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Sample records for affymetrix arrays expanding

  1. Genotyping and annotation of Affymetrix SNP arrays

    DEFF Research Database (Denmark)

    Lamy, Philippe; Andersen, Claus Lindbjerg; Wikman, Friedrik;

    2006-01-01

    In this paper we develop a new method for genotyping Affymetrix single nucleotide polymorphism (SNP) array. The method is based on (i) using multiple arrays at the same time to determine the genotypes and (ii) a model that relates intensities of individual SNPs to each other. The latter point...... allows us to annotate SNPs that have poor performance, either because of poor experimental conditions or because for one of the alleles the probes do not behave in a dose-response manner. Generally, our method agrees well with a method developed by Affymetrix. When both methods make a call they agree in...... 99.25% (using standard settings) of the cases, using a sample of 113 Affymetrix 10k SNP arrays. In the majority of cases where the two methods disagree, our method makes a genotype call, whereas the method by Affymetrix makes a no call, i.e. the genotype of the SNP is not determined. By visualization...

  2. A new genotype calling method for affymetrix SNP arrays.

    Science.gov (United States)

    Fu, Bilin; Xu, Jin

    2011-12-01

    Current genotype-calling methods such as Robust Linear Model with Mahalanobis Distance Classifier (RLMM) and Corrected Robust Linear Model with Maximum Likelihood Classification (CRLMM) provide accurate calling results for Affymetrix Single Nucleotide Polymorphisms (SNP) chips. However, these methods are computationally expensive as they employ preprocess procedures, including chip data normalization and other sophisticated statistical techniques. In the small sample case the accuracy rate may drop significantly. We develop a new genotype calling method for Affymetrix 100 k and 500 k SNP chips. A two-stage classification scheme is proposed to obtain a fast genotype calling algorithm. The first stage uses unsupervised classification to quickly discriminate genotypes with high accuracy for the majority of the SNPs. And the second stage employs a supervised classification method to incorporate allele frequency information either from the HapMap data or from a self-training scheme. Confidence score is provided for every genotype call. The overall performance is shown to be comparable to that of CRLMM as verified by the known gold standard HapMap data and is superior in small sample cases. The new algorithm is computationally simple and standalone in the sense that a self-training scheme can be used without employing any other training data. A package implementing the calling algorithm is freely available at http://www.sfs.ecnu.edu.cn/teachers/xuj_en.html. PMID:22084010

  3. ArrayInitiative - a tool that simplifies creating custom Affymetrix CDFs

    Directory of Open Access Journals (Sweden)

    Thompson Kevin J

    2011-05-01

    Full Text Available Abstract Background Probes on a microarray represent a frozen view of a genome and are quickly outdated when new sequencing studies extend our knowledge, resulting in significant measurement error when analyzing any microarray experiment. There are several bioinformatics approaches to improve probe assignments, but without in-house programming expertise, standardizing these custom array specifications as a usable file (e.g. as Affymetrix CDFs is difficult, owing mostly to the complexity of the specification file format. However, without correctly standardized files there is a significant barrier for testing competing analysis approaches since this file is one of the required inputs for many commonly used algorithms. The need to test combinations of probe assignments and analysis algorithms led us to develop ArrayInitiative, a tool for creating and managing custom array specifications. Results ArrayInitiative is a standalone, cross-platform, rich client desktop application for creating correctly formatted, custom versions of manufacturer-provided (default array specifications, requiring only minimal knowledge of the array specification rules and file formats. Users can import default array specifications, import probe sequences for a default array specification, design and import a custom array specification, export any array specification to multiple output formats, export the probe sequences for any array specification and browse high-level information about the microarray, such as version and number of probes. The initial release of ArrayInitiative supports the Affymetrix 3' IVT expression arrays we currently analyze, but as an open source application, we hope that others will contribute modules for other platforms. Conclusions ArrayInitiative allows researchers to create new array specifications, in a standard format, based upon their own requirements. This makes it easier to test competing design and analysis strategies that depend on probe

  4. Software comparison for evaluating genomic copy number variation for Affymetrix 6.0 SNP array platform

    Science.gov (United States)

    2011-01-01

    Background Copy number data are routinely being extracted from genome-wide association study chips using a variety of software. We empirically evaluated and compared four freely-available software packages designed for Affymetrix SNP chips to estimate copy number: Affymetrix Power Tools (APT), Aroma.Affymetrix, PennCNV and CRLMM. Our evaluation used 1,418 GENOA samples that were genotyped on the Affymetrix Genome-Wide Human SNP Array 6.0. We compared bias and variance in the locus-level copy number data, the concordance amongst regions of copy number gains/deletions and the false-positive rate amongst deleted segments. Results APT had median locus-level copy numbers closest to a value of two, whereas PennCNV and Aroma.Affymetrix had the smallest variability associated with the median copy number. Of those evaluated, only PennCNV provides copy number specific quality-control metrics and identified 136 poor CNV samples. Regions of copy number variation (CNV) were detected using the hidden Markov models provided within PennCNV and CRLMM/VanillaIce. PennCNV detected more CNVs than CRLMM/VanillaIce; the median number of CNVs detected per sample was 39 and 30, respectively. PennCNV detected most of the regions that CRLMM/VanillaIce did as well as additional CNV regions. The median concordance between PennCNV and CRLMM/VanillaIce was 47.9% for duplications and 51.5% for deletions. The estimated false-positive rate associated with deletions was similar for PennCNV and CRLMM/VanillaIce. Conclusions If the objective is to perform statistical tests on the locus-level copy number data, our empirical results suggest that PennCNV or Aroma.Affymetrix is optimal. If the objective is to perform statistical tests on the summarized segmented data then PennCNV would be preferred over CRLMM/VanillaIce. Specifically, PennCNV allows the analyst to estimate locus-level copy number, perform segmentation and evaluate CNV-specific quality-control metrics within a single software package

  5. Exon array data analysis using Affymetrix power tools and R statistical software

    Science.gov (United States)

    2011-01-01

    The use of microarray technology to measure gene expression on a genome-wide scale has been well established for more than a decade. Methods to process and analyse the vast quantity of expression data generated by a typical microarray experiment are similarly well-established. The Affymetrix Exon 1.0 ST array is a relatively new type of array, which has the capability to assess expression at the individual exon level. This allows a more comprehensive analysis of the transcriptome, and in particular enables the study of alternative splicing, a gene regulation mechanism important in both normal conditions and in diseases. Some aspects of exon array data analysis are shared with those for standard gene expression data but others present new challenges that have required development of novel tools. Here, I will introduce the exon array and present a detailed example tutorial for analysis of data generated using this platform. PMID:21498550

  6. Genome-wide analysis of antisense transcription with Affymetrix exon array

    Directory of Open Access Journals (Sweden)

    Jung Yong-chul

    2008-01-01

    Full Text Available Abstract Background A large number of natural antisense transcripts have been identified in human and mouse genomes. Study of their potential functions clearly requires cost-efficient method for expression analysis. Results Here we show that Affymetrix Exon arrays, which were designed to detect conventional transcripts in the sense orientation, can be used to monitor antisense expression across all exonic loci in mammalian genomes. Through modification of the cDNA synthesis protocol, we labeled single-strand cDNA in the reverse orientation as in the standard protocol, thus enabling the detection of antisense transcripts using the same array. Applying this technique to human Jurkat cells, we identified antisense transcription at 2,088 exonic loci of 1,516 UniGene clusters. Many of these antisense transcripts were not observed previously and some were validated by orientation-specific RT-PCR. Conclusion Our results suggest that with a modified protocol Affymetrix human, mouse and rat Exon arrays can be used as a routine method for genome-wide analysis of antisense transcription in these genomes.

  7. Expandable LED array interconnect

    Science.gov (United States)

    Yuan, Thomas Cheng-Hsin; Keller, Bernd

    2011-03-01

    A light emitting device that can function as an array element in an expandable array of such devices. The light emitting device comprises a substrate that has a top surface and a plurality of edges. Input and output terminals are mounted to the top surface of the substrate. Both terminals comprise a plurality of contact pads disposed proximate to the edges of the substrate, allowing for easy access to both terminals from multiple edges of the substrate. A lighting element is mounted to the top surface of the substrate. The lighting element is connected between the input and output terminals. The contact pads provide multiple access points to the terminals which allow for greater flexibility in design when the devices are used as array elements in an expandable array.

  8. Discovery and mapping of single feature polymorphisms in wheat using Affymetrix arrays

    Directory of Open Access Journals (Sweden)

    Hu Shengwa

    2009-05-01

    Full Text Available Abstract Background Wheat (Triticum aestivum L. is a staple food crop worldwide. The wheat genome has not yet been sequenced due to its huge genome size (~17,000 Mb and high levels of repetitive sequences; the whole genome sequence may not be expected in the near future. Available linkage maps have low marker density due to limitation in available markers; therefore new technologies that detect genome-wide polymorphisms are still needed to discover a large number of new markers for construction of high-resolution maps. A high-resolution map is a critical tool for gene isolation, molecular breeding and genomic research. Single feature polymorphism (SFP is a new microarray-based type of marker that is detected by hybridization of DNA or cRNA to oligonucleotide probes. This study was conducted to explore the feasibility of using the Affymetrix GeneChip to discover and map SFPs in the large hexaploid wheat genome. Results Six wheat varieties of diverse origins (Ning 7840, Clark, Jagger, Encruzilhada, Chinese Spring, and Opata 85 were analyzed for significant probe by variety interactions and 396 probe sets with SFPs were identified. A subset of 164 unigenes was sequenced and 54% showed polymorphism within probes. Microarray analysis of 71 recombinant inbred lines from the cross Ning 7840/Clark identified 955 SFPs and 877 of them were mapped together with 269 simple sequence repeat markers. The SFPs were randomly distributed within a chromosome but were unevenly distributed among different genomes. The B genome had the most SFPs, and the D genome had the least. Map positions of a selected set of SFPs were validated by mapping single nucleotide polymorphism using SNaPshot and comparing with expressed sequence tags mapping data. Conclusion The Affymetrix array is a cost-effective platform for SFP discovery and SFP mapping in wheat. The new high-density map constructed in this study will be a useful tool for genetic and genomic research in wheat.

  9. OpenADAM: an open source genome-wide association data management system for Affymetrix SNP arrays

    Directory of Open Access Journals (Sweden)

    Sham P C

    2008-12-01

    Full Text Available Abstract Background Large scale genome-wide association studies have become popular since the introduction of high throughput genotyping platforms. Efficient management of the vast array of data generated poses many challenges. Description We have developed an open source web-based data management system for the large amount of genotype data generated from the Affymetrix GeneChip® Mapping Array and Affymetrix Genome-Wide Human SNP Array platforms. The database supports genotype calling using DM, BRLMM, BRLMM-P or Birdseed algorithms provided by the Affymetrix Power Tools. The genotype and corresponding pedigree data are stored in a relational database for efficient downstream data manipulation and analysis, such as calculation of allele and genotype frequencies, sample identity checking, and export of genotype data in various file formats for analysis using commonly-available software. A novel method for genotyping error estimation is implemented using linkage disequilibrium information from the HapMap project. All functionalities are accessible via a web-based user interface. Conclusion OpenADAM provides an open source database system for management of Affymetrix genome-wide association SNP data.

  10. Evaluating the performance of Affymetrix SNP Array 6.0 platform with 400 Japanese individuals

    Directory of Open Access Journals (Sweden)

    Uehara Yasuka

    2008-09-01

    Full Text Available Abstract Background With improvements in genotyping technologies, genome-wide association studies with hundreds of thousands of SNPs allow the identification of candidate genetic loci for multifactorial diseases in different populations. However, genotyping errors caused by genotyping platforms or genotype calling algorithms may lead to inflation of false associations between markers and phenotypes. In addition, the number of SNPs available for genome-wide association studies in the Japanese population has been investigated using only 45 samples in the HapMap project, which could lead to an inaccurate estimation of the number of SNPs with low minor allele frequencies. We genotyped 400 Japanese samples in order to estimate the number of SNPs available for genome-wide association studies in the Japanese population and to examine the performance of the current SNP Array 6.0 platform and the genotype calling algorithm "Birdseed". Results About 20% of the 909,622 SNP markers on the array were revealed to be monomorphic in the Japanese population. Consequently, 661,599 SNPs were available for genome-wide association studies in the Japanese population, after excluding the poorly behaving SNPs. The Birdseed algorithm accurately determined the genotype calls of each sample with a high overall call rate of over 99.5% and a high concordance rate of over 99.8% using more than 48 samples after removing low-quality samples by adjusting QC criteria. Conclusion Our results confirmed that the SNP Array 6.0 platform reached the level reported by the manufacturer, and thus genome-wide association studies using the SNP Array 6.0 platform have considerable potential to identify candidate susceptibility or resistance genetic factors for multifactorial diseases in the Japanese population, as well as in other populations.

  11. Large-scale analysis of antisense transcription in wheat using the Affymetrix GeneChip Wheat Genome Array

    Directory of Open Access Journals (Sweden)

    Settles Matthew L

    2009-05-01

    Full Text Available Abstract Background Natural antisense transcripts (NATs are transcripts of the opposite DNA strand to the sense-strand either at the same locus (cis-encoded or a different locus (trans-encoded. They can affect gene expression at multiple stages including transcription, RNA processing and transport, and translation. NATs give rise to sense-antisense transcript pairs and the number of these identified has escalated greatly with the availability of DNA sequencing resources and public databases. Traditionally, NATs were identified by the alignment of full-length cDNAs or expressed sequence tags to genome sequences, but an alternative method for large-scale detection of sense-antisense transcript pairs involves the use of microarrays. In this study we developed a novel protocol to assay sense- and antisense-strand transcription on the 55 K Affymetrix GeneChip Wheat Genome Array, which is a 3' in vitro transcription (3'IVT expression array. We selected five different tissue types for assay to enable maximum discovery, and used the 'Chinese Spring' wheat genotype because most of the wheat GeneChip probe sequences were based on its genomic sequence. This study is the first report of using a 3'IVT expression array to discover the expression of natural sense-antisense transcript pairs, and may be considered as proof-of-concept. Results By using alternative target preparation schemes, both the sense- and antisense-strand derived transcripts were labeled and hybridized to the Wheat GeneChip. Quality assurance verified that successful hybridization did occur in the antisense-strand assay. A stringent threshold for positive hybridization was applied, which resulted in the identification of 110 sense-antisense transcript pairs, as well as 80 potentially antisense-specific transcripts. Strand-specific RT-PCR validated the microarray observations, and showed that antisense transcription is likely to be tissue specific. For the annotated sense

  12. Genome-wide loss of heterozygosity and copy number alteration in esophageal squamous cell carcinoma using the Affymetrix GeneChip Mapping 10 K array

    Directory of Open Access Journals (Sweden)

    Goldstein Alisa M

    2006-11-01

    Full Text Available Abstract Background Esophageal squamous cell carcinoma (ESCC is a common malignancy worldwide. Comprehensive genomic characterization of ESCC will further our understanding of the carcinogenesis process in this disease. Results Genome-wide detection of chromosomal changes was performed using the Affymetrix GeneChip 10 K single nucleotide polymorphism (SNP array, including loss of heterozygosity (LOH and copy number alterations (CNA, for 26 pairs of matched germ-line and micro-dissected tumor DNA samples. LOH regions were identified by two methods – using Affymetrix's genotype call software and using Affymetrix's copy number alteration tool (CNAT software – and both approaches yielded similar results. Non-random LOH regions were found on 10 chromosomal arms (in decreasing order of frequency: 17p, 9p, 9q, 13q, 17q, 4q, 4p, 3p, 15q, and 5q, including 20 novel LOH regions (10 kb to 4.26 Mb. Fifteen CNA-loss regions (200 kb to 4.3 Mb and 36 CNA-gain regions (200 kb to 9.3 Mb were also identified. Conclusion These studies demonstrate that the Affymetrix 10 K SNP chip is a valid platform to integrate analyses of LOH and CNA. The comprehensive knowledge gained from this analysis will enable improved strategies to prevent, diagnose, and treat ESCC.

  13. Combining Affymetrix microarray results

    Directory of Open Access Journals (Sweden)

    Doerge RW

    2005-03-01

    Full Text Available Abstract Background As the use of microarray technology becomes more prevalent it is not unusual to find several laboratories employing the same microarray technology to identify genes related to the same condition in the same species. Although the experimental specifics are similar, typically a different list of statistically significant genes result from each data analysis. Results We propose a statistically-based meta-analytic approach to microarray analysis for the purpose of systematically combining results from the different laboratories. This approach provides a more precise view of genes that are significantly related to the condition of interest while simultaneously allowing for differences between laboratories. Of particular interest is the widely used Affymetrix oligonucleotide array, the results of which are naturally suited to a meta-analysis. A simulation model based on the Affymetrix platform is developed to examine the adaptive nature of the meta-analytic approach and to illustrate the usefulness of such an approach in combining microarray results across laboratories. The approach is then applied to real data involving a mouse model for multiple sclerosis. Conclusion The quantitative estimates from the meta-analysis model tend to be closer to the "true" degree of differential expression than any single lab. Meta-analytic methods can systematically combine Affymetrix results from different laboratories to gain a clearer understanding of genes' relationships to specific conditions of interest.

  14. Dissecting an alternative splicing analysis workflow for GeneChip® Exon 1.0 ST Affymetrix arrays

    Directory of Open Access Journals (Sweden)

    Calogero Raffaele A

    2008-11-01

    Full Text Available Abstract Background A new microarray platform (GeneChip® Exon 1.0 ST has recently been developed by Affymetrix http://www.affymetrix.com. This microarray platform changes the conventional view of transcript analysis since it allows the evaluation of the expression level of a transcript by querying each exon component. The Exon 1.0 ST platform does however raise some issues regarding the approaches to be used in identifying genome-wide alternative splicing events (ASEs. In this study an exon-level data analysis workflow is dissected in order to detect limit and strength of each step, thus modifying the overall workflow and thereby optimizing the detection of ASEs. Results This study was carried out using a semi-synthetic exon-skipping benchmark experiment embedding a total of 268 exon skipping events. Our results point out that summarization methods (RMA, PLIER do not affect the efficacy of statistical tools in detecting ASEs. However, data pre-filtering is mandatory if the detected number of false ASEs are to be reduced. MiDAS and Rank Product methods efficiently detect true ASEs but they suffer from the lack of multiple test error correction. The intersection of MiDAS and Rank Product results efficiently moderates the detection of false ASEs. Conclusion To optimize the detection of ASEs we propose the following workflow: i data pre-filtering, ii statistical selection of ASEs using both MiDAS and Rank Product, iii intersection of results derived from the two statistical analyses in order to moderate family-wise errors (FWER.

  15. Comparative Transcriptomic Profiling of Vitis vinifera Under High Light Using a Custom-Made Array and the Affymetrix GeneChip

    Institute of Scientific and Technical Information of China (English)

    Luisa C. Carvalho; Belmiro J. Vilela; Phil M. Mullineaux; Sara Am(a)ncio

    2011-01-01

    Understanding abiotic stress responses is one of the most important issues in plant research nowadays.Abiotic stress,including excess light,can promote the onset of oxidative stress through the accumulation of reactive oxygen species.Oxidative stress also arises when in vitro propagated plants are exposed to high light upon transfer to ex vitro.To determine whether the underlying pathways activated at the transfer of in vitro grapevine to ex vitro conditions reflect the processes occurring upon light stress,we used Vitis vinifera Affymetrix GeneChip (VvGA) and a custom array of genes responsive to light stress (LSCA) detected by real-time reverse transcriptase PCR (qRT-PCR).When gene-expression profiles were compared,‘protein metabolism and modification',‘signaling',and ‘anti-oxidative' genes were more represented in LSCA,while,in VvGA,‘cell wall metabolism' and ‘secondary metabolism' were the categories in which gene expression varied more significantly.The above functional categories confirm previous studies involving other types of abiotic stresses,enhancing the common attributes of abiotic stress defense pathways.The LSCA analysis of our experimental system detected strong response of heat shock genes,particularly the protein rescuing mechanism involving the cooperation of two ATP-dependent chaperone systems,Hsp100 and Hsp70,which showed an unusually late response during the recovery period,of extreme relevance to remove non-functional,potentially harmful polypeptides arising from misfolding,denaturation,or aggregation brought about by stress.The success of LSCA also proves the feasibility of a custommade qRT-PCR approach,particularly for species for which no GeneChip is available and for researchers dealing with a specific and focused problem.

  16. Genome-Wide analysis of allelic imbalance in laser microdissected prostate cancer tissue using the Affymetrix 50K Mapping array identifies genomic patterns associated with metastasis and differentiation

    DEFF Research Database (Denmark)

    Tørring, Niels; Borre, Michael; Sørensen, Karina;

    2007-01-01

    to be developed for patient stratification based on risk of progression. We analysed laser-microdissected prostate tumour tissue from 43 patients with histologically verified PCa, using the new high-resolution Affymetrix Mapping 50K single-nucleotide polymorphism array. The results showed six major...... loss. However, tumour progression towards a metastatic stage, as well as poor differentiation, was identified by specific patterns of copy number gains of genomic regions located at chromosomes 8q, 1q, 3q and 7q. Androgen ablation therapy was further characterised by copy gain at chromosomes 2p and 10q...

  17. Early Observations with the Expanded Owens Valley Solar Array

    Science.gov (United States)

    Gary, Dale E.

    2016-05-01

    The Expanded Owens Valley Solar Array (EOVSA) is a newly expanded and upgraded, solar-dedicated radio array consisting of 13 antennas of 2.1 m diameter equipped with receivers designed to cover the 1-18 GHz frequency range. Two large (27-m diameter) dishes are being outfitted with He-cooled receivers for use in calibration of the small dishes. During 2015, the array obtained observations from dozens of flares in total power mode on 8 antennas. Since February 2016, it has begun taking solar data on all 13 small antennas with full interferometric correlations, as well as calibration observations with the first of the two large antennas equipped with its He-cooled receiver. The second He-cooled receiver is nearly complete, and will be available around the time of the meeting. We briefly review the commissioning activities leading up to full operations, including polarization and gain measurements and calibration methods, and resulting measures of array performance. We then present some early imaging observations with the array, emphasizing the remarkable temporal and spectral resolution of the instrument, together with joint RHESSI hard X-ray and SDO EUV observations.

  18. Computational method for reducing variance with Affymetrix microarrays

    Directory of Open Access Journals (Sweden)

    Brooks Andrew I

    2002-08-01

    Full Text Available Abstract Background Affymetrix microarrays are used by many laboratories to generate gene expression profiles. Generally, only large differences (> 1.7-fold between conditions have been reported. Computational methods to reduce inter-array variability might be of value when attempting to detect smaller differences. We examined whether inter-array variability could be reduced by using data based on the Affymetrix algorithm for pairwise comparisons between arrays (ratio method rather than data based on the algorithm for analysis of individual arrays (signal method. Six HG-U95A arrays that probed mRNA from young (21–31 yr old human muscle were compared with six arrays that probed mRNA from older (62–77 yr old muscle. Results Differences in mean expression levels of young and old subjects were small, rarely > 1.5-fold. The mean within-group coefficient of variation for 4629 mRNAs expressed in muscle was 20% according to the ratio method and 25% according to the signal method. The ratio method yielded more differences according to t-tests (124 vs. 98 differences at P Conclusion The ratio method reduces inter-array variance and thereby enhances statistical power.

  19. Modelling background intensity in Affymetrix Genechips

    CERN Document Server

    Kroll, K M; Carlon, E

    2008-01-01

    DNA microarrays are devices that are able, in principle, to detect and quantify the presence of specific nucleic acid sequences in complex biological mixtures. The measurement consists in detecting fluorescence signals from several spots on the microarray surface onto which different probe sequences are grafted. One of the problems of the data analysis is that the signal contains a noisy background component due to non-specific binding. This paper presents a physical model for background estimation in Affymetrix Genechips. It combines two different approaches. The first is based on the sequence composition, specifically its sequence dependent hybridization affinity. The second is based on the strong correlation of intensities from locations which are the physical neighbors of a specific spot on the chip. Both effects are incorporated in a background functional which contains 24 free parameters, fixed by minimization on a training data set. In all data analyzed the sequence specific parameters, obtained by min...

  20. The Expanded Very Large Array -- a New Telescope for New Science

    CERN Document Server

    Perley, R A; Butler, B J; Wrobel, J M

    2011-01-01

    Since its commissioning in 1980, the Very Large Array (VLA) has consistently demonstrated its scientific productivity. However, its fundamental capabilities have changed little since 1980, particularly in the key areas of sensitivity, frequency coverage, and velocity resolution. These limitations have been addressed by a major upgrade of the array, which began in 2001 and will be completed at the end of 2012. When completed, the Expanded VLA -- the EVLA -- will provide complete frequency coverage from 1 to 50 GHz, a continuum sensitivity of typically 1 microJy/beam (in 9 hours with full bandwidth), and a modern correlator with vastly greater capabilities and flexibility than the VLA's. In this paper we describe the goals of the EVLA project, its current status, and the anticipated expansion of capabilities over the next few years. User access to the array through the OSRO and RSRO programs is described. The following papers in this special issue, derived from observations in its early science period, demonstr...

  1. EXPANDED VERY LARGE ARRAY NOVA PROJECT OBSERVATIONS OF THE CLASSICAL NOVA V1723 AQUILAE

    International Nuclear Information System (INIS)

    We present radio light curves and spectra of the classical nova V1723 Aql obtained with the Expanded Very Large Array (EVLA). This is the first paper to showcase results from the EVLA Nova Project, which comprises a team of observers and theorists utilizing the greatly enhanced sensitivity and frequency coverage of EVLA radio observations, along with observations at other wavelengths, to reach a deeper understanding of the energetics, morphology, and temporal characteristics of nova explosions. Our observations of V1723 Aql span 1-37 GHz in frequency, and we report on data from 14 to 175 days following the time of the nova explosion. The broad frequency coverage and frequent monitoring show that the radio behavior of V1723 Aql does not follow the classic Hubble-flow model of homologous spherically expanding thermal ejecta. The spectra are always at least partially optically thin, and the flux rises on faster timescales than can be reproduced with linear expansion. Therefore, any description of the underlying physical processes must go beyond this simple picture. The unusual spectral properties and light curve evolution might be explained by multiple emitting regions or shocked material. Indeed, X-ray observations from Swift reveal that shocks are likely present.

  2. An Imaging Spectral Line Survey of IRC+10216 using the Expanded Very Large Array (EVLA)

    Science.gov (United States)

    Claussen, Mark J.; EVLA Scientific Commissioning Team

    2011-01-01

    The Expanded Very Large Array (EVLA) is currently undergoing scientific commissioning, with full scientific operations expected in 2013. During the commissioning, we have performed a rather coarse ( 25 km/s) and shallow imaging spectral survey of the circumstellar environment of the well-known and nearby carbon-rich asymptotic giant branch (AGB) star IRC+10°216 (CW Leo) in the frequency range 18 - 26.5 GHz, using the capability of the WIDAR correlator to simultaneously observe 2 GHz of bandwidth. In addition we have used the additional capability of WIDAR to observe widely spaced sub-bands to observe eight pairs of targeted lines with much better spectral resolution (1.0 - 2.0 km/s) in the 18 - 26.5 GHz receiver band (selected from the coarse survey) and the 26.5 - 40 GHz receiver band (selected from the single-dish survey of Kawaguchi et al. (1995, PASJ, 47, 853). In the coarse survey, we detected twenty-one transitions of eleven molecules including eight transitions of HC7N, ranging from 18.049 GHz to 25.946 GHz, the J = 1 - 0 maser transition of SiS at 18.156 GHz, and three transitions of HC5N. We will present further results of the survey and images of the emission from the targeted lines. The National Radio Astronomy is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc.

  3. Simple volume expanding fabrication method for focal length controlled micro-lens array

    Science.gov (United States)

    Kim, Junoh; Lee, Muyung; Kim, Cheol Joong; Lee, Jin Su; Won, Yong Hyub

    2015-03-01

    This study describes easy fabrication method for micro-lens array which has desired focal length in such a way that without the use of reflow technique. The process includes conventional lithographic process only which can be compatible with general semiconductor process. As constituent material, Negative photo-resist SU-8 with its developer PGMEA is used. Two main phenomena during lithography process are adjusted to expand the volume of the PR. During UV exposure, hardening proceeds from the top of the PR. Just after first exposure, using this property, very thin membrane on the top of the surface of the PR can be formed by short time exposure. In the development process, unexposed area of the PR is removed by chemical reaction with developer which causes the volume expansion if the unexposed area is covered with thin cured film. This method is to form the lens as the molecules in the volume are not easily escaped from the covered region. The thickness of the thin film depends on the exposure dose of 2mJ cm-2 μm-1 which determines the degree of expansion. The symmetrical volume expansion creates the membrane of lens shape and the focal length is directly related with second exposure dose. An extended research of affecting the change of the focal length of lens using volume expansion method by changing any other elements is discussed. This process can achieve a focal length selective for the applications of micro-optics.

  4. EXPANDED VERY LARGE ARRAY OBSERVATIONS OF THE RADIO EVOLUTION OF SN 2011dh

    International Nuclear Information System (INIS)

    We report on Expanded Very Large Array observations of the Type IIb supernova 2011dh, performed over the first 100 days of its evolution and spanning 1-40 GHz in frequency. The radio emission is well described by the self-similar propagation of a spherical shockwave, generated as the supernova ejecta interact with the local circumstellar environment. Modeling this emission with a standard synchrotron self-absorption (SSA) model gives an average expansion velocity of v ≈ 0.1c, supporting the classification of the progenitor as a compact star (R* ≈ 1011 cm). We find that the circumstellar density is consistent with a ρ∝r–2 profile. We determine that the progenitor shed mass at a constant rate of ≈3 × 10–5 M☉ yr–1, assuming a wind velocity of 1000 km s–1 (values appropriate for a Wolf-Rayet star), or ≈7 × 10–7 M☉ yr–1 assuming 20 km s–1 (appropriate for a yellow supergiant [YSG] star). Both values of the mass-loss rate assume a converted fraction of kinetic to magnetic energy density of εB = 0.1. Although optical imaging shows the presence of a YSG, the rapid optical evolution and fast expansion argue that the progenitor is a more compact star—perhaps a companion to the YSG. Furthermore, the excellent agreement of the radio properties of SN 2011dh with the SSA model implies that any YSG companion is likely in a wide, non-interacting orbit.

  5. AMiBA: Cluster Sunyaev-Zel'dovich Effect Observations with the Expanded 13-Element Array

    OpenAIRE

    Lin, Kai-Yang; Nishioka, Hiroaki; Wang, Fu-Cheng; Huang, Chih-Wei Locutus; Liao, Yu-Wei; Wu, Jiun-Huei Proty; Koch, Patrick M.; Umetsu, Keiichi; Chen, Ming-Tang; Chan, Shun-Hsiang; Chang, Shu-Hao; Chang, Wen-Hsuan Lucky; Cheng, Tai-An; Duy, Hoang Ngoc; Fu, Szu-Yuan

    2016-01-01

    The Yuan-Tseh Lee Array for Microwave Background Anisotropy (AMiBA) is a co-planar interferometer array operating at a wavelength of 3mm to measure the Sunyaev-Zeldovich effect (SZE) of galaxy clusters. In the first phase of operation -- with a compact 7-element array with 0.6m antennas (AMiBA-7) -- we observed six clusters at angular scales from 5\\arcmin to 23\\arcmin. Here, we describe the expansion of AMiBA to a 13-element array with 1.2m antennas (AMiBA-13), its subsequent commissioning, a...

  6. AMiBA: Cluster Sunyaev-Zel'dovich Effect Observations with the Expanded 13-Element Array

    CERN Document Server

    Lin, Kai-Yang; Wang, Fu-Cheng; Huang, Chih-Wei Locutus; Liao, Yu-Wei; Wu, Jiun-Huei Proty; Koch, Patrick M; Umetsu, Keiichi; Chen, Ming-Tang; Chan, Shun-Hsiang; Chang, Shu-Hao; Chang, Wen-Hsuan Lucky; Cheng, Tai-An; Duy, Hoang Ngoc; Fu, Szu-Yuan; Han, Chih-Chiang; Ho, Solomon; Ho, Ming-Feng; Ho, Paul T P; Huang, Yau-De; Jiang, Homin; Kubo, Derek Y; Li, Chao-Te; Lin, Yu-Chiung; Liu, Guo-Chin; Martin-Cocher, Pierre; Molnar, Sandor M; Nunez, Emmanuel; Oshiro, Peter; Pai, Shang-Ping; Raffin, Philippe; Ridenour, Anthony; Shih, Chia-You; Stoebner, Sara; Teo, Giap-Siong; Yeh, Jia-Long Johnny; Williams, Joshua; Birkinshaw, Mark

    2016-01-01

    The Yuan-Tseh Lee Array for Microwave Background Anisotropy (AMiBA) is a co-planar interferometer array operating at a wavelength of 3mm to measure the Sunyaev-Zeldovich effect (SZE) of galaxy clusters. In the first phase of operation -- with a compact 7-element array with 0.6m antennas (AMiBA-7) -- we observed six clusters at angular scales from 5\\arcmin to 23\\arcmin. Here, we describe the expansion of AMiBA to a 13-element array with 1.2m antennas (AMiBA-13), its subsequent commissioning, and our cluster SZE observing program. The most important changes compared to AMiBA-7 are (1) array re-configuration with baselines ranging from 1.4m to 4.8m covering angular scales from 2\\arcmin to 11.5\\arcmin, (2) thirteen new lightweight carbon-fiber-reinforced plastic (CFRP) 1.2m reflectors, and (3) additional correlators and six new receivers. From the AMiBA-13 SZE observing program, we present here maps of a subset of twelve clusters. In highlights, we combine AMiBA-7 and AMiBA-13 observations of Abell 1689 and perfo...

  7. Expanding Coherent Array Processing to Larger Apertures Using Empirical Matched Field Processing

    Energy Technology Data Exchange (ETDEWEB)

    Ringdal, F; Harris, D B; Kvaerna, T; Gibbons, S J

    2009-07-23

    We have adapted matched field processing, a method developed in underwater acoustics to detect and locate targets, to classify transient seismic signals arising from mining explosions. Matched field processing, as we apply it, is an empirical technique, using observations of historic events to calibrate the amplitude and phase structure of wavefields incident upon an array aperture for particular repeating sources. The objective of this project is to determine how broadly applicable the method is and to understand the phenomena that control its performance. We obtained our original results in distinguishing events from ten mines in the Khibiny and Olenegorsk mining districts of the Kola Peninsula, for which we had exceptional ground truth information. In a cross-validation test, some 98.2% of 549 explosions were correctly classified by originating mine using just the Pn observations (2.5-12.5 Hz) on the ARCES array at ranges from 350-410 kilometers. These results were achieved despite the fact that the mines are as closely spaced as 3 kilometers. Such classification performance is significantly better than predicted by the Rayleigh limit. Scattering phenomena account for the increased resolution, as we make clear in an analysis of the information carrying capacity of Pn under two alternative propagation scenarios: free-space propagation and propagation with realistic (actually measured) spatial covariance structure. The increase in information capacity over a wide band is captured by the matched field calibrations and used to separate explosions from very closely-spaced sources. In part, the improvement occurs because the calibrations enable coherent processing at frequencies above those normally considered coherent. We are investigating whether similar results can be expected in different regions, with apertures of increasing scale and for diffuse seismicity. We verified similar performance with the closely-spaced Zapolyarni mines, though discovered that it may be

  8. ‘maskBAD’ – a package to detect and remove Affymetrix probes with binding affinity differences

    Directory of Open Access Journals (Sweden)

    Dannemann Michael

    2012-04-01

    Full Text Available Abstract Background Hybridization differences caused by target sequence differences can be a confounding factor in analyzing gene expression on microarrays, lead to false positives and reduce power to detect real expression differences. We prepared an R Bioconductor compatible package to detect, characterize and remove such probes in Affymetrix 3’IVT and exon-based arrays on the basis of correlation of signal intensities from probes within probe sets. Results Using completely mouse genomes we determined type 1 (false negatives and type 2 (false positives errors with high accuracy and we show that our method routinely outperforms previous methods. When detecting 76.2% of known SNP/indels in mouse expression data, we obtain at most 5.5% false positives. At the same level of false positives, best previous method detected 72.6%. We also show that probes with differing binding affinity both hinder differential expression detection and introduce artifacts in cancer-healthy tissue comparison. Conclusions Detection and removal of such probes should be a routine step in Affymetrix data preprocessing. We prepared a user friendly R package, compatible with Bioconductor, that allows the filtering and improving of data from Affymetrix microarrays experiments.

  9. DMET-Analyzer: automatic analysis of Affymetrix DMET Data

    Directory of Open Access Journals (Sweden)

    Guzzi Pietro

    2012-10-01

    Full Text Available Abstract Background Clinical Bioinformatics is currently growing and is based on the integration of clinical and omics data aiming at the development of personalized medicine. Thus the introduction of novel technologies able to investigate the relationship among clinical states and biological machineries may help the development of this field. For instance the Affymetrix DMET platform (drug metabolism enzymes and transporters is able to study the relationship among the variation of the genome of patients and drug metabolism, detecting SNPs (Single Nucleotide Polymorphism on genes related to drug metabolism. This may allow for instance to find genetic variants in patients which present different drug responses, in pharmacogenomics and clinical studies. Despite this, there is currently a lack in the development of open-source algorithms and tools for the analysis of DMET data. Existing software tools for DMET data generally allow only the preprocessing of binary data (e.g. the DMET-Console provided by Affymetrix and simple data analysis operations, but do not allow to test the association of the presence of SNPs with the response to drugs. Results We developed DMET-Analyzer a tool for the automatic association analysis among the variation of the patient genomes and the clinical conditions of patients, i.e. the different response to drugs. The proposed system allows: (i to automatize the workflow of analysis of DMET-SNP data avoiding the use of multiple tools; (ii the automatic annotation of DMET-SNP data and the search in existing databases of SNPs (e.g. dbSNP, (iii the association of SNP with pathway through the search in PharmaGKB, a major knowledge base for pharmacogenomic studies. DMET-Analyzer has a simple graphical user interface that allows users (doctors/biologists to upload and analyse DMET files produced by Affymetrix DMET-Console in an interactive way. The effectiveness and easy use of DMET Analyzer is demonstrated through different

  10. An expandable crosstalk reduction method for inline fiber Fabry–Pérot sensor array based on fiber Bragg gratings

    Science.gov (United States)

    Jiang, Peng; Ma, Lina; Hu, Zhengliang; Hu, Yongming

    2016-07-01

    The inline time division multiplexing (TDM) fiber Fabry–Pérot (FFP) sensor array based on fiber Bragg gratings (FBGs) is attractive for many applications. But the intrinsic multi-reflection (MR) induced crosstalk limits applications especially those needing high resolution. In this paper we proposed an expandable method for MR-induced crosstalk reduction. The method is based on complexing-exponent synthesis using the phase-generated carrier (PGC) scheme and the special common character of the impulse responses. The method could promote demodulation stability simultaneously with the reduction of MR-induced crosstalk. A polarization-maintaining 3-TDM experimental system with an FBG reflectivity of about 5 % was set up to validate the method. The experimental results showed that crosstalk reduction of 13 dB and 15 dB was achieved for sensor 2 and sensor 3 respectively when a signal was applied to the first sensor and crosstalk reduction of 8 dB was achieved for sensor 3 when a signal was applied to sensor 2. The demodulation stability of the applied signal was promoted as well. The standard deviations of the amplitude distributions of the demodulated signals were reduced from 0.0046 to 0.0021 for sensor 2 and from 0.0114 to 0.0044 for sensor 3. Because of the convenience of the linear operation of the complexing-exponent and according to the common character of the impulse response we found, the method can be effectively extended to the array with more TDM channels if the impulse response of the inline FFP sensor array with more TDM channels is derived. It offers potential to develop a low-crosstalk inline FFP sensor array using the PGC interrogation technique with relatively high reflectivity FBGs which can guarantee enough light power received by the photo-detector.

  11. THE FAINTEST RADIO SOURCE YET: EXPANDED VERY LARGE ARRAY OBSERVATIONS OF THE GRAVITATIONAL LENS SDSS J1004+4112

    International Nuclear Information System (INIS)

    We present new radio observations of the large-separation gravitationally lensed quasar SDSS J1004+4112, taken in a total of 6 hr of observations with the Expanded Very Large Array. The maps reach a thermal noise level of approximately 4 μJy. We detect four of the five lensed images at the 15-35 μJy level, representing a source of intrinsic flux density, after allowing for lensing magnification, of about 1 μJy, intrinsically probably the faintest radio source yet detected. This reinforces the utility of gravitational lensing in potentially allowing us to study nJy-level sources before the advent of the Square Kilometre Array. In an optical observation taken three months after the radio observation, image C is the brightest image, whereas the radio map shows flux density ratios consistent with previous optical observations. Future observations separated by a time delay will give the intrinsic flux ratios of the images in this source.

  12. AN EXPANDED VERY LARGE ARRAY AND CARMA STUDY OF DUSTY DISKS AND TORII WITH LARGE GRAINS IN DYING STARS

    International Nuclear Information System (INIS)

    We report the results of a pilot multiwavelength survey in the radio continuum (X, Ka, and Q bands, i.e., from 3.6 cm to 7 mm) carried out with the Expanded Very Large Array (EVLA) in order to confirm the presence of very large dust grains in dusty disks and torii around the central stars in a small sample of post-asymptotic giant branch (pAGB) objects, as inferred from millimeter (mm) and submillimeter (submm) observations. Supporting mm-wave observations were also obtained with the Combined Array for Research in Millimeter-wave Astronomy toward three of our sources. Our EVLA survey has resulted in a robust detection of our most prominent submm emission source, the pre-planetary nebula (PPN) IRAS 22036+5306, in all three bands, and the disk-prominent pAGB object, RV Tau, in one band. The observed fluxes are consistent with optically thin free-free emission, and since they are insignificant compared to their submm/mm fluxes, we conclude that the latter must come from substantial masses of cool, large (mm-sized) grains. We find that the power-law emissivity in the cm-to-submm range for the large grains in IRAS22036 is νβ, with β = 1-1.3. Furthermore, the value of β in the 3-0.85 mm range for the three disk-prominent pAGB sources (β ≤ 0.4) is significantly lower than that of IRAS22036, suggesting that the grains in pAGB objects with circumbinary disks are likely larger than those in the dusty waists of pre-planetary nebulae.

  13. EXPANDED VERY LARGE ARRAY DETECTION OF 44.1 GHz CLASS I METHANOL MASERS IN SAGITTARIUS A

    International Nuclear Information System (INIS)

    We report on the detection of 44 GHz Class I methanol (CH3OH) maser emission in the Sagittarius A (Sgr A) complex with the Expanded Very Large Array (EVLA). These EVLA observations show that the Sgr A complex harbors at least four different tracers of shocked regions in the radio regime. The 44 GHz masers correlate with the positions and velocities of previously detected 36 GHz CH3OH masers, but less with 1720 MHz OH masers. Our detections agree with theoretical predictions that the densities and temperatures conducive for 1720 MHz OH masers may also produce 36 and 44 GHz CH3OH maser emission. However, many 44 GHz masers do not overlap with 36 GHz methanol masers, suggesting that 44 GHz masers also arise in regions too hot and too dense for 36 GHz masers to form. This agrees with the non-detection of 1720 MHz OH masers in the same area, which are thought to be excited under even cooler and less dense conditions. We speculate that the geometry of the 36 GHz masers outlines the current location of a shock front.

  14. Ranking differentially expressed genes from Affymetrix gene expression data: methods with reproducibility, sensitivity, and specificity

    Directory of Open Access Journals (Sweden)

    Shimizu Kentaro

    2009-04-01

    Full Text Available Abstract Background To identify differentially expressed genes (DEGs from microarray data, users of the Affymetrix GeneChip system need to select both a preprocessing algorithm to obtain expression-level measurements and a way of ranking genes to obtain the most plausible candidates. We recently recommended suitable combinations of a preprocessing algorithm and gene ranking method that can be used to identify DEGs with a higher level of sensitivity and specificity. However, in addition to these recommendations, researchers also want to know which combinations enhance reproducibility. Results We compared eight conventional methods for ranking genes: weighted average difference (WAD, average difference (AD, fold change (FC, rank products (RP, moderated t statistic (modT, significance analysis of microarrays (samT, shrinkage t statistic (shrinkT, and intensity-based moderated t statistic (ibmT with six preprocessing algorithms (PLIER, VSN, FARMS, multi-mgMOS (mmgMOS, MBEI, and GCRMA. A total of 36 real experimental datasets was evaluated on the basis of the area under the receiver operating characteristic curve (AUC as a measure for both sensitivity and specificity. We found that the RP method performed well for VSN-, FARMS-, MBEI-, and GCRMA-preprocessed data, and the WAD method performed well for mmgMOS-preprocessed data. Our analysis of the MicroArray Quality Control (MAQC project's datasets showed that the FC-based gene ranking methods (WAD, AD, FC, and RP had a higher level of reproducibility: The percentages of overlapping genes (POGs across different sites for the FC-based methods were higher overall than those for the t-statistic-based methods (modT, samT, shrinkT, and ibmT. In particular, POG values for WAD were the highest overall among the FC-based methods irrespective of the choice of preprocessing algorithm. Conclusion Our results demonstrate that to increase sensitivity, specificity, and reproducibility in microarray analyses, we need

  15. Comparison of seven methods for producing Affymetrix expression scores based on False Discovery Rates in disease profiling data

    Directory of Open Access Journals (Sweden)

    Gruber Stephen B

    2005-02-01

    Full Text Available Abstract Background A critical step in processing oligonucleotide microarray data is combining the information in multiple probes to produce a single number that best captures the expression level of a RNA transcript. Several systematic studies comparing multiple methods for array processing have used tightly controlled calibration data sets as the basis for comparison. Here we compare performances for seven processing methods using two data sets originally collected for disease profiling studies. An emphasis is placed on understanding sensitivity for detecting differentially expressed genes in terms of two key statistical determinants: test statistic variability for non-differentially expressed genes, and test statistic size for truly differentially expressed genes. Results In the two data sets considered here, up to seven-fold variation across the processing methods was found in the number of genes detected at a given false discovery rate (FDR. The best performing methods called up to 90% of the same genes differentially expressed, had less variable test statistics under randomization, and had a greater number of large test statistics in the experimental data. Poor performance of one method was directly tied to a tendency to produce highly variable test statistic values under randomization. Based on an overall measure of performance, two of the seven methods (Dchip and a trimmed mean approach are superior in the two data sets considered here. Two other methods (MAS5 and GCRMA-EB are inferior, while results for the other three methods are mixed. Conclusions Choice of processing method has a major impact on differential expression analysis of microarray data. Previously reported performance analyses using tightly controlled calibration data sets are not highly consistent with results reported here using data from human tissue samples. Performance of array processing methods in disease profiling and other realistic biological studies should be

  16. Coverage and characteristics of the Affymetrix GeneChip Human Mapping 100K SNP set.

    Directory of Open Access Journals (Sweden)

    2006-05-01

    Full Text Available Improvements in technology have made it possible to conduct genome-wide association mapping at costs within reach of academic investigators, and experiments are currently being conducted with a variety of high-throughput platforms. To provide an appropriate context for interpreting results of such studies, we summarize here results of an investigation of one of the first of these technologies to be publicly available, the Affymetrix GeneChip Human Mapping 100K set of single nucleotide polymorphisms (SNPs. In a systematic analysis of the pattern and distribution of SNPs in the Mapping 100K set, we find that SNPs in this set are undersampled from coding regions (both nonsynonymous and synonymous and oversampled from regions outside genes, relative to SNPs in the overall HapMap database. In addition, we utilize a novel multilocus linkage disequilibrium (LD coefficient based on information content (analogous to the information content scores commonly used for linkage mapping that is equivalent to the familiar measure r2 in the special case of two loci. Using this approach, we are able to summarize for any subset of markers, such as the Affymetrix Mapping 100K set, the information available for association mapping in that subset, relative to the information available in the full set of markers included in the HapMap, and highlight circumstances in which this multilocus measure of LD provides substantial additional insight about the haplotype structure in a region over pairwise measures of LD.

  17. μ-CS: An extension of the TM4 platform to manage Affymetrix binary data

    Directory of Open Access Journals (Sweden)

    Cannataro Mario

    2010-06-01

    Full Text Available Abstract Background A main goal in understanding cell mechanisms is to explain the relationship among genes and related molecular processes through the combined use of technological platforms and bioinformatics analysis. High throughput platforms, such as microarrays, enable the investigation of the whole genome in a single experiment. There exist different kind of microarray platforms, that produce different types of binary data (images and raw data. Moreover, also considering a single vendor, different chips are available. The analysis of microarray data requires an initial preprocessing phase (i.e. normalization and summarization of raw data that makes them suitable for use on existing platforms, such as the TIGR M4 Suite. Nevertheless, the annotations of data with additional information such as gene function, is needed to perform more powerful analysis. Raw data preprocessing and annotation is often performed in a manual and error prone way. Moreover, many available preprocessing tools do not support annotation. Thus novel, platform independent, and possibly open source tools enabling the semi-automatic preprocessing and annotation of microarray data are needed. Results The paper presents μ-CS (Microarray Cel file Summarizer, a cross-platform tool for the automatic normalization, summarization and annotation of Affymetrix binary data. μ-CS is based on a client-server architecture. The μ-CS client is provided both as a plug-in of the TIGR M4 platform and as a Java standalone tool and enables users to read, preprocess and analyse binary microarray data, avoiding the manual invocation of external tools (e.g. the Affymetrix Power Tools, the manual loading of preprocessing libraries, and the management of intermediate files. The μ-CS server automatically updates the references to the summarization and annotation libraries that are provided to the μ-CS client before the preprocessing. The μ-CS server is based on the web services technology

  18. The Affymetrix DMET Plus Platform Reveals Unique Distribution of ADME-Related Variants in Ethnic Arabs

    Directory of Open Access Journals (Sweden)

    Salma M. Wakil

    2015-01-01

    Full Text Available Background. The Affymetrix Drug Metabolizing Enzymes and Transporters (DMET Plus Premier Pack has been designed to genotype 1936 gene variants thought to be essential for screening patients in personalized drug therapy. These variants include the cytochrome P450s (CYP450s, the key metabolizing enzymes, many other enzymes involved in phase I and phase II pharmacokinetic reactions, and signaling mediators associated with variability in clinical response to numerous drugs not only among individuals, but also between ethnic populations. Materials and Methods. We genotyped 600 Saudi individuals for 1936 variants on the DMET platform to evaluate their clinical potential in personalized medicine in ethnic Arabs. Results. Approximately 49% each of the 437 CYP450 variants, 56% of the 581 transporters, 56% of 419 transferases, 48% of the 104 dehydrogenases, and 58% of the remaining 390 variants were detected. Several variants, such as rs3740071, rs6193, rs258751, rs6199, rs11568421, and rs8187797, exhibited significantly either higher or lower minor allele frequencies (MAFs than those in other ethnic groups. Discussion. The present study revealed some unique distribution trends for several variants in Arabs, which displayed partly inverse allelic prevalence compared to other ethnic populations. The results point therefore to the need to verify and ascertain the prevalence of a variant as a prerequisite for engaging it in clinical routine screening in personalized medicine in any given population.

  19. A Bayesian calibration model for combining different pre-processing methods in Affymetrix chips

    Directory of Open Access Journals (Sweden)

    Richardson Sylvia

    2008-12-01

    Full Text Available Abstract Background In gene expression studies a key role is played by the so called "pre-processing", a series of steps designed to extract the signal and account for the sources of variability due to the technology used rather than to biological differences between the RNA samples. At the moment there is no commonly agreed gold standard pre-processing method and each researcher has the responsibility to choose one method, incurring the risk of false positive and false negative features arising from the particular method chosen. Results We propose a Bayesian calibration model that makes use of the information provided by several pre-processing methods and we show that this model gives a better assessment of the 'true' unknown differential expression between two conditions. We demonstrate how to estimate the posterior distribution of the differential expression values of interest from the combined information. Conclusion On simulated data and on the spike-in Latin Square dataset from Affymetrix the Bayesian calibration model proves to have more power than each pre-processing method. Its biological interest is demonstrated through an experimental example on publicly available data.

  20. High Fidelity Copy Number Analysis of Formalin-Fixed and Paraffin-Embedded Tissues Using Affymetrix Cytoscan HD Chip

    OpenAIRE

    Yu, Yan P.; Amantha Michalopoulos; Ying Ding; George Tseng; Jian-Hua Luo

    2014-01-01

    Detection of human genome copy number variation (CNV) is one of the most important analyses in diagnosing human malignancies. Genome CNV detection in formalin-fixed and paraffin-embedded (FFPE) tissues remains challenging due to suboptimal DNA quality and failure to use appropriate baseline controls for such tissues. Here, we report a modified method in analyzing CNV in FFPE tissues using microarray with Affymetrix Cytoscan HD chips. Gel purification was applied to select DNA with good qualit...

  1. Expanding the HAWC Observatory

    Energy Technology Data Exchange (ETDEWEB)

    Mori, Johanna [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-08-17

    The High Altitude Water Cherenkov Gamma-Ray Observatory is expanding its current array of 300 water tanks to include 350 outrigger tanks to increase sensitivity to gamma rays above 10 TeV. This involves creating and testing hardware with which to build the new tanks, including photomultiplier tubes, high voltage supply units, and flash analog to digital converters. My responsibilities this summer included preparing, testing and calibrating that equipment.

  2. Expanding subjectivities

    DEFF Research Database (Denmark)

    Lundgaard Andersen, Linda; Soldz, Stephen

    2012-01-01

    A major theme in recent psychoanalytic thinking concerns the use of therapist subjectivity, especially “countertransference,” in understanding patients. This thinking converges with and expands developments in qualitative research regarding the use of researcher subjectivity as a tool to understa...

  3. Expanding Universe

    Science.gov (United States)

    Schrödinger, E.

    2011-02-01

    Preface; Part I. The de Sitter Universe: 1. Synthetic construction; 2. The reduced model: geodesics; 3. The elliptic interpretation; 4. The static frame; 5. The determination of parallaxes; 6. The Lemaître-Robertson frame; Part II. The Theory of Geodesics: 7. On null geodesics; i. Determination of the parameter for null lines in special cases; ii. Frequency shift; 8. Free particles and light rays in general expanding spaces, flat or hyperspherical; i. Flat spaces; ii. Spherical spaces; iii. The red shift for spherical spaces; Part III. Waves in General Riemannian Space-Time: 9. The nature of our approximation; 10. The Hamilton-Jacobi theory in a gravitational field; 11. Procuring approximate solutions of the Hamilton-Jacobi equation from wave theory; Part IV. Waves in an Expanding Universe: 12. General considerations; 13. Proper vibrations and wave parcels; Bibliography.

  4. High-quality genotyping data from formalin-fixed, paraffin-embedded tissue on the drug metabolizing enzymes and transporters plus array

    NARCIS (Netherlands)

    Vos, H.I.; Straaten, T. van der; Coenen, M.J.H.; Flucke, U.E.; Loo, D.M.W.M. te; Guchelaar, H.J.

    2015-01-01

    The Affymetrix Drug Metabolizing Enzymes and Transporters (DMET) Plus array covers 1936 markers in 231 genes involved in drug metabolism and transport. Blood- and saliva-derived DNA works well on the DMET array, but the utility of DNA from FFPE tissue has not been reported for this array. As the abi

  5. Partition expanders

    Czech Academy of Sciences Publication Activity Database

    Gavinsky, Dmitry; Pudlák, Pavel

    Dagstuhl: Schloss Dagstuhl, Leibniz-Zentrum für Informatik, 2014 - (Mayr, E.; Portier, N.), s. 325-336. (Leibniz International Proceedings in Informatics. 25). ISBN 978-3-939897-65-1. ISSN 1868-8969. [International Symposium on Theoretical Aspects of Computer Science (STACS 2014), /31./. Lyon (FR), 05.03.2014-08.03.2014] R&D Projects: GA ČR GBP202/12/G061 Institutional support: RVO:67985840 Keywords : partitions * expanders * random graphs Subject RIV: BA - General Mathematics http://drops.dagstuhl.de/opus/volltexte/2014/4468/

  6. Development and application of a 6.5 million feature Affymetrix Genechip® for massively parallel discovery of single position polymorphisms in lettuce (Lactuca spp.

