could hold important insights into the galaxy build-up process. Stripping off galaxy images from the emission from stellar populations younger than an adjustable age cutoff tcut can therefore provide a valuable tool in extragalactic research. RemoveYoung (), a publicly available tool that is presented here, exploits the combined power of integral field spectroscopy (IFS) and spectral population synthesis (SPS) toward this goal. Two-dimensional (2D) post-processing of SPS models to IFS data cubes with permits computation of the spectral energy, surface brightness, and stellar surface density distribution of stellar populations older than a user-defined tcut. This suggests a variety of applications of star-forming galaxies, such as interacting or merging galaxy pairs and lower mass starburst galaxies near and far; these include blue compact and tidal dwarf galaxies.

  19. Clinical Significance of Fibrinogen and D-dimer Detection in Esophageal Cancer%食管癌患者纤维蛋白原与D-二聚体检测的临床意义

    Institute of Scientific and Technical Information of China (English)

    刘瑜; 林晓铭; 池闯; 程德志

    2012-01-01

    目的 检测并研究食管癌患者血浆中纤维蛋白原(FIB)和D-二聚体(D-dimer,DD)的变化及其临床意义.方法 对60例食管癌患者和8例健康人血浆中FIB和D-二聚体进行检测并同临床指标间进行统计学分析.结果 食管癌组血浆中的FIB和D-二聚体水平明显高于正常对照组(P<0.01);同患者的淋巴结转移情况及P-TNM分期有关(P <0.05或P<0.01),而同性别及年龄不相关(P>0.05).结论 食管癌患者的FIB及D-二聚体高于正常,并同淋巴结转移及P-TNM分期相关且与患者的生存期呈明显的负相关.%Objective To explore the clinical significance of fibrinogen and D - dimer detection in esophageal squamous cell cancer. Methods The fibrinogen and D - dimer were detected in 60 esophageal cancer patients and 8 healthy adults, and the data were analyzed with clinical indexes by SPSS. Results Levdel of fibrinogen and D - dimer in esophageal cancer patients were higher than that in healthy group (P 0. 05 ). Conclusion Compared with healthy group, significantly higher serum fibrinogen and D - dimer levels were detected in esophageal cancer patients. There was closely relationship between fibrinogen and D - dimer levels in esophageal cancer patients and lymph node metastases, p - TNM stage,and they were negatively correlated with lifetime.

  20. COMPARISON OF HEART RATE VARIABILITY ADJUSTED FOR AGE AND HEART RATE IN WOMEN WITH RHEUMATOID ARTHRITIS AND WOMEN WITHOUT RHEUMATIC DISEASES

    Directory of Open Access Journals (Sweden)

    D. S. Novikova

    2013-01-01

    Full Text Available Aim. To compare the 24-hour indicators of heart rate variability (HRV, adjusted for age and 24-hour average heart rate (HR24 in women with rheumatoid arthritis (RA and women of the control group.Material and methods. Women with RA (n=291 at the age of 20-60 were examined. Women without rheumatic diseases (n=125 were included into control group. The presence of traditional cardiovascular risk factors, the results of 24-hour ECG monitoring were assessed in addition to clinical symptoms, RA activity and severity. Transformation of the initial HRV parameters in their logarithms, and the standardization of the logarithms of age and HR24, the calculation of the exponential of the standardized logarithm were performed to remove the effects of age and heart rate on HRV.Results. Time and frequency HRV indices, adjusted for age and HP24 (HRVa in women with RA were lower than these in women of control group. HRVa decline was observed in 14–24% of women with RA. The maximum HRVa decrease was observed among the parameters that reflect an activity of parasympathetic autonomic nervous system (RMSSDn, pNN50n, HFn.Conclusion. The young and middle age women with RA differ from the women of the control group in significant decrease in the time and spectral HRV indices adjusted for age and HR24.

  1. COMPARISON OF HEART RATE VARIABILITY ADJUSTED FOR AGE AND HEART RATE IN WOMEN WITH RHEUMATOID ARTHRITIS AND WOMEN WITHOUT RHEUMATIC DISEASES

    Directory of Open Access Journals (Sweden)

    D. S. Novikova

    2015-09-01

    Full Text Available Aim. To compare the 24-hour indicators of heart rate variability (HRV, adjusted for age and 24-hour average heart rate (HR24 in women with rheumatoid arthritis (RA and women of the control group.Material and methods. Women with RA (n=291 at the age of 20-60 were examined. Women without rheumatic diseases (n=125 were included into control group. The presence of traditional cardiovascular risk factors, the results of 24-hour ECG monitoring were assessed in addition to clinical symptoms, RA activity and severity. Transformation of the initial HRV parameters in their logarithms, and the standardization of the logarithms of age and HR24, the calculation of the exponential of the standardized logarithm were performed to remove the effects of age and heart rate on HRV.Results. Time and frequency HRV indices, adjusted for age and HP24 (HRVa in women with RA were lower than these in women of control group. HRVa decline was observed in 14–24% of women with RA. The maximum HRVa decrease was observed among the parameters that reflect an activity of parasympathetic autonomic nervous system (RMSSDn, pNN50n, HFn.Conclusion. The young and middle age women with RA differ from the women of the control group in significant decrease in the time and spectral HRV indices adjusted for age and HR24.

  2. Intestinal morphology adjustments caused by dietary restriction improves the nutritional status during the aging process of rats.

    Science.gov (United States)

    de Oliveira Belém, Mônica; Cirilo, Carla Possani; de Santi-Rampazzo, Ana Paula; Schoffen, João Paulo Ferreira; Comar, Jurandir Fernando; Natali, Maria Raquel Marçal; de Almeida Araújo, Eduardo José

    2015-09-01

    During the aging process, the body's systems change structurally and loss of function can occur. Ingesting a smaller amount of food has been considered a plausible proposal for increased longevity with the quality of life. However, the effects of dietary restriction (DR) during aging are still poorly understood, especially for organs of the digestive system. This study aimed to describe the body weight, oxidative status and possible morphological changes of the intestinal wall of rats submitted to DR during the aging process (7 to 18months old). Twelve 7-month-old male Wistar rats fed ad libitum since birth were assigned to two groups: control group (CG, n=6) fed ad libitum from 7 to 18months old; and dietary restriction group (DRG, n=6) fed 50% of the amount of chow consumed by the CG from 7 to 18months old. The body weight, feed and water intake were monitored throughout the experiment. Blood, periepididymal adipose tissue (PAT) and retroperitoneal adipose tissue (RAT), and the small intestine were collected at 18months old. The blood was collected to evaluate its components and oxidative status. Sections from the duodenum and ileum were stained with HE, PAS and AB pH2.5 for morphometric analyses of the intestinal wall components, and to count intraepithelial lymphocytes (IELs), goblet cells and cells in mitosis in the epithelium. DR rats showed a reduction in weight, naso-anal length, PAT, RAT and intestinal length; however, they consumed more water. Blood parameters indicate that the DR rats remained well nourished. In addition, they showed lower lipid peroxidation. Hypertrophy of the duodenal mucosa and atrophy of the ileal mucosa were observed. The number of goblet cells and IELs was reduced, but the mitotic index remained unaltered in both duodenum and ileum. In conclusion, 50% dietary restriction for rats from 7 to 18months old contributed to improving their nutritional parameters but, to achieve this, adjustments were required in the structure of the body

  3. QuickStats: Age-Adjusted Death Rates* for Females Aged 15-44 Years, by the Five Leading Causes of Death(†) - United States, 1999 and 2014.

    Science.gov (United States)

    2016-01-01

    The age-adjusted death rate for females aged 15-44 years was 5% lower in 2014 (82.1 per 100,000 population) than in 1999 (86.5). Among the five leading causes of death, the age-adjusted rates of three were lower in 2014 than in 1999: cancer (from 19.6 to 15.3, a 22% decline), heart disease (8.9 to 8.2, an 8% decline), and homicide (4.2 to 2.8, a 33% decline). The age-adjusted death rates for two of the five causes were higher in 2014 than in 1999: unintentional injuries (from 17.0 to 20.1, an 18% increase) and suicide (4.8 to 6.5, a 35% increase). Unintentional injuries replaced cancer as the leading cause of death in this demographic group. PMID:27362608

  4. QuickStats: Age-Adjusted Death Rates* for Males Aged 15-44 Years, by the Five Leading Causes of Death(†) - United States, 1999 and 2014.

    Science.gov (United States)

    2016-01-01

    The age-adjusted death rate for males aged 15-44 years was 10% lower in 2014 (156.6 per 100,000 population) than in 1999 (174.1). Among the five leading causes of death, the age-adjusted rates for three were lower in 2014 than in 1999: cancer (from 17.1 to 12.8; 25% decline), heart disease (20.1 to 17.0; 15% decline), and homicide (15.7 to 13.8; 12% decline). The age-adjusted death rates for two of the five causes were higher in 2014 than in 1999: suicide (20.1 to 22.5; 12% increase), and unintentional injuries (from 48.7 to 51.0; 5% increase). PMID:27513718

  5. Interleukin 6 Is a Stronger Predictor of Clinical Events Than High-Sensitivity C-Reactive Protein or D-Dimer During HIV Infection

    DEFF Research Database (Denmark)

    Borges, Álvaro H; O'Connor, Jemma L; Phillips, Andrew N;

    2016-01-01

    BACKGROUND:  Interleukin 6 (IL-6), high-sensitivity C-reactive protein (hsCRP), and D-dimer levels are linked to adverse outcomes in human immunodeficiency virus (HIV) infection, but the strength of their associations with different clinical end points warrants investigation. METHODS:  Participants...... receiving standard of care in 2 HIV trials with measured biomarker levels were followed to ascertain all-cause death, non-AIDS-related death, AIDS, cardiovascular disease (CVD), and non-AIDS-defining malignancies. Hazard ratios (HRs) and 95% confidence intervals (CIs) of each end point for quartiles and log......-dimer (P = .20) as a predictor for different end points. CONCLUSIONS:  IL-6 is a stronger predictor of fatal events than of CVD and non-AIDS-defining malignancies. Adjuvant antiinflammatory and antithrombotic therapies should be tested in HIV-infected individuals....

  6. Clinical Application of D dimer in Venous Thromboembolism%D二聚体测定在静脉血栓栓塞中的临床应用

    Institute of Scientific and Technical Information of China (English)

    李恒; 张凯; 黄津; 王毅

    2011-01-01

    @@ 静脉血栓栓塞(venous thromboembolism ,VTE)是临床常见的血栓性疾病,其中最主要的是深静脉血栓栓塞症(deep venous thrombosis ,DVT)和肺栓塞(pulmonary embolism ,PE),因其发病率和致死率均高而倍受国内外医者之重视.D二聚体(D-dimer,D-D)是经凝血酶及因子作用的交联纤维蛋白经纤溶酶降解后产生的终末产物,是反映体内凝血和纤溶的理想分子标志物之一.

  7. 儿童单纯性肥胖危险因素分析及与血浆D-二聚体的相关性%Analysis of risk factors of childhood simple obesity and its relationship with plasma D-dimer

    Institute of Scientific and Technical Information of China (English)

    张晓杰; 刘静; 孙利伟; 田玉玲

    2012-01-01

    目的 探讨儿童单纯性肥胖的危险因素以及血浆D-二聚体与肥胖的相关性.方法 采用问卷调查和体格测量的方法调查2006年1月 - 2010年12月就诊的单纯性肥胖儿童530例,其中102例测定血浆D-二聚体.同时选取120例性别、年龄、地区分布相匹配的健康儿童作对照,其中89例测定血浆D-二聚体.结果 肥胖儿童出生体质量、其父母平均体质指数(BMI)均较对照组明显增高,差异有统计学意义(P均< 0.01);肥胖儿童较正常对照儿童每日运动时间少,睡眠时间和看电视时间多,差异均有统计学意义(P均< 0.01);儿童肥胖与饮食有关;肥胖儿童有心血管病家族史的比例明显高于对照组,血浆D-二聚体含量(0.85 ± 0.31)mg/L亦较对照组(0.30 ± 0.11)mg/L明显增高,差异均有统计学意义(P < 0.001).结论 儿童肥胖是遗传因素和环境因素共同作用的结果,血浆D-二聚体与儿童单纯性肥胖具有相关性.%Objective To investigate the risk factors of children simple obesity and the association of plasma D-dimer and children simple obesity. Methods The height and body weight of 530 outpatients with simple obesity were measured and questionnaire survey was processed from January 2006 to December 2010. The plasma D-dimer was tested in 102 children of them. Meanwhile, 120 healthy children were selected as control with matched gender, age and region. The plasma D-dimer was also measured. Results The birth weight and the mean parents BMI of obese children were significantly higher than those of control group (P < 0.01). Compared with the control group, obese children daily exercised less time but spent more time on sleeping and watching TV (all P < 0.01). Children obesity was diet related, and the percentage of family history of cardiovascular disease and the levels of D-dimer in obese children were significantly higher than those in control group (P < 0.001). Conclusions Obesity in children is

  8. NCHS - Age-adjusted death rates and life-expectancy at birth, (All Races, Both Sexes): United States, 1900-2013

    Data.gov (United States)

    U.S. Department of Health & Human Services — Age-adjusted death rates (deaths per 100,000) are based on the 2000 U.S. standard population. Populations used for computing death rates for 2011–2013 are...

  9. Changes in Age-Adjusted Mortality Rates and Disparities for Rural Physician Shortage Areas Staffed by the National Health Service Corps: 1984-1998

    Science.gov (United States)

    Pathman, Donald E.; Fryer, George E.; Green, Larry A.; Phillips, Robert L.

    2005-01-01

    This study assesses whether the National Health Service Corps's legislated goals to see health improve and health disparities lessen are being met in rural health professional shortage areas for a key population health indicator: age-adjusted mortality. In a descriptive study using a pre-post design with comparison groups, the authors calculated…

  10. A Computational Tool for Testing Dose-related Trend Using an Age-adjusted Bootstrap-based Poly-k Test

    OpenAIRE

    Hojin Moon; Hongshik Ahn; Kodell, Ralph L

    2006-01-01

    A computational tool for testing for a dose-related trend and/or a pairwise difference in the incidence of an occult tumor via an age-adjusted bootstrap-based poly-k test and the original poly-k test is presented in this paper. The poly-k test (Bailer and Portier 1988) is a survival-adjusted Cochran-Armitage test, which achieves robustness to effects of differential mortality across dose groups. The original poly-k test is asymptotically standard normal under the null hypothesis. However, the...

  11. Families created through surrogacy: Mother-child relationships and children’s psychological adjustment at age 7

    OpenAIRE

    Golombok, Susan; Readings, Jennifer; Blake, Lucy; Casey, Polly; Marks, Alex; Jadva, Vasanti

    2011-01-01

    Each year, an increasing number of children are born through surrogacy and thus lack a genetic and/or gestational link with their mother. This study examined the impact of surrogacy on mother-child relationships and children’s psychological adjustment. Assessments of maternal positivity, maternal negativity, mother-child interaction and child adjustment were administered to 32 surrogacy, 32 egg donation and 54 natural conception families with a 7-year-old child. No differences were found for ...

  12. A Computational Tool for Testing Dose-related Trend Using an Age-adjusted Bootstrap-based Poly-k Test

    Directory of Open Access Journals (Sweden)

    Hojin Moon

    2006-08-01

    Full Text Available A computational tool for testing for a dose-related trend and/or a pairwise difference in the incidence of an occult tumor via an age-adjusted bootstrap-based poly-k test and the original poly-k test is presented in this paper. The poly-k test (Bailer and Portier 1988 is a survival-adjusted Cochran-Armitage test, which achieves robustness to effects of differential mortality across dose groups. The original poly-k test is asymptotically standard normal under the null hypothesis. However, the asymptotic normality is not valid if there is a deviation from the tumor onset distribution that is assumed in this test. Our age-adjusted bootstrap-based poly-k test assesses the significance of assumed asymptotic normal tests and investigates an empirical distribution of the original poly-k test statistic using an age-adjusted bootstrap method. A tumor of interest is an occult tumor for which the time to onset is not directly observable. Since most of the animal carcinogenicity studies are designed with a single terminal sacrifice, the present tool is applicable to rodent tumorigenicity assays that have a single terminal sacrifice. The present tool takes input information simply from a user screen and reports testing results back to the screen through a user-interface. The computational tool is implemented in C/C++ and is applied to analyze a real data set as an example. Our tool enables the FDA and the pharmaceutical industry to implement a statistical analysis of tumorigenicity data from animal bioassays via our age-adjusted bootstrap-based poly-k test and the original poly-k test which has been adopted by the National Toxicology Program as its standard statistical test.

  13. COPD患者D-二聚体和纤维蛋白原检测的临床价值%The clinical value of D-Dimer and plasma fibrinogen in patients with chronic obstructive pulmonary disease

    Institute of Scientific and Technical Information of China (English)

    周洋; 龚建化; 黄河; 张家洪

    2012-01-01

    目的 探讨COPD患者血浆D-二聚体和纤维蛋白原检测的临床意义.方法 分别检测122例按病情严重程度分期、分度的COPD患者和30例健康对照组血浆D-二聚体和纤维蛋白原含量,分析比较各组间血浆D-二聚体和纤维蛋白原含量的差异.结果 COPD患者血浆D-二聚体和纤维蛋白原含量明显高于健康对照组(P<0.05),且急性加重期明显高于稳定期(P<0.05).在75例急性加重期COPD患者中,轻、中、重、极重度患者其血浆D-二聚体和纤维蛋白原含量间相互比较(P<0.05).结论 COPD患者存在血液高凝状态,且随着病情的加重而加重,对其监测和预防性使用抗凝、溶栓剂是非常必要的.%Objective To investigate the clinical significance of the level of plasma D-dimer and plasma fibrinogen in patients with COPD. Methods According to severity stage, the plasma D-dimer and plasma fibrinogen level were measured in 122 patients with COPD. 30 healthy subjects were included as controls. All the measures of D-dimer and plasma fibrinogen were compared between the groups. Results The levels of D-dimer and fibrinogen in 122 patients were significantly higher than those in the control group (P < 0.05 ) , and the levels of D-dimer and fibrinogen in the acute exacerbation were significantly higher than those in the stable. In 75 patients with acute exacerbation of COPD patients, the levels of plasma D-dimer and fibrinogen in mild, moderate, severe and critical patients were compared, and the group differences were statistically significant (P < 0. 05 ). Conclusion The patients with COPD are in a state of hy-percoagulability, and the levels of plasma D-dimer and fibrinogen are related to the severity of COPD attack. To monitor and preventively use anticoagulant, the use of thrombolytic agent is necessary.

  14. Licit prescription drug use in a Swedish population according to age, gender and socioeconomic status after adjusting for level of multi-morbidity

    DEFF Research Database (Denmark)

    Thorell, Kristine; Skoog, Jessica; Zielinski, Andrzej;

    2012-01-01

    There is a great variability in licit prescription drug use in the population and among patients. Factors other than purely medical ones have proven to be of importance for the prescribing of licit drugs. For example, individuals with a high age, female gender and low socioeconomic status are more...... likely to use licit prescription drugs. However, these results have not been adjusted for multi-morbidity level. In this study we investigate the odds of using licit prescription drugs among individuals in the population and the rate of licit prescription drug use among patients depending on gender, age...

  15. D-二聚体水平在系统性红斑狼疮的临床意义%The clinical significance of D-dimer in systemic lupus erythematosus

    Institute of Scientific and Technical Information of China (English)

    李春; 穆荣; 任立敏; 范文强; 任长吉; 栗占国

    2010-01-01

    目的 了解系统性红斑狼疮(SLE)患者D-二聚体水平及其临床意义.方法 选北京大学人民医院住院的261例SLE患者,收集临床及实验室资料,分析D-二聚体水平及其与SLE患者临床特征及实验室检查指标的相关性.结果 (1)除外合并肾功能不全、严重感染、弥漫性血管内凝血(DIC)、肝功能异常、妊娠及外伤等可能影响D-二聚体水平的因素,261例SLE患者中入选205例,其中D-二聚体水平升高者达69.3%(142/205).(2)D-二聚体水平升高与SLE疾病活动指数(SLEDAI)评分呈正相关(r=0.598,P=0.000),并与抗双链DNA抗体阳性、C反应蛋白(GRP)升高、补体C3、补体C4降低等有一定相关性.(3)D-二聚体水平升高者脏器损伤比例增加,狼疮性肾炎(58.5%比38.1%)、神经精神性狼疮的发生率(18.3%比4.8%)明显高于D-二聚体水平正常者.(4)伴有血栓形成的SLE患者均有D-二聚体水平升高,但不合并血栓形成者D-二聚体水平升高或正常.结论 D-二聚体水平升高可见于SLE活动期及有重要脏器损伤者,并不必然提示血栓形成.但是,伴发血栓形成的SLE患者均有D-二聚体升高.%Objective To investigate the clinical significance of D-dimer in systemic lupus erythematosus (SLE). Methods The study group comprised 261 SLE patients who were admitted in ward from 2005 to 2008 in Peking University People's Hospital Collect the clinical data to investigate the clinical significance of D-dimer. Results ( 1 ) The D-dimer levels of 56 patients were increased due to coexist reduced renal function, infections, disseminated intravascular coagulation ( DIC), liver disorders, pregnancy and injury. With the exception of above patients, 142 ( 69. 3 ) patients were increased in total 205 patients. (2)The level of D-dimer was positively correlated with SLE disease activity index( SLEDAI ) score ( r =0. 598,P =0. 000), and was associated with anti-dsDNA antibody, ESR, C-reactive protein(CRP) and complement C3

  16. Establishment of D-dimer reference intervals for pregnant women of 34 gestational weeks and its predictive value on postpartumhemorrhage%上海地区孕晚期血浆D-二聚体参考范围的建立及其预测产后出血的意义

    Institute of Scientific and Technical Information of China (English)

    蔡眉; 沈虹; 唐振华

    2015-01-01

    Objective: To establish reference intervals for D-dimer during the third trimester of pregnancy in Shang-hai women, and to analyze the factors influencing the D-dimer level for evaluating its clinical significance in postpartum hemorrhage. Methods: 6398 cases of healthy pregnant women (healthy group) of 34 weeks gestation aged 19 to 49 years from maternity department in our hospital were enrolled, they had received routine medical examination from January 2013 to July 2014. Immune turbidimetric method was used to detect the plasma D-dimer level in pregnant woman at 34 weeks gestation. Changes in D-dimer level were analyzed in 2 834 cases with obstetric risk factors (uterus anomaly, abnormal placenta, anemia, amniotic fluid anomalies, history of high blood pressure, diabetes, adverse pregnancy) (observed group) and in 347 cases of postpartum hemorrhage. Forty healthy non-pregnant women when not menstruating were enrolled as control group. Results:The median level of plasma D-dimer was 1.25 mg/L (95%CI:1.22-1.28) in 6 398 healthy pregnant women,and was 1.89 mg/L (95%CI:1.82-1.96) in 2 834 cases with obstetric risk factors. There was significant difference between the two groups (P0.05). D-dimer level was 0.30 mg/L(95%CI:0.22-0.38)in control group. Plasma D-dimer level had predictive value for postpartum hemorrhage in pregnant women with obstetric risk factors (OR=2.01, 95%CI:1.57-2.56), while had no predic-tive value for postpartum hemorrhage in healthy pregnant women. Conclusions: The 95% reference range for D-dimer in-tervals in healthy pregnant women at 34 weeks gestation is <3.05 mg/L, which is much higher than that in healthy non-pregnant women when not menstruating. D-dimer has predictive value for postpartum hemorrhage in pregnant women with obstetric risk factors.%目的:建立上海地区健康孕妇孕晚期(34孕周)血浆D-二聚体参考范围,对影响D-二聚体的相关因素进行统计分析,评价其在预测孕妇产后出血中的

  17. Methodology for adjusting scrotal circumference to 365 or 452 days of age and correlations of scrotal circumference with growth traits in beef bulls.

    Science.gov (United States)

    Bell, D J; Spitzer, J C; Bridges, W C; Olson, L W

    1996-09-01

    A retrospective analysis was conducted on data collected from 1983 through 1991, where weight and hip height were measured at start of test and every 28 d on 604 bulls completing a 224-d forage-based gain test. Scrotal circumference (SC) was measured at start of test, and at either end of test or end of the weigh period after individual bulls reached 365 d of age. Over 3 yr of this study, SC was additionally measured every 28 d. Bulls were representatives of 5 breed groups: Angus, Santa Gertrudis, Simmental, Continental (predominantly Charolais), and Zebu (predominantly Simbrah). Adjusted 365-d SC and adjusted 452-d SC were calculated by regression analysis and from formulas based on SC growth of individuals to 140 and 224 d on test, respectively. Breed group differences were observed for age of dam, birth weight, hip height, weight per day of age, average daily gain and SC at start of test, 140 d, and end of test (224 d). Scrotal circumference was positively correlated with all growth traits. Scrotal circumference was related to breed group, age, weight, hip height, average daily gain, weight per day of age, age by year, and age-by-breed group (P<0.05), as determined by regression analysis. However, omitting weight, hip height, average daily gain, and weight per day of age from the regression model did not significantly affect R2 value. Scrotal circumference growth was linear to 140 d on test; however, SC growth to 224 d on test was curvilinear. The 365-d SC predicted from the formula and from regression analysis differed for Simmental and Zebu by 0.3 and 0.4 cm, respectively (P<0.05). The 452-d SC differed for Santa Gertrudis and Zebu by 0.5 and 0.6 cm, respectively (P<0.05). Formulas based on SC growth of individuals are reasonably accurate predictors of SC at 365 and 452 d of age, when compared with more complex regression analysis. Basing SC adjustments on individual growth appears to account for variables known to affect yearling SC.

  18. Methodology for adjusting scrotal circumference to 365 or 452 days of age and correlations of scrotal circumference with growth traits in beef bulls.

    Science.gov (United States)

    Bell, D J; Spitzer, J C; Bridges, W C; Olson, L W

    1996-09-01

    A retrospective analysis was conducted on data collected from 1983 through 1991, where weight and hip height were measured at start of test and every 28 d on 604 bulls completing a 224-d forage-based gain test. Scrotal circumference (SC) was measured at start of test, and at either end of test or end of the weigh period after individual bulls reached 365 d of age. Over 3 yr of this study, SC was additionally measured every 28 d. Bulls were representatives of 5 breed groups: Angus, Santa Gertrudis, Simmental, Continental (predominantly Charolais), and Zebu (predominantly Simbrah). Adjusted 365-d SC and adjusted 452-d SC were calculated by regression analysis and from formulas based on SC growth of individuals to 140 and 224 d on test, respectively. Breed group differences were observed for age of dam, birth weight, hip height, weight per day of age, average daily gain and SC at start of test, 140 d, and end of test (224 d). Scrotal circumference was positively correlated with all growth traits. Scrotal circumference was related to breed group, age, weight, hip height, average daily gain, weight per day of age, age by year, and age-by-breed group (P<0.05), as determined by regression analysis. However, omitting weight, hip height, average daily gain, and weight per day of age from the regression model did not significantly affect R2 value. Scrotal circumference growth was linear to 140 d on test; however, SC growth to 224 d on test was curvilinear. The 365-d SC predicted from the formula and from regression analysis differed for Simmental and Zebu by 0.3 and 0.4 cm, respectively (P<0.05). The 452-d SC differed for Santa Gertrudis and Zebu by 0.5 and 0.6 cm, respectively (P<0.05). Formulas based on SC growth of individuals are reasonably accurate predictors of SC at 365 and 452 d of age, when compared with more complex regression analysis. Basing SC adjustments on individual growth appears to account for variables known to affect yearling SC. PMID:16727931

  19. Analysis of D-dimer level of normal pregnancy and pregnancy hypertension syndrome pregnant woman%正常妊娠与妊娠高血压综合征孕妇D-二聚体水平分析

    Institute of Scientific and Technical Information of China (English)

    李明兰

    2014-01-01

    Objective:To analyze the difference of D-dimer level of normal pregnancy and pregnancy hypertension syndrome pregnant woman,and to explore the influence of hypertension on D-two dimer level of pregnant women.Methods:128 pregnant women were selected from March 2010 to October 2013.According to with hypertension or not,they were divided into the pregnancy induced hypertension syndrome group(60 cases) and the normal pregnancy group(68 cases),at the same time,70 healthy women were selected as the control group.We compared the plasma D-dimer level of the three groups.Results:The D-dimer level of pregnancy induced hypertension group and normal pregnancy group were significantly higher than those of the control group(P<0.05,P<0.01).The D-dimer level of pregnancy induced hypertension group were significantly higher than that of normal pregnancy group(P<0.05);between the different degree pregnancy induced hypertension,the plasma D-dimer level had significant difference(P<0.05).Conclusion:The plasma D-dimer content of normal pregnancy is increased,and the blood is become hypercoagulable state.Patients with hypertensive disorders in pregnancy have the pathological changes of the coagulation system,and the plasma D-dimer level is higher than that of normal pregnancy.We suggest that we should examine the plasma D-dimer level of patients with hypertension of pregnancy,and understand the existence of thrombotic diseases,to protect the health of mother and infant.%目的:分析正常妊娠与妊娠高血压综合征孕妇血浆D-二聚体水平差异,探讨高血压对妊娠期妇女D-二聚体水平的影响。方法:2010年3月-2013年10月收治妊娠期孕妇128例,按照是否合并高血压分为妊娠期高血压综合征组(60例)和正常妊娠组(68例),另选择同期健康女性70例作为对照组。对比3组血浆D-二聚体水平。结果:妊娠高血压组、正常妊娠组D-二聚体水平显著高于对照组(P<0.05,P<0.01)。妊娠高血压

  20. BMI, Overweight Status and Obesity Adjusted by Various Factors in All Age Groups in the Population of a City in Northeastern Brazil

    Directory of Open Access Journals (Sweden)

    Raquel Patrícia Ataíde Lima

    2015-04-01

    Full Text Available Objective: In Brazil, demographic, socioeconomic and epidemiological changes over time have led to a transition in nutritional standards, resulting in a gradual reduction of malnutrition and an increased prevalence of overweight and obese individuals, similar to the situation in developed countries in previous decades. This study assessed the body mass index (BMI and the prevalence of an overweight status and obesity, adjusted for various factors, in a population in northeastern Brazil including all age groups. Methods: This is a cross-sectional population-based epidemiological study using single sampling procedure composed of levels. Given the heterogeneity of the variable “income” and the relationship between income, prevalence of diseases and nutrition, a stratified sampling on blocks in the first level was used. In this, city districts were classified by income into 10 strata, according to information obtained from IBGE. A systematic sampling was applied on randomly selected blocks in order to choose the residences that would be part of the sample (second level, including 1165 participants from all age groups. Results and Discussion: The prevalence of an overweight status or obesity was adjusted for demographic, socioeconomic and lifestyle variables. When the Chi-square test was applied, a relationship was observed between the prevalence of an overweight status or obesity and the age group, gender, educational level and income of the participants. Regarding lifestyle parameters, only smoking was associated with the prevalence of an overweight status or obesity, in both adults and in the total sample. The results for the following groups were significant (p < 0.05: the age group from 20 to 59 years, when the individual presented an educational level greater than or equal to high school; and the age group ≥ 60 years, when the individual was female. It is noteworthy that educational level and being female were significant in adjusting for

  1. ADJUSTMENT FACTORS AND ADJUSTMENT STRUCTURE

    Institute of Scientific and Technical Information of China (English)

    Tao Benzao

    2003-01-01

    In this paper, adjustment factors J and R put forward by professor Zhou Jiangwen are introduced and the nature of the adjustment factors and their role in evaluating adjustment structure is discussed and proved.

  2. Patterns of Close Relationships and Socioemotional and Academic Adjustment among School-Age Children with Learning Disabilities

    Science.gov (United States)

    Al-Yagon, Michal; Mikulincer, Mario

    2004-01-01

    This study examined patterns of close relationships among school-age children with learning disabilities (LD) as manifested in their attachment style, their self-perceived loneliness, their sense of coherence, and teacher ratings of their academic functioning. In line with resilience theory, this study also aimed to further explore predictors of…

  3. Adjusting to personal and organisational change: views and experiences of female nurses aged 40-60 years.

    Science.gov (United States)

    Gabrielle, Sarah; Jackson, Debra; Mannix, Judy

    2008-01-01

    The Australian nursing workforce is ageing and there is a well-documented shortage of nurses. This global phenomenon means that retaining nurses in the workforce is gaining in importance as older nurses retire and leave nursing. The existing literature reveals deficiencies in knowledge about older nurses as they adapt to ageing often within stressful work environments. The aim of this narrative-based study, informed by feminist principles, was to explore the views and experiences of female registered nurses aged 40-60 years, in acute hospital and community health care settings. In-depth semi-structured interviews of approximately 1 h duration were gathered during late 2004. The transcribed narratives were subjected to thematic analysis. Two major themes were identified. The first theme: "Feeling uncared for" contained three sub-themes--Unsupportive work relationships: "We should be helping each other"; Workplace bullying: "It hurts me and I feel really bad"; and, Stress and burnout: "It's just like being in a pressure cooker all the time". The second major theme identified was "Adapting to ageing: my nursing career". Findings of this research suggest some unmet support needs for older nurses in the workforce which could discourage them from remaining in nursing. The findings highlight a need for further research into the support needs of older nurses. PMID:18780674

  4. D-二聚体定量检测在毛细支气管炎中的应用%Application of quantitative detection of D-dimer in bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    陈学高

    2015-01-01

    Objective To investigate the clinical significance of D-dimer changes in children with bronchiol-itis. Methods 61 children with bronchiolitis were selected and divided into the normal group and the severe group based on their situation, and 11 healthy children were taken as the control group. The levels of D-dimer were detec-ted. Results The level of D-dimer was significantly higher in the study group than in the control group, and it was higher in the severe group than in the normal group (P<0. 01). After the treatment, the level of D-dimer decreased significantly in the severe group (P<0. 01). Conclusion The level of plasma D-dimer can be used to judge the se-verity of bronchiolitis.%目的:探讨毛细支气管炎患儿D-二聚体( D-D)水平变化及临床意义。方法随机选取61例毛细支气管炎住院患儿,根据病情程度分为普通组与重症组,同时选取11例同龄健康婴儿作为正常对照组。检测其血浆D-二聚体水平。结果毛细支气管炎患儿组血浆D-二聚体水平显著高于对照组,重症毛细支气管炎患儿血浆D-二聚体水平显著高于普通患儿组,差异具有统计学意义(P<0.01)。而且重症毛细支气管炎患儿治疗前后血浆D-二聚体水平差异显著,具有统计学意义( P<0.01)。结论血浆D-二聚体水平检测可用于毛细支气管炎病情严重程度的判定。

  5. Establishment of age- and sex-adjusted reference data for hand bone mass and investigation of hand bone loss in patients with rheumatoid arthritis treated in clinical practice

    DEFF Research Database (Denmark)

    Ørnbjerg, Lykke Midtbøll; Østergaard, Mikkel; Jensen, Trine;

    2016-01-01

    BACKGROUND: Rheumatoid arthritis is characterised by progressive joint destruction and loss of periarticular bone mass. Hand bone loss (HBL) has therefore been proposed as an outcome measure for treatment efficacy. A definition of increased HBL adjusted for age- and sex-related bone loss is lacking......: DXR-BMD was measured from hand x-rays in a reference cohort (1485 men/2541 women) without arthritis randomly selected from an urban Danish population. Sex- and age-related HBL/year was estimated. DXR-BMD was measured in rheumatoid arthritis patients (n = 350: at start of TNFI, and ~2 years after TNFI...... increased HBL during TNFI treatment. In the 350 patients, increased HBL during TNFI was associated with time-averaged 28-joint disease activity score (odds ratio 1.69 (95 % Confidence Interval 1.34-2.15)/unit increase, p 

  6. Age and education adjusted normative data and discriminative validity for Rey's Auditory Verbal Learning Test in the elderly Greek population.

    Science.gov (United States)

    Messinis, Lambros; Nasios, Grigorios; Mougias, Antonios; Politis, Antonis; Zampakis, Petros; Tsiamaki, Eirini; Malefaki, Sonia; Gourzis, Phillipos; Papathanasopoulos, Panagiotis

    2016-01-01

    Rey's Auditory Verbal Learning Test (RAVLT) is a widely used neuropsychological test to assess episodic memory. In the present study we sought to establish normative and discriminative validity data for the RAVLT in the elderly population using previously adapted learning lists for the Greek adult population. We administered the test to 258 cognitively healthy elderly participants, aged 60-89 years, and two patient groups (192 with amnestic mild cognitive impairment, aMCI, and 65 with Alzheimer's disease, AD). From the statistical analyses, we found that age and education contributed significantly to most trials of the RAVLT, whereas the influence of gender was not significant. Younger elderly participants with higher education outperformed the older elderly with lower education levels. Moreover, both clinical groups performed significantly worse on most RAVLT trials and composite measures than matched cognitively healthy controls. Furthermore, the AD group performed more poorly than the aMCI group on most RAVLT variables. Receiver operating characteristic (ROC) analysis was used to examine the utility of the RAVLT trials to discriminate cognitively healthy controls from aMCI and AD patients. Area under the curve (AUC), an index of effect size, showed that most of the RAVLT measures (individual and composite) included in this study adequately differentiated between the performance of healthy elders and aMCI/AD patients. We also provide cutoff scores in discriminating cognitively healthy controls from aMCI and AD patients, based on the sensitivity and specificity of the prescribed scores. Moreover, we present age- and education-specific normative data for individual and composite scores for the Greek adapted RAVLT in elderly subjects aged between 60 and 89 years for use in clinical and research settings.

  7. Comorbid Development of Disruptive Behaviors from age 1½ to 5 Years in a Population Birth-Cohort and Association with School Adjustment in First Grade.

    Science.gov (United States)

    Carbonneau, Rene; Boivin, Michel; Brendgen, Mara; Nagin, Daniel; Tremblay, Richard E

    2016-05-01

    Comorbidity is frequent among disruptive behaviors (DB) and leads to mental health problems during adolescence and adulthood. However, the early developmental origins of this comorbidity have so far received little attention. This study investigated the developmental comorbidity of three DB categories during early childhood: hyperactivity-impulsivity, non-compliance, and physical aggression. Joint developmental trajectories of DB were identified based on annual mother interviews from age 1½ to 5 years, in a population-representative birth-cohort (N = 2045). A significant proportion of children (13 % to 21 %, depending on the type of DB) consistently displayed high levels of hyperactivity-impulsivity, non-compliance, or physical aggression from age 1½ to 5 years. Developmental comorbidity was frequent, especially for boys: 10 % of boys and 3.7 % of girls were on a stable trajectory with high levels of symptoms for the three categories of DB. Significant associations were observed between preschool joint-trajectories of DB and indicators of DB and school adjustment assessed by teachers in first grade. Preschoolers who maintained high levels of hyperactivity-impulsivity, non-compliance, and physical aggression, displayed the highest number of DB symptoms in first grade for all categories according to their teacher. They were also among the most disadvantaged of their class for school adjustment indicators. Thus, DB manifestations and developmental comorbidity of DB are highly prevalent in infancy. Early childhood appears to be a critical period to prevent persistent and comorbid DB that leads to impairment at the very beginning of school attendance and to long-term serious health and social adjustment problems. PMID:26311619

  8. Stroke Prevalence, Mortality and Disability-Adjusted Life Years in Children and Youth Aged 0-19 Years

    DEFF Research Database (Denmark)

    Krishnamurthi, Rita V; deVeber, Gabrielle; Feigin, Valery L;

    2015-01-01

    increases in the global prevalence rates of childhood IS, as well as significant decreases in the global death rate and DALYs rate of all strokes in those of age 0-19 years. While prevalence rates for childhood IS and HS decreased significantly in developed countries, a decline was seen only in HS...... stroke care. © 2015 S. Karger AG, Basel.......BACKGROUND: There is increasing recognition of stroke as an important contributor to childhood morbidity and mortality. Current estimates of global childhood stroke burden and its temporal trends are sparse. Accurate and up-to-date estimates of childhood stroke burden are important for planning...