    Directory of Open Access Journals (Sweden)

    Stoffel Kevin

    2012-05-01

    Full Text Available Abstract Background High-resolution genetic maps are needed in many crops to help characterize the genetic diversity that determines agriculturally important traits. Hybridization to microarrays to detect single feature polymorphisms is a powerful technique for marker discovery and genotyping because of its highly parallel nature. However, microarrays designed for gene expression analysis rarely provide sufficient gene coverage for optimal detection of nucleotide polymorphisms, which limits utility in species with low rates of polymorphism such as lettuce (Lactuca sativa. Results We developed a 6.5 million feature Affymetrix GeneChip® for efficient polymorphism discovery and genotyping, as well as for analysis of gene expression in lettuce. Probes on the microarray were designed from 26,809 unigenes from cultivated lettuce and an additional 8,819 unigenes from four related species (L. serriola, L. saligna, L. virosa and L. perennis. Where possible, probes were tiled with a 2 bp stagger, alternating on each DNA strand; providing an average of 187 probes covering approximately 600 bp for each of over 35,000 unigenes; resulting in up to 13 fold redundancy in coverage per nucleotide. We developed protocols for hybridization of genomic DNA to the GeneChip® and refined custom algorithms that utilized coverage from multiple, high quality probes to detect single position polymorphisms in 2 bp sliding windows across each unigene. This allowed us to detect greater than 18,000 polymorphisms between the parental lines of our core mapping population, as well as numerous polymorphisms between cultivated lettuce and wild species in the lettuce genepool. Using marker data from our diversity panel comprised of 52 accessions from the five species listed above, we were able to separate accessions by species using both phylogenetic and principal component analyses. Additionally, we estimated the diversity between different types of cultivated lettuce and

  7. Development of a high density 600K SNP genotyping array for chicken

    OpenAIRE

    Kranis, Andreas; Gheyas, Almas A; Boschiero, Clarissa; Turner, Frances; Yu, Le; Smith, Sarah; Talbot, Richard; Pirani, Ali; Brew, Fiona; Kaiser, Pete; Hocking, Paul M.; Fife, Mark; Salmon, Nigel; Fulton, Janet; Strom, Tim M

    2013-01-01

    Background High density (HD) SNP genotyping arrays are an important tool for genetic analyses of animals and plants. Although the chicken is one of the most important farm animals, no HD array is yet available for high resolution genetic analysis of this species. Results We report here the development of a 600 K Affymetrix® Axiom® HD genotyping array designed using SNPs segregating in a wide variety of chicken populations. In order to generate a large catalogue of segregating SNPs, ...

  8. Distinct molecular phenotype of inflammatory breast cancer compared to non-inflammatory breast cancer using Affymetrix-based genome-wide gene-expression analysis

    OpenAIRE

    Van Laere, S; Van der Auwera, I; Van den Eynden, G; Van Hummelen, P; van Dam, P; Van Marck, E; Vermeulen, P B; Dirix, L

    2007-01-01

    The present study aims at a platform-independent confirmation of previously obtained cDNA microarray results on inflammatory breast cancer (IBC) using Affymetrix chips. Gene-expression data of 19 IBC and 40 non-IBC specimens were subjected to clustering and principal component analysis. The performance of a previously identified IBC signature was tested using clustering and gene set enrichment analysis. The presence of different cell-of-origin subtypes in IBC was investigated and confirmed us...

  9. An overview of custom array sequencing.

    Science.gov (United States)

    Kothiyal, Prachi; Cox, Stephanie; Ebert, Jonathan; Aronow, Bruce J; Greinwald, John H; Rehm, Heidi L

    2009-04-01

    This unit provides an overview of oligo hybridization-based resequencing and a wide range of considerations for implementing the technology and analyzing the resulting data. The specific technology discussed is the Affymetrix GeneChip CustomSeq Resequencing Array platform. Concepts related to array design, experimental protocols, and base-calling using existing algorithms are presented. Details that should be evaluated during development of sequence tiling, target amplification, and PCR protocols are addressed. An overview of the Affymetrix GeneChip Sequence Analysis Software (GSEQ) is provided, along with factors that influence base-calling coverage and accuracy. Also outlined are performance measures that can be used to characterize base-calling with resequencing arrays, as well as factors known to affect their performance. Limitations associated with detection of insertions and deletions (indels) are discussed, with empirical data from our experiments used to outline possible approaches to indel detection. Critical topics in the design, implementation, and analysis of targeted sequencing arrays not previously discussed in detail are highlighted. PMID:19360699

  10. Detection of pathogenic copy number variants in children with idiopathic intellectual disability using 500 K SNP array genomic hybridization

    OpenAIRE

    Li H Irene; Lemyre Emmanuelle; Langlois Sylvie; Gibson William T; Flibotte Stephane; Delaney Allen D; Chai David; Chan Susanna; Boerkoel Cornelius; Birch Patricia; Baross Agnes; Armstrong Linlea; Arbour Laura; Adam Shelin; Friedman JM

    2009-01-01

    Abstract Background Array genomic hybridization is being used clinically to detect pathogenic copy number variants in children with intellectual disability and other birth defects. However, there is no agreement regarding the kind of array, the distribution of probes across the genome, or the resolution that is most appropriate for clinical use. Results We performed 500 K Affymetrix GeneChip® array genomic hybridization in 100 idiopathic intellectual disability trios, each comprised of a chil...

  11. ExonMiner: Web service for analysis of GeneChip Exon array data

    OpenAIRE

    Imoto Seiya; Saito Ayumu; Nagasaki Masao; Yoshida Ryo; Numata Kazuyuki; Miyano Satoru

    2008-01-01

    Abstract Background Some splicing isoform-specific transcriptional regulations are related to disease. Therefore, detection of disease specific splice variations is the first step for finding disease specific transcriptional regulations. Affymetrix Human Exon 1.0 ST Array can measure exon-level expression profiles that are suitable to find differentially expressed exons in genome-wide scale. However, exon array produces massive datasets that are more than we can handle and analyze on personal...

  12. Using expression arrays for copy number detection: an example from E. coli

    Directory of Open Access Journals (Sweden)

    Stitzer Michael E

    2007-06-01

    Full Text Available Abstract Background The sequencing of many genomes and tiling arrays consisting of millions of DNA segments spanning entire genomes have made high-resolution copy number analysis possible. Microarray-based comparative genomic hybridization (array CGH has enabled the high-resolution detection of DNA copy number aberrations. While many of the methods and algorithms developed for the analysis microarrays have focused on expression analysis, the same technology can be used to detect genetic alterations, using for example standard commercial Affymetrix arrays. Due to the nature of the resultant data, standard techniques for processing GeneChip expression experiments are inapplicable. Results We have developed a robust and flexible methodology for high-resolution analysis of DNA copy number of whole genomes, using Affymetrix high-density expression oligonucleotide microarrays. Copy number is obtained from fluorescence signals after processing with novel normalization, spatial artifact correction, data transformation and deletion/duplication detection. We applied our approach to identify deleted and amplified regions in E. coli mutants obtained after prolonged starvation. Conclusion The availability of Affymetrix expression chips for a wide variety of organisms makes the proposed array CGH methodology useful more generally.

  13. Development of a high density 600K SNP genotyping array for chicken

    OpenAIRE

    Kranis, Andreas; Gheyas, Almas A; Boschiero, Clarissa; Turner, Frances; Yu, Le; Smith, Sarah; Talbot, Richard; Pirani, Ali; Brew, Fiona; Kaiser, Pete; Hocking, Paul M.; Fife, Mark; Salmon, Nigel; Fulton, Janet; Strom, Tim M

    2013-01-01

    BACKGROUND: High density (HD) SNP genotyping arrays are an important tool for genetic analyses of animals and plants. Although the chicken is one of the most important farm animals, no HD array is yet available for high resolution genetic analysis of this species. RESULTS: We report here the development of a 600 K Affymetrix(R) Axiom(R) HD genotyping array designed using SNPs segregating in a wide variety of chicken populations. In order to generate a large catalogue of segregating SNPs, we r...

  14. On Expanded Cyclic Codes

    CERN Document Server

    Wu, Yingquan

    2008-01-01

    The paper has a threefold purpose. The first purpose is to present an explicit description of expanded cyclic codes defined in $\\GF(q^m)$. The proposed explicit construction of expanded generator matrix and expanded parity check matrix maintains the symbol-wise algebraic structure and thus keeps many important original characteristics. The second purpose of this paper is to identify a class of constant-weight cyclic codes. Specifically, we show that a well-known class of $q$-ary BCH codes excluding the all-zero codeword are constant-weight cyclic codes. Moreover, we show this class of codes achieve the Plotkin bound. The last purpose of the paper is to characterize expanded cyclic codes utilizing the proposed expanded generator matrix and parity check matrix. We analyze the properties of component codewords of a codeword and particularly establish the precise conditions under which a codeword can be represented by a subbasis. With the new insights, we present an improved lower bound on the minimum distance of...

  15. Silicon microfabricated beam expander

    Energy Technology Data Exchange (ETDEWEB)

    Othman, A., E-mail: aliman@ppinang.uitm.edu.my; Ibrahim, M. N.; Hamzah, I. H.; Sulaiman, A. A. [Faculty of Electrical Engineering, Universiti Teknologi MARA Malaysia, 40450, Shah Alam, Selangor (Malaysia); Ain, M. F. [School of Electrical and Electronic Engineering, Engineering Campus, Universiti Sains Malaysia, Seri Ampangan, 14300,Nibong Tebal, Pulau Pinang (Malaysia)

    2015-03-30

    The feasibility design and development methods of silicon microfabricated beam expander are described. Silicon bulk micromachining fabrication technology is used in producing features of the structure. A high-precision complex 3-D shape of the expander can be formed by exploiting the predictable anisotropic wet etching characteristics of single-crystal silicon in aqueous Potassium-Hydroxide (KOH) solution. The beam-expander consist of two elements, a micromachined silicon reflector chamber and micro-Fresnel zone plate. The micro-Fresnel element is patterned using lithographic methods. The reflector chamber element has a depth of 40 µm, a diameter of 15 mm and gold-coated surfaces. The impact on the depth, diameter of the chamber and absorption for improved performance are discussed.

  16. A Brassica exon array for whole-transcript gene expression profiling.

    Directory of Open Access Journals (Sweden)

    Christopher G Love

    Full Text Available Affymetrix GeneChip® arrays are used widely to study transcriptional changes in response to developmental and environmental stimuli. GeneChip® arrays comprise multiple 25-mer oligonucleotide probes per gene and retain certain advantages over direct sequencing. For plants, there are several public GeneChip® arrays whose probes are localised primarily in 3' exons. Plant whole-transcript (WT GeneChip® arrays are not yet publicly available, although WT resolution is needed to study complex crop genomes such as Brassica, which are typified by segmental duplications containing paralogous genes and/or allopolyploidy. Available sequence data were sampled from the Brassica A and C genomes, and 142,997 gene models identified. The assembled gene models were then used to establish a comprehensive public WT exon array for transcriptomics studies. The Affymetrix GeneChip® Brassica Exon 1.0 ST Array is a 5 µM feature size array, containing 2.4 million 25-base oligonucleotide probes representing 135,201 gene models, with 15 probes per gene distributed among exons. Discrimination of the gene models was based on an E-value cut-off of 1E(-5, with ≤98% sequence identity. The 135 k Brassica Exon Array was validated by quantifying transcriptome differences between leaf and root tissue from a reference Brassica rapa line (R-o-18, and categorisation by Gene Ontologies (GO based on gene orthology with Arabidopsis thaliana. Technical validation involved comparison of the exon array with a 60-mer array platform using the same starting RNA samples. The 135 k Brassica Exon Array is a robust platform. All data relating to the array design and probe identities are available in the public domain and are curated within the BrassEnsembl genome viewer at http://www.brassica.info/BrassEnsembl/index.html.

  17. Array2BIO: from microarray expression data to functional annotation of co-regulated genes

    Directory of Open Access Journals (Sweden)

    Rasley Amy

    2006-06-01

    Full Text Available Abstract Background There are several isolated tools for partial analysis of microarray expression data. To provide an integrative, easy-to-use and automated toolkit for the analysis of Affymetrix microarray expression data we have developed Array2BIO, an application that couples several analytical methods into a single web based utility. Results Array2BIO converts raw intensities into probe expression values, automatically maps those to genes, and subsequently identifies groups of co-expressed genes using two complementary approaches: (1 comparative analysis of signal versus control and (2 clustering analysis of gene expression across different conditions. The identified genes are assigned to functional categories based on Gene Ontology classification and KEGG protein interaction pathways. Array2BIO reliably handles low-expressor genes and provides a set of statistical methods for quantifying expression levels, including Benjamini-Hochberg and Bonferroni multiple testing corrections. An automated interface with the ECR Browser provides evolutionary conservation analysis for the identified gene loci while the interconnection with Crème allows prediction of gene regulatory elements that underlie observed expression patterns. Conclusion We have developed Array2BIO – a web based tool for rapid comprehensive analysis of Affymetrix microarray expression data, which also allows users to link expression data to Dcode.org comparative genomics tools and integrates a system for translating co-expression data into mechanisms of gene co-regulation. Array2BIO is publicly available at http://array2bio.dcode.org.

  18. Loss of heterozygosity analyzed by single nucleotide polymorphisrn array in cancer

    Institute of Scientific and Technical Information of China (English)

    HaiTao Zheng; ZhiHai Peng; Sheng Li; Lin He

    2005-01-01

    Neoplastic progression is generally characterized by the accumulation of multiple genetic alterations including loss of tumor suppression gene function.Loss of heterozygosity (LOH) has been used to identify genomic regions that harbor tumor suppressor genes and to characterize different tumor types, pathological stages and progression. LOH pattern has been detected by allelotyping using restriction fragment length polymorphism, and later by simple sequence length polymorphisms (SSLPs or microsatellite) for 10 years.This paper reviews the detection of LOH by recently developed single nucleotide polymorphism (SNP) arrays (all analyzed by Affymetrix array); furthermore, its advantage and disadvantage were analyzed in several kinds of cancer.

  19. Growth factors in multiple myeloma: a comprehensive analysis of their expression in tumor cells and bone marrow environment using Affymetrix microarrays

    Directory of Open Access Journals (Sweden)

    Meißner Tobias

    2010-05-01

    Full Text Available Abstract Background Multiple myeloma (MM is characterized by a strong dependence of the tumor cells on their microenvironment, which produces growth factors supporting survival and proliferation of myeloma cells (MMC. In the past few years, many myeloma growth factors (MGF have been described in the literature. However, their relative importance and the nature of the cells producing MGF remain unidentified for many of them. Methods We have analysed the expression of 51 MGF and 36 MGF receptors (MGFR using Affymetrix microarrays throughout normal plasma cell differentiation, in MMC and in cells from the bone marrow (BM microenvironment (CD14, CD3, polymorphonuclear neutrophils, stromal cells and osteoclasts. Results 4/51 MGF and 9/36 MGF-receptors genes were significantly overexpressed in plasmablasts (PPC and BM plasma cell (BMPC compared to B cells whereas 11 MGF and 11 MGFR genes were overexpressed in BMPC compared to PPC. 3 MGF genes (AREG, NRG3, Wnt5A and none of the receptors were significantly overexpressed in MMC versus BMPC. Furthermore, 3/51 MGF genes were overexpressed in MMC compared to the the BM microenvironment whereas 22/51 MGF genes were overexpressed in one environment subpopulation compared to MMC. Conclusions Two major messages arise from this analysis 1 The majority of MGF genes is expressed by the bone marrow environment. 2 Several MGF and their receptors are overexpressed throughout normal plasma cell differentiation. This study provides an extensive and comparative analysis of MGF expression in plasma cell differentiation and in MM and gives new insights in the understanding of intercellular communication signals in MM.

  20. Growth factors in multiple myeloma: a comprehensive analysis of their expression in tumor cells and bone marrow environment using Affymetrix microarrays

    International Nuclear Information System (INIS)

    Multiple myeloma (MM) is characterized by a strong dependence of the tumor cells on their microenvironment, which produces growth factors supporting survival and proliferation of myeloma cells (MMC). In the past few years, many myeloma growth factors (MGF) have been described in the literature. However, their relative importance and the nature of the cells producing MGF remain unidentified for many of them. We have analysed the expression of 51 MGF and 36 MGF receptors (MGFR) using Affymetrix microarrays throughout normal plasma cell differentiation, in MMC and in cells from the bone marrow (BM) microenvironment (CD14, CD3, polymorphonuclear neutrophils, stromal cells and osteoclasts). 4/51 MGF and 9/36 MGF-receptors genes were significantly overexpressed in plasmablasts (PPC) and BM plasma cell (BMPC) compared to B cells whereas 11 MGF and 11 MGFR genes were overexpressed in BMPC compared to PPC. 3 MGF genes (AREG, NRG3, Wnt5A) and none of the receptors were significantly overexpressed in MMC versus BMPC. Furthermore, 3/51 MGF genes were overexpressed in MMC compared to the the BM microenvironment whereas 22/51 MGF genes were overexpressed in one environment subpopulation compared to MMC. Two major messages arise from this analysis 1) The majority of MGF genes is expressed by the bone marrow environment. 2) Several MGF and their receptors are overexpressed throughout normal plasma cell differentiation. This study provides an extensive and comparative analysis of MGF expression in plasma cell differentiation and in MM and gives new insights in the understanding of intercellular communication signals in MM

  1. Grazing incidence beam expander

    Energy Technology Data Exchange (ETDEWEB)

    Akkapeddi, P.R.; Glenn, P.; Fuschetto, A.; Appert, Q.; Viswanathan, V.K.

    1985-01-01

    A Grazing Incidence Beam Expander (GIBE) telescope is being designed and fabricated to be used as an equivalent end mirror in a long laser resonator cavity. The design requirements for this GIBE flow down from a generic Free Electron Laser (FEL) resonator. The nature of the FEL gain volume (a thin, pencil-like, on-axis region) dictates that the output beam be very small. Such a thin beam with the high power levels characteristic of FELs would have to travel perhaps hundreds of meters or more before expanding enough to allow reflection from cooled mirrors. A GIBE, on the other hand, would allow placing these optics closer to the gain region and thus reduces the cavity lengths substantially. Results are presented relating to optical and mechanical design, alignment sensitivity analysis, radius of curvature analysis, laser cavity stability analysis of a linear stable concentric laser cavity with a GIBE. Fabrication details of the GIBE are also given.

  2. Trinity (for Expanded Orchestra)

    OpenAIRE

    Winokur, Robert Michael

    2011-01-01

    Trinity is a large-scale piece of program music for a symphony orchestra expanded to include two electric guitars (doubling on acoustic guitar), piano (doubling on Fender Rhodes Electric Piano), electric bass guitar and drumset. The main philosophical impetus for this piece is the programmatic depiction (in the manner of a tone poem) of a concept which is based on and combines archetypal characters drawn primarily from literary sources. This dissertation is titled Trinity and uses the thesi...

  3. MoEDAL expands

    CERN Multimedia

    Anaïs Schaeffer

    2011-01-01

    The MoEDAL collaboration deployed a test array of 18 plastic Nuclear Track Etch Detector (NTD) stacks – covering an area of 1 m2 – in the MoEDAL/VELO cavern at Point 8 of the LHC ring in November 2009. This small array was supplemented by a further 110 stacks this past January. The MoEDAL test array, which now covers an area of 8 m2, will reveal its secrets early in 2013. The full MoEDAL detector will be installed in the next long shutdown of the LHC in 2013.   View of the MoEDAL detectors installed at Point 8 of the LHC ring in January 2011. MoEDAL (Monopole and Exotics Detector At the LHC), the seventh LHC experiment, was approved by the CERN Research Board at the end of 2009. Its goal is to search for very specific exotics such as highly ionising massive stable (or pseudo-stable) particles with conventional electrical charge and magnetic monopoles. “The main LHC experiments are designed to detect conventionally charged particles, with conventional ionisation patte...

  4. Expanding Your Horizon 2015

    CERN Multimedia

    Kaltenhauser, Kristin

    2015-01-01

    Expanding your horizons is a bi-annual “Science Day” for girls aged 11 to 14, held at the University of Geneva on 14 November. The girls had the opportunity to take part in hands-on workshops held by local professional women in the field of science, mathematics, engineering and technology. For the fourth time, CERN was part of this event, offering three workshops as well as a booth at the Discovery Fair, including Higgnite, an interactive visualization of the Higgs Field.

  5. The expanding universe

    CERN Document Server

    Lew, Kristi

    2011-01-01

    People have always been fascinated with the stars above and the universe that contains them. Over the years, astronomers have developed numerous theories to explain how the universe began, how it works, and what its ultimate fate will be. But all of the scientists' questions are far from answered. The Expanding Universe goes beyond the creation of the universe to explain how scientists think the universe works, grows, and changes, including what great thinkers Isaac Newton and Albert Einstein had to say about its fate. Readers will also learn about how researchers are slowly shedding light on

  6. Circular Loudspeaker Array with Controllable Directivity

    DEFF Research Database (Denmark)

    Møller, Martin; Olsen, Martin; Agerkvist, Finn T.;

    2010-01-01

    Specific directivity patterns for circular arrays of loudspeakers can be achieved by utilizing the concept of phase-modes, which expands the directivity pattern into a series of circular harmonics. This paper investigates the applicability of this concept applied on a loudspeaker array on a...

  7. Construction of a versatile SNP array for pyramiding useful genes of rice.

    Science.gov (United States)

    Kurokawa, Yusuke; Noda, Tomonori; Yamagata, Yoshiyuki; Angeles-Shim, Rosalyn; Sunohara, Hidehiko; Uehara, Kanako; Furuta, Tomoyuki; Nagai, Keisuke; Jena, Kshirod Kumar; Yasui, Hideshi; Yoshimura, Atsushi; Ashikari, Motoyuki; Doi, Kazuyuki

    2016-01-01

    DNA marker-assisted selection (MAS) has become an indispensable component of breeding. Single nucleotide polymorphisms (SNP) are the most frequent polymorphism in the rice genome. However, SNP markers are not readily employed in MAS because of limitations in genotyping platforms. Here the authors report a Golden Gate SNP array that targets specific genes controlling yield-related traits and biotic stress resistance in rice. As a first step, the SNP genotypes were surveyed in 31 parental varieties using the Affymetrix Rice 44K SNP microarray. The haplotype information for 16 target genes was then converted to the Golden Gate platform with 143-plex markers. Haplotypes for the 14 useful allele are unique and can discriminate among all other varieties. The genotyping consistency between the Affymetrix microarray and the Golden Gate array was 92.8%, and the accuracy of the Golden Gate array was confirmed in 3 F2 segregating populations. The concept of the haplotype-based selection by using the constructed SNP array was proofed. PMID:26566831

  8. Transcription profiling by array of Arabidopsis thaliana wild type (Col-0) and flowering time mutants to investigate synchronized induction of flowering

    OpenAIRE

    Valentim, F.L.; Mourik, van, J.A.; Posé, D.; Kim, M.C.; M. Schmid; van der Ham; Busscher, M.; Sanchez-Perez, G.F.; Molenaar, J.; Immink, G.H.; Dijk, van, G.

    2013-01-01

    Synchronized induction of flowering in Arabidopsis thaliana wild type (Col-0) and flowering time mutants (soc1, agl24, fd) by shifting from short day (8 hr light, 16 hr dark; 23C; 65% rel humidity) to long day (16 hr light, 8 hr dark; 23C; 65% rel humidity) for 0, 3, 5, and 7 days. Biotinylated probes were synthesized from RNA isolated from manually disseted shoot meristems and hybridized to Affymetrix ATH1 arrays.

  9. The Artful Universe Expanded

    International Nuclear Information System (INIS)

    The cosmos is an awfully big place and there is no better guide to its vast expanse and fascinating nooks and crannies than John Barrow. A professor of mathematical sciences at Cambridge University, Barrow embodies that rare combination of highly polished writer and expert scientist. His deft touch brings together the disparate threads of human knowledge and weaves them into a tapestry as rich and interesting for the expert as it is for the layperson. The Artful Universe Expanded is an updated edition of this popular book first published in 1995. It explores the deeply profound manner in which natural law and the nature of the cosmos have moulded and shaped us, our cultures and the very form of our arts and music-a new type of 'cosmic' anthropology. The main themes Barrow chooses for revealing this new anthropology are the subjects of evolution, the size of things, the heavens and the nature of music. The book is a large, eclectic repository of knowledge often unavailable to the layperson, hidden in esoteric libraries around the world. It rivals The Da Vinci Code for entertainment value and insights, but this time it is Nature's code that is revealed. It is rare indeed to find common threads drawn through topics as diverse as The Beetles, Bach and Beethoven or between Jackson Pollock, the Aztecs, Kant, Picasso, Byzantine mosaics, uranium-235 and the helix nebula. Barrow unerringly binds them together, presenting them in a stimulating, conversational style that belies the amount of time that must have gone into researching this book. Dip into it at random, or read it from cover to cover, but do read it. The Artful Universe Expanded is an entertaining antidote to the oft-lamented pressures to know more and more about less and less and the apparently inexorable march of specialization. On reading this book one can, for a short time at least, hold in one's mind a vision that unifies science, art and culture and glimpse a universal tapestry of great beauty. (book review)

  10. The Artful Universe Expanded

    Energy Technology Data Exchange (ETDEWEB)

    Bassett, B A [Institute of Cosmology and Gravitation, University of Portsmouth (United Kingdom)

    2005-07-29

    The cosmos is an awfully big place and there is no better guide to its vast expanse and fascinating nooks and crannies than John Barrow. A professor of mathematical sciences at Cambridge University, Barrow embodies that rare combination of highly polished writer and expert scientist. His deft touch brings together the disparate threads of human knowledge and weaves them into a tapestry as rich and interesting for the expert as it is for the layperson. The Artful Universe Expanded is an updated edition of this popular book first published in 1995. It explores the deeply profound manner in which natural law and the nature of the cosmos have moulded and shaped us, our cultures and the very form of our arts and music-a new type of 'cosmic' anthropology. The main themes Barrow chooses for revealing this new anthropology are the subjects of evolution, the size of things, the heavens and the nature of music. The book is a large, eclectic repository of knowledge often unavailable to the layperson, hidden in esoteric libraries around the world. It rivals The Da Vinci Code for entertainment value and insights, but this time it is Nature's code that is revealed. It is rare indeed to find common threads drawn through topics as diverse as The Beetles, Bach and Beethoven or between Jackson Pollock, the Aztecs, Kant, Picasso, Byzantine mosaics, uranium-235 and the helix nebula. Barrow unerringly binds them together, presenting them in a stimulating, conversational style that belies the amount of time that must have gone into researching this book. Dip into it at random, or read it from cover to cover, but do read it. The Artful Universe Expanded is an entertaining antidote to the oft-lamented pressures to know more and more about less and less and the apparently inexorable march of specialization. On reading this book one can, for a short time at least, hold in one's mind a vision that unifies science, art and culture and glimpse a universal tapestry of great

  11. The Artful Universe Expanded

    Science.gov (United States)

    Barrow, John D.

    2005-07-01

    Our love of art, writes John Barrow, is the end product of millions of years of evolution. How we react to a beautiful painting or symphony draws upon instincts laid down long before humans existed. Now, in this enhanced edition of the highly popular The Artful Universe , Barrow further explores the close ties between our aesthetic appreciation and the basic nature of the Universe. Barrow argues that the laws of the Universe have imprinted themselves upon our thoughts and actions in subtle and unexpected ways. Why do we like certain types of art or music? What games and puzzles do we find challenging? Why do so many myths and legends have common elements? In this eclectic and entertaining survey, Barrow answers these questions and more as he explains how the landscape of the Universe has influenced the development of philosophy and mythology, and how millions of years of evolutionary history have fashioned our attraction to certain patterns of sound and color. Barrow casts the story of human creativity and thought in a fascinating light, considering such diverse topics as our instinct for language, the origins and uses of color in nature, why we divide time into intervals as we do, the sources of our appreciation of landscape painting, and whether computer-generated fractal art is really art. Drawing on a wide variety of examples, from the theological questions raised by St. Augustine and C.S. Lewis to the relationship between the pure math of Pythagoras and the music of the Beatles, The Artful Universe Expanded covers new ground and enters a wide-ranging debate about the meaning and significance of the links between art and science.

  12. Array tomography: imaging stained arrays.

    Science.gov (United States)

    Micheva, Kristina D; O'Rourke, Nancy; Busse, Brad; Smith, Stephen J

    2010-11-01

    Array tomography is a volumetric microscopy method based on physical serial sectioning. Ultrathin sections of a plastic-embedded tissue are cut using an ultramicrotome, bonded in an ordered array to a glass coverslip, stained as desired, and imaged. The resulting two-dimensional image tiles can then be reconstructed computationally into three-dimensional volume images for visualization and quantitative analysis. The minimal thickness of individual sections permits high-quality rapid staining and imaging, whereas the array format allows reliable and convenient section handling, staining, and automated imaging. Also, the physical stability of the arrays permits images to be acquired and registered from repeated cycles of staining, imaging, and stain elution, as well as from imaging using multiple modalities (e.g., fluorescence and electron microscopy). Array tomography makes it possible to visualize and quantify previously inaccessible features of tissue structure and molecular architecture. However, careful preparation of the tissue is essential for successful array tomography; these steps can be time-consuming and require some practice to perfect. In this protocol, tissue arrays are imaged using conventional wide-field fluorescence microscopy. Images can be captured manually or, with the appropriate software and hardware, the process can be automated. PMID:21041399

  13. Array tomography: production of arrays.

    Science.gov (United States)

    Micheva, Kristina D; O'Rourke, Nancy; Busse, Brad; Smith, Stephen J

    2010-11-01

    Array tomography is a volumetric microscopy method based on physical serial sectioning. Ultrathin sections of a plastic-embedded tissue are cut using an ultramicrotome, bonded in an ordered array to a glass coverslip, stained as desired, and imaged. The resulting two-dimensional image tiles can then be reconstructed computationally into three-dimensional volume images for visualization and quantitative analysis. The minimal thickness of individual sections permits high-quality rapid staining and imaging, whereas the array format allows reliable and convenient section handling, staining, and automated imaging. Also, the physical stability of the arrays permits images to be acquired and registered from repeated cycles of staining, imaging, and stain elution, as well as from imaging using multiple modalities (e.g., fluorescence and electron microscopy). Array tomography makes it possible to visualize and quantify previously inaccessible features of tissue structure and molecular architecture. However, careful preparation of the tissue is essential for successful array tomography; these steps can be time consuming and require some practice to perfect. This protocol describes the sectioning of embedded tissues and the mounting of the serial arrays. The procedures require some familiarity with the techniques used for ultramicrotome sectioning for electron microscopy. PMID:21041397

  14. TiArA: a virtual appliance for the analysis of Tiling Array data.

    Directory of Open Access Journals (Sweden)

    Jason A Greenbaum

    Full Text Available BACKGROUND: Genomic tiling arrays have been described in the scientific literature since 2003, yet there is a shortage of user-friendly applications available for their analysis. METHODOLOGY/PRINCIPAL FINDINGS: Tiling Array Analyzer (TiArA is a software program that provides a user-friendly graphical interface for the background subtraction, normalization, and summarization of data acquired through the Affymetrix tiling array platform. The background signal is empirically measured using a group of nonspecific probes with varying levels of GC content and normalization is performed to enforce a common dynamic range. CONCLUSIONS/SIGNIFICANCE: TiArA is implemented as a standalone program for Linux systems and is available as a cross-platform virtual machine that will run under most modern operating systems using virtualization software such as Sun VirtualBox or VMware. The software is available as a Debian package or a virtual appliance at http://purl.org/NET/tiara.

  15. Development and preliminary evaluation of a 90 K Axiom® SNP array for the allo-octoploid cultivated strawberry Fragaria × ananassa

    OpenAIRE

    Bassil, Nahla V.; Davis, Thomas M; Zhang, Hailong; Ficklin, Stephen; Mittmann, Mike; Webster, Teresa; Mahoney, Lise L.; Wood, David; Alperin, Elisabeth S; Umesh R Rosyara; Koehorst-vanc Putten, Herma; Monfort, Amparo; Sargent, Daniel J.; Amaya, Iraida; Denoyes, Beatrice

    2015-01-01

    Background A high-throughput genotyping platform is needed to enable marker-assisted breeding in the allo-octoploid cultivated strawberry Fragaria × ananassa. Short-read sequences from one diploid and 19 octoploid accessions were aligned to the diploid Fragaria vesca ‘Hawaii 4’ reference genome to identify single nucleotide polymorphisms (SNPs) and indels for incorporation into a 90 K Affymetrix® Axiom® array. We report the development and preliminary evaluation of this array. Results About 3...

  16. Trivalent expanders and hyperbolic surfaces

    CERN Document Server

    Ivrissimtzis, Ioannis; Vdovina, Alina

    2012-01-01

    We introduce a family of trivalent expanders which tessellate compact hyperbolic surfaces with large isometry groups. We compare this family with Platonic graphs and modifications of them and prove topological and spectral properties of these families.

  17. Helical Screw Expander Evaluation Project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    McKay, R.

    1982-03-01

    A functional 1-MW geothermal electric power plant that featured a helical screw expander was produced and then tested in Utah in 1978 to 1979 with a demonstrated average performance of approximately 45% machine efficiency over a wide range of test conditions in noncondensing operation on two-phase geothermal fluids. The Project also produced a computer-equipped data system, an instrumentation and control van, and a 1000-kW variable load bank, all integrated into a test array designed for operation at a variety of remote test sites. Additional testing was performed in Mexico in 1980 under a cooperative test program using the same test array, and machine efficiency was measured at 62% maximum with the rotors partially coated with scale, compared with approximately 54% maximum in Utah with uncoated rotors, confirming the importance of scale deposits within the machine on performance. Data are presented for the Utah testing and for the noncondensing phases of the testing in Mexico. Test time logged was 437 hours during the Utah tests and 1101 hours during the Mexico tests.

  18. Comparison of Nanostring nCounter® Data on FFPE Colon Cancer Samples and Affymetrix Microarray Data on Matched Frozen Tissues.

    Directory of Open Access Journals (Sweden)

    Xi Chen

    Full Text Available The prognosis of colorectal cancer (CRC stage II and III patients remains a challenge due to the difficulties of finding robust biomarkers suitable for testing clinical samples. The majority of published gene signatures of CRC have been generated on fresh frozen colorectal tissues. Because collection of frozen tissue is not practical for routine surgical pathology practice, a clinical test that improves prognostic capabilities beyond standard pathological staging of colon cancer will need to be designed for formalin-fixed paraffin-embedded (FFPE tissues. The NanoString nCounter® platform is a gene expression analysis tool developed for use with FFPE-derived samples. We designed a custom nCounter® codeset based on elements from multiple published fresh frozen tissue microarray-based prognostic gene signatures for colon cancer, and we used this platform to systematically compare gene expression data from FFPE with matched microarray array data from frozen tissues. Our results show moderate correlation of gene expression between two platforms and discovery of a small subset of genes as candidate biomarkers for colon cancer prognosis that are detectable and quantifiable in FFPE tissue sections.

  19. ERBU, Expanding Rubber Band Universe

    CERN Document Server

    Soares, Domingos

    2015-01-01

    I put forward a simple unidimensional mechanical analogue of the three-dimensional universe models of modern relativistic cosmology. The main goal of the proposal is the appropriate appreciation of the intrinsic relationship between Hubble's law and the homogeneity of expanding relativistic models.

  20. Expanding the eukaryotic genetic code

    Energy Technology Data Exchange (ETDEWEB)

    Chin, Jason W; Cropp, T. Ashton; Anderson, J. Christopher; Schultz, Peter G

    2015-02-03

    This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.

  1. Expanding the eukaryotic genetic code

    Science.gov (United States)

    Chin, Jason W.; Cropp, T. Ashton; Anderson, J. Christopher; Schultz, Peter G.

    2013-01-22

    This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.

  2. Introduction to parallel algorithms and architectures arrays, trees, hypercubes

    CERN Document Server

    Leighton, F Thomson

    1991-01-01

    Introduction to Parallel Algorithms and Architectures: Arrays Trees Hypercubes provides an introduction to the expanding field of parallel algorithms and architectures. This book focuses on parallel computation involving the most popular network architectures, namely, arrays, trees, hypercubes, and some closely related networks.Organized into three chapters, this book begins with an overview of the simplest architectures of arrays and trees. This text then presents the structures and relationships between the dominant network architectures, as well as the most efficient parallel algorithms for

  3. Expanding the Game Design Space

    DEFF Research Database (Denmark)

    Larsen, Lasse Juel; Majgaard, Gunver

    2016-01-01

    This article considers game design research in educational settings. Its focus is on how undergraduate students – particularly engineering students – learn computer game design. From observations conducted during our game design courses we have developed a model of expanded game design space....... It encapsulates the entire development process from the first ideas to the final game with emphasis on game design thinking. Our model of expanded game design space consists of four separate – yet interconnected – layers in the process of game development. The first layer addresses the importance of framing......, providing a clear game design assignment that involves the formulation of intended player experience and a description of game mechanics. The second layer focuses on game design thinking from six different aspects of game design chosen in relation to the framing of the game design assignment. The third...

  4. Expanding the Game Design Space

    DEFF Research Database (Denmark)

    Larsen, Lasse Juel; Majgaard, Gunver

    2016-01-01

    This article considers game design research in educational settings. Its focus is on how undergraduate students – particularly engineering students – learn computer game design. From observations conducted during our game design courses we have developed a model of expanded game design space. It...... encapsulates the entire development process from the first ideas to the final game with emphasis on game design thinking. Our model of expanded game design space consists of four separate – yet interconnected – layers in the process of game development. The first layer addresses the importance of framing...... layer establishes correspondence between formal elements of computer games and the structure of problem-based creativity. It addresses how game design challenges should be formulated and how creative solutions can be measured. The fourth and final layer demonstrates how clear framing can act as a...

  5. Durability of expanded polystyrene mortars

    OpenAIRE

    Ferrándiz Mas, Verónica; García Alcocel, Eva María

    2013-01-01

    The influence of the addition of various types and various concentrations of expanded polystyrene foam (both commercial and recycled) on the durability of Portland cement mortars is studied. In particular, the microstructure is studied utilizing the following methods: capillary absorption of water, mercury intrusion porosimetry, impedance spectroscopy and open porosity. In addition, the effects of heat cycles and freeze–thaw cycles on compressive strength are examined. Scanning electron micro...

  6. Relativistically expanding cylindrical electromagnetic fields

    OpenAIRE

    Gourgouliatos, K. N.

    2009-01-01

    We study relativistically expanding electromagnetic fields of cylindrical geometry. The fields emerge from the side surface of a cylinder and are invariant under translations parallel to the axis of the cylinder. The expansion velocity is in the radial direction and is parametrized by $v=R/(ct)$. We consider force-free magnetic fields by setting the total force the electromagnetic field exerts on the charges and the currents equal to zero. Analytical and semi-analytical separable solutions ar...

  7. Entanglement in an expanding spacetime

    International Nuclear Information System (INIS)

    We show that a dynamical spacetime generates entanglement between modes of a quantum field. Conversely, the entanglement encodes information concerning the underlying spacetime structure, which hints at the prospect of applications of this observation to cosmology. Here we illustrate this point by way of an analytically exactly soluble example, that of a scalar quantum field on a two-dimensional asymptotically flat Robertson-Walker expanding spacetime. We explicitly calculate the entanglement in the far future, for a quantum field residing in the vacuum state in the distant past. In this toy universe, it is possible to fully reconstruct the parameters of the cosmic history from the entanglement entropy

  8. Who discovered the expanding universe?

    CERN Document Server

    Nussbaumer, Harry

    2011-01-01

    Who discovered the expanding universe? Was it Hubble, or Lemaitre, or was it just the end result of a long series of investigations? In this article we summarise the main steps and contributions that led to one of the most exciting discoveries ever made, of which Lemaitre was the principal architect. In 1927 he combined his dynamical solutions of the Einstein equations with astronomical observations to conclude that the universe is expanding. He derived the linear velocity-distance relationship and calculated the first numerical value of what later was called the "Hubble constant". His discovery paper of 1927 was written in French and in 1931 it was translated into English and published in Monthly Notices. However, the translation omits the section where Lemaitre computed the "Hubble constant". Why was that done, and who was responsible? We do not speculate on this question, but present in a very condensed way the facts along the path of discovery. The documented details from primary sources can be found in o...

  9. Analysis of Chinese women with primary ovarian insufficiency by high resolution array-comparative genomic hybridization

    Institute of Scientific and Technical Information of China (English)

    LIAO Can; FU Fang; YANG Xin; SUN Yi-min; LI Dong-zhi

    2011-01-01

    Background Primary ovarian insufficiency (POI) is defined as a primary ovarian defect characterized by absent menarche (primary amenorrhea) or premature depletion of ovarian follicles before the age of 40 years. The etiology of primary ovarian insufficiency in human female patients is still unclear. The purpose of this study is to investigate the potential genetic causes in primary amenorrhea patients by high resolution array based comparative genomic hybridization (array-CGH) analysis.Methods Following the standard karyotyping analysis, genomic DNA from whole blood of 15 primary amenorrhea patients and 15 normal control women was hybridized with Affymetrix cytogenetic 2.7M arrays following the standard protocol. Copy number variations identified by array-CGH were confirmed by real time polymerase chain reaction.Results All the 30 samples were negative by conventional karyotyping analysis. Microdeletions on chromosome 17q21.31-q21.32 with approximately 1.3 Mb were identified in four patients by high resolution array-CGH analysis. This included the female reproductive secretory pathway related factor N-ethylmaleimide-sensitive factor (NSF) gene.Conclusions The results of the present study suggest that there may be critical regions regulating primary ovarian insufficiency in women with a 17q21.31-q21.32 microdeletion. This effect might be due to the loss of function of the NSF gene/genes within the deleted region or to effects on contiguous genes.

  10. Expanding radio astronomy in Africa

    International Nuclear Information System (INIS)

    The Square Kilometre Array (SKA) Organisation announced in May 2012 that its members had agreed on a dual site solution for the SKA [1]. South Africa's bid for hosting the SKA has caused a ramp up of radio astronomy in Africa. To develop technology towards the SKA, the South African SKA Project (SKA SA) built a protoype radio telescope in 2007, followed in 2010 the seven antenna Karoo Array Telescope (KAT-7). Next is the 64 antenna MeerKAT, which will merge into SKA Phase 1 in Africa. As SKA Phase 2 is intended to add a high resolution capability with baselines out to 3000 km, the SKA SA brought in partner countries in Africa to host outstations. South Africa has been working with the partners to build capacity to operate the SKA and to benefit from it. The SA Department of Science and Technology (DST) developed a proposal to establish radio telescopes in the partner countries to provide hands-on learning and a capability for Very Long Baseline Interferometry (VLBI) research. Redundant 30 m class satellite antennas are being incorporated in this project.

  11. Genome-wide mapping of copy number variation in humans: comparative analysis of high resolution array platforms.

    Directory of Open Access Journals (Sweden)

    Rajini R Haraksingh

    Full Text Available Accurate and efficient genome-wide detection of copy number variants (CNVs is essential for understanding human genomic variation, genome-wide CNV association type studies, cytogenetics research and diagnostics, and independent validation of CNVs identified from sequencing based technologies. Numerous, array-based platforms for CNV detection exist utilizing array Comparative Genome Hybridization (aCGH, Single Nucleotide Polymorphism (SNP genotyping or both. We have quantitatively assessed the abilities of twelve leading genome-wide CNV detection platforms to accurately detect Gold Standard sets of CNVs in the genome of HapMap CEU sample NA12878, and found significant differences in performance. The technologies analyzed were the NimbleGen 4.2 M, 2.1 M and 3×720 K Whole Genome and CNV focused arrays, the Agilent 1×1 M CGH and High Resolution and 2×400 K CNV and SNP+CGH arrays, the Illumina Human Omni1Quad array and the Affymetrix SNP 6.0 array. The Gold Standards used were a 1000 Genomes Project sequencing-based set of 3997 validated CNVs and an ultra high-resolution aCGH-based set of 756 validated CNVs. We found that sensitivity, total number, size range and breakpoint resolution of CNV calls were highest for CNV focused arrays. Our results are important for cost effective CNV detection and validation for both basic and clinical applications.

  12. Expanding Human Cognition and Communication

    Energy Technology Data Exchange (ETDEWEB)

    Spohrer, Jim [IBM, North Castle, NY (United States); Pierce, Brian M. [Raytheon Co., Waltham, MA (United States); Murray, Cherry A. [Lucent Technologies, Murray Hill, NJ (United States); Golledge, Reginald G. [Univ. of California, Santa Barbara, CA (United States); Horn, Robert E. [Stanford Univ., CA (United States); Turkle, Sherry [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Yonas, Gerold [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Glicken Turnley, Jessica [Galisteo Consulting Group, Inc., Albuquerque, NM (United States); Pollack, Jordan [Brandeis Univ., Waltham, MA (United States); Burger, Rudy [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Robinett, Warren; Wilson, Larry Todd [Inst. of Electrical and Electronics Engineers (IEEE), Piscataway, NJ (United States); Bainbridge, W. S.; Canton, J.; Kuekes, P.; Loomis, J.; Penz, P.

    2013-01-01

    To be able to chart the most profitable future directions for societal transformation and corresponding scientific research, five multidisciplinary themes focused on major goals have been identified to fulfill the overall motivating vision of convergence described in the previous pages. The first, “Expanding Human Cognition and Communication,” is devoted to technological breakthroughs that have the potential to enhance individuals’ mental and interaction abilities. Throughout the twentieth century, a number of purely psychological techniques were offered for strengthening human character and personality, but evaluation research has generally failed to confirm the alleged benefits of these methods (Druckman and Bjork 1992; 1994). Today, there is good reason to believe that a combination of methods, drawing upon varied branches of converging science and technology, would be more effective than attempts that rely upon mental training alone.

  13. Expanding the Trilinos developer community.

    Energy Technology Data Exchange (ETDEWEB)

    Heroux, Michael Allen

    2010-10-01

    The Trilinos Project started approximately nine years ago as a small effort to enable research, development and ongoing support of small, related solver software efforts. The 'Tri' in Trilinos was intended to indicate the eventual three packages we planned to develop. In 2007 the project expanded its scope to include any package that was an enabling technology for technical computing. Presently the Trilinos repository contains over 55 packages covering a broad spectrum of reusable tools for constructing full-featured scalable scientific and engineering applications. Trilinos usage is now worldwide, and many applications have an explicit dependence on Trilinos for essential capabilities. Users come from other US laboratories, universities, industry and international research groups. Awareness and use of Trilinos is growing rapidly outside of Sandia. Members of the external research community are becoming more familiar with Trilinos, its design and collaborative nature. As a result, the Trilinos project is receiving an increasing number of requests from external community members who want to contribute to Trilinos as developers. To-date we have worked with external developers in an ad hoc fashion. Going forward, we want to develop a set of policies, procedures, tools and infrastructure to simplify interactions with external developers. As we go forward with multi-laboratory efforts such as CASL and X-Stack, and international projects such as IESP, we will need a more streamlined and explicit process for making external developers 'first-class citizens' in the Trilinos development community. This document is intended to frame the discussion for expanding the Trilinos community to all strategically important external members, while at the same time preserving Sandia's primary leadership role in the project.

  14. Expanding Lookout Capabilities for Architectural Analysis

    Science.gov (United States)

    Shick, B.

    SMC/SYSW/ENY's Lookout tool provides a M&S capability for architectural analysis. It models the contributions of ground and space-based assets in several mission threads and scenarios to quantify overall Space Situational Awareness (SSA) capability. Plotting performance results versus costs enables decision makers to identify and evaluate Best Value families of systems and combinations of architectures. Currently, SMC intends to use Lookout to impact the Fiscal Year 2012 budget programming cycle, the National SSA Initial Capabilities Document (ICD) and Architecture definition effort, planning for programs of record, and AFSPC & SMC leadership. Ultimately, Lookout will enable additional space superiority analysis. Previous Lookout work focused on modeling the metric tracking capabilities of the Space Surveillance Network (detecting and tracking) and proposed concepts to close identified collection shortfalls. SMC/SYSW/ENY leveraged some of the lessons learned in developing and implementing the metric tracking models to expand Lookout to develop an initial characterization capability, including non-resolved space object identification (SOI), imaging, and Foreign Instrumentation and Signals (FIS) Intelligence. Characterization collection phenomenologies added in FY08 and FY09 include mechanical tracking and phased array radars, visible telescopes, and signals collection. Lookout enables evaluating the characterization collections for quantity, quality, and timeliness. Capturing the Tasking, Collection, Processing, Exploitation, and Dissemination processes represent one of the biggest challenges in including characterization capabilities in mission thread and scenario-based analysis. The SMC/SYSW/ENY team met with several representatives of the community and held community-wide Technical Interchange Meetings. Based on feedback from these meetings, SMC created an infrastructure for modeling the tasking processes and scales to relate collection quality to intelligence

  15. An experimental reciprocating expander for cryocooler application

    Science.gov (United States)

    Minta, M.; Smith, J. L., Jr.

    1985-01-01

    An experimental reciprocating expander was designed with features appropriate for cryocooler cycles. The expander has a displacer piston, simple valves, and a hydraulic/pneumatic stroking mechanism. The expander has a valve in head configuration with the valves extending out the bottom of the vacuum enclosure while the piston extends out the top. The expander was tested using a CTI 1400 liquefier to supply 13 atm in the temperature range 4.2 to 12 K. Expander efficiency was measured in the range 84 to 93% while operating the apparatus as a supercritical wet expander and in the range 91 to 93% aa a single phase expander. The apparatus can also be modified to operate as a compressor for saturated helium vapor.

  16. Discovery of Uniformly Expanding Universe

    Directory of Open Access Journals (Sweden)

    Cahill R. T.

    2012-01-01

    Full Text Available Saul Perlmutter and the Brian Schmidt – Adam Riess teams reported that their Friedmann-model GR-based analysis of their supernovae magnitude-redshift data re- vealed a new phenomenon of “dark energy” which, it is claimed, forms 73% of the energy / matter density of the present-epoch universe, and which is linked to the further claim of an accelerating expansion of the universe. In 2011 Perlmutter, Schmidt and Riess received the Nobel Prize in Physics “for the discovery of the accelerating ex- pansion of the Universe through observations of distant supernovae”. Here it is shown that (i a generic model-independent analysis of this data reveals a uniformly expanding universe, (ii their analysis actually used Newtonian gravity, and finally (iii the data, as well as the CMB fluctuation data, does not require “dark energy” nor “dark matter”, but instead reveals the phenomenon of a dynamical space, which is absent from the Friedmann model.

  17. A multicenter, cross-platform clinical validation study of cancer cytogenomic arrays.

    Science.gov (United States)

    Li, Marilyn M; Monzon, Federico A; Biegel, Jaclyn A; Jobanputra, Vaidehi; Laffin, Jennifer J; Levy, Brynn; Leon, Annette; Miron, Patricia; Rossi, Michael R; Toruner, Gokce; Alvarez, Karla; Doho, Gregory; Dougherty, Margaret J; Hu, Xiaofeng; Kash, Shera; Streck, Deanna; Znoyko, Iya; Hagenkord, Jill M; Wolff, Daynna J

    2015-11-01

    Cytogenomic microarray analysis (CMA) offers high resolution, genome-wide copy number information and is widely used in clinical laboratories for diagnosis of constitutional abnormalities. The Cancer Genomics Consortium (CGC) conducted a multiplatform, multicenter clinical validation project to compare the reliability and inter- and intralaboratory reproducibility of this technology for clinical oncology applications. Four specimen types were processed on three different microarray platforms-from Affymetrix, Agilent, and Illumina. Each microarray platform was employed at two independent test sites. The results were compared in a blinded manner with current standard methods, including karyotype, FISH, or morphology. Twenty-nine chronic lymphocytic leukemia blood, 34 myelodysplastic syndrome bone marrow, and 30 fresh frozen renal epithelial tumor samples were assessed by all six laboratories. Thirty formalin fixed paraffin embedded renal tumor samples were analyzed at the Affymetrix and Agilent test sites only. All study samples were initial diagnostic samples. Array data were analyzed at each participating site and were submitted to caArray for central analysis. Laboratory interpretive results were submitted to the central analysis team for comparison with the standard-of-care assays and for calculation of intraplatform reproducibility and cross-platform concordance. The results demonstrated that the three microarray platforms 1) detect clinically actionable genomic changes in cancer compatible to standard-of-care methods; 2) further define cytogenetic aberrations; 3) identify submicroscopic alterations and loss of heterozygosity (LOH); and 4) yield consistent results within and between laboratories. Based on this study, the CGC concludes that CMA is a sensitive and reliable technique for copy number and LOH assessment that may be used for clinical oncology genomic analysis. PMID:26454669

  18. Expanding the Interaction Equivalency Theorem

    Directory of Open Access Journals (Sweden)

    Brenda Cecilia Padilla Rodriguez

    2015-06-01

    Full Text Available Although interaction is recognised as a key element for learning, its incorporation in online courses can be challenging. The interaction equivalency theorem provides guidelines: Meaningful learning can be supported as long as one of three types of interactions (learner-content, learner-teacher and learner-learner is present at a high level. This study sought to apply this theorem to the corporate sector, and to expand it to include other indicators of course effectiveness: satisfaction, knowledge transfer, business results and return on expectations. A large Mexican organisation participated in this research, with 146 learners, 30 teachers and 3 academic assistants. Three versions of an online course were designed, each emphasising a different type of interaction. Data were collected through surveys, exams, observations, activity logs, think aloud protocols and sales records. All course versions yielded high levels of effectiveness, in terms of satisfaction, learning and return on expectations. Yet, course design did not dictate the types of interactions in which students engaged within the courses. Findings suggest that the interaction equivalency theorem can be reformulated as follows: In corporate settings, an online course can be effective in terms of satisfaction, learning, knowledge transfer, business results and return on expectations, as long as (a at least one of three types of interaction (learner-content, learner-teacher or learner-learner features prominently in the design of the course, and (b course delivery is consistent with the chosen type of interaction. Focusing on only one type of interaction carries a high risk of confusion, disengagement or missed learning opportunities, which can be managed by incorporating other forms of interactions.

  19. Camera array based light field microscopy.

    Science.gov (United States)

    Lin, Xing; Wu, Jiamin; Zheng, Guoan; Dai, Qionghai

    2015-09-01

    This paper proposes a novel approach for high-resolution light field microscopy imaging by using a camera array. In this approach, we apply a two-stage relay system for expanding the aperture plane of the microscope into the size of an imaging lens array, and utilize a sensor array for acquiring different sub-apertures images formed by corresponding imaging lenses. By combining the rectified and synchronized images from 5 × 5 viewpoints with our prototype system, we successfully recovered color light field videos for various fast-moving microscopic specimens with a spatial resolution of 0.79 megapixels at 30 frames per second, corresponding to an unprecedented data throughput of 562.5 MB/s for light field microscopy. We also demonstrated the use of the reported platform for different applications, including post-capture refocusing, phase reconstruction, 3D imaging, and optical metrology. PMID:26417490

  20. Infrared focal plane array crosstalk measurement

    Science.gov (United States)

    Dang, Khoa V.; Kauffman, Christopher L.; Derzko, Zenon I.

    1992-07-01

    Crosstalk between two neighboring elements in a focal plane array (FPA) occurs when signal incident on one element in the array is seen on another. This undesired effect can occur due to both the electrical and optical properties of the FPA. An effort is underway at the U.S. Army's Night Vision and Electro-Optics Directorate to develop a capability to measure crosstalk on both mid-wave infrared and long-wave infrared FPAs. A single detector in an array is illuminated using a laser source coupled with a beam expander, collimating lens, and focusing lens. The relative response of that detector to that of its neighboring detectors is measured to calculate crosstalk. The various components of the test station, the methodology for implementing the crosstalk measurement, and a model of the laser spot size are discussed.