  9. Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis Avaliação dos níveis séricos de D-dímeros entre doentes com urticária crônica, psoríase e urticária vasculite

    OpenAIRE

    Paulo Ricardo Criado; Lidi Che Leon Antinori; Celina Wakisaka Maruta; Vitor Manoel Silva dos Reis

    2013-01-01

    BACKGROUND: It has been demonstrated that neutrophils, eosinophils and monocytes, under appropriated stimulus, may express tissue factor and therefore, activate the extrinsic pathway of coagulation. We performed a transversal and case-control study of patients with chronic urticaria and patients with psoriasis, in our outpatient clinic to evaluate the production of D-dimer. OBJECTIVE: To evaluate D-dimer serum levels in patients with chronic urticaria and its possible correlation with dis...

  10. Convexity Adjustments

    DEFF Research Database (Denmark)

    M. Gaspar, Raquel; Murgoci, Agatha

    2010-01-01

    A convexity adjustment (or convexity correction) in fixed income markets arises when one uses prices of standard (plain vanilla) products plus an adjustment to price nonstandard products. We explain the basic and appealing idea behind the use of convexity adjustments and focus on the situations...

  11. 老年脓毒症患者血浆D-二聚体和降钙素原水平变化∗%The Changes of Plasma Levels of D-dimer and Procalcitonin in Elderly Patients with Sepsis

    Institute of Scientific and Technical Information of China (English)

    杨勇文; 李从荣#

    2015-01-01

    目的::回顾性分析 D-二聚体和降钙素原水平在老年脓毒症患者中的变化。方法:将172例老年脓毒症患者按预后分为生存组(n=115)和死亡组(n=57);采用免疫比浊法和电化学发光法分别检测两组患者入院时血浆 D-二聚体和降钙素原水平,比较血浆 D-二聚体、降钙素原水平和急性生理与慢性健康状况评分(APACHEⅡ评分)的组间差异及其相关性。结果:生存组血浆 D-二聚体和降钙素原水平和 APACHEⅡ评分均低于死亡组(P<0.01);老年脓毒症患者血浆 D-二聚体和降钙素原水平与 APACHEⅡ评分存在明显正相关性(r 分别为0.352、0.234,P <0.05)。结论:不同预后的老年脓毒症患者血浆 D-二聚体和降钙素原水平存在差异,监测这两个生物学指标对老年脓毒症患者的预后具有一定的参考价值。%Objective:To analysis the changes of D-dimer,procalcitonin levels in elderly patients with sepsis. Method:1 72 cases of elderly patients with sepsis were divided into survival group (n=1 1 5)and death group (n=57).When patients admitted to hospital,immune turbidimetric method and electrochemical luminescence method were used respectively to detect the plasma D-dimer and procalcitonin levels.The plasma D-dimer,procalcitonin lev-els and acute physiology and chronic health evaluation (APACHE Ⅱ score)differences between groups and their correlation were analyzed.Results:Survival group of plasma D-dimer and procalcitonin levels and APACHE Ⅱscores were lower than the death group with statistical significance (P <0.01 ).Plasma D-dimer and procalcitonin levels and APACHE Ⅱ scores were significantly positive correlations (r = 0.352,0.234,P < 0.05 ).Conclusion:There were differences in plasma of D-dimer and procalcitonin levels of in the elderly sepsis patients with different prognosis.The two biological indicators had certain reference value for the prognosis of elderly patients with sepsis.

  12. 从scFv噬菌体库分离特异性的人源化抗D-dimer抗体%Isolation of specific humanized anti-D-dimer scFv fragments from scFv phage libraries

    Institute of Scientific and Technical Information of China (English)

    夏红利; 谭最; 陈德杰; 乔建国; 邱仁峰

    2011-01-01

    目的 从scFv(单链Fv)噬菌体抗体库分离出对D-dimer有特异性的人源化单克隆scFv.方法 对Tomlinson scFv噬菌体文库进行3轮淘洗,富集特异性的抗D-dimer抗体并进行ELISA 验证.通过酶联免疫检测和双脱氧终止法基因测序,获取特异性的人源化单克隆抗体.结果 3轮淘洗选择出38个抗D-dimer噬菌体抗体,酶联免疫和基因测序分析后,20个不同的全长单克隆抗D-dimer scFv噬菌体抗体被筛选出来,3轮选择后阳性克隆获取率为100%;分泌性抗体ELISA结果显示单克隆anti-D-dimer噬菌体顺利表达了抗体蛋白;5个A450值较高的单克隆中,3个显示了对D-dimer的高特异性和亲和力.结论 抗体噬菌体展示技术是分离获取人源化特异性anti-D-dimer抗体的高效快速方法.%Objective To isolate specific humanized anti-D-dimer scFv(single chain Fv) antibody from scFv phage libraries. Methods Isolate anti-D-dimer positive clones from Tomlinson I + J phage libraries by three rounds of panuing, then sequence monoclonal genes by bideoxy-mediated chain termination and express soluble scFv antibody; Pick out anti-D-dimer antibodies with high specificity and affinity by ELISA.Results After three rounds of selection from human scFv phage libraries Tomlinson I and J, 38 monclonal specific anti-D-dimer scFv fragments were selected. By polyclonal and monoclonal phage ELISA and gene sequencing, 20 different full-length monoclonal scFv phages were identified, the result of soluble scFv ELISA showed that 20 full-length monoclonal scFv were expressed smoothly. According to the result of soluble scFv ELISA, in 5 scFv antibodies with high value of A450 selected, 3 scFv antibody fragments showed high specific and affinity. Conclusion Antibody phage display was an effective, rapid method to isolate anti-D-dimer antibodies with high specificity and affinity.

  13. 动态监测D-二聚体在产后抢救中的应用价值%The. Applied Value of Dynamic Monitoring the Level of D-dimer in the Patients with Postpartum Hemorrhage

    Institute of Scientific and Technical Information of China (English)

    何卫恒; 周丽英; 吴昂

    2009-01-01

    Objective To dynamic monitor the level of D--dimer after transfusion treatment of postpartum hemorrhage and the possibility of thrombosis. Methods To retrospective analyze and compare of the level of D-dimer of 10 cases with postpartum hemorrhage, while the one in 20 eases of normal confinement in our hospital of year 2008. Results The level of D-dimer in the ease of postpartum hemorrhage was significantly higher than the one in the ease of normal confinement, and this difference indicated important significance(P<0.01).Dynamic monitoring 10 eases of emergency treatment of patients with plasma D-dimer levels with the effective condition improved after treatment and gradually decreased. Conclusion D-dimer is the main mark of secondary fibrinolysis, and the results reflect the function of D-dimer in vascular endothelial injury and blood coagulation, anti-coagulation and fibrinolytie. Furthermore, it has important significance in the understanding of the body's blood coagulation status and the prediction of mierothrombus formation, bleeding tendency, or the occurrence and development of disseminated intravaseular coagulation(DIC), development%目的 通过动态检测产后大出血输血治疗中的D-二聚体水平,以评估疗效及新鲜血栓形成的可能性.方法 回顾性分析2008年本院10例产后大出血抢救中的D-二聚体水平和凝血四项结果,同时检测20例正常分娩产妇的D-二聚体水平作对照分析,并采用t检验进行统计分析.结果 产后大出血抢救中的血浆D-二聚体水平显著高于正常对照组,差异有显著性(P<0.01).动态监测10例抢救患者的血浆D-二聚体水平随有效治疗病情好转后而逐渐降低.结论 D-二聚体是继发性纤溶标志,其检测结果能反映患者的血管内皮损伤及凝血、抗凝血和纤溶功能,对了解机体的血液凝固状态,预测是否有微血栓的形成和出血倾向,预测弥散性血管内凝血(DIC)发生、发展及患者的预后具有重要的临床价值.

  14. D-二聚体检测在2型糖尿病并发症诊断中的应用%D-dimer in the detection of complications of diabetes diagnosis

    Institute of Scientific and Technical Information of China (English)

    彭易清

    2009-01-01

    目的 研究血浆D-二聚体在2型糖尿病相关并发症诊断的价值.方法 将74例糖尿病患者分为无并发症组(45例)、并发症组(29例),同时设健康对照组(46例),采用ELISA法分别测定各组血浆D-二聚体水平并进行比较.结果 糖尿病并发症组D-二聚体水平明显高于健康对照组(P0.05).结论 检测糖尿病D-二聚体是糖尿病并发血管病变的诊断指标之一.严格控制血糖、监测D-二聚体对防治糖尿病并发症有一定意义.%Objective To study the clinical significance of blood plasma D-dimer in diabetes mel-litus patients. Methods Divides into 74 example diabetes group without the complication group (45 examples), the complication group (29examples), and carries on the comparison with the control group 46 examples, uses the ELISA method to determine each group of blood plasma D-direct level separate-ly. Results Diabetes complication group D-dimer level is higher than the control group obviously(P0.05). Conclusion The examination diabetes D-direct is one of diabetes con-current blood vessel pathological change's diagnosis targets. The strict control blood sugar, monitors the D-dimer to prevent and control diabetes complication to have certain significance.

  15. Association of CRP and D-Dimer with secondary pulmonary hypertension in patients with AECOPD%CRP及D-Dimer在慢性阻塞性肺疾病急性加重期继发肺动脉高压中的相关性

    Institute of Scientific and Technical Information of China (English)

    金丛; 黄相增

    2014-01-01

    Objective To explore the clinical significance of C-reaction protein ( CRP ) and D-Dimer levels in patients with acute exacerbation of chronic obstructive pulmonary disease ( AECOPD ) complicated by pulmonary hypertension (PH) and their association with HP. Methods Arterial blood gas and levels of CRP and D-Dimer were detected in 150 patients with AECOPD. Results Levels of CRP, D-Dimer, and PaCO2 were higher but PO2 level was lower in patients with moderate to severe PH than those with mild PH and the control subjects. Levels of CRP and D-Dimer were higher in patients with mild PH than the control subjects. Levels of CRP, D-Dimer, and PCO2 levels had a linear relationship with PASP, while PO2 was negatively correlated with PASP. Levels of CRP and D-Dimer were positively related with PCO2, while were negatively correlated with PO2. Conclusions Levels of CRP and D-Dimer can be used as an indicator for estimating the severity of pulmonary hypertension in patients with AECOPD.%目的:探讨C反应蛋白(CRP)及D-二聚体(D-Dimer)在慢性阻塞性肺疾病急性加重期(AECOPD)合并肺动脉高压( PH )患者中的临床意义及相关性。方法:150例AECOPD患者进行CRP、D-Dimer及动脉血气检测。结果:AECOPD合并中重度PH组患者CRP、D-Dimer、PaCO2水平高于轻度PH组及对照组,(P<0.05),而PaO2水平低于轻度PH组及对照组(P<0.05)。AECOPD合并轻度PH组患者CRP、D-Dimer水平高于对照组(P<0.05)。 CRP、D-Dimer、PaCO2与肺动脉收缩压(PASP)呈正相关;PaO2与PASP呈负相关;CRP、D-Dimer 与 PaCO2呈正相关;CRP、D-Dimer 与 PaO2呈负相关。结论:CRP 及 D-Dimer 水平可作为AECOPD患者判断PH严重程度的指标。

  16. Pulmoner emboli tanısında D-dimer düzeyleri ile ventilasyon/perfüzyon sintigrafisindeki bulgular arasındaki ilişki

    OpenAIRE

    Hasbek, Zekiye; Erselcan, Taner; Gül, Serdar Savaş

    2014-01-01

    Aim. Pulmonary embolism (PE) is a cardiovascular disease that the diagnosis is needed urgent recognition or exclusion, since the PE has high risk of death and anticoagulant treatment starting with suspicion of PE has high risk of bleeding. Ventilation/perfusion(V/P) scintigraphy is one of the widely used tests in suspect of PE. D-dimer is a product of fibrin degradation. However, it is not specific for acute thrombosis. The purpose of this study was to investigate the relation between number ...

  17. Sensitivität des D-Dimers zum Ausschluß venöser thromboembolischer Erkrankungen im klinischen Alltag

    Directory of Open Access Journals (Sweden)

    Lohr G

    2007-01-01

    (falsch negative Rate 1,3 %. Die Sensitivität betrug hier 98,7 %. In unserer Arbeit zeigen sich im Vergleich D-Dimere alleine und Kombination D-Dimertest/KW mit verschiedenen Scoresystemen zwar nicht signifikante Unterschiede in den falsch negativen Ergebnissen, bei allerdings geringer Fallzahl. Die falsch negative Rate von 3,8 % bei alleiniger D-Dimertestung ist bei diesen potentiell tödlichen Erkrankungen hoch. Die Sensitivität und die Sicherheit der Ausschlußdiagnostik kann durch den Einsatz von Scoresystemen in Kombination mit D-Dimertests, die nicht invasiv sind, erhöht werden, und somit eine einfache, leicht durchzuführende und optimale Ergänzung darstellen.

  18. 脊柱关节炎患者D-二聚体和纤维蛋白原检测临床意义初探%Detection and clinical significance of blood of D-Dimer and fibrinogen in spondyloarthritis

    Institute of Scientific and Technical Information of China (English)

    王育凯

    2013-01-01

    Objective To detect the clinical significance of D-Dimer and fibrinogen in the blood of spondyloarthritis (SpA) patients.Methods D-Dimer and fibrinogen of blood were detected among 50 patients with SpA,rheumatoid arthritis (RA),and systemic lupus erythematosus (SLE).further to investigate the relationship of other factors,such as patient global score (PGS),doctor global score (DGS),erythrocyte sedimentation rate (ESR),C-reactvie protein (CRP),platelet (PLT),serum ferritin (SF),and Human Leucocyte Antigen-B27 (HLA-B27).Results The titer of D-Dimer in SpA was significantly lower than that of the RA and SLE group [(535 ±748),(3477 ±4808) and (1285 ±2131) μg/L respectively,P <0.05].The level of fibrinogen in three groups was no significant difference.PGS and DGS was higher in SpA patients with positive D-Dimer and fibrinogen than those with control group (P < 0.05).The values of ESR,CRP and SF in SpA patients with positive D-Dimer and fibrinogen were significantly higher than those in patients with control group.There was positive correlation between D-Dimer and fibrinogen and ESR (r =0.37 and 0.55 respectively,P < 0.01),CRP (r =0.54 and 0.54 respectively,P < 0.01),and DGS (r =0.13 and 0.19 respectively,P<0.01).D-Dimer had positive correlation with PGS (r=0.15,P<0.01).Conclusion The level of D-Dimer and fibrinogen in the blood of SpA patients in increased,and is positively correlated with disease activities.The results indicated that the activation of coagulation-fibrinolytic system may play a role in the pathogenesis of SpA.%目的 探讨检测D-二聚体和纤维蛋白原(Fib)在脊柱关节炎(SpA)患者中的临床意义.方法 比较50例SpA、50例类风湿关节炎(RA)和50例SLE患者血中D-二聚体和Fib水平.并研究其与患者总体评分(PGS)、医生总体评分(DGS)、ESR、CRP、血小板、铁蛋白、HLA-B27等指标的关系.结果 SpA组、RA组、SLE组的血D-二聚体水平分别为(535±748)、(3 477±4 808)和(1 285±2 131

  19. Effects of neurofeedback on the level of D-dimer in patients with cerebral infarction%脑电生物反馈对脑梗死患者D-二聚体的影响

    Institute of Scientific and Technical Information of China (English)

    刘文杰; 胡义奎

    2013-01-01

    目的 探讨超脑电生物反馈对脑梗死患者的纤溶系统指标D-二聚体(D-dimer)的影响. 方法 共选取发病72 h内入院的急性脑梗死患者126例,运用随机数字表法分为脑电生物反馈治疗组(治疗组)62例及常规治疗组(对照组)64例,2组患者均接受神经内科常规药物治疗,治疗组在常规治疗基础上给予脑电生物反馈治疗.所有患者在入院时及治疗2周后进行血浆D-二-聚体的检测及美国国立卫生院卒中量表(NIHSS)评分.结果 经2周治疗后,治疗组有效率(88.7%)明显优于常规治疗组(68.7%,P<0.05);2组患者入院时D-二聚体水平高于阴性对照组(P<0.05),2周后2组D-二聚体水平较入院时降低(P<0.05),且治疗组变化幅度较对照组显著(P<0.05). 结论 脑电生物反馈治疗能下调D-二聚体,对脑梗死患者的神经功能有显著改善作用.%Objective To investigate the effects of neurofeedback on the level of D-dimer in the patients with acute cerebral infarction. Methods All 126 patients with cerebral infarction within the first 72 h from stroke onset were randomly divided into the control group(64 cases) and therapy group(62 cases). All patients received routine treatment, and the patients in therapy group were given additional neurofeedback. In both groups, the plasma level of D-dimer was measured by double antibodies sandwich enzyme linked immunosorbent assay (ELISA) at the time of admission and 2 weeks later. According to National Institute of Health Stroke Scale (NIHSS) ,the effect was evaluated at the time of admission and 2 weeks later. Results The score of NIHSS and the level of D-dimer were significantly decreased after therapy in both groups. The efficacy in therapy group was more significant than that in control group (88. 7% vs 68. 7% ,P < 0. 05). Conclusions Neurofeedbak is effective in treating the acute cerebral infarction by decreasing the level of D-dimer.

  20. Dynamic analysis of plasma NT-ProBNP and D-dimer levels in acute pulmonary embolism%急性肺栓塞血浆NT-ProBNP与D-二聚体水平的动态分析

    Institute of Scientific and Technical Information of China (English)

    白重阳; 吕晓丽; 苏征; 辛欢; 陈颖; 李斌; 张惠中

    2014-01-01

    目的:通过检测急性肺栓塞(APE)患者溶栓前后血浆氨基末端脑钠肽前体(NT-ProBNP)、D-二聚体水平,探讨其变化特点及意义。方法60例疑似APE患者,其中经CT确诊并符合溶栓条件的APE患者40例设为实验组,经CT排除APE患者20例为对照组。测定两组治疗前及实验组溶栓治疗2周后血浆 NT-ProBNP 与D-二聚体水平并进行比较。结果 NT-proBNP检测对早期APE患者的诊断灵敏度为92.3%,特异度为65%;D-二聚体检测对早期APE患者的诊断的灵敏度为100%,特异度为70%;实验组溶栓前血浆NT-ProBNP与D-二聚体水平显著高于对照组,差异有统计学意义(P<0.01)。结论血浆NT-ProBNP与D-二聚体对APE具有重要的临床意义,可为APE患者早期诊断及疗效观察提供依据。%Objective To detect plasma amino-terminal pro-brain natriuretic peptide (NT-ProBNP) ,D-Dimer levels in the pa-tients with acute pulmonary embolism (APE) in order to investigate their change characteristics and significance .Methods Among 60 patients with suspected APE ,40 cases diagnosed by CT and meeting the thrombolytic condition were set as the experimental group and other 20 cases of excluded APE by CT as the control group .Plasma NT-ProBNP and D-dimer before treatment in the two groups and after 2-week thrombolytic therapy in the experimental thrombolysis were detected and compared .Results The diagnos-tic sensitivity of NT-ProBNP for early APE was 92 .3% and the specificity was 65% ,while the diagnostic sensitivity of D-dimer for early APE was 100% and the specificity was 70% ;the plasma NT-ProBNP and D-dimer levels before thrombolysis in the experi-mental group were significantly higher than those in the control group with statistical differences (P<0 .01) .Conclusion Plasma NT-ProBNP and D-dimer has important clinical significance for APE and can provide the basis for the early diagnosis and the cura-tive effect observation of

  1. Adjustment disorder

    Science.gov (United States)

    American Psychiatric Association. Diagnostic and statistical manual of mental disorders . 5th ed. Arlington, VA: American Psychiatric Publishing. 2013. Powell AD. Grief, bereavement, and adjustment disorders. In: Stern TA, Fava ...

  2. Influence of ACE I/D Polymorphism on Circulating Levels of Plasminogen Activator Inhibitor 1, D-Dimer, Ultrasensitive C-Reactive Protein and Transforming Growth Factor β1 in Patients Undergoing Hemodialysis.

    Directory of Open Access Journals (Sweden)

    Sara Santos de Carvalho

    Full Text Available There is substantial evidence that chronic renal and cardiovascular diseases are associated with coagulation disorders, endothelial dysfunction, inflammation and fibrosis. Angiotensin-Converting Enzyme Insertion/Deletion polymorphism (ACE I/D polymorphism has also be linked to cardiovascular diseases. Therefore, this study aimed to compare plasma levels of ultrassensible C-reactive protein (usCRP, PAI-1, D-dimer and TGF-β1 in patients undergoing HD with different ACE I/D polymorphisms.The study was performed in 138 patients at ESRD under hemodialysis therapy for more than six months. The patients were divided into three groups according to the genotype. Genomic DNA was extracted from blood cells (leukocytes. ACE I/D polymorphism was investigated by single polymerase chain reaction (PCR. Plasma levels of D-dimer, PAI-1 and TGF-β1 were measured by enzyme-linked immunosorbent assay (ELISA, and the determination of plasma levels of usCRP was performed by immunonephelometry. Data were analyzed by the software SigmaStat 2.03.Clinical characteristics were similar in patients with these three ACE I/D polymorphisms, except for interdialytic weight gain. I allele could be associated with higher interdialytic weight gain (P = 0.017. Patients genotyped as DD and as ID had significantly higher levels of PAI-1 than those with II genotype. Other laboratory parameters did not significantly differ among the three subgroups (P = 0.033. Despite not reaching statistical significance, plasma levels of usCRP were higher in patients carrying the D allele.ACE I/D polymorphisms could be associated with changes in the regulation of sodium, fibrinolytic system, and possibly, inflammation. Our data showed that high levels of PAI-1 are detected when D allele is present, whereas greater interdialytic gain is associated with the presence of I allele. However, further studies with different experimental designs are necessary to elucidate the mechanisms involved in these

  3. Salary adjustments

    CERN Document Server

    HR Department

    2008-01-01

    In accordance with decisions taken by the Finance Committee and Council in December 2007, salaries are adjusted with effect from 1 January 2008. Scale of basic salaries and scale of stipends paid to fellows (Annex R A 5 and R A 6 respectively): increased by 0.71% with effect from 1 January 2008. As a result of the stability of the Geneva consumer price index, the following elements do not increase: a)\tFamily Allowance, Child Allowance and Infant Allowance (Annex R A 3); b)\tReimbursement of education fees: maximum amounts of reimbursement (Annex R A 4.01) for the academic year 2007/2008. Related adjustments will be applied, wherever applicable, to Paid Associates and Students. As in the past, the actual percentage increase of each salary position may vary, due to the application of a constant step value and rounding effects. Human Resources Department Tel. 73566

  4. Salary adjustments

    CERN Document Server

    HR Department

    2008-01-01

    In accordance with decisions taken by the Finance Committee and Council in December 2007, salaries are adjusted with effect from 1 January 2008. Scale of basic salaries and scale of stipends paid to fellows (Annex R A 5 and R A 6 respectively): increased by 0.71% with effect from 1 January 2008. As a result of the stability of the Geneva consumer price index, following elements do not increase: a) Family Allowance, Child Allowance and Infant Allowance (Annex R A 3). b) Reimbursement of education fees: maximum amounts of reimbursement (Annex R A 4.01) for the academic year 2007/2008. Related adjustments will be implemented, wherever applicable, to Paid Associates and Students. As in the past, the actual percentage increase of each salary position may vary, due to the application of a constant step value and the rounding effects. Human Resources Department Tel. 73566

  5. Research Progress on the Relationship of Coronary Heart Disease and D-dimer,Lipoprotein(a),Fibrinogen%D-二聚体、脂蛋白(a)、纤维蛋白原和冠心病关系研究进展

    Institute of Scientific and Technical Information of China (English)

    龚小鹏

    2012-01-01

    冠心病(CHD)与D-二聚体、脂蛋白(a)、纤维蛋白原(FG)有着密切的关联,CHD患者中D-二聚体、脂蛋白(a)、FG较高,但它们之间相互作用的机制仍不明确.近年来的研究显示,D-二聚体、脂蛋白(a)和FG可能参与CHD的发病过程,因此通过测定D-二聚体、脂蛋白(a)和FG在不同危险程度的CHD患者中的含量,评估它们对于CHD的发生、发展具有重要意义.%Coronary heart disease( CHD)is closely associated with D-dimer,lipoprotein( a)and fibrino-gen( FG),CHD patients have higher levels of D-dimer,lipoprotein( a),fibrinogen while the mechanism of the interaction between them remains unclear. In recent years, studies have shown that D-dimer,lipoprotein ( a )and fibrinogen may be involved in the pathogenesis of coronary heart disease, so by measuring D-dimer, lipoprotein( a )and fibrinogen level in patients with coronary heart disease is of great significance for assessing the genesis and development of CHD.

  6. Clinical study on lysophospholipids acid, D_dimers detection in the prediction of progress and application effect of cerebral apoplexy%溶血磷脂酸、D-二聚体检测预测进展性脑卒中的临床应用研究

    Institute of Scientific and Technical Information of China (English)

    胡红晓

    2014-01-01

    Objective:To study the lysophospholipids acid , D_dimers detection in the prediction of progress and application effect of cerebral apoplexy .Methods:Our hospital in April 2012 to April 2013 were 35 patients with progressive stroke ( research group ) , physical examination, 35 cases (control group) as the research object, research on two groups of objects of D -dimer, lysophosphatide acid level testing and comparison .Results:The group D -dimer level of patients >75 mu g/L, positive;Control the research object of D -dimer level <75 mu g/L, negative;Group patients were lysophospholipids , D -dimer acid average levels were significantly higher than that of control group, P <0.05).Conclusion:D -dimer, lysophosphatide acid was an important molecular markers of early thrombosis in vivo, by detecting D -dimer, lysophosphatide acid levels , could provide effective basis for clinical prediction progress sex stroke .%目的:探讨溶血磷脂酸、D-二聚体检测在预测进展性脑卒中的应用效果。方法:选取我院在2012年4月~2013年4月收治的进展性脑卒中患者35例(研究组)、健康体检者35例(对照组)作为研究对象,对2组研究对象的D-二聚体、溶血磷脂酸水平进行检测、比较。结果:研究组患者的D-二聚体水平均>75μg/L,呈阳性;对照组研究对象的D-二聚体水平均<75μg/L,呈阴性;研究组患者的溶血磷脂酸、D-二聚体平均水平均显著高于对照组,P<0.05。结论:D-二聚体、溶血磷脂酸是体内早期血栓形成的重要分子标志物,通过检测D-二聚体、溶血磷脂酸水平,可为临床预测进展性脑卒中提供有效依据。

  7. D-Dimer plasma levels in patients with coronary artery disease Níveis plasmáticos de Dímero D em pacientes com doença arterial coronariana

    Directory of Open Access Journals (Sweden)

    Luciana M. Lima

    2006-12-01

    Full Text Available We have previously reported that prothrombin fragment 1+2 levels were not associated to the presence or severity of coronary artery disease (CAD and do not provide further information on subjects with CAD diagnosed by angiography. Thus, in the present study another marker of hypercoagulability was evaluated in the same subjects. This study aimed at determining D-Dimer plasma levels in a group of subjects undergoing coronary angiography to establish a likely relation between this parameter and the severity of CAD. D-Dimer plasma levels were determined in 17 subjects with no coronary atheromatosis (controls, 12 subjects with mild/moderate atheromatosis and 28 subjects with severe atheromatosis. No significant differences were observed among the three groups. Data analysis enables an inference on a tendency towards an increase in fibrinolytic activity in patients with atheromatosis, reflected by the increase in D-Dimer concentrations in the severe atheromatosis group in subjects with CAD diagnosed by coronary angiography.Em estudo prévio, os níveis plasmáticos do fragmento 1+2 da protrombina não foram associados com a presença ou com a gravidade da doença arterial coronariana (DAC, não trazendo benefício adicional pelo menos em indivíduos com diagnóstico de DAC estabelecido por angiografia. Desta forma, neste estudo outro marcador de hipercoagulabilidade foi avaliado nos mesmos pacientes. O presente estudo teve como objetivo determinar os níveis plasmáticos do dímero D de um grupo de indivíduos submetidos à angiografia coronariana, buscando estabelecer a possível correlação entre este parâmetro e a gravidade da DAC. Os níveis plasmáticos do dímero D foram determinados em amostras de sangue de 17 indivíduos com ausência de ateromatose nas coronárias (controles, 12 indivíduos apresentando ateromatose leve/moderada e 28 indivíduos apresentando ateromatose grave. Não foram encontradas diferenças estatisticamente

  8. 20 CFR 404.412 - After my benefits are reduced for age when and how will adjustments to that reduction be made?

    Science.gov (United States)

    2010-04-01

    ...'s benefit, any month before attainment of full retirement age for which she or he was not entitled... records to identify when an individual has attained full retirement age and one or more months described... with the month of attainment of full retirement age. In the case of widow's or widower's benefits,...

  9. The Role of Culture in Relational Aggression: Associations with Social-Psychological Adjustment Problems in Japanese and US School-Aged Children

    Science.gov (United States)

    Kawabata, Yoshito; Crick, Nicki R.; Hamaguchi, Yoshikazu

    2010-01-01

    The purpose of this study was (1) to evaluate psychometric properties that assess forms of aggression (i.e., relational and physical aggression) across cultures (i.e., Japan and the United States) and (2) to investigate the role of culture in the associations between forms of aggression and social-psychological adjustment problems such as…

  10. The Social Adjustment In Preschool Age. The Role Of Socio-Emotional Competence And Teacher-Child Relationship Quality On Peer Acceptance

    OpenAIRE

    Sette, Stefania

    2012-01-01

    Little attention has been given to the processes by which the qualities of the teacher–child relationship (e.g., close, dependent, or conflictive) and children’s social behavior are related to young children’s social adjustment in early childhood (Palermo et al., 2007). The present dissertation, divided in three studies, investigated the direct and indirect contribution of children’s individual characteristics, quality of teacher-child relationships, and social behavior in an integrated mo...

  11. Effect of Tongmai Jiangzhi Oral Liquid (通脉降脂口服液) on Serum P-selectin,von Willebrand Factors and D-Dimer in Patients with Atherosclerosis

    Institute of Scientific and Technical Information of China (English)

    沈晓君; 史云菊; 王玲

    2004-01-01

    Objective: To explore the role of cytokines on the pathogenesis of atherosclerosis, and the lectins (Ps), von Willebrand (vWF), and D-dimer (D-D) in atherosclerosis (AS) patients. Methods: Sixtythree AS patients were randomly divided into the treated group ( n = 33, treated with TMJZ, 10 ml each time, three times a day) and the control group (n = 30, treated with Lovastatin, 10 mg, once daily). The levels of serum lipids (enzymatic methods), Ps, vWF, and D-D were measured before and after 8 weeks of treatment. Results: Serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), apo-protein B-100 (apoB-100) were significantly decreased (P<0.05 or P< 0.01) and high-density lipoprotein cholesterol (HDL-C) was significantly raised (P<0.05) after TM JZ treatment. Serum Ps,vWF, and D-D also declined (P<0.05) after treatment. There was no significant difference between the treated and the control groups in these parameters except serum HDL-C level. Conclusion: TMJZ has good therapeutic effect in regulating serum lipids, improving endothelial cell function, inhibiting activation of platelets, and preventing the disturbance of blood coagulation/fibrinolysis function in patients with AS.

  12. 全髋关节置换术后血浆D-二聚体及纤维蛋白降解产物浓度变化特点的临床意义%Total hip arthroplasty plasma D- dimer and fibrin degradation product concentration changes of clinical significance

    Institute of Scientific and Technical Information of China (English)

    周胜虎; 甄平; 郑宁刚; 高明暄; 田琦; 常彦峰; 李旭升

    2013-01-01

    Objective To investigate the total hip arthroplasty D-dimer (DD) and fibrin degradation products (FDPS) concentration and its effect on the dynamic changes of the early diagnosis of deep venous thrombosis (DVT) value. Methods From July 2011 to May 2012 126 cases of hip replacement patients, their data were retrospectively analyzed, including 56 males and 70 females; aged 38 to 92 years, mean 75.6 years old. According to 7 days after lower extremity B-test results, patients were divided into thrombus group of 32 patients, 94 cases of non-thrombotic group . By immune nephelometry were measured on admission, postoperative 1d, 4d, 7d plasma D-dimer and fibrin degradation products (FDPS) concentration, the relevant test results OK statistical analysis, combined with B-test results, analysis comparison of plasma DD, FDPS two detection index and joint detection sensitivity of the results. Results 126 cases of arthroplasty patients with DD and FDPS values increased in varying degrees postoperatively . Different time points after DD and FDPS plasma concentrations were higher than those without DVT patients, the difference was statistically significant (P<0.05). FDPS after 4, 7 days significantly increased (P<0.01). Compared with baseline in both groups at each time point after DD were significantly increased, peaking at 1 day after surgery : no thrombus group (2469.9±508.3) μg/L, thrombosis group (3472.2 ± 690.7)μg/L (P<0.01);FDPS increased significantly after 4, 7 days and 7 days values increased significantly compared with the value of 4 days:Non-thrombosis group (3673.4±480.7)μg/L, thrombosis group.Conclusion Patients with total hip arthroplasty plasma D-dimer and fibrin degradation product concentration for dynamic monitoring of early diagnosis of DVT has important value.%目的:探讨全髋关节置换术后血浆D-二聚体(DD)及纤维蛋白降解产物(FDPs)浓度的动态变化特点及其对早期诊断下肢深静脉血栓

  13. Neonatal mortality risk associated with preterm birth in East Africa, adjusted by weight for gestational age: individual participant level meta-analysis.

    Directory of Open Access Journals (Sweden)

    Tanya Marchant

    Full Text Available BACKGROUND: Low birth weight and prematurity are amongst the strongest predictors of neonatal death. However, the extent to which they act independently is poorly understood. Our objective was to estimate the neonatal mortality risk associated with preterm birth when stratified by weight for gestational age in the high mortality setting of East Africa. METHODS AND FINDINGS: Members and collaborators of the Malaria and the MARCH Centers, at the London School of Hygiene & Tropical Medicine, were contacted and protocols reviewed for East African studies that measured (1 birth weight, (2 gestational age at birth using antenatal ultrasound or neonatal assessment, and (3 neonatal mortality. Ten datasets were identified and four met the inclusion criteria. The four datasets (from Uganda, Kenya, and two from Tanzania contained 5,727 births recorded between 1999-2010. 4,843 births had complete outcome data and were included in an individual participant level meta-analysis. 99% of 445 low birth weight (< 2,500 g babies were either preterm (< 37 weeks gestation or small for gestational age (below tenth percentile of weight for gestational age. 52% of 87 neonatal deaths occurred in preterm or small for gestational age babies. Babies born < 34 weeks gestation had the highest odds of death compared to term babies (odds ratio [OR] 58.7 [95% CI 28.4-121.4], with little difference when stratified by weight for gestational age. Babies born 34-36 weeks gestation with appropriate weight for gestational age had just three times the likelihood of neonatal death compared to babies born term, (OR 3.2 [95% CI 1.0-10.7], but the likelihood for babies born 34-36 weeks who were also small for gestational age was 20 times higher (OR 19.8 [95% CI 8.3-47.4]. Only 1% of babies were born moderately premature and small for gestational age, but this group suffered 8% of deaths. Individual level data on newborns are scarce in East Africa; potential biases arising due to the non

  14. Adjustment factors of birth weight and four postnatal weights for type of birth and rearing, sex of lambs and dam age

    OpenAIRE

    Subandriyo; D. W. Vogt

    1995-01-01

    Many factors contribute to variation in lamb weights. Factors such as age of lamb, sex, type of birth and rearing, and ewe age at lambing obscure genetic differences among lambs. Variation associated with these factors make selection for increased weight less effective. To improve selection response, selection must be based on genotypic rather than environmentally induced superiority. It is well-documented that corrections for classifiable sources of variation render selection and culling mor...

  15. 慢性支气管炎合并肺炎患者血浆中D-二聚体检测的临床意义%Clinical significance of plasma D-dimer detection in chronic bronchitis complicated with pneumonia patients

    Institute of Scientific and Technical Information of China (English)

    刘海波

    2015-01-01

    目的:探讨慢性支气管炎合并肺炎患者血浆中D-二聚体检测的临床意义。方法慢性支气管炎急性发作合并肺炎患者64例和肺栓塞患者30例,对其D-二聚体进行快速定量测定。结果慢性支气管炎急性发作合并肺炎患者和肺栓塞患者D-二聚体差异无统计学意义(P>0.05)。结论检测D-二聚体为判断慢性支气管炎是否合并肺部感染有一定的意义,且有助于判断炎症的轻重及病情变化。%Objective To investigate clinical significance of plasma D-dimer detection in chronic bronchitis complicated with pneumonia patients.Methods There were 64 cases of chronic bronchitis acute attack complicated with pneumonia and 30 cases of pulmonary embolism. Rapid quantitative determination was made for D-dimer in all patients.Results The difference of D-dimer had no statistical significance between chronic bronchitis acute attack complicated with pneumonia patients and pulmonary embolism patients (P>0.05). Conclusion Detection of D-dimer provides certain value for judging whether chronic bronchitis is complicated with pulmonary infection. This method is also helpful to judging status of inflammation and disease.

  16. Imaging of deep venous thrombosis in patients using a radiolabelled anti-D-dimer Fab' fragment ({sup 99m}Tc-DI-DD3B6/22-80B3): results of a phase I trial

    Energy Technology Data Exchange (ETDEWEB)

    Macfarlane, David [University of Queensland, School of Medicine, Brisbane (Australia); Socrates, Angelides; Larcos, George [University of Sydney, Department of Medicine, Sydney (Australia)]|[Westmead Hospital, Department of Nuclear Medicine and Ultrasound, Westmead (Australia)]|[Westmead Hospital, Centre for Biomedical Imaging and Research, Westmead (Australia); Eisenberg, Paul [Amgen Inc, Thousand Oaks, CA (United States); Roach, Paul [University of Sydney, Department of Medicine, Sydney (Australia)]|[Royal North Shore Hospital, Nuclear Medicine, St. Leonards (Australia); Gerometta, Michael [Agen Biomedical Pty Ltd, Brisbane (Australia); Smart, Richard; Tsui, Wendy [St. George Hospital, Nuclear Medicine Department, Sydney (Australia)]|[University of New South Wales, Department of Medicine, Sydney (Australia); Scott, Andrew M. [Austin Hospital, Centre for PET, Melbourne (Australia)]|[Ludwig Institute, Melbourne (Australia)

    2009-02-15

    {sup 99m}Tc-DI-DD3B6/22-80B3 (ThromboView registered, hereafter abbreviated to {sup 99m}Tc-DI-80B3 Fab') is a radiolabelled humanised monoclonal Fab' fragment with affinity and specificity for D-dimer domains of cross-linked fibrin. Detection of thromboembolic events has been demonstrated in canine models. The study objectives were evaluation of safety and characterisation of biodistribution, immunogenicity and pharmacokinetic profile of increasing doses of {sup 99m}Tc-DI-80B3 Fab' in subjects with acute lower-limb DVT. Twenty-six patients with acute lower limb DVT were enrolled. Of these, 21 received a single intravenous dose of 0.5 mg (n = 6), 1.0 mg (n = 9) or 2 mg (n = 6) {sup 99m}Tc-DI-80B3 Fab'. Blood and urine samples and gamma camera images were collected to 24 h after administration for pharmacokinetic and dosimetry analysis. Vital signs, electrocardiography, hematological and biochemical data and human anti-human antibody (HAHA) levels were monitored for up to 30 days following administration. Patients were assigned to either planar or single photon emission computed tomographic (SPECT) imaging of the thorax at 4 h following injection. Thirty-five adverse events were reported in 15 of the 21 subjects. Those deemed possibly related to administration of {sup 99m}Tc-DI-80B3 Fab' included mild hypertension, mild elevation of LD (lactate dehydrogenase) and moderate elevation of ALT (alanine transaminase). HAHA assays remained negative. Pharmacokinetics and organ dosimetry were comparable to prior normal volunteer data. Localisation of Thromboview registered to sites of known thrombus was evident as early as 30 min post-injection. In subjects with acute DVT, {sup 99m}Tc-DI-80B3 Fab' was well tolerated with favourable characteristics for the detection of acute venous thrombosis. (orig.)

  17. School Achievements, Behavioural Adjustments and Health at Nine Years of Age in a Population of Infants Who Were Born Preterm or Required Prolonged Mechanical Ventilation.

    Science.gov (United States)

    Mohay, Heather; And Others

    The prevalence of subtle handicapping conditions, such as learning disabilities, behavior problems, and recurrent illness, in a population of 88 high-risk infants was investigated when the children reached 9 years of age. Infants had had birthweights of less than 1500 grams or had required prolonged mechanical ventilation in the neonatal period.…

  18. Can they recover? An assessment of adult adjustment problems among males in the abstainer, recovery, life-course persistent, and adolescence-limited pathways followed up to age 56 in the Cambridge Study in Delinquent Development.

    Science.gov (United States)

    Jennings, Wesley G; Rocque, Michael; Fox, Bryanna Hahn; Piquero, Alex R; Farrington, David P

    2016-05-01

    Much research has examined Moffitt's developmental taxonomy, focusing almost exclusively on the distinction between life-course persistent and adolescence-limited offenders. Of interest, a handful of studies have identified a group of individuals whose early childhood years were marked by extensive antisocial behavior but who seemed to recover and desist (at least from severe offending) in adolescence and early adulthood. We use data from the Cambridge Study in Delinquent Development to examine the adult adjustment outcomes of different groups of offenders, including a recoveries group, in late middle adulthood, offering the most comprehensive investigation of this particular group to date. Findings indicate that abstainers comprise the largest group of males followed by adolescence-limited offenders, recoveries, and life-course persistent offenders. Furthermore, the results reveal that a host of adult adjustment problems measured at ages 32 and 48 in a number of life-course domains are differentially distributed across these four offender groups. In addition, the recoveries and life-course persistent offenders often show the greatest number of adult adjustment problems relative to the adolescence-limited offenders and abstainers.

  19. Establishing Age-Adjusted Reference Ranges for Iris-Related Parameters in Open Angle Eyes with Anterior Segment Optical Coherence Tomography.

    Directory of Open Access Journals (Sweden)

    Jeffrey R Peterson

    Full Text Available Define criteria for iris-related parameters in an adult open angle population as measured with swept source Fourier domain anterior segment optical coherence tomography (ASOCT.Ninety-eight eyes of 98 participants with open angles were included and stratified into 5 age groups (18-35, 36-45, 46-55, 56-65, and 66-79 years. ASOCT scans with 3D mode angle analysis were taken with the CASIA SS-1000 (Tomey Corporation, Nagoya, Japan and analyzed using the Anterior Chamber Analysis and Interpretation software. Anterior iris surface length (AISL, length of scleral spur landmark (SSL to pupillary margin (SSL-to-PM, iris contour ratio (ICR = AISL/SSL-to-PM, pupil radius, radius of iris centroid (RICe, and iris volume were measured. Outcome variables were summarized for all eyes and age groups, and mean values among age groups were compared using one-way analysis of variance. Stepwise regression analysis was used to investigate demographic and ocular characteristic factors that affected each iris-related parameter.Mean (±SD values were 2.24 mm (±0.46, 4.06 mm (±0.27, 3.65 mm (±0.48, 4.16 mm (±0.47, 1.14 (±0.04, 1.51 mm2 (±0.23, and 38.42 μL (±4.91 for pupillary radius, RICe, SSL-to-PM, AISL, ICR, iris cross-sectional area, and iris volume, respectively. Both pupillary radius (P = 0.002 and RICe (P = 0.027 decreased with age, while SSL-to-PM (P = 0.002 and AISL increased with age (P = 0.001. ICR (P = 0.54 and iris volume (P = 0.49 were not affected by age.This study establishes reference values for iris-related parameters in an adult open angle population, which will be useful for future studies examining the role of iris changes in pathologic states.

  20. Physiology and biochemistry of leaf bleaching in prematurely aging maple (Acer saccharinum L.) trees. II. Functional and molecular adjustment of PSII.

    OpenAIRE

    Lepeduš, Hrvoje; Begović, Lidija; Mlinarić, Selma; Šimić, Domagoj; Štolfa, Ivna; Parađiković, Nada; Užarević, Zvonimir; Jurković, Vlatka; Cesar, Vera

    2011-01-01

    In the present study we aimed to investigate physiological and molecular mechanisms of photosynthetic performance decline in prematurely aged bleached leaves of silver maple (Acer saccharinum L.) trees. We used in vivo chlorophyll a fluorescence measurement to analyze changes in PSII photochemistry, relative abundance of photosynthetic proteins (D1, LHCII, Cytf and Rubisco LSU), relations between chlorophylls and their precursor protochlorophyllide as well as elemental composition of the l...

  1. The Value of D-dimer and Fibrinogen in the Diagnosis of Coronary Artery Disease%血浆D-二聚体和纤维蛋白原检测在冠心病临床诊断中的价值

    Institute of Scientific and Technical Information of China (English)

    陈高科

    2014-01-01

    Objective:To study the significance of detection of plasma D-dimer and fibrinogen in the diagnosis of coronary artery disease.Method:The level of plasma D-dimer and fibrinogen of 108 patients with different types of coronary artery diseases and 62 health people from May 2011 to Dec 2012 were detected. The results of plasma D-dimer and fibrinogen were analyzed.Result:The levels of plasma D-dimer and fibrinogen of acute myocardial infarction(AMI) patients were higher than those of healthy people,unstable angina pectoris(UAP) and stable angina pectoris(SAP) patients(P0.05).Conclusion:The detection of plasma D-dimer and fibrinogen contribute to the diagnosis and typing of coronary heart disease.%目的:研究血浆D-二聚体和纤维蛋白原检测在冠心病临床诊断中的意义。方法:对2011年5月-2012年12月在笔者所在医院就诊的108例不同类型的冠心病患者及62例正常体检者的血浆D-二聚体及纤维蛋白原水平进行检测,分析D-二聚体及纤维蛋白原检测结果在冠心病临床诊断中的意义。结果:急性心肌梗死患者的D-二聚体及纤维蛋白原水平高于正常体检者、不稳定型心绞痛患者和稳定型心绞痛组患者,差异均有统计学意义(P0.05)。结论:临床血浆D-二聚体及纤维蛋白原水平的检测有助于冠心病分型诊断。

  2. 血浆D-二聚体及纤维蛋白原在非小细胞肺癌患者围术期监测中的应用价值%Value of plasma D-dimer,fibrinogen levels monitoring in non-small cell lung cancer patients in perioperative period

    Institute of Scientific and Technical Information of China (English)

    江吕泉; 高坤祥; 郑建; 陈建; 吴昊; 陈林松

    2013-01-01

    Objective Bleeding or thrombotic diseases are easily to be found in non - small cell lung cancer ( NSCLC ) patients, because the equilibrium of their coagulation system might be disturbed due to tumor burden or surgical injury. In the study, we studied the value of plasma D - dimer and fibrinogen levels monitoring in patients with non - small cell lung cancer before and after surgery. Methods The plasma D - dimer and fibrinogen levels were measured in 254 patients with non - small cell lung cancer and 52 patients with benign lung tumor, and then we followed up to record the D - dimer and fibrinogen levels change in postoperative patients. Results The plasma levels of D - dimer and fibrinogen in non - small cell lung cancer patients were found to be significantly higher than those in patients with benign lung tumor ( P < 0. 01). Significant differences in D - dimer and fibrinogen levels were found among different stages of non - small cell lung cancer ( P < 0. 01 ) , which suggested that coagulation and fibrinolysis dysfunction in patients with non - small cell lung cancer aggravated along with the progression of disease. The D - dimer and fibrinogen levels kept at a high level or rose suddenly after a transient decrease in 15 patients who had thrombotic diseases after operation. Conclusions Monitoring the plasma D - dimer and fibrinogen levels in patients with non - small cell lung cancer before and after operation helps find out those who have high risk of thrombotic diseases and preventing thrombtic disease after operation. It also helps us to strive for early prevention, early diagnosis,early treatment,nd to improve the prognosis of the patients.%目的 探讨血浆D-二聚体及纤维蛋白原(fibrinogen,FIB)在非小细胞肺癌患者手术前、后监测中的应用价值.方法 测定254例非小细胞肺癌患者和52例肺部良性肿瘤患者血浆D-二聚体及FIB水平,对其术后D-二聚体及FIB变化进行随访监测.结果 非小细胞肺癌组

  3. Correlative Analysis of the Relationships and Differences on D-dimer, Fibrinogen and Antithrombin Ⅲ Between Varied Clinical Periods of Cerebral Infarction%D-D、Fb和AT-Ⅲ在脑梗死不同时期的变化及相关性分析

    Institute of Scientific and Technical Information of China (English)

    徐威香; 武蓉珍; 胡晓蕾

    2012-01-01

    目的:探讨血浆D-二聚体(D-D)、纤维蛋白原(Fb)和抗凝血酶Ⅲ(AT-Ⅲ)在脑梗死(CI)不同时期的变化及其临床意义.方法:根据临床特征,对260例CI患者进行分组,其中CI急性期组80例、进展期组41例、非进展期组65例、康复期组74例;90例体检健康者为正常对照组.采用SYSMEX CA7000血凝仪分别检测其血浆D-D、Fb和AT-Ⅲ水平.结果:CI急性期、进展期、非进展期患者D-D、Fb含量均明显高于正常对照组(P<0.01),AT-Ⅲ低于正常对照组(P<0.01);脑梗死组中,D-D与AT-Ⅲ呈负相关(P<0.01),D-D与Fb呈正相关(P<0.01),AT-Ⅲ与Fb无相关性.结论:CI患者D-D、Fb、AT-Ⅲ变化显著,D-D升高伴随AT-Ⅲ含量降低,提示D-D、Fb、AT-Ⅲ共同参与了梗死发生发展的病理生理过程,可作为CI临床危险分级和病情监测的指标.%Objective To investigate the differences and its clinical significance of D-dimer, fibrinogen and antithrombin Ⅲ between varied clinical periods of cerebral infarction( CI). Methods 328 CI patients were rolled into the study, and they were divided into four groups due to their different clinical periods as follows: group acute period (80) , group progressing(41) , group non-pro-gressing(65) , group convalescence(74). And, 90 healthy volunteers were rolled into the normal control group. Their plasma D-dimer, fibrinogen and antithrombin HI were detected on SYSMEX CA7000 automatic coagulation analyzer. Results D-dimer and fibrinogen of CI patients in the acute, progressing and non-progressing periods were significantly higher (P <0.01) than those of healthy volunteers, while antithrombin Ⅲ of them was significantly lower (P<0.01) than that of healthy volunteers. In CI patients, D-dimer correlated negatively with antithrombin Ⅲ, while positively with fibrinogen. No significant relationship was observed between antithrombin Ⅲ and fibrinogen. ConclUSin D-dimer, fibrinogen and antithrombin Ⅲ of CI patients varied significantly

  4. End criteria for reaching maximal oxygen uptake must be strict and adjusted to sex and age: a cross-sectional study.

    Directory of Open Access Journals (Sweden)

    Elisabeth Edvardsen

    Full Text Available OBJECTIVE: To describe different end criteria for reaching maximal oxygen uptake (VO2max during a continuous graded exercise test on the treadmill, and to explore the manner by which different end criteria have an impact on the magnitude of the VO2max result. METHODS: A sample of 861 individuals (390 women aged 20-85 years performed an exercise test on a treadmill until exhaustion. Gas exchange, heart rate, blood lactate concentration and Borg Scale6-20 rating were measured, and the impact of different end criteria on VO2max was studied;VO2 leveling off, maximal heart rate (HRmax, different levels of respiratory exchange ratio (RER, and postexercise blood lactate concentration. RESULTS: Eight hundred and four healthy participants (93% fulfilled the exercise test until voluntary exhaustion. There were no sex-related differences in HRmax, RER, or Borg Scale rating, whereas blood lactate concentration was 18% lower in women (P<0.001. Forty-two percent of the participants achieved a plateau in VO2; these individuals had 5% higher ventilation (P = 0.033, 4% higher RER (P<0.001, and 5% higher blood lactate concentration (P = 0.047 compared with participants who did not reach a VO2 plateau. When using RER ≥1.15 or blood lactate concentration ≥8.0 mmol•L(-1, VO2max was 4% (P = 0.012 and 10% greater (P<0.001, respectively. A blood lactate concentration ≥8.0 mmol•L(-1 excluded 63% of the participants in the 50-85-year-old cohort. CONCLUSIONS: A range of typical end criteria are presented in a random sample of subjects aged 20-85 years. The choice of end criteria will have an impact on the number of the participants as well as the VO2max outcome. Suggestions for new recommendations are given.

  5. Adjustments and Depression

    Medline Plus

    Full Text Available ... to my SCI? How do I deal with depression and adjustment to my SCI? ☷ ▾ Page contents The ... the moment you are injured. Understanding adjustment and depression Adjustment to paralysis is a process of changing ...

  6. Cognitive control adjustments in healthy older and younger adults: Conflict adaptation, the error-related negativity (ERN), and evidence of generalized decline with age.

    Science.gov (United States)

    Larson, Michael J; Clayson, Peter E; Keith, Cierra M; Hunt, Isaac J; Hedges, Dawson W; Nielsen, Brent L; Call, Vaughn R A

    2016-03-01

    Older adults display alterations in neural reflections of conflict-related processing. We examined response times (RTs), error rates, and event-related potential (ERP; N2 and P3 components) indices of conflict adaptation (i.e., congruency sequence effects) a cognitive control process wherein previous-trial congruency influences current-trial performance, along with post-error slowing, correct-related negativity (CRN), error-related negativity (ERN) and error positivity (Pe) amplitudes in 65 healthy older adults and 94 healthy younger adults. Older adults showed generalized slowing, had decreased post-error slowing, and committed more errors than younger adults. Both older and younger adults showed conflict adaptation effects; magnitude of conflict adaptation did not differ by age. N2 amplitudes were similar between groups; younger, but not older, adults showed conflict adaptation effects for P3 component amplitudes. CRN and Pe, but not ERN, amplitudes differed between groups. Data support generalized declines in cognitive control processes in older adults without specific deficits in conflict adaptation.

  7. Prognostic value of the age-adjusted International Prognostic Index in chemosensitive recurrent or refractory non-Hodgkin's lymphomas treated with high-dose BEAM therapy and autologous stem cell transplantation.

    Science.gov (United States)

    Jabbour, E; Peslin, N; Arnaud, P; Ferme, C; Carde, P; Vantelon, J M; Bocaccio, C; Bourhis, J H; Koscielny, S; Ribrag, V

    2005-06-01

    High-dose therapy (HDT) is now recommended for patients under 60 years of age with chemosensitive relapsed aggressive non-Hodgkin's lymphoma. However, approximately half of these patients will be cured by HDT. Prognostic factors are needed to predict which patients with chemosensitive lymphoma to second-line therapy could benefit from HDT. We retrospectively investigated the prognostic value of the widely used age-adjusted International Prognostic Index (AA-IPI) calculated at the time of relapse (35 patients) or just before second-line salvage therapy for primary refractory disease (5 patients). The median age was 51 years (range 18-64 years). Thirty-six patients had diffuse large B-cell lymphoma. Salvage cytoreductive therapy before HDT was DHAP/ESHAP (cytarabine, cysplatin, etoposide, steroids) in 17 patients, VIM3-Ara-c/MAMI (high-dose cytarabine, ifosfamide, methyl-gag, amsacrine) in 17 patients, CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) or reinforced CHOP in 4 patients, high-dose cyclophosphamide and etoposide in 2 patients. The HDT regimen consisted of BEAM (carmusine, cytarabine, etoposide, melphalan) in all cases. Eleven patients were in partial remission and 29 in complete remission at the time of HDT. Ten patients had an IPI >1, 16 had relapsed early (6 months after first-line chemotherapy) (P=1), but the AA-IPI >1 was associated with a poor outcome (P=0.03). In conclusion, the AA-IPI could have a prognostic value in patients with chemosensitive recurrent lymphoma treated with BEAM HDT.

  8. 联检NSE、CYFRA21-1、D-二聚体、Fib在肺癌患者中的临床意义%Clinical significance of the combined determination of NSE, CYFRA21-1, D-Dimer, Fibrinogen for the patients with lung cancer

    Institute of Scientific and Technical Information of China (English)

    谢颖; 贾张军; 张云生

    2014-01-01

    Objective To discuss the clinical significance of the combined determination of NSE,CYFRA21-1, D-Dimer, Fibrinogen for lung cancer patients. Methods The levels of serum NSE and CYFRA21-1 were detected by electrochemical analysis in 256 lung cancer patients, 200 patients with benign lung diseases and 200 health subjects. The levels of plasma D-Dimer and Fibrinogen were detected by immunoturbidimetric assays. The relationship of NSE, CYFRA21-1, D-Dimer and Fibrinogen levels with the clinical stages of lung cancer was analyzed by statistics. Results The levels of NSE, CYFRA21-1, D-Dimer and Fibrinogen in patients with lung cancer were significantly higher than those in patients with benign lung diseases and healthy controls(PCYFRA21-1 > D-Dimer > Fibrinogen.CYFRA21-1 showed the highest sensitivity(69.0%) in squamous cellcarcinoma, and NSE showed the highest sensitivity(68.4%%) in smal celllung cancer. The combined determination of NSE, CYFRA21-1, D-Dimer, Fibrinogen might significantly improve the sensitivity for the diagnosis of lung cancer. The combined determination of NSE,CYFRA21-1, D-Dimer, Fibrinogen showed the highest sensitivity(89.8%).NSE,CYFRA21-1, D-Dimer, Fibrinogen were positively related to the clinical stages of lung cancer. With the increasing of clinical stages, the levels of NSE,CYFRA21-1, D-Dimer, Fibrinogen in Ⅲ/Ⅳ stage were significantly higher than those in Ⅰ/Ⅱ stage(correlation coefficie nt(r)=0.315,0.425,0.669,0.523,). Conclusions The combined determination of NSE, CYFRA21-1, D-Dimer, Fibrinogen has an important clinical significance in the clinical diagnosis, differentiation, monitor and clinical stage of lung cancer.%联合检测神经元特异烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)、D-二聚体(D-D)、Fib(纤维蛋白原),探讨其在肺癌患者中的临床意义。方法肺癌组(256例)、肺良性疾病组(200例)和正常对照组(200例)的血清NSE、CYFRA21-1水平采用电化学发光分析法检测,血

  9. Clinical diagnostic value of serum ferritin united with plasma D-Dimer test in patients with cerebral infarction%血清铁蛋白联合D-二聚体检测对脑梗死患者的诊断价值

    Institute of Scientific and Technical Information of China (English)

    陈勇坚

    2011-01-01

    Objective: To investigate the clinical significance of serum ferritin and plasma D-dimer in diagnosing cerebral infarction. Methods: To select 215 cases of cerebral infarction patients in our hospital from 2008 to 2010 as treatment group, 215 cases of normal people as control group, and to compare serum ferritin and D-dimer in two groups. Then compare serum ferritin and D-dimer results of live cerebral infarction patients before and after urokinase thrombolysis therapy.Results: 6 cases died during the therapy among the 215 patients, 1 patients died of cerebral hernia, 3 cases died of lung infection, 2 cases died of cerebral infarction with myocardial infarction. The differences of D-dimer between the two groups had statistical significance (t=7.325, P<0.01). There were significant differences between the normal and patients in serum ferritin as well (t=7.923, P<0.01). And D-dimer of live cerebral infarction patients increase obviously after thrombolysis therapy (t=8.301, P<0.01), the serum ferritin decreased obviously (t=9.627, P<0.01). Conclusion: The test results of serum ferritin and D-dimer are sensitive to diagnose cerebral infarction, and closely related with the recovery and prognosis.%目的:研究脑梗死患者血清内D-二聚体和铁蛋白含量对脑梗死诊断的意义.方法:选择我院2008~2010年脑梗死患者215例为治疗组,正常门诊体检者215例为对照组,行血清内D-二聚体和铁蛋白检测比较,尿激酶溶栓后再次检测存活的209例脑梗死患者溶栓前后体内D-二聚体和铁蛋白含量.结果:治疗组中,有6例在研究过程中死亡,1例死于脑疝,3例死于肺部感染,2例死于脑梗死合并下壁心肌梗死.正常人与脑梗死患者D-二聚体含量比较差异具有高度统计学意义(t=7.325,P<0.01);正常人与脑梗死患者血清含铁蛋白比较,差异有高度统计学意义(t=7.923,P<0.01).尿激酶溶栓后,治疗组所有存活病例的血清D-二聚

  10. Levels of plasma D-dimer, activated coagulation factor Ⅶ and Ⅻ in patients with chronic urticaria%慢性荨麻疹患者血浆D二聚体、活化凝血因子Ⅶ及活化凝血因子Ⅻ水平的研究

    Institute of Scientific and Technical Information of China (English)

    王朵勤; 唐慧; 沈燕芸; 徐金华

    2015-01-01

    目的 探讨血浆D二聚体、活化凝血因子Ⅶ(FⅦa)及活化凝血因子Ⅻ(FⅫa)在慢性荨麻疹(CU)患者中的表达及其与CU发病的关系.方法 对50例CU患者及50例健康对照用干式免疫散射色谱法检测血浆D二聚体水平,用酶联免疫吸附法检测FⅦa及FⅫa的水平,并结合患者病情严重程度情况进行分析.对43例CU患者自体血浆皮肤试验(APST)及41例CU患者作自体血清皮肤试验(ASST)结果与其血浆D二聚体水平进行比较.结果 CU患者血浆中D二聚体及FⅦa的水平均明显高于健康对照组(P<0.05),前者升高水平与病情严重程度呈正相关(P<0.05);CU患者FⅫa水平与健康对照组比较,差异无统计学意义(P>0.05).APST(+)患者的D二聚体水平明显高于APST(-)患者(P<0.05),而ASST(+)患者D二聚体水平与ASST(-)患者比较,差异无统计学意义(P>0.05).结论 凝血机制与CU相关,外源性凝血途径起着作用,针对凝血机制的研究对于CU的病情评估和临床治疗具有一定的意义.%Objective To measure the levels of plasma D-dimer,activated coagulation factor Ⅶ (FⅦa) and activated clotting factor Ⅻ (FⅫa) in patients with chronic urticaria (CU),and to investigate their relationship with the occurrence of CU.Methods Venous blood samples were collected from 50 patients with CU and 50 healthy human controls.Dry-column immune scattering chromatography was performed to detect the plasma level of D-dimer,and enzyme-linked immunosorbent assay (ELISA) to measure the levels of FⅦa and FⅫa.In addition,autologous plasma skin test (APST) was conducted in 43 patients with CU,and autologous serum skin test (ASST) in 41 patients with CU.A correlation analysis was carried out between the above three parameters and disease severity as well as between the results of APST and ASST and plasma level of D-dimer.Results The levels of plasma D-dimer and F Ⅶa were significantly higher in patients with CU than in healthy

  11. Clinical significance on changes of platelet aggregation test, von Willebrand factor,antithrombin and D-dimer assayin acute cerebral infarction patients%急性脑梗死患者血小板聚集功能、血管性血友病因子、抗凝血酶及 D-二聚体测定的临床意义

    Institute of Scientific and Technical Information of China (English)

    叶青跃; 程鹏飞; 周有利; 饶汉武; 黄承芳; 周立

    2015-01-01

    目的:探讨急性脑梗死患者血小板聚集功能( PAgT)、血管性血友病因子( vWF)、抗凝血酶( AT)和D-二聚体( D-dimer)水平变化及临床意义。方法选用相应的方法和仪器测定112例脑梗死及80例健康对照者血(浆) PAgT、vWF、AT和D-dimer水平变化,同时对部分患者进行治疗前、后的对比分析。结果脑梗死患者血中PAgT、vWF、D-dimer等指标均明显高于健康对照组,AT活性较对照组显著降低,差异有统计学意义(P<0.05或P<0.01)。选取经治疗效果明显好转的78例脑梗死患者,出院前取空腹静脉血测定PAgT、vWF、AT、D-dimer等指标,并与治疗前对照,结果治疗后PAgT、vWF、D-dimer降低,AT活性升高,差异有统计学意义(P<0.05或P<0.01)。结论脑梗死患者体内存在明显的凝血及纤溶功能异常,与血管内皮损伤、血小板聚集功能增强、凝血及纤溶功能亢进、抗凝功能降低等多因素有关。 PAgT、vWF、AT、D-dimer可以作为脑梗死患者诊断、治疗监测和预后判断的参考指标。%Objective To evaluate the clinical signification of coagulation ,anti-coagulation and fibrinolysis indexes i.e.platelet aggrega-tion test(PAgT),von Willebrand factor(vWF),antithrombin(AT),D-dimer in acute cerebral infarction patients.Methods vWF was as-sayed using ELISA method,AT was determined by chromogenic substances assay,and Latex enhanced immune turbidimetry for D-dimer. vWF,AT and D-dimer all the parameters were finished by SysmexCA-7000 automated blood coagulation analyzer.PAgT was measured sim-ultaneously using a whole-blood Lumi-Aggregometer by CHRMNO-LOG platelet aggregation apparatus.Results PAgT, vWF, D-dimer were significantly higher in acute cerebral infarction patients group,compared with those in the control group(P<0.05 or P<0.01). while AT was significantly lower(P<0.05).After effective treatment,PAgT,vWF,AT,D-dimer Indicators are all

  12. Effect of Age on the Hemostatic Function in Patients with Degenerative Diseases of the Large Joints

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    Igor L. Shlykov, PhD¹, ScD¹

    2013-06-01

    Full Text Available Background: Aging is associated with an increased hypercoagulable state. Degenerative diseases of the large joints are also accompanied by increased coagulation activity. We investigated the effect of age on the hemostatic function in patients with osteoarthritis. Material and Methods: The study included 192 patients with osteoarthritis admitted to the clinic for primary hip or knee arthroplasty. The patients were categorized into 5 age groups: the age group under 40 years, the 41–to-50 -year age group, the 51–to-60-year age group, the 61-to-70- year age group, and the age group over 70 years. The general blood clotting tests, platelet number, fibrinogen, antithrombin, protein C, TAT, D-dimer, vonWillebrand factor (vWF, PAI-1, ß-thromboglobulin were determined. Results: Among patients with osteoarthritis, the antithrombin III level significantly decreased by the age of 50; however, above the age of 60 there was a distinct decrease in platelet count, and over the age of 70 the activity of the extrinsic coagulation pathway and the plasminogen level dropped significantly. TAT and D-dimer levels were elevated in most of the patients. Conclusion: The decrease in platelet count coupled with the activity of the extrinsic coagulation pathway in elderly osteoarthritic patients may increase blood loss during total arthroplasty; also, the drop in the anticoagulant and fibrinolytic potential may play a negative role in strengthening the prothrombotic state during the postoperative period.

  13. Plasma D-dimer levels in breast cancer patients correlate with axillary lymph node status%血浆D-二聚体水平与乳腺癌腋窝淋巴结转移的相关性研究

    Institute of Scientific and Technical Information of China (English)

    柴源; 王娟娟; 刘斌

    2015-01-01

    Objective:The purpose of this study is to explore the relationship between plasma D-dimer level and axillary lymph node metastasis of breast cancer, and to provide the basis for predicting axillary lymph node metastasis. Methods:73 cases of breast cancer (breast cancer group), 36 cases of benign breast disease (benign breast disease group) and 50 cases of healthy women (normal control) were collected. Plasma D-dimer levels of the three groups were detected. Histopathologic variables (tumor size, pathological type, lymph node metastasis, number of lymph node metastasis, etc.) were classified and analyzed systematically. Results:Plasma D-dimer levels in breast cancer patients are higher than those in benign breast disease group and normal control group, and the differences are statistically signiifcant (P0.05). Plasma D-dimer levels in the positive axillary lymph node metastasis group are higher than the negative axillary lymph node metastasis group, and the differences are statistically signiifcant (P0.05);腋窝淋巴结转移阳性患者D–二聚体水平高于腋窝淋巴结转移阴性患者,差异有统计学意义(P<0.01);肿瘤大小、病理类型、血浆D–二聚体水平与腋窝淋巴结转移个数显著相关(P<0.01);原发肿瘤的病理类型、血浆D–二聚体水平是腋窝淋巴结转移的危险因素(OR =7.464、6.470);血浆D–二聚体水平诊断乳腺癌腋窝淋巴结转移时的ROC曲线下面积(area under concentration-time,AUC)为0.689,以0.455μg/mL为最佳诊断分界点,灵敏度为52.3%,特异度为86.2%。结论:血浆D–二聚体水平与乳腺癌腋窝淋巴结转移状态及转移个数有关,其对判断乳腺癌腋窝淋巴结转移状态有一定临床价值。

  14. 降钙素原与D-二聚体在评估急诊脓毒症患者病情及预后的研究%Clinical significance of procalcitonin and D-dimer in evaluation of condition and prognosis of sepsis patients in emergency department

    Institute of Scientific and Technical Information of China (English)

    张娙; 董静莲; 王书亮

    2015-01-01

    OBJECTIVE To define the value of procalcitonin and D-dimer in the evaluation of illness condition of the sepsis patients in emergency department and in the predication of prognosis so as to provide guidance for clinical treatment of the sepsis patients.METHODS By means of prospective case-control survey,the concentrations of procalcitonin and D-dimer were determined within 24 hours after the patients were confirmed as the sepsis,the A-PACHEⅡ scoring was performed,the relationship between the D-dimer combined with procalcitonin and the se-verity of sepsis was observed,the patients were divided into the survival group and the death group on the basis of observation endpoint,which was set by the clinical death or survival;the ROC cure was employed to analyze the ability of D-dimer combined with procalcitonin in prediction of the prognosis of the sepsis patients.RESULTS The severer the illness condition of the sepsis patients,the higher the contents of procalcitonin and D-dimer were (P<0.05);the concentration of the procalcitonin and D-dimer of the death group was significantly higher than that of the survival group (P<0.05).With the death set as the final cutoff point,the areas under the ROC curve in predi-cating the mortality of the sepsis patients by procalcitonin and D-dimer were 0.779 and 0.730,respectively.The sensitivity and specificity of procalcitonin in predication of adverse prognosis were respectively 78.6% and 72.7%when the concentration was 7.1 ng/ml;the sensitivity and specificity of D-dimer in predication of adverse progno-sis of the sepsis patients were respectively 78.6% and 65.5% when the concentration was 2.75 mg/L. CONCLUSION Procalcitonin and D-dimer can not only effectively assess the illness condition of the sepsis patients but also predict the prognosis of the patients.%目的:明确降钙素原及D-二聚体在评估急诊脓毒症患者病情以及预测患者预后的能力,以期掌握脓毒症患者病情并指导临床工作。方

  15. Avaliação do dímero D (D-Di na doença hipertensiva específica da gravidez (DHEG D-dimer plasma levels assessment in preeclampsia

    Directory of Open Access Journals (Sweden)

    Luci Maria Sant'Ana Dusse

    2003-09-01

    Full Text Available A doença hipertensiva específica da gravidez (DHEG, na sua forma pura, caracteriza-se pelo aparecimento, em grávida normotensa, após a vigésima semana de gestação, da tríade sintomática: hipertensão, proteinúria e edema. A DHEG está associada a vasoconstrição generalizada, anormalidades da coagulação e deposição de fibrina na microcirculação da placenta. A fibrina compromete a perfusão adequada da placenta, contribuindo para a prematuridade, o baixo peso fetal e a mortalidade neonatal. Os dímeros D (D-Di constituem os menores fragmentos dos produtos de degradação da fibrina (pdf e são produzidos após a lise, pela plasmina, da ligação cruzada da fibrina. Níveis plasmáticos aumentados de D-Di indicam tanto uma exacerbação da formação de fibrina como um aumento da ação da plasmina. O presente trabalho teve por objetivo avaliar e comparar os níveis plasmáticos de D-Di, obtido por Elisa (Stago em gestantes-controle (n = 26, gestantes com DHEG nas formas leve e moderada (n = 23 e gestantes com DHEG na forma grave (n = 20, visando a investigar a possível utilização desse marcador laboratorial para diagnóstico e/ou prognóstico da doença. As médias e os desvios padrões obtidos para os três grupos avaliados foram 1.146,6 ± 311,2; 1.060,3 ± 259,2 e 1.497,8 ± 435,3ng/ml, respectivamente. A análise estatística das médias dos resultados obtidos revelou um aumento significativo de D-Di plasmático no grupo com DHEG grave, comparando-se aos grupos com DHEG leve/moderada (p Preeclampsia is associated to a generalized vasoconstriction, clot abnormalities and fibrin deposition within placenta microcirculation. The presence of fibrin hampers the placenta perfusion contributing to prematurity, fetal low weight and neonates' mortality. D-Dimers (D-Di are the products of degradation of cross-linked fibrin by plasmin. Increased plasma levels of D-Di may indicate either an exacerbated fibrin formation or an increase

  16. Ergonomically Adjustable School Furniture for Male Students

    Science.gov (United States)

    Al-Saleh, Khalid S.; Ramadan, Mohamed Z.; Al-Ashaikh, Riyad A.

    2013-01-01

    The need for adjustability in school furniture, in order to accommodate the variation in anthropometric measures of different genders, cultures and ages is becoming increasingly important. Four chair-table combinations, different in dimensions, with adjustable chair seating heights and table heights were designed, manufactured and distributed to…

  17. RETIRO LABORAL Y AJUSTE A LA JUBILACIÓN DE HOMBRES Y MUJERES EN LA MEDIANA EDAD (WORK RETIREMENT AND ADJUSTMENT TO RETIREMENT OF MEN AND WOMEN IN THE MIDDLE-AGED

    Directory of Open Access Journals (Sweden)

    Cruz Meléndez Roxana

    2011-04-01

    Full Text Available Resumen:En este artículo se presentan los resultados de una investigación aplicada cuyo objeto de estudio fue un grupo de hombres exfuncionarios y mujeres exfuncionarias del área administrativa de la Universidad de Costa Rica (UCR que se encuentran en la etapa de vida denominada “la mediana edad” y que enfrentan el proceso trabajo-retiro laboral. El estudio consistió en identificar los principales factores que inciden en el retiro laboral a una edad más temprana; la viviencia del proceso, el ajuste a la jubilación y sus implicaciones a nivel personal y social. La información recopilada se obtuvo a partir de la técnica “la entrevista fenomenológica” concebida como una exploración profunda que proporciona datos de gran valor conceptual y humana; en ella, tanto la persona que entrevista como la entrevistada mantienen un compromiso para que la búsqueda de la información sea dentro de una relación empática. Partiendo de lo subjetivo por su historia de vida al mandato social por lo roles asignados y asumidos por la población en estudio. Los resultados obtenidos indican que pareciera que la valoración que cada uno de los participantes hace de su rol laboral y el significado del trabajo en sus vidas es determinante en el proceso de retiro laboral y su ajuste al rol de persona jubilada.Abstract: This article presents the results of applied research study that was aimed at a group of men and women, former administrative staff of the University of Costa Rica that are in the stage of life called middle age and facing work-retirement process work. The study consist in identify the main factors affecting the removal from work at a younger age, the experiencing process, adjustment to retirement and its implications for personal and social level. Information collected was obtained from the technique "the phenomenological interview “conceived as a deep exploration that provides valuable data conceptual and human, in her interview both

  18. Annual Adjustment Factors

    Data.gov (United States)

    Department of Housing and Urban Development — The Department of Housing and Urban Development establishes the rent adjustment factors - called Annual Adjustment Factors (AAFs) - on the basis of Consumer Price...

  19. Adjustments and Depression

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    Full Text Available ... depression and adjustment to my SCI? How do I deal with depression and adjustment to my SCI? ☷ ▾ ... following an SCI? What are the secondary conditions? I have no health insurance, what are my options? ...

  20. Adjustments and Depression

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    Full Text Available ... course an adjustment period as you navigate your new normal. The most important point to remember is ... to rebuild one's identity and to find a new balance in relationships. The stages of adjustment can ...