  1. Inherent-opening-controlled pattern formation in carbon nanotube arrays

    OpenAIRE

    Huang, Xiao; Zhou, Jijie J.; Sansom, Elijah; Gharib, Morteza; Haur, Sow Chorng

    2007-01-01

    We have introduced inherent openings into densely packed carbon nanotube arrays to study self-organized pattern formation when the arrays undergo a wetting–dewetting treatment from nanotube tips. These inherent openings, made of circular or elongated hollows in nanotube mats, serve as dewetting centres, from where liquid recedes from. As the dewetting centres initiate dry zones and the dry zones expand, surrounding nanotubes are pulled away from the dewetting centres by liquid surface tension...

  2. Separation of craniopagus twins utilizing tissue expanders.

    Science.gov (United States)

    Shively, R E; Bermant, M A; Bucholz, R D

    1985-11-01

    An example of craniopagus Siamese twins is presented. The methods used in their separation using skin expanders and scalp flaps to achieve primary closure of the wounds with hair-bearing scalp are outlined. A detailed discussion of the planning and the mathematical considerations of these skin expanders and scalp flaps is included. PMID:4059416

  3. Decay of correlations for nonuniformly expanding systems

    OpenAIRE

    Gouezel, Sebastien

    2004-01-01

    We estimate the speed of decay of correlations for general nonuniformly expanding dynamical systems, using estimates on the time the system takes to become really expanding. Our method can deal with fast decays, such as exponential or stretched exponential. We prove in particular that the correlations of the Alves-Viana map decay in $O(e^{-c \\sqrt{n}})$.

  4. Super phase array

    Energy Technology Data Exchange (ETDEWEB)

    Wee, W H; Pendry, J B [Condensed Matter Theory Group Department of Physics Imperial College London London SW7 2AZ (United Kingdom)], E-mail: w.wee07@imperial.ac.uk

    2010-03-15

    For a long time phase arrays have been used in a variety of wave transmission applications because of their simplicity and versatility. Conventionally there is a trade-off between the compactness of a phase array and its directivity. In this paper we demonstrate how by embedding a normal phase array within a superlens (made of negative refractive index material) we can overcome this constraint and create compact phase arrays with a virtual extent much larger than the physical size of the array. In this paper we also briefly discuss the apparent unphysical field divergences in superlenses and how to resolve this issue.

  5. Super phase array

    International Nuclear Information System (INIS)

    For a long time phase arrays have been used in a variety of wave transmission applications because of their simplicity and versatility. Conventionally there is a trade-off between the compactness of a phase array and its directivity. In this paper we demonstrate how by embedding a normal phase array within a superlens (made of negative refractive index material) we can overcome this constraint and create compact phase arrays with a virtual extent much larger than the physical size of the array. In this paper we also briefly discuss the apparent unphysical field divergences in superlenses and how to resolve this issue.

  6. Screw expander for light duty diesel engines

    Science.gov (United States)

    1983-01-01

    Preliminary selection and sizing of a positive displacement screw compressor-expander subsystem for a light-duty adiabatic diesel engine; development of a mathematical model to describe overall efficiencies for the screw compressor and expander; simulation of operation to establish overall efficiency for a range of design parameters and at given engine operating points; simulation to establish potential net power output at light-duty diesel operating points; analytical determination of mass moments of inertia for the rotors and inertia of the compressor-expander subsystem; and preparation of engineering layout drawings of the compressor and expander are discussed. As a result of this work, it was concluded that the screw compressor and expander designed for light-duty diesel engine applications are viable alternatives to turbo-compound systems, with acceptable efficiencies for both units, and only a moderate effect on the transient response.

  7. Tissue Expander versus Tissue Expander and Latissimus Flap in Morbidly Obese Breast Reconstruction Patients

    Directory of Open Access Journals (Sweden)

    Edward A. Luce, MD

    2015-03-01

    Conclusion: The loss rate in immediate postmastectomy reconstruction in morbidly obese patients with latissimus flap plus tissue expander was substantially lower than the loss rate in those with breast reconstructed with tissue expander alone.

  8. The Colorado Lightning Mapping Array

    Science.gov (United States)

    Rison, W.; Krehbiel, P. R.; Thomas, R. J.; Rodeheffer, D.; Fuchs, B.

    2012-12-01

    A fifteen station Lightning Mapping Array (LMA) was installed in northern Colorado in the spring of 2012. While the driving force for the array was to produce 3-dimensional lightning data to support the Deep Convective Clouds and Chemistry (DC3) Experiment (Barth, this conference), data from the array are being used for several other projects. These include: electrification studies in conjunction with the CSU CHILL radar (Lang et al, this conference); observations of the parent lightning discharges of sprites (Lyons et al, this conference); trying to detect upward discharges triggered by wind turbines, characterizing conditions in which aircraft flying through clouds produce discharges which can be detected by the LMA, and other opportunities, such as observations of lightning in pyrocumulus clouds produced by the High Park Fire west of Fort Collins, CO. All the COLMA stations are solar-powered, and use broadband cellular modems for data communications. This makes the stations completely self-contained and autonomous, allowing a station to be installed anywhere a cellular signal is available. Because most of the stations were installed well away from anthropogenic noise sources, the COLMA is very sensitive. This is evidenced by the numerous plane tracks detected in its the vicinity. The diameter, D, of the COLMA is about 100 km, significantly larger than other LMAs. Because the error in the radial distance r is proportional to (r/D)2, and the error in the altitude z is proportional to (z/D)2, the larger array diameter greatly expands the usable range of the COLMA. The COLMA is able to detect and characterize lighting flashes to a distance of about 350 km from the array center. In addition to a web-based display (lightning.nmt.edu/colma), geo-referenced images are produced and updated at one-minute intervals. These geo-referenced images can be used to overlay the real-time lightning data on Google Earth and other mapping software. These displays were used by the DC3

  9. ExonMiner: Web service for analysis of GeneChip Exon array data

    Directory of Open Access Journals (Sweden)

    Imoto Seiya

    2008-11-01

    Full Text Available Abstract Background Some splicing isoform-specific transcriptional regulations are related to disease. Therefore, detection of disease specific splice variations is the first step for finding disease specific transcriptional regulations. Affymetrix Human Exon 1.0 ST Array can measure exon-level expression profiles that are suitable to find differentially expressed exons in genome-wide scale. However, exon array produces massive datasets that are more than we can handle and analyze on personal computer. Results We have developed ExonMiner that is the first all-in-one web service for analysis of exon array data to detect transcripts that have significantly different splicing patterns in two cells, e.g. normal and cancer cells. ExonMiner can perform the following analyses: (1 data normalization, (2 statistical analysis based on two-way ANOVA, (3 finding transcripts with significantly different splice patterns, (4 efficient visualization based on heatmaps and barplots, and (5 meta-analysis to detect exon level biomarkers. We implemented ExonMiner on a supercomputer system in order to perform genome-wide analysis for more than 300,000 transcripts in exon array data, which has the potential to reveal the aberrant splice variations in cancer cells as exon level biomarkers. Conclusion ExonMiner is well suited for analysis of exon array data and does not require any installation of software except for internet browsers. What all users need to do is to access the ExonMiner URL http://ae.hgc.jp/exonminer. Users can analyze full dataset of exon array data within hours by high-level statistical analysis with sound theoretical basis that finds aberrant splice variants as biomarkers.

  10. Carbon nanotube nanoelectrode arrays

    Science.gov (United States)

    Ren, Zhifeng; Lin, Yuehe; Yantasee, Wassana; Liu, Guodong; Lu, Fang; Tu, Yi

    2008-11-18

    The present invention relates to microelectode arrays (MEAs), and more particularly to carbon nanotube nanoelectrode arrays (CNT-NEAs) for chemical and biological sensing, and methods of use. A nanoelectrode array includes a carbon nanotube material comprising an array of substantially linear carbon nanotubes each having a proximal end and a distal end, the proximal end of the carbon nanotubes are attached to a catalyst substrate material so as to form the array with a pre-determined site density, wherein the carbon nanotubes are aligned with respect to one another within the array; an electrically insulating layer on the surface of the carbon nanotube material, whereby the distal end of the carbon nanotubes extend beyond the electrically insulating layer; a second adhesive electrically insulating layer on the surface of the electrically insulating layer, whereby the distal end of the carbon nanotubes extend beyond the second adhesive electrically insulating layer; and a metal wire attached to the catalyst substrate material.

  11. A Study of Flexible Composites for Expandable Space Structures

    Science.gov (United States)

    Scotti, Stephen J.

    2016-01-01

    Payload volume for launch vehicles is a critical constraint that impacts spacecraft design. Deployment mechanisms, such as those used for solar arrays and antennas, are approaches that have successfully accommodated this constraint, however, providing pressurized volumes that can be packaged compactly at launch and expanded in space is still a challenge. One approach that has been under development for many years is to utilize softgoods - woven fabric for straps, cloth, and with appropriate coatings, bladders - to provide this expandable pressure vessel capability. The mechanics of woven structure is complicated by a response that is nonlinear and often nonrepeatable due to the discrete nature of the woven fiber architecture. This complexity reduces engineering confidence to reliably design and certify these structures, which increases costs due to increased requirements for system testing. The present study explores flexible composite materials systems as an alternative to the heritage softgoods approach. Materials were obtained from vendors who utilize flexible composites for non-aerospace products to determine some initial physical and mechanical properties of the materials. Uniaxial mechanical testing was performed to obtain the stress-strain response of the flexible composites and the failure behavior. A failure criterion was developed from the data, and a space habitat application was used to provide an estimate of the relative performance of flexible composites compared to the heritage softgoods approach. Initial results are promising with a 25% mass savings estimated for the flexible composite solution.

  12. Dual-action expanded-latch mechanism

    Science.gov (United States)

    Spencer, R. A.; Tewell, J. R.; Tobey, W. H.

    1978-01-01

    Single drive actuator operates novel mechanism that expands, attaches to object, and withdraws to latch object firmly to another part. Packaging is extremely simple and compact, and eliminates need for machined parts or close tolerances.

  13. Expanding Patient Options: Minilaparotomy for Hysterectomy

    Medline Plus

    Full Text Available Expanding Patient Options: Minilaparotomy for Hysterectomy Covidien Energy Based Devices Concord, California May 26, 2010 Welcome to this OR ... a procedure that is very cost effective and patient friendly. Our agenda tonight is as follows: I’ ...

  14. Expanding Patient Options: Minilaparotomy for Hysterectomy

    Medline Plus

    Full Text Available ... fear that will have some injury to surrounding tissue. There may be some fear of uncontrolled bleeding ... small incision. But once you start expanding the tissues and putting that Alexis retractor in, you actually ...

  15. Expanding Patient Options: Minilaparotomy for Hysterectomy

    Medline Plus

    Full Text Available Expanding Patient Options: Minilaparotomy for Hysterectomy Covidien Energy Based Devices Concord, California May 26, 2010 Welcome to this OR Live program presented by Covidien energy-based devices. Good evening, and thank ...

  16. Expanding Literacy and Integrating Curricula through Dance.

    Science.gov (United States)

    Birch, James R.

    2000-01-01

    Dance embodies all of the multiple intelligences and uses Sternberg's intellectual components (memory, analysis, creativity, practicality). Integrated into the curriculum, dance can expand literacy and make learning more interactive. (SK)

  17. Expandable intramedullary nail - experimental biomechanical evaluation

    OpenAIRE

    A. Kajzer; W. Kajzer; J. Marciniak

    2010-01-01

    Purpose: The paper presents results of experimental analysis of femur and femur – expandable intramedullary nail system. The aim of the work was to determine displacement in three models. In addition, the torsion of the system aiming at determining the moments depending on the torsional angle of the bone was carried out.Design/methodology/approach: Three femurs were selected for studies. The analysis was carried out on the femur – expandable intramedullary nail system. The influence of the lo...

  18. Expanding traumatic intracerebral contusion/hematoma

    Directory of Open Access Journals (Sweden)

    Yadav Yad

    2006-01-01

    Full Text Available Background and Aims: Delayed traumatic hematomas and expansion of already detected hematomas are not uncommon. Only few studies are available on risk factors of expanding hematomas. A prospective study was aimed to find out risk factors associated with such traumatic lesions. Materials and Methods: Present study is based on 262 cases of intracerebral hematomas / contusions out of which 43 (16.4% hematomas expanded in size. computerized tomography (CT scan was done in all the patients at the time of admission and within 24 hours of injury. Repeat CT scan was done within 24 hours, 4 days and 7 days. Midline shift if any, prothrombin time, activated partial thromboplastin time, bleeding time, clotting time and platelet counts, Glasgow coma scale at admission and discharge and Glasgow outcome score at 6 months follow up were recorded. Results: Twenty six percent, 11.3 and 0% patients developed expanding hematoma in Glasgow Coma scale (GCS of 8 and below, 9-12 and 13-15 respectively. The chances of expanding hematomas were higher in patients with other associated hematomas (17.4% as compared to isolated hematoma (4.8% (Fisher′s exact results P =0.216. All the cases of expanding hematoma had some degree of midline shift and considerably higher proportion had presence of coagulopathy. The results of logistic regression analysis showed GCS, midline shift and coagulopathy as significant predictors for the expanding hematoma. Thirty nine patients (90.7% of the total expanding hematomas developed within 24 hours of injury. Conclusions: Enlargement of intracerebral hematomas is quite common and majority of them expand early after the injury. These lesions were common in patients with poor GCS, associated hematomas, associated coagulopathy and midline shift.

  19. Molecular dynamics simulation of expanding infinite matter

    International Nuclear Information System (INIS)

    Multi-fragmentation occurred in an expanding infinite system is studied by using molecular dynamics simulation. To evaluate the secondary decay effect, the time evolution of expanding system is proceeded till all fragments are stabilized completely. The fragment mass distribution from the expansion is compared with a percolation model and the cause of the exponential shape is clarified. The cause of small critical temperature is also discussed. (author)

  20. Expandability, Reversibility, and Optimal Capacity Choice

    OpenAIRE

    Dixit, Avinash K; Robert S. Pindyck

    1998-01-01

    We develop continuous-time models of capacity choice when demand fluctuates stochastically, and the firm's opportunities to expand or contract are limited. Specifically consider costs of investing or disinvesting that vary with time, or with the amount of capacity already installed. The firm's limited opportunities to expand or contract create call and put options on incremental units of capital; we show how the values of these options affect the firm's investment decisions.

  1. Dynamical Model of an Expanding Shell

    OpenAIRE

    Pe'er, Asaf

    2012-01-01

    Expanding blast waves are ubiquitous in many astronomical sources, such as supernovae remnants (SNRs), X-ray emitting binaries (XRBs) and gamma-ray bursts (GRBs). I consider here the dynamics of such an expanding blast wave, both in the adiabatic and the radiative regimes. As the blast wave collects material from the surrounding, it decelerates. A full description of the temporal evolution of the blast wave requires consideration of both the energy density and the pressure of the shocked mate...

  2. Automated SNP Genotype Clustering Algorithm to Improve Data Completeness in High-Throughput SNP Genotyping Datasets from Custom Arrays

    Institute of Scientific and Technical Information of China (English)

    Edward; M.; Smith; Jack; Littrell; Michael; Olivier

    2007-01-01

    High-throughput SNP genotyping platforms use automated genotype calling algo- rithms to assign genotypes. While these algorithms work efficiently for individual platforms, they are not compatible with other platforms, and have individual biases that result in missed genotype calls. Here we present data on the use of a second complementary SNP genotype clustering algorithm. The algorithm was originally designed for individual fluorescent SNP genotyping assays, and has been opti- mized to permit the clustering of large datasets generated from custom-designed Affymetrix SNP panels. In an analysis of data from a 3K array genotyped on 1,560 samples, the additional analysis increased the overall number of genotypes by over 45,000, significantly improving the completeness of the experimental data. This analysis suggests that the use of multiple genotype calling algorithms may be ad- visable in high-throughput SNP genotyping experiments. The software is written in Perl and is available from the corresponding author.

  3. ISS Solar Array Management

    Science.gov (United States)

    Williams, James P.; Martin, Keith D.; Thomas, Justin R.; Caro, Samuel

    2010-01-01

    The International Space Station (ISS) Solar Array Management (SAM) software toolset provides the capabilities necessary to operate a spacecraft with complex solar array constraints. It monitors spacecraft telemetry and provides interpretations of solar array constraint data in an intuitive manner. The toolset provides extensive situational awareness to ensure mission success by analyzing power generation needs, array motion constraints, and structural loading situations. The software suite consists of several components including samCS (constraint set selector), samShadyTimers (array shadowing timers), samWin (visualization GUI), samLock (array motion constraint computation), and samJet (attitude control system configuration selector). It provides high availability and uptime for extended and continuous mission support. It is able to support two-degrees-of-freedom (DOF) array positioning and supports up to ten simultaneous constraints with intuitive 1D and 2D decision support visualizations of constraint data. Display synchronization is enabled across a networked control center and multiple methods for constraint data interpolation are supported. Use of this software toolset increases flight safety, reduces mission support effort, optimizes solar array operation for achieving mission goals, and has run for weeks at a time without issues. The SAM toolset is currently used in ISS real-time mission operations.

  4. Array for detecting microbes

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, Gary L.; DeSantis, Todd D.

    2014-07-08

    The present embodiments relate to an array system for detecting and identifying biomolecules and organisms. More specifically, the present embodiments relate to an array system comprising a microarray configured to simultaneously detect a plurality of organisms in a sample at a high confidence level.

  5. Micromachined electrode array

    Energy Technology Data Exchange (ETDEWEB)

    Okandan, Murat (Edgewood, NM); Wessendorf, Kurt O. (Albuquerque, NM)

    2007-12-11

    An electrode array is disclosed which has applications for neural stimulation and sensing. The electrode array, in certain embodiments, can include a plurality of electrodes each of which is flexibly attached to a common substrate using a plurality of springs to allow the electrodes to move independently. In other embodiments of the electrode array, the electrodes can be fixed to the substrate. The electrode array can be formed from a combination of bulk and surface micromachining, and can include electrode tips having an electroplated metal (e.g. platinum, iridium, gold or titanium) or a metal oxide (e.g. iridium oxide) for biocompatibility. The electrode array can be used to form a part of a neural prosthesis, and is particularly well adapted for use in an implantable retinal prosthesis.

  6. Diode Laser Arrays

    Science.gov (United States)

    Botez, Dan; Scifres, Don R.

    1994-08-01

    This book provides a comprehensive overview of the fundamental principles and applications of semiconductor diode laser arrays. All of the major types of arrays are discussed in detail, including coherent, incoherent, edge- and surface-emitting, horizontal- and vertical-cavity, individually addressed, lattice- matched and strained-layer systems. The initial chapters cover such topics as lasers, amplifiers, external-cavity control, theoretical modeling, and operational dynamics. Spatially incoherent arrays are then described in detail, and the uses of vertical-cavity surface emitter and edge-emitting arrays in parallel optical-signal processing and multi-channel optical recording are discussed. Researchers and graduate students in solid state physics and electrical engineering studying the properties and applications of such arrays will find this book invaluable.

  7. Microfabricated ion trap array

    Science.gov (United States)

    Blain, Matthew G.; Fleming, James G.

    2006-12-26

    A microfabricated ion trap array, comprising a plurality of ion traps having an inner radius of order one micron, can be fabricated using surface micromachining techniques and materials known to the integrated circuits manufacturing and microelectromechanical systems industries. Micromachining methods enable batch fabrication, reduced manufacturing costs, dimensional and positional precision, and monolithic integration of massive arrays of ion traps with microscale ion generation and detection devices. Massive arraying enables the microscale ion traps to retain the resolution, sensitivity, and mass range advantages necessary for high chemical selectivity. The reduced electrode voltage enables integration of the microfabricated ion trap array with on-chip circuit-based rf operation and detection electronics (i.e., cell phone electronics). Therefore, the full performance advantages of the microfabricated ion trap array can be realized in truly field portable, handheld microanalysis systems.

  8. A Quantitative Tool for Producing DNA-Based Diagnostic Arrays

    Energy Technology Data Exchange (ETDEWEB)

    Tom J. Whitaker

    2008-07-11

    The purpose of this project was to develop a precise, quantitative method to analyze oligodeoxynucleotides (ODNs) on an array to enable a systematic approach to quality control issues affecting DNA microarrays. Two types of ODN's were tested; ODN's formed by photolithography and ODN's printed onto microarrays. Initial work in Phase I, performed in conjunction with Affymetrix, Inc. who has a patent on a photolithographic in situ technique for creating DNA arrays, was very promising but did seem to indicate that the atomization process was not complete. Soon after Phase II work was under way, Affymetrix had further developed fluorescent methods and indicated they were no longer interested in our resonance ionization technique. This was communicated to the program manager and it was decided that the project would continue and be focused on printed ODNs. The method being tested is called SIRIS, Sputter-Initiated Resonance Ionization Spectroscopy. SIRIS has been shown to be a highly sensitive, selective, and quantitative tool for atomic species. This project was aimed at determining if an ODN could be labeled in such a way that SIRIS could be used to measure the label and thus provide quantitative measurements of the ODN on an array. One of the largest problems in this study has been developing a method that allows us to know the amount of an ODN on a surface independent of the SIRIS measurement. Even though we could accurately determine the amount of ODN deposited on a surface, the amount that actually attached to the surface is very difficult to measure (hence the need for a quantitative tool). A double-labeling procedure was developed in which 33P and Pt were both used to label ODNs. The radioactive 33P could be measured by a proportional counter that maps the counts in one dimension. This gave a good measurement of the amount of ODN remaining on a surface after immobilization and washing. A second label, Pt, was attached to guanine nucleotides in the

  9. Expanding maps, shrinking targets and hitting times

    International Nuclear Information System (INIS)

    We study the (metric) Diophantine approximation properties of uniformly expanding transformations and some non-uniformly expanding transformations, i.e. transformations T(x) with an associated countable (not necessarily finite) partition and a return time function R(x) (constant on the blocks of the partition) so that T-circumflex(x)=TR(x)(x) is uniformly expanding, and we obtain Borel–Cantelli results on hitting times of shrinking targets. Our arguments do not require the so-called big image property for T-circumflex and our results contain most of the diversity of examples of slowly mixing systems. We also obtain, with related techniques, results for one-sided topological Markov chains over a countable alphabet with a Gibbs measure. (paper)

  10. Strong shock in the uniformly expanding medium

    CERN Document Server

    Bisnovatyi-Kogan, G S

    2014-01-01

    Propagation of the strong shock in the flat expanding Friedman universe is investigated using methods of dimension and similarity. Exact analytic solution of self-similar equations is obtained, determining dependences of the radius and velocity of the shock wave on time and radius. It is obtained, that in the expanding medium the velocity of shock decreases as $\\sim t^{-1/5}$, what is slower than the shock velocity in the static uniform medium $\\sim t^{-3/5}$. The radius of the shock wave in the expanding self-gravitating medium increases $\\sim t^{4/5}$, more rapidly than the shock wave radius in the uniform non-gravitating medium $\\sim t^{2/5}$. So, the shock propagates in the direction of decreasing density with larger speed, that in the static medium, due to accelerating action of the decreasing density, even in the presence of a self-gravitation.

  11. Introduction to adaptive arrays

    CERN Document Server

    Monzingo, Bob; Haupt, Randy

    2011-01-01

    This second edition is an extensive modernization of the bestselling introduction to the subject of adaptive array sensor systems. With the number of applications of adaptive array sensor systems growing each year, this look at the principles and fundamental techniques that are critical to these systems is more important than ever before. Introduction to Adaptive Arrays, 2nd Edition is organized as a tutorial, taking the reader by the hand and leading them through the maze of jargon that often surrounds this highly technical subject. It is easy to read and easy to follow as fundamental concept

  12. Akeno 20 km (2) air shower array (Akeno Branch)

    Science.gov (United States)

    Teshima, M.; Ohoka, H.; Matsubara, Y.; Hara, T.; Hatano, Y.; Hayashida, N.; He, C. X.; Honda, M.; Ishikawa, F.; Kamata, K.

    1985-01-01

    As the first stage of the future huge array, the Akeno air shower array was expanded to about 20 sq. km. by adding 19 scintillation detectors of 2.25 sq m area outside the present 1 sq. km. Akeno array with a new data collection system. These detectors are spaced about 1km from each other and connected by two optical fiber cables. This array has been in partial operation from 8th, Sep. 1984 and full operation from 20th, Dec. 1984. 20 sq m muon stations are planned to be set with 2km separation and one of them is now under construction. The origin of the highest energy cosmic rays is studied.

  13. High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors: Four cases of homozygous deletions of the CDKN2A gene

    Directory of Open Access Journals (Sweden)

    Kogner Per

    2008-07-01

    Full Text Available Abstract Background Neuroblastoma is a very heterogeneous pediatric tumor of the sympathetic nervous system showing clinically significant patterns of genetic alterations. Favorable tumors usually have near-triploid karyotypes with few structural rearrangements. Aggressive stage 4 tumors often have near-diploid or near-tetraploid karyotypes and structural rearrangements. Whole genome approaches for analysis of genome-wide copy number have been used to analyze chromosomal abnormalities in tumor samples. We have used array-based copy number analysis using oligonucleotide single nucleotide polymorphisms (SNP arrays to analyze the chromosomal structure of a large number of neuroblastoma tumors of different clinical and biological subsets. Results Ninety-two neuroblastoma tumors were analyzed with 50 K and/or 250 K SNP arrays from Affymetrix, using CNAG3.0 software. Thirty percent of the tumors harbored 1p deletion, 22% deletion of 11q, 26% had MYCN amplification and 45% 17q gain. Most of the tumors with 1p deletion were found among those with MYCN amplification. Loss of 11q was most commonly seen in tumors without MYCN amplification. In the case of MYCN amplification, two types were identified. One type displayed simple continuous amplicons; the other type harbored more complex rearrangements. MYCN was the only common gene in all cases with amplification. Complex amplification on chromosome 12 was detected in two tumors and three different overlapping regions of amplification were identified. Two regions with homozygous deletions, four cases with CDKN2A deletions in 9p and one case with deletion on 3p (the gene RBMS3 were also detected in the tumors. Conclusion SNP arrays provide useful tools for high-resolution characterization of significant chromosomal rearrangements in neuroblastoma tumors. The mapping arrays from Affymetrix provide both copy number and allele-specific information at a resolution of 10–12 kb. Chromosome 9p, especially the gene

  14. Protein Functionalized Nanodiamond Arrays

    Directory of Open Access Journals (Sweden)

    Liu YL

    2010-01-01

    Full Text Available Abstract Various nanoscale elements are currently being explored for bio-applications, such as in bio-images, bio-detection, and bio-sensors. Among them, nanodiamonds possess remarkable features such as low bio-cytotoxicity, good optical property in fluorescent and Raman spectra, and good photostability for bio-applications. In this work, we devise techniques to position functionalized nanodiamonds on self-assembled monolayer (SAMs arrays adsorbed on silicon and ITO substrates surface using electron beam lithography techniques. The nanodiamond arrays were functionalized with lysozyme to target a certain biomolecule or protein specifically. The optical properties of the nanodiamond-protein complex arrays were characterized by a high throughput confocal microscope. The synthesized nanodiamond-lysozyme complex arrays were found to still retain their functionality in interacting with E. coli.

  15. Permutations of cubical arrays

    International Nuclear Information System (INIS)

    The structure constants of an algebra determine a cube called the cubical array associated with the algebra. The permuted indices of the cubical array associated with a finite semifield generate new division algebras. We do not not require that the algebra be finite and ask 'Is it possible to choose a basis for the algebra such any permutation of the indices of the structure constants leaves the algebra unchanged?' What are the associated algebras? Author shows that the property 'weakly quadratic' is invariant under all permutations of the indices of the corresponding cubical array and presents two algebras for which the cubical array is invariant under all permutations of the indices.

  16. Flexible retinal electrode array

    Energy Technology Data Exchange (ETDEWEB)

    Okandan, Murat (Albuquerque, NM); Wessendorf, Kurt O. (Albuquerque, NM); Christenson, Todd R. (Albuquerque, NM)

    2006-10-24

    An electrode array which has applications for neural stimulation and sensing. The electrode array can include a large number of electrodes each of which is flexibly attached to a common substrate using a plurality of springs to allow the electrodes to move independently. The electrode array can be formed from a combination of bulk and surface micromachining, with electrode tips that can include an electroplated metal (e.g. platinum, iridium, gold or titanium) or a metal oxide (e.g. iridium oxide) for biocompatibility. The electrode array can be used to form a part of a neural prosthesis, and is particularly well adapted for use in an implantable retinal prosthesis where the electrodes can be tailored to provide a uniform gentle contact pressure with optional sensing of this contact pressure at one or more of the electrodes.

  17. Responsible implementation of expanded carrier screening.

    Science.gov (United States)

    Henneman, Lidewij; Borry, Pascal; Chokoshvili, Davit; Cornel, Martina C; van El, Carla G; Forzano, Francesca; Hall, Alison; Howard, Heidi C; Janssens, Sandra; Kayserili, Hülya; Lakeman, Phillis; Lucassen, Anneke; Metcalfe, Sylvia A; Vidmar, Lovro; de Wert, Guido; Dondorp, Wybo J; Peterlin, Borut

    2016-06-01

    This document of the European Society of Human Genetics contains recommendations regarding responsible implementation of expanded carrier screening. Carrier screening is defined here as the detection of carrier status of recessive diseases in couples or persons who do not have an a priori increased risk of being a carrier based on their or their partners' personal or family history. Expanded carrier screening offers carrier screening for multiple autosomal and X-linked recessive disorders, facilitated by new genetic testing technologies, and allows testing of individuals regardless of ancestry or geographic origin. Carrier screening aims to identify couples who have an increased risk of having an affected child in order to facilitate informed reproductive decision making. In previous decades, carrier screening was typically performed for one or few relatively common recessive disorders associated with significant morbidity, reduced life-expectancy and often because of a considerable higher carrier frequency in a specific population for certain diseases. New genetic testing technologies enable the expansion of screening to multiple conditions, genes or sequence variants. Expanded carrier screening panels that have been introduced to date have been advertised and offered to health care professionals and the public on a commercial basis. This document discusses the challenges that expanded carrier screening might pose in the context of the lessons learnt from decades of population-based carrier screening and in the context of existing screening criteria. It aims to contribute to the public and professional discussion and to arrive at better clinical and laboratory practice guidelines. PMID:26980105

  18. Local symmetries of non-expanding horizons

    International Nuclear Information System (INIS)

    Local symmetries of a non-expanding horizon have been investigated in the first-order formulation of gravity. When applied to spherically symmetric horizons, only a U(1) subgroup of the Lorentz group survives as a residual local symmetry that one can make use of in constructing an effective theory on the horizon. (paper)

  19. Symmetry reduction on non-expanding horizons

    International Nuclear Information System (INIS)

    Local symmetries of a non-expanding horizon have been investigated in the 1st order formulation of gravity. When applied to a spherically symmetric horizons, only a U(1) subgroup of the Lorentz group survives as residual local symmetry that one can make use of in constructing an effective theory on the horizon

  20. Expanding CTE Opportunities through Blended Learning

    Science.gov (United States)

    McKinstry, Elizabeth

    2012-01-01

    The global economy, 21st century skills, knowledge society, college and career readiness, digital and project-based learning are all common terms to educators who are expanding their learning environments beyond the classroom to meet the needs of all students. It is common knowledge that the rapid technological advances of this century have…

  1. Expanding clinical spectrum and broadening therapeutic horizons

    OpenAIRE

    Ombrello, Michael J.; Kastner, Daniel L.

    2011-01-01

    In 2010, important research into the systemic autoinflammatory diseases has confirmed and extended the role of IL-1 inhibition in hereditary autoinflammatory disorders, demonstrated a novel treatment for a dangerous complication, and expanded the spectrum of systemic autoinflammatory diseases while further implicating autoinflammation in the pathophysiology of the metabolic syndrome.

  2. Expanding the applicability of Heallth Technology Assessments

    DEFF Research Database (Denmark)

    Draborg, Eva; Hansen, Helle Ploug

    2012-01-01

    The objective of the presentation is to expand the foundations of input into policy decision making relying on health technology assessments (HTA). HTAs are primarily based on systematic reviews (SR) and thereby mostly on randomized controlled trials (RCT). RCTs can be distinguished on a continuu...

  3. Descending entropy in expanding the universe

    Science.gov (United States)

    Portnov, Yuriy A.

    2015-11-01

    Inter-relation between 1-form of nonmetricity and change of entropy in the course of time is considered in the study. It is shown that change of entropy in expanding universe will be always negative. The obtained result contravenes the second law of thermodynamics, however it explains available ordered macrostructures in the universe.

  4. Expanding Your Horizons Conference in Geneva

    CERN Multimedia

    Chromek-Burckhart, Doris

    2011-01-01

    CERN and its experiments participated in Expanding Your Horizons (EYH) in Science and Mathematics conference in Geneva on 12th November. EYH nurture girls' interest in science and math courses to encourage them to consider careers in science, technology, engineering, and math.

  5. Expanded austenite, crystallography and residual stress

    DEFF Research Database (Denmark)

    Christiansen, Thomas; Hummelshøj, Thomas Strabo; Somers, Marcel A. J.

    2010-01-01

    The identity of expanded austenite as developing during low temperature nitriding and/or carburising of austenitic stainless steel has been under debate since the very first observation of this phase. In the present article, recent results obtained with (a) homogeneous samples of various uniform ...

  6. Expanded austenite; crystallography and residual stress

    DEFF Research Database (Denmark)

    Christiansen, Thomas; Hummelshøj, Thomas Strabo; Somers, Marcel A. J.

    2009-01-01

    The identity of expanded austenite as developing during low temperature nitriding and/or carburizing of austenitic stainless steel has been under debate since the very first observation of this phase. In the present article recent results obtained with i) homogeneous samples of various uniform co...

  7. Expanded austenite; crystallography and residual stress

    DEFF Research Database (Denmark)

    Christiansen, Thomas; Hummelshøj, Thomas Strabo; Somers, Marcel A. J.

    The identity of expanded austenite as developing during low temperature nitriding and/or carburizing of austenitic stainless steel has been under debate since the very first observation of this phase. In the present article recent results obtained with i) homogeneous samples of various uniform co...

  8. Aligators for arrays

    OpenAIRE

    Henzinger, Thomas A.; Hottelier, Thibaud; Kovács, Laura; Rybalchenko, Andrey

    2010-01-01

    This paper presents Aligators, a tool for the generation of universally quantified array invariants. Aligators leverages recurrence solving and algebraic techniques to carry out inductive reasoning over array content. The Aligators’ loop extraction module allows treatment of multi-path loops by exploiting their commutativity and serializability properties. Our experience in applying Aligators on a collection of loops from open source software projects indicates the applicability of recurren...

  9. RFID array sensing

    OpenAIRE

    Capdevila Cascante, Santiago; Jofre Roca, Lluís; Romeu Robert, Jordi; Bolomey, J.Ch

    2010-01-01

    In this paper the use of RFID tags for the measurement of physical parameters in a distributed set of points is presented. Experimental results for two different scenarios are presented; the first uses a 2D RFID array to measure the field distribution of a radiating aperture, while the second detects the change in the close environment of an array of RFID tags to determine the water level of a container.

  10. Microphone arrays fundamentals

    OpenAIRE

    Embrechts, Jean-Jacques

    2011-01-01

    Microphone arrays are essentially directional sensors. They are therefore mainly used for locating, identifying, isolating, measuring and recording individual sound sources. The main principles governing the directivity of microphone arrays are reviewed: phase differences between signals create constructive and destructive interferences, depending on the direction of the sound source. Moreover, signal processing is applied to provide “beamforming”, i.e. beam shaping and steering. Contrary to ...

  11. Genome-wide analysis of neuroblastomas using high-density single nucleotide polymorphism arrays.

    Directory of Open Access Journals (Sweden)

    Rani E George

    Full Text Available BACKGROUND: Neuroblastomas are characterized by chromosomal alterations with biological and clinical significance. We analyzed paired blood and primary tumor samples from 22 children with high-risk neuroblastoma for loss of heterozygosity (LOH and DNA copy number change using the Affymetrix 10K single nucleotide polymorphism (SNP array. FINDINGS: Multiple areas of LOH and copy number gain were seen. The most commonly observed area of LOH was on chromosome arm 11q (15/22 samples; 68%. Chromosome 11q LOH was highly associated with occurrence of chromosome 3p LOH: 9 of the 15 samples with 11q LOH had concomitant 3p LOH (P = 0.016. Chromosome 1p LOH was seen in one-third of cases. LOH events on chromosomes 11q and 1p were generally accompanied by copy number loss, indicating hemizygous deletion within these regions. The one exception was on chromosome 11p, where LOH in all four cases was accompanied by normal copy number or diploidy, implying uniparental disomy. Gain of copy number was most frequently observed on chromosome arm 17q (21/22 samples; 95% and was associated with allelic imbalance in six samples. Amplification of MYCN was also noted, and also amplification of a second gene, ALK, in a single case. CONCLUSIONS: This analysis demonstrates the power of SNP arrays for high-resolution determination of LOH and DNA copy number change in neuroblastoma, a tumor in which specific allelic changes drive clinical outcome and selection of therapy.

  12. Refrigeration generation using expander-generator units

    Science.gov (United States)

    Klimenko, A. V.; Agababov, V. S.; Koryagin, A. V.; Baidakova, Yu. O.

    2016-05-01

    The problems of using the expander-generator unit (EGU) to generate refrigeration, along with electricity were considered. It is shown that, on the level of the temperatures of refrigeration flows using the EGU, one can provide the refrigeration supply of the different consumers: ventilation and air conditioning plants and industrial refrigerators and freezers. The analysis of influence of process parameters on the cooling power of the EGU, which depends on the parameters of the gas expansion process in the expander and temperatures of cooled environment, was carried out. The schematic diagram of refrigeration generation plant based on EGU is presented. The features and advantages of EGU to generate refrigeration compared with thermotransformer of steam compressive and absorption types were shown, namely: there is no need to use the energy generated by burning fuel to operate the EGU; beneficial use of the heat delivered to gas from the flow being cooled in equipment operating on gas; energy production along with refrigeration generation, which makes it possible to create, using EGU, the trigeneration plants without using the energy power equipment. It is shown that the level of the temperatures of refrigeration flows, which can be obtained by using the EGU on existing technological decompression stations of the transported gas, allows providing the refrigeration supply of various consumers. The information that the refrigeration capacity of an expander-generator unit not only depends on the parameters of the process of expansion of gas flowing in the expander (flow rate, temperatures and pressures at the inlet and outlet) but it is also determined by the temperature needed for a consumer and the initial temperature of the flow of the refrigeration-carrier being cooled. The conclusion was made that the expander-generator units can be used to create trigeneration plants both at major power plants and at small energy.

  13. Solution-Liquid-Solid Synthesis of Hexagonal Nickel Selenide Nanowire Arrays with a Nonmetal Catalyst.

    Science.gov (United States)

    Xu, Kun; Ding, Hui; Jia, Kaicheng; Lu, Xiuli; Chen, Pengzuo; Zhou, Tianpei; Cheng, Han; Liu, Si; Wu, Changzheng; Xie, Yi

    2016-01-26

    Inorganic nanowire arrays hold great promise for next-generation energy storage and conversion devices. Understanding the growth mechanism of nanowire arrays is of considerable interest for expanding the range of applications. Herein, we report the solution-liquid-solid (SLS) synthesis of hexagonal nickel selenide nanowires by using a nonmetal molecular crystal (selenium) as catalyst, which successfully brings SLS into the realm of conventional low-temperature solution synthesis. As a proof-of-concept application, the NiSe nanowire array was used as a catalyst for electrochemical water oxidation. This approach offers a new possibility to design arrays of inorganic nanowires. PMID:26695560

  14. A new alternative to expandable pedicle screws: Expandable poly-ether-ether-ketone shell.

    Science.gov (United States)

    Demir, Teyfik

    2015-05-01

    Screw pullout is a very common problem in the fixation of sacrum with pedicle screws. The principal cause of this problem is that the cyclic micro motions in the fixation of sacrum are higher than the other regions of the vertebrae that limit the osteo-integration between bone and screw. In addition to that, the bone quality is very poor at sacrum region. This study investigated a possible solution to the pullout problem without the expandable screws' handicaps. Newly designed poly-ether-ether-ketone expandable shell and classical pedicle screws were biomechanically compared. Torsion test, pullout tests, fatigue tests, flexion/extension moment test, axial gripping capacity tests and torsional gripping capacity tests were conducted in accordance with ASTM F543, F1798 and F1717. Standard polyurethane foam and calf vertebrae were used as embedding medium for pullout tests. Classical pedicle screw pullout load on polyurethane foam was 564.8 N compared to the failure load for calf vertebrae's 1264 N. Under the same test conditions, expandable poly-ether-ether-ketone shell system's pullout loads from polyurethane foam and calf vertebrae were 1196.3 and 1890 N, respectively. The pullout values for expandable poly-ether-ether-ketone shell were 33% and 53% higher than classical pedicle screw on polyurethane foam and calf vertebrae, respectively. The expandable poly-ether-ether-ketone shell exhibited endurance on its 90% of yield load. Contrary to poly-ether-ether-ketone shell, classical pedicle screw exhibited endurance on 70% of its yield load. Expandable poly-ether-ether-ketone shell exhibited much higher pullout performance than classical pedicle screw. Fatigue performance of expandable poly-ether-ether-ketone shell is also higher than classical pedicle screw due to damping the micro motion capacity of the poly-ether-ether-ketone. Expandable poly-ether-ether-ketone shell is a safe alternative to all other expandable pedicle screw systems on mechanical perspective

  15. Implementation of exon arrays: alternative splicing during T-cell proliferation as determined by whole genome analysis

    Directory of Open Access Journals (Sweden)

    Whistler Toni

    2010-09-01

    Full Text Available Abstract Background The contribution of alternative splicing and isoform expression to cellular response is emerging as an area of considerable interest, and the newly developed exon arrays allow for systematic study of these processes. We use this pilot study to report on the feasibility of exon array implementation looking to replace the 3' in vitro transcription expression arrays in our laboratory. One of the most widely studied models of cellular response is T-cell activation from exogenous stimulation. Microarray studies have contributed to our understanding of key pathways activated during T-cell stimulation. We use this system to examine whole genome transcription and alternate exon usage events that are regulated during lymphocyte proliferation in an attempt to evaluate the exon arrays. Results Peripheral blood mononuclear cells form healthy donors were activated using phytohemagglutinin, IL2 and ionomycin and harvested at 5 points over a 7 day period. Flow cytometry measured cell cycle events and the Affymetrix exon array platform was used to identify the gene expression and alternate exon usage changes. Gene expression changes were noted in a total of 2105 transcripts, and alternate exon usage identified in 472 transcript clusters. There was an overlap of 263 transcripts which showed both differential expression and alternate exon usage over time. Gene ontology enrichment analysis showed a broader range of biological changes in biological processes for the differentially expressed genes, which include cell cycle, cell division, cell proliferation, chromosome segregation, cell death, component organization and biogenesis and metabolic process ontologies. The alternate exon usage ontological enrichments are in metabolism and component organization and biogenesis. We focus on alternate exon usage changes in the transcripts of the spliceosome complex. The real-time PCR validation rates were 86% for transcript expression and 71% for

  16. Optimizing Chemical Sensor Array Sizes

    International Nuclear Information System (INIS)

    Optimal selection of array sensors for a chemical sensing application is a nontrivial task. It is commonly believed that ''more is better'' when choosing the number of sensors required to achieve good chemical selectivity. However, cost and system complexity issues point towards the choice of small arrays. A quantitative array optimization is carried out to explore the selectivity of arrays of partially-selective chemical sensors as a function of array size. It is shown that modest numbers (dozens) of target analytes are completely distinguished with a range of arrays sizes. However, the array selectivity and the robustness against sensor sensitivity variability are significantly degraded if the array size is increased above a certain number of sensors, so that relatively small arrays provide the best performance. The results also suggest that data analyses for very large arrays of partially-selective sensors will be optimized by separately anal yzing small sensor subsets

  17. Carbohydrate plasma expanders for passive tumor targeting

    DEFF Research Database (Denmark)

    Hoffmann, Stefan; Caysa, Henrike; Kuntsche, Judith;

    2013-01-01

    The objective of this study was to investigate the suitability of carbohydrate plasma volume expanders as a novel polymer platform for tumor targeting. Many synthetic polymers have already been synthesized for targeted tumor therapy, but potential advantages of these carbohydrates include...... inexpensive synthesis, constant availability, a good safety profile, biodegradability and the long clinical use as plasma expanders. Three polymers have been tested for cytotoxicity and cytokine activation in cell cultures and conjugated with a near-infrared fluorescent dye: hydroxyethyl starches (HES 200 k......Da and HES 450 kDa) and dextran (DEX 500 kDa). Particle size and molecular weight distribution were determined by asymmetric flow field-flow fractionation (AF4). The biodistribution was investigated non-invasively in nude mice using multispectral optical imaging. The most promising polymer conjugate was...

  18. Demands of Expanding Populations and Development Planning

    Science.gov (United States)

    Lim, Bo

    2010-04-01

    This book is a practical resource for development planners, demographers, and organizations involved with development projects related to improving the well-being and welfare of expanding human populations. Demands of Expanding Populations and Development Planning essentially is a treatment on sustainability and includes a heavy emphasis on major issues of environmental pollution over the last 3 decades. The book's coverage of ecosystems, atmospheric chemistry, water availability and quality, and soils is comprehensive. The author's extensive teaching experience makes this somewhat of an authoritative book on air quality and emissions from natural and anthropogenic sources, volatile heavy metals, carbon monoxide, radon, and nuclear waste. Most of the book focuses on the atmospheric chemistry of air pollution, whether the pollution source is from energy, industrial production, and manufacturing processes or from the treatment of waste products from such processes.

  19. Transformative Creativity in the Expanded Digital Field

    DEFF Research Database (Denmark)

    Søndergaard, Morten

    , focusing on existence transcending time and space, and the creation of the radical ‘new’. The question is: does transformative creativity today add something new? Is participatory practices brought on by digital technologies inside or outside the complex of modernity? By analyzing examples from new art...... field, which I will call the expanded digital field. The expanded digital field encompasses transformation of societal, cultural, political and individual creativity on three levels (my hypothesis): Technologies become reactive, hence reproduction of creativity becomes the standard for communication......The idea that art may (can/will) transform ‘society’ is not a new one. Some would call it idealism - or an ideology, even – to have anything outside the market create transformation. But changes over the last decade, in the cultural constitution of the world’s global culture and economy, have...

  20. Gravitational instability in a multicomponent expanding medium

    International Nuclear Information System (INIS)

    In the Newtonian approximation we consider the gravitational instability of a two- or N-component medium in an expanding universe. The system of density-perturbation equations is solved in the short- and long-wave limits. For small values of the wave vector k, a result obtained for the stationary case continues to hold true: at most there can exist only one unstable mode. If k is kept fixed, the introduction of a perturbation component delta/sub i/ will speed the growth of fluctuations delta/sub j/, provided the adiabatic indices γ/sub i/>γ/sub j/. In the large-k limit, ordinary acoustic waves result. Other components will begin to manifest themselves in the first-order terms when the oscillation amplitude is expanded in powers of k-1: provided γ/sub j/>γ/sub i/> or =4/3, the ith-component amplitude will decay more slowly than otherwise

  1. Imaging antenna arrays

    Science.gov (United States)

    Rutledge, D. B.; Muha, M. S.

    1982-01-01

    Many millimeter and far-infrared imaging systems are limited in sensitivity and speed because they depend on a single scanned element. Because of recent advances in planar detectors such as Schottky diodes, superconducting tunnel junctions, and microbolometers, an attractive approach to this problem is a planar antenna array with integrated detectors. A planar line antenna array and optical system for imaging has been developed. The significant advances are a 'reverse-microscope' optical configuration and a modified bow-tie antenna design. In the 'reverse-microscope' configuration, a lens is attached to the bottom of the substrate containing the antennas. Imaging is done through the substrate. This configuration eliminates the troublesome effects of substrate surface waves. The substrate lens has only a single refracting surface, making possible a virtually aplanatic system, with little spherical aberration or coma. The array is characterized by an optical transfer function that is easily measured. An array with 19 dB crosstalk levels between adjacent antennas has been tested and it was found that the array captured 50 percent of the available power. This imaging system was diffraction limited.

  2. Perspectives of Expanding Business into Russia

    OpenAIRE

    Samaeva, Naylya

    2014-01-01

    The purpose of the thesis was to analyze and evaluate the Russian market taking into account all its advantages and disadvantages and to find out whether it was profitable for the case company Hotel Vip Club International Oy to expand its business into Rus-sia. The study includes theoretical framework covering different essential theories and concepts, information about tourism and hotel related business in Russia, and the pecu-liarities of doing business in Russia including the analyses of t...

  3. GWDC Expands High-End Market Share

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ It is a decision of great significance for GWDC to expand high-end market share in order to realize its transformation of development strategy and improve its development quality. As an important step of GWDC to explore high-end market, Oman PDO Project marks the first time that the Chinese petroleum engineering service team cooperates with the transnational petroleum corporations ranking first three in the world.

  4. Inextendibility of expanding cosmological models with symmetry

    Energy Technology Data Exchange (ETDEWEB)

    Dafermos, Mihalis [University of Cambridge, Department of Pure Mathematics and Mathematical Statistics, Wilberforce Road, Cambridge CB3 0WB (United Kingdom); Rendall, Alan D [Max Planck Institute for Gravitational Physics, Albert Einstein Institute, Am Muehlenberg 1, D-14476 Golm (Germany)

    2005-12-07

    A new criterion for inextendibility of expanding cosmological models with symmetry is presented. It is applied to derive a number of new results and to simplify the proofs of existing ones. In particular, it shows that the solutions of the Einstein-Vlasov system with T{sup 2} symmetry, including the vacuum solutions, are inextendible in the future. The technique introduced adds a qualitatively new element to the available tool-kit for studying strong cosmic censorship. (letter to the editor)

  5. The Expanding Universe of Prion Diseases

    OpenAIRE

    Watts, Joel C.; Aru Balachandran; David Westaway

    2006-01-01

    Prions cause fatal and transmissible neurodegenerative disease. These etiological infectious agents are formed in greater part from a misfolded cell-surface protein called PrP(C). Several mammalian species are affected by the diseases, and in the case of "mad cow disease" (BSE) the agent has a tropism for humans, with negative consequences for agribusiness and public health. Unfortunately, the known universe of prion diseases is expanding. At least four novel prion diseases--including human d...

  6. Short wavelength striations on expanding plasma clouds

    International Nuclear Information System (INIS)

    The growth and evolution of short wavelength (< ion gyroradius) flute modes on a plasma expanding across an ambient magnetic field have been actively studied in recent years, both by means of experiments in the laboratory as well as in space and through numerical simulations. We review the relevant observations and simulations results, discuss the instability mechanism and related linear theory, and describe recent work to bring experiments and theory into better agreement. 30 refs., 6 figs

  7. Femoral midshaft fractures: expandable versus locked nailing.

    Science.gov (United States)

    Zhou, Zhen-Tao; Song, Yu-Chen; Zhou, Xiao-Zhong; Zhou, Hai-Bin; Luo, Zong-Ping; Dong, Qi-Rong

    2015-04-01

    Femoral midshaft fracture is one of the most common clinical injuries and is often caused by high-energy traffic accidents. Intramedullary nailings, plates, and external fixators are all used as treatment alternatives for a variety of patients depending on fracture location, displacement, comminution, soft tissue condition, and local tradition. Locked intramedullary nailing is currently the preferred treatment method for most diaphyseal fractures and has good clinical results. The goal of this study was to compare expandable and locked intramedullary nailing for the treatment of AO type 32A and 32B1 femoral midshaft fractures. The authors performed a retrospective analysis of 46 patients (33 men and 13 women; mean age, 32.3 years; range, 22-52 years) with femoral midshaft fractures who were divided into 2 groups-one treated with an expandable intramedullary nailing method and the other with a conventional locked intramedullary nailing. The 2 groups were compared with respect to operation time, fluoroscopic time, amount of estimated blood loss, hospitalization time, healing time, and complications. Patients were followed for at least 1 year. The results of this study showed that all of the patients achieved bone union within 12 to 24 months. Expandable nailing performed better than locked nailing in operation time, fluoroscopic time, amount of estimated blood loss, and healing time (P<.001). There was no difference in hospitalization time and no visible shortening or severe complications were observed in either group. Based on the results of this study, the expandable intramedullary nailing is an easy and effective treatment for AO type 32A and 32B1 diaphyseal femoral fractures. PMID:25901625

  8. Hubble, Hubble's law and the expanding universe

    CERN Document Server

    Bagla, J S

    2009-01-01

    Hubble's name is associated closely with the idea of an expanding universe as he discovered the relation between the recession velocity and distances of galaxies. Hubble also did a lot of pioneering work on the distribution of galaxies in the universe. In this article we take a look at Hubble's law and discuss how it relates with models of the universe. We also give a historical perspective of the discoveries that led to the Hubble's law.

  9. Vector bosons in the expanding universe

    International Nuclear Information System (INIS)

    We exactly solve the relativistic wave equation for vector bosons in the expanding universe and show that the current of the vector bosons in this background is rapidly oscillating in early time. Additionally, we derive the solutions of the Proca equation from the solutions of the Duffin-Kemmer-Petiau (DKP) equations in the same background and obtain the massless-particle, photon, solutions by taking the m2→0 limit of these solutions. (orig.)

  10. Optical cavity resonator in an expanding universe

    CERN Document Server

    Kopeikin, Sergei

    2014-01-01

    We study evolution of frequency of a standing electromagnetic (EM) wave in a resonant optical cavity placed to the expanding manifold described by the Robertson-Walker metric. One builds a local coordinate system in which spacetime is locally Minkowskian. However, due to the conformal nature of the Robertson-Walker metric the conventional transformation to the local inertial coordinates introduces ambiguity in the physical interpretation of the local time coordinate. Therefore, contrary to a common-sense expectation, a straightforward implementation of EEP alone does not allow us to decide whether atomic clocks ticks at the same rate as the clocks based on EM modes of a cavity. To resolve the ambiguity we analyzed the cavity rigidity and the oscillation of its EM modes in an expanding universe by employing the Maxwell equations. We found out that both the size of the cavity and the EM frequency experience an adiabatic drift in conformal coordinates as the universe expands. We set up the oscillation equation f...

  11. Inverted porphyrins and expanded porphyrins: An overview

    Indian Academy of Sciences (India)

    S K Pushpan; S Venkatraman; V G Anand; J Sankar; H Rath; T K Chandrashekar

    2002-08-01

    Porphyrins and metallopophyrins have attracted the attention of chemists for the past 100 years or more owing to their widespread involvement in biology. More recently, synthetic porphyrins and porphyrin-like macrocycles have attracted the attention of researchers due to their diverse applications as sensitizers for photodynamic therapy, MRI contrasting agents, and complexing agents for larger metal ions and also for their anion binding abilities. The number of -electrons in the porphyrin ring can be increased either by increasing the number of conjugated double bonds between the pyrrole rings or by increasing the number of heterocyclic rings. Thus, 22 sapphyrins, 26 rubyrins, 30 heptaphyrins, 34 octaphyrins and higher cyclic polypyrrole analogues containing 40, 48, 64, 80 and 96 systems have recently been reported in the literature. These macrocycles show rich structural diversity where normal and different kinds of inverted structures have been identified. In this review, an attempt has been made to collect the literature of the inverted porphyrins and expanded porphyrins reported until December 2001. Since the meso aryl expanded porphyrins have tendency to form both inverted and non-inverted structures more emphasis has been given to meso aryl expanded porphyrins.