  1. Prognostic values of heart-type fatty acid-binding protein and D-dimer level in plasma in acute pulmonary embolism patients%心肌型脂肪酸结合蛋白联合血浆D-二聚体对肺栓塞预后评估的临床意义

    Institute of Scientific and Technical Information of China (English)

    陶琳; 杨毅

    2015-01-01

    ObjectiveTo evaluate the clinical value of heart-type fatty acid-binding protein (H-FABP) and D-dimer in assessing the prognosis of acute pulmonary embolism (APE). MethodsTotaly 120 APE patients were hospitalized from January 2011 to December 2014 and enroled in this study. The plasma H-FABP and D-dimer level were measured by enzyme-linked immunosorbent assay. The APE patients were divided three groups including low-risk, middle-risk and high-risk group by European heart association new guidelines. According to the clinical prognosis, the APE patients were divided into survival and death group. The H-FABP and D-dimer level in different groups and the relationship with the prognosis were assessed.ResultsWith the increased severity in patients, the H-FABP and D-dimer level were significantly elevated (P<0.05); the H-FABP and D-dimer level were significantly higher in death group as compared with survival group (P<0.05). The H-FABP and D-dimer level were positively correlated (r=0.693,P=0.000). ROC curves analysis results showed that the area under curve of H-FABP was 0.845 (95%CI: 0.752-0.918), and optimal operating point (OOP) was 8.65 µg/L, which had 81.24% sensitivity and 84.14% specificity; ACU of D-dimer was 0.832 (95%CI: 0.728-0.899), and OOP was 1.25 mg/L, which had 83.72% sensitivity and 82.65% specificity.Conclusion The H-FABP and D-dimer can effectively assess severity and prognosis of APE patients, meanwhile, it provide an objective basis for the clinical individual treatment and reducing the mortality rate of APE patients.%目的:探讨心肌型脂肪酸结合蛋白(H-FABP )联合血浆 D-二聚体在评价急性肺栓塞(APE)患者预后中的临床价值。方法选取本院2011年1月至2014年12月确诊的APE患者120例为研究对象,采用酶联免疫吸附法分别测定外周血H-FABP及D-二聚体浓度。根据病情严重程度将APE患者分为低危组、中危组及高危组;根据临床转归,分为存活组和死亡组

  2. Correlation of plasma D-dimer, T lymphocyte subsets, CRP level with Apgar score of neonates in pregnant women with pregnancy-induced hypertension during perinatal period%妊高征孕妇围生期血浆D-二聚体、T细胞亚群及CRP水平与胎儿Apgar评分的相关性

    Institute of Scientific and Technical Information of China (English)

    钟晓红

    2014-01-01

    Objective It is to explore the correlation of plasma D -dimer ( D-D) , T lymphocyte subsets , CRP level with Apgar score of neonates in pregnant women with pregnancy-induced hypertension ( PIH) during perinatal period .Methods 120 pregnant women with PIH were selected as observation group , and 60 healthy pregnant women were selected as control group . Plasma D-D, CD4 +and CD8 +T cell lymphocyte subsets and CRP level of the two groups were detected before and 3d after delivery , and Apgar scores of neonates were recorded after delivery .By applying Pearson correlation analysis , the correlation of plasma D-dimer, T lymphocyte subsets proportion , CRP level and Apgar score of neonates was analyzed .Besides, the correlation of D-dimer, CD4+/CD8 +, CRP index, and Apgar score of neonates was analyzed by multiple logistic regression analysis.Results There was no statistical difference in plasma D -D, CD4+/CD8 +and CRP before and 3d after delivery in control group (P>0.05), while observation group’s plasma D-D and CRP decreased (P<0.05), and CD4 +/CD8 +in-creased (P<0.05).By comparison, D-dimer, CRP, and CD4 +/CD8 +before and 3d after delivery in observation group were all higher than those in control group (P<0.05).By Pearson correlation, it showed that D -dimer, CD4 +/CD8+, CRP and Apgar score of neonates were both negative correlation with each other (P<0.05).By multiple logistic regression a-nalysis, D-dimer and CD4 +/CD8 +are independent forecast factors for Apgar score of neonates (OR=0.673, P=0.032;OR=0.543, P=0.026).Conclusion Plasma D-dimer, T lymphocyte subsets and CRP in pregnant women with PIH during perinatal period have clinical value for assessment of Apgar score of neonates .%目的:探讨妊娠高血压综合征孕妇围生期血浆D-二聚体( D-dimer )、T细胞亚群、C反应蛋白( CRP)与胎儿Apgar评分的相关性。方法选取妊高征孕妇120例设为观察组;另选取同期孕检的健康孕妇60例设为对照组。检测2

  3. 依达拉奉对急性脑梗死患者超敏C-反应蛋白及D-二聚体的影响%Effects of Edaravone on the levels of hs-CRP and D-dimer in Patients with Acute Cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    杜金明; 闫宗廷

    2010-01-01

    目的 探讨依达拉奉对急性脑梗死患者血清超敏C-反应蛋白(hs-CRP)、D-二聚体的影响及临床疗效.方法 86例急性脑梗死患者随机分为两组,即常规治疗组和治疗组,治疗组在常规治疗基础上给予依达拉奉30 mg每天2次静脉点滴,连用14 d.治疗前后测定血清hs-CRP、D-二聚体的变化并用中国卒中量表(Chinese stroke scale,CSS)及巴氏指数(Barthel index,BI)评定.结果 两组患者hs-CRP和D-二聚体均下降,治疗组明显低于常规治疗组(P<0.05).治疗后两组CSS及BI评分指数较治疗前均明显增加,治疗组评分高于常规治疗组(P<0.05).结论 依达拉奉可降低急性脑梗死患者hs-CRP、D-二聚体的水平,有益于患者神经功能的恢复.%Objective To investigate the effects of edaravone on the levels of high sensitivity C-reactive protein(hs-CRP) and D-dimer in patients with acute ischemic cerebral infarction. Methods A total of 86 patients with acute ischemic cerebral infarction were randomly divided and assigned into therapy group and control group. The control group was given a routine treatment of acute ischemic stroke. The therapy group was treated with edaravone in addition to the routine treatment. hs-CRP and D-dimer were measured before and after treatment. Barthel index(BI) and Chinese stroke Scale(CSS) of two groups were assessed before treatment and after treatment. Results The levels of hs-CRP and D-dimer were deceased after treatment. After the start of edaravone ,the levels of hs-CRP and D-dimer of therapy group were significantly lower than those of control group(P <0.05). The scores of CSS and BI of two groups improved after treatment,and scores of CSS and BI of the therapy group were better than those of the control group(P< 0.05). Conclusion Edaravone could decrease the levels of hs-CRP and D-dimer and is beneficial to improve neurofunctional recovery.

  4. 极低出生体重儿童学龄期的行为适应分析%Analysis of behavioral adjustment in school-aged children born with very low birth weight

    Institute of Scientific and Technical Information of China (English)

    曾小璐; 钟敏泉; 岑超群; 邹小兵; 杨杰; 钟向明

    2013-01-01

    [Objective] To evaluate behavioral adjustment and its influential factors among school-aged children born with very low birth weight(VLBW). [Method] The BASICS Behavioral Adjustment Scale was used to investigate 235 very low birth weight children and 396 normal birth weight(NBW) children who studied in mainstream schools, parents of the children completed the questionaire. [Results] A total of 570 out of 631 questionaires were completed, with a response rate of 90. 3%. Scores for VLBW group in dimension of achievement, self-relations, internal state and total scores were significantly higher than those of the NBW group (respectively 3. 06±0. 93,3. 62 ± 0. 88,4. 11 ± 1. 18 and 3. 19 ± 0. 71 vs 2. 29 ± 0. 85,2. 27 ± 0. 78,2. 45 ± 0. 86 and 2. 31 ± 0. 75,P all<0. 05). Multiple regression analysis showed that higer family economics status and main caregiver education level were predictors of better behavioral adjustment among the VLBW group. While those with neonatal intracranial hemorrhage and higer doses of corticosteroid had worse behavioral adjustment.[conclusion] VLBW children have increased behavior problems, early evaluation and intervention is recommended.%[目的]评估极低出生体重(very low birth weight,VLBW)儿童学龄期行为适应状况并探讨相关的影响因素. [方法]采用BASICS行为适应量表对235名就读主流学校的极低出生体重儿童和396名正常出生体重儿童的家长进行问卷调查. [结果]调查的631个家庭中570个家庭完成问卷,应答率90.3%.极低出生体重儿童组成就[(3.06±0.93)分]、自我关系[(3.62±0.88)分]、内在状态[(4.11±1.18)分]得分及行为适应总分[(3.19±0.71)分]高于正常出生体重儿童组,分别为[(2.29±0.85)分],[(2.27±0.78)分],[(2.45±0.86)分]和[(2.31±0.75)分],差异有统计学意义(P<0.05).多元线性回归分析结果显示,家庭收入高、主要管教者受教育程度高的VLBW儿童行为适应较好,新生儿期患颅内出血

  5. Predictive value of D-dimer quantitative determination on postpartum hemorrhage with hypertensive disorder in pregnancy%D-二聚体定量检测对妊娠期高血压疾病患者产后出血的预测价值

    Institute of Scientific and Technical Information of China (English)

    陈佩芬; 李林娜; 陈小燕; 翁美卿; 陈伟忠; 黄桂花

    2014-01-01

    Objective To investigate the predictive value of D-dimer quantitative determination on postpartum hemorrhage with hypertensive disorders in pregnancy patients .Methods One hundred and fifty cases with hypertensive disorders in pregnancy admitted to Chaozhou Hospital from January 2013 to December 2013 were retrospectively analyzed .D-dimer data of all the 150 patients were collected at the 24 hours before delivery .The patients were divided into postpartum hemorrhage group and control group .The correlation between the D-dimer measurement and a loss of blood in the postpartum period was analyzed by one-way ANOVA, and the accuracy of D-dimer predictive variables of postpartum hemorrhage was analyzed by ROC curves .Results Twenty-eight cases had postpartum hemorrhage , and the incidence rate was 18.67% ( 28/150 ) . The average value of D-dimer was ( 9.56 ±11.97 ) mg/L in the postpartum hemorrhage group, while the average value of D-dimer was (1.96 ±1.06) mg/L in the control group, with a significant difference (F=48.61, P<0.01).The area under the ROC curve was 0.848 (95% CI:0.766-0.930), standard error was 0.042.The optimal threshold was 2.26 mg/L, whose specificity, sensitivity and Youden index were 66.4%, 92.9% and 0.593,respectively.Conclusion Quantitative determination of D-dimer has a significant role in predicting postpartum hemorrhage on hypertensive disorders in pregnancy patients , the optimal threshold is 2.26 mg/L.%目的:探讨D-二聚体定量检测对妊娠期高血压疾病患者产后出血的预测价值。方法潮州市潮州医院妇产科2013年1月至2013年12月收治150例妊娠期高血压疾病患者,对其分娩前24 h内D-二聚体进行定量测定,并准确计量其分娩24 h内出血量,依出血量将其分为产后出血组及对照组。单因素方差分析其分娩前24 h内D-二聚体测量值与分娩后24 h内出血量的相关性,以ROC曲线分析其对妊娠期高血压疾病患者产后出血的预测截

  6. Heparin and normal saline solutions for measurement of central venous pressure in elderly patients with elevated D-dimer levels%肝素生理盐水用于D-二聚体升高老年患者中心静脉测压研究

    Institute of Scientific and Technical Information of China (English)

    赵陈英; 陈华; 李威

    2012-01-01

    Objective To solve the problem of catheter blockage developed after measurement of central venous pressure (CVI) in elderly patients with elevated D-dimer levels. Methods Seventy-four elderly patients with elevated D-dimer levels were divided into a control group (n = 34) and an observation group (n = 40) receiving either normal saline or 125 U/mL of heparin and normal saline solutions for CVI measurement. Results Compared with the control group, the observation group achieved less blockage of catheters, higher planned extubation, and longer indwelling time of catheters (P0. 05). Conclusion Measurement of central venous pressure in elderly patients with elevated D-dimer levels by using 125 U/mL of heparin and normal saline solutions, can reduce blockage of catheters.%目的 解决D-二聚体升高老年患者行中心静脉测压后易出现深静脉导管堵塞的问题.方法 将74例D-二聚体升高老年患者分为对照组34例、观察组40例,对照组采用生理盐水行中心静脉测压,观察组采用125 U/mL肝素生理盐水行中心静脉测压.结果 观察组堵管发生率低于对照组,计划拔管的比例高于对照组,置管时间长于对照组(均P<0.01).观察组未发生出血征象,APTT值测压前后比较,差异无统计学意义(P>0.05).结论采用125 U/mL肝素生理盐水对D-二聚体升高老年患者进行中心静脉测压,可降低测压后深静脉导管堵塞发生率,有利于静脉途径的治疗与护理.

  7. Repatriation Adjustment: Literature Review

    Directory of Open Access Journals (Sweden)

    Gamze Arman

    2009-12-01

    Full Text Available Expatriation is a widely studied area of research in work and organizational psychology. After expatriates accomplish their missions in host countries, they return to their countries and this process is called repatriation. Adjustment constitutes a crucial part in repatriation research. In the present literature review, research about repatriation adjustment was reviewed with the aim of defining the whole picture in this phenomenon. Present research was classified on the basis of a theoretical model of repatriation adjustment. Basic frame consisted of antecedents, adjustment, outcomes as main variables and personal characteristics/coping strategies and organizational strategies as moderating variables.

  8. 乙型肝炎后肝硬化患者凝血功能和血浆D-二聚体水平与Child-Pugh肝功能分级的关系分析%Changes in the Levels of D-dimer and CoagulationFactor in Patients with Liver Cirrhosis

    Institute of Scientific and Technical Information of China (English)

    胡晓; 程超; 冯立民

    2013-01-01

    目的 了解不同临床分级的乙型肝炎后肝硬化患者凝血功能和血浆D-二聚体的变化及临床意义.方法 选取浙江大学医学院附属第一医院传染病科2012年1月~7月住院的乙型肝炎后肝硬化患者90例,所有患者按Child-Pugh肝功能分级标准相应分为Child A,Child B和Child C三级.健康对照组为同期在该院体检的87例健康成人,检测乙型肝炎后肝硬化患者组和健康体检者组的D-二聚体,PT,APTT,Fbg和TT并比较分析,同时观察这些指标与Child-Pugh肝功能分级和腹腔积液的关系.结果 90例乙型肝炎后肝硬化患者血浆D-二聚体,PT,APTT和TT显著高于健康对照组,Fbg则显著低于健康对照组,差异有统计学意义(P0.05).结论 血浆D-二聚体及常规凝血功能的检测对了解肝硬化患者有无纤溶亢进和高凝状态有着重要的意义,有利于临床指导治疗和判断预后.腹腔积液可能是肝硬化患者D-二聚体增高的重要因素.%Objective To explore the clinical significance of detecting D-dimer,prothrombin time (PT) ,actived partial throm-boplatin time(APTT) , fibrinogen(Fbg) and thrombin time(TT) in the patients with liver cirrhosis.Methods 90 cases of liver cirrhosis patients and 87 healthy persons were detected in plasma coagulation factor and the observation of these coagulation index and liver function Child-Pugh classification of the relationship.Results The plasma levels of D-dimer, PT, APTT and TT were higher and the concentration of Fbg was lower in patients with liver cirrhosis than healthy persons (P <0.01).There were significant difference among three groups of Child-Pugh classification.The plasma levels of D-dimer, prothrombin time (PT),actived partial thromboplatm time (APTT) and thrombin time(TT) had significant difference between the groups of seroperitoneum and without seroperitoneum (P<0.01).Conclusion The detection of D-dimer, PT, APTT, Fbg and TT can reflect the severity of liver cirhosis

  9. D-二聚体和凝血4项检测在孕妇产前检查中的临床价值分析%The clinical value analysis of D-Dimer and cruor detection in antenatal examination for pregnantwomen

    Institute of Scientific and Technical Information of China (English)

    邹庆红

    2013-01-01

    目的 探讨D二聚体和凝血4项检测在孕妇产前检查中的临床价值,提高妊娠高血压综合征孕妇分娩的安全性.方法 2011年8月~2012年5月,收集正常晚期妊娠妇女50例(晚孕正常组)、晚期妊娠合并妊娠高血压综合征妇女50例(晚孕妊高征组)和门诊体检非妊娠健康妇女50例(对照组),检测D-二聚体、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)和纤维蛋白原(FIB).结果 晚孕妊高征组血清D-二聚体水平最高,对照组最低,差异有统计学意义(p<0.05).晚孕妊高征组PT和APTT水平最低,FIB水平最高,对照组PT和APTT水平最高,FIB水平最低,3组之间差异有统计学意义(P<0.05);3组间TT水平比较,差异无统计学意义(P>0.05).结论 正常妊娠妇女及妊娠高血压综合征妇女血液均处于高凝状态,产前检测D二聚体和凝血4项水平,有助于防止孕妇在分娩过程中发生血栓性疾病或弥漫性血管内凝血,减少产科意外的发生,可以作为产前筛查的主要指标.%Objective To investigate D-Dimer and cruor detection in antenatal examination for pregnant women, and improve the safety of pregnancy-induced hypertension pregnant woman. Methods From August 2011 to May 2012,researchers collected 50 cases of normal late pregnancy women (late pregnancy normal group) , 50 cases of iate pregnancy with pregnancy-induced hypertension women (late pregnancy with pregnancy-induced hypertension group) and 50 cases of non pregnancy healthy women (control group) , detected d-dimer, prothrombin time (PT) , activated part thromboplastin time (APTT) , thrombin time (TT) and fibrinogen ( FIB). Results The D-Dimer level of late pregnancy with pregnancy-induced hypertension group is the highest, and which of the control group is minimum, the differences indicated statistical significance (P 0. 05). Conclusion Normal pregnancy women and pregnancy-induced hypertension women are at a high cruor

  10. Benchmarking judgmentally adjusted forecasts

    NARCIS (Netherlands)

    Ph.H.B.F. Franses (Philip Hans); L.P. de Bruijn (Bert)

    2015-01-01

    markdownabstractMany publicly available macroeconomic forecasts are judgmentally-adjusted model-based forecasts. In practice usually only a single final forecast is available, and not the underlying econometric model, nor are the size and reason for adjustment known. Hence, the relative weights give

  11. ADJUSTABLE CHIP HOLDER

    DEFF Research Database (Denmark)

    2009-01-01

    An adjustable microchip holder for holding a microchip is provided having a plurality of displaceable interconnection pads for connecting the connection holes of a microchip with one or more external devices or equipment. The adjustable microchip holder can fit different sizes of microchips...

  12. The Value of Clinical Examination of C-reactive Protein and D-dimer in Patients with Acute Leukemia and Infection%C反应蛋白和D-二聚体对急性白血病伴感染患者的临床检查价值

    Institute of Scientific and Technical Information of China (English)

    林少芳; 罗志敏

    2014-01-01

    目的:探讨C反应蛋白和D-二聚体对急性白血病伴感染患者的临床检查价值。方法选取该院血液科2011年1月—2013年12月诊断为急性白血病的住院病人,诊断为有感染的患者定义为感染组40例;诊断为弥漫性血管内凝血的患者为弥漫性血管内凝血组40例;同时有感染与弥漫性血管内凝血的患者归为感染+弥漫性血管内凝血组40例。测取各组C反应蛋白和D-二聚体数值。结果感染组、弥漫性血管内凝血组及感染+弥漫性血管内凝血组C反应蛋白和D-二聚体分别为[(42.8依10.5)mg/L、(0.8依0.3)μg/L;(16.5依5.8)mg/L、(1.5依0.6)μg/L;(88.7依21.7)mg/L、(6.8依1.7)μg/L],C反应蛋白和D-二聚体以联合组最高,弥漫性血管内凝血组最低,三组的差异有统计学意义(P<0.05);以C反应蛋白[(<10 mg/L)、(10≤,<100 mg/L)、(≥100 mg/L)]进行分层,CRP≥100 mg/L的人群中,发生DIC比例及血中D-二聚体值最高,而C反应蛋白<10 mg/L的人群中,发生DIC比例及血中D-二聚体值最低,差异有统计学意义(P<0.05)。结论该研究认为急性白血病病人普遍存在感染和异常凝血,可以C反应蛋白和D-二聚体作为检测指标,判断患者是否有发生弥漫性血管内凝血与感染的风险。%Objective To evaluate the value of clinical examination of C-reactive protein and D-dimer in acute leukemia patients with infection. Methods The inpatients diagnosed with acute leukemia in the Department of Hematology of our hospital were se-lected. Those acute leukemia patients complicated by infection were set as the infection group(40 cases), those complicated by dis-seminated intravascular coagulation(DIC) were set as the disseminated intravascular coagulation group(40 cases), and those compli-cated by infection and DIC were set as the infection and disseminated intravascular coagulation group(40 cases). And the values of C-reactive protein and D-dimer

  13. Change of pregnancy-associated protein A,urinary transferrin, D-dimer in patients with hypertension in pregnancy%妊娠相关蛋白 A、尿转铁蛋白、D-二聚体在妊娠期高血压病患者中的变化

    Institute of Scientific and Technical Information of China (English)

    张丽岩; 刘艳庚; 颜媛

    2015-01-01

    Objective To observe the significance of pregnancy-associated protein A (PAPP-A ), urinary transferrin,D-dimer in patients with hypertension in pregnancy and their correlation.Methods The study enrolled 120 patients with pregnancy-induced hypertension syndrome as pregnancy-induced hypertension group,at the same period, 30 healthy pregnant women with a full-term pregnancy were selected as the normal pregnancy group and 20 non-pregnant healthy women were as the healthy control group.The levels of PAPP-A,urinary transferrin and D-dimer were observed in pregnancy-induced hypertension group,normal pregnancy group and healthy control group,their levels and disease severity were detected in pregnancy-induced hypertension group and their relationship was explored. Results The levels of PAPP-A,urinary transferrin and D-dimer in pregnancy-induced hypertension group were significantly higher than those of normal pregnancy group and healthy control group (P < 0.01 ),and the levels in normal pregnancy group were also higher compared with those of healthy control group (P <0.01),as the severity of pregnancy-induced hypertension increased,the levels of PAPP-A,urinary transferrin and D-dimer increased (P <0.01).There were positive correlation between PAPP-A and urinary transferrin (r =0.593,P <0.01)or D-dimer (r=0.692,P <0.01),while there were positive correlation between D-dimer and urinary transferrin (r =0.622,P <0.01).Conclusion There are of great significances between the severity of pregnancy-induced hypertension and levels of PAPP-A,urinary transferrin,D-dimmer,and the items can be provided for the early diagnosis and treatment of pregnancy-induced hypertension.%目的:观察妊娠相关蛋白 A(PAPP-A)、尿转铁蛋白、D-二聚体在妊娠期高血压疾病患者检测中的意义及其相关性分析。方法选择在我院就诊的妊娠期高血压疾病患者120例,为妊娠期高血压疾病组,选择同期足月妊娠的健康孕妇30例,为正常妊娠组,选

  14. The Influence of Demographic Variables on University Students' Adjustment in North Jordan

    Science.gov (United States)

    Aderi, Mohd; Jdaitawi, Malek; Ishak, Noor Azniza; Jdaitawi, Farid

    2013-01-01

    The main aim of the present study is to investigate the student university adjustment particularly the determination of the adjustment level of first year university students in Jordan. The three domains are namely overall college adjustment, domain of social adjustment, and academic adjustment. In addition, in this analysis, gender, age, types of…

  15. Adjustment of macroeconomic imbalances

    Directory of Open Access Journals (Sweden)

    Georgeta Barbulescu

    2013-03-01

    Full Text Available The global financial and economic crisis was the factor that triggered the adjustment of macroeconomic imbalances accumulated in Romania. The current account deficit and budget deficit were two major structural imbalances that have created a high vulnerability for the economy and explained the extent of economic contraction in Romania during the economic crisis. This article identifies the main causes that lead to the need for fiscal adjustment both in the EU and in Romania, as well as main effects of adjustments in respect of their experience in recent years. The article deals with this topic, because the current topical debate in the field of fiscal adjustments implemented both in the EU and our country, and their need for economic activity aimed at economic recovery.

  16. Adjustments and Depression

    Medline Plus

    Full Text Available ... thoughts and feelings and is something that takes time. The goal of adjusting is to rebuild one's ... updates about our impact > Get the Reeve newsletter International support > Pages in other languages Made with ♡ in ...

  17. Adjustments and Depression

    Medline Plus

    Full Text Available ... identity and to find a new balance in relationships. The stages of adjustment can include grieving, taking ... treatment options. Related pages What is a complete vs incomplete injury? What emergency procedures occur following an ...

  18. Adjustments and Depression

    Medline Plus

    Full Text Available ... rebuild one's identity and to find a new balance in relationships. The stages of adjustment can include ... a peer mentor Advocate for change Fundraise with Team Reeve Champions Committee Volunteering About Us Our story ...

  19. Family Adjustment to Aphasia

    Science.gov (United States)

    ... Public / Speech, Language and Swallowing / Disorders and Diseases Family Adjustment to Aphasia Richard S. was a senior manager ... It also presents a great challenge to the family. There may be tension among family members and ...

  20. Occupational Adjustment of Immigrants

    OpenAIRE

    Zorlu, Aslan

    2011-01-01

    This paper examines the speed of the occupational adjustment of immigrants using Labour Force Surveys 2004 and 2005 from Statistics Netherlands. The analysis provides new evidence that immigrants start with jobs at the lower levels of skill distribution. Their occupational achievement improves significantly with the duration of residence. The extent of this initial disadvantage and the rate of adjustment vary across immigrant groups according to the transferability of skills associated with t...

  1. KVA: Capital Valuation Adjustment

    OpenAIRE

    Andrew Green; Chris Kenyon

    2014-01-01

    Credit (CVA), Debit (DVA) and Funding Valuation Adjustments (FVA) are now familiar valuation adjustments made to the value of a portfolio of derivatives to account for credit risks and funding costs. However, recent changes in the regulatory regime and the increases in regulatory capital requirements has led many banks to include the cost of capital in derivative pricing. This paper formalises the addition of cost of capital by extending the Burgard-Kjaer (2013) semi-replication approach to C...

  2. Adjustment of Romanian Immigrant Students in a New Educational Context

    Directory of Open Access Journals (Sweden)

    Aniella Mihaela VIERIU

    2014-06-01

    Full Text Available The present study focuses on the adjustment of Romanian immigrant students in emigration schools. The sample was comprised of 102 Romanian immigrant students, 40 male and 62 female, between the ages of 11 and 18, attending different schools in countries such as Spain, Italy and Belgium. Students’ adjustment was investigated by means of a questionnaire consisting of four subscales: linguistic adaptation, cultural adaptation, school adjustment and teacher-student relationship. Results indicate that while immigrant students have a satisfactory level of educational and linguistic adjustment, the social adjustment is less satisfactory. We also obtained correlations between linguistic adaptation and school adjustment, linguistic adaptation and social adaptation, linguistic adaptation and teacher-student relationship, school adjustment and social adaptation, school adjustment and teacher-student relationship, social adaptation and teacher-student relationship. Other correlations were found between the number of years that Romanian immigrant students spent in the host country and linguistic adaptation, school adjustment and teacher-student relationship.

  3. Weighted triangulation adjustment

    Science.gov (United States)

    Anderson, Walter L.

    1969-01-01

    The variation of coordinates method is employed to perform a weighted least squares adjustment of horizontal survey networks. Geodetic coordinates are required for each fixed and adjustable station. A preliminary inverse geodetic position computation is made for each observed line. Weights associated with each observed equation for direction, azimuth, and distance are applied in the formation of the normal equations in-the least squares adjustment. The number of normal equations that may be solved is twice the number of new stations and less than 150. When the normal equations are solved, shifts are produced at adjustable stations. Previously computed correction factors are applied to the shifts and a most probable geodetic position is found for each adjustable station. Pinal azimuths and distances are computed. These may be written onto magnetic tape for subsequent computation of state plane or grid coordinates. Input consists of punch cards containing project identification, program options, and position and observation information. Results listed include preliminary and final positions, residuals, observation equations, solution of the normal equations showing magnitudes of shifts, and a plot of each adjusted and fixed station. During processing, data sets containing irrecoverable errors are rejected and the type of error is listed. The computer resumes processing of additional data sets.. Other conditions cause warning-errors to be issued, and processing continues with the current data set.

  4. D-二聚体对老年重症社区获得性肺炎30天死亡率的预测价值%Predictivevalue of D-dimer in 30-day mortality of elderly patients with severe community-acquired pneumonia

    Institute of Scientific and Technical Information of China (English)

    龙威; 黄高忠; 李利娟; 苏文涛; 赵立东

    2014-01-01

    目的:探讨D-二聚体水平对住院老年重症社区获得性肺炎(CAP)患者30d死亡率的预测价值。方法152例符合诊断标准的老年重症CAP患者纳入研究,入院后即进行D-二聚体、C-反应蛋白(CRP)检测及肺炎严重度指数(PSI)评分,记录患者30d死亡率。采用受试者工作特征曲线(ROC)分析D-二聚体对30d死亡率的预测价值,计算曲线下面积(AUC)。结果 PSI评分Ⅳ级患者的D-二聚体水平为(961.55±186.49)µg/L,Ⅴ级为(1122.53±197.98)µg/L,两者差异有明显统计学意义(t=5.159,P<0.001);死亡患者的D-二聚体水平(1112.59±215.25)µg/L明显高于存活患者的D-二聚体水平(920.46±126.89)µg/L(t=6.239,P<0.001)。Pearson相关性分析显示,D-二聚体和PSI有明显相关性(r=0.47,P<0.0001);ROC分析表明D-二聚体的AUC为:0.79(95%CI:0.72~0.85),和PSI的AUC相比差异无统计学意义(0.85,95%CI:0.78~0.91,P=0.095)。结论 D-二聚体水平对住院老年重症CAP患者30d死亡率有较好预测价值。%ObjectiveToinvestigate the value ofplasmaD-dimerlevelin predicting 30-day mortalityfortheelderly patients with severe community-acquired pneumonia (CAP).Methods A total of 152 elderly inpatients(over 60 years old)withidentifiedsevere CAPadmitted in our department from August 2009 to August 2011were enrolled in this study.Immediately after admission,theirblood samples were obtained forplasma levels ofD-dimer and C-reactive protein(CRP),and pneumonia severity index (PSI) was calculated. Clinical and laboratory variables and 30-day mortality were recorded.Receiver operating characteristic(ROC) curve was used to assess the value of D-dimerfor predicting 30-day mortality, and thearea under curve(AUC)was calculated.ResultsTheD-dimer levelswere (961.55±186.49)µg/Lin the patients with PSIscore inclassⅣ, and(1122.53±197.98)µg/L for those with score inclass

  5. 高压氧联合神经节苷脂对脑出血患者凝血酶、血清髓鞘碱性蛋白、D-二聚体的影响%Effect of hyperbaric oxygen combined with ganglion glycosides on thrombin, serum myelin basic protein and D-dimer in patients with intracerebral hemorrhage

    Institute of Scientific and Technical Information of China (English)

    陈伟; 王茂德; 王宁; 鲍刚; 王拓

    2016-01-01

    Objective To observe the effect of hyperbaric oxygen combined with ganglion glycosides on thrombin, se-rum myelin basic protein and D-dimer in patients with intracerebral hemorrhage.Methods Selected from June 2014 to June 2015, 100 cases of cerebral hemorrhage patients in Xi'an Jiaotong University First Affiliated Hospital neurosurgery department as the research object, according to the order of admission, they were randomly divided into control group and observation group, each group of 50 cases, on the basis of conventional therapy patients in control group were treated with ganglioside treatment, the observation group given hyperbaric oxygen combined with ganglioside treatment.Before and after treatment, thrombin, serum myelin basic protein, D-dimer, hematoma volume, neurological function defect score ( NIHSS) , daily life a-bility score ( ADL) were observed, and the clinical effect was evaluated.Results Before treatment, 2 groups of thrombin, serum myelin basic protein ( MBP) , D-dimer, volume of hematoma, NIHSS and ADL score differences had no statistical sig-nificance ( P >0.05), after treatment, two groups of thrombin, serum myelin basic protein (MBP), D-dimer, hematoma volume and NIHSS score compared with those before treatment were significantly decreased ( P <0.05), ADL score before treatment were significantly higher ( P <0.05) , and the observation group was more obvious than that of the control group, the above indicators improved ( P <0.05).The control group cured rate, significant progress rate, improvement rate were 24.00%, 36.00%, 24.00%, the observation group were 30.00%and 40.00%, 24.00%observed group, the total efficien-cy is remarkably higher than that of the control group (94.00%vs.84.00%,χ2 =3.55, P <0.05).Conclusion Hyperbaric oxygen combined with ganglion glycosides can reduce the level of thrombin, serum myelin basic protein and D-dimer levels in patients with cerebral hemorrhage,and improve the therapeutic effect.%目的:观察高压

  6. Predicting deep venous thrombosis using Wells scoring system combined with D-dimer and fibrin degradation product%复合骨折后下肢深静脉血栓形成Wells评分与D-二聚体及纤维蛋白降解产物的预测

    Institute of Scientific and Technical Information of China (English)

    沈明荃; 谢增如

    2014-01-01

    背景:文献报道各种对深静脉血栓形成的诊断方法,但是结合危险度预测评分系统及多种实验室指标对深静脉血栓形成的预测诊断率的提高尚不明确。  目的:使用Wel s评分系统并结合D-二聚体及纤维蛋白降解产物提高诊断创伤后下肢深静脉血栓敏感性。方法:下肢骨折及脊柱骨折患者82例,排除患病前合并深静脉血栓形成高危因素的患者及曾患有深静脉血栓形成的患者。入院后检测患者D-二聚体、纤维蛋白酶原降解产物、纤维蛋白酶原、凝血酶原时间、部分活化凝血酶原时间、血小板计数、C-反应蛋白及血沉相关指标,并做彩色多普勒下肢超声检测。根据下肢深静脉栓塞评分表(Wel s评分表)评分分为低危、中危及高危患者。  结果与结论:彩色多普勒下肢超声检测深静脉血栓形成组30例;非深静脉血栓形成组52例,两组患者 D-二聚体及纤维蛋白降解产物的峰值差异有显著性意义(P OBJECTIVE:To improve the diagnosis sensitivity of traumatic deep venous thrombosis of lower extremity using Wel s scoring system combined D-dimer and fibrin degradation product. METHODA total of 82 patients with low limb fractures and spine fracture were included in this study, those patients with high risk factors of deep venous thrombosis or with the history of deep venous thrombosis were excluded. After admission, the fol owing indicators of deep venous thrombosis were determined, including D-dimer, fibrin degradation product, fibrinogenase, prothrombin time, activated partial thrombokinase time, blood platelets count, C-reaction protein, and erythrocyte sedimentation rate. In addition, Doppler ultrasound detection of double lower limbs deep vein was performed, and the results were recorded. According to scoring system of deep venous thrombosis of lower extremity (Wel s scoring system), the patients were assigned into low-risk, middle

  7. Sustainable urban regime adjustments

    DEFF Research Database (Denmark)

    Quitzau, Maj-Britt; Jensen, Jens Stissing; Elle, Morten;

    2013-01-01

    The endogenous agency that urban governments increasingly portray by making conscious and planned efforts to adjust the regimes they operate within is currently not well captured in transition studies. There is a need to acknowledge the ambiguity of regime enactment at the urban scale. This directs......, inspired by Actor-Network Theory to demonstrate that regime incumbent actors can induce gradual regime adjustments at the urban scale. This is done through a case study of an urban development project, where the Municipality of Egedal in Denmark has successfully promoted energy efficient buildings through...

  8. The validity of Wells'Criteria and Geneva Scoring System (revised) combined with D-dimer in predicting pulmonary embolism%Wells 量表和修正的 Geneva 评分联合 D-二聚体对肺栓塞的预测价值

    Institute of Scientific and Technical Information of China (English)

    凌燕君; 邹晓

    2015-01-01

    目的:评价Wells量表和修正的Geneva评分系统联合D-二聚体诊断肺栓塞的意义。方法应用受试者工作特征曲线,通过Wells量表和修正的Geneva评分系统联合D-二聚体检验方法,得出修正的Geneva和Wells评分,联合D-二聚体阳性来比较两种方法的差别。结果通过Wells评分的ROC曲线得出以≥4.25作为预测值,其灵敏度30.2%,特异度92.6%;通过Geneva评分的ROC曲线得细化以≥6.5作为预测值,其灵敏度64.7%,特异度85.2%。在Wells评分中以最佳分界值4.25分为界,Geneva评分中以最佳分界值6.5分为界,联合D-二聚体检测准确率有明显差别。结论根据Geneva评分≥6.5分或Wells评分≥4.25分者联合D-二聚体阳性时,高度怀疑肺栓塞。%Objective To evaluate the validity of Wells’ Criteria and Geneva Scoring System combined with D-dimer as two different methods for predicting pulmonary embolism.Method The Wells score and the Geneva score were first obtained by the Wells’ Criteria and the Geneva Scoring System ( revised) combined with D – dimer respectively.The validity of the two methods was then evaluated and compared for their difference in accuracy sensitivity, and specificity.Findings The Wells score evaluated by the ROC curve was≥4.25 as the predictive value.Its sensitivity was 30.2%and its specificity of 92.6%.The Geneva score evaluated by the ROC curve was refined to≥6.5 as the predictive value.Its sensitivity was 64. 7%and its specificity of 85.2%.Of the Wells scores the best cutoff value was 4.25 while of the Geneva optimal the optimal cutoff score was 6.5.Combined with D-dimer, significant difference could be found between the two methods. Conclusion The sensitivity and specificity of the revised Geneva score were better than those of the Wells rule.When the revised Geneva scores arrive at a value≥6.5 or the Wells scores arrive a value≥4.25, and the D-dimer is positive

  9. The significance of detection of D-dimer, fibrinogen and antithrombin-Ⅲin the patients with typy-2 diabet-ic nephropathy%D-二聚体、纤维蛋白原及抗凝血酶Ⅲ联合检测对早期2型糖尿病肾病的诊断价值

    Institute of Scientific and Technical Information of China (English)

    杨玲

    2015-01-01

    目的:探究D-二聚体、纤维蛋白原( FIB)及抗凝血酶Ⅲ( AT-Ⅲ)联合检测2型糖尿病早期肾损伤的临床诊断价值。方法选取某院2型糖尿病患者206例,根据24 h尿白蛋白排泄率( UAE)分为无蛋白尿组116例( UAE<30 mg/24 h)与微量白蛋白尿组90例(30 mg/24 h≤UAE<300 mg/24 h),并选取同期健康体检者103例作为健康对照组,比较血浆D-二聚体、FIB、AT-Ⅲ3项指标的变化。结果微量白蛋白尿组D-二聚体、FIB含量明显高于无蛋白尿组和健康对照组,差异均有统计学意义(P<0畅05),而三组AT-Ⅲ的活性比较差异无统计学意义(P>0畅05)。3项指标联合检测的微量蛋白尿组患者为93畅3%,比单项检测的阳性率高,差异有统计学意义(P<0畅05)。 D-二聚体、FIB、AT-Ⅲ与尿白蛋白排泄率呈正相关,相关系数(r)依次为0畅812、0畅672、0畅621(P<0畅05)。结论 D-二聚体、FIB检测对于2型糖尿病肾病的早期判断以及疾病的早期预防和病情监测有重要意义。%Objective To explore the D-dimer, fibrinogen (FIB), antithrombin Ⅲ (AT-Ⅲ) joint detection of early renal damage in type 2 diabetes to assess the diagnostic value of clinical application.Methods According to the 24 h urine albumin excre-tion rate ( UAE) , 206 patients selected from type 2 diabetes patients were divided into 116 cases without albuminuria group ( UAE0.05).Three indicators of joint detection of trace albuminuria group of patients was 93.3%, positive rate than single detection are high, the difference was statistically significant (P<0.05).D-dimer, FIB, the AT-Ⅲand UAE are positively related to the level of the correlation coefficient r of 0.812, 0.672, and 0.621 (P<0.05).Conclusion The detection of D-dimer, FIB in type 2 diabetic nephropathy early judgement and early prevention of disease and illness monitoring is im-portant.

  10. 重症肺炎患者FDP、D-二聚体和炎症指标的变化及临床意义%Change and the clinical significance of fibrinogen degradation products,D-dimer and inflammatory indicators in the patients with severe pneumonia

    Institute of Scientific and Technical Information of China (English)

    徐巧巧; 邢丽华

    2015-01-01

    Objective To observe the change of fibrinolytic system function,D-dimer and inflammatory index in the patients with severe pneumonia,and to investigate the clinical significance.Methods Forty patients with severe pnemonia from June 2013 to June 2014 in the RICU in the first affiliated hospital of Zhengzhou university and forty cases of health check-up in the same period in the physical examination center were selected.The fibrinogen degradation (FDP),D-dimer (D-D),procalcitonin (PCT),C-reactive protien(CRP),erythrocyte sedimentation rate (ESR) in the serum were tested.Results Campared with the control group,the FDP and D-D significanty increased and the value of PCT,CRP,ESR elevated in the group with severe pneumonia(P <0.05).Conclusions The FDP and the D-D can reflect the function of blood coagulation system.The mechanism of coagulation and fibrinolytic function becomes disorder for the patients with severe pneumonia,which is related to the inflamamation.So observation for the changes of the above indexes might be helpful for the conditon assessment and the treatment.%目的 探讨重症肺炎患者纤溶系统功能和炎症指标的变化及临床意义.方法 选取2013年6月至2014年6月期间入住郑州大学第一附属医院RICU的40例重症肺炎患者与本院体检中心同期40例健康体检者作为研究对象,分别测定其血清中的纤维蛋白原降解产物(FDP)、D-二聚体(D-D)、降钙素原(PCT)、C-反应蛋白(CRP)、血沉(ESR).结果 重症肺炎组FDP及D-D明显升高,PCT、CRP、ESR水平升高,与正常对照组比较差异有统计学意义(P<0.05).结论 重症肺炎患者存在凝血纤溶系统功能的紊乱与炎症反应有关,FDP和D-D反应凝血纤溶系统的功能,注意FDP、D-D及炎症指标的变化在重症肺炎病情评估及指导治疗中具有一定价值.

  11. 妊娠高血压患者与D-二聚体、维生素B12、血清同型半胱氨酸的关系%The relationship between pregnancy-induced hypertension and D-dimer, vitamin B12 and serum homocysteine

    Institute of Scientific and Technical Information of China (English)

    俞小飞; 徐燕; 张梦

    2015-01-01

    目的:探讨不同孕期孕妇D-二聚体(D-D)、维生素B12、血清同型半胱氨酸(HCY)与妊娠高血压疾病(PIH)之间的关系。方法:选取在我院进行产检的孕妇287例为研究对象,其中PIH孕妇86例,正常妊娠孕妇201例,根据孕期对不同孕妇血清D-D、维生素B12、HCY水平进行检测。结果:PIH组与正常妊娠组比较,孕中期及孕晚期血清HCY水平与D-D水平明显升高(P<0.05),且在孕中期及孕晚期,PIH组及正常妊娠组孕妇血清HCY水平与D-D水平呈正相关,而与维生素B12均无相关性。结论:在孕中晚期进行HCY水平及D-D水平检测可作为预测PIH的一个重要的危险因素。%Objective:To evaluate the Relationship between the serum levels of homocysteine, D-dimer, vitamin B12 and pregnancy-induced hypertension in different pregnancies. Methods:287 pregnant women who registered for prenatal examination of pregnant in the hospital were selected as research subjects. And there were 86 cases of PIH and 201 cases of normal pregnancy among them. The serum levels of homocysteine, D-dimer, vitamin B12 were detected according to different pregnancy.Results:Compared with normal pregnancy group, the serum HCY and D-D level of PIH group significantly increased in medium and late pregnancy periods (P0.05). Conclusions:n middle and late pregnancy periods, to detect the levels of HCY and D-D be an improtant risk factor of PIH.

  12. 急性冠脉综合征中超敏C反应蛋白联合D-二聚体检测的研究进展%THE DEVELOPMENT OF COMBINED TESTING OF HYPER-SENSITIVE C REACTIVE PROTEIN AND D-DIMER IN ACUTE CORONARY SYMDROME

    Institute of Scientific and Technical Information of China (English)

    杜丽萍; 扈瑞平; 王学磊; 曾显坤

    2015-01-01

    ACS的临床表现可为,胸闷、胸痛伴气短、出汗,心衰,心律失常以及猝死。并伴有冠脉血管痉挛,管腔明显狭窄,甚至完全被堵塞,从而出现心肌缺血缺氧,严重时心肌坏死[1]。近年来研究发现:其进展过程中伴随的生化标记物超敏C反应蛋白、D-二聚体的改变可帮助临床医师及早识别病人的临床症状并为心电图改变不典型病人提供积极个体化的治疗方案,同时对评估其病情及预后、起到极大的作用。现将对急性冠脉综合征中( ACS)超敏C反应蛋白联合D-二聚体检测的研究进展进行综述。%Acute coronary symdrome( ACS) is caused by cononary atherosclerosis rupture, platelet adhesion, platelet aggregation, platelet release, through which the coagulation system is activated leading to the blood clot. ACS is usually accompanied by vasospasm,stenosis of arte-rioles,even worse,myocardial ischemia from completely blocking and myocardial necrosis. The research tells us that through biochemical marker-hyper sensitive C reactive protein and D-dimer ( increase ) , phisician can recognize some symdromes in early time,help ACS patients with atypical ECG changes and give them individual treatment;in addition,the two marker also play an important role in evaluating severity and prognosis. This review will present development in application of hyper-sensitive C reative protein and D-dimer in ACS.

  13. The Kenyan Political Conflict and Children's Adjustment

    Science.gov (United States)

    Kithakye, Mumbe; Morris, Amanda Sheffield; Terranova, Andrew M.; Myers, Sonya S.

    2010-01-01

    This study examined pre- and postconflict data from 84 children, ages 3-7 years, living in Kibera, Kenya, during the December 2007 political conflict. Results indicate that children's disaster experiences (home destruction, death of a parent, parent and child harm) are associated with adjustment difficulties and that emotion regulation is an…

  14. Auto Adjusting Astronomical Telescope

    Directory of Open Access Journals (Sweden)

    Rohit R. Ghalsasi

    2014-04-01

    Full Text Available Astronomical telescope is powerful and basic tool for star or celestial observation. Here we proposed integrated system using Raspberry Pi for auto adjusting astronomical telescope. This integrated circuit helps to control stellar monitoring, stellar targeting, and tracking functions of telescope. Astro compass gives the direction of the celestial objects.

  15. Neighborhood Assets and Adolescent Adjustment

    Directory of Open Access Journals (Sweden)

    Alfredo Oliva Delgado

    2011-12-01

    Full Text Available This paper presents the results of a study analyzing the relationship between some dimensions or developmental assets in the neighborhood, as measured by the Scale for the Assessment of Developmental Assets in the Neighborhood, and adjustment and life satisfaction of adolescent boys and girls. The sample consisted of 2400 adolescents (1068 boys and 1332 girls between ages 12 and 17 who were secondary students in public and private schools in Western Andalusia. The results showed significant relationships between most dimensions of the scale (youth empowerment, attachment to neighbourhood safety and social control and internalizing and externalizing problems, substance use and life satisfaction of participants. Moreover, the data provide evidence about the external validity of the scale used in the study. From the results some suggestions for intervention in the community environment are extracted.

  16. Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis Avaliação dos níveis séricos de D-dímeros entre doentes com urticária crônica, psoríase e urticária vasculite

    Directory of Open Access Journals (Sweden)

    Paulo Ricardo Criado

    2013-06-01

    Full Text Available BACKGROUND: It has been demonstrated that neutrophils, eosinophils and monocytes, under appropriated stimulus, may express tissue factor and therefore, activate the extrinsic pathway of coagulation. We performed a transversal and case-control study of patients with chronic urticaria and patients with psoriasis, in our outpatient clinic to evaluate the production of D-dimer. OBJECTIVE: To evaluate D-dimer serum levels in patients with chronic urticaria and its possible correlation with disease activity. PATIENTS AND METHODS: The study was conducted from October 2010 until March 2011. We selected 37 consecutive patients from our Allergy Unit and Psoriasis Unit, and divided them into three groups for statistical analysis: (i 12 patients with active chronic urticaria (CU; (ii 10 patients with chronic urticaria under remission and (iii 15 patients with psoriasis (a disease with skin inflammatory infiltrate constituted by neutrophils, lymphocytes and monocytes. Another five patients with urticarial vasculitis were allocated in our study, but not included in statistical analysis. The serum levels of D-dimer were measured by Enzyme Linked Fluorescent Assay (ELFA, and the result units were given in ng/ml FEU. RESULTS: Patients with active chronic urticaria had the highest serum levels of D-dimer (p FUNDAMENTOS: Tem sido demonstrado que os neutrófilos, eosinófilos e monócitos, sob estímulo apropriado, podem expressar fator tecidual e, portanto, ativar a via extrínseca da coagulação. Realizamos um estudo transversal e caso-controle de pacientes com urticária crônica e pacientes com psoríase em nosso ambulatório para avaliar a produção de dímero-D. OBJETIVO: Avaliar níveis de dímero-D em pacientes com urticária crônica e sua possível correlação com a atividade da doença. PACIENTES E MÉTODOS: O estudo foi conduzido de outubro de 2010 até março de 2011. Nós selecionamos 37 pacientes consecutivos da Unidade de Alergia e Unidade de

  17. Credit Valuation Adjustment

    OpenAIRE

    Hoffman, Frederick

    2011-01-01

    Credit risk has become a topical issue since the 2007 Credit Crisis, particularly for its impact on the valuation of OTC derivatives. This becomes critical when the credit risk of entities involved in a contract either as underlying or counterparty become highly correlated as is the case during macroeconomic shocks. It impacts the valuation of such contracts through an additional term, the credit valuation adjustment (CVA). This can become large with such correlation. This thesis outlines the...

  18. Fiscal adjustment in Brazil

    Directory of Open Access Journals (Sweden)

    Fabiana Rocha

    2003-03-01

    Full Text Available Two questions are addressed in this paper. The first one is the determination of periods of fiscal consolidation and fiscal stimulus. The second one is the importance of the composition of fiscal adjustments for their success, defined as a declining debt to GDP ratio. We, characterize 1994 and 1999 as points of fiscal consolidation. The 1994 consolidation can not be considered successful since after that period the debt to GDP ratio has grown continuously. The adjustment can be characterized as a type 2 adjustment (Alesina and Perotti (1997 in the sense that cuts were made mainly in public investment, while government wages and transfers remained almost unchanged. This type of adjustment usually has a low likelihood of being a success.Duas questões são tratadas neste artigo. A primeira é a determinação dos períodos de consolidação fiscal e estímulo fiscal. A segunda questão é a importância da composição dos ajustamentos fiscais para o seu sucesso, definido como um declínio na razo dívida/PIB. Nós, caracterizamos 1994 e 1999 como pontos de consolidação fiscal. A consolidação de 1994 não pode ser considerada um sucesso pois nos anos seguintes a razão dívida/PIB cresceu continuamente. O ajustamento pode ser considerado como um ajustamento do tipo 2 (Alesina and Perotti, 1997 no sentido de que foram feitos cortes principalmente no investimento público, enquanto os salários e transferências permaneceram praticamente inalterados. Este tipo de ajustamento geralmente tem uma baixa probabilidade de sucesso.

  19. The Kenyan political conflict and children's adjustment.

    Science.gov (United States)

    Kithakye, Mumbe; Morris, Amanda Sheffield; Terranova, Andrew M; Myers, Sonya S

    2010-01-01

    This study examined pre- and postconflict data from 84 children, ages 3-7 years, living in Kibera, Kenya, during the December 2007 political conflict. Results indicate that children's disaster experiences (home destruction, death of a parent, parent and child harm) are associated with adjustment difficulties and that emotion regulation is an important protective factor postdisaster. Specifically, severity of the disaster experience was associated with increased aggression and decreased prosocial behavior. Emotion regulation was associated with less aggression and more prosocial behavior postconflict. Findings are discussed in the context of a developmental, systems-oriented perspective of the impact of disasters on child adjustment.

  20. Adjustment Criterion and Algorithm in Adjustment Model with Uncertain

    Directory of Open Access Journals (Sweden)

    SONG Yingchun

    2015-02-01

    Full Text Available Uncertainty often exists in the process of obtaining measurement data, which affects the reliability of parameter estimation. This paper establishes a new adjustment model in which uncertainty is incorporated into the function model as a parameter. A new adjustment criterion and its iterative algorithm are given based on uncertainty propagation law in the residual error, in which the maximum possible uncertainty is minimized. This paper also analyzes, with examples, the different adjustment criteria and features of optimal solutions about the least-squares adjustment, the uncertainty adjustment and total least-squares adjustment. Existing error theory is extended with new observational data processing method about uncertainty.

  1. Adjustment of Romanian Immigrant Students in a New Educational Context

    OpenAIRE

    Aniella Mihaela VIERIU

    2014-01-01

    The present study focuses on the adjustment of Romanian immigrant students in emigration schools. The sample was comprised of 102 Romanian immigrant students, 40 male and 62 female, between the ages of 11 and 18, attending different schools in countries such as Spain, Italy and Belgium. Students’ adjustment was investigated by means of a questionnaire consisting of four subscales: linguistic adaptation, cultural adaptation, school adjustment and teacher-student relationship. Results indicate ...

  2. Children's Adjustment in Joint and Sole Physical Custody Families.

    Science.gov (United States)

    Kline, Marsha; And Others

    1989-01-01

    Examined patterns of custody and their relationship to the behavioral-emotional and social adjustment of 93 children of 3-14 years of age. Found no evidence that joint physical custody arrangements differ from sole physical custody arrangements with regard to postdivorce child adjustment. (RH)

  3. Newcomer Adjustment among Recent College Graduates: An Integrative Literature Review

    Science.gov (United States)

    Klemme Larson, Rachel E.; Bell, Alexandra A.

    2013-01-01

    Newcomer adjustment, the process an individual goes through within the first year at a new organization, can be a challenging transition for traditionally aged recent college graduates. Unsuccessful adjustment can have profound negative consequences for young adults, organizations, and undergraduate institutions. Gaps exist in the human resource…

  4. Jordan Adjusted Human Development

    OpenAIRE

    Ababsa, Myriam

    2014-01-01

    Jordan Human Development Index (HDI) and Adjusted Human Development Index (IHDI) In 1990, the United Nations Development Programme designed a Human Development Index composed of life expectancy at birth, level of education and gross domestic product (GDP) per capita. In 2011, the UNDP ranked Jordan 95th out of 187 countries with a human development index of 0.698, up from 0.591 in 1990, making it the leading medium-range country for human development (fig. VIII.1). In 2010, the inequality adj...

  5. Ajustamento psicológico e perspectiva de velhice pessoal em adultos com deficiência física Ajuste psicológico e la perspectiva percibida del envejecimiento personal en adulto y adultos moyores con discapacidad física Psychological adjustment and personal aging perspective in adults and older adults with physical disability

    Directory of Open Access Journals (Sweden)

    Marineia Crosara de Resende

    2009-12-01

    exige capacidad adaptante, y resistencia para hacer frente a acontecimientos de vida y a los desafíos personales, sociales y ambientales producidos por la discapacidad.We carried out an investigation to analyze the relationships between perceived psychological adjustment and perspective of personal aging in adult and aged people with physical disability. Materials and Method: 90 participants, both genders, aged 25 to 84 , answered questionnaires asking for information on socio demographic characteristics and disability; the Sheppard Inventory of attitudes toward own aging; and a scale assessing perceived psychological adjustment. Results: The indexes of personal adjustment were moderate and high. The women had the lowest scores. There were observed positive correlations between positive psychological adjustment and positive attitudes toward own aging. Those that had congenital disability and reported higher psychological adjustment showed more positive perspectives of personal aging. Conclusion: Aging with physical disability is a complex process that demands adaptive competence, and resilience to cope with life events and the personal, social and environmental challenges produced by disability.

  6. Fatores de ajustamento da produção de leite e de gordura na raça Holandesa para idade e núcleo de controle leiteiro Age of calving and region adjustment factors for milk and fat yields for graded and purebred Holstein in Minas Gerais State, Brazil

    Directory of Open Access Journals (Sweden)

    M.C. Durães

    2000-04-01

    Full Text Available Foram estimados fatores de ajustamento para produção de leite e de gordura em rebanhos da raça Holandesa do Estado de Minas Gerais, segundo a idade da vaca ao parto, a composição racial e o núcleo de controle leiteiro onde ocorreu o parto. Utilizou-se a metodologia dos modelos mistos, usando-se a máxima verossimilhança restrita em um modelo animal com os efeitos fixos de rebanho-ano, época do parto e classes idade-composição racial-núcleo de controle leiteiro, e os efeitos aleatórios de animal e resíduo. Utilizaram-se 46.971 lactações de 26.822 vacas, sendo 17.354 vacas puras por cruzamento (PC e 9.468 puras de origem (PO. Nos cinco núcleos regionais, denominados 1545, 2585, 5565, 35 e 75, formaram-se 21 classes de idade, sendo a menor constituída de vacas que pariram com menos de 24 meses e a maior pelas vacas com mais de 99 meses de idade. Para as vacas PO, os fatores para ajustamento da produção de leite e de gordura tenderam a ser menores do que os correspondentes valores estimados para as vacas PC; todavia, a variabilidade foi maior nas vacas PO em relação às PC nos núcleos 75, 2585 e 5565. Os fatores para vacas jovens foram maiores do que para vacas de maior idade. Os fatores de ajustamento para produção de gordura foram maiores que os correspondentes para produção de leite. É recomendável utilizar fatores específicos para o ajustamento da produção de leite e de gordura em cada núcleo e grupo racial.Adjustment factors were estimated for milk and fat yields for Holstein herds according to age of cow at calving, genetic group (purebred or graded cows and region of recorded milk yield (nucleus in Minas Gerais State. Statistical analyses used mixed model methodologies by restricted maximum likelihood using animal model. Herd-year, season of calving, age of cow classes, genetic group, and region of recorded milk records were used as fixed effects, and cows and residuals as random effects. Analyses used 46

  7. Adolescent Mothers' Adjustment to Parenting.

    Science.gov (United States)

    Samuels, Valerie Jarvis; And Others

    1994-01-01

    Examined adolescent mothers' adjustment to parenting, self-esteem, social support, and perceptions of baby. Subjects (n=52) responded to questionnaires at two time periods approximately six months apart. Mothers with higher self-esteem at Time 1 had better adjustment at Time 2. Adjustment was predicted by Time 2 variables; contact with baby's…

  8. Technical Document for Price Adjustment

    OpenAIRE

    Zheng Tian; Mulugeta Kahsai; Randall Jackson

    2014-01-01

    This document presents the basis for the price adjustment mechanisms in a time series IO model. The essentials of the price adjustment and price change propagation algorithms are presented, along with a matrix permutation algorithm that facilitates the implementation of the price adjustment mechanism. The Matlab function is provided.

  9. 脑梗死患者 hs-CRP FIB D-二聚体及血脂相关指标检测结果的分析%Analysis of plasma hs-CRP,FIB,D-dimer and lipids related indicators in patients with cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    郑红云; 李艳; 李松

    2014-01-01

    目的:探讨血脂相关指标、超敏C反应蛋白(hs-CRP)、纤维蛋白原(FIB)和D-二聚体水平与脑梗死发病的相关性。方法选取脑梗死患者259例(脑梗死组),同期健康体检者210例作为对照组。采用酶比色法测定血脂相关指标[总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白(Apo)A1、ApoB、ApoE]水平;采用荧光免疫干式定量法测定hs-CRP ;用凝固法检测FIB ;采用免疫比浊法测定D-二聚体水平。结果与对照组相比,脑梗死患病组TG、LDL-C、ApoA1、ApoE、hs-CRP、D-二聚体及FIB水平均显著升高(P<0.01),而 HDL-C水平则显著降低(P<0.01),TC与A poB水平差异无统计学意义( P>0.05)。结论炎症、血脂、凝血与纤溶系统可相互影响,并与脑梗死的发生和发展关系密切,联合检测有助于辅助诊断脑梗死。%Objective To study the lipids related indicators ,high-sensitivity C-reactive protein(hs-CRP) ,FIB and D-dimer levels in cerebral infarction patients .Methods 259 cerebral infraction patients(cerebral infraction group) and 210 healthy individuals(con-trol group) were enrolled in the study .Plasma lipids related indicators such as TC ,TG ,HDL-C ,LDL-C ,ApoA1 ,ApoB ,ApoE levels were measured by enzymatic colorimetric assay .Quantitative fluorescence immunoassay was used to determine serum level of hs-CRP .FIB levels were determined by using coagulation method ,and D-dimer levels by using immune turbidimetric method .Results Compared with the control group ,the TG ,LDL-C ,ApoA1 ,ApoE and hs-CRP levels were significantly higher in the cerebral infarc-tion group(P0 .05) .Conclusion Lipids ,inflammation ,coagulation and fibrinolysis are closely relat-ed in the development of cerebral infarction ,and combined detection helps diagnose cerebral infarction .

  10. Metric adjusted skew information

    DEFF Research Database (Denmark)

    Hansen, Frank

    2008-01-01

    We extend the concept of Wigner-Yanase-Dyson skew information to something we call "metric adjusted skew information" (of a state with respect to a conserved observable). This "skew information" is intended to be a non-negative quantity bounded by the variance (of an observable in a state......) that vanishes for observables commuting with the state. We show that the skew information is a convex function on the manifold of states. It also satisfies other requirements, proposed by Wigner and Yanase, for an effective measure-of-information content of a state relative to a conserved observable. We...... establish a connection between the geometrical formulation of quantum statistics as proposed by Chentsov and Morozova and measures of quantum information as introduced by Wigner and Yanase and extended in this article. We show that the set of normalized Morozova-Chentsov functions describing the possible...

  11. Adjusting to the Emergent

    DEFF Research Database (Denmark)

    Revsbæk, Line

    In her doctoral thesis Line Revsbaek explores newcomer innovation related to organizational entry processes in a changing organization. She introduces process philosophy and complexity theory to research on organizational socialization and newcomer innovation. The study challenges assumptions...... in standardized induction programs where newcomers are cast in roles as insecure novices needing to be “taught the ropes” of the organizational culture. Linked with this, it is suggested that the prevailing dichotomy of ‘newcomer assimilation’ versus ‘organizational accommodation’ is replaced with a notion...... of ‘adjusting to the emergent’. Newcomer innovation is portrayed as carrying a variety of possible significations, such as unintentional innovation effects of newcomer’s proactive self-socializing behavior; an inspirational basis for designing innovation-generating employee induction; ‘resonant instances...

  12. Expression of ICAM-1, P-selectin, D-dimer in placental tissue and matemal plasm of preeclampsia patients%ICAM-1、P-selectin、D-dimer在子痫前期胎盘和血浆表达研究

    Institute of Scientific and Technical Information of China (English)

    岳永飞; 许多

    2014-01-01

    目的 探讨细胞间黏附分子(ICAM-1)、p-选择素(P-selectin)、D二聚体(D-dimer)在子痫前期发生发展中的作用.方法 随机选取子痫前期患者39例为研究组,37例正常妊娠孕妇为对照组,采用免疫组织化学技术检测两组胎盘组织中ICAM-l、P-selectin的表达情况;采用酶联免疫吸附法(ELISA)检测两组血浆ICAM-1、P-selectin和D-dimer的表达水平.结果 子痫前期组胎盘ICAM-1、P-selectin的表达明显高于对照组(P<0.05);两组血浆均有ICAM-1、P-selectin和D-dimer的表达,子痫前期组的血浆ICAM-1、P-selectin和D-dimer表达明显高于对照组(P<0.05).结论 子痫前期患者ICAM-1、P-selectin和D-dimer表达升高可能与子痫前期的发生发展有关,监测这些指标对病情判断及指导治疗具有重要意义.

  13. Adjusting to Changes

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    China’s population has increased to 1.37 billion,including 1.3397 billion on the mainland,said the National Bureau of Statistics when releasing results of the country’s sixth national population census at the end of April.The country also has the world’s largest elderly population of 178 million people aged 60 and older,

  14. Predictive value of serum cholinesterase for the prognosis of aged patients with systemic inflammatory response syndrome

    Institute of Scientific and Technical Information of China (English)

    JIN Qi-hui; HE Xiao-jun; LI Tian-lang; CHEN Huai-hong

    2011-01-01

    Background Some studies found that cholinesterase (ChE) can be an independent risk factor for patients with multiple organ dysfunction syndrome.To assess aged patients with systemic inflammatory response syndrome (SIRS) early and predict their prognosis,the predictive value of ChE for the prognosis of aged patients with SIRS was analyzed.Methods From September 2009 to September 2010,all aged patients with SIRS in the ICU of the Second Affiliated Hospital of Zhejiang University School of Medicine were retrospectively analyzed if they met inclusion criteria:patients aged >65 years and met American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference criteria for SIRS.Serum ChE,albumin,D-dimer,lactic acid and C-reactive protein (CRP) were measured,and the Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ and Glasgow Coma Scale (GCS) scores were evaluated within the first 24 hours in the ICU.Fisher's exact test was used for comparison of the primary disease between the deceased group and surviving group.For comparison of study variables between the two groups,the Student's t test or Mann-Whitney U test was used.Multivariate significance was tested with binary Logistic regression analysis.Results The clinical data of 124 aged patients with SIRS were collected and analyzed.Sixty-six patients (46 male,20female,mean age (78.70±8.08) years) who died were included in the deceased group and 58 patients (34 male,24female,mean age (76.02±6.57) years) who survived were included in the surviving group.There were no significant differences in age,gender,APACHE Ⅱ score and GCS score between the deceased group and surviving group (all P>0.05),but there were significant differences in lactic acid (P=0.011),D-dimer (P=0.011),albumin (P=0.007),CRP (P=0.008),and ChE (P <0.0001).The correlation analysis showed that the APACHE Ⅱ score and CRP were not correlated with ChE (both P <0.05).D-dimer and albumin were correlated with Ch

  15. Delay Adjusted Incidence Infographic

    Science.gov (United States)

    This Infographic shows the National Cancer Institute SEER Incidence Trends. The graphs show the Average Annual Percent Change (AAPC) 2002-2011. For Men, Thyroid: 5.3*,Liver & IBD: 3.6*, Melanoma: 2.3*, Kidney: 2.0*, Myeloma: 1.9*, Pancreas: 1.2*, Leukemia: 0.9*, Oral Cavity: 0.5, Non-Hodgkin Lymphoma: 0.3*, Esophagus: -0.1, Brain & ONS: -0.2*, Bladder: -0.6*, All Sites: -1.1*, Stomach: -1.7*, Larynx: -1.9*, Prostate: -2.1*, Lung & Bronchus: -2.4*, and Colon & Rectum: -3/0*. For Women, Thyroid: 5.8*, Liver & IBD: 2.9*, Myeloma: 1.8*, Kidney: 1.6*, Melanoma: 1.5, Corpus & Uterus: 1.3*, Pancreas: 1.1*, Leukemia: 0.6*, Brain & ONS: 0, Non-Hodgkin Lymphoma: -0.1, All Sites: -0.1, Breast: -0.3, Stomach: -0.7*, Oral Cavity: -0.7*, Bladder: -0.9*, Ovary: -0.9*, Lung & Bronchus: -1.0*, Cervix: -2.4*, and Colon & Rectum: -2.7*. * AAPC is significantly different from zero (p<.05). Rates were adjusted for reporting delay in the registry. www.cancer.gov Source: Special section of the Annual Report to the Nation on the Status of Cancer, 1975-2011.

  16. Metric-adjusted skew information

    DEFF Research Database (Denmark)

    Liang, Cai; Hansen, Frank

    2010-01-01

    We give a truly elementary proof of the convexity of metric-adjusted skew information following an idea of Effros. We extend earlier results of weak forms of superadditivity to general metric-adjusted skew information. Recently, Luo and Zhang introduced the notion of semi-quantum states...... on a bipartite system and proved superadditivity of the Wigner-Yanase-Dyson skew informations for such states. We extend this result to the general metric-adjusted skew information. We finally show that a recently introduced extension to parameter values 1 information is a special case...... of (unbounded) metric-adjusted skew information....

  17. Adjustment computations spatial data analysis

    CERN Document Server

    Ghilani, Charles D

    2011-01-01

    the complete guide to adjusting for measurement error-expanded and updated no measurement is ever exact. Adjustment Computations updates a classic, definitive text on surveying with the latest methodologies and tools for analyzing and adjusting errors with a focus on least squares adjustments, the most rigorous methodology available and the one on which accuracy standards for surveys are based. This extensively updated Fifth Edition shares new information on advances in modern software and GNSS-acquired data. Expanded sections offer a greater amount of computable problems and their worked solu

  18. Variance Adjusted Actor Critic Algorithms

    OpenAIRE

    Tamar, Aviv; Mannor, Shie

    2013-01-01

    We present an actor-critic framework for MDPs where the objective is the variance-adjusted expected return. Our critic uses linear function approximation, and we extend the concept of compatible features to the variance-adjusted setting. We present an episodic actor-critic algorithm and show that it converges almost surely to a locally optimal point of the objective function.

  19. Mood Adjustment via Mass Communication.

    Science.gov (United States)

    Knobloch, Silvia

    2003-01-01

    Proposes and experimentally tests mood adjustment approach, complementing mood management theory. Discusses how results regarding self-exposure across time show that patterns of popular music listening among a group of undergraduate students differ with initial mood and anticipation, lending support to mood adjustment hypotheses. Describes how…

  20. Spousal Adjustment to Myocardial Infarction.

    Science.gov (United States)

    Ziglar, Elisa J.

    This paper reviews the literature on the stresses and coping strategies of spouses of patients with myocardial infarction (MI). It attempts to identify specific problem areas of adjustment for the spouse and to explore the effects of spousal adjustment on patient recovery. Chapter one provides an overview of the importance in examining the…

  1. A complete generalized adjustment criterion

    NARCIS (Netherlands)

    Perković, Emilija; Textor, Johannes; Kalisch, Markus; Maathuis, Marloes H.

    2015-01-01

    Covariate adjustment is a widely used approach to estimate total causal effects from observational data. Several graphical criteria have been developed in recent years to identify valid covariates for adjustment from graphical causal models. These criteria can handle multiple causes, latent confound

  2. Bayes linear covariance matrix adjustment

    CERN Document Server

    Wilkinson, Darren J

    1995-01-01

    In this thesis, a Bayes linear methodology for the adjustment of covariance matrices is presented and discussed. A geometric framework for quantifying uncertainties about covariance matrices is set up, and an inner-product for spaces of random matrices is motivated and constructed. The inner-product on this space captures aspects of our beliefs about the relationship between covariance matrices of interest to us, providing a structure rich enough for us to adjust beliefs about unknown matrices in the light of data such as sample covariance matrices, exploiting second-order exchangeability and related specifications to obtain representations allowing analysis. Adjustment is associated with orthogonal projection, and illustrated with examples of adjustments for some common problems. The problem of adjusting the covariance matrices underlying exchangeable random vectors is tackled and discussed. Learning about the covariance matrices associated with multivariate time series dynamic linear models is shown to be a...

  3. Parental Divorce and Children's Adjustment.

    Science.gov (United States)

    Lansford, Jennifer E

    2009-03-01

    This article reviews the research literature on links between parental divorce and children's short-term and long-term adjustment. First, I consider evidence regarding how divorce relates to children's externalizing behaviors, internalizing problems, academic achievement, and social relationships. Second, I examine timing of the divorce, demographic characteristics, children's adjustment prior to the divorce, and stigmatization as moderators of the links between divorce and children's adjustment. Third, I examine income, interparental conflict, parenting, and parents well-being as mediators of relations between divorce and children's adjustment. Fourth, I note the caveats and limitations of the research literature. Finally, I consider notable policies related to grounds for divorce, child support, and child custody in light of how they might affect children s adjustment to their parents divorce.

  4. Yuan Exchange Rate 'Properly Adjusted'

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

      The currency exchange rate was "properly adjusted" this year and takes into account effects on the country's neighbors and the world, Premier Wen Jiabao said at a regional meeting in Malaysia.……

  5. Adjustment to Spinal Cord Injury

    Science.gov (United States)

    ... may need to work to help with family finances. All of the changes that they face can ... 2000). Goal instability and adjustment to physical disability. Journal of Counseling Psychology, 47(2). 251-265. This ...

  6. Adjustable Induction-Heating Coil

    Science.gov (United States)

    Ellis, Rod; Bartolotta, Paul

    1990-01-01

    Improved design for induction-heating work coil facilitates optimization of heating in different metal specimens. Three segments adjusted independently to obtain desired distribution of temperature. Reduces time needed to achieve required temperature profiles.

  7. Adjustable Chain Trees for Proteins

    DEFF Research Database (Denmark)

    Winter, Pawel; Fonseca, Rasmus

    2012-01-01

    A chain tree is a data structure for changing protein conformations. It enables very fast detection of clashes and free energy potential calculations. A modified version of chain trees that adjust themselves to the changing conformations of folding proteins is introduced. This results in much...... tighter bounding volume hierarchies and therefore fewer intersection checks. Computational results indicate that the efficiency of the adjustable chain trees is significantly improved compared to the traditional chain trees....

  8. Adjustment techniques for experimental data

    International Nuclear Information System (INIS)

    To carry through numerically the different adjustment of experimental data planned by National Institute of Nuclear Research investigators. It is presented the different adjustment techniques of experimental data which are fundamentally for: linear least squares, non linear with restrictions. Methodology: Lineal least squares - Orthogonal decomposition via Householder reflections. No lineal - Method of general lowering and quasi Newton; Levenberg-Marquardt modified - More version. No lineal with restrictions - Quadratic sequential programming method (In process). (Author)

  9. The clinical application of cystatin C, retinol binding protein and D-dimer in preeclampsia diagnosis%子痫前期患者胱抑素C、视黄醇结合蛋白、D-二聚体检测的临床应用研究

    Institute of Scientific and Technical Information of China (English)

    王艳春; 雒雪

    2016-01-01

    目的:探讨胱抑素C(cystatin C, CysC)、视黄醇结合蛋白(retinol binding protein, RBP)、D-二聚体(D-dimer, D-D)在子痫前期患者诊断中的临床应用价值。方法选取我院220例晚期妊娠住院的子痫前期患者为研究对象,分为轻度子痫前期组120例,重度子痫前期组100例,选择同期正常孕妇100例为对照组,检测所有受试者CysC、RBP及D-D的水平,对检测结果进行统计学分析。结果轻度子痫前期组、重度子痫前期组及对照组间CysC、RBP及D-D差异均有统计学意义(P均<0.05);轻度子痫前期组、重度子痫前期组CysC、RBP及D-D检测结果均高于对照组,且差异均具有统计学意义(P均<0.05);轻度子痫前期组CysC、RBP及D-D的检测结果均高于对照组,且差异均有统计学意义(P均<0.05)。结论 CysC、RBP及D-D在子痫前期病情严重程度评估方面有重要的临床参考意义。%Objective To study the clinical application value of cystatin C (CysC), retinol binding protein(RBP) and D-dimer(D-D) in preeclampsia diagnosis. Methods 220 cases patients with preeclamp-sia in our hospital from May 2015 to February 2016 were collected , and were divided into mild preeclampsia group(120 cases), severe preeclampsia group(100 cases). 100 cases normal pregnant women at the same pe-riod were collected as control group. The CysC, RBP and D-D levels of all the subjects were all detected, and the results were analyzed statistically. Results There were statistical significance in the differences of serum CysC, RBP and D-D levels among mild preeclampsia group, severe preeclampsia group and control group (Pall<0.05). The CysC, RBP and D-D levels in mild preeclampsia group and severe preeclampsia group were all higher than that of control group, and the differences all had statistical significance(Pall<0.05). The CysC, RBP and D-D levels in severe preeclampsia group were all

  10. Influence of Chinese traditional medicine Tongmaijiangzhi on blood lipids and D-dimer of the hypercholesterolemia in quails%通脉降脂口服液对高胆固醇血症鹌鹑血脂及D-二聚体水平的影响

    Institute of Scientific and Technical Information of China (English)

    韩桂英; 王婉真; 兴华

    2005-01-01

    BACKGROUND: The incidence and development of atherosclerotic plaque is caused by the disorder of blood coagulation or / and fibrinolysis.The level of blood lipid and D-dimer can reflect the activities of both blood coagulation in vivo and fibrinolysis.OBJECTIVE: To investigate the role of blood lipid , D-dimer level of atherosclerosis in quail model , and the interventional effect of Tongmaijiangzhi , as compared with that of lovatatin.DESIGN: Randomly controlled trial.SETTING: Department of Basic Medicine, Medical College of Zhengzhou Railway Vocational Technology CollegeMATERIALS: This experiment was conducted in the Experimental Center of Medical College of Zhengzhou Railway Vocational Technology College in January 2001. Total 125 quails with body mass varying from 100 to 120 g were selected. The animals were randomly divided into five groups with 25 per group: normal control group, hyperlipidemia group, lovastatin group, hyperlipidemia group with the treatment of low dosage of Tongmaijiangzhi, and hyperlipidemia group with the treatment of high dosage of Tongmaijiangzhi. Blood lipid-depressing medicine Tongmaijiangzhi was extracted from the medicinal herb including chuanxiong rhizome, Chinese angelica root, red sage root notoginseng, oriental water-plantain rhizome,rhubarb, and cassia seed.METHODS: High-fat diet was given the animals in the hyperlipidemia group, lovatatin group, low dosage Tongmaijiangzhi group and treatment high dosage of Tongmaijiangzhi group to establish animals models of quails with hypercholesterolemia, and then the animals in the normal control group and hyperlipidemia group were stomach-perfused with 1.5 mL of distilled water; the animals in the lovatatin group was stomach-perfused with 1.5 mL of lovatatin solution (0.53 g/mL) ; the animals in the low dosage of Tongmaijiangzhi group and high dosage of Tongmaijiangzhi group were stomach-perfused with 1.5 mL of low dosage of Tongmaijiangzhi (1.27 g/mL) and high dosage of Tongmaijiangzhi (2

  11. 7 CFR 251.7 - Formula adjustments.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Formula adjustments. 251.7 Section 251.7 Agriculture... GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION THE EMERGENCY FOOD ASSISTANCE PROGRAM § 251.7 Formula adjustments. Formula adjustments. (a) Commodity adjustments. The Department will make annual adjustments...

  12. Age and smoking-adjusted lung cancer incidence in a Utah county with a steel mill; Incidence du cancer du poumon ajustee sur l'age et le tabagisme dans un comte de l'Utah ou est implantee une acierie

    Energy Technology Data Exchange (ETDEWEB)

    Blindauer, K.M.; Erockson, L.; Mcelwee, N.; Gren, L.H.; Lyon, J.L.

    1999-06-01

    The objectives of the study is the relation between the lung cancer and the atmospheric pollution in the Utah country taking into account the nicotinism and the age. The authors suggest an interaction between the nicotinism and the atmospheric pollution. The method of this study is criticized.

  13. Gestational age

    Science.gov (United States)

    Fetal age - gestational age; Gestation; Neonatal gestational age; Newborn gestational age ... Gestational age can be determined before or after birth. Before birth, your health care provider will use ...

  14. MCCB warm adjustment testing concept

    Science.gov (United States)

    Erdei, Z.; Horgos, M.; Grib, A.; Preradović, D. M.; Rodic, V.

    2016-08-01

    This paper presents an experimental investigation in to operating of thermal protection device behavior from an MCCB (Molded Case Circuit Breaker). One of the main functions of the circuit breaker is to assure protection for the circuits where mounted in for possible overloads of the circuit. The tripping mechanism for the overload protection is based on a bimetal movement during a specific time frame. This movement needs to be controlled and as a solution to control this movement we choose the warm adjustment concept. This concept is meant to improve process capability control and final output. The warm adjustment device design will create a unique adjustment of the bimetal position for each individual breaker, determined when the testing current will flow thru a phase which needs to trip in a certain amount of time. This time is predetermined due to scientific calculation for all standard types of amperages and complies with the IEC 60497 standard requirements.

  15. Covariate-adjusted measures of discrimination for survival data

    DEFF Research Database (Denmark)

    White, Ian R; Rapsomaniki, Eleni; Frikke-Schmidt, Ruth

    2015-01-01

    MOTIVATION: Discrimination statistics describe the ability of a survival model to assign higher risks to individuals who experience earlier events: examples are Harrell's C-index and Royston and Sauerbrei's D, which we call the D-index. Prognostic covariates whose distributions are controlled...... statistics in censored survival data. OBJECTIVE: To develop extensions of the C-index and D-index that describe the prognostic ability of a model adjusted for one or more covariate(s). METHOD: We define a covariate-adjusted C-index and D-index for censored survival data, propose several estimators...... by the study design (e.g. age and sex) influence discrimination and can make it difficult to compare model discrimination between studies. Although covariate adjustment is a standard procedure for quantifying disease-risk factor associations, there are no covariate adjustment methods for discrimination...

  16. Development of postural adjustments during reaching in infants with CP.

    Science.gov (United States)

    Hadders-Algra, M; van der Fits, I B; Stremmelaar, E F; Touwen, B C

    1999-11-01

    The development of postural adjustments during reaching movements was longitudinally studied in seven infants with cerebral palsy (CP) between 4 and 18 months of age. Five infants developed spastic hemiplegia, one spastic tetraplegia, and one spastic tetraplegia with athetosis. Each assessment consisted of a simultaneous recording of video data and surface EMGs of arm, neck, trunk, and leg muscles during reaching in various lying and sitting positions. The basic organization of postural adjustments of the children developing spastic CP was intact. Their main problem was a deficient capacity to modulate the postural adjustments to task-specific constraints - a deficit which was attributed to a combination of an impaired motor coordination and deficits in sensory integration. The child with spastic-dyskinetic CP showed distinct abnormalities in the basic organization of postural adjustments. PMID:10576641

  17. Tax Adjusted for Imported Equipment

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ Ministry of Finance, Central Administration of Customs, and State Administration of Taxation of P.R. of China jointly issued a "Notice on the Lists Related to the Interim Provisions on the Adjustment of Import Tax Policy on Major Technical Equipment" (the Notice) on April 13rd to adjust the list of equipment catalog and merchandise attached to the "Interim Provisions on the Import Tax Policy on Major Technical Equipment", as well as the preferential scope and extent of the import tax on a number of major technical equipment.