  12. Characterization of commercial expandable graphite fire retardants

    International Nuclear Information System (INIS)

    Highlights: • Expandable graphite is less well-ordered than its graphite bisulfate progenitor. • It includes graphite oxide as a randomly interstratified phase. • CO2, CO and SO2 are released during thermal-driven exfoliation. - Abstract: Thermal analysis and other techniques were employed to characterize two expandable graphite samples. The expansion onset temperatures of the expandable graphite's were ca. 220 °C and 300 °C respectively. The key finding is that the commercial products are not just pure graphite intercalation compounds with sulfuric acid species intercalated as guest ions and molecules in between intact graphene layers. A more realistic model is proposed where graphite oxide-like layers are also randomly interstratified in the graphite flakes. These graphite oxide-like layers comprise highly oxidized graphene sheets which contain many different oxygen-containing functional groups. This model explains the high oxygen to sulfur atomic ratios found in both elemental analysis of the neat materials and in the gas generated during the main exfoliation event

  13. Tissue Expander versus Tissue Expander and Latissimus Flap in Morbidly Obese Breast Reconstruction Patients

    Science.gov (United States)

    Adams, Robert L.; Chandler, Robert G.; Parks, Joseph

    2015-01-01

    Background: Immediate postmastectomy breast reconstruction in morbidly obese patients represents a challenge because neither prosthetic nor abdominal-based options may be suitable. Methods: This study compared a previously published cohort of immediate prosthetic reconstruction of 346 patients (511 breasts) of whom 49 patients (67 breasts) were morbidly obese (defined as a body mass index > 35) with a morbidly obese patient population whose breasts were reconstructed immediately following postmastectomy with latissimus flap and tissue expander (21 patients and 22 breasts) in the same time period. The preoperative risk factors of mastectomy such as tobacco use, diabetes, and prior radiation and the postoperative complications of mastectomy such as skin necrosis, seroma, and prosthesis loss were examined. The explantation of the tissue expander provided a defined endpoint of reconstruction failure. Results: The average body mass index in the tissue expander/implant group and in the latissimus flap plus tissue expander/implant group was 40.9 and 40.1, respectively. The risk profile of diabetes and tobacco use was similar in both groups. Fifteen of the 67 breasts (22.3%) of the tissue expander/implant group and 15 of the 23 breasts (65.2%) of the latissimus flap group had received prior radiation. The prosthesis loss was 13 of 67 breasts (19.4%) that had tissue-expander–alone reconstruction and 1 of 22 (4.8%) in the latissimus group that had tissue expander reconstruction. Modification of donor-site incision and skin-island location in the latissimus group of patients can minimize scar deformity. Conclusion: The loss rate in immediate postmastectomy reconstruction in morbidly obese patients with latissimus flap plus tissue expander was substantially lower than the loss rate in those with breast reconstructed with tissue expander alone. PMID:25878934

  14. FEL phased array configurations

    Science.gov (United States)

    Shellan, Jeffrey B.

    1986-01-01

    The advantages and disadvantages of various phased array and shared aperture concepts for FEL configurations are discussed. Consideration is given to the characteristics of intra- and inter-micropulse phasing; intra-macropulse phasing; an internal coupled resonator configuration; and an injection locked oscillator array. The use of a master oscillator power amplifier (MOPA) configuration with multiple or single master oscillators for FELs is examined. The venetian blind, rotating plate, single grating, and grating rhomb shared aperture concepts are analyzed. It is noted that the shared aperture approach using a grating rhomb and the MOPA concept with a single master oscillator and a coupled resonator are useful for FEL phased array configurations; and the MOPA concept is most applicable.

  15. Atacama Compact Array Antennas

    OpenAIRE

    Saito, Masao; Inatani, Junji; Nakanishi, Kouichiro; Naoi, Takahiro; Yamada, Masumi; Saito, Hiro; Ikenoue, Bungo; Kato, Yoshihiro; Morita, Kou-ichiro; Mizuno, Norikazu; Iguchi, Satoru

    2011-01-01

    We report major performance test results of the Atacama Compact Array (ACA) 7-m and 12-m antennas of ALMA (Atacama Large Millimeter/submillimeter Array). The four major performances of the ACA antennas are all-sky pointing (to be not more than 2.0 arcsec), offset pointing (to be < 0.6 arcsec) surface accuracy (< 25(20) micrometer for 12(7)m-antenna), stability of path-length (15 micrometer over 3 min), and high servo capability (6 degrees/s for Azimuth and 3 degrees/s for Elevation). The high...

  16. Wire Array Photovoltaics

    Science.gov (United States)

    Turner-Evans, Dan

    Over the past five years, the cost of solar panels has dropped drastically and, in concert, the number of installed modules has risen exponentially. However, solar electricity is still more than twice as expensive as electricity from a natural gas plant. Fortunately, wire array solar cells have emerged as a promising technology for further lowering the cost of solar. Si wire array solar cells are formed with a unique, low cost growth method and use 100 times less material than conventional Si cells. The wires can be embedded in a transparent, flexible polymer to create a free-standing array that can be rolled up for easy installation in a variety of form factors. Furthermore, by incorporating multijunctions into the wire morphology, higher efficiencies can be achieved while taking advantage of the unique defect relaxation pathways afforded by the 3D wire geometry. The work in this thesis shepherded Si wires from undoped arrays to flexible, functional large area devices and laid the groundwork for multijunction wire array cells. Fabrication techniques were developed to turn intrinsic Si wires into full p-n junctions and the wires were passivated with a-Si:H and a-SiNx:H. Single wire devices yielded open circuit voltages of 600 mV and efficiencies of 9%. The arrays were then embedded in a polymer and contacted with a transparent, flexible, Ni nanoparticle and Ag nanowire top contact. The contact connected >99% of the wires in parallel and yielded flexible, substrate free solar cells featuring hundreds of thousands of wires. Building on the success of the Si wire arrays, GaP was epitaxially grown on the material to create heterostructures for photoelectrochemistry. These cells were limited by low absorption in the GaP due to its indirect bandgap, and poor current collection due to a diffusion length of only 80 nm. However, GaAsP on SiGe offers a superior combination of materials, and wire architectures based on these semiconductors were investigated for multijunction

  17. A powerful method for detecting differentially expressed genes from GeneChip arrays that does not require replicates

    Directory of Open Access Journals (Sweden)

    Hein Anne-Mette K

    2006-07-01

    Full Text Available Abstract Background Studies of differential expression that use Affymetrix GeneChip arrays are often carried out with a limited number of replicates. Reasons for this include financial considerations and limits on the available amount of RNA for sample preparation. In addition, failed hybridizations are not uncommon leading to a further reduction in the number of replicates available for analysis. Most existing methods for studying differential expression rely on the availability of replicates and the demand for alternative methods that require few or no replicates is high. Results We describe a statistical procedure for performing differential expression analysis without replicates. The procedure relies on a Bayesian integrated approach (BGX to the analysis of Affymetrix GeneChips. The BGX method estimates a posterior distribution of expression for each gene and condition, from a simultaneous consideration of the available probe intensities representing the gene in a condition. Importantly, posterior distributions of expression are obtained regardless of the number of replicates available. We exploit these posterior distributions to create ranked gene lists that take into account the estimated expression difference as well as its associated uncertainty. We estimate the proportion of non-differentially expressed genes empirically, allowing an informed choice of cut-off for the ranked gene list, adapting an approach proposed by Efron. We assess the performance of the method, and compare it to those of other methods, on publicly available spike-in data sets, as well as in a proper biological setting. Conclusion The method presented is a powerful tool for extracting information on differential expression from GeneChip expression studies with limited or no replicates.

  18. Array processors in chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Ostlund, N.S.

    1980-01-01

    The field of attached scientific processors (''array processors'') is surveyed, and an attempt is made to indicate their present and possible future use in computational chemistry. The current commercial products from Floating Point Systems, Inc., Datawest Corporation, and CSP, Inc. are discussed.

  19. Array Theory and Nial

    DEFF Research Database (Denmark)

    Falster, Peter; Jenkins, Michael

    1999-01-01

    This report is the result of collaboration between the authors during the first 8 months of 1999 when M. Jenkins was visiting professor at DTU. The report documents the development of a tool for the investigation of array theory concepts and in particular presents various approaches to choose...

  20. Detector array and method

    International Nuclear Information System (INIS)

    A detector array and method are described in which sets of electrode elements are provided. Each set consists of a number of linear extending parallel electrodes. The sets of electrode elements are disposed at an angle (preferably orthogonal) with respect to one another so that the individual elements intersect and overlap individual elements of the other sets. Electrical insulation is provided between the overlapping elements. The detector array is exposed to a source of charged particles which in accordance with one embodiment comprise electrons derived from a microchannel array plate exposed to photons. Amplifier and discriminator means are provided for each individual electrode element. Detection means are provided to sense pulses on individual electrode elements in the sets, with coincidence of pulses on individual intersecting electrode elements being indicative of charged particle impact at the intersection of the elements. Electronic readout means provide an indication of coincident events and the location where the charged particle or particles impacted. Display means are provided for generating appropriate displays representative of the intensity and locaton of charged particles impacting on the detector array

  1. The Murchison Widefield Array

    NARCIS (Netherlands)

    Mitchell, Daniel A.; Greenhill, Lincoln J.; Ord, Stephen M.; Bernardi, Gianni

    2010-01-01

    It is shown that the excellent Murchison Radio-astronomy Observatory site allows the Murchison Widefield Array to employ a simple RFI blanking scheme and still calibrate visibilities and form images in the FM radio band. The techniques described are running autonomously in our calibration and imagin

  2. Cantilever array sensors

    Directory of Open Access Journals (Sweden)

    Hans Peter Lang

    2005-04-01

    Full Text Available Miniaturized microfabricated sensors have enormous potential in gas detection, biochemical analysis, medical applications, quality and process control, and product authenticity issues. Here, we highlight an ultrasensitive mechanical way of converting (bio-chemical or physical processes into a recordable signal using microfabricated cantilever arrays.

  3. Expanded mode lasers for telecommunications applications

    Science.gov (United States)

    Lealman, Ian F.

    This thesis describes the development of a long wavelength (1.55 μm) expanded mode semiconductor laser. The increased spot size of the laser improves both the coupling efficiency to cleaved fibre and fibre alignment tolerances and reduces packaging cost. In this type of device the strength of the waveguide is gradually reduced towards the front facet allowing the mode to adiabatically expand so that the laser mode is better matched in size to that of a cleaved fibre. This can be achieved by either reducing the refractive index of the guide or reducing the amount of material in the core. The structure chosen was a buried heterostructure laser that utilised a twin guide consisting of an upper higher refractive index guide (the active region of the laser) above a weak passive guide. The width of the active region was reduced along part of the device allowing the mode to expand into the weak underlying guide. The guide structure was optimised using a variable grid finite difference mode solver, and the taper length calculated by an approximation to Love's method. Detailed results are presented for the measured light-current characteristic, farfield and coupling loss to cleaved fibre. These coupling losses were compared to the calculated data thus allowing the waveguide design to be optimised. Several iterations in the design of the device were undertaken, with the aim of reducing the coupling loss to cleaved single mode fibre without significantly compromising the laser performance. The final device design had extremely low coupling losses as low as 1.2 dB to cleaved fibre. Finally, the positive impact this device had on passive alignment using a silicon motherboard is examined, and the application this technology to a range of other optoelectronic components is discussed.

  4. Effect of support structure on CO2 adsorption properties of pore-expanded hyperbranched aminosilicas

    KAUST Repository

    Drese, Jeffrey H.

    2012-03-01

    Hyperbranched aminosilica (HAS) CO 2 adsorbents are prepared by the ring-opening polymerization of aziridine from SBA-15 mesoporous silica, as in the original synthesis of HAS materials, as well as over an array of new support materials with substantially larger average pore diameters to elucidate the effect of support porosity on final adsorbent properties. Pore-expanded hyperbranched aminosilica (PEHAS) CO 2 adsorbents are prepared from several different pore-expanded, ordered mesoporous silicas including pore-expanded SBA-15, mesocellular foam, and a large-pore commercial silica. The effect of the nature of the silica support is determined by examining the degree of aziridine polymerization and the CO 2 adsorption kinetics and capacities of the resulting organic/inorganic hybrid materials. Comparisons are made to non-pore-expanded SBA-15 based HAS adsorbents, reported previously, where pores become blocked at higher amine loadings. The PEHAS materials unexpectedly possess lower amine loadings than the previously reported HAS materials and do not exhibit pore blocking. The use of acetic acid as a catalyst during PEHAS synthesis only marginally increases amine loading. The adsorption kinetics of PEHAS adsorbents are similar to HAS adsorbents with low amine loadings and do not show the detrimental effects of pore-blocking. However, the inability to synthesize PEHAS adsorbents with high amine loadings via this approach limits the total amount of CO 2 captured per gram of material, compared to HAS adsorbents with high amine loadings. © 2011 Elsevier Inc. All rights reserved.

  5. High-density fiber optic biosensor arrays

    Science.gov (United States)

    Epstein, Jason R.; Walt, David R.

    2002-02-01

    Novel approaches are required to coordinate the immense amounts of information derived from diverse genomes. This concept has influenced the expanded role of high-throughput DNA detection and analysis in the biological sciences. A high-density fiber optic DNA biosensor was developed consisting of oligonucleotide-functionalized, 3.1 mm diameter microspheres deposited into the etched wells on the distal face of a 500 micrometers imaging fiber bundle. Imaging fiber bundles containing thousands of optical fibers, each associated with a unique oligonucleotide probe sequence, were the foundation for an optically connected, individually addressable DNA detection platform. Different oligonucleotide-functionalized microspheres were combined in a stock solution, and randomly dispersed into the etched wells. Microsphere positions were registered from optical dyes incorporated onto the microspheres. The distribution process provided an inherent redundancy that increases the signal-to-noise ratio as the square root of the number of sensors examined. The representative amount of each probe-type in the array was dependent on their initial stock solution concentration, and as other sequences of interest arise, new microsphere elements can be added to arrays without altering the existing detection capabilities. The oligonucleotide probe sequences hybridize to fluorescently-labeled, complementary DNA target solutions. Fiber optic DNA microarray research has included DNA-protein interaction profiles, microbial strain differentiation, non-labeled target interrogation with molecular beacons, and single cell-based assays. This biosensor array is proficient in DNA detection linked to specific disease states, single nucleotide polymorphism (SNP's) discrimination, and gene expression analysis. This array platform permits multiple detection formats, provides smaller feature sizes, and enables sensor design flexibility. High-density fiber optic microarray biosensors provide a fast

  6. Michelin Group Accelerating the Steps for Expanding

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    1.Investing USD 750 Million to Build All-steel Giant Tire Plant in USA The French tire manufacturer Michelin Group announced in April 10 that in order to improve the production capacity of giant tires used for engineering equipments, the Group planned to invest USD 750 million to build the second engineering tire plant in Anderson County, South Carolina, USA. The plant would start to be built within a few weeks and was expected to be completed and put into production by the end of 2013. This Group would also expand the engineering tire plant located in Lexington County of this State,

  7. Expanding the frontiers of neutron scattering

    International Nuclear Information System (INIS)

    Accelerator based pulsed neutron sources have in recent years significantly expanded the frontiers of neutron scattering as a microscopic probe of the condensed states of matter. This paper discusses why such sources have been developed, and what their advantages are over conventional steady state sources. Particular reference is made to the most advanced of the present generation of pulsed neutron sources, the UK pulsed spallation source ISIS. Scientific advantages are illustrated using recent examples of structural and dynamical studies from the science programme at ISIS. The development potential of pulsed sources, both in terms of new instrumentation and new sources, is also discussed, with particular reference to the proposed European Spallation Source. (author)

  8. Mining Energy in an Expanding Universe

    Science.gov (United States)

    Harrison, Edward R.

    1995-06-01

    In principle, the expansion of the universe can be harnessed to provide energy. In a gedankenexperiment, energy is gained by connecting together widely separated bodies with strings. The tension and the energy generated are calculated for single strings. Mining energy in an expanding universe in this way raises unresolved issues concerning the conservation of energy. Apparently, the tethered-body experiment delivers "nascent" energy that previously did not exist in any identifiable and quantifiable form. It is argued that energy in a homogeneous and unbounded universe, in general, is not conserved on the cosmic scale.

  9. Concurrent Manipulation of Expanded AVL Trees

    Institute of Scientific and Technical Information of China (English)

    章寅; 许卓群

    1998-01-01

    The concurrent manipulation of an expanded AVL tree(EAVL tree)s considered in this paper.The presented system can support any number of concurrent processes which perform searching,insertion and deletion on the tree.Simulation results indicate the high performance of the system.Elaborate techniques are used to achieve such a system unavailable based on any known algorithms.Methods developed in this paper may provide new insights into other problems in the area of concurrent search structure manipulation.

  10. The kinetic theory of expanding QGP

    International Nuclear Information System (INIS)

    We investigate a new variant of flux-tube model based on joint action of two different processes responsible for the vacuum particle creation: the standard Schwinger mechanism and the geometrical mechanism, caused by the dynamical Casimir effect. It is assumed that pre-equilibrium quark-gluon plasma (QGP), created in ultrarelativistic heavy-ion collisions and, therefore, confined within the expanding cylinder, is under action of strong chromoelectric fields. According to considered model, these two mechanisms act at different time scales and lead to qualitatively different momentum distributions that might be observed experimentally

  11. A functional gene array for detection of bacterial virulence elements

    Energy Technology Data Exchange (ETDEWEB)

    Jaing, C

    2007-11-01

    We report our development of the first of a series of microarrays designed to detect pathogens with known mechanisms of virulence and antibiotic resistance. By targeting virulence gene families as well as genes unique to specific biothreat agents, these arrays will provide important data about the pathogenic potential and drug resistance profiles of unknown organisms in environmental samples. To validate our approach, we developed a first generation array targeting genes from Escherichia coli strains K12 and CFT073, Enterococcus faecalis and Staphylococcus aureus. We determined optimal probe design parameters for microorganism detection and discrimination, measured the required target concentration, and assessed tolerance for mismatches between probe and target sequences. Mismatch tolerance is a priority for this application, due to DNA sequence variability among members of gene families. Arrays were created using the NimbleGen Maskless Array Synthesizer at Lawrence Livermore National Laboratory. Purified genomic DNA from combinations of one or more of the four target organisms, pure cultures of four related organisms, and environmental aerosol samples with spiked-in genomic DNA were hybridized to the arrays. Based on the success of this prototype, we plan to design further arrays in this series, with the goal of detecting all known virulence and antibiotic resistance gene families in a greatly expanded set of organisms.

  12. Phased-array vector velocity estimation using transverse oscillations

    DEFF Research Database (Denmark)

    Pihl, Michael Johannes; Marcher, Jønne; Jensen, Jørgen Arendt

    2012-01-01

    of the TO method using a phased-array transducer for vector velocity estimation is evaluated through simulation and flow-rig measurements are acquired using an experimental scanner. The vast number of calculations needed to perform flow simulations makes the optimization of the TO fields a cumbersome process......A method for estimating the 2-D vector velocity of blood using a phased-array transducer is presented. The approach is based on the transverse oscillation (TO) method. The purposes of this work are to expand the TO method to a phased-array geometry and to broaden the potential clinical....... Therefore, three performance metrics are proposed. They are calculated based on the complex TO spectrum of the combined TO fields. It is hypothesized that the performance metrics are related to the performance of the velocity estimates. The simulations show that the squared correlation values range from 0...

  13. "Phase freezeout" in isentropically expanding matter

    CERN Document Server

    Iosilevskiy, Igor

    2014-01-01

    Features of isentropic expansion of warm dense matter (WDM) created by intense energy fluxes (strong shock compression or instant isochoric heating by laser or heavy ions) are under discussion in situation when ($i$) -- thermodynamic trajectory of such expansion crosses binodal of liquid-gas phase transition, and ($ii$) -- expansion within the two-phase region is going along equilibrium branch (not metastable one) of the two-phase mixture isentrope. It is known in the plane case that because of break in the expansion isentrope at binodal point (in $P-V$ plane) i.e. jump of sound velocity in this point, there appears extended zone ("boiling layer") of uniformity in expanding material with constant thermodynamic and kinematic parameters. It corresponds just to the state on this binodal of boiling liquid. The point is that because of self-similarity of such expansion (in plane case) this boiling layer contains finite and fixed part of whole expanding material. This property makes it possible (at least formally) ...

  14. Concurrent array-based queue

    Energy Technology Data Exchange (ETDEWEB)

    Heidelberger, Philip; Steinmacher-Burow, Burkhard

    2015-01-06

    According to one embodiment, a method for implementing an array-based queue in memory of a memory system that includes a controller includes configuring, in the memory, metadata of the array-based queue. The configuring comprises defining, in metadata, an array start location in the memory for the array-based queue, defining, in the metadata, an array size for the array-based queue, defining, in the metadata, a queue top for the array-based queue and defining, in the metadata, a queue bottom for the array-based queue. The method also includes the controller serving a request for an operation on the queue, the request providing the location in the memory of the metadata of the queue.

  15. An Expanding Locally Anisotropic (ELA) Metric Describing Matter in an Expanding Universe

    OpenAIRE

    Ferreira, P. Castelo

    2010-01-01

    It is suggested an expanding locally anisotropic metric (ELA) ansatz describing matter in a flat expanding universe which interpolates between the Schwarzschild (SC) metric near point-like central bodies of mass 'M' and the Robertson-Walker (RW) metric for large radial coordinate: 'ds^2=Z(cdt)2 - 1/Z (dr1-(Hr1/c) Z^(alpha/2+1/2)(cdt))^2-r1^2 dOmega', where 'Z=1-U' with 'U=2GM/(c^2r1)', 'G' is the Newton constant, 'c' is the speed of light, 'H=H(t)=\\dot(a)/a' is the time-dependent Hubble rate,...

  16. Radar techniques using array antennas

    CERN Document Server

    Wirth, Wulf-Dieter

    2013-01-01

    Radar Techniques Using Array Antennas is a thorough introduction to the possibilities of radar technology based on electronic steerable and active array antennas. Topics covered include array signal processing, array calibration, adaptive digital beamforming, adaptive monopulse, superresolution, pulse compression, sequential detection, target detection with long pulse series, space-time adaptive processing (STAP), moving target detection using synthetic aperture radar (SAR), target imaging, energy management and system parameter relations. The discussed methods are confirmed by simulation stud

  17. Timed arrays wideband and time varying antenna arrays

    CERN Document Server

    Haupt, Randy L

    2015-01-01

    Introduces timed arrays and design approaches to meet the new high performance standards The author concentrates on any aspect of an antenna array that must be viewed from a time perspective. The first chapters briefly introduce antenna arrays and explain the difference between phased and timed arrays. Since timed arrays are designed for realistic time-varying signals and scenarios, the book also reviews wideband signals, baseband and passband RF signals, polarization and signal bandwidth. Other topics covered include time domain, mutual coupling, wideband elements, and dispersion. The auth

  18. Microreactor Array Device

    Science.gov (United States)

    Wiktor, Peter; Brunner, Al; Kahn, Peter; Qiu, Ji; Magee, Mitch; Bian, Xiaofang; Karthikeyan, Kailash; Labaer, Joshua

    2015-03-01

    We report a device to fill an array of small chemical reaction chambers (microreactors) with reagent and then seal them using pressurized viscous liquid acting through a flexible membrane. The device enables multiple, independent chemical reactions involving free floating intermediate molecules without interference from neighboring reactions or external environments. The device is validated by protein expressed in situ directly from DNA in a microarray of ~10,000 spots with no diffusion during three hours incubation. Using the device to probe for an autoantibody cancer biomarker in blood serum sample gave five times higher signal to background ratio compared to standard protein microarray expressed on a flat microscope slide. Physical design principles to effectively fill the array of microreactors with reagent and experimental results of alternate methods for sealing the microreactors are presented.

  19. Optically interconnected phased arrays

    Science.gov (United States)

    Bhasin, Kul B.; Kunath, Richard R.

    1988-01-01

    Phased-array antennas are required for many future NASA missions. They will provide agile electronic beam forming for communications and tracking in the range of 1 to 100 GHz. Such phased arrays are expected to use several hundred GaAs monolithic integrated circuits (MMICs) as transmitting and receiving elements. However, the interconnections of these elements by conventional coaxial cables and waveguides add weight, reduce flexibility, and increase electrical interference. Alternative interconnections based on optical fibers, optical processing, and holography are under evaluation as possible solutions. In this paper, the current status of these techniques is described. Since high-frequency optical components such as photodetectors, lasers, and modulators are key elements in these interconnections, their performance and limitations are discussed.

  20. Atacama Compact Array Antennas

    CERN Document Server

    Saito, Masao; Nakanishi, Kouichiro; Naoi, Takahiro; Yamada, Masumi; Saito, Hiro; Ikenoue, Bungo; Kato, Yoshihiro; Morita, Kou-ichiro; Mizuno, Norikazu; Iguchi, Satoru

    2011-01-01

    We report major performance test results of the Atacama Compact Array (ACA) 7-m and 12-m antennas of ALMA (Atacama Large Millimeter/submillimeter Array). The four major performances of the ACA antennas are all-sky pointing (to be not more than 2.0 arcsec), offset pointing (to be < 0.6 arcsec) surface accuracy (< 25(20) micrometer for 12(7)m-antenna), stability of path-length (15 micrometer over 3 min), and high servo capability (6 degrees/s for Azimuth and 3 degrees/s for Elevation). The high performance of the ACA antenna has been extensively evaluated at the Site Erection Facility area at an altitude of about 2900 meters. Test results of pointing performance, surface performance, and fast motion capability are demonstrated.

  1. First order phase transition of expanding matter and its fragmentation

    Energy Technology Data Exchange (ETDEWEB)

    Chikazumi, Shinpei [Tsukuba Univ., Institute of Physics, Tsukuba, Ibaraki (Japan); Iwamoto, Akira [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2002-09-01

    Using an expanding matter model with a Lennard-Jones potential, the instability of the expanding system is investigated. The pressure, the temperature, and the density fluctuations are calculated as functions of density during the time evolution of the expanding matter, which are compared to the coexistence curve calculated by the Gibbs ensemble. The expanding matter undergoes the first order phase transition in the limit of the quasistatic expansion. The resultant fragment mass distributions are also investigated. (author)

  2. Optical cavity resonator in an expanding universe

    Science.gov (United States)

    Kopeikin, Sergei M.

    2015-02-01

    We study the cosmological evolution of frequency of a standing electromagnetic wave in a resonant optical cavity placed to the expanding manifold described by the Robertson-Walker metric. Because of the Einstein principle of equivalence (EEP), one can find a local coordinate system (a local freely falling frame), in which spacetime is locally Minkowskian. However, due to the conformal nature of the Robertson-Walker metric the conventional transformation to the local inertial coordinates introduces ambiguity in the physical interpretation of the local time coordinate, . Therefore, contrary to a common-sense expectation, a straightforward implementation of EEP alone does not allow us to unambiguously decide whether atomic clocks based on quantum transitions of atoms, ticks at the same rate as the clocks based on electromagnetic modes of a cavity. To resolve this ambiguity we have to analyse the cavity rigidity and the oscillation of its electromagnetic modes in an expanding universe by employing the full machinery of the Maxwell equations irrespectively of the underlying theory of gravity. We proceed in this way and found out that the size of the cavity and the electromagnetic frequency experience an adiabatic drift in conformal (unphysical) coordinates as the universe expands in accordance with the Hubble law. We set up the oscillation equation for the resonant electromagnetic modes, solve it by the WKB approximation, and reduce the coordinate-dependent quantities to their counterparts measured by a local observer who counts time with atomic clock. The solution shows that there is a perfect mutual cancellation of the adiabatic drift of cavity's frequency by space transformation to local coordinates and the time counted by the clocks based on electromagnetic modes of cavity has the same rate as that of atomic clocks. We conclude that if general relativity is correct and the local expansion of space is isotropic there should be no cosmological drift of frequency of a

  3. Expandable intramedullary nail - experimental biomechanical evaluation

    Directory of Open Access Journals (Sweden)

    A. Kajzer

    2010-01-01

    Full Text Available Purpose: The paper presents results of experimental analysis of femur and femur – expandable intramedullary nail system. The aim of the work was to determine displacement in three models. In addition, the torsion of the system aiming at determining the moments depending on the torsional angle of the bone was carried out.Design/methodology/approach: Three femurs were selected for studies. The analysis was carried out on the femur – expandable intramedullary nail system. The influence of the loads and displacements on the bone – nail system on the results of experimental analysis was analysed. In order to carry out calculations, three models were selected: model I – bone without fracture gap, model II and III – femur with expansion intramedullary nails – fracture gap was located 100 mm under greater trochanter. The studies were performed on femur models produced by Swedish company Sawbones. The intramedullary „Fixion IM” nails (Ti-6Al-4V alloy were implanted into the bone. Displacements of determinated models were being recorded from the sensors every 100 N from 10 N to 2000 N.Findings: The analyses showed the difference in displacements, depending on the selected models.Research limitations/implications: The limitations were connected with simplification of boundary conditions during analysis which were the result of the simplification of the models. While studying, muscles and ligaments supporting the bone in anatomic position were not taken into consideration. Instead, the system has been loaded with the axial force (compression.Practical implications: The obtained results can be useful in clinical practice. They can be applied in selection of stabilization methods or rehabilitation as well as in describing the biomechanical conditions connected with type of bone fracture obtained from medical imaging.Originality/value: . The work compares the values of displacement of characteristic points of femur (healthy – model I with the

  4. The Expanding Marketplace for Applied Geophysics

    Science.gov (United States)

    Carlson, N.; Sirles, P.

    2012-12-01

    While the image of geophysics for the proverbial "layman" often seems limited to volcanoes and earthquakes, and to the geoscientist this image enlarges to include oil or minerals exploration and whole earth studies, there has been a steady increase in the application of geophysics into the realm of "daily life", such as real estate deals, highway infrastructure, and flood protection. This expansion of applications can be attributed to the improved economics from advances in equipment and interpretation. Traditional geophysical methods that at one time often only fit within the budgets of oil, gas, and minerals exploration programs can now be economically applied to much smaller scale needs like contaminant mapping, landfill delineation, and levee investigations. A real-world, economic example of this expanding marketplace is our company, which began very small and was aimed almost exclusively at the minerals exploration market. Most of our growth has been in the last 10 years, when we have expanded to five offices and a staff with almost 40 geoscientist degrees (21 in geophysics); much of this growth has been in the non-oil, non-minerals arenas. While much of our work still includes minerals exploration, other projects this year include wind-farm foundation studies, cavity detection above underground nuclear tests, landfill studies, acid mine drainage problems, and leaks in evaporation ponds. A methodology example of this expanding market is the induced polarization (IP) survey, once primarily used for minerals exploration, particularly large porphyry copper deposits, but now efficient enough to also use in environmental studies. The IP method has been particularly useful in delineating and characterizing old, poorly documented landfills, and recent research suggests it may also be useful in monitoring the accelerated biodegradation processes used in some cases to rehabilitate the sites. Compared to temperature monitoring systems, IP may be more useful in providing

  5. The Murchison Widefield Array

    CERN Document Server

    Mitchell, Daniel A; Ord, Stephen M; Bernardi, Gianni; Wayth, Randall B; Edgar, Richard G; Clark, Michael A; Dal, Kevin; Pfister, Hanspeter; Gleadow, Stewart J; Arcus, W; Briggs, F H; Benkevitch, L; Bowman, J D; Bunton, J D; Burns, S; Cappallo, R J; Corey, B E; de Oliveira-Costa, A; Desouza, L; Doeleman, S S; Derome, M F; Emrich, D; Glossop, M; Goeke, R; Krishna, M R Gopala; Hazelton, B; Herne, D E; Hewitt, J N; Kamini, P A; Kaplan, D L; Kasper, J C; Kincaid, B B; Kocz, J; Kowald, E; Kratzenberg, E; Kumar, D; Lonsdale, C J; Lynch, M J; Madhavi, S; Matejek, M; McWhirter, S R; Morales, M F; Morgan, E; Oberoi, D; Pathikulangara, J; Prabu, T; Rogers, A; Salah, J E; Sault, R J; Shankar, N Udaya; Srivani, K S; Stevens, J; Tingay, S J; Vaccarella, A; Waterson, M; Webster, R L; Whitney, A R; Williams, A; Williams, C

    2010-01-01

    It is shown that the excellent Murchison Radio-astronomy Observatory site allows the Murchison Widefield Array to employ a simple RFI blanking scheme and still calibrate visibilities and form images in the FM radio band. The techniques described are running autonomously in our calibration and imaging software, which is currently being used to process an FM-band survey of the entire southern sky.

  6. The Square Kilometre Array

    OpenAIRE

    Lazio, Joseph

    2009-01-01

    The Square Kilometre Array (SKA) is intended as the next-generation radio telescope and will address fundamental questions in astrophysics, physics, and astrobiology. The international science community has developed a set of Key Science Programs: (1) Emerging from the Dark Ages and the Epoch of Reionization, (2) Galaxy Evolution, Cosmology, and Dark Energy, (3) The Origin and Evolution of Cosmic Magnetism, (4) Strong Field Tests of Gravity Using Pulsars and Black Holes, and (5) The Cradle of...

  7. The Cherenkov Telescope Array

    OpenAIRE

    Bigongiari, Ciro

    2016-01-01

    The Cherenkov Telescope Array (CTA) is planned to be the next generation ground based observatory for very high energy (VHE) gamma-ray astronomy. Gamma-rays provide a powerful insight into the non-thermal universe and hopefully a unique probe for new physics. Imaging Cherenkov telescopes have already discovered more than 170 VHE gamma-ray emitters providing plentiful of valuable data and clearly demonstrating the power of this technique. In spite of the impressive results there are indication...

  8. The Submillimeter Array Polarimeter

    OpenAIRE

    Marrone, Daniel P.; Rao, Ramprasad

    2008-01-01

    We describe the Submillimeter Array (SMA) Polarimeter, a polarization converter and feed multiplexer installed on the SMA. The polarimeter uses narrow-band quarter-wave plates to generate circular polarization sensitivity from the linearly-polarized SMA feeds. The wave plates are mounted in rotation stages under computer control so that the polarization handedness of each antenna is rapidly selectable. Positioning of the wave plates is found to be highly repeatable, better than 0.2 degrees. A...

  9. Solar collector array

    Science.gov (United States)

    Hall, John Champlin; Martins, Guy Lawrence

    2015-09-06

    A method and apparatus for efficient manufacture, assembly and production of solar energy. In one aspect, the apparatus may include a number of modular solar receiver assemblies that may be separately manufactured, assembled and individually inserted into a solar collector array housing shaped to receive a plurality of solar receivers. The housing may include optical elements for focusing light onto the individual receivers, and a circuit for electrically connecting the solar receivers.

  10. Supersymetric laser arrays

    OpenAIRE

    El-Ganainy, Ramy; Ge, Li; Khajavikhan, Mercedeh; Christodoulides, Demetrios

    2015-01-01

    We introduce the concept of supersymmetric laser arrays that consists of a main optical lattice and its superpartner structure, and we investigate the onset of their lasing oscillations. Due to the coupling of the two constituent lattices, their degenerate optical modes form doublets, while the extra mode associated with unbroken supersymmetry forms a singlet state. Singlet lasing can be achieved for a wide range of design parameters either by introducing stronger loss in the partner lattice ...

  11. Microphone array proccesing

    OpenAIRE

    Navarro Contreras, Héctor Ángel

    2010-01-01

    Microphone arrays consist of multiple microphones functioning as a single directional input device: essentially, an acoustic antenna. Using sound propagation principles, the principal sound sources in an environment can be spatially located. Distinguishing sounds based on the spatial location of their source is achieved by filtering and combining the individual microphone signals. The location of the principal sounds sources may be determined dynamically by analyzing peaks i...

  12. Seismometer array station processors

    International Nuclear Information System (INIS)

    A description is given of the design, construction and initial testing of two types of Seismometer Array Station Processor (SASP), one to work with data stored on magnetic tape in analogue form, the other with data in digital form. The purpose of a SASP is to detect the short period P waves recorded by a UK-type array of 20 seismometers and to edit these on to a a digital library tape or disc. The edited data are then processed to obtain a rough location for the source and to produce seismograms (after optimum processing) for analysis by a seismologist. SASPs are an important component in the scheme for monitoring underground explosions advocated by the UK in the Conference of the Committee on Disarmament. With digital input a SASP can operate at 30 times real time using a linear detection process and at 20 times real time using the log detector of Weichert. Although the log detector is slower, it has the advantage over the linear detector that signals with lower signal-to-noise ratio can be detected and spurious large amplitudes are less likely to produce a detection. It is recommended, therefore, that where possible array data should be recorded in digital form for input to a SASP and that the log detector of Weichert be used. Trial runs show that a SASP is capable of detecting signals down to signal-to-noise ratios of about two with very few false detections, and at mid-continental array sites it should be capable of detecting most, if not all, the signals with magnitude above msub(b) 4.5; the UK argues that, given a suitable network, it is realistic to hope that sources of this magnitude and above can be detected and identified by seismological means alone. (author)

  13. Spaceborne Processor Array

    Science.gov (United States)

    Chow, Edward T.; Schatzel, Donald V.; Whitaker, William D.; Sterling, Thomas

    2008-01-01

    A Spaceborne Processor Array in Multifunctional Structure (SPAMS) can lower the total mass of the electronic and structural overhead of spacecraft, resulting in reduced launch costs, while increasing the science return through dynamic onboard computing. SPAMS integrates the multifunctional structure (MFS) and the Gilgamesh Memory, Intelligence, and Network Device (MIND) multi-core in-memory computer architecture into a single-system super-architecture. This transforms every inch of a spacecraft into a sharable, interconnected, smart computing element to increase computing performance while simultaneously reducing mass. The MIND in-memory architecture provides a foundation for high-performance, low-power, and fault-tolerant computing. The MIND chip has an internal structure that includes memory, processing, and communication functionality. The Gilgamesh is a scalable system comprising multiple MIND chips interconnected to operate as a single, tightly coupled, parallel computer. The array of MIND components shares a global, virtual name space for program variables and tasks that are allocated at run time to the distributed physical memory and processing resources. Individual processor- memory nodes can be activated or powered down at run time to provide active power management and to configure around faults. A SPAMS system is comprised of a distributed Gilgamesh array built into MFS, interfaces into instrument and communication subsystems, a mass storage interface, and a radiation-hardened flight computer.

  14. Array processor architecture

    Science.gov (United States)

    Barnes, George H. (Inventor); Lundstrom, Stephen F. (Inventor); Shafer, Philip E. (Inventor)

    1983-01-01

    A high speed parallel array data processing architecture fashioned under a computational envelope approach includes a data base memory for secondary storage of programs and data, and a plurality of memory modules interconnected to a plurality of processing modules by a connection network of the Omega gender. Programs and data are fed from the data base memory to the plurality of memory modules and from hence the programs are fed through the connection network to the array of processors (one copy of each program for each processor). Execution of the programs occur with the processors operating normally quite independently of each other in a multiprocessing fashion. For data dependent operations and other suitable operations, all processors are instructed to finish one given task or program branch before all are instructed to proceed in parallel processing fashion on the next instruction. Even when functioning in the parallel processing mode however, the processors are not locked-step but execute their own copy of the program individually unless or until another overall processor array synchronization instruction is issued.

  15. Synthetic Genetic Array Analysis.

    Science.gov (United States)

    Kuzmin, Elena; Costanzo, Michael; Andrews, Brenda; Boone, Charles

    2016-01-01

    Genetic interaction studies have been used to characterize unknown genes, assign membership in pathway and complex, and build a comprehensive functional map of a eukaryotic cell. Synthetic genetic array (SGA) methodology automates yeast genetic analysis and enables systematic mapping of genetic interactions. In its simplest form, SGA consists of a series of replica pinning steps that enable construction of haploid double mutants through automated mating and meiotic recombination. Using this method, a strain carrying a query mutation, such as a deletion allele of a nonessential gene or a conditional temperature-sensitive allele of an essential gene, can be crossed to an input array of yeast mutants, such as the complete set of approximately 5000 viable deletion mutants. The resulting output array of double mutants can be scored for genetic interactions based on estimates of cellular fitness derived from colony-size measurements. The SGA score method can be used to analyze large-scale data sets, whereas small-scale data sets can be analyzed using SGAtools, a simple web-based interface that includes all the necessary analysis steps for quantifying genetic interactions. PMID:27037072

  16. Markovian stochastic approximation with expanding projections

    CERN Document Server

    Andrieu, Christophe

    2011-01-01

    Stochastic approximation is a framework unifying many random iterative algorithms occurring in a diverse range of applications. The stability of the process is often difficult to verify in practical applications and the process may even be unstable without additional stabilisation techniques. We study a stochastic approximation procedure with expanding projections similar to Andrad\\'ottir [Oper. Res. 43 (2010) 1037--1048]. We focus on Markovian noise and show the stability and convergence under general conditions. Our framework also incorporates the possibility to use a random step size sequence, which allows us to consider settings with a non-smooth family of Markov kernels. We apply the theory to stochastic approximation expectation maximisation with particle independent Metropolis-Hastings sampling.

  17. Henry Norris Russell and the Expanding Universe

    Science.gov (United States)

    DeVorkin, D.

    2013-04-01

    Henry Norris Russell, one of the most influential American astronomers of the first half of the 20th Century, had a special place in his heart for the Lowell Observatory. Although privately critical of the founder for his pronouncements about life on Mars and the superiority of the Mars Hill observing site, he always supported the Observatory in public and professional circles. He staunchly supported Tombaugh's detection of a planet as leading from Lowell's prediction, and always promoted V. M. Slipher's spectroscopic investigations of planetary and stellar phenomena. But how did he react to Slipher's puzzling detection of the extreme radial velocities of spiral nebulae starting in 1912, and how did he regard the extension and interpretation of those observations by Hubble and others in following decades? Here we describe the arc of Russell's reactions, dating from Slipher's first detection, as an indicator of how mainstream stellar astronomers reacted to the concept of an expanding universe.

  18. Expanding Policy Imagination in Political Economy

    DEFF Research Database (Denmark)

    Seabrooke, Leonard

    2006-01-01

    Much of the literature in political economy seeks to capture an essential insight into the evolution of political and economic systems to provide a foundation for policy advice. This article suggests that attempts to nut out the kernels of change often restrict rather than expand policy imagination...... capacity to see political, social, and economic changes that do not conform to conventional theories, as well as distorting our understanding of how the contemporary world works. What policymakers want, more than prediction or recitation of conventional theories, is context to understand how policy can be...... implemented. Historical sociology provides a way to generate information about contextual constellations through two "tonics": intentional rationality and social mechanisms. With the assistance of these tonics, historical sociology widens political economy's policy imagination....

  19. Instabilities in non-expanding glasma

    CERN Document Server

    Fujii, H; Iwazaki, A

    2009-01-01

    A homogeneous color magnetic field is known to be unstable for the fluctuations perpendicular to the field in the color space (the Nielsen-Olesen instability). We argue that these unstable modes, exponentially growing, generate an azimuthal magnetic field with the original field being in the $z$-direction, which causes the Nielsen-Olesen instability for another type of fluctuations. The growth rate of the latter unstable mode increases with the momentum $p_z$ and can become larger than the former's growth rate which decreases with increasing $p_z$. These features may explain the interplay between the primary and secondary instabilities observed in the real-time simulation of a non-expanding glasma, i.e., stochastically generated anisotropic Yang-Mills fields without expansion.

  20. On memory in exponentially expanding spaces

    CERN Document Server

    Roberts, Daniel A

    2012-01-01

    We examine the degree to which fluctuating dynamics on exponentially expanding spaces remember initial conditions. In de Sitter space, the global late-time configuration of a free scalar field always contains information about early fluctuations. By contrast, fluctuations near the boundary of Euclidean Anti-de Sitter may or may not remember conditions in the center, with a transition at \\Delta=d/2. We connect these results to literature about statistical mechanics on trees and make contact with the observation by Anninos and Denef that the configuration space of a massless dS field exhibits ultrametricity. We extend their analysis to massive fields, finding that preference for isosceles triangles persists as long as \\Delta_- < d/4.

  1. Celestial Ephemerides in an Expanding Universe

    CERN Document Server

    Kopeikin, Sergei

    2012-01-01

    Post-Newtonian theory was instrumental in conducting the critical experimental tests of general relativity and in building the astronomical ephemerides of celestial bodies in the solar system with an unparalleled precision. The cornerstone of the theory is the postulate that the solar system is gravitationally isolated from the rest of the universe and the background spacetime is asymptotically flat. The present article extends this theoretical concept and formulates the principles of celestial dynamics of particles and light moving in gravitational field of a localized astronomical system embedded to the expanding Friedmann-Lemaitre-Robertson-Walker (FLRW) universe. We formulate the precise mathematical concept of the Newtonian limit of Einstein's field equations in the conformally-flat FLRW spacetime and analyze the geodesic motion of massive particles and light in this limit. We prove that by doing conformal spacetime transformations, one can reduce the equations of motion of particles and light to the cla...

  2. Helical chirality induction of expanded porphyrin analogues

    Indian Academy of Sciences (India)

    Jun-Ichiro Setsune

    2012-11-01

    Expanded porphyrin analogues with unique figure-eight conformation were prepared by way of useful pyrrole intermediates such as bis(azafulvene)s and 2-borylpyrrole. Supramolecular chirogenesis of cyclooctapyrrole O1 with 32-cycloconjugation was successfully applied to determine absolute configuration of chiral carboxylic acids. Dinuclear CuII complex of cyclooctapyrrole O2 with interrupted -conjugation was resolved by HPLC into enantiomers and their helical handedness was determined by theoretical simulation of their CD spectral pattern. Enantioselective induction of helicity in the metal helicate formation in the presence of a chiral promoter was demonstrated by using ()-(+)-1-(1-phenyl)ethylamine that favoured , helicity. Dinuclear CoII complexes of cyclotetrapyrroletetrapyridine O3 were found to be substitution labile and pick up amino acid anions in water. Those amino acid complexes of O3Co2 were rendered to adopt a particular unidirectional helical conformation preferentially depending on the ligated amino acid anion.

  3. Homogeneous cosmology with aggressively expanding civilizations

    CERN Document Server

    Olson, S Jay

    2014-01-01

    In the context of a homogeneous universe, we note that the appearance of aggressively expanding advanced life is geometrically similar to the process of nucleation and bubble growth in a first-order cosmological phase transition. We exploit this similarity to describe the dynamics of life saturating the universe on a cosmic scale, adapting the phase transition model to incorporate probability distributions of expansion and resource consumption strategies. Through a series of numerical solutions covering several orders of magnitude in the input assumption parameters, the resulting cosmological model is used to address basic questions related to the intergalactic spreading of life, dealing with issues such as timescales, observability, competition between strategies, and first-mover advantage. Finally, we examine physical effects on the universe itself, such as reheating and the backreaction on the evolution of the scale factor, if such life is able to control and convert a significant fraction of the available...

  4. Withdrawal: Expanding a Key Addiction Construct.

    Science.gov (United States)

    Piper, Megan E

    2015-12-01

    Withdrawal is an essential component of classical addiction theory; it is a vital manifestation of dependence and motivates relapse. However, the traditional conceptualization of withdrawal as a cohesive collection of symptoms that emerge during drug deprivation and decline with either the passage of time or reinstatement of drug use, may be inadequate to explain scientific findings or fit with modern theories of addiction. This article expands the current understanding of tobacco withdrawal by examining: (1) withdrawal variability; (2) underlying causes of withdrawal variability, including biological and person factors, environmental influences, and the influence of highly routinized behavioral patterns; (3) new withdrawal symptoms that allow for enhanced characterization of the withdrawal experience; and (4) withdrawal-related cognitive processes. These topics provide guidance regarding the optimal assessment of withdrawal and illustrate the potential impact modern withdrawal conceptualization and assessment could have on identifying treatment targets. PMID:25744958

  5. Heptaphyrins: Expanded porphyrins with seven heterocyclic rings

    Indian Academy of Sciences (India)

    Venkataramanarao G Anand; Simi K Pushpan; Sundararaman Venkatraman; Tavarekere K Chandrashekar

    2003-10-01

    Expanded porphyrins containing seven pyrrole/heterocyclic rings linked in a cyclic fashion are termed heptaphyrins. The number of -electrons in heptaphyrins depends on the number of meso carbon bridges used to link the heterocyclic rings, accordingly heptaphyrins with 28-electrons and 30 -electrons are reported to date. Both condensation reactions of the appropriate precursors and acid-catalysed oxidative coupling reactions have been utilized to synthesise the heptaphyrins. The 30 heptaphyrins exhibit rich structural diversity where some of the heterocyclic rings in the macrocycle undergo a 180° ring flipping. An overview of the synthetic methods employed for the synthesis of heptaphyrins, their spectroscopic properties, structural behaviour and aromatic properties are highlighted in this paper.

  6. Cosmic strings in an expanding spacetime

    International Nuclear Information System (INIS)

    We investigate the stability of a static, infinitely long and straight vacuum string solution under inhomogeneous axisymmetric time-dependent perturbations. We find it to be perturbatively stable. We further extend our work by finding a string solutions in an expanding Universe. The back reaction of the string on the gravitational field has been ignored. The background is assumed to be a Friedman-Robertson-Walker (FRW) cosmology. By numerically integrating the field equations in a radiation and matter dominated models, we discover oscillatory solutions. The possible damping of these oscillations is discussed. For late times the solution becomes identical to the static one studied in the first part of the paper. 19 refs., 8 figs

  7. The expanding spectrum of cutaneous borreliosis.

    Science.gov (United States)

    Eisendle, K; Zelger, B

    2009-04-01

    The known spectrum of skin manifestations in cutaneous Lyme disease is continuously expanding and can not be regarded as completed. Besides the classical manifestations of cutaneous borreliosis like erythema (chronicum) migrans, borrelial lymphocytoma and acrodermatitis chronica atrophicans evidence is growing that at least in part also other skin manifestations, especially morphea, lichen sclerosus and cases of cutaneous B-cell lymphoma are causally related to infections with Borrelia. Also granuloma annulare and interstitial granulomatous dermatitis might be partly caused by Borrelia burgdorferi or similar strains. There are also single reports of other skin manifestations to be associated with borrelial infections like cutaneous sarcoidosis, necrobiosis lipoidica and necrobiotic xanthogranuloma. In addition, as the modern chameleon of dermatology, cutaneous borreliosis, especially borrelial lymphocytoma, mimics other skin conditions, as has been shown for erythema annulare centrifugum or lymphocytic infiltration (Jessner Kanof) of the skin. PMID:19357623

  8. Henry Norris Russell and the Expanding Universe

    CERN Document Server

    DeVorkin, David H

    2013-01-01

    Henry Norris Russell, one of the most influential American astronomers of the first half of the 20th Century, had a special place in his heart for the Lowell Observatory. Although privately critical of the founder for his pronouncements about life on Mars and the superiority of the Mars Hill observing site, he always supported the Observatory in public and professional circles. He staunchly supported Tombaugh's detection of a planet as leading from Lowell's prediction, and always promoted V. M. Slipher's spectroscopic investigations of planetary and stellar phenomena. But how did he react to Slipher's puzzling detection of the extreme radial velocities of spiral nebulae starting in 1912, and how did he regard the extension and interpretation of those observations by Hubble and others in following decades? Here we describe the arc of Russell's reactions, dating from Slipher's first detection, as an indicator of how mainstream stellar astronomers reacted to the concept of an expanding universe.

  9. Single-nucleotide polymorphism array-based karyotyping of acute promyelocytic leukemia.

    Directory of Open Access Journals (Sweden)

    Inés Gómez-Seguí

    Full Text Available Acute promyelocytic leukemia (APL is characterized by the t(15;17(q22;q21, but additional chromosomal abnormalities (ACA and other rearrangements can contribute in the development of the whole leukemic phenotype. We hypothesized that some ACA not detected by conventional techniques may be informative of the onset of APL. We performed the high-resolution SNP array (SNP-A 6.0 (Affymetrix in 48 patients diagnosed with APL on matched diagnosis and remission sample. Forty-six abnormalities were found as an acquired event in 23 patients (48%: 22 duplications, 23 deletions and 1 Copy-Neutral Loss of Heterozygocity (CN-LOH, being a duplication of 8(q24 (23% and a deletion of 7(q33-qter (6% the most frequent copy-number abnormalities (CNA. Four patients (8% showed CNAs adjacent to the breakpoints of the translocation. We compared our results with other APL series and found that, except for dup(8q24 and del(7q33-qter, ACA were infrequent (≤3% but most of them recurrent (70%. Interestingly, having CNA or FLT3 mutation were mutually exclusive events. Neither the number of CNA, nor any specific CNA was associated significantly with prognosis. This study has delineated recurrent abnormalities in addition to t(15;17 that may act as secondary events and could explain leukemogenesis in up to 40% of APL cases with no ACA by conventional cytogenetics.

  10. Next generation genome-wide association tool: Design and coverage of a high-throughput European-optimized SNP array

    Science.gov (United States)

    Hoffmann, Thomas J.; Kvale, Mark N.; Hesselson, Stephanie E.; Zhan, Yiping; Aquino, Christine; Cao, Yang; Cawley, Simon; Chung, Elaine; Connell, Sheryl; Eshragh, Jasmin; Ewing, Marcia; Gollub, Jeremy; Henderson, Mary; Hubbell, Earl; Iribarren, Carlos; Kaufman, Jay; Lao, Richard Z.; Lu, Yontao; Ludwig, Dana; Mathauda, Gurpreet K.; McGuire, William; Mei, Gangwu; Miles, Sunita; Purdy, Matthew M.; Quesenberry, Charles; Ranatunga, Dilrini; Rowell, Sarah; Sadler, Marianne; Shapero, Michael H.; Shen, Ling; Shenoy, Tanushree R.; Smethurst, David; Van den Eeden, Stephen K.; Walter, Larry; Wan, Eunice; Wearley, Reid; Webster, Teresa; Wen, Christopher C.; Weng, Li; Whitmer, Rachel A.; Williams, Alan; Wong, Simon C.; Zau, Chia; Finn, Andrea; Schaefer, Catherine; Kwok, Pui-Yan; Risch, Neil

    2011-01-01

    The success of genome-wide association studies has paralleled the development of efficient genotyping technologies. We describe the development of a next-generation microarray based on the new highly-efficient Affymetrix Axiom genotyping technology that we are using to genotype individuals of European ancestry from the Kaiser Permanente Research Program on Genes, Environment and Health (RPGEH). The array contains 674,517 SNPs, and provides excellent genome-wide as well as gene-based and candidate-SNP coverage. Coverage was calculated using an approach based on imputation and cross validation. Preliminary results for the first 80,301 saliva-derived DNA samples from the RPGEH demonstrate very high quality genotypes, with sample success rates above 94% and over 98% of successful samples having SNP call rates exceeding 98%. At steady state, we have produced 462 million genotypes per week for each Axiom system. The new array provides a valuable addition to the repertoire of tools for large scale genome-wide association studies. PMID:21565264

  11. Chirped microlens arrays for diode laser circularization and beam expansion

    Science.gov (United States)

    Schreiber, Peter; Dannberg, Peter; Hoefer, Bernd; Beckert, Erik

    2005-08-01

    Single-mode diode lasers are well-established light sources for a huge number of applications but suffer from astigmatism, beam ellipticity and large manufacturing tolerances of beam parameters. To compensate for these shortcomings, various approaches like anamorphic prism pairs and cylindrical telescopes for circularization as well as variable beam expanders based on zoomed telescopes for precise adjustment of output beam parameters have been employed in the past. The presented new approach for both beam circularization and expansion is based on the use of microlens arrays with chirped focal length: Selection of lenslets of crossed cylindrical microlens arrays as part of an anamorphic telescope enables circularization, astigmatism correction and divergence tolerance compensation of diode lasers simultaneously. Another promising application of chirped spherical lens array telescopes is stepwise variable beam expansion for circular laser beams of fiber or solid-state lasers. In this article we describe design and manufacturing of beam shaping systems with chirped microlens arrays fabricated by polymer-on-glass replication of reflow lenses. A miniaturized diode laser module with beam circularization and astigmatism correction assembled on a structured ceramics motherboard and a modulated RGB laser-source for photofinishing applications equipped with both cylindrical and spherical chirped lens arrays demonstrate the feasibility of the proposed system design approach.

  12. UAVSAR Phased Array Aperture

    Science.gov (United States)

    Chamberlain, Neil; Zawadzki, Mark; Sadowy, Greg; Oakes, Eric; Brown, Kyle; Hodges, Richard

    2009-01-01

    This paper describes the development of a patch antenna array for an L-band repeat-pass interferometric synthetic aperture radar (InSAR) instrument that is to be flown on an unmanned aerial vehicle (UAV). The antenna operates at a center frequency of 1.2575 GHz and with a bandwidth of 80 MHz, consistent with a number of radar instruments that JPL has previously flown. The antenna is designed to radiate orthogonal linear polarizations in order to facilitate fully-polarimetric measurements. Beam-pointing requirements for repeat-pass SAR interferometry necessitate electronic scanning in azimuth over a range of -20degrees in order to compensate for aircraft yaw. Beam-steering is accomplished by transmit/receive (T/R) modules and a beamforming network implemented in a stripline circuit board. This paper, while providing an overview of phased array architecture, focuses on the electromagnetic design of the antenna tiles and associated interconnects. An important aspect of the design of this antenna is that it has an amplitude taper of 10dB in the elevation direction. This is to reduce multipath reflections from the wing that would otherwise be detrimental to interferometric radar measurements. This taper is provided by coupling networks in the interconnect circuits as opposed to attenuating the output of the T/R modules. Details are given of material choices and fabrication techniques that meet the demanding environmental conditions that the antenna must operate in. Predicted array performance is reported in terms of co-polarized and crosspolarized far-field antenna patterns, and also in terms of active reflection coefficient.

  13. BOOK REVIEW: The Artful Universe Expanded

    Science.gov (United States)

    Bassett, B. A.

    2005-07-01

    The cosmos is an awfully big place and there is no better guide to its vast expanse and fascinating nooks and crannies than John Barrow. A professor of mathematical sciences at Cambridge University, Barrow embodies that rare combination of highly polished writer and expert scientist. His deft touch brings together the disparate threads of human knowledge and weaves them into a tapestry as rich and interesting for the expert as it is for the layperson. The Artful Universe Expanded is an updated edition of this popular book first published in 1995. It explores the deeply profound manner in which natural law and the nature of the cosmos have moulded and shaped us, our cultures and the very form of our arts and music—a new type of `cosmic' anthropology. The main themes Barrow chooses for revealing this new anthropology are the subjects of evolution, the size of things, the heavens and the nature of music. The book is a large, eclectic repository of knowledge often unavailable to the layperson,\\endcolumn hidden in esoteric libraries around the world. It rivals The Da Vinci Code for entertainment value and insights, but this time it is Nature’s code that is revealed. It is rare indeed to find common threads drawn through topics as diverse as The Beetles, Bach and Beethoven or between Jackson Pollock, the Aztecs, Kant, Picasso, Byzantine mosaics, uranium-235 and the helix nebula. Barrow unerringly binds them together, presenting them in a stimulating, conversational style that belies the amount of time that must have gone into researching this book. Dip into it at random, or read it from cover to cover, but do read it. The Artful Universe Expanded is an entertaining antidote to the oft-lamented pressures to know more and more about less and less and the apparently inexorable march of specialization. On reading this book one can, for a short time at least, hold in one’s mind a vision that unifies science, art and culture and glimpse a universal tapestry of great

  14. Weak Algebraic Monge Arrays

    OpenAIRE

    Rudolf, Rüdiger; Fortin, Dominique

    1995-01-01

    An $n\\times n$ matrix $C$ is called a {\\em weak Monge\\/} matrix iff $c_{ii}+c_{rs}\\le c_{is}+c_{ri}$ for all $1\\le i\\le r,s\\le n$. It is well known that the classical linear assignment problem is optimally solved by the identity permutation if the underlying cost-matrix fulfills the weak Monge property. In this paper we introduce higher dimensional weak Monge arrays and prove that higher dimensional axial assignment problems can be solved efficiently if the cost-structure is a higher dimensio...

  15. The Square Kilometre Array

    CERN Document Server

    Rawlings, Steve

    2011-01-01

    We review the current status of the Square Kilometre Array (SKA) by outlining the science drivers for its Phase-1 (SKA1) and setting out the timeline for the key decisions and milestones on the way to the planned start of its construction in 2016. We explain how Phase-2 SKA (SKA2) will transform the research scope of the SKA infrastructure, placing it amongst the great astronomical observatories and survey instruments of the future, and opening up new areas of discovery, many beyond the confines of conventional astronomy.

  16. A solar array module fabrication process for HALE solar electric UAVs

    Energy Technology Data Exchange (ETDEWEB)

    Carey, P.G.; Aceves, R.C.; Colella, N.J.; Thompson, J.B.; Williams, K.A.

    1993-12-01

    We describe a fabrication process to manufacture high power to weight ratio flexible solar array modules for use on high altitude long endurance (HALE) solar electric unmanned air vehicles (UAVs). A span-loaded flying wing vehicle, known as the RAPTOR Pathfinder, is being employed as a flying test bed to expand the envelope of solar powered flight to high altitudes. It requires multiple light weight flexible solar array modules able to endure adverse environmental conditions. At high altitudes the solar UV flux is significantly enhanced relative to sea level, and extreme thermal variations occur. Our process involves first electrically interconnecting solar cells into an array followed by laminating them between top and bottom laminated layers into a solar array module. After careful evaluation of candidate polymers, fluoropolymer materials have been selected as the array laminate layers because of their inherent abilities to withstand the hostile conditions imposed by the environment.

  17. Expanding the conceptual toolkit of organ gifting.

    Science.gov (United States)

    M Shaw, Rhonda

    2015-07-01

    In jurisdictions where the sale of body tissue and organs is illegal, organ transplantation is often spoken of as a gift of life. In the social sciences and bioethics this concept has been subject to critique over the course of the last two decades for failing to reflect the complexities of organ and tissue exchange. I suggest that a new ethical model of organ donation and transplantation is needed to capture the range of experiences in this domain. The proposed model is both analytical and empirically oriented, and draws on research findings linking a series of qualitative sociological studies undertaken in New Zealand between 2007 and 2013. The studies were based on document analysis, field notes and 127 semi-structured in-depth interviews with people from different cultural and constituent groups directly involved in organ transfer processes. The aim of the article is to contribute to sociological knowledge about organ exchange and to expand the conceptual toolkit of organ donation to include the unconditional gift, the gift relation, gift exchange, body project, and body work. The rationale for the proposed model is to provide an explanatory framework for organ donors and transplant recipients and to assist the development of ethical guidelines and health policy discourse. PMID:25728628

  18. Is Space Really Expanding? A Counterexample

    Science.gov (United States)

    Chodorowski, Michał J.

    2007-03-01

    In all Friedman models, the cosmological redshift is widely interpreted as a consequence of the general-relativistic phenomenon of expansion of space. Other commonly believed consequences of this phenomenon are superluminal recession velocities of distant galaxies, and the distance to the particle horizon greater than ct (where t is the age of the Universe), in apparent conflict with special relativity. Here, we study a particular Friedman model: empty universe. This model exhibits both cosmological redshift, superluminal velocities and infinite distance to the horizon. However, we show that the cosmological redshift is there simply a relativistic Doppler shift. Moreover, apparently superluminal velocities and ‘acausal’ distance to the horizon are in fact a direct consequence of special-relativistic phenomenon of time dilation, as well as of the adopted definition of distance in cosmology. There is no conflict with special relativity, whatsoever. In particular, inertial recession velocities are subluminal. Since in the real Universe, sufficiently distant galaxies recede with relativistic velocities, these special-relativistic effects must be at least partly responsible for the cosmological redshift and the aforementioned ‘superluminalities’, commonly attributed to the expansion of space. Let us finish with a question resembling a Buddhism-Zen ‘koan’: in an empty universe, what is expanding?

  19. The expanding universe of prion diseases.

    Directory of Open Access Journals (Sweden)

    Joel C Watts

    2006-03-01

    Full Text Available Prions cause fatal and transmissible neurodegenerative disease. These etiological infectious agents are formed in greater part from a misfolded cell-surface protein called PrP(C. Several mammalian species are affected by the diseases, and in the case of "mad cow disease" (BSE the agent has a tropism for humans, with negative consequences for agribusiness and public health. Unfortunately, the known universe of prion diseases is expanding. At least four novel prion diseases--including human diseases variant Creutzfeldt-Jakob disease (vCJD and sporadic fatal insomnia (sFI, bovine amyloidotic spongiform encephalopathy (BASE, and Nor98 of sheep--have been identified in the last ten years, and chronic wasting disease (CWD of North American deer (Odocoileus Specis and Rocky Mountain elk (Cervus elaphus nelsoni is undergoing a dramatic spread across North America. While amplification (BSE and dissemination (CWD, commercial sourcing of cervids from the wild and movement of farmed elk can be attributed to human activity, the origins of emergent prion diseases cannot always be laid at the door of humankind. Instead, the continued appearance of new outbreaks in the form of "sporadic" disease may be an inevitable outcome in a situation where the replicating pathogen is host-encoded.

  20. The expanding universe of prion diseases.

    Directory of Open Access Journals (Sweden)

    2006-03-01

    Full Text Available Prions cause fatal and transmissible neurodegenerative disease. These etiological infectious agents are formed in greater part from a misfolded cell-surface protein called PrP(C. Several mammalian species are affected by the diseases, and in the case of "mad cow disease" (BSE the agent has a tropism for humans, with negative consequences for agribusiness and public health. Unfortunately, the known universe of prion diseases is expanding. At least four novel prion diseases-including human diseases variant Creutzfeldt-Jakob disease (vCJD and sporadic fatal insomnia (sFI, bovine amyloidotic spongiform encephalopathy (BASE, and Nor98 of sheep-have been identified in the last ten years, and chronic wasting disease (CWD of North American deer (Odocoileus Specis and Rocky Mountain elk (Cervus elaphus nelsoni is undergoing a dramatic spread across North America. While amplification (BSE and dissemination (CWD, commercial sourcing of cervids from the wild and movement of farmed elk can be attributed to human activity, the origins of emergent prion diseases cannot always be laid at the door of humankind. Instead, the continued appearance of new outbreaks in the form of "sporadic" disease may be an inevitable outcome in a situation where the replicating pathogen is host-encoded.

  1. Tachyonic Resonance Preheating in Expanding Universe

    CERN Document Server

    Abolhasani, Ali Akbar; Sheikh-Jabbari, M M

    2009-01-01

    In this paper the tachyonic resonance preheating generated from the bosonic trilinear $\\phi\\chi^2$ interactions in an expanding Universe is studied. In $\\lambda\\phi^4/4$ inflationary model the trilinear interaction, in contrast to the four-legs $\\phi^2\\chi^2$, breaks the conformal symmetry explicitly and the resonant source term becomes non-periodic, making the Floquet theorem inapplicable. We find that the occupation number of the produced $\\chi$-particles has a non-linear exponential growth with exponent $\\sim x^{3/2}$, where $x$ is the conformal time. This should be contrasted with preheating from a periodic resonant source, arising for example from the four-legs $\\phi^2\\chi^2$ interaction, where the occupation number has a linear exponential growth. We present an analytic method to compute the interference term coming from phases accumulated in non-tachyonic scattering regions and show that the effects of the interference term causes ripples on $x^{3/2}$ curve, a result which is confirmed by numerical ana...

  2. Expanded polylactide bead foaming - A new technology

    Science.gov (United States)

    Nofar, M.; Ameli, A.; Park, C. B.

    2015-05-01

    Bead foaming technology with double crystal melting peak structure has been recognized as a promising method to produce low-density foams with complex geometries. During the molding stage of the bead foams, the double peak structure generates a strong bead-to-bead sintering and maintains the overall foam structure. During recent years, polylactide (PLA) bead foaming has been of the great interest of researchers due to its origin from renewable resources and biodegradability. However, due to the PLA's low melt strength and slow crystallization kinetics, the attempts have been limited to the manufacturing methods used for expanded polystyrene. In this study, for the first time, we developed microcellular PLA bead foams with double crystal melting peak structure. Microcellular PLA bead foams were produced with expansion ratios and average cell sizes ranging from 3 to 30-times and 350 nm to 15 µm, respectively. The generated high melting temperature crystals during the saturation significantly affected the expansion ratio and cell density of the PLA bead foams by enhancing the PLA's poor melt strength and promoting heterogeneous cell nucleation around the crystals.

  3. Is Space Really Expanding? A Counterexample

    International Nuclear Information System (INIS)

    In all Friedman models, the cosmological redshift is widely interpreted as a consequence of the general-relativistic phenomenon of expansion of space. Other commonly believed consequences of this phenomenon are superluminal recession velocities of distant galaxies, and the distance to the particle horizon greater than c t (where t is the age of the Universe), in apparent conflict with special relativity. Here, we study a particular Friedman model: empty universe. This model exhibits both cosmological redshift, superluminal velocities and infinite distance to the horizon. However, we show that the cosmological redshift is there simply a relativistic Doppler shift. Moreover, apparently superluminal velocities and ' acausal ' distance to the horizon are in fact a direct consequence of special-relativistic phenomenon of time dilation, as well as of the adopted definition of distance in cosmology. There is no conflict with special relativity, whatsoever. In particular, inertial recession velocities are subluminal. Since in the real Universe, sufficiently distant galaxies recede with relativistic velocities, these special-relativistic effects must be at least partly responsible for the cosmological redshift and the aforementioned ' superluminalities ', commonly attributed to the expansion of space. Let us finish with a question resembling a Buddhism-Zen ' koan ': in an empty universe, what is expanding? (author)

  4. Gravitomagnetic Instabilities in Anisotropically Expanding Fluids

    Science.gov (United States)

    Kleidis, Kostas; Kuiroukidis, Apostolos; Papadopoulos, Demetrios B.; Vlahos, Loukas

    Gravitational instabilities in a magnetized Friedman-Robertson-Walker (FRW) universe, in which the magnetic field was assumed to be too weak to destroy the isotropy of the model, are known and have been studied in the past. Accordingly, it became evident that the external magnetic field disfavors the perturbations' growth, suppressing the corresponding rate by an amount proportional to its strength. However, the spatial isotropy of the FRW universe is not compatible with the presence of large-scale magnetic fields. Therefore, in this paper we use the general-relativistic version of the (linearized) perturbed magnetohydrodynamic equations with and without resistivity, to discuss a generalized Jeans criterion and the potential formation of density condensations within a class of homogeneous and anisotropically expanding, self-gravitating, magnetized fluids in curved space-time. We find that, for a wide variety of anisotropic cosmological models, gravitomagnetic instabilities can lead to subhorizontal, magnetized condensations. In the nonresistive case, the power spectrum of the unstable cosmological perturbations suggests that most of the power is concentrated on large scales (small k), very close to the horizon. On the other hand, in a resistive medium, the critical wave-numbers so obtained, exhibit a delicate dependence on resistivity, resulting in the reduction of the corresponding Jeans lengths to smaller scales (well bellow the horizon) than the nonresistive ones, while increasing the range of cosmological models which admit such an instability.

  5. Gravitational instability in a multicomponent expanding medium

    International Nuclear Information System (INIS)

    Gravitational instability in a medium, consisting of two or more components, in the expanding Universe is considered in the framework of the Newtonian theory. The system of equations for density perturbations is solved in the short-wave and long-wave approximations. It is shown that under the small values of the wave vector k, the conclusion on the existence of at most one unstable mode of density perturbations growth survives. With k fixed, the presence of another component (deltasub(i)) leads to a more rapid growth of perturbations of the component deltasub(j), provided that γsub(i)>γsub(j). In the limiting case of large wave vectors, ordinary sound waves are obtained. The influence of other components starts to tell on the terms of the first order in 1/k in the expansion of the oscillation amplitude in powers of 1/k. This reveals itself in a slower decrease of the amplitude for the considered component (deltasub(i)), provided that γsub(j)>γsub(i)>=4/3

  6. Expandable image compression system: A modular approach

    International Nuclear Information System (INIS)

    The full-frame bit allocation algorithm for radiological image compression developed in the authors' laboratory can achieve compression ratios as high as 30:1. The software development and clinical evaluation of this algorithm has been completed. It involves two stages of operations: a two-dimensional discrete cosine transform and pixel quantization in the transform space with pixel depth kept accountable by a bit allocation table. Their design took an expandable modular approach based on the VME bus system which has a maximum data transfer rate of 48 Mbytes per second and a Motorola 68020 microprocessor as the master controller. The transform modules are based on advanced digital signal processor (DSP) chips microprogrammed to perform fast cosine transforms. Four DSP's built into a single-board transform module can process an 1K x 1K image in 1.7 seconds. Additional transform modules working in parallel can be added if even greater speeds are desired. The flexibility inherent in the microcode extends the capabilities of the system to incorporate images of variable sizes. Their design allows for a maximum image size of 2K x 2K

  7. Expanding the Allowable TRUPACT-II Payload

    International Nuclear Information System (INIS)

    The partnership between the Carlsbad Field Office (CBFO) and the TRU and Mixed Waste Focus Area (TMFA) was rewarded when several long-term projects came to fruition. The Nuclear Regulatory Commission (NRC) removed some of the conservatism in the TRUPACT-II Safety Analysis Report for Packaging (SARP) with their approval of Revision 19. The SARP strictly limits the payload constituents to ensure that hydrogen gas and other flammable volatile organic compounds (VOCs) don't build up to flammable/explosive levels while the transuranic (TRU) waste is sealed in the container during shipment. The CBFO/TMFA development program was based on laboratory experiments with surrogate waste materials, real waste experiments, and theoretical modeling that were used to justify payload expansion. Future work to expand the shipping envelope of the TRUPACT-II focuses on increasing the throughput through the waste certification process and reducing the waste operations costs by removing the need for a repack aging and/or treatment capability or reducing the size of the needed repackaging/treatment capability

  8. Homogeneous cosmology with aggressively expanding civilizations

    Science.gov (United States)

    Olson, S. Jay

    2015-11-01

    In the context of a homogeneous Universe, we note that the appearance of aggressively expanding advanced life is geometrically similar to the process of nucleation and bubble growth in a first-order cosmological phase transition. We exploit this similarity to describe the dynamics of life saturating the Universe on a cosmic scale, adapting the phase transition model to incorporate probability distributions of expansion and resource consumption strategies. Through a series of numerical solutions spanning several orders of magnitude in the input assumption parameters, the resulting cosmological model is used to address basic questions related to the intergalactic spreading of life, dealing with issues such as timescales, observability, competition between strategies, and first-mover advantage. Finally, we examine physical effects on the Universe itself, such as reheating and the backreaction on the evolution of the scale factor, if such life is able to control and convert a significant fraction of the available pressureless matter into radiation. We conclude that the existence of life, if certain advanced technologies are practical, could have a significant influence on the future large-scale evolution of the Universe.

  9. Selecting Sums in Arrays

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Jørgensen, Allan Grønlund

    2008-01-01

    In an array of n numbers each of the \\binomn2+nUnknown control sequence '\\binom' contiguous subarrays define a sum. In this paper we focus on algorithms for selecting and reporting maximal sums from an array of numbers. First, we consider the problem of reporting k subarrays inducing the k largest...... sums among all subarrays of length at least l and at most u. For this problem we design an optimal O(n + k) time algorithm. Secondly, we consider the problem of selecting a subarray storing the k’th largest sum. For this problem we prove a time bound of Θ(n · max {1,log(k/n)}) by describing an...... algorithm with this running time and by proving a matching lower bound. Finally, we combine the ideas and obtain an O(n· max {1,log(k/n)}) time algorithm that selects a subarray storing the k’th largest sum among all subarrays of length at least l and at most u....

  10. Expanders for micro-CHP systems with organic Rankine cycle

    International Nuclear Information System (INIS)

    The continual increases in global energy demand and greenhouse gas emissions call for more and more utilisation of sustainable energy sources, such as solar energy, biomass energy, and waste heat. Solar thermal energy, the heat of biomass combustion and waste heat may be used to drive a combined heat and power (CHP) system. In recent years, several micro-CHP systems with organic Rankine cycle (ORC) suitable for domestic applications (1-10 kWe) driven by solar thermal, biomass-fired boilers and waste heat resources have been investigated. These ORC-based micro-CHP systems have lower operation pressures and temperatures compared to conventional steam-Rankine cycle CHP systems and hence safer for household applications. However, the lack of commercially available expanders applicable to ORC-based micro-CHP systems has hindered the development of these novel CHP systems. This paper summarizes the findings of the market research for the expanders and discusses the selection and choices of the expanders for ORC-based micro-CHP systems. The working principles and the characteristics of several kinds of expanders, including turbine expanders (i.e., turboexpander), screw expanders, scroll expanders and vane expanders, are introduced and evaluated. - Highlights: → Expanders are vital to ORC-based micro-CHP but not yet commercially available. → Selection and choices of the expanders for 1-10 kWe micro-CHP are discussed. → Vane expanders modified from vane-type air motors have been applied by the authors. → Scroll expanders and vane expanders are likely the good choices for 1-10 kWe micro-CHP.

  11. Electromagnetically Clean Solar Arrays

    Science.gov (United States)

    Stem, Theodore G.; Kenniston, Anthony E.

    2008-01-01

    The term 'electromagnetically clean solar array' ('EMCSA') refers to a panel that contains a planar array of solar photovoltaic cells and that, in comparison with a functionally equivalent solar-array panel of a type heretofore used on spacecraft, (1) exhibits less electromagnetic interferences to and from other nearby electrical and electronic equipment and (2) can be manufactured at lower cost. The reduction of electromagnetic interferences is effected through a combination of (1) electrically conductive, electrically grounded shielding and (2) reduction of areas of current loops (in order to reduce magnetic moments). The reduction of cost is effected by designing the array to be fabricated as a more nearly unitary structure, using fewer components and fewer process steps. Although EMCSAs were conceived primarily for use on spacecraft they are also potentially advantageous for terrestrial applications in which there are requirements to limit electromagnetic interference. In a conventional solar panel of the type meant to be supplanted by an EMCSA panel, the wiring is normally located on the back side, separated from the cells, thereby giving rise to current loops having significant areas and, consequently, significant magnetic moments. Current-loop geometries are chosen in an effort to balance opposing magnetic moments to limit far-0field magnetic interactions, but the relatively large distances separating current loops makes full cancellation of magnetic fields problematic. The panel is assembled from bare photovoltaic cells by means of multiple sensitive process steps that contribute significantly to cost, especially if electomagnetic cleanliness is desired. The steps include applying a cover glass and electrical-interconnect-cell (CIC) sub-assemble, connecting the CIC subassemblies into strings of series-connected cells, laying down and adhesively bonding the strings onto a panel structure that has been made in a separate multi-step process, and mounting the

  12. Electrode array for neural stimulation

    Energy Technology Data Exchange (ETDEWEB)

    Wessendorf, Kurt O. (Albuquerque, NM); Okandan, Murat (Edgewood, NM); Stein, David J. (Albuquerque, NM); Yang, Pin (Albuquerque, NM); Cesarano, III, Joseph (Albuquerque, NM); Dellinger, Jennifer (Albuquerque, NM)

    2011-08-16

    An electrode array for neural stimulation is disclosed which has particular applications for use in a retinal prosthesis. The electrode array can be formed as a hermetically-sealed two-part ceramic package which includes an electronic circuit such as a demultiplexer circuit encapsulated therein. A relatively large number (up to 1000 or more) of individually-addressable electrodes are provided on a curved surface of a ceramic base portion the electrode array, while a much smaller number of electrical connections are provided on a ceramic lid of the electrode array. The base and lid can be attached using a metal-to-metal seal formed by laser brazing. Electrical connections to the electrode array can be provided by a flexible ribbon cable which can also be used to secure the electrode array in place.

  13. The Murchison Widefield Array Correlator

    OpenAIRE

    Ord, S. M.; Crosse, B.; Emrich, D.; Pallot, D.; Wayth, R. B.; Clark, M. A.; Tremblay, S. E.; Arcus, W.; Barnes, D; Bell, M.; Bernardi, G.; Bhat, N. D. R.; Bowman, J.D.; Briggs, F.; Bunton, J. D.

    2014-01-01

    The Murchison Widefield Array (MWA) is a Square Kilometre Array (SKA) Precursor. The telescope is located at the Murchison Radio--astronomy Observatory (MRO) in Western Australia (WA). The MWA consists of 4096 dipoles arranged into 128 dual polarisation aperture arrays forming a connected element interferometer that cross-correlates signals from all 256 inputs. A hybrid approach to the correlation task is employed, with some processing stages being performed by bespoke hardware, based on Fiel...

  14. Aligators for Arrays (Tool Paper)

    Science.gov (United States)

    Henzinger, Thomas A.; Hottelier, Thibaud; Kovács, Laura; Rybalchenko, Andrey

    This paper presents Aligators, a tool for the generation of universally quantified array invariants. Aligators leverages recurrence solving and algebraic techniques to carry out inductive reasoning over array content. The Aligators' loop extraction module allows treatment of multi-path loops by exploiting their commutativity and serializability properties. Our experience in applying Aligators on a collection of loops from open source software projects indicates the applicability of recurrence and algebraic solving techniques for reasoning about arrays.

  15. Combinatorial aspects of covering arrays

    Directory of Open Access Journals (Sweden)

    Charles J. Colbourn

    2004-11-01

    Full Text Available Covering arrays generalize orthogonal arrays by requiring that t -tuples be covered, but not requiring that the appearance of t -tuples be balanced.Their uses in screening experiments has found application in software testing, hardware testing, and a variety of fields in which interactions among factors are to be identified. Here a combinatorial view of covering arrays is adopted, encompassing basic bounds, direct constructions, recursive constructions, algorithmic methods, and applications.

  16. Electrodynamic Arrays Having Nanomaterial Electrodes

    Science.gov (United States)

    Trigwell, Steven (Inventor); Biris, Alexandru S. (Inventor); Calle, Carlos I. (Inventor)

    2013-01-01

    An electrodynamic array of conductive nanomaterial electrodes and a method of making such an electrodynamic array. In one embodiment, a liquid solution containing nanomaterials is deposited as an array of conductive electrodes on a substrate, including rigid or flexible substrates such as fabrics, and opaque or transparent substrates. The nanomaterial electrodes may also be grown in situ. The nanomaterials may include carbon nanomaterials, other organic or inorganic nanomaterials or mixtures.

  17. Expanding on Successful Concepts, Models, and Organization

    Energy Technology Data Exchange (ETDEWEB)

    Teeguarden, Justin G.; Tan, Yu-Mei; Edwards, Stephen; Leonard, Jeremy A.; Anderson, Kim; Corley, Richard A.; Kile, Molly L.; Massey Simonich, Staci L.; Stone, David; Tanguay, Robert; Waters, Katrina M.; Harper, Stacey; Williams, David E.

    2016-08-10

    In her letter to the editor1 regarding our recent Feature Article “Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework” 2, Dr. von Göetz expressed several concerns about terminology, and the perception that we propose the replacement of successful approaches and models for exposure assessment with a concept. We are glad to have the opportunity to address these issues here. If the goal of the AEP framework was to replace existing exposure models or databases for organizing exposure data with a concept, we would share Dr. von Göetz concerns. Instead, the outcome we promote is broader use of an organizational framework for exposure science. The framework would support improved generation, organization, and interpretation of data as well as modeling and prediction, not replacement of models. The field of toxicology has seen the benefits of wide use of one or more organizational frameworks (e.g., mode and mechanism of action, adverse outcome pathway). These frameworks influence how experiments are designed, data are collected, curated, stored and interpreted and ultimately how data are used in risk assessment. Exposure science is poised to similarly benefit from broader use of a parallel organizational framework, which Dr. von Göetz correctly points out, is currently used in the exposure modeling community. In our view, the concepts used so effectively in the exposure modeling community, expanded upon in the AEP framework, could see wider adoption by the field as a whole. The value of such a framework was recognized by the National Academy of Sciences.3 Replacement of models, databases, or any application with the AEP framework was not proposed in our article. The positive role broader more consistent use of such a framework might have in enabling and advancing “general activities such as data acquisition, organization…,” and exposure modeling was discussed

  18. Developing an Inflatable Solar Array

    OpenAIRE

    Malone, Patrick; Crawford, Larry; Williams, Geoffrey,

    1993-01-01

    L'Garde is developing a light weight deployable solar array wing in the 200-1000 watt range, on the Inflatable Torus Solar Array Technology Demonstration (ITSAT Demo) Project. The power density goal is 90-100 W/Kg for a 200 W wing, including structure and deployment mechanisms. In Phase 1, a proof of concept torus and array was constructed and deployed in the laboratory. A revised Phase 2 Torus and Array are now being fabricated. Phase 3 will be a space flight test. The current design uses cr...

  19. Gonadotropin releasing hormone agonists: Expanding vistas

    Directory of Open Access Journals (Sweden)

    Navneet Magon

    2011-01-01

    Full Text Available Gonadotropin-releasing hormone (GnRH agonists are derived from native GnRH by amino acid substitution which yields the agonist resistant to degradation and increases its half-life. The hypogonadotropic hypogonadal state produced by GnRH agonists has been often dubbed as "pseudomenopause" or "medical oophorectomy," which are both misnomers. GnRH analogues (GnRH-a work by temporarily "switching off" the ovaries. Ovaries can be "switched off" for the therapy and therapeutic trial of many conditions which include but are not limited to subfertility, endometriosis, adenomyosis, uterine leiomyomas, precocious puberty, premenstrual dysphoric disorder, chronic pelvic pain, or the prevention of menstrual bleeding in special clinical situations. Rapidly expanding vistas of usage of GnRH agonists encompass use in sex reassignment of male to female transsexuals, management of final height in cases of congenital adrenal hyperplasia, and preserving ovarian function in women undergoing cytotoxic chemotherapy. Hypogonadic side effects caused by the use of GnRH agonists can be tackled with use of "add-back" therapy. Goserelin, leuprolide, and nafarelin are commonly used in clinical practice. GnRH-a have provided us a powerful therapeutic approach to the treatment of numerous conditions in reproductive medicine. Recent synthesis of GnRH antagonists with a better tolerability profile may open new avenues for both research and clinical applications. All stakeholders who are partners in women′s healthcare need to join hands to spread awareness so that these drugs can be used to realize their full potential.

  20. Equations of motion in an Expanding Universe

    Science.gov (United States)

    Kopeikin, Sergei M.; Petrov, Alexander N.

    2015-06-01

    We make use of an effective field-theoretical approach to derive post-Newtonian equations of motion of hydrodynamical inhomogeneities in cosmology. The matter Lagrangian for the perturbed cosmological model includes dark matter, dark energy, and ordinary baryonic matter. The Lagrangian is expanded in an asymptotic Taylor series around a Friedmann-Lemaître-Robertson-Walker background. The small parameter of the decomposition is the magnitude of the metric tensor perturbation. Each term of the expansion series is gauge-invariant and all of them together form a basis for the successive post-Newtonian approximations around the background metric. The approximation scheme is covariant and the asymptotic nature of the Lagrangian decomposition does not require the post-Newtonian perturbations to be small though computationally it works the most effectively when the perturbed metric is close enough to the background metric. Temporal evolution of the background metric is governed by dark matter and dark energy and we associate the large-scale inhomogeneities of matter as those generated by the primordial cosmological perturbations in these two components with δρ/ρ ≤ 1. The small scale inhomogeneities are generated by the baryonic matter which is considered as a bare perturbation of the background gravitational field, dark matter and energy. Mathematically, the large scale structure inhomogeneities are given by the homogeneous solution of the post-Newtonian equations while the small scale inhomogeneities are described by a particular solution of these equations with the stress-energy tensor of the baryonic matter that admits δρ/ρ ≫ 1. We explicitly work out the field equations of the first post-Newtonian approximation in cosmology and derive the post-Newtonian equations of motion of the large and small scale inhomogeneities which generalize the covariant law of conservation of stress-energy-momentum tensor of matter in asymptotically-flat spacetime.

  1. Expanding Awareness of Docosahexaenoic Acid during Pregnancy

    Directory of Open Access Journals (Sweden)

    Barbara J. Meyer

    2013-04-01

    Full Text Available Pregnant women do not currently meet the consensus recommendation for docosahexaenoic acid (DHA (≥200 mg/day. Pregnant women in Australia are not receiving information on the importance of DHA during pregnancy. DHA pregnancy education materials were developed using current scientific literature, and tested for readability and design aesthetics. The study aimed to evaluate their usefulness, the desire for pregnant women to receive these materials and whether a larger separate study (using a control group is warranted to evaluate the influence the materials may have on increasing DHA consumption in pregnant women in Australia. Pregnant women (N = 118 were recruited at antenatal clinics at two NSW hospitals. Participants completed a 16-item questionnaire and DHA educational materials (pamphlet and shopping card were provided. Participants were contacted via phone two weeks later and completed the second questionnaire (25-item, N = 74. Statistics were conducted in SPSS and qualitative data were analysed to identify common themes. Ninety three percent of women found the materials useful, with the main reason being it expanded their knowledge of DHA food sources. Only 34% of women had received prior information on DHA, yet 68% said they would like to receive information. Due to the small sample size and lack of a control group, this small study cannot provide a cause and effect relationship between the materials and nutrition related behaviours or knowledge, however the results indicate a potential positive influence towards increased fish consumption and awareness of DHA containing foods. This suggests a larger study, with a control group is warranted to identify the impact such materials could have on Australian pregnant women.

  2. Exposing medical students to expanding populations

    Directory of Open Access Journals (Sweden)

    Lindenthal JJ

    2015-03-01

    Full Text Available JJ Lindenthal,1,2 JA DeLisa,3 GF Heinrich,4 WS Calderón Gerstein,5 1Department of Psychiatry, Institute for the Public Understanding of Health and Medicine, 2Department of Physical Medicine and Rehabilitation, New Jersey Medical School, Rutgers University, Newark, NJ, USA; 3Department of Orthopedics and Rehabilitation, University of New Mexico Health Science Center, Albuquerque, NM, USA; 4Department of Preventive Medicine and Community Health, New Jersey Medical School, Rutgers University, Newark, NJ, USA; 5Hospital Nacional Ramiro Prialé, EsSalud, Huancayo, Peru Abstract: Physicians are required to advocate for and counsel patients based on the best science and the interests of the individual while avoiding discrimination, ensuring equal access to health and mental services. Nonetheless, the communication gap between physician and patients has long been observed. To this end, the Institute for the Public Understanding of Health and Medicine of the Rutgers University New Jersey Medical School has expanded its efforts. This report describes two new programs: a legacy lecture series for medical students and an international “experience”, in Huancayo, Peru, for medical students and faculty. The MiniMed outreach program, now in its ninth year and first described in this journal in 2012, was designed to empower the powerless to communicate more effectively with clinicians, thus improving both the effectiveness of the physician–patient relationship and health care outcomes. The approach of the two new programs and their effects on patients, particularly the underserved, and medical students and faculty, are outlined in the following article. Keywords: MiniMed program, equal access, underserved populations, Newark Renaissance House, Kintock Group, role modeling 

  3. PROFAM expands Mexican family planning clinics.

    Science.gov (United States)

    1983-01-01

    Mexico's private, nonprofit social marketing company, known as PROFAM, intends to expand its family planning clinics to marginal urban areas. The clinics are part of PROFAM's push to diversify social marketing outlets for contraceptive products and other birth control methods. PROFAM expects to establish 3 new clinics, possibly including a pregnancy test laboratory, a small 1-doctor clinic, and a large clinic housing an operating room. 1 clinic will be located outside the Mexico City area, the program's traditional boundaries. The company currently runs 2 small clinics and a pregnancy testing laboratory in Ciudad Netzahualcoyti, a community of 3.5 million on Mexico City's outskirts. PROFAM recently obtaine d government approval to sell condoms in food stores, which should increase distribtuion and sales. Currently, the company sells over 1 million high quality, lubricated condoms each month, accounting for over half of the Mexican market. Distribution covers 85% of the country's drugstore. Program setbacks occurred in 1981, when the Mexican government cancelled PROFAM's sales permits for all contraceptive products except condoms. Cancelled products included an oral contraceptive and 3 vaginal spermicides. These 4 products had provided nearly 100,000 couple years of protection in 1979 and an estimated 120,000 CYP 1980. During 1979 and 1980, condoms provided about 27,000 and 60,000 CYP, respectively. PROFAM had relied heavily on the pill and spermicides because its early studies showed condoms had a negative image in Mexico, due largely to the product's association with extramarital affairs. To counter this, PROFAM launched a widespread, free product sampling program in 1979, along with a continuing educational and advertising drive. Subsequent consumer surveys revealed a marked increase in product acceptance, with PROFAM's condom becoming the most widely known brand available in Mexico. PMID:12267250

  4. Meta-Analysis Combines Affymetrix Microarray Results Across Laboratories

    OpenAIRE

    Doerge, R. W.; John R. Stevens

    2005-01-01

    With microarray technology becoming more prevalent in recent years, it is now common for several laboratories to employ the same microarray technology to identify differentially expressed genes that are related to the same phenomenon in the same species. Although experimental specifics may be similar, each laboratory will typically produce a slightly different list of statistically significant genes, which calls into question the validity of each gene list (i.e. which list is best). A statist...

  5. Array-A-Lizer: A serial DNA microarray quality analyzer

    Directory of Open Access Journals (Sweden)

    Matthiessen Mads

    2004-02-01

    Full Text Available Abstract Background The proliferate nature of DNA microarray results have made it necessary to implement a uniform and quick quality control of experimental results to ensure the consistency of data across multiple experiments prior to actual data analysis. Results Array-A-Lizer is a small and convenient stand-alone tool providing the necessary initial analysis of hybridization quality of an unlimited number of microarray experiments. The experiments are analyzed for even hybridization across the slide and between fluorescent dyes in two-color experiments in spotted DNA microarrays. Conclusions Array-A-Lizer allows the expedient determination of the quality of multiple DNA microarray experiments allowing for a rapid initial screening of results before progressing to further data analysis. Array-A-Lizer is directed towards speed and ease-of-use allowing both the expert and non-expert microarray researcher to rapidly assess the quality of multiple microarray hybridizations. Array-A-Lizer is available from the Internet as both source code and as a binary installation package.

  6. Cascading Constrained 2-D Arrays using Periodic Merging Arrays

    DEFF Research Database (Denmark)

    Forchhammer, Søren; Laursen, Torben Vaarby

    2003-01-01

    We consider a method for designing 2-D constrained codes by cascading finite width arrays using predefined finite width periodic merging arrays. This provides a constructive lower bound on the capacity of the 2-D constrained code. Examples include symmetric RLL and density constrained codes....... Numerical results for the capacities are presented....

  7. Solitons in optomechanical arrays.

    Science.gov (United States)

    Gan, Jing-Hui; Xiong, Hao; Si, Liu-Gang; Lü, Xin-You; Wu, Ying

    2016-06-15

    We show that optical solitons can be obtained with a one-dimensional optomechanical array that consists of a chain of periodically spaced identical optomechanical systems. Unlike conventional optical solitons, which originate from nonlinear polarization, the optical soliton here stems from a new mechanism, namely, phonon-photon interaction. Under proper conditions, the phonon-photon induced nonlinearity that refers to the optomechanical nonlinearity will exactly compensate the dispersion caused by photon hopping of adjacent optomechanical systems. Moreover, the solitons are capable of exhibiting very low group velocity, depending on the photon hopping rate, which may lead to many important applications, including all-optical switches and on-chip optical architecture. This work may extend the range of optomechanics and nonlinear optics and provide a new field to study soliton theory and develop corresponding applications. PMID:27304261

  8. GERmanium detector array, GERDA

    International Nuclear Information System (INIS)

    The GERmanium Detector Array, GERDA, is designed to search for 'neutrinoless double beta decay' (0ν2β) in 76Ge. The high-purity segmented Ge detectors will be directly submerged and operated in liquid N2 or Ar. The measurement of the half-life time of 0ν2β decay will provide information about the absolute neutrino mass scale and indirectly, the hierarchy. The design goal of GERDA is to reach a sensitivity of 0.2 eV on the effective Majorana neutrino mass (mββ). The GERDA experiment is located in hall A of the Grand Sasso national lab (LNGS) and the construction will start in 2006

  9. The Square Kilometre Array

    Science.gov (United States)

    Huynh, Minh; Lazio, Joseph

    2011-01-01

    The Square Kilometre Array (SKA) will be the premier instrument to study radiation at centimetre and metre wavelengths from the cosmos, and in particular neutral hydrogen, the most abundant element in the universe. The SKA will probe the dawn of galaxy formation as well as allow advances in many other areas of astronomy, such as fundamental physics, astro-biology and cosmology. The SKA will have a collecting area of up to one million square metres spread over at least 3000 km, providing a collecting area more than twenty times greater than the current largest radio telescope. Its field of view on the sky will be several tens of square degrees with potentially several large (100 square degrees) independent beams at the lower frequencies, providing a survey speed many thousands of times greater than current facilities. This paper summarises the key science drivers of the SKA and provides an update on the international project.

  10. Diagnosable structured logic array

    Science.gov (United States)

    Whitaker, Sterling (Inventor); Miles, Lowell (Inventor); Gambles, Jody (Inventor); Maki, Gary K. (Inventor)

    2009-01-01

    A diagnosable structured logic array and associated process is provided. A base cell structure is provided comprising a logic unit comprising a plurality of input nodes, a plurality of selection nodes, and an output node, a plurality of switches coupled to the selection nodes, where the switches comprises a plurality of input lines, a selection line and an output line, a memory cell coupled to the output node, and a test address bus and a program control bus coupled to the plurality of input lines and the selection line of the plurality of switches. A state on each of the plurality of input nodes is verifiably loaded and read from the memory cell. A trusted memory block is provided. The associated process is provided for testing and verifying a plurality of truth table inputs of the logic unit.

  11. Scintillator detector array

    International Nuclear Information System (INIS)

    This patent application relates to a scintillator detector array for use in computerized tomography and comprises a housing including a plurality of chambers, the said housing having a front wall transmissive to x-rays and side walls opaque to x-rays, such as of tungsten and tantalum, a liquid scintillation medium including a soluble fluor, the solvent for the fluor being disposed in the chambers. The solvent comprises either an intrinsically high Z solvent or a solvent which has dissolved therein a high Z compound e.g. iodo or bromonaphthalene; or toluene, xylene or trimethylbenzene with a lead or tin alkyl dissolved therein. Also disposed about the chambers are a plurality of photoelectric devices. (author)

  12. Networked Sensor Arrays

    International Nuclear Information System (INIS)

    A set of independent radiation sensors, coupled with real-time data telemetry, offers the opportunity to run correlation algorithms for the sensor array as well as to incorporate non-radiological data into the system. This may enhance the overall sensitivity of the sensors and provide an opportunity to project the location of a source within the array. In collaboration with Lawrence Livermore National Laboratory (LLNL) and Sandia National Laboratories (SNL), we have conducted field experiments to test a prototype system. Combining the outputs of a set of distributed sensors permits the correlation that the independent sensor outputs. Combined with additional information such as traffic patterns and velocities, this can reduce random/false detections and enhance detection capability. The principle components of such a system include: (1) A set of radiation sensors. These may be of varying type and complexity, including gamma and/or neutron detectors, gross count and spectral-capable sensors, and low to high energy-resolution sensors. (2) A set of non-radiation sensors. These may include sensors such as vehicle presence and imaging sensors. (3) A communications architecture for near real-time telemetry. Depending upon existing infrastructure and bandwidth requirements, this may be a radio or hard-wire based system. (4) A central command console to pole the sensors, correlate their output, and display the data in a meaningful form to the system operator. Both sensitivity and selectivity are important considerations when evaluating the performance of a detection system. Depending on the application, the optimization of sensitivity as well as the rejection of ''nuisance'' radioactive sources may or may not be critical

  13. Expander Families and Cayley Graphs A Beginner's Guide

    CERN Document Server

    Krebs, Mike

    2011-01-01

    The theory of expander graphs is a rapidly developing topic in mathematics and computer science, with applications to communication networks, error-correcting codes, cryptography, complexity theory, and much more. Expander Families and Cayley Graphs: A Beginner's Guide is a comprehensive introduction to expander graphs, designed to act as a bridge between classroom study and active research in the field of expanders. It equips those with little or no prior knowledge with the skills necessary to both comprehend current research articles and begin their own research. Central to this book are fou

  14. Infrastructure Requirements for an Expanded Fuel Ethanol Industry

    Energy Technology Data Exchange (ETDEWEB)

    Reynolds, Robert E. [Downstream Alternatives, Inc., South Bend, IN (United States)

    2002-01-15

    This report provides technical information specifically related to ethanol transportation, distribution, and marketing issues. This report required analysis of the infrastructure requirements for an expanded ethanol industry.

  15. Expandable and rigid endorectal coils for prostate MRI: impact on prostate distortion and rigid image registration.

    Science.gov (United States)

    Kim, Yongbok; Hsu, I-Chow J; Pouliot, Jean; Noworolski, Susan Moyher; Vigneron, Daniel B; Kurhanewicz, John

    2005-12-01

    Endorectal coils (ERCs) are used for acquiring high spatial resolution magnetic resonance (MR) images of the human prostate. The goal of this study is to determine the impact of an expandable versus a rigid ERC on changes in the location and deformation of the prostate gland and subsequently on registering prostate images acquired with and without an ERC. Sagittal and axial T2 weighted MR images were acquired from 25 patients receiving a combined MR imaging/MR spectroscopic imaging staging exam for prostate cancer. Within the same exam, images were acquired using an external pelvic phased array coil both alone and in combination with either an expandable ERC (MedRad, Pittsburgh, PA) or a rigid ERC (USA Instruments, Aurora, OH). Rotations, translations and deformations caused by the ERC were measured and compared. The ability to register images acquired with and without the ERC using a manual rigid-body registration was assessed using a similarity index (SI). Both ERCs caused the prostate to tilt anteriorly with an average tilt of 18.5 degrees (17.4 +/- 9.9 and 19.5 +/- 11.3 degrees, mean +/- standard deviation, for expandable and rigid ERC, respectively). However, the expandable coil caused a significantly larger distortion of the prostate as compared to the rigid coil; compressing the prostate in the anterior/posterior direction by 4.1 +/- 3.0 mm vs 1.2 +/- 2.2 mm (14.5% vs 4.8%) (p p = 0.004). Additionally, the ability to manually align prostate images acquired with and without ERC was significantly (p manual rigid-body alignment of prostate MR images acquired with and without the ERC can be improved through the use of a rigid ERC. PMID:16475755

  16. Expanding policy options for educating teenagers.

    Science.gov (United States)

    Stern, David

    2009-01-01

    David Stern argues that some basic features of the American high school must be modified if it is to serve all students successfully. He notes, for example, that only three-quarters of U.S. high school students graduate four years after beginning ninth grade and that the National Assessment of Educational Progress found no improvement in reading or mathematics for seventeen-year-olds between 1971 and 2004. The nation's system for educating teenagers, says Stern, seems to be stuck, despite the constant efforts of teachers and repeated waves of reform. Citing two widely accepted public purposes of educating teenagers-preparation for civic participation and for economic self-sufficiency-Stern proposes four new strategies to achieve those goals. He draws on empirical evidence suggesting that these are promising directions for research and policy, but acknowledges that existing studies provide only limited guidance. First, he says, schools should continue the current trend toward integrating educational options to provide young people with skills and experiences that pave the way to both college and careers. Second, states and districts should tie education funding not simply to the number of students attending school, but also to what young people learn, whether they graduate, and whether they find jobs or enroll in postsecondary education. Such a move, he argues, would encourage teaching and learning formats that use students' time more effectively. Third, more adults in addition to classroom teachers should be involved in educating teenagers. Other adults acting as academic advisers, learning coaches, student advocates, internship supervisors, mentors, and college counselors could help guide the education of teenagers inside and outside of school and provide some relief for the chronic shortage of teachers. Fourth, schools should expand the options for educating teenagers outside of geographically fixed schools. Combining improved Internet-based curriculum with

  17. Acoustic Eaton lens array and its fluid application

    CERN Document Server

    Kim, Sang-Hoon; Das, Mukunda P

    2016-01-01

    A principle of an acoustic Eaton Lens array and its application as a removable tsunami wall is proposed theoretically. The lenses are made of expandable rubber balloons and create a stop-band by the rotating the incoming tsunami wave and reduce the pressure by canceling each other. The diameter of each lens is larger than the wavelength of the tsunami near the coast, that is, order of a kilometer. The impedance matching on the border of the lenses results in little reflection. Before a tsunami, the balloons are buried underground in shallow water near the coast in folded or rounded form. Upon sounding of the tsunami alarm, water and air are pumped into the balloons, which expand and erect the wall above the sea level within a few hours. After the tsunami, the water and air are released from the balloons, which are then buried underground for reuse. Electricity is used to power the entire process.

  18. In Vitro Comparison of Self-Expanding Versus Balloon-Expandable Stents in a Human Ex Vivo Model

    International Nuclear Information System (INIS)

    The objective was to compare the radial strength and expansile precision of self-expanding stents and balloon-expandable stents in a human cadaver bifurcation model. Seven different self-expanding (LUMINEXX, JOSTENT SelfX, JOSTENT SelfX hrf, Sinus-Repo, Sinus SuperFlex, Easy Wallstent, SMART) and four different balloon-expandable stent models (Palmaz, Sinus Stent, SAXX Medium, JOSTENT peripheral), each type 10 stents (total n = 110 stents) were implanted into the common iliac arteries of human cadaver corpses. The maximum stent diameter was 10 mm for all models. After stent implantation, the specimens were filled with silicone caoutchouc. After 24 h, the vascular walls including the stents were removed from the hardened casts. Diameters were taken and the weight of the cast cylinders was measured in air and in purified water to calculate the volume of the bodies (according to Archimedes Law) as a relative but precise degree for the radial strength of the implanted stents. The cylindrical casts of the self-expanding stents showed lower mean diameters (8.2 ± 1.0 mm) and mean volumes (0.60 ± 0.14 ml/cm) than in the balloon-expandable stent group (10.1 ± 0.3 mm and 0.71 ± 0.04 ml/cm, respectively; p < 0.01). The nominal maximum diameter of 10 mm was not achieved in any of the self-expanding stents, but this was achieved in more than 70% (29/40) of the balloon-expandable stent specimens (p < 0.05). The variation between achieved volumes was significantly larger in self-expanding (range: 0.23-0.78 ml/cm) than in balloon-expandable stents (range: 0.66-0.81 ml/cm; p < 0.05). Self-expanding stents presented considerably lower radial expansion force and lower degree of precision than balloon-expandable stents

  19. Array tomography: semiautomated image alignment.

    Science.gov (United States)

    Micheva, Kristina D; O'Rourke, Nancy; Busse, Brad; Smith, Stephen J

    2010-11-01

    Array tomography is a volumetric microscopy method based on physical serial sectioning. Ultrathin sections of a plastic-embedded tissue are cut using an ultramicrotome, bonded in an ordered array to a glass coverslip, stained as desired, and imaged. The resulting two-dimensional image tiles can then be reconstructed computationally into three-dimensional volume images for visualization and quantitative analysis. The minimal thickness of individual sections permits high-quality rapid staining and imaging, whereas the array format allows reliable and convenient section handling, staining, and automated imaging. Also, the physical stability of the arrays permits images to be acquired and registered from repeated cycles of staining, imaging, and stain elution, as well as from imaging using multiple modalities (e.g., fluorescence and electron microscopy). Array tomography makes it possible to visualize and quantify previously inaccessible features of tissue structure and molecular architecture. However, careful preparation of the tissue is essential for successful array tomography; these steps can be time-consuming and require some practice to perfect. Successful array tomography requires that the captured images be properly stacked and aligned, and the software to achieve these ends is freely available. This protocol describes the construction of volumetric image stacks from images of fluorescently labeled arrays for three-dimensional image visualization, analysis, and archiving. PMID:21041400

  20. Cyclotron-Resonance-Maser Arrays

    International Nuclear Information System (INIS)

    The cyclotron-resonance-maser (CRM) array [1] is a radiation source which consists of CRM elements coupled together under a common magnetic field. Each CRM-element employs a low-energy electron-beam which performs a cyclotron interaction with the local electromagnetic wave. These waves can be coupled together among the CRM elements, hence the interaction is coherently synchronized in the entire array. The implementation of the CRM-array approach may alleviate several technological difficulties which impede the development of single-beam gyro-devices. Furthermore, it proposes new features, such as the phased-array antenna incorporated in the CRM-array itself. The CRM-array studies may lead to the development of compact, high-power radiation sources operating at low-voltages. This paper introduces new conceptual schemes of CRM-arrays, and presents the progress in related theoretical and experimental studies in our laboratory. These include a multi-mode analysis of a CRM-array, and a first operation of this device with five carbon-fiber cathodes

  1. Passive microfluidic array card and reader

    Energy Technology Data Exchange (ETDEWEB)

    Dugan, Lawrence Christopher (Modesto, CA); Coleman, Matthew A. (Oakland, CA)

    2011-08-09

    A microfluidic array card and reader system for analyzing a sample. The microfluidic array card includes a sample loading section for loading the sample onto the microfluidic array card, a multiplicity of array windows, and a transport section or sections for transporting the sample from the sample loading section to the array windows. The microfluidic array card reader includes a housing, a receiving section for receiving the microfluidic array card, a viewing section, and a light source that directs light to the array window of the microfluidic array card and to the viewing section.

  2. Line-scanning diode-array digital chest imaging

    International Nuclear Information System (INIS)

    A line scanning diode array digital chest diagnostic x-ray machine has been developed which captures very high detail through the use of self-scanning linear diode arrays. The authors' latest model represents a significant improvement over our previous ones in the following aspects: (1) The U-arm gantry containing the x-ray tube and detector assembly is moved during the scanning and the patient therefore does not move. (2) The digital images can be taken with the patient standing. (3) The field of view has been increased to include the entire chest. (4) The matrix size has been greatly expanded. (5) A newly developed rare earth phosphor screen with much higher resolution and good absorption is used. The images are digitally processed, resulting in a balanced image in which structures in all regions of the chest are simultaneously displayed with optimum contrast

  3. Using Phased Array for Transverse Oscillation Vector Velocity Imaging

    DEFF Research Database (Denmark)

    Pihl, Michael Johannes; Haugaard, Per; Jensen, Jørgen Arendt

    be expanded to phased arrays enabling vector velocity imaging of the heart. Therefore, the performance of the TO estimator has to be evaluated for depths up to 10-15 cm. Methods The TO method is based on creating a double oscillating field. Flow phantoms were simulated with a transverse (90º) parabolic flow...... profile (peak = 1 m/s) and a vessel radius of 5 mm, and ‘scanned’ orthogonal to the flow with a 3.5 MHz phased array transducer. The performance of the lateral velocity estimates were evaluated by calculating the relative mean bias, Br, and relative mean standard deviation, σr, inside the vessel of N=20...

  4. Chunking of Large Multidimensional Arrays

    Energy Technology Data Exchange (ETDEWEB)

    Rotem, Doron; Otoo, Ekow J.; Seshadri, Sridhar

    2007-02-28

    Data intensive scientific computations as well on-lineanalytical processing applications as are done on very large datasetsthat are modeled as k-dimensional arrays. The storage organization ofsuch arrays on disks is done by partitioning the large global array intofixed size hyper-rectangular sub-arrays called chunks or tiles that formthe units of data transfer between disk and memory. Typical queriesinvolve the retrieval of sub-arrays in a manner that accesses all chunksthat overlap the query results. An important metric of the storageefficiency is the expected number of chunks retrieved over all suchqueries. The question that immediately arises is "what shapes of arraychunks give the minimum expected number of chunks over a query workload?"In this paper we develop two probabilistic mathematical models of theproblem and provide exact solutions using steepest descent and geometricprogramming methods. Experimental results, using synthetic workloads onreal life data sets, show that our chunking is much more efficient thanthe existing approximate solutions.

  5. SAQC: SNP Array Quality Control

    Directory of Open Access Journals (Sweden)

    Li Ling-Hui

    2011-04-01

    Full Text Available Abstract Background Genome-wide single-nucleotide polymorphism (SNP arrays containing hundreds of thousands of SNPs from the human genome have proven useful for studying important human genome questions. Data quality of SNP arrays plays a key role in the accuracy and precision of downstream data analyses. However, good indices for assessing data quality of SNP arrays have not yet been developed. Results We developed new quality indices to measure the quality of SNP arrays and/or DNA samples and investigated their statistical properties. The indices quantify a departure of estimated individual-level allele frequencies (AFs from expected frequencies via standardized distances. The proposed quality indices followed lognormal distributions in several large genomic studies that we empirically evaluated. AF reference data and quality index reference data for different SNP array platforms were established based on samples from various reference populations. Furthermore, a confidence interval method based on the underlying empirical distributions of quality indices was developed to identify poor-quality SNP arrays and/or DNA samples. Analyses of authentic biological data and simulated data show that this new method is sensitive and specific for the detection of poor-quality SNP arrays and/or DNA samples. Conclusions This study introduces new quality indices, establishes references for AFs and quality indices, and develops a detection method for poor-quality SNP arrays and/or DNA samples. We have developed a new computer program that utilizes these methods called SNP Array Quality Control (SAQC. SAQC software is written in R and R-GUI and was developed as a user-friendly tool for the visualization and evaluation of data quality of genome-wide SNP arrays. The program is available online (http://www.stat.sinica.edu.tw/hsinchou/genetics/quality/SAQC.htm.