  18. Physical Discipline and Children's Adjustment: Cultural Normativeness as a Moderator

    OpenAIRE

    Lansford, Jennifer E.; Chang, Lei; Dodge, Kenneth A.; Malone, Patrick S.; Oburu, Paul; Palmérus, Kerstin; Bacchini, Dario; Pastorelli, Concetta; Bombi, Anna Silvia; Zelli, Arnaldo; Tapanya, Sombat; Chaudhary, Nandita; Deater-Deckard, Kirby; Manke, Beth; Quinn, Naomi

    2005-01-01

    Interviews were conducted with 336 mother – child dyads (children's ages ranged from 6 to 17 years; mothers' ages ranged from 20 to 59 years) in China, India, Italy, Kenya, the Philippines, and Thailand to examine whether normativeness of physical discipline moderates the link between mothers' use of physical discipline and children's adjustment. Multilevel regression analyses revealed that physical discipline was less strongly associated with adverse child outcomes in conditions of greater p...

  19. Development of postural adjustments during reaching in sitting children

    NARCIS (Netherlands)

    van der Heide, JC; Otten, B; van Eykern, LA; Hadders-Algra, M

    2003-01-01

    We evaluated the development of postural adjustments accompanying reaching movements in sitting children. Twenty-nine typically developing children aged, 2-11 years, and ten adults were studied with multiple surface electromyograms (EMGs) and kinematics during reaching in four conditions: sitting wi

  20. Custodial Grandmothers' Psychological Distress, Dysfunctional Parenting, and Grandchildren's Adjustment

    Science.gov (United States)

    Smith, Gregory C.; Palmieri, Patrick A.; Hancock, Gregory R.; Richardson, Rhonda A.

    2008-01-01

    An adaptation of the Family Stress Model (FSM) with hypothesized linkages between family contextual factors, custodial grandmothers' psychological distress, parenting practices, and grandchildren's adjustment was tested with structural equation modeling. Interview data from 733 custodial grandmothers of grandchildren between ages 4-17 revealed…

  1. Development of postural adjustments during reaching in infants with CP

    NARCIS (Netherlands)

    Hadders-Algra, M; van der Fits, IBM; Stremmelaar, EF; Touwen, BCL

    1999-01-01

    The development of postural adjustments during reaching movements was longitudinally studied in seven infants with cerebral palsy (CP) between 4 and 18 months of age. Five infants developed spastic hemiplegia, one spastic tetraplegia, and one spastic tetraplegia with athetosis. Each assessment consi

  2. Social and Psychological Adjustment of Chinese Canadian Children

    Science.gov (United States)

    Chen, Xinyin; Tse, Hennis Chi-Hang

    2010-01-01

    This study examined social and psychological adjustment of immigrant and Canadian-born Chinese children in Canada. Participants included a sample of elementary school children (N = 356, M age = 11 years). Data on social functioning, peer relationships, school-related social competence, perceived self-worth, and loneliness were collected from peer…

  3. Adjustment or updating of models

    Indian Academy of Sciences (India)

    D J Ewins

    2000-06-01

    In this paper, first a review of the terminology used in the model adjustment or updating is presented. This is followed by an outline of the major updating algorithms cuurently available, together with a discussion of the advantages and disadvantages of each, and the current state-of-the-art of this important application and part of optimum design technology.

  4. Self-Adjusting Stack Machines

    CERN Document Server

    Hammer, Matthew A; Chen, Yan; Acar, Umut A

    2011-01-01

    Self-adjusting computation offers a language-based approach to writing programs that automatically respond to dynamically changing data. Recent work made significant progress in developing sound semantics and associated implementations of self-adjusting computation for high-level, functional languages. These techniques, however, do not address issues that arise for low-level languages, i.e., stack-based imperative languages that lack strong type systems and automatic memory management. In this paper, we describe techniques for self-adjusting computation which are suitable for low-level languages. Necessarily, we take a different approach than previous work: instead of starting with a high-level language with additional primitives to support self-adjusting computation, we start with a low-level intermediate language, whose semantics is given by a stack-based abstract machine. We prove that this semantics is sound: it always updates computations in a way that is consistent with full reevaluation. We give a comp...

  5. An adjustable contracted CI method

    Institute of Scientific and Technical Information of China (English)

    王育彬; 甘正汀; 苏克和; 文振翼

    1999-01-01

    A new contracted CI scheme——adjustable contracted CI scheme——is presented and programed. The efficiency of this scheme is tested by some example calculations. The result shows that the application of the new scheme is flexible and the correlation energy loss is lower than that of the original externally contracted CI method.

  6. Adjustment problems and residential care environment

    Directory of Open Access Journals (Sweden)

    Jan Sebastian Novotný

    2015-01-01

    Full Text Available Problem: Residential care environment represents a specific social space that is associated with a number of negative consequences, covering most aspects of children and youth functioning. The paper analyzes of the presence of adjustment problems among adolescents from institutional care environment and compares this results with a population of adolescents who grew up in a family. Methods: The sample consisted of two groups of adolescents. The first group included 285 adolescents currently growing up in an residential care environment, aged 13 to 21 (M = 16.23, SD = 1.643. The second group consisted of 214 adolescents growing up in a family, aged 15 to 20 (M = 17.07, SD = 1.070. We used a questionnaire Youth Self Report. Data were analyzed using descriptive statistics and MANOVA. Results: Results showed that adolescents in residential care exhibit higher average values in all adjustment problems. Also, in the context of diagnostic categories are the residential care adolescents more frequently in non-normal range (borderline and clinical, primarily in the border range. The greatest differences were reflected in the Thought problems and Rule-breaking behavior. MANOVA showed a significant multivariate effect between groups of adolescents, Hotelling's T = .803, F(8, 490 = 49.202, p <.001, d = .445 (large effect. Univariate analysis further showed a significant effect for Withdrawn/depressed (p = .044, d = .089, small effect, Somatic complaints (p = .002, d = .139, medium effect, Social problems (p = 004, d = .127, a small effect, Thought problems (p <.001, d = .633, strong effect, Attention problems (p <.001, d = .320,strong effect, Rule-breaking behavior (p <.001 , d = .383, strong effect, and Aggressive behavior (p = 015, d = .110, small effect. Results for the dimension of Anxious/depressed were not significant (p = .159. Discussion: The results didn’t confirmed the assumption that more than 30% of residential care adolescents have adjustment

  7. Adjustable wheelchair and method for adjusting said adjustable wheelchair, and wheelchair assembly

    NARCIS (Netherlands)

    Oosterhuis, D.S.

    2013-01-01

    The invention relates to an adjustable wheelchair comprising: -a carriage; -two rear wheels; -at least one front wheel; -at least one footrest; -a sub-frame; -a seat; and -a backrest; wherein the two rear wheels, the at least one front wheel and the at least one footrest are mounted to the carriage,

  8. 12 CFR 19.240 - Inflation adjustments.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Inflation adjustments. 19.240 Section 19.240... PROCEDURE Civil Money Penalty Inflation Adjustments § 19.240 Inflation adjustments. (a) The maximum amount... Civil Penalties Inflation Adjustment Act of 1990 (28 U.S.C. 2461 note) as follows: ER10NO08.001 (b)...

  9. [Parental attitude and adjustment to childhood epilepsy].

    Science.gov (United States)

    Ju, S H; Chang, P F; Chen, Y J; Huang, C C; Tsai, J J

    1990-01-01

    Parental attitude and adjustment were examined in 20 epileptic children (ages 6.8-16.6 yrs), using semi-structured interview. The results indicated that parental understandings of epilepsy were generally poor and incorrect. Fifteen (75%) of 20 parents had their own interpretations of causality and 19 (95%) had unrealistic hope for early and complete cure. Parents tended to overprotect and overrestrict their children. Sixteen (80%) concealed the illness for fear of social prejudice, therefore the social support systems were generally poorly utilized. As in other chronic diseases, all parents went through feelings of shock, denial, anger, guilt, fear, anxiety and depression. Family relationships were not affected much, however, poor communications were commonly found between parents and children. Thirteen (65%) parents never talked to their children about epilepsy. We concluded that parents of epileptic children showed negative attitudes toward their children and had difficulties in their psychosocial adjustment probably related to social stigmata and misunderstanding of the illness. Therefore, communication between physician and parents in both medical and psychosocial aspects should be encouraged. PMID:2275364

  10. Multi-toning Image Adjustment

    Institute of Scientific and Technical Information of China (English)

    LIU Shi-guang; WANG Xiao-juan; PENG Qun-sheng

    2011-01-01

    Due to the different lighting environments or other reasons, the pixel colors may be quite different in one image which causes distinct visual discontinuities. It makes the analysis and processing of such an image more difficult and sometime impossible. In this paper, a unified multi-toning image adjustment method is proposed to solve this problem. First, a novel unsupervised clustering method was proposed to partition the source and the target image into a certain number of subsets with similar color statistics. By matching the texture characteristics and luminance distribution between the blocks, it can create optimized correspondence. Then, the color information was transferred from the matched pixels in the source blocks to the target ones. Graph cut method was used to optimize the seams between different subsets in the final step. This method can automatically perform color adjustment of a multi-toning image. It is simple and efficient. Various results show the validity of this method.

  11. Focal Adjustment for Star Tracker

    OpenAIRE

    Liu Hai-bo; Jian-kun Yang; Ji-chun Tan; De-zhi Su; Wen-liang Wang; Xiu-jian Li; Hui Jia

    2010-01-01

    Technique of measuring intensity distribution and size of spot image developed has been discussed, which is especially suitable for defocus adjustment in ground test of star tracker. A novel approach for choosing a proper defocusing position has been proposed based on collimator, Gaussian surface fitting method, and other ordinary instruments. It proves to be practical and adequate in the development of distant object tracking such as star tracker.Defence Science Journal, 2010, 60(6), pp.678-...

  12. Parenting Perfectionism and Parental Adjustment

    OpenAIRE

    Lee, Meghan A.; Schoppe-Sullivan, Sarah J.; Kamp Dush, Claire M.

    2012-01-01

    The parental role is expected to be one of the most gratifying and rewarding roles in life. As expectations of parenting become ever higher, the implications of parenting perfectionism for parental adjustment warrant investigation. Using longitudinal data from 182 couples, this study examined the associations between societal- and self-oriented parenting perfectionism and new mothers’ and fathers’ parenting self-efficacy, stress, and satisfaction. For mothers, societal-oriented parenting perf...

  13. Mexican-origin parents' work conditions and adolescents' adjustment.

    Science.gov (United States)

    Wheeler, Lorey A; Updegraff, Kimberly A; Crouter, Ann

    2015-06-01

    Mexican-origin parents' work experiences are a distal extrafamilial context for adolescents' adjustment. This 2-wave multiinformant study examined the prospective mechanisms linking parents' work conditions (i.e., self-direction, work pressure, workplace discrimination) to adolescents' adjustment (i.e., educational expectations, depressive symptoms, risky behavior) across the transition to high school drawing on work socialization and spillover models. We examined the indirect effects of parental work conditions on adolescent adjustment through parents' psychological functioning (i.e., depressive symptoms, role overload) and aspects of the parent-adolescent relationship (i.e., parental solicitation, parent-adolescent conflict), as well as moderation by adolescent gender. Participants were 246 predominantly immigrant, Mexican-origin, 2-parent families who participated in home interviews when adolescents were approximately 13 and 15 years of age. Results supported the positive impact of fathers' occupational self-direction on all 3 aspects of adolescents' adjustment through decreased father-adolescent conflict, after controlling for family socioeconomic status and earner status, and underemployment. Parental work pressure and discrimination were indirectly linked to adolescents' adjustment, with different mechanisms emerging for mothers and fathers. Adolescents' gender moderated the associations between fathers' self-direction and girls' depressive symptoms, and fathers' experiences of discrimination and boys' risk behavior. Results suggest that Mexican-origin mothers' and fathers' perceptions of work conditions have important implications for multiple domains of adolescents' adjustment across the transition to high school. PMID:25938710

  14. Seat adjustment--capacity and repeatability among occupants in a modern car.

    Science.gov (United States)

    Jonsson, Bertil; Stenlund, Hans; Svensson, Mats Y; Björnstig, Ulf

    2008-02-01

    Families in the Western world have a car and several family members share the same car. In this study, 154 participants have adjusted a driver's seat three times. The primary objective was to study intrapersonal repeatability and intraclass correlation (ICC) on seat; length adjustment, backrest angle, seat front edge and seat rear edge adjustment, related to participant age, sex, stature and weight. Length adjustment has the best intrapersonal repeatability within two repetitions, 49 mm and ICC-value 0.87. Females and younger participants (age < 40 years) adjust seats generally more accurately. Females adjust the seat 41 mm more forward, 120 mm compared to men 79 mm counted from 0-starting position. Females sit with more upright seat backrests, 46 degree compared to 43 degrees for males counted from 0-starting position. Females sit higher than males in both the frontal and rear part of the seat cushion.

  15. Estimation of excess numbers of viral diarrheal cases among children aged <5 years in Beijing with adjusted Serfling regression model%应用调整Serfling回归模型估计北京市5岁以下儿童病毒性腹泻相关超额病例数

    Institute of Scientific and Technical Information of China (English)

    贾蕾; 王小莉; 吴双胜; 马建新; 李洪军; 高志勇; 王全意

    2016-01-01

    Objective To estimate the excess numbers of viral diarrheal cases among children aged <5 years in Beijing from 1 January 2011 to 23 May 2015.Methods The excess numbers of diarrheal cases among the children aged <5 years were estimated by using weekly outpatient visit data from two children' s hospital in Beijing and adjusted Serfling regression model.Results The incidence peaks of viral diarrhea were during 8th-10th week and 40th-42nd week in 2011,40th-4th week in 2012,43rd-49th week in 2013 and 45th week in 2014 to 11th week in 2015 respectively.The excess numbers of viral diarrheal cases among children aged <5 years in the two children's hospital were 911(95%CI:261-1 561),1 998(95%CI:1 250-2 746),1 645 (95%CI:891-2 397),2 806(95%CI:1 938-3 674) and 1 822(95% CI:614-3 031) respectively,accounting for 40.38% (95% CI:11.57%-69.19%),44.21%(95%CI:27.66%-60.77%),45.08%(95%CI:24.42%-65.69%),60.87% (95%CI:42.04%-79.70%) and 66.62% (95%CI:22.45%-110.82%) of total outpatient visits due to diarrhea during 2011-2015,respectively.Totally,the excess number of viral diarrheal cases among children aged <5 years in Beijing was estimated to be 18 731(95%CI:10 106-27 354) from 2011 to 23 May 2015.Conclusions Winter is the season of viral diarrhea for children aged <5 years.The adjusted Serfling regression model analysis suggested that close attention should be paid to the etiologic variation of viruses causing acute gastroenteritis,especially the etiologic variation of norovirus.%目的 构建调整Serf ling回归模型,估计北京市2011年至2015年5月23日病毒性腹泻相关<5岁儿童超额腹泻病例数.方法 利用北京市2家儿童专科医院<5岁儿童急性腹泻周就诊病例数,拟合调整Serf ling回归模型,估计其病毒性腹泻相关超额病例数.结果 北京市2011年第8~10周、40~ 42周,2012年第40~46周,2013年第43~49周,2014年第45周直到2015年第11

  16. Childhood cigarette and alcohol use: Negative links with adjustment.

    Science.gov (United States)

    Staff, Jeremy; Maggs, Jennifer L; Cundiff, Kelsey; Evans-Polce, Rebecca J

    2016-11-01

    Children who initiate cigarette or alcohol use early-during childhood or early adolescence-experience a heightened risk of nicotine and alcohol dependence in later life as well as school failure, crime, injury, and mortality. Using prospective intergenerational data from the Millennium Cohort Study (MCS), we investigate the association between early substance use initiation (cigarettes or alcohol) and age 11 school engagement, academic achievement, and wellbeing. The ongoing MCS tracks the development of a nationally representative sample of children in the United Kingdom (born 2000-2002) from infancy through adolescence. At age 11, MCS children (n=13,221) indicated whether they had ever used cigarettes or alcohol; at age 7 and 11 they reported on school engagement and wellbeing and completed investigator-assessed tests of academic achievement. Using propensity score methods, children who had initiated cigarette or alcohol use by age 11 were matched to abstaining children with similar risks (or propensities) of early substance use, based on numerous early life risk and protective factors assessed from infancy to age 7. We then examined whether early initiators differed from non-initiators in age 11 adjustment and achievement. Results show that substance use by age 11 was uncommon (3% cigarettes; 13% alcohol). After matching for propensity for early initiation, school engagement and wellbeing were significantly lower among initiators compared to non-initiators. Academic achievement was not consistently related to early initiation. We conclude that initiation of smoking and drinking in childhood is associated with poorer adjustment. PMID:27347653

  17. Aging Skin

    Science.gov (United States)

    ... email address Submit Home > Healthy Aging > Wellness Healthy Aging Aging skin More information on aging skin When it ... treated early. Return to top More information on Aging skin Read more from womenshealth.gov Varicose Veins ...

  18. Sierra Leone's Former Child Soldiers: A Follow-Up Study of Psychosocial Adjustment and Community Reintegration

    Science.gov (United States)

    Betancourt, Theresa Stichick; Borisova, Ivelina Ivanova; Williams, Timothy Philip; Brennan, Robert T.; Whitfield, Theodore H.; de la Soudiere, Marie; Williamson, John; Gilman, Stephen E.

    2010-01-01

    This is the first prospective study to investigate psychosocial adjustment in male and female former child soldiers (ages 10-18; n = 156, 12% female). The study began in Sierra Leone in 2002 and was designed to examine both risk and protective factors in psychosocial adjustment. Over the 2-year period of follow-up, youth who had wounded or killed…

  19. Adjustment of Children Born to Teenage Mothers: The Contribution of Risk and Protective Factors.

    Science.gov (United States)

    Dubow, Eric F.; Luster, Tom

    1990-01-01

    Examined contribution of risk and protective factors in adjustment of 721 children, age 8-15, born to teenage mothers. Results showed that exposure to increasing number of risk factors (poverty, urban residence, mother's self-esteem) was associated with greater vulnerability to adjustment problems, while protective factors (intelligence,…

  20. The Impact of Adjustment for Socioeconomic Status on Comparisons of Cancer Incidence between Two European Countries

    Directory of Open Access Journals (Sweden)

    David W. Donnelly

    2013-01-01

    Full Text Available Background. Cancer incidence rates vary considerably between countries and by socioeconomic status (SES. We investigate the impact of SES upon the relative cancer risk in two neighbouring countries. Methods. Data on 229,824 cases for 16 cancers diagnosed in 1995–2007 were extracted from the cancer registries in Northern Ireland (NI and Republic of Ireland (RoI. Cancers in the two countries were compared using incidence rate ratios (IRRs adjusted for age and age plus area-based SES. Results. Adjusting for SES in addition to age had a considerable impact on NI/RoI comparisons for cancers strongly related to SES. Before SES adjustment, lung cancer incidence rates were 11% higher for males and 7% higher for females in NI, while after adjustment, the IRR was not statistically significant. Cervical cancer rates were lower in NI than in RoI after adjustment for age (IRR: 0.90 (0.84–0.97, with this difference increasing after adjustment for SES (IRR: 0.85 (0.79–0.92. For cancers with a weak or nonexistent relationship to SES, adjustment for SES made little difference to the IRR. Conclusion. Socioeconomic factors explain some international variations but also obscure other crucial differences; thus, adjustment for these factors should not become part of international comparisons.

  1. Trustworthiness, Friendships and Self-Control: Factors that Contribute to Young Children's School Adjustment

    Science.gov (United States)

    Betts, Lucy R.; Rotenberg, Ken J.

    2007-01-01

    The aim of present study was to examine the relationship between young children's peer-reported trustworthiness and their school adjustment. Two hundred and eleven (103 male and 108 female) children in the United Kingdom (mean age = 6 years 2 months) took part in this study. Measures of peer-reported trustworthiness, child-rated school adjustment,…

  2. Examining the Components of Children's Peer Liking as Antecedents of School Adjustment

    Science.gov (United States)

    Betts, Lucy R.; Rotenberg, Ken J.; Trueman, Mark; Stiller, James

    2012-01-01

    Children's social interactions with their peers influence their psychosocial adjustment; consequently, the relationship between class-wide peer liking, same-gender peer liking, and school adjustment was explored in two age groups. Peer liking was analysed using the social relations model (SRM). In Study 1, 205 children (103 female and 102 male,…

  3. Adjustment to College in Nonresidential First-Year Students: The Roles of Stress, Family, and Coping

    Science.gov (United States)

    Gefen, Dalia R.; Fish, Marian C.

    2013-01-01

    This study explored factors related to college adjustment in nonresidential first-year students. It was hypothesized that stress, family functioning, and coping strategies would predict academic, personal-emotional, and social adjustment in addition to institutional attachment. The sample comprised 167 first-year college students (ages 18-23)…

  4. Focal Adjustment for Star Tracker

    Directory of Open Access Journals (Sweden)

    Liu Hai-bo

    2010-10-01

    Full Text Available Technique of measuring intensity distribution and size of spot image developed has been discussed, which is especially suitable for defocus adjustment in ground test of star tracker. A novel approach for choosing a proper defocusing position has been proposed based on collimator, Gaussian surface fitting method, and other ordinary instruments. It proves to be practical and adequate in the development of distant object tracking such as star tracker.Defence Science Journal, 2010, 60(6, pp.678-682, DOI:http://dx.doi.org/10.14429/dsj.60.36

  5. A computerized adjustable brain atlas

    International Nuclear Information System (INIS)

    A computerized brain atlas, adjustable to the patients anatomy, has been developed. It is primarily intended for use in positron emission tomography, but may also be employed in other fields utilizing neuro imaging, such as sterotactic surgery, transmission computerized tomography (CT) and magnetic resonance imaging (MRI). The atlas is based on anatomical information obtained from digitized cryosectioned brains. It can be adjusted to fit a wide range of images from individual brains with normal anatomy. The corresponding transformation is chosen so that the modified atlas agrees with a set of CT or NMR images of the patient. The computerized atlas can be used to improve the quantification and evaluation of PET data by: Aiding and improving the selection of regions of interests. Facilitating comparisons of functional image data from different individuals or groups of individuals. Facilitating the comparison of different examinations of the same patient, thus reducing the need of reproducible fixation systems. Providing external a priori anatomical information to be used in the image reconstruction. Improving the attenuation and scatter corrections. Aiding in selecting a suitable patient orientation during the PET study. By applying the inverse atlas transformation to PET data set it is possible to relate the PET information to the anatomy of the reference atlas. Reformatted PET data from different patients can thus be averaged, and averages from different categories of patients can be compared. The method will facilitate the identification of statistically significant differences in the PET information from different groups of patients. (orig.)

  6. Parenting Perfectionism and Parental Adjustment.

    Science.gov (United States)

    Lee, Meghan A; Schoppe-Sullivan, Sarah J; Kamp Dush, Claire M

    2012-02-01

    The parental role is expected to be one of the most gratifying and rewarding roles in life. As expectations of parenting become ever higher, the implications of parenting perfectionism for parental adjustment warrant investigation. Using longitudinal data from 182 couples, this study examined the associations between societal- and self-oriented parenting perfectionism and new mothers' and fathers' parenting self-efficacy, stress, and satisfaction. For mothers, societal-oriented parenting perfectionism was associated with lower parenting self-efficacy, but self-oriented parenting perfectionism was associated with higher parenting satisfaction. For fathers, societal-oriented parenting perfectionism was associated with higher parenting stress, whereas higher levels of self-oriented parenting perfectionism were associated with higher parenting self-efficacy, lower parenting stress, and greater parenting satisfaction. These findings support the distinction between societal- and self-oriented perfectionism, extend research on perfectionism to interpersonal adjustment in the parenting domain, and provide the first evidence for the potential consequences of holding excessively high standards for parenting. PMID:22328797

  7. Research Design in Marital Adjustment Studies.

    Science.gov (United States)

    Croake, James W.; Lyon, Rebecca S.

    1978-01-01

    The numerous marital adjustment studies which exist in the literature are confounded by basic design problems. Marital stability should be the baseline for data. It is then possible to discuss "happiness,""success,""adjustment," and "satisfaction." (Author)

  8. Early educational milestones as predictors of lifelong academic achievement, midlife adjustment, and longevity

    OpenAIRE

    Kern, Margaret L.; Friedman, Howard S

    2008-01-01

    This study gathered follow-up data from the Terman Life Cycle Study (N = 1,023) to examine how age at first reading and age at school entry relate to grade school academic performance, lifelong educational attainment, midlife health and mental adjustment, and longevity across eight decades. Early reading was associated with early academic success, but less lifelong educational attainment and worse midlife adjustment. Early school entry was associated with less educational attainment, worse mi...

  9. Anchoring Adjusted Capital Asset Pricing Model

    OpenAIRE

    Hammad, Siddiqi

    2015-01-01

    An anchoring adjusted Capital Asset Pricing Model (ACAPM) is developed in which the payoff volatilities of well-established stocks are used as starting points that are adjusted to form volatility judgments about other stocks. Anchoring heuristic implies that such adjustments are typically insufficient. ACAPM converges to CAPM with correct adjustment, so CAPM is a special case of ACAPM. The model provides a unified explanation for the size, value, and momentum effects in the stock market. A ke...

  10. Autogenic training as a therapy for adjustment disorder in adolescents

    Directory of Open Access Journals (Sweden)

    Jojić Boris R.

    2005-01-01

    Full Text Available INTRODUCTION Autogenic training is a widespread technique used in psychotherapy. The British school of autogenic training cites a large list of diseases, health states, and life changes, in which autogenic training can be of help. We wanted to explore the application of autogenic training as a therapy for adjustment disorder in adolescents. The sample consisted of a homogeneous group of 31 individuals, with an average age of 17.3±0.2 years, who were diagnosed with adjustment disorder, F 43.2, in accordance with ICD 10 search criteria. OBJECTIVE The aim of our work was to figure out the influence of autogenic training on adjustment disorder, through biophysical and biochemical indicators, and to research the efficacy of autogenic training as a therapy for adjustment disorder in adolescents. METHOD We observed adjustment disorder indicators and their changes in three phases, using initial, final, and control values, which we measured immediately before the beginning, immediately after the completion, and six months after the completion, of the practical course in autogenic training. We measured systolic and diastolic arterial blood pressure, brachial pulse rates, cortisol levels in plasma, cholesterol levels in blood, as well as glucose concentrations. During that period, autogenic training was employed as the sole therapy. RESULTS The study confirmed our preliminary assumptions. The measurements we performed showed that arterial blood pressure, pulse rates, cholesterol and cortisol concentrations, after the application of autogenic training among adolescents suffering from adjustment disorder, were lower than the initial values. They remained lower even six months after the completion of the practical course in autogenic training. CONCLUSION We concluded that autogenic training significantly decreases the values of physiological indicators of adjustment disorder, diminishes the effects of stress in an individual, and eases the adaptation of

  11. Schizotypy and behavioural adjustment and the role of neuroticism.

    Directory of Open Access Journals (Sweden)

    Christoph Völter

    Full Text Available OBJECTIVE: In the present study the relationship between behavioural adjustment following cognitive conflict and schizotypy was investigated using a Stroop colour naming paradigm. Previous research has found deficits with behavioural adjustment in schizophrenia patients. Based on these findings, we hypothesized that individual differences in schizotypy, a personality trait reflecting the subclinical expression of the schizophrenia phenotype, would be associated with behavioural adjustment. Additionally, we investigated whether such a relationship would be explained by individual differences in neuroticism, a non-specific measure of negative trait emotionality known to be correlated with schizotypy. METHODS: 106 healthy volunteers (mean age: 25.1, 60% females took part. Post-conflict adjustment was measured in a computer-based version of the Stroop paradigm. Schizotypy was assessed using the Schizotypal Personality Questionnaire (SPQ and Neuroticism using the NEO-FFI. RESULTS: We found a negative correlation between schizotypy and post-conflict adjustment (r = -.30, p<.01; this relationship remained significant when controlling for effects of neuroticism. Regression analysis revealed that particularly the subscale No Close Friends drove the effect. CONCLUSION: Previous findings of deficits in cognitive control in schizophrenia patients were extended to the subclinical personality expression of the schizophrenia phenotype and found to be specific to schizotypal traits over and above the effects of negative emotionality.

  12. 24 CFR 5.611 - Adjusted income.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Adjusted income. 5.611 Section 5... Serving Persons with Disabilities: Family Income and Family Payment; Occupancy Requirements for Section 8 Project-Based Assistance Family Income § 5.611 Adjusted income. Adjusted income means annual income...

  13. 12 CFR 1780.80 - Inflation adjustments.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Inflation adjustments. 1780.80 Section 1780.80... DEVELOPMENT RULES OF PRACTICE AND PROCEDURE RULES OF PRACTICE AND PROCEDURE Civil Money Penalty Inflation Adjustments § 1780.80 Inflation adjustments. The maximum amount of each civil money penalty within...

  14. Self-adjustable glasses in the developing world

    Directory of Open Access Journals (Sweden)

    Murthy Gudlavalleti VS

    2014-02-01

    Full Text Available Venkata S Murthy Gudlavalleti,1 Komal Preet Allagh,1 Aashrai SV Gudlavalleti2 1Indian Institute of Public Health, Public Health Foundation of India, Hyderabad, 2Centre for Chronic Disease Control, Public Health Foundation of India, New Delhi, India Abstract: Uncorrected refractive errors are the single largest cause of visual impairment globally. Refractive errors are an avoidable cause of visual impairment that are easily correctable. Provision of spectacles is a cost-effective measure. Unfortunately, this simple solution becomes a public health challenge in low- and middle-income countries because of the paucity of human resources for refraction and optical services, lack of access to refraction services in rural areas, and the cost of spectacles. Low-cost approaches to provide affordable glasses in developing countries are critical. A number of approaches has been tried to surmount the challenge, including ready-made spectacles, the use of focometers and self-adjustable glasses, among other modalities. Recently, self-adjustable spectacles have been validated in studies in both children and adults in developed and developing countries. A high degree of agreement between self-adjustable spectacles and cycloplegic subjective refraction has been reported. Self-refraction has also been found to be less prone to accommodative inaccuracy compared with non-cycloplegic autorefraction. The benefits of self-adjusted spectacles include: the potential for correction of both distance and near vision, applicability for all ages, the empowerment of lay workers, the increased participation of clients, augmented awareness of the mechanism of refraction, reduced costs of optical and refraction units in low-resource settings, and a relative reduction in costs for refraction services. Concerns requiring attention include a need for the improved cosmetic appearance of the currently available self-adjustable spectacles, an increased range of correction (currently

  15. Corporal Punishment and Child Adjustment

    Science.gov (United States)

    Aucoin, Katherine J.; Frick, Paul J.; Bodin, S. Doug

    2006-01-01

    The association between corporal punishment and children's emotional and behavioral functioning was studied in a sample of 98 non-referred children with a mean age of 12.35 (SD=1.72) recruited from two school systems in the southeastern United States. Children were divided into those who had experienced no corporal punishment over approximately a…

  16. Do Biomarkers of Inflammation, Monocyte Activation, and Altered Coagulation Explain Excess Mortality Between HIV Infected and Uninfected People?

    Science.gov (United States)

    Tate, Janet P.; Chang, Chung-Chou H.; Butt, Adeel A.; Gerschenson, Mariana; Gibert, Cynthia L.; Leaf, David; Rimland, David; Rodriguez-Barradas, Maria C.; Budoff, Matthew J.; Samet, Jeffrey H.; Kuller, Lewis H.; Deeks, Steven G.; Crothers, Kristina; Tracy, Russell P.; Crane, Heidi M.; Sajadi, Mohammad M.; Tindle, Hilary A.; Justice, Amy C.; Freiberg, Matthew S.

    2016-01-01

    Background: HIV infection and biomarkers of inflammation [measured by interleukin-6 (IL-6)], monocyte activation [soluble CD14 (sCD14)], and coagulation (D-dimer) are associated with morbidity and mortality. We hypothesized that these immunologic processes mediate (explain) some of the excess risk of mortality among HIV infected (HIV+) versus uninfected people independently of comorbid diseases. Methods: Among 2350 (1521 HIV+) participants from the Veterans Aging Cohort Study Biomarker Cohort (VACS BC), we investigated whether the association between HIV and mortality was altered by adjustment for IL-6, sCD14, and D-dimer, accounting for confounders. Participants were followed from date of blood draw for biomarker assays (baseline) until death or July 25, 2013. Analyses included ordered logistic regression and Cox Proportional Hazards regression. Results: During 6.9 years (median), 414 deaths occurred. The proportional odds of being in a higher quartile of IL-6, sCD14, or D-dimer were 2–3 fold higher for viremic HIV+ versus uninfected people. Mortality rates were higher among HIV+ compared with uninfected people [incidence rate ratio (95% CI): 1.31 (1.06 to 1.62)]. Mortality risk increased with increasing quartiles of IL-6, sCD14, and D-dimer regardless of HIV status. Adjustment for IL-6, sCD14, and D-dimer partially attenuated mortality risk among HIV+ people with unsuppressed viremia (HIV-1 RNA ≥10,000 copies per milliliter) compared with uninfected people—hazard ratio (95% CI) decreased from 2.18 (1.60 to 2.99) to 2.00 (1.45 to 2.76). Conclusions: HIV infection is associated with elevated IL-6, sCD14, and D-dimer, which are in turn associated with mortality. Baseline measures of these biomarkers partially mediate excess mortality risk among HIV+ versus uninfected people. PMID:26885807

  17. [Self-concept and psychosocial adjustment in adolescence].

    Science.gov (United States)

    Fuentes, María C; García, José Fernando; Gracia, Enrique; Lila, Marisol

    2011-02-01

    This study analyses the relationship between a multidimensional measure of self-concept, Self-concept Form-5 Questionnaire (AF5), and a broad set of adolescents' psychosocial adjustment indicators. From the responses of 1,281 participants (53.7% females) aged 12 to 17 years ( M = 14.98 years, SD = 1.74 years), results indicated that higher self-concept scores corresponded to better psychological adjustment, good personal skills and fewer behavioral problems. Although a positive relationship between social self-concept and drug use was found, this significant relationship disappeared once the adolescent's age and sex was controlled for. These results support the idea that the self-concept is a basic theoretical construct closely related to the psychosocial adjustment in adolescence. Also this study helps explain some contradictory results reported in the literature (i.e., a positive relationship between social self-concept and drug use), by showing how the statistical control of a third variable effect (i.e., age) avoids reaching conclusions based on spurious relationships.

  18. Early diagnosis of lower extremity deep venous thrombosis and therapeutic effect of anticoagulation therapy with Roberts' age adjusted warfarin loading protocol in patients with acute ischemic stroke%急性脑梗死患者下肢深静脉血栓的诊断及华法林抗凝治疗的疗效和安全性

    Institute of Scientific and Technical Information of China (English)

    罗伟良; 刘武; 邱金华; 许南燕; 李才明; 温红

    2009-01-01

    Objective To explore the early diagnosis of lower extremity deep venous thrombosis (LDVT)and evaluate the therapeutic effect of anticoagulant therapy in hospitalized patients with acute ischemic stroke. Methods According to Wells model for suspecting lower extremity deep venous thrombosis,patients with suspected LDVT were confirmed by compression ultrasonography. If the patients diagnosed with LDVT had no contraindications to anticoagulant therapy,they were treated with low molecular weight heparin(LMWH)subcutaneous injection and oral warfarin at the same time.The dosage of oral warfarin was determined by Roberts'age adjusted warfarin loading protocol.LMWH was stopped when the patients'international normalized ratio(INR)was 2.0~3.0 for two consecutive days. Results From January 2003 to August 2007,2067 cases with acute ischemic stroke were admitted to the department of neurology in Huizhou Municipal Central Hospital including 18 cases with LDVT and the incidence was 0.9%.The patients with LDVT all had paralytic extremities including 13 left legs and 5 right legs with deep vein thrombosis.All the 18 cases were treated by anticoagulant including 17 cases with oral warfarin treatment for 3 months.Symptoms in all LDVT patients were eliminated.12 cases had been observed for one year and 5 cases for three months after they stopped taking warfatin.There were no patients with pulmonary thromboembolism and LDVT recurrence. Conclusions By using Wells model for suspecting LDVT,patients with acute ischemic stroke-complicated LDVT can be timely diagnosed.The goal of prompt and enough anticoagulant can be achieved according to Roberts'age adjusted warfarin loading protocol.Because of racial difference,population difference and other unknown factors,the incidence of acute ischemic stroke patients with complicated LDVT is much lower in Huizhou.It suggests that it should be unnecessary to use LMWH in patients with acute ischemic stroke to prevent LDVT in Huizhou.%目的 探

  19. Effects of Timing of Adversity on Adolescent and Young Adult Adjustment.

    Science.gov (United States)

    Kiff, Cara J; Cortes, Rebecca; Lengua, Lilana; Kosterman, Rick; Hawkins, J David; Mason, W Alex

    2012-06-01

    Effects of Timing of Adversity on Adolescent and Young Adult Adjustment Abstract Exposure to adversity during childhood and adolescence predicts adjustment across development. Further, adolescent adjustment problems persist into young adulthood. This study examined relations of contextual adversity with concurrent adolescent adjustment and prospective mental health and health outcomes in young adulthood. A longitudinal sample (N = 808) was followed from age 10 through 27. Perceptions of neighborhood in childhood predicted depression, alcohol use disorders, and HIV risk in young adulthood. Further, the timing of adversity was important in determining the type of problem experienced in adulthood. Youth adjustment predicted adult outcomes, and in some cases, mediated the relation between adversity and outcomes. These findings support the importance of adversity in predicting adjustment and elucidate factors that affect outcomes into young adulthood. PMID:22754271

  20. Early educational milestones as predictors of lifelong academic achievement, midlife adjustment, and longevity.

    Science.gov (United States)

    Kern, Margaret L; Friedman, Howard S

    2008-01-01

    This study gathered follow-up data from the Terman Life Cycle Study (N = 1,023) to examine how age at first reading and age at school entry relate to grade school academic performance, lifelong educational attainment, midlife health and mental adjustment, and longevity across eight decades. Early reading was associated with early academic success, but less lifelong educational attainment and worse midlife adjustment. Early school entry was associated with less educational attainment, worse midlife adjustment, and most importantly, increased mortality risk. Personality, midlife adjustment, and educational attainment partially mediated the school entry-longevity association (controlling for age, sex, personal characteristics, and home environment factors). Although the sample is limited in some respects and care should be taken in generalizing the results, findings do confirm the importance of lifespan approaches in understanding the effects of education on individual patterns within social contexts. PMID:19626128

  1. Uncertainty in Greenland glacial isostatic adjustment (Invited)

    Science.gov (United States)

    Milne, G. A.; Lecavalier, B.; Kjeldsen, K. K.; Kjaer, K.; Wolstencroft, M.; Wake, L. M.; Simpson, M. J.; Long, A. J.; Woodroffe, S.; Korsgaard, N. J.; Bjork, A. A.; Khan, S. A.

    2013-12-01

    It is well known that the interpretation of geodetic data in Greenland to constrain recent ice mass changes requires knowledge of isostatic land motion associated with past changes in the ice sheet. In this talk we will consider a variety of factors that limit how well the signal due to past mass changes (commonly referred to as glacial isostatic adjustment (GIA)) can be defined. Predictions based on a new model of Greenland GIA will be shown. Using these predictions as a reference, we will consider the influence of plausible variations in some key aspects of both the Earth and ice load components of the GIA model on predictions of land motion and gravity changes. The sensitivity of model output to plausible variations in both depth-dependent and lateral viscosity structure will be considered. With respect to the ice model, we will compare the relative contributions of loading during key periods of the ice history with a focus on the past few thousand years. In particular, we will show predictions of contemporary land motion and gravity changes due to loading changes following the Little Ice Age computed using a new reconstruction of ice thickness changes based largely on empirical data. A primary contribution of this work will be the identification of dominant sources of uncertainty in current models of Greenland GIA and the regions most significantly affected by this uncertainty.