  6. The Cherenkov Telescope Array For Very High-Energy Astrophysics

    Science.gov (United States)

    Kaaret, Philip

    2015-08-01

    The field of very high energy (VHE) astrophysics had been revolutionized by the results from ground-based gamma-ray telescopes, including the current imaging atmospheric Cherenkov telescope (IACT) arrays: HESS, MAGIC and VERITAS. A worldwide consortium of scientists from 29 countries has formed to propose the Cherenkov Telescope Array (CTA) that will capitalize on the power of this technique to greatly expand the scientific reach of ground-based gamma-ray telescopes. CTA science will include key topics such as the origin of cosmic rays and cosmic particle acceleration, understanding extreme environments in regions close to neutron stars and black holes, and exploring physics frontiers through, e.g., the search for WIMP dark matter, axion-like particles and Lorentz invariance violation. CTA is envisioned to consist of two large arrays of Cherenkov telescopes, one in the southern hemisphere and one in the north. Each array will contain telescopes of different sizes to provide a balance between cost and array performance over an energy range from below 100 GeV to above 100 TeV. Compared to the existing IACT arrays, CTA will have substantially better angular resolution and energy resolution, will cover a much wider energy range, and will have up to an order of magnitude better sensitivity. CTA will also be operated as an open observatory and high-level CTA data will be placed into the public domain; these aspects will enable broad participation in CTA science from the worldwide scientific community to fully capitalize on CTA's potential. This talk will: 1) review the scientific motivation and capabilities of CTA, 2) provide an overview of the technical design and the status of prototype development, and 3) summarize the current status of the project in terms of its proposed organization and timeline. The plans for access to CTA data and opportunities to propose for CTA observing time will be highlighed.Presented on behalf of the CTA Consortium.

  7. Asymptotic estimates and compactness of expanding gradient Ricci solitons

    OpenAIRE

    Deruelle, Alix

    2014-01-01

    We first investigate the asymptotics of conical expanding gradient Ricci solitons by proving sharp decay rates to the asymptotic cone both in the generic and the asymptotically Ricci flat case. We then establish a compactness theorem concerning nonnegatively curved expanding gradient Ricci solitons.

  8. Quark energy loss in an expanding quark-gluon plasma

    OpenAIRE

    Zakharov, B. G.

    1998-01-01

    We study the quark energy loss in an expanding quark-gluon plasma. The expanding plasma produced in high energy AA-collision is described by Bjorken's model. The dependence of the energy loss on the infrared cutoff for the radiated gluons, on the quark mass, and on the initial conditions of QCD plasma is investigated.

  9. An Isothermal Steam Expander for an Industrial Steam Supplying System

    Directory of Open Access Journals (Sweden)

    Chen-Kuang Lin

    2015-01-01

    Full Text Available Steam is an essential medium used in the industrial process. To ensure steam quality, small and middle scale boilers are often adopted. However, because a higher steam pressure (compared to the necessary steam pressure is generated, the boiler’s steam pressure will be reduced via a pressure regulator before the steam is directed through the process. Unfortunately, pressure is somewhat wasted during the reducing process. Therefore, in order to promote energy efficiency, a pressure regulator is replaced by a steam expander. With this steam expander, the pressure will be transformed into mechanical energy and extracted during the expansion process. A new type of isothermal steam expander for an industrial steam supplying system will be presented in the paper. The isothermal steam expander will improve the energy efficiency of a traditional steam expander by replacing the isentropic process with an isothermal expansion process. With this, steam condensation will decrease, energy will increase, and steam quality will be improved. Moreover, the mathematical model of the isothermal steam expander will be established by using the Schmidt theory, the same principle used to analyze Stirling engines. Consequently, by verifying the correctness of the theoretical model for the isothermal steam expander using experimental data, a prototype of 100 c.c. isothermal steam expander is constructed.

  10. Principles of the fifth order tuning of beam expanders

    International Nuclear Information System (INIS)

    An analytical treatment of the third and fifth order optics of beam expanders is described, which allows precise tuning of the optical elements of the beam line, and efficient optimization of the beam uniformizing at the extended target. An application to a two-dimensional expander is given as an illustration. (authors)

  11. NECTAr: New electronics for the Cherenkov Telescope Array

    International Nuclear Information System (INIS)

    The European astroparticle physics community aims to design and build the next generation array of Imaging Atmospheric Cherenkov Telescopes (IACTs), that will benefit from the experience of the existing H.E.S.S. and MAGIC detectors, and further expand the very-high energy astronomy domain. In order to gain an order of magnitude in sensitivity in the 10 GeV to >100TeV range, the Cherenkov Telescope Array (CTA) will employ 50-100 mirrors of various sizes equipped with 1000-4000 channels per camera, to be compared with the 6000 channels of the final H.E.S.S. array. A 3-year program, started in 2009, aims to build and test a demonstrator module of a generic CTA camera. We present here the NECTAr design of front-end electronics for the CTA, adapted to the trigger and data acquisition of a large IACTs array, with simple production and maintenance. Cost and camera performances are optimized by maximizing integration of the front-end electronics (amplifiers, fast analog samplers, ADCs) in an ASIC, achieving several GS/s and a few μs readout dead-time. We present preliminary results and extrapolated performances from Monte Carlo simulations.

  12. Crystallization degree change of expanded graphite by milling and annealing

    Energy Technology Data Exchange (ETDEWEB)

    Tang Qunwei [Key Laboratory for Functional Materials of Fujian Higher Education, Institute of Material Physical Chemistry, Huaqiao University, Quanzhou 362021 (China); Wu Jihuai [Key Laboratory for Functional Materials of Fujian Higher Education, Institute of Material Physical Chemistry, Huaqiao University, Quanzhou 362021 (China)], E-mail: jhwu@hqu.edu.cn; Sun Hui; Fang Shijun [Key Laboratory for Functional Materials of Fujian Higher Education, Institute of Material Physical Chemistry, Huaqiao University, Quanzhou 362021 (China)

    2009-05-05

    Expanded graphite was ball milled with a planetary mill in air atmosphere, and subsequently thermal annealed. The samples were characterized by using X-ray diffraction spectroscopy (XRD), scanning electron microscopy (SEM) and thermal gravimetric analysis (TGA). It was found that in the milling initial stage (less than 12 h), the crystallization degree of the expanded graphite declined gradually, but after milling more than 16 h, a recrystallization of the expanded graphite toke place, and ordered nanoscale expanded graphite was formed gradually. In the annealing initial stage, the non-crystallization of the graphite occurred, but, beyond an annealing time, recrystallizations of the graphite arise. Higher annealing temperature supported the recrystallization. The milled and annealed expanded graphite still preserved the crystalline structure as raw material and hold high thermal stability.

  13. The Cherenkov Telescope Array

    CERN Document Server

    Bigongiari, Ciro

    2016-01-01

    The Cherenkov Telescope Array (CTA) is planned to be the next generation ground based observatory for very high energy (VHE) gamma-ray astronomy. Gamma-rays provide a powerful insight into the non-thermal universe and hopefully a unique probe for new physics. Imaging Cherenkov telescopes have already discovered more than 170 VHE gamma-ray emitters providing plentiful of valuable data and clearly demonstrating the power of this technique. In spite of the impressive results there are indications that the known sources represent only the tip of the iceberg. A major step in sensitivity is needed to increase the number of detected sources, observe short time-scale variability and improve morphological studies of extended sources. An extended energy coverage is advisable to observe far-away extragalactic objects and improve spectral analysis. CTA aims to increase the sensitivity by an order of magnitude compared to current facilities, to extend the accessible gamma-ray energies from a few tens of GeV to a hundred o...

  14. VLSI array processor

    Science.gov (United States)

    Greenwood, E.

    1982-07-01

    The Arithmetic Processor Unit (APU) data base design check was completed. Minor design rule violations and design improvements were accomplished. The APU mask set has been fabricated and checked. Initial checking of all mask layers revealed a design rule problem in one layer. That layer was corrected, refabricated and checked out. The mask set has been delivered to the chip fabrication area. The fabrication process has been initiated. All work on the Array Processor Demonstration System (APDS) has been suspended at CHI until the additionally requested funding was received. That funding has been authorized and CHI will begin work on the APDS in July. The following activities are planned in the following quarter: 1) Complete fabrication of the first lot of VLSI APU devices. 2) Complete integration and check-out of the APDS simulator. 3) Complete integration and check-out of the APU breadboard. 4) Verify the VLSI APU wafer tests with the APU breadboard. 5) Complete check-out of the APDS using the APU breadboard.

  15. Freeform array projection

    Science.gov (United States)

    Michaelis, D.; Schreiber, P.; Li, C.; Bräuer, A.; Gross, H.

    2015-09-01

    The concept of multichannel array projection is generalized in order to realize an ultraslim, highly efficient optical system for structured illumination with high lumen output, where additionally the Köhler illumination principle is utilized and source light homogenization occurs. The optical system consists of a multitude of neighboring optical channels. In each channel two optical freeforms generate a real or a virtual spatial light pattern and furthermore, the ray directions are modified to enable Köhler illumination of a subsequent projection lens. The internal light pattern may be additionally influenced by absorbing apertures or slides. The projection lens transfers the resulting light pattern to a target, where the total target distribution is produced by superposition of all individual channel output pattern. The optical system without absorbing apertures can be regarded as a generalization of a fly's eye condenser for structured illumination. In this case light pattern is exclusively generated by freeform light redistribution. The commonly occurring blurring effect for freeform beamshaping is reduced due to the creation of a virtual object light structure by means of the two freeform surfaces and its imaging towards the target. But, the remaining blurring inhibits very high spatial frequencies at the target. In order to create target features with very high spatial resolution the absorbing apertures can be utilized. In this case the freeform beamshaping can be used for an enhanced light transmission through the absorbing apertures. The freeform surfaces are designed by a generalized approach of Cartesian oval representation.

  16. Distant Supernovae Indicate Ever-Expanding Universe

    Science.gov (United States)

    1998-12-01

    ESO Astronomers Contribute towards Resolution of Cosmic Puzzle Since the discovery of the expansion of the Universe by American astronomer Edwin Hubble in the 1920's, by measurement of galaxy velocities, astronomers have tried to learn how this expansion changes with time. Until now, most scientists have been considering two possibilities: the expansion rate is slowing down and will ultimately either come to a halt - whereafter the Universe would start to contract, or it will continue to expand forever. However, new studies by two independent research teams, based on observations of exploding stars ( supernovae ) by ESO astronomers [1] with astronomical telescopes at the La Silla Observatory as well as those of their colleagues at other institutions, appear to show that the expansion of the Universe is accelerating . The results take the discovery of the cosmological expansion one step further and challenge recent models of the Universe. If the new measurements are indeed correct, they show that the elusive "cosmological constant" , as proposed by Albert Einstein , contributes significantly to the evolution of the Universe. The existence of a non-zero cosmological constant implies that a repulsive force, counter-acting gravity, currently dominates the universal expansion , and consequently leads to an ever-expanding Universe. This new research is being named as the "Breakthrough of the Year" by the renowned US science journal Science in the December 18, 1998, issue. A Press Release is published by the journal on this occasion. "Fundamental Parameters" of the Universe Three fundamental parameters govern all cosmological models based on the theory of General Relativity. They are 1. the current expansion rate as described by Hubble's constant , i.e. the proportionality factor between expansion velocity and distance 2. the average matter density in the Universe, and 3. the amount of "other energy" present in space. From the measured values of these fundamental

  17. CLAES focal plane array. [Cryogenic Limb Array Etalon Spectrometer

    Science.gov (United States)

    Roche, A. E.; Sterritt, L. W.; Kumer, J. B.; Callary, P. C.; Nielsen, R. L.

    1989-01-01

    The Cryogenic Limb Array Etalon Spectrometer for the NASA Upper Atmospheric Research Satellite uses solid-state focal plane arrays to detect emission from the earth's atmosphere over the IR wavelength range 3.5 to 13 microns. This paper discusses the design of the focal plane detector assembly and compares calculated performance with measurements. Measurements were made of focal plane noise and responsivity as functions of frequency (2 to 500 Hz) and temperature (12 to 19 K), pixel-to-pixel and across-array crosstalk, and linearity over a dynamic range of 100,000. The measurements demonstrate that the arrays satisfy the science requirements, and that, in general, there is reasonable agreement between the measurements and the analytical model.

  18. Large scale biomimetic membrane arrays

    DEFF Research Database (Denmark)

    Hansen, Jesper Søndergaard; Perry, Mark; Vogel, Jörg;

    2009-01-01

    peptides and proteins. Next, we tested the scalability of the biomimetic membrane design by establishing lipid bilayers in rectangular 24 x 24 and hexagonal 24 x 27 aperture arrays, respectively. The results presented show that the design is suitable for further developments of sensitive biosensor assays......To establish planar biomimetic membranes across large scale partition aperture arrays, we created a disposable single-use horizontal chamber design that supports combined optical-electrical measurements. Functional lipid bilayers could easily and efficiently be established across CO2 laser micro......, and furthermore demonstrate that the design can conveniently be scaled up to support planar lipid bilayers in large square-centimeter partition arrays....

  19. Fundamentals of ultrasonic phased arrays

    CERN Document Server

    Schmerr, Lester W

    2014-01-01

    This book describes in detail the physical and mathematical foundations of ultrasonic phased array measurements.?The book uses linear systems theory to develop a comprehensive model of the signals and images that can be formed with phased arrays. Engineers working in the field of ultrasonic nondestructive evaluation (NDE) will find in this approach a wealth of information on how to design, optimize and interpret ultrasonic inspections with phased arrays. The fundamentals and models described in the book will also be of significant interest to other fields, including the medical ultrasound and

  20. Antenna arrays a computational approach

    CERN Document Server

    Haupt, Randy L

    2010-01-01

    This book covers a wide range of antenna array topics that are becoming increasingly important in wireless applications, particularly in design and computer modeling. Signal processing and numerical modeling algorithms are explored, and MATLAB computer codes are provided for many of the design examples. Pictures of antenna arrays and components provided by industry and government sources are presented with explanations of how they work. Antenna Arrays is a valuable reference for practicing engineers and scientists in wireless communications, radar, and remote sensing, and an excellent textbook for advanced antenna courses.

  1. DFB Quantum Cascade Laser Arrays

    OpenAIRE

    Lee, Benjamin G.; Belkin, Mikhail A.; Pflügl, Christian; Diehl, Laurent; Zhang, Haifei; Audet, Ross M.; MacArthur, Jim B.; Bour, David P.; Corzine, Scott W.; Höfler, Gloria E.; Capasso, Federico

    2009-01-01

    DFB quantum cascade laser (DFB-QCL) arrays operating between 8.7 and 9.4 mum are investigated for their performance characteristics-single-mode selection of the DFB grating, and variability in threshold, slope efficiency, and output power of different lasers in the array. Single-mode selection refers to the ability to choose a desired mode/frequency of laser emission with a DFB grating. We apply a theoretical framework developed for general DFB gratings to analyze DFB-QCL arrays. We calculate...

  2. Silicon Heat Pipe Array

    Science.gov (United States)

    Yee, Karl Y.; Ganapathi, Gani B.; Sunada, Eric T.; Bae, Youngsam; Miller, Jennifer R.; Beinsford, Daniel F.

    2013-01-01

    Improved methods of heat dissipation are required for modern, high-power density electronic systems. As increased functionality is progressively compacted into decreasing volumes, this need will be exacerbated. High-performance chip power is predicted to increase monotonically and rapidly with time. Systems utilizing these chips are currently reliant upon decades of old cooling technology. Heat pipes offer a solution to this problem. Heat pipes are passive, self-contained, two-phase heat dissipation devices. Heat conducted into the device through a wick structure converts the working fluid into a vapor, which then releases the heat via condensation after being transported away from the heat source. Heat pipes have high thermal conductivities, are inexpensive, and have been utilized in previous space missions. However, the cylindrical geometry of commercial heat pipes is a poor fit to the planar geometries of microelectronic assemblies, the copper that commercial heat pipes are typically constructed of is a poor CTE (coefficient of thermal expansion) match to the semiconductor die utilized in these assemblies, and the functionality and reliability of heat pipes in general is strongly dependent on the orientation of the assembly with respect to the gravity vector. What is needed is a planar, semiconductor-based heat pipe array that can be used for cooling of generic MCM (multichip module) assemblies that can also function in all orientations. Such a structure would not only have applications in the cooling of space electronics, but would have commercial applications as well (e.g. cooling of microprocessors and high-power laser diodes). This technology is an improvement over existing heat pipe designs due to the finer porosity of the wick, which enhances capillary pumping pressure, resulting in greater effective thermal conductivity and performance in any orientation with respect to the gravity vector. In addition, it is constructed of silicon, and thus is better

  3. Tissue regeneration during tissue expansion and choosing an expander

    Directory of Open Access Journals (Sweden)

    K Agrawal

    2012-01-01

    Full Text Available This paper reviews the various aspects of tissue regeneration during the process of tissue expansion. "Creep" and mechanical and biological "stretch" are responsible for expansion. During expansion, the epidermis thickens, the dermis thins out, vascularity improves, significant angiogenesis occurs, hair telogen phase becomes shorter and the peripheral nerves, vessels and muscle fibres lengthen. Expansion is associated with molecular changes in the tissue. Almost all these biological changes are reversible after the removal of the expander.This study is also aimed at reviewing the difficulty in deciding the volume and dimension of the expander for a defect. Basic mathematical formulae and the computer programmes for calculating the dimension of tissue expanders, although available in the literature, are not popular. A user-friendly computer programme based on the easily available Microsoft Excel spread sheet has been introduced. When we feed the area of defect and base dimension of the donor area or tissue expander, this programme calculates the volume and height of the expander. The shape of the expander is decided clinically based on the availability of the donor area and the designing of the future tissue movement. Today, tissue expansion is better understood biologically and mechanically. Clinical judgement remains indispensable in choosing the size and shape of the tissue expander.

  4. Fundamentals of spherical array processing

    CERN Document Server

    Rafaely, Boaz

    2015-01-01

    This book provides a comprehensive introduction to the theory and practice of spherical microphone arrays. It is written for graduate students, researchers and engineers who work with spherical microphone arrays in a wide range of applications.   The first two chapters provide the reader with the necessary mathematical and physical background, including an introduction to the spherical Fourier transform and the formulation of plane-wave sound fields in the spherical harmonic domain. The third chapter covers the theory of spatial sampling, employed when selecting the positions of microphones to sample sound pressure functions in space. Subsequent chapters present various spherical array configurations, including the popular rigid-sphere-based configuration. Beamforming (spatial filtering) in the spherical harmonics domain, including axis-symmetric beamforming, and the performance measures of directivity index and white noise gain are introduced, and a range of optimal beamformers for spherical arrays, includi...

  5. The Murchison Widefield Array Correlator

    CERN Document Server

    Ord, S M; Emrich, D; Pallot, D; Wayth, R B; Clark, M A; Tremblay, S E; Arcus, W; Barnes, D; Bell, M; Bernardi, G; Bhat, N D R; Bowman, J D; Briggs, F; Bunton, J D; Cappallo, R J; Corey, B E; Deshpande, A A; deSouza, L; Ewell-Wice, A; Feng, L; Goeke, R; Greenhill, L J; Hazelton, B J; Herne, D; Hewitt, J N; Hindson, L; Hurley-Walker, H; Jacobs, D; Johnston-Hollitt, M; Kaplan, D L; Kasper, J C; Kincaid, B B; Koenig, R; Kratzenberg, E; Kudryavtseva, N; Lenc, E; Lonsdale, C J; Lynch, M J; McKinley, B; McWhirter, S R; Mitchell, D A; Morales, M F; Morgan, E; Oberoi, D; Offringa, A; Pathikulangara, J; Pindor, B; Prabu, T; Procopio, P; Remillard, R A; Riding, J; Rogers, A E E; Roshi, A; Salah, J E; Sault, R J; Shankar, N Udaya; Srivani, K S; Stevens, J; Subrahmanyan, R; Tingay, S J; Waterson, M; Webster, R L; Whitney, A R; Williams, A; Williams, C L; Wyithe, J S B

    2015-01-01

    The Murchison Widefield Array (MWA) is a Square Kilometre Array (SKA) Precursor. The telescope is located at the Murchison Radio--astronomy Observatory (MRO) in Western Australia (WA). The MWA consists of 4096 dipoles arranged into 128 dual polarisation aperture arrays forming a connected element interferometer that cross-correlates signals from all 256 inputs. A hybrid approach to the correlation task is employed, with some processing stages being performed by bespoke hardware, based on Field Programmable Gate Arrays (FPGAs), and others by Graphics Processing Units (GPUs) housed in general purpose rack mounted servers. The correlation capability required is approximately 8 TFLOPS (Tera FLoating point Operations Per Second). The MWA has commenced operations and the correlator is generating 8.3 TB/day of correlation products, that are subsequently transferred 700 km from the MRO to Perth (WA) in real-time for storage and offline processing. In this paper we outline the correlator design, signal path, and proce...

  6. Integrated Spatial Filter Array Project

    Data.gov (United States)

    National Aeronautics and Space Administration — To address the NASA Earth Science Division need for spatial filter arrays for amplitude and wavefront control, Luminit proposes to develop a novel Integrated...

  7. Light propagation in nanorod arrays

    CERN Document Server

    Rahachou, A I

    2006-01-01

    We study propagation of TM- and TE-polarized light in two-dimensional arrays of silver nanorods of various diameters in a gelatin background. We calculate the transmittance, reflectance and absorption of arranged and disordered nanorod arrays and compare the exact numerical results with the predictions of the Maxwell-Garnett effective-medium theory. We show that interactions between nanorods, multipole contributions and formations of photonic gaps affect strongly the transmittance spectra that cannot be accounted for in terms of the conventional effective-medium theory. We also demonstrate and explain the degradation of the transmittance in arrays with randomly located rods as well as weak influence of their fluctuating diameter. For TM modes we outline the importance of skin-effect, which causes the full reflection of the incoming light. We then illustrate the possibility of using periodic arrays of nanorods as high-quality polarizers.

  8. Thermopile Area Array Readout Project

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA/JPL thermopile detector linear arrays, wire bonded to Black Forest Engineering (BFE) CMOS readout integrated circuits (ROICs), have been utilized in NASA...

  9. Next Generation Microshutter Arrays Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to develop the next generation MicroShutter Array (MSA) as a multi-object field selector for missions anticipated in the next two decades. For many...

  10. Uniformly expanding vacuum: a possible interpretation of the dark energy

    CERN Document Server

    Huang, Peng

    2016-01-01

    Following the spirit of the equivalence principle, we take a step further to recognize the free fall of the observer as a method to eliminate causes that would lead the perceived vacuum to change its original state. Thus, it is expected that the vacuum should be in a rigid Minkowski state or be uniformly expanding. By carefully investigating the impact on measurement caused by the expansion, we clarify the exact meaning of the uniformly expanding vacuum and find that the cosmological-constant-like dark energy is in fact a manifestation and the observational confirmation of uniformly expanding vacuum.

  11. Rupture of an expander prosthesis mimics axillary cancer recurrence.

    LENUS (Irish Health Repository)

    Ismael, T

    2005-10-01

    Regional silicone gel migration from a ruptured breast implant has been reported at different locations including the upper extremity, chest wall muscles, axilla and back. We report a patient who presented with an axillary mass that mimicked a regional recurrence 5 years after breast cancer reconstruction with a latissimus dorsi musculocutaneous flap and silicon gel expander-prosthesis. Surgical exploration revealed that the mass contained silicone gel around the port of the breast expander that had ruptured. The mass was confluent with an intracapsular silicone leak through a tract along the tube of the expander port.

  12. On The Relativity of Redshifts: Does Space Really "Expand"?

    CERN Document Server

    Lewis, Geraint F

    2016-01-01

    In classes on cosmology, students are often told that photons stretch as space expands, but just how physical is this picture? Does space really expand? In this article, we explore the notion of the redshift of light with Einstein's general theory of relativity, showing that the core underpinning principles reveal that redshifts are both simpler and more complex than you might naively think. This has significant implications for the observed redshifting of photons as they travel across the universe, often refereed to as the cosmological redshift, and for the idea of expanding space.

  13. Development of an Interrupted Pulse Expanding Ring Test

    OpenAIRE

    Imbert, J; Worswick, M.

    2016-01-01

    An interrupted pulse electromagnetic (EM) expanding ring test is being developed at the University of Waterloo to study the high rate behaviour of sheet metals. In a classic EM expanding ring test, a ring is expanded radially using the forces induced on the ring by a high frequency high intensity current flowing in a nearby coil. If the driving force and the acceleration of the ring are known, then the stress-strain history of the ring can be determined. Coil currents are typic...

  14. The Applicability of Incoherent Array Processing to IMS Seismic Arrays

    Science.gov (United States)

    Gibbons, Steven J.

    2014-03-01

    The seismic arrays of the International Monitoring System (IMS) for the Comprehensive Nuclear-Test-Ban Treaty (CTBT) are highly diverse in size and configuration, with apertures ranging from under 1 km to over 60 km. Large and medium aperture arrays with large inter-site spacings complicate the detection and estimation of high-frequency phases lacking coherence between sensors. Pipeline detection algorithms often miss such phases, since they only consider frequencies low enough to allow coherent array processing, and phases that are detected are often attributed qualitatively incorrect backazimuth and slowness estimates. This can result in missed events, due to either a lack of contributing phases or by corruption of event hypotheses by spurious detections. It has been demonstrated previously that continuous spectral estimation can both detect and estimate phases on the largest aperture arrays, with arrivals identified as local maxima on beams of transformed spectrograms. The estimation procedure in effect measures group velocity rather than phase velocity, as is the case for classical f-k analysis, and the ability to estimate slowness vectors requires sufficiently large inter-sensor distances to resolve time-delays between pulses with a period of the order 4-5 s. Spectrogram beampacking works well on five IMS arrays with apertures over 20 km (NOA, AKASG, YKA, WRA, and KURK) without additional post-processing. Seven arrays with 10-20 km aperture (MJAR, ESDC, ILAR, KSRS, CMAR, ASAR, and EKA) can provide robust parameter estimates subject to a smoothing of the resulting slowness grids, most effectively achieved by convolving the measured slowness grids with the array response function for a 4 or 5 s period signal. Even for medium aperture arrays which can provide high-quality coherent slowness estimates, a complementary spectrogram beampacking procedure could act as a quality control by providing non-aliased estimates when the coherent slowness grids display

  15. Sensor arrays for detecting microorganisms

    Science.gov (United States)

    Lewis, Nathan S. (Inventor); Freund, Michael S. (Inventor)

    2000-01-01

    A sensor array for detecting a microorganism comprising first and second sensors electrically connected to an electrical measuring apparatus, wherein the sensors comprise a region of nonconducting organic material and a region of conducting material compositionally that is different than the nonconducting organic material and an electrical path through the regions of nonconducting organic material and the conducting material. A system for identifying microorganisms using the sensor array, a computer and a pattern recognition algorithm, such as a neural net are also disclosed.

  16. A calorimeter with array detectors

    International Nuclear Information System (INIS)

    A 5 x 25 = 125 detector array has been designed for a calorimeter. Each element is consisted of a graphite block and a chromel-alumel. A new '0'-point set up was designed by using the critical temperature of the liquid nitrogen as the '0'-point of the temperature. A FY-1 data acquisition system was used for the detector array. The energy distribution of the electron beam has been measured on large-area diode with the system

  17. A fixed-memory moving, expanding window for obtaining scatter corrections in X-ray CT and other stochastic averages

    Science.gov (United States)

    Levine, Zachary H.; Pintar, Adam L.

    2015-11-01

    A simple algorithm for averaging a stochastic sequence of 1D arrays in a moving, expanding window is provided. The samples are grouped in bins which increase exponentially in size so that a constant fraction of the samples is retained at any point in the sequence. The algorithm is shown to have particular relevance for a class of Monte Carlo sampling problems which includes one characteristic of iterative reconstruction in computed tomography. The code is available in the CPC program library in both Fortran 95 and C and is also available in R through CRAN.

  18. Solar maximum: solar array degradation

    International Nuclear Information System (INIS)

    The 5-year in-orbit power degradation of the silicon solar array aboard the Solar Maximum Satellite was evaluated. This was the first spacecraft to use Teflon R FEP as a coverglass adhesive, thus avoiding the necessity of an ultraviolet filter. The peak power tracking mode of the power regulator unit was employed to ensure consistent maximum power comparisons. Telemetry was normalized to account for the effects of illumination intensity, charged particle irradiation dosage, and solar array temperature. Reference conditions of 1.0 solar constant at air mass zero and 301 K (28 C) were used as a basis for normalization. Beginning-of-life array power was 2230 watts. Currently, the array output is 1830 watts. This corresponds to a 16 percent loss in array performance over 5 years. Comparison of Solar Maximum Telemetry and predicted power levels indicate that array output is 2 percent less than predictions based on an annual 1.0 MeV equivalent election fluence of 2.34 x ten to the 13th power square centimeters space environment

  19. Hemocompatibility of titania nanotube arrays.

    Science.gov (United States)

    Smith, Barbara S; Yoriya, Sorachon; Grissom, Laura; Grimes, Craig A; Popat, Ketul C

    2010-11-01

    Hemocompatibility is a key consideration for the long-term success of blood contacting biomaterials; hence, there is a critical need to understand the physiological response elicited from blood/nano-biomaterial interactions. In this study, we have investigated the adsorption of key blood serum proteins, in vitro adhesion and activation of platelets, and clotting kinetics of whole blood on titania nanotube arrays. Previous studies have demonstrated improved mesenchymal stem cell functionality, osteoblast phenotypic behavior, localized drug delivery, and the production of endothelial cell ECM on titania nanotube arrays. Furthermore, these titania nanotube arrays have elicited minimal levels of monocyte activation and cytokine secretion, thus exhibiting a very low degree of immunogenicity. Titania nanotube arrays were fabricated using anodization technique and the surface morphology was examined through scanning electron microscopy (SEM). The crystalline phases were identified using glancing angled X-ray diffraction (GAXRD). Nanoindentation and scratch tests were used to characterize the mechanical properties of titania nanotube arrays. The adsorption of key blood proteins (albumin, fibrinogen, and immunoglobulin-g) was evaluated using a micro-BCA assay and X-ray photoelectron spectroscopy (XPS). The adhesion and activation of platelets was investigated using live-cell staining, MTT assay, and SEM. Whole blood clotting kinetics was evaluated by measuring the free hemoglobin concentration, and SEM was used to visualize the clot formation. Our results indicate increased blood serum protein adsorption, platelet adhesion and activation, and whole blood clotting kinetics on titania nanotube arrays. PMID:20629021

  20. Optical Transmission Properties of Dielectric Aperture Arrays

    Science.gov (United States)

    Yang, Tao

    units (RIU) and a dynamic range as large as 0.17 RIU. Subsequently, optical transmission properties through a self-mixing interferometer array are studied and a novel high-resolution cost-effective optical spectrometer is proposed. The miniature interferometer-based spectrometer is made of polymethyl methacrylate (PMMA) with a CCD as the detector. The detected intensity of each CCD pixels contains the spectral information. Since each frequency component in the incoming beam corresponds to a unique phase difference of the two beam portions of each optical interferometer, the total intensity received by each CCD pixel, which is resulted from the addition of the interference signals from all the frequency components in the beam, should also be unique. Therefore, the spectrum calculation is a problem to solve an ill-posed linear system by using Tikhonov regularization method. Simulation results show that the resolution can reach picometer level. Apart from the choice of path difference between the interfering beams, the spectral resolution also depends on the signal-to-noise ratio and analogue-digital conversion resolution (dynamic range) of the CCD chip. In addition, the theory of uniform waveguide scattering is explored to expand the possibility of using such mini-interferometers for performing free-space spectral analysis of waveguide devices. At the same time, the method of least squares is used to correct the pixel non-uniformity of the CCD so as to improve the performance of the spectrometer. The sensor chip and spectrometer chip introduced here are based on the interference of light transmitted through dielectric aperture arrays. Their compact feature renders these devices ideal for miniaturization and integration as the systems in microfluidics architectures and lab-on-chip designs.

  1. The Submillimeter Array Antennas and Receivers

    CERN Document Server

    Blundell, R

    2005-01-01

    The Submillimeter Array (SMA) was conceived at the Smithsonian Astrophysical Observatory in 1984 as a six element interferometer to operate in the major atmospheric windows from about 200 to 900 GHz. In 1996, the Academica Sinica Institute of Astronomy and Astrophysics of Taiwan joined the project and agreed to provide additional hardware to expand the interferometer to eight elements. All eight antennas are now operating at the observatory site on Mauna Kea, and astronomical observations have been made in the 230, 345, and 650 GHz bands. The SMA antennas have a diameter of 6 m, a surface accuracy of better than 25 micron rms, and can be reconfigured to provide spatial resolutions down to about 0.5" at 200 GHz and, eventually, 0.1" at 850 GHz. Coupling to the receiver package within each antenna is achieved via a beam waveguide, in a bent Nasmyth configuration, comprised of a flat tertiary mirror and two ellipsoidal mirrors that form a secondary pupil used for receiver calibration. An additional fixed mirror ...

  2. Stability of non compact steady and expanding gradient Ricci solitons

    OpenAIRE

    Deruelle, Alix

    2014-01-01

    We study the stability of non compact steady and expanding gradient Ricci solitons. We first show that strict linear stability implies dynamical stability. Then we give various sufficient geometric conditions ensuring the strict linear stability of such gradient Ricci solitons.

  3. Expandable Cryogenic Tankage for On Orbit Depot Storage Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed expandable depot storage tanks would make it possible to have an on-orbit tank larger in volume than any existing or planned launch vehicles. The size...

  4. Outreach Plan : Sherburne National Wildlife Refuge for Expanded Hunting Opportunities

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Outreach Plan for Sherburne NWR states that hunting opportunities will be expanded on the Refuge to include wild turkey hunting by disabled and youth hunters.

  5. Expanded HIV Screening Projected to Decrease Spread of the Virus

    Science.gov (United States)

    ... Testing Drugs and the Brain Genetics Global Health Hepatitis (Viral) HIV/AIDS Medical Consequences Mental Health Military Pain ... effective for interventions. Text Description of Graphic Early Diagnosis and Treatment “The lack of frequent and expanded ...

  6. Environmental assessment, expanded Ponnequin wind energy project, Weld County, Colorado

    International Nuclear Information System (INIS)

    The US Department of Energy (DOE) has considered a proposal from the State of Colorado, Office of Energy Conservation (OEC), for funding construction of the Expanded Ponnequin Wind Project in Weld County, Colorado. OEC plans to enter into a contracting arrangement with Public Service Company of Colorado (PSCo) for the completion of these activities. PSCo, along with its subcontractors and business partners, are jointly developing the Expanded Ponnequin Wind Project. The purpose of this Final Environmental Assessment (EA) is to provide DOE and the public with information on potential environmental impacts associated with the Expanded Ponnequin Wind Energy Project. This EA, and public comments received on it, were used in DOE's deliberations on whether to release funding for the expanded project under the Commercialization Ventures Program

  7. Dynamical 3-Space: Black Holes in an Expanding Universe

    CERN Document Server

    Rothall, D P

    2013-01-01

    Black holes are usually studied without including effects of the expanding universe. However in some recent studies black holes have been embedded in an expanding universe, in order to determine the interplay, if any, of these two dynamical processes. Dynamical 3-space theory contains time independent solutions for black holes, which are spatial in-flows, and separately the time dependent Hubble expansion. This theory has explained numerous puzzles in observational astrophysics and contains 3 constants; G, alpha - which from experimental data turns out to be the fine structure constant, and delta - which is a small but nonzero distance, possibly a Planck-type length. The Hubble expansion in the dynamical 3-space theory cannot be `switched off', forcing the study, first, of isolated black holes coexisting with the expanding universe. It is shown that a time dependent black hole and expanding universe solution exists. The nature and implications of these solutions are discussed as they evolve over time. A dynam...

  8. Environmental assessment, expanded Ponnequin wind energy project, Weld County, Colorado

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-02-01

    The US Department of Energy (DOE) has considered a proposal from the State of Colorado, Office of Energy Conservation (OEC), for funding construction of the Expanded Ponnequin Wind Project in Weld County, Colorado. OEC plans to enter into a contracting arrangement with Public Service Company of Colorado (PSCo) for the completion of these activities. PSCo, along with its subcontractors and business partners, are jointly developing the Expanded Ponnequin Wind Project. The purpose of this Final Environmental Assessment (EA) is to provide DOE and the public with information on potential environmental impacts associated with the Expanded Ponnequin Wind Energy Project. This EA, and public comments received on it, were used in DOE`s deliberations on whether to release funding for the expanded project under the Commercialization Ventures Program.

  9. Pratt & Whitney expands engineering university partnership with Virginia Tech

    OpenAIRE

    Nystrom, Lynn A.

    2009-01-01

    Pratt and Whitney has expanded its strategic university partnership with Virginia Tech to include research into composite materials. Pratt and Whitney is a United Technologies Corp. (NYSE:UTX) company.

  10. Expanded protein information at SGD: new pages and proteome browser

    OpenAIRE

    Nash, Robert; Weng, Shuai; Hitz, Ben; Balakrishnan, Rama; Christie, Karen R.; Costanzo, Maria C.; Dwight, Selina S.; Engel, Stacia R.; Fisk, Dianna G.; Hirschman, Jodi E.; Hong, Eurie L.; Livstone, Michael S.; Oughtred, Rose; Park, Julie; Skrzypek, Marek

    2006-01-01

    The recent explosion in protein data generated from both directed small-scale studies and large-scale proteomics efforts has greatly expanded the quantity of available protein information and has prompted the Saccharomyces Genome Database (SGD; ) to enhance the depth and accessibility of protein annotations. In particular, we have expanded ongoing efforts to improve the integration of experimental information and sequence-based predictions and have redesigned the protein information web pages...

  11. Functional Self-Expandable Metal Stents in Biliary Obstruction

    OpenAIRE

    Kwon, Chang-Il; Ko, Kwang Hyun; Hahm, Ki Baik; Kang, Dae Hwan

    2013-01-01

    Biliary stents are widely used not only for palliative treatment of malignant biliary obstruction but also for benign biliary diseases. Each plastic stent or self-expandable metal stent (SEMS) has its own advantages, and a proper stent should be selected carefully for individual condition. To compensate and overcome several drawbacks of SEMS, functional self-expandable metal stent (FSEMS) has been developed with much progress so far. This article looks into the outcomes and defects of each st...

  12. Shifted genus expanded W ∞ algebra and shifted Hurwitz numbers

    Science.gov (United States)

    Zheng, Quan

    2016-05-01

    We construct the shifted genus expanded W ∞ algebra, which is isomorphic to the central subalgebra A ∞ of infinite symmetric group algebra and to the shifted Schur symmetrical function algebra Λ* defined by Okounkov and Olshanskii. As an application, we get some differential equations for the generating functions of the shifted Hurwitz numbers; thus, we can express the generating functions in terms of the shifted genus expanded cut-and-join operators.

  13. An expanded prescribing role for pharmacists - an Australian perspective

    OpenAIRE

    Kreshnik Hoti; Jeffery Hughes; Bruce Sunderland

    2011-01-01

    Expanded pharmacist prescribing is a new professional practice area for pharmacists. Currently, Australian pharmacists’ prescribing role is limited to over-the-counter medications. This review aims to identify Australian studies involving the area of expanded pharmacist prescribing. Australian studies exploring the issues of pharmacist prescribing were identified and considered in the context of its implementation internationally. Australian studies have mainly focused on the attitudes of com...

  14. Multitrophic interactions on a range-expanding plant species

    OpenAIRE

    Fortuna, T.F.M.

    2013-01-01

    Studies on the ecological impacts of exotic invasive plants have mainly focused on inter-continental invasions. However due to global environmental changes, a rapid increase in intra-continental range-expanding plants has been observed. In this context, multitrophic interactions between exotic plants, native herbivores and their natural enemies have been largely ignored. This thesis aimed at examining how an exotic range-expanding plant interacts with aboveground insect herbivores and their n...

  15. Genomic studies of expanded trinucleotide repeats : Focus on neuropsychiatric disorders

    OpenAIRE

    Lindblad, Kerstin

    1998-01-01

    In a number of neurological and neuropsychiatric disorders, a worsening of the disease phenotype from one generation to the next has been linked to expanded trinucleotide repeat sequences that increase in size upon transmission. The clinical phenomenon of an earlier age of onset or a more severe phenotype in later generations of a family has been termed anticipation. The focus of this thesis has been to study expanded repeat sequences at the genomic level and to identify new...

  16. Expanded uncertainty in measurements of Geiger-Mueller's counter

    International Nuclear Information System (INIS)

    This paper explains the procedure of obtaining expanded uncertainty in measurement for four types of GM counters with the same counter's tube in cases when the contributors of uncertainties in measurement are cosmic background radiation and induced overvoltage phenomenon. According to experiment and obtained experimental results it is established that uncertainties of influenced random variables depend on technological solution of counter and for that purpose they give different contribution to expanded uncertainty in measurement of applied GM counters

  17. a High-Performance Glucose Biosensor Based on Zno Nanorod Arrays Modified with AU Nanoparticles

    Science.gov (United States)

    Zhang, Gong; Lei, Yang; Yan, Xiaoqin

    2012-08-01

    An amperometric glucose biosensor based on vertically aligned ZnO nanorod (NR) arrays modified with Au nanoparticles (NPs) was constructed in a channel-limited way. Au NPs with diameters in the range of 8-10 nm have been successfully synthesized by photoreduction method and were uniformly loaded onto the surface of ZnO NRs that was hydrothermally deposited on the Fluorine doped SnO2 conductive glass (FTO) via electrostatic self-assembly technique. The morphology and structure of Au/ZnO NR arrays were characterized by field-emission scanning electron microscopy (FE-SEM), high-resolution transmission electron microscopy (HRTEM) and X-ray photoelectron spectrum analyzer (XPS). The electrocatalytic properties of glucose oxidase (GOD)- immobilized Au/ZnO NR arrays were evaluated by amperometry. Compared with the biosensor based on ZnO NR arrays, the resulting Au/ZnO NR arrays modified biosensor exhibited an expanded linear range from 3 μM to 3 mM with the detection limit of 30 nM and a smaller Michaelis-Menten constant of 0.7836 mM. All these results suggest that the Au NPs can greatly improve the biosensing properties of ZnO NR arrays and therefore Au/ZnO NR arrays provide a promising material for the biosensor designs and other biological applications.

  18. The effect of tissue expanders on the growing craniofacial skeleton

    Directory of Open Access Journals (Sweden)

    Awad Mohamed

    2006-01-01

    Full Text Available Background: Tissue expansion can safely be considered one of the major advances in reconstructive plastic surgery. Reported complication rates for tissue expansion have been as low as zero and as high as 48% when expanding the head and neck region in pediatric patients.[1] Our study is to discuss the osseous effects during and after tissue expansion in children. Materials and Methods: Thirty four expanders were implanted, 30 in scalp and 4 in face. In 4 patients, 2 expanders were used. The mean age of the patients was 3.8 years. All CT examinations (pre-expansion, post-expansion and after reconstruction were done correspondingly with each other to be able to compare the following parameters: bone thickness and bone density under the expander; certain intracranial dimensions under the center and the edge of the expander and observing the contour of the skull in the 3D reconstruction. Results: Variable bony changes were observed in the 30 patients, apposition at the edge of expander (Periosteal reaction being the most frequent change, which was observed in, all except 3 patients. Bone resorption and thinning occurred in 9 patients. Inward bone displacement varied from 1 to 3 mm in two patients. Conclusions: In spite of the reported complications like thinning and deformation of underlying bone, expansion in infants and children is safe if done with a proper preoperative planning and we prefer to delay the expansion after two years as possible.

  19. A Novel Approach to Beam Steering Using Arrays Composed of Multiple Unique Radiating Modes

    Science.gov (United States)

    Labadie, Nathan Richard

    Phased array antennas have found wide application in both radar and wireless communications systems particularly as implementation costs continue to decrease. The primary advantages of electronically scanned arrays are speed of beam scan and versatility of beamforming compared to mechanically scanned fixed beam antennas. These benefits come at the cost of a few well known design issues including element pattern rolloff and mutual coupling between elements. Our primary contribution to the field of research is the demonstration of significant improvement in phased array scan performance using multiple unique radiating modes. In short, orthogonal radiating modes have minimal coupling by definition and can also be generated with reduced rolloff at wide scan angles. In this dissertation, we present a combination of analysis, full-wave electromagnetic simulation and measured data to support our claims. The novel folded ring resonator (FRR) antenna is introduced as a wideband and multi-band element embedded in a grounded dielectric substrate. Multiple radiating modes of a small ground plane excited by a four element FRR array were also investigated. A novel hemispherical null steering antenna composed of two collocated radiating elements, each supporting a unique radiating mode, is presented in the context of an anti-jam GPS receiver application. Both the antenna aperture and active feed network were fabricated and measured showing excellent agreement with analytical and simulated data. The concept of using an antenna supporting multiple radiating modes for beam steering is also explored. A 16 element hybrid linear phased array was fabricated and measured demonstrating significantly improved scan range and scanned gain compared to a conventional phased array. This idea is expanded to 2 dimensional scanning arrays by analysis and simulation of a hybrid phased array composed of novel multiple mode monopole on patch antenna sub-arrays. Finally, we fabricated and

  20. Instrumentation for multi-detector arrays

    Indian Academy of Sciences (India)

    R K Bhowmik

    2001-07-01

    The new generation of detector arrays require complex instrumentation and data acquisition system to ensure increased reliability of operation, high degree of integration, software control and faster data handling capability. The main features of some of the existing multi-detector arrays like MSU 4 array, Gammasphere and Eurogam are summarized. The instrumentation for the proposed INGA array in India is discussed.

  1. Retrieval of Mir Solar Array

    Science.gov (United States)

    Rutledge, Sharon K.; deGroh, Kim K.

    1999-01-01

    A Russian solar array panel removed in November 1997 from the non-articulating photovoltaic array on the Mir core module was returned to Earth on STS-89 in January 1998. The panel had been exposed to low Earth orbit (LEO) for 10 years prior to retrieval. The retrieval provided a unique opportunity to study the effects of the LEO environment on a functional solar array. To take advantage of this opportunity, a team composed of members from RSC-Energia (Russia), the Boeing Company, and the following NASA Centers--Johnson Space Center, Kennedy Space Center, Langley Research Center, Marshall Space Flight Center, and Lewis Research Center--was put together to analyze the array. After post-retrieval inspections at the Spacehab Facility at Kennedy in Florida, the array was shipped to Lewis in Cleveland for electrical performance tests, closeup photodocumentation, and removal of selected solar cells and blanket material. With approval from RSC-Energia, five cell pairs and their accompanying blanket and mesh material, and samples of painted handrail materials were selected for removal on the basis of their ability to provide degradation information. Sites were selected that provided different sizes and shapes of micrometeoroid impacts and different levels of surface contamination. These materials were then distributed among the team for round robin testing.

  2. Integrated Array/Metadata Analytics

    Science.gov (United States)

    Misev, Dimitar; Baumann, Peter

    2015-04-01

    Data comes in various forms and types, and integration usually presents a problem that is often simply ignored and solved with ad-hoc solutions. Multidimensional arrays are an ubiquitous data type, that we find at the core of virtually all science and engineering domains, as sensor, model, image, statistics data. Naturally, arrays are richly described by and intertwined with additional metadata (alphanumeric relational data, XML, JSON, etc). Database systems, however, a fundamental building block of what we call "Big Data", lack adequate support for modelling and expressing these array data/metadata relationships. Array analytics is hence quite primitive or non-existent at all in modern relational DBMS. Recognizing this, we extended SQL with a new SQL/MDA part seamlessly integrating multidimensional array analytics into the standard database query language. We demonstrate the benefits of SQL/MDA with real-world examples executed in ASQLDB, an open-source mediator system based on HSQLDB and rasdaman, that already implements SQL/MDA.

  3. Solid-state array cameras.

    Science.gov (United States)

    Strull, G; List, W F; Irwin, E L; Farnsworth, D L

    1972-05-01

    Over the past few years there has been growing interest shown in the rapidly maturing technology of totally solid-state imaging. This paper presents a synopsis of developments made in this field at the Westinghouse ATL facilities with emphasis on row-column organized monolithic arrays of diffused junction phototransistors. The complete processing sequence applicable to the fabrication of modern highdensity arrays is described from wafer ingot preparation to final sensor testing. Special steps found necessary for high yield processing, such as surface etching prior to both sawing and lapping, are discussed along with the rationale behind their adoption. Camera systems built around matrix array photosensors are presented in a historical time-wise progression beginning with the first 50 x 50 element converter developed in 1965 and running through the most recent 400 x 500 element system delivered in 1972. The freedom of mechanical architecture made available to system designers by solid-state array cameras is noted from the description of a bare-chip packaged cubic inch camera. Hybrid scan systems employing one-dimensional line arrays are cited, and the basic tradeoffs to their use are listed. PMID:20119094

  4. Successive Standardization of Rectangular Arrays

    Directory of Open Access Journals (Sweden)

    Richard A. Olshen

    2012-02-01

    Full Text Available In this note we illustrate and develop further with mathematics and examples, the work on successive standardization (or normalization that is studied earlier by the same authors in [1] and [2]. Thus, we deal with successive iterations applied to rectangular arrays of numbers, where to avoid technical difficulties an array has at least three rows and at least three columns. Without loss, an iteration begins with operations on columns: first subtract the mean of each column; then divide by its standard deviation. The iteration continues with the same two operations done successively for rows. These four operations applied in sequence completes one iteration. One then iterates again, and again, and again, ... In [1] it was argued that if arrays are made up of real numbers, then the set for which convergence of these successive iterations fails has Lebesgue measure 0. The limiting array has row and column means 0, row and column standard deviations 1. A basic result on convergence given in [1] is true, though the argument in [1] is faulty. The result is stated in the form of a theorem here, and the argument for the theorem is correct. Moreover, many graphics given in [1] suggest that except for a set of entries of any array with Lebesgue measure 0, convergence is very rapid, eventually exponentially fast in the number of iterations. Because we learned this set of rules from Bradley Efron, we call it “Efron’s algorithm”. More importantly, the rapidity of convergence is illustrated by numerical examples.

  5. Wavenumber response of Shanghai Seismic Array

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@Seismic array can be traced back to 1950s when it mainly aimed at detecting and distinguishing the signals of nuclear explosion and seismic signals. The research on seismic array includes seismic array techniques and applications of array in geophysics. Array techniques involve array design and data processing methods (Anne, 1990). Nowadays, the continuous development of seismic array¢s theory could relate to many scientific issues in geophysical field (Tormod, 1989; Mykkeltveit, Bungum, 1984). Seismic array is mainly applied to detect weak events. The response characteristic of array is an important indication of array¢s detection ability. Therefore, when we study an array or construct an array, one of the neces-sary works is to calculate the response characteristics of the array (Harjes, 1990). The aperture and layout of array are two dominating geometrical features. The typical aperture of interna-tional array is generally from several to tens kilometers. For instance, arrays with aperture of dozens kilometers aperture are KSA, WRA, YKA, etc, while arrays with several kilometer aperture are ARC, FIN, GEE, etc. Moreo-ver, in the view of array¢s layout, NOR, GER, etc have circle layout, while WRA, YKA, etc have decussating layout. This paper mainly discusses the relation between deployment of array and wavenumber response. With the example of constructing Shanghai Seismic Array, this paper provides one practical solution to search the proper array deployment. In this paper, the simple delay beam technique is adopted to calculate the response characteris-tics of array. Certainly, the different processing methods have different result, but the result from the simple delay beam processing could be enough to reflect the feature of an array.

  6. Distributed Phased Arrays and Wireless Beamforming Networks

    OpenAIRE

    David Jenn; Yong Loke; Tong Chin Hong Matthew; Yeo Eng Choon; Ong Chin Siang; Yeo Siew Yam

    2009-01-01

    Distributed phased arrays have advantages over conventional arrays in many radar and communication applications. Additional advantages are realized by replacing the microwave beamforming circuit by a wireless network, thus forming a wirelessly networked distributed sensor array. This article examines various aspects of a distributed phased array that incorporates wireless beamforming. First, the fundamental array theory and digital signal processing are reviewed. Basic equations are presented...

  7. Mathematical Simulating Model of Phased-Array Antenna in Multifunction Array Radar

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    A mathematical simulating model of phased-array antenna in multifunction array radar has been approached in this paper, including the mathematical simulating model of plane phased-array pattern, the mathematical simulating model of directionality factor, the mathematical simulating model of array factor, the mathematical simulating model of array element factor and the mathematical simulating model of beam steering.

  8. Sensitivity of Pulsar Timing Arrays

    Science.gov (United States)

    Siemens, Xavier

    2015-08-01

    For the better part of the last decade, the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) has been using the Green Bank and Arecibo radio telescopes to monitor millisecond pulsars. NANOGrav, along with similar international collaborations, the European Pulsar Timing Array and the Parkes Pulsar Timing Array in Australia, form a consortium of consortia: the International Pulsar Timing Array (IPTA). The goal of the IPTA is to directly detect low-frequency gravitational waves which cause small changes to the times of arrival of radio pulses from millisecond pulsars. In this talk I will discuss the work of NANOGrav and the IPTA as well as our sensitivity to gravitational waves from astrophysical sources. I will show that a detection is possible by the end of the decade.

  9. Thin, Flexible IMM Solar Array

    Science.gov (United States)

    Walmsley, Nicholas

    2015-01-01

    NASA needs solar arrays that are thin, flexible, and highly efficient; package compactly for launch; and deploy into large, structurally stable high-power generators. Inverted metamorphic multijunction (IMM) solar cells can enable these arrays, but integration of this thin crystalline cell technology presents certain challenges. The Thin Hybrid Interconnected Solar Array (THINS) technology allows robust and reliable integration of IMM cells into a flexible blanket comprising standardized modules engineered for easy production. The modules support the IMM cell by using multifunctional materials for structural stability, shielding, coefficient of thermal expansion (CTE) stress relief, and integrated thermal and electrical functions. The design approach includes total encapsulation, which benefits high voltage as well as electrostatic performance.

  10. Coherent magnetic semiconductor nanodot arrays

    Directory of Open Access Journals (Sweden)

    Xiu Faxian

    2011-01-01

    Full Text Available Abstract In searching appropriate candidates of magnetic semiconductors compatible with mainstream Si technology for future spintronic devices, extensive attention has been focused on Mn-doped Ge magnetic semiconductors. Up to now, lack of reliable methods to obtain high-quality MnGe nanostructures with a desired shape and a good controllability has been a barrier to make these materials practically applicable for spintronic devices. Here, we report, for the first time, an innovative growth approach to produce self-assembled and coherent magnetic MnGe nanodot arrays with an excellent reproducibility. Magnetotransport experiments reveal that the nanodot arrays possess giant magneto-resistance associated with geometrical effects. The discovery of the MnGe nanodot arrays paves the way towards next-generation high-density magnetic memories and spintronic devices with low-power dissipation.

  11. Space-Based Tethered Array Radar (STAR) - A Distributed Small Satellite Network

    OpenAIRE

    Tomlinson, Philip; Brown, Thomas; Chakraborty, Dayamoy

    1988-01-01

    The Space-Based Tethered Array Radar (STAR) concept evolved from the DoD need for an affordable, launchable, survivable, and expandable Space-Based Radar for wide-area surveillance of airborne targets and for ballistic missile defense applications. Because low-observable threats can undermine conventional large monolithic Space-Based Radar satellite designs by forcing power-aperture products (inversely proportional to target radar cross-section) so high that the resulting heavy and expensive ...