  2. Control of Adjustable Compliant Actuators

    Directory of Open Access Journals (Sweden)

    Berno J.E. Misgeld

    2014-05-01

    Full Text Available Adjustable compliance or variable stiffness actuators comprise an additional element to elastically decouple the actuator from the load and are increasingly applied to human-centered robotic systems. The advantages of such actuators are of paramount importance in rehabilitation robotics, where requirements demand safe interaction between the therapy system and the patient. Compliant actuator systems enable the minimization of large contact forces arising, for example, from muscular spasticity and have the ability to periodically store and release energy in cyclic movements. In order to overcome the loss of bandwidth introduced by the elastic element and to guarantee a higher range in force/torque generation, new actuator designs consider variable or nonlinear stiffness elements, respectively. These components cannot only be adapted to the walking speed or the patient condition, but also entail additional challenges for feedback control. This paper introduces a novel design method for an impedance-based controller that fulfills the control objectives and compares the performance and robustness to a classical cascaded control approach. The new procedure is developed using a non-standard positive-real Η2 controller design and is applied to a loop-shaping approach. Robust norm optimal controllers are designed with regard to the passivity of the actuator load-impedance transfer function and the servo control problem. Classical cascaded and positive-real Η2 controller designs are validated and compared in simulations and in a test bench using a passive elastic element of varying stiffness.

  3. Psychosocial adjustment to recurrent cancer.

    Science.gov (United States)

    Mahon, S M; Cella, D F; Donovan, M I

    1990-01-01

    This descriptive study of the perceptions and needs of people with recurrent malignancies asks three questions: How do patients describe the meaning of a recurrence of cancer? Do individuals perceive the diagnosis of recurrence and the initial diagnosis of cancer differently? What are the key psychosocial problems associated with recurrent cancer? The theoretical framework was based on Lazarus and Folkman's theory of stress, appraisal, and coping. Subjects completed the Impact of Event Scale (IES), the Psychosocial Adjustment to Illness Scale--Self-Report (PAIS), and a semistructured qualitative interview. The interview elicited perceptions of the event of recurrence and differences between the diagnosis of recurrence and the initial diagnosis. The convenience sample included 40 patients diagnosed with recurrent cancer within the last 30 days. Many subjects (78%) reported that the recurrence was more upsetting than the initial diagnosis. Scores on both the IES and the PAIS were high when compared to normative samples of patients with cancer suggesting that this sample of patients experienced a lot of psychological distress as well as problems at home, work, and in their social lives. These concerns often were unknown to caregivers. Although more research is needed, the authors propose that, with more accurate assessment, more effective intervention could be implemented and the quality of life improved for patients with recurrent cancer.

  4. Exploration adjustment by ant colonies.

    Science.gov (United States)

    Doran, Carolina; Stumpe, Martin C; Sendova-Franks, Ana; Franks, Nigel R

    2016-01-01

    How do animals in groups organize their work? Division of labour, i.e. the process by which individuals within a group choose which tasks to perform, has been extensively studied in social insects. Variability among individuals within a colony seems to underpin both the decision over which tasks to perform and the amount of effort to invest in a task. Studies have focused mainly on discrete tasks, i.e. tasks with a recognizable end. Here, we study the distribution of effort in nest seeking, in the absence of new nest sites. Hence, this task is open-ended and individuals have to decide when to stop searching, even though the task has not been completed. We show that collective search effort declines when colonies inhabit better homes, as a consequence of a reduction in the number of bouts (exploratory events). Furthermore, we show an increase in bout exploration time and a decrease in bout instantaneous speed for colonies inhabiting better homes. The effect of treatment on bout effort is very small; however, we suggest that the organization of work performed within nest searching is achieved both by a process of self-selection of the most hard-working ants and individual effort adjustment. PMID:26909180

  5. Predictors of sociocultural adjustment among sojourning Malaysian students in Britain.

    Science.gov (United States)

    Swami, Viren

    2009-08-01

    The process of cross-cultural migration may be particularly difficult for students travelling overseas for further or higher education, especially where qualitative differences exist between the home and host nations. The present study examined the sociocultural adjustment of sojourning Malaysian students in Britain. Eighty-one Malay and 110 Chinese students enrolled in various courses answered a self-report questionnaire that examined various aspects of sociocultural adjustment. A series of one-way analyses of variance showed that Malay participants experienced poorer sociocultural adjustment in comparison with their Chinese counterparts. They were also less likely than Chinese students to have contact with co-nationals and host nationals, more likely to perceive their actual experience in Britain as worse than they had expected, and more likely to perceive greater cultural distance and greater discrimination. The results of regression analyses showed that, for Malay participants, perceived discrimination accounted for the greatest proportion of variance in sociocultural adjustment (73%), followed by English language proficiency (10%) and contact with host nationals (4%). For Chinese participants, English language proficiency was the strongest predictor of sociocultural adjustment (54%), followed by expectations of life in Britain (18%) and contact with host nationals (3%). By contrast, participants' sex, age, and length of residence failed to emerge as significant predictors for either ethnic group. Possible explanations for this pattern of findings are discussed, including the effects of Islamophobia on Malay-Muslims in Britain, possible socioeconomic differences between Malay and Chinese students, and personality differences between the two ethnic groups. The results are further discussed in relation to practical steps that can be taken to improve the sociocultural adjustment of sojourning students in Britain. PMID:22029555

  6. Efficient Adjustable Reflectivity Smart Window

    Energy Technology Data Exchange (ETDEWEB)

    D. Morgan Tench

    2005-12-01

    This project addressed the key technical issues for development of an efficient smart window based on reversible electrochemical transfer of silver between a mirror electrode and a localized counter electrode. Effort to provide uniform switching over large areas focused on use of a resistive transparent electrode innerlayer to increase the interelectrode resistance. An effective edge seal was developed in collaboration with adhesive suppliers and an electrochromic device manufacturer. Work to provide a manufacturable counter electrode focused on fabricating a dot matrix electrode without photolithography by electrodeposition of Pt nuclei on inherent active sites on a transparent oxide conductor. An alternative counter electrode based on a conducting polymer and an ionic liquid electrolyte was also investigated. Work in all of these areas was successful. Sputtered large-bandgap oxide innerlayers sandwiched between conductive indium tin oxide (ITO) layers were shown to provide sufficient cross-layer resistance (>300 ohm/cm{sup 2}) without significantly affecting the electrochemical properties of the ITO overlayer. Two edge seal epoxies, one procured from an epoxy manufacturer and one provided by an electrochromic device manufacturer in finished seals, were shown to be effective barriers against oxygen intrusion up to 80 C. The optimum density of nuclei for the dot matrix counter electrode was attained without use of photolithography by electrodeposition from a commercial alkaline platinum plating bath. Silver loss issues for cells with dot matrix electrodes were successfully addressed by purifying the electrolyte and adjusting the cell cycling parameters. More than 30K cycles were demonstrated for a REM cell (30-cm square) with a dot matrix counter electrode. Larger cells (30-cm square) were successfully fabricated but could not be cycled since the nucleation layers (provided by an outside supplier) were defective so that mirror deposits could not be produced.

  7. Bias Adjusted Precipitation Threat Scores

    Directory of Open Access Journals (Sweden)

    F. Mesinger

    2008-04-01

    Full Text Available Among the wide variety of performance measures available for the assessment of skill of deterministic precipitation forecasts, the equitable threat score (ETS might well be the one used most frequently. It is typically used in conjunction with the bias score. However, apart from its mathematical definition the meaning of the ETS is not clear. It has been pointed out (Mason, 1989; Hamill, 1999 that forecasts with a larger bias tend to have a higher ETS. Even so, the present author has not seen this having been accounted for in any of numerous papers that in recent years have used the ETS along with bias "as a measure of forecast accuracy".

    A method to adjust the threat score (TS or the ETS so as to arrive at their values that correspond to unit bias in order to show the model's or forecaster's accuracy in extit{placing} precipitation has been proposed earlier by the present author (Mesinger and Brill, the so-called dH/dF method. A serious deficiency however has since been noted with the dH/dF method in that the hypothetical function that it arrives at to interpolate or extrapolate the observed value of hits to unit bias can have values of hits greater than forecast when the forecast area tends to zero. Another method is proposed here based on the assumption that the increase in hits per unit increase in false alarms is proportional to the yet unhit area. This new method removes the deficiency of the dH/dF method. Examples of its performance for 12 months of forecasts by three NCEP operational models are given.

  8. An adjustment cost model of distributional dynamics.

    OpenAIRE

    Getachew, Yoseph; Basu, Parantap

    2012-01-01

    We analyze the distributional e¤ects of adjustment cost in an environment with incomplete capital market. We find that a higher adjustment cost for human capital acquisition slows down the intergenerational mobility and results in a persistent inequality across generations. A low depreciation cost of human capital contributes to longer life of the capital which could elevate this adjustment cost and hence contribute to this inequality persistence. A lower total factor productivity could hurt...

  9. Trade Liberalization and Trade Adjustment Assistance

    OpenAIRE

    Fung, K. C.; Staiger, Robert W.

    1994-01-01

    We explore the relationship between trade adjustment subsidies and successful reciprocal trade liberalization. We consider economies that are faced with a periodic need to move resources out of a declining import-competing sector, and that are attempting to sustain cooperative but self-enforcing trade agreements in the face of these adjustment needs. If the limitations associated with enforcement of international trade agreements are sufficiently severe, trade adjustment assistance can facili...

  10. Attitude-adjusting table for neutron monochromator

    International Nuclear Information System (INIS)

    The neutron monochromator attitude-adjusting table is one of the mechanical components for most monochromatic neutron scattering spectrometer. It is mainly used for mounting crystal monochromator, and getting monochromatic neutron by adjusting the attitude of monochromator remotely. The table has a compact volume and five adjusting axes with high resolution. It combines optic mechanical electronic technique with computer control technique. This device will be applied to the neutron residual stress spectrometer on CARR firstly. (authors)

  11. Asian immigrant settlement and adjustment in Australia.

    Science.gov (United States)

    Khoo, S; Kee, P; Dang, T; Shu, J

    1994-01-01

    "This article provides a broad assessment of the settlement and adjustment of people born in the many countries of Asia who are resident in Australia, based on recently available data from the 1991 Census of Population and Housing. It examines some indicators of economic adjustment such as performance in the labor market, and some indicators of social adjustment, such as acquisition of English language proficiency." PMID:12289777

  12. Implementation of Risk Adjustment for Medicare

    OpenAIRE

    Ingber, Melvin J.

    2000-01-01

    The Health Care Financing Administration (HCFA) implemented risk adjustment for Medicare capitated organizations January 2000. The risk adjustment system used, the Principal Inpatient Diagnostic Cost Group (PIPDCG) method, had to be incorporated into the payment structure mandated by the Balanced Budget Act of 1997 (BBA). This article describes how risk adjustment was integrated into the payment system within the rules of the BBA, and how fee-for-service (FFS) and health maintenance organizat...

  13. Rural Aging

    Science.gov (United States)

    ... Rural Health > Topics & States > Topics View more Rural Aging The nation's population is aging, and with that change comes increased healthcare needs. ... Disease Control and Prevention report, The State of Aging and Health in America 2013 , the population 65 ...

  14. How Older Rural Adults Utilize Self-Directed Learning in Late Life Adjustments

    Science.gov (United States)

    Roberson, Donald N., Jr.

    2003-01-01

    The increasing numbers and influence of older adults is causing many segments of western society to re-evaluate the concept of old age. Medical advances and personal lifestyles have resulted in older adults living longer and healthier lives. As one ages, adjustments in work, family, and health must be made. Self-directed learning (SDL) is one way…

  15. Social Networking Site Use Predicts Changes in Young Adults' Psychological Adjustment

    Science.gov (United States)

    Szwedo, David E.; Mikami, Amori Yee; Allen, Joseph P.

    2012-01-01

    This study examined youths' friendships and posted pictures on social networking sites as predictors of changes in their adjustment over time. Observational, self-report, and peer-report data were obtained from a community sample of 89 young adults interviewed at age 21 and again at age 22. Findings were consistent with a leveling effect for…

  16. Early Educational Milestones as Predictors of Lifelong Academic Achievement, Midlife Adjustment, and Longevity

    Science.gov (United States)

    Kern, Margaret L.; Friedman, Howard S.

    2008-01-01

    This study gathered follow-up data from the Terman Life Cycle Study (N = 1023) to examine how age at first reading and age at school entry relate to grade school academic performance, lifelong educational attainment, midlife health and mental adjustment, and longevity across eight decades. Early reading was associated with early academic success,…

  17. Precision Adjustable Liquid Regulator (ALR)

    Science.gov (United States)

    Meinhold, R.; Parker, M.

    2004-10-01

    A passive mechanical regulator has been developed for the control of fuel or oxidizer flow to a 450N class bipropellant engine for use on commercial and interplanetary spacecraft. There are several potential benefits to the propulsion system, depending on mission requirements and spacecraft design. This system design enables more precise control of main engine mixture ratio and inlet pressure, and simplifies the pressurization system by transferring the function of main engine flow rate control from the pressurization/propellant tank assemblies, to a single component, the ALR. This design can also reduce the thermal control requirements on the propellant tanks, avoid costly Qualification testing of biprop engines for missions with more stringent requirements, and reduce the overall propulsion system mass and power usage. In order to realize these benefits, the ALR must meet stringent design requirements. The main advantage of this regulator over other units available in the market is that it can regulate about its nominal set point to within +/-0.85%, and change its regulation set point in flight +/-4% about that nominal point. The set point change is handled actively via a stepper motor driven actuator, which converts rotary into linear motion to affect the spring preload acting on the regulator. Once adjusted to a particular set point, the actuator remains in its final position unpowered, and the regulator passively maintains outlet pressure. The very precise outlet regulation pressure is possible due to new technology developed by Moog, Inc. which reduces typical regulator mechanical hysteresis to near zero. The ALR requirements specified an outlet pressure set point range from 225 to 255 psi, and equivalent water flow rates required were in the 0.17 lb/sec range. The regulation output pressure is maintained at +/-2 psi about the set point from a P (delta or differential pressure) of 20 to over 100 psid. Maximum upstream system pressure was specified at 320 psi

  18. Ratios as a size adjustment in morphometrics.

    Science.gov (United States)

    Albrecht, G H; Gelvin, B R; Hartman, S E

    1993-08-01

    Simple ratios in which a measurement variable is divided by a size variable are commonly used but known to be inadequate for eliminating size correlations from morphometric data. Deficiencies in the simple ratio can be alleviated by incorporating regression coefficients describing the bivariate relationship between the measurement and size variables. Recommendations have included: 1) subtracting the regression intercept to force the bivariate relationship through the origin (intercept-adjusted ratios); 2) exponentiating either the measurement or the size variable using an allometry coefficient to achieve linearity (allometrically adjusted ratios); or 3) both subtracting the intercept and exponentiating (fully adjusted ratios). These three strategies for deriving size-adjusted ratios imply different data models for describing the bivariate relationship between the measurement and size variables (i.e., the linear, simple allometric, and full allometric models, respectively). Algebraic rearrangement of the equation associated with each data model leads to a correctly formulated adjusted ratio whose expected value is constant (i.e., size correlation is eliminated). Alternatively, simple algebra can be used to derive an expected value function for assessing whether any proposed ratio formula is effective in eliminating size correlations. Some published ratio adjustments were incorrectly formulated as indicated by expected values that remain a function of size after ratio transformation. Regression coefficients incorporated into adjusted ratios must be estimated using least-squares regression of the measurement variable on the size variable. Use of parameters estimated by any other regression technique (e.g., major axis or reduced major axis) results in residual correlations between size and the adjusted measurement variable. Correctly formulated adjusted ratios, whose parameters are estimated by least-squares methods, do control for size correlations. The size-adjusted

  19. 75 FR 59684 - Trade Adjustment Assistance for Farmers

    Science.gov (United States)

    2010-09-28

    ... Foreign Agricultural Service Trade Adjustment Assistance for Farmers AGENCY: Foreign Agricultural Service... analyzed by USDA's Economic Research Service and reviewed by the Trade Adjustment Assistance for Farmers... adjustment assistance in FY 2011. FOR FURTHER INFORMATION CONTACT: Trade Adjustment Assistance for...

  20. Intimate partner violence, coercive control, and child adjustment problems.

    Science.gov (United States)

    Jouriles, Ernest N; McDonald, Renee

    2015-02-01

    Coercive control is a relationship dynamic that is theorized to be key for understanding physical intimate partner violence (IPV). This research examines how coercive control in the context of physical IPV may influence child adjustment. Participants were 107 mothers and their children, aged 7 to 10 years. In each family, mothers reported the occurrence of at least one act of physical IPV in the past 6 months. Mothers reported on physical IPV and coercive control, and mothers and children reported on children's externalizing and internalizing problems. Coercive control in the context of physical IPV related positively with both mothers' and children's reports of child externalizing and internalizing problems, after accounting for the frequency of physical IPV, psychological abuse, and mothers' education. This research suggests that couple relationship dynamics underlying physical IPV are potentially important for understanding how physical IPV leads to child adjustment problems. PMID:24923886

  1. Adjustment of the Internal Tax Scale

    CERN Multimedia

    2013-01-01

    In application of Article R V 2.03 of the Staff Regulations, the internal tax scale has been adjusted with effect on 1 January 2012. The new scale may be consulted via the CERN Admin e-guide.  The notification of internal annual tax certificate for the financial year 2012 takes into account this adjustment. HR Department (Tel. 73907)

  2. 24 CFR 886.112 - Rent adjustments.

    Science.gov (United States)

    2010-04-01

    ... Adjustment Factor most recently published by HUD in the Federal Register in accordance with 24 CFR part 888... unassisted housing in the area to ensure that adjustments in the Contract Rents shall not result in material differences between the rents charged for assisted and comparable unassisted units. Contract Rents may...

  3. 7 CFR 1744.64 - Budget adjustment.

    Science.gov (United States)

    2010-01-01

    ... another source, requests a deficiency loan, or scales back the project. (b) RUS may make a budget... AGRICULTURE POST-LOAN POLICIES AND PROCEDURES COMMON TO GUARANTEED AND INSURED TELEPHONE LOANS Advance and... description of how the adjustment will affect loan purposes. RUS will not approve a budget adjustment...

  4. Divorcing Parents: Guidelines for Promoting Children's Adjustment.

    Science.gov (United States)

    Freeman, Kurt A.; Adams, Christina D; Drabman, Ronald S.

    1998-01-01

    There are measures that parents can take to help their children through the often distressing process of parental divorce. Describes the empirical literature regarding issues and factors relevant to children's adjustment to divorce. Provides practical guidelines and suggestions likely to help parents enhance their children's adjustment.…

  5. Research on Adjust Time of Premium

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    By considering economic strength and economic profit of insurance company, this paper presents a concept-contact point, and gives premium expectation adjust time model which provides more practical significance for insurance company to make rational adjustment of premium. Finally, an illustration is given to show their application.

  6. 10 CFR 905.34 - Adjustment provisions.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Adjustment provisions. 905.34 Section 905.34 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Power Marketing Initiative § 905.34 Adjustment... continue to take place based on existing contract/marketing criteria principles....

  7. 34 CFR 36.2 - Penalty adjustment.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Penalty adjustment. 36.2 Section 36.2 Education Office of the Secretary, Department of Education ADJUSTMENT OF CIVIL MONETARY PENALTIES FOR INFLATION § 36.2... applicable) penalty amount 20 U.S.C. 1015(c)(5) Provides for a fine of up to $25,000 for failure by...

  8. A Digital Game for International Students' Adjustment

    Science.gov (United States)

    Bisadi, Maryam; Chua, Alton Y. K; Keong, Lee Chu

    2013-01-01

    Although digital games have been developed for various subject areas, little attention has been focused on using digital games to address international students' adjustment issues. For this reason, this paper endeavors to explore the use of a digital game in facilitating international students acquire adjustment-related information. Specifically,…

  9. Adjusting to Retirement: Considerations for Counselors.

    Science.gov (United States)

    LaBauve, Bill J.; Robinson, Chester R.

    1999-01-01

    Examines retirement, while focusing on issues older adults face in adjusting to retirement, and suggests implications for counseling people who are making this transition. Discusses adjustment to retirement in terms of role, disengagement, activity, continuity, crisis, and compromise/negotiation theories. (Author/MKA)

  10. Redox theory of aging

    Directory of Open Access Journals (Sweden)

    Dean P. Jones

    2015-08-01

    Full Text Available Metazoan genomes encode exposure memory systems to enhance survival and reproductive potential by providing mechanisms for an individual to adjust during lifespan to environmental resources and challenges. These systems are inherently redox networks, arising during evolution of complex systems with O2 as a major determinant of bioenergetics, metabolic and structural organization, defense, and reproduction. The network structure decreases flexibility from conception onward due to differentiation and cumulative responses to environment (exposome. The redox theory of aging is that aging is a decline in plasticity of genome–exposome interaction that occurs as a consequence of execution of differentiation and exposure memory systems. This includes compromised mitochondrial and bioenergetic flexibility, impaired food utilization and metabolic homeostasis, decreased barrier and defense capabilities and loss of reproductive fidelity and fecundity. This theory accounts for hallmarks of aging, including failure to maintain oxidative or xenobiotic defenses, mitochondrial integrity, proteostasis, barrier structures, DNA repair, telomeres, immune function, metabolic regulation and regenerative capacity.

  11. Attachment for sucker rod depth adjustment

    Energy Technology Data Exchange (ETDEWEB)

    Collins, N.D.

    1992-04-07

    This patent describes a surface unit of an oil well pumping system, having a walking beam, a suspended carrier bar and an interconnected sucker rod assembly for stroking a reciprocating down-hole pump. It comprises a cross bar having a centrally located passage therein for the sucker rod assembly and adapted to be transversely supported by the carrier bar; a depth adjusting bar, having a centrally located passage therein for the sucker rod assembly, positioned at a selected fixed dimension above and parallel to the cross bar and adapted to operatively support the sucker rod assembly; clamping means for fixing the sucker rod relative to the depth adjusting bar; and hydraulically extendable means supportively connecting the depth adjusting bar to the cross bar on at least each side of the carrier bar for adjusting the selected fixed dimension and maintaining the adjustment during operation.

  12. 75 FR 33379 - Railroad Cost Recovery Procedures-Productivity Adjustment; Quarterly Rail Cost Adjustment Factor

    Science.gov (United States)

    2010-06-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Railroad Cost Recovery Procedures--Productivity Adjustment; Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board. ] ACTION: Notice and request for...

  13. Perceived age is associated with bone status in women aged 25-93 years

    DEFF Research Database (Denmark)

    Nielsen, Barbara Rubek; Linneberg, Allan; Christensen, Kaare;

    2015-01-01

    with the hypothesis (e.g., β -0.29 %; 95 % confidence interval (CI) 0.55, 0.03). Statistical significance of the association of age-adjusted facial RPACA with BMD was found. Adjusted for body mass index (BMI), menopause, and hormone replacement therapy, higher RPACA from all photographic presentations were...... for chronological age. This is a cross-sectional study of 460 women aged 25-93 years. BMD/TBS was measured. Twenty physicians assessed age from facial and whole-body photographs. Residual PA (RPACA) was calculated from the regression of PA on chronological age. Participants were divided into "looking old" (LO...

  14. Is Emotional Adjustment Status Predictor of the IUD Survival?

    Directory of Open Access Journals (Sweden)

    Ziba Farajzadegan

    2009-03-01

    Full Text Available Objective: To evaluate the effect of emotional adjustment on IUD continuation to understand why persons with similar clinical problems have different interpretation and select different strategies to cope with their complaints.Materials and Methods: This historical cohort study was carried out on 12 randomly chosen health centers of Isfahan province in 2007. Two hundred forty eight literate and married women aged 15-49 years who had chosen IUD as a contraceptive method since 2002 entered the study. After explaining the aim of study and taking informed consent, women completed the demographic, individual characteristics and 32 questions in emotional domain of Bell’s Adjustment Inventory (adult form. May 2007 was considered the end time of IUD consumption as a defined outcome. Data analysis was performed with the SPSS version 15. T–test, chi–square, Mann–Whitney, General Linear Model, Regression were used for data analysis.Results: During this period 60% (146 of women preserved their IUD and 40% (98 of them removed their IUD. The mean score of emotional adjustment was 16.16±6.28 in IUD preserved women in comparison to 18.23±5.63 in IUD removed women. Poor ,moderate and good  grades of emotional adjustment were 54%, 40% and 6% in IUD preserved woman vs 72.4% , 24.5% and 3.1% in IUD removed women.Conclusion: Psychological factors such as emotional adjustment can influence IUD survival; so improved counseling and good candidate selection before IUD insertion is recommended.

  15. Genetic evaluation of beef carcass data using different endpoint adjustments.

    Science.gov (United States)

    Rumph, J M; Shafer, W R; Crews, D H; Enns, R M; Lipsey, R J; Quaas, R L; Pollak, E J

    2007-05-01

    Carcass data from 6,795 Simmental-sired animals born from 1992 to 2001 were used to determine whether adjustment to a constant age, back-fat, HCW, or marbling score would result in differences in heritability of the carcass traits and, correspondingly, if EPD calculated using those variance components and adjustments would result in sire reranking. The endpoints were age (EPA), backfat (EPF), HCW (EPC), or marbling (EPM). The traits analyzed were 12th-rib backfat (FAT), HCW, marbling (MRB), LM area (LMA), and percentage retail cuts (PRC). The data were analyzed using an animal model, where contemporary group was included as a fixed effect and was composed of slaughter date, sex, and herd. Random effects included in the model were direct genetic and residual. Estimates of heritability ranged from 0.12 to 0.14, 0.32 to 0.34, and 0.26 to 0.27 for FAT, HCW, and LMA, respectively, for the corresponding endpoints. Heritability for MRB was estimated to be 0.27 at all endpoints. For PRC, estimates of heritability were more variable, with estimates of 0.23 +/- 0.05, 0.32 +/- 0.05, 0.21 +/- 0.05, and 0.20 +/- 0.04 for EPA, EPF, EPC, and EPM, respectively. However, because the EPF and EPC adjustments adjust for a component trait of PRC (FAT and HCW, respectively), they may be altering the trait to one different from PRC. Spearman rank correlations between EPD within a trait using EPA compared with the other endpoints were >0.90 (P < 0.01) for FAT, HCW, MRB, and LMA. For PRC, Spearman rank correlations with EPA EPD were 0.73 (P < 0.01), 0.93 (P < 0.01), and 0.95 (P < 0.01) for EPF, EPC, and EPM, respectively. For most traits and endpoints, there was little reranking among sires when alternative endpoints were used. However, adjusting PRC to EPF appears to result in a greater heritability and substantial re-ranking of sires, potentially due to the adjustment changing the trait to one other than PRC. PMID:17224467

  16. Arterial Ageing

    OpenAIRE

    Lee, Seung-Jun; Park, Sung-Ha

    2013-01-01

    Arterial ageing is characterized by age associated degeneration and sclerosis of the media layer of the large arteries. However, besides ageing, clinical conditions, which enhance oxidative stress and inflammation act to accelerate the degree of arterial ageing. In this review, we summarized the pathophysiology and contributing factors that accelerate arterial ageing. Among them, we focused on hypertension, the renin-angiotensin-aldosterone system and vascular inflammation which are modifiabl...

  17. Being out at school: the implications for school victimization and young adult adjustment.

    Science.gov (United States)

    Russell, Stephen T; Toomey, Russell B; Ryan, Caitlin; Diaz, Rafael M

    2014-11-01

    Many lesbian, gay, bisexual, and transgender (LGBT) adolescents disclose their sexual and/or gender identities to peers at school. Disclosure of LGBT status is linked with positive psychosocial adjustment for adults; however, for adolescents, "coming out" has been linked to school victimization, which in turn is associated with negative adjustment. This study investigates the associations among adolescent disclosure of LGBT status to others at school, school victimization, and young adult psychosocial adjustment using a sample of 245 LGBT young adults (aged 21-25 years, living in California). After accounting for the association between school victimization and later adjustment, being out at high school was associated with positive psychosocial adjustment in young adulthood. Results have significant implications for training of school-based health and mental health providers, education and guidance for parents and caregivers, fostering positive development of LGBT youth, and developing informed school policies and educational practices.

  18. Effects of multiple context and cumulative stress on urban children's adjustment in elementary school.

    Science.gov (United States)

    Morales, Julie R; Guerra, Nancy G

    2006-01-01

    Using longitudinal data collected over 2 years on a sample of 2,745 urban elementary school children (1st-6th graders, ages 6-11 years) from economically disadvantaged communities, effects of stressful experiences within 3 contexts (school, family, neighborhood), cumulative stress, and multiple context stress on 3 indices of children's adjustment (achievement, depression, and aggression) were examined. All 3 stressor contexts were related contemporaneously and longitudinally to negative outcomes across adjustment measures, with differential paths in each predictive model. Cumulative stress was linearly related to increases in adjustment problems but multiple context stress was not related to problematic adjustment beyond effects of cumulative stress alone. The important influence of life events stress on children's adjustment in disadvantaged communities is discussed.

  19. Being out at school: the implications for school victimization and young adult adjustment.

    Science.gov (United States)

    Russell, Stephen T; Toomey, Russell B; Ryan, Caitlin; Diaz, Rafael M

    2014-11-01

    Many lesbian, gay, bisexual, and transgender (LGBT) adolescents disclose their sexual and/or gender identities to peers at school. Disclosure of LGBT status is linked with positive psychosocial adjustment for adults; however, for adolescents, "coming out" has been linked to school victimization, which in turn is associated with negative adjustment. This study investigates the associations among adolescent disclosure of LGBT status to others at school, school victimization, and young adult psychosocial adjustment using a sample of 245 LGBT young adults (aged 21-25 years, living in California). After accounting for the association between school victimization and later adjustment, being out at high school was associated with positive psychosocial adjustment in young adulthood. Results have significant implications for training of school-based health and mental health providers, education and guidance for parents and caregivers, fostering positive development of LGBT youth, and developing informed school policies and educational practices. PMID:25545431

  20. Cross-Cultural Adjustment of Chinese Students in Japan: School Adjustment and Educational Support

    Science.gov (United States)

    Li, Yuan Xiang; Sano, Hideki; Ahn, Ruth

    2013-01-01

    This study investigates Chinese immigrant students' cross-cultural and school adjustment issues in Japanese schools. Using a quantitative method, a survey which collected students' demographic information, cross-cultural adjustment, and school adjustment questions was administered to 143 Chinese junior high and high school students in…

  1. Maternal adjustment and maternal attitudes in adolescent and adult pregnant women

    OpenAIRE

    Figueiredo, Bárbara; Tendais, Iva; Dias, Cláudia Castro

    2014-01-01

    Study Objective: This study analyzes differences between adolescent and adult pregnant women and the contribution of maternal age to maternal adjustment and maternal attitudes during pregnancy. Design, Setting, and Participants: A sample of 398 Portuguese pregnant women (111 younger than 19 years) was recruited in a Portuguese Maternity Hospital and completed the Maternal Adjustment and Maternal Attitudes Questionnaire between the 24th and 36th weeks of gestation. Main Outcome Measures: Mater...

  2. Language Brokering Contexts and Behavioral and Emotional Adjustment among Latino Parents and Adolescents

    OpenAIRE

    Martinez, Charles R.; McClure, Heather H.; Eddy, J. Mark

    2009-01-01

    This study examined behavioral and emotional adjustment in family contexts in which there was high versus low demand for adolescents to serve as language brokers in a sample of 73 recently immigrated Latino families with middle-school-aged adolescents. Language brokering was conceptualized as a family process rather than merely an individual phenomenon. Multiple agents were used to assess language brokering and parent and youth adjustment. Results indicated that high language brokering contex...

  3. Role of Osmotic Adjustment in Plant Productivity

    Energy Technology Data Exchange (ETDEWEB)

    Gebre, G.M.

    2001-01-11

    Successful implementation of short rotation woody crops requires that the selected species and clones be productive, drought tolerant, and pest resistant. Since water is one of the major limiting factors in poplar (Populus sp.) growth, there is little debate for the need of drought tolerant clones, except on the wettest of sites (e.g., lower Columbia River delta). Whether drought tolerance is compatible with productivity remains a debatable issue. Among the many mechanisms of drought tolerance, dehydration postponement involves the maintenance of high leaf water potential due to, for example, an adequate root system. This trait is compatible with productivity, but requires available soil moisture. When the plant leaf water potential and soil water content decline, the plant must be able to survive drought through dehydration tolerance mechanisms, such as low osmotic potential or osmotic adjustment. Osmotic adjustment and low osmotic potential are considered compatible with growth and yield because they aid in the maintenance of leaf turgor. However, it has been shown that turgor alone does not regulate cell expansion or stomatal conductance and, therefore, the role of osmotic adjustment is debated. Despite this finding, osmotic adjustment has been correlated with grain yield in agronomic crop species, and gene markers responsible for osmotic adjustment are being investigated to improve drought tolerance in productive progenies. Although osmotic adjustment and low osmotic potentials have been investigated in several forest tree species, few studies have investigated the relationship between osmotic adjustment and growth. Most of these studies have been limited to greenhouse or container-grown plants. Osmotic adjustment and rapid growth have been specifically associated in Populus and black spruce (Picea mariuna (Mill.) B.S.P.) progenies. We tested whether these relationships held under field conditions using several poplar clones. In a study of two hybrid poplar

  4. Experiment on performance of adjustable jet pump

    International Nuclear Information System (INIS)

    When the water level of upper or lower reaches of hydraulic power station changes, the adjustable jet pump which is different from traditional fixed jet pump can maintain stable pressure and flow rate for the system of technical water supply of hydraulic power plant. The model test indicates that the efficiency of the adjustable jet pump is slightly lower than fixed jet pump near rating operation point. With the decrease of opening degree, both efficiencies are more and more close to each other. The fundamental performance of I-type adjustable jet pump is better than II-type and the cavitation performance of I-type adjustable jet pump is worse than II-type. Test data also indicate that the performance of adjustable jet pump is very different from fixed jet pump, so the theory of fixed jet pump is not able to be copied to adjustable jet pump. It is necessary to farther study on the performance of the adjustable jet pump. This paper has reference value for analogous design of system of circulation water supply to turbine units in hydraulic power station.

  5. Adjustment and mental health problem in prisoners

    Directory of Open Access Journals (Sweden)

    Sudhinta Sinha

    2010-01-01

    Full Text Available Background : "Crime" is increasing day by day in our society not only in India but also all over the world. In turn, the number of prisoners is also increasing at the same rate. They remain imprisoned for a long duration or in some cases for the whole life. Living in a prison for long time becomes difficult for all inmates. So they often face adjustment and mental health problems. Recent findings suggest that mental illness rate in prison is three times higher than in the general population. Objective: The aim of the present study was to investigate the adjustment and the mental health problem and its relation in the prisoners. Materials and Methods : In the present study, 37 male prisoners of district jail of Dhanbad District of Jharkhand were selected on purposive sampling basis. Each prisoner was given specially designed Performa - Personal Data Sheet, General Health Questionnaire-12 and Bell Adjustment Inventory. Appropriate statistical tools were used to analyze the data. Results: The results obtained showed poor adjustment in social and emotional areas on the adjustment scale. The study also revealed a significant association between adjustment and mental health problem in the prisoners. Conclusion: The prisoners were found to have poor social and emotional adjustment which has strong association with their mental health.

  6. Structural Adjustment of Oasis Agriculture in Xinjiang

    Institute of Scientific and Technical Information of China (English)

    Lei Jun; Zhang Xiaolei

    2005-01-01

    Xinjiang's oasis agriculture has made enormous strides over past decades. Structural adjustment of oasis agriculture sector has promoted production diversification. Xinjiang's oasis agriculture sector is entering a new era. The era means more adjustments in oasis agricultural and rural economic structure so as to realize the sustainable development of agriculture. By summing and analyzing the main problems in Xinjinag's oasis agricultural structure,such as raising farmer's income, industry structure within agriculture, rural urbanization, pressure coming from market, agricultural environment degradation,puts forward the thinking, director and countermeasures to adjust oasis agricultural structure.

  7. A note on how to iterate adjustment

    Energy Technology Data Exchange (ETDEWEB)

    Wagschal, Jehudah J.; Yeivin, Yehuda [Hebrew University of Jerusalem, Racah Institute of Physics, Jerusalem (Israel)

    2002-08-01

    We study the elementary problem of adjusting a given parameter library by one measured response so that calculating the response with the adjusted library reproduces the measured value. We formulate the problem of the least-squares adjustment for non-linear responses, and offer a reasoned iteration scheme to solve it. A numerical example illustrates the success of the proposed procedure. Our scheme is identical to that suggested by Perey, and thus adds insight, offers justification, and also serves as a formal proof of the latter. (author)

  8. Stress and Personal Resource as Predictors of the Adjustment of Parents to Autistic Children: A Multivariate Model

    Science.gov (United States)

    Siman-Tov, Ayelet; Kaniel, Shlomo

    2011-01-01

    The research validates a multivariate model that predicts parental adjustment to coping successfully with an autistic child. The model comprises four elements: parental stress, parental resources, parental adjustment and the child's autism symptoms. 176 parents of children aged between 6 to 16 diagnosed with PDD answered several questionnaires…

  9. Cultural Identity, Perceived Discrimination, and Parental Support as Determinants of Immigrants' School Adjustments: Vietnamese Youth in Finland

    Science.gov (United States)

    Liebkind, Karmela; Jasinskaja-Lahti, Inga; Solheim, Erling

    2004-01-01

    This study focuses on factors predicting school adjustment of immigrant adolescents. One hundred seventy-five immigrant adolescents of Vietnamese origin in Finland (ages 13 to 18) were compared with a sample of host national Finnish youth (N = 337). The immigrant adolescents were better adjusted to school than were their host national peers. In…

  10. Functional ability at age 75: is there an impact of physical inactivity from middle age to early old age?

    DEFF Research Database (Denmark)

    Christensen, Ulla; Støvring, N; Schultz-Larsen, K;

    2006-01-01

    The aim of this study is to analyze the impact of physical inactivity from middle age to early old age on functional ability at age 75. Physical activity is measured both as cumulated activity from age 50 to 60 to 70 and at three separate points in time. Three hundred eighty-seven men and women...... inactivity from age 50 to 60 to 70 on disability at age 75 when adjusting for functional ability at age 70. Physical inactivity is a risk factor for disability among old people. Thus, old people should be encouraged to take up and maintain physical training throughout the aging process.......) and smoking, sex, school education, household composition, chronic disease at baseline and functional ability at age 70 as possible confounders. There was a strong association between physical inactivity at age 70 and disability at age 75. However, the analyses showed no effect of cumulated physical...

  11. Happy Aging

    Institute of Scientific and Technical Information of China (English)

    梁秉中

    2009-01-01

    Aging is a normal physiological process in human life.The decline in the ability to repair and regenerate predisposes the aging person to develop disabling problems in the cardiovascular and skeletal systems.Full awareness of aging problems and advocations on the means to prevent their occurrence are mounting.European and US groups rely on scientific,target-oriented means to treat aging manifestations. Oriental medicine aims at prevention,using nutrition and exercise to maintain internal harmony.

  12. Population Aging

    OpenAIRE

    Weil, David N.

    2006-01-01

    Population aging is primarily the result of past declines in fertility, which produced a decades long period in which the ratio of dependents to working age adults was reduced. Rising old-age dependency in many countries represents the inevitable passing of this %u201Cdemographic dividend.%u201D Societies use three methods to transfer resources to people in dependent age groups: government, family, and personal saving. In developed countries, families are predominant in supporting children, w...

  13. Overpaying morbidity adjusters in risk equalization models.

    Science.gov (United States)

    van Kleef, R C; van Vliet, R C J A; van de Ven, W P M M

    2016-09-01

    Most competitive social health insurance markets include risk equalization to compensate insurers for predictable variation in healthcare expenses. Empirical literature shows that even the most sophisticated risk equalization models-with advanced morbidity adjusters-substantially undercompensate insurers for selected groups of high-risk individuals. In the presence of premium regulation, these undercompensations confront consumers and insurers with incentives for risk selection. An important reason for the undercompensations is that not all information with predictive value regarding healthcare expenses is appropriate for use as a morbidity adjuster. To reduce incentives for selection regarding specific groups we propose overpaying morbidity adjusters that are already included in the risk equalization model. This paper illustrates the idea of overpaying by merging data on morbidity adjusters and healthcare expenses with health survey information, and derives three preconditions for meaningful application. Given these preconditions, we think overpaying may be particularly useful for pharmacy-based cost groups. PMID:26420555

  14. Price adjustments by a gasoline retail chain

    International Nuclear Information System (INIS)

    We use daily data to examine price responses in the Swedish gasoline market to changes in the Rotterdam spot price, exchange rates and taxes. The distribution of price adjustments by a leading retail chain, for the period January 1980 to December 1996, is symmetric with no small adjustments. An error correction model shows that, in the short run, prices gradually move towards the long-run equilibrium in response to cost shocks. There is some evidence that, also in the short run, prices are stickier downwards than upwards. Prices respond more rapidly to exchange rate movements than to the spot market price. Our analysis emphasizes that to fully understand price adjustments it is necessary to examine data sets where the sample frequency at least matches that of price adjustments

  15. Speed of adjustment: Evidence from Borsa Istanbul

    Directory of Open Access Journals (Sweden)

    Emrah Arioglu

    2014-06-01

    Full Text Available In this study, we investigate the speed of adjustment for leverage ratios of firms listed on Borsa Istanbul, in order to investigate the prediction of the trade-off theory, regarding capital structure rebalancing. For this purpose, we estimate the speed of adjustment by using Generalized Method of Moments system estimation technique. The results of this estimation suggest the speed of adjustment as approximately 29%. This significant speed of adjustment is consistent with the prediction of trade-off theory, which suggests that firms follow target capital structures and when the firms' leverage ratios deviate from these targets; they make financial decisions with the goal of closing the gap between the previous year's leverage and target leverage of the current period.

  16. Annual adjustments to 2014 financial benefits

    CERN Multimedia

    2013-01-01

    In accordance with recommendations made by the Finance Committee and decisions taken by Council in December 2013, no adjustments have been made to basic salaries and stipends, subsistence allowances or family benefits as at 1 January 2014. HR Department

  17. Annual adjustments to 2015 financial benefits

    CERN Multimedia

    HR Department

    2015-01-01

    In accordance with recommendations made by the Finance Committee and decisions taken by Council in December 2014, no adjustments have been made to basic salaries and stipends, subsistence allowances or family benefits as at 1 January 2015.

  18. Annual adjustments to 2016 financial benefits

    CERN Multimedia

    HR Department

    2016-01-01

    In accordance with recommendations made by the Finance Committee and decisions taken by the Council in December 2015, no adjustments have been made to basic salaries and stipends, subsistence allowances or family benefits as at 1 January 2016.  

  19. A neutron collimator with adjustable radiation field

    International Nuclear Information System (INIS)

    An adjustable neutron collimator for neutron therapy purposes is described. The collimator is designed to give a very sharp radiation field and a high freedom of choice for the radiation geometrics. (L.E.)

  20. Vietnamese Amerasians: Psychosocial Adjustment and Psychotherapy.

    Science.gov (United States)

    Bemak, Fred; Chung, Rita Chi-Ying

    1997-01-01

    Reviews the literature on Amerasians and offers suggestions for directions in psychotherapy. Provides a brief chronology of Amerasian emigration and associated psychological issues, followed by a discussion of myths and generalizations about Amerasians, research findings, and adjustment issues. (RJM)

  1. Continuity Adjustment for Control Charts for Attributes

    Institute of Scientific and Technical Information of China (English)

    L.K. Chan; T.K. Mak; B. Tao

    2003-01-01

    A unified approach is proposed for making a continuity adjustment on some control charts for attributes, e.g., np-chart and c-chart, through adding a uniform (0, 1) random observation to the conventional sample statistic (e.g., npi and ci). The adjusted sample statistic then has a continuous distribution. Consequently, given any Type I risk α (the probability that the sample statistic is on or beyond the control limits),control charts achieving the exact value of α can be readily constructed. Guidelines are given for when to use the continuity adjustment control chart, the conventional Shewhart control chart (with ±3 standard deviations control limits), and the control chart based on the exact distribution of the sample statistic before adjustment.

  2. Annual adjustments to 2013 financial benefits

    CERN Document Server

    2013-01-01

    In accordance with recommendations made by the Finance Committee and decisions taken by Council in December 2012, no adjustments have been made to basic salaries and stipends, subsistence allowances or family benefits as at 1 January 2013. HR Department

  3. Determinants of intercultural adjustment among expatriate spouses

    NARCIS (Netherlands)

    Ali, Anees; Van der Zee, K.I.; Sanders, G

    2003-01-01

    The adaptation of expatriate families to a host country seems crucial to successful fulfilment of international business assignments. The present study focused on personality, family characteristics and characteristics of expatriates' work life as determinants of the intercultural adjustment of expa

  4. Cross-cultural adjustment to the United States: the role of contextualized extraversion change.

    Science.gov (United States)

    Liu, Mengqiao; Huang, Jason L

    2015-01-01

    Personality traits can predict how well-sojourners and expatriates adjust to new cultures, but the adjustment process remains largely unexamined. Based on recent findings that reveal personality traits predict as well as respond to life events and experiences, this research focuses on within-person change in contextualized extraversion and its predictive validity for cross-cultural adjustment in international students who newly arrived in US colleges. We proposed that the initial level as well as the rate of change in school extraversion (i.e., contextualized extraversion that reflects behavioral tendency in school settings) will predict cross-cultural adjustment, withdrawal cognitions, and school satisfaction. Latent growth modeling of three-wave longitudinal surveys of 215 new international students (54% female, M age = 24 years) revealed that the initial level of school extraversion significantly predicted cross-cultural adjustment, (lower) withdrawal cognitions, and satisfaction, while the rate of change (increase) in school extraversion predicted cross-cultural adjustment and (lower) withdrawal cognitions. We further modeled global extraversion and cross-cultural motivation as antecedents and explored within-person change in school extraversion as a proximal factor that affects adjustment outcomes. The findings highlight the malleability of contextualized personality, and more importantly, the importance of understanding within-person change in contextualized personality in a cross-cultural adjustment context. The study points to more research that explicate the process of personality change in other contexts. PMID:26579033

  5. Ageing Polulations

    DEFF Research Database (Denmark)

    Christiansen, Terkel; Lauridsen, Jørgen Trankjær; Bech, Mickael

    2013-01-01

    An ageing society is characterised by an increasing median age of the population. The purpose of this chapter is to document the existing knowledge about the association between population ageing and health care expenditure, and to supplement this overview by a summary of our original research. S...

  6. Creative Aging.

    Science.gov (United States)

    Ager, Charlene Lee; And Others

    1981-01-01

    Explores some divergent attitudes toward aging, negative as well as positive. Presents a neurophysiological framework to support the belief that aging is an active and creative process. Explores physical, psychological, and sociological aspects, and identifies three factors in the creative aging process. (Author/JAC)

  7. Skin Aging

    Science.gov (United States)

    Your skin changes as you age. You might notice wrinkles, age spots and dryness. Your skin also becomes thinner and loses fat, making it ... heal, too. Sunlight is a major cause of skin aging. You can protect yourself by staying out ...

  8. Dinamika Personal Adjustment Pada Mantan PSK

    OpenAIRE

    Ginting, Reza Yoga Pratama

    2014-01-01

    The research uses qualitative approach and aims to find the personal adjustment dynamic of former sexual worker. This research uses two respondents living in Medan and Pematang Siantar. The procedure of selecting the respondent was snowball method. The data were obtain by conducting interview. Theory that has been used in this research is personal adjustment theory by Weiten & Lyoid (2006) that consist of three aspects: stress and coping stress, interpersonal realm, and developmental transiti...

  9. Evaluating Alternative Risk Adjusters for Medicare

    OpenAIRE

    Pope, Gregory C.; Adamache, Killard W.; Walsh, Edith G.; Khandker, Rezaul K.

    1998-01-01

    In this study the authors use 3 years of the Medicare Current Beneficiary Survey (MCBS) to evaluate alternative demographic, survey, and claims-based risk adjusters for Medicare capitation payment. The survey health-status models have three to four times the predictive power of the demographic models. The risk-adjustment model derived from claims diagnoses has 75-percent greater predictive power than a comprehensive survey model. No single model predicts average expenditures well for all bene...

  10. Risk adjusted equity valuation and accounting betas

    OpenAIRE

    Pope, P F; Wang, P.

    2000-01-01

    In this paper we develop a general equity valuation model where abnormal earnings, back value, the discount factor and interest rates evolve stochastically. Focusing on the dynamics of abnormal earnings, we demonstrate the back value, abnormal earnings, "other information" and two risk adjustment terms are sufficient for valuation when pricing kernel risk is attributable to a single market factor. The risk adjustment terms depend on accounting betas reflecting the covariances between abnormal...

  11. The Perception-Adjusted Luce Model

    OpenAIRE

    Echenique, Federico; Saito, Kota; Tserenjigmid, Gerelt

    2013-01-01

    We develop an axiomatic model that builds on Luce's (1959) model to incorporate a role for perception. We identify agents' "perception priorities" from their violations of Luce's axiom of independence from irrelevant alternatives. Using such perception priorities, we adjust choice probabilities to account for the effects of perception. Our axiomatization requires that the agents' adjusted random choice conforms to Luce's model. Our model can explain the attraction, compromise, and similarity ...

  12. Capital Asset Pricing Model Adjusted for Anchoring

    OpenAIRE

    Hammad, Siddiqi

    2015-01-01

    I show that adjusting CAPM for anchoring provides a unified explanation for the size, value, and momentum effects. Anchoring adjusted CAPM (ACAPM) predicts that stock splits are associated with positive abnormal returns and an increase in return volatility, whereas the reverse stock-splits are associated with negative abnormal returns and a fall in return volatility. Existing empirical evidence strongly supports these predictions. Anchoring has the effect of pushing up the equity premium, a ...

  13. Adjustment to the death of a sibling.

    OpenAIRE

    Pettle Michael, S A; Lansdown, R G

    1986-01-01

    Despite the recent increase in interest in terminally ill children and their families and the post death adjustment of parents, there has been little research examining the adjustment and self concept of surviving siblings in such families. This paper discusses the results of a preliminary descriptive study of 28 children (from 14 families) whose brother or sister had died of cancer between 18 and 30 months previously. Behaviour checklists were completed by parents and teachers and self conce...

  14. Adjustable Fiber Optic Microwave Transversal Filters

    Science.gov (United States)

    Shadaram, Mehdi; Lutes, George F.; Logan, Ronald T.; Maleki, Lutfollah

    1994-01-01

    Microwave transversal filters implemented as adjustable tapped fiber optic delay lines developed. Main advantages of these filters (in comparison with conventional microwave transversal filters) are small size, light weight, no need for matching of radio-frequency impedances, no need for shielding against electromagnetic radiation at suboptical frequencies, no need for mechanical tuning, high stability of amplitude and phase, and active control of transfer functions. Weights of taps in fiber optic delay lines adjusted.

  15. Industrial Forecasts after Export Rebates Adjustment

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ On June 19, 2007, the Circular of the Ministry of Finance and the State Administration of Taxation concerning Lowering the Export Rebate Rates for Some Commodities was published, which finally proved the early rumor of tax rebate adjustment to be true.According to the Circular, the export rebate rates for some commodities have been adjusted upon approval of the State Council and the new rates have become in force since July 1, 2007.

  16. Longitudinal Associations Between Humor Styles and Psychosocial Adjustment in Adolescence.

    Science.gov (United States)

    Fox, Claire Louise; Hunter, Simon Christopher; Jones, Siân Emily

    2016-08-01

    This study assessed the concurrent and prospective associations between psychosocial adjustment and four humor styles, two of which are adaptive (affiliative, self-enhancing) and two maladaptive (aggressive, self-defeating). Participants were 1,234 adolescents (52% female) aged 11-13 years, drawn from six secondary schools in England. Self-reports of psychosocial adjustment (loneliness, depressive symptomatology, and self-esteem) and humor styles were collected at two time points (fall and summer). In cross-lagged panel analyses, self-defeating humor was associated with an increase in both depressive symptoms and loneliness, and with a decrease in self-esteem. In addition, depressive symptoms predicted an increase in the use of self-defeating humor over time, indicating that these may represent a problematic spiral of thoughts and behaviors. Self-esteem was associated with an increase in the use of affiliative humor over the school year but not vice-versa. These results inform our understanding of the ways in which humor is associated with psychosocial adjustment in adolescence. PMID:27547255

  17. Longitudinal Associations Between Humor Styles and Psychosocial Adjustment in Adolescence

    Directory of Open Access Journals (Sweden)

    Claire Louise Fox

    2016-08-01

    Full Text Available This study assessed the concurrent and prospective associations between psychosocial adjustment and four humor styles, two of which are adaptive (affiliative, self-enhancing and two maladaptive (aggressive, self-defeating. Participants were 1,234 adolescents (52% female aged 11-13 years, drawn from six secondary schools in England. Self-reports of psychosocial adjustment (loneliness, depressive symptomatology, and self-esteem and humor styles were collected at two time points (fall and summer. In cross-lagged panel analyses, self-defeating humor was associated with an increase in both depressive symptoms and loneliness, and with a decrease in self-esteem. In addition, depressive symptoms predicted an increase in the use of self-defeating humor over time, indicating that these may represent a problematic spiral of thoughts and behaviors. Self-esteem was associated with an increase in the use of affiliative humor over the school year but not vice-versa. These results inform our understanding of the ways in which humor is associated with psychosocial adjustment in adolescence.

  18. Longitudinal Associations Between Humor Styles and Psychosocial Adjustment in Adolescence

    Science.gov (United States)

    Fox, Claire Louise; Hunter, Simon Christopher; Jones, Siân Emily

    2016-01-01

    This study assessed the concurrent and prospective associations between psychosocial adjustment and four humor styles, two of which are adaptive (affiliative, self-enhancing) and two maladaptive (aggressive, self-defeating). Participants were 1,234 adolescents (52% female) aged 11-13 years, drawn from six secondary schools in England. Self-reports of psychosocial adjustment (loneliness, depressive symptomatology, and self-esteem) and humor styles were collected at two time points (fall and summer). In cross-lagged panel analyses, self-defeating humor was associated with an increase in both depressive symptoms and loneliness, and with a decrease in self-esteem. In addition, depressive symptoms predicted an increase in the use of self-defeating humor over time, indicating that these may represent a problematic spiral of thoughts and behaviors. Self-esteem was associated with an increase in the use of affiliative humor over the school year but not vice-versa. These results inform our understanding of the ways in which humor is associated with psychosocial adjustment in adolescence. PMID:27547255

  19. Weight and age at menarche.

    OpenAIRE

    Stark, O; Peckham, C S; Moynihan, C.

    1989-01-01

    In the National Child Development Study (1958 cohort) information on their age at menarche and their weights and heights measured at 7, 11, and 16 years was available for 4427 girls. The distribution of age at menarche was not influenced by social class. Weight adjusted for height did not play an important part in the timing of sexual maturation of the girls in the study. Relative weight (weight expressed as a percentage of standard weight) at the ages of 7 and 11 years explained only 3.2%, a...

  20. Predicting Eating Disorder Continuum Groups: Hardiness and College Adjustment.

    Science.gov (United States)

    Simon-Boyd, Gail D.; Bieschke, Kathleen J.

    This study examined relationships between hardiness, college adjustment (academic adjustment, social adjustment, personal-emotional adjustment, institutional attachment) and eating disorder (ED) continuum categories in 122 female and 20 male college students. Students who exhibited a higher level of personal-emotional adjustment (PEA) to college…

  1. Skin aging:

    OpenAIRE

    Puizina-Ivić, Neira

    2008-01-01

    There are two main processes that induce skin aging: intrinsic and extrinsic. A stochastic process that implies random cell damage as a result of mutations during metabolic processes due to the production of free radicals is also implicated. Extrinsic aging is caused by environmental factors such as sun exposure, air pollution, smoking, alcohol abuse, and poor nutrition. Intrinsicaging reflects the genetic background and depends on time. Various expressions of intrinsic aging include smooth, ...

  2. Looking back: the experience of first sexual intercourse and current sexual adjustment in young heterosexual adults.

    Science.gov (United States)

    Reissing, Elke D; Andruff, Heather L; Wentland, Jocelyn J

    2012-01-01

    A young person's first consensual sexual intercourse experience is often a remarkable and memorable experience. However, little systematic information exists regarding contextual factors of first intercourse, the affective salience of the experience, possible effects on sexual attitudes and beliefs, and subsequent sexual development and adjustment. This retrospective study aimed to examine these in a sample of 475 young adults. Overall, young men and women experienced intercourse for the first time around age 17, were in a committed relationship, and reported positive affective responses. Affective reactions to the first sexual intercourse experience, sexual self-efficacy, sexual aversion, and age at first intercourse affected individuals' current sexual adjustment; however, only sexual self-efficacy mediated between first intercourse and current sexual adjustment in young men and women. Older age at first intercourse was associated with less sexual self-efficacy and lower current sexual adjustment for women. This study provides initial data to suggest that the first sexual intercourse experience significantly impacts current sexual adjustment by affecting beliefs about sexual self-efficacy. PMID:21161815

  3. 75 FR 59681 - Trade Adjustment Assistance for Farmers

    Science.gov (United States)

    2010-09-28

    ... Foreign Agricultural Service Trade Adjustment Assistance for Farmers AGENCY: Foreign Agricultural Service... Farmers Program Review Committee, comprised of representatives from USDA's Office of the Chief Economist... adjustment assistance in FY 2011. FOR FURTHER INFORMATION CONTACT: Trade Adjustment Assistance for...

  4. The variance of the adjusted Rand index.

    Science.gov (United States)

    Steinley, Douglas; Brusco, Michael J; Hubert, Lawrence

    2016-06-01

    For 30 years, the adjusted Rand index has been the preferred method for comparing 2 partitions (e.g., clusterings) of a set of observations. Although the index is widely used, little is known about its variability. Herein, the variance of the adjusted Rand index (Hubert & Arabie, 1985) is provided and its properties are explored. It is shown that a normal approximation is appropriate across a wide range of sample sizes and varying numbers of clusters. Further, it is shown that confidence intervals based on the normal distribution have desirable levels of coverage and accuracy. Finally, the first power analysis evaluating the ability to detect differences between 2, different adjusted Rand indices is provided. (PsycINFO Database Record PMID:26881693

  5. Towards Adjustable Autonomy for the Real World

    CERN Document Server

    Pynadath, D V; Tambe, M; 10.1613/jair.1037

    2011-01-01

    Adjustable autonomy refers to entities dynamically varying their own autonomy, transferring decision-making control to other entities (typically agents transferring control to human users) in key situations. Determining whether and when such transfers-of-control should occur is arguably the fundamental research problem in adjustable autonomy. Previous work has investigated various approaches to addressing this problem but has often focused on individual agent-human interactions. Unfortunately, domains requiring collaboration between teams of agents and humans reveal two key shortcomings of these previous approaches. First, these approaches use rigid one-shot transfers of control that can result in unacceptable coordination failures in multiagent settings. Second, they ignore costs (e.g., in terms of time delays or effects on actions) to an agent's team due to such transfers-of-control. To remedy these problems, this article presents a novel approach to adjustable autonomy, based on the notion of a transfer-of...

  6. Adjustments to financial and social benefits

    CERN Multimedia

    HR Department

    2010-01-01

    In accordance with recommendations made by the Finance Committee in November 2009 and decisions taken by the Council in December 2009, certain financial benefits have been adjusted with effect from 1 January 2010. An increase of 1.6% has been applied to the scale of basic salaries and to stipends paid to Fellows (Annexes R A 5 and R A 6 of the Staff Rules and Regulations, respectively). The adjusted amounts are available from the HR Department intranet site or from departmental secretariats. As a result of the evolution of the Geneva consumer price index, no adjustments have been made to the subsistence allowances of Paid Associates and Students (Annex R A 7 of the Staff Rules and Regulations). The following social benefits also remain unchanged: Family, child and infant allowances (Annex R A 3 of the Staff Rules and Regulations). Payment ceilings of education fees (Annex R A 4 of the Staff Rules and Regulations). Tel. 70674 (Classification and Remuneration Service)

  7. Psychosocial adjustment to ALS: a longitudinal study

    Directory of Open Access Journals (Sweden)

    Tamara eMatuz

    2015-09-01

    Full Text Available For the current study the Lazarian stress-coping theory and the appendant model of psychosocial adjustment to chronic illness and disabilities (Pakenham 1999 has shaped the foundation for identifying determinants of adjustment to ALS. We aimed to investigate the evolution of psychosocial adjustment to ALS and to determine its long-term predictors. A longitudinal study design with four measurement time points was therefore, used to assess patients’ quality of life, depression, and stress-coping model related aspects, such as illness characteristics, social support, cognitive appraisals and coping strategies during a period of two years. Regression analyses revealed that 55% of the variance of severity of depressive symptoms and 47% of the variance in quality of life at T2 was accounted for by all the T1 predictor variables taken together. On the level of individual contributions, protective buffering and appraisal of own coping potential accounted for a significant percentage in the variance in severity of depressive symptoms, whereas problem management coping strategies explained variance in quality of life scores. Illness characteristics at T2 did not explain any variance of both adjustment outcomes. Overall, the pattern of the longitudinal results indicated stable depressive symptoms and quality of life indices reflecting a successful adjustment to the disease across four measurement time points during a period of about two years.Empirical evidence is provided for the predictive value of social support, cognitive appraisals, and coping strategies, but not illness parameters such as severity and duration for adaptation to ALS. The current study contributes to a better conceptualization of adjustment, allowing us to provide evidence-based support beyond medical and physical intervention for people with ALS.

  8. The association between adjustment disorder diagnosed at psychiatric treatment facilities and completed suicide

    DEFF Research Database (Denmark)

    Gradus, Jaimie L; Qin, Ping; Lincoln, Alisa K;

    2010-01-01

    is associated with suicidal ideation and suicide attempt. However the association between adjustment disorder and completed suicide has yet to be examined. The current study is a population-based case control study examining this association in the population of Denmark aged 15 to 90 years. All suicides...... in Denmark from 1994 to 2006 were included, resulting in 9,612 cases. For each case, up to 30 controls were matched on gender, exact date of birth, and calendar time, yielding 199,306 controls. Adjustment disorder diagnosis was found in 7.6% of suicide cases and 0.52% of controls. Conditional logistic...... regression analyses revealed that those diagnosed with adjustment disorder had 12 times the rate of suicide as those without an adjustment disorder diagnosis, after controlling for history of depression diagnosis, marital status, income, and the matched factors....

  9. Associations between faith, distress and mental adjustment

    DEFF Research Database (Denmark)

    Johannessen-Henry, Christine Tind

    2013-01-01

    Objective. Several studies have suggested that religion and spirituality are important for overcoming psychological distress and adjusting mentally to cancer, but these studies did not differentiate between spiritual well-being and specific aspects of faith. We examined the extent to which......), specific aspects of faith ('belief in a god', 'belief in a god with whom I can talk' and 'experiences of god or a higher power'), religious community and church attendance (DUREL), distress (POMS-SF), adjustment to cancer (Mini-MAC) and sociodemographic factors. Linear regression models were used...

  10. Risk Adjusted Deposit Insurance for Japanese Banks

    OpenAIRE

    Ryuzo Sato; Rama V. Ramachandran; Bohyong Kang

    1990-01-01

    The purpose of this paper is to evaluate the Japanese deposit insurance scheme by contrasting the flat insurance rate with a market-determined risk-adjusted rate. The model used to calculate the risk-adjusted rate is that of Ronn and Verrna (1986) . It utilizes the notion of Merton(1977) that the deposit insurance can be based on a one-to-one relation between it and the put option; this permits the application of Black and Scholes(1973) model for the calculation of the insurance rate. The ris...

  11. Adjustable Speed Drives - Future Challenges and Applications

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Thoegersen, Paul

    2004-01-01

    The main trends within Adjustable Drives in industrial and appliance applications for the next decade are discussed based on the newest developments seen on the market and a few historical trends. Different drive configurations are presented and the general demands to adjustable speed drives...... are specified. Further on power architectures and motor types are discussed in a short term and long-term view. Possible drivers of the future development are identified, and the concept of an ?Electronic Motor? is discussed. A number of applications are presented where variable speed is attractive....

  12. Early Environmental Support and Elementary School Adjustment as Predictors of School Adjustment in Middle Adolescence.

    Science.gov (United States)

    Carlson, Elizabeth A.; Sroufe, L. Alan; Collins, W. Andres; Jimerson, Shane; Weinfield, Nancy; Henninghausen, Katherine; Egeland, Byron; Hyson, Daniel M.; Anderson, Fione; Meyer, Stephanie E.

    1999-01-01

    This longitudinal study examined socioemotional antecedents of adolescent school adjustment. Findings indicated that early and later parental problem-solving support accounted for 13 percent of variance in high school adjustment. Early and later parental problem-solving support, peer competence, externalizing behavior, and emotional…

  13. Family and Cultural influences on Low-income Latino Children’s Adjustment

    OpenAIRE

    Santiago, Catherine DeCarlo; Wadsworth, Martha E.

    2011-01-01

    This study examined family and cultural influences on adjustment among ninety low-income Latino middle school children (46% girls; Average age = 11.38, SD = .66) and their primary caregivers (93% Female; Average age = 36.12, SD = 6.13). All participants identified as Hispanic/Latino, with 75% of families identifying as Mexican-origin Latino, and 77% of parents and 32% of children identifying as immigrants. Hierarchical linear modeling analyses revealed that family reframing interacted with fa...

  14. Parental Depressive Symptoms, Children's Representations of Family Relationships, and Child Adjustment

    Science.gov (United States)

    Cummings, E. Mark; Schermerhorn, Alice C.; Keller, Peggy S.; Davies, Patrick T.

    2008-01-01

    This study extends the investigation of family process models of parental dysphoria and child adjustment, by examining depressive symptoms in both fathers and mothers, and by examining children's representations of family relationships as possible explanatory mechanisms. Participants were 232 children (Time 1 mean age: 5.99; 105 boys, 127 girls)…

  15. The Effects of Marital Conflict on Korean Children's Appraisal of Conflict and Psychological Adjustment

    Science.gov (United States)

    Oh, Kyung Ja; Lee, Soojin; Park, Soo Hyun

    2011-01-01

    This study examined the effects of marital conflict on Korean children's psychological adjustment and appraisal of hypothetical marital conflict situations. Children between the ages of 10 and 12 were divided into "high-conflict" (n = 58) and "low-conflict" (n = 58) groups based on their self-reported degree of perceived interparental conflict in…

  16. The Role of Early Childhood Personality in the Developmental Course of Social Adjustment

    Science.gov (United States)

    Kavcic, Tina; Podlesek, Anja; Zupancic, Maja

    2012-01-01

    This study explored children, preschool, and family characteristics that contribute to individual differences in the developmental trajectories of social competence and internalizing and externalizing behavior. Teachers reported on personality and social adjustment of 304 children at ages 3, 4, 5, and 6 years. Predictors of social adjustment…

  17. Does Adolescents' Disclosure to their Parents Matter for their Academic Adjustment?

    Science.gov (United States)

    Cheung, Cecilia S.-S.; Pomerantz, Eva M.; Dong, Wei

    2013-01-01

    The role of adolescents' disclosure to their parents in their academic adjustment was examined in a study of 825 American and Chinese adolescents (mean age = 12.73 years). Four times over the seventh and eighth grades, adolescents reported on their spontaneous disclosure of everyday activities to their parents, the quality of their relationships…

  18. The Quality of Parent/Child Relationships in Adolescence Is Associated with Poor Adult Psychosocial Adjustment

    Science.gov (United States)

    Raudino, Alessandra; Fergusson, David M.; Horwood, L. John

    2013-01-01

    This study used data gathered over the course of a New Zealand longitudinal study (N = 924) to examine the relationships between measures of parental bonding and attachment in adolescence (age 15-16) and later personal adjustment (major depression; anxiety disorder; suicidal behaviour; illicit drug abuse/dependence; crime) assessed up to the age…

  19. CRISP-Psychometric Assessment of Postdivorce Stress/Adjustment in Children.

    Science.gov (United States)

    Aronson, David M.; Baum, Steven K.

    A new psychometric instrument for measuring the impact of divorce on elementary school age children was developed: the Child's Report of the Impact of Separation by Parents (CRISP). This structured projective test was specifically designed to assess children's postdivorce stress/adjustment. An initial version of the CRISP was administered to 99…

  20. The Tenacious Goal Pursuit and Flexible Goal Adjustment Scales : A Validation Study

    NARCIS (Netherlands)

    Henselmans, Inge; Fleer, Joke; van Sonderen, Eric; Smink, Ans; Sanderman, Robbert; Ranchor, Adelita V.

    2011-01-01

    The flexible goal adjustment (FLEX) and tenacious goal pursuit (TEN) scales are used regularly in aging research. The current study examined their validity in a sample of 517 women (30-75 years) in multiple ways. Overall, the findings show that the scales do not clearly distinguish between FLEX and

  1. Negative Cognitive Errors and Positive Illusions: Moderators of Relations between Divorce Events and Children's Psychological Adjustment.

    Science.gov (United States)

    Mazur, Elizabeth; Wolchik, Sharlene

    Building on prior literature on adults' and children's appraisals of stressors, this study investigated relations among negative and positive appraisal biases, negative divorce events, and children's post-divorce adjustment. Subjects were 79 custodial nonremarried mothers and their children ages 9 to 13 who had experienced parental divorce within…

  2. Korean Children's Cultural Adjustment during Transition to the Early Years of School in Australia

    Science.gov (United States)

    Millar, Ngaire

    2011-01-01

    This study investigated Korean children's cultural adjustment during transition to South Australian junior primary school settings. Using case-study methodology to provide a sociocultural perspective, data were collected during interviews with a sample of South Korean international students aged five to eight years, their mothers and teachers. All…

  3. Developmental Trajectories of Chinese Children's Relational and Physical Aggression: Associations with Social-Psychological Adjustment Problems

    Science.gov (United States)

    Kawabata, Yoshito; Tseng, Wan-Ling; Murray-Close, Dianna; Crick, Nicki R.

    2012-01-01

    The purpose of this short-term longitudinal study was to examine Chinese children's trajectories of physical and relational aggression and their association with social-psychological adjustment problems (i.e., depressive symptoms and delinquency) and gender. Fourth and fifth grade children in Taiwan (n = 739, age 9-11) were followed across 1 year.…

  4. Grandmother-Grandchild Relationship Quality Predicts Psychological Adjustment among Youth from Divorced Families

    Science.gov (United States)

    Henderson, Craig E.; Hayslip, Bert, Jr.; Sanders, Leah M.; Louden, Linda

    2009-01-01

    This study investigates maternal grandmother-grandchild relationship quality as a predictor of psychological adjustment among youth from divorced families. Three hundred twenty-four adolescents aged between 17 and 20 report on the quality of their relationships with their maternal grandmothers and their relational competence, self-efficacy, and…

  5. Friendship Moderates Prospective Associations between Social Isolation and Adjustment Problems in Young Children

    Science.gov (United States)

    Laursen, Brett; Bukowski, William M.; Aunola, Kaisa; Nurmi, Jari-Erik

    2007-01-01

    This longitudinal study investigated prospective links between social isolation and adjustment problems among 166 (77 girls, 89 boys) Finnish children ages 7 to 9. Peer nominations for social engagement and self-reports of internalizing and externalizing problems were collected in the spring of the 1st and 2nd grade. Friendship moderated…

  6. Toddlers' Adjustment to the Stress of Immunization in Function of Mothers' General and Specific Coping Tendencies

    Science.gov (United States)

    Favez, N.; Reicherts, M.

    2008-01-01

    The aim of this research is to assess the relative influence of mothers' coping strategies in everyday life and mothers' specific coping acts on toddlers' adjustment behavior to pain and distress during a routine immunization. The population is 41 mothers with toddlers (23 girls, 18 boys; mean age, 22.7 months) undergoing a routine immunization in…

  7. Maternal Parenting and Social, School, and Psychological Adjustment of Migrant Children in Urban China

    Science.gov (United States)

    Zhao, Siman; Chen, Xinyin; Wang, Li

    2015-01-01

    This study examined the relations of maternal warmth, behavioral control, and encouragement of sociability to social, school, and psychological adjustment in migrant children in China. The participants were 284 rural-to-urban migrant children (M age = 11 years, 149 boys) in migrant children's schools and their mothers. Data on parenting were…

  8. Parent-Child Cultural Orientations and Child Adjustment in Chinese American Immigrant Families

    Science.gov (United States)

    Chen, Stephen H.; Hua, Michelle; Zhou, Qing; Tao, Annie; Lee, Erica H.; Ly, Jennifer; Main, Alexandra

    2014-01-01

    Direct and indirect/mediated relations of (a) children's and parents' cultural orientations and (b) parent-child gaps in cultural orientations to children's psychological adjustment were examined in a socioeconomically diverse sample of 258 Chinese American children (age = 6-9 years) from immigrant families. Parents reported on…

  9. Epigenetic Patterns Modulate the Connection between Developmental Dynamics of Parenting and Offspring Psychosocial Adjustment

    Science.gov (United States)

    Naumova, Oksana Yu.; Hein, Sascha; Suderman, Matthew; Barbot, Baptiste; Lee, Maria; Raefski, Adam; Dobrynin, Pavel V.; Brown, Pamela J.; Szyf, Moshe; Luthar, Suniya S.; Grigorenko, Elena L.

    2016-01-01

    This study attempted to establish and quantify the connections between parenting, offspring psychosocial adjustment, and the epigenome. The participants, 35 African American young adults (19 females and 16 males; age = 17-29.5 years), represented a subsample of a 3-wave longitudinal 15-year study on the developmental trajectories of low-income…

  10. Adoptive Gay Father Families: Parent-Child Relationships and Children's Psychological Adjustment

    Science.gov (United States)

    Golombok, Susan; Mellish, Laura; Jennings, Sarah; Casey, Polly; Tasker, Fiona; Lamb, Michael E.

    2014-01-01

    Findings are presented on a U.K. study of 41 gay father families, 40 lesbian mother families, and 49 heterosexual parent families with an adopted child aged 3-9 years. Standardized interview and observational and questionnaire measures of parental well-being, quality of parent-child relationships, child adjustment, and child sex-typed behavior…

  11. The Relations among Young Children's Peer-Reported Trustworthiness, Inhibitory Control, and Preschool Adjustment

    Science.gov (United States)

    Rotenberg, K. J.; Michalik, N.; Eisenberg, N.; Betts, L. R.

    2008-01-01

    Sixty-five (38 male and 27 female) preschool children (mean age=5 years 1 month) completed measures of peers' trustworthiness (promise keeping and secret keeping). Teachers rated the preschool children's inhibitory control, trustworthiness, and preschool adjustment. Structural Equation Modeling (SEM) yielded support for the hypothesized model. The…

  12. Relations between Parent-Child Acculturation Differences and Adjustment within Immigrant Chinese Families

    Science.gov (United States)

    Costigan, Catherine L.; Dokis, Daphn P.

    2006-01-01

    The relations between parent and child acculturation and family and child adjustment were examined among 91 immigrant Chinese families in Canada with early adolescents (average age of 12). Acculturation was assessed in public (e.g., language use) and private (e.g., values) domains separately in Chinese and Canadian cultures. With one exception,…

  13. Language Brokering Contexts and Behavioral and Emotional Adjustment among Latino Parents and Adolescents

    Science.gov (United States)

    Martinez, Charles R., Jr.; McClure, Heather H.; Eddy, J. Mark

    2009-01-01

    This study examined behavioral and emotional adjustment in family contexts in which there was high versus low demand for adolescents to serve as language brokers in a sample of 73 recently immigrated Latino families with middle-school-aged adolescents. Language brokering was conceptualized as a family process rather than merely an individual…

  14. Exploring the Psychosocial and Behavioral Adjustment Outcomes of Multi-Type Abuse among Homeless Young Adults

    Science.gov (United States)

    Ferguson, Kristin M.

    2009-01-01

    This article explores the psychosocial and behavioral adjustment outcomes associated with verbal, emotional, physical, and sexual abuse among homeless young adults as well as the associations among abuse types. Convenience sampling was used to select 28 homeless young adults (ages 18 to 24) from one drop-in center. Overall, subjects experienced…

  15. Pathways of Parenting Style on Adolescents' College Adjustment, Academic Achievement, and Alcohol Risk

    Science.gov (United States)

    Kenney, Shannon R.; Lac, Andrew; Hummer, Justin F.; Grimaldi, Elizabeth M.; LaBrie, Joseph W.

    2015-01-01

    This study examined the pathways of parenting style (permissive, authoritarian, and authoritative) to alcohol consumption and consequences through the mediators of college adjustment and academic achievement (grade point average [GPA]). Participants were 289 students from a private, mid-size, West Coast university (mean age 19.01 years, 58.8%…

  16. When Parents Divorce: Assisting Teens to Adjust through a Group Approach.

    Science.gov (United States)

    Studer, Jeannine R.; Allton, Judith A.

    1996-01-01

    Addresses factors that contribute to the adjustment difficulties of children and adolescents when their parents divorce. Gender issues, custody, age, parenting style, visitation patterns, socioeconomic considerations, the support system, family size, and the reconstituted family are all discussed. Describes a model for an effective support group…

  17. Stability in Bullying and Victimization and its Association with Social Adjustment in Childhood and Adolescence

    NARCIS (Netherlands)

    Scholte, R.H.J.; Engels, R.C.M.E.; Overbeek, G.J.; Kemp, R.A.T. de; Haselager, G.J.T.

    2007-01-01

    This study examined the concurrent and longitudinal associations between stability in bullying and victimization, and social adjustment in childhood and adolescence. Participants were 189 girls and 328 boys who were studied in primary school and in secondary school. The mean age of the participants

  18. 75 FR 4592 - January 2010 Pay Adjustments

    Science.gov (United States)

    2010-01-28

    ... INFORMATION: On December 23, 2009, the President signed Executive Order 13525 (74 FR 69231), which implemented... 2010 locality pay area definitions can be found at http://www.opm.gov/oca/10tables/locdef.asp . The Non....gov/oca/compmemo/index.asp .) The Executive order adjusted the rates of basic pay for...

  19. Output filters for AC adjustable speed drives

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Hanigovszki, Norbert; Landkildehus, Jorn, Jorn

    2007-01-01

    The standard industrial solution for adjustable speed drives (ASD) is the use of induction motors (IM) fed by voltage-source inverters (VSI). The inverter generates a pulsewidth modulated (PWM) voltage, with dv/dt values of about 6 kV/¿s or even more. In three-leg inverters for three-phase appli...

  20. Adjustable Speed Drives and Power Quality

    DEFF Research Database (Denmark)

    Davari, Pooya; Yang, Yongheng; Zare, Firuz;

    2016-01-01

    This paper provides an overview and proposes cost-effective and efficient opportunities in improving power quality in Adjustable Speed Drive (ASD) systems. In particular, an Electronic Inductor (EI) technique has been used in single drives to overcome the existing challenges in conventional...