  12. Small satellite solar array substrate

    Science.gov (United States)

    Fiore, John N.; Rosanova, Giulio

    1994-01-01

    The SMall EXplorer (SMEX) Fast Auroral SnapshoT (FAST) spacecraft was developed to investigate plasma physics of auroral phenomena at high orbital altitude. The FAST satellite comprises a variety of deployable booms with sensors on the ends, and instruments that protrude from the main body of the spacecraft to obtain the plasma and electromagnetic fields data. This required the plasma disturbance around the satellite to be kept to a minimum. A non deployable, body mounted solar array was implemented. This led to the design of a light weight solar array substrate with a high degree of structural integrity.

  13. TV-SAT solar array

    Energy Technology Data Exchange (ETDEWEB)

    Urbain, G.; Rinn, C.; Bastard, J.L.

    1982-06-01

    The electrical and mechanical performance of the TV-SAT direct television broadcasting satellite is described. The 4.5 kW end of life 7.5yr array contains 43,200 back surface reflector solar cells. The first, 3.1 kW, array consists of two identical wings, providing power during transfer and geostationary orbit. Each wing is made up of four carbon fiber panels. The outboard panel of each wing is deployed at 90 deg in transfer orbit, during which the satellite is three axis stabilized.

  14. Future Plans of Telescope Array

    International Nuclear Information System (INIS)

    The Telescope Array (TA) experiment is the only ultra high energy cosmic ray observatory in the northern hemisphere. In addition, it will be the world's first air shower detector to be directly calibrated by an on-site accelerator beam. For wider and deeper understanding of cosmic rays by via high precision measurements, we have undertaken the study of extension plans for TA. One extension plan will extend the sensitive energy range of TA down to 1017 eV. A second plan would extend of the aperture area of the SD array. These plans are described in this note.

  15. Substrate integrated antennas and arrays

    CERN Document Server

    Cheng, Yu Jian

    2015-01-01

    Substrate Integrated Antennas and Arrays provides a single source for cutting-edge information on substrate integrated circuits (SICs), substrate integrated waveguide (SIW) feeding networks, SIW slot array antennas, SIC traveling-wave antennas, SIW feeding antennas, SIW monopulse antennas, and SIW multibeam antennas. Inspired by the author's extensive research, this comprehensive book:Describes a revolutionary SIC-based antenna technique with the potential to replace existing antenna technologiesExamines theoretical and experimental results connected to electrical and mechanical performanceExp

  16. Phased arrays: inline flow line hub inspection using phased arrays

    NARCIS (Netherlands)

    Bloom, J.G.P.; Chougrani, K.; Rundberg, H.; Oldenziel, G.; Deleye, X.; Martina, Q.

    2011-01-01

    The feasibility of the inspection of flow line hubs using the phased array technique was investigated to determine the surface area of the seal area degraded by corrosion. A clean model of the hub was simulated to gain insight into the geometrical echoes and to determine the area covered by the ultr

  17. Numerical simulation of a twin screw expander for performance prediction

    Science.gov (United States)

    Papes, Iva; Degroote, Joris; Vierendeels, Jan

    2015-08-01

    With the increasing use of twin screw expanders in waste heat recovery applications, the performance prediction of these machines plays an important role. This paper presents a mathematical model for calculating the performance of a twin screw expander. From the mass and energy conservation laws, differential equations are derived which are then solved together with the appropriate Equation of State in the instantaneous control volumes. Different flow processes that occur inside the screw expander such as filling (accompanied by a substantial pressure loss) and leakage flows through the clearances are accounted for in the model. The mathematical model employs all geometrical parameters such as chamber volume, suction and leakage areas. With R245fa as working fluid, the Aungier Redlich-Kwong Equation of State has been used in order to include real gas effects. To calculate the mass flow rates through the leakage paths formed inside the screw expander, flow coefficients are considered as constant and they are derived from 3D Computational Fluid Dynamic calculations at given working conditions and applied to all other working conditions. The outcome of the mathematical model is the P-V indicator diagram which is compared to CFD results of the same twin screw expander. Since CFD calculations require significant computational time, developed mathematical model can be used for the faster performance prediction.

  18. Expanded tenses in the old English orosius a syntactic strengthening*

    Directory of Open Access Journals (Sweden)

    Frančiška Trobevšek Drobnak

    2015-12-01

    Full Text Available The present chapter reports the investigation into certain aspects of the periphrastic construction to be +present participle (e.g. NE: "he is teaching"; OE. "he is laerende" viewed as an example of a syntactic strengthening. The construc­ tion is usually referred to as "continuous tenses/form" or "progressive tenses/form", whereas Nickel (1966 uses "expanded form". Coming closest to this latter term, the "expanded tenses" employed here seems a convenient label for two reasons: a  the use of expanded tenses is not restricted to the expression of verbal aspect (Aspekt or mode of verbal action (Aktionsart, which is implied by the use of either the term "continuous  tenses/form" or the term "progressive tenses/form"; b  the expanded tenses are integrated into the English tense system, in the sense that they can be substituted  with the respective non-expanded tenses without any change in the syntax of the clause, e.g.

  19. The technique of sand control with expandable screens

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, P. [Petrochina, Liaohe (China). Liaohe Oilfield Co.

    2009-07-01

    Sand production in heavy oil reservoirs can limit the normal production of oil wells. In this study, expandable screens were used as a sand control mechanism by filtering the sand as it entered the wellbore. The screen systems consists of an expandable outer housing, an expandable base pipe and a filtering layer. The screen expands radially through an expandable cone and presses into the casing well. Axial tension is used to shrink the screens radially through a fishing anchor in order to remove them from the well. The lack of a sand ring between the screen and the casing increases the flow area of the oil and reduces flow resistance caused by fine silt blockages. A series of laboratory experiments were conducted to study the expansion and shrinkage properties of the screens. A field test conducted at a well located in the Liaohe oilfield in China demonstrated that good sand control results can be obtained without the need for pump checking. It was concluded that the sand control method is easy to use and provides good sand control results in large open flow areas. 2 refs., 2 tabs., 3 figs.

  20. An Expanded CAG Repeat in Huntingtin Causes +1 Frameshifting.

    Science.gov (United States)

    Saffert, Paul; Adamla, Frauke; Schieweck, Rico; Atkins, John F; Ignatova, Zoya

    2016-08-26

    Maintenance of triplet decoding is crucial for the expression of functional protein because deviations either into the -1 or +1 reading frames are often non-functional. We report here that expression of huntingtin (Htt) exon 1 with expanded CAG repeats, implicated in Huntington pathology, undergoes a sporadic +1 frameshift to generate from the CAG repeat a trans-frame AGC repeat-encoded product. This +1 recoding is exclusively detected in pathological Htt variants, i.e. those with expanded repeats with more than 35 consecutive CAG codons. An atypical +1 shift site, UUC C at the 5' end of CAG repeats, which has some resemblance to the influenza A virus shift site, triggers the +1 frameshifting and is enhanced by the increased propensity of the expanded CAG repeats to form a stem-loop structure. The +1 trans-frame-encoded product can directly influence the aggregation of the parental Htt exon 1. PMID:27382061

  1. Expandable Total Humeral Replacement in a Child with Osteosarcoma

    Directory of Open Access Journals (Sweden)

    Eric R. Henderson

    2015-01-01

    Full Text Available Case. A right-handed 8-year-old female patient presented with a conventional, high-grade osteosarcoma involving her right humerus; through-shoulder amputation was recommended. After consultation, total humerus resection with expandable, total humeral endoprosthesis reconstruction was performed with a sleeve to encourage soft-tissue ingrowth. At three-year follow-up she has received one lengthening procedure and her functional scores are excellent. Conclusion. Total humeral resection and replacement in the pediatric population are rare and although early reports of expandable total humeral endoprosthesis outcomes demonstrate high failure rates, this patient’s success indicates that expandable total humeral replacement is a viable option.

  2. Expanded bed adsorption of an alkaline lipase from Pseudomona cepacia.

    Science.gov (United States)

    da Silva Padilha, Giovana; Curvelo-Santana, José Carlos; Alegre, Ranulfo Monte; Tambourgi, Elias Basile

    2009-02-15

    An extracellular lipase was isolated from Pseudomona cepacia by expanded bed adsorption on an Amberlite 410 ion-exchange resin. Enzyme characterization and hydrodynamic study of a chromatography column were done. Enzyme purification was done at three condition of expanded bed height (H): at one and half (6cm), at two (8cm) and at three (12cm) times the fixed bed height (H(0)=4cm). The results showed that the experimental data was fitted to the Richardson and Zaki equation, and the comparison between the experimental and calculated terminal velocities showed low relative error. In enzyme purification for better condition, a purification factor of about 80 times was found at 6cm of expanded bed height, or 1.5 times of expansion degree. Purified lipase had an optimal pH and a temperature of 8 and 37 degrees C, respectively. PMID:19162572

  3. Sea Level Enigmatic Rising - New Perspectives from an Expanding Globe

    CERN Document Server

    Scalera, Giancarlo

    2015-01-01

    In the expanding Earth framework it is possible to find additional phenomena that could contribute in a proper way to the water balance and general tectonic eustatism involved in the sea lever rising. Recent compilations seems to leave unexplained up to 12 cm/century of sea rising, and possible solutions invoking a polar ice shells melting near to the upper limit of the error bars reveal in conflict with the consequent expected decreasing of the Earth angular velocity. It is shown that taking into account possible effects of an expanding Earth, the problem can be initiated towards an appropriate solution, at least as regards the just orders of magnitude. Major effects on sea-level could come from ongoing relaxation of curvature variations that are peculiar for an expanding globe.

  4. Characteristic mechanical properties of balloon-expandable peripheral stent systems

    International Nuclear Information System (INIS)

    Purpose: To measure in vitro geometric-mechanical characteristics of balloon-expandable peripheral stent systems for determining suitability for specific vascular regions. Materials and Methods: Balloon-expandable stents including their delivery systems manufactured by Guidant (OTW MegalinkTM), Inflow Dynamics (Antares), Medtronic (AVE BridgeTM), Biotronik (PeironTM) and Cordis (Corinthian IQTM) were selected for this study. When expanded, all stents had a nominal diameter of 8 mm. The length was 38-40 mm. Stent profile, trackability, length change on expansion, stiffness, elastic recoil, and radio-opacity in the crimped and expanded state of these stent systems were determined with specially developed test methods. Results: The Corinthian IQTM, MegalinkTM and PeironTM required the smallest force to pass through the vascular model. While the BridgeTM system had the largest profile with a diameter of 2.430 mm, all other stent systems had a significantly smaller diameter ranging from 1.970 mm for the PeironTM to 2.078 mm for the Corinthian IQTM. In the distal region of the stent delivery system, the MegalinkTM was the most flexible and the BridgeTM system the stiffest. Elastic recoil for all stents was in the range of 2.5% to 3.5%, with the exception of the BridgeTM stent, which had an elastic recoil of 4.79%. The Corinthian IQTM stent had noticeably the highest radial stiffness. In the expanded condition, the PeironTM was the most flexible while the Corinthian IQTM and AntaresTM were found to be the stiffest. Length change (shrinkage on expansion) ranged from 0.54 to 6.57%, with the exception of the Corinthian IQ, which shrunk >7 mm (18.5%) on expansion. All stent systems in the crimped and expanded state were readily visible radiographically. (orig.)

  5. Expanded applications for high performance VOx microbolometer FPAs

    Science.gov (United States)

    Murphy, D.; Ray, M.; Kennedy, A.; Wyles, J.; Hewitt, C.; Wyles, R.; Gordon, E.; Sessler, T.; Baur, S.; Van Lue, D.; Anderson, S.; Chin, R.; Gonzalez, H.; Le Pere, C.; Ton, S.; Kostrzewa, T.

    2005-05-01

    RVS is producing high-quality microbolometer FPAs with 25 μm pixels. We have developed formats in both 320 x 240 and 640 x 480 array formats. These FPAs have demonstrated sensitivities that are comparable to microbolometer FPAs with 50 μm pixels with the best measured NETD value for these FPAs now <25mK with an f/1 aperture and operating at 30 Hz frame rates. Pixel operability is greater than 99.9% on most FPAs, and uncorrected responsivity nonuniformity is less than 3% (sigma/mean). These 25 μm microbolometer detectors also have a relatively fast thermal time constant of approximately 10 msec. These arrays have produced excellent image quality, and are currently fielded in a variety of systems. We will report on our latest performance data and IR captive flight test imagery. We will also show data on 25μm arrays that have been designed for faster time constants (5 msec), while maintaining high performance. RVS is also developing a 320 x 240 50μm mid-wave responding FPA. We will review the MWIR sensitivity improvements with this array and provide IR imagery. RVS is developing a 640 x 480 25μm uncooled FPA for a countermine detection application using a two-band assembly designed to be sensitive in both the Restrahlen and Thermal spectral bands. We will provide IR image data on these arrays. RVS has made a significant breakthrough in the development of a 640 x 512 array with a unit cell size of 20 μm x 20 μm, and performance approaching that of the 25μm arrays. The successful development of this array is the first step in achieving mega-pixel formats. This FPA is designed to ultimately achieve performance near the temperature fluxuation limited NETD (<20mK, f/1, 30 Hz). We will show updated performance and imagery on these arrays, which is currently being measured at <45mK, f/1, 30 Hz.

  6. Directivity of basic linear arrays

    DEFF Research Database (Denmark)

    Bach, Henning

    1970-01-01

    For a linear uniform array ofnelements, an expression is derived for the directivity as a function of the spacing and the phase constants. The cases of isotropic elements, collinear short dipoles, and parallel short dipoles are included. The formula obtained is discussed in some detail and contour...

  7. Radar techniques using array antennas

    CERN Document Server

    Wirth, Wulf-Dieter

    2001-01-01

    This book gives an introduction to the possibilities of radar technology based on active array antennas, giving examples of modern practical systems. There are many valuable lessons presented for designers of future high standard multifunction radar systems for military and civil applications. The book will appeal to graduate level engineers, researchers, and managers in the field of radar, aviation and space technology.

  8. Photoelectrochemistry of Semiconductor Nanowire Arrays

    Energy Technology Data Exchange (ETDEWEB)

    Mallouk, Thomas E; Redwing, Joan M

    2009-11-10

    This project supported research on the growth and photoelectrochemical characterization of semiconductor nanowire arrays, and on the development of catalytic materials for visible light water splitting to produce hydrogen and oxygen. Silicon nanowires were grown in the pores of anodic aluminum oxide films by the vapor-liquid-solid technique and were characterized electrochemically. Because adventitious doping from the membrane led to high dark currents, silicon nanowire arrays were then grown on silicon substrates. The dependence of the dark current and photovoltage on preparation techniques, wire diameter, and defect density was studied for both p-silicon and p-indium phosphide nanowire arrays. The open circuit photovoltage of liquid junction cells increased with increasing wire diameter, reaching 350 mV for micron-diameter silicon wires. Liquid junction and radial p-n junction solar cells were fabricated from silicon nano- and microwire arrays and tested. Iridium oxide cluster catalysts stabilized by bidentate malonate and succinate ligands were also made and studied for the water oxidation reaction. Highlights of this project included the first papers on silicon and indium phosphide nanowire solar cells, and a new procedure for making ligand-stabilized water oxidation catalysts that can be covalently linked to molecular photosensitizers or electrode surfaces.

  9. Quantum Entanglement in Nanocavity Arrays

    OpenAIRE

    Liew, T.C.H.; Savona, V

    2011-01-01

    We show theoretically how quantum interference between linearly coupled modes with weak local nonlinearity allows the generation of continuous variable entanglement. By solving the quantum master equation for the density matrix, we show how the entanglement survives realistic levels of pure dephasing. The generation mechanism forms a new paradigm for entanglement generation in arrays of coupled quantum modes.

  10. BOLOMETRIC ARRAYS FOR MILLIMETER WAVELENGTHS

    Directory of Open Access Journals (Sweden)

    E. Castillo

    2009-01-01

    Full Text Available During last years, semiconductor bolometers using thin lms have been developed at INAOE, speci cally boron-doped hydrogenated amorphous silicon lms. The characteristics shown by these devices made them attractive to be used in astronomical instrumentation, mainly in two-dimentional arrays. These detector arrays used at the Large Millimeter Telescope will make possible to obtain astronomical images in millimeter and submillimeter wavelengths. With this in mind, we are developing a method to produce, with enough reliability, bolometer arrays at INAOE. Until now, silicon nitride diaphragm arrays, useful as radiation absorbers, have succesfully been obtained. Sizes going from one to four millimeter by element in a consistent way; however we have not tested thermometers and metallic contact deposition yet. At the same time, we are working on two possible con gurations for the readout electronics; one of them using commercial components while the other will be an integrated circuit speci cally designed for this application. Both versions will work below 77K.

  11. Uniformly expanding vacuum: A possible interpretation of the dark energy

    Science.gov (United States)

    Huang, Peng; Yuan, Fang-Fang

    2016-06-01

    Following the spirit of the equivalence principle, we take a step further to recognize the free fall of the observer as a method to eliminate causes that would lead the perceived vacuum to change its original state. Thus, it is expected that the vacuum should be in a rigid Minkowski state or be uniformly expanding. By carefully investigating the impact on measurement caused by the expansion, we clarify the exact meaning of the uniformly expanding vacuum and find that this proposal may be able to explain the current observations of an accelerating universe.

  12. Hydrodynamic behavior in expanding thermal clouds of 87Rb

    International Nuclear Information System (INIS)

    We study hydrodynamic behavior in expanding thermal clouds of 87Rb released from an elongated trap. At our highest densities the mean free path is smaller than the radial size of the cloud. After release the clouds expand anisotropically. The cloud temperature drops by as much as 30%. This is attributed to isentropic cooling during the early stages of the expansion. We present an analytical model to describe the expansion and to estimate the cooling. Important consequences for time-of-flight thermometry are discussed

  13. The osmotic tissue expander: a three-year clinical experience.

    Science.gov (United States)

    Obdeijn, Miryam C; Nicolai, Jean-Philippe A; Werker, Paul M N

    2009-09-01

    Closure of defects after trauma or excision of neoplasms is a basic skill in plastic surgery. Local, regional and distant flaps lead to additional scars. Skin recruitment by serial excision or skin expansion is a less damaging option for defects that must be closed. Advantages of tissue expansion include good colour and texture match. Disadvantages are the need for a second operation, use of an implant with the attendant risk of infection, time needed for inflation of the device, repeat visits to the clinic, and punctures to inflate the expander. To overcome the last disadvantage, an osmotic expander was developed in Germany in 1999 by OSMED GmbH (Ilmenau). PMID:18755643

  14. Short Rayleigh Length Free Electron Laser Simulations in Expanding Coordinates

    CERN Document Server

    Armstead, Robert L; Colson, William B

    2004-01-01

    For compact short-Rayleigh length FELs, the area of the optical beam can be thousands of times greater at the mirrors than at the beam waist. A fixed numerical grid of sufficient resolution to represent the narrow mode at the waist and the broad mode at the mirrors would be prohibitively large. To accommodate this extreme change of scale with no loss of information, we employ a coordinate system that expands with the diffracting optical mode. The simulation using the new expanding coordinates has been validated by comparison to analytical cold-cavity theory, and is now used to simulate short-Rayleigh length FELs.

  15. The paradox of HIV/AIDS as expanding consciousness.

    Science.gov (United States)

    Lamendola, F P; Newman, M A

    1994-03-01

    A heuristic approach employing Newman's method for pattern identification was used to examine the theory of health as expanding consciousness in persons with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). Themes derived from the interview of nine gay men portrayed a pattern of alienation during childhood, followed by a breaking away from family, and progressing to cycles of aloneness and searching. Recognition of HIV/AIDS in their lives brought them to a turning point of more meaningful connectedness. This pattern is viewed as expanding consciousness and possibly a phenomenon of cultural evolution. PMID:8203827

  16. Phased array antennas with optimized element patterns

    CERN Document Server

    Skobelev, Sergei P

    2011-01-01

    This authoritative resource provides you with a detailed description of ideal array element characteristics that help you estimate the quality of development of real-world phased array antennas. You find several approaches to optimum phased array design, allowing you to provide specified array gain in a specific region of scan, using a minimum number of expensive, controlled devices. Moreover, this practical book presents important numerical methods that you can use to model and optimize phased array structure to obtain the best array characteristics that the chosen structure can provide.From

  17. Variable gearing in a biologically inspired pneumatic actuator array

    International Nuclear Information System (INIS)

    A fundamental feature of pennate muscles is that muscle fibers are oriented at an angle to the line of action and rotate as they shorten, becoming more oblique throughout a contraction. This change in fiber orientation (pennation angle) can amplify the shortening velocity of a fiber and increase output velocity of the muscle. The velocity advantage resulting from dynamic changes in pennation angle can be characterized as a gear ratio (muscle velocity/fiber velocity). A recent study has shown that a pennate muscle's gear ratio varies automatically depending on the load such that a muscle operates with a high gear during rapid contractions and low gear during forceful contractions. We examined whether this variable gearing behavior can be replicated in a pennate array of artificial muscles. We used McKibben type pneumatic actuators, which shorten in tension when filled with compressed gas. Similar to muscle fibers, the actuators expand radially during shortening, a feature thought to be a critical part of the variable gearing mechanism in pennate muscles. We arranged McKibben actuators in an array oriented to mimic a pennate muscle, and quantified the system's gear ratio during contraction against a range of loads. Video was used to measure the gear ratio during each contraction. We find that similar to pennate muscles, the gear ratio decreases significantly with increasing load and that variable gearing results from load-dependent variation in the amount of actuator rotation. These results support the idea that variable gearing in pennate muscles is mediated by difference is fiber rotation and the direction of muscle bulging. The behavior of our artificial muscle array also highlights the potential benefits of bio-inspired architectures in artificial muscle arrays, including the ability to vary force and speed automatically in response to variable loading conditions. (paper)

  18. A Comparative Proteomic Analysis of the Buds and the Young Expanding Leaves of the Tea Plant (Camellia sinensis L.

    Directory of Open Access Journals (Sweden)

    Qin Li

    2015-06-01

    Full Text Available Tea (Camellia sinensis L. is a perennial woody plant that is widely cultivated to produce a popular non-alcoholic beverage; this beverage has received much attention due to its pleasant flavor and bioactive ingredients, particularly several important secondary metabolites. Due to the significant changes in the metabolite contents of the buds and the young expanding leaves of tea plants, high-performance liquid chromatography (HPLC analysis and isobaric tags for relative and absolute quantitation (iTRAQ analysis were performed. A total of 233 differentially expressed proteins were identified. Among these, 116 proteins were up-regulated and 117 proteins were down-regulated in the young expanding leaves compared with the buds. A large array of diverse functions was revealed, including roles in energy and carbohydrate metabolism, secondary metabolite metabolism, nucleic acid and protein metabolism, and photosynthesis- and defense-related processes. These results suggest that polyphenol biosynthesis- and photosynthesis-related proteins regulate the secondary metabolite content of tea plants. The energy and antioxidant metabolism-related proteins may promote tea leaf development. However, reverse transcription quantitative real-time PCR (RT-qPCR showed that the protein expression levels were not well correlated with the gene expression levels. These findings improve our understanding of the molecular mechanism of the changes in the metabolite content of the buds and the young expanding leaves of tea plants.

  19. Cross-platform comparison of SYBR® Green real-time PCR with TaqMan PCR, microarrays and other gene expression measurement technologies evaluated in the MicroArray Quality Control (MAQC study

    Directory of Open Access Journals (Sweden)

    Dial Stacey L

    2008-07-01

    Full Text Available Abstract Background The MicroArray Quality Control (MAQC project evaluated the inter- and intra-platform reproducibility of seven microarray platforms and three quantitative gene expression assays in profiling the expression of two commercially available Reference RNA samples (Nat Biotechnol 24:1115-22, 2006. The tested microarrays were the platforms from Affymetrix, Agilent Technologies, Applied Biosystems, GE Healthcare, Illumina, Eppendorf and the National Cancer Institute, and quantitative gene expression assays included TaqMan® Gene Expression PCR Assay, Standardized (Sta RT-PCR™ and QuantiGene®. The data showed great consistency in gene expression measurements across different microarray platforms, different technologies and test sites. However, SYBR® Green real-time PCR, another common technique utilized by half of all real-time PCR users for gene expression measurement, was not addressed in the MAQC study. In the present study, we compared the performance of SYBR Green PCR with TaqMan PCR, microarrays and other quantitative technologies using the same two Reference RNA samples as the MAQC project. We assessed SYBR Green real-time PCR using commercially available RT2 Profiler™ PCR Arrays from SuperArray, containing primer pairs that have been experimentally validated to ensure gene-specificity and high amplification efficiency. Results The SYBR Green PCR Arrays exhibit good reproducibility among different users, PCR instruments and test sites. In addition, the SYBR Green PCR Arrays have the highest concordance with TaqMan PCR, and a high level of concordance with other quantitative methods and microarrays that were evaluated in this study in terms of fold-change correlation and overlap of lists of differentially expressed genes. Conclusion These data demonstrate that SYBR Green real-time PCR delivers highly comparable results in gene expression measurement with TaqMan PCR and other high-density microarrays.

  20. Temperature-sensitive gold-nanotube array membranes modified with poly (N-isopropylacrylamide)

    Institute of Scientific and Technical Information of China (English)

    YANG XiaoHai; WU YingBen; WANG Qing; WANG KeMin; WANG ShengFeng

    2008-01-01

    A kind of temperature-sensitive nanotube array membrane was developed by modifying gold-nanotube array membranes with poly(N-isopropylacrylamide) (PNIPAm). The permeation ability of the membranes at different temperatures was investigated using sodium fluorescein and quantum dots as probes. The results showed that the pore diameter of nanotube was changed due to the reversible response of PNIPAm-modified membranes to temperature, and then the permeation ability of the membranes was changed. The permeation of fluorescence probes was slow and even almost blocked at 25℃ (below the lower critical solution temperature, LCST), since PNIPAm formed expanded structures and decreased the pore size. While at 40℃ (above the LCST), the permeation was increased, since PNIPAm became compact structures and the pore diameter was increased. Furthermore, the permeation ability of the temperature-sensitive nanotube array membranes could be adjusted reversibly and it is possible to use the membranes in nanofluidic devices, nanogates, etc.

  1. Aortic annulus eccentricity before and after transcatheter aortic valve implantation: Comparison of balloon-expandable and self-expanding prostheses

    Energy Technology Data Exchange (ETDEWEB)

    Schuhbaeck, Annika, E-mail: annika.schuhbaeck@uk-erlangen.de [Department of Cardiology, University of Erlangen, Erlangen (Germany); Weingartner, Christina [Department of Cardiology, University of Gießen, Giessen (Germany); Arnold, Martin; Schmid, Jasmin; Pflederer, Tobias; Marwan, Mohamed [Department of Cardiology, University of Erlangen, Erlangen (Germany); Rixe, Johannes; Nef, Holger [Department of Cardiology, University of Gießen, Giessen (Germany); Schneider, Christian [Department of Radiology, University of Gießen, Giessen (Germany); Lell, Michael; Uder, Michael [Department of Radiology, University of Erlangen, Erlangen (Germany); Ensminger, Stephan [Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Ruhr-University Bochum, Bad Oeynhausen (Germany); Feyrer, Richard; Weyand, Michael [Department of Cardiothoracic Surgery, University of Erlangen, Erlangen (Germany); Achenbach, Stephan [Department of Cardiology, University of Erlangen, Erlangen (Germany)

    2015-07-15

    Highlights: • Post-implant geometry of catheter-based aortic valve prostheses is influenced by aortic valve calcification. • Balloon-expandable prostheses are more circular as compared to self-expanding prostheses. • The impact of post-implant geometry on valve function needs to be investigated. - Abstract: Introduction: The geometry of the aortic annulus and implanted transcatheter aortic valve prosthesis might influence valve function. We investigated the influence of valve type and aortic valve calcification on post-implant geometry of catheter-based aortic valve prostheses. Methods: Eighty consecutive patients with severe aortic valve stenosis (mean age 82 ± 6 years) underwent computed tomography before and after TAVI. Aortic annulus diameters were determined. Influence of prosthesis type and degree of aortic valve calcification on post-implant eccentricity were analysed. Results: Aortic annulus eccentricity was reduced in patients after TAVI (0.21 ± 0.06 vs. 0.08 ± 0.06, p < 0.0001). Post-TAVI eccentricity was significantly lower in 65 patients following implantation of a balloon-expandable prosthesis as compared to 15 patients who received a self-expanding prosthesis (0.06 ± 0.05 vs. 0.15 ± 0.07, p < 0.0001), even though the extent of aortic valve calcification was not different. After TAVI, patients with a higher calcium amount retained a significantly higher eccentricity compared to patients with lower amounts of calcium. Conclusions: Patients undergoing TAVI with a balloon-expandable prosthesis show a more circular shape of the implanted prosthesis as compared to patients with a self-expanding prosthesis. Eccentricity of the deployed prosthesis is affected by the extent of aortic valve calcification.

  2. Aortic annulus eccentricity before and after transcatheter aortic valve implantation: Comparison of balloon-expandable and self-expanding prostheses

    International Nuclear Information System (INIS)

    Highlights: • Post-implant geometry of catheter-based aortic valve prostheses is influenced by aortic valve calcification. • Balloon-expandable prostheses are more circular as compared to self-expanding prostheses. • The impact of post-implant geometry on valve function needs to be investigated. - Abstract: Introduction: The geometry of the aortic annulus and implanted transcatheter aortic valve prosthesis might influence valve function. We investigated the influence of valve type and aortic valve calcification on post-implant geometry of catheter-based aortic valve prostheses. Methods: Eighty consecutive patients with severe aortic valve stenosis (mean age 82 ± 6 years) underwent computed tomography before and after TAVI. Aortic annulus diameters were determined. Influence of prosthesis type and degree of aortic valve calcification on post-implant eccentricity were analysed. Results: Aortic annulus eccentricity was reduced in patients after TAVI (0.21 ± 0.06 vs. 0.08 ± 0.06, p < 0.0001). Post-TAVI eccentricity was significantly lower in 65 patients following implantation of a balloon-expandable prosthesis as compared to 15 patients who received a self-expanding prosthesis (0.06 ± 0.05 vs. 0.15 ± 0.07, p < 0.0001), even though the extent of aortic valve calcification was not different. After TAVI, patients with a higher calcium amount retained a significantly higher eccentricity compared to patients with lower amounts of calcium. Conclusions: Patients undergoing TAVI with a balloon-expandable prosthesis show a more circular shape of the implanted prosthesis as compared to patients with a self-expanding prosthesis. Eccentricity of the deployed prosthesis is affected by the extent of aortic valve calcification

  3. Arrayed primer extension in the "array of arrays" format: a rational approach for microarray-based SNP genotyping

    DEFF Research Database (Denmark)

    Klitø, Niels G F; Tan, Qihua; Nyegaard, Mette;

    2007-01-01

    This study provides a new version of the arrayed primer extension (APEX) protocol adapted to the 'array of arrays' platform using an instrumental setup for microarray processing not previously described. The primary aim of the study is to implement a system for rational cost-efficient genotyping...

  4. Expanding the Role of Connectionism in SLA Theory

    Science.gov (United States)

    Language Learning, 2013

    2013-01-01

    In this article, I explore how connectionism might expand its role in second language acquisition (SLA) theory by showing how some symbolic models of bilingual and second language lexical memory can be reduced to a biologically realistic (i.e., neurally plausible) connectionist model. This integration or hybridization of the two models follows the…

  5. Targeting China's Newly Rich Western Luxury Brands to Expand

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ Western fashion brands have been considering China as a market for cheap raw materials and labor for several centuries.However,in recent months,China's booming economy has attracted the fashion industry.Many high-profit fashion brands said they intend to expand business in China.

  6. Diaspora, Migration, and Globalization: Expanding the Discourse of Adult Education

    Science.gov (United States)

    Alfred, Mary V.

    2015-01-01

    This article explores how notions of diaspora, migration, and globalization intersect to inform identities and social realities of those who leave their homeland and resettle in other nations. It calls for expanding the discourse of adult education to incorporate critical studies of the diaspora to make visible the inequality and imbalance of…

  7. Timor Leste - Expanding Near-Term Agricultural Exports : Report Annexes

    OpenAIRE

    World Bank

    2011-01-01

    The Government of Timor-Leste (GOTL) is committed to the development of the non-oil economy by enabling the diversification of domestic production and trade integration. The objective of the Timor-Leste Diagnostic Trade Integration Study (DTIS) is to agree on priority actions to help overcome constraints to expanding agricultural exports in the near-term. It supports the government's effor...

  8. Timor Leste - Expanding Near-Term Agricultural Exports - Main Report

    OpenAIRE

    World Bank

    2011-01-01

    The Government of Timor-Leste (GOTL) is committed to the development of the non-oil economy by enabling the diversification of domestic production and trade integration. The objective of the Timor-Leste Diagnostic Trade Integration Study (DTIS) is to agree on priority actions to help overcome constraints to expanding agricultural exports in the near-term. It supports the government's effor...

  9. Study of torque matching of revolving vane compressor and expander

    Science.gov (United States)

    Subiantoro, A.; Ooi, K. T.

    2015-08-01

    An investigation was carried out to find the most optimum configuration, particularly the torque matching characteristics, of an integrated Revolving Vane compressor- expander. To carry out the study, a mathematical model of the integrated compressor-expander was developed. An open cycle air refrigeration system was adopted. The controlled parameter was the angle shift between the compressor and the expander. The observed parameters were the peak torque requirement and the bearing load. The results show that when properly matched, the peak torque can be reduced by more than 65% while the bearing loads can be reduced by up to 25%, depending on operating conditions. Unfortunately, the optimum angle shifts for peak torque do not always coincide with those for bearing load. When the pressure and inertial components of the torques are comparable or when the inertial component is dominant, the optimum angle shifts for peak torque and bearing load are around 180° and 330°, respectively. When the pressure component is dominant, the optimum angle shift for peak torque is equal to the angle difference between the pressure peak torques of the compressor and the expander while for bearing load is around 150°.

  10. Afterloading intracavitary irradiation and expanding stent for malignant biliary obstruction

    International Nuclear Information System (INIS)

    A double lumen catheter was developed as an apllicator for the remote afterloading (RALS) of 60Co source for the intracavitary irradiation of an obstructed common bile duct caused by carcinoma of the gallbladder. This was followed by the placement of nylon-covered expandable metallic stents to maintain patency. This combination effectively provided palliation. (author)

  11. Food for Thought: Expanding School Breakfast to NJ Students

    Science.gov (United States)

    Allen-Kyle, Portia; Parello, Nancy

    2011-01-01

    This brief marks the start of "Advocates for Children of New Jersey's Food for Thought School Breakfast Campaign", which seeks to expand innovative approaches to serving school breakfast and significantly increase students' participation rates. This report provides a closer look at the data, including identifying districts that have high…

  12. Cultural Immersion as a Learning Method for Expanding Intercultural Competencies

    Science.gov (United States)

    Canfield, Brian S.; Low, Lori; Hovestadt, Alan

    2009-01-01

    This article presents an overview of the development and utilization of a cultural immersion experience assignment in courses that focus on expanding the knowledge and skill set of counselors and other counseling professionals for working with culturally diverse client populations. The utility of this method and specific suggestions for its use in…

  13. Role of clay microstructure in expandable buffer clay

    Czech Academy of Sciences Publication Activity Database

    Pusch, R.; Přikryl, R.; Weishauptová, Zuzana; Xiaodong, L.; Knutsson, S.

    2012-01-01

    Roč. 1, č. 6 (2012), s. 267-292. ISSN 2232-1179 R&D Projects: GA ČR GA205/08/0676 Institutional research plan: CEZ:AV0Z30460519 Keywords : cementation * expandable clay * hydraulic conductivity Subject RIV: DL - Nuclear Waste, Radioactive Pollution ; Quality http://pure.ltu.se/portal/files/39920921/332.pdf

  14. Lattice expansion of carbon-stabilized expanded austenite

    DEFF Research Database (Denmark)

    Hummelshøj, Thomas Strabo; Christiansen, Thomas; Somers, Marcel A. J.

    2010-01-01

    The lattice parameter of expanded austenite was determined as a function of the content of interstitially dissolved carbon in homogeneous, carburized thin stainless steel foils. For the first time this expansion of the face-centered cubic lattice is determined on unstrained austenite. It is found...

  15. Expanded Specification for Reducing Bioburden Using Dry Heat Microbial Reduction

    Science.gov (United States)

    Conley, Catharine; Kminek, Gerhard

    2012-07-01

    The presentation will detail expanded Planetary Protection specifications for the approved Dry Heat Microbial Reduction (DHMR) process for spacecraft and will summarize the comprehensive research effort underlying the specifications. The research was conducted at NASA/JPL and ESA and spanned a period of several years.

  16. The Instructional Values of Humanistic Educators: An Expanded, Empirical Analysis.

    Science.gov (United States)

    Shapiro, Stewart B.

    1987-01-01

    Expanded a previous factorial study of the writings of 40 humanistic educators by including 89 educators. Revealed two new factors--self-determined evaluation and a spiritual-transpersonal factor--as important principles of humanistic education. Confirmed the original factors, a general humanistic instructional paradigm, democratically induced…

  17. Finite creation of particles in an expanding universe

    International Nuclear Information System (INIS)

    Herein it is shown that a formulation of the free-scalar-field theory in an expanding universe, based on the quantum equivalence principle (QEP), leads to a finite creation of particles at the expense of the gravitational field. In this formulation, the mean value of the T00 component of the energy-momentum tensor is divergent. (author)

  18. Finite creation of particles in an expanding universe

    Energy Technology Data Exchange (ETDEWEB)

    Ceccatto, H.; Foussats, A.; Giacomini, H.; Zandron, O. (Universidad Nacional de Rosario (Argentina). Dept. de Fisica)

    1981-09-11

    We show herein that a formulation of the free-scalar-field theory in an expanding universe, based on the quantum equivalence principle (QEP), leads to a finite creation of particles at the expense of the gravitational field. In this formulation, the mean value of the T/sup 00/ component of the energy-momentum tensor is divergent.

  19. Finite creation of particles in an expanding universe

    Energy Technology Data Exchange (ETDEWEB)

    Ceccatto, H.; Foussats, A.; Giacomini, H.; Zandron, O. (Rosario Univ. Nacional (Argentina). Dept. de Fisica)

    1981-09-11

    Herein it is shown that a formulation of the free-scalar-field theory in an expanding universe, based on the quantum equivalence principle (QEP), leads to a finite creation of particles at the expense of the gravitational field. In this formulation, the mean value of the T/sup 00/ component of the energy-momentum tensor is divergent.

  20. Expanding Interventions for Children with Autism: Parents as Trainers

    Science.gov (United States)

    Symon, Jennifer B.

    2005-01-01

    The number of individuals diagnosed with autism has risen at an alarming rate. Expanding services should be a primary consideration of programs for children and their families. This article presents outcome data from a week-long parent education program for families of children with autism to suggest that parents can learn not only how to…

  1. Nearly MDS expander codes with reduced alphabet size

    OpenAIRE

    Armand, Marc A.; Zhang, Jianwen

    2007-01-01

    Recently, Roth and Skachek proposed two methods for constructing nearly maximum-distance separable (MDS) expander codes. We show that through the simple modification of using mixed-alphabet codes derived from MDS codes as constituent codes in their code designs, one can obtain nearly MDS codes of significantly smaller alphabet size, albeit at the expense of a (very slight) reduction in code rate.

  2. Fire Resistance of Concrete Constructions with Expanded Clay Aggregate

    DEFF Research Database (Denmark)

    Hertz, Kristian Dahl

    The paper describes briefly a series of full-scale tests made as documentation for extending the field of application of the reduced cross section method from the structural codes to constructions based on expanded clay aggregate. As a special result the tests verify that slabs with a short...

  3. The Expanded Food and Nutrition Education Program (EFNEP)

    Science.gov (United States)

    National Institute of Food and Agriculture, 2010

    2010-01-01

    Obesity, poor health, and limited physical activity are major health concerns. The Expanded Food and Nutrition Education Program (EFNEP) improves the health and well-being of limited resource families and youth. Additionally, EFNEP leads to public savings. Research shows that better health is associated with reduced health care costs, less…

  4. 2010 Impacts: The Expanded Food and Nutrition Education Program (EFNEP)

    Science.gov (United States)

    National Institute of Food and Agriculture, 2011

    2011-01-01

    Since 1969, the Expanded Food and Nutrition Education Program (EFNEP) has improved the diets and food-related behaviors of program participants. Each year EFNEP enrolls more than half a million new program participants. In 2010, EFNEP reached 137,814 adults and 463,530 youth directly and nearly 400,000 family members indirectly. This paper…

  5. Contracting/expanding self-sealing cryogenic tube seals

    Science.gov (United States)

    Jia, Lin X. (Inventor)

    1997-01-01

    Contracting/expanding self-sealing cryogenic tube seals are disclosed which use the different properties of thermal contraction and expansion of selected dissimilar materials in accord with certain design criteria to yield self-tightening seals via sloped-surface sealing. The seals of the subject invention are reusable, simple to assemble, and adaptable to a wide variety of cryogenic applications.

  6. Crowd Around: Expanding Your Donor Pool with Crowdfunding

    Science.gov (United States)

    Jarrell, Andrea

    2013-01-01

    At most institutions, annual fund-giving is down. Crowdfunding sites allow people with a great idea or worthy cause to bypass traditional funding methods and take their case directly to web-savvy investors and donors. This article describes how higher education institutions are expanding their donor pool through such crowdfunding sites as USEED,…

  7. Validation of the Chinese Expanded Euthanasia Attitude Scale

    Science.gov (United States)

    Chong, Alice Ming-Lin; Fok, Shiu-Yeu

    2013-01-01

    This article reports the validation of the Chinese version of an expanded 31-item Euthanasia Attitude Scale. A 4-stage validation process included a pilot survey of 119 college students and a randomized household survey with 618 adults in Hong Kong. Confirmatory factor analysis confirmed a 4-factor structure of the scale, which can therefore be…

  8. Particle creations by expanding universe and suppression of supercooling

    International Nuclear Information System (INIS)

    We study particle creations by the background metric of the exponentially expanding Universe, which is accompanied with the first order phase transition. The number density of the created particles is shown to be >=(1011 GeV)3 in the natural unit. Cosmological implications are discussed. (author)

  9. Dynamical 3-Space: Black Holes in an Expanding Universe

    Directory of Open Access Journals (Sweden)

    Rothall D. P.

    2013-10-01

    Full Text Available Black holes are usually studied without including effects of the expanding universe. However in some recent studies black holes have been embedded in an expanding universe, in order to determine the interplay, if any, of these two dynamical processes. Dynamical 3-space theory contains time independent solutions for black holes, which are spatial in-flows, and separately the time dependent Hubble expansion. This theory has explained numerous puzzles in observational astrophysics and contains 3 constants; G, - which from experimental data turns out to be the fine structure constant, and - which is a small but nonzero distance, possibly a Planck-type length. The Hubble expansion in the dynamical 3-space theory cannot be “switched o”, forcing the study, first, of isolated black holes coexisting with the expanding universe. It is shown that a time dependent black hole and expanding universe solution exists. The nature and implications of these solutions are discussed as they evolve over time. A dynamical network of black holes and induced linking cosmic filaments forming bubble structures is discussed, as a consequence of dynamical 3-space undergoing a dynamical breakdown of homogeneity and isotropy, even in the absence of baryonic matter.

  10. Expanding the Oral Hygiene Curriculum in a Nursing Program.

    Science.gov (United States)

    Briggs, Susan; Griego, Elizabeth

    A program was implemented to expand the curriculum materials within the Licensed Practical Nursing (LPN) Program at Clark County Community College (CCCC) which relate to oral hygiene care for the hospital patient. The instructional materials included a video tape and a written instructional packet which were researched, prepared, and presented by…

  11. Expanding the Vision of Self: Why the Arts Matter

    Science.gov (United States)

    Nathan, Linda F.

    2013-01-01

    In this reflective essay, Linda F. Nathan, the founding headmaster of the Boston Arts Academy and currently the executive director of Center for Arts in Education at Boston Arts Academy, shares a story about how one student, Ronald, expands his vision of self through his engagement with the arts. In presenting this reflection on Ronald's…

  12. Expanding Possibilities through Metaphor: Breaking Biases to Improve Crisis Management

    Science.gov (United States)

    Cirka, Carol C.; Corrigall, Elizabeth A.

    2010-01-01

    In this article, we demonstrate that an exercise using metaphors to overcome cognitive biases helped students to proactively imagine and prepare for an expanded set of potential crises. The exercise complements traditional textbook approaches to crisis management and incorporates creativity skill building in a realistic context. Learning outcomes…

  13. Children's Books in Review: Expand Kids' Knowledge with Nonfiction Books.

    Science.gov (United States)

    Winfield, Evelyn T.

    1991-01-01

    Examines several current nonfiction books that can expand a child's knowledge of a wide variety of subjects, noting that the breadth of a child's knowledge base affects his or her reading development. Subjects discussed include dinosaurs, animal preservation, insects, ecology, history, and drugs and alcohol. (SM)

  14. DEMONSTRATION OF PACKAGING MATERIALS ALTERNATIVES TO EXPANDED POLYSTYRENE

    Science.gov (United States)

    This report represents the second demonstration of cleaner technologies to support the goals of the 33/50 Program under the EPA Cooperative Agreement No. CR-821848. The report presents assessment results of alternative packaging materials which could potentially replace expanded...

  15. 78 FR 37431 - Expanding America's Leadership in Wireless Innovation

    Science.gov (United States)

    2013-06-20

    .... (Presidential Sig.) THE WHITE HOUSE, Washington, June 14, 2013. [FR Doc. 2013-14971 Filed 6-19-13; 11:15 am... Documents#0;#0; ] Memorandum of June 14, 2013 Expanding America's Leadership in Wireless Innovation... innovation, private investment, and smart policy has positioned the United States as the global leader...

  16. Expanding Access to Adult Literacy with Online Distance Education.

    Science.gov (United States)

    Askov, Eunice N.; Johnston, Jerome; Petty, Leslie I.; Young, Shannon J.

    This monograph examines benefits, challenges, and methods of expanding access to adult literacy with online distance education (ODE). The following are among the topics discussed: (1) reasons for considering ODE (new technologies and delivery systems in education; ODE in higher education, business training, and adult basic education; state-level…

  17. Expediting the corrective action process: The expanded assessment

    International Nuclear Information System (INIS)

    The expedient assessment of environmental contamination by underground petroleum is necessary to facilitate more efficient remediation. The expanded assessment format is designed to allow greater flexibility for the contractor, decrease the time necessary to complete site assessment, and achieve overall cost savings by eliminating multiple reports and associated administrative costs

  18. Large Format Uncooled Focal Plane Array Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Uncooled focal plane arrays have improved dramatically and array sizes of 320x240 elements in a 50-?m pitch are commercially available at affordable cost. Black...

  19. Low Cost Phased Array Antenna System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — JEM Engineering proved the technical feasibility of the FlexScan array?a very low-cost, highly-efficient, wideband phased array antenna?in Phase I, and stands ready...

  20. Expanded retroauricular skin and fascial flap in congenital microtia reconstruction.

    Science.gov (United States)

    Zhang, Qingguo; Quan, Yuzhu; Su, Yuanda; Shi, Lei; Xie, Yangchun; Liu, Xinhai

    2010-04-01

    The aim of this article is to report the application of expanding retroauricular skin fascia flap, and autogenous costal cartilage for congenital microtia reconstruction. Microtia reconstruction was generally completed in 3 surgical stages. In the first surgical stage, a 50 or 80 mL kidney-shaped tissue expander was inserted subcutaneously in the retroauricular mastoid region. Inflation of saline volume increased up to 60 to 80 mL, and skin flap was expanded for 2 to 3 months postoperatively. In the second surgical stage, removal of tissue expander, formation of retroauricular skin flap, elevation of retroauricular fascia flap, and pedicles of both flaps in remnant ear side were performed. Costal cartilage was harvested from ipsilateral side chest to the ear for reconstruction. The 3D ear framework was sculpted with stabilization of structure, contour and erection. Simultaneously, intermediate full thickness skin graft of 4 x 8 cm was obtained from previous incision site from where costal cartilage was harvested. Cartilage ear framework was anchored between skin flap and fascia flap, and fixed it symmetrically to the opposite normal ear, inferior portion of the ear framework was wrapped by remnant ear lobule, expanded skin flap covered the anterior portion of the framework, fascial flap was draped to the posterior side of framework and helical rim, then fascial flap was surfaced by intermediate full thickness skin graft. Suction drain was inserted and coated between skin flap and framework, drain was removed fifth postoperative day. Tragus construction and conchal excavation with skin graft was performed in the third stage of microtia reconstruction. Between October 2000 and October 2007, 426 cases were diagnosed as unilateral microtia patients and 22 cases were bilateral microtia patients. Therefore, 448 microtia ears were treated with tissue expander and autogenous costal cartilage. In 262 cases, structure of the helix, tragus, conchal excavation

  1. EXPANDER – an integrative program suite for microarray data analysis

    Directory of Open Access Journals (Sweden)

    Shiloh Yosef

    2005-09-01

    Full Text Available Abstract Background Gene expression microarrays are a prominent experimental tool in functional genomics which has opened the opportunity for gaining global, systems-level understanding of transcriptional networks. Experiments that apply this technology typically generate overwhelming volumes of data, unprecedented in biological research. Therefore the task of mining meaningful biological knowledge out of the raw data is a major challenge in bioinformatics. Of special need are integrative packages that provide biologist users with advanced but yet easy to use, set of algorithms, together covering the whole range of steps in microarray data analysis. Results Here we present the EXPANDER 2.0 (EXPression ANalyzer and DisplayER software package. EXPANDER 2.0 is an integrative package for the analysis of gene expression data, designed as a 'one-stop shop' tool that implements various data analysis algorithms ranging from the initial steps of normalization and filtering, through clustering and biclustering, to high-level functional enrichment analysis that points to biological processes that are active in the examined conditions, and to promoter cis-regulatory elements analysis that elucidates transcription factors that control the observed transcriptional response. EXPANDER is available with pre-compiled functional Gene Ontology (GO and promoter sequence-derived data files for yeast, worm, fly, rat, mouse and human, supporting high-level analysis applied to data obtained from these six organisms. Conclusion EXPANDER integrated capabilities and its built-in support of multiple organisms make it a very powerful tool for analysis of microarray data. The package is freely available for academic users at http://www.cs.tau.ac.il/~rshamir/expander

  2. Exergetic Optimization of a Solar Photovoltaic Array

    OpenAIRE

    Amin Behzadmehr; Hossein Ajam; Said Farahat; Faramarz Sarhaddi

    2009-01-01

    An exergetic optimization is developed to determine the optimal performance and design parameters of a solar photovoltaic (PV) array. A detailed energy and exergy analysis is carried out to evaluate the electrical performance, exergy destruction components, and exergy efficiency of a typical PV array. The exergy efficiency of a PV array obtained in this paper is a function of climatic, operating, and design parameters such as ambient temperature, solar radiation intensity, PV array temperatur...

  3. Leakage analysis of crossbar memristor arrays

    KAUST Repository

    Zidan, Mohammed A.

    2014-07-01

    Crossbar memristor arrays provide a promising high density alternative for the current memory and storage technologies. These arrays suffer from parasitic current components that significantly increase the power consumption, and could ruin the readout operation. In this work we study the trade-off between the crossbar array density and the power consumption required for its readout. Our analysis is based on simulating full memristor arrays on a SPICE platform.

  4. CAPweb: a bioinformatics CGH array Analysis Platform

    OpenAIRE

    Liva, Stéphane; Hupé, Philippe; Neuvial, Pierre; Brito, Isabel; Viara, Eric; La Rosa, Philippe; Barillot, Emmanuel

    2006-01-01

    Assessing variations in DNA copy number is crucial for understanding constitutional or somatic diseases, particularly cancers. The recently developed array-CGH (comparative genomic hybridization) technology allows this to be investigated at the genomic level. We report the availability of a web tool for analysing array-CGH data. CAPweb (CGH array Analysis Platform on the Web) is intended as a user-friendly tool enabling biologists to completely analyse CGH arrays from the raw data to the visu...

  5. Far-infrared imaging antenna arrays

    OpenAIRE

    Neikirk, Dean P.; Rutledge, David B.; Muha, Michael S.; Park, Hyeon; Yu, Chang-Xuan

    1982-01-01

    A far-infrared imaging antenna array has been demonstrated for the first time. The array is a line of evaporated silver bow-tie antennas on a fused-quartz substrate with bismuth-microbolometer detectors. The measured optical transfer function shows that the system is diffraction limited. This imaging array should find direct application in fusion plasma diagnostics. If the microbolometers can be replaced by more sensitive diode detectors, the array should also find application in radiometry a...

  6. Microneedle array electrode for human EEG recording

    NARCIS (Netherlands)

    Luttge, Regina; Bystrova, S.N.; Putten, van M.J.A.M; Vander Sloten, Jos; Verdonck, Pascal; Nyssen, Marc; Haueisen, Jens

    2009-01-01

    Microneedle array electrodes for EEG significantly reduce the mounting time, particularly by circumvention of the need for skin preparation by scrubbing. We designed a new replication process for numerous types of microneedle arrays. Here, polymer microneedle array electrodes with 64 microneedles, i

  7. Laser diode array and transmission optics

    Science.gov (United States)

    Kwon, Jin H.

    1989-01-01

    Information on laser diode array and transmission optics is given in viewgraph form. Information is given on coherent combining of laser diode arrays, amplification through a laser diode array, the far field pattern of a laser diode transmitter, and beam diameter at receiver vs. transmission distance.

  8. Ferroelectric transistor memory arrays on flexible foils

    NARCIS (Netherlands)

    Breemen, A. van; Kam, B.; Cobb, B.; Rodriguez, F.G.; Heck, G. van; Myny, K.; Marrani, A.; Vinciguerra, V.; Gelinck, G.H.

    2013-01-01

    In this paper, we successfully fabricated and operated passive matrix P(VDF-TrFE) transistor arrays, i.e. memory arrays in which no pass-transistors or other additional electronic components are used. Because of the smaller cell, a higher integration density is possible. We demonstrate arrays up to

  9. Beyond Climate and Weather Science: Expanding the Forecasting Family to Serve Societal Needs

    Science.gov (United States)

    Barron, E. J.

    2009-05-01

    The ability to "anticipate" the future is what makes information from the Earth sciences valuable to society - whether it is the prediction of severe weather or the future availability of water resources in response to climate change. An improved ability to anticipate or forecast has the potential to serve society by simultaneously improving our ability to (1) promote economic vitality, (2) enable environmental stewardship, (3) protect life and property, as well as (4) improve our fundamental knowledge of the earth system. The potential is enormous, yet many appear ready to move quickly toward specific mitigation and adaptation strategies assuming that the science is settled. Five important weakness must be addressed first: (1) the formation of a true "climate services" function and capability, (2) the deliberate investment in expanding the family of forecasting elements to incorporate a broader array of environmental factors and impacts, (3) the investment in the sciences that connect climate to society, (4) a deliberate focus on the problems associated with scale, in particular the difference between the scale of predictive models and the scale associated with societal decisions, and (5) the evolution from climate services and model predictions to the equivalent of "environmental intelligence centers." The objective is to bring the discipline of forecasting to a broader array of environmental challenges. Assessments of the potential impacts of global climate change on societal sectors such as water, human health, and agriculture provide good examples of this challenge. We have the potential to move from a largely reactive mode in addressing adverse health outcomes, for example, to one in which the ties between climate, land cover, infectious disease vectors, and human health are used to forecast and predict adverse human health conditions. The potential exists for a revolution in forecasting, that entrains a much broader set of societal needs and solutions. The

  10. Successive normalization of rectangular arrays

    CERN Document Server

    Olshen, Richard A; 10.1214/09-AOS743

    2010-01-01

    Standard statistical techniques often require transforming data to have mean 0 and standard deviation 1. Typically, this process of "standardization" or "normalization" is applied across subjects when each subject produces a single number. High throughput genomic and financial data often come as rectangular arrays where each coordinate in one direction concerns subjects who might have different status (case or control, say), and each coordinate in the other designates "outcome" for a specific feature, for example, "gene," "polymorphic site" or some aspect of financial profile. It may happen, when analyzing data that arrive as a rectangular array, that one requires BOTH the subjects and the features to be "on the same footing." Thus there may be a need to standardize across rows and columns of the rectangular matrix. There arises the question as to how to achieve this double normalization. We propose and investigate the convergence of what seems to us a natural approach to successive normalization which we lea...

  11. Antenna Arrays and Automotive Applications

    CERN Document Server

    Rabinovich, Victor

    2013-01-01

    This book throws a lifeline to designers wading through mounds of antenna array patents looking for the most suitable systems for their projects. Drastically reducing the research time required to locate solutions to the latest challenges in automotive communications, it sorts and systematizes material on cutting-edge antenna arrays that feature multi-element communication systems with enormous potential for the automotive industry. These new systems promise to make driving safer and more efficient, opening up myriad applications, including vehicle-to-vehicle traffic that prevents collisions, automatic toll collection, vehicle location and fine-tuning for cruise control systems. This book’s exhaustive coverage begins with currently deployed systems, frequency ranges and key parameters. It proceeds to examine system geometry, analog and digital beam steering technology (including "smart" beams formed in noisy environments), maximizing signal-to-noise ratios, miniaturization, and base station technology that ...

  12. Invasive tightly coupled processor arrays

    CERN Document Server

    LARI, VAHID

    2016-01-01

    This book introduces new massively parallel computer (MPSoC) architectures called invasive tightly coupled processor arrays. It proposes strategies, architecture designs, and programming interfaces for invasive TCPAs that allow invading and subsequently executing loop programs with strict requirements or guarantees of non-functional execution qualities such as performance, power consumption, and reliability. For the first time, such a configurable processor array architecture consisting of locally interconnected VLIW processing elements can be claimed by programs, either in full or in part, using the principle of invasive computing. Invasive TCPAs provide unprecedented energy efficiency for the parallel execution of nested loop programs by avoiding any global memory access such as GPUs and may even support loops with complex dependencies such as loop-carried dependencies that are not amenable to parallel execution on GPUs. For this purpose, the book proposes different invasion strategies for claiming a desire...

  13. Recent Results from Telescope Array

    CERN Document Server

    Fukushima, M

    2015-01-01

    The Telescope Array (TA) is an experiment to observe Ultra-High Energy Cosmic Rays (UHECRs). TA's recent results, the energy spectrum and anisotropy based on the 6-year surface array data, and the primary composition obtained from the shower maximum Xmax are reported. The spectrum demonstrates a clear dip and cutoff. The shape of the spectrum is well described by the energy loss of extra-galactic protons interacting with the cosmic microwave background (CMB). Above the cutoff, a medium-scale (20 degrees radius) flux enhancement was observed near the Ursa-Major. A chance probability of creating this hotspot from the isotropic flux is 4.0 sigma. The measured Xmax is consistent with the primary being proton or light nuclei for energies 10^18.2 eV - 10^19.2 eV.

  14. Multicultural Counseling beyond the Relationship: Expanding the Repertoire with Techniques

    Science.gov (United States)

    Hanna, Fred J.; Cardona, Betty

    2013-01-01

    Multicultural counseling approaches variously focus on the counseling relationship. Relatively few discuss clinical techniques and strategies to any significant extent. This article explores enhancing multicultural counseling by offering an array of techniques and strategies based on addressing oppression and increasing psychological freedom.…

  15. Automated Camera Array Fine Calibration

    Science.gov (United States)

    Clouse, Daniel; Padgett, Curtis; Ansar, Adnan; Cheng, Yang

    2008-01-01

    Using aerial imagery, the JPL FineCalibration (JPL FineCal) software automatically tunes a set of existing CAHVOR camera models for an array of cameras. The software finds matching features in the overlap region between images from adjacent cameras, and uses these features to refine the camera models. It is not necessary to take special imagery of a known target and no surveying is required. JPL FineCal was developed for use with an aerial, persistent surveillance platform.

  16. Optical MEMS-based arrays

    Science.gov (United States)

    Ruffin, Paul B.

    2003-07-01

    Industrial Micro Electro Mechanical Systems (MEMS) developers are rapidly bringing to demonstration inertial radio frequency, and optical MEMS devices and components. The Army has a requirement for compact, highly reliable, and inexpensive laser beam steering components for missile seekers and unmanned aerial vehicles remote sensing components to provide a fast scanning capability for pointing, acquisition, tracking, and data communication. The coupling of this requirement with recent developments in the micro-optics area, has led scientists and engineers at the Army Aviation and Missile Command (AMCOM) to consider optical MEMS-based phased arrays, which have potential applications in the commercial industry as well as in the military, as a replacement for gimbals. Laser beam steering in commercial applications such as free space communicataion, scanning display, bar-code reading, and gimbaled seekers; require relatively large monolithic micro-mirrors to accomplish the required optical resolution. The Army will benefit from phased arrays composed of relatively small micro-mirrors that can be actuated through large deflection angles with substantially reduced volume times. The AMCOM Aviation and Missile Research, Development, and Engineering Center (AMRDEC) has initiated a research project to develop MEMS-based phased arrays for use in a small volume, inexpensive Laser Detection and Ranging (LADAR) seeker that is particularly attractive because of its ability to provide large field-of-regard and autonomous target acquisition for reconnaissance mission applications. The primary objective of the collaborative project with the Defence Advanced Research Projects Agency (DARPA) is to develop a rugged, MEMS-based phased arrays for incorporation into the 2-D scanner of a LADAR seeker. Design challenges and approach to achieving performance requirements will be discussed.

  17. Including the pulsar-term in continuous gravitational-wave searches using pulsar timing arrays: a blessing and a curse

    CERN Document Server

    Taylor, Stephen; Gair, Jonathan

    2014-01-01

    We describe several new techniques which accelerate Bayesian searches for continuous gravitational-wave emission from supermassive black-hole binaries using pulsar timing arrays. These techniques mitigate the problematic increase of search-dimensionality with the size of the pulsar array which arises from having to include an extra parameter per pulsar as the array is expanded. This extra parameter corresponds to searching over the phase of the gravitational-wave as it propagates past each pulsar so that we can coherently include the pulsar-term in our search strategies. Our techniques make the analysis tractable with powerful evidence-evaluation packages like MultiNest. We find good agreement of our techniques with the parameter-estimation and Bayes factor evaluation performed with full signal templates, and conclude that these techniques make excellent first-cut tools for detection and characterisation of continuous gravitational-wave signals with pulsar timing arrays. Crucially, at low to moderate signal-t...

  18. Molecular Occupancy of Nanodot Arrays.

    Science.gov (United States)

    Cai, Haogang; Wolfenson, Haguy; Depoil, David; Dustin, Michael L; Sheetz, Michael P; Wind, Shalom J

    2016-04-26

    Single-molecule nanodot arrays, in which a biomolecule of choice (protein, nucleic acid, etc.) is bound to a metallic nanoparticle on a solid substrate, are becoming an increasingly important tool in the study of biomolecular and cellular interactions. We have developed an on-chip measurement protocol to monitor and control the molecular occupancy of nanodots. Arrays of widely spaced nanodots and nanodot clusters were fabricated on glass surfaces by nanolithography and functionalized with fluorescently labeled proteins. The molecular occupancy was determined by monitoring individual fluorophore bleaching events, while accounting for fluorescence quenching effects. We found that the occupancy can be interpreted as a packing problem, and depends on nanodot size and binding ligand concentration, where the latter is easily adjusted to compensate the flexibility of dimension control in nanofabrication. The results are scalable with nanodot cluster size, extending to large area close packed arrays. As an example, the nanoarray platform was used to probe the geometric requirement of T-cell activation at the single-molecule level. PMID:26966946

  19. Measured Aperture-Array Noise Temperature of the Mark II Phased Array Feed for ASKAP

    CERN Document Server

    Chippendale, A P; Beresford, R J; Hampson, G A; Shaw, R D; Hayman, D B; Macleod, A; Forsyth, A R; Hay, S G; Leach, M; Cantrall, C; Brothers, M L; Hotan, A W

    2015-01-01

    We have measured the aperture-array noise temperature of the first Mk. II phased array feed that CSIRO has built for the Australian Square Kilometre Array Pathfinder telescope. As an aperture array, the Mk. II phased array feed achieves a beam equivalent noise temperature less than 40 K from 0.78 GHz to 1.7 GHz and less than 50 K from 0.7 GHz to 1.8 GHz for a boresight beam directed at the zenith. We believe these are the lowest reported noise temperatures over these frequency ranges for ambient-temperature phased arrays. The measured noise temperature includes receiver electronics noise, ohmic losses in the array, and stray radiation from sidelobes illuminating the sky and ground away from the desired field of view. This phased array feed was designed for the Australian Square Kilometre Array Pathfinder to demonstrate fast astronomical surveys with a wide field of view for the Square Kilometre Array.

  20. Acoustic array systems theory, implementation, and application

    CERN Document Server

    Bai, Mingsian R; Benesty, Jacob

    2013-01-01

    Presents a unified framework of far-field and near-field array techniques for noise source identification and sound field visualization, from theory to application. Acoustic Array Systems: Theory, Implementation, and Application provides an overview of microphone array technology with applications in noise source identification and sound field visualization. In the comprehensive treatment of microphone arrays, the topics covered include an introduction to the theory, far-field and near-field array signal processing algorithms, practical implementations, and common applic

  1. Iso-array rewriting P systems with context-free iso-array rules

    OpenAIRE

    Bhuvaneswari, K; Kalyani, T.; Thomas, D G; Nagar, A. K.; Thamburaj, R.

    2014-01-01

    A new computing model called P system is a highly distributed and parallel theoretical model, which is proposed in the area of membrane computing. Ceterchi et al. initially proposed array rewriting P systems by extending the notion of string rewriting P systems to arrays (2003). A theoretical model for picture generation using context-free iso-array grammar rules and puzzle iso-array grammar rules are introduced by Kalyani et al. (2004, 2006). Also iso-array rewriting P...

  2. Design of circular differential microphone arrays

    CERN Document Server

    Benesty, Jacob; Cohen, Israel

    2015-01-01

    Recently, we proposed a completely novel and efficient way to design differential beamforming algorithms for linear microphone arrays. Thanks to this very flexible approach, any order of differential arrays can be designed. Moreover, they can be made robust against white noise amplification, which is the main inconvenience in these types of arrays. The other well-known problem with linear arrays is that electronic steering is not really feasible.  In this book, we extend all these fundamental ideas to circular microphone arrays and show that we can design small and compact differential arrays of any order that can be electronically steered in many different directions and offer a good degree of control of the white noise amplification problem, high directional gain, and frequency-independent response. We also present a number of practical examples, demonstrating that differential beamforming with circular microphone arrays is likely one of the best candidates for applications involving speech enhancement (i....

  3. Integrating Scientific Array Processing into Standard SQL

    Science.gov (United States)

    Misev, Dimitar; Bachhuber, Johannes; Baumann, Peter

    2014-05-01

    We live in a time that is dominated by data. Data storage is cheap and more applications than ever accrue vast amounts of data. Storing the emerging multidimensional data sets efficiently, however, and allowing them to be queried by their inherent structure, is a challenge many databases have to face today. Despite the fact that multidimensional array data is almost always linked to additional, non-array information, array databases have mostly developed separately from relational systems, resulting in a disparity between the two database categories. The current SQL standard and SQL DBMS supports arrays - and in an extension also multidimensional arrays - but does so in a very rudimentary and inefficient way. This poster demonstrates the practicality of an SQL extension for array processing, implemented in a proof-of-concept multi-faceted system that manages a federation of array and relational database systems, providing transparent, efficient and scalable access to the heterogeneous data in them.

  4. Self-Attracting Poisson Clouds in an Expanding Universe

    Science.gov (United States)

    Bertoin, Jean

    We consider the following elementary model for clustering by ballistic aggregation in an expanding universe. At the initial time, there is a doubly infinite sequence of particles lying in a one-dimensional universe that is expanding at constant rate. We suppose that each particle p attracts points at a certain rate a(p)/2 depending only on p, and when two particles, say p and q, collide by the effect of attraction, they merge as a single particle p*q. The main purpose of this work is to point at the following remarkable property of Poisson clouds in these dynamics. Under certain technical conditions, if at the initial time the system is distributed according to a spatially stationary Poisson cloud with intensity μ0, then at any time t > 0, the system will again have a Poissonian distribution, now with intensity μt, where the family solves a generalization of Smoluchowski's coagulation equation.

  5. Expanded microchannel heat exchanger: design, fabrication and preliminary experimental test

    CERN Document Server

    Denkenberger, David C; Pearce, Joshua M; Zhai, John; 10.1177/0957650912442781

    2012-01-01

    This paper first reviews non-traditional heat exchanger geometry, laser welding, practical issues with microchannel heat exchangers, and high effectiveness heat exchangers. Existing microchannel heat exchangers have low material costs, but high manufacturing costs. This paper presents a new expanded microchannel heat exchanger design and accompanying continuous manufacturing technique for potential low-cost production. Polymer heat exchangers have the potential for high effectiveness. The paper discusses one possible joining method - a new type of laser welding named "forward conduction welding," used to fabricate the prototype. The expanded heat exchanger has the potential to have counter-flow, cross-flow, or parallel-flow configurations, be used for all types of fluids, and be made of polymers, metals, or polymer-ceramic precursors. The cost and ineffectiveness reduction may be an order of magnitude or more, saving a large fraction of primary energy. The measured effectiveness of the prototype with 28 micro...

  6. Time-expanded speech and speech recognition in older adults.

    Science.gov (United States)

    Vaughan, Nancy E; Furukawa, Izumi; Balasingam, Nirmala; Mortz, Margaret; Fausti, Stephen A

    2002-01-01

    Speech understanding deficits are common in older adults. In addition to hearing sensitivity, changes in certain cognitive functions may affect speech recognition. One such change that may impact the ability to follow a rapidly changing speech signal is processing speed. When speakers slow the rate of their speech naturally in order to speak clearly, speech recognition is improved. The acoustic characteristics of naturally slowed speech are of interest in developing time-expansion algorithms to improve speech recognition for older listeners. In this study, we tested younger normally hearing, older normally hearing, and older hearing-impaired listeners on time-expanded speech using increased duration and increased intensity of unvoiced consonants. Although all groups performed best on unprocessed speech, performance with processed speech was better with the consonant gain feature without time expansion in the noise condition and better at the slowest time-expanded rate in the quiet condition. The effects of signal processing on speech recognition are discussed. PMID:17642020

  7. Analysis of a Low-Angle Annular Expander Nozzle

    Directory of Open Access Journals (Sweden)

    Kyll Schomberg

    2015-01-01

    Full Text Available An experimental and numerical analysis of a low-angle annular expander nozzle is presented to observe the variance in shock structure within the flow field. A RANS-based axisymmetric numerical model was used to evaluate flow characteristics and the model validated using experimental pressure readings and schlieren images. Results were compared with an equivalent converging-diverging nozzle to determine the capability of the wake region in varying the effective area of a low-angle design. Comparison of schlieren images confirmed that shock closure occurred in the expander nozzle, prohibiting the wake region from affecting the area ratio. The findings show that a low angle of deflection is inherently unable to influence the effective area of an annular supersonic nozzle design.

  8. Expanding cylinder experiments in Cu-2wt%Be

    Science.gov (United States)

    Stirk, Stewart; Winter, Ron

    2011-06-01

    Expanding cylinder techniques are useful methods of investigating dynamic fracture properties since uniform radial strains are achieved at high strain-rates. A gas-gun technique to achieve uniform radial expansion of a cylinder is explored in which the motion of the cylinder is driven by impact of a plastic projectile upon silastomer rubber that partially fills the specimen cylinder. Cylinders of age-hardened copper-beryllium alloy Cu-2wt%Be (TF00 treatment) have been expanded to failure at radial strain-rates in the range 1.2 - 5.7 ×103s-1. The temporal history of fracture activation is captured using high speed photography and modelled using a combined statistics and energy based fragmentation theory. The model is shown to reproduce the crack dynamics and strain-rate dependence reasonably well.

  9. Pascual Jordan, Varying Gravity, and the Expanding Earth

    Science.gov (United States)

    Kragh, Helge

    2015-06-01

    In the 1950s, surprising links were proposed between cosmological theory and the geological and paleontological sciences. These links were mainly provided by Paul Dirac's hypothesis of 1937 that the gravitational constant G decreases with cosmic time. Pascual Jordan, famous for his pioneering contributions to quantum theory, took up Dirac's hypothesis; after the end of World War II, Jordan developed its geophysical consequences, concluding that the Earth is expanding. Much of Jordan's later scientific work focused on the expanding Earth and other aspects of the earth sciences relating to the varying- G hypothesis. This chapter in the history of science has received almost no attention from either scientists or historians. The article analyzes Jordan's cosmo-geological work in relation to the somewhat similar efforts of other "expansionists" in the period that led to the plate tectonic revolution in the earth sciences.

  10. Expanding Earth and Static Universe: Two Papers of 1935

    CERN Document Server

    Kragh, Helge

    2015-01-01

    The German-born astronomer Jacob K. E. Halm (1866-1944) wrote in 1935 two papers on quite different subjects, one an astrophysically based argument for the expanding Earth and the other a no less original attempt to explain the galactic redshifts on the basis of a static universe. Of course, Halm was wrong in both cases. The second of the papers is reproduced in toto and compared to other early attempts to avoid the expansion of the universe by means of "tired light" explanations of the redshifts. Although often referred to in the literature on the expanding Earth, the content of Halm's first paper is not well known. This article also provides a brief account of Halm's life and scientific career, which included important studies of the solar spectrum (the "limb effect") and the first version of the mass-luminosity relation for stars.

  11. Einstein's conversion from his static to an expanding universe

    Science.gov (United States)

    Nussbaumer, Harry

    2014-02-01

    In 1917 Einstein initiated modern cosmology by postulating, based on general relativity, a homogenous, static, spatially curved universe. To counteract gravitational contraction he introduced the cosmological constant. In 1922 Alexander Friedman showed that Albert Einstein's fundamental equations also allow dynamical worlds, and in 1927 Georges Lemaître, backed by observational evidence, concluded that our universe was expanding. Einstein impetuously rejected Friedman's as well as Lemaître's findings. However, in 1931 he retracted his former static model in favour of a dynamic solution. This investigation follows Einstein on his hesitating path from a static to the expanding universe. Contrary to an often advocated belief the primary motive for his switch was not observational evidence, but the realisation that his static model was unstable.

  12. Internally folded expanded metal electrode for battery construction

    Science.gov (United States)

    Korinek, Paul D. (Inventor); Morgan, Maurice C. (Inventor); Pierce, Doug C. (Inventor)

    1993-01-01

    A battery system is disclosed which includes folded grids of expanded metal inserted through non-conductive substrates and pasted with electrochemically active materials. In the most preferred embodiment, a frame is provided with a plastic insert, and slots are provided in the latter to receive the expanded metal grid. After suitable coinage of the grid and insertion through the plastic film, the grid is sealed and pasted on opposite sides with positive and negative active material. A battery is assembled using one or a plurality of the resulting electrode elements, with separators, to produce a high-power, lead-acid battery. The folded grid provides many of the design benefits of standard bipolar construction.

  13. A beam expander facility for studying x-ray optics

    DEFF Research Database (Denmark)

    Christensen, Finn Erland; Hornstrup, Allan; Frederiksen, P.; Nilsson, C.; Grundsøe, Peter; Ørup, P.; Jacobsen, E.; Schnopper, H. W.; Lewis, R.; Hall, C.

    1992-01-01

    The detailed study of the performance of full scale x-ray optics often requires the illumination of large areas. This paper describes a beam expander facility at the Daresbury Synchrotron Radiation Facility. It combines monochromatization and beam expansion in one dimension. The beam expansion is...... obtained from an extremely asymmetric reflection in a large single crystal of Si. An expansion of a factor of 50 was obtained in one dimension. The expanded beam of ~85 mm is limited only by the crystal size. The facility is installed in a 12-m-long hutch. A specific application, in which a high throughput...... x-ray telescope will be studied, is described in detail. Review of Scientific Instruments is copyrighted by The American Institute of Physics....

  14. The HBT-interferometry of expanding inhomogeneous sources

    International Nuclear Information System (INIS)

    The Bose-Einstein correlations of pions and kaons emitted from expanding inhomogeneous systems that eventually formed on ultra-relativistic A+A collisions are considered.The structure of the correlation function is obtained using the conception of the system's lengths of homogeneity. The analysis of the transversal momentum behavior of the long-, out- and side-interferometry radii is done for radiating sources with relativistic transversal and longitudinal flows moreover for the sources with large temperature gradients. The universal ratios between the momentum slopes of the different interferometry radii of 3 D expanding systems are found at the large transversal momenta. The simple analytical formulas for the all interferometry radii are obtained for typical classes of transversal flows. 8 refs., 3 figs

  15. Einstein's conversion from his static to an expanding universe

    CERN Document Server

    Nussbaumer, Harry

    2013-01-01

    In 1917 Einstein initiated modern cosmology by postulating, based on general relativity, a homogeneous, static, spatially curved universe. To counteract gravitational contraction he introduced the cosmological constant. In 1922 Alexander Friedman showed that Einstein's fundamental equation also allowed dynamical worlds, and in 1927 Geroges Lemaitre, backed by observational evidence, concluded that our universe was expanding. Einstein impetuously rejected Friedman's as well as Lemaitre's findings. However, in 1931 he retracted his former static model in favour of a dynamic solution. This investigation follows Einstein on his hesitating path from a static to the expanding universe. Contrary to an often repeated belief the primary motive for his switch was not observational evidence, but the realisation that his static model was unstable.

  16. Neutron Generation and Kinetic Energy of Expanding Laser Plasmas

    Institute of Scientific and Technical Information of China (English)

    HUANG Yong-Sheng; WANG Nai-Yan; DUAN Xiao-Jiao; LAN Xiao-Fei; TAN Zhi-Xin; TANG Xiu-Zhang; HE Ye-Xi

    2007-01-01

    We investigate the kinetic energy of expanding plasma of a solid target heated by a ultra-short and ultra-intense laser pulse and the efficiency of energy coupling between the ultra-intense laser pulse and the solid target, in order to increase the utilization ratio of laser energy and to raise the neutron generation farther. Some new ideas about improving the energy utilization by head-on collisions between the expanding plasmas are proposed. The significance is the raise of generation of shorter duration neutron, of the order of picoseconds, which allows for an increase of energy resolution in time-of-flight experiments and also for the investigation of the dynamics of nuclear processes with high temporal resolution.

  17. Expanding the taxonomy of the diagnostic criteria for temporomandibular disorders

    DEFF Research Database (Denmark)

    Peck, C C; Goulet, J-P; Lobbezoo, F;

    2014-01-01

    There is a need to expand the current temporomandibular disorders' (TMDs) classification to include less common but clinically important disorders. The immediate aim was to develop a consensus-based classification system and associated diagnostic criteria that have clinical and research utility...... for less common TMDs. The long-term aim was to establish a foundation, vis-à-vis this classification system, that will stimulate data collection, validity testing and further criteria refinement. A working group [members of the International RDC/TMD Consortium Network of the International Association...... criteria and the ability to operationalise and study the criteria. The disorders were derived from the literature when possible and based on expert opinion as necessary. The expanded TMDs taxonomy was presented for feedback at international meetings. Of 56 disorders considered, 37 were included...

  18. Interaction of a Pulsar Wind with the Expanding Supernova Remnant

    CERN Document Server

    Jun, B I

    1997-01-01

    Recent HST observations of the Crab Nebula show filamentary structures that appear to originate from the Rayleigh-Taylor (R-T) instability operating on the supernova ejecta accelerated by the pulsar-driven wind. In order to understand the origin and formation of the filaments in the Crab Nebula, we study the interaction of a pulsar wind with the uniformly expanding supernova remnant by means of numerical simulation. By performing two-dimensional numerical simulations, we find three independent instabilities in the interaction region between the pulsar wind and the expanding supernova remnant. The most important instability develops as the shock driven by the pulsar bubble becomes accelerated ($r \\propto t^{6/5}$). The instability produces pronounced filamentary structures that resemble the observed filaments in the Crab Nebula. Our numerical simulations can reproduce important observational features of the Crab Nebula. The high density heads in the R-T finger tips are produced because of the compressibility o...

  19. A two-mass expanding exact space-time solution

    CERN Document Server

    Uzan, Jean-Philippe; Larena, Julien

    2010-01-01

    In order to understand how locally static configurations around gravitationally bound bodies can be embedded in an expanding universe, we investigate the solutions of general relativity describing a space-time whose spatial sections have the topology of a 3-sphere with two identical masses at the poles. We show that Israel junction conditions imply that two spherically symmetric static regions around the masses cannot be glued together. If one is interested in an exterior solution, this prevents the geometry around the masses to be of the Schwarzschild type and leads to the introduction of a cosmological constant. The study of the extension of the Kottler space-time shows that there exists a non-static solution consisting of two static regions surrounding the masses that match a Kantowski-Sachs expanding region on the cosmological horizon. The comparison with a Swiss-Cheese construction is also discussed.

  20. A Small Power Recovery Expander for Heat Pump COP Improvement

    OpenAIRE

    Ferrara, G.; Ferrari, L.; D. Fiaschi; Galoppi, G.; Karellas, S.; Secchi, R; Tempesti, D.

    2015-01-01

    Heat pumps are becoming more and more applied for heating, due to their possibility of working as cooling systems in the summer period. However, up to now, recovery of expansion work in small system has not been considered as a viable solution, because of the limited amount of recoverable energy and of difficulties in designing and operating a two-phase flow expander. The idea here presented is to investigate the application of a radial piston machine, adapted from oleodynamic motor design...

  1. Expanding the Enterprise Exports by E-business

    OpenAIRE

    Hongxin Li; Weihe Duan

    2010-01-01

    With unexampled advantages, E-business has developed quickly, and enterprises should have to grasp thisopportunity. At present, the problems about expanding the enterprise exports by E-business mainly include thatthe innovation of international trade enterprise mode in the E-business environment is deficient, theinformationization level of enterprise should be further enhanced, the senior E-business talents are deficient, andthe support system of E-business should be further perfected. Theref...

  2. Systematic Shared Value in Finance: Expanding Porter's Approach

    OpenAIRE

    Marta Rocchi; Ignacio Ferrero

    2014-01-01

    The publication of Michael Porter and Mark Kramer's Creating Shared Value (Harvard Business Review, 2011) challenges both the academic literature on corporate social responsibility as well as business practice. Porter and Kramer argue that there is a better way of integrating social goals within business practice, without distracting a firm from its primary purpose of achieving profit. This paper aims to expand Porter and Kramer's approach and to apply the shared value model to the financial ...

  3. Rapid shifts in dispersal behavior on an expanding range edge

    OpenAIRE

    Lindström, Tom; Brown, Gregory P.; Sisson, Scott A.; Phillips, Benjamin L.; Shine, Richard

    2013-01-01

    Dispersal biology at an invasion front differs from that of populations within the range core, because novel evolutionary and ecological processes come into play in the nonequilibrium conditions at expanding range edges. In a world where species’ range limits are changing rapidly, we need to understand how individuals disperse at an invasion front. We analyzed an extensive dataset from radio-tracking invasive cane toads (Rhinella marina) over the first 8 y since they arrived at a site in trop...

  4. ELECROGASDYNAMIC GENERATOR-EXPANDER FOR NATURAL GAS LIQUEFIERS

    OpenAIRE

    Бумагин, Г. И.; Бородин, Д. В.; Зиновьева, А. В.; Роханский, А. Е.; Рогальский, Е. И.

    2015-01-01

    The paper deals with various ways of obtaining liquefied natural gas (LNG) in liquefiers of different cold producing elements such as an expansion valve, a vortex tube and a turboexpander. It provides a brief analysis of their efficiency, advantages and disadvantages. The electrogasdynamic generator-expander as a cold producing element in natural gas liquefiers is proposed. Utilizing energy of compressed pipe-line natural gas should be taken into account. The circuits of the new stage and the...

  5. Avoiding Intellectual Stagnation: The Starship as an Expander of Minds

    OpenAIRE

    Crawford, Ian A.

    2015-01-01

    Interstellar exploration will advance human knowledge and culture in multiple ways. Scientifically, it will advance our understanding of the interstellar medium, stellar astrophysics, planetary science and astrobiology. In addition, significant societal and cultural benefits will result from a programme of interstellar exploration and colonisation. Most important will be the cultural stimuli resulting from expanding the horizons of human experience, and increased opportunities for the spread ...

  6. Beyond the Numbers: Expanding the Boundaries of Neuropsychology†

    OpenAIRE

    Perry, William

    2009-01-01

    Beyond the Numbers: Expanding the Boundaries of Neuropsychology was Dr Perry's 2007 presidential address in the annual conference of the National Academy of Neuropsychology. In his address he discussed the achievements of the science of neuropsychology and highlighted some areas that exemplified the expansion of the boundaries of neuropsychology. These areas are: (i) the study of neuropsychological functioning in new or non-traditional populations, particularly seemingly healthy people and pe...

  7. AN INTEGRABLE HIERARCHY AND ITS EXPANDING LAX INTEGRABLE MODEL

    Institute of Scientific and Technical Information of China (English)

    张玉峰; 闫庆友; 许曰才

    2004-01-01

    In general, Liouville integrable hierarchies of evolution equations were obtained by choosing proper U in zero curvature frame Ut - Vx + [U, V] = 0 first. But in the present paper, a new Liouville integrable hierarchy possessing bi-Hamiltonian structure is obtained by choosing V with derivatives in x and spectral potentials. Then integrable coupling, i.e. expanding Lax integrable model of the hierarchy obtained is presented by constructing a subalgebra of loop algebra A2.

  8. Expanding Science Teacher Preparation: the Role of External Funding

    Science.gov (United States)

    Lindberg, John M.; Vokos, S.; Seeley, L.; Close, E.

    2006-12-01

    The Department of Physics and the School of Education at Seattle Pacific University are in the early stages of expanding the scope and reach of our science teacher preparation. We will describe how we are putting the puzzle together and our results to date. * Supported in part by NSF grant #ESI-0455796, NSF grant # DUE-0630460, NSF grant DUE-0310583, The Boeing Corporation, PhysTec and the SPU Science Initiative.

  9. The applications of the expanders on nuclear-powered ships

    International Nuclear Information System (INIS)

    The nuclear heating reactor has inherent safety with very simple structures, so it can be used as minitype nuclear-powered equipment. Due to the limits of dimensions and the requirements of mobility of the ship, it is need to simplify the total system. If the conventional steam-generators are replaced with expanders, the system is not only be simplified greatly, but the safety and reliability are improved extremely

  10. Low Rate of Infusional Toxicity following Expanded Cord Blood Transplantation

    OpenAIRE

    Bear, Adham S.; Hanley, Patrick J; Bosque, Doyle M; Cruz, Conrad R.; Kaur, Indresh; Liu, Hao; Kebriaei, Partow; Hosing, Chitra; Rezvani, Katayoun; Oran, Betul; de Lima, Marcos J.; Bollard, Catherine M.; Shpall, Elizabeth J.

    2014-01-01

    Umbilical cord blood (CB) is utilized with increasing frequency to restore hematopoiesis in bone marrow transplant patients lacking a suitable HLA-matched donor. CB transplantation is limited by low cell doses and delays in neutrophil and platelet engraftment. CB progenitors expanded ex vivo prior to transplantation provide more rapid hematopoietic and immune reconstitution, as well as less engraftment failure compared to unmanipulated CB. However, the safety of infusing double and ex vivo ex...

  11. The production of string loops in an expanding universe

    International Nuclear Information System (INIS)

    The production of closed loops of string in an expanding universe, and how these might later seed the process of galaxy formation is discussed. It is shown how the motion of string is damped on scales larger than the horizon, and is free beneath the horizon. In particular when two waves meet beneath the horizon it is shown how non-self-intersecting loops are produced. It is speculated that each loop leads to the formation of a single galaxy. (orig.)

  12. Aspergilloma in the frontal sinus expanding into the orbit.

    OpenAIRE

    Swoboda, H.; Ullrich, R

    1992-01-01

    A case of primary frontal sinus aspergilloma in a 79 year old non-immunocompromised woman, who presented with a right sided pyocele expanding into the orbit, is presented. The low susceptibility of the frontal sinus is probably related to the brachycephalic shape of the human skull which locates this sinus far anterosuperiorly to the nasal cavity. In human frontal sinus aspergillosis nasal symptoms are absent; the clinical manifestation of this rare disease is initiated by complications, espe...

  13. Introduction: Expanding the boundaries of psychological resource theories

    OpenAIRE

    Gorgievski-Duijvesteijn, Marjan; Halbesleben, Jonathon; Bakker, Arnold

    2011-01-01

    textabstractAbstract This article introduces JOOP’s special section on expanding the boundaries of resource theories in Occupational and Organizational Psychology. After an introduction of the most relevant resource theories and their current application in Occupational and Organizational Psychology – Key resource theories, Conservation of Resources Theory, Resource Theory of Social exchange, and Selective Optimization with Compensation Theory – the opportunities and challenges for future res...

  14. Environmental CPT violation in an expanding Universe in string theory

    International Nuclear Information System (INIS)

    We consider a model of an expanding Universe in string theory that yields ‘environmental’ CPT violation for fermions, in the sense of different dispersion relations for fermions and antifermions. These are induced by a cosmological background with constant torsion provided by the Kalb–Ramond antisymmetric tensor field (axion) of the string gravitational multiplet. This effect induces different densities of neutrinos and antineutrinos while in chemical equilibrium, offering new scenarios for leptogenesis and baryogenesis even in the absence of CP violation

  15. Expanding the Obesity Research Paradigm to Reach African American Communities

    Directory of Open Access Journals (Sweden)

    Shiriki K. Kumanyika, PhD, MPH

    2007-10-01

    Full Text Available Obesity is more prevalent among African Americans and other racial and ethnic minority populations than among whites. The behaviors that determine weight status are embedded in the core social and cultural processes and environments of day-to-day life in these populations. Therefore, identifying effective, sustainable solutions to obesity requires an ecological model that is inclusive of relevant contextual variables. Race and ethnicity are potent stratification variables in U.S. society and strongly influence life contexts, including many aspects that relate to eating and physical activity behaviors. This article describes a synthesis initiated by the African American Collaborative Obesity Research Network (AACORN to build and broaden the obesity research paradigm. The focus is on African Americans, but the expanded paradigm has broader implications and may apply to other populations of color. The synthesis involves both community and researcher perspectives, drawing on and integrating insights from an expanded set of knowledge domains to promote a deeper understanding of relevant contexts. To augment the traditional, biomedical focus on energy balance, the expanded paradigm includes insights from family sociology, literature, philosophy, transcultural psychology, marketing, economics, and studies of the built environment. We also emphasize the need for more attention to tensions that may affect African American or other researchers who identify or are identified as members of the communities they study. This expanded paradigm, for which development is ongoing, poses new challenges for researchers who focus on obesity and obesity-related health disparities but also promises discovery of new directions that can lead to new solutions.

  16. The price effect of expanding fish auction markets

    OpenAIRE

    Patrice Guillotreau; Ramón Jiménez-Toribio

    2011-01-01

    Fish markets can be expanded by two means, first by attracting newcomers in a local trading room and secondly by allowing remote bidders to participate. In both cases, electronic systems have played a key role in French primary fish markets. The computerisation of trading rooms started in the mid-1980s while connection through intranet or internet systems first started in the mid-1990s and then has spread more actively in France since 2007. However, the socioeconomic impact (on prices for exa...

  17. On the creation of particles in some expanding closed universe

    International Nuclear Information System (INIS)

    The purpose of this letter is to study the pair creation of particles in an expanding universe by analyzing the dynamical behavior of the Feynman propagator. To deal with the pair creation of particles in the universe under consideration, concrete information about the Feynman propagator in the asymptotic region must be obtained. The Feynman propagator is compared with the corresponding one in case of Chitre-Hartle's model-universe. (Kato, T.)

  18. Debye's length in expanding quark-gluon plasma

    International Nuclear Information System (INIS)

    The screening properties of an abelian quark-gluon plasma and boost invariantly expanding in a given direction, are discussed. The expansion results in anisotropic screening. At early stages of the process, the Debye length along the direction of the expansion is reduced by a factor of about 2, relative to static calculations. This may have important consequences for the J/ψ production rate. 12 refs., 2 figs., 1 tab. (author)

  19. Fluorescence measurements of expanding strongly-coupled neutral plasmas

    CERN Document Server

    Cummings, E A; Durfee, D S; Bergeson, S D

    2005-01-01

    We report new detailed density profile measurements in expanding strongly-coupled neutral plasmas. Using laser-induced fluorescence techniques, we determine plasma densities in the range of 10^5 to 10^9/cm^3 with a time resolution limit as small as 7 ns. Strong-coupling in the plasma ions is inferred directly from the fluorescence signals. Evidence for strong-coupling at late times is presented, confirming a recent theoretical result.

  20. Cellular Concrete Bricks with Recycled Expanded Polystyrene Aggregate

    OpenAIRE

    Juan Bosco Hernández-Zaragoza; Teresa López-Lara; Jaime Horta-Rangel; Carlos López-Cajún; Eduardo Rojas-González; F. J. García-Rodríguez; Jorge Adue

    2013-01-01

    Cellular concrete bricks were obtained by using a lightweight mortar with recycled expanded polystyrene aggregate instead of sandy materials. After determining the block properties (absorption, compressive strength, and tensile stresses), it was found that this brick meets the requirements of the masonry standards used in Mexico. The obtained material is lighter than the commercial ones, which facilitates their rapid elaboration, quality control, and transportation. It is less permeable, whic...

  1. Collective modes and instabilities in anisotropically expanding ultarelativistic plasmas

    OpenAIRE

    Rebhan, Anton; Steineder, Dominik

    2009-01-01

    The time evolution of collective modes in an expanding ultarelativistic and (effectively) Abelian plasma is studied in the hard-loop approximation semi-analytically by means of integro-differential equations. A previous treatment is generalized to arbitrary orientation of wave vectors with respect to the direction of anisotropy and thus to a fully 3+1 dimensional situation. Moreover, initial fluctuations are allowed in both gauge fields and currents, which is necessary in the case of (stable)...

  2. A Model of Foam Density Prediction for Expanded Perlite Composites

    OpenAIRE

    Arifuzzaman Md; Kim Ho Sung

    2015-01-01

    Multiple sets of variables associated with expanded perlite particle consolidation in foam manufacturing were analyzed to develop a model for predicting perlite foam density. The consolidation of perlite particles based on the flotation method and compaction involves numerous variables leading to the final perlite foam density. The variables include binder content, compaction ratio, perlite particle size, various perlite particle densities and porosities, and various volumes of perlite at dif...

  3. Stability of stagnation via an expanding accretion shock wave

    CERN Document Server

    Velikovich, A L; Taylor, B D; Giuliani, J L; Zalesak, S T; Iwamoto, Y

    2016-01-01

    Stagnation of a cold plasma streaming to the center or axis of symmetry via an expanding accretion shock wave is ubiquitous in inertial confinement fusion (ICF) and high-energy-density plasma physics, the examples ranging from plasma flows in x-ray-generating Z pinches [Y. Maron et al., Phys. Rev. Lett. 111, 035001 (2013)] to the experiments in support of the recently suggested concept of impact ignition in ICF [H. Azechi et al., Phys. Rev. Lett. 102, 235002 (2009); M. Murakami et al., Nucl. Fusion 54, 054007 (2014)]. Some experimental evidence indicates that stagnation via an expanding shock wave is stable, but its stability has never been studied theoretically. We present such analysis for the stagnation that does not involve a rarefaction wave behind the expanding shock front and is described by the classic ideal-gas Noh solution in spherical and cylindrical geometry. In either case the stagnated flow has been demonstrated to be stable, initial perturbations exhibiting a power-law, oscillatory or monotonic...

  4. Stability of stagnation via an expanding accretion shock wave

    Science.gov (United States)

    Velikovich, A. L.; Murakami, M.; Taylor, B. D.; Giuliani, J. L.; Zalesak, S. T.; Iwamoto, Y.

    2016-05-01

    Stagnation of a cold plasma streaming to the center or axis of symmetry via an expanding accretion shock wave is ubiquitous in inertial confinement fusion (ICF) and high-energy-density plasma physics, the examples ranging from plasma flows in x-ray-generating Z pinches [Maron et al., Phys. Rev. Lett. 111, 035001 (2013)] to the experiments in support of the recently suggested concept of impact ignition in ICF [Azechi et al., Phys. Rev. Lett. 102, 235002 (2009); Murakami et al., Nucl. Fusion 54, 054007 (2014)]. Some experimental evidence indicates that stagnation via an expanding shock wave is stable, but its stability has never been studied theoretically. We present such analysis for the stagnation that does not involve a rarefaction wave behind the expanding shock front and is described by the classic ideal-gas Noh solution in spherical and cylindrical geometry. In either case, the stagnated flow has been demonstrated to be stable, initial perturbations exhibiting a power-law, oscillatory or monotonic, decay with time for all the eigenmodes. This conclusion has been supported by our simulations done both on a Cartesian grid and on a curvilinear grid in spherical coordinates. Dispersion equation determining the eigenvalues of the problem and explicit formulas for the eigenfunction profiles corresponding to these eigenvalues are presented, making it possible to use the theory for hydrocode verification in two and three dimensions.

  5. On Dark Energy and Matter of the Expanding Universe

    Directory of Open Access Journals (Sweden)

    Lehnert B.

    2009-04-01

    Full Text Available At present the expanding universe is observed to be dominated by the not fully under- stood concepts of dark energy and matter, in a conceived almost flat Euclidian geometry. As one of the possible efforts to understand the global behaviour of the expanding uni- verse, the present paper attempts to explain these concepts in terms of the pressure force and gravity of a spherical photon gas cloud of zero point energy, in a flat geometry. A difficult point of the conventional theory concerns the frequency distribution of the zero point energy oscillations which leads to the unacceptable result of an infinite total en- ergy per unit volume. A modification of this distribution is therefore proposed which results in finite energy density. A corresponding equilibrium state is investigated, as well as small dynamic deviations from it, to form a basis for a model of the expanding universe. Provided that the crucial points of the present approach hold true, the model satisfies the requirements of cosmic linear dimensions, results in an estimated accelera- tion of the expansion being of the order of the observed one, presents a possible solution of the coincidence problem of dark energy and matter, and provides one of the possible explanations of the observed excess of high-energy electrons and positrons in recent balloon and satellite experiments.

  6. INSTRUMENTED MICROSCRATCH TESTS USAGE FOR STUDY OF EXPANDED AUSTENITE PROPERTIES

    Directory of Open Access Journals (Sweden)

    Fernando Luis Sato

    2015-06-01

    Full Text Available Corrosion resistance and poor mechanical properties are both characteristics of AISI 316 austenitic stainless steel. Nitrogen supersaturated expanded austenite, or S-phase, promotes surface hardening of the alloy without the formation of undesirable that can reduce passivation properties. Mechanical characterization of this layer using instrumented microscratch tests gives an important set of empirical data useful for comprehension and modeling of tribological phenomena occurring in mechanical system. This work presents results from a series of instrumented microscratch tests performed on Low Temperature Plasma Nitrided (LTPN AISI 316 stainless steel samples with an expanded austenite layer. The specimens were produced by 20 h active screen plasma nitriding treatment, done in direct current reactor at 400°C in an atmosphere containing three parts of nitrogen for one part of hydrogen (3N2 :1H2 . The reduced friction coefficient (< 0,1 between the indenter and the expanded austenite layer observed in the initial stage of scratch test and the absence of adhesive failure along the test are also discussed.

  7. Long-term consequences of observing an expanding cosmological civilization

    CERN Document Server

    Olson, S Jay

    2016-01-01

    Suppose that advanced civilizations, separated by a cosmological distance and time, wish to maximize their access to cosmic resources by rapidly expanding into the universe. What sort of boundary forms between their expanding domains, and how does the presence of one limit the ambitions of another? We describe a general case for any expansion speed, separation distance, and time. We then specialize to the main question of interest. How are the future prospects for a young and ambitious civilization altered if they can observe the presence of another at a cosmological distance? We treat cases involving the observation of one or two expanding domains. In the single-observation case, we find that almost any plausible detection will be limiting to some extent. Also, practical technological limits to expansion speed (well below the speed of light) play an interesting role. If a domain is visible at the time one embarks on expansion, there exists an optimum value for the "practical speed limit," and if the speed li...

  8. Atmospheric gradients and the stability of expanding jets

    International Nuclear Information System (INIS)

    Numerical simulations of adiabatically expanding slab jets in initial static pressure balance with an external atmosphere have been performed and compared to predictions made by a linear analysis of the stability of expanding jets. It is found that jets are stabilized by jet expansion as predicted by the linear analysis. It is also found that an expanding jet can be destabilized by a positive temperature gradient or temperature jump in the surrounding medium which lowers the Mach number defined by the external sound speed. A temperature gradient or jump is more destabilizing than would be predicted by a linear stability analysis. The enhanced instability compared to an isothermal atmosphere with identical pressure gradient is a result of the reduced external Mach number and a result of a higher jet density relative to the density in the external medium and higher ram speed. Other differences between predictions made by the linear theory and the simulations can be understood qualitatively as a result of a change in wave speed as the wave amplitude increases. 12 refs

  9. Prospects for expanded utilization of biogas in Germany

    International Nuclear Information System (INIS)

    The prospects for expanded utilization of biogas systems in German was analysed, by identifying the operational and policy factors affecting the complete chain of processes from implementation process for biogas plants, through to biogas production and utilization. It was found that the Renewable Energies Act (EEG) and energy tax reliefs provide bases for the support of expanded utilization. Upgrading of biogas to natural gas quality for utilization in the transportation sector was arguably the most promising technology that could support rapid utilization expansion. Sustainable deployment of biogas systems in light of the unstable feedstock prices and availability, and the need for subsidy-free operation in the long term requires; enhancement of feedstock flexibility and quality characteristics to maximise gas yield, and optimisation of the anaerobic digestion process management. Assessment of energy balance and potential environmental impacts of the integrated process chain provides a holistic assessment of sustainability. The results also support the development and foster of policies and framework for development of biogas as environmentally friendly energy resource, among a mix of renewable energy sources, hence, compete favourably with fossil fuels to enhance the prospects for expanded utilization. (author)

  10. Strain rate dependency and fragmentation pattern of expanding warheads

    Institute of Scientific and Technical Information of China (English)

    John F MOXNES; Anne K PRYTZ; yvind FRYLAND; Stian SKRIUDALEN; Steinar BRVE; Gard DEGRDSTUEN

    2015-01-01

    For the characterization of the behaviors of a metal material in events like expanding warheads, it is necessary to know its strength and ductility at high strain rates, around 104e105/s. The flyer plate impact testing produces the uniform stress and strain rates but the testing is expensive. The Taylor test is relatively inexpensive but produces non-uniform stress and strain fields, and the results are not so easily inferred for material modeling. In the split-Hopkinson bar (SHB), which may be used in compression, tension and torsion testing, the strain rates never exceeds 103/s. In the present work, we use the expanding ring test where the strain rate is 104e105/s. A streak camera is used to examine the expanding ring velocity, and a water tank is used to collect the fragments. The experimental results are compared with the numerical simulations using the hydrocodes AUTODYN, IMPETUS Afea and a regularized smooth particle (RSPH) software. The number of fragments increases with the increase in the expansion velocity of the rings. The number of fragments is similar to the experimental results. The RSPH software shows much the same results as the AUTODYN where the Lagrangian solver is used for the ring. The IMPETUS Afea solver shows a somewhat different fragmentation characteristic due to the node splitting algorithm that induces pronounced tensile splitting.

  11. An expanded prescribing role for pharmacists – an Australian perspective

    Directory of Open Access Journals (Sweden)

    Kreshnik Hoti

    2011-04-01

    Full Text Available Expanded pharmacist prescribing is a new professionalpractice area for pharmacists. Currently, Australianpharmacists’ prescribing role is limited to over-the-countermedications. This review aims to identify Australian studiesinvolving the area of expanded pharmacist prescribing.Australian studies exploring the issues of pharmacistprescribing were identified and considered in the context ofits implementation internationally. Australian studies havemainly focused on the attitudes of community and hospitalpharmacists towards such an expansion. Studies evaluatingthe views of Australian consumers and pharmacy clients werealso considered. The available Australian literature indicatedsupport from pharmacists and pharmacy clients for anexpanded pharmacist prescribing role, with preference fordoctors retaining a primary role in diagnosis. Australianpharmacists and pharmacy client’s views were also inagreement in terms of other key issues surrounding expandedpharmacist prescribing. These included the nature of anexpanded prescribing model, the need for additional trainingfor pharmacists and the potential for pharmacy clients gainingimproved medication access, which could be achieved withinan expanded role that pharmacists could provide. Currentevidence from studies conducted in Australia providesvaluable insight to relevant policymakers on the issue ofpharmacist prescribing in order to move the agenda ofpharmacist prescribing forwards.

  12. Use of functional gene arrays for elucidating in situ biodegradation

    Directory of Open Access Journals (Sweden)

    JoyD.Van Nostrand

    2012-09-01

    Full Text Available Microarrays have revolutionized the study of microbiology by providing a high-throughput method for examining thousands of genes with a single test and overcome the limitations of many culture-independent approaches. Functional gene arrays (FGA probe a wide range of genes involved in a variety of functions of interest to microbial ecology (e.g., carbon degradation, N-fixation, metal resistance from many different microorganisms, cultured and uncultured. The most comprehensive FGA to date is the GeoChip array, which targets tens of thousands of genes involved in the geochemical cycling of carbon, nitrogen, phosphorus, and sulphur, metal resistance and reduction, energy processing, antibiotic resistance and contaminant degradation as well as phylogenetic information (gyrB. Since the development of GeoChips, many studies have been performed using this FGA and have shown it to be a powerful tool for rapid, sensitive and specific examination of microbial communities in a high-throughput manner. As such, the GeoChip is well-suited for linking geochemical processes with microbial community function and structure. This technology has been used successfully to examine microbial communities before, during and after in situ bioremediation at a variety of contaminated sites. These studies have expanded our understanding of biodegradation and bioremediation processes and the associated microorganisms and environmental conditions responsible. This review provides an overview of FGA development with a focus on the GeoChip and highlights specific GeoChip studies involving in situ bioremediation.

  13. The expanding footprint of CRISPR/Cas9 in the plant sciences.

    Science.gov (United States)

    Schaeffer, Scott M; Nakata, Paul A

    2016-07-01

    CRISPR/Cas9 has evolved and transformed the field of biology at an unprecedented pace. From the initial purpose of introducing a site specific mutation within a genome of choice, this technology has morphed into enabling a wide array of molecular applications, including site-specific transgene insertion and multiplexing for the simultaneous induction of multiple cleavage events. Efficiency, specificity, and flexibility are key attributes that have solidified CRISPR/Cas9 as the genome-editing tool of choice by scientists from all areas of biology. Within the field of plant biology, several CRISPR/Cas9 technologies, developed in other biological systems, have been successfully implemented to probe plant gene function and to modify specific crop traits. It is anticipated that this trend will persist and lead to the development of new applications and modifications of the CRISPR technology, adding to an ever-expanding collection of genome-editing tools. We envision that these tools will bestow plant researchers with new utilities to alter genome complexity, engineer site-specific integration events, control gene expression, generate transgene-free edited crops, and prevent or cure plant viral disease. The successful implementation of such utilities will represent a new frontier in plant biotechnology. PMID:27137209

  14. Dependently typed array programs don't go wrong

    NARCIS (Netherlands)

    K. Trojahner; C. Grelck

    2008-01-01

    The array programming paradigm adopts multidimensional arrays as the fundamental data structures of computation. Array operations process entire arrays instead of just single elements. This makes array programs highly expressive and introduces data parallelism in a natural way. Array programming imp

  15. Dependently typed array programs don’t go wrong

    NARCIS (Netherlands)

    K. Trojahner; C. Grelck

    2007-01-01

    The array programming paradigm adopts multidimensional arrays as the fundamental data structures of computation. Array operations process entire arrays instead of just single elements. This makes array programs highly expressive and introduces data parallelism in a natural way. Array programming imp

  16. Dependently typed array programs don’t go wrong

    NARCIS (Netherlands)

    K. Trojahner; C. Grelck

    2009-01-01

    The array programming paradigm adopts multidimensional arrays as the fundamental data structures of computation. Array operations process entire arrays instead of just single elements. This makes array programs highly expressive and introduces data parallelism in a natural way. Array programming imp

  17. Efficient Analysis of Systems Biology Markup Language Models of Cellular Populations Using Arrays.

    Science.gov (United States)

    Watanabe, Leandro; Myers, Chris J

    2016-08-19

    The Systems Biology Markup Language (SBML) has been widely used for modeling biological systems. Although SBML has been successful in representing a wide variety of biochemical models, the core standard lacks the structure for representing large complex regular systems in a standard way, such as whole-cell and cellular population models. These models require a large number of variables to represent certain aspects of these types of models, such as the chromosome in the whole-cell model and the many identical cell models in a cellular population. While SBML core is not designed to handle these types of models efficiently, the proposed SBML arrays package can represent such regular structures more easily. However, in order to take full advantage of the package, analysis needs to be aware of the arrays structure. When expanding the array constructs within a model, some of the advantages of using arrays are lost. This paper describes a more efficient way to simulate arrayed models. To illustrate the proposed method, this paper uses a population of repressilator and genetic toggle switch circuits as examples. Results show that there are memory benefits using this approach with a modest cost in runtime. PMID:26912276

  18. Environmental Assessment Expanded Ponnequin Wind Energy Project Weld County, Colorado

    Energy Technology Data Exchange (ETDEWEB)

    N/A

    1999-03-02

    The U.S.Department of Energy (DOE) has considered a proposal from the State of Colorado, Office of Energy Conservation (OEC), for funding construction of the Expanded Ponnequin Wind Project in Weld County, Colorado. OEC plans to enter into a contracting arrangement with Public Service Company of Colorado (PSCO) for the completion of these activities. PSCo, along with its subcontractors and business partners, are jointly developing the Expanded Ponnequin Wind Project. DOE completed an environmental assessment of the original proposed project in August 1997. Since then, the geographic scope and the design of the project changed, necessitating additional review of the project under the National Environmental Policy Act. The project now calls for the possible construction of up to 48 wind turbines on State and private lands. PSCo and its partners have initiated construction of the project on private land in Weld County, Colorado. A substation, access road and some wind turbines have been installed. However, to date, DOE has not provided any funding for these activities. DOE, through its Commercialization Ventures Program, has solicited applications for financial assistance from state energy offices, in a teaming arrangement with private-sector organizations, for projects that will accelerate the commercialization of emerging renewable energy technologies. The Commercialization Ventures Program was established by the Renewable Energy and Energy Efficiency Technology Competitiveness Act of 1989 (P.L. 101-218) as amended by the Energy Policy Act of 1992 (P.L. 102-486). The Program seeks to assist entry into the marketplace of newly emerging renewable energy technologies, or of innovative applications of existing technologies. In short, an emerging renewable energy technology is one which has already proven viable but which has had little or no operational experience. The Program is managed by the Department of Energy, Office of Energy Efficiency and Renewable Energy. The

  19. Taylor relaxation and lambda decay of unbounded, freely expanding spheromaks

    OpenAIRE

    Yee, J; Bellan, P. M.

    2000-01-01

    A magnetized coaxial gun is discharged into a much larger vacuum chamber and the subsequent evolution of the plasma is observed using high speed cameras and a magnetic probe array. Photographic results indicate four distinct regimes of operation, labeled I–IV, each possessing qualitatively different dynamics, with the parameter lambdagun = µ0Igun/Phibias determining the operative regime. Plasmas produced in Regime II are identified as detached spheromak configurations. Images depict a donut-l...

  20. Multicolor photonic crystal laser array

    Energy Technology Data Exchange (ETDEWEB)

    Wright, Jeremy B; Brener, Igal; Subramania, Ganapathi S; Wang, George T; Li, Qiming

    2015-04-28

    A multicolor photonic crystal laser array comprises pixels of monolithically grown gain sections each with a different emission center wavelength. As an example, two-dimensional surface-emitting photonic crystal lasers comprising broad gain-bandwidth III-nitride multiple quantum well axial heterostructures were fabricated using a novel top-down nanowire fabrication method. Single-mode lasing was obtained in the blue-violet spectral region with 60 nm of tuning (or 16% of the nominal center wavelength) that was determined purely by the photonic crystal geometry. This approach can be extended to cover the entire visible spectrum